So-called glandular schwannoma: ependymal differentiation in a case.
A cervical root tumor in a patient with neurofibromatosis showed a biphasic pattern of spindle and epitheloid cells with prominent "gland" formation, characteristic of the so-called glandular schwannoma. Electron microscopy and histochemistry of the "glands" disclosed features consistent with an ependymal differentiation. It is noted that there is a curious preferential association of ependymal lesions and neurofibromatosis, the pathogenesis of which is not understood.
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure*; D004805:Ependyma / Q000648:ultrastructure*; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D009378:Neoplasms, Multiple Primary / Q000648:ultrastructure; D009442:Neurilemmoma / Q000648:ultrastructure*; D009456:Neurofibromatosis 1 / Q000648:ultrastructure; D010524:Peripheral Nervous System Neoplasms / Q000648:ultrastructure*; D013126:Spinal Nerve Roots / Q000648:ultrastructure*