Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo.
Two diphosphonates containing the P-C-P bond, Cl(2)C(PO(3)HNa)(2), and H(2)C(PO(3)HNa)(2) retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.
D000818:Animals; D001665:Binding Sites; D001862:Bone Resorption / Q000187:drug effects*; D046508:Culture Techniques; D006882:Hydroxyapatites / Q000037:antagonists & inhibitors*; D051379:Mice; D063065:Organophosphonates / Q000494:pharmacology*; D010280:Parathyroid Glands / Q000601:surgery; D051381:Rats; D012996:Solutions / Q000037:antagonists & inhibitors*; D013965:Thyroidectomy; D014020:Tissue Extracts / Q000494:pharmacology
D006882:Hydroxyapatites; D063065:Organophosphonates; D012996:Solutions; D014020:Tissue Extracts