title: [Therapeutic efficacy of trimecaine in cardiac rhythm disorders and ways of improving it].
abstract: The efficacy of antiarrhythmic therapy with trimecain in 5 different regimens was studied in 87 patients, in 146 episodes of various disorders of the cardiac rhythm. On the basis of clinical and experimental (on 14 dogs with ventricular arrhythmia) studies, different schemes of trimecain treatment are compared. It was shown that combination of the intravenous and the subsequent intramuscular administration of trimecain to treat ventricular extrasystole complicating the course of acute myocardial infarction is as effective as prolonged instillation but exerts a longer action and is better tolerated by patients. Using tetrapolar chest rheography the effect of trimecain infused in the maximum single dose on the central hemodynamics and the ECG was studied in subjects without any cardiovascular pathology. It has been established that trimecain does not suppress myocardial contractility and has no hypotensive action.
mesh_terms: D000083:Acetanilides / Q000627:therapeutic use*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001281:Atrial Fibrillation / Q000188:drug therapy; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D006801:Humans; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008875:Middle Aged; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy; D014288:Trimecaine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000083:Acetanilides; D014288:Trimecaine
vernacular_title: Terapevticheskaia éffektivnost' trimekaina pri narusheniiakh serdechnogo ritma i nekotorye puti ee povysheniia.