[In vitro aggregation of rat platelets by cumulative doses of trypsin: influence of aprotinin].
As opposed to unique doses on different samples, cumulative doses of trypsin on the same rat platelet sample induced a monophasic and a more intense aggregation. Cumulative doses of trypsin were added in the presence of aprotinin, a protease inhibitor, and the curves drawn taking into account the amount of trypsin inhibited. In these conditions, the decrease of the maximum effect (Emax.) of trypsin, without change of the concentration inducing 50% of this maximum effect (EC50), suggests a non-competitive antagonism of trypsin by aprotinin on the mechanisms inducing platelet aggregation.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000494:pharmacology*
D007611:Aprotinin; D014357:Trypsin
Agrégation in vitro des plaquettes de Rat par doses cumulées de trypsine: influence de l'aprotinine.