m-Hydroxyphenylacetic acid formation from L-dopa in man: suppression by neomycin.
The increased excretion of m-hydroxyphenylacetic acid in the urine of patients with parkinsonism being treated with L-dopa was reduced by gut sterilization with neomycin. The p-de-hydroxylation step is thus brought about solely by the action of gut flora; the pathway is unlikely to be involved in the events within the brain leading to the therapeutic benefit effected by L-dopa.
D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000382:microbiology; D009355:Neomycin / Q000008:administration & dosage*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism* / Q000652:urine; D010648:Phenylacetates / Q000652:urine*
D010648:Phenylacetates; D004295:Dihydroxyphenylalanine; D009355:Neomycin