Vitamin D3 active metabolites as a countermeasure against disorders of calcium-phosphorus metabolism in hypokinetic rats.
Male Wistar rats that were experimentally hypokinetic were fed 24,25(OH)2D3 or 1,25(OH)2D3 separately or in combination to determine the effect on bone growth and on bone formation and resorption. It was shown that these parameters of bone metabolism are influenced by these metabolites of vitamin D3 by their effect on bone sensitivity to their activity and perhaps in the regulation of bone histogenesis.
D015650:24,25-Dihydroxyvitamin D 3; D000818:Animals; D001846:Bone Development / Q000187:drug effects; D002117:Calcitriol / Q000494:pharmacology; D002128:Calcium Metabolism Disorders / Q000503:physiopathology*; D002762:Cholecalciferol / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000494:pharmacology; D004838:Epiphyses / Q000254:growth & development; D005269:Femur / Q000254:growth & development; D006132:Growth Plate / Q000473:pathology; D007103:Immobilization; D008297:Male; D009068:Movement; D010760:Phosphorus Metabolism Disorders / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D004100:Dihydroxycholecalciferols; D002762:Cholecalciferol; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol