Adenosine A2 receptors on human monocytes modulate C2 production.
Adenosine inhibits C2 production by human monocytes. The use of synthetic analogues of adenosine suggested that the action was mediated by receptors of A2 type. EHNA which inhibits the enzyme adenosine deaminase and increases the concentration of intracellular adenosine also reduces C2 production. It is therefore possible that endogenous adenosine regulates C2 synthesis.
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000227:Adenine Nucleotides / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology*; D019830:Adenosine-5'-(N-ethylcarboxamide); D003175:Complement C2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D000242:Cyclic AMP / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000097:blood*; D011983:Receptors, Purinergic; D014372:Tubercidin / Q000494:pharmacology
D000227:Adenine Nucleotides; D003175:Complement C2; D007166:Immunosuppressive Agents; D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; C018258:3-deazaadenosine; D010660:Phenylisopropyladenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); C010192:9-(2-hydroxy-3-nonyl)adenine; D000242:Cyclic AMP; D000225:Adenine; D000241:Adenosine; D014372:Tubercidin