The effect of zinc on [59Fe]lactoferrin binding to blood neutrophilic leucocytes and colostral cells.
Zn2+ inhibits the binding of [59Fe]lactoferrin to neutrophilic leucocytes. The inhibiting effect is proportional to zinc concentration in the range 10-330 mumol/l. Zn2+ inhibits the [59Fe]lactoferrin binding to the colostral cells in the same degree as PMN. The inhibiting effect of Zn2+ on [59Fe]lactoferrin binding to neutrophilic leucocytes is equal to those of non-labelled lactoferrin and transferrin. Fe2+ and Cu2+ does not have such effect on binding of [59Fe]lactoferrin to the PMN leucocytes.
D002462:Cell Membrane / Q000378:metabolism; D003126:Colostrum / Q000378:metabolism*; D006801:Humans; D007504:Iron Radioisotopes; D007700:Kinetics; D007781:Lactoferrin / Q000378:metabolism*; D007782:Lactoglobulins / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology*
D007504:Iron Radioisotopes; D007782:Lactoglobulins; D011956:Receptors, Cell Surface; C038340:lactoferrin receptors; D007781:Lactoferrin; D015032:Zinc