[Experimental study of the effects of cyaninoside chloride on collagen, and its potential value in ophthalmology].
Cyaninoside chloride is a drug used in the treatment of visual functional troubles in low-luminance conditions, in patients suffering from myopia and night blindness. Its effects on the enzymatic degradation of collagen by collagenase have been studied by means of two experimental models: collagen-collagenase diffusion plates, in vitro, permeabilization of the blood-brain barrier by collagenase, in rats, in vivo. The results obtained point out that cyaninosides chloride protects the collagen against the enzymatic attack due to collagenase. In the light of these results, it is possible to propose a mechanism for the action of this drug on the external blood-retinal barrier.
D000818:Animals; D000872:Anthocyanins; D001485:Basement Membrane / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000033:anatomy & histology; D003094:Collagen / Q000378:metabolism*; D003911:Dextrans; D004058:Diffusion; D005419:Flavonoids / Q000494:pharmacology*; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives*; D005452:Fluoresceins; D008297:Male; D003012:Microbial Collagenase / Q000494:pharmacology; D008856:Microscopy, Fluorescence; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects; D012685:Sepharose
D000872:Anthocyanins; D003911:Dextrans; D005419:Flavonoids; D005452:Fluoresceins; C015219:fluorescein isothiocyanate dextran; D003094:Collagen; D012685:Sepharose; D003012:Microbial Collagenase; D016650:Fluorescein-5-isothiocyanate; C020386:keracyanin
Etude expérimentale des effets du chlorure de cyaninosides sur le collagène, intérêt potentiel en ophtalmologie.