Hemoglobin inclusions in heterozygous alpha-thalassemia according to their alpha-globin genotype.
In this study we have correlated the presence/absence of rare red blood cells with HbH inclusions with the alpha-globin genotype in a group of Sardinian alpha-thalassemia carriers, whose genotype have been defined by alpha-globin gene mapping. We found that the majority of the carriers investigated, including those with the deletion of a single or two alpha-globin genes and those with non-deletion lesions, have rare blood cells with inclusions, with no significant difference in the frequency of positive finding related to the alpha-globin genotype.
D000328:Adult; D005260:Female; D005838:Genotype; D005914:Globins / Q000235:genetics; D006447:Hemoglobin H / Q000032:analysis*; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006579:Heterozygote; D006801:Humans; D002479:Inclusion Bodies / Q000032:analysis*; D008521:Mediterranean Islands; D011247:Pregnancy; D013789:Thalassemia / Q000097:blood / Q000235:genetics*
D006455:Hemoglobins, Abnormal; D005914:Globins; D006447:Hemoglobin H