Serum transaminases during salicylate therapy.
In 8 out of 32 juvenile patients suffering from chronic polyarthritis and in one patient with dermatomyositis, raised transaminase levels were found; the salicylate level was above 35 mg/100 ml in all except one. Reduction in the salicylate level led to a prompt fall in the serum transaminases. Despite a rise in alkaline phosphatase in three cases there was no other evidence of liver dysfunction in the children. Only one of the adults showed a rise in transaminase levels, and she had mild cirrhosis.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood; D001171:Arthritis, Juvenile / Q000188:drug therapy; D001219:Aspartate Aminotransferases / Q000097:blood*; D001241:Aspirin / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003882:Dermatomyositis / Q000188:drug therapy; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood; D008297:Male; D008875:Middle Aged; D012459:Salicylates / Q000097:blood
D012459:Salicylates; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001241:Aspirin