Comparison of effect of salbutamol and isoprenaline on spirometry and blood-gas tensions in bronchial asthma.
The effect of the aerosol inhalation of 200 mug. of salbutamol and 1,000 mug. of isoprenaline on spirometry and blood-gas tensions was compared in the same 11 asthmatic subjects. Both drugs significantly reduced airway obstruction, and the extent of the reduction did not differ for periods of up to 30 minutes. After isoprenaline tachycardia and a small significant fall in arterial oxygen tension occurred, whereas after salbutamol there was no change in pulse rate and the arterial oxygen tension did not fall.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000097:blood; D000431:Ethanol / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D013147:Spirometry
D001993:Bronchodilator Agents; D002245:Carbon Dioxide; D000431:Ethanol; D007545:Isoproterenol; D010100:Oxygen