Hypocholesterolemic activity of 17-alpha-methyl-5-alpha-androstane-3-beta, 17-beta-diol, a metabolite of 17-alpha-methyltestosterone.
The hypocholesterolemic activities of 17alpha-methyltestosterone and its major identified fecal metabolite, 17alpha-methyl-5alpha-androstane-3,17-diol, were compared in dogs. The dose-response curves indicated that the two compounds had similar effects, although at doses below 1 mg/kg per day the diol appeared to be more active than the parent compound.
D000731:Androstanes / Q000494:pharmacology*; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D004285:Dogs; D005260:Female; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008777:Methyltestosterone / Q000494:pharmacology*; D014461:Ultracentrifugation
D000731:Androstanes; D000924:Anticholesteremic Agents; D008074:Lipoproteins; D002784:Cholesterol; D008777:Methyltestosterone