The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism.
D001205:Ascorbic Acid / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D004357:Drug Synergism; D004912:Erythrocytes / Q000378:metabolism; D005236:Favism; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D010100:Oxygen; D011743:Pyrimidines / Q000494:pharmacology*; D013057:Spectrum Analysis; D014466:Ultraviolet Rays
D011743:Pyrimidines; D004295:Dihydroxyphenylalanine; D005978:Glutathione; D001205:Ascorbic Acid; D010100:Oxygen