Pituitary polypeptide with hypoglycaemic action in diabetes mellitus.
A polypeptide isolated by the hydrolysis of growth hormone, studied in five patients with diabetes mellitus, has been shown able to produce hypoglycaemia, presumably by modifying the anti-insulin action of pituitary growth hormone. Possibly this substance may be suitable for treating cases of insulin resistance or when a circulating inhibitor of glucose uptake is present.
D000328:Adult; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005947:Glucose / Q000378:metabolism; D013006:Growth Hormone / Q000032:analysis*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
D001786:Blood Glucose; D007328:Insulin; D010455:Peptides; D013006:Growth Hormone; D005947:Glucose