Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection.
Spinal cord sections from mice injected with Theiler's murine encephalomyelitis virus (TMEV) and surviving for 1 year and longer after infection were stained for virus antigen by two immunohistochemical techniques. Virus antigen was detected from 1 to 2 1/2 years after infection, a time when no virus was recovered at an assay sensitivity of 50 plaque-forming units per gram of tissue. The implication this has regarding the detection of a virus in MS is discussed.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D004770:Enterovirus / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000382:microbiology*; D004680:Maus Elberfeld virus / Q000302:isolation & purification*; D051379:Mice; D008815:Mice, Inbred Strains / Q000382:microbiology; D013116:Spinal Cord / Q000382:microbiology*; D013997:Time Factors
D000956:Antigens, Viral