Hemoglobin variant common to Chinese and North American Indians: alpha-2-beta-22 Glu-Ala.
An electrophoretically slow hemoglobin variant, in which the structural change involves the replacement of a glutamyl residue by alanyl at position beta-22, was reported in two groups of North American Indians: hemoglobin-G Coushatta, in Alabama-Coushatta Indians in Texas; and hemoglobin-G Saskatoon, in descendants of Santee Indians living in Canada. Hemoglobin-G Hsin-Chu, found in Taiwan in a Chinese from the northern Chinese province of Liaoning, is now shown to have the same structural anomaly.
D000409:Alanine; D000595:Amino Acid Sequence; D044466:Asian People; D001797:Blood Protein Electrophoresis; D002170:Canada; D002854:Chromatography, Paper; D005971:Glutamates; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007198:Indians, North American; D010455:Peptides / Q000032:analysis*; D013624:Taiwan; D013781:Texas
D005971:Glutamates; D006455:Hemoglobins, Abnormal; D010455:Peptides; D000409:Alanine