Metabolic clearance rate of radioiodinated human growth hormone in man.
The nature of the disappearance of radioiodinated human growth hormone (HGH) from plasma has been reexamined. The metabolic clearance rate (MCR) was determined both from single injection and constant infusion studies. After single injection of highly purified radioiodinated HGH, the disappearance curve remained multiexponential during the period of study (4 hr). The shape of the curve was independent of the growth hormone preparation used. Similar disappearance curves were obtained with unlabeled HGH.MCR values calculated from constant infusion studies were 203 +/-7.8 liters/day per m(2) and values derived from single injection studies agreed closely with this. The multiexponential nature of the disappearance curve does not permit meaningful calculation of volume of distribution or half-time of disappearance.
D000328:Adult; D011232:Chemical Precipitation; D002845:Chromatography; D003201:Computers; D004586:Electrophoresis; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007456:Iodine Isotopes; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011863:Radioimmunoassay
D007456:Iodine Isotopes; D013006:Growth Hormone
Endocrinology. 1965 Sep;77(3):563-73
4953799
J Clin Endocrinol Metab. 1965 Dec;25(12):1599-608
5845860
J Clin Endocrinol Metab. 1963 Dec;23:1285-97
14087609
Nature. 1965 Jul 17;207(994):298-9
5886224
Nature. 1966 Jun 18;210(5042):1288-9
5967817
Science. 1957 May 3;125(3253):883-4
13421687
J Clin Invest. 1968 Jan;47(1):38-47
16695945
J Endocrinol. 1961 Dec;23:285-90
14004646
J Clin Endocrinol Metab. 1966 Oct;26(10):1173-7
5923700
Proc Soc Exp Biol Med. 1966 Jan;121(1):173-7
5902925
J Clin Invest. 1967 Jun;46(6):953-9
6026100
J Endocrinol. 1966 Feb;34(2):139-46
5901832
Anal Biochem. 1968 Nov;26(2):207-9
5758040
J Endocrinol. 1967 Aug;38(4):451-4
6030010
J Clin Endocrinol Metab. 1964 Jun;24:501-5
14187288
Can J Biochem Physiol. 1961 Nov;39:1659-68
14007012
Folia Endocrinol. 1962 Dec;15:721-9
14022723
J Lab Clin Med. 1967 Nov;70(5):820-30
6055766
Endocrinology. 1962 Apr;70:459-64
14496440
Biochem J. 1963 Oct;89:114-23
14097352
Biophys J. 1962 May;2:275-87
13867975
J Clin Invest. 1962 Feb;41:262-8
14483925
Science. 1967 Dec 22;158(3808):1570-2
6060361