Dual site of action of phenoxybenzamine in the cat's spleen; blockade of alpha-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D002415:Cats; D066298:In Vitro Techniques; D009448:Neurochemistry; D009638:Norepinephrine / Q000378:metabolism*; D010477:Perfusion; D010643:Phenoxybenzamine / Q000494:pharmacology*; D011984:Sensory Receptor Cells / Q000187:drug effects*; D013154:Spleen / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013565:Sympatholytics / Q000494:pharmacology*; D014655:Vascular Resistance
D013565:Sympatholytics; D010643:Phenoxybenzamine; D009638:Norepinephrine