Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells.
Cultured cells derived from male patients with Burkitt's lymphoma and harboring herpes-type virus particles were lethally irradiated. These irradiated cells induced normal peripheral leukocytes of female infants to grow within 2 to 4 weeks after mixed cultivation. Cells of a line free of this agent failed to stimulate growth. If either type of cell was cultured separately, it did not survive under the experimental conditions. Herpes-type viral antigen and C-group chromosomal marker previously described in cultured Burkitt cells were found in all of the female cell cultures that were obtained.
D002051:Burkitt Lymphoma; D002875:Chromosomes; D046508:Culture Techniques; D005260:Female; D006564:Herpesviridae / Q000276:immunology; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007962:Leukocytes / Q000166:cytology* / Q000528:radiation effects; D008223:Lymphoma; D011830:Radiation Effects