Bladder cancer induction by aromatic amines: role of N-hydroxy metabolites.
Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-naphthylamine, and 4-aminobiphenyl with both methemoglobin production in the blood and concentration of N-oxidation products in the urine. Thus, N-hydroxylation appears to be the key to bladder cancer production by aromatic amines.
D000588:Amines / Q000378:metabolism*; D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D004285:Dogs; D008708:Methemoglobinemia / Q000139:chemically induced; D009281:Naphthalenes / Q000378:metabolism; D010084:Oxidation-Reduction; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D000588:Amines; D002273:Carcinogens; D009281:Naphthalenes