Stress effect of antilymphocyte serum.
Antilymphocyte serum prepared in the rabbit against guinea-pig lymph node cells produces a sustained weight loss when injected into normal guinea-pigs over 14 days, compared with a very transient loss produced by normal rabbit serum. Antilymphocyte serum also produces a much greater increase in plasma cortisol level than normal rabbit serum. Part of this effect may be due to adrenal stimulation, and further studies of its activity in adrenalectomized animals are suggested.
D000315:Adrenalectomy; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects*; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000097:blood*; D007106:Immune Sera / Q000008:administration & dosage / Q000494:pharmacology*; D008214:Lymphocytes; D009132:Muscles / Q000473:pathology; D011817:Rabbits
D000961:Antilymphocyte Serum; D007106:Immune Sera; D006854:Hydrocortisone