The partitioning of delta 1-tetrahydrocannabinol into erythrocyte membranes in vivo and its effect on membrane fluidity.
delta 1-Tetrahydrocannabinol (delta 1-THC) has been quantified directly in erythrocyte membranes from drug-treated mice using gas chromatography/mass spectrometry. Concentrations of approximately 6 ng delta 1-THC/mg membrane protein (10(-5) M) were found when effects of the drug on behavior were prevalent. At these concentrations the drug produced a decrease in membrane order as measured by ESR.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D013759:Dronabinol / Q000097:blood* / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000502:physiology*; D007700:Kinetics; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008565:Membrane Proteins / Q000097:blood; D051379:Mice
D008565:Membrane Proteins; D013759:Dronabinol