Complete suppression of haemoglobin A synthesis in haemoglobin D Los Angeles--beta thalassaemia.
A family study is reported in which all three siblings were shown to be doubly heterozygous for haemoglobin D Los Angeles and beta thalassaemia, which resulted in a complete suppression of haemoglobin A synthesis. This demonstrates the effects of genetic interaction which occur when the genes for haemoglobin D Los Angeles and beta thalassaemia are both transmitted to the offspring. The importance of family studies in the investigation of haemoglobin abnormalities is stressed.
D000293:Adolescent; D000328:Adult; D005260:Female; D006454:Hemoglobins / Q000096:biosynthesis; D006455:Hemoglobins, Abnormal / Q000096:biosynthesis*; D006579:Heterozygote; D006801:Humans; D007194:India; D008297:Male; D013789:Thalassemia / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D044465:White People
D006454:Hemoglobins; D006455:Hemoglobins, Abnormal