Norepinephrine turnover and metabolism in rat brain after long-term administration of imipramine.
The rate of disappearance of intracisternally administered tritiated norepinephrine from rat brain is decreased after a single dose of the tricyclic antidepressant imipramine. During long-term administration of imipramine, however, the rate of disappearance of tritiated norepinephrine from brain gradually increases, and there is a concurrent decrease in the content of endogenous norepinephrine in brain. These findings may help to explain why antidepressant effects are observed clinically only after long-termn treatment with imipramine.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005246:Feedback; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D009647:Normetanephrine / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014316:Tritium; D014642:Vanilmandelic Acid / Q000378:metabolism
D009647:Normetanephrine; D014316:Tritium; D014642:Vanilmandelic Acid; D007099:Imipramine; D009638:Norepinephrine