[Bioelectrical, biochemical and histomorphological changes in the ocular tissues in pituitrin hypertension and the use of euphylline and papaverine].
Experimental study on rabbits of bioelectric and biochemical characteristics of eye tissues during pituitrin hypertension and application of euphylline and papaverine as well as comparison of the data obtained indicate that during pituitrin hypertension, transtissue potential difference and density of short-circuit current in the lens are considerably increased whereas the level of tissue respiration in the eye is reduced. Administration of euphylline or papaverine during pituitrin hypertension aggravates hemodynamic disorders in eye tissues, deteriorates the bioelectric and biochemical characteristics in both hypertensive and control animals.
D000628:Aminophylline / Q000627:therapeutic use*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D005123:Eye / Q000187:drug effects / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D008564:Membrane Potentials / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010208:Papaverine / Q000627:therapeutic use*; D010909:Pituitary Hormones, Posterior / Q000633:toxicity*; D011817:Rabbits
D010909:Pituitary Hormones, Posterior; D000628:Aminophylline; D010208:Papaverine
Bioélektricheskie, biokhimicheskie i gistomorfologicheskie izmeneniia v tkaniakh glaza pri pituitrinovoĭ gipertenzii i primenenii éufillina i papaverina.