Liver adenine nucleotides: fructose-induced depletion and its effect on protein synthesis.
Intravenous administration of D-fructose to rats rapidly depletes liver adenosine triphosphate and inorganic phosphate; marked elevations of uric acid and allantoin in plasma follow. Concomitantly the incorporation of DL-leucine-1-(14)C into liver protein is almost completely inhibited.
D000227:Adenine Nucleotides / Q000032:analysis; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000481:Allantoin / Q000097:blood; D000818:Animals; D002239:Carbohydrate Metabolism, Inborn Errors; D002247:Carbon Isotopes; D003864:Depression, Chemical; D005632:Fructose / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D014176:Protein Biosynthesis; D051381:Rats; D013237:Stereoisomerism; D014527:Uric Acid / Q000097:blood
D000227:Adenine Nucleotides; D002247:Carbon Isotopes; D010710:Phosphates; D014527:Uric Acid; D005632:Fructose; D000481:Allantoin; D000255:Adenosine Triphosphate; D007930:Leucine