Diabetes in the aged: underdiagnosis and overtreatment.
In keeping with the already known high prevalence of diabetes among residents of the Jewish Home for the Aged, Toronto, annual screening disclosed an average incidence of 25.5% of abnormal glucose tolerance (two-hour post-glucose blood sugars above 140 mg./100 ml.) in residents not known to be diabetic.Forty-five (47%) of the 94 residents with abnormal screening values were considered subsequently to be diabetic according to our criteria.Long-term follow-up, particularly of 81 residents initially normoglycemic in 1964-5, confirmed that the natural course of glucose tolerance in this population was one of progressive deterioration.By contrast, improvement amounting to remission has been demonstrated in nine out of 20 residents several years after they had been declared diabetic, and is thought to have been induced by dietotherapy.Moderate hyperglycemia per se did not cause symptoms in these almost always keto-resistant and usually aglycosuric aged diabetics, who often claimed they felt better when hyperglycemic. Hypoglycemia was an ever present danger when anti-diabetic medication was used; it was the main reason for undertreatment.So far, data from our long-term study have not shown morbidity to be markedly increased in the diabetics, and mortality was found to be evenly distributed among diabetic and non-diabetic male residents. However, in the females there was a clear correlation between mortality rate and the diminished glucose tolerance.What may appear as overdiagnosis of diabetes in the aged is recommended in the hope that early institution of dietary treatment will delay the development of clinical diabetes and the need for anti-diabetic agents. This, in turn, would prevent iatrogenic hypoglycemia. It would also reduce the severity and frequency of spontaneous hypoglycemia which, we believe, occurs more commonly in the early phase of diabetes in the aged than is generally realized.
D000367:Age Factors; D000368:Aged; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000628:therapy*; D004035:Diet Therapy; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006707:Homes for the Aged; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis; D007003:Hypoglycemia / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000009:adverse effects; D007585:Jews; D008297:Male; D008403:Mass Screening; D009765:Obesity; D011236:Prediabetic State / Q000175:diagnosis / Q000628:therapy; D012737:Sex Factors; D013997:Time Factors
D007004:Hypoglycemic Agents