[Activation of the fibrinolytic system with dehydrochlormethyltestosterone].
4-Chloro-1-dehydro-methyltestosterone (2 mg/kg/die) administered to rats and rabbits for three months increased the spontaneous fibrinolytic activity of blood, the release of plasminogen activator stimulated by venous stasis, and the activator activity in the kidney. Its effect in animal experiments corresponded to that of the steroid stanozolol tested for comparison.
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D008297:Male; D010960:Plasminogen Activators / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013197:Stanozolol / Q000494:pharmacology; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
C000430:D-4-chloro-17 beta-hydroxy-3-oxo-17 alpha-methylandrosta-1,4-diene; D013739:Testosterone; D013197:Stanozolol; D000990:Antithrombin III; D010960:Plasminogen Activators
Experimentelle Untersuchungen zur Aktivierung des fibrinolytischen Systems mit Dehydrochlormethyltestosteron.