Catecholamine biosynthesis in brains of rats treated with morphine.
In the brains of rats without tolerance to morphine, the accumulation of [(14)C]dopamine formed from [(14)C]tyrosine injected intracisternally is increased, reaching a maximum in the hypothalamus and striatum 1 hour after administration of morphine. In tolerant rats, the rate of incorporation of carbon-14 into dopamine and into norepinephrine in these areas is more than twice that in animals that have received only one injection of morphine.
D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D004295:Dihydroxyphenylalanine / Q000096:biosynthesis*; D004298:Dopamine / Q000096:biosynthesis*; D004361:Drug Tolerance; D007031:Hypothalamus / Q000378:metabolism; D009020:Morphine / Q000494:pharmacology*; D009638:Norepinephrine / Q000096:biosynthesis*; D051381:Rats; D014316:Tritium; D014443:Tyrosine / Q000378:metabolism
D002247:Carbon Isotopes; D014316:Tritium; D014443:Tyrosine; D004295:Dihydroxyphenylalanine; D009020:Morphine; D004298:Dopamine; D009638:Norepinephrine