A comparison of an effect of different anti-inflammatory drugs on human platelets.
Different doses of aspirin, indomethacin, paracetamol, benorylate, and sodium salicylate were taken by four volunteers. The minimal dose that altered a platelet function test and the persistence of this alteration at different dose levels were studied. Minute doses of indomethacin (0.035 mg/kg) were effective but the effect of even a large single dose did not persist. A tenth of the therapeutic dose of aspirin (1 mg/kg) was effective, and higher doses altered the platelets' function for several days. Benorylate in a high therapeutic dose gave aspirin-like results. Paracetamol and sodium salicylate were relatively inactive. The persistence of the aspirin effect may be related to the acetyl group. These findings are surveyed in relation to a general theory of the action of anti-inflammatory drugs.
D000082:Acetaminophen / Q000494:pharmacology; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010973:Platelet Adhesiveness / Q000187:drug effects; D012459:Salicylates / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D012459:Salicylates; D000082:Acetaminophen; D001241:Aspirin; D007213:Indomethacin; D004837:Epinephrine