Amiodarone pulmonary toxicity.
Numerous cytoplasmic lamellar bodies were seen in many cell types in an open lung biopsy from a patient on amiodarone therapy. These membrane-bound lamellar bodies were characterized by distinct, concentric parallel membranes and peripheral granular densities. Their morphology and distribution suggest a metabolic disorder of phospholipid degradation induced by this drug. The differential diagnosis of lamellar body accumulation in the lung is discussed. This case emphasizes the desirability for ultrastructural study of lung biopsies in such potentially reversible lung disease.
D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001572:Benzofurans / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008171:Lung Diseases / Q000139:chemically induced*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000187:drug effects
D001572:Benzofurans; D000638:Amiodarone