title: Central effects following repeated treatment with antidepressant drugs.
abstract: The review sums up the results of experiments in which there were studied central effects following repeated administration of various antidepressant drugs (AD) in rats and mice. A number of typical and atypical AD, except for selective inhibitors of 5-hydroxytryptamine (5-HT) uptake, potentiate the clonidine aggressiveness in mice (medicated by alpha 1-adrenoceptors). These results indicate that the repeated AD administration enhances responsiveness of central postsynaptic alpha 1-adrenoceptors. This assumption is in accordance with electrophysiological literature data. A few AD (including citalopram, a selective inhibitor of the 5-HT uptake), administered repeatedly, potentiate the locomotor hyperactivity induced by D-amphetamine or apomorphine, without affecting the stereotypy evoked by both dopaminomimetics. It may be supposed that AD enhance the responsiveness of a dopamine (DA) system, probably the mesolimbic one (but not the striatal one). A repeated administration of various AD also counteracts the locomotor hypoactivity induced by salbutamol (mediated by a beta-adrenoceptor). The importance of the effects stated above (alpha 1 up-regulation, DA up-regulation, beta down-regulation) for the mechanism of antidepressant action has been discussed.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D003913:Dextroamphetamine / Q000494:pharmacology; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects; D006614:Hindlimb / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D013134:Spiperone / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D011942:Receptors, Adrenergic, alpha; D011954:Receptors, Dopamine; D013134:Spiperone; D012110:Reserpine; D000242:Cyclic AMP; D007545:Isoproterenol; D003000:Clonidine; D001058:Apomorphine; D003913:Dextroamphetamine; D009638:Norepinephrine