Antifungal steroid glycoside from sea cucumber.
An antifungal steroid glycoside, holotoxin, has been isolated from the sea cucumber Stichopus japonicus (Selenka). In vitro, it exhibits high activity against various fungi, including vegetable pathogens, but has scarcely any activity against Gram-positive and Gram-negative bacteria and mycobacteria in vitro.
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D003454:Cryptococcus / Q000187:drug effects; D003864:Depression, Chemical; D004447:Echinodermata; D005670:Fusarium / Q000187:drug effects; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000187:drug effects; D010407:Penicillium / Q000187:drug effects; D012440:Saccharomyces / Q000187:drug effects; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D006027:Glycosides; D013256:Steroids