Sensitivity of Nocardia to trimethoprim and sulphonamides in vitro.
Studies in vitro of the sensitivity to trimethoprim and sulphonamides of nine strains of N. asteroides, two strains of N. caviae, and one of N. blackwellii are presented. No unequivocal evidence of synergism was found. Despite this, the inclusion of trimethoprim in the drug regime when sulphonamides are used in the treatment of nocardiosis is suggested on empirical grounds.
D005493:Folic Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects*; D009617:Nocardia Infections / Q000188:drug therapy; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D013411:Sulfadiazine / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*
D005493:Folic Acid Antagonists; D011743:Pyrimidines; D013449:Sulfonamides; D013411:Sulfadiazine; D013420:Sulfamethoxazole