Irreversible enzyme inhibitors. 143. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenoxypropyl)-2,4-diamino-6-methylpyrimidine with a terminal sulfonyl fluoride.
D000818:Animals; D001555:Benzene Derivatives; D001665:Binding Sites; D002219:Carbamates; D055598:Chemical Phenomena; D002621:Chemistry; D046508:Culture Techniques; D005459:Fluorides; D005493:Folic Acid Antagonists; D007422:Intestines / Q000201:enzymology; D007939:Leukemia L1210 / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis; D013154:Spleen / Q000201:enzymology; D013451:Sulfonic Acids / Q000138:chemical synthesis
D001555:Benzene Derivatives; D002219:Carbamates; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D013451:Sulfonic Acids; D005459:Fluorides