Norepinephrine metabolism in brainstem of spontaneously hypertensive rats.
Concentrations of norepinephrine in lower brainstem and hypothalamus of genetically hypertensive rats are significantly lower than in control rats. There is a concomitant reduction (50 percent) in aromatic L-amino acid decarboxylase but not in tyrosine hydroxylase activity. A possible relation of this central catecholamine deficiency to the hypertension is discussed.
D000818:Animals; D001794:Blood Pressure; D001933:Brain Stem / Q000201:enzymology / Q000378:metabolism*; D002262:Carboxy-Lyases / Q000378:metabolism; D002395:Catecholamines / Q000502:physiology; D002490:Central Nervous System / Q000502:physiology; D003900:Desoxycorticosterone; D004195:Disease Models, Animal; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D008297:Male; D008638:Mesenteric Arteries / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013687:Telencephalon / Q000201:enzymology; D014443:Tyrosine
D002395:Catecholamines; D003900:Desoxycorticosterone; D014443:Tyrosine; D006899:Mixed Function Oxygenases; D002262:Carboxy-Lyases; D009638:Norepinephrine