Hyperbaric oxygenation: the eye as a limiting factor.
In dogs exposed to 100 percent oxygen at 3 atmospheres absolute pressure for more than 4 hours, a characteristic retinal lesion, manifested as the cytoid-body change, occurs. The selectivity of this injury suggests that the eye may be used as a sensitive indicator and as a site for study of oxygen toxicity. The cytoid body, an entity of disputed genesis, was produced experimentally for the first time.
D000818:Animals; D004285:Dogs; D004596:Electroretinography; D005131:Eye Injuries / Q000209:etiology*; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D066298:In Vitro Techniques; D010100:Oxygen / Q000633:toxicity; D012160:Retina / Q000187:drug effects*
D010100:Oxygen