Imine-bonding in membrane transport of monosaccharides: invalidity of kinetic evidence.
The proposition that carrier mediation of sugar transport may involve formation of imine complexes with specific cell membrane proteins has recently been advanced. However, the primary data presented accord more quantitatively with the presumption of a nonspecific reaction and furnish no evidence for the existence of the high-affinity glucose-binding sites which are essential to the proposed interpretation.
D001665:Binding Sites; D001692:Biological Transport; D001798:Blood Proteins / Q000096:biosynthesis*; D002247:Carbon Isotopes; D002462:Cell Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007097:Imines / Q000378:metabolism*; D007700:Kinetics
D001798:Blood Proteins; D002247:Carbon Isotopes; D007097:Imines; D005947:Glucose