[Dynamics of various peptide hormone receptors in human placental cell membranes].
The action of peptide hormone receptors on the cell membranes and the cyclic-AMP in its post receptor system dynamics was studied. [Results] Receptors for hCG-LH, hPL-hGH, ACTH and Insulin were found in the placental cell membranes but receptors for FSH and PRL were not found. The possibility was suggested that the cyclic-AMP was the second messenger in the receptor system for hCG-LH, hPL and ACTH. The differences between normal placental cell membranes and hydatidiform mole were studied from the point of view of the receptor level. Receptors on molar trophoblast for hCG-LH, hPL-hGH and ACTH increased about two fold to three fold over those on normal trophoblast. The presence of receptors for hCG-LH, hPL and ACTH was confirmed also in GCH-1 (gestational choriocarcinoma cell line). The possibility is shown that the placenta has an auto regularity system in its own tissue throughout the various peptide hormones receptors such as hCG-LH and hPL.
D002824:Chorionic Villi / Q000032:analysis*; D000242:Cyclic AMP / Q000032:analysis; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000032:analysis; D010920:Placenta / Q000032:analysis*; D011247:Pregnancy; D011972:Receptor, Insulin / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis*; D018043:Receptors, Corticotropin; D011974:Receptors, LH; D011981:Receptors, Prolactin
D011956:Receptors, Cell Surface; D018043:Receptors, Corticotropin; D011974:Receptors, LH; D011981:Receptors, Prolactin; D000242:Cyclic AMP; D011972:Receptor, Insulin