title: Cyclic AMP and steroidogenesis in superovulated rat ovaries.
abstract: During the gonadotropin stimulated differentiation of ovarian follicles into corpora lutea, the concentrations of total cyclic AMP and protein bound cyclic AMP increased only marginally. In contrast, there was a 10 fold increase in progesterone production. After acute stimulation of luteinized ovaries with choriogonadotropin total cyclic AMP levels increase more than 6 times while bound cyclic AMP and plasma progesterone rose by 80 and 60% respectively. Our results question the role of cyclic AMP in the basal production of progesterone by the ovary, and suggest a relationship between bound cyclic AMP and progesterone synthesis only exists after acute gonadotropin stimulation.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology; D007700:Kinetics; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D010060:Ovulation; D011374:Progesterone / Q000096:biosynthesis* / Q000097:blood; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013480:Superovulation
chemical_list: D006064:Gonadotropins, Equine; D011506:Proteins; D011374:Progesterone; D000242:Cyclic AMP