The effects of diethylstilboestrol and castration on the nucleic acid and protein metabolism of rat prostate gland.
1. Implantation of diethylstilboestrol pellets into adult male rats brings about similar biochemical changes in the nucleic acid and protein metabolism to castration. 2. The avidity of the prostate for labelled diethylstilboestrol was greater than that of the other organs examined. 3. Uptake of labelled diethylstilboestrol and testosterone into the nuclei of the rat prostate is greater in castrated rats than in controls. 4. Diethylstilboestrol appeared to be associated with the protein and not with the DNA fraction of the nucleus.
D000818:Animals; D002247:Carbon Isotopes; D002369:Castration; D002499:Centrifugation, Density Gradient; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009696:Nucleic Acids / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism; D011467:Prostate / Q000187:drug effects*; D012316:RNA Nucleotidyltransferases / Q000378:metabolism; D051381:Rats; D013739:Testosterone / Q000378:metabolism*; D014316:Tritium
D002247:Carbon Isotopes; D009696:Nucleic Acids; D014316:Tritium; D013739:Testosterone; D010649:Phenylalanine; D004054:Diethylstilbestrol; D012316:RNA Nucleotidyltransferases