Serotonin release from brain slices by electrical stimulation: regional differences and effect of LSD.
Slices of rat brain which had accumulated tritiated serotonin either in vivo or in vitro were superfused and electrically stimulated. There occurred a marked release of the exogenous amine and, to a lesser extent, its deaminated metabolites, which varied with the region of brain tested and was inhibited by lysergic acid diethylamide.
D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D004558:Electric Stimulation; D007031:Hypothalamus / Q000378:metabolism; D066298:In Vitro Techniques; D007503:Iron Isotopes; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013788:Thalamus / Q000378:metabolism; D014316:Tritium
D007503:Iron Isotopes; D014316:Tritium; D012701:Serotonin; D008238:Lysergic Acid Diethylamide