title: [Nucleic acid metabolism in rat hematopoietic tissues during and after prolonged administration of different doses of tritium oxide].
abstract: During the long-term administration to rats of tritium oxide in doses of 0.37, 0.925 and 1.85 MBq/g body mass the content of karyocytes and nucleic acids in the bone marrow and spleen was decreased, the rate of their biosynthesis changed, the DNA structure impaired, the content of salt-soluble polydeoxynucleotides increased, and DNAases activated. The observed changes were function of dose. After the end of the administration of the isotope the animals which had received a lesser tritium dose exhibited a more rapid and complete recovery.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis*; D004277:DNA, Single-Stranded / Q000096:biosynthesis; D003851:Deoxyribonucleases / Q000378:metabolism; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism* / Q000528:radiation effects; D013997:Time Factors; D014316:Tritium / Q000008:administration & dosage*; D014867:Water / Q000008:administration & dosage*
chemical_list: D004277:DNA, Single-Stranded; D014867:Water; D014316:Tritium; C033961:tritium oxide; D012313:RNA; D004247:DNA; D003851:Deoxyribonucleases
vernacular_title: Metabolizm nukleinovykh kislot v krovetvornykh tkaniakh krys v protsesse i posle okonchaniia dlitel'nogo vvedeniia okisi tritiia v raznykh dozakh.