Effects of naloxone on patients with panic attacks.
To determine whether endogenous opiates are involved in panic anxiety, the authors challenged 12 patients with panic attacks with intravenous naloxone hydrochloride alone or combined with sodium lactate. Naloxone did not produce panic attacks or alter responses to lactate.
D000328:Adult; D000379:Agoraphobia / Q000139:chemically induced / Q000503:physiopathology; D001008:Anxiety Disorders / Q000139:chemically induced / Q000503:physiopathology*; D004723:Endorphins / Q000502:physiology*; D005239:Fear / Q000187:drug effects*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007773:Lactates / Q000008:administration & dosage / Q000494:pharmacology; D019344:Lactic Acid; D008297:Male; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D010200:Panic / Q000187:drug effects*; D011957:Receptors, Opioid / Q000187:drug effects
D004723:Endorphins; D007773:Lactates; D011957:Receptors, Opioid; D019344:Lactic Acid; D009270:Naloxone