The incorporation of isotopic carbon (14C) into the cerebral glycogen of rabbits.
1. The incorporation of (14)C into the brain glycogen of conscious rabbits with labelled glucose, bicarbonate and glutamate as precursors has been studied. 2. Substantial incorporation from all these precursors was demonstrated after an interval of 5hr. from their injection. 3. With [(14)C]glucose maximal incorporation occurred at about 8hr. from the time of injection. 4. Hydrocortisone led to increased incorporation of (14)C from labelled glucose. 5. Some comparisons between the turnover of brain glycogen and that of skeletal and cardiac muscle are reported.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D006003:Glycogen / Q000096:biosynthesis*; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits
D001639:Bicarbonates; D002247:Carbon Isotopes; D005971:Glutamates; D006003:Glycogen; D005947:Glucose; D006854:Hydrocortisone; D004837:Epinephrine