Decreased platelet 3H-imipramine binding sites in classical migraine.
Patients with classical migraine investigated between attacks had significantly fewer platelet 3H-imipramine binding sites than control subjects and this finding was more marked in males than in females. There was no abnormality of binding characteristics of platelet 5-hydroxytryptamine receptors or of platelet alpha 2-adrenoceptors. Because the reduced 3H-imipramine binding capacity was found in classical migraineurs who were investigated between attacks, it may reflect a predisposition to migraine rather than being a consequence of attacks.
D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood*; D007700:Kinetics; D008238:Lysergic Acid Diethylamide / Q000097:blood; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D011941:Receptors, Adrenergic / Q000378:metabolism; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D012737:Sex Factors; D015016:Yohimbine / Q000097:blood
D002352:Carrier Proteins; D011941:Receptors, Adrenergic; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; C027775:imipramine receptor; D015016:Yohimbine; D008238:Lysergic Acid Diethylamide; D007099:Imipramine