Oxygen-hemoglobulin dissociation curves: effect of inherited enzyme defects of the red cell.
The blood of a patient with a deficiency of hexokinase in the red cells and a decreased concentration of 2, 3-diphosphoglycerate in the red cells showed an increased affinity for oxygen, whereas a patient with a deficiency of pyruvate kinase and an elevated concentration of 2, 3-diphosphoglycerate in the red cells had blood with a decreased affinity for oxygen. Defects in red cell glycolysis may alter the oxygen affinity of blood by virtue of their effect on 2, 3-diphosphoglycerate concentrations in red cells.
D004912:Erythrocytes / Q000201:enzymology*; D005994:Glycerophosphates / Q000097:blood; D006454:Hemoglobins; D006593:Hexokinase / Q000097:blood*; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000097:blood*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D011770:Pyruvate Kinase / Q000097:blood*
D005994:Glycerophosphates; D006454:Hemoglobins; D006593:Hexokinase; D011770:Pyruvate Kinase; D010100:Oxygen