Shear degradation of fibrinogen in the circulation.
Plasma fibrinogen in vitro suffers a loss in clottability due to shearing. From calculation of the mass average shear to which plasma is subjected in the circulation, it is estimated that the half-life of fibrinogen is 4 days. This is in excellent agreement with reports that the half-life of fibrinogen in the circulatory system is 4 to 5 days. Hence shearing may be the mechanism for fibrinogen degradation in the circulatory system.
D001011:Aorta; D001158:Arteries; D001777:Blood Coagulation; D001783:Blood Flow Velocity; D001809:Blood Viscosity; D002196:Capillaries; D005340:Fibrinogen; D006801:Humans; D066298:In Vitro Techniques; D011651:Pulmonary Artery; D011667:Pulmonary Veins; D013997:Time Factors
D005340:Fibrinogen