Rapid and marked inhibition of rat-liver RNA polymerase by aflatoxin B-1.
From 15 minutes to 2 hours after the administration of aflatoxin B(1) invivo there is a 35-to 70-percent inhibition of DNA-directed RNA synthesis. The inhibition was reversed 12 and 24 hours later.
D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D003597:Cytosine Nucleotides / Q000378:metabolism*; D004798:Enzymes / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009713:Nucleotidyltransferases / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014316:Tritium
D000348:Aflatoxins; D003597:Cytosine Nucleotides; D004798:Enzymes; D000644:Quaternary Ammonium Compounds; D014316:Tritium; D012313:RNA; D009713:Nucleotidyltransferases