Hepatic acetoacetyl-CoA deacylase activity in rats fed ethyl chlorophenoxyisobutyrate (CPIB).
Intact or sonicated mitochondria from the livers of rats fed a diet containing 0.2% ethyl chlorophenoxyisobutyrate (CPIB) for 3 wk showed acetoacetyl-CoA deacylase activity enhanced 26 and 39%, respectively, over that shown by comparable fractions from rats fed the same diet without CPIB. The corresponding supernatant fractions did not differ in activity. The enhanced activity of mitochondrial acetoacetyl-CoA deacylase in the livers of the CPIB-treated rats could effectively decrease the amount of acetoacetyl CoA available within the cell for synthetic processes.
D000085:Acetates / Q000378:metabolism; D000090:Acetoacetates; D000577:Amides; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D002247:Carbon Isotopes; D002784:Cholesterol / Q000096:biosynthesis*; D003065:Coenzyme A; D004950:Esterases / Q000378:metabolism*; D005977:Glutarates; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D011422:Propionates / Q000494:pharmacology*; D051381:Rats
D000085:Acetates; D000090:Acetoacetates; D000577:Amides; D000924:Anticholesteremic Agents; D002247:Carbon Isotopes; D005977:Glutarates; D011422:Propionates; D002784:Cholesterol; D004950:Esterases; D003065:Coenzyme A