Induction of kynureninase in Neurospora.
Induction of kynureninase in a homogeneous population of mycelia in balanced growth was studied. Induced synthesis of enzyme was apparent 10 min after addition of inducers (tryptophan, kynurenine, and N-formylkynurenine). Experiments with cycloheximide-inhibited cells indicated that initiation of message transcription occurred about 4 min after addition of inducers. Lifetime of the message in the absence of inducer was of the order of 5 min. Experiments with mutants showed that N-formylkynurenine was the probable inducer of physiological importance.
D003513:Cycloheximide / Q000494:pharmacology; D004790:Enzyme Induction; D006867:Hydrolases / Q000378:metabolism*; D007737:Kynurenine / Q000494:pharmacology; D009491:Neurospora / Q000187:drug effects / Q000201:enzymology*; D012333:RNA, Messenger / Q000096:biosynthesis; D014364:Tryptophan / Q000494:pharmacology
D012333:RNA, Messenger; D007737:Kynurenine; D014364:Tryptophan; D003513:Cycloheximide; D006867:Hydrolases