Control of haem synthesis by feedback inhibition on human-erythrocyte delta-aminolaevulate dehydratase.
The action of haem, haemoglobin and other haemoproteins on crude and purified delta-aminolaevulate dehydratase of human erythrocyte is described. The results show a feedback inhibition by haem of porphyrin synthesis at the level of erythrocyte delta-aminolaevulate dehydratase. Some kinetic characteristics of this inhibition are described.
D004912:Erythrocytes / Q000201:enzymology*; D005246:Feedback; D006418:Heme / Q000096:biosynthesis*; D006801:Humans; D006836:Hydro-Lyases / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D007982:Levulinic Acids; D011166:Porphyrins / Q000096:biosynthesis*
D007982:Levulinic Acids; D011166:Porphyrins; D006418:Heme; D006836:Hydro-Lyases