Amnesic effects of small bilateral brain puncture in the mouse.
A small acute brain puncture produced retrograde amnesia in a passive avoidance learning situation in mice. If injury to the hippocampus was inflicted either immediately, 1 hour after the learning, or 1 hour before the learning, the animals showed a retention deficit; the degree of this deficit was related to the time interval. No effect of this injury was observed on retest performance when the animals were treated as long as 6 hours before or after the learning trial.
D000647:Amnesia / Q000209:etiology*; D000818:Animals; D001362:Avoidance Learning / Q000503:physiopathology*; D001522:Behavior, Animal; D001930:Brain Injuries / Q000150:complications*; D005260:Female; D006624:Hippocampus / Q000293:injuries*; D006801:Humans; D051379:Mice; D011603:Psychophysiology; D011677:Punctures