Biosynthesis of putrescine in the prostate gland of the rat.
In the rat ventral prostate gland the biosynthesis of putrescine, a precursor of spermidine and spermine, is shown to occur by the direct decarboxylation of l-ornithine. Some properties of a soluble pyridoxal phosphate-dependent l-ornithine decarboxylase are described. The findings are discussed in relation to other enzymic reactions involved in the biosynthesis of polyamines by the prostate gland.
D000588:Amines / Q000096:biosynthesis* / Q000494:pharmacology; D000818:Animals; D002247:Carbon Isotopes; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009952:Ornithine; D011467:Prostate / Q000201:enzymology / Q000378:metabolism*; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D013096:Spermine / Q000494:pharmacology; D013268:Stimulation, Chemical
D000588:Amines; D002247:Carbon Isotopes; D013096:Spermine; D011732:Pyridoxal Phosphate; D009952:Ornithine; D002262:Carboxy-Lyases