Dosage of chloramphenicol in typhoid and paratyphoid in children.
Over a period of 12 years, 109 children with salmonella enteric fever were treated with chloramphenicol: 65 children were given the drug at 50 mg/kg/24 h (Group A) and 44 received 100 mg/kg/24 h (Group B). Treatment failed in 63% with the lower dose and in 24% of children treated with the higher dose (P less than 0.001). In the children who received only chloramphenicol, the higher dose produced a clinical response in 5.4 (1.8) (mean (S.D.] days compared with 7 (2.6) days with the lower dose (P less than 0.01). Chloramphenicol in an initial dose of 100 mg/kg/24 h is recommended in the treatment of typhoid and paratyphoid in children.
D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010284:Paratyphoid Fever / Q000188:drug therapy*; D012189:Retrospective Studies; D012482:Salmonella paratyphi A; D014435:Typhoid Fever / Q000188:drug therapy*
D002701:Chloramphenicol