Annulment of sterol-induced sexual reproduction by estradiol in Pythium periplocum.
Estradiol prevented cholesterol-induced sexual reproduction by the fungus Pythium periplocum. Inhibition by estradiol was partial at 10-(6)M and complete at 10-(5)M, the same concentrations at which cholesterol and beta-sitosterol were initially and maximally active. Higher concentrations of estradiol were required for growth inhibition than for inhibition of reproduction.
D000924:Anticholesteremic Agents; D003864:Depression, Chemical; D004958:Estradiol / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects / Q000254:growth & development*; D012098:Reproduction / Q000187:drug effects*; D012737:Sex Factors; D013170:Spores; D013261:Sterols / Q000037:antagonists & inhibitors*
D000924:Anticholesteremic Agents; D013261:Sterols; D004958:Estradiol