Ciguatoxin: more than an anticholinesterase.
Anticholinesterase action of ciguatoxin has been reported. A study of the pharmacology of the action of the toxin on the respiratory system suggests that additional properties may be involved in the respiratory failure-the usual cause of death in ciguatera poisoning.
D000109:Acetylcholine / Q000633:toxicity; D000818:Animals; D001049:Apnea / Q000139:chemically induced; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D005260:Female; D005400:Fishes, Poisonous; D005517:Foodborne Diseases; D007274:Injections, Intraperitoneal; D010277:Parasympathomimetics / Q000633:toxicity*; D010278:Parathion / Q000633:toxicity; D010830:Physostigmine / Q000633:toxicity; D051381:Rats; D011955:Receptors, Drug; D012119:Respiration / Q000187:drug effects*; D012137:Respiratory System / Q000187:drug effects; D014118:Toxins, Biological / Q000633:toxicity*; D014628:Vagotomy
D002800:Cholinesterase Inhibitors; D010277:Parasympathomimetics; D011955:Receptors, Drug; D014118:Toxins, Biological; D010278:Parathion; D010830:Physostigmine; D000109:Acetylcholine