Erythropoiesis in the rat: differential rates of DNA synthesis and cell proliferation.
Direct in vivo estimates of DNA synthesis time in early and late erythroblasts were obtained by using the H(3)- and C(14)-thymidine double-la-beling technique. A double-emulsion autoradiographic procedure was used to resolve the two isotopes. Early erythroblasts were found to proliferate at a rate about five times that of late cells. This results primarily from a shorter mean DNA synthesis time in early cells (2.5 hours) than in late cells (6.5 hours).
D000818:Animals; D001345:Autoradiography; D001854:Bone Marrow Cells; D002247:Carbon Isotopes; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis*; D004912:Erythrocytes; D004920:Erythropoiesis; D008297:Male; D008954:Models, Biological; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D002247:Carbon Isotopes; D014316:Tritium; D004247:DNA; D013936:Thymidine