Patency and neo-intima development in 10 cm-long microvascular polyurethane prostheses implanted into the rat aorta.
Microvascular fibrous polyurethane prostheses (inner diameter 1.5 mm, length 10 cm) were implanted in the abdominal aorta of rats. The prostheses were fixed in a loop. All rats (n = 37) were reoperated 6 weeks after implantation to verify the patency of the prostheses. Eight prostheses were obliterated from various causes. The remaining 29 prostheses were found to be patent 3 months after implantation, which gives a patency rate of 79%. Six weeks and 3 months after implantation 7 and 4 rats, respectively, with patent prostheses were sacrificed. The remaining 18 rats of this study are still alive, more than 4 months after implantation, and will be included in long-term observation studies. The prostheses were examined using both light and scanning electron microscopy. The patent prostheses exhibited macroscopically a clear and transparent inner surface. No obliterative processes could be found either macroscopically or microscopically. Neo-intima ingrowth had advanced +/- 10 mm into the prostheses over the anastomotic line from both ends 3 months after implantation, and was continued by a single endothelium layer for several centimeters. An acellular, stable fibrin film was found inbetween the cellular lining. The neo-intima was anchored at the prosthesis by cellular protrusions extending between the polyurethane fibers. Though 10 cm long prostheses were implanted under unfavorable hemodynamic conditions, a patency rate of 79% was achieved, both 6 weeks and 3 months after implantation. This patency rate could have been higher if evident technical failures had been avoided.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D001807:Blood Vessel Prosthesis; D004727:Endothelium / Q000473:pathology; D005337:Fibrin / Q000378:metabolism; D006083:Graft Occlusion, Vascular / Q000473:pathology / Q000503:physiopathology*; D006439:Hemodynamics; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes; D051381:Rats; D011919:Rats, Inbred Strains; D012212:Rheology
D011140:Polyurethanes; D005337:Fibrin