The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004357:Drug Synergism; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy*; D008239:Lysine / Q000378:metabolism; D008297:Male; D051379:Mice; D008937:Mitomycins / Q000627:therapeutic use*; D009026:Mortality; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009368:Neoplasm Transplantation; D009963:Orotic Acid / Q000378:metabolism; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012510:Sarcoma 180 / Q000188:drug therapy*; D013866:Thioguanine / Q000627:therapeutic use*; D013936:Thymidine / Q000378:metabolism; D013937:Thymidine Kinase / Q000378:metabolism
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D008937:Mitomycins; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D009963:Orotic Acid; D013937:Thymidine Kinase; D013866:Thioguanine; D008239:Lysine; D005472:Fluorouracil; D013936:Thymidine