Glycogenosomes in fibres of human normal skeletal muscles. An electron-microscopic study.
Analysis of muscle biopsies from five patients, with no clinical evidence of neuromuscular disorders, showed the presence of membrane-bound structures containing glycogen (glycogenosomes). Occurrence of these structures within human muscle fibres has been usually considered a pathological finding, common to various types of metabolic diseases. Our results provide evidence that glycogenosomes are a normal constituent of human muscle fibre, thereby emphasizing that any relationship between glycogenosomes and a specific pathological condition should be established with great care.
D000009:Abdominal Muscles / Q000033:anatomy & histology; D000328:Adult; D006003:Glycogen / Q000378:metabolism*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D009132:Muscles / Q000033:anatomy & histology*; D009210:Myofibrils / Q000648:ultrastructure; D012508:Sarcolemma / Q000648:ultrastructure; D014617:Vacuoles / Q000648:ultrastructure
D006003:Glycogen