[Protein kinase activity in proliferating Ehrlich ascites tumor cells].
It was demonstrated that the activity of cAMP-dependent histone and casein kinases is maximal at the end of the exponential phase of tumour growth, i. e., on the 8-10th day and decreases in the stationary growth phase, i. e., by the 15th day. The maximal activity of histone and casein kinases is observed in the S-phase of the cell cycle, the degree of cAMP-dependent histone kinase activation reaching its maximum. A chromatographic analysis of cytosolic protein kinases revealed a significant increase in the activity of cAMP-dependent histone kinase of the second type within the same time interval. Cell proliferation was paralleled with changes in the relative content of the two forms of casein kinases.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology* / Q000473:pathology; D047388:Casein Kinases; D002453:Cell Cycle; D002455:Cell Division; D002848:Chromatography, DEAE-Cellulose; D051379:Mice; D006656:Protamine Kinase / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*
D011494:Protein Kinases; D047388:Casein Kinases; D006656:Protamine Kinase
Aktivnost' proteinkinaz v proliferiruiushchikh kletkakh astsitnoĭ kartsinomy Erlikha.