The growth characteristics of an ascitic plasmacytoma (MP 5563) terminating by fistulous communication with the blood-stream.
The growth of ascitic mouse plasmacytoma 5563 has been monitored by (51)Cr-RBC dilutions within the peritoneal cavity together with differential cell counts and protein measurements.Following the intraperitoneal transplantation of one million tumour cells, there is a latency period of 4 days, possibly explained as only a 5% survival of the inoculum. This is followed by logarithmic growth from 4 to 8 days with a doubling time of 18 hours, always similar in different animals. Eventually after 8 days and after about 100 million cells an asymptote is reached which is due to a fistula-like communication between blood-stream and peritoneal cavity. This terminal phase (9-10 days) is rapidly followed by death of the mouse.Reliable tumour cell counts can only be achieved between 4 and 8 days.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002452:Cell Count; D002455:Cell Division; D002859:Chromium Isotopes; D004912:Erythrocytes; D005402:Fistula / Q000503:physiopathology; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000503:physiopathology; D010529:Peritoneal Cavity / Q000503:physiopathology; D010954:Plasmacytoma / Q000503:physiopathology
D002859:Chromium Isotopes