Synthesis of 1,4-diamino-anthraquinone-2-sulfonic acid derivatives coupled to dextran as carriers for interferon.
Ten compounds (II, VI-XIV) of the simpler structure similar to Cibacron Blue were synthesized and bound to dextran with ether binding. Eight obtained high-molecular-weight compounds (D-VII to D-XIV) displayed in biological assays high affinity for mouse or human interferons.
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D006801:Humans; D007372:Interferons; D051379:Mice; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
D000880:Anthraquinones; D013451:Sulfonic Acids; D007372:Interferons