The effect of oral contraceptive steroids on bile secretion and bilirubin Tm in rats.
1. The effect of oestrogens and progestogens and their 17alpha-ethinyl derivatives on bile flow, maximum rate of bilirubin secretion, serum and liver bilirubin has been studied.2. Both 17alpha-ethinyl substituted oestrogens and progestogens greatly reduced the basal bile flow. The parent compounds, oestradiol-17beta and 19-nortestosterone had little or no effect.3. A much larger dose of progestogens (40 mg/kg) than oestrogens (5 mg/kg) was needed.4. Between 12 and 48 h were required for 17alpha-ethinyloestradiol to produce the effect.5. Bilirubin maximum secretion rate (Tm) was little affected, the only significant reduction being produced by the 3-methyl ether of 17alpha-ethinyloestradiol (mestranol).6. Rises in serum conjugated bilirubin following infusion of bilirubin were produced by 17alpha-ethinyloestradiol and mestranol but not by the progestogens.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood / Q000378:metabolism*; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003864:Depression, Chemical; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000032:analysis; D008656:Mestranol / Q000494:pharmacology; D009277:Nandrolone / Q000494:pharmacology; D011372:Progestins / Q000494:pharmacology*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D003276:Contraceptives, Oral; D004967:Estrogens; D011372:Progestins; D004997:Ethinyl Estradiol; D004958:Estradiol; D009277:Nandrolone; D008656:Mestranol; D001663:Bilirubin