Suppression of food and water intake after intracerebroventricular infusion of morphine and naloxone in rabbits.
The effect of intracerebroventricular infusion of morphine and naloxone on food and water intake was investigated in rabbits. Morphine hydrochloride at a dose of 120, 10 and 5 micrograms produced statistically significant suppression of 24-h food and water intake. The same effect ensued after infusion of naloxone at dose of 120 and 10 micrograms. Postmorphine aphagia was accompanied by a rise in blood free fatty acids and normal glucose levels. No changes were seen after naloxone.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002552:Cerebral Ventricles / Q000187:drug effects; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005508:Food Deprivation; D007328:Insulin / Q000097:blood; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D009270:Naloxone; D009020:Morphine