Alkaloids from catecholamines in adrenal tissue: possible role in alcoholism.
Epinephrine and norepinephrine condensed with acetaldehyde or with formaldehyde in dilute aqueous solution at neutral pH and room temperature to form 1,2,3,4-tetrahydroiso-quinoline alkaloids. Similar condensation reactions occurred in cow adrenal glands perfused with dilute aldehyde solutions at 37 degrees C. Biosynthesis of these alkaloids in vivo could play a role in altering an individual's behavior during and after the ingestion of alcohol.
D000079:Acetaldehyde / Q000378:metabolism*; D000311:Adrenal Glands / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism*; D000470:Alkaloids / Q000096:biosynthesis* / Q000138:chemical synthesis; D000818:Animals; D002417:Cattle; D002855:Chromatography, Thin Layer; D004837:Epinephrine / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000096:biosynthesis* / Q000138:chemical synthesis; D009638:Norepinephrine / Q000378:metabolism*; D010477:Perfusion; D012996:Solutions
D000470:Alkaloids; D007546:Isoquinolines; D012996:Solutions; D000079:Acetaldehyde; D009638:Norepinephrine; D004837:Epinephrine