[Effects of exhaust gas on adrenal cortex activity, general growth and variation of intermediate metabolism in the male rate during a period of growth].
The exhaust gas induces a stressing action, similar to classical type agression: activation of the pituitary adrenal-axis, with increase of relative adrenal weight, and of the rate of corticosterone production. After chronic exposure, deep metabolic changes appear, which reflect an accentuated state of exhaustion of the organism. Moreover perturbation of spermatogenesis with azoospermia is noted. Thus exhaust gas is to be considered as a very potent toxic agent.
D000302:Adrenal Cortex / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002248:Carbon Monoxide / Q000097:blood; D003345:Corticosterone / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006128:Growth / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D001335:Vehicle Emissions / Q000633:toxicity*
D001798:Blood Proteins; D008055:Lipids; D001335:Vehicle Emissions; D002248:Carbon Monoxide; D006003:Glycogen; D003345:Corticosterone
Incidence du gaz d'échappement sur l'activité corticosurrénalienne, la croissance générale et la variation de certains métabolismes intermédiaires chez le rat mâle en période de croissance.