Metabolism of methyldecalins.
1. Oral administration of trans- and cis-2-methyldecalin to rabbits increased the urinary glucuronide content. 2. The metabolite of the trans isomer was isolated and shown to be either trans-cis-6- or -7-methyl-2-decalol. The metabolite of the cis isomer was shown to be a 1:1 mixture of cis-6-methyl-2-decalol and cis-7-methyl-2-decalols, but the conformations of the hydroxyl groups were not determined. 3. It was concluded that a specific hydroxylase was responsible for the oxidations observed, and that this hydroxylase could be responsible for the metabolic oxidation of other simple alicyclic compounds.
D000438:Alcohols / Q000652:urine; D000818:Animals; D002845:Chromatography; D005965:Glucuronates / Q000652:urine; D009682:Magnetic Resonance Spectroscopy; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009281:Naphthalenes / Q000378:metabolism* / Q000652:urine; D010084:Oxidation-Reduction; D011817:Rabbits; D013057:Spectrum Analysis; D013237:Stereoisomerism
D000438:Alcohols; D005965:Glucuronates; D009281:Naphthalenes; D006899:Mixed Function Oxygenases