The effect of membrane polarization on the time course of the end-plate current in frog sartorius muscle.
1. Intracellular recordings of the end-plate current at different membrane potentials were made, using a voltage-clamp technique.2. When the membrane potential is varied between about +40 and -120 mV, the half-decline time of the end-plate current increases from about 0.6 msec to about 1.6 msec.3. It is suggested that the stability of receptor-mediator complex is affected by the membrane potential.
D000818:Animals; D001001:Anura; D004594:Electrophysiology; D005990:Glycerol / Q000494:pharmacology; D066298:In Vitro Techniques; D008564:Membrane Potentials; D009469:Neuromuscular Junction / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D011984:Sensory Receptor Cells / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D012964:Sodium; D005990:Glycerol; D011188:Potassium
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