[Limited controlled trial of the reactogenic properties of ADTP vaccines containing stab cultures as the pertussis component].
The reactogenic properties of adsorbed DPT vaccine containing Bordetella pertussis cultures, grown by submerged cultivation, as the pertussis component were studied. The study revealed that the vaccine was low-reactogenic: no severe postvaccinal reactions were recorded in immunized children. The frequency and intensity of febrile and local reactions in children immunized with adsorbed DPT vaccine under trial and the commercial preparation commonly used in the USSR were identical, but considerably less pronounced than in children immunized with foreign vaccines having similar composition.
D000327:Adsorption; D001831:Body Temperature / Q000187:drug effects; D001886:Bordetella pertussis / Q000276:immunology*; D002986:Clinical Trials as Topic; D004168:Diphtheria Toxoid / Q000009:adverse effects / Q000276:immunology*; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D006940:Hyperemia / Q000453:epidemiology / Q000209:etiology; D007223:Infant; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology*; D013745:Tetanus Toxoid / Q000009:adverse effects / Q000276:immunology*; D013997:Time Factors
D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid
Izuchenie v usloviiakh ogranichennogo kontroliruemogo opyta reaktogennykh svoĭstv AKDS-vaktsin, soderzhashchikh v kachestve kokliushnogo komponenta glubinnye kul'tury.