Aminooxyacetic acid: interactions with gamma-aminobutyric acid and the blood-brain barrier.
The hypothesis that the administration of aminooxyacetic acid, a competitive inhibitor of aminobutyrate aminotransferase, might allow gamma-aminobutyric acid to cross the blood-brain barrier was tested by analyzing the brains of rats for this compound after intraperitoneal injection of aminooxyacetic acid, or a mixture of both acids, and by observing behavioral and physiological changes in cats after similar drug administrations. The results do not support the postulate that gamma-aminobutyric acid enters the brain more readily after administration of aminooxyacetic acid.
D000085:Acetates / Q000494:pharmacology*; D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002415:Cats; D004569:Electroencephalography; D051381:Rats; D000637:Transaminases
D000085:Acetates; D000613:Aminobutyrates; D000637:Transaminases