Human lymphocyte antigen reactivity modified by neuraminidase.
Human lymphocytes treated with neuraminidase (from Vibrio cholera) are more susceptible to lysis with antiserums directed against HL-A antigens in the cytotoxicity test than are the corresponding cells incubated in buffer. Enzymetreated cells are also lysed by antibodies other than those directed against HL-A, but control cells are not. The extra sensitivity to antibody disappears after 2 to 6 days in tissue culture.
D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D046508:Culture Techniques; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D009439:Neuraminidase / Q000494:pharmacology*
D009439:Neuraminidase