Duchenne muscular dystrophy: functional ischemia reproduces its characteristic lesions.
The highly characteristic early and midstage histological lesions of Duchenne dystrophy were reproduced experimentally in the rat by the combination of a vascular abnormality, aortic ligation, which does not affect the structure of the intramuscular blood vessels, and the humoral vasoactive substance 5-hydroxytryptamine. Neither ligation nor injection of 5-hydroxytryptamine alone causes changes in the muscle fibers. This result establishes the possibility of a similar combined mechanism for a nonstructural ischemia pathogenesis in Duchenne dystrophy. The proposed pathogenesis is contrary to the generally held idea that the cause is an intrinsic abnormality of muscle fiber metabolism.
D000818:Animals; D004195:Disease Models, Animal; D007511:Ischemia / Q000150:complications / Q000473:pathology*; D009136:Muscular Dystrophies / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin