Hemicholinium-3: noncholinergic effects on squid axons.
Hemicholinium-3, when applied to the inside of a squid axon, is effective in blocking the action potential. This action is not antagonized by the addition of choline or acetylcholine to the perfusate. Voltage-clamp experiments show that hemicholinium-3 depresses both the early transient and late steady-state components of membrane ionic conductances, with a greater effect on the peak transient component.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001369:Axons / Q000187:drug effects*; D002794:Choline / Q000494:pharmacology; D066298:In Vitro Techniques; D008566:Membranes / Q000187:drug effects; D008974:Mollusca; D010276:Parasympatholytics / Q000494:pharmacology*; D010477:Perfusion
D010276:Parasympatholytics; D002794:Choline; D000109:Acetylcholine