Uptake as a determinant of methotrexate response in mouse leukemias.
Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r(2) = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.
D000818:Animals; D046508:Culture Techniques; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D008727:Methotrexate / Q000378:metabolism* / Q000627:therapeutic use*; D051379:Mice; D009026:Mortality
D008727:Methotrexate