Puromycin effect on successive phases of memory storage.
Mice injected bitemporally with puromycin 5 hours before training learned to escape or to avoid shock by choosing the correct limb of a Y-maze. When retested 15 minutes after training they had normal retention. In the ensuing 2(3/4) hours the animals injected with puromycin, unlike the controls, showed a progressive decrease of savings to less than 7 percent.
D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal; D008568:Memory; D051379:Mice; D011600:Psychopharmacology; D011691:Puromycin / Q000494:pharmacology*
D011691:Puromycin