The effect of oligomycin and some nitrophenols on acid secretion and oxygen uptake by gastric mucosa of the frog.
1. The ability of the three nitrophenols, m-nitrophenol, p-nitrophenol and 2,4-dinitrophenol, to inhibit acid secretion and stimulate oxygen uptake by gastric mucosa paralleled their extent of dissociation at physiological pH.2. Oligomycin inhibited oxygen uptake by gastric mucosa, and showed a tendency to inhibit acid secretion.3. 2,4-dinitrophenol lowered the value of the ratio between acid secretion and the associated oxygen uptake. Oligomycin did not affect the value of this ratio.4. It would appear that a non-phosphorylated high-energy intermediate of oxidative phosphorylation might be involved in acid secretion by gastric mucosa.
D000818:Animals; D001001:Anura; D004594:Electrophysiology; D005750:Gastric Juice / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism*; D009596:Nitrophenols / Q000494:pharmacology*; D009840:Oligomycins / Q000494:pharmacology*; D010085:Oxidative Phosphorylation; D010092:Oximetry; D010101:Oxygen Consumption
D009596:Nitrophenols; D009840:Oligomycins