4-Leucine-oxytocin: natriuretic, diuretic, and antivasopressin polypeptide.
During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance.
D000042:Absorption; D000818:Animals; D002712:Chlorides / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D007684:Kidney Tubules / Q000502:physiology; D007930:Leucine; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D009994:Osmolar Concentration; D010121:Oxytocin / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D051381:Rats; D013268:Stimulation, Chemical; D014667:Vasopressins / Q000037:antagonists & inhibitors; D014882:Water-Electrolyte Balance
D002712:Chlorides; D010455:Peptides; D014667:Vasopressins; D010121:Oxytocin; D007930:Leucine; D011188:Potassium