A model for obtaining predictable natural transmission of rhinoviruses in human volunteers.
A model has been developed in which rhinoviral colds can be predictably transmitted by experimentally infected donors to susceptible recipients in a continuously monitored and controlled environment under simulated natural conditions. Rates of transmission correlated closely (r = .926, P less than .01) with donor-hours of exposure. This model can be used to define routes of transmission, to explore methods of controlling dissemination, to study resistance mechanisms, and to test preventive and therapeutic agents.
D000293:Adolescent; D000328:Adult; D003139:Common Cold / Q000382:microbiology / Q000635:transmission*; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000382:microbiology; D012229:Rhinovirus / Q000302:isolation & purification; D013997:Time Factors