Idiopathic hypercalciuria and hyperparathyroidism.
With provocative tests of parathyroid activity based on phosphate deprivation and the administration of chlorothiazide 8 out of 19 patients with idiopathic hypercalciuria developed hypercalcaemia. Five of the eight underwent exploration of the neck and four of them had parathyroid adenomas; the fifth patient had "normal" glands but responded satisfactorily to subtotal parathyroidectomy. One patient who failed to develop hypercalcaemia had primary chief cell hyperplasia of the parathyroids.
D000236:Adenoma / Q000150:complications / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000535:Aluminum; D002118:Calcium / Q000652:urine*; D002740:Chlorothiazide; D005260:Female; D006801:Humans; D006878:Hydroxides; D006934:Hypercalcemia / Q000139:chemically induced; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000209:etiology; D006965:Hyperplasia / Q000175:diagnosis; D007669:Kidney Calculi / Q000150:complications; D008297:Male; D008875:Middle Aged; D010279:Parathyroid Diseases / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000150:complications / Q000601:surgery; D010710:Phosphates
D006878:Hydroxides; D010710:Phosphates; D002740:Chlorothiazide; D000535:Aluminum; D002118:Calcium