The influence of cortisone on experimental viral infection. 8. Suppression by cortisone of interferon formation in mice injected with Newcastle disease virus.
The administration, of 5.0 mg of cortisone 6 to 24 hr prior to the intravenous injection of mice with NDV was associated with a marked reduction in the interferon response as measured in serum and spleen. Reduced concentrations of interferon following cortisone pretreatment were demonstrable from 6 to 16 hr following injection of virus.
D000818:Animals; D001769:Blood; D003348:Cortisone / Q000494:pharmacology*; D046508:Culture Techniques; D007372:Interferons / Q000096:biosynthesis*; D008099:Liver; D051379:Mice; D009521:Newcastle Disease; D009522:Newcastle disease virus; D013154:Spleen
D007372:Interferons; D003348:Cortisone