Mechanism of cholestasis. 3. Interaction of synthetic detergents with the microsomal cytochrome P-450 dependentbiotransformation system in vitro. A comparison between the effects of detergents, the effects of bile acids, and the findings in bile duct ligated rats.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D001652:Bile Ducts / Q000502:physiology; D001711:Biotransformation; D002779:Cholestasis / Q000209:etiology; D003580:Cytochromes / Q000378:metabolism*; D003640:Dealkylation; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D013053:Spectrophotometry; D013501:Surface-Active Agents / Q000494:pharmacology*
D000814:Aniline Compounds; D001647:Bile Acids and Salts; D003580:Cytochromes; D013501:Surface-Active Agents; D000632:Aminopyrine; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases