Cystic fibrosis: characterization of the inhibitor to ciliary action in oyster gills.
The inhibitor to oyster ciliary activity was isolated from serumof cystic fibrosis patients and heterozygotes. The inhibitinig protein fraction wast a cation as judged by electrophoresis; it had a molecuer weight of 125,000 to 200,000 as judged by gel filtration; antd oil diethylaminoethyl-cellulose chromatography it eluted with the immunoglobulin G fraction. The analogous fraction in normal individuals did not inhibit oyster cillary activity.
D000818:Animals; D001797:Blood Protein Electrophoresis; D002850:Chromatography, Gel; D002923:Cilia / Q000187:drug effects*; D003550:Cystic Fibrosis / Q000097:blood*; D005880:Gills / Q000187:drug effects*; D006579:Heterozygote; D006801:Humans; D007074:Immunoglobulin G; D008970:Molecular Weight; D008974:Mollusca; D014020:Tissue Extracts / Q000494:pharmacology*
D007074:Immunoglobulin G; D014020:Tissue Extracts