Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate.
Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations / Q000187:drug effects*; D003510:Cyclohexanes / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D013094:Spermatozoa / Q000187:drug effects; D013549:Sweetening Agents / Q000378:metabolism*
D000588:Amines; D003510:Cyclohexanes; D013549:Sweetening Agents