title: Progeria: a cell culture study on aging.
abstract: Progeria is an autosomal recessive disorder showing precocious senility. The cultured skin fibroblast from both the homozygous affected individual and the heterozygous parents can be distinguished from normals by decreased cell growth in culture. Mitotic activity, DNA synthesis, and cloning efficiency are markedly reduced.
mesh_terms: D000375:Aging; D002999:Clone Cells; D046508:Culture Techniques; D003582:Cytogenetics; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D005808:Genes, Recessive; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008938:Mitosis; D011371:Progeria / Q000235:genetics / Q000378:metabolism*; D012867:Skin / Q000166:cytology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014898:Werner Syndrome
chemical_list: D014316:Tritium; D004247:DNA; D013936:Thymidine