title: The role of rubella in the etiology of supravalvular aortic stenosis.
abstract: The possibility of an etiological relationship between rubella embryopathy and sporadic forms of supravalvular aortic stenosis is considered. A case is presented of a patient with rubella embryopathy and supravalvular aortic stenosis associated with pulmonary valvular and peripheral pulmonary artery stenosis, bicuspid aortic valve, aortic valve stenosis and subendothelial myocardial fibrosis. A review of the literature revealed many clinical and pathological features common to both syndromes. The hypothesis that rubella virus produced germ-cell mutation and subsequent persistence of rubella in the zygote produced further fetal damage is presented to explain these observations.
mesh_terms: D001017:Aortic Coarctation / Q000209:etiology*; D001018:Aortic Diseases / Q000151:congenital* / Q000209:etiology; D002386:Cataract / Q000151:congenital / Q000209:etiology; D004719:Endomyocardial Fibrosis / Q000151:congenital / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008850:Microphthalmos / Q000209:etiology; D009154:Mutation; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011666:Pulmonary Valve Stenosis / Q000151:congenital / Q000209:etiology; D012409:Rubella / Q000150:complications / Q000151:congenital*