The possible role of adenosine in the coronary dilator action of some pyrimidopyrimidines and pteridines.
1. The abilities of some pyrimidopyrimidines (including dipyridamole) and pteridine derivatives to potentiate heart block produced by adenosine in the guinea-pig and to produce coronary dilatation in kitten hearts were investigated.2. The results demonstrated a correlation between adenosine potentiating and coronary dilating activities of the compounds studied, and are therefore compatible with the concept that compounds of the dipyridamole type owe their coronary dilator activity to potentiation of endogenous adenosine.
D000818:Animals; D002415:Cats; D003331:Coronary Vessels / Q000187:drug effects*; D004176:Dipyridamole / Q000494:pharmacology*; D004357:Drug Synergism; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D006327:Heart Block / Q000139:chemically induced; D066298:In Vitro Techniques; D009705:Nucleosides / Q000494:pharmacology*; D011621:Pteridines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology
D009705:Nucleosides; D011621:Pteridines; D011743:Pyrimidines; D014665:Vasodilator Agents; D004176:Dipyridamole