A simple mathematical method revealing the early stage of acute leukemia in patients with cytopenias.
On the basis of findings in examinations made in 50 patients (25 with hypoplastic anaemia and 15 in the hypoplastic stage of acute leukemia) a simple mathematical method was developed for the differential diagnosis of these two diseases. The following laboratory findings were used for calculating a formula: cellularity of the bone-marrow, percentage of blast cells in the myelogram, percentage of blast cells in leukocyte concentrate, morphology of erythrocytes, presence of normoblastosis, percentage of monocytes and absolute number of neutrophils in the peripheral blood. This method allows the correct diagnosis to be made in 91% of cases with hypoplastic anaemia and in 100% of cases with acute leukemia. By using 7 laboratory findings to be obtained easily this method will enable a correct diagnosis to be made even in those situations where hitherto it was very difficult to make a differential diagnosis or where it was impossible at all.
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000097:blood* / Q000175:diagnosis; D001854:Bone Marrow Cells; D003937:Diagnosis, Differential; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000175:diagnosis; D007958:Leukocyte Count; D010198:Pancytopenia / Q000097:blood* / Q000175:diagnosis; D011289:Preleukemia / Q000097:blood* / Q000175:diagnosis