Hemin: an inhibitor of erythroid cell ribonuclease.
Hemin, in concentrations which stimulate protein synthesis and stabilize polyribosomes in reticulocytes, is a potent inhibitor of ribonuclease activity in the erythroid cell. This may offer a partial explanation for the way in which hemin acts to accelerate globin synthesis and thus synchronize the synthesis of hemin and globin in the maturing erythroid cell.
D000818:Animals; D003864:Depression, Chemical; D005914:Globins / Q000096:biosynthesis; D006418:Heme / Q000494:pharmacology*; D008566:Membranes / Q000201:enzymology; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects / Q000201:enzymology*; D012260:Ribonucleases / Q000037:antagonists & inhibitors* / Q000097:blood
D006418:Heme; D005914:Globins; D012260:Ribonucleases