Substance P in renal afferent perikarya identified by retrograde transport of fluorescent dye.
Substance P immunoreactivity in the afferent pathways to the kidney of the cat was investigated by using combined retrograde fluorescent dye labeling and indirect immunofluorescent techniques. Substance P was identified in 24% of dye-labeled renal afferent neurons in the dorsal root ganglia from L1 to L3. By comparison, 29% of all cells in the lumbar ganglia were substance P-positive. These data indicate that substance P may be involved in the transmission of afferent input from the kidney to the central nervous system.
D000818:Animals; D002415:Cats; D005455:Fluorescent Antibody Technique; D005727:Ganglia, Spinal / Q000378:metabolism*; D007668:Kidney / Q000294:innervation*; D009475:Neurons, Afferent / Q000378:metabolism; D013373:Substance P / Q000378:metabolism*
D013373:Substance P