[Heterogeneity of monospecific antibodies to the hemagglutinin of influenza virus H3N2 studied by radioimmunological analysis].
Heterogeneity of antibodies against influenza virus hemagglutinin has been confirmed. Various subpopulations of antibodies to the A/Khabarovsk/15/76 hemagglutinin were demonstrated some of which showed greater affinity to MRC-11 hemagglutinin than to the HA of the strain inducing this antibody synthesis. Apparently subpopulations of antibodies with low affinity to their "own" epitopes in the hemagglutinin-immunogen may develop which, however, may show a sufficiently high affinity to these epitopes in hemagglutinins of other strains.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000915:Antibody Affinity; D000918:Antibody Specificity; D000939:Epitopes / Q000276:immunology; D006389:Hemagglutinins, Viral / Q000276:immunology*; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000276:immunology*; D011863:Radioimmunoassay; D051381:Rats
D000914:Antibodies, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral
Izuchenie geterogennosti monospetsificheskikh antitel k gemaggliutininu virusa grippa H3N2 metodom radioimmunologicheskogo analiza.