Evaluation of pesticides which pose carcinogenicity potential in animal testing. II. Consideration of human exposure conditions for regulatory decision making.
In reaching a regulatory decision on the use of pesticides with carcinogenic potential, it is of great importance to investigate the extent of dermal exposure and absorption of a pesticide to users and field workers. By applying this information, along with the appropriate carcinogenicity categorization of a pesticide, a reasonably sound regulatory decision can be derived. Seven pesticides were selected, based on adequacy of tumor data, and were taken through the tumor evaluation system as reported in Part I 1984, Regul. Toxicol. Pharmacol. 4, 355-360). A step-by-step analysis on how a regulatory decision is reached on each pesticide by the EPA and CDFA was discussed.
D000382:Agricultural Workers' Diseases / Q000139:chemically induced; D000498:Allyl Compounds / Q000633:toxicity; D000818:Animals; D001561:Benzilates / Q000633:toxicity; D002140:California; D002273:Carcinogens; D003657:Decision Making; D015946:Ethylene Dibromide / Q000633:toxicity; D001556:Hexachlorocyclohexane / Q000633:toxicity; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000633:toxicity; D007880:Legislation, Drug / Q000639:trends*; D009369:Neoplasms / Q000139:chemically induced; D010069:Oxadiazoles / Q000633:toxicity; D010575:Pesticides / Q000633:toxicity*; D012306:Risk; D012869:Skin Absorption; D014052:Toluidines / Q000633:toxicity; D014112:Toxaphene / Q000633:toxicity
D000498:Allyl Compounds; D001561:Benzilates; D002273:Carcinogens; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D010069:Oxadiazoles; D010575:Pesticides; D014052:Toluidines; D015946:Ethylene Dibromide; C014983:amitraz; D001556:Hexachlorocyclohexane; D014112:Toxaphene; C023891:1,3-dichloro-1-propene; C012466:oxadiazon; C004659:chlorobenzilate