Intestinal hydrolysis and conjugation of a pesticidal carbamate in vitro.
The metabolite 1-[1-(14)C]naphthyl glucuronide was isolated from mucosal and serosal fluids of everted sacs of rat small intestine incubated in media containing either the insecticide 1-[1-(14)C]naphthyl N-methylcarbamate (carbaryl) or 1-[1-(14)C]naphthol. The hydrolysis of carbaryl and conjugation of the liberated naphthol indicated some degree of metabolism by the intestine before absorption.
D000818:Animals; D001711:Biotransformation; D002219:Carbamates / Q000378:metabolism*; D002247:Carbon Isotopes; D005965:Glucuronates / Q000378:metabolism; D066298:In Vitro Techniques; D007306:Insecticides / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D009281:Naphthalenes / Q000378:metabolism*; D051381:Rats; D012704:Serous Membrane / Q000378:metabolism
D002219:Carbamates; D002247:Carbon Isotopes; D005965:Glucuronates; D007306:Insecticides; D009281:Naphthalenes