Sodium-dependent accumulation of 5-hydroxytryptamine by rat blood platelets.
1. The influence of sodium and potassium on the accumulation of 5-hydroxytryptamine (5-HT) by rat blood platelets was investigated.2. An absolute dependence of 5-HT uptake on the sodium concentration in the medium was found.3. Removal of potassium reduced the uptake by about 60%. High concentrations of potassium inhibited sodium-dependent accumulation.4. The observations have been discussed in terms of a carrier-mediated transport process for 5-HT operating in the platelet membrane.
D000818:Animals; D001693:Biological Transport, Active; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D011188:Potassium / Q000032:analysis / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012964:Sodium / Q000032:analysis / Q000494:pharmacology*; D014316:Tritium
D014316:Tritium; D012701:Serotonin; D012964:Sodium; D011188:Potassium