Inhibition of drug metabolism. 3. Inhibition of hexobarbital metabolism in the intact rat and in the isolated perfused liver by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and its N-deethylated derivatives.
D000818:Animals; D004798:Enzymes / Q000494:pharmacology*; D006591:Hexobarbital / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000201:enzymology*; D010477:Perfusion; D011335:Proadifen / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*
D004798:Enzymes; D011335:Proadifen; D006591:Hexobarbital