Evoked release of norepinephrine and serotonin from brain slices: inhibitoon by lithium.
Slices of mammalian brain accumulate H(3)-norepinephrine and H(3)-serotonin when incubated in a physiologic medium containing these tritiated monoamines. When these tissues are subjected to mild electrical stimulation of short duration, which is associated with depolarization of nerve membranes, a striking increase in the rate of efflux of the exogenous labeled monoamines occurs. Stimulation-induced release of both labeled monoamines is diminished by the presence of lithium ions in the perfusing medium; related monovalent cations had no such effect. Evoked release from slices of brain from animals treated intraperitoneally with lithium chloride for 3 days was also reduced.
D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003470:Culture Media; D046508:Culture Techniques; D003864:Depression, Chemical; D004558:Electric Stimulation; D008094:Lithium / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014316:Tritium
D003470:Culture Media; D014316:Tritium; D012701:Serotonin; D008094:Lithium; D009638:Norepinephrine