1,25-Dihydroxyvitamin D3 inhibits selectively the mitogenic stimulation of mouse medullary thymocytes.
Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physiological concentrations, inhibits the mitogenic response of the medullary cells to phytohemagglutinin and interleukin-2, but has no effect on the cortical subpopulation. Other less active metabolites of vitamin D had little or no effect on medullary cell stimulation.
D000818:Animals; D010367:Arachis; D002117:Calcitriol / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D037102:Lectins; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D019887:Peanut Agglutinin; D037121:Plant Lectins; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000032:analysis; D013950:Thymus Gland / Q000276:immunology
D037102:Lectins; D019887:Peanut Agglutinin; D037121:Plant Lectins; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D002117:Calcitriol