Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.
Glucose, sorbitol, fructose, and inositol are present in peripheral nerve and spinal cord. Marked elevation of these substances occurs in these tissues in mildly diabetic animals. These alterations provide biochemical mechanisms which could be significant in the etiology of diabetic neuropathy.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000209:etiology; D005632:Fructose / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007294:Inositol / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D051381:Rats; D013012:Sorbitol / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D005632:Fructose; D007294:Inositol; D013012:Sorbitol; D005947:Glucose