Chronic atropine treatment causes increase in VIP receptors in rat cerebral cortex.
Chronic atropine treatment (14 days, 20 mg X day-1 X kg-1 SC) caused a 75% increase in the number of VIP receptors in the rat cerebral cortex. The affinity of these receptors for 125I-VIP was not altered significantly by the atropine treatment. The same treatment led to a 20% decrease in VIP tissue levels. Muscarinic receptor number was also increased by 26%. The results indicate that interactions between VIP- and muscarinic receptors may be of importance in the rat cerebral cortex.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism; D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D011956:Receptors, Cell Surface; D011976:Receptors, Muscarinic; D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide; D001285:Atropine