Evidence that central nervous system depression by 1,4-butanediol in mediated through a metabolite, gamma-hydroxybutyrate.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002490:Central Nervous System / Q000187:drug effects; D002849:Chromatography, Gas; D006018:Glycols / Q000378:metabolism / Q000494:pharmacology*; D006885:Hydroxybutyrates / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D007783:Lactones / Q000378:metabolism; D008954:Models, Biological; D009949:Orientation / Q000187:drug effects; D051381:Rats; D012890:Sleep
D006018:Glycols; D006885:Hydroxybutyrates; D007783:Lactones