Pharmacological studies on lymphocytes: 2. Effects of indole derivatives and their antagonists on the lymphocyte migration.
The influence of serotonin (5-HT) probably released in reactions of delayed-type hypersensitivity (DTH) on the locomotion of lymphocytes was investigated. 5-HT has a chemokinetic and a chemotactic action on the movement of enriched T-lymphocytes. This 5-HT activity is inhibited by 5-HT antagonists as 2-bromolysergic acid diethylamide, methysergide and pizotiphen. The metabolic product of 5-HT the 5-hydroxyindoleacetic acid has the same activity as 5-HT itself, whereas 5-hydroxytryptophan is without significant influence on the lymphocyte migration. Thus it is supposed that the action of 5-HT on the lymphocyte movement is a specific effect. Lymphocytes are also chemokinetically stimulated by the mediators of the DTH, the lymphokines. 5-HT and lymphokines given together lead to an additive effect. The physiological importance of the described results have to be evidenced for in vivo conditions.
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000494:pharmacology; D007211:Indoles / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008222:Lymphokines / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007211:Indoles; D008222:Lymphokines; D006897:Hydroxyindoleacetic Acid; D008238:Lysergic Acid Diethylamide; D008784:Methysergide; D004837:Epinephrine