Enhanced cerebrovascular permeability by Metrazol: significance for brain metastases.
Metrazol enhanced the penetration of two proteins (125I human serum albumin and horseradish peroxidase), and the anticancer agent, razoxane, into the central nervous system of anaesthetized rats. Penetration was increased throughout the whole brain. With the exception of the bladder, no peripheral tissue was affected. The increase in brain permeability was temporary and reversed within 4 hours; brain levels of drug and protein were increased by up to three times.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D004569:Electroencephalography; D005629:Frozen Sections; D006735:Horseradish Peroxidase / Q000378:metabolism; D007700:Kinetics; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010879:Piperazines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011929:Razoxane / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism; D013194:Staining and Labeling; D014018:Tissue Distribution
D010879:Piperazines; D012709:Serum Albumin; D011929:Razoxane; D006735:Horseradish Peroxidase; D010433:Pentylenetetrazole