Urinary hydroxyproline in the elderly with low leucocyte ascorbic acid levels.
Fourteen elderly patients aged 58 to 91 with varying leucocyte ascorbic acid levels had urinary hydroxyproline/creatinine ratios measured before, during, and after treatment with ascorbic acid 1 g. daily for six days. The ratio increased during treatment in those patients whose initial ascorbic acid levels were below 15mug./10(8) white blood cells. It is suggested that collagen metabolism may be impaired in these patients, and that all such patients should receive ascorbic acid supplements.
D000368:Aged; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood*; D001206:Ascorbic Acid Deficiency / Q000378:metabolism / Q000652:urine*; D003094:Collagen / Q000378:metabolism; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D007962:Leukocytes / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D003094:Collagen; D003404:Creatinine; D001205:Ascorbic Acid; D006909:Hydroxyproline