Cytogenetic studies of leukemia induced by 6,8,12-and 7,8,12-trimethylbenz(a)anthracene.
Cytogenetic studies on 64 rat leukemias induced with 7,8,12- and 6,8,12-trimethylbenz(a)anthracene were performed. Highly distinctive changes were found repeatedly in one special pair of chromosomes. 10 leukemias (15.6%) showed the presence of stemline(s) with trisomy of the largest telocentric chromosome (C-1 trisomy). Another chromosome abnormality, elongation of one of the pairs of the same chromosome (long C-1), was found in 5 leukemias (7.8%) as the predominant stemline and in 7 other cases as a small cell population. This chromosome abnormality, despite slight differences in their elongation rate, was defined as a new specific chromosome abnormality. Other chromosome abnormalities not related with C-1 chromosome were found in 8 cases (12.5%). The remaining 41 leukemias (64.1%) had the predominant stemline with normal karyotype. From this study it appears that three structurally different hydrocarbon carcinogens, 7,12-dimethylbenz(a)anthracene and 7,8,12- and 6,8,12-trimethylbenz(a)anthracene act on blood-forming cells by a common specific mechanism.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000009:adverse effects*; D001773:Blood Cells; D002869:Chromosome Aberrations / Q000139:chemically induced*; D025063:Chromosome Disorders; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000139:chemically induced; D051381:Rats; D014314:Trisomy
D001551:Benz(a)Anthracenes