Irreversible enzyme inhibitors. CLXXIX. Active-site-directed irreversible enzyme inhibitors of dihydrofolate reductase from 1-(3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine with oxyamide bridges to a terminal sulfonyl fluoride.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000201:enzymology; D055598:Chemical Phenomena; D002621:Chemistry; D046508:Culture Techniques; D005459:Fluorides / Q000494:pharmacology; D005493:Folic Acid Antagonists; D007939:Leukemia L1210 / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology; D051381:Rats; D013450:Sulfones / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology*
D005493:Folic Acid Antagonists; D013450:Sulfones; D014227:Triazines; D005459:Fluorides