Cellular immunity in vaccinia infection of mice. Anti-thymocyte serum effects on primary and secondary responsiveness.
Rabbit anti-mouse thymocyte serum suppressed host cell-mediated responsiveness to intravenously administered vaccinia virus, thereby augmenting the morbidity and mortality of this infection. It did not affect either humoral antibody or interferon production in response to vaccinia virus. No effects were noted on primary or secondary immunity to intracerebral virus inoculation.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D006385:Hemagglutination Inhibition Tests; D007106:Immune Sera; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007372:Interferons / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology; D014615:Vaccinia / Q000276:immunology*
D000906:Antibodies; D007106:Immune Sera; D007372:Interferons