[Activation of cellular genes as affected by Rauscher leukemia virus].
The methods of hybridization in solution and blot hybridization have shown that the BALB/c mice spleen cells contain "silent" genes which can amplificate and change their structure following the infection by the Rauscher leukemia virus (RLV). The product of these gene activation is nuclear 35S RNA detectable by the comparative electrophoretic analysis of heterogeneous nuclear RNA of leukemic and normal cells. The expression of complete copies of 35S RNA was observed in nuclei of RLV-infected cells, while in cytoplasm this RNA is represented by incomplete copies. The expression of the sequences homologous to this 35 S RNA in normal mice spleen cells was not detected.
D000818:Animals; D004247:DNA / Q000235:genetics; D005784:Gene Amplification; D005786:Gene Expression Regulation; D007942:Leukemia, Experimental / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D011925:Rauscher Virus / Q000235:genetics* / Q000472:pathogenicity; D013154:Spleen / Q000648:ultrastructure; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D012334:RNA, Neoplasm; D012367:RNA, Viral; D012313:RNA; D004247:DNA
Aktivatsiia kletochnykh genov pod vliianiem virusa leĭkoza Raushera.