Capsid mosaics of intermediate strains of human adenoviruses.
Antisera against isolated capsid components of intermediate adenovirus strains, types 3-16 (the San Carlos agent) and 15-9 and of "parental" prototype strains were compared in neutralization tests, hemagglutination-inhibition (HI) tests employing soluble and virion-associated hemagglutinin as antigens, and by electron microscopy. Hexons of the intermediate strains were found to be similar to, but not identical to, those of the prototype strains with which a cross-reaction occurred in neutralization tests (types 3 and 15). In contrast, fibers of intermediate strains displayed characteristics relating them to the corresponding components of prototype strains to which a relationship has been found in HI tests. Fibers (and possibly even pentons) of types 9 and 15-9 appeared to be identical, whereas fibers of types 3-16 and 16 displayed antigen specificities of both common and unique nature.
D000256:Adenoviridae / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D000941:Antigens; D001853:Bone Marrow; D002460:Cell Line; D003168:Complement Fixation Tests; D004622:Embryo, Mammalian; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D008168:Lung; D008854:Microscopy, Electron; D009500:Neutralization Tests; D014764:Viral Proteins
D000941:Antigens; D014764:Viral Proteins