Hycanthone: a frameshift mutagen.
Rapid spot-test screening of antischistosomal agents reveals that hycanthone is a potent frameshift mutagen while the closely related compound, miracil D, is nonmutagenic in Salmonella. Both hycanthone and miracil D are frameshift mutagens for T4 bacteriophage during growth in Escherichia coli.
D000871:Anthelmintics / Q000494:pharmacology*; D003090:Coliphages / Q000187:drug effects; D006639:Histidine / Q000378:metabolism; D008154:Lucanthone / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D012475:Salmonella / Q000187:drug effects; D014966:Xanthenes / Q000494:pharmacology*
D000871:Anthelmintics; D009153:Mutagens; D014966:Xanthenes; D006639:Histidine; D008154:Lucanthone