The ultrastructure of the enlarged hepatocytes induced in rats with a single oral dose of retrorsine, a pyrrolizidine (Senecio) alkaloid.
D000225:Adenine / Q000378:metabolism; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D002247:Carbon Isotopes; D002467:Cell Nucleus; D004247:DNA / Q000096:biosynthesis; D004721:Endoplasmic Reticulum; D006056:Golgi Apparatus; D006529:Hepatomegaly / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology*; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008297:Male; D008854:Microscopy, Electron; D010947:Plants, Toxic; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D012674:Senecio
D000470:Alkaloids; D002247:Carbon Isotopes; D012313:RNA; D004247:DNA; D000225:Adenine