Reversal of folate malabsorption in tropical and non-tropical sprue by calf jejunum.
In eight patients with folic acid malabsorption the malabsorption was reversed only when a combination of either 250 mg. of lyophilized human jejunal juice or 5 g. of lyophilized calf jejunum with 5 mg. of synthetic folic acid was fed; calf liver was ineffective. The factors in calf jejunum that re-established folic acid absorption were heat-stable and did not form polyglutamyl folates on previous incubation with folic acid.
D000818:Animals; D002417:Cattle; D002446:Celiac Disease / Q000188:drug therapy*; D005492:Folic Acid / Q000097:blood / Q000378:metabolism*; D005494:Folic Acid Deficiency / Q000188:drug therapy; D006801:Humans; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism; D013182:Sprue, Tropical / Q000188:drug therapy; D014020:Tissue Extracts / Q000627:therapeutic use*
D014020:Tissue Extracts; D005492:Folic Acid