Creatine kinase and aldolase in serum: abnormality common to acute psychoses.
Activity of creatine kinase and aldolase in serum increased in 14 of 16 patients with recent onset of a psychotic reaction, and in five of six patients treated with psychotomimetic drugs. There was either no increase of these enzymes or a slight increase in severely agitated (or depressed) non-psychotic hospitalized patients and chronic psychotic patients. The increase of the enzymes preceded the onset of the acute psychotic symptoms in at least three cases, was highest during the first 2 weeks of a psychotic episode, and sometimes recurred throughout the illness, particularly at times of stress. The creatine kinase in the serum is primarily of the muscle type.
D001007:Anxiety; D001714:Bipolar Disorder / Q000097:blood*; D002389:Catatonia / Q000097:blood*; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D003863:Depression / Q000097:blood; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood*; D006213:Hallucinogens / Q000627:therapeutic use; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000627:therapeutic use; D001523:Mental Disorders / Q000097:blood; D008960:Models, Psychological; D009132:Muscles / Q000201:enzymology; D010259:Paranoid Disorders / Q000097:blood*; D010554:Personality Disorders / Q000097:blood; D011618:Psychotic Disorders / Q000097:blood* / Q000175:diagnosis; D012559:Schizophrenia / Q000097:blood*; D014363:Tryptamines / Q000627:therapeutic use
D006213:Hallucinogens; D014363:Tryptamines; D008238:Lysergic Acid Diethylamide; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase