Mercury poisoning: prevention by spironolactone.
The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone.
D058186:Acute Kidney Injury / Q000188:drug therapy*; D000818:Animals; D002614:Chelating Agents; D004112:Dimercaprol / Q000627:therapeutic use; D005260:Female; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology*; D008630:Mercury Poisoning / Q000188:drug therapy*; D009336:Necrosis; D009397:Nephrocalcinosis / Q000188:drug therapy*; D051381:Rats; D013148:Spironolactone / Q000627:therapeutic use*; D013256:Steroids / Q000627:therapeutic use; D013438:Sulfhydryl Compounds / Q000627:therapeutic use
D002614:Chelating Agents; D013256:Steroids; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D013148:Spironolactone