Delayed-type hypersensitivity to myelin basic proteins in mice susceptible to allergic encephalomyelitis.
The delayed-type hypersensitivity (DTH) response in mice immunized with autologous spinal cord homogenate or purified myelin basic protein (MBP) was measured by the 125I-UdR uptake ear assay. Mice were tested for DTH responses with MBP preparations from different species and with synthetic peptides. The 114-122 and 68-84 peptide regions appear to be major determinants for inducing and eliciting DTH in the mice which are susceptible to allergic encephalomyelitis.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D004198:Disease Susceptibility; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D006824:Hybridization, Genetic; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D004676:Myelin Basic Protein / Q000276:immunology*
D000939:Epitopes; D004676:Myelin Basic Protein