The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum.
Expression of the rate of inactivation of isonicotinoyl hydrazide (INH) as a first-order constant gave better discrimination of slow and rapid inactivators than did the level of INH at the end of 6 hr. The most probable division point between the two classes was at k = 0.130. Rate of inactivation by obligatory heterozygotes was determined. Such heterozygotes could not be adequately differentiated from homozygous rapid inactivators. The gene frequency for slow inactivation was 0.46 +/-0.04 in Alaskan Eskimos and 0.62+/-0.06 in Athabaskan Indians.
D000413:Alaska; D005470:Fluorometry; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007198:Indians, North American; D004930:Inuit; D007538:Isoniazid / Q000097:blood*; D008657:Metabolic Clearance Rate; D008722:Methods; D010641:Phenotype
D007538:Isoniazid