The effect of tonsillar T cell subpopulations in antigen-specific lymphocyte proliferative response. Evidence of T cell suppression.
The presence of specific T cell subsets in tonsils, during in vitro generation of peripheral blood lymphocyte proliferative response was investigated. Tonsil T cells were selected for their activity with the monoclonal antibodies OKT4 and OKT8. The suppressor cell assay revealed the effects of tonsillar T cell subpopulations identified as OKT4- and OKT8-. The OKT8- had no inhibitory effects on proliferation of peripheral lymphocytes by Dermatophagoides farinae antigen in vitro.
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000276:immunology; D002908:Chronic Disease; D000939:Epitopes; D006801:Humans; D008213:Lymphocyte Activation; D014066:Palatine Tonsil / Q000166:cytology / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000150:complications* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014069:Tonsillitis / Q000150:complications / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000939:Epitopes