Inhibitory oxidation products of indole-3-acetic acid: enzymic formation and detoxification by pea seedlings.
Extracts of etiolated pea seedlings oxidize indole-3-acetic acid, a plant auxin, to 3-hydroxymethyloxindole. At physiological pH this compound is dehydrated to 3-methyleneoxindole, a highly reactive sulfhydryl reagent and inhibitor of cell growth. 3-Methlyeneoxindole is in turn detoxified by an enzymatic, triphosphopyridine nucleotide-linked reduction to 3-methyloxindole, a nontoxic compound. These enzymatic conversions may be responsible for some of the responses to auxin, particularly sensitivity to its inhibitory effects on growth.
D000963:Antimetabolites; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007210:Indoleacetic Acids / Q000378:metabolism*; D010084:Oxidation-Reduction; D010937:Plant Growth Regulators / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*
D000963:Antimetabolites; D007202:Indicators and Reagents; D007210:Indoleacetic Acids; D010937:Plant Growth Regulators