Polybrominated biphenyls are nongenotoxic and produce an epigenetic membrane effect in cultured liver cells.
Polybrominated biphenyls (PBB) were studied for their genotoxic and epigenetic effects in cultured liver cells. PBB did not elicit DNA repair synthesis in rat, mouse, or hamster hepatocytes in primary cultures and did not cause mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in a line of rat liver epithelial cells or in human fibroblasts cocultivated with rat hepatocytes as an activating system. In contrast, PBB inhibited intercellular molecular exchange between rat hepatocytes and liver epithelial cells indicating an epigenetic membrane effect. These data are consistent with the interpretation that PBB act as neoplasm promoters in the production of rodent liver neoplasms.
D000818:Animals; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006151:Guanosine / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009152:Mutagenicity Tests; D011075:Polybrominated Biphenyls / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity; D013872:Thionucleosides / Q000378:metabolism
D011075:Polybrominated Biphenyls; D013872:Thionucleosides; D006151:Guanosine; C005783:6-thioguanosine