Effect of tunicamycin on human rotavirus morphogenesis and infectivity. Brief report.
In the presence of tunicamycin, decreases in the number of double-shelled human rotavirus particles coincided with a reduction in cell lysates infectivity. The majority of particles within the endoplasmic reticulum were membrane bound, "enveloped" particles.
D000818:Animals; D002478:Cells, Cultured; D005944:Glucosamine / Q000031:analogs & derivatives*; D008253:Macaca mulatta; D009024:Morphogenesis / Q000187:drug effects*; D012401:Rotavirus / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D014415:Tunicamycin / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis
D014764:Viral Proteins; D014415:Tunicamycin; D005944:Glucosamine