title: [Immunotherapy with immunoglobulins].
abstract: Based on the recent knowledge about synergism of antibiotics and immunoglobulin preparations the intravenous immunoglobulin application becomes significant with respect to prophylaxis and therapy of severe general infections. Immunoglobulins react specifically against surface structures of foreign bodies, inactivating in this manner small germs, viruses and toxins. Granulocytes and macrophages incorporate especially particles coated with immunoglobulins. A cumulative effect of antibiotics with respect to bactericidy could be observed in cases of an additional immunoglobulin application. Preparations available in presence are demonstrated. Those obtained by proteolysis or chemical blocking of the complement activating IgG-Fc-part are used on a large scale. Using the limitated sulfitolysis the application of an immunoglobulin was possible which was of internal structure. The so-called high dose immunoglobulin administration is to be preferred in prophylactical and therapeutical indications. In some cases fresh frozen plasma can be applicated for the purpose of immunosubstitution.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003167:Complement Activation; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007116:Immunization, Passive / Q000379:methods*; D007074:Immunoglobulin G / Q000008:administration & dosage; D007136:Immunoglobulins / Q000378:metabolism; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy; D007239:Infections / Q000276:immunology / Q000628:therapy*; D008657:Metabolic Clearance Rate; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D007074:Immunoglobulin G; D007136:Immunoglobulins; D005719:gamma-Globulins
vernacular_title: Immuntherapie mit Immunglobulinen.