New antibacterial agent (U-24,544) isolated from Streptomyces griseus.
Antibiotic U-24,544 is a new agent isolated from the culture broth of a streptomycete strain. The antibiotic inhibits a variety of gram-positive and gram-negative bacteria in vitro, but is ineffective in treatment of experimental bacterial infections in mice. It is fairly cytotoxic in mammalian cell cultures and remarkably nontoxic in mice.
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D013053:Spectrophotometry; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents