Characterization of antigenic variation among mink enteritis virus isolates.
Three antigenic forms of natural field isolates of mink enteritis virus were revealed with a panel of monoclonal antibodies generated against the closely studied feline panleukopenia virus and canine parvovirus-2 virus. Two types (types 2 and 3) were shown to be closely related by agar-gel precipitin tests and by restriction enzyme mapping. However, types 2 and 3 differed from the type 1 isolates in the same tests. In cross-protection studies, inactivated viral vaccines made from any one of the 3 variant types of mink enteritis virus protected mink against challenge exposure by the homologous, as well as the heterologous, antigenic types.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002415:Cats; D002874:Chromosome Mapping; D004279:DNA, Viral / Q000032:analysis; D000939:Epitopes / Q000235:genetics; D005254:Feline Panleukopenia / Q000276:immunology / Q000382:microbiology*; D028301:Feline Panleukopenia Virus / Q000235:genetics / Q000276:immunology*; D014644:Genetic Variation; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D005779:Immunodiffusion; D008907:Mink; D010321:Parvoviridae / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
D000914:Antibodies, Viral; D004279:DNA, Viral; D000939:Epitopes; D014613:Vaccines, Attenuated; D014765:Viral Vaccines