Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the hydrogen-bonded structure of ribonucleic acid of brain-cortex ribosomes.
1. The action of mescaline sulphate on the hydrogen-bonded structure of the RNA constituent of ribosomes of goat brain-cortex slices was studied by using the hyperchromic effect of heating and formaldehyde reaction. 2. The ribosomal total RNA species of the mescaline-treated brain-cortex slices have a smaller proportion of hydrogen-bonded structure than the ribosomal RNA species of the untreated brain-cortex slices. 3. Mescaline also appears to have affected this lowering of hydrogen-bonded structure of the ribosomal 28S RNA of brain-cortex tissue.
D000818:Animals; D001665:Binding Sites; D002499:Centrifugation, Density Gradient; D002540:Cerebral Cortex / Q000187:drug effects*; D005557:Formaldehyde; D006041:Goats; D006358:Hot Temperature; D066298:In Vitro Techniques; D008635:Mescaline / Q000494:pharmacology*; D012313:RNA / Q000032:analysis*; D012270:Ribosomes / Q000032:analysis / Q000187:drug effects*
D005557:Formaldehyde; D012313:RNA; D008635:Mescaline