Purines: active transport by isolated choroid plexus.
Purines are actively accumulated by the isolated rabbit choroid plexus by a specific saturable transport mechanism. In vivo this system probably serves to excrete the purine catabolities of brain from cerebrospinal fluid into blood.
D000225:Adenine / Q000494:pharmacology; D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active; D001812:Blood-Brain Barrier; D002831:Choroid Plexus / Q000378:metabolism*; D005260:Female; D006147:Guanine / Q000494:pharmacology; D007042:Hypoxanthines / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D011687:Purines / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D011817:Rabbits; D014498:Uracil / Q000494:pharmacology; D014527:Uric Acid / Q000494:pharmacology; D014970:Xanthines / Q000378:metabolism*
D007042:Hypoxanthines; D011687:Purines; D014970:Xanthines; D014527:Uric Acid; D014498:Uracil; D006147:Guanine; D000493:Allopurinol; D000225:Adenine