Quinacrine: mechanisms of antimalarial action.
Two new interesting modes of action of quinacrine have been discovered. The first concerns a dose-related inhibition of uptake of [8-(3)H] adenosine into host cells of parasitized blood. Second, the drug inhibits the incorporation of tritiated adenosine triphosphate primarily into RNA but also into DNA of the erythrocyte-free malarial parasite Plasmodium berghei.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology; D008288:Malaria / Q000188:drug therapy; D009705:Nucleosides / Q000378:metabolism; D010961:Plasmodium / Q000187:drug effects / Q000378:metabolism*; D011796:Quinacrine / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014316:Tritium
D009705:Nucleosides; D014316:Tritium; D012313:RNA; D000255:Adenosine Triphosphate; D004247:DNA; D011796:Quinacrine