Efficiency of the first component of complement (C'1) in the hemolytic reaction.
With the use of the first component of guinea pig complement (C'1) labeled in vivo with (14)C-amino acids, we have obtained evidence that, under the conditions required for the assay of C'1, each molecule of C'1 capable of interaction with cell surface antigen-antibody complexes is capable of initiating the reaction sequence that leads to lysis of the cell.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001665:Binding Sites; D002247:Carbon Isotopes; D002499:Centrifugation, Density Gradient; D003165:Complement System Proteins; D006168:Guinea Pigs; D006461:Hemolysis; D006801:Humans; D013053:Spectrophotometry
D002247:Carbon Isotopes; D003165:Complement System Proteins