title: Characteristics of membrane channels induced by acetylcholine at frog muscle-tendon junctions.
abstract: The membrane at the tendinous ends of frog muscle fibres has acetylcholine (ACh) receptors that are blocked by alpha-bungarotoxin. The properties of ACh-activated channels in the myotendinous region were investigated by noise analysis. These channels displayed the same characteristics in normal, denervated and reinnervated muscles. The mean lifetime and conductance of ACh-induced channels at the myotendinous junction resembled those of channels at the normal neuromuscular junction. Both channels opened with a lifetime shorter than that of extrajunctional receptors. Channels of short lifetime could be detected at distances of several hundred micrometres from the tendon junction. The similarity of ACh-activated channels at neuromuscular and myotendon junctions was found both in the fast, 'singly' innervated sartorius and cutaneous pectoris muscle and in the intermediate, multiply innervated submaxillaris muscle.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials; D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology; D004553:Electric Conductivity; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials; D009121:Muscle Denervation; D009132:Muscles / Q000502:physiology*; D009416:Nerve Regeneration; D011896:Rana temporaria; D011950:Receptors, Cholinergic / Q000187:drug effects; D013710:Tendons / Q000502:physiology*
chemical_list: D002038:Bungarotoxins; D007473:Ion Channels; D011950:Receptors, Cholinergic; D000109:Acetylcholine