Human glomerular basement membrane: chemical alteration in diabetes mellitus.
The human glomerular basement membrane belongs to the collagen family of proteins. It contains about 7 percent carbohydrate, half of which occurs as glucosylgalactose disaccharide units linked to hydroxylysine. Glomeruli from diabetics contain increased amounts of basement membrane material. In addition, these membranes show a distict chemical alteration c haracterized by a significant decrease in lysine, accoumpanied by an equivalent increase in hydroxylysine and hydroxylysine-linked disaccharide units.
D001485:Basement Membrane / Q000032:analysis*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004187:Disaccharides / Q000032:analysis; D006801:Humans; D007678:Kidney Glomerulus / Q000032:analysis*; D008239:Lysine / Q000032:analysis
D004187:Disaccharides; D008239:Lysine