Quantitative aspects of the release of leukocyte pyrogen from rabbit blood incubated with endotoxin.
This paper describes the relations between the endotoxin concentration and leukocyte pyrogen yield when endotoxin is incubated with whole rabbit blood for 24 hr. The results provide strong evidence for the view that leukocyte pyrogen is not modified endotoxin, and also show that the simplified assay method described in the previous paper works reasonably well.
D000818:Animals; D001681:Biological Assay; D004731:Endotoxins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007962:Leukocytes / Q000378:metabolism*; D011511:Proteus; D011749:Pyrogens / Q000097:blood*; D011817:Rabbits
D004731:Endotoxins; D011749:Pyrogens