title: [Nucleic acid metabolism in rat liver after single and prolonged exposure to tritium oxide].
abstract: It was shown that after a single administration of tritium oxide in a dose of 22.2 MBq/g body mass the liver mass increased, the concentration of nucleic acids decreased and the biosynthesis rate increased during a one-month observation. By the end of the observation period (the first year) the parameters under study were normalized. The long-term administration of tritium oxide in daily doses of 0.37, 0.925 and 1.85 MBq/g body mass caused changes in the nucleic acid metabolism which were less manifest (at early times), than in the case of a single injection. At the same time, the long-term administration of tritium oxide in the dose of 0.925 MBq/g caused a substantial disturbance of the nucleic acid metabolism at later times (after 2-9 months).
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004247:DNA / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D012313:RNA / Q000378:metabolism*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014316:Tritium / Q000008:administration & dosage*; D014867:Water / Q000008:administration & dosage*
chemical_list: D014867:Water; D014316:Tritium; C033961:tritium oxide; D012313:RNA; D004247:DNA
vernacular_title: Metabolizm nukleinovykh kislot v pecheni krys posle odnokratnogo i dlitel'nogo vozdeĭstviia okisi tritiia.