Effect of trimethoprim-sulphamethoxazole on typhoid and salmonella carriers.
Four chronic typhoid carriers from the Aberdeen typhoid outbreak of 1964 were treated with trimethoprim-sulphamethoxazole. The male carrier remained clear of infection following treatment but the three female carriers, all with gall bladder abnormalities, remained excretors. A convalescent typhoid excretor also remained clear of infection after treatment as well as two other salmonella carriers, one of whom has been a chronic carrier for 24 years.
D000328:Adult; D000368:Aged; D002353:Carrier State / Q000188:drug therapy*; D005243:Feces / Q000382:microbiology; D005260:Female; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D005705:Gallbladder Diseases / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use*; D012480:Salmonella Infections; D012485:Salmonella typhi / Q000302:isolation & purification; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014435:Typhoid Fever; D014556:Urine / Q000382:microbiology
D005493:Folic Acid Antagonists; D011743:Pyrimidines; D013420:Sulfamethoxazole