Enalapril treatment in a patient with impaired renal function and intolerance to captopril.
In a 36-year-old woman with malignant hypertension and moderate renal insufficiency from nephrosclerosis normotension was not achieved by the combination of a beta-blocker, a vasodilator, and a loop-diuretic. The angiotensin-converting enzyme (ACE) inhibitor captopril was then added to the therapy. The blood pressure control was good. However, due to adverse reactions, captopril had to be withdrawn. Later on, the patient was successfully treated with enalapril, another ACE inhibitor, without the relapse of any adverse reactions.
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004151:Dipeptides / Q000627:therapeutic use*; D004656:Enalapril; D005260:Female; D006801:Humans; D006974:Hypertension, Malignant / Q000150:complications / Q000188:drug therapy*; D007674:Kidney Diseases / Q000150:complications*; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011392:Proline / Q000031:analogs & derivatives*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004151:Dipeptides; D004656:Enalapril; D011392:Proline; D002216:Captopril; D003404:Creatinine; D007703:Peptidyl-Dipeptidase A