Gluconeogenesis from amino acids in neonatal rat liver.
1. The utilization of amino acids for gluconeogenesis by rat liver develops in postnatal life, reaching maximum activity at the fifth day. 2. The activity of aspartate transaminase shows a similar trend in postnatal development and the increased activity appears to be due to the soluble enzyme. 3. The activity of alanine transaminase is low in foetal and postnatal rat liver and increases in activity at about the twentieth day. 4. Aspartate, glutamate and alanine make a major contribution to gluconeogenesis in the postnatal rat liver.
D000409:Alanine / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism; D005943:Gluconeogenesis; D005971:Glutamates / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D008112:Liver Glycogen / Q000096:biosynthesis; D010649:Phenylalanine / Q000378:metabolism; D011392:Proline / Q000378:metabolism; D051381:Rats; D012694:Serine / Q000378:metabolism; D013053:Spectrophotometry; D013912:Threonine / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D014633:Valine / Q000378:metabolism
D000596:Amino Acids; D005971:Glutamates; D008112:Liver Glycogen; D013912:Threonine; D001224:Aspartic Acid; D014443:Tyrosine; D012694:Serine; D010649:Phenylalanine; D006639:Histidine; D001120:Arginine; D011392:Proline; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007930:Leucine; D014633:Valine; D000409:Alanine; D005998:Glycine