title: Negative chronotropic effects of McN A-343 and nicotine in isolated guinea-pig atria: insensitivity to blockade by tetrodotoxin.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D001285:Atropine / Q000494:pharmacology; D002219:Carbamates / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004594:Electrophysiology; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011984:Sensory Receptor Cells / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000494:pharmacology*; D014630:Vagus Nerve / Q000187:drug effects
chemical_list: D002219:Carbamates; D006584:Hexamethonium Compounds; D000644:Quaternary Ammonium Compounds; D013566:Sympathomimetics; D013779:Tetrodotoxin; D009538:Nicotine; D001285:Atropine