Alteration of tryptophan-mediated regulation in Neurospora crassa by indoleglycerol phosphate.
The accumulation of imidazoleglycerol phosphate during growth of Neurospora crassa in the presence of 3-amino-1,2,4-triazole was found to cause derepression of tryptophan synthetase and to inhibit the induction of kynureninase. Accumulation of indoleglycerol phosphate in response to growth in the presence of indole acrylic acid or anthranilic acid was also accompanied by derepressed synthesis of tryptophan synthetase. Enzyme synthesis in mutants (his-7 and trp-4) unable to form these intermediates was not altered under similar conditions. The rate of formation of tryptophan synthetase and kynureninase was found to differ in the presence of tryptophan and indole.
D004790:Enzyme Induction; D006867:Hydrolases / Q000096:biosynthesis*; D007093:Imidazoles / Q000378:metabolism; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology; D007737:Kynurenine / Q000378:metabolism; D008025:Ligases / Q000096:biosynthesis*; D008967:Molecular Biology; D009154:Mutation; D009491:Neurospora / Q000201:enzymology / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism* / Q000494:pharmacology
D007093:Imidazoles; D007211:Indoles; D007737:Kynurenine; D014364:Tryptophan; D006867:Hydrolases; D008025:Ligases