Virulence of temperature-sensitive mutants of influenza virus.
The acquisition of temperature-mutant (ts) defects in a strain of influenza virus has been shown in mice to be associated with diminished virulence, though the antibody-producing stimulus remained. It is suggested that three advantages may make ts strains potential sources of attenuated live influenza vaccine-the ease of obtaining the strains, the ease of testing the vaccine strain, and the high yield of vaccine doses from a single egg.
D000818:Animals; D000917:Antibody Formation; D006385:Hemagglutination Inhibition Tests; D007252:Influenza Vaccines; D051379:Mice; D009154:Mutation; D009975:Orthomyxoviridae / Q000472:pathogenicity*; D013045:Species Specificity; D013696:Temperature; D014774:Virulence
D007252:Influenza Vaccines