Detoxications in peripatus. Sulphate, phosphate and histidine conjugations.
Phenols were detoxified in the Onycophoran Peripatoides novaezealandiae by conjugation with sulphuric acid and phosphoric acid, but no evidence for a glycoside detoxication could be found. [(14)C]Benzoic acid was metabolized in 24h to N(2)-benzoyl-l-histidine, which was identified by electrophoresis, chromatography and dilution analysis. Similar conjugates were formed with p-aminobenzoic acid and p-nitrobenzoic acid. In longer-duration experiments further unidentified metabolites were formed, two of which appeared to result from the further metabolism of the histidine conjugate.
D062365:Aminobenzoates / Q000378:metabolism; D000818:Animals; D001181:Arthropods / Q000378:metabolism*; D001565:Benzoates / Q000378:metabolism*; D001711:Biotransformation; D002854:Chromatography, Paper; D004586:Electrophoresis; D006639:Histidine / Q000378:metabolism*; D010636:Phenols / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism*
D062365:Aminobenzoates; D001565:Benzoates; D010636:Phenols; D010710:Phosphates; D013431:Sulfates; D006639:Histidine