Hyperphenylalaninemia: disaggregation of brain polyribosomes in young rats.
A single injection of l-phenzylalanine in 7-day-old rats produtced disaggregation of brain polyribosomties and inhibition of in vitro protein synthesis in cell-free systems prepared from brain. Liver polyribosomes and in vitro protein synthesis in hepatic systems were not affected. In 4-week-old rats these effects on brain protein synthesis did not occur.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry; D002474:Cell-Free System; D002499:Centrifugation, Density Gradient; D004195:Disease Models, Animal; D006801:Humans; D007274:Injections, Intraperitoneal; D010649:Phenylalanine / Q000494:pharmacology*; D010661:Phenylketonurias / Q000378:metabolism*; D014176:Protein Biosynthesis; D051381:Rats; D012270:Ribosomes / Q000187:drug effects*
D010649:Phenylalanine