The response of the isolated iris sphincter muscle of various mammalian species to substance P.
Contractile responses of the isolated iris sphincter muscle from the rabbit, cow, pig, cat, dog, baboon and man to substance P were compared under isotonic conditions using carbachol as a reference standard. Iris preparations from the rabbit, pig and cow showed strong and consistent responses to substance P whilst those from the cat, dog, baboon and human eyes did not contract.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002415:Cats; D002417:Cattle; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007498:Iris / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D010215:Papio; D011817:Rabbits; D013373:Substance P / Q000494:pharmacology*; D013552:Swine; D014021:Tissue Preservation
D013373:Substance P; D002217:Carbachol