Permeability of the small intestine to substances of different molecular weight.
The permeability of the rabbit small intestine has been studied by measuring the plasma clearances of water-soluble molecules over the molecular weight range 60-33,000. An inverse relationship has been demonstrated between permeability and molecular weight. The significance of these findings in relation to current concepts of the ;pore hypotheses' is discussed, and the possible physiological and pathological implications are considered.
D000818:Animals; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D005632:Fructose / Q000097:blood / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D007444:Inulin / Q000097:blood / Q000378:metabolism; D008970:Molecular Weight; D010539:Permeability; D011205:Povidone / Q000097:blood / Q000378:metabolism; D011817:Rabbits; D014508:Urea / Q000097:blood / Q000378:metabolism; D014805:Vitamin B 12 / Q000097:blood / Q000378:metabolism
D005632:Fructose; D014508:Urea; D007444:Inulin; D003404:Creatinine; D011205:Povidone; D014805:Vitamin B 12