Comparison of the effects of food and carbachol on the absorption of vitamin B 12 after partial gastrectomy.
Absorption of radioactive vitamin B(12) was measured by the Schilling procedure in 14 patients who had had a partial gastrectomy. Injection of carbachol (250 mug) before the administration of the test dose increased absorption to a much smaller degree than the ingestion of a light meal containing a minimal quantity of the natural vitamin. The results support the belief that food may improve absorption of vitamin B(12) after partial gastrectomy by stimulating the secretion of a small residual amount of intrinsic factor.
D002217:Carbachol / Q000494:pharmacology*; D003036:Cobalt Isotopes; D005502:Food; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007437:Intrinsic Factor / Q000378:metabolism; D012546:Schilling Test; D013268:Stimulation, Chemical; D014805:Vitamin B 12 / Q000378:metabolism*
D003036:Cobalt Isotopes; D002217:Carbachol; D007437:Intrinsic Factor; D014805:Vitamin B 12