Induction in vitro of microtubular crystals by vinca alkaloids.
The addition of vinblastine or vincristine to solutions of pure microtubule protein or to supernatants from high-speed centrifugation of rabbit-brain homogenates results in the formation of a fine precipitate. Examination of this precipitate by electron microscopy reveals ordered structures with areas of ladder-like configuration.
D000818:Animals; D001923:Brain Chemistry; D011232:Chemical Precipitation; D003460:Crystallization; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D011506:Proteins; D011817:Rabbits; D013552:Swine; D014747:Vinblastine; D014750:Vincristine
D011506:Proteins; D014750:Vincristine; D014747:Vinblastine