"Original antigenic sin" phenomenon in experimental flavivirus infections of guinea pigs: studies by enzyme-linked immunosorbent assay.
Guinea pigs were sequentially infected with two closely related flavivituses (Japanese encephalitis and West Nile viruses), and their antibody responses were studied both by enzyme-linked immunosorbent assay (ELISA) and hemagglutination-inhibition (HI). The results by ELISA always showed "original antigenic sin" responses: antibody activity of sera after the second infection was higher to the first infecting virus than to the second infecting virus. However, the results obtained by HI were variable.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000276:immunology*; D004664:Encephalitis Virus, Japanese / Q000276:immunology; D004672:Encephalitis, Japanese / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005416:Flavivirus / Q000276:immunology*; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D014036:Togaviridae Infections / Q000276:immunology*; D014901:West Nile Fever / Q000276:immunology; D014902:West Nile virus / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral