Influence of azacytidine on the induction of tyrosine aminotransferase and the NAD metabolism in rat liver.
5-Azacytidine was found to inhibit the induction of tyrosine aminotransferase caused by L-tyrosine and hydrocortisone. The inhibitory effect can be overcome by L-methionine. There was only a slight inhibition of the tryptophan induction by 5-azacytidine in normal animals 4 hr after the administration of tryptophan. At 8 and 12 hr, a superinduction could be observed. The NAD content in adrenalectomized animals increased after application of tryptophan and 5-azacytidine. There was a slight inhibition of ADPR transferase in the rat liver.
D000315:Adrenalectomy; D000818:Animals; D001374:Azacitidine / Q000494:pharmacology*; D002467:Cell Nucleus / Q000201:enzymology; D004790:Enzyme Induction; D006854:Hydrocortisone / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D051381:Rats; D014364:Tryptophan / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D009243:NAD; D014364:Tryptophan; D014444:Tyrosine Transaminase; D001374:Azacitidine; D006854:Hydrocortisone