Carcinogen-induced immune depression: absence in mice resistant to chemical oncogenesis.
Administration of 3-methylcholanthrene 6 days before antigenic challenge depressed the immune response to sheep red cells in young adult mice (C3Hf/Bi strain) sensitive to the oncogenic effect of the drug (100 percent local tumors 240 days after carcinogen). The drug was not immunodepressant in the I strain, which is relatively resistant to its carcinogenic effect (11 percent local tumors 240 days after carcinogen).
D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008748:Methylcholanthrene / Q000494:pharmacology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D012756:Sheep
D007166:Immunosuppressive Agents; D008748:Methylcholanthrene