The relation between secretion of urate and p-aminohippurate in the rabbit kidney.
1. The renal excretion of urate in the rabbit was examined during infusion of other anions which are secreted by the kidney. A reduction of urate excretion occurred after administration of p-aminohippurate (PAH) and Diodrast which was proportional to the secretory rate of these compounds. On the other hand, urate was a less efficient inhibitor of PAH secretion.2. Stop-flow experiments showed that tubular secretion of urate at maximal values for secretion of PAH and Diodrast was almost completely suppressed.3. 2,4-Dinitrophenol, fumarate, succinate, salicylate, and probenecid depressed the excretion of urate and PAH, but the tubular secretion of urate was apparently more depressed than that of PAH by these inhibitors.4. It is concluded that a common transport system for urate and PAH is involved in the tubular secretion of urate and PAH in the rabbit. However, the affinity of urate for the transport system appears to be smaller than that of PAH.
D000143:Acids / Q000494:pharmacology; D000618:Aminohippuric Acids / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport; D004140:Dinitrophenols / Q000494:pharmacology; D007444:Inulin / Q000652:urine; D007468:Iodopyracet / Q000494:pharmacology; D007668:Kidney / Q000502:physiology*; D008297:Male; D008657:Metabolic Clearance Rate; D011817:Rabbits; D014527:Uric Acid / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*
D000143:Acids; D000618:Aminohippuric Acids; D004140:Dinitrophenols; D014527:Uric Acid; D007444:Inulin; D007468:Iodopyracet