Studies of the rat immune response to plasmacytoma 5563 in C3H mice.
Washed lymphocytes from immunized rats showed no reaction against mouse plasmacytoma 5563 in vivo or in vitro.Cell-free lymph from immunized rats was shown to be cytotoxic to the tumour cells in vitro. This effect we have shown to be solely in the 19s fraction after Sephadex G-200 separation.This 19s fraction conferred partial protection to tumour bearing mice when given shortly after transplantation, but had negligible effect against late well established tumour.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000937:Antigen-Antibody Reactions; D002850:Chromatography, Gel; D003165:Complement System Proteins; D003911:Dextrans; D005260:Female; D007114:Immunization; D007075:Immunoglobulin M / Q000032:analysis / Q000627:therapeutic use; D008196:Lymph / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D010954:Plasmacytoma / Q000276:immunology* / Q000628:therapy; D051381:Rats; D013897:Thoracic Duct
D000906:Antibodies; D003911:Dextrans; D007075:Immunoglobulin M; D003165:Complement System Proteins