Mode of spirolactone action: competitive inhibition of aldosterone binding to kidney mineralocorticoid receptors.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003864:Depression, Chemical; D007668:Kidney / Q000166:cytology / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D051381:Rats; D011955:Receptors, Drug; D013148:Spironolactone / Q000494:pharmacology*; D014316:Tritium
D011955:Receptors, Drug; D014316:Tritium; D013148:Spironolactone; D000450:Aldosterone