Oxoenoic acids as metabolites in the bacterial degradation of catechols.
1. Partially purified extracts of a Pseudomonas converted the meta ring-fission product of 4-methylcatechol into a compound having spectroscopic and chemical properties consistent with its being 2-oxohex-4-enoic acid. 2. Catechol and 3-methylcatechol were both metabolized to a compound that appeared to be 2-oxopent-4-enoic acid. 3. Solutions of norvaline and norleucine were prepared from these metabolites. 4. A reaction scheme is presented for the conversion of catechols into hydroxyoxo acids after meta ring-fission.
D002208:Caproates / Q000096:biosynthesis* / Q000138:chemical synthesis; D002396:Catechols / Q000378:metabolism*; D002474:Cell-Free System; D002855:Chromatography, Thin Layer; D007651:Keto Acids / Q000096:biosynthesis*; D011549:Pseudomonas / Q000201:enzymology*; D013057:Spectrum Analysis; D014631:Valerates / Q000096:biosynthesis* / Q000138:chemical synthesis
D002208:Caproates; D002396:Catechols; D007651:Keto Acids; D014631:Valerates