Protein synthesis by ribosomes from heart muscle: effect of insulin and diabetes.
Incorporation of phenylalanine into protein by ribosomes from the heart muscle of rats is decreased when the ribosomes are from alloxan-diabetic animals. Protein synthesis is increased when the ribosomes are obtained from nondiabetic animals I hour after treatment with insulin. The change due to insulin appears to be an alteration in the function of the ribosome.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D010649:Phenylalanine / Q000378:metabolism; D014176:Protein Biosynthesis; D012343:RNA, Transfer; D051381:Rats; D012270:Ribosomes
D007328:Insulin; D010649:Phenylalanine; D012343:RNA, Transfer