Effect of gaboon viper (Bitis gabonica) venom on blood coagulation, platelets, and the fibrinolytic enzyme system.
The action of the venom of the gaboon viper (Bitis gabonica) on blood coagulation, platelets, and the fibrinolytic enzyme system was studied. The results confirm that the venom of Bitis gabonica has a marked anticoagulant action in vitro. The venom appears to impair clot formation by a direct proteolytic action on fibrinogen, releasing soluble breakdown products.
D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects*; D002364:Caseins; D005340:Fibrinogen; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D012911:Snakes; D013917:Thrombin; D013925:Thromboplastin; D014688:Venoms / Q000494:pharmacology*
D000227:Adenine Nucleotides; D000925:Anticoagulants; D002364:Caseins; D014688:Venoms; D005340:Fibrinogen; D013925:Thromboplastin; D013917:Thrombin