title: Free radical inhibitory effect of some anticancer compounds.
abstract: Conventional tests for polymerization initiated by free radicals indicate that alkylating agents vary in free radical inhibitory activity from negligible to moderately strong; antimetabolites from negligible to weak; hormones, steroids, and phenolics from very weak to very strong; and antibiotics from moderate to very strong. Vitamins A and C and copper, which potentiate the biological activity of some anticancer compounds, are relatively strong free radical inhibitors.
mesh_terms: D000447:Aldehydes / Q000494:pharmacology; D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000963:Antimetabolites / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D004357:Drug Synergism; D005609:Free Radicals / Q000037:antagonists & inhibitors; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D006918:Hydroxyurea / Q000494:pharmacology; D051379:Mice; D010636:Phenols / Q000494:pharmacology; D011241:Prednisone / Q000494:pharmacology; D014801:Vitamin A / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000477:Alkylating Agents; D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D000970:Antineoplastic Agents; D002219:Carbamates; D003374:Coumarins; D005609:Free Radicals; D012739:Gonadal Steroid Hormones; D010636:Phenols; D014801:Vitamin A; D003300:Copper; D001205:Ascorbic Acid; D011241:Prednisone; D006918:Hydroxyurea