Synaptic potentials recorded in cell cultures of nerve and muscle.
Initially dissociated spinal cord and muscle cells derived from chick embryos differentiate sufficiently in tissue culture to form functional synaptic contacts. Spontaneous and evoked potentials recorded with intracellular microelectrodes resemble synaptic responses of adult spinal cord and neuromuscular junctions.
D000200:Action Potentials; D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo; D046508:Culture Techniques; D008564:Membrane Potentials; D009132:Muscles / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D013569:Synapses / Q000502:physiology*