The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene.
Cholesterol is biosynthesized from squalene in the presence of tritiated water. Chemical degradation reveals that a considerable percentage of the total radioactivity is present at C-15. This result confirms the previous observations on the involvement of a C-15 hydrogen atom in cholesterol biosynthesis.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000096:biosynthesis*; D006859:Hydrogen / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008956:Models, Chemical; D051381:Rats; D013185:Squalene / Q000378:metabolism*; D014316:Tritium; D014867:Water / Q000378:metabolism
D014867:Water; D014316:Tritium; D013185:Squalene; D006859:Hydrogen; D002784:Cholesterol