Virus-induced hemolysis in erythrocytes deficient in glucose-6-phhosphate dehydrogenase.
Red cells from individuals deficient in glucose-6-phosphate dehydrogenase undergo increased autohemolysis when incubated in the presence of influenza-A virus. Normal red cells, but not those from individuals deficient in glucose-6-phosphate dehydrogenase, show increased activity of the hexose monophosphate shunt in the presence of the virus. This increase in shunt activity appears to be related to oxidation of cellular sulfhydryl groups.
D002247:Carbon Isotopes; D003588:Cytopathogenic Effect, Viral; D004912:Erythrocytes / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000378:metabolism; D006366:Heinz Bodies; D006461:Hemolysis; D006600:Hexosephosphates / Q000378:metabolism; D006801:Humans; D009975:Orthomyxoviridae / Q000472:pathogenicity*; D013438:Sulfhydryl Compounds / Q000378:metabolism; D014774:Virulence
D002247:Carbon Isotopes; D006600:Hexosephosphates; D013438:Sulfhydryl Compounds; D005947:Glucose