Initial step in catabolism of glucose by the meningopneumonitis agent.
The relative rates of catabolism of glucose and glucose-6-phosphate by intact-cell suspensions of the meningopneumonitis agent, a member of the psittacosis group (Chlamydia), and the properties of the hexokinase and glucose-6-phosphate dehydrogenase of these suspensions were investigated. It is proposed that the hexokinase is a host enzyme bound to the surface of the meningopneumonitis cell and that glucose-6-phosphate is the first substrate in the conversion of hexose to pentose to be attacked by enzymes synthesized by the meningopneumonitis agent.
D000818:Animals; D002245:Carbon Dioxide / Q000096:biosynthesis; D002247:Carbon Isotopes; D002474:Cell-Free System; D002642:Chick Embryo / Q000201:enzymology; D002689:Chlamydia / Q000201:enzymology*; D005947:Glucose / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism*; D006600:Hexosephosphates / Q000378:metabolism*; D010429:Pentoses / Q000096:biosynthesis; D013696:Temperature; D014357:Trypsin / Q000494:pharmacology
D002247:Carbon Isotopes; D006600:Hexosephosphates; D010429:Pentoses; D002245:Carbon Dioxide; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D014357:Trypsin; D005947:Glucose