title: Ir gene control of T and B cell responses to determinants in (Glu Lys Ala) terpolymers.
abstract: All mice responding to the terpolymer GLA40 make GL, GA and GLA specific antibodies irrespective of their response to GL or GA alone. The mice displayed positive T cell proliferative responses against the homologous terpolymer, but no T cell responses were obtained with GL, which is non-immunogenic in mice. T cells from GLA immune mice, which are also responders to GA, such as mice of H-2 haplotypes a, b, d, k and r, could be stimulated by GA. T cells from GLA immune mice of H-2 haplotypes p and q which are non-responders to GA could not be stimulated by GA. On the other hand, T cells from H-2s mice immune to GLA and which are also responders to GA alone could not be stimulated by GA. Thus mice of H-2 haplotypes p, q and s recognize the terpolymer via 'GLA' determinants alone, whereas mice of H-2 haplotypes a, b, d, k and r may recognize both GA and GLA determinants in GLA terpolymer.
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D005802:Genes, MHC Class II; D006183:H-2 Antigens; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000276:immunology*; D011099:Polyglutamic Acid / Q000276:immunology / Q000031:analogs & derivatives; D011107:Polylysine / Q000276:immunology / Q000031:analogs & derivatives; D011108:Polymers; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000939:Epitopes; D006183:H-2 Antigens; D010455:Peptides; D011108:Polymers; D011107:Polylysine; D011099:Polyglutamic Acid; C044187:glutamic acid-lysine-alanine polymer; C030391:poly(glutamic acid-lysine); C036437:poly(glutamic acid-alanine); D000409:Alanine