The relationship between tremor and change in brain acetylcholine concentration produced by injection of tremorine or oxotremorine in the rat.
1. The relationship between tremor and change in brain acetylcholine concentration after the injection of tremorine or oxotremorine has been investigated in rats.2. Tremorine produced a significant increase in whole brain acetylcholine and in tremor 5 min after injection. After this time tremor subsided but brain acetylcholine continued to increase.3. Oxotremorine produced tremor within 30 sec. This became maximal within 5 min of injection and then declined rapidly. The brain acetylcholine concentration showed a significant increase 5 min after injection and continued to increase until 30 min afterwards.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D008297:Male; D011759:Pyrrolidines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced*; D014203:Tremorine / Q000008:administration & dosage / Q000494:pharmacology*
D011759:Pyrrolidines; D000109:Acetylcholine; D014203:Tremorine