Studies on natural gastric flora. I. Bacterial flora of fasting human subjects.
The presence and survival of ingested micro-organisms, both pathogenic and commensal, is of practical interest because the stomach is one of the principal portals of entry of bacteria in humans. A study of the environmental factors governing the survival of indigenous flora in the gastric lumen will assist in determining whether potentially pathogenic organisms will survive in the stomach and pass on. The authors set out to determine the significance of gastric mucin in such survival, with the ultimate objective of learning what factors provide optimal bactericidal conditions.Samples of gastric juice were aspirated from 149 fasting individuals; samples of saliva, nose and throat swabs were also obtained. Positive gastric cultures were found in 82%. The study of the effects of gastric pH demonstrated an increase in the number of samples showing growth above pH 2.0 and a concomitant increase in total bacterial growth. At a pH lower than 2.0, certain organisms are selected out. It appears that even minor changes in gastrointestinal physiology disrupt the normal clearing of the flora.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002648:Child; D005215:Fasting; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000382:microbiology*; D005752:Gastric Mucins / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009666:Nose / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D012463:Saliva / Q000382:microbiology
D005752:Gastric Mucins