title: Barbiturate influence upon organization of lateral geniculate receptive fields in cats.
abstract: Under different levels of Nembutal anesthesia the spatiotemporal characteristics of receptive fields of cells in the lateral geniculate nucleus were investigated. All units decreased their maintained activity and bursts of spikes occurred spontaneously after administration of the anesthetic. The excitatory domains of the receptive fields were also changed by shortening of the cell's sustained response and enhancement of the postinhibitory transient responses; the spatial extent of these domains being less affected. A qualitatively new excitatory tertiary domain appeared in the receptive field surround with a latency of 170-300 ms. These effects together with enhancement of the spatiotemporal extent of inhibitory domains suggest that the suppressive action of barbiturate takes place beyond the retina.
mesh_terms: D000818:Animals; D002415:Cats; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005829:Geniculate Bodies / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*; D014795:Visual Pathways / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects*
chemical_list: D010424:Pentobarbital