An in vitro technique for testing nasal vasodilating agents.
An in vitro method for testing vasoactive drugs on nasal blood vessels is described. Isolated dog nasal mucosa contracts when treated with nasal decongestant or stimulated electrically. Vasodilating drugs inhibit this contraction. Atropine blocks the effects of acetylcholine on this tissue.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001808:Blood Vessels / Q000187:drug effects*; D004285:Dogs; D004558:Electric Stimulation; D006145:Guanethidine / Q000494:pharmacology; D066298:In Vitro Techniques; D014663:Nasal Decongestants / Q000494:pharmacology; D009297:Nasal Mucosa / Q000098:blood supply*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D014663:Nasal Decongestants; D014665:Vasodilator Agents; D001285:Atropine; D000109:Acetylcholine; D006145:Guanethidine