Isolation of leucogenenol from bovine and human liver.
A compound has been isolated from both bovine and human liver that on intravenous or intraperitoneal injection into animals induces in 4-12h an increase in the number of peripheral neutrophils, and in 12-24h an increase in the number of peripheral lymphocytes. At 24h after injection there is also a two- to three-fold increase in the relative number of myeloblasts in the bone marrow. The procedure for isolation and the physical and chemical properties identify the compound as leucogenenol, isolated from the metabolic products of Penicillium gilmanii by Rice (1966).
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002417:Cattle; D002845:Chromatography; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007958:Leukocyte Count; D007964:Leukocytosis / Q000139:chemically induced*; D008099:Liver / Q000032:analysis*; D008110:Liver Extracts; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D009504:Neutrophils / Q000187:drug effects*; D010407:Penicillium / Q000378:metabolism; D011817:Rabbits; D013057:Spectrum Analysis
D008110:Liver Extracts