title: Co-metabolism of methyl- and chloro-substituted catechols by an Achromobacter sp. possessing a new meta-cleaving oxygenase.
abstract: Co-metabolism of 3-methylcatechol, 4-chlorocatechol and 3,5-dichlorocatechol by an Achromobacter sp. was shown to result in the accumulation of 2-hydroxy-3-methylmuconic semialdehyde, 4-chloro-2-hydroxymuconic semialdehyde and 3,5-dichloro-2-hydroxymuconic semialdehyde respectively. Formation of these products indicated that cleavage of the aromatic nucleus of the substituted catechols was accomplished by a new meta-cleaving enzyme, catechol 1,6-oxygenase. This enzyme was equally active on both chloro- and methyl-substituted catechols.
mesh_terms: D000421:Alcaligenes / Q000201:enzymology*; D000447:Aldehydes / Q000096:biosynthesis; D002396:Catechols / Q000378:metabolism*; D010105:Oxygenases / Q000378:metabolism*; D013057:Spectrum Analysis
chemical_list: D000447:Aldehydes; D002396:Catechols; D010105:Oxygenases