Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat. I. Experiments in vivo and with isolated perfused livers.
D000438:Alcohols / Q000096:biosynthesis / Q000097:blood; D000818:Animals; D001593:Benzyl Compounds / Q000096:biosynthesis; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000494:pharmacology; D001658:Biliary Fistula / Q000378:metabolism; D002855:Chromatography, Thin Layer; D003891:Desipramine / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism*; D005965:Glucuronates / Q000096:biosynthesis / Q000097:blood; D007097:Imines / Q000096:biosynthesis; D007099:Imipramine / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007421:Intestine, Small / Q000378:metabolism; D007700:Kinetics; D007813:Laparotomy; D008099:Liver / Q000378:metabolism*; D008297:Male; D010477:Perfusion / Q000295:instrumentation; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000438:Alcohols; D001593:Benzyl Compounds; D001647:Bile Acids and Salts; D005965:Glucuronates; D007097:Imines; D011335:Proadifen; D007099:Imipramine; D003891:Desipramine; D010634:Phenobarbital