The interaction of aflatoxins with purines and purine nucleosides.
From measurements of thermal hyperchromicity and the behaviour of an aflatoxin-DNA mixture on a Sephadex column it was concluded that aflatoxin B(1) is capable of weak binding to single-stranded DNA. The interactions of the aflatoxins (B(1), G(1) and G(2)) with nucleosides result in difference spectra and suggest that the purine bases and the amino group play a role in the binding of all the aflatoxins to DNA.
D000225:Adenine; D000348:Aflatoxins; D000588:Amines; D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D004247:DNA; D006147:Guanine; D009705:Nucleosides; D011687:Purines; D013053:Spectrophotometry; D013696:Temperature; D013936:Thymidine; D013950:Thymus Gland
D000348:Aflatoxins; D000588:Amines; D009705:Nucleosides; D011687:Purines; D006147:Guanine; D004247:DNA; D000225:Adenine; D013936:Thymidine