[Reciprocal potentiation of the bronchoconstrictor activity of histamine and 5-hydroxytryptamine in the guinea pig].
Bronchoconstriction due to aerosolized histamine (H), 5-hydroxytryptamine (5-HT) and combined administration of both substances has been studied on 53 guinea-pigs. The results are consistant with: a major bronchoconstrictor effect obtained with H than with 5-HT; a potentiation of the individual effects of H and 5-HT in two thirds of the guinea-pigs, by the combined administration of the two drugs simultaneously; a more potent antagonistic effect of Ketanserin against 5-HT than against H; potentiation due to the combined administration of 5-HT and H is suppressed by Ketanserin; neither vagal reflexes nor cholinergic receptors seem to interfere with the bronchospastic response of the guinea-pig to H and 5-HT.
D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D006633:Histamine Antagonists; D007650:Ketanserin; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D006633:Histamine Antagonists; D010880:Piperidines; D012702:Serotonin Antagonists; D012701:Serotonin; D006632:Histamine; D007650:Ketanserin
Potentiation réciproque de l'activité bronchoconstrictrice de l'histamine et de la 5-hydroxytryptamine chez le cobaye.