Factors influencing the rate of "aging" of a series of alkyl methylphosphonyl-acetylcholinesterases.
1. The progressive development of resistance to reactivation by an oxime (;aging') shown by a series of alkyl methylphosphonyl-acetylcholinesterases is slow when the alkyl group is a primary alcohol, whether or not the carbon chain is branched, but is much more rapid if the alkyl group is a secondary or cyclic alcohol. 2. Aging is accelerated by increase of temperature or decrease of pH. 3. Aging is inhibited by the quaternary amine N-methylpyridinium iodide. 4. The results are discussed in relation to the role played by aging in the therapy of poisoning by organophosphorus compounds.
D000110:Acetylcholinesterase; D000480:Alkynes / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002800:Cholinesterase Inhibitors / Q000506:poisoning; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007454:Iodides; D010091:Oximes; D011725:Pyridines; D013696:Temperature
D000480:Alkynes; D002800:Cholinesterase Inhibitors; D007454:Iodides; D010091:Oximes; D011725:Pyridines; D000110:Acetylcholinesterase