Activation of fatty acid synthesis in cell-free extracts of Saccharomyces cerevisiae.
Fatty acid synthesis from acetate in extracts of Saccharomyces cerevisiae strain LK2G12 was shown to be stimulated by alpha-glycerophosphate and citrate, and by a number of compounds related to them. Magnesium was shown to stimulate fatty acid synthesis from acetyl-coenzyme A but not from malonyl-coenzyme A, thus indicating the site of stimulation of fatty acid synthesis to be the acetyl-coenzyme A step.
D002247:Carbon Isotopes; D002474:Cell-Free System; D002951:Citrates / Q000494:pharmacology; D003065:Coenzyme A / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D005994:Glycerophosphates / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D012440:Saccharomyces / Q000187:drug effects / Q000378:metabolism*
D002247:Carbon Isotopes; D002951:Citrates; D005227:Fatty Acids; D005994:Glycerophosphates; D008345:Manganese; D008274:Magnesium; D003065:Coenzyme A