Interference of iron with the absorption of tetracyclines in man.
Ferrous sulphate administered together with tetracycline and three of its derivatives-oxytetracycline, methacycline, and doxycycline-was found seriously to impair the absorption of these antibiotics. Thus even small doses of iron taken simultaneously should be avoided during tetracycline treatment.
D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D008690:Methacycline / Q000097:blood / Q000378:metabolism; D010118:Oxytetracycline / Q000097:blood / Q000378:metabolism; D013752:Tetracycline / Q000097:blood / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D007501:Iron; D013752:Tetracycline; D008690:Methacycline; D010118:Oxytetracycline