L-dopa: disaggregation of brain polysomes and elevation of brain tryptophan.
One hour after administration of L-dopa (50 to 300 milligrams per kilogram), there is a marked disaggregation of brain polysomes in immature rats. Adult animals show a similar response, but require larger doses of the amino acid (500 milligrams per kilogram). Single doses of L-dopa significantly elevate amounts of tryptophan in the brain; hence their effect on polysomes does not result from the unavailability of this amino acid.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000494:pharmacology*; D010649:Phenylalanine / Q000494:pharmacology; D051381:Rats; D012270:Ribosomes / Q000187:drug effects*; D013997:Time Factors; D014364:Tryptophan / Q000032:analysis*; D014443:Tyrosine / Q000494:pharmacology
D014443:Tyrosine; D010649:Phenylalanine; D004295:Dihydroxyphenylalanine; D014364:Tryptophan