Encephalitogenic protein: structure.
Amino acid sequences of encephalitogenic proteins from bovine cord and rabbit brain are reported. The bovine protein contains 45 residues. The rabbit protein is identical except for two isopolar substitutions, a dipeptide and amino acid deletion. Analysis of this protein and a 140-residue myelin basic protein indicates that the smaller protein is a portion of the larger encephalitogen. The larger myelin protein contains at least two encephalitogenic sites.
D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D002850:Chromatography, Gel; D002918:Chymotrypsin; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology*; D009186:Myelin Sheath / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009578:Nitrobenzenes; D010455:Peptides / Q000032:analysis*; D011817:Rabbits; D013116:Spinal Cord / Q000032:analysis*; D014357:Trypsin
D009419:Nerve Tissue Proteins; D009578:Nitrobenzenes; D010455:Peptides; D002918:Chymotrypsin; D014357:Trypsin