Increased pulmonary arterial pressures after pentazocine in myocardial infarction.
In 15 patients with acute myocardial infarction intravenous pentazocine in a dose of either 30 or 60 mg. was followed by a significant increase in mean pulmonary arterial pressure. In the group receiving the 60-mg. dose this change was associated with a significant increase in systemic arterial pressure, total peripheral resistance, and left ventricular minute work. Because of these circulatory effects intravenous pentazocine in a dose of 60 mg. would seem to be unsuitable for the relief of pain in myocardial infarction.
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy; D010423:Pentazocine / Q000008:administration & dosage / Q000009:adverse effects*; D011651:Pulmonary Artery; D014655:Vascular Resistance / Q000187:drug effects
D010423:Pentazocine