Metabolism of D-glucuronolactone in mammalian systems. Inhibitory properties of the products of D-glucuronolactone-dehydrogenase action.
1. d-Glucuronolactone was converted into d-glucaro-(1-->4)-lactone, a beta-glucuronidase inhibitor, probably via the intermediate d-glucaro-(1-->4)-(6-->3)-dilactone, by a dehydrogenase in human-liver extracts. 2. Similar experiments with mouse-liver extracts appeared to yield only d-glucaric acid or a non-inhibitory lactone. 3. A strong beta-glucuronidase inhibitor was present in mouse liver after the intraperitoneal administration of d-glucuronolactone. 4. d-Glucarodilactone decomposed spontaneously in aqueous solution to give 25% of d-glucaro-(1-->4)-lactone; the percentage conversion was unaffected by human-liver homogenates. but considerably increased by mouse-liver or pig-liver fractions.
D000818:Animals; D004798:Enzymes / Q000096:biosynthesis*; D006801:Humans; D007783:Lactones / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D010088:Oxidoreductases; D051381:Rats; D013552:Swine
D004798:Enzymes; D007783:Lactones; D010088:Oxidoreductases