Effect of intra-amniotic oestriol sulphate on uterine contractions.
The effects of oestriol sulphate on myometrial activity in a group of young primigravidae, who were at 41 or more weeks' gestation, are compared with those of a placebo in a double-blind trial. Both compounds were administered over a period of six hours directly into the uterine cavity following artificial rupture of membranes. Intra-amniotic pressure recordings demonstrated a peak in the mean intensity in uterine contractions in the oestriol-treated and placebo-treated groups at six and four hours, respectively. The length of labour tended to be shorter in those patients having greater uterine activity.
D000293:Adolescent; D000328:Adult; D000653:Amniotic Fluid; D004964:Estriol / Q000008:administration & dosage / Q000494:pharmacology*; D005321:Extraembryonic Membranes; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D010919:Placebos; D011247:Pregnancy; D011312:Pressure; D014599:Uterus / Q000187:drug effects*
D010919:Placebos; D004964:Estriol