Dimethyl sulfoxide: interactions with aromatic hydrocarbons.
Dimethyl sulfoxide (DMSO) enhanced the hypertaurinuria produced by benzene, chlorobenzene, and toluene in rats. Undiluted DMSO was more effective than DMSO diluted with water in potentiating the toxicity of benzene in both rats and mice. Supernatants (9000g) prepared from livers of rats treated with DMSO 24 hours earlier metabolized more benzene than those from control rats.
D000818:Animals; D001554:Benzene / Q000378:metabolism / Q000633:toxicity*; D002247:Carbon Isotopes; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004357:Drug Synergism; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013654:Taurine / Q000652:urine; D014050:Toluene / Q000633:toxicity*
D002247:Carbon Isotopes; D006846:Hydrocarbons, Halogenated; D013654:Taurine; D014050:Toluene; D001554:Benzene; D004121:Dimethyl Sulfoxide