Meabolites of octoclothepin eliminated in human and ratuine.
1. Four metabolites and unchanged octoclothepin were extracted with dichloroethane from the urine of humans given octoclothepin. These substances were isolated and purified by column and thin-layer chromatography. 2. By chromatographic, spectrophotometric and polarographic analysis, unchanged octoclothepin and three of the metabolites were identified (noroctoclothepin, noroctoclothepin S-oxide and octoclothepin S-oxide). 3. The presence of glucuronides in human urine was proved. 4. The same metabolites and unchanged octoclothepin were also found in rat urine by chromatography.
D000818:Animals; D002845:Chromatography; D002855:Chromatography, Thin Layer; D003988:Dibenzothiepins / Q000378:metabolism*; D005260:Female; D005965:Glucuronates / Q000378:metabolism / Q000652:urine*; D006801:Humans; D008297:Male; D011048:Polarography; D051381:Rats; D013053:Spectrophotometry
D003988:Dibenzothiepins; D005965:Glucuronates