Metabolism of beta-ionone. Isolation, characterization and identification of the metabolitesin the urine of rabbits.
1. Rabbits dosed orally with beta-ionone excreted in the urine unchanged beta-ionone, 3-oxo-beta-ionone, 3-oxo-beta-ionol, dihydro-3-oxo-beta-ionol and 3-hydroxy-beta-ionol. 2. Excretion products were isolated as 2,4-dinitrophenylhydrazone derivatives (beta-ionone, 3-oxo-beta-ionone, 3-oxo-beta-ionol and dihydro-3-oxo-beta-ionol) and as p-nitrobenzoate derivatives (3-oxo-beta-ionol, dihydro-3-oxo-beta-ionol and 3-hydroxy-beta-ionol), which were characterized and identified by comparison with the synthetic authentic compounds. 3. The glucuronides of 3-oxo-beta-ionol and dihydro-3-oxo-beta-ionol were also detected in the urine. The latter compound was isolated as free glucuronide, sodium salt and 2,4-dinitrophenylhydrazone.
D000438:Alcohols / Q000652:urine; D000818:Animals; D001711:Biotransformation; D002074:Butanones / Q000138:chemical synthesis / Q000378:metabolism / Q000652:urine*; D002855:Chromatography, Thin Layer; D005965:Glucuronates / Q000652:urine; D011817:Rabbits; D013057:Spectrum Analysis; D013729:Terpenes / Q000138:chemical synthesis / Q000378:metabolism / Q000652:urine*
D000438:Alcohols; D002074:Butanones; D005965:Glucuronates; D013729:Terpenes