Metabolite of (-)-trans-delta 8-tetrahydrocannabinol: identification and synthesis.
The major metabolite of (-)-trans-Delta(8)-tetrahydrocannabinol observed in vivo and formed by hepatic microsomes in vitro is 11-hydroxy-trans-Delta(8)-tetrahydrocannabinol. The metabolite was identified spectroscopically and was synthesized from trans-Delta(8)-tetrahydrocannabinol. In tests with rats, the metabolite produced behavioral effects similar to those imparted by Delta(8)- and Delta(9)-tetrahydrocannabinol.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001578:Benzopyrans / Q000032:analysis / Q000138:chemical synthesis / Q000378:metabolism*; D002188:Cannabis; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000378:metabolism; D011817:Rabbits; D051381:Rats
D001578:Benzopyrans