Creatinine clearance in renal disease. A reappraisal.
To determine the validity of endogenous creatinine clearance as a measure of glomerular filtration rate in patients with renal disease 308 simultaneous determinations of inulin clearance and endogenous creatinine clearance were reviewed and analysed. The ratio of creatinine clearance/inulin clearance increased progressively with the decline in inulin clearance, while the finding of a normal endogenous creatinine clearance masked a definite but mild decrease of glomerular filtration rate in 42% of the patients and a moderate decrease of glomerular filtration rate in 23%. This indicates that with declining glomerular filtration rates the endogenous creatinine clearance progressively overestimates actual glomerular filtration rates. Hence a single determination of creatinine clearance can be misleading as a screening measurement of glomerular filtration rate.
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007444:Inulin / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged
D007444:Inulin; D003404:Creatinine
Lancet. 1964 Oct 24;2(7365):874-6
14197181
J Clin Invest. 1938 Jan;17(1):31-40
16694545
J Clin Invest. 1941 Mar;20(2):169-76
16694822
Lancet. 1964 Dec 12;2(7372):1299
14219154
J Clin Invest. 1952 Mar;31(3):309-13
14917745
Australas Ann Med. 1959 Aug;8:218-24
13819423
Acta Med Scand. 1957 Feb 2;156(6):429-34
13402411
N Engl J Med. 1962 Feb 15;266:317-23
13921458
Am J Med. 1962 Jan;32:65-79
13887292
J Clin Invest. 1952 Oct;31(10):938-46
12990666
Can Med Assoc J. 1968 Jul 27;99(4):149-56
5673222
Klin Wochenschr. 1953 Jun 1;31(21-22):489-96
13085704