[Action of low-molecular compounds of a polyphenol-quinoid nature from an irradiated organism on cytochrome C].
It was shown that gamma-radiation-induced oxidation of phenol compounds in the animal liver, which leads to o-dioxyphenols and quinones accretion, is one of the reasons for excluding cytochrome c from the respiratory chain of mitochondria. Radiochemical oxidation of tyrosil groups at the protein site of cytochrome c and, as a result, the restriction in the rate of reduction of the latter were noted. On the basis of the data obtained the authors discuss the mechanism of weakening the coupling of oxidation to phosphorylation upon irradiation and the molecular mechanism of the so-called cytochrome effect.
D000818:Animals; D003574:Cytochrome c Group / Q000378:metabolism* / Q000528:radiation effects; D005419:Flavonoids; D005720:Gamma Rays; D066298:In Vitro Techniques; D008099:Liver / Q000528:radiation effects; D008297:Male; D008970:Molecular Weight; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D010636:Phenols / Q000494:pharmacology* / Q000528:radiation effects; D011108:Polymers / Q000494:pharmacology* / Q000528:radiation effects; D059808:Polyphenols; D011809:Quinones / Q000494:pharmacology* / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003574:Cytochrome c Group; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D011809:Quinones
O deĭstvii nizkomolekuliarnykh soedineniĭ polifenol'no-khinoidnoĭ prirody iz obluchennogo organizma na tsitokhrom C.