Primary immune reactions in organ cultures.
Primary immune reactions were initiated and maintained in vitro. Spleen explants from mice treated with either phytohemagglutinin or adjuvant were stimulated to form hemagglutinins and hemolysins, whereas no treatment of spleen donors was necessary to invoke a "graft-versus-host" response which led to specific splenomegly.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000502:physiology*; D002454:Cell Differentiation; D046508:Culture Techniques; D004912:Erythrocytes; D006384:Hemagglutination; D037102:Lectins / Q000494:pharmacology; D008221:Lymphoid Tissue / Q000166:cytology; D051379:Mice; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D014181:Transplantation Immunology
D000276:Adjuvants, Immunologic; D037102:Lectins