Puromycin and cycloheximide: different effects on hippocampal electrical activity.
Abstract. Mice were injected in the temporal region of the brain with cycloheximide or puromycin; both agents markedly inhibit protein synthesis in the brain. Recordings of electrical activity were made in the hippocampal region 5 hours after injection of these drugs. The amplitude and frequency observed in records from mice injected with cycloheximide were indistinguishable from those injected with saline alone. Records from puromycin-injected mice were strikingly abnormal. This finding may contribute to the differences in behavioral effects of intracerebral injections of the two inhibitors of protein synthesis studied.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology; D004569:Electroencephalography; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D051379:Mice; D011506:Proteins; D011691:Puromycin / Q000494:pharmacology*
D000935:Antifungal Agents; D011506:Proteins; D011691:Puromycin; D003513:Cycloheximide