title: Transcription of the mouse dihydrofolate reductase gene proceeds unabated through seven polyadenylation sites and terminates near a region of repeated DNA.
abstract: We observed equimolar transcription throughout the 35-kilobase mouse dihydrofolate reductase structural gene. Transcription termination occurred within a discrete region (900 base pairs) located 1 kilobase beyond the last of seven functional polyadenylation sites and near a repetitive DNA sequence element. The results imply that a distinct genetic signal may be associated with the process of transcription termination.
mesh_terms: D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000032:analysis*; D005796:Genes; D051379:Mice; D011061:Poly A / Q000378:metabolism*; D012313:RNA / Q000032:analysis / Q000378:metabolism*; D012333:RNA, Messenger; D012091:Repetitive Sequences, Nucleic Acid; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D011061:Poly A; D012313:RNA; D004247:DNA; D013762:Tetrahydrofolate Dehydrogenase