Cardiorespiratory effects of intravenous isoprenaline and salbutamol in dogs.
1. The cardiorespiratory effects of intravenous infusions of isoprenaline and salbutamol (1 and 5 mug/min) have been compared in twelve dogs.2. Both drugs produced a rise in pulse rate, a fall in systemic arterial pressure and a rise in pulmonary arterial pressure. Salbutamol produced a greater increase in cardiac output than isoprenaline.3. Both drugs produced an increase in venous admixture, but a significant fall in arterial oxygen tension occurred only with isoprenaline at the higher dose.
D000818:Animals; D001158:Arteries; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D011650:Pulmonary Alveoli / Q000187:drug effects; D011651:Pulmonary Artery; D011652:Pulmonary Circulation / Q000187:drug effects; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*; D013147:Spirometry
D001993:Bronchodilator Agents; D002245:Carbon Dioxide; D000431:Ethanol; D007545:Isoproterenol; D010100:Oxygen