Enzyme-catalysed conjugations of glutathione with unsaturated compounds.
1. Rat-liver supernatant catalyses the reaction of diethyl maleate with glutathione. 2. Evidence is presented that the enzyme involved is different from the known glutathione-conjugating enzymes, glutathione S-alkyltransferase, S-aryltransferase and S-epoxidetransferase. 3. Rat-liver supernatant catalyses the reaction of a number of other alphabeta-unsaturated compounds, including aldehydes, ketones, lactones, nitriles and nitro compounds, with glutathione: separate enzymes may be responsible for these reactions.
D000143:Acids / Q000378:metabolism; D000179:Acrylates / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism; D002934:Cinnamates / Q000378:metabolism; D003374:Coumarins / Q000378:metabolism; D003486:Cyanides; D005030:Ethylenes / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D007093:Imidazoles / Q000378:metabolism; D066298:In Vitro Techniques; D007659:Ketones / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008298:Maleates / Q000378:metabolism; D051381:Rats; D012500:Santonin / Q000378:metabolism; D014166:Transferases / Q000378:metabolism*
D000143:Acids; D000179:Acrylates; D000447:Aldehydes; D000903:Antibiotics, Antineoplastic; D002934:Cinnamates; D003374:Coumarins; D003486:Cyanides; D005030:Ethylenes; D007093:Imidazoles; D007659:Ketones; D008298:Maleates; D012500:Santonin; D014166:Transferases; D005978:Glutathione