Effects of beta-adrenergic receptor blockade on airway conductance and lung volume in normal and asthmatic subjects.
Ten normal and five asthmatic subjects were given intravenous injections of 10 ml. of 0.9% saline with and without 10 mg. of propranolol, and specific airway conductance was followed in a whole-body plethysmograph. Saline alone had no significant effect on conducatance in either group of subjects. Propranolol had no significant effect on conductance in normal subjects, but caused a mean fall of 34.9% in the asthmatics.
D001249:Asthma / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000187:drug effects; D010991:Plethysmography; D011433:Propranolol / Q000494:pharmacology*; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D011433:Propranolol