Drug addiction, psychotic illness and brain self-stimulation: effective treatment and explanatory hypothesis.
Similarities between drug addiction and psychotic illness suggested that drug addicts could be treated with intensive ECT and phenothiazine drugs, a therapeutic approach effective in more serious psychotic illnesses.The use of this intensive treatment method is described in six drug addicts. Successful results were achieved in four patients who have been followed up for two to five years. The treatment program, the preliminary investigations and the follow-up procedures are described.Particular reference is made to the brain self-stimulation studies of Olds and others in animals, and those of Heath in man. A hypothesis is advanced to explain the various aspects of the clinical picture in both psychotic illness and drug addiction.The intensive method of treatment should be considered for drug addicts whose prognosis is otherwise poor. Further investigations along the lines of the proposed hypothesis might be profitable in other types of abnormal and maladaptive behaviour.
D000328:Adult; D000437:Alcoholism; D001463:Barbiturates / Q000009:adverse effects; D002746:Chlorpromazine / Q000627:therapeutic use*; D004565:Electroconvulsive Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008032:Limbic System; D008297:Male; D008568:Memory; D008614:Meperidine / Q000009:adverse effects; D008875:Middle Aged; D010640:Phenothiazines / Q000009:adverse effects; D011604:Psychoses, Alcoholic; D011605:Psychoses, Substance-Induced; D019966:Substance-Related Disorders / Q000628:therapy*
D001463:Barbiturates; D010640:Phenothiazines; D008614:Meperidine; D002746:Chlorpromazine