The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system.
1. Experiments were carried out to determine whether the prostaglandins, which have been identified as natural constituents of the brain, are widely distributed or concentrated in special regions of the central nervous system.2. Prostaglandins E(1), E(2), F(1alpha) and F(2alpha) have been identified in dog brain using solvent partition, column and thin layer chromatographic and bio-assay techniques.3. Each of these prostaglandins is distributed throughout all regions of the central nervous system investigated (cortex, hippocampus, caudate nucleus, hypothalamus, cerebellum, medulla and pons, cortical white matter and spinal cord).4. This distribution suggests that the role of prostaglandins in the central nervous system is not confined to any specific region.
D000818:Animals; D001681:Biological Assay; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000032:analysis; D002490:Central Nervous System / Q000378:metabolism*; D002531:Cerebellum / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006624:Hippocampus / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis; D007082:Ileum / Q000187:drug effects; D007583:Jejunum / Q000187:drug effects; D008526:Medulla Oblongata / Q000032:analysis; D009130:Muscle, Smooth / Q000187:drug effects; D011149:Pons / Q000032:analysis; D011453:Prostaglandins / Q000032:analysis*; D011817:Rabbits; D051381:Rats; D013116:Spinal Cord / Q000032:analysis; D013270:Stomach / Q000187:drug effects; D014316:Tritium; D014599:Uterus / Q000187:drug effects
D011453:Prostaglandins; D014316:Tritium