title: Testicular gonadotropin receptors, testicular testosterone, dihydrotestosterone and androstenedione in the developing bull.
abstract: The testis homogenate from Red bull (3-17 months of age) show specific binding of hLH and hFSH with Kd of 1.3 +/- 0.1 X 10(-10)M and 1.5 +/- 0.1 X 10(-9)M, respectively. Prepubertal bulls (3-5 3/4 months) exhibit the highest binding capacity of both LH and FSH, revealing the fact that LH and FSH receptors are present in high concentrations prior to the first rise in plasma T. The testicular T concentration was significantly higher in the four prepubertal bulls than in the four older animals in spite of the fact that circulating T is lower before puberty. Thus, local androgen effects within the testis may occur before peripheral androgenization. The prepubertal bull Leydig cell also displayed steroidogenic capacity. The ratio of biologically active (testosterone, dihydrotestosterone) to inactive androgens (androstenedione) increased as the animals approached puberty. Such qualitative changes in steroid production may be one of the factors responsible for peripheral androgenization.
mesh_terms: D000728:Androgens / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D002417:Cattle / Q000502:physiology*; D013196:Dihydrotestosterone / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011962:Receptors, FSH; D011974:Receptors, LH; D012741:Sexual Maturation; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism
chemical_list: D000728:Androgens; D011956:Receptors, Cell Surface; D011962:Receptors, FSH; D011974:Receptors, LH; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone