Proinsulin: metabolic effects in the human forearm.
Five subjects were studied by the forearm perfusion technique with proinsulin at a final plasma conceintration of 1.76 x 10(-9) millimole per milliliter. Two of these subjects were studied with single-component insulin at a concentration of 1.96 x 10(-9) millimole per milliliter. Proinsulin is, in general, biologically less potent than single-component insulin. In contrast to insulin, its effects upon adipose tissue are for the most part greater than upon muscle.
D000273:Adipose Tissue / Q000378:metabolism; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005542:Forearm / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism; D010477:Perfusion; D011188:Potassium / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D011188:Potassium