Heritable fragile site on chromosome 16: probable localization of haptoglobin locus in man.
We have found recurrent chromosome breaks at a site (the "fragile site") on the long arm of chromosome 16. This site segregates in simple Mendelian dominant fashion in a large family. The distal portion of the chromosome sometimes shows selective endoreduplication. Preliminary linkage results reveal only 3 recombinants in 33 opportunities for recombination between the fragile site and the alpha locus of haptoglobin, an indication that the alpha-Hp gene is located near this region on chromosome 16.
D000293:Adolescent; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002902:Chromosomes, Human, 16-18; D046508:Culture Techniques; D006242:Haptoglobins / Q000032:analysis*; D006648:Histocompatibility; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
D006242:Haptoglobins