[Alteration of peripheral blood lymphocyte subsets in the patients with ovarian cancer before and after chemotherapy].
Peripheral blood lymphocyte subsets of 8 patients with ovarian cancer were analyzed before and after chemotherapy by using monoclonal antibody (OKT series) and laser flow cytometer (Spectrum III). The following results were obtained: There was no significant difference in the distribution of OKT3+ and 11+ cells before and after chemotherapy, and between the patient and the control groups. OKT4+ cells were significantly decreased in number after chemotherapy in the patient group when the results were compared with the control (p less than 0.001) and the pretreatment (p less than 0.05) groups respectively. OKT8+ cells were more markedly increased in number after chemotherapy in the patient group (p less than 0.05) than in the control group. OKIal+ cells were more increased in number after chemotherapy in the patient group (p less than 0.01) than the control group. The OKT4+/OKT8+ ratio in the patient group was significantly decreased after chemotherapy when the value was compared with the control (p less than 0.001) and the pretreatment (p less than 0.05) groups.
D002288:Adenocarcinoma, Mucinous / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003536:Cystadenocarcinoma / Q000276:immunology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013724:Teratoma / Q000276:immunology
D000911:Antibodies, Monoclonal