Histocompatibility type and immune responsiveness in random bred Hartley strain guinea pigs.
Outbred Hartley strain guinea pigs capable of responding immunologically to 2,4-dinitrophenylated poly-L-lysine were shown to display a histocompatibility specificity in common with inbred strain 2 guinea pigs. This histocompatibility specificity was not detected in guinea pigs unable to respond immunologically to DNP-PLL. The result suggests that the poly-L-lysine specific immune response gene is very closely linked or even identical with a gene determining a major histocompatibility antigen in guinea pigs.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001947:Breeding; D004140:Dinitrophenols / Q000494:pharmacology; D005796:Genes; D006168:Guinea Pigs; D006648:Histocompatibility; D007106:Immune Sera; D008214:Lymphocytes / Q000276:immunology
D000941:Antigens; D004140:Dinitrophenols; D007106:Immune Sera