Melatonin and abnormal movements induced by L-dopa in mice.
Melatonin has blocked adventitious movements induced by L-dopa in intact mice. It has reversed the adventitious turning to the right, and it has induced running to the left in mice receiving L-dopa after a lesion in the right caudate nucleus.
D000284:Administration, Oral; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000503:physiopathology / Q000601:surgery; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000633:toxicity*; D004298:Dopamine / Q000302:isolation & purification; D004336:Drug Antagonism; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D009069:Movement Disorders / Q000139:chemically induced* / Q000209:etiology; D012701:Serotonin / Q000302:isolation & purification; D013997:Time Factors
D012701:Serotonin; D004295:Dihydroxyphenylalanine; D009074:Melanocyte-Stimulating Hormones; D001058:Apomorphine; D004298:Dopamine