[Biological activity of transition metal complexes. 5. Effect of dimethyl sulfoxide on the cytotoxic, antiviral and antitumoral properties of cis-dichlorodiammineplatinum (II): "cisplatin"].
In water or dimethyl sulfoxide solutions cis-platinum is subject of time depending solvolytic reactions leading to compounds with different biological effectivity. Whereas the inactivation of vaccinia, vesicular stomatitis and adeno virus type 5 was not changed if dimethyl sulfoxide or dimethyl formamide instead of destilled water were used as solvents, long time stored solutions of cis-platinum in dimethyl sulfoxide were tolerated by cells cultivated in vitro in 8-25 times higher concentrations in comparison with a freshly solved preparation. Their antiviral effectivity was maintained. On the other hand experiments with mice showed that simultaneously with the decrease of toxicity of an aged cis-platinum solution in DMSO also its antileukemic activity disappeared. In a 5 weeks old cis-platinum solution in destilled water antitumor activity was preserved in spite of enhanced toxicity.
D000260:Adenoviruses, Human / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D002945:Cisplatin / Q000494:pharmacology* / Q000627:therapeutic use; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D004361:Drug Tolerance; D005260:Female; D007739:L Cells / Q000187:drug effects; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012996:Solutions; D014616:Vaccinia virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D012996:Solutions; D002945:Cisplatin; D004121:Dimethyl Sulfoxide
Uber biologische Wirkungen von Koordinationsverbindungen der Ubergangsmetalle. 5. Zum Einfluss von Dimethylsulfoxid auf die zytotoxischen, antiviralen und antitumoralen Eigenschaften von Cis-dichloro-diammin-platin (II): "Cis-Platin".