[Long-term effects of substance P on the higher nervous activity of primates].
The conditioned reflex, blood pressure and behavioral parameters prior to and during a single application of Substance P to unnarcotized primates were tested on four successive days, as well as of physiological saline also administered as a single application on four successive days. The evaluations were done each after 24 h from application. In a dose range from 0.25-25 micrograms/kg b.wt. the drug improved the performance of the conditioned reflex, while at 250 micrograms/kg b.wt. no improvement was ascertainable. At high doses behavioral disorders occurred. Blood pressure values showed no detectable reactions. From 25 micrograms/kg b.wt. onwards the application produced distinct immediate vegetative reactions which, however, subsided still during the 4-day procedure. At 250 micrograms/kg b. wt., the vegetative reactions became increasingly stronger. It is concluded that the individual functional circuits of the organism respond differently to Substance P. Behavioral reactions occurring 24 h after the application were not considered to be direct effects of Substance P. It is assumed that Substance P gives a push to other neuroactive systems.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005483:Flushing / Q000139:chemically induced; D006613:Higher Nervous Activity / Q000187:drug effects*; D008297:Male; D010215:Papio; D011141:Polyuria / Q000139:chemically induced; D012472:Salivation / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*; D013997:Time Factors
D013373:Substance P
Langzeitwirkung von Substanz P auf die höhere Nerventätigkeit bei Primaten.