Mammary tumor inhibition and lung adenoma induction by isonicotinic acid hydrazide.
The occurrence of manomary adenocarcinonmas in C3H mice is largely inhibited by prolonged admninistration of 0.1 percent isonicotinic acid hydrazide in drinking water. At the same time that this compound produtced the inhibitory action, it also increased the incidence of pulmonary adenomas.
D000230:Adenocarcinoma / Q000517:prevention & control; D000236:Adenoma / Q000209:etiology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000494:pharmacology; D005260:Female; D007538:Isoniazid / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control*; D051379:Mice; D011379:Prognosis
D002273:Carcinogens; D007538:Isoniazid