title: [Biological determinants of schizophrenic psychoses].
abstract: In this article the biological factors i.e. neuropathological/structural and biochemical, involved in the pathogenesis of schizophrenia are reviewed. Particularly the endorphin hypothesis, which states that disturbances in the fragmentation of beta-endorphin are implicated in schizophrenia, is emphasized. The concept of type I and type II schizophrenia, disturbances in the serine-glycine metabolism and the neuropeptide strategy are currently under investigation.
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002395:Catecholamines / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008745:Methylation; D011011:Pneumoencephalography; D012559:Schizophrenia / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D009435:Synaptic Transmission; D014057:Tomography, X-Ray Computed
chemical_list: D002395:Catecholamines; D004723:Endorphins; D004298:Dopamine
vernacular_title: Déterminants biologiques des psychoses schizophréniques.