Antibodies to intermediate filament proteins in the diagnosis and classification of human tumors.
Immunohistochemistry of intermediate filaments (IF) is a new and important way to evaluate the epithelial, mesenchymal, muscular, glial, or neural differentiation in tumors. This is based on the stable cell-type-specific expression of IF proteins in normal and neoplastic tissues. Immunohistochemical studies with antibodies to intermediate filaments have also given new perspectives in the histogenesis and biologic nature of many tumors. This article reviews both the recent findings and the authors' experience in the use of intermediate filament antibodies in tumor diagnosis and classification.
D000230:Adenocarcinoma / Q000175:diagnosis; D000912:Antibodies, Neoplasm / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003893:Desmin / Q000276:immunology; D003937:Diagnosis, Differential; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D007633:Keratins / Q000276:immunology; D008545:Melanoma / Q000175:diagnosis; D008654:Mesothelioma / Q000175:diagnosis; D008840:Microfilament Proteins / Q000276:immunology*; D008854:Microscopy, Electron; D009363:Neoplasm Proteins / Q000276:immunology*; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis*; D009423:Nervous System Neoplasms / Q000175:diagnosis; D012509:Sarcoma / Q000175:diagnosis; D012983:Soft Tissue Neoplasms / Q000175:diagnosis; D013964:Thyroid Neoplasms / Q000175:diagnosis; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis; D014746:Vimentin / Q000276:immunology
D000912:Antibodies, Neoplasm; D003893:Desmin; D005904:Glial Fibrillary Acidic Protein; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; D014746:Vimentin; D007633:Keratins