Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing.
A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005796:Genes; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009424:Nervous System Physiological Phenomena; D010455:Peptides / Q000235:genetics*; D011498:Protein Precursors / Q000235:genetics*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics; D013373:Substance P / Q000235:genetics*; D015320:Tachykinins; D014018:Tissue Distribution
D009419:Nerve Tissue Proteins; D010455:Peptides; D011498:Protein Precursors; D012333:RNA, Messenger; D015320:Tachykinins; C044206:preprotachykinin; D013373:Substance P