Deoxycytidine and radiation response: exceedingly high deoxycytidine aminohydrolase activity in human liver.
The activity of deoxycytidine aminohydrolase in the liver of various species including man was investigated. An enormously high activity was found in human liver. This fact explains the extraordinarily low level of deoxycytidine in human urine in comparison with that of other tested species. The suitability of deoxycitidinuria as a biochemical indicator of postirradiation damage in man remains, therefore, an open question.
D000328:Adult; D000619:Aminohydrolases / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D002247:Carbon Isotopes; D002417:Cattle; D003857:Deoxyuridine / Q000378:metabolism; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009705:Nucleosides / Q000378:metabolism* / Q000652:urine; D011817:Rabbits; D011832:Radiation Injuries / Q000652:urine*; D051381:Rats; D013552:Swine
D002247:Carbon Isotopes; D009705:Nucleosides; D000619:Aminohydrolases; D003857:Deoxyuridine