Correlation between growth inhibition and the binding of various penicillins and cephalosporins to Staphylococcus aureus.
The concentration of penicillin (or cephalosporin) required to achieve a given rate of binding to Staphylococcus aureus H correlates well with that required for inhibition of growth. This result suggests that the irreversible binding of penicillins and cephalosporins to cells is responsible for their biological activity.
D000667:Ampicillin / Q000494:pharmacology; D001665:Binding Sites; D002247:Carbon Isotopes; D002509:Cephaloridine / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology; D003023:Cloxacillin / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology; D010068:Oxacillin / Q000494:pharmacology; D010400:Penicillin G / Q000378:metabolism / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D002247:Carbon Isotopes; D002511:Cephalosporins; D010406:Penicillins; D000667:Ampicillin; D002509:Cephaloridine; D003023:Cloxacillin; D010400:Penicillin G; D008712:Methicillin; D002512:Cephalothin; D010068:Oxacillin