title: Ornithine decarboxylase may be a multifunctional protein.
abstract: Ornithine decarboxylase may undergo posttranslational modifications which alter its function. Both transamidation of glutamine residues in the enzyme catalyzed by TGase and phosphorylation of serine and threonine residues catalyzed by a polyamine-stimulated protein kinase have been demonstrated. Data are presented which suggest that these modifications result in translocation of the modified protein to the nucleolus where it regulates the activity of RNA polymerase I to transcribe rDNA, the only active nucleolar genes. Transamidation of specific proteins with primary amines catalyzed by intracellular TGase may be an important posttranslational modification, capable of altering genetic transcription. The rapid half-life of ODC (10-15 min) may be related to rapid posttranslational modification with loss of enzymatic activity rather than to protein degradation.
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D004790:Enzyme Induction / Q000187:drug effects; D006168:Guinea Pigs; D006728:Hormones / Q000494:pharmacology; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012318:RNA Polymerase I / Q000378:metabolism; D051381:Rats; D011503:Transglutaminases / Q000378:metabolism
chemical_list: D006728:Hormones; D007527:Isoenzymes; D011073:Polyamines; D012313:RNA; D011503:Transglutaminases; D012318:RNA Polymerase I; D009955:Ornithine Decarboxylase