Radiosensitization of X chromosome of Chinese hamster cells related to incorporation of 5-bromodeoxyuridine.
Selective incorporation of 5-bromodeoxyuridine into the late replicating arm of the X chromosome of Chinese hamister cells cultured in vitro caused a selective radiosensization of the arm to ionizing radiation. Radiation damage was observed as chromosomal aberrations, and incorporation was studied by using tritiated 5-bromodeoxyuridine.
D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism*; D002869:Chromosome Aberrations / Q000209:etiology*; D025063:Chromosome Disorders; D002875:Chromosomes / Q000528:radiation effects*; D006224:Cricetinae; D046508:Culture Techniques; D011831:Radiation Genetics; D011874:Radiometry; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D001973:Bromodeoxyuridine; D013936:Thymidine