Carbon tetrachloride metabolism in sheep and in Fasciola hepatica.
1. The excretion of carbon tetrachloride and its metabolites in bile and urine were studied.2. Liver flukes in vitro metabolized carbon tetrachloride and hexachloroethane by dechlorination.3. Carbon tetrachloride, liver lipid from rabbits which received carbon tetrachloride and a carbon tetrachloride methyl oleate complex were toxic to liver flukes in vitro, in the presence of sheep bile.4. A direct fasciocidal action of carbon tetrachloride may contribute to the therapeutic effect of the drug.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000378:metabolism* / Q000652:urine; D002725:Chloroform / Q000032:analysis; D002849:Chromatography, Gas; D005210:Fasciola hepatica / Q000187:drug effects / Q000378:metabolism*; D006846:Hydrocarbons, Halogenated / Q000032:analysis; D008099:Liver / Q000032:analysis; D010635:Phenolphthaleins / Q000378:metabolism; D011817:Rabbits; D012756:Sheep
D006846:Hydrocarbons, Halogenated; D010635:Phenolphthaleins; D002725:Chloroform; D002251:Carbon Tetrachloride