Influence of cefmenoxime, ceftriaxone, latamoxef, and ceftazidime on the lysis of Klebsiella pneumoniae: a light and electron microscopic study.
The influence of antibiotics on the morphologic alterations of the cell wall of Klebsiella pneumoniae serotype K 17 has been studied by electron microscopy as well as by phase-contrast microscopy. Ceftazidime, cefmenoxime, ceftriaxone, and latamoxef were the antibiotics used. The effect of each concentration between 0.03 and 1,024 mg/liter was investigated on 5 X 10(7) bacteria per milliliter. Two different reactions could be detected: ceftazidime and latamoxef produced at first long forms and suddenly lysis; cefmenoxime and ceftriaxone produced at first long forms, later spherical forms, and then gradually lysis.
D001433:Bacteriolysis / Q000187:drug effects; D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology*; D002443:Ceftriaxone; D002473:Cell Wall / Q000187:drug effects; D003470:Culture Media; D007711:Klebsiella pneumoniae / Q000166:cytology / Q000187:drug effects*; D007739:L Cells / Q000166:cytology; D008854:Microscopy, Electron; D008858:Microscopy, Phase-Contrast; D009070:Moxalactam / Q000494:pharmacology*; D013194:Staining and Labeling
D003470:Culture Media; D002443:Ceftriaxone; D002442:Ceftazidime; D015281:Cefmenoxime; D002439:Cefotaxime; D009070:Moxalactam