The prostaglandin inhibitor effect of antiinflammatory drugs in the therapy of male infertility.
The effects of various doses of indomethacin and ketoprofen as compared with placebo were examined in 100 oligospermic patients who participated in this study. It was found that the treatment increased sperm count, sperm motility, and fertilizing capacity. The radioimmunoassay examination showed an increase in plasma follicle-stimulating hormone and luteinizing hormone but a decrease in testosterone. The results show that the influence of indomethacin was better in the dose of 75 mg daily. The mechanism of those changes is not clear. Treatment should be at least 60 days.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000242:Cyclic AMP / Q000378:metabolism; D015237:Dinoprost; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007660:Ketoprofen / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000097:blood / Q000188:drug therapy*; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D012661:Semen / Q000187:drug effects / Q000378:metabolism; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D007660:Ketoprofen; D015237:Dinoprost; D000242:Cyclic AMP; D015232:Dinoprostone; D007213:Indomethacin