Hyperbaric oxygen: effects on metabolism and ionic movement in cerebral cortex slices.
The incubation of slices of cerebral cortex under hyperbaric oxygen pressures from 1 to 10 atmospheres in the presence of radioactive glucose, pyruvate, succinate, fumarate, L-glutamate, and gamma-aminobutyric acid causes a marked diminution of tissue oxidative reactions. There is a simultaneous decrease in phosphocreatine and adenosine triphosphate, and a reduction of the apparent intracellular ionic gradients. The increase of lipid peroxides, measured directly, is attributed to the toxic effects of hyperbaric oxygen.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000613:Aminobutyrates / Q000378:metabolism; D000818:Animals; D001274:Atmospheric Pressure; D002247:Carbon Isotopes; D002540:Cerebral Cortex / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D006168:Guinea Pigs; D006931:Hyperbaric Oxygenation; D010101:Oxygen Consumption; D011188:Potassium / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013386:Succinates / Q000378:metabolism
D000613:Aminobutyrates; D002247:Carbon Isotopes; D005971:Glutamates; D011773:Pyruvates; D013386:Succinates; D000255:Adenosine Triphosphate; D012964:Sodium; D005947:Glucose; D011188:Potassium