Studies on the metabolism of steroids in the foetus. Biosynthesis of 6-alpha-hydroxytestosterone in the human foetal liver.
After incubation of testosterone with 105000g microsomes of human foetal liver, 6alpha-hydroxytestosterone was isolated and identified by t.l.c. and g.l.c.-mass spectrometry. This is the first example of 6alpha-hydroxylation of C(19) steroids in the human liver, and the finding is discussed in relation to earlier reports of 6-oxygenated C(19) and C(18) steroids in pregnant women.
D015065:17-Hydroxycorticosteroids / Q000032:analysis / Q000096:biosynthesis*; D000731:Androstanes / Q000032:analysis / Q000096:biosynthesis*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D011247:Pregnancy; D013057:Spectrum Analysis; D013261:Sterols / Q000096:biosynthesis
D015065:17-Hydroxycorticosteroids; D000731:Androstanes; D013261:Sterols