Effect of chlorite-oxidized oxyamylose on influenza virus infection in mice.
Intraperitoneally administered chlorite-oxidized oxyamylose (COAM) provided protection of mice against intranasal infection with several influenza virus strains. Treated animals invariably showed a reduced consolidation of the lungs and, in the case of infection with lethal strains of virus, also a delay in mortality. With a small dose of influenza A/PR8 virus, an increase in final survival rate could be observed. The effect of COAM on influenza virus infection lasted for at least 4 to 8 days. Inhibition of lung consolidation was not paralleled by a decrease in virus multiplication in the lung. The significance of this finding in relation to the mechanism of the antiviral action of COAM is discussed.
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D002264:Carboxylic Acids / Q000627:therapeutic use; D002713:Chlorine; D004195:Disease Models, Animal; D005260:Female; D006389:Hemagglutinins, Viral / Q000032:analysis; D007274:Injections, Intraperitoneal; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D009976:Orthomyxoviridae Infections / Q000382:microbiology / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D010084:Oxidation-Reduction; D011134:Polysaccharides; D013045:Species Specificity; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D002264:Carboxylic Acids; D006389:Hemagglutinins, Viral; D011134:Polysaccharides; D002713:Chlorine