Serum elastase inhibitor deficiency and alpha 1-antitrypsin deficiency in patients with obstructive emphysema.
A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with alpha(1)-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.
D000328:Adult; D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000201:enzymology*; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000097:blood*; D011656:Pulmonary Emphysema / Q000201:enzymology* / Q000235:genetics; D014357:Trypsin / Q000097:blood*; D014361:Trypsin Inhibitors
D014361:Trypsin Inhibitors; D010196:Pancreatic Elastase; D014357:Trypsin