[Evaluation of the extravascular distribution of cefotiam (SCE 963) by the skin blister technic].
Extravascular diffusion of cefotiam was studied by a suction blister technique. Maximal cefotiam concentration in blister fluid (18.4 +/- 6.4 micrograms X ml-1) was found one hour after intravenous injection of a 1 g bolus. The area under the curve (AUC) of blister fluid concentrations was 35.4 micrograms X ml-1. Apparent elimination half-life from blister fluid was 0.72 hour. The AUC plasma/AUC blister fluid ratio approximated 1.
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000378:metabolism; D001768:Blister / Q000378:metabolism*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D015310:Cefotiam; D006207:Half-Life; D006801:Humans; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D015310:Cefotiam; D002439:Cefotaxime
Appréciation de la distribution extravasculaire du céfotiam (SCE 963) par les techniques des phlyctènes.