Dealkylation studies on inhibited acetylcholinesterase.
1. A rapid method for measuring the rate of dealkylation of organophosporus-inhibited enzymes is described. 2. The dealkylation rates have been measured for acetylcholinesterase inhibited by isopropyl, sec.-butyl, 1,2-dimethylpropyl, 1,2,2-trimethylpropyl and cyclohexyl methylphosphonofluoridate, and by di-isopropyl phosphorofluoridate; they are first-order under the conditions used.
D000110:Acetylcholinesterase; D055598:Chemical Phenomena; D002621:Chemistry; D002800:Cholinesterase Inhibitors; D002845:Chromatography; D007531:Isoflurophate; D007700:Kinetics; D063065:Organophosphonates; D010710:Phosphates
D002800:Cholinesterase Inhibitors; D063065:Organophosphonates; D010710:Phosphates; D007531:Isoflurophate; D000110:Acetylcholinesterase