Ocular lesions induced by the trachoma agent in rabbits.
Injection of the T'ang strain of trachoma agent into the anterior chamber of the rabbit eye caused corneal opacity, characteristic microscopic lesions of the corneal endothelium, varying degrees of neovascularization of the cornea, and uveitis. These ocular changes were agent-specific. The experimental data showed that the microorganism developed in the ocular tissues. The results of this study suggest the possibility of using the rabbit eye as an experimental model for the study of trachoma.
D000818:Animals; D000867:Anterior Chamber / Q000382:microbiology; D002689:Chlamydia / Q000302:isolation & purification; D003315:Cornea / Q000473:pathology; D003318:Corneal Opacity / Q000209:etiology; D004848:Epithelium; D008297:Male; D011817:Rabbits; D014141:Trachoma; D014605:Uveitis / Q000209:etiology