Amino acid incorporation into rat brain proteins during spreading cortical depression.
Unilateral spreading cortical depression was elicited by applying potassium chloride solutions to the dura of conscious, freely moving rats. Incorporation of (3)H-leucine into soluble cortical proteins was decreased in the depressed hemisphere relative to the control side, while soluble brainstem proteins from both sides had the same specific activity. Various subfractions of soluble cortical proteins were affected to equal degrees.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D001933:Brain Stem / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D013181:Cortical Spreading Depression; D004388:Dura Mater / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011188:Potassium / Q000378:metabolism; D011189:Potassium Chloride; D051381:Rats; D012964:Sodium / Q000378:metabolism; D012995:Solubility; D014020:Tissue Extracts; D014238:Trichloroacetic Acid; D014316:Tritium
D000596:Amino Acids; D009419:Nerve Tissue Proteins; D014020:Tissue Extracts; D014316:Tritium; D014238:Trichloroacetic Acid; D011189:Potassium Chloride; D012964:Sodium; D007930:Leucine; D011188:Potassium