Cyclophosphamide: effect on experimental allergic encephalomyelitis in Lewis rats.
Lewis rats sensitized to spinal cord in adjuvant and exhibiting advanced clinical paralytic signs of experimental allergic encephalomyelitis were treated with cyclophosphamide (5 milligrams per kilogram) daily. Of 30 treated animals, 21 recovered rapidly and appeared clinically well within 7 to 12 days. This immunosuppressive agent may prove therapeutically useful in the treatment of autoimmune diseases.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D051381:Rats; D013116:Spinal Cord / Q000276:immunology; D014020:Tissue Extracts
D007166:Immunosuppressive Agents; D014020:Tissue Extracts; D003520:Cyclophosphamide