Mapping brain neuroleptic receptors in the live baboon.
An experimental strategy for external detection of specific neuroleptic receptors in living brain using positron emission transaxial tomography (PETT) and [11C]spiroperidol was applied to the mapping of brain neuroleptic receptors in the live baboon. A double injection of [11C]spiroperidol with an intervening time interval for carbon-11 decay and an intervening dose of (+)-butaclamol to block specific neuroleptic receptors produced two sets of PETT scans which were subtracted to produce a three-dimensional map of relative regional binding of neuroleptic receptors in the baboon brain. Sixty-five percent of the total radioactivity in the striatum was bound to neuroleptic receptors at 65 min after injection.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002069:Butaclamol / Q000494:pharmacology; D005260:Female; D010215:Papio / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism; D014055:Tomography, Emission-Computed
D011954:Receptors, Dopamine; C028051:neuroleptic receptor; D013134:Spiperone; D002069:Butaclamol