Antifungal activity of isothiocyanates and related compounds. 3. Derivatives of biphenyl, stilbene, azobenzene, and several polycondensed aromatic hydrocarbons.
This paper presents the results of a study on the antifungal activity of isothiocyanates-derivatives of biphenyl (group "A"), of stilbene ("B"), of azobenzene and benzeneazonaphthalene ("C"), of naphthalene ("D"), and of further polycondensed aromatic hydrocarbons ("E"). From a total of 48 investigated compounds, antifungal activity was observed only in A and D group compounds. B, C, and E group derivatives are extremely insoluble in water, and the molecules are very large; as a result, they probably cannot pass into spores or mycelium of fungi. Thus, the -NCS group cannot manifest its reactivity.
D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D001391:Azo Compounds / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006838:Hydrocarbons / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology*; D010407:Penicillium / Q000187:drug effects; D012233:Rhizopus / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology; D013861:Thiocyanates / Q000494:pharmacology*
D000935:Antifungal Agents; D001391:Azo Compounds; D001713:Biphenyl Compounds; D006838:Hydrocarbons; D009281:Naphthalenes; D013267:Stilbenes; D013861:Thiocyanates