Collagen has a discrete family of reactive hydroxylysyl and lysyl side-chain amino groups.
Several cross-linking substances which derive from lysine have been isolated from hydrolyzates of collagen and elastin. This observation suggests that certain lysyl side chains exhibiting enhanced reactivity and unique configuration may participate in cross-linking. In native collagen there is a small family of lysyl and hydroxylysyl side chains which exhibit a high propensity of Schiff base formation.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D003094:Collagen / Q000032:analysis*; D004549:Elastin / Q000032:analysis*; D006358:Hot Temperature; D008239:Lysine / Q000032:analysis*; D011489:Protein Denaturation; D011732:Pyridoxal Phosphate; D051381:Rats; D012867:Skin / Q000032:analysis; D013053:Spectrophotometry
D011732:Pyridoxal Phosphate; D003094:Collagen; D004549:Elastin; D008239:Lysine