Effect of actinomycin D on immune antibody, normal antibody, and complement.
Muschel, Louis H. (University of Minnesota, Minneapolis), Jean L. Jackson, and Karen Schmoker. Effect of actinomycin D on immune antibody, normal antibody, and complement. J. Bacteriol. 91:270-272. 1966.-The effect of actinomycin D on the immune response, when the antibiotic was administered to rabbits simultaneously with antigen, and its effect on naturally occurring levels of antibody and complement were determined. Those amounts of the antibiotic that effected a significant suppression of the immune response against deliberately injected antigens did not cause a decline in levels of naturally occurring antibody. Complement titers were also refractory to the antibiotic.
D000818:Animals; D000937:Antigen-Antibody Reactions; D003168:Complement Fixation Tests; D003165:Complement System Proteins; D003609:Dactinomycin / Q000494:pharmacology*; D004731:Endotoxins; D007106:Immune Sera; D066298:In Vitro Techniques; D010047:Ovalbumin; D011817:Rabbits; D012485:Salmonella typhi
D004731:Endotoxins; D007106:Immune Sera; D003609:Dactinomycin; D010047:Ovalbumin; D003165:Complement System Proteins