[Radioprotective properties of the polysaccharide dextran sulfate].
It has been shown that a single intraperitoneal injection of dextran sulfate (molecular weight 500 000, 60 mg/kg) to (CBA X C57BL)F1 mice 1-3 days before irradiation in lethal doses, with the irradiation dosage amounting to 8.10(-3), 3.10(-3) and 8.10(-4) Gy/c, increases the animals' survival rate. The effect of dextran sulfate on the degree of postradiation changes in the blood leukocyte count and in the bone marrow karyocyte count depends on the interval between dextran sulfate injection and irradiation.
D000818:Animals; D016264:Dextran Sulfate; D003911:Dextrans; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control; D011837:Radiation-Protective Agents; D013997:Time Factors
D003911:Dextrans; D011837:Radiation-Protective Agents; D016264:Dextran Sulfate
Radiozashchitnye svoĭstva polisakharida dekstransul'fata.