Preganglionic stimulation increases calcium uptake by sympathetic ganglia.
Isolated superior cervical ganglia of rats accumulate more calcium during preganglionic stimulation than do unstimulated controls; uptake of calcium-45 is approximately doubled by stimulation of 12 impulses per second. The extra uptake is markedly reduced by a high concentration of magnesium, but not by mecamylamine hydrochloride or tetraethylammonium chloride, although all three agents eliminate the postsynaptic action potential. Uptake of calcium-45 is also greatly increased by a high external concentration of potassium.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D002127:Calcium Isotopes; D003864:Depression, Chemical; D004558:Electric Stimulation; D005725:Ganglia, Autonomic / Q000378:metabolism*; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D008274:Magnesium / Q000494:pharmacology; D008464:Mecamylamine / Q000494:pharmacology; D009994:Osmolar Concentration; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000378:metabolism*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D002127:Calcium Isotopes; D007552:Isotonic Solutions; D013757:Tetraethylammonium Compounds; D008464:Mecamylamine; D008274:Magnesium; D011188:Potassium; D002118:Calcium