Involvement of 16S ribosomal RNA in resistance of the aminoglycoside-producers Streptomyces tenjimariensis, Streptomyces tenebrarius and Micromonospora purpurea.
Resistance to aminoglycoside antibiotics in Micromonospora purpurea (the producer of gentamicin C complex), Streptomyces tenebrarius (the nebramycin producer) and Streptomyces tenjimariensis (which makes istamycin) occurs at the level of the ribosome. Reconstitution analysis has revealed, in each case, that 16S rRNA plays a critical role in determining such resistance.
D000617:Aminoglycosides / Q000096:biosynthesis; D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D008847:Micromonospora / Q000378:metabolism / Q000502:physiology*; D014176:Protein Biosynthesis / Q000187:drug effects; D012329:RNA, Bacterial / Q000502:physiology*; D012335:RNA, Ribosomal / Q000502:physiology*; D013302:Streptomyces / Q000378:metabolism / Q000502:physiology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D012335:RNA, Ribosomal