Beta-adrenoceptor binding defects in cell lines from families with manic-depressive disorder.
Binding of 125I-iodohydroxybenzylpindolol to beta-adrenoceptors has been examined in lymphoblastoid cell lines from members of 5 families affected by manic-depressive disorder. Cell lines from 6 manic-depressives, 7 unaffected relatives and 11 non-psychiatric controls were examined. Binding was reduced to less than half of control values in cell lines from 4 out of 6 manic-depressives and only 1 out of 18 unaffected relatives or controls. All the cell lines with reduced beta-adrenoceptor binding came from 3 families; members of the remaining 2 families showed normal binding. These findings suggest that genetic heterogeneity is present in manic-depressive disorder and that a beta-adrenoceptor defect may influence genetic susceptibility to the disorder.
D015720:5'-Nucleotidase; D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism; D001714:Bipolar Disorder / Q000235:genetics*; D002460:Cell Line; D005260:Female; D006801:Humans; D008297:Male; D009708:Nucleotidases / Q000378:metabolism; D010042:Ouabain / Q000378:metabolism; D010375:Pedigree; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000235:genetics* / Q000378:metabolism
D011943:Receptors, Adrenergic, beta; C011878:iodohydroxybenzylpindolol; D010042:Ouabain; D010869:Pindolol; D009708:Nucleotidases; D015720:5'-Nucleotidase