Drug intoxication and neurological episodes in chronic renal failure.
Of 178 episodes of neurological derangement in 103 patients with renal failure, only about 40% were due to known causes such as hypertension or electrolyte failure. One-third were due to drug intoxication and no definite aetiology was found for the remainder. Drug intoxication is due partly to the accumulation of a drug normally excreted by the kidney and partly to a greater susceptibility of the central nervous system in uraemic patients. The prognosis is favourable.
D002561:Cerebrovascular Disorders / Q000139:chemically induced; D003128:Coma / Q000139:chemically induced; D003638:Deafness / Q000139:chemically induced; D064420:Drug-Related Side Effects and Adverse Reactions; D005116:Extrapyramidal Tracts; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D009069:Movement Disorders / Q000139:chemically induced; D009422:Nervous System Diseases / Q000139:chemically induced*; D009460:Neurologic Examination; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D012640:Seizures / Q000139:chemically induced