title: Chemotactic factor-induced enhancement of the binding of human immunoglobulin classes and subclasses to neutrophils and eosinophils.
abstract: Sheep erythrocytes (E) coated with either human IgG1, IgG2, IgG3 or IgG4 myeloma proteins formed rosettes with human neutrophils and eosinophils. Prior incubation with the chemotactic agents f-met-leu-phe or leukotriene B4 enhanced neutrophil and eosinophil E-IgG1 rosettes in a time- and dose-dependent fashion. There were comparable increases in neutrophil and eosinophil f-met-leu-phe-induced rosettes with either E-IgG1, E-IgG2, E-IgG3 or E-IgG4 whereas this agent did not appear to influence E-IgA1, E-IgD, E-IgM or E-IgE binding to these granulocytes. These studies indicate that human neutrophil and eosinophil IgG (Fc) receptors are enhanced by chemotactic agents in a similar way to that previously described for complement receptors.
mesh_terms: D004804:Eosinophils / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology*; D007975:Leukotriene B4 / Q000494:pharmacology*; D009194:Myeloma Proteins / Q000276:immunology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009504:Neutrophils / Q000276:immunology*; D012397:Rosette Formation
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; D009194:Myeloma Proteins; D007975:Leukotriene B4; D009240:N-Formylmethionine Leucyl-Phenylalanine