Pseudohermaphrodite rat: end organ insensitivity to testosterone.
The pseudohermaphrodite rat is characterized by lack of androgen-dependent differentiation. Treatment of these rats with testosterone failed to produce the expected changes in preputial and adrenal gland weights and hexobarbital metabolism. This insitivity of the end organ to testosterone could not be explained by defective formation of dihydrotestosterone.
D000311:Adrenal Glands / Q000187:drug effects; D013734:Androgen-Insensitivity Syndrome / Q000378:metabolism; D000818:Animals; D002247:Carbon Isotopes; D004195:Disease Models, Animal; D012734:Disorders of Sex Development / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D005837:Genitalia, Male / Q000187:drug effects; D006591:Hexobarbital / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects; D051381:Rats; D013739:Testosterone / Q000378:metabolism
D002247:Carbon Isotopes; D013739:Testosterone; D006591:Hexobarbital