title: Properties of the GABA receptors located on spinal primary afferent neurones and hypophyseal neuroendocrine cells of the rat.
abstract: Electrophysiological techniques have been used to study the pharmacological characteristics of GABA receptors in two in vitro preparations likely to provide the ionic basis for GABAergic inhibition of excitation-secretion coupling. The shortening of Ca2+ spikes duration by GABAB receptors was shown to occur in slow conducting dorsal root ganglion cells, independently of marked depression of inward calcium currents. Ion-selective electrodes (K+ or Ca2+) were used to show the presence of both GABAA and GABAB receptors on the neurosecretory terminals and gland cells from hypophyseal neuro-intermediate lobe (NIL). In this latter preparation, potentiation of hormone release was observed under GABAA receptor activation, whilst inhibition was seen with GABAB agonists.
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D018756:GABA Antagonists; D005727:Ganglia, Spinal / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000502:physiology; D010904:Pituitary Gland, Posterior / Q000294:innervation*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology*; D011963:Receptors, GABA-A; D011984:Sensory Receptor Cells / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D018756:GABA Antagonists; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D011188:Potassium; D002118:Calcium