Tolerance to polyinosinic-polycytidylic acid in NZB-NZW mice.
Immunological tolerance to polyinosinic * polycytidylic acid was induced in NZB/ NZW mice. This is the first experimental induction of tolerance to a nucleic antigen.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D003597:Cytosine Nucleotides / Q000494:pharmacology; D004195:Disease Models, Animal; D007108:Immune Tolerance / Q000187:drug effects*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D009696:Nucleic Acids / Q000494:pharmacology*; D011119:Polynucleotides / Q000494:pharmacology*; D012313:RNA / Q000138:chemical synthesis
D003597:Cytosine Nucleotides; D009696:Nucleic Acids; D011119:Polynucleotides; D012313:RNA; D003520:Cyclophosphamide