Turnover of the brain specific protein, S-100.
Rats were killed after intraventricular administration of [(3)H]leucine, and the turnover rates of total soluble proteins and of the brain specific S-100 protein were determined. The half-life of S-100 was estimated to be 16 days. The S-100 protein, thus, has a turnover not unlike that of the average water-soluble protein of brain.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002848:Chromatography, DEAE-Cellulose; D004589:Electrophoresis, Disc; D007930:Leucine / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014316:Tritium
D009419:Nerve Tissue Proteins; D014316:Tritium; D007930:Leucine