Ochratoxin A: inhibition of mitochondrial respiration.
Ochratoxin A is a fungal metabolite which induces pathological changes in animals. The toxin was isolated from cultures of Aspergillus ochraceus and purified by thin-layer chromatography. Ochratoxin A and one of its hydrolysis products, dihydroisocoumarin, severely inhibited coupled respiration when applied at low concentration to rat liver mitochondria.
D000818:Animals; D001230:Aspergillus / Q000032:analysis*; D002855:Chromatography, Thin Layer; D003374:Coumarins / Q000494:pharmacology; D005260:Female; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D009183:Mycotoxins / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
D003374:Coumarins; D009183:Mycotoxins