Identification of immunoreactive thyrotropin-releasing hormone in human neoplasia.
Immunoreactive TRH (IR-TRH) was identified in extracts derived from seven human cancer tissues, including two oat cell carcinomas. The IR-TRH concentrations ranged from 29-189 pg/g. Tumor IR-TRH exhibited immunological identity with synthetic pyroglu-his-proamide and coeluted with synthetic [3H]TRH after high pressure liquid chromatography on a mu Bondapak C-18 column. These data extend the number of hypothalamic peptide hormones identified in human neoplastic tissues.
D000230:Adenocarcinoma / Q000032:analysis; D001943:Breast Neoplasms / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000032:analysis; D002846:Chromatography, Affinity; D005706:Gallbladder Neoplasms / Q000032:analysis; D006801:Humans; D007890:Leiomyosarcoma / Q000032:analysis; D008175:Lung Neoplasms / Q000032:analysis; D008545:Melanoma / Q000032:analysis; D009369:Neoplasms / Q000032:analysis*; D011863:Radioimmunoassay; D013973:Thyrotropin-Releasing Hormone / Q000032:analysis*
D013973:Thyrotropin-Releasing Hormone