title: [Protein-synthesizing apparatus of the rat liver and placenta during damage of the biomembrane by tetrachloromethane and the administration of methylxanthines].
abstract: Treatment of rats with tetrachloromethane was accompanied by a decrease in total ribosomal material, an increase in free, unbound with membranes, polyribosomal fraction and marked decrease in 14C-leucine and 3H-orotate incorporation into proteins and RNA of liver and placenta cells. Administration of methylxanthines--euphylline and trental protected the protein-synthesizing apparatus of hepatocytes and placenta from the damaging effects of tetrachloromethane. The role of microsomal monooxygenase system in tetrachloromethane activation and in impairment of cAMP-dependent regulation of translation process under conditions of xenobiotic-induced cell injury are discussed.
mesh_terms: D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009963:Orotic Acid / Q000378:metabolism; D010431:Pentoxifylline / Q000494:pharmacology; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D014176:Protein Biosynthesis / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014970:Xanthines / Q000494:pharmacology*
chemical_list: D014970:Xanthines; D000628:Aminophylline; C008514:methylxanthine; D009963:Orotic Acid; D012313:RNA; D002251:Carbon Tetrachloride; D000242:Cyclic AMP; D007930:Leucine; D010431:Pentoxifylline
vernacular_title: Beloksinteziruiushchiĭ apparat pecheni i platsenty krys pri povrezhdenii biomembran tetrakhlormetanom i vvedenii metilksantinov.