Interaction between analogue resistance and amino acid auxotrophy in Neurospora.
A new p-fluorophenylalanine resistant mutant of Neurospora (fpr-1) was isolated. It is unaffected by the suppressor of a previously described resistance mutant, mtr. The fpr-1 locus is on linkage group V, tightly linked to act-2. The expression of resistance to p-fluorophenylalanine by fpr-1 can be suppressed by genes controlling a requirement for lysine or arginine. The suppression seems to involve an increased sensitivity of the lysine and arginine auxotrophs to p-fluorophenylalanine.
D000596:Amino Acids / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005827:Genetics, Microbial; D008967:Molecular Biology; D009154:Mutation; D009491:Neurospora / Q000187:drug effects / Q000378:metabolism; D010649:Phenylalanine / Q000494:pharmacology
D000596:Amino Acids; D010649:Phenylalanine