Measurement of plasma digoxin concentration by radioimmunoassay.
A rapid, sensitive, and precise method for measuring the plasma digoxin concentration has been developed with the radioimmunoassay technique. Seventy patients receiving digoxin were shown to have plasma digoxin concentrations between 0.4 and 5 ng./ml. Preliminary studies show that though there is a positive correlation between total daily dose and the plasma digoxin concentration, the relationship is not close, and a relatively wide range of plasma digoxin concentrations appear to be consistent with effective digitalization.
D000818:Animals; D000941:Antigens; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D008722:Methods; D011817:Rabbits; D011863:Radioimmunoassay; D011874:Radiometry; D014316:Tritium
D000941:Antigens; D014316:Tritium; D004077:Digoxin