Brain histamine: rapid apparent turnover altered by restraint and cold stress.
Histamine content of rat brain was lowered quickly by inhibitors of histidine decarboxylase, suggesting that a portion of brain histamine turns over rapidly. Restraint and exposure to cold also reduced brain histamine levels and markedly augmented its formation in the hypothalamus.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors; D002540:Cerebral Cortex / Q000032:analysis; D003080:Cold Temperature; D003408:Cresols / Q000494:pharmacology; D006632:Histamine / Q000032:analysis / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism; D006834:Hydrazines / Q000494:pharmacology; D007031:Hypothalamus / Q000032:analysis / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000032:analysis; D008636:Mesencephalon / Q000032:analysis; D011149:Pons / Q000032:analysis; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*; D013788:Thalamus / Q000032:analysis; D014316:Tritium
D003408:Cresols; D006834:Hydrazines; D014316:Tritium; D006639:Histidine; D006632:Histamine; D002262:Carboxy-Lyases