Removal of extracellular Ca stimulates histamine release from rat mast cells by mobilizing a labile cellular source of Ca.
Rat mast cells were stimulated by simultaneous removal of external Ca and Na, and their secretory mechanism was investigated. A brief EGTA-treatment of the cells markedly diminished this response with little affection the response to compound 48/80, suggesting that mobilization of Ca from labile pools in the membrane is involved in this response.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D004533:Egtazic Acid / Q000494:pharmacology; D006636:Histamine Release; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000502:physiology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003189:p-Methoxy-N-methylphenethylamine; D004533:Egtazic Acid; D012964:Sodium; D002118:Calcium