Effects of a single oral load of medium-chain triglyceride on serum lipid and insulin levels in man.
Analysis of serum free fatty acids by gas-liquid chromatography showed high proportions (27-57%) of octanoic acid for up to 4 hr after the ingestion of a single oral load of medium-chain triglyceride (approximately 1 g/kg body weight) in four volunteers. The effects of a medium-chain triglyceride load on the concentrations of plasma free long-chain fatty acids, plasma glucose, serum insulin, and serum triglyceride were observed and compared with the effects of a glucose load. A rapid fall in the free long-chain fatty acids followed both loads but only a small rise in serum insulin was observed after medium-chain triglyceride. The fall in free long-chain fatty acids following ingestion of medium-chain triglyceride cannot therefore be caused mainly by the release of insulin and may be due to a direct action on adipose tissue. No medium-chain fatty acids were detected in the serum triglyceride after ingestion of medium-chain triglyceride, but there was a small but significant increase in the percentage of hexadecenoic acid in this fraction.
D000328:Adult; D001786:Blood Glucose; D002648:Child; D003864:Depression, Chemical; D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified / Q000032:analysis / Q000097:blood*; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D013268:Stimulation, Chemical; D013997:Time Factors; D014280:Triglycerides / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D005947:Glucose; D005990:Glycerol