Lysergic acid diethylamide: effects on the developing mouse lens.
High doses (5 x 10-(6) gram) of LSD-25 given to Swiss-Webster females on gestation days 6, 7, 8, or 9 caused a high incidence of anterior subcapsular lens abnormalities. Accompanying this, the lens epithelium was often hyperplastic, and the lens bow was widened posteriorly in a fashion similar to cataracts induced by x-radiation. Confirmation of this effect of LSD-25 was obtained by a (duplicate) experiment 1 year after the observations reported.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D004848:Epithelium / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D006965:Hyperplasia; D007908:Lens, Crystalline / Q000002:abnormalities / Q000187:drug effects*; D008238:Lysergic Acid Diethylamide / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal
D008238:Lysergic Acid Diethylamide