Bioactivation of 5-oxo-(D-trans-2-phenylcyclopropyl)-L-2-pyrrolidone carboxamide (EX 4883) into a monoamine oxidase inhibitor by a soluble fraction enzyme system.
D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism / Q000494:pharmacology*; D001669:Biochemical Phenomena; D001671:Biochemistry; D001923:Brain Chemistry; D004789:Enzyme Activation; D007668:Kidney / Q000032:analysis; D008110:Liver Extracts / Q000032:analysis; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D014020:Tissue Extracts / Q000032:analysis
D000928:Antidepressive Agents; D008110:Liver Extracts; D008996:Monoamine Oxidase Inhibitors; D011760:Pyrrolidinones; D014020:Tissue Extracts; D008995:Monoamine Oxidase