Product inhibition of the fermentative formation of glutamic acid.
The addition of penicillin to cells of Corynebacterium glutamicum growing in 5-liter fermentors initiated the excretion of glutamic acid. The rate of glutamate production in fermentors declined continuously with time and reached 75% of the initial rate in 24 hr after penicillin had been added. The addition of glutamate to resting cell suspensions had only a slight effect on sugar utilization but caused a marked decrease in glutamate excretion. It is suggested that the high level of glutamate accumulating in the fermentation broth is responsible for inhibiting its own production.
D003352:Corynebacterium / Q000254:growth & development / Q000378:metabolism*; D003864:Depression, Chemical; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000096:biosynthesis* / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D013997:Time Factors
D005971:Glutamates; D005947:Glucose; D010400:Penicillin G