The effect of copper deficiency on the induction of tryptophan pyrrolase in chick liver by hydrocortisone.
The induction of tryptophan pyrrolase in chick liver by hydrocortisone was studied in copper- and magnesium-deficient chicks. Magnesium deficiency did not influence the induction of the enzyme, whereas copper deficiency significantly decreased it. These results suggest that tryptophan pyrrolase of chick liver, like that in Pseudomonas, is a copper-containing enzyme.
D000818:Animals; D003300:Copper / Q000378:metabolism*; D003677:Deficiency Diseases / Q000378:metabolism*; D004790:Enzyme Induction; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008275:Magnesium Deficiency / Q000378:metabolism; D010105:Oxygenases / Q000096:biosynthesis*; D011200:Poultry; D014366:Tryptophan Oxygenase / Q000096:biosynthesis
D003300:Copper; D010105:Oxygenases; D014366:Tryptophan Oxygenase; D006854:Hydrocortisone