Radiation-induced fibrosarcoma.
Six cases of fibrosarcoma arising in previously irradiated tissues are reported, out of a total of 220 cases of fibrosarcoma treated at Mount Vernon Hospital during the last 23 years.This rare occurrence may follow at any interval from 3 to 38 years after irradiation, usually after high dosage. Four of our six cases are known to have died of the disease.The literature regarding radiation-induced fibrosarcoma is reviewed and it is suggested that adequate excision or amputation may be curative, if undertaken early enough.
D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D001943:Breast Neoplasms / Q000209:etiology / Q000628:therapy; D005260:Female; D005266:Femoral Neoplasms / Q000209:etiology / Q000532:radiotherapy; D005354:Fibrosarcoma / Q000209:etiology* / Q000601:surgery; D005870:Giant Cell Tumors / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008408:Mastectomy; D009381:Neoplasms, Radiation-Induced; D009918:Orbital Neoplasms / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012175:Retinoblastoma / Q000532:radiotherapy; D014062:Tongue Neoplasms / Q000209:etiology / Q000532:radiotherapy