title: Human chorionic gonadotropin and steroid concentrations in human follicular fluid in relation to follicle size and oocyte maturity in stimulated ovarian cycles.
abstract: The concentrations in follicular fluid (FF) of beta hCG, progesterone (P), estradiol (E2), androstenedione (A) and testosterone (T) by RIA were determined, in order to study the follicular micro-environment in stimulated cycles. Patients received either clomiphene with hMG plus hCG or hMG plus hCG. With increasing volume of FF (obtained at laparoscopy), P significantly increased (p less than 0.04) and hCG (p less than 0.0004) and T (p less than 0.05) significantly decreased with a borderline decrease in A (p less than 0.07). Progesterone also increased with advancing oocyte maturity. Beta-hCG and P were positively correlated with E2 and negatively correlated with A levels. It is suggested that FF hCG and progesterone levels may be markers of follicular development in stimulated cycles.
mesh_terms: D000735:Androstenedione / Q000032:analysis*; D001826:Body Fluids / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis* / Q000627:therapeutic use; D018997:Chorionic Gonadotropin, beta Subunit, Human; D002996:Clomiphene / Q000627:therapeutic use; D004958:Estradiol / Q000032:analysis*; D005260:Female; D005498:Follicular Phase; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D009865:Oocytes / Q000254:growth & development*; D006080:Ovarian Follicle / Q000032:analysis*; D010062:Ovulation Induction; D010446:Peptide Fragments / Q000032:analysis*; D011374:Progesterone / Q000032:analysis*; D011863:Radioimmunoassay; D013739:Testosterone / Q000032:analysis*
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D002996:Clomiphene; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins