Transport of nitrogen mustard on the transport-carrier for choline in L5178Y lymphoblasts.
The uptake of choline by L5178Y lymphoblasts occurs by a carrier mechanism and is an active process. Transport of nitrogen mustard and its hydrolyzed derivative is mediated by this same carrier. This finding is an example of drug transport by a carrier whose primary function is transport of a naturally occurring substrate.
D001692:Biological Transport; D002247:Carbon Isotopes; D002794:Choline / Q000378:metabolism*; D046508:Culture Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism*; D008466:Mechlorethamine / Q000378:metabolism*
D002247:Carbon Isotopes; D008466:Mechlorethamine; D002794:Choline