Effect of PSK on interferon production in tumor-bearing mice.
The effect of PSK on the depressed interferon (IF) production in tumor-bearing mice was studied. In tumor-bearing mice, in vitro IF production by spleen cells treated with polyinosinic-polycytidylic acid (poly I:C) was remarkably inhibited. However, these inhibitions were prevented by the intraperitoneal (ip) administration of PSK. Mice were inoculated intravenously (iv) with poly I:C-treated spleen cells, administered with PSK ip at 3 days after the tumor inoculation. When PSK was not given, poly I:C-treated spleen cells did not show an inhibitory effect on tumor growth. In mice given PSK ip, poly I:C-treated spleen cells exerted slightly inhibiting effects on tumor growth. These results suggest that PSK prevented such a modulation in tumor-bearing mice.
D000818:Animals; D005260:Female; D007111:Immunity, Cellular; D007372:Interferons / Q000096:biosynthesis*; D017710:Lymphocyte Transfusion; D008264:Macrophages / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*; D011070:Poly I-C / Q000494:pharmacology; D011509:Proteoglycans / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D011509:Proteoglycans; C010770:polysaccharide-K; D007372:Interferons; D011070:Poly I-C