title: The response of the isolated iris sphincter muscle of various mammalian species to substance P.
abstract: Contractile responses of the isolated iris sphincter muscle from the rabbit, cow, pig, cat, dog, baboon and man to substance P were compared under isotonic conditions using carbachol as a reference standard. Iris preparations from the rabbit, pig and cow showed strong and consistent responses to substance P whilst those from the cat, dog, baboon and human eyes did not contract.
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002415:Cats; D002417:Cattle; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007498:Iris / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D010215:Papio; D011817:Rabbits; D013373:Substance P / Q000494:pharmacology*; D013552:Swine; D014021:Tissue Preservation
chemical_list: D013373:Substance P; D002217:Carbachol