Chloroquine: physiological basis of drug resistance in Plasmodium berghei.
Mouse erythrocytes, parasitized by chloroquine-sensitive plasmodia, concentrate this drug in vivo to levels over twice as high as erythrocytes parasitized by chloroquine-resistant plasmodia; nonparasitized red cells accumulate little chloroquine. Selective toxicity of this drug may depend upon a special drug-concentrating mechanism of plasmodic impairment of such mechanism.
D000818:Animals; D002247:Carbon Isotopes; D002738:Chloroquine / Q000378:metabolism* / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial / Q000502:physiology*; D004912:Erythrocytes / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010961:Plasmodium / Q000187:drug effects*; D011796:Quinacrine / Q000627:therapeutic use; D011803:Quinine / Q000627:therapeutic use; D011874:Radiometry; D013154:Spleen
D002247:Carbon Isotopes; D002738:Chloroquine; D011803:Quinine; D011796:Quinacrine