title: Effects of prolactin, bromocriptine and sulpiride on estrogen and lactogenic receptors in the rat adrenal gland.
abstract: In prepubertal male rats, the injection of bromocriptine (Br) for 10 days caused an increase in adrenal weight (Br 0.75 mg/kg BW (Br I): 2.83%; Br 1.5 mg/kg BW (Br II): 12.1% and Br 3 mg/kg BW (Br III): 24.7%), and this effect was only significant at the highest dose. Sulpiride (S, 30 mg/kg BW/day) for 10 days produced a significant decrease in adrenal weight (18.6%), whereas ovine prolactin (oPRL) administered at doses of 0.5 or 5 mg/kg BW/day for 10 had no effect on this parameter. The action of these drugs on corticosterone serum levels was for Br III a 50.6% increase and for S a 29.2% decrease. Bromocriptine caused a significant increment of cytosolic available estrogen receptors C: 7.65 +/- 0.36 (SE); Br I: 10.2 +/- 0.36; Br II: 11.0 +/- 0.23 and Br III: 13.3 +/- 0.35) and total lactogenic receptors in the adrenal gland (C: 125.2 +/- 2.84; Br I: 203.8 +/- 4.43; Br II: 213.1 +/- 7.58 and Br III: 251.3 +/- 10.4), and this effect was dose-related. oPRL diminished adrenal estrogen receptors only at the highest dose used (C: 11.1 +/- 1.73; PRL 5: 8.2 +/- 0.75) as did S (C: 11.2 +/- 1.84 and S: 5.2 +/- 1.07); while the former originated a marked decrease in lactogenic adrenal binding sites at both doses (C: 198.7 +/- 12.2; PRL 0.5: 52.9 +/- 5.00 and PRL 5: 38.8 +/- 4.76), S also had a highly significant diminution over these receptors.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011388:Prolactin / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects; D011960:Receptors, Estrogen / Q000187:drug effects*; D011981:Receptors, Prolactin; D013469:Sulpiride / Q000494:pharmacology*
chemical_list: D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D011981:Receptors, Prolactin; D001971:Bromocriptine; D013469:Sulpiride; D011388:Prolactin; D003345:Corticosterone