Plasminogen-activator-producing tumour.
In a patient with giant-cell carcinoma of the lung a secondary tumour deposit in the arm was incised and bled for three weeks. Investigations showed the tumour to be rich in plasminogen activator. Haemostasis in the tumour was achieved with aminocaproic acid therapy. For a period the plasminogen-activator properties were retained in cell culture of the tumour.
D000368:Aged; D000614:Aminocaproates / Q000627:therapeutic use; D001132:Arm; D002277:Carcinoma / Q000378:metabolism*; D046508:Culture Techniques; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D009362:Neoplasm Metastasis; D010958:Plasminogen / Q000378:metabolism*
D000614:Aminocaproates; D010958:Plasminogen