Mixed lymphocyte cultures produce effector cells: model in vitro for allograft rejection.
Mouse peripheral lymphocytes sensitized in vitro by culturing with allogeneic lymphocytes produced immunospecific destruction of target cells, as measured by release of chromium-51. Thus the sensitizing and effector phases of the cell-bound immune response can both be studied in an in vitro system.
D000818:Animals; D002859:Chromium Isotopes; D046508:Culture Techniques; D006648:Histocompatibility; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008954:Models, Biological; D013936:Thymidine / Q000378:metabolism; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014316:Tritium
D002859:Chromium Isotopes; D014316:Tritium; D013936:Thymidine