Selective gene transcription in bacteriophage T4 by putrescine.
Messenger ribonucleic acid (mRNA) preparations from T4-infected cells formed in the presence or absence of putrescine have been characterized and compared. Hybrid competition experiments indicate that these mRNA molecules are derived from distinct genetic loci. The results are consistent with the hypothesis that putrescine might control differential transcription of the phage genome during morphogenesis. The data are also in accord with previously observed changes in the population of mRNA formed at different times after infection.
D002082:Butylamines / Q000494:pharmacology*; D002247:Carbon Isotopes; D003090:Coliphages / Q000187:drug effects*; D004279:DNA, Viral / Q000096:biosynthesis* / Q000302:isolation & purification; D005827:Genetics, Microbial / Q000187:drug effects*; D012333:RNA, Messenger / Q000096:biosynthesis*; D012367:RNA, Viral / Q000096:biosynthesis* / Q000302:isolation & purification; D013941:Thymine; D014316:Tritium; D014529:Uridine; D014764:Viral Proteins / Q000096:biosynthesis
D002082:Butylamines; D002247:Carbon Isotopes; D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral; D014764:Viral Proteins; D014316:Tritium; D013941:Thymine; D014529:Uridine