Pulmonary adenomata induced by carcinogen treatment in organ culture. Influence of increasing amounts of carcinogen.
Explants of lung from 1 month old inbred BALB/c mice were cultured in vitro for 4 days with 3-methylcholanthrene added to the culture medium at various dose levels. They were subsequently implanted subcutaneously into 6-week-old mice of the same strain.Lung adenomata appeared in a high proportion of explants.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D046508:Culture Techniques; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D009924:Organ Culture Techniques; D014184:Transplantation, Homologous
D008748:Methylcholanthrene