Exacerbation of bronchial asthma following treatment with amiodarone. Demonstration of an antiadrenergic effect in vitro.
We describe a patient with bronchial asthma whose respiratory symptoms worsened during treatment and rechallenge with amiodarone. Laboratory studies on cultured pulmonary cells demonstrated an anti-beta-adrenergic effect of amiodarone not due to inhibition of beta-adrenergic receptor binding. Amiodarone should be used with caution in patients with obstructive pulmonary disease.
D000638:Amiodarone / Q000009:adverse effects* / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy*; D001572:Benzofurans / Q000009:adverse effects*; D001985:Bronchial Provocation Tests; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000187:drug effects; D008875:Middle Aged; D012123:Pulmonary Ventilation; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D001572:Benzofurans; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; D000638:Amiodarone