[Experimental studies of the liberation of plasminogen activator by DDAVP].
Infusion of 0,4 micrograms DDAVP/kg for 30 min increased the plasminogen activator activity in blood of experimental animals (dog, rat, rabbit). The plasminogen activator releasing effect was also demonstrated in isolated perfused vascular preparations (pig ear, rat lung) at low doses (10(-9) - 10(6) mol/l). According to these results DDAVP is believed to attack directly the endothelial cell.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004431:Ear, External / Q000098:blood supply; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D008297:Male; D010477:Perfusion; D010960:Plasminogen Activators / Q000378:metabolism*; D011652:Pulmonary Circulation / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
D001127:Arginine Vasopressin; D010960:Plasminogen Activators; D003894:Deamino Arginine Vasopressin
Experimentelle Untersuchungen zur Freisetzung von Plasminogenaktivator durch DDAVP.