[Molecular physiology of adrenoreceptors].
The paper reviews some problems of theoretical investigation of the spatial of adrenergic drugs and their receptors, citing results recently obtained by the authors. It includes the chapters as follows: Introduction; Conformation - activity relationships of ligands; Theoretical conformational analysis; Noradrenaline; Classification and some models of adrenergic receptors; Problems of ligands productive conformation selection and the description of receptor topography; Principles of choice of ligands; Criteria for productive conformation selection; Productive conformations of beta 2-adrenergic agonists and beta 2-receptor topography; Productive conformations of alpha 1-adrenergic receptor ligands and alpha 1-receptor topography; Structure-activity relationships of some ligands in the light of adrenergic beta 2- and alpha 1-receptors topography; Possible role of calcium ion in the interaction of adrenergic agonists with receptors.
D000818:Animals; D001665:Binding Sites; D055592:Biophysical Phenomena; D001703:Biophysics; D002118:Calcium / Q000502:physiology; D003201:Computers; D004347:Drug Interactions; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009638:Norepinephrine / Q000502:physiology; D011941:Receptors, Adrenergic / Q000145:classification / Q000502:physiology* / Q000648:ultrastructure; D011942:Receptors, Adrenergic, alpha / Q000145:classification / Q000502:physiology / Q000648:ultrastructure; D011943:Receptors, Adrenergic, beta / Q000145:classification / Q000502:physiology / Q000648:ultrastructure; D013329:Structure-Activity Relationship; D013566:Sympathomimetics / Q000494:pharmacology
D008024:Ligands; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D013566:Sympathomimetics; D002118:Calcium; D009638:Norepinephrine
K molekuliarnoĭ fiziologii adrenoretseptorov.