Differences in the interaction of 2,3-diphosphoglycerate with certain mammalian hemoglobins.
The hemoglobins of man, horse, dog, rabbit, guinea pig, and rat all have relatively high (nonphysiologic) oxygen affinity when stripped of organic phosphates, and a strong reactivity with 2,3-diphosphoglycerate (2,3-DPG). Appropriately, their red cells contain high levels of 2,3-DPG. In contrast, the sheep, goat, cow, and cat have low oxygen affinity hemoglobins which interact weakly with 2,3-DPG, and low concentrations of red cell 2,3-DPG. These hemoglobins have structural differences at the NH(2)-terminus of the beta chain, a site where 2,3-DPG is thought to bind.
D000595:Amino Acid Sequence; D000818:Animals; D002415:Cats; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism*; D005988:Glyceric Acids / Q000097:blood*; D006041:Goats; D006168:Guinea Pigs; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D010100:Oxygen / Q000097:blood; D010455:Peptides; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D012756:Sheep
D005988:Glyceric Acids; D006454:Hemoglobins; D010455:Peptides; D010100:Oxygen