Benzpyrene pretreatment changes the kinetics and pH optimum for aniline hydroxylation in vitro, but not those for benzphetamine demethylation in vitro by rat liver microsomes.
D000814:Aniline Compounds / Q000378:metabolism*; D000818:Animals; D001067:Appetite Depressants / Q000378:metabolism*; D001580:Benzopyrenes / Q000378:metabolism / Q000494:pharmacology*; D001589:Benzphetamine / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009821:Oils / Q000494:pharmacology; D010627:Phenethylamines / Q000378:metabolism*; D011437:Propylamines / Q000378:metabolism*; D051381:Rats; D003313:Zea mays
D000814:Aniline Compounds; D001067:Appetite Depressants; D001580:Benzopyrenes; D009821:Oils; D010627:Phenethylamines; D011437:Propylamines; D001589:Benzphetamine; D006899:Mixed Function Oxygenases