Reversal by vitamin K of cycloheximide inhibited biosynthesis of prothrombin in the isolated perfused rat liver.
D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis; D002247:Carbon Isotopes; D003513:Cycloheximide / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003864:Depression, Chemical; D066298:In Vitro Techniques; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008660:Metabolism / Q000187:drug effects; D010477:Perfusion; D014176:Protein Biosynthesis; D011516:Prothrombin / Q000096:biosynthesis*; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D012270:Ribosomes / Q000378:metabolism; D013268:Stimulation, Chemical; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000494:pharmacology*; D014813:Vitamin K Deficiency / Q000378:metabolism
D001798:Blood Proteins; D002247:Carbon Isotopes; D011691:Puromycin; D010837:Vitamin K 1; D011516:Prothrombin; D003513:Cycloheximide; D007930:Leucine