Murine lymphoma: augmented growth in mice with pertussis vaccine-induced lymphocytosis.
Injection of Bordetella pertussis vaccine caused an excessive lymphocytosis, associated with an augmented growth of a lymphoma cell homotransplant in mice. A markedly impaired reactive cell proliferation was revealed in the spleens of the vaccine-pretreated mice after stimulation with phytohemagglutinin or Freund's complete adjuvant.
D000818:Animals; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology; D037102:Lectins / Q000494:pharmacology; D007938:Leukemia / Q000473:pathology*; D007942:Leukemia, Experimental; D008218:Lymphocytosis / Q000139:chemically induced*; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D009368:Neoplasm Transplantation; D010567:Pertussis Vaccine; D013154:Spleen / Q000473:pathology*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D037102:Lectins; D010567:Pertussis Vaccine; D005620:Freund's Adjuvant