Thermal damage to red cells.
Erythrocytes from a burned patient show a temporal sequence of morphological changes. Immediate severe changes occur which are followed by a transient phase only of less abnormal morphology. Heating whole blood in vitro to 49 degrees C instead of 50 degrees C does not show the expected dose response curve. Heating whole blood in vitro to 50 degrees C induces progressive morphological changes. Fractionation of whole blood and subsequent heating to 48 degrees C show the older cells to be less deformable.
D002056:Burns / Q000097:blood* / Q000503:physiopathology; D002675:Child, Preschool; D004912:Erythrocytes / Q000503:physiopathology*; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning