Epinephrine metabolism in mammalian brain after intravenous and intraventricular administration.
Epinephrine given intravenously or intraventricularly has a half-life in the brain of the rat of 2 to 2.5 hours. After intravenous administration of the drug the principal route of metabolism is O-methylation, whereas after intraventricular administration the principal route is conjugation.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002852:Chromatography, Ion Exchange; D004837:Epinephrine / Q000008:administration & dosage / Q000378:metabolism; D007275:Injections, Intravenous; D008297:Male; D008745:Methylation; D051381:Rats; D014316:Tritium
D014316:Tritium; D004837:Epinephrine