Potentiation of carbon tetrachloride hepatotoxicity by beta-phenethyl alcohol.
Carbon tetrachloride (CCl4)-induced hepatotoxicity was potentiated by pretreatment with beta-phenethyl alcohol, abundantly present in sake. The injury was determined by serum GPT levels and histological examination. Similar results were observed in ethanol- and phenobarbital-pretreated rats. Acetaminophen-induced hepatotoxicity was not accentuated by beta-phenethyl alcohol or ethanol pretreatment. The activities of liver microsomal enzymes, such as cytochrome P-450, cytochrome b5 reductase, aniline hydroxylase and aminopyrine demethylase, were not altered in beta-phenethyl alcohol-pretreated rats. Thus, CCl4-induced hepatotoxicity potentiation by beta-phenethyl alcohol administration is postulated to be due to a mechanism other than increased free radical generation.
D000082:Acetaminophen / Q000494:pharmacology; D000410:Alanine Transaminase / Q000097:blood; D000438:Alcohols / Q000494:pharmacology; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D004357:Drug Synergism; D000431:Ethanol / Q000031:analogs & derivatives*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D010626:Phenylethyl Alcohol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000438:Alcohols; D000082:Acetaminophen; D000431:Ethanol; D008748:Methylcholanthrene; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase; D010626:Phenylethyl Alcohol; D010634:Phenobarbital