Studies on flavonoid metabolism. Metabolism of (+)-[14C] catechin in the rat and guinea pig.
1. The fate of (+)-[U-(14)C]catechin and (+)-[ring A-(14)C]catechin has been studied in the guinea pig and rat. 2. (+)-[U-(14)C]Catechin was shown to give rise to labelled phenolic acids, labelled phenyl-gamma-valerolactones and (14)CO(2). 3. (+)-[ring A-(14)C]-Catechin did not give rise to labelled phenolic acids, but labelled phenyl-gamma-valerolactones were detected together with a higher proportion of (14)CO(2). 4. Administered [(14)C]delta-(3-hydroxyphenyl)-gamma-valerolactone gave rise to labelled m-hydroxyphenylpropionic acid in the rat whereas administered [(14)C]m-hydroxyphenylpropionic acid gave rise to a compound yielding labelled m-hydroxybenzoic acid on hydrolysis. 5. The distribution of radioactivity in the urine and faeces of (+)-[(14)C]catechin-fed animals is described; a high proportion of residual radioactivity was found in urine that had been exhaustively extracted with diethyl ether.
D000818:Animals; D001565:Benzoates / Q000652:urine; D002245:Carbon Dioxide / Q000096:biosynthesis; D002247:Carbon Isotopes; D002392:Catechin / Q000378:metabolism*; D002854:Chromatography, Paper; D005243:Feces / Q000032:analysis; D006168:Guinea Pigs; D007783:Lactones / Q000652:urine; D010636:Phenols / Q000652:urine; D051381:Rats
D001565:Benzoates; D002247:Carbon Isotopes; D007783:Lactones; D010636:Phenols; D002245:Carbon Dioxide; D002392:Catechin