Comparative studies of bile salts. 16-Deoxymyxinol, a second bile alcohol from hagfish.
1. Material containing the less polar sulphate previously noticed in hagfish bile salts gave, after dioxan-trichloroacetic acid cleavage, 16-deoxymyxinol [3beta,7alpha,-26(27)-trihydroxy-5alpha-cholestane]. 2. Anodic coupling of 3beta-hydroxy-5beta-cholanoic acid and the mixed half esters of dl-methylsuccinic acid, followed by lithium aluminium hydride reduction, yielded 3beta,26(27)-dihydroxy-5beta-cholestane. 3. 16-Deoxymyxinol, the third known bile alcohol having the 3beta-hydroxy-5alpha-hydrogen configuration, poses again the question of how the 3beta-hydroxyl group of cholesterol can be ;retained' in biosynthesis of primitive bile salts.
D000438:Alcohols; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D002776:Cholestanes / Q000138:chemical synthesis / Q000302:isolation & purification; D005399:Fishes; D007259:Infrared Rays; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D013057:Spectrum Analysis; D013261:Sterols / Q000138:chemical synthesis / Q000302:isolation & purification
D000438:Alcohols; D001647:Bile Acids and Salts; D002776:Cholestanes; D013261:Sterols
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