The effect of 2,4-dinitrophenol and related compounds on bile secretion.
1. 2,4-dinitrophenol, 2,4-dinitrophenetole, 2,4-dinitronaphthol, 4,6-dinitro-o-cresol, and to a lesser extent picric acid, produced an increase in bile flow and a rise in body temperature in the anaesthetized dog. The total biliary bromsulphalein (BSP) excretion in unit time was either slightly reduced, increased or remained at its pre-injection level.2. Picramic acid, the nitrochlorophenols and 2,4-dinitrobenzaldehyde caused a moderate increase in bile flow without an effect on the temperature of the animal.3. The three mononitrophenols, the five remaining isomeric dinitrophenols, isopicramic acid, the aminonitrophenols, phenol, 2,4-dinitroanisole, 2,4-dinitrobenzoic acid, 2,4-dinitrobenzene sulphonic acid, 2,4-dinitroresorcinol and 4-nitracatechol had little effect on bile secretion or body temperature.4. It thus appears that, in order for a compound of this type to have a pronounced effect on bile secretion, it is necessary to have nitro groups in positions 2 and 4 of the benzene ring, and a free or potential hydroxyl group.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D002756:Cholagogues and Choleretics; D004140:Dinitrophenols / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D008099:Liver / Q000187:drug effects*; D008297:Male; D009596:Nitrophenols / Q000494:pharmacology; D010851:Picrates / Q000494:pharmacology; D013448:Sulfobromophthalein / Q000378:metabolism
D002756:Cholagogues and Choleretics; D004140:Dinitrophenols; D009596:Nitrophenols; D010851:Picrates; D013448:Sulfobromophthalein