Binding of neomycin and analogues by fatty acids in vitro.
Neomycin forms insoluble complexes with long-chain fatty acids in vitro. This reduces the diffusion of neomycin but does not directly neutralize its antibiotic activity. Possible effects in vivo are discussed.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D004058:Diffusion; D004352:Drug Resistance, Microbial; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D009355:Neomycin / Q000378:metabolism / Q000627:therapeutic use; D013210:Staphylococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D009355:Neomycin