Effects of omega-amino acids and related compounds on staphylococcal infections in mice: a combined prophylactic-therapeutic procedure.
By a short-term combined prophylactic-therapeutic procedure, the following compounds were found to be active against staphylococcal infections in Swiss mice: gamma-aminobutyric acid, gamma-amino-beta-hydroxybutyric acid (GABOB), delta-amino-valeric acid (DAVA), epsilon-aminocaproic acid (EACA), trans-4-aminomethylcyclohexanecarboxylic acid (trans-AMCHA), taurine, and cysteic acid. Many of these compounds had displayed limited or no activity by a previously used prophylactic procedure. Although DAVA and GABOB were the most potent of the straight-chain omega-amino acids, trans-AMCHA displayed the greatest antistaphylococcic activity of the omega-amino acids thus far investigated. Homocarnosine (gamma-aminobutyrl histidine, which also was active by the prophylactic procedure) equalled trans-AMCHA in activity. Taurine was similar in potency to DAVA, and the activity of cysteic acid approximated that of EACA.
D000409:Alanine / Q000627:therapeutic use; D000596:Amino Acids / Q000627:therapeutic use*; D000613:Aminobutyrates / Q000627:therapeutic use; D000614:Aminocaproates / Q000627:therapeutic use; D000818:Animals; D003470:Culture Media; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use; D003545:Cysteine / Q000627:therapeutic use; D004151:Dipeptides / Q000627:therapeutic use; D005260:Female; D005998:Glycine / Q000627:therapeutic use; D006639:Histidine / Q000627:therapeutic use; D006885:Hydroxybutyrates / Q000627:therapeutic use; D007279:Injections, Subcutaneous; D051379:Mice; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013210:Staphylococcus; D013441:Sulfinic Acids / Q000627:therapeutic use; D013654:Taurine / Q000627:therapeutic use; D014631:Valerates / Q000627:therapeutic use
D000596:Amino Acids; D000613:Aminobutyrates; D000614:Aminocaproates; D003470:Culture Media; D003509:Cyclohexanecarboxylic Acids; D004151:Dipeptides; D006885:Hydroxybutyrates; D013441:Sulfinic Acids; D014631:Valerates; D013654:Taurine; D006639:Histidine; D003545:Cysteine; D000409:Alanine; D005998:Glycine