Actinomycin D blocks formation of memory of shock-avoidance in goldfish.
When 2 micrograms of antinomycin D was injected intracranially into goldfish immediately after a training session, the formation of long-term memory of a shock-avoidance was blocked. The results are discussed in relation to similar findings with acetoxycycloheximide and puromycin in the goldfish and with apparently conflicting results in the mouse.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003530:Cyprinidae; D003609:Dactinomycin / Q000494:pharmacology; D007267:Injections; D007930:Leucine / Q000378:metabolism; D008568:Memory / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D014316:Tritium; D003609:Dactinomycin; D012313:RNA; D007930:Leucine; D014529:Uridine