title: Hydromorphone effects on human conversational speech.
abstract: The present study provides an objective assessment of the increased talkativeness associated with acute opiate drug administration. Speech of five methadone-maintenance subjects was recorded continuously for 1 h following the injection of 0, 10, 14, or 18 mg hydromorphone. Dose-related increases in subjects' speech were observed, while no systematic changes were seen in speech of an undrugged partner. Dose-related increases were also obtained on an adjective checklist measuring characteristic opiate signs and symptoms. The relationship between behavioral, subjective, and reinforcing drug effects is discussed.
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D006801:Humans; D004091:Hydromorphone / Q000494:pharmacology*; D008297:Male; D013060:Speech / Q000187:drug effects*; D013997:Time Factors
chemical_list: D004091:Hydromorphone