Action of a pyrimido-pyrimidine compound on platelet behaviour in vitro.
A pyrimido-pyrimidine compound (RA433) was found in vitro to be a significantly more potent inhibitor of platelet behaviour than the previously available pyrimido-pyrimidine compound RA8-dipyridamole. In a turbidimetric system RA433 inhibits platelet aggregation induced by adenosine diphosphate, collagen, and noradrenaline; further, in a glass-bead-column technique it is a powerful inhiitor of platelet adhesiveness.
D000227:Adenine Nucleotides; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects*; D003094:Collagen; D003864:Depression, Chemical; D004176:Dipyridamole / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009025:Morpholines / Q000494:pharmacology*; D009638:Norepinephrine; D011743:Pyrimidines / Q000494:pharmacology*
D000227:Adenine Nucleotides; D009025:Morpholines; D011743:Pyrimidines; D004176:Dipyridamole; D003094:Collagen; D009638:Norepinephrine