Hereditary renal disease in a mutant strain of rats.
Disease of the kidney developed in breeding stock of Gunn rats. The renal lesion is the result of a new mutation. The genetic defect is inherited as an autosomal dominant trait and is apparently lethal in the homozygous condition. The abnormality manifests itself as a congenital hydronephrosis with related cystic changes in the kidney.
D000818:Animals; D005799:Genes, Dominant; D006579:Heterozygote; D006720:Homozygote; D006869:Hydronephrosis / Q000151:congenital* / Q000473:pathology; D007565:Jaundice / Q000235:genetics; D007674:Kidney Diseases / Q000235:genetics*; D052177:Kidney Diseases, Cystic / Q000235:genetics* / Q000473:pathology; D008954:Models, Biological; D009154:Mutation; D051381:Rats; D012376:Rodent Diseases; D014567:Urography