Alcohol oxidation in rate inhibited by pyrazole, oximes, and amides.
Pyrazole, previously reported to inhibit ethanol oxidation in the rat, also effectively blocks the in vivo metabolism of methanol, propanol, isopropanol, n-butanol, and isobutanol. A variety of oximes and amides are also effective inhibitors of ethanol metabolism. These various inhibitors may prove important in the elucidation of several facets of alcohol metabolism and also may have application in the treatment of methanol poisoning and in the reduction of the sequelae of the disulfiram-ethanol reaction syndrome in man.
D000433:1-Propanol / Q000378:metabolism*; D000079:Acetaldehyde / Q000506:poisoning; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors; D000435:Alcoholic Intoxication / Q000188:drug therapy; D000438:Alcohols / Q000378:metabolism*; D000577:Amides / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D002247:Carbon Isotopes; D003864:Depression, Chemical; D000431:Ethanol / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D000432:Methanol / Q000378:metabolism* / Q000506:poisoning; D010091:Oximes / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011720:Pyrazoles / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats
D000438:Alcohols; D000577:Amides; D002247:Carbon Isotopes; D010091:Oximes; D011720:Pyrazoles; D000431:Ethanol; D000433:1-Propanol; D000429:Alcohol Oxidoreductases; D000079:Acetaldehyde; D000432:Methanol