The effects of a thiamine antagonist, pyrithiamine, on levels of selected metabolic intermediates and on activities of thiamine-dependent enzymes in brain and liver.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry / Q000187:drug effects*; D005942:Gluconates / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D005977:Glutarates / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000032:analysis / Q000187:drug effects* / Q000201:enzymology*; D051379:Mice; D010088:Oxidoreductases / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D013831:Thiamine / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D014020:Tissue Extracts; D014166:Transferases / Q000378:metabolism
D005942:Gluconates; D005971:Glutamates; D005977:Glutarates; D007773:Lactates; D011773:Pyruvates; D014020:Tissue Extracts; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D006003:Glycogen; D010088:Oxidoreductases; D014166:Transferases; D005947:Glucose; D013831:Thiamine