title: [Cerebrospinal fluid diffusion kinetics of cefotaxime and fosfomycin in Staphylococcus aureus meningitis with otorrhea].
abstract: A case of post-traumatic meningitis with otorrhea due to Staphylococcus aureus was successfully treated with a cefotaxim-fosfomycin (CTX-FOS) combination. Serial samples of CSF leaking from the ear showed that maximal concentrations of CTX and FOS, 3.24 mg/l and 19.10 mg/l respectively, occurred one hour after the infusion of both antibiotics was terminated. For desacetyl-cefotaxim (D-CTX), maximal concentration (1.24 mg/l) occurred two hours later. These findings suggest that lumber puncture to control maximal penetration of CTX and FOS into CSF should be done one hour after infusion of both antibiotics.
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid*; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid*; D002558:Cerebrospinal Fluid Otorrhea / Q000134:cerebrospinal fluid / Q000150:complications; D004352:Drug Resistance, Microbial; D005578:Fosfomycin / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000150:complications; D013203:Staphylococcal Infections / Q000134:cerebrospinal fluid*
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; C029281:desacetylcefotaxime; D002439:Cefotaxime
vernacular_title: Etude de la cinétique de diffusion dans le liquide céphalo-rachidien du céfotaxime et de la fosfomycine au cours d'une méningite à staphylocoque doré avec otorrhée.