Effect of p-chlorophenoxyisobutyrate (CPIB) fed to rats on hepatic biosynthesis and catabolism of ubiquinone.
The effect of p-chlorophenoxyisobutyrate (CPIB) feeding on cholesterol and ubiquinone metabolism in rats was investigated. The results obtained from acetate-1-(14)C and mevalonate-2-(14)C incorporation studies both in vivo and in vitro confirm the results of other workers that CPIB feeding caused a metabolic block in the conversion of acetate to mevalonate, thereby inhibiting over-all steroidogenesis. Liver ubiquinone synthesis was inhibited in CPIB-fed rats, but a block in the catabolism of the ubiquinone resulted in accumulation of ubiquinone in CPIB-fed animals.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002087:Butyrates / Q000494:pharmacology*; D002247:Carbon Isotopes; D002713:Chlorine; D002784:Cholesterol / Q000096:biosynthesis*; D006838:Hydrocarbons / Q000096:biosynthesis; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008798:Mevalonic Acid / Q000378:metabolism; D051381:Rats; D013261:Sterols / Q000096:biosynthesis; D014451:Ubiquinone / Q000096:biosynthesis*
D000085:Acetates; D000924:Anticholesteremic Agents; D002087:Butyrates; D002247:Carbon Isotopes; D006838:Hydrocarbons; D013261:Sterols; D014451:Ubiquinone; D002713:Chlorine; D002784:Cholesterol; D008798:Mevalonic Acid