Some observations on the behaviour of hypothalamic enzymes during the time of blastocyst implantation in the rabbit.
1. Hypothalami from pregnant and non-pregnant rabbits were homogenized in sucrose and separated into fractions by differential and density-gradient centrifugation. 2. The fractions were examined for enzymes capable of inactivating oxytocin. 3. Enzyme activity was detected in the supernatant and one particulate fraction of both pregnant and non-pregnant animals. 4. The specific activity of the enzymes increased during early pregnancy, and coincided with the time of blastocyst spacing and implantation in the uterus.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D010064:Embryo Implantation; D005260:Female; D007031:Hypothalamus / Q000201:enzymology*; D010121:Oxytocin; D011247:Pregnancy; D011270:Pregnancy, Animal; D011817:Rabbits
D010121:Oxytocin