Antilymphocyte serum and tissue culture used to investigate role of cell-mediated response in viral encephalitis in mice.
Antilymphocyte serum given to suppress selectively the cell response to Langat virus in Swiss albino mice prolonged the average survival times. In vitro, lymph-node cells from virus-immunized mice were strongly cytotoxic for syngenic non-neuronal brain cells infected with virus. The implications of these findings are discussed, with particular reference to the concept of autoimmunity.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000961:Antilymphocyte Serum; D001102:Arbovirus Infections / Q000276:immunology*; D001327:Autoimmune Diseases; D001921:Brain / Q000166:cytology; D046508:Culture Techniques; D004660:Encephalitis / Q000276:immunology*; D007109:Immunity; D007111:Immunity, Cellular; D007114:Immunization; D008198:Lymph Nodes / Q000166:cytology; D051379:Mice
D000961:Antilymphocyte Serum