The effect of cardiac disease on hemoglobin-oxygen binding.
The relation between degree of cardiac functional impairment and changes in hemoglobin-oxygen affinity and 2,3-diphosphoglycerate (2,3-DPG) has been studied in 39 patients with noncyanotic heart disease. A progressive decline in hemoglobin-oxygen affinity was found with worsening cardiac function as assessed by cardiac index, arteriovenous oxygen (A-V O(2)) difference, and cardiac symptoms; this alteration in hemoglobin-oxygen binding represents a significant mechanism for adaptation to the limited oxygen supply imposed by the cardiac lesion. The highly significant correlation of mixed venous blood oxygen saturation (S[unk]V(VO2)) with 2,3-DPG and the position of the oxygen dissociation curve suggests that the level of deoxygenated hemoglobin is an important in vivo regulator of hemoglobin-oxygen affinity.
D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000368:Aged; D001665:Binding Sites; D006328:Cardiac Catheterization; D002302:Cardiac Output; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005994:Glycerophosphates / Q000097:blood; D006321:Heart / Q000503:physiopathology*; D006331:Heart Diseases / Q000097:blood* / Q000503:physiopathology; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption
D005994:Glycerophosphates; D006454:Hemoglobins; D000255:Adenosine Triphosphate; D010100:Oxygen