[Lymphocyte heterogeneity of the T system: characterization of an allotypic antiserum recognizing a sub-species antigenic determinant in non-human primates].
To determine the membrane properties in T-lymphocyte population from Saguinus primates or lymphoblastoid cell lines of the same origin, an allotypic antiserum was prepared inoculating two Saguinus illigeri with 3.5 x 10(10) viable 70N2 cells obtained in-vitro, from a lymphoma induced by inoculation of Herpesvirus Saimiri in a Saguinus oedipus. The 70N2 cells carried the virus genome in an episomal way; it did not produce infectious virus and it formed spontaneous rosettes (99%) with sheep erythrocytes. The resulting allotypic antiserum inhibited the formation of E rosettes and specifically reacted with lymphoblastic T-cell lines and peripheral lymphocytes of Saguinus oedipus while it did not cross react with these cells or peripheral lymphocytes of S. illigeri or nigrifons, S. jacchus, Saimiri sciureus , Papio Sp. and human primates. These results show that two antigenic populations exist within Saguinus T-lymphocytes; one is common to all members of the species and the other is specific for subspecies related to the spontaneous rosette receptors and it is present in lymphoblastic cell lines-T of the same origin.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D002143:Callitrichinae / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D012397:Rosette Formation; D012452:Saguinus / Q000276:immunology*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000954:Antigens, Surface; D000939:Epitopes; D007518:Isoantibodies
Heterogeneidad linfocitaria del sistema T: caracterización de un antisuero alotípico que reconoce un determinante antigénico de sub-especie en primates no-humanos.