Cephaloridine serum levels in patients on maintenance haemodialysis.
Cephaloridine serum half-life was determined in 11 patients undergoing maintenance haemodialysis. Three of them were anephric. The mean cephaloridine half-life was 10.4 hours. There was an inverse correlation between cephaloridine half-life and the duration of maintenance haemodialysis treatment. Reasons for this are discussed.The effect of haemodialysis with the Kiil dialyser on cephaloridine half-life was studied in three patients.Dosage recommendations for patients on maintenance haemodialysis are suggested.
D000293:Adolescent; D000328:Adult; D002509:Cephaloridine / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008657:Metabolic Clearance Rate; D009392:Nephrectomy; D006435:Renal Dialysis; D013997:Time Factors; D014859:Warfarin / Q000627:therapeutic use
D014859:Warfarin; D003404:Creatinine; D002509:Cephaloridine