Secretory activity and oncogenicity of a cell line (MDCK) derived from canine kidney.
A cell line (MDCK) of dog kidney origin grows on a glass surface as a mosaic of epithelium with many multicellular hemispherical vesicles. The cells lining the blisters actively secrete into the cyst cavities. Suspensions of these cells injected intravenously in the chick embryo produce brain metastases resembling adenocarcinoma.
D000230:Adenocarcinoma / Q000209:etiology; D000818:Animals; D001932:Brain Neoplasms / Q000209:etiology; D002471:Cell Transformation, Neoplastic; D002642:Chick Embryo; D046508:Culture Techniques; D004285:Dogs; D007668:Kidney / Q000166:cytology; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000209:etiology*