Effect of dietary factors upon the resistance of albino mice to experimental infection with Mycobacterium tuberculosis.
Layton, Herbert W. (Northwestern University Medical School, Chicago, Ill.), and Guy P. Youmans. Effect of dietary factors upon the resistance of albino mice to experimental infection with Mycobacterium tuberculosis. J. Bacteriol. 90:958-964. 1965.-Each of the major nutritional components of a synthetic diet was quantitatively altered to determine its effect upon the resistance of albino mice to infection with Mycobacterium tuberculosis. The animals were challenged after the first 2 weeks of feeding, and the percentage that survived acute death was determined statistically. The level of protein which provided the greatest percentage of survival was 30%; increases or decreases from this level were detrimental. The optimal fat level was found to be 5% for either corn oil or coconut oil. Survival decreased when greater amounts of oil were added, and this effect was especially marked for 40% coconut oil. Vitamin A enhanced survival when increased from the normal level of 20,000 units per kg of diet to 160,000 units, but further increases were harmful. An amount of 75 g/kg of a vitamin B complex mixture afforded optimal resistance, but 25-g shifts in either direction lowered this resistance. Vitamin K-free diets resulted in high levels of survival, and addition of the vitamin resulted in proportional decreases in resistance.
D000818:Animals; D004041:Dietary Fats; D004044:Dietary Proteins; D051379:Mice; D014376:Tuberculosis; D014801:Vitamin A / Q000494:pharmacology*; D014803:Vitamin B Complex / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology*
D004041:Dietary Fats; D004044:Dietary Proteins; D014801:Vitamin A; D014803:Vitamin B Complex; D014812:Vitamin K
J Bacteriol. 1955 Oct;70(4):415-9
13263310
J Nutr. 1957 Aug 10;62(4):601-19
13449650
J Am Diet Assoc. 1954 Jan;30(1):17-20
13117614
J Bacteriol. 1954 Jun;67(6):731-3
13174504
J Exp Med. 1953 Aug;98(2):145-55
13069657
Tubercle. 1950 Sep;31(9):198-209
15443058
Am Rev Respir Dis. 1962 Nov;86:733-7
13955213
J Exp Med. 1955 Jan 1;101(1):59-84
13211927
Biochem J. 1947;41(1):97-100
16748127
Am Rev Respir Dis. 1964 Apr;89:575-8
14139325
J Nutr. 1961 Sep;75:51-60
13730596
J Immunol. 1957 May;78(5):318-29
13449321