Microbiological metabolism of naphthyridines.
Penicillium adametzi and seven other species convert nalidixic acid, 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid, to 1,4-dihydro-1-ethyl-7-hydroxymethyl-4-oxo-1,8-naphthyridine-3-carboxylic acid. Forty-seven other species from six orders of fungi seem to achieve the same conversion as judged by chromatographic and spectral evidence. Under special conditions, P. adametzi also produces a second metabolite which was identified as the corresponding 7-carboxylic acid. The metabolic attack on the ring substituent is identical with the pathway previously established with humans. No evidence was obtained for metabolic attack on the naphthyridine nucleus itself.
D001203:Ascomycota / Q000378:metabolism; D001230:Aspergillus / Q000378:metabolism; D001711:Biotransformation; D002854:Chromatography, Paper; D005658:Fungi / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000378:metabolism; D009268:Nalidixic Acid / Q000378:metabolism*; D009287:Naphthyridines / Q000032:analysis / Q000378:metabolism*; D010407:Penicillium / Q000378:metabolism*; D013057:Spectrum Analysis
D009287:Naphthyridines; D009268:Nalidixic Acid