Comparative studies on primycin and gramicidin induced cation transport changes in human erythrocytes.
A comparative study of the actions of antibiotics primycin and gramicidin on tracer exchange of red blood cells at steady state salt distribution was carried out. The equilibrium radioactive ion distribution was not achieved at definite concentrations of either antibiotics. A development of Adam's statistical mechanical model for cooperative transitions in membranes are presented to explain the results obtained.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D002412:Cations; D002586:Cesium / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006096:Gramicidin / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D007783:Lactones / Q000494:pharmacology; D018942:Macrolides; D008433:Mathematics; D008954:Models, Biological; D011188:Potassium / Q000097:blood; D012413:Rubidium / Q000097:blood
D000900:Anti-Bacterial Agents; D002412:Cations; D007783:Lactones; D018942:Macrolides; D006096:Gramicidin; D002586:Cesium; C009041:primycin; D012413:Rubidium; D011188:Potassium