U-21,963, a new antibiotic. II. Isolation and characterization.
The isolation and characterization of antibiotic U-21,963 are discussed. This compound is a highly unsaturated monobasic acid with the molecular formula C(9)H(7)NO(3). The molecular weight is 177. It is dextrorotatory, [alpha](D) = +138 degrees , and has a pK(a) of 5.1. The ultraviolet absorption spectrum, which showed a maximum at 223 mmu (epsilon = 15,115), indicates unsaturation alpha-beta to the carboxyl group, and the infrared spectrum suggests the presence of an acetylenic group. Explosive decomposition of U-21,963 at 97 C conforms with the latter. U-21,963 is relatively insoluble in water, but readily soluble in ethyl alcohol, acetone, and halogenated hydrocarbons.
D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D008970:Molecular Weight; D012997:Solvents; D013053:Spectrophotometry
D000900:Anti-Bacterial Agents; D012997:Solvents