Aminoacid constitution of two gastrins isolated from Zollinger-Ellison tumour tissue.
Two peptides which are potent stimulants of gastric acid secretion are isolated from Zollinger-Ellison tumour tissue. They have aminoacid constitutions identical with those of human gastrin types I and II as isolated from human antral mucosa, and they are present in similar proportions. Their electrophoretic and chromatographic behaviour corresponds to that of human gastrins. Evidence is presented in respect of the one isolated in greater amount that its aminoacid sequence is probably identical with that of human gastrin type I.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D002415:Cats; D002855:Chromatography, Thin Layer; D004285:Dogs; D004586:Electrophoresis; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000032:analysis*; D006801:Humans; D009362:Neoplasm Metastasis; D010179:Pancreas / Q000032:analysis; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism*
D000596:Amino Acids; D005755:Gastrins; D010455:Peptides
Nature. 1965 Sep 25;207(5004):1356-9
5886035
Nature. 1966 Feb 5;209(5023):583
5921182
Lancet. 1967 Sep 9;2(7515):543-4
4166897
N Engl J Med. 1968 Jun 13;278(24):1308-13
5648596
Surgery. 1968 Jul;64(1):165-74
4173157
Nature. 1952 May 31;169(4309):922
14941086
J Physiol. 1958 Nov 10;144(1):123-37
13599113
Gastroenterology. 1961 May;40:644-8
13779447
Gut. 1964 Apr;5:103-14
14159395
Nature. 1964 Dec 5;204:931-3
14248711