Polyinosinic-polycytidylic acid inhibits chemically induced tumorigenesis in mouse skin.
Polyinosinic-polycytidylic acid administered intraperitoneally inhibits (i) the formation of skin tumors induced by a single topical application of 9,10-dimethylbenzanthracene followed by weekly applications of croton oil and (ii) the formation of skin tumors induced by a single large application of 9,10-dimethylbenzanthracene.
D000818:Animals; D001551:Benz(a)Anthracenes; D003436:Croton Oil; D007166:Immunosuppressive Agents; D007274:Injections, Intraperitoneal; D051379:Mice; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D011119:Polynucleotides / Q000138:chemical synthesis / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D001551:Benz(a)Anthracenes; D007166:Immunosuppressive Agents; D011119:Polynucleotides; D003436:Croton Oil