[Effect of virazole on the antiviral activity of poly(G) X poly(C) and other polyribonucleotide interferonogens].
The effect of virazole on the antiviral activity of poly (G) X poly (C), poly (G, A) X X poly (C) and poly(G, I) X poly (C) was studied in cell cultures and on mice. It was shown that virazole in concentrations not sufficient for significant inhibition of the development of vesicular stomatitis virus or Sindbis virus in chick embryo cell cultures markedly increased the antiviral effect and allowed decreasing the minimum effective doses of the synthetic polyribonucleotide complexes with respect to the above viruses. Combined administration of poly (G) X poly (C) and virazole to mice 1-2 or 24 hours after infection with tick-borne encephalitis virus provided a much more pronounced decrease in the death rate of the animals than the use of the interferonogen alone. Virazole per se was little active and had no significant effect on the intensity of interferonogenesis promoted by the use of poly (G) X poly (C). A possibility of successful therapy of viral infections with polyribonucleotide interferonogens in combination with virazole or other chemotherapeutic drugs with broad antiviral spectrum is discussed.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy; D007369:Interferon Inducers / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D011066:Poly C / Q000494:pharmacology* / Q000627:therapeutic use; D011068:Poly G / Q000494:pharmacology* / Q000627:therapeutic use; D011070:Poly I-C / Q000494:pharmacology / Q000627:therapeutic use; D011131:Polyribonucleotides / Q000494:pharmacology* / Q000627:therapeutic use; D012254:Ribavirin / Q000494:pharmacology* / Q000627:therapeutic use; D012263:Ribonucleosides / Q000494:pharmacology*; D012845:Sindbis Virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014776:Virus Cultivation
D000998:Antiviral Agents; D007369:Interferon Inducers; D011131:Polyribonucleotides; D012263:Ribonucleosides; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; C036573:poly(G,I).poly(C); D012254:Ribavirin; C042481:poly(G,A).poly(C); D011070:Poly I-C
Vliianie virazola na protivovirusnuiu aktivnost' poli(G) X poli(Ts) i drugikh poliribonukleotidnykh interferonogenov.