The metabolism of phenethyl bromide, styrene and styrene oxide in the rabbit and rat.
1. The chief sulphur-containing metabolite of styrene and sytrene oxide in the rabbit and rat is chromatographically identical with N-acetyl-S-(beta-hydroxyphenethyl)-l-cysteine and this compound is also formed, together with N-acetyl-S-phenethyl-l-cysteine, as a metabolite of phenethyl bromide. 2. The amounts of the phenethylmercapturic acid and its hydroxy derivative excreted in the urine of animals dosed with phenethyl bromide, styrene, styrene oxide, phenyl glycol, S-phenylethylcysteine and phenethylmercapturic acid have been determined. 3. Liver slices convert phenethylcysteine and phenethylmercapturic acid into N-acetyl-S-(beta-hydroxyphenethyl)-l-cysteine. 4. Methods for the determination by gas-liquid chromatography of mandelic acid and hippuric acid, which are metabolites of some of the compounds studied, are described.
D000818:Animals; D001965:Bromides / Q000378:metabolism; D002247:Carbon Isotopes; D002849:Chromatography, Gas; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D003545:Cysteine / Q000652:urine; D005260:Female; D006626:Hippurates / Q000032:analysis; D006846:Hydrocarbons, Halogenated / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008333:Mandelic Acids / Q000032:analysis; D010087:Oxides / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013343:Styrenes / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000652:urine; D013455:Sulfur / Q000378:metabolism*; D013460:Sulfur Isotopes
D001965:Bromides; D002247:Carbon Isotopes; D006626:Hippurates; D006846:Hydrocarbons, Halogenated; D008333:Mandelic Acids; D010087:Oxides; D013343:Styrenes; D013438:Sulfhydryl Compounds; D013460:Sulfur Isotopes; D013455:Sulfur; D003545:Cysteine