Uptake and release of  14 C-5-hydroxytryptamine by platelets in affective illness.
In the search for paradigms of postulated abnormalities in indolamine function in the brain in affective disorders, 5-HT uptake and release was estimated in platelets from patients suffering from severe depressive illness. Neither of these measures was altered by the illness and the most likely explanation for the negative findings was that in this setting platelets are not a suitable model.
D000588:Amines / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D003863:Depression / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000378:metabolism; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
D000588:Amines; D002247:Carbon Isotopes; D007211:Indoles; D012701:Serotonin