Interferons on the transformation of non-T blood mononuclear leukocytes by Epstein--Barr virus.
The effect of partially purified leukocyte (alpha) and fibroblast (beta)-derived interferons (IFNs) and crude immune (gamma) IFN on the transformation of non-T mononuclear leukocytes by the Epstein--Barr (EBV) virus was studied. The IFN preparations reduced the frequency of cells positive for EBV-specific nuclear antigen but did not significantly prolong the EBV-transformation interval.
D002472:Cell Transformation, Viral / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007700:Kinetics; D009000:Monocytes / Q000187:drug effects / Q000382:microbiology / Q000502:physiology*
D007370:Interferon Type I; D007371:Interferon-gamma