Warfarin treatment of mice bearing autochthonous tumors: effect on spontaneous metastases.
Long-term oral administration of sodium warfarin significantly reduced the incidence of spontaneous metastases in the lungs from 83 percent in controls to 8 percent in treated C57/BL/6N mice. The size and weight of primary tumors in mice treated with warfarin were less than in control mice. Length of survival was unaffected.
D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced; D008748:Methylcholanthrene; D051379:Mice; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000401:mortality; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D014859:Warfarin / Q000494:pharmacology* / Q000627:therapeutic use
D008748:Methylcholanthrene; D014859:Warfarin