Increased release of cyclic adenosine monophosphate into jugular vein in response to isoproterenol administration.
Catecholamine administration elevates plasma cyclic AMP (cAMP) levels but the source of the cAMP is unknown. To determine possible sources, plasma cAMP levels were determined in blood vessels across the head, liver, kidney and lung in anesthetized dogs infused with the beta-adrenergic agonist, isoproterenol. Only the head showed an increased release of cAMP into the blood. The kidneys removed cAMP from the blood while liver and lung showed no change. This in vivo demonstration of release of cAMP from the head represents contributions from brain and facial muscles and may be a useful approach to study brain involvement in the action of various hormones and drugs.
D000818:Animals; D002339:Carotid Arteries; D002560:Cerebrovascular Circulation; D000242:Cyclic AMP / Q000097:blood*; D004285:Dogs; D007545:Isoproterenol / Q000494:pharmacology*; D007601:Jugular Veins; D008102:Liver Circulation; D011652:Pulmonary Circulation; D012079:Renal Circulation; D013997:Time Factors
D000242:Cyclic AMP; D007545:Isoproterenol