Leukotactic factor produced by sensitized lymphocytes.
Lymph node lymphocytes obtained from guinea pigs exhibiting delayed hypersensitivity are stimulated in vitro by specific antigen to produce a soluble factor that is chemotactic in vitro for mononuclear macrophages. The material is nondialyzable, relatively heat stable, and elutes from Sephadex G-100 in the fraction containing molecules smaller than immunoglobulins.
D000818:Animals; D000941:Antigens; D003585:Cell Biology; D002633:Chemotaxis; D002850:Chromatography, Gel; D003956:Dialysis; D006168:Guinea Pigs; D006358:Hot Temperature; D006968:Hypersensitivity, Delayed; D007962:Leukocytes; D008214:Lymphocytes; D011817:Rabbits
D000941:Antigens