Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum.
Serum globulin from donor sheep made nephritic by immunization with glomerular basement membrane and subsequently nephrectomized contained specific kidney-fixing antibody and was capable of inducing an immediate, although transient, glomerulonephritis when injected into unilaterally nephrectomized lambs. This nephritis was characterized by immediate proteinuria, PMN infiltration into the glomerulus, and localization of gammaG- and beta1C-globulins in a linear fashion along the recipients' glomerular capillary walls. The nephritogenic property of the serum could be absorbed in vitro with isolated sheep glomerular basement membranes.
D000818:Animals; D001327:Autoimmune Diseases; D001485:Basement Membrane; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology*; D006967:Hypersensitivity; D008856:Microscopy, Fluorescence; D009392:Nephrectomy; D012712:Serum Globulins; D012756:Sheep
D012712:Serum Globulins