Noncycling tumor cells: mitogenic response to antilymphocytic serum.
After continuous labeling with tritiated thymidine for a period several times the cell generation time, some ELD ascites cells remained unlabeled. Despite continued exposure to tritiated thymidine, unlabeled mitoses appeared promptly after administration of mouse antilymphocytic serum. Immunosuppression released some noncycling G(2) tumor cells into mitosis.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001345:Autoradiography; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology*; D004273:DNA, Neoplasm / Q000032:analysis; D007106:Immune Sera / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008938:Mitosis; D010783:Photometry; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D000961:Antilymphocyte Serum; D004273:DNA, Neoplasm; D007106:Immune Sera; D007166:Immunosuppressive Agents; D014316:Tritium; D013936:Thymidine