title: Antimeasles vaccination by natural routes--experimental background and practical consequences.
abstract: A limited number of passages (up to 10) in human diploid cells (HDC) does not lead to changes in the phenotypic markers indicating the degree of attenuation of the vaccine strains of measles virus (Schwarz, Leningrad-16, Edmonston-Zagreb). At the same time, the increase in virus titer and the acquiring of immunogenicity when administered by nonparenteral (conjunctival, nasal) routes represent the prerequisites of a convenient form of application of the measles vaccine prepared in HDC.
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D004848:Epithelium / Q000382:microbiology; D006387:Hemagglutination, Viral; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007372:Interferons / Q000276:immunology; D008214:Lymphocytes / Q000382:microbiology; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage* / Q000276:immunology; D008459:Measles virus / Q000276:immunology / Q000472:pathogenicity; D009000:Monocytes / Q000382:microbiology; D009924:Organ Culture Techniques; D013696:Temperature; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D010948:Viral Plaque Assay; D014779:Virus Replication
chemical_list: D008458:Measles Vaccine; D014613:Vaccines, Attenuated; D007372:Interferons