Hydroxyurea: suppression of two-stage carcinogensis in mouse skin.
Hydroxyurea, a selective cytotoxic agent for cells in DNA synthesis, injected intraperitoneally at 24 and 48 hours after the first painting with 1 percent croton oil, significantly reduced the tumor yield in the two-stage chemical carcinlogenesis in mouse skin. A comparable group of mice receiving hydroxyurea only once at 24 hours had a tumor induction similar to that in controls.
D000818:Animals; D003436:Croton Oil; D006918:Hydroxyurea / Q000008:administration & dosage*; D051379:Mice; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D010212:Papilloma / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D003436:Croton Oil; D006918:Hydroxyurea