Release of dopamine from bovine lung by specific antigen and by compound 48-80.
1. Dopamine was shown to be released from the isolated lung of calves sensitized with horse serum by compound 48/80 and by specific antigen.2. Dopamine contracts the bovine pulmonary artery and pulmonary vein. Phentolamine, the alpha-adrenoceptor blocking agent, inhibits this activity of dopamine and also strongly reduces the Schultz-Dale response of the pulmonary vessels.3. The results are consistent with the suggestion that dopamine (together with histamine and 5-hydroxytryptamine) may participate in the pulmonary vasoconstriction associated with anaphylaxis in cattle.
D000707:Anaphylaxis / Q000503:physiopathology; D000818:Animals; D000941:Antigens; D002417:Cattle; D004298:Dopamine / Q000378:metabolism*; D006736:Horses; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects; D011667:Pulmonary Veins / Q000187:drug effects; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D000941:Antigens; D003189:p-Methoxy-N-methylphenethylamine; D004298:Dopamine; D010646:Phentolamine