Effects of chronic administration of (+)-amphetamine on maze performance of the rat.
1. The influence of (+)-amphetamine, given 1 min after each training session, on the performance of 124 rats in a Lashley III maze was measured every 48 hr.2. The first three injections of the drug significantly improved the learning ability of naive rats.3. With prolonged treatment, (+)-amphetamine strongly impaired the maze performance of these rats.4. The chronic administration of (+)-amphetamine to previously trained rats produced the same adverse effect.5. Amylobarbitone sodium given to previously trained rats 30 min before the training sessions completely blocked the adverse effect of (+)-amphetamine.6. (+)-Amphetamine did not produce impairment of performance when given chronically 30 min before training sessions, to previously trained rats.
D000654:Amobarbital / Q000494:pharmacology; D000818:Animals; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D000654:Amobarbital; D003913:Dextroamphetamine