Aspirin: intestinal damage in rats.
Lesions induced by aspirin in the small intestine of the rat were visualized after 4 hours by the intravenous administration of a 5 percent solution of pontamine sky blue, 6 BX dye. Dose-response curves in fasted and fed rats indicated that the fed rat was about eight times more susceptible to aspirin-induced intestinal damage than was the fasted rat, while the fasted rat was about 13 times more susceptible to aspirin-induced gastric damage than was the fed rat.
D000818:Animals; D001241:Aspirin; D001391:Azo Compounds; D005508:Food Deprivation; D007082:Ileum; D007410:Intestinal Diseases / Q000139:chemically induced*; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects*; D007583:Jejunum; D008297:Male; D009281:Naphthalenes; D009336:Necrosis; D051381:Rats; D013451:Sulfonic Acids
D001391:Azo Compounds; D009281:Naphthalenes; D013451:Sulfonic Acids; D001241:Aspirin