Enzymatic phosphorylation of streptomycin by extracts of streptomycin-producing strains of Streptomyces.
Extracts of post-exponential phase mycelia of Streptomyces bikiniensis ATCC 11062, and other streptomycin-producers, catalyze phosphorylation of streptomycin and dihydrostreptomycin with adenosine-5'-triphosphate. The phosphate is esterified with an -OH group of the streptidine moiety. It is suggested that O-phosphoryl-streptomycin might serve as an intracellular precursor of extracellular streptomycin or as a detoxification product of streptomycin or that it might serve an unknown physiological function in the producing organism.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D010759:Phosphorus Isotopes; D010770:Phosphotransferases / Q000378:metabolism*; D013302:Streptomyces / Q000201:enzymology / Q000378:metabolism*; D013307:Streptomycin / Q000378:metabolism*
D002247:Carbon Isotopes; D010759:Phosphorus Isotopes; D000255:Adenosine Triphosphate; D010770:Phosphotransferases; D000469:Alkaline Phosphatase; D013307:Streptomycin