Occurrence of epithelial atypia in 51 Indian villagers with oral submucous fibrosis.
Fifty-three biopsies from the oral mucosa in 51 Indian villagers with oral submucous fibrosis have been studied for epithelial changes. A marked atrophy of the epithelium was found in 71.7%; the atrophic epithelium showed no rete ridges. The normally unkeratinized buccal mucosa revealed either ortho- or parakeratosis or hyperortho- or hyperparakeratosis in 48.0%. In one patient the histologic examination disclosed a squamous cell carcinoma. In 22.6% an epithelial atypia was found. The histologic features in these atypias are compared with those seen in leukoplakias from the same survey. The possible precancerous nature of submucous fibrosis is discussed.
D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007194:India; D007642:Keratosis / Q000473:pathology; D008297:Male; D009059:Mouth Diseases / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology*; D009914:Oral Submucous Fibrosis / Q000473:pathology; D011230:Precancerous Conditions