Recrudescence of H. influenzae meningitis after therapy with ampicillin. Late recurrence may result from diminishing levels of ampicillin in the cerebrospinal fluid secondary to decreasing meningeal permeability and too early reduction in dose.
D000667:Ampicillin / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D001812:Blood-Brain Barrier; D002908:Chronic Disease; D006801:Humans; D007223:Infant; D008297:Male; D008578:Meninges; D008583:Meningitis, Haemophilus / Q000188:drug therapy*; D010539:Permeability
D000667:Ampicillin