[Experimental study of the interferonogenic and antiviral activity of biologically active substances].
The results of screening of five national preparations for the interferon-inducing activity in white mice by various doses, schedules and routes of administration are presented. Their capacity to protect the animals against influenza, tick-borne encephalitis, and herpes viruses was evaluated. Cuthizon, zimosan, tiloron and its analogue IC-32 induced in mice endogenous interferon production in amounts from 40 to 640 IU50/ml. Tiloron, prodigiozin, and zimosan were found to be effective against influenza. Protective effect of zimosan in combination with polyguacyl was observed against tick-borne encephalitis.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy; D007369:Interferon Inducers / Q000494:pharmacology* / Q000627:therapeutic use; D007372:Interferons / Q000097:blood; D007739:L Cells / Q000382:microbiology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D013997:Time Factors; D014776:Virus Cultivation
D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D007369:Interferon Inducers; D011135:Polysaccharides, Bacterial; D007372:Interferons
Eksperimental'noe izuchenie interferonogennoĭ i protivovirusnoĭ aktivnosti nekotorykh biologicheski aktivnykh veshchestv.