Pemoline levels in brain: enhancement by dimethyl sulfoxide.
Pemoline-C(14) dissolved in dimethyl sulfoxide and injected intraperitoneally into rats was found in larger amounts in the brain than was a similar dose given in 0.3 percent tragacanth suspension. This appeared to be related to a partial breakdown of the blood-brain barrier in vivo by the dimethyl sulfoxide.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002247:Carbon Isotopes; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D010080:Oxazoles / Q000378:metabolism*; D010389:Pemoline / Q000032:analysis / Q000378:metabolism; D051381:Rats; D012116:Resins, Plant
D002247:Carbon Isotopes; D010080:Oxazoles; D012116:Resins, Plant; D010389:Pemoline; D004121:Dimethyl Sulfoxide