Antimalarials: effects on in vivo and in vitro protein synthesis.
The antimalarials quinine, chloroquine, primaquine, and quinacrine inhibited the uptake and incorporation of amino acids in vivo, but these drugs had considerably less effect on cell-free protein synthesis. The results indicate that the primary effect of the four drugs on protein synthesis is blocking of amino acid uptake by the cells.
D000596:Amino Acids / Q000378:metabolism; D000962:Antimalarials / Q000494:pharmacology*; D002247:Carbon Isotopes; D002474:Cell-Free System; D002738:Chloroquine / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D011319:Primaquine / Q000494:pharmacology; D014176:Protein Biosynthesis; D011796:Quinacrine / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D013768:Tetrahymena / Q000187:drug effects*
D000596:Amino Acids; D000962:Antimalarials; D002247:Carbon Isotopes; D002738:Chloroquine; D003513:Cycloheximide; D011803:Quinine; D011796:Quinacrine; D011319:Primaquine