Enhancement of the immune response to sheep erythrocytes in mice by phosphodiesterase-inhibiting dipyridamole derivatives.
Some potent phosphodiesterase (PDE)-inhibiting dipyridamole derivatives are able to increase the primary immune response in mice immunized with sheep red blood cells (SRBC). 10mg/kg/day of the most potent substance administered in the drinking water increased the number of plaque forming cells (PFC) in spleens of these mice by a factor of about 2 when the treatment was started after immunization. Pretreating the animals did not result in an enhancement of numbers of plaque forming cells. There was no increase in the background number of PFC.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D004176:Dipyridamole / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009012:Mopidamol / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D012756:Sheep; D013154:Spleen / Q000187:drug effects / Q000276:immunology*
D007075:Immunoglobulin M; D011743:Pyrimidines; D009012:Mopidamol; D004176:Dipyridamole; C035537:RX-RA 69; C042278:RX-RA 85; D015105:3',5'-Cyclic-AMP Phosphodiesterases