[Proliferation of scirrhous type of gastric carcinoma and its treatment].
An attempt was made to clarify the clinical prognosis of scirrhous type of gastric carcinoma and to improve its treatment. The cases of gastric carcinoma operated and histologically well analyzed from 1969 to 1973 was 178, and scirrhous type was included in 52%. Advanced carcinoma (more than ss alpha) was 80% in scirrhous type and 40% in non-scirrhous type. Five year survival rate in scirrhous type was 45% and 59% in non-scirrhous type. (P divided by 0.09). In pm carcinoma, however, the 5 year survival rate of scirrhous type was higher than that of non-scirrhous type (P divided by 0.06). Between the primary lesions and lymphatic metastasis, histologic type was not the same in 70%. The survival rate of scirrhous type in lymphatic metastasis was again higher than that of the non-scirrhous type. Mitotic index was 18.6 +/- 8.6 in scirrhous type, 52.8 +/- 13.5 in medullary type, 54.1 +/- 16.5 in intermediate type and 53.3 +/- 11.5 in non-cancerous gastric epithelium. For the scirrhous type with a large amount of highly degenerated interstitial and poor blood vessel supplying, many doses of chemotherapeutic agents may be necessary, and, especially, cytostatic agents should be administered for long periods.
D002293:Adenocarcinoma, Scirrhous / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008207:Lymphatic Metastasis; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*