Phenylketonuria: limit in capacity of pre-weanling rats to oxidize beta-phenyllactate and other alpha-hydroxy acids.
In comparison with mature animals, pre-weanling rats have markedly higher and longer lasting serum levels of beta-phenyllactate following the intraperitoneal injection of a moderate dose. A corresponding age-dependent difference in the rate of oxidation of beta-phenyllactate and other alpha-hydroxy acids was observed in experiments with homogenates and supernatant fractions of rat kidney.
D000818:Animals; D001769:Blood; D002208:Caproates / Q000378:metabolism*; D002210:Caprylates / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D010661:Phenylketonurias / Q000378:metabolism*; D010667:Phenylpyruvic Acids / Q000378:metabolism*; D051381:Rats; D014631:Valerates / Q000378:metabolism*
D002208:Caproates; D002210:Caprylates; D007773:Lactates; D010667:Phenylpyruvic Acids; D014631:Valerates