title: Suppression of food and water intake after intracerebroventricular infusion of morphine and naloxone in rabbits.
abstract: The effect of intracerebroventricular infusion of morphine and naloxone on food and water intake was investigated in rabbits. Morphine hydrochloride at a dose of 120, 10 and 5 micrograms produced statistically significant suppression of 24-h food and water intake. The same effect ensued after infusion of naloxone at dose of 120 and 10 micrograms. Postmorphine aphagia was accompanied by a rise in blood free fatty acids and normal glucose levels. No changes were seen after naloxone.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002552:Cerebral Ventricles / Q000187:drug effects; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005508:Food Deprivation; D007328:Insulin / Q000097:blood; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D009270:Naloxone; D009020:Morphine