Possible use of phosphohexose isomerase as a preliminary to exfoliative cytology in screening for cervical carcinoma.
The activities of phosphohexose isomerase and 6-phosphogluconate dehydrogenase have been studied in the vaginal fluid of women from the gynaecological departments. Women from these departments gave a very high false positive rate, though no cases of carcinoma in situ were not detected by estimating phosphohexose isomerase levels. It gave considerably better results in malignancy than 6-phosphogluconate dehydrogenase. It is suggested that the use of phosphohexose isomerase might be of value in screening well women during a mass cytology programme.
D003581:Cytodiagnosis; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000032:analysis; D006801:Humans; D008403:Mass Screening; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*; D014621:Vagina / Q000201:enzymology*
D005956:Glucose-6-Phosphate Isomerase