Metabolism of pipecolic acid in a Pseudomonas species. V. Pipecolate oxidase and dehydrogenase.
Oxidation of pipecolate to Delta(1)-piperideine-6-carboxylate is catalyzed by pipecolate oxidase, an inducible, membrane-bound dehydrogenase associated with the electron transport components of Pseudomonas putida P2. From the oxidase, we obtained a smaller particle containing flavine adenine dinucleotide (FAD) and cytochrome b, but no longer able to catalyze electron transfer to oxygen or to cytochrome c. Certain properties of this l-pipecolate dehydrogenase, an FAD-flavoprotein, are reported.
D003580:Cytochromes / Q000494:pharmacology; D004573:Electrolytes / Q000494:pharmacology; D004579:Electron Transport; D005182:Flavin-Adenine Dinucleotide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D010088:Oxidoreductases / Q000032:analysis / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010875:Pipecolic Acids / Q000378:metabolism*; D010880:Piperidines / Q000096:biosynthesis; D011506:Proteins / Q000494:pharmacology; D011549:Pseudomonas / Q000201:enzymology* / Q000378:metabolism; D011796:Quinacrine / Q000494:pharmacology
D003580:Cytochromes; D004573:Electrolytes; D010875:Pipecolic Acids; D010880:Piperidines; D011506:Proteins; D005182:Flavin-Adenine Dinucleotide; D010088:Oxidoreductases; D011796:Quinacrine; D010100:Oxygen