Hemolysin of Mycoplasma pneumoniae: tentative identification as a peroxide.
Mycoplasma pneumoniae produces a soluble hemolysin active against guinea pig erythrocytes. This hemolysin appears to be a peroxide, since catalase or peroxidase inhibits its activity. The action of catalase and peroxidase is specific, since heating the enzymes abolishes their effect on the hemolysin. In addition, 3-amino- 1,2,4-triazole, a potent inhibitor of catalase, reverses the inhibitory effect of the enzyme. The hemolysin of M. laidlawii is also a peroxide. The hemolysins of M. pneumoniae and M. laidlawii seem unique for microbial organisms since the bacterial hemolysins which have been described have been protein or lipid in nature.
D000818:Animals; D002374:Catalase / Q000494:pharmacology; D046508:Culture Techniques; D004912:Erythrocytes; D006168:Guinea Pigs; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D009174:Mycoplasma / Q000378:metabolism*; D010545:Peroxides / Q000096:biosynthesis*; D012137:Respiratory System / Q000187:drug effects; D014774:Virulence
D006460:Hemolysin Proteins; D010545:Peroxides; D002374:Catalase