Regression curve analysis of cephalosporin activity.
Regression lines were calculated for cephalothin, cephalexin, and cephaloridine by relating zone diameters of inhibition to minimal inhibitory concentrations (MIC) obtained in Mueller-Hinton agar and in Trypticase Soy Agar. A regression line was calculated for cephaloglycin by obtaining MIC values in Trypticase Soy Agar at pH 6.6. Regression lines calculated from MIC values in Mueller-Hinton agar were practically superimposable on those based on MIC values in Trypticase Soy Agar. Organisms susceptible by disc testing to cephalothin were usually susceptible to cephalexin and cephaloridine.
D000362:Agar; D001407:Bacillus / Q000187:drug effects; D002509:Cephaloridine / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology*; D003470:Culture Media; D004755:Enterobacteriaceae / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects; D013223:Statistics as Topic; D013291:Streptococcus / Q000187:drug effects
D002511:Cephalosporins; D003470:Culture Media; D000362:Agar; D002509:Cephaloridine; D002512:Cephalothin