DNA: reaction with chloroquine.
Diflerence spectrophotometry shows that double-stranded DNA produces mnarked changes in the absorption spectrum of chloroquine; only minor changes occur with single-stranded DNA. A DNA-chloroquine complex was demonstrated to sediment in the analytical ultracentrifuge. Chloroquine strongly elevated the thermal dissociation temperature, T(m), of DNA. It is concluded that the drug forms a complex with DNA by ionic interaction and stabilizes the helix.
D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D002738:Chloroquine; D004247:DNA; D006493:Heparin; D006358:Hot Temperature; D066298:In Vitro Techniques; D013057:Spectrum Analysis; D014461:Ultracentrifugation
D002738:Chloroquine; D006493:Heparin; D004247:DNA