Response to opioids in three patients with restless legs syndrome.
Three patients with restless legs syndrome, two of whom also had nocturnal myoclonus, responded well to treatment with low doses of opioids. The pathophysiology of the syndrome and the mechanism of opioids' therapeutic action are discussed.
D003061:Codeine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009207:Myoclonus / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D010098:Oxycodone / Q000494:pharmacology / Q000627:therapeutic use*; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D012148:Restless Legs Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012890:Sleep / Q000502:physiology; D012893:Sleep Wake Disorders / Q000150:complications / Q000503:physiopathology
D011957:Receptors, Opioid; D010098:Oxycodone; D008691:Methadone; D003061:Codeine