Macrophages bind directly to Semliki Forest virus-infected cells and mediate antibody-dependent cell-mediated cytotoxicity.
Macrophages were found to bind directly to Semliki Forest virus (SFV)-infected, but not uninfected, P815 cells. In the presence of anti-H-2d or anti-BALB/c antibody, macrophages lysed SFV-infected, but not uninfected, P815 cells. It is proposed that macrophage-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) proceeds via two functionally distinguishable initial steps: (1) adhesion of effector to target cell, which may be mediated through antibody or through viral protein, as in the case of SFV-infected target cells suboptimally sensitized with antibody; (2) antibody-dependent initiation of cytolysis.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002448:Cell Adhesion; D006183:H-2 Antigens / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012672:Semliki forest virus; D014036:Togaviridae Infections / Q000276:immunology*
D006183:H-2 Antigens