Drug synergism or antagonism in the induction of diploid meiotic products in Saccharomyces cerevisiae.
The induction of yeast diploid meiotic products by treatment with bleomycin and mitomycin C is reduced when sporulating cells are treated in combination with propranolol, and increased when they are treated in combination with caffeine. We show that bleomycin and mitomycin C act by blocking the second meiotic division. The frequency of this event appears to be directly related to the intracellular cAMP concentration which is known to be influenced in opposite ways by caffeine and propranolol.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D004336:Drug Antagonism; D004357:Drug Synergism; D008540:Meiosis / Q000187:drug effects*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects* / Q000235:genetics
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D001761:Bleomycin; D002110:Caffeine; D016685:Mitomycin; D011433:Propranolol