Reactions of alpha methylene lactone tumor inhibitors with model biological nucelophiles.
Thiols are the most reactive nucleophilic reagents among the biological models investigated. They undergo "Michael-type" addition to the polyfunctional sesquiterpene lactones. The rapid rates of reaction with L-cysteine were measured and the reaction products were characterized. Each addition of thiol successively decreased the cytotoxicity of the adducts formed.
D000970:Antineoplastic Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D003545:Cysteine; D007783:Lactones; D010937:Plant Growth Regulators; D013053:Spectrophotometry; D013729:Terpenes
D000970:Antineoplastic Agents; D007783:Lactones; D010937:Plant Growth Regulators; D013729:Terpenes; D003545:Cysteine