[Continuous measurement of lysis of radioactively marked fibrin clots].
Methods for continuous measurement of dissolution of experimentally induced radioactively labelled thrombi were described. They are suited for the use in artificial circulating systems and in animal experiments. The radioactivity can be measured continuously in a circulating system by fitting a flow through cell with a well scintillator. In order to measure thrombotic processes in vivo, we developed a specially adapted single hole collimator. By this device changes in radioactivity over a defined occluded area of the vessel could be detected. The usefulness of the methods was demonstrated by means of a thrombolytic agent.
D000818:Animals; D001780:Blood Coagulation Tests / Q000379:methods*; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D007457:Iodine Radioisotopes; D008955:Models, Cardiovascular; D011817:Rabbits; D011877:Radionuclide Imaging; D013917:Thrombin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood / Q000000981:diagnostic imaging
D007457:Iodine Radioisotopes; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin
Kontinuierliche Messung der Lyse radioaktiv markierter Fibringerinnsel.