Chemically induced porphyria: prevention by prior treatment with phenobarbital.
The excessive induction of hepatic delta-aminolevulinic acid synthetase in rats after the administration of porphyria-inducing compounds is prevented by prior treatment with phenobarbital. Studies in vivo and in vitro indicate that phenobarbital prevents the induction of chemical porphyria by increasing the rate of detoxification of inducers by way of drug-metabolizing enzymes of the hepatic endoplasmic reticulum.
D000217:Acyltransferases / Q000096:biosynthesis*; D000577:Amides; D000596:Amino Acids; D000818:Animals; D001711:Biotransformation; D002247:Carbon Isotopes; D002855:Chromatography, Thin Layer; D004721:Endoplasmic Reticulum / Q000201:enzymology*; D004790:Enzyme Induction / Q000187:drug effects*; D005260:Female; D007982:Levulinic Acids / Q000096:biosynthesis; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D008862:Microsomes, Liver / Q000378:metabolism; D010634:Phenobarbital / Q000627:therapeutic use*; D011164:Porphyrias / Q000139:chemically induced* / Q000188:drug therapy*; D011374:Progesterone; D051381:Rats; D013386:Succinates / Q000096:biosynthesis
D000577:Amides; D000596:Amino Acids; D002247:Carbon Isotopes; D007982:Levulinic Acids; D013386:Succinates; D011374:Progesterone; D000217:Acyltransferases; D010634:Phenobarbital