Effect of gamma radiation on dietary and hormonal induction of enzymes in rat liver.
The dietary induction of serine dehydrase, produced by the oral intubation of hydrolyzed casein to protein-depleted rats, is markedly inhibited by doses of gamma-radiation of 400 roentgens or higher provided the irradiation is given within an hour after the initial dose of casein. If the irradiation is delayed until 7 hours after the initial dose of casein, induction is not inhibited. In contrast, the cortisone induction of tyrosine alpha-ketoglutarate transaminase is not inhibited by doses of gamma-radiation up to 3200 roentgens; in some instances hormonal induction of this enzyme appears to be enhanced by irradiation.
D000315:Adrenalectomy; D000818:Animals; D002364:Caseins / Q000378:metabolism*; D003348:Cortisone / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology; D004044:Dietary Proteins; D006836:Hydro-Lyases / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology* / Q000528:radiation effects; D011830:Radiation Effects; D051381:Rats; D000637:Transaminases / Q000378:metabolism*
D002364:Caseins; D004044:Dietary Proteins; D003609:Dactinomycin; D000637:Transaminases; D006836:Hydro-Lyases; D003348:Cortisone; D006854:Hydrocortisone