Prostaglandins and glaucoma.
Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active material were studied in aqueous humour obtained from cadavers; activity seemed to be due to prostaglandin E(1). These results suggest that prostaglandin E(1) may play some part in the aetiology of open angle glaucoma.
D000368:Aged; D001082:Aqueous Humor / Q000032:analysis*; D001681:Biological Assay; D002102:Cadaver; D002386:Cataract / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005260:Female; D005901:Glaucoma / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000032:analysis*; D013270:Stomach
D011453:Prostaglandins