The induction of ATP energized mitochondrial volume changes by carcinogenic N-hydroxy-N-acetyl-aminofluorenes when combined with showdomycin. A unitary hypothesis for carcinogenesis.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001665:Binding Sites; D002273:Carcinogens / Q000008:administration & dosage; D005449:Fluorenes / Q000008:administration & dosage / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008293:Malates / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009840:Oligomycins / Q000008:administration & dosage; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D013439:Sulfhydryl Reagents / Q000494:pharmacology; D014449:Tyrothricin / Q000037:antagonists & inhibitors
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D002273:Carcinogens; D005449:Fluorenes; D008293:Malates; D009840:Oligomycins; D013439:Sulfhydryl Reagents; D014449:Tyrothricin; D000255:Adenosine Triphosphate; D011188:Potassium