Acetylcholine receptor: covalent attachment of depolarizing groups at the active site.
Following reduction of the acetylcholine receptor in the electroplax with dithiothreitol, the quaternary ammonium compounds bromoacetylcholine bromide and the p-nitrophenyl ester of (p-carboxyphenyl) trimethylammonium iodide react near the active site probably with a sulfhydryl group. The covalently attached quaternary ammonium moieties additionally interact with the active site noncovalently to activate the receptor and cause depolarization of the cell.
D000109:Acetylcholine; D000818:Animals; D001665:Binding Sites; D001965:Bromides / Q000494:pharmacology; D004524:Eels; D007454:Iodides / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011955:Receptors, Drug; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D001965:Bromides; D007454:Iodides; D000644:Quaternary Ammonium Compounds; D011955:Receptors, Drug; D013438:Sulfhydryl Compounds; D000109:Acetylcholine