Amantadine-dopamine interaction: possible mode of action in Parkinsonism.
Intravenous doses of amantadine hydrochloride, an antiviral drug, as small as 0.08 milligram per kilogram may release dopamine and other catecholamines from neuronal storage sites in dogs primed with dopamine. This release may account for the reported efficacy of amantadine hydrochloride in the treatment of human parkinsonism.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000547:Amantadine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004298:Dopamine / Q000378:metabolism* / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D013268:Stimulation, Chemical; D014628:Vagotomy
D001285:Atropine; D000547:Amantadine; D000109:Acetylcholine; D004298:Dopamine