[Chloroplast ribosomes: stereospecificity of inhibition by chloramphenicol].
Chloroplast ribosomes from tobacco leaves show the same stereospecificity of inhibition by chloramphenicol as bacterial ribosomes do. Cytoplasmic ribosomes from the same leaves are unaffected by chloramphenicol. These results remove doubts raised by nonstereospecific effects of chloramphenicol on higher plant cells and support the concept that chloroplasts have evolved from prokaryotes.
D002247:Carbon Isotopes; D002701:Chloramphenicol / Q000494:pharmacology*; D002736:Chloroplasts / Q000187:drug effects* / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D003864:Depression, Chemical; D007930:Leucine / Q000378:metabolism; D010940:Plant Proteins / Q000096:biosynthesis; D010947:Plants, Toxic; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism; D012995:Solubility; D013237:Stereoisomerism; D013501:Surface-Active Agents; D014026:Nicotiana / Q000166:cytology
D002247:Carbon Isotopes; D010940:Plant Proteins; D013501:Surface-Active Agents; D002701:Chloramphenicol; D003513:Cycloheximide; D007930:Leucine