Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity.
D000818:Animals; D001555:Benzene Derivatives; D001665:Binding Sites; D002219:Carbamates; D002713:Chlorine; D005459:Fluorides; D005493:Folic Acid Antagonists; D007422:Intestines / Q000201:enzymology; D007527:Isoenzymes; D007939:Leukemia L1210 / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis; D013154:Spleen / Q000201:enzymology; D013451:Sulfonic Acids / Q000138:chemical synthesis
D001555:Benzene Derivatives; D002219:Carbamates; D005493:Folic Acid Antagonists; D007527:Isoenzymes; D011743:Pyrimidines; D013451:Sulfonic Acids; D002713:Chlorine; D005459:Fluorides