Actinomycin D effect on amino acid absorption from rat jejunal loops.
The absorption of amino acids from jejunal loops was suppressed in anesthetized rats treated previously with 1.0 or 1.5 micrograms of actinomycin D per gram of body weight. The absorption of the acidic, neutral, and basic amino acids showed selective differences in response that were relative to the degree of inhibition and to the time interval required to demonstrate actinomycin sensitivity.
D000596:Amino Acids / Q000502:physiology*; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D003345:Corticosterone / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000502:physiology*; D012313:RNA / Q000096:biosynthesis; D051381:Rats
D000596:Amino Acids; D000963:Antimetabolites; D003609:Dactinomycin; D012313:RNA; D004247:DNA; D003345:Corticosterone