Macroglobulin structure: homology of mu and gamma heavy chains of human immunoglobulins.
The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human gammaM-globulin is homologous to the NH(2)-terminal sequences of the gamma-chain of human and rabbit gammaG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D001965:Bromides; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D002918:Chymotrypsin; D003486:Cyanides; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D008259:Macroglobulins / Q000032:analysis; D008967:Molecular Biology; D010455:Peptides / Q000032:analysis*; D011817:Rabbits; D014357:Trypsin
D001965:Bromides; D003486:Cyanides; D007075:Immunoglobulin M; D008259:Macroglobulins; D010455:Peptides; D002918:Chymotrypsin; D014357:Trypsin