Free and protein-bound glutathione in normal and cataractous human lenses.
Protein-bound glutathione was identified and measured in normal and cataractous human lenses. In a major group of cataracto us lenses the bound glutathione concentration was higher than normal. Study of normal lenses showed that their glutathione content is age-dependent, decreasing steadily from about 3.5mumol/g of lens at age 20 years to about 1.8mumol/g of lens at age 65 years. Cataract brings further decreases.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002386:Cataract / Q000378:metabolism*; D002648:Child; D004586:Electrophoresis; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D007908:Lens, Crystalline / Q000032:analysis*; D008875:Middle Aged; D011485:Protein Binding
D005978:Glutathione