The phosphaturic effect of sodium bicarbonate and acetazolamide in dogs.
Urinary inorganic phosphate excretion was studied before and during the administration of sodium bicarbonate and acetazolamide in dogs that were not given infusions of phosphate. The excretion fraction of filtered phosphate increased after sodium bicarbonate or acetazolamide was given. This phosphaturia was attributed to decreased tubular reabsorption of phosphate consequent to alkalinization of either tubular urine or cells.
D000086:Acetazolamide / Q000494:pharmacology*; D000478:Alkylation; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D007684:Kidney Tubules / Q000378:metabolism*; D010710:Phosphates / Q000652:urine*; D012964:Sodium / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology
D001639:Bicarbonates; D010710:Phosphates; D012965:Sodium Chloride; D012964:Sodium; D000086:Acetazolamide