Irreversible enzyme inhibitors. CLXXIV. Metabolism of 4-(p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)hydrocinnamido)-o-toluenesulfonyl fluoride (NSC-113423), an active-site-directed irreversible inhibitor of dihydrofolic reductase.
D000818:Animals; D002247:Carbon Isotopes; D002855:Chromatography, Thin Layer; D005243:Feces / Q000032:analysis; D005493:Folic Acid Antagonists; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013450:Sulfones / Q000378:metabolism; D014050:Toluene / Q000378:metabolism; D014227:Triazines / Q000097:blood / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology* / Q000652:urine
D002247:Carbon Isotopes; D005493:Folic Acid Antagonists; D013450:Sulfones; D014227:Triazines; D014050:Toluene