Orotidinuria induced by allopurinol.
The administration of allopurinol to patients suffering from hyperuricemia and to normal subjects results in increased excretion of the pyrimidine nucleoside orotidine. Evidence is presented for the interference by allopurinol of the de novo biosynthesis of uridine 5'-phosphate in man.
D000493:Allopurinol / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D003124:Colorimetry; D003864:Depression, Chemical; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D009705:Nucleosides / Q000652:urine*; D014166:Transferases / Q000037:antagonists & inhibitors; D014227:Triazines / Q000494:pharmacology; D014500:Uracil Nucleotides / Q000096:biosynthesis*
D009705:Nucleosides; D014227:Triazines; D014500:Uracil Nucleotides; D000493:Allopurinol; D014166:Transferases