title: [Serum nucleases as nonspecific antiviral factors and their role in artificial anti-influenza immunity].
abstract: Experimentally, by stimulation of the activity of serum DNase and RNase direct evidence of their nonspecific protective role in herpes and influenza infections, respectively was obtained. Potentiation of the protective effect upon interaction of endogenous and exogenous nucleases with specific antibodies was demonstrated. Experiments in mice and observations in humans established a marked inhibition of serum RNase activity due to binding with the inhibitor, in mild and severe forms of influenza in nonimmune hosts and host immunized with live and inactivated vaccines. This is assumed to be one of the causes of insufficient effectiveness of artificial immunity against influenza.
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000293:Adolescent; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D003851:Deoxyribonucleases / Q000276:immunology*; D006561:Herpes Simplex / Q000201:enzymology / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology; D007251:Influenza, Human / Q000201:enzymology / Q000276:immunology*; D007372:Interferons / Q000032:analysis; D051379:Mice; D010862:Pilocarpine / Q000627:therapeutic use; D011817:Rabbits; D012260:Ribonucleases / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology; D012899:Smallpox / Q000201:enzymology / Q000276:immunology; D012901:Variola virus / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D010862:Pilocarpine; D007372:Interferons; D003851:Deoxyribonucleases; D012260:Ribonucleases
vernacular_title: Syvorotochnye nukleazy kak nespetsificheskie protivovirusnye faktory i ikh rol' v iskusstvennom protivogrippoznom immunitete.