Interaction of staphylococcal penicillinase and 6-[D(-)-alphaguanidino-phenylacetamido]-penicillanic acid.
6[d(-)-alpha-Guanidinophenylacetamido]-penicillanic acid was shown to be significantly hydrolyzed by only one of six preparations of staphylococcal penicillinase. This penicillin analogue is a stronger penicillinase inactivator than are nafcillin and methicillin, which were not significantly hydrolyzed by the enzyme.
D008365:Manometry; D008712:Methicillin / Q000378:metabolism; D009254:Nafcillin / Q000378:metabolism; D010068:Oxacillin / Q000378:metabolism; D010400:Penicillin G / Q000378:metabolism; D010405:Penicillinase / Q000378:metabolism*; D010406:Penicillins / Q000378:metabolism*; D013210:Staphylococcus / Q000201:enzymology*
D010406:Penicillins; D009254:Nafcillin; D010405:Penicillinase; D010400:Penicillin G; D008712:Methicillin; D010068:Oxacillin