title: Ca2+ dependence of the release of noradrenaline during nerve degeneration in the parotid gland.
abstract: Amylase secretion "in vitro" was used as an indication of the degeneration activity of sympathetically denervated parotid glands. Seventeen and a half hours after sympathetic denervation, slices of parotid gland released amylase into the incubation medium at a rate higher than that observed for non-denervated glands. The time course of amylase release from denervated glands followed a bell-shaped pattern similar to that observed in other denervated structures. Lowering extracellular Ca2+ to 0.25 mmol/l diminished significantly the release of amylase. Low Ca2+ however, did not decrease the amylase release in response to added noradrenaline. These results indicate that Ca2+ is required for the release of noradrenaline from degenerating nerve endings.
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000502:physiology*; D005260:Female; D009410:Nerve Degeneration; D009638:Norepinephrine / Q000378:metabolism*; D010306:Parotid Gland / Q000201:enzymology / Q000294:innervation / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000681:Amylases; D002118:Calcium; D009638:Norepinephrine