Deficiency of the sixth component of complement in rabbits with an inherited complement defect.
A strain of rabbits with an inherited complement deficiency was shown to lack the sixth component of the hemolytic complement system. A method was elaborated for the partial purification of this component from normal rabbit serum. Upon injection of partially purified rabbit C'6 into C'6-deficient animals, an antibody was obtained which specifically inhibited the hemolytic activity of C'6. The data suggest that C'6-deficient serum either lacks the C'6 molecule or contains it in a chemically modified and inactive form.
D000818:Animals; D001796:Blood Protein Disorders / Q000235:genetics*; D003165:Complement System Proteins; D011817:Rabbits
D003165:Complement System Proteins