Fetal kidney in organ culture: abnormalities of development induced by decreased amounts of potassium.
Kidneys from fetal mice (10 to 18 days' gestation) were grown in organ culture. Concentrations of potassium less than 9 milliequivalents per liter (10- to 14-day kidneys), and less than 6 milliequivalents per liter (14- to 18-day kidneys), produced abnormal branching, failure of nephron induction, and occasional cystic dilatations of the ureteral bud. These studies emphasize the importance of an environment with a high concentration of potassium for development of the fetal kidney.
D000818:Animals; D003470:Culture Media; D046508:Culture Techniques; D005260:Female; D005333:Fetus; D007008:Hypokalemia / Q000150:complications; D007668:Kidney / Q000002:abnormalities* / Q000196:embryology*; D051379:Mice; D009924:Organ Culture Techniques; D009994:Osmolar Concentration; D011188:Potassium / Q000502:physiology*; D011247:Pregnancy
D003470:Culture Media; D011188:Potassium