Inhibition of B virus in cell culture by 5-iodo-2'-deoxyuridine.
The antimetabolite 5-iodo 2'-deoxyuridine (IDU) interferes with B virus replication in monolayers of cynomolgous monkey kidney, KB and HEp 2 cells. To determine the effect of this clinically active nucleoside in laboratory antiviral screening systems, several methods were compared. Most of the methods used were capable of detecting the activity of IDU at low levels.
D000998:Antiviral Agents / Q000494:pharmacology*; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D003857:Deoxyuridine / Q000494:pharmacology*; D006564:Herpesviridae / Q000187:drug effects*
D000998:Antiviral Agents; D003857:Deoxyuridine