[Parotid duct occlusion with prolamine--sequelae of long-term administration in the animal model].
The effects of occlusion of the parotid excretory duct, after injection of a basic aminoacid solution (prolamine), were studied in 12 rabbit parotid glands one year after prolamine application. 40% of the experimental animals present the picture of an extensive abscess-forming sialadenitis both macroscopically and microscopically. The secretory parenchyma of the gland is almost completely eliminated. Remnants of the injected prolamine solution found in the duct system could possibly be responsible for the abscess formation. At the present experimental stage therapeutic application of prolamine in the human parotid gland cannot be recommended.
D000038:Abscess / Q000139:chemically induced* / Q000473:pathology; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001284:Atrophy; D003973:Diatrizoate; D004338:Drug Combinations; D005227:Fatty Acids; D008134:Long-Term Care; D010306:Parotid Gland / Q000187:drug effects* / Q000473:pathology; D011409:Propylene Glycols; D011506:Proteins / Q000633:toxicity*; D011817:Rabbits; D012466:Salivary Gland Diseases / Q000139:chemically induced*; D012793:Sialadenitis / Q000139:chemically induced* / Q000473:pathology; D015028:Zein
D004338:Drug Combinations; D005227:Fatty Acids; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D015028:Zein; C020481:alcoholic prolamine solution; D000681:Amylases
Parotisgang-Okklusion mit Prolamin--Folgen einer Langzeitapplikation im Tiermodell.