A diffusible factor which sustains contact inhibition of replication.
Confluent 3T3 cultures make and release into the medium a diffusible factor which sustains the state of contact inhibition of replication. Evidence is given that the factor is a specific and reversible inhibitor of the RNA synthesis which precedes cellular replication.
D000818:Animals; D000963:Antimetabolites / Q000032:analysis* / Q000494:pharmacology; D002247:Carbon Isotopes; D003585:Cell Biology; D002455:Cell Division / Q000187:drug effects*; D003260:Contact Inhibition; D003470:Culture Media / Q000494:pharmacology; D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis; D003956:Dialysis; D004058:Diffusion; D008722:Methods; D051379:Mice; D012313:RNA / Q000037:antagonists & inhibitors*; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D000963:Antimetabolites; D002247:Carbon Isotopes; D003470:Culture Media; D012313:RNA; D004247:DNA; D013936:Thymidine; D014529:Uridine