Sterol precursors of cholesterol in adult human brain.
Adult human brain contains cholestanol and two series of cholesterol precursors having 30, 29, 28, and 27 carbon atoms; one has an unsaturated steroid nucleus, and the other is unsaturated in both nucleus and side chain. The ability of preparations of brain to incorporate a specific precursor into cholesterol, as well as into these sterol metabolites in vitro, indicates that cholesterol synthesis continues long after brain maturation ceases.
D000328:Adult; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002247:Carbon Isotopes; D002776:Cholestanes / Q000032:analysis / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis*; D002849:Chromatography, Gas; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery; D008798:Mevalonic Acid / Q000378:metabolism; D013261:Sterols / Q000032:analysis / Q000378:metabolism*
D002247:Carbon Isotopes; D002776:Cholestanes; D013261:Sterols; D002784:Cholesterol; D008798:Mevalonic Acid