Kinetics and mechanism of bacterial disinfection by chlorine dioxide.
Survival data are presented for a fecal strain of Escherichia coli exposed to three concentrations of chlorine dioxide at four temperatures. Chick's first-order reaction equation is generalized to a pseudo nth-order model. Nonlinear least squares curve-fitting of the survival data to the nth order model was performed on an analogue computer. The data were observed to follow fractional order kinetics with respect to survival concentration, with an apparent activation energy of 12,000 cal/mole. Initial experiments support the thesis that the mechanism of chlorine dioxide kill occurs via disruption of protein synthesis.
D001426:Bacterial Proteins / Q000096:biosynthesis; D002621:Chemistry / Q000295:instrumentation; D002713:Chlorine / Q000494:pharmacology*; D004202:Disinfectants / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism*; D007700:Kinetics; D010087:Oxides / Q000494:pharmacology*; D013696:Temperature
D001426:Bacterial Proteins; D004202:Disinfectants; D010087:Oxides; D002713:Chlorine