title: Retinal neovascularisation arising from hyalinised blood vessels.
abstract: In a retrospective histopathological study of 75 eyes with occlusive retinal vascular disease, intraretinal, preretinal and prepapillary neovascularisation was observed in 76%, 48% and 48%, respectively. The central retinal vein, artery and branch arteries were shown to be occluded in 48, 46 and 6 cases, respectively. Generalised obliterative arteriolovenular sclerosis was observed on 24 occasions; combined stem occlusions of the central retinal vein and artery was found in 33 specimens. A most significant finding was the presence of intramural capillaries within hyalinised retinal vessels in 51 cases (68%). These newly formed capillaries originated from proliferating vascular endothelium; their lumina communicated with the vascular lumen and continued in many instances into congeries of newly formed intra- and preretinal capillaries. The diseased parent vessels showed evidence of plasmatic insudation and transudation (100%) and endothelial proliferation (97%). These phenomena constitute the first stage of a type of retinal neovascularisation which has not hitherto been adequately described.
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000209:etiology / Q000473:pathology*; D002196:Capillaries / Q000473:pathology; D004727:Endothelium / Q000473:pathology; D005260:Female; D005901:Glaucoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000473:pathology*; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology*; D012189:Retrospective Studies