Adenovirus multiplication: inhibition by methisazone.
Methisazone (5 to 40 microM) inhibited the multiplication of types 3, 7, 9, 11, 14, 16, 17, 21, and 28 adenovirus; SV15 (a simian adenovirus) was also inhibited. A study of adenovirus 11 under single-cycle conditions showed that multiplication of the virus, was completely inhibited by 30 microM methisazone when addition of the compound was delayed until 13 hours after infection. A survey showed that the structure-activity relations of the action of methisazone against adenoviruses and pox viruses are similar.
D000256:Adenoviridae / Q000187:drug effects*; D000917:Antibody Formation / Q000187:drug effects*; D000998:Antiviral Agents / Q000494:pharmacology*; D046508:Culture Techniques; D006367:HeLa Cells; D007065:Idoxuridine / Q000494:pharmacology*; D011212:Poxviridae / Q000187:drug effects; D013882:Thiosemicarbazones / Q000494:pharmacology*
D000998:Antiviral Agents; D013882:Thiosemicarbazones; D007065:Idoxuridine