Preparation, properties and metabolism of 5,6-monoepoxy-3-dehydroretinal.
1. 5,6-Monoepoxy-3-dehydroretinal was synthesized from 3-dehydroretinyl acetate and characterized. 2. When fed to vitamin A-deficient rats, 5,6-monoepoxy-3-dehydroretinal was converted into 5,6-monoepoxy-3-dehydrovitamin A and stored in the liver. 3. It was demonstrated that the rat possesses the necessary enzymes for the reduction and oxidation of 5,6-monoepoxy-3-dehydroretinal to the corresponding alcohol and acid respectively. 4. The biological potency of the epoxy-3-dehydroretinal by the rat-growth assay (determined by USP XIV procedure) was 1.07% of that of vitamin A.
D000429:Alcohol Oxidoreductases / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D006128:Growth / Q000187:drug effects; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D010088:Oxidoreductases / Q000032:analysis; D051381:Rats; D014801:Vitamin A / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D014802:Vitamin A Deficiency / Q000378:metabolism
D014801:Vitamin A; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases