[Interaction of the circadian rhythms of the functional activity of the hypophyseal-adrenal system and of the mitotic activity in the esophageal epithelium of rats with experimental hypo- and hypercorticism].
In experimental hypercorticism the average daily concentration of glucocorticoids in blood plasma is 4 times higher than in control one, the amplitude of the circadian rhythm increases almost 3 times, the time of maximum concentration does not change. The adrenocorticotrophic hormone (ACTH) average circadian concentration decreases twofold. The adrenalectomy results in abrupt smoothing down of the circadian rhythm of glucocorticoids concentration and in increasing (in 2,4 times) of the average circadian concentration of ACTH. The pattern of circadian rhythm remains, however the acrophase of hormone secretion is shifted. The circadian rhythm of cells devision in esophagus epithelium changes. The maximum of mitotic index is absent in adrenalectomized rats and the amplitude of its circadian variations decreases. In experimental hypercorticism the biphase rhythm of mitoses in induced.
D000309:Adrenal Insufficiency / Q000503:physiopathology*; D000315:Adrenalectomy; D000308:Adrenocortical Hyperfunction / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D002940:Circadian Rhythm; D004848:Epithelium / Q000473:pathology; D004947:Esophagus / Q000473:pathology*; D005938:Glucocorticoids / Q000097:blood; D008297:Male; D008938:Mitosis; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D051381:Rats
D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone
Vzaimosviaz' sutochnykh ritmov funktsional'noĭ aktivnosti gipofizarno-nadpochechnikovoĭ sistemy i mitoticheskoĭ aktivnosti v épitelii pishchevoda u krys pri éksperimental'nom gipo- i giperkortitsizme.