Sensitized lymphocytes in muscular dystrophy: evidence for a neural factor in pathogenesis.
Lymphocytes of patients suffering from Duchenne and other types of muscular dystrophy and the Kugelberg-Welander syndrome showed marked sensitization to muscle and also to central and peripheral nervous antigens even in preclinical disease. These findings are discussed in relation to the pathogenesis of the disease.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000937:Antigen-Antibody Reactions; D002648:Child; D002675:Child, Preschool; D004586:Electrophoresis; D005121:Extremities; D005260:Female; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons; D009124:Muscle Proteins; D009133:Muscular Atrophy / Q000235:genetics; D009136:Muscular Dystrophies / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D009419:Nerve Tissue Proteins; D013118:Spinal Cord Diseases / Q000235:genetics
D009124:Muscle Proteins; D009419:Nerve Tissue Proteins