[Endogenous morphines in chronic progressive diseases of the central nervous system].
Using radioimmunoassay the authors studied concentrations of beta-endorphine and metenkephalin in the cerebrospinal fluid (CSF) of 65 patients with various diseases of the central nervous system (CNS)--hereditary extrapyramidal disorders, disseminated sclerosis (DS), lateral amyotrophic sclerosis (LAS), spinal tumours, senile dementia, some CNS impairments of inflammatory nature. Patients with spinal tumours showed a 4-14-fold elevation in metenkephalin levels along with a comparatively high content of beta-endorphine. In senile dementia, the concentration of both peptides was lowered. In hereditary extrapyramidal diseases, the levels of beta-endorphine were also low, while there was no concomitant decrease in the metenkephalin concentration.
D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid*; D002908:Chronic Disease; D003704:Dementia / Q000134:cerebrospinal fluid; D004723:Endorphins / Q000134:cerebrospinal fluid*; D004744:Enkephalin, Methionine / Q000134:cerebrospinal fluid; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D011863:Radioimmunoassay; D013120:Spinal Cord Neoplasms / Q000134:cerebrospinal fluid; D001615:beta-Endorphin
D004723:Endorphins; D004744:Enkephalin, Methionine; D001615:beta-Endorphin
Endogennye morfiny pri khronicheskikh progressiruiushchikh zabolevaniiakh tsentral'noĭ nervnoĭ sistemy.