Comparative effects of N,N-disubstituted dithiocarbamates and dimercaptosuccinate on mobilization of methylmercury in mice.
Diethyldithiocarbamate (DDTC) and five of its N,N-disubstituted analogs were compared with dimercaptosuccinate (DMSA) for effectiveness in mobilizing and promoting excretion of methylmercury (MeHg) following administration of a sublethal dose of MeHg labeled with Me203Hg. The previously reported effectiveness of DMSA was confirmed. Of the dithiocarbamates assessed, only di(carboxymethyl)-dithiocarbamate (DCDC) was active in mobilizing MeHg, and its activity on a molar dose basis was less than that of DMSA. The disparate structural requirements of dithiocarbamates as antagonists of MeHg and of cadmium were discussed.
D000368:Aged; D000818:Animals; D004125:Dimethyldithiocarbamate / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism; D005028:Ethylenebis(dithiocarbamates) / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D008631:Mercury Radioisotopes; D008767:Methylmercury Compounds / Q000378:metabolism*; D051379:Mice; D004113:Succimer / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013859:Thiocarbamates / Q000494:pharmacology*
D004125:Dimethyldithiocarbamate; D005028:Ethylenebis(dithiocarbamates); D008631:Mercury Radioisotopes; D008767:Methylmercury Compounds; D013438:Sulfhydryl Compounds; D013859:Thiocarbamates; D004050:Ditiocarb; D004113:Succimer