title: Postnatal development of rat kidney plasma membrane Na-K-ATPase.
abstract: The postnatal development of the sodium transport mechanism in the rat kidney, as judged by the activity of renal plasma membrane Na-K-ATPase, was studied. Highly purified kidney plasma membranes as verified by electron microscopic and enzyme examinations, were used. Na-K-ATPase activity (mumol Pi/mg protein/h) increases exponentially from 16.9 +/- 1.94 found at birth to the mature level of 43.1 +/- 2.16 reached at the age of 41 days. This finding paralleled our results of SDS-polyacrylamide gel disc electrophoresis, showing a completely differentiated plasma membrane protein structure at birth, the maturation of which proceeds only as quantitative enrichment of some protein fractions in the further postnatal period.
mesh_terms: D000375:Aging; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D005260:Female; D007473:Ion Channels / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008854:Microscopy, Electron; D008970:Molecular Weight; D011247:Pregnancy; D051381:Rats; D011916:Rats, Inbred F344; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D007473:Ion Channels; D008565:Membrane Proteins; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase