Uterotropic effect of beta-HCH, a food chain contaminant.
The uterotropic effect of beta-HCH was assessed in juvenile female mice and rats. A dose of 50 mg/kg feed over five days gave a significant increase in the uterine weight. The potency of beta-HCH compared to 17 alpha-ethynyloestradiol was about 20 X 10(-6). Based on these and other as yet unpublished observations, it is concluded that beta-HCH has oestrogenic features.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014599:Uterus / Q000033:anatomy & histology*
D004997:Ethinyl Estradiol; D001556:Hexachlorocyclohexane; C023888:beta-hexachlorocyclohexane