title: Dissociation of the functioning of a human parotid gland following trauma of the tympanic nerve (a pseudocolchicine phenomenon).
abstract: In a group of patients with break-up of the tympanic nerve, restitution of unconditioned reflexes in a denervated parotid gland was accompanied with both an increased sensitivity to cholinergic agonists and a sharply perverted paradoxal secretory response to antagonists (atropine, scopolamine, metacine, chlorosile). The above phenomenon is similar to the syndrome resulting from the effect of colchicine on the nervous-muscle connection when, mediatory transmission remaining intact, a post-denervational increased sensitivity to mediators of cholinergic excitation is observed.
mesh_terms: D000328:Adult; D001285:Atropine / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000293:injuries* / Q000502:physiology; D010306:Parotid Gland / Q000294:innervation* / Q000378:metabolism; D012018:Reflex; D012472:Salivation / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D001285:Atropine; D003078:Colchicine