The role of phosphate in the secretion of parathyroid hormone in man.
In man, oral administration of 1 g of phosphorus resulted in a 60-125% increase in serum immunoassayable parathyroid hormone (PTH) concentration. Peak PTH levels were attained in 1 hr, and PTH returned to base line levels in 2 hr. This increase in PTH appeared to be initiated by a very small decrease of total and ionized calcium and was abolished by a calcium infusion. There was no correlation between serum phosphorus and PTH. The experiments show that oral phosphorus administration initiates a calcium-mediated control system for PTH secretion and that this system operates very sensitively in man.
D000328:Adult; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D010710:Phosphates / Q000008:administration & dosage / Q000502:physiology*; D010758:Phosphorus / Q000097:blood; D011863:Radioimmunoassay; D013997:Time Factors
D010281:Parathyroid Hormone; D010710:Phosphates; D010758:Phosphorus; D002118:Calcium