Liver carcinogenesis by diethylnitrosamine in the rat.
Diethylnitrosamine was continuously administered to rats at a dose rate of low toxicity. Ninety-two percent of the animals died with multicentrical hepatocellular carcinomata within a narrow and highly reproducible time interval. Discontinuing the carcinogen during the experiment resulted in a prolonged median time until death, a reduced tumor yield, and a lessened slope of the dose-response curve. Partial hepatectomy after discontinuation of the drug did not change either tumor yield or time of death. The obtained dose-response relationships support the concept that carcinogenic effects of single doses are irreversible and cumulative. Daily, low-dose, total-body x-irradiation had no significant effect on the response of rat liver to the carcinogen.
D000478:Alkylation; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D006498:Hepatectomy; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000209:etiology*; D009026:Mortality; D009602:Nitrosamines / Q000633:toxicity*; D011830:Radiation Effects; D051381:Rats
D002273:Carcinogens; D009602:Nitrosamines