Pharmacological interaction of the effects of delta 9-trans-tetrahydrocannabinol and cannabidiol on serum corticosterone levels in rats.
The pharmacological interaction of the effects of delta 9-trans-tetrahydrocannabinol (delta 9-THC) and cannabidiol (CBD) on serum corticosterone levels in rats was studied in two experimental situations: simultaneous administration of the two cannabinoids, or administration of one followed by the other 24 hr later. Forty-five min after administration, both delta 9-THC (1, 2 and 4 mg/kg) and CBD (10, 30 and 60 mg/kg) induced a dose-dependent increase in corticosterone levels. The effect of the mixture delta 9-THC (2 mg/kg) with CBD (10, 30 and 60 mg/kg) did not differ significantly from that produced by CBD alone. We also observed that CBD (30 mg/kg), 24 hr after administration, potentiated the effect of delta 9-THC (2 mg/kg) even though it had no effect on corticosterone levels. This delayed interference of CBD with delta 9-THC effects was attributed to a pharmacokinetic interaction between the two cannabinoids.
D000818:Animals; D002185:Cannabidiol / Q000008:administration & dosage / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002186:Cannabinoids; D002185:Cannabidiol; D013759:Dronabinol; D003345:Corticosterone