Vascular smooth muscle reactivity in normotensive and hypertensive rats.
Aortic strips from spontaneously hypertensive rats were less responsive than normal animals to the contractile effects of norepinephrine, serotonin, and potassium chloride but more reactive to the relaxant effects of the stimulant of beta receptors, isoproterenol. Thus, hypertension is not the result of an absence of beta receptor or a hypersensitivity of the vascular smooth muscle.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D001794:Blood Pressure; D006973:Hypertension / Q000503:physiopathology*; D007545:Isoproterenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D011189:Potassium Chloride; D007545:Isoproterenol; D009638:Norepinephrine