Oral therapy of diabetes insipidus with chlorpropamide.
Chlorpropamide was found to be an effective antidiuretic agent in vasopressin-sensitive diabetes insipidus. Full clinical use of this action is limited by the frequent occurrence of hypoglycemia on higher doses. This complication can be avoided, however, by restricting the dose and by employing combination therapy with hydrochlorothiazide.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002747:Chlorpropamide / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D007003:Hypoglycemia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged
D006852:Hydrochlorothiazide; D002747:Chlorpropamide