Staphylococcal alpha-toxin: effects on artificial lipid spherules.
Staphylococcal alpha-toxin induces the release of previously sequestered anions or glucose from artificial phospholipid spherules, an effect abolished by specific antitoxin. Alphatoxin resembles streptolysin S in releasing anions or glucose from spherules prepared without cholesterol, and can be distinguished from the membrane-active polyene amphotericin B, which preferentially disrupts spherules containing cholesterol. It may affect biological structures by a similiar interaction with membrane phospholipids.
D000666:Amphotericin B / Q000494:pharmacology*; D002784:Cholesterol / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D007477:Ions; D008962:Models, Theoretical; D010743:Phospholipids; D013210:Staphylococcus; D013301:Streptolysins / Q000494:pharmacology*; D014118:Toxins, Biological / Q000494:pharmacology*
D007477:Ions; D010743:Phospholipids; D013301:Streptolysins; D014118:Toxins, Biological; D000666:Amphotericin B; D002784:Cholesterol; D005947:Glucose