IgM of mice infected with Mycobacterium bovis interacts selectively with T cells.
In the course of experimental BCG infection in mice, cytotoxic autoantibodies (CAA) of IgM class reacting with thymocytes and T lymphocytes were found. CAA were not cytotoxic for bone marrow cells and B lymphocytes. CAA reacts with PNA+, glass wool-adherent, hydrocortisone-sensitive thymocytes. The reaction of thymocytes with CAA and complement, prevented suppressor cell induction from such treated cells. The importance of CAA in mycobacterial infection is discussed.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D003208:Concanavalin A; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D007075:Immunoglobulin M / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012376:Rodent Diseases / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000662:veterinary*
D001323:Autoantibodies; D000939:Epitopes; D007075:Immunoglobulin M; D003208:Concanavalin A