Esterification of injected epicoprostanol in a human subject.
That a necessary requirement for in vivo esterification of 3-hydroxy sterols is the equatorial conformation of the hydroxyl group has been substantiated by the administration of epicoprostanol-3-(3)H (3-OH equatorial) to a man with a complete biliary fistula. Radioactive epicoprostanol was identified in both free and esterified sterols of plasma. The specific activity of biliary sterols was much higher than that of plasma sterols; this indicated a preferential removal of epicoprostanol from circulating sterols. The appearance of tritium in body water demonstrated that a portion of the labeled epicoprostanol underwent oxidation at C-3.
D000368:Aged; D001646:Bile / Q000378:metabolism; D001658:Biliary Fistula / Q000378:metabolism; D002776:Cholestanes / Q000378:metabolism*; D004952:Esters / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005706:Gallbladder Neoplasms / Q000378:metabolism; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D013261:Sterols / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013274:Stomach Neoplasms / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D002776:Cholestanes; D004952:Esters; D013261:Sterols; D014316:Tritium