Dimethylbenzanthracene tumorigenesis and aryl hydrocarbon hydroxylase in mouse skin: inhibition by 7,8-benzoflavone.
Mouse skin contains aryl hydrocarbon hydroxylase which is highly inducible. The enzyme system is inhibited when 7,8-benzoflavone is added to homogenates of skin epidermis. 7,8-Benzoflavone also inhibits mouse skin tumorigenesis caused by repeated treatment with 9,10-dimethylbenzanthracene or by a single treatment with this chemical followed by weekly treatment with croton oil. These findings suggest that this enzyme system may be responsible for the activation of 9,10-dimethylbenzanthracene to its carcinogenic form.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D002471:Cell Transformation, Neoplastic; D003436:Croton Oil; D005419:Flavonoids / Q000494:pharmacology*; D051379:Mice; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D009281:Naphthalenes / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012867:Skin / Q000201:enzymology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000188:drug therapy
D001551:Benz(a)Anthracenes; D005419:Flavonoids; D009281:Naphthalenes; D003436:Croton Oil; D006899:Mixed Function Oxygenases