New poliovirus vaccines: a molecular approach.
This article summarizes recent work on the determinants of antigenicity in poliovirus type 3 and reports on experiments in progress aimed at understanding the molecular basis of attenuation in Sabin's type 3 vaccines. Ways in which this new information might be used to produce alternative, safe, inexpensive, multivalent vaccines against polio and other enteroviruses are discussed.
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D000939:Epitopes; D009154:Mutation; D009842:Oligopeptides; D017955:Poliovirus / Q000276:immunology; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral; D011487:Protein Conformation; D011817:Rabbits; D014613:Vaccines, Attenuated
D000911:Antibodies, Monoclonal; D000939:Epitopes; D009842:Oligopeptides; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral; D014613:Vaccines, Attenuated