Inhibition of satiety by a cholecystokinin antagonist is independent of gastric emptying.
The ability of a cholecystokinin antagonist Proglumide to inhibit satiety induced by intraperitoneal injections of cholecystokinin octapeptide (CCK-OP) and bombesin was examined in rats equipped with chronic gastric cannulae. Both CCK-OP and bombesin significantly suppressed sham feeding. Proglumide administered alone did not alter sham feeding but it abolished the suppression of feeding induced by CCK-OP. In contrast, Proglumide did not inhibit the effect of a low dose of bombesin, but partially inhibited satiety induced by a high dose of bombesin, thus confirming our previous findings. These results indicate that the effect of Proglumide is independent of its recently described effects on gastric emptying in rat.
D000818:Animals; D001839:Bombesin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004435:Eating; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D011377:Proglumide / Q000494:pharmacology; D051381:Rats; D012527:Satiation / Q000187:drug effects*; D012528:Satiety Response / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology*
D011377:Proglumide; D012844:Sincalide; D001839:Bombesin