title: [Role of the sympathetic nervous system in adaptive changes in brain energy metabolism during ischemia and in the postischemic period].
abstract: Ischemia of the rat brain was induced for 15 min, 2 and 4 hrs, 1 and 3 days. The studies were performed during the ischemia as well as within 15 min and 2 hrs after cerebral blood flow restoration. The same experiments were carried out in animals with removed upper cervical sympathetic ganglia. During ischemia phasic changes of the energy metabolism were revealed (dissociation of oxydation and phosphorylation) as well as of activity of cerebral enzymes and water content in the brain tissue (ischemic and postischemic oedema). Changes of cAMP and cGMP contents corresponded to the above changes which reflected the adren- and cholinergic phases of adaptation. Sympathectomy led to similar though less obvious changes of the metabolism. The ischemia in desympathized animals led to greater changes of metabolism spreading beyond the adaptive shifts to an overtension of adrenergic compensatory mechanisms, increasing the mortality rate from 45 to 70%. The adaptive-trophic effect of the sympathetic innervation seems to tell on the optimal relations between adren- and cholinergic phases of compensation in the brain ischemia. Desympathization makes the effects of brain ischemia more grave.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008297:Male; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase; D006152:Cyclic GMP
vernacular_title: Rol' simpaticheskoĭ nervnoĭ sistemy v adaptivnykh izmeneniiakh énergeticheskogo metabolizma mozga pri ego ishemii i v postishemicheskom periode.