Acetazolamide and sodium bicarbonate in treatment of salicylate poisoning in adults.
Ten adults suffering from salicylate overdosage were treated successfully with a combination of sodium bicarbonate and acetazolamide to exploit the increase in salicylate clearance which is known to occur in very alkaline urine. The advantages of the method include the absence of important complications and the small volume of fluid required.
D000086:Acetazolamide / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D001639:Bicarbonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D006435:Renal Dialysis; D012459:Salicylates / Q000097:blood / Q000378:metabolism / Q000506:poisoning* / Q000652:urine; D012964:Sodium / Q000627:therapeutic use
D001639:Bicarbonates; D012459:Salicylates; D012964:Sodium; D000086:Acetazolamide