Anaesthetic-induced malignant hyperpyrexia: a suggested method of treatment.
Experiments in susceptible Landrace pigs have shown that procaine blocks the initiation of anaesthetic-induced malignant hyperpyrexia by both halothane and succinylcholine. Pretreatment with curare prevents only the trigger action of succinylcholine. In a preliminary study procaine was used to treat the established syndrome in five pigs, two of which survived. On the basis of these findings a treatment regimen can be suggested for patients who develop malignant hyperpyrexia.
D000138:Acidosis / Q000188:drug therapy; D000768:Anesthesia, General / Q000009:adverse effects*; D000818:Animals; D001639:Bicarbonates / Q000627:therapeutic use; D003472:Curare / Q000627:therapeutic use; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy*; D006221:Halothane / Q000037:antagonists & inhibitors; D011343:Procaine / Q000627:therapeutic use*; D013390:Succinylcholine / Q000037:antagonists & inhibitors; D013552:Swine
D001639:Bicarbonates; D011343:Procaine; D003472:Curare; D013390:Succinylcholine; D006221:Halothane