Effect of RA233 on platelet function in vitro.
RA233, a new pyrimido-pyrimidine compound, is a powerful inhibitor of platelet function tested in vitro; it inhibits calcium and adenosine diphosphate (A.D.P.)-induced platelet aggregation, inhibits the retention of platelets by glass beads, decreases the release of platelet factor 3 by kaolin, and inhibits clot retraction. In some in-vitro systems RA233 is significantly more potent that its analogue RA433 in inhibiting platelet function.
D000227:Adenine Nucleotides / Q000037:antagonists & inhibitors; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects*; D002118:Calcium / Q000037:antagonists & inhibitors; D005898:Glass; D006801:Humans; D066298:In Vitro Techniques; D007616:Kaolin; D010973:Platelet Adhesiveness / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology*
D000227:Adenine Nucleotides; D001779:Blood Coagulation Factors; D011743:Pyrimidines; D007616:Kaolin; D002118:Calcium