Hundred day leukemia: preferential induction in rat by pulse-doses of 7,8,12-trimethylbenz(a)anthracene.
A series of pulse-doses of 7, 8, 12-trimethylbenz(a)anthracene-induced leukemia rapidly and consistently in very high yield in rats of Long-Evans (L-E) strain. The predominant type was a diffuse hepatic leukemia of erythroblastic stem cells. Progressive hypothermia and a decline in pituitary function are newly recognized signs of advanced leukemia in rat.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000009:adverse effects*; D004912:Erythrocytes / Q000503:physiopathology; D007035:Hypothermia; D007037:Hypothyroidism; D007942:Leukemia, Experimental / Q000139:chemically induced*; D008107:Liver Diseases / Q000097:blood* / Q000473:pathology; D051381:Rats
D001551:Benz(a)Anthracenes