Chromosome abnormalities in patients treated with chlorpromazine, perphenazine, and lysergide.
In a chromosome study on leucocyte cultures made in 13 patients treated with chlorpromazine, 15 treated with perphenazine, and nine treated with lysergide, a significantly higher frequency of gaps, breaks, and hypodiploid cells in the patients treated with perphenazine and lysergide occurred compared with the 41 controls studied. It is concluded that if some drugs can induce major chromosome abnormalities, and less toxic alternatives are available, the latter should be used in preference.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002746:Chlorpromazine / Q000008:administration & dosage / Q000009:adverse effects*; D002869:Chromosome Aberrations; D046508:Culture Techniques; D004873:Ergolines / Q000008:administration & dosage; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D008238:Lysergic Acid Diethylamide / Q000009:adverse effects*; D008875:Middle Aged; D010546:Perphenazine / Q000008:administration & dosage / Q000009:adverse effects*; D013223:Statistics as Topic
D004873:Ergolines; D008238:Lysergic Acid Diethylamide; D010546:Perphenazine; D002746:Chlorpromazine