Cystine: compartmentalization within lysosomes in cystinotic leukocytes.
The large amount of cystine compartmentalized in cystinotic leukocytes cosediments in isopycnic sucrose density gradients with dense lysosomal particles, within which it is presumably contained. Such cystine appears to be primarily noncrystalline in these organelles.
D002499:Centrifugation, Density Gradient; D003545:Cysteine / Q000494:pharmacology; D003553:Cystine / Q000097:blood*; D003554:Cystinosis / Q000097:blood*; D006801:Humans; D007962:Leukocytes / Q000166:cytology*; D008247:Lysosomes / Q000032:analysis* / Q000201:enzymology; D013395:Sucrose; D013460:Sulfur Isotopes
D013460:Sulfur Isotopes; D003553:Cystine; D013395:Sucrose; D003545:Cysteine