Allopurinol: alteration in pyrimidine metabolism in man.
In addition to its well-established inhibitory effect on uric acid synthesis, allopurinol appears to alter substantially pyrimidine metabolism, as evidenced by a striking increase in the urinary excretion of orotidine and orotic acid. Allopurinol ribonucleotide and xanthosine 5'-monophosphate are potent inhibitors of human erythrocyte orotidylic decarboxylase and provide a possible mechanism for this effect.
D000493:Allopurinol / Q000494:pharmacology* / Q000627:therapeutic use; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D004912:Erythrocytes / Q000201:enzymology; D006073:Gout / Q000188:drug therapy; D006801:Humans; D007042:Hypoxanthines / Q000652:urine; D007700:Kinetics; D009705:Nucleosides / Q000652:urine; D009711:Nucleotides; D009963:Orotic Acid / Q000652:urine; D011743:Pyrimidines / Q000378:metabolism; D014527:Uric Acid / Q000652:urine; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors; D014970:Xanthines / Q000652:urine
D007042:Hypoxanthines; D009705:Nucleosides; D009711:Nucleotides; D011743:Pyrimidines; D014970:Xanthines; D014527:Uric Acid; D009963:Orotic Acid; D000493:Allopurinol; D014969:Xanthine Oxidase; D002262:Carboxy-Lyases