title: Effects of accelerating growth on the onset of puberty in male mice.
abstract: Sexual maturation was evaluated in male mice subjected to prenatal and preweaning overnutrition induced by reduction of litter size in embryonic and post-natal life. From birth to adulthood body weight was higher in overfed males than in controls. Plasma and testicular testosterone levels followed a similar pattern in normally fed and overfed males. Adult gonadotrophin levels were attained at 30 (FSH) and 40 (LH) days in controls and as soon as 20 days in overfed males. First fertile matings occurred at the same age in both groups. Overnourished males attained puberty when weighing considerably more than controls (34.7 +/- 0.4 vs. 29.4 +/- 0.3 g). The 30-day-old overfed males, which have attained the critical pubertal body weight of controls, were sexually immature. The data showed that in male mice puberty does not seem to be triggered by the attainment of a critical body weight.
mesh_terms: D000818:Animals; D001835:Body Weight; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000378:metabolism; D006128:Growth; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D009747:Nutritional Physiological Phenomena; D009929:Organ Size; D011247:Pregnancy; D012669:Seminal Vesicles / Q000254:growth & development; D012741:Sexual Maturation; D013737:Testis / Q000254:growth & development / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
chemical_list: D006062:Gonadotropins; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone