The mechanism of plasma albumin loss in carcinoma of the cecum.
Investigation of hypoalbuminemia in an elderly woman with a large papillary adenocarcinoma of the cecum revealed that the hypoproteinemia was due to excessive loss of plasma albumin into the intestinal tract. Results of studies on this patient and analysis of published reports suggest that several factors were involved in the loss of albumin from the neoplasm, namely, the size and location of the tumour, absence of normal surface epithelium, presence of exudate on the surface of the tumour due to tumour necrosis and secondary infection, and bleeding from damaged vessels near the surface of the tumour.
D000230:Adenocarcinoma; D000368:Aged; D001796:Blood Protein Disorders / Q000209:etiology; D002430:Cecal Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated
D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated
Can J Surg. 1958 Apr;1(3):226-9
13523477
Circ Res. 1961 Mar;9:349-57
13684681
N Engl J Med. 1962 Mar 29;266:652-60
14451526
J Lab Clin Med. 1963 Feb;61:317-23
14022781
Am J Dig Dis. 1963 Oct;8:877-81
14077602
Pediatrics. 1964 Nov;34:636-48
14227643
Acta Med Scand. 1964 Dec;176:787-99
14259918
Gastroenterology. 1960 May;38:769-76
14406821