Attempts at oral infection of rats and mice with trophozoites of Entamoeba histolytica.
Groups of athymic rnu rats were found to be susceptible to SAW 408 Entamoeba histolytica introduced intra-intestinally. The same strain of rat could be infected orally with cultured trophozoites using a gastric secretion inhibitor, cimetidine, as a pretreatment. Groups of Lac:P and Wistar rats similarly treated were also found to be susceptible although the parasite population growth was slow. A similar regimen attempted on susceptible mice was unsuccessful.
D000562:Amebiasis / Q000469:parasitology*; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D004748:Entamoeba histolytica; D004749:Entamoebiasis / Q000469:parasitology*; D007422:Intestines / Q000469:parasitology; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000002:abnormalities
D002927:Cimetidine