[Dopamine and the chemoregulation of ventilation in the rat].
In pentobarbitalized rats, exogenous dopamine inhibits ventilation by acting on peripheral chemoreceptors. This inhibition is suppressed by haloperidol and by domperidone. Almitrine bismesilate, a potent glomic stimulant, potentiates dopaminergic inhibitory responses by depletion of dopamine endogenous stores. After blockade by dopamine antagonists, as well as after dopamine depletion, ventilatory responses to NaCN i.v. is increased. This potentiation can be explained by the suppression of a negative feed-back control dependent on endogenous dopamine release during the glomic stimulation itself.
D015765:Almitrine; D000818:Animals; D004294:Domperidone / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D004357:Drug Synergism; D006220:Haloperidol / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology; D012119:Respiration / Q000187:drug effects*
D010879:Piperazines; D011954:Receptors, Dopamine; D004294:Domperidone; D015765:Almitrine; D006220:Haloperidol; D004298:Dopamine
Communication brève.