Effect of anti-inflammatory drugs on leukocyte superoxide production by soluble and particulate stimuli.
When polymorphonuclear leukocytes are treated with soluble and particulate substances the cells produce superoxide anion O2-. which plays a role in the activation of the oxidative metabolism. The time-course of O2-. release and the extent to which the anion is produced are related to the nature of the stimulating agents. Anti-inflammatory non steroid drugs, such as indomethacin and oxamethacin, exert a variable depression of the oxidative burst, which does not seem correlated to the inhibition of prostaglandin synthesis.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D004072:Digitonin / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007700:Kinetics; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013481:Superoxides / Q000097:blood*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D003208:Concanavalin A; D013481:Superoxides; C019028:oxamethacin; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015054:Zymosan; D004072:Digitonin; D013755:Tetradecanoylphorbol Acetate; D007213:Indomethacin