Chemotherapeutic activity of 5-fluorocytosine against a lethal Candida albicans infection in mice.
Numerous strains of Candida were inhibited by low concentrations of 5-fluorocytosine in vitro. Marked increase in life span occurred in C. albicans-infected mice treated with 5-fluorocytosine.
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy*; D003596:Cytosine / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice
D000935:Antifungal Agents; D000666:Amphotericin B; D003596:Cytosine