Acute effects of a monoamine oxidase inhibitor, tranylcypromine, on thermoregulation in the conscious rabbit.
1. The effect of a single injection of the monoamine oxidase inhibitor, tranylcypromine, administered intravenously (20 mg/kg) or into the lateral cerebral ventricle (5-10 mg), on hypothalamic and rectal temperature, has been investigated.2. Intravenous tranylcypromine causes a significant rise in body temperature, which is due, at least in part, to cutaneous vasoconstriction; this vasoconstriction is augmented by sympathectomy. It is concluded that this vasoconstrictor effect is not mediated via the central nervous system.3. Intraventricular tranylcypromine caused a transient but significant fall in core temperature. This is interpreted as being compatible with selective augmentation of hypothalamic levels of 5-hydroxytryptamine.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002552:Cerebral Ventricles; D003243:Consciousness; D003250:Constriction; D005260:Female; D007031:Hypothalamus / Q000032:analysis; D007267:Injections; D007275:Injections, Intravenous; D011817:Rabbits; D012007:Rectum; D012701:Serotonin / Q000032:analysis; D012867:Skin / Q000098:blood supply; D013562:Sympathectomy; D014191:Tranylcypromine / Q000494:pharmacology*
D012701:Serotonin; D014191:Tranylcypromine