Effects of prostaglandins E1 and E2 on human, guinea-pig and rat isolated small intestine.
1. Prostaglandins E(1) and E(2) contracted the longitudinal muscle of human, guinea-pig and rat isolated ileum.2. The site of action varied with the species. In the rat and in some strips of human tissue prostaglandin appeared to have only a direct action on or in the muscle cells. In the other strips of human tissue and in guinea-pig ileum the prostaglandins seemed to stimulate both the intrinsic cholinergic nerves and the muscle cells.3. In contrast to the longitudinal muscle, the circular muscle of human, guinea-pig and rat isolated ileum was usually inhibited by prostaglandin, apparently by an action directly on the muscle cells.4. Prostaglandins may play a part in the control of intestinal motility.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D005769:Gastrointestinal Motility; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006801:Humans; D007082:Ileum / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013045:Species Specificity; D013779:Tetrodotoxin / Q000494:pharmacology
D006584:Hexamethonium Compounds; D011453:Prostaglandins; D013779:Tetrodotoxin; D012601:Scopolamine; D000109:Acetylcholine