Desmosine biosynthesis: nature of inhibition by D-penicillamine.
Administration of D-penicillamine and lathyrogens such as beta-amino-propionitrile to animals markedly alters connective tissue by preventing the normal cross-linkage of elastin and collagen. It had been shown that beta-aminopropionitrile blocks the cross-linkage of elastin and collagen by preventing the initial step in cross-linkage: the conversion of lysine in peptide linkage to alpha-amino adipic-delta-semialdehyde. We show that penicillamine acts after the initial step, causing the accumulation of an elastin rich in alpha-amino adipic-delta-semialdehyde.
D000272:Adipates; D000596:Amino Acids / Q000096:biosynthesis*; D000629:Aminopropionitrile / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000032:analysis / Q000196:embryology; D002642:Chick Embryo / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism*; D003864:Depression, Chemical; D004549:Elastin / Q000378:metabolism*; D007842:Lathyrism / Q000378:metabolism; D008239:Lysine; D010396:Penicillamine / Q000494:pharmacology*; D010452:Peptide Biosynthesis
D000272:Adipates; D000596:Amino Acids; D000629:Aminopropionitrile; D003094:Collagen; D004549:Elastin; D010396:Penicillamine; D008239:Lysine