Impaired glucose tolerance: a late effect of insulin shock treatment.
Glucose tolerance tests were performed in a group of patients in a mental hospital who had been treated with insulin shock and in a matched control group. Five out of 31 (16%) patients in the insulin-treated group and 1 out of 22 (5%) controls had "diabetic" blood sugar curves. Median blood sugar values were significantly higher at 60 minutes and later in the insulin-treated group, as were mean blood sugar values when the "diabetic" patients were excluded. Small amounts of plasma insulin-binding antibody were found in two insulin-treated patients. In the absence of any other clear-cut explanation, it is suggested that in some patients massive doses of insulin by injection may leave diminished tissue responsiveness to insulin as a long-term after-effect.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003295:Convulsive Therapy / Q000009:adverse effects*; D003920:Diabetes Mellitus / Q000139:chemically induced; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007330:Insulin Antibodies / Q000032:analysis; D008297:Male; D001523:Mental Disorders / Q000628:therapy; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies