title: Comparison of prophylactic antibiotic regimens in patients undergoing vascular surgery.
abstract: An unacceptably high infection rate in patients undergoing vascular surgery prompted two studies on these patients. The first study confirmed the problem and described antibiotic usage which was not standardized. A second double blind randomized study compared antibiotic usage in two groups of patients, receiving vein grafts or synthetic grafts. Patients receiving vein grafts were randomized either to placebo or cefazolin 2 g 1 h pre-operatively and every 6 h for 48 h. Patients receiving synthetic grafts were randomized either to cefazolin 1 g or to cefazolin 2 g 1 h pre-operatively and every 6 h for 48 h. Four of 50 vein graft patients developed a purulent discharge. Two of these infected patients received placebo and two received the cefazolin 2 g protocol. Of 90 patients receiving a synthetic graft, four became infected. Three patients were randomized to the cefazolin 1 g protocol and one to the cefazolin 2 g protocol. No statistically significant differences were observed.
mesh_terms: D000328:Adult; D001807:Blood Vessel Prosthesis; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use*; D003428:Cross Infection / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014656:Vascular Surgical Procedures; D014680:Veins / Q000637:transplantation
chemical_list: D002437:Cefazolin