Genetic determinants of circadian rhythmicity in Neurospora.
Timex, a strain of Neurospora crassa which exhibits a circadian rhythm of conidia formation in growth-tube cultures, has been found to differ from wild-type strains by two genes. One gene, inv, is responsible for an invertase deficiency, whereas the second gene, bd, is of unknown function. Both genes map independently from other genes known to induce Neurospora rhythmicity. The inv gene is not essential for the timex phenotype because bd strains express that phenotype on certain media. Although inv strains do exhibit some rhythmicity of their own, the rhythmicity apparently is not a direct result of the invertase deficiency, since there is no correlation between invertase level and rhymicity in 29 strains tested. Of the 29 strains tested, 20 exhibited some rhythmicity in growth-tube cultures, suggesting that morphological manifestations of rhythmicity in Neurospora may result from the function or the loss of function of numerous genes, or both. There was no correlation in these strains between rhythmicity and (i) genetic background; (ii) geographical origin; or (iii) nutritional requirements.
D002940:Circadian Rhythm; D003433:Crosses, Genetic; D003470:Culture Media; D005796:Genes; D005827:Genetics, Microbial; D006026:Glycoside Hydrolases / Q000378:metabolism; D009491:Neurospora / Q000201:enzymology / Q000254:growth & development; D011995:Recombination, Genetic
D003470:Culture Media; D006026:Glycoside Hydrolases