Antigenicity of polypeptides (poly alpha amino acids). XV. Studies on the immunogenicity of synthetic polypeptides in mice.
The response of mice to synthetic linear polypeptides of known composition but random sequence has been studied. Neither Swiss mice nor a number of inbred strains could respond to copolymers of only 2 amino acids (G(60)L(40), G(60)A(40), G(90)T(10)). Upon introduction of as little as 4 mole per cent of a third amino acid, good immune responses were obtained, regardless of the nature of the third amino acid. The level of the immune response to a series of glu-lys-ala polymers increased with increasing alanine content of the polymer.
D000596:Amino Acids; D000818:Animals; D000941:Antigens; D051379:Mice; D010455:Peptides
D000596:Amino Acids; D000941:Antigens; D010455:Peptides
Biochem J. 1964 Dec;93(3):566-72
5839191
J Immunol. 1954 May;72(5):368-75
13163410
J Immunol. 1956 Jul;77(1):52-60
13346095
J Exp Med. 1958 Jul 1;108(1):37-51
13549640
J Immunol. 1962 Mar;88:320-9
13910995
J Exp Med. 1962 Oct 1;116:521-34
13933994
Immunology. 1963 Sep;6:421-33
14069718
J Exp Med. 1965 Mar 1;121:339-49
14271319
J Immunol. 1963 Mar;90:388-92
14051871
J Immunol. 1963 Mar;90:393-8
14051872
Adv Protein Chem. 1958;13:243-492
14404711