Mediation of immunity to tumor isografts in mice by heterologous ribonucleic acid.
The growth of tumor isografts in inbred mice is inhibited by intra-peritoneal injections of syngeneic spleen incubated, in vitro, with ribonucleic acid extracted from guinea pigs immunized with the same mouse tumor. This inhibition is partially tumor-specific. Treatment with ribonuclease abolishes the response.
D000818:Animals; D006168:Guinea Pigs; D051379:Mice; D009368:Neoplasm Transplantation; D012313:RNA / Q000494:pharmacology*; D012260:Ribonucleases / Q000494:pharmacology; D013154:Spleen / Q000637:transplantation; D014181:Transplantation Immunology / Q000187:drug effects*; D014184:Transplantation, Homologous
D012313:RNA; D012260:Ribonucleases