Polypeptide with broad biological activity: isolation from small intestine.
A polypeptide, which has potent and diverse biological action-including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia-was isolated from the small intestine of the hog. The peptide has 28 amino acid residues and is chemically distinct from the kinins, "substance P," glucagon, and secretin.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003377:Countercurrent Distribution; D005768:Gastrointestinal Hormones / Q000302:isolation & purification / Q000494:pharmacology*; D005934:Glucagon; D007421:Intestine, Small; D007705:Kinins; D010455:Peptides / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D012633:Secretin; D013268:Stimulation, Chemical; D013373:Substance P; D013552:Swine; D014665:Vasodilator Agents / Q000494:pharmacology
D000596:Amino Acids; D005768:Gastrointestinal Hormones; D007705:Kinins; D010455:Peptides; D014665:Vasodilator Agents; D012633:Secretin; D013373:Substance P; D005934:Glucagon