[Detection of the virus-specific antigens of adenoviruses and herpes simplex virus in patients with malignant genital diseases].
The possibility of detecting virus-specific antigens in women with various pathological changes of the genitalia (cancer and pre-cancer conditions) was demonstrated. Comparative examinations of specimens from patients with cancer diseases of the genitalia for the presence of structural and virus-induced early antigens of HSV-2 demonstrated immunofluorescence test (IFT) to be the diagnostic test for the detection of HSV antigens in patients with cervical carcinoma. The rate of virus-induced antigen findings in the group of patients with cervical carcinoma was 51.6%, in precancer conditions, 31.7%, in recurrent genital herpes, 78.5%, in the control group of healthy women, 5%, by the IFT. The detection of virus-specific adenovirus and herpes antigens in human tumors is of interest for further investigation of a possible role of these viruses in the generation of malignant neoplasias and for the development of methods for specific immunodiagnosis.
D000260:Adenoviruses, Human / Q000276:immunology*; D000956:Antigens, Viral / Q000032:analysis*; D000939:Epitopes / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D005833:Genital Neoplasms, Female / Q000276:immunology*; D006558:Herpes Genitalis / Q000276:immunology; D006801:Humans; D008297:Male; D011230:Precancerous Conditions / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology*; D014626:Vaginal Smears
D000956:Antigens, Viral; D000939:Epitopes
Obnaruzhenie virusspetsificheskikh antigenov adenovirusov i virusa prostogo gerpesa u bol'nykh so zlokachestvennymi zabolevaniiami genitaliĭ.