Further study into obstructive jaundice and ischaemic renal damage.
Renal ischaemia for one hour in two groups of Gunn rats, one with and the other without bile-duct ligation, produced comparable reversible renal tubular lesions in both groups. Since Gunn rats have an unconjugated hyperbilirubinaemia, which is unaffected by bile-duct ligation, it seems likely that the high levels of bilirubin glucuronide are responsible for sensitizing the renal tubules to ischaemia, possibly by depressing cell respiration.
D058186:Acute Kidney Injury / Q000209:etiology*; D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D001652:Bile Ducts / Q000502:physiology; D001663:Bilirubin / Q000032:analysis; D001806:Blood Urea Nitrogen; D002779:Cholestasis / Q000150:complications*; D006932:Hyperbilirubinemia; D007511:Ischemia; D007668:Kidney / Q000032:analysis / Q000378:metabolism / Q000473:pathology; D051381:Rats
D001647:Bile Acids and Salts; D001663:Bilirubin