An accuate method for measurement of aldosterone production.
A method is described for isolation of the acid-hydrolysable metabolite of aldosterone in sufficient purity to measure accurately the daily production rate. Values obtained with six hospital patients were 84-131mug./day on a daily intake of 100m-equiv. of Na(+) and 227-464mug./day on a daily intake of 10m-equiv. of Na(+). Corresponding values for aldosterone excretion were also recorded, but these are a poor index of production rate since they represent from 1.6 to 9.8% of the total daily output of aldosterone.
D000450:Aldosterone / Q000096:biosynthesis* / Q000378:metabolism / Q000652:urine; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D004032:Diet; D006801:Humans; D008722:Methods; D012964:Sodium; D014316:Tritium
D014316:Tritium; D000450:Aldosterone; D012964:Sodium