Enkephalinergic markers in substantia nigra and caudate nucleus from Parkinsonian subjects.
Marked reductions in opiate receptor binding (-42%), "enkephalinase" activity (-39%), and Met5-enkephalin levels (-72%) accompanied the well-established dopamine depletion in the substantia nigra pars compacta of Parkinsonian subjects. In contrast, enkephalinergic markers were not significantly modified in caudate nucleus.
D000368:Aged; D002421:Caudate Nucleus / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000378:metabolism*; D006801:Humans; D015260:Neprilysin; D009928:Organ Specificity; D010300:Parkinson Disease / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D012016:Reference Values; D013378:Substantia Nigra / Q000378:metabolism*
D011957:Receptors, Opioid; D004744:Enkephalin, Methionine; D010450:Endopeptidases; D015260:Neprilysin; D004298:Dopamine