Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas.
The sex-linked electrophoretic variants A and B of glucose-6-phosphate dehydrogenase were studied in 86 samples of myometrium and 27 leiomyomas from five heterozygous women. All but one sample of myometrium had both A and B bands in equal or nearly equal amounts. In contrast to this, all of the leiomyomas had either an A band or a B band. Both A and B tumors were found in all uteri. These findings are consistent with the hypothesis that these tumors arose from single cells.
D000328:Adult; D004586:Electrophoresis; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007889:Leiomyoma / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*; D012728:Sex Chromatin; D014594:Uterine Neoplasms / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*
D005954:Glucosephosphate Dehydrogenase