Antagonism of purified asparaginase from guinea pig serum toward lymphoma.
The tumor inhibitory activity of highly purified asparaginase from guinea pig serum toward the Gardner lymphosarcoma in C3H mice was compared with that of the serum itself. The purified enzyme, homogeneous by ultracentrifugation and immunoelectrophoresis, had activity comparable to that of the serum. The serum was also effective in mice which were made immunologically incompetent by radiation with coba't-60.
D000581:Amidohydrolases / Q000627:therapeutic use*; D000818:Animals; D001216:Asparagine / Q000378:metabolism; D004586:Electrophoresis; D006168:Guinea Pigs; D007116:Immunization, Passive; D066298:In Vitro Techniques; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D014461:Ultracentrifugation
D001216:Asparagine; D000581:Amidohydrolases