[Isolation and characterization of retroviruses expressed in murine osteosarcomas induced by 90Sr].
The induction of osteosarcomas with 90Sr in CF1 mice is associated with the expression of ecotropic type-C RNA viruses devoid of sarcomatogenic activity. In contrast, the FBR murine osteosarcoma virus complex, isolated from a 90 Sr-induced osteosarcoma of a X/Gf mouse [M. Finkel et al. (1)], causes the rapid appearance of osteosarcomas in newborn mice and transforms fibroblasts in vitro. The transforming capacity of FBR murine sarcoma virus has been associated as an oncogene homologous to v-fos.
D000818:Animals; D000831:Animals, Newborn; D002471:Cell Transformation, Neoplastic; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009381:Neoplasms, Radiation-Induced / Q000382:microbiology*; D009857:Oncogenes; D012516:Osteosarcoma / Q000382:microbiology* / Q000648:ultrastructure; D009053:Sarcoma Viruses, Murine / Q000235:genetics / Q000302:isolation & purification*; D013324:Strontium
D013324:Strontium
Isolement et caractérisation de rétrovirus exprimés dans les ostéosarcomes murins induits par le 90Sr.