Lysergic acid diethylamide: role in conversion of plasma tryptophan to brain serotonin (5-hydroxytryptamine).
Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of (14)C-tryptophan into (14)C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of (14)C-tryptophan conversion into (14)C-5-hydroxytryptamine. The effect of D-lysergic acid diethylamide is discussed with regard to its action on brain serotonergic neurons and its psychotomimetic effects.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D001966:Bromine; D002247:Carbon Isotopes; D007275:Injections, Intravenous; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008956:Models, Chemical; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000097:blood / Q000378:metabolism*
D002247:Carbon Isotopes; D012701:Serotonin; D014364:Tryptophan; D008238:Lysergic Acid Diethylamide; D001966:Bromine