Oncogenic purine derivatives: evidence for a possible proximate oncogen.
Two additional urinary metabolites of the chemical oncogen 3-hydroxyxanthine are now identified as 8-chloroxanthine and 8-methylmercaptoxanthine. Such products are thought to be derived from a reactive intermediate which can be tentatively considered to be a proximate oncogen. Since each of these 8-substituted xanthines has also been obtained in vitro by reactions of 3-acetoxyxanthine with chloride ion or methionine, their production in vivo can be explained as resulting through the metabolic formation of an activated ester with a reactivity similar to that of the chemical model.
D000818:Animals; D002247:Carbon Isotopes; D002273:Carcinogens / Q000378:metabolism / Q000652:urine*; D002852:Chromatography, Ion Exchange; D002854:Chromatography, Paper; D008956:Models, Chemical; D051381:Rats; D014970:Xanthines / Q000378:metabolism / Q000652:urine*
D002247:Carbon Isotopes; D002273:Carcinogens; D014970:Xanthines