Inflammatory effects of otic drops on the middle ear.
Combination topical otic preparations are used to treat many infections of the external and middle ears. Despite the presence of ototoxic drugs in a number of these drops and convincing evidence of sensorineural hearing loss in humans and animal studies (Meyerhoff et al., presented at Southern Section Triological Meeting, Jan. 1983) following use of these medications, otic drops remain the cornerstone of treatment for many infectious disorders of the ear. Twelve chinchillas underwent bilateral tympanostomy tube placement and daily instillation of Cortisporin Otic Suspension (polymyxin B, neomycin, hydrocortisone, propylene glycol) in the right external auditory canal for 7 consecutive days. The animals were sacrificed 3 days later, 10 days following initiation of the Cortisporin Otic Suspension treatment. Following routine preparation of the temporal bones for light microscopy, the tissue was evaluated for evidence of inflammatory changes. All 12 animals demonstrated granulation tissue, effusion and focal hemorrhage in the ears subjected to the Cortisporin Otic Suspension. All of the contralateral control ears were normal. The present data suggest that this inflammatory response is due to a topical irritant effect of the otic preparation.
D000818:Animals; D002682:Chinchilla; D004338:Drug Combinations / Q000633:toxicity; D004429:Ear Ossicles / Q000473:pathology; D004432:Ear, Middle / Q000473:pathology; D006097:Granulation Tissue / Q000473:pathology; D006854:Hydrocortisone / Q000633:toxicity*; D009355:Neomycin / Q000633:toxicity*; D010033:Otitis Media / Q000139:chemically induced*; D010034:Otitis Media with Effusion / Q000139:chemically induced* / Q000473:pathology; D011112:Polymyxin B / Q000633:toxicity*; D011113:Polymyxins / Q000633:toxicity*
D004338:Drug Combinations; D011113:Polymyxins; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone