[In vivo sensitivity test of anti-cancer drugs against malignant lung tumor xeno-graft].
Using the malignant lung tumor xeno-grafts in Nu-mouse, the sensitivity test of anti-cancer drugs was studied. Furthermore, the correlation between its clinical application and chemotherapeutic effects was also looked up. The results obtained were as follows; Take-rate of human lung cancer in Nu-mouse was 53.7% in primary lung cancer and 92.8% in metastatic ones. Those xeno-grafts were able to use as target cell of this test. In these tests, there were some cases which effective drugs were selected, but a few cases which all drugs were non-response. Response rate of primary lung cancer to treat with effective drugs is 25%, but that of metastatic lung tumors with the same treatment is 57%. Therefore, if the aggressive chemotherapy will be trying for malignant lung tumor, this in vivo sensitivity test to select effective drugs shall be one of the useful test.
D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents