title: The contact phase of blood coagulation in diabetes mellitus and in patients with vasculopathy.
abstract: The contact phase has been studied in diabetics and patients with macroangiopathy. Factor XII and high molecular weight kininogen (HMWK) are normal. C1-inhibitor and also alpha 2-macroglobulin are significantly elevated in diabetics with complications, for alpha 2-macroglobulin especially in patients with nephropathy, 137.5% +/- 36.0 (p less than 0.001). C1-inhibitor is also increased in vasculopathy without diabetes 113.2 +/- 22.1 (p less than 0.01). Prekallikrein (PK) is increased in all patients' groups (Table 2) as compared to normals. PK is particularly high (134% +/- 32) in 5 diabetics without macroangiopathy but with sensomotor neuropathy. This difference is remarkable because of the older age of diabetics and the negative correlation of PK with age in normals.
mesh_terms: D001777:Blood Coagulation; D003174:Complement C1 Inactivator Proteins / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood; D003929:Diabetic Neuropathies / Q000097:blood; D006487:Hemostasis; D006801:Humans; D011288:Prekallikrein / Q000032:analysis; D014652:Vascular Diseases / Q000097:blood*; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D003174:Complement C1 Inactivator Proteins; D000511:alpha-Macroglobulins; D011288:Prekallikrein