Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type.
The immune responses of inbred mice to a related series of three synthetic polypeptide antigens are genetically controlled traits which are closely correlated with the genotype for the major histocompatibility (H-2) locus. All strains of the same H-2 type exhibit the same pattern of immune response, independent of the remainder of a given strain's genetic background. There is marked antigen-specific polymorphism between strains of different H-2 types with respect to their patterns of response.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D005796:Genes; D005838:Genotype; D006648:Histocompatibility; D007114:Immunization; D007178:Inbreeding; D051379:Mice; D010455:Peptides; D010641:Phenotype; D011110:Polymorphism, Genetic
D000941:Antigens; D010455:Peptides