Isolation of 2-amino-1-naphthyl hydrogen sulphate with cetylpyridinium bromide from metabolic and chemical oxidations of 2-naphthylamine.
1. 2-Amino-1-naphthyl hydrogen sulphate can be rapidly isolated from the urine of dogs dosed with 2-naphthylamine by precipitation with cetylpyridinium bromide. 2. No evidence was obtained for the presence of 2-naphthylhydroxylamine-O-sulphonic acid, noteworthy as a possible source of the carcinogens, 2-naphthylhydroxylamine and 2-amino-1-naphthol. 3. Treatment of neutral persulphate oxidations of 2-naphthylamine with the reagent gave only the cetylpyridinium salt of 2-amino-1-naphthyl hydrogen sulphate.
D000588:Amines / Q000652:urine*; D000818:Animals; D002273:Carcinogens
D000588:Amines; D002273:Carcinogens