Inactivating and mutagenic effects of 1-methyl-3-nitro-1-nitrosoguanidine on intracellular bacteriophage.
1-Methyl-3-nitro-1-nitrosoguanidine (NG) was able to inactivate and mutate adsorbed but not free coliphage T2. Coliphage T4 was as sensitive to NG as T2. When treatment was delayed for 5 min or longer after adsorption of T2, the phage became increasingly refractory to NG inactivation.
D000327:Adsorption; D003090:Coliphages / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009603:Nitroso Compounds / Q000494:pharmacology*
D006146:Guanidines; D009153:Mutagens; D009603:Nitroso Compounds