Polyinosinic acid--polycytidylic acid: inhibition of DNA synthesis stimulated by isoproterenol.
Polyinosinic acid * polycytidylic acid (poly I * poly C) inhibits isoproterenol-stimulated DNA synthesis in salivary glands of mice. A single intraperitoneal injection of 250 micrograms of poly I * poly C inhibits the stimulation of DNA synthesis when given 10 minutes before isoproterenol or at any time during the 20-hour lag period between the injection of isoproterenol and the subsequent DNA synthesis. The inhibition caused by poly I * poly C is not due to a generalized toxic action but seems to be exerted through a relatively selective mechanism. Polyuridylic acid and diethylaminoethyl dextran are less effective in inhibiting isoproterenol-stimulated DNA synthesis.
D000818:Animals; D004261:DNA Replication / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007545:Isoproterenol / Q000037:antagonists & inhibitors*; D051379:Mice; D011119:Polynucleotides / Q000138:chemical synthesis / Q000494:pharmacology*; D012313:RNA / Q000138:chemical synthesis; D012469:Salivary Glands / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D011119:Polynucleotides; D014316:Tritium; D012313:RNA; D007545:Isoproterenol; D013936:Thymidine