Maximal acid response of Pavlov pouches to food and histamine.
Secretion of gastric acid in response to histamine, insulin, and a meal of liver, with and without 5% bone dust, was studied in three dogs with Pavlov pouches and gastric fistulas. The ratios of insulin-induced to histamine-induced secretion were the same in pouch and main stomach indicating that their innervation was equivalent. Meals of a liver and bone dust mixture in amounts of 11 to 44 g/kg resulted in Pavlov pouch acid outputs that were 34 to 56% higher than the maximal response to histamine (p < 0.05 to < 0.001). Liver without bone dust also produced higher acid outputs than histamine. These results indicate that combinations of endogenously generated stimuli can produce a potentiated gastric response which exceeds that produced by histamine alone.
D000818:Animals; D004285:Dogs; D005502:Food; D005747:Gastric Fistula; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D013268:Stimulation, Chemical; D013270:Stomach / Q000294:innervation; D014630:Vagus Nerve / Q000502:physiology
D007328:Insulin; D006632:Histamine