Avoidance learning: long-lasting deficits after temporal lobe seizure.
Microinjections of carbachol (carbamylcholine chloride) into the amygdaloid complex of rats produced behavioral and electrophysiological seizures which subsided within 24 hours. A persisting functional change caused a deficit in avoidance learning 1 to 3 weeks after the seizure. A cholinergic system is implicated by the fact that cholinergic blockade (scopolamine) of the amygdala during training reversed the effects of the seizures induced by carbachol.
D000679:Amygdala / Q000187:drug effects; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology*; D003213:Conditioning, Psychological; D007267:Injections; D008846:Micromanipulation; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013702:Temporal Lobe / Q000187:drug effects*; D013995:Time
D002217:Carbachol; D012601:Scopolamine