Coagulation studies in massive pulmonary haemorrhage of the newborn.
Coagulation studies were performed on two newborn infants with fatal massive pulmonary haemorrhage. The first showed a reduced level of plasma fibrinogen with defective thrombin-fibrinogen reaction, corrected by protamine, and defective thromboplastin generation. In the second case, a premature infant, the fibrinogen level was normal but there was a severe defect in thromboplastin generation with evidence of an inhibitor. A relationship between the pulmonary haemorrhage and coagulation defects is suggested but not established.
D001778:Blood Coagulation Disorders; D006470:Hemorrhage; D006801:Humans; D006819:Hyaline Membrane Disease; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D007235:Infant, Premature, Diseases; D008171:Lung Diseases; D008297:Male; D001261:Pulmonary Atelectasis