Actinomycin D: inhibition of protein synthesis unrelated to effect on template RNA synthesis.
Incubation of sarcoma-37 ascites cells in vitro with actinomycin D resulted in inhibition of synthesis of nuclear and cytoplasmic proteins. The overall inhibition could be prevented or relieved by glucose; it is thus unrelated to breakdown of template RNA.
D000818:Animals; D002247:Carbon Isotopes; D046508:Culture Techniques; D003609:Dactinomycin / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D008239:Lysine / Q000378:metabolism; D014176:Protein Biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D011874:Radiometry; D012511:Sarcoma 37 / Q000378:metabolism*
D002247:Carbon Isotopes; D012334:RNA, Neoplasm; D003609:Dactinomycin; D005947:Glucose; D008239:Lysine