[Brain beta-adrenergic and GABA-ergic receptors in rats after exposure to high doses of ionizing radiation].
The radioactive ligands, [3H]dihydroalprenolol and [3H]muscimol, were used to estimate the condition of beta-adrenoreceptors of the brain cortex and GABA-receptors of the cerebellum during transient neurologic disorders caused by irradiation of rats with high-energy (20 MeV) electrons of 200 Gy. No significant changes were observed in the GABA-ergic brain system while the changes in beta-adrenoreceptors of the brain were pronounced and manifested by the loss by the receptors of their ability to bind the specific ligand, dihydroalprenolol. The changes observed were reversible and correlated with the development of neurologic disorders.
D000818:Animals; D001921:Brain / Q000528:radiation effects*; D002531:Cerebellum / Q000528:radiation effects; D002540:Cerebral Cortex / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D008024:Ligands; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology / Q000378:metabolism; D011832:Radiation Injuries / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000528:radiation effects*; D011956:Receptors, Cell Surface / Q000528:radiation effects*; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid / Q000528:radiation effects*
D008024:Ligands; D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid
Sostoianie beta-adrenergicheskikh i GAMK-ergicheskikh retseptorov mozga krys posle vozdeĭstviia vysokikh doz ioniziruiushcheĭ radiatsii.