Bacterial interference with L-forms.
During the course of studying the effect of normal nasal flora on the growth of L-forms, a clear zone of inhibition was observed around colonies of many coagulase-negative staphylococci. Subsequent investigation demonstrated that Staphylococcus aureus and some S. albus strains produce a substance which is capable of markedly inhibiting the growth of stable staphylococcal and streptococcal L-forms. This interfering substance is separable from the staphylococcal organism and is diffusible through 1.5% agar, but not through a dialysis membrane. It is heat-stable.
D000596:Amino Acids / Q000494:pharmacology; D000898:Antibiosis; D002498:Centrifugation; D003470:Culture Media / Q000494:pharmacology; D003956:Dialysis; D005374:Filtration; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007740:L Forms / Q000254:growth & development*; D013210:Staphylococcus / Q000254:growth & development; D014815:Vitamins / Q000494:pharmacology
D000596:Amino Acids; D003470:Culture Media; D014815:Vitamins