The metabolism of S-methyl-L-cysteine.
1. Methylsulphinylacetic acid, 2-hydroxy-3-methylsulphinylpropionic acid and methylmercapturic acid sulphoxide (N-acetyl-S-methyl-l-cysteine S-oxide) were isolated as their dicyclohexylammonium salts from the urine of rats after they had been dosed with S-methyl-l-cysteine. 2. A fourth sulphoxide was isolated but not identified. 3. The excretion of sulphate in the urine of rats dosed with S-methyl-l-cysteine was measured. 4. The metabolism of S-methyl-l-cysteine by the hamster and guinea pig was examined chromatographically. 5. The preparation of the following compounds is reported: (-)-dicyclohexylammonium methyl-mercapturate sulphoxide; the dicyclohexylammonium salts of the optically inactive forms of 2-hydroxy-3-methylthiopropionic acid, 2-hydroxy-3-methyl-sulphinylpropionic acid and methylsulphinylacetic acid.
D000818:Animals; D002854:Chromatography, Paper; D006224:Cricetinae; D003545:Cysteine / Q000378:metabolism*; D006168:Guinea Pigs; D007259:Infrared Rays; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D013053:Spectrophotometry; D013431:Sulfates / Q000652:urine; D013454:Sulfoxides / Q000138:chemical synthesis / Q000652:urine*; D013460:Sulfur Isotopes
D013431:Sulfates; D013454:Sulfoxides; D013460:Sulfur Isotopes; D003545:Cysteine