title: The effect of light chloralose and pentobarbitone anaesthesia on the acid-base state and oxygenation of arterial blood in dogs.
abstract: 1. The effects of light anaesthesia of approximately 8 hr duration using either pentobarbitone or chloralose on the acid-base balance and oxygenation of arterial blood were determined in dogs breathing spontaneously.2. With pentobarbitone anaesthesia there was a slight initial respiratory acidaemia.3. With chloralose there was a non-respiratory acidaemia which was probably the result of using an unbuffered solvent.4. Changes in the acid-base balance and the oxygen concentration of the arterial blood over the course of each experiment were minimal.5. In one animal a pH of 7.07 was recorded; in others the oxygen tension on occasion was between 50 and 60 mm Hg. The value of monitoring the acid-base state and the oxygenation of blood in experimental preparations is discussed.
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000138:Acidosis; D000142:Acidosis, Respiratory; D000768:Anesthesia, General; D000818:Animals; D001158:Arteries; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000378:metabolism; D002698:Chloralose / Q000494:pharmacology*; D004285:Dogs; D006400:Hematocrit; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood*; D010424:Pentobarbital / Q000494:pharmacology*; D013696:Temperature
chemical_list: D001639:Bicarbonates; D002245:Carbon Dioxide; D002698:Chloralose; D010424:Pentobarbital; D010100:Oxygen