Prostaglandins E1 and E2 antagonize norepinephrine effects on cerebellar purkinje cells: microelectrophoretic study.
In microelectrophoretic experiments, prostaglandins E(1) and E(2) antagonize the reduction in discharge rate of cerebellar Purkinje cells produced by norepinephrine. Slowing of discharge evoked by 3',5'-adenosine monophosphate or gamma aminobutyric acid is not antagonized. These data provide the first indication that endogenous prostaglandins may physiologically function to modulate central noradrenergic junctions.
D000200:Action Potentials; D000227:Adenine Nucleotides / Q000494:pharmacology; D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D002531:Cerebellum / Q000187:drug effects*; D004336:Drug Antagonism; D004586:Electrophoresis; D008846:Micromanipulation; D009638:Norepinephrine / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*; D011689:Purkinje Cells / Q000187:drug effects*; D051381:Rats
D000227:Adenine Nucleotides; D000613:Aminobutyrates; D011453:Prostaglandins; D009638:Norepinephrine