Drug resistance of staphylococci. VI. Genetic determinant for chloramphenicol resistance.
Naturally occurring strains of staphylococci which are resistant to chloramphenicol (CM) inactivate this antibiotic. One of the inactivation products of CM showed the chromatographic behavior of 3-acetoxychloramphenicol. Induction of resistance occurred after prior exposure to subinhibitory concentrations of the antibiotic. The resistance of induced populations, as well as CM-inactivation ability, was decreased when they were grown in CM-free medium. The CM-inactivation property was transduced together with CM resistance. Transductional analysis and CM-resistance elimination experiments indicated that CM resistance in naturally occurring strains of staphylococci is mainly accounted for by inactivation of the drug.
D000166:Acridines / Q000494:pharmacology; D002701:Chloramphenicol / Q000378:metabolism / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004790:Enzyme Induction; D006801:Humans; D013210:Staphylococcus / Q000187:drug effects*; D014161:Transduction, Genetic
D000166:Acridines; D002701:Chloramphenicol