Some active derivatives of penicillin.
The antibacterial activities of a number of amide derivatives of penicillin against both penicillin-sensitive and penicillin-resistant cultures were determined. Several of them were found to possess significant inhibitory activity against certain gram-positive bacteria. The amides, although resistant to the destructive action of beta-lactamase, did not protect G in competitive experiments. One derivative, the O-benzylhydroxamide of penicillin G, was active against six or eight penicillin-resistant strains of Staphylococcus aureus (minimal inhibitory concentration, 0.2 mug/ml or less), but was found to have only a minimal in vivo activity against mouse Streptococcus infections.
D000577:Amides / Q000494:pharmacology; D000667:Ampicillin / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D003023:Cloxacillin / Q000627:therapeutic use; D051379:Mice; D010068:Oxacillin / Q000494:pharmacology; D010400:Penicillin G / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D010403:Penicillin Resistance; D010405:Penicillinase; D010406:Penicillins / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy
D000577:Amides; D010406:Penicillins; D000667:Ampicillin; D010405:Penicillinase; D003023:Cloxacillin; D010400:Penicillin G; D010068:Oxacillin