Omeprazole, a gastric 'proton pump inhibitor': lack of effect on renal handling of electrolytes and urinary acidification.
Omeprazole has previously been shown to be a potent inhibitor of gastric acid secretion in man. In a new study, oral omeprazole 60 mg/day was given to 8 healthy male subjects for 8 days. The daily urinary electrolyte output and urine pH in response to ammonium chloride were not significantly altered. This provides further support for the specificity of its action on gastric acid secretion.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism*; D017506:H(+)-K(+)-Exchanging ATPase; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009853:Omeprazole; D014556:Urine
D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D004573:Electrolytes; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D009853:Omeprazole