Protection from the embryopathic effects of 7-hydroxymethyl-12-methylbenz(a)anthracene by 2-methyl-1,2-bis-(3-pyridyl)1-propanone(metopirone, Ciba) and beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A).
Pretreatment with Metopirone (40 mg.) or SKF 525-A (2 mg./100 g. maternal body weight) protected aganist the embryotoxic and teratogenic actions of7-OHM-12-MBA) (2.5 mg/100 g. maternal body weight) in the Sprague-Dawley rat. At the doses administered SKF-525-A was a more efficient protector than Metopirone. The adrenocorticolytic actions of 7-OHM-12-MBA in the maternal adrenal glands were also prevented by these compounds and a close correlation existed between the degree of protection of the maternal adrenals and of the foetuses. It is suggested that the ultimate embryopathic substance is a metabolite of 7-OHM-12-MBA.
D000014:Abnormalities, Drug-Induced; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D008797:Metyrapone / Q000494:pharmacology*; D009929:Organ Size; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D011335:Proadifen / Q000494:pharmacology*; D051381:Rats
D001551:Benz(a)Anthracenes; D011335:Proadifen; D008797:Metyrapone