Fluorocitrate inhibition of aconitase: relative configuration of inhibitory isomer by x-ray crystallography.
The fluorocitrate isomer that is a strong inhibitor and inactivator of aconitase has been shown by x-ray crystallographic studies on the rubidium ammonium salt to have the configurations (1R : 2R) or (1S : 2S) 1-fluoro-2-hydroxy-1,2,3-propanetricarboxylic acid. A possible mechanism for the action of fluorocitrate is proposed which involves the 1R : 2R isomer suggested from biochemical data.
D002951:Citrates / Q000494:pharmacology*; D005461:Fluorine / Q000494:pharmacology*; D005463:Fluoroacetates / Q000494:pharmacology; D006836:Hydro-Lyases / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D002951:Citrates; D005463:Fluoroacetates; D005461:Fluorine; D006836:Hydro-Lyases