Regulation of triglyceride synthesis in the parturient guinea-pig mammary gland.
1. The specific activity of the enzyme palmitoyl-CoA-l-glycerol 3-phosphate palmitoyltransferase (EC 2.3.1.15) in the mammary tissue of guinea pigs has been shown to increase 37-fold at parturition. 2. Increases also occur in tissue concentrations of glycerol 3-phosphate, CoA and free fatty acid, but not in that of acid-insoluble CoA. 3. The isolation and fatty acid composition of plasma triglyceride and of mammary-tissue free fatty acid, diglyceride and triglyceride are described. 4. The findings are discussed in relation to the regulation of milk fat synthesis.
D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D002849:Chromatography, Gas; D003065:Coenzyme A / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005989:Glycerides / Q000378:metabolism; D005994:Glycerophosphates / Q000378:metabolism; D006168:Guinea Pigs; D007774:Lactation; D008055:Lipids / Q000096:biosynthesis; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008892:Milk; D049590:Postpartum Period; D011247:Pregnancy; D011270:Pregnancy, Animal; D014280:Triglycerides / Q000096:biosynthesis* / Q000097:blood
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D005989:Glycerides; D005994:Glycerophosphates; D008055:Lipids; D014280:Triglycerides; D000217:Acyltransferases; D003065:Coenzyme A