Myxovirus-like structures in a case of human chronic polymyositis.
Intranuclear and intracytoplasmic aggregates of filaments with tubular structures and transverse striations occurred in muscle tissues biopsied from a patient with chronic polymyositis. The filamentous tubules bear a close resemblance to the incomplete form of myxovirus in which the envelope is missing. Three biopsies from the same patient, taken during a period of 1(1/2) years, all revealed these structures. This finding provides presumptive evidence that a chronic persistent viral infection may be involved in the pathogenesis of chronic polymyositis.
D000368:Aged; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009220:Myositis / Q000382:microbiology*; D009975:Orthomyxoviridae / Q000302:isolation & purification*