Irreversible enzyme inhibitors. CLV. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[4-(omega-aminoalkoxy)-3-chlorophenyl]-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazines bearing a terminal sulfonyl fluoride.
D000818:Animals; D046508:Culture Techniques; D005493:Folic Acid Antagonists; D007939:Leukemia L1210 / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D051379:Mice; D013997:Time Factors; D014227:Triazines / Q000138:chemical synthesis / Q000494:pharmacology*
D005493:Folic Acid Antagonists; D014227:Triazines