A possible route to the production of free L-tyrosine O-sulphate by the rat.
1. l-Tyrosylglycine O[(35)S]-sulphate is metabolized by the rat to yield the O[(35)S]-sulphate esters of l-tyrosine, p-hydroxyphenylpyruvic acid and p-hydroxyphenylacetic acid. 2. The proportion of the administered peptide which is excreted as l-tyrosine O[(35)S]-sulphate is greater at a higher dose. 3. An enzyme capable of hydrolysing the peptide bond of l-tyrosylglycine O[(35)S]-sulphate to yield l-tyrosine O[(35)S]-sulphate has been detected in rat liver and kidney. 4. The activity of this enzyme is completely inhibited by a large excess of l-tyrosylglycine.
D000596:Amino Acids / Q000096:biosynthesis*; D000818:Animals; D002854:Chromatography, Paper; D004586:Electrophoresis; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D010455:Peptides / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013431:Sulfates; D013460:Sulfur Isotopes; D014443:Tyrosine
D000596:Amino Acids; D010455:Peptides; D013431:Sulfates; D013460:Sulfur Isotopes; D014443:Tyrosine