Advances in the understanding and treatment of head injury.
The author describes his personal involvement in head injury prevention and management over the past 40 years. He reviews the evolution of knowledge concerning the role of increased intracranial pressure, and considers the importance of cerebral vasoparalysis in the production of signs and symptoms following head injury, and the development of methods of recording intracranial pressure continuously, over hours and days.The development of an experimental compression model has led to a fuller understanding of edema of the brain and has provided a means of studying, by light and electron microscopy, the histological changes that result from edema. More recently, analyses of biochemical changes and disturbed membrane function have opened up a new avenue of potential treatment. Moreover, it is now clear that cerebral vascular dilatation and abrupt pressure increase can be produced in the monkey, in over 50% of cases, by lesions in the dorsomedial nucleus of the hypothalamus. Similar lesions may occur in the human and this suggests other therapeutic approaches. There is, then, a genuine hope of a breakthrough in the management of head injuries.
D000818:Animals; D001795:Blood Pressure Determination; D001929:Brain Edema / Q000473:pathology*; D002415:Cats; D006259:Craniocerebral Trauma / Q000517:prevention & control* / Q000628:therapy; D004569:Electroencephalography; D006408:Hematoma, Subdural / Q000473:pathology; D006801:Humans; D007427:Intracranial Pressure; D002546:Ischemic Attack, Transient / Q000188:drug therapy; D009705:Nucleosides / Q000494:pharmacology; D014529:Uridine / Q000494:pharmacology
D009705:Nucleosides; D014529:Uridine