Deamino-oxytocin: inactivation  plasma of women in labor.
Incubation of deamino-oxytocin with plasma obtained from women in labor reduced the potency of this analog of oxytocin when assayed on an isolated strip of mammary gland taken from a lactating rat. Plasmas of nonpregnant women had no detectable effect on this activity of deamino-oxytocin, and the effect of plasmas from women just previous to the beginning of labor was not significant. The original. activities of the incubated deamino-oxytocin solutions could be restored by treatment with hydrogen peroxide. The inactivation may be caused by reductive cleavage of the disulfide bridge of deamino-oxytocin, this bridge being reformed by oxidation.
D000818:Animals; D001681:Biological Assay; D001769:Blood; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide; D066298:In Vitro Techniques; D007743:Labor, Obstetric; D007774:Lactation; D008321:Mammary Glands, Animal / Q000187:drug effects; D010120:Oxytocics / Q000032:analysis*; D010121:Oxytocin; D011247:Pregnancy; D051381:Rats; D013440:Sulfides
D010120:Oxytocics; D013440:Sulfides; D010121:Oxytocin; D006861:Hydrogen Peroxide