Abnormalities of the electrocardiogram in female carriers of Duchenne muscular dystrophy.
The algebraic sum of the R and S waves (R-S) in the V(1) lead of the electrocardiogram has been found to be significantly greater in female carriers of X-linked Duchenne muscular dystrophy (but not in women with limb-girdle muscular dystrophy) compared with normal women of comparable age. A similar E.C.G. abnormality is found in affected boys, and possibly certain carriers have a latent cardiomyopathy and may even be predisposed to cardiac failure.
D000328:Adult; D002353:Carrier State; D004562:Electrocardiography; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009136:Muscular Dystrophies / Q000235:genetics* / Q000503:physiopathology*