Cellular mechanisms of acid secretion.
Current ideas about the parietal cell are presented in the model shown in Figure 6; the cell is illustrated both in resting and stimulated states. The basal-lateral surface contains three major receptor classes mediated by either cyclic AMP responses or Ca2+ changes, Ca2+ channels and a Ca2+ pump, and a variety of ion transport pathways such as Na+:H+ and Cl-:HCO-3 exchange, a K+ conductance, a postulated NaKCl2 cotransport and the (Na+ + K+)ATPase. At rest, the tubulovesicles contain the (H+ + K+)ATPase. In the stimulated state, the apical (secretory canalicular) membrane contains a K+ and Cl- conductance as well as the (H+ + K+)ATPase. There is also a change in cytoskeletal arrangement associated with stimulation.
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D001693:Biological Transport, Active; D002118:Calcium / Q000502:physiology; D002463:Cell Membrane Permeability; D000242:Cyclic AMP / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D010295:Parietal Cells, Gastric / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D011949:Receptors, Cholecystokinin; D011968:Receptors, Histamine / Q000502:physiology; D011976:Receptors, Muscarinic / Q000502:physiology
D005755:Gastrins; D007473:Ion Channels; D011956:Receptors, Cell Surface; D011949:Receptors, Cholecystokinin; D011968:Receptors, Histamine; D011976:Receptors, Muscarinic; D000242:Cyclic AMP; D002118:Calcium