title: [Blood histamine level and anaphylactic reaction under alphadione].
abstract: Histamine release is generally thought to play a major role in anaesthetic-induced anaphylactoid reactions. In 12 patients who were developing such a reaction at the start of a slow rate intra-venous infusion of alphadione, serum histamine was measured using the enzyme-isotopic assay from a blood sample drawn within the first 5 minutes following the onset of clinical signs. Histaminemia above normal value was noted in 3 patients only without clear clinical correlation. These results would suggest that histamine release is unlikely to be principally involved in this kind of adverse reaction.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000009:adverse effects*; D000707:Anaphylaxis / Q000097:blood / Q000139:chemically induced*; D005260:Female; D006632:Histamine / Q000097:blood*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000530:Alfaxalone Alfadolone Mixture; D006632:Histamine
vernacular_title: Histaminémie et réactions anaphylactoïdes sous alfadione.