Thalassemia and G-6-PD deficiency in Chinese-Canadians: admission screening of a hospital population.
Admission screening was performed on 684 Chinese-Canadian patients for thalassemia, abnormal hemoglobins and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Thirty-six healthy Chinese adults were also studied. The incidence of beta-thalassemia minor (hemoglobin A(2) greater than 3.5%) was 3.8%. Presumptive alpha-thalassemia minor (demonstration of occasional red cells containing hemoglobin H inclusion bodies) was found in 6.7%. Two patients had findings consistent with alpha-beta-thalassemia. The incidence of G-6-PD deficiency (abnormal methemoglobin reduction test) in adult males was 4.7%. In a parallel study the incidence of hemoglobin Bart's in 310 Chinese newborns was 6.8%. Two mutant hemoglobins were found - hemoglobin E and hemoglobin J (Bangkok).
D000328:Adult; D000367:Age Factors; D044466:Asian People; D001797:Blood Protein Electrophoresis; D002170:Canada; D002848:Chromatography, DEAE-Cellulose; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000166:cytology; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology / Q000453:epidemiology; D006400:Hematocrit; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007501:Iron / Q000097:blood; D008297:Male; D008875:Middle Aged; D009996:Osmotic Fragility; D012737:Sex Factors; D013789:Thalassemia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D014470:Umbilical Cord
D006455:Hemoglobins, Abnormal; D007501:Iron