[Thrombogenicity of a new prothrombin complex concentrate].
A prothrombin complex concentrate produced according to a new procedure was tested for potential thrombogenicity in vitro and in vivo. The results obtained by in vitro methods (NAPTT, TGt50, determination of the hydrolytic index) were not in the critical range of thrombogenicity. An effective dose of 175 U/kg for thrombus formation assessed in the stasis model of Wessler suggested comparatively low thrombogenicity. In the non stasis model no changes in the haemostaseological variables indicative of consumption reaction were observed after infusion of 125 U/kg for 30 min in rabbits. In the organs investigated (heart, liver, kidneys, adrenals) no thrombin were detected morphologically.
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000494:pharmacology*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D005167:Factor VII / Q000378:metabolism; D015942:Factor VIIa; D005170:Factor X / Q000378:metabolism; D005174:Factor XII / Q000378:metabolism; D015956:Factor XIIa; D015951:Factor Xa; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism; D007610:Kallikreins / Q000378:metabolism; D008297:Male; D010314:Partial Thromboplastin Time; D010446:Peptide Fragments / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism; D011817:Rabbits; D013917:Thrombin / Q000378:metabolism; D013918:Thrombin Time; D013927:Thrombosis / Q000139:chemically induced
D001779:Blood Coagulation Factors; D010446:Peptide Fragments; C025667:prothrombin complex concentrates; D000990:Antithrombin III; D005167:Factor VII; D005170:Factor X; D005174:Factor XII; D005337:Fibrin; D010958:Plasminogen; D007610:Kallikreins; D015942:Factor VIIa; D015956:Factor XIIa; D013917:Thrombin; D015951:Factor Xa; D005341:Fibrinolysin
Untersuchungen zur Thrombogenität eines neuen Prothrombinkomplexkonzentrates.