Hemopoietic colony-forming units in regenerating mouse liver: suppression by anticoagulants.
After hepatic injury induced by carbon tetrachloride, mitotically active hematopoietic cells of nonhepatic origin localize in the liver as judged by an increase in colony-forming nodules in the spleens of lethally irradiated recipient mice on intravenous injection of cells from these livers. The administration of warfarin suppresses the localization of colony-forming units in the regenerating liver by inhibiting the coagulation mechanism of the donor animals.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001854:Bone Marrow Cells; D002252:Carbon Tetrachloride Poisoning; D005260:Female; D066298:In Vitro Techniques; D008115:Liver Regeneration / Q000187:drug effects*; D051379:Mice; D013154:Spleen; D013347:Subcellular Fractions; D014812:Vitamin K / Q000494:pharmacology; D014859:Warfarin / Q000494:pharmacology*
D014812:Vitamin K; D014859:Warfarin