Cation movements in the high sodium erythrocyte of the cat.
The uptake of (42)K and (24)Na by cat erythrocytes was investigated. Under steady-state conditions, the nontransient component of (42)K influx was found to be 0.18 +/- 0.01 meq/liter RBC/hr and insensitive to ouabain (100 microM); the corresponding value for (24)Na was 17 +/- meq/liter RBC/hr. A study was made of the effects of anions upon cation movements in these and other mammalian red cells. Iodide was found to inhibit markedly (>50%) Na inward movements in cat and dog but not in the other erythrocytes. An increase (15-30%) in K uptake in the presence of iodide was noted in all the mammalian cells studied.
D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology*; D002415:Cats; D002463:Cell Membrane Permeability / Q000187:drug effects; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism*; D007454:Iodides / Q000494:pharmacology; D008962:Models, Theoretical; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D011194:Potassium Isotopes; D011817:Rabbits; D012756:Sheep; D012964:Sodium / Q000378:metabolism*; D012975:Sodium Isotopes
D007454:Iodides; D011194:Potassium Isotopes; D012975:Sodium Isotopes; D010042:Ouabain; D012964:Sodium; D011188:Potassium