Impairment of shock avoidance learning after long-term alcohol ingestion in mice.
Chronic alcohol consumption impaired the learning of a two-way shuttle box avoidance task in mice 10 to 14 days after the discontinuation of ethanol in the diet. Control groups received laboratory chow ad libitum or were pair-fed with the alcohol-consuming mice by diets containing isocaloric amounts of sucrose. The performance of the two control groups was indistinguishable from each other, and only the ethanol-consuming mice performed poorly. It was therefore concluded that alcohol consumption per se and not a nutritional deficiency was responsible for the impairment of learning.
D000704:Analysis of Variance; D000818:Animals; D001244:Association / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects; D003864:Depression, Chemical; D004597:Electroshock; D004924:Escape Reaction / Q000187:drug effects*; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D005260:Female; D051379:Mice; D013312:Stress, Physiological / Q000503:physiopathology; D013395:Sucrose / Q000097:blood
D000431:Ethanol; D013395:Sucrose