Effect of ACE-Inhibition on regional blood flow during acute left ventricular failure in the dog. Preliminary report.
Acute left ventricular failure was induced in 7 anaesthetized dogs by embolization of the left coronary circulation with 57 micron plastic microspheres. The dogs were then subjected to ACE-inhibition with enalapril. In addition to hemodynamic measurements, tissue blood flow was measured with the radioactive microsphere method. Preliminary results are presented, showing the vasodilatory effects of enalapril to be greatest in stomach, muscle and brain while possibly compromising the renal circulation.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology; D004285:Dogs; D004656:Enalapril; D006333:Heart Failure / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; D004656:Enalapril