title: On the contamination of commercially available aprotinins with pancreatic islet peptides.
abstract: Contamination of aprotinins with immunoreactive insulin, glicentin, glucagon, somatostatin, pancreatic polypeptide and pancreatic polypeptide-icosapeptide was estimated by radioimmunoassay. High somatostatin concentrations were found in two commercial preparations. Influence of somatostatin contamination of aprotinins on the clinical as well as the laboratory applications of aprotinin may thus be anticipated.
mesh_terms: D007611:Aprotinin / Q000032:analysis*; D004340:Drug Contamination; D005934:Glucagon / Q000032:analysis; D007328:Insulin / Q000032:analysis; D010187:Pancreatic Hormones / Q000032:analysis*; D010191:Pancreatic Polypeptide / Q000032:analysis; D052336:Proglucagon; D011498:Protein Precursors / Q000032:analysis; D011863:Radioimmunoassay; D013004:Somatostatin / Q000032:analysis; D013678:Technology, Pharmaceutical
chemical_list: D007328:Insulin; D010187:Pancreatic Hormones; D011498:Protein Precursors; D013004:Somatostatin; D052336:Proglucagon; D010191:Pancreatic Polypeptide; D005934:Glucagon; D007611:Aprotinin