Tumor induction in developing frog kidneys by a zonal centrifuge purified fraction of the frog herpes-type virus.
Injection of frog embryos (Rana pipiens) with a zonal centrifuge purified fraction of herpes-type virus (prepared from virus-containing Lucké tumors) resulted in a high incidence of kidney tumors. This partially purified oncogenic fraction contained a high concentration of an enveloped form of the frog herpes-type virus (adjacent fractions lacked this particle and were not oncogenic), which suggests that this form of the virus plays a role in the genesis of the Lucké tumor.
D000818:Animals; D001001:Anura; D002501:Centrifugation, Zonal; D004625:Embryo, Nonmammalian; D006564:Herpesviridae / Q000472:pathogenicity*; D007267:Injections; D007680:Kidney Neoplasms / Q000382:microbiology*; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental / Q000382:microbiology*