Effect of interferons on dengue virus multiplication in cultured monocytes/macrophages.
The effects of interferons on dengue virus multiplication in cultured human and mouse monocytes/macrophages were studied. Interferon treatment before, but not after virus inoculation suppressed virus multiplication dose-dependently. Recombinant human leukocyte A interferon was as effective as ordinary human fibroblast interferon in suppressing dengue virus multiplication in cultured human monocytes. Human monocytes, a population of non-proliferating cell lineage, maintained their interferon-mediated antiviral state for a few days after removal of the interferons.
D000818:Animals; D000914:Antibodies, Viral / Q000502:physiology; D002478:Cells, Cultured; D003715:Dengue / Q000382:microbiology / Q000628:therapy; D003716:Dengue Virus / Q000502:physiology*; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009000:Monocytes / Q000382:microbiology*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
D000914:Antibodies, Viral; D007372:Interferons