Chromosome abnormality in rat leukemia induced by 7,12-dimethylbenz[a]anthracene.
A high percentage of consistent chromosome abnormality, trisomy of the longest telocentric chromosome, was found in leukemias induced in rats of the Long-Evans strain by pulse doses of 7,12-dimethylbenz[a]anthracene. Cells with this abnormality were large, immature, and mononuclear and tended toward erythroblastic maturation.
D000818:Animals; D001551:Benz(a)Anthracenes; D001854:Bone Marrow Cells; D002875:Chromosomes / Q000187:drug effects*; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced*; D007945:Leukemia, Lymphoid / Q000139:chemically induced; D008297:Male; D051381:Rats; D013154:Spleen / Q000166:cytology; D014314:Trisomy / Q000138:chemical synthesis*
D001551:Benz(a)Anthracenes