Cyclophosphamide therapy of idiopathic nephrosis.
Thirty-three children with steroid-dependent or steroid-resistant idiopathic nephrosis were treated with a combination of cyclophosphamide and prednisone. Remission occurred in all 23 steroid-dependent patients and, at last report, 12 had gone without any medication for periods of from two months to 21 months without relapse. Remission occurred in five of ten steroid-resistant patients. The renal biopsy findings in these patients demonstrate a correlation between the "minimal change" lesion and a positive response to cyclophosphamide.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D009401:Nephrosis / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*; D019966:Substance-Related Disorders
D003520:Cyclophosphamide; D011241:Prednisone