Studies of the antigenic variation in poliovirus type 1. Selection and analysis of variant strains with monoclonal antibodies by neutralization.
Nine neutralizing monoclonal antibodies were used in a preliminary study of the antigenic variation of poliovirus type 1. Six antigenic variants were selected and five distinct epitopes involved in neutralization were identified. Four of these epitopes are thought to be clustered within a single antigenic site. In kinetic studies, the neutralization of poliovirus by monoclonal antibodies was shown to be a single hit process.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D014644:Genetic Variation; D051379:Mice; D009500:Neutralization Tests; D017955:Poliovirus / Q000235:genetics / Q000276:immunology*; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes