Immunosuppressant from group A streptococci.
A cytoplasmic component of group A streptococci suppresses both 19S and 7S antibody responses of mice to sheep erythrocytes. Partial purification is achieved by differential centrifugation and gel filtration. When the direct and indirect hemolytic plaque techniques are used, a single injection of this group A material given before injection of erythrocytes produces more than 90-percent suppression of either primary or secondary immune response.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002498:Centrifugation; D002850:Chromatography, Gel; D003864:Depression, Chemical; D004912:Erythrocytes; D006460:Hemolysin Proteins / Q000096:biosynthesis; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents / Q000032:analysis / Q000494:pharmacology*; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013291:Streptococcus / Q000166:cytology*
D006460:Hemolysin Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents