Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians.
A high frequency of Hb J Tongariki (alpha 115 Ala --> Asp) was found in a Kilenge village in New Britain. Heterozygotes had 45 to 50 percent of the Hb J component (determined by cellulose acetate electrophoresis). Two homozygotes for Hb J had no Hb A, suggesting that in this family only one Hbalpha structural locus is present.
D000596:Amino Acids / Q000032:analysis; D001797:Blood Protein Electrophoresis; D002918:Chymotrypsin; D004913:Erythrocytes, Abnormal; D005796:Genes; D005828:Genetics, Population; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006720:Homozygote; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008542:Melanesia; D010375:Pedigree; D010455:Peptides / Q000032:analysis*; D014357:Trypsin
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D010455:Peptides; D002918:Chymotrypsin; D014357:Trypsin