HNK-1-defined antigen detected in paraffin-embedded neuroectoderm tumors and those derived from cells of the amine precursor uptake and decarboxylation system.
The reactivity of the HNK-1 monoclonal antibody that, besides a subset of hematopoietic cells with natural killer activity, also detects neuroectodermal cells, was screened on 153 human tumors. Immunoperoxidase staining of paraffin sections revealed that HNK-1 detects neuroectoderm-derived cancers and tumors with endocrine activity. Because the antigen detected by HNK-1 is well conserved in paraffin sections, this antibody is of potential diagnostic value in routine histopathology and might help to elucidate the histogenesis of some poorly understood tumors.
D000328:Adult; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm / Q000032:analysis*; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D005333:Fetus; D006652:Histological Techniques; D006801:Humans; D007124:Immunoenzyme Techniques; D009369:Neoplasms / Q000473:pathology*; D009380:Neoplasms, Nerve Tissue / Q000276:immunology / Q000473:pathology*; D010232:Paraffin; D011247:Pregnancy; D013724:Teratoma / Q000473:pathology; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D010232:Paraffin