The ciliated human keratinocyte.
Human keratinocytes were investigated for the presence of single cilia. Almost all basal keratinocytes were found to carry a single cilium in normal, occluded, and psoriatic skin. The ciliary structure was progressively reduced in keratinocytes approaching the surface. No remnants of the ciliary apparatus were found in the granular layer. In one case of nickel-allergic dermatitis (patch test), the keratinocytes had lost their cilia; the significance of this surprising finding remains to be elucidated.
D000328:Adult; D002923:Cilia / Q000648:ultrastructure; D003877:Dermatitis, Contact / Q000473:pathology; D000078404:Epidermal Cells; D004817:Epidermis / Q000648:ultrastructure*; D006801:Humans; D007633:Keratins; D008854:Microscopy, Electron; D009532:Nickel / Q000009:adverse effects; D011565:Psoriasis / Q000473:pathology
D007633:Keratins; D009532:Nickel