Development of vascular lesions in insulin-treated animals fed a normal diet.
Experiments were undertaken to study the role of hyperinsulinism in the pathogenesis of atheroma. Chickens injected with long-acting insulin for 19 weeks developed lipid containing lesions in their aortas. This provides further evidence in favour of the hypothesis that insulin and atheroma are causally related.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D002645:Chickens; D006946:Hyperinsulinism / Q000139:chemically induced / Q000150:complications*; D007328:Insulin / Q000008:administration & dosage
D007328:Insulin