Calciphylaxis in man.
A patient with renal failure developed widespread calcification in the thighs after the injection of iron-dextran (Imferon). This is considered as an example of calciphylaxis, a process in which calcium is laid down in parts of the body following the administration of a "challenger." Iron-dextran is a known challenger, and should be used with caution in uraemic subjects, who may be sensitized by high serum parathyroid hormone levels. Contributing factors may have been a high calcium/phosphate product, steroids, and the patient's immobility.
D000328:Adult; D002115:Calciphylaxis; D002130:Calcium Phosphates / Q000097:blood; D006801:Humans; D007505:Iron-Dextran Complex / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D008297:Male; D009277:Nandrolone / Q000627:therapeutic use; D010281:Parathyroid Hormone / Q000097:blood; D011241:Prednisone / Q000009:adverse effects; D011859:Radiography; D013848:Thigh / Q000000981:diagnostic imaging / Q000473:pathology; D014511:Uremia / Q000188:drug therapy
D002130:Calcium Phosphates; D010281:Parathyroid Hormone; D009277:Nandrolone; D007505:Iron-Dextran Complex; D011241:Prednisone