Changes in acetoacetate/beta-hydroxybutyrate ratio in arterial blood following hepatic artery embolization in man.
Acetoacetate/beta-hydroxybutyrate ratio in the hepatic venous blood was compared to the ratios in arterial blood and peripheral venous blood in hypoxic state following right hepatic artery embolization in 5 patients with liver cancer. Ketone body ratios in right hepatic venous blood were positively correlated with those in arterial blood (r = 0.960, p less than 0.001), but not with those in peripheral venous blood. The free NAD+/NADH ratio of the liver mitochondria, which is reflected by the ketone body ration in hepatic venous blood, can be evaluated by the ketone body ratio in the arterial blood.
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000097:blood*; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D004621:Embolization, Therapeutic; D005260:Female; D006499:Hepatic Artery; D006503:Hepatic Veins; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood*; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009243:NAD / Q000032:analysis; D013997:Time Factors
D000090:Acetoacetates; D006885:Hydroxybutyrates; D009243:NAD; C016635:acetoacetic acid; D020155:3-Hydroxybutyric Acid