Regulation of pentitol metabolism by Aerobacter aerogenes. I. Coordinate control of ribitol dehydrogenase and D-ribulokinase activities.
Induction studies on Aerobacter aerogenes strain PRL-R3, using ribitol as the inducer-substrate, indicated that two enzymes of ribitol catabolism, ribitol dehydrogenase and d-ribulokinase, are coordinately induced. The utilization of d-arabinose as a substrate resulted in the induction of ribitol dehydrogenase as well as d-ribulokinase. Mutants which were constitutive for ribitol dehydrogenase were also constitutive for d-ribulokinase. In contrast, d-xylulokinase and d-arabitol dehydrogenase did not appear to be coordinately controlled. Induction studies and examination of d-arabitol dehydrogenase constitutive mutants indicated that the three enzymes of the converging pathways for d-arabitol and d-xylose catabolism are under separate control.
D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000438:Alcohols / Q000378:metabolism*; D004754:Enterobacter / Q000201:enzymology / Q000378:metabolism*; D004790:Enzyme Induction; D004794:Enzyme Repression; D008967:Molecular Biology; D009154:Mutation; D010770:Phosphotransferases / Q000378:metabolism*; D014994:Xylose / Q000378:metabolism
D000438:Alcohols; D014994:Xylose; D000429:Alcohol Oxidoreductases; D010770:Phosphotransferases