Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis. Anti-gamma-globulin factors and their interaction with specific opsonins.
The effect of anti-gamma-globulin factors on 7S gamma-globulin opsonins from patients with subacute bacterial endocarditis has been examined with a quantitative in vitro phagocytosis system. Human anti-gamma-globulin factors from patients with subacute bacterial endocarditis and rheumatoid arthritis inhibited the opsonic action of 7S gamma-globulin specifically bound to bacteria. A similar antiopsonic effect was obtained with rabbit antiserum to human gammaG globulin. The antiopsonic effect of anti-gamma-globulin factors did not correlate with their ability to potentiate agglutination of bacteria by 7S antibody. Competition was demonstrated between the antiopsonic effect of anti-gamma-globulin factors and the phagocytosis-promoting action of heat-labile serum factors containing hemolytically active complement.
D000372:Agglutination Tests; D001172:Arthritis, Rheumatoid; D003298:Coombs Test; D004698:Endocarditis, Subacute Bacterial / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G; D007962:Leukocytes; D009895:Opsonin Proteins; D010587:Phagocytosis; D012217:Rheumatoid Factor; D013210:Staphylococcus / Q000276:immunology*
D007074:Immunoglobulin G; D009895:Opsonin Proteins; D012217:Rheumatoid Factor