Antigenic competition: cellular or humoral.
The injection of one antigen into mice inhibited the response to a second when 1 to 10 days separated the two injections. When the same type of inhibition was attempted in gamma-irradiated mice reconstituted with normal spleen cells, the inhibition was greater in mice receiving 50 million spleen cells than in those receiving 10 million. The results are interpreted as favoring a humoral mechanism of inhibition.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000037:antagonists & inhibitors*; D004912:Erythrocytes; D005246:Feedback; D005260:Female; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D011830:Radiation Effects; D013154:Spleen / Q000166:cytology*
D000941:Antigens; D006460:Hemolysin Proteins