Effect of verapamil on interferon production, mastocyte degranulation and histamine release--studies in mice sensitized with ovalbumin.
The effect of verapamil, calcium antagonist, on the IFN production, the histamine release and degranulation of mastocytes were studied. The mastocytes were harvested from mice sensitized with ovalbumin, treated with verapamil and induced with Newcastle virus (NDV) to the interferon production (IFN). It has been shown that the percentage of degranulation was lower in mastocytes of the mice treated with verapamil, both induced with NDV and non-induced ones. The titer of interferon was lower when the mice induced with virus were injected with verapamil. The inhibitory effect of this drug on histamine release has only been found on the 8th day after the sensitization.
D000818:Animals; D002118:Calcium / Q000502:physiology; D006636:Histamine Release / Q000187:drug effects*; D007372:Interferons / Q000096:biosynthesis*; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice; D014700:Verapamil / Q000494:pharmacology*
D007372:Interferons; D014700:Verapamil; D002118:Calcium