Antitumor activity in mice of tentacles of 2 tropical sea annelids.
Crude extracts of tentacles of two polychaetous annelids completely inhibit growth of Erlich ascites tumor in 60 to 100 percent of treated mice. Dialyzed extracts of one of these annelids, Lanice conchilega, show activity in the retentate after pronase digestion, suggesting that antitumor activity is associated with a nonprotein component of the crude tentacle extract.
D000818:Animals; D000845:Annelida; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D001681:Biological Assay; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D003956:Dialysis; D005260:Female; D006254:Hawaii; D008386:Marine Biology; D051379:Mice; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology; D014020:Tissue Extracts / Q000627:therapeutic use* / Q000633:toxicity
D000970:Antineoplastic Agents; D014020:Tissue Extracts