Prostaglandin E1: cAMP level and radiosensitivity of cultured B-82 cells.
In experiments on mice L-fibroblasts, clone B-82, was shown that incubation of the cells for 5 minutes with prostaglandin E1 before the X-irradiation leads to a decrease in radiosensitivity of B-82 cells. Radioprotective concentrations of prostaglandin E1 caused an increase in the intracellular cAMP content.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000527:Alprostadil; D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D000242:Cyclic AMP / Q000032:analysis*; D004789:Enzyme Activation; D005347:Fibroblasts / Q000032:analysis / Q000187:drug effects*; D051379:Mice; D011458:Prostaglandins E / Q000494:pharmacology*; D011835:Radiation Protection
D011458:Prostaglandins E; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000527:Alprostadil