Addiction liability of albino rats: breeding for quantitive differences in morphine drinking.
Selective breeding produced two strains of rats that differ in their susceptibility to morphine addiction. Inbreeding the more susceptible rats in an unselected population produced susceptible offspring; inbreeding resistant rats produced resistant offspring. Further selection and inbreeding increased the strain difference in the F(2) and F(3) generations. The F(3) generation also differed in their susceptibility to alcohol addiction.
D000437:Alcoholism / Q000235:genetics*; D000818:Animals; D001522:Behavior, Animal; D005260:Female; D005823:Genetics; D006801:Humans; D008297:Male; D009021:Morphine Dependence / Q000235:genetics*; D051381:Rats; D013045:Species Specificity