Fibrinolytic activators and inhibitors in terminal renal insufficiency and in anephric patients.
Fibrinolytic factors were measured before and after DDAVP-infusion in 18 patients on chronic, regular haemodialysis, 11 of whom underwent bilateral nephrectomy, and in 7 patients in whom non-functioning kidneys were still present. Baseline fibrinolytic activity was normal or high in all but two cases. Before haemodialysis, the response to DDAVP-infusion was greatly reduced in the majority of patients as compared with healthy controls, irrespective of the baseline level. This was in accordance with mean t-PA-antigen levels which increased only slightly after DDAVP. When DDAVP was given after haemodialysis, previous non-responders showed a normal increase in fibrinolytic activity. The level of free t-PA-inhibitors was normal in most cases as were levels of alpha 2-antiplasmin and alpha 2-macroglobulin.
D000941:Antigens / Q000032:analysis; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005342:Fibrinolysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D009392:Nephrectomy; D010960:Plasminogen Activators / Q000097:blood; D006435:Renal Dialysis; D000979:alpha-2-Antiplasmin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism; D014841:von Willebrand Factor
D000941:Antigens; D000979:alpha-2-Antiplasmin; D000511:alpha-Macroglobulins; D014841:von Willebrand Factor; D005169:Factor VIII; D010960:Plasminogen Activators; D003894:Deamino Arginine Vasopressin