Accumulation of 14C-streptomycin by streptomycin-sensitive and streptomycin-resistant group H streptococci.
Three streptomycin-resistant mutants of group H streptococcus, strain Challis, were examined for ability to accumulate (14)C-streptomycin. Although the mutants exhibited different levels of transformation, only the streptomycin-sensitive parent Challis strain accumulated significant amounts of (14)C-streptomycin. It appears that impermeability to streptomycin does not necessarily result in reduction or loss of transformability. The amount of label accumulated by strain Challis was correlated with a loss of viability. In addition, accumulation of label was influenced by the concentration of (14)C-streptomycin, the time of exposure, and the type of medium employed.
D002247:Carbon Isotopes; D003470:Culture Media; D004352:Drug Resistance, Microbial; D010539:Permeability; D013291:Streptococcus / Q000187:drug effects / Q000378:metabolism*; D013307:Streptomycin / Q000378:metabolism* / Q000494:pharmacology; D014170:Transformation, Genetic
D002247:Carbon Isotopes; D003470:Culture Media; D013307:Streptomycin