The titration curve of insulin in the presence of various bivalent metal ions.
1. Titration curves of insulin in the presence and absence of various metal ions are reported. 2. The difference in base consumption with and without the metal ions is compared with calculated curves. 3. These experiments suggest that in dilute solutions Zn(2+) and Cu(2+) ions are bound to alpha-amino groups.
D003300:Copper; D006863:Hydrogen-Ion Concentration; D007328:Insulin; D007854:Lead; D008433:Mathematics; D011485:Protein Binding; D015032:Zinc
D007328:Insulin; D007854:Lead; D003300:Copper; D015032:Zinc