Experimental infection of cynomolgus monkeys with a human retrovirus, adult T-cell leukemia virus.
The experimental infection of six cynomolgus monkeys with adult T-cell leukemia virus (ATLV) was attempted. Three animals were inoculated with living MT-2 cells and three with cell-free ATLV. All animals developed an antibody response to virus-specific glycopolypeptides and viral core polypeptides. ATLV-specific antigens appeared in peripheral lymphocytes from all six animals. Virus expression persisted in all animals. Up to 40 weeks after inoculation no animal developed any symptom of leukemia.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000302:isolation & purification; D017977:Deltaretrovirus / Q000276:immunology; D005260:Female; D006801:Humans; D008252:Macaca fascicularis; D008297:Male; D012192:Retroviridae Infections / Q000209:etiology*; D013997:Time Factors; D014412:Tumor Virus Infections / Q000209:etiology*
D000914:Antibodies, Viral; D000956:Antigens, Viral