Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia.
Erythropoiesis in normal man was studied during periods of phlebotomy-induced anemia of varying severity. This study permitted a comparison of marrow production measurements over a wide range of marrow production levels. As long as the serum iron remained above 50 mug/100 ml, measurements of plasma iron turnover provided an excellent index of marrow production at all levels of red cell production. In contrast, the absolute reticulocyte count demonstrated a poor correlation with the other measurements. This was shown to be the result of a prolongation of the time required for circulating reticulocytes to lose their reticulum, which correlated with the severity of the anemia. For the clinical application of the reticulocyte count as a measurement of marrow production, an adjustment must be made for this alteration in the circulating reticulocyte maturation time.
D000328:Adult; D000740:Anemia / Q000503:physiopathology*; D001815:Bloodletting; D001853:Bone Marrow / Q000502:physiology*; D001854:Bone Marrow Cells; D002859:Chromium Isotopes; D004905:Erythrocyte Aging; D004906:Erythrocyte Count; D004920:Erythropoiesis; D006400:Hematocrit; D006432:Hemochromatosis; D006801:Humans; D007501:Iron / Q000097:blood; D007503:Iron Isotopes; D008297:Male; D008875:Middle Aged; D012156:Reticulocytes / Q000502:physiology*; D014680:Veins / Q000601:surgery
D002859:Chromium Isotopes; D007503:Iron Isotopes; D007501:Iron