In vitro infectivity of irradiated Plasmodium berghei sporozoites to cultured hepatoma cells.
The invasion of gamma-irradiated Plasmodium berghei sporozoites into cultured hepatoma cells and their transformation into trophozoites was similar to invasion and transformation of non-irradiated sporozoites. However, trophozoites from irradiated sporozoites did not further develop into schizonts, but persisted within the cells for up to 3 days. Sporozoite surface protective antigen was present in trophozoites from irradiated and non-irradiated sporozoites, suggesting that hepatocyte antigen processing may contribute to the induction of anti-malarial immunity.
D000818:Animals; D000941:Antigens / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000469:parasitology*; D002460:Cell Line; D005720:Gamma Rays; D006801:Humans; D008113:Liver Neoplasms; D010962:Plasmodium berghei / Q000254:growth & development* / Q000276:immunology / Q000528:radiation effects; D013997:Time Factors
D000941:Antigens