Effect of metoclopramide on transport in the small intestine of the dog.
A method is described for the simultaneous measurement of flow rate, mean transit time, and volume of the intestine during the transport of fluid through a segment of the small intestine of the dog. Using this method, the effect of metoclopramide on motility of the small bowel was assessed. The drug resulted in a decrease in transit time and volume in the test segment of bowel while the flow rate remained constant. This finding suggests that metoclopramide-stimulated contraction of intestinal smooth muscle.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects*; D004396:Coloring Agents; D004285:Dogs; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D007583:Jejunum / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D010477:Perfusion; D011342:Procainamide / Q000494:pharmacology*
D004396:Coloring Agents; D005765:Gastrointestinal Agents; D011342:Procainamide