Insulin sensitivity and vascular disease in maturity-onset diabetics.
In 27 maturity-onset diabetics of more than 10 years' duration there was a significant tendency for both atherosclerosis and microangiopathy to be associated with a reduction in the acute hypoglycaemic effect of intravenous beef insulin. This finding is identical to that in a group of 51 insulin-dependent diabetics previously reported.It is suggested that insulin insensitivity probably precedes the appearance of vascular disease in diabetes and may be implicated in its production.
D000368:Aged; D001161:Arteriosclerosis / Q000209:etiology; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000209:etiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin