Biological studies with alpha-dehydrobiotin.
A growing culture of Streptomyces lydicus converted biotin-(14)C to alpha-dehydrobiotin-(14)C. The conversion was demonstrated by isolating crystalline alpha-dehydrobiotin-(14)C from fermentation liquors supplemented with biotin-(14)C. The addition of pimelic acid-(14)C to the growing culture did not produce any radioactive alpha-dehydrobiotin. alpha-Dehydrobiotin did not substitute for biotin in Lactobacillus plantarum or in Saccharomyces cerevisiae. Antimicrobial activity of alpha-dehydrobiotin was abolished by avidin. alpha-Dehydrobiotin appears to be different from several biotin vitamers described in the literature. It is concluded that alpha-dehydrobiotin is a product of biotin catabolism in S. lydicus.
D001710:Biotin / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002621:Chemistry; D002854:Chromatography, Paper; D003460:Crystallization; D003470:Culture Media; D005285:Fermentation; D007778:Lactobacillus / Q000254:growth & development / Q000378:metabolism; D010047:Ovalbumin / Q000494:pharmacology; D010867:Pimelic Acids / Q000378:metabolism; D012440:Saccharomyces / Q000254:growth & development / Q000378:metabolism; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism
D002247:Carbon Isotopes; D003470:Culture Media; D010867:Pimelic Acids; D001710:Biotin; D010047:Ovalbumin