Severe depressive mood changes following slow-release intramuscular fluphenazine injection.
Sixteen patients in whom schizophrenia was initially diagnosed and who were treated with fluphenazine enanthate or decanoate developed severe depression for a short period after the injection. In five cases this depression is thought to have been responsible for suicide. In 8 out of 10 cases the depression responded to electroplexy (E.C.T.). It is recommended that patients who are treated with fluphenazine should be carefully supervised.
D000328:Adult; D003692:Delayed-Action Preparations; D003863:Depression / Q000139:chemically induced*; D004565:Electroconvulsive Therapy; D005260:Female; D005476:Fluphenazine / Q000009:adverse effects*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy; D013405:Suicide
D003692:Delayed-Action Preparations; D005476:Fluphenazine