Plasma cyclic AMP and cyclic GMP in childhood-onset psychoses.
Plasma cyclic AMP is a "second messenger" that may reflect levels of activity of important neurotransmitter receptors. Plasma cyclic AMP was measured in 18 patients with childhood autism, 7 patients with pervasive developmental disorder, and 12 age- and sex-matched healthy controls. Plasma cyclic AMP was significantly elevated by over 100% in both groups of patients with childhood-onset psychoses compared with controls. Plasma cyclic GMP, a nucleotide linked to different receptors, was not elevated, suggesting that the finding may be specific.
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000097:blood; D002648:Child; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000097:blood; D011618:Psychotic Disorders / Q000097:blood*; D012561:Schizophrenia, Childhood / Q000097:blood
D000242:Cyclic AMP; D006152:Cyclic GMP