N-cyclohexyl linoleamide: metabolism and cholesterol-lowering effect in rats.
More than half of orally administered N-cyclohexyl linoleamide-car-boxyl-C(14) yl-CI was recovered from feces of rats, and 30 to 50 percent of the absorbed carbon-14 activity was excreted in urine. N-Cyclohexyl linoleamide had an inhibitory eflect on the absorption of cholesterol from the thoracic duct and caused a decrease in the deposition of cholesterol in the livers of rats that had been fed cholesterol.
D000577:Amides / Q000378:metabolism; D000818:Animals; D002247:Carbon Isotopes / Q000652:urine; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D008041:Linoleic Acids / Q000378:metabolism* / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats
D000577:Amides; D002247:Carbon Isotopes; D008041:Linoleic Acids; D002784:Cholesterol