Histamine synthesis and gastric secretion after portacaval shunt.
In man there is an increased incidence of peptic ulcer after portacaval shunt. In the rat, 2 months after portacaval anastomosis, there is a generalized increase in the histamine content of the soft tissues, and the increase is most marked in the acid-secreting portion of the stomach. This appears to be secondary to increased activity of the histamine-synthesizing enzyme, histidine decarboxylase. A histidine decarboxylase inhibitor can prevent such hypersecretion of acid in the stomach of these animals.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism; D005745:Gastric Acidity Determination; D005750:Gastric Juice; D006632:Histamine / Q000096:biosynthesis*; D066298:In Vitro Techniques; D011167:Portacaval Shunt, Surgical; D051381:Rats
D006632:Histamine; D002262:Carboxy-Lyases