Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene.
Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.
D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000235:genetics*; D001483:Base Sequence; D002460:Cell Line; D003488:Cyanogen Bromide; D017977:Deltaretrovirus / Q000235:genetics* / Q000276:immunology; D005814:Genes, Viral; D006801:Humans; D010446:Peptide Fragments; D015534:Trans-Activators; D014764:Viral Proteins / Q000235:genetics*
D000956:Antigens, Viral; D010446:Peptide Fragments; D015534:Trans-Activators; D014764:Viral Proteins; D003488:Cyanogen Bromide