Chloramphenicol: effects on mouse myeloma cells in tissue culture.
Within 36 hours of being administered, chloramphenicol (50 micrograms per milliliter) inhibits by 50 percent the rate of protein synthesis in mouse myeloma cells grown in suspension culture. Although there is a decrease in the amount of globulin synthesized, the rate of synthesis per cell is unchanged; the observed decrease is traced to the inhibition of cell proliferation caused by chloramphenicol.
D000818:Animals; D002247:Carbon Isotopes; D002455:Cell Division / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology*; D046508:Culture Techniques; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D051379:Mice; D009101:Multiple Myeloma / Q000188:drug therapy*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D002247:Carbon Isotopes; D009363:Neoplasm Proteins; D002701:Chloramphenicol; D007930:Leucine