Bradykinin inhibition by butylated hydroxyanisole.
Concentrations of butylated hydroxyanisole as low as 8 x 10(-9) mole per liter can inhibit detectably the contraction of smooth muscle elicited by bradykinin. The mechanism of the inhibitory effect of this food grade anti-oxidant is apparently complex, and the effect is only partially reversible.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001920:Bradykinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005519:Food Preservation; D006168:Guinea Pigs; D006873:Hydroquinones / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*
D000975:Antioxidants; D006873:Hydroquinones; D001920:Bradykinin