Antagonism of reserpine-induced emesis in pigeons: a screening method for antidepressant activity.
1. Various antidepressant drugs and procedures have been studied against reserpine-induced emesis in pigeons.2. Electroconvulsions, pentylenetetrazol and a non-hydrazide monoamine oxidase inhibitor (pargyline) block reserpine emesis.3. It is suggested that reserpine-induced emesis in pigeons provides a simple and reliable method for studying anti-reserpine activity, and the compounds effective in antagonizing this emetic response are likely to have antidepressant property.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D010856:Columbidae; D004597:Electroshock; D007328:Insulin / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology; D012110:Reserpine / Q000037:antagonists & inhibitors*; D014839:Vomiting / Q000139:chemically induced*
D000928:Antidepressive Agents; D007328:Insulin; D008996:Monoamine Oxidase Inhibitors; D012110:Reserpine; D010293:Pargyline; D010433:Pentylenetetrazole