Inhibition of biogenic amine uptake by hydrogen peroxide: a mechanism for toxic effects of 6-hydroxydopamine.
Hydrogen peroxide, dialuric acid, or 6-hydroxydopamine inhibited the uptake of dopamine, norepinephrine, and serotonin into rat brain synaptosomal preparations. The addition of catalase protected all systems, but catalase was only partially protective for 6-hydroxydopamine acting upon catecholamine uptake. The data show that 6-hydroxydopamine generates hydrogen peroxide and that hydrogen peroxide can damage the biogenic amine uptake systems. Part of the damage caused by the 6-hydroxydopamine that accumulates in the catecholamine nerve terminals in vivo may be attributed to the hydrogen peroxide.
D000588:Amines / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002374:Catalase / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000096:biosynthesis / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D010627:Phenethylamines / Q000633:toxicity*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013572:Synaptic Vesicles / Q000378:metabolism; D014316:Tritium
D000588:Amines; D010627:Phenethylamines; D014316:Tritium; D012701:Serotonin; D006861:Hydrogen Peroxide; D002374:Catalase; D004298:Dopamine; D009638:Norepinephrine