Electron-opaque, lipid-containing bodies in mouse liver at early intervals after partial hepatectomy and sham operation.
The appearance and distribution of electron-opaque, lipid-containing bodies have been studied in liver of adult male mice of the C3H strain. The mice were either partially hepatectomized or sham-operated, and the liver was fixed in Veronal acetate-buffered 2 per cent osmium tetroxide at various postoperative intervals (10, 20, 40, 60, and 120 minutes). Normal, non-operated mice served as controls. As early as 10 minutes after both sham operation and partial hepatectomy, lipid-containing bodies have been observed, not only in the cytoplasm of hepatic parenchymal cells, but also in the space of Disse. At the very early postoperative intervals studied, minute lipid bodies are repeatedly found to be more numerous in the space of Disse than at later intervals. It is suggested that the lipid-containing bodies enter the parenchymal cell from the circulation. At the cell membrane, numerous invaginations, each containing a lipid body, have been observed; this suggests that the lipid bodies enter the hepatic parenchymal cells by the process of pinocytosis.The fact that only hepatic parenchymal cells contain the lipid bodies, whereas von Kupffer, endothelial lining, and Ito's fat-storing cells do not, may indicate a specific lipid mobilization response on the part of the cells of the hepatic parenchyma.
D000818:Animals; D006498:Hepatectomy; D008055:Lipids; D008099:Liver / Q000166:cytology*; D008115:Liver Regeneration; D051379:Mice; D008854:Microscopy, Electron; D010873:Pinocytosis
D008055:Lipids
J Biophys Biochem Cytol. 1959 May 25;5(3):373-84
13664677
J Cell Biol. 1963 Oct;19:139-57
14069791
Am J Physiol. 1958 Nov;195(2):301-10
13583166
J Cell Biol. 1963 May;17:375-412
13944428
Perspect Biol Med. 1960;3:491-527
14398947
J Cell Biol. 1963 Apr;17:19-58
13975866
Int Rev Cytol. 1963;15:245-300
14283580
J Histochem Cytochem. 1964 Feb;12:57-71
14187313
Physiol Rev. 1960 Oct;40:677-733
13730906
Physiol Rev. 1958 Oct;38(4):585-630
13590931
Z Zellforsch Mikrosk Anat. 1963;59:326-57
13999052
J Cell Biol. 1964 May;21:233-44
14153484
J Lipid Res. 1960 Jul;1:326-31
13834138
J Cell Biol. 1963 Apr;17:208-12
13986422
J Natl Cancer Inst. 1955 Apr;15(5, Suppl.):1475-503
13243087
J Clin Invest. 1956 Feb;35(2):206-12
13286339
J Biophys Biochem Cytol. 1956 Nov 25;2(6):799-802
13398447
Anat Rec. 1959 Jul;134:365-77
14406269
Am J Physiol. 1960 Jun;198:1326-8
13794778
Cancer Res. 1959 Nov;19:997-1009
14434277
Am J Physiol. 1961 Aug;201:227-30
13710667
Anat Rec. 1961 Sep;141:1-9
14471914