Intravenous iron-dextran: studies on unsaturated iron-binding capacity.
A method is described for measuring the plasma unsaturated iron-binding capacity in the presence of very high concentrations of iron as iron-dextran. The procedure utilizes (59)Fe to label the apotransferrin with subsequent separation of ionic iron from transferrin-bound iron on an ion exchange or Sephadex G.25 column. The unsaturated iron-binding capacity has been measured in rabbits and dogs after intravenous injection of iron-dextran and in human subjects after total dose infusion of iron-dextran. No evidence of saturation of the unsaturated iron-binding capacity was found even when the plasma iron values were greater than 40,000 mug Fe/100 ml.
D000818:Animals; D004285:Dogs; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007501:Iron / Q000097:blood*; D007503:Iron Isotopes; D007505:Iron-Dextran Complex; D011247:Pregnancy; D011485:Protein Binding; D011817:Rabbits
D007503:Iron Isotopes; D007505:Iron-Dextran Complex; D007501:Iron