Alcohol metabolism: role of microsomal oxidation in vivo.
A role for microsomal alcohol oxidation cannot be demonstrated in vivo. Factors affecting microsomal drug hydroxylations had no effect on alcohol metabolism in the rat in vivo. The compound SKF 525-A which inhibits, and chronic phenobarbital treatment which enhances microsomal drug hydroxylations did not alter alcohol oxidation.
D000438:Alcohols / Q000378:metabolism*; D000818:Animals; D002247:Carbon Isotopes; D000431:Ethanol / Q000378:metabolism; D000432:Methanol / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats
D000438:Alcohols; D002247:Carbon Isotopes; D000431:Ethanol; D011335:Proadifen; D000432:Methanol; D010634:Phenobarbital