The effect of ethanol administration into the mouse on mast cell histamine releasability in vitro.
Both chronic and acute ethanol administration to the mice (resulting in blood ethanol level 74.0 +/- 8.0 and 79.2 +/- 8.7 mM respectively) induced partial inhibition of in vitro histamine secretion from their peritoneal mast cells challenged with anti-mouse IgE or concanavalin A. An inhibiting effect of chronic ethanol administration was not observed when mast cells were in vitro challenged with calcium ionophore A23187. The results may suggest that ethanol intoxication of the mice inhibits in vitro anaphylactic histamine release from their peritoneal mast cells by the alteration of an early stage of biochemical processes leading to the opening of calcium channels in cell membrane and subsequent mediator secretion.
D000435:Alcoholic Intoxication / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism; D000707:Anaphylaxis / Q000378:metabolism; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D051379:Mice
D003208:Concanavalin A; D007073:Immunoglobulin E; D000001:Calcimycin; D000431:Ethanol