Alcohol aversion in the rat: behavioral assessment of noxious drug effects.
Injections of p-chlorophenylalanine or n-butyraldoxime given after rats were first given a 10-minute drinking test with saccharin or ethanol solutions produced a learned aversion to these solutions. These findings suggest that the reduced self-selection of alcohol (preference) resulting from the administration of these drugs, reported by others, is not specifically alcohol-related. The technique described offers a sensitive procedure for the assessment of unpleasant effects of drugs.
D000427:Alcohol Deterrents / Q000494:pharmacology*; D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D002087:Butyrates / Q000494:pharmacology; D002713:Chlorine / Q000494:pharmacology; D004336:Drug Antagonism; D010091:Oximes / Q000494:pharmacology; D010649:Phenylalanine / Q000494:pharmacology; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology*
D000427:Alcohol Deterrents; D002087:Butyrates; D010091:Oximes; D013549:Sweetening Agents; D010649:Phenylalanine; D002713:Chlorine; D012439:Saccharin