Immunoglobulin M heavy chain disease: intracellular origin of the mu chain fragment.
Cells obtained from a patient with mu heavy chain disease synthesize a mu heavy chain fragment with a molecular weight of 55,000. The fragment is detected intracellularly after short labeling times and then is assembled inside the cell and secreted as a disulfide-linked polymer.
D000921:Antibody-Producing Cells / Q000378:metabolism; D001797:Blood Protein Electrophoresis; D002247:Carbon Isotopes; D004589:Electrophoresis, Disc; D006362:Heavy Chain Disease / Q000378:metabolism*; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007136:Immunoglobulins / Q000096:biosynthesis; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000378:metabolism; D008967:Molecular Biology; D010452:Peptide Biosynthesis; D010455:Peptides / Q000378:metabolism; D013912:Threonine / Q000378:metabolism; D014633:Valine / Q000378:metabolism
D002247:Carbon Isotopes; D007075:Immunoglobulin M; D007136:Immunoglobulins; D010455:Peptides; D013912:Threonine; D007930:Leucine; D014633:Valine