Actinomycin D and Hydrocortisone: intracellular binding in rat liver.
DNA was found to be the major intracellular binding site for labeled actinomycin D administered in vivo. In analogous studies, hydrocortisone did not bind to nuclear structures. Furthermore, following the administration of actinomycin D, a highly positive correlation was found between the RNA content of the nucleus and the ability of the nucleus to synthesize RNA.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D011232:Chemical Precipitation; D004247:DNA / Q000096:biosynthesis*; D003609:Dactinomycin / Q000378:metabolism*; D006854:Hydrocortisone / Q000378:metabolism*; D008099:Liver / Q000166:cytology* / Q000378:metabolism*; D009705:Nucleosides / Q000096:biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014316:Tritium
D009705:Nucleosides; D014316:Tritium; D003609:Dactinomycin; D012313:RNA; D004247:DNA; D006854:Hydrocortisone