Turnover of ribosomal RNA in rat liver.
After a single injection of radioactive orotic acid and a "chase" of nonradioactive precursor, the specific activity of ribosomal RNA in rat liver decreases logarithmically at a rate corresponding to a half-life of about S days. The possible significance of this result is discussed with regard to control of protein synthesis.
D000818:Animals; D002247:Carbon Isotopes; D008099:Liver / Q000166:cytology* / Q000378:metabolism*; D009963:Orotic Acid / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D011874:Radiometry; D051381:Rats
D002247:Carbon Isotopes; D009963:Orotic Acid; D012313:RNA