Sleep deprivation and brain acetylcholine.
Rats deprived of D-state sleep (and, to some extent, of slow-wave sleep) for 96 hours show a significant fall in brain acetylcholine in the telencephalon; there were no significant changes in the diencephalon and brain stem. Restraint stress and activity wheel stress produced no significant change in acetylcholine levels in any of these regions; the telencephalic response to sleep deprivation, therefore, cannot be attributed to nonspecific stress. The effects of D-state deprivation and the psychoactive anticholinergic drugs on telencephalic acetylcholine levels are similar.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D008297:Male; D051381:Rats; D012890:Sleep; D013312:Stress, Physiological; D013687:Telencephalon / Q000378:metabolism*
D000109:Acetylcholine