Histamine production by transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis.
A transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis contained appreciable amounts of histamine. Dialyzed, microsome-free supernatant of tumor tissue produced definite amounts of histamine in the presence of L-histidine and pyridoxal phosphate. These findings may relate to hypersecretion of gastric acid and formation of multiple ulcers in the stomach and duodenum of Mastomys bearing carcinoids.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism; D002276:Carcinoid Tumor / Q000378:metabolism* / Q000662:veterinary*; D002471:Cell Transformation, Neoplastic; D004381:Duodenal Ulcer / Q000209:etiology; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000201:enzymology / Q000503:physiopathology; D006632:Histamine / Q000032:analysis / Q000096:biosynthesis*; D006639:Histidine / Q000378:metabolism; D009368:Neoplasm Transplantation; D011732:Pyridoxal Phosphate / Q000378:metabolism; D012376:Rodent Diseases / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000662:veterinary*; D013276:Stomach Ulcer / Q000209:etiology
D006639:Histidine; D011732:Pyridoxal Phosphate; D006632:Histamine; D002262:Carboxy-Lyases