Biochemical studies of toxic agents. The metabolism of 1- and 2-bromopropane in rats.
1. (+)-n-Propylmercapturic acid sulphoxide, i.e. (+)-N-acetyl-S-n-propyl-l-cysteine S-oxide, was prepared as the dicyclohexylammonium salt, (-)-n-propyl-mercapturic acid sulphoxide was prepared as the free acid, and S-isopropyl-l-cysteine and isopropylmercapturic acid were also prepared. 2. The metabolism of 1- and 2-bromopropane was studied by radiochromatographic examination of the urine excreted by rats that had been fed with a diet containing (35)S-labelled yeast and then injected subcutaneously with these compounds. In addition to n-propyl-mercapturic acid and 2-hydroxypropylmercapturic acid, the excretion of which has already been reported, n-propylmercapturic acid sulphoxide was shown to be a metabolite of 1-bromopropane. Sulphur-containing metabolites of 2-bromopropane, if present in the urine at all, were there in very small amounts. 3. n-Propylmercapturic acid and isopropylmercapturic acid were isolated from the urine of rats that had been injected subcutaneously with S-n-propyl-l-cysteine and S-isopropyl-l-cysteine respectively.
D000818:Animals; D001965:Bromides / Q000378:metabolism*; D002854:Chromatography, Paper; D003545:Cysteine / Q000378:metabolism; D006838:Hydrocarbons / Q000378:metabolism*; D008297:Male; D015122:Mercaptopurine; D000644:Quaternary Ammonium Compounds; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013454:Sulfoxides; D013460:Sulfur Isotopes
D001965:Bromides; D006838:Hydrocarbons; D000644:Quaternary Ammonium Compounds; D013438:Sulfhydryl Compounds; D013454:Sulfoxides; D013460:Sulfur Isotopes; D015122:Mercaptopurine; D003545:Cysteine