L-dihydroxyphenylalanine: effect on S-adenosylmethionine in brain.
Forty-five minutes after intraperitoneal injection of a single dose (100 milligrams per kilogram) of L-dihydroxyphenylalanine, the concentration of S-adenosylmethionine in rat brain was lowered by 76 percent. As little as 10 milligrams of L-dihydroxyphenylalanine per kilogram decreased content of S-adenosylmethionine in the adrenal medulla by 51 percent, whereas 100 milligrams per kilogram did not significantly depress concentration of S-adenosylmethionine in the liver in this time interval. Concentration of S-adenosylmethionine in the brain varied diurnally; L-dihydroxyphenylalanine lowered this concentration whether administered at the daily peak or at the nadir.
D000313:Adrenal Medulla / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002940:Circadian Rhythm; D003864:Depression, Chemical; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000378:metabolism*; D008745:Methylation; D009638:Norepinephrine / Q000378:metabolism; D009705:Nucleosides / Q000378:metabolism*; D051381:Rats; D013237:Stereoisomerism
D009705:Nucleosides; D004295:Dihydroxyphenylalanine; D008715:Methionine; D004298:Dopamine; D009638:Norepinephrine