Accelerated purine biosynthesis de novo in skin fibroblasts deficient in hypoxanthine--guanine phosphoribosyltransferase activity.
D000225:Adenine / Q000378:metabolism / Q000494:pharmacology; D000227:Adenine Nucleotides / Q000096:biosynthesis; D002247:Carbon Isotopes; D003864:Depression, Chemical; D004912:Erythrocytes / Q000201:enzymology; D005246:Feedback; D005347:Fibroblasts / Q000378:metabolism*; D005561:Formates / Q000378:metabolism; D006147:Guanine / Q000494:pharmacology; D006801:Humans; D007042:Hypoxanthines / Q000096:biosynthesis / Q000494:pharmacology; D015122:Mercaptopurine / Q000494:pharmacology; D008659:Metabolic Diseases / Q000201:enzymology*; D009705:Nucleosides / Q000096:biosynthesis; D011687:Purines / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism*; D013268:Stimulation, Chemical; D014166:Transferases; D014316:Tritium
D000227:Adenine Nucleotides; D002247:Carbon Isotopes; D005561:Formates; D007042:Hypoxanthines; D009705:Nucleosides; D011687:Purines; D014316:Tritium; D006147:Guanine; D015122:Mercaptopurine; D014166:Transferases; D000225:Adenine