Active and passive immunization in the adult rabbit ileal loop model as an assay for production of antitoxin immunity by cholera vaccines.
Three field trial cholera vaccines did not induce antitoxic immunity. A choleragenic toxin induced high-serum neutralizing antibody, but protection to loop challenge with toxin was minimal.
D000818:Animals; D000917:Antibody Formation; D000992:Antitoxins / Q000032:analysis*; D002771:Cholera / Q000276:immunology*; D022121:Cholera Vaccines; D007082:Ileum; D007110:Immunity, Active; D007112:Immunity, Maternally-Acquired; D007275:Injections, Intravenous; D008954:Models, Biological; D009500:Neutralization Tests; D011817:Rabbits; D014611:Vaccination
D000992:Antitoxins; D022121:Cholera Vaccines