Irreversible enzyme inhibitors. CXXXVII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-(p-aminomethylphenoxymethyl)-2,4-diamino-5-(3,4-dichlorophenyl)pyrimidine bearing a terminal sulfonyl fluoride.
D000818:Animals; D001555:Benzene Derivatives; D001665:Binding Sites; D002219:Carbamates; D055598:Chemical Phenomena; D002621:Chemistry; D002713:Chlorine; D005459:Fluorides; D005493:Folic Acid Antagonists; D007527:Isoenzymes; D007939:Leukemia L1210 / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis; D013451:Sulfonic Acids / Q000138:chemical synthesis
D001555:Benzene Derivatives; D002219:Carbamates; D005493:Folic Acid Antagonists; D007527:Isoenzymes; D011743:Pyrimidines; D013451:Sulfonic Acids; D002713:Chlorine; D005459:Fluorides