Irreversible enzyme inhibitors. CXXXIX. p-(4,6-Diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. VI. Further studies on effects of substitution on the propionamide bridge on isozyme specificity.
D000577:Amides; D000818:Animals; D001555:Benzene Derivatives; D001665:Binding Sites; D002279:Carcinoma 256, Walker / Q000201:enzymology*; D055598:Chemical Phenomena; D002621:Chemistry; D005459:Fluorides; D005493:Folic Acid Antagonists; D007527:Isoenzymes; D007939:Leukemia L1210 / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D009281:Naphthalenes; D011422:Propionates; D051381:Rats; D013154:Spleen / Q000201:enzymology; D013451:Sulfonic Acids / Q000138:chemical synthesis*; D014050:Toluene; D014227:Triazines / Q000138:chemical synthesis
D000577:Amides; D001555:Benzene Derivatives; D005493:Folic Acid Antagonists; D007527:Isoenzymes; D009281:Naphthalenes; D011422:Propionates; D013451:Sulfonic Acids; D014227:Triazines; D014050:Toluene; D005459:Fluorides