Biochemical and functional evidence for a marked dopamine releasing action of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) in mouse brain.
The acute effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) on mouse central monoaminergic neurons were investigated. In striatum, two hours after the injection of NMPTP (50 mg/kg s.c.) there was a seven-fold increase in 3-methoxytyramine that coincided with a 55% decrease in dopamine. In addition, the same dose of NMPTP caused an acute increase in mouse motor activity; this effect was antagonized by haloperidol or by pretreatment with reserpine. These data indicate that NMPTP initially causes a pronounced release of dopamine into the extraneuronal space.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects*; D004298:Dopamine / Q000031:analogs & derivatives* / Q000032:analysis*; D006719:Homovanillic Acid / Q000032:analysis; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D012701:Serotonin / Q000032:analysis
D011725:Pyridines; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; C001746:3-methoxytyramine; D004298:Dopamine; D006719:Homovanillic Acid