Cerebral acid hydrolase activities: comparison in "quaking" and normal mice.
The activity of several acid hydrolase enzymes was determined in whole brain homogenates of adult "quaking" and normal mice. A striking decrease was found in alpha-mannosidase and, to a lesser extent, aryl sulfatase levels in the samples from the mutant animals. The activities of the other "lyso-somal" enzymes were only slightly lowered.
D000818:Animals; D001923:Brain Chemistry; D006026:Glycoside Hydrolases / Q000032:analysis*; D006867:Hydrolases / Q000032:analysis*; D051379:Mice; D009069:Movement Disorders / Q000201:enzymology; D009186:Myelin Sheath / Q000502:physiology; D014202:Tremor / Q000201:enzymology* / Q000235:genetics
D006867:Hydrolases; D006026:Glycoside Hydrolases