Colcemid sensitivity of fission yeast and the isolation of colcemid-resistant mutants.
Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N-methylcolchicine) in nutrient medium. Cell growth continiues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.
D002455:Cell Division / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D009154:Mutation; D012440:Saccharomyces / Q000187:drug effects* / Q000254:growth & development
D003078:Colchicine