Simple method for determining isoniazid acetylator phenotype.
Methods have been developed for estimating acetylisoniazid and isoniazid in urine without a spectrophotometer. In experiments with volunteers the ratio of acetylisoniazid to isoniazid in urine samples collected the morning after three spaced oral doses each of 100 mg. was bimodally distributed.
D000085:Acetates / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine; D000284:Administration, Oral; D003124:Colorimetry; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine*; D008722:Methods; D010641:Phenotype
D000085:Acetates; D007538:Isoniazid