Trimethoprim and sulphamethoxazole in typhoid.
Six patients with proved typhoid fever were treated with a combination of trimethoprim and sulphamethoxazole; four others were treated with chloramphenicol. All ten patients made an uneventful recovery.Though the numbers are small it appears that the patients treated with the combined drugs did just as well as those treated with chloramphenicol, and fever seemed to subside quicker with the combined drugs.Trimethoprim and sulphamethoxazole have low toxicities, so further studies of their use in the treatment of typhoid are justified.
D000293:Adolescent; D000328:Adult; D002648:Child; D002701:Chloramphenicol / Q000627:therapeutic use; D004357:Drug Synergism; D005260:Female; D005334:Fever / Q000188:drug therapy; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014435:Typhoid Fever / Q000188:drug therapy*
D005493:Folic Acid Antagonists; D011743:Pyrimidines; D002701:Chloramphenicol; D013420:Sulfamethoxazole