Formation of glucose from hexoses, pentoses, polyols and related substances in kidney cortex.
1. Slices of rat kidney cortex, on incubation in a saline medium, formed d-glucose from the following substances: d-fructose, d-galactose, d-mannose, l-sorbose, l-arabinose, d-xylose, glycerol, myo-inositol, l-iditol, sorbitol, xylitol, ribitol, methylglyoxal, dihydroxyacetone, l-glyceraldehyde, d-glyceraldehyde, dl-glyceraldehyde, dl-glycerate. Values for the rates of glucose formation from these precursors are given. 2. No glucose was formed from l-rhamnose, d-arabitol, d-arabinose, d-ribose, l-fucose, d-lyxose, mannitol, dulcitol, d-glucuronate, propane-1,2-diol and propan-2-ol. 3. The pathways of glucose formation from the various precursors are discussed (Scheme 1). 4. l-Glyceraldehyde inhibited the formation of glucose from d-glyceraldehyde.
D000438:Alcohols / Q000378:metabolism*; D000818:Animals; D005943:Gluconeogenesis; D005947:Glucose / Q000096:biosynthesis*; D005985:Glyceraldehyde / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism*; D066298:In Vitro Techniques; D007659:Ketones / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D010429:Pentoses / Q000378:metabolism*; D011422:Propionates / Q000378:metabolism; D051381:Rats; D013012:Sorbitol / Q000378:metabolism
D000438:Alcohols; D006601:Hexoses; D007659:Ketones; D010429:Pentoses; D011422:Propionates; D005985:Glyceraldehyde; D013012:Sorbitol; D005947:Glucose; D005990:Glycerol