title: Humoral factors in regulation of compensatory renal hypertrophy.
abstract: Compensatory renal hypertrophy in transplanted kidneys shows that the major regulators are humoral. Crosscirculation experiments are confirmatory indicating further that the regulators are short-lived and must be consistently present during the early phases of hypertrophy. Controls are difficult to achieve in other systems; variables relate to nutrition, means of assay, pharmacokinetics, and abnormalities produced by the experimental model itself. A simple hypothesis to account for the events precipitating renal hypertrophy might integrate the onsets of renal hyperemia soon after contralateral nephrectomy with the activation of pre-existing stimulators specific for the kidney.
mesh_terms: D000818:Animals; D004247:DNA / Q000032:analysis; D006133:Growth Substances / Q000502:physiology*; D006984:Hypertrophy; D036341:Intercellular Signaling Peptides and Proteins; D007668:Kidney / Q000473:pathology*; D016030:Kidney Transplantation; D008940:Mitotic Index; D012313:RNA / Q000032:analysis; D012079:Renal Circulation
chemical_list: D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; C010320:renotropins; D012313:RNA; D004247:DNA