Counteraction of platelet activity at sites of laser-induced endothelial trauma.
The effects of dextran 70 (Mw 70,000; Macrodex), heparin, dipyridamole (Persantin), and prostaglandin E(1) on the behaviour of platelets were investigated at sites of endothelial trauma induced with a ruby biolaser in arterioles in the rabbit ear chamber. This technique has several advantages over previous methods of studying platelet activity.Dextran 70 (2 g./kg. body weight) caused a profound reduction in platelet activity four to six hours after its administration. Heparin (12 mg./kg. body weight) had no effect. The effect of dipyridamole (2.5 mg./kg. body weight) was profound immediately after its administration, but was transient. In preliminary experiments single intravenous injections of prostaglandin E(1) (25 and 125 mug./kg. body weight) had no detectable effect.
D000818:Animals; D001158:Arteries / Q000293:injuries*; D001792:Blood Platelets / Q000187:drug effects*; D003864:Depression, Chemical; D003911:Dextrans / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D004431:Ear, External / Q000293:injuries*; D006493:Heparin / Q000494:pharmacology; D007834:Lasers; D011453:Prostaglandins / Q000494:pharmacology; D011817:Rabbits; D013927:Thrombosis / Q000209:etiology*; D013997:Time Factors
D003911:Dextrans; D011453:Prostaglandins; D004176:Dipyridamole; D006493:Heparin