title: Splenic granulopoietic morphology in laboratory rats after experimental induction of marrow hypoplasia.
abstract: Within the granulopoietic recovery phase the proportion of neutrophils and their precursors in the spleen was elevated from 1.7 +/- 0.3% (controls) to 14.7 +/- 2.2% (on day 14 after cyclophosphamide). Splenic granulopoiesis persisted for a time after the appearance of marrow recovery. These data suggest that the rat adult spleen can become a markedly granulopoietic organ during the regeneration of granulopoiesis which follows experimentally induced myelosuppression.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity*; D004804:Eosinophils / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects; D013154:Spleen / Q000187:drug effects*
chemical_list: D003520:Cyclophosphamide