Acetylcholine sensitivity of muscle fiber membranes: mechanism of regulation by motoneurons.
Inhibitors of RNA and protein synthesis prevent the development of acetylcholine supersensitivity in organ-cultured rat diaphragm muscle but do not affect established acetylcholine sensitivity. The restriction of this sensitivity in innervated muscle apparently involves muscle fibers.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003864:Depression, Chemical; D003964:Diaphragm; D005260:Female; D005809:Genes, Regulator; D007930:Leucine / Q000378:metabolism; D008564:Membrane Potentials; D009046:Motor Neurons / Q000502:physiology*; D009124:Muscle Proteins / Q000096:biosynthesis; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D009924:Organ Culture Techniques; D010791:Phrenic Nerve; D011691:Puromycin / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D009124:Muscle Proteins; D014316:Tritium; D003609:Dactinomycin; D011691:Puromycin; D012313:RNA; D003513:Cycloheximide; D007930:Leucine; D000109:Acetylcholine; D014529:Uridine