Total body scanning with strontium-85 in the diagnosis of metastatic bone disease.
To demonstrate skeletal metastases before radiographic changes were apparent, Sr(85) scans were carried out on 46 patients who complained of sketetal pain but whose radiographs were negative. Positive scans were obtained in 34 patients, 20 of whom were subsequently shown to have metastases; three did not have skeletal metastases a year or more later; the outcome is unknown in 11 patients. Twelve patients had negative scans: three ultimately developed metastases, six did not, and three were inconclusive. Autoradiographs demonstrated Sr(85) concentrations in areas of reactive osteogenesis.Although not specific for skeletal metastases, Sr(85) scans are most helpful in substantiating this diagnosis when radiographic changes are absent.
D001345:Autoradiography; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D010006:Osteoblasts; D010012:Osteogenesis; D011877:Radionuclide Imaging; D013325:Strontium Isotopes
D013325:Strontium Isotopes
J Can Assoc Radiol. 1964 Jun;15:53-73
14173306
JAMA. 1964 Apr 6;188:1-4
14107206
J Clin Invest. 1963 Jul;42:1095-1104
14015769
Proc Soc Exp Biol Med. 1957 Jun;95(2):386-91
13441748
Q J Med. 1960 Jan;29:85-111
13824642
Can Med Assoc J. 1962 Aug 25;87:371-7
13913237
Health Phys. 1963 May;9:529-35
13979149
Acta radiol. 1961 Feb;55:119-28
13710135
Pediatr Akus Ginekol. 1963;1:9-13
13969224