Thiosemicarbazide injection followed by electric shock increases resistance to stress in rats.
Adult rats that had been raised with a minimum of stimulation were injected with thiosemicarbazide, a drug that lowers y-aminobutyric acid concentrations. Fifteen minutes later the animals were given 30 mild electric shocks over a half-hour period. Two. weeks later they were tested for their resistance to gastric ulceration induced by immobilization. The experimental animals showed a much greater resistance to stress than did the appropriate control groups. A replication confirmed the results of the first study.
D000613:Aminobutyrates / Q000378:metabolism; D000818:Animals; D004558:Electric Stimulation; D004597:Electroshock; D007103:Immobilization; D009068:Movement; D051381:Rats; D012663:Semicarbazides / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000209:etiology*; D013312:Stress, Physiological
D000613:Aminobutyrates; D012663:Semicarbazides