Oxidative N-dealkylation: a mannich intermediate in the formation of a new metabolite of lidocaine in man.
Evidence is presented for a new metabolite of lidocaine. Its structure, N(1)-ethyl-2-methyl-N(3)-(2,6-dimethylphenyl)-4-imidazolidinone, suggests reactive electrophilic intermediates for the oxidative removal of N-alkyl groups in general.
D000284:Administration, Oral; D000478:Alkylation; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D003640:Dealkylation; D005243:Feces / Q000032:analysis; D006801:Humans; D007093:Imidazoles / Q000096:biosynthesis* / Q000652:urine; D007659:Ketones / Q000032:analysis / Q000652:urine; D008012:Lidocaine / Q000008:administration & dosage / Q000378:metabolism*; D010084:Oxidation-Reduction
D007093:Imidazoles; D007659:Ketones; D008012:Lidocaine