Inhibition by aspirin of release of antiheparin activity from human platelets.
Both in vitro and in vivo, aspirin inhibited the adenosine diphosphate and collagen-induced release of platelet factor 4 (antiheparin factor). The release induced by adrenaline and thrombin was not affected. The in-vivo effect in normal persons lasted for at least three days. Platelet uptake of acetyl-(14)C-aspirin was significantly greater than that of carboxyl-(14)C-aspirin.
D000227:Adenine Nucleotides; D001241:Aspirin / Q000378:metabolism / Q000494:pharmacology*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium; D002247:Carbon Isotopes; D003094:Collagen; D004837:Epinephrine; D006801:Humans; D066298:In Vitro Techniques; D013917:Thrombin
D000227:Adenine Nucleotides; D001779:Blood Coagulation Factors; D002247:Carbon Isotopes; D003094:Collagen; D013917:Thrombin; D001241:Aspirin; D002118:Calcium; D004837:Epinephrine