Collagen defect induced by penicillamine.
Collagen synthesis, as judged by the accumulation of collagen in a subcutaneous, induced granuloma, was significantly decreased by penicillamine. Penicillamine also caused a marked increase in the amount of soluble collagen in skin and a sharp drop in insoluble material. These findings, which reflect an abnormal pattern of collagen metdbolism, are accompanied by an inhibition of wound-healing and by skin fragility.
D003094:Collagen / Q000378:metabolism*; D006099:Granuloma / Q000378:metabolism*; D010396:Penicillamine / Q000494:pharmacology*; D011736:Pyridoxine / Q000494:pharmacology; D012867:Skin / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects
D003094:Collagen; D010396:Penicillamine; D011736:Pyridoxine