Effect of neurotensin, substance P and TRH on the regulation of dopamine receptors in rat brain.
Rats were exposed for one week to either neurotensin (4 micrograms/h), substance P (3.3 micrograms/h), thyrotropin-releasing hormone (5 micrograms/h), or saline administered intracerebroventricularly via mini osmotic-pumps and either haloperidol (2.5 mg/kg i.p., 2 X daily) or vehicle control. The peptide treatments by themselves did not alter [3H]spiroperidol binding in either the nucleus accumbens or the striatum. Neurotensin, however, augmented the increase in [3H]spiroperidol binding caused by the haloperidol treatment in both the nucleus accumbens and striatum.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013134:Spiperone / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013373:Substance P; D009496:Neurotensin; D013134:Spiperone; D013973:Thyrotropin-Releasing Hormone; D006220:Haloperidol