[The detection of antibodies against D-penicillamine. 1. Coupling of D-penicillamine to various carriers and generation of antibodies against D-penicillamine conjugate].
D-Penicillamin as 2-substituted 5,5-Dimethyl-thiazolidine-4-carbonic acid has been bound to poly-L-lysin, human serum albumin and bovine gamma globulin by means of a water-soluble carbodiimid. The anti-bodies generated at animal tests by immunization of guinea pigs had been proved by means of the radial immune diffusion acc. to Ouchterlony [10].
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000917:Antibody Formation; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006801:Humans; D005779:Immunodiffusion; D010396:Penicillamine / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism
D000906:Antibodies; D012709:Serum Albumin; D005719:gamma-Globulins; D010396:Penicillamine
Zum Nachweis von Antikörpern gegen D-Penicillamin. 1. Mitteilung: Kopplung von D-Penicillamin an verschiedene Träger und Erzeugung von Antikörpern gegen D-Penicillamin-Konjugate.