Effects of long-term reserpine treatment on brain tyrosine hydroxylase and behavioral activity.
Treatment of rats with reserpine (for 8 or 9 days) produced a temporally related increase in behavioral activity and in tyrosine hydroxylase activity in the midbrain. Weight loss resulting from such treatment was not sufficient, by itself, to account for either the behavioral or enzymatic changes. The results support the role of catecholamines in behavioral arousal.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight; D001921:Brain / Q000201:enzymology*; D005508:Food Deprivation; D008297:Male; D006899:Mixed Function Oxygenases / Q000032:analysis*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014443:Tyrosine
D014443:Tyrosine; D012110:Reserpine; D006899:Mixed Function Oxygenases