Macrophage cultures: an extracellular esterase.
An enzyme having esterase activity accumulates in the culture media of mouse peritoneal mononuclear leukocytes during differentiation of the cells into macrophages. It has a pH optimum of 6.5 and shows aryl esterase characteristics. The esterase differs from another macrophage hydrolase, acid phosphatase, in its mainly extracellular distribution.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D002729:Chloromercuribenzoates / Q000494:pharmacology; D003470:Culture Media; D046508:Culture Techniques; D004950:Esterases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008264:Macrophages; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000201:enzymology*; D009281:Naphthalenes
D002729:Chloromercuribenzoates; D003470:Culture Media; D009281:Naphthalenes; D004950:Esterases; D000135:Acid Phosphatase