Activity of cytosolic 5'-nucleotidase in regenerating rat liver after partial hepatectomy.
The specific activity of the cytosolic 5'-nucleotidase in regenerating liver increased to 175% of the control level of sham-operated animals during the 2nd and 3rd day and remained elevated most of the experimental period. The total cytosolic 5'-nucleotidase activity of the regenerating liver reached the level of control rats between 2 and 3 days after the operation. The variation pattern of the enzyme, which was distinctly different from variations of other known phosphohydrolases, was strikingly similar to that of the salvage enzyme hypoxanthine/guanine phosphoribosyltransferase.
D015720:5'-Nucleotidase; D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D006498:Hepatectomy; D007291:Inosine Monophosphate / Q000378:metabolism*; D007292:Inosine Nucleotides / Q000378:metabolism*; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008297:Male; D009708:Nucleotidases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007292:Inosine Nucleotides; D007291:Inosine Monophosphate; D007770:L-Lactate Dehydrogenase; D009708:Nucleotidases; D000135:Acid Phosphatase; D015720:5'-Nucleotidase