Stimulation of the proliferation of cortical neurons by prenatal treatment with growth hormone.
Subcutaneous or intravenous injections daily of purified bovine pituitary growth hormone into pregnant rats from the 7th till the 20th day of pregnancy (total dose 36 mg) resulted in offspring with unchanged body weight but with significant increases in brain weight, brain DNA content, cortical cell density, and ratio of neurons to glia.
D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects* / Q000196:embryology*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange; D009474:Neurons / Q000187:drug effects*; D009929:Organ Size; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats
D013006:Growth Hormone; D004247:DNA