Comparative benzo[a]pyrene metabolite patterns in fish and rodents.
Benzo[a]pyrene is converted to 3-hydroxybenzo[a]pyrene, 9-hydroxybenzo[a]pyrene, benzo[a]pyrene-4,5-dihydrodiol, benzo[a]pyrene-7,8-dihydrodiol, benzo[a]pyrene-9,10-dihydrodiol, and benzo[a]pyrene quinones by postmitochondrial supernatant or microsomes in such fish as the rainbow trout, flounder, salmon, mullet, little skate, Fundulus grandis, and sea catfish. It is also now well-established that many fish convert benzo[a]pyrene to potent mutagenic metabolites as has been demonstrated with the Ames test, especially when the fish are induced with Aroclor 1254 or 3-methylcholanthrene. The metabolite patterns obtained at different substrate concentrations levels indicate that the metabolism is more complex at low concentrations when metabolites are recycled in the in vitro system.
D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism*; D005399:Fishes / Q000378:metabolism*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism; D051381:Rats / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity
D001580:Benzopyrenes; D009153:Mutagens; D001564:Benzo(a)pyrene