title: The pathogenesis of obesity.
abstract: This article clarifies current understanding of the etiology and pathogenesis of obesity, the most common metabolic disorder in humans. Among the factors covered are adipocyte hyperplasia and hypertrophy, setpoint hypothesis, disorders of energy intake, disorders of energy expenditure, thermic effect of food, adaptive thermogenesis, and biochemical defects resulting in obesity.
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D001833:Body Temperature Regulation; D001835:Body Weight; D002874:Chromosome Mapping; D004734:Energy Metabolism; D005247:Feeding Behavior; D006801:Humans; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics / Q000503:physiopathology*; D005082:Physical Exertion; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014697:Ventromedial Hypothalamic Nucleus / Q000503:physiopathology; D014882:Water-Electrolyte Balance
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase