Bone marrow colony-stimulating activity of sera in infectious mononucleosis.
From 44 to 100% of sera from patients with infectious mononucleosis exhibited the capacity to stimulate colony formation in vitro by mouse bone marrow cells. The proportion of sera with colony-stimulating activity was highest in patients with a short fever period and developing low Paul-Bunnell titres. Patients with a more severe course of the disease generally displayed no, or only weak, colony-stimulating activity in their sera, and also had higher Paul-Bunnell titres. The level of serum colony-stimulating activity tended to fall in the convalescent stages of the disease.
D000328:Adult; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D046508:Culture Techniques; D005334:Fever; D006410:Hematopoiesis; D006801:Humans; D007244:Infectious Mononucleosis / Q000097:blood* / Q000276:immunology; D051379:Mice; D013268:Stimulation, Chemical