Recovery of prostaglandins in human cutaneous inflammation.
An in-vivo skin perfusion technique has been used to study the pharmacological activity in inflamed skin of patients with allergic contact eczema. Perfusates from 35 out of 45 patients contained a smooth-muscle-contracting agent with prostaglandin-like properties. Solvent partition followed by thinlayer chromatography revealed this activity to be due to a mixture of prostaglandins E and F. This direct evidence supports the view that prostaglandins mediate inflammation in man.
D000818:Animals; D002855:Chromatography, Thin Layer; D003877:Dermatitis, Contact / Q000378:metabolism*; D004485:Eczema / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010477:Perfusion; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats
D005227:Fatty Acids; D011453:Prostaglandins