Obstructive lung disease and alpha-1-antitrypsin deficiency gene heterozygosity.
The phenotypes of serum alpha(1)-antitrypsin were determined by antigenantibody crossed electrophoresis. There were five homozygotes and 25 heterozygotes for the deficiency gene found in a group of 103 patients with obstructive lung disease. The frequency of heterozygotes was 14 and 9 percent in two control groups with different mean ages of 36 and 80. There was only one heterozygote among 39 healthy males over 70 years of age. Heterozygosity may be a predisposing factor in chronic obstructive lung disease, especially in the male population.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000937:Antigen-Antibody Reactions; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D007122:Immunoelectrophoresis; D008171:Lung Diseases / Q000097:blood / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000097:blood*; D008875:Middle Aged; D010641:Phenotype; D012737:Sex Factors; D012907:Smoking; D014361:Trypsin Inhibitors
D014361:Trypsin Inhibitors