"Hemoglobin alpha2beta2-121ys" chemical identification in an egyptian family.
Stuidy of the amino acid composition and amino-terminal residue in the abnormal peptide of an electrophoretically slow hemoglobin revealed that the globin's structure was alpha(2)beta(2)(121 Lys) (Obeta). This hemoglobin had been provisionally classified as Hb E or as a new heemoglobin. The clinical significance of this abnormality is not yet defined.
D000595:Amino Acid Sequence; D001797:Blood Protein Electrophoresis; D002854:Chromatography, Paper; D004140:Dinitrophenols; D004534:Egypt; D005826:Genetics, Medical; D005914:Globins / Q000032:analysis; D005971:Glutamates; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006579:Heterozygote; D006801:Humans; D008239:Lysine; D008967:Molecular Biology; D010455:Peptides / Q000032:analysis*; D014357:Trypsin
D004140:Dinitrophenols; D005971:Glutamates; D006455:Hemoglobins, Abnormal; D010455:Peptides; D005914:Globins; D014357:Trypsin; D008239:Lysine