Estrogenic activity of o,p'-DDT in the mammalian uterus and avian oviduct.
When rats and birds were treated with o, p-DDT, their reproductive tissues exhibited the same response as when they were treated with estrogen. Weight, water content, glycogen, and RNA increased in uteri and oviducts of rats, chickens, and quail receiving o, p-DDT; p, p-DDT produced little if any response. The o, p-DDT did not accumulate in the reproductive or adipose tissues to a greater extent than p, p-DDT.
D000818:Animals; D002645:Chickens; D002849:Chromatography, Gas; D003634:DDT / Q000378:metabolism / Q000494:pharmacology*; D004463:Ecology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006003:Glycogen / Q000032:analysis; D009929:Organ Size; D010057:Oviducts / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D011200:Poultry; D011874:Radiometry; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013237:Stereoisomerism; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D004958:Estradiol; D006003:Glycogen; D003634:DDT