Ribonucleic acid biosynthesis in adult and infant rat brain in vitro.
The rate of biosynthesis of ribonucleic acid (as judged by the rate of incorporation of uridine into ribonucleic acid) in infant and adullt rat brain cortex slices, incubated (aerobically in tile presenice of various substrates, is directly proportionial to the adenosine triphosphate concentration. This suggests that the adenosine triphosphate concentration is one of the factors involved in the control of ribonucleic acid biosynthesis in infant and adult rat brain. Acetoacetate or beta-hydroxybutyrate is about 70 percent as effective as glucose, with both infant and adult brain, for the promotion of ribonucleic acid biosynthesis. but they are considerably mnore effective than succinate in infant brain than in adult brain.
D000090:Acetoacetates / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry; D002247:Carbon Isotopes; D002540:Cerebral Cortex / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006885:Hydroxybutyrates / Q000378:metabolism; D066298:In Vitro Techniques; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013386:Succinates / Q000378:metabolism; D014500:Uracil Nucleotides / Q000032:analysis; D014529:Uridine / Q000378:metabolism
D000090:Acetoacetates; D002247:Carbon Isotopes; D006885:Hydroxybutyrates; D013386:Succinates; D014500:Uracil Nucleotides; D012313:RNA; D000255:Adenosine Triphosphate; D005947:Glucose; D014529:Uridine