Studies on the possibility of induction of anti-H-2 alloreactive cytotoxic antibodies by syngeneic immunization.
Our studies on the syngeneic immunization with normal cells did not confirm the possibility of induction of alloreactive cytotoxic antibodies in this way. We were not able to induce any antibodies after syngeneic immunizations within BALB/c and BALB/cfC3H strains of mice. Anti-H-2 cytotoxic antibodies were raised by syngeneic immunization within BALB/Mo strain of mice, but it was found that this phenomenon was due to the heterogenicity of this strain.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006183:H-2 Antigens / Q000276:immunology*; D007114:Immunization; D007518:Isoantibodies / Q000276:immunology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology
D000939:Epitopes; D006183:H-2 Antigens; D007518:Isoantibodies