Plasma beta-endorphin levels in oral surgery patients following diazepam, fentanyl or placebo.
Plasma beta-endorphin, pain and anxiety were measured in patients before, during, and 1 and 3 hours following oral surgery. Diazepam and fentanyl blocked the stress induced increase in plasma beta-endorphin experienced by patients administered placebo. Moreover, intra-operative anxiety and post-operative pain appear to constitute independent and possibly equipotent stimuli for release of pituitary beta-endorphin in humans.
D001007:Anxiety / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D004723:Endorphins / Q000097:blood*; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D008964:Molar, Third / Q000601:surgery; D010149:Postoperative Pain / Q000378:metabolism; D010919:Placebos; D001615:beta-Endorphin
D004723:Endorphins; D010919:Placebos; D001615:beta-Endorphin; D003975:Diazepam; D005283:Fentanyl