Prevention of radiation-induced creatinuria by insulin.
Insulin completely suppressed creatinuria in rats x-irradiated with an absorbed dose of 500 rads. The hormone may exert this effect either by restoring or maintaining the ability of irradiated muscle to take up creatine from the extra-cellular fluid at a normal rate, or possibly by influencing the synthesis or breakdown of phosphorylcreatine.
D000818:Animals; D003401:Creatine / Q000378:metabolism* / Q000652:urine*; D005110:Extracellular Space / Q000378:metabolism; D007328:Insulin; D008297:Male; D008659:Metabolic Diseases / Q000652:urine*; D009132:Muscles / Q000378:metabolism / Q000528:radiation effects; D010725:Phosphocreatine / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D051381:Rats
D007328:Insulin; D011837:Radiation-Protective Agents; D010725:Phosphocreatine; D003401:Creatine