Hemoglobin interaction: modification of solid phase composition in the sickling phenomenon.
Direct analyses of solid phase formed by deoxygenating solutions of sickle-cell hemoglobin (Hb S) in the presence of certain other hemoglobin species show that hemoglobins A and C can participate in the filamentous fine structure characteristic of the sickling phenomenon. In contrast, fetal hemoglobin (Hb F) is nearly completely excluded.
D000755:Anemia, Sickle Cell / Q000097:blood*; D001809:Blood Viscosity; D002474:Cell-Free System; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004912:Erythrocytes / Q000166:cytology; D005319:Fetal Hemoglobin / Q000032:analysis; D006444:Hemoglobin C / Q000032:analysis; D006445:Hemoglobin C Disease / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006801:Humans; D008854:Microscopy, Electron; D010100:Oxygen; D010455:Peptides / Q000032:analysis
D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D010455:Peptides; D006444:Hemoglobin C; D005319:Fetal Hemoglobin; D010100:Oxygen