Intellectual deficit associated with transplacentally induced microcephaly in the rat.
Fischer rats injected with methylazoxymethanol late in pregnancy produce young with considerably reduced cerebral hemispheres. They appear normal otherwise. As adults these animals make many more errors in the Hebb-Williams maze than do control animals.
D000014:Abnormalities, Drug-Induced; D000438:Alcohols / Q000633:toxicity*; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D001921:Brain; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007859:Learning Disabilities / Q000150:complications; D008297:Male; D008431:Maternal-Fetal Exchange; D008831:Microcephaly / Q000139:chemically induced* / Q000150:complications; D009929:Organ Size; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats
D000438:Alcohols; D001391:Azo Compounds; D002273:Carcinogens