title: The genes coding for A alpha-, B beta-, and gamma-chains of fibrinogen map to 4q2.
abstract: We used cloned cDNA probes for the A alpha-, B beta-, and gamma-chains of human fibrinogen and Southern blotting techniques to analyze DNA from a series of rodent X human somatic cell hybrids for the presence of specific fibrinogen-related sequences. Our results provide evidence for the assignment of the three genes for fibrinogen to chromosome 4. Moreover, by direct gene-dosage determination in two patients with chromosome 4 unbalanced rearrangements, we refined the regional chromosomal assignment to 4q2, thus suggesting that these three genes whose expression is coordinately regulated are closely linked.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002905:Chromosomes, Human, 4-5; D003001:Cloning, Molecular; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII; D005340:Fibrinogen / Q000235:genetics*; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers; D005340:Fibrinogen; D004247:DNA; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII