Cell mediated immunity to polio antigens in the early stage of acute poliomyelitis.
Specific cell-mediated immunity to polio antigens in 22 children suffering from acute paralytic poliomyelitis was investigated by the macrophage migration inhibition factor (MIF) technique. A positive response was observed in 9 of the 11 patients tested 1-4 days after the onset of the paralysis, and in 6 of the 8 patients tested between 15-90 days. In one case, the response was positive before paralysis became evident. In the 8 patients tested 90-360 days after paralysis, only three gave positive results. No response was observed in 34 of 39 healthy children tested 1-3 months after having received oral polio vaccine, or in 30 healthy adults.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000276:immunology*; D002464:Cell Migration Inhibition; D002675:Child, Preschool; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D008264:Macrophages / Q000276:immunology; D011051:Poliomyelitis / Q000276:immunology*; D017955:Poliovirus / Q000276:immunology*; D011055:Poliovirus Vaccine, Oral / Q000276:immunology
D000956:Antigens, Viral; D011055:Poliovirus Vaccine, Oral