Splenic granulopoietic morphology in laboratory rats after experimental induction of marrow hypoplasia.
Within the granulopoietic recovery phase the proportion of neutrophils and their precursors in the spleen was elevated from 1.7 +/- 0.3% (controls) to 14.7 +/- 2.2% (on day 14 after cyclophosphamide). Splenic granulopoiesis persisted for a time after the appearance of marrow recovery. These data suggest that the rat adult spleen can become a markedly granulopoietic organ during the regeneration of granulopoiesis which follows experimentally induced myelosuppression.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity*; D004804:Eosinophils / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects; D013154:Spleen / Q000187:drug effects*
D003520:Cyclophosphamide