Irreversible enzyme inhibitors. 108. 6-(p-chloroacetylanilinomethyl)-5-(p-chlorophenyl)-2,4-diaminopyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase.
D000818:Animals; D001665:Binding Sites; D010856:Columbidae; D005493:Folic Acid Antagonists; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000201:enzymology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats
D005493:Folic Acid Antagonists; D011743:Pyrimidines