Irreversible enzyme inhibitors. CLXXVI. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine by ether bridging to a terminal sulfonyl fluoride.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000201:enzymology; D004987:Ethers; D005459:Fluorides; D005493:Folic Acid Antagonists; D007680:Kidney Neoplasms / Q000201:enzymology; D007939:Leukemia L1210 / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms / Q000201:enzymology; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology*; D051381:Rats; D013160:Splenic Neoplasms / Q000201:enzymology; D013450:Sulfones; D013997:Time Factors; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology*
D004987:Ethers; D005493:Folic Acid Antagonists; D013450:Sulfones; D014227:Triazines; D005459:Fluorides