Case report: blastomycosis causing sciatic neuritis.
A patient presented with pain in the right lower back, radiating down the right leg. Initial pelvic X-rays did not reveal any lesion. A follow up computerized tomography (CT) scan and technitium scan showed a sharply lytic lesion of the right ilium extending to the right sacroiliac joint. Open biopsy revealed a granulomatous inflammation with many budding yeast from consistent with Blastomyces dermatitidis. Subsequent culture confirmed this identification. There was no other site of fungal infection. Two courses of Amphotericin B (each to 2 g total dose) failed to eradicate this infection. The patient is now responding to Ketoconazole.
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001758:Blastomyces / Q000302:isolation & purification; D001759:Blastomycosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007085:Ilium / Q000382:microbiology / Q000473:pathology; D007654:Ketoconazole / Q000627:therapeutic use; D009443:Neuritis / Q000209:etiology* / Q000628:therapy; D012584:Sciatic Nerve
D000666:Amphotericin B; D007654:Ketoconazole