1,3-Bis(p-chlorobenzylideneamino)guanidine hydrochloride (robenzidene): new poultry anticoccidial agent.
At 66 parts per million in the feed, robenzidene is highly effective in preventing chicken coccidiosis caused by any one of eight Eimeria species. Three times this dose is safe for broiler chickens. In dogs and rats, the toxicity was relatively low over a period of 90 days. In laboratory trials, the drug completely prevents oocyst production by seven species and greatly reduces oocyst production by Eimeria maxima.
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use* / Q000633:toxicity; D001835:Body Weight; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy* / Q000401:mortality; D004285:Dogs; D006146:Guanidines / Q000627:therapeutic use* / Q000633:toxicity; D008288:Malaria / Q000188:drug therapy; D011201:Poultry Diseases / Q000188:drug therapy*; D051381:Rats
D000981:Antiprotozoal Agents; D006146:Guanidines