Alkaline phosphatase activity of the mouse.
Plasma alkaline phosphatase (PAP) activity of young adult CD mice is low (e.g. 1/10th of that of rat) and is lower in males than in females. The variability of PAP was assessed in groups of mice kept under different husbandry conditions (e.g. caging, diet, SPF). PAP activities of fed and fasted mice are similar. After comparing their acrylamide electrophoresis and the action of several inhibitors upon the PAP and the alkaline phosphatase of various organ extracts, it is suggested that the two isoenzymes of PAP (indicated by heat inhibition) probably arise from bone and liver.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005215:Fasting; D005260:Female; D006207:Half-Life; D006709:Homoarginine / Q000494:pharmacology; D006358:Hot Temperature; D007978:Levamisole / Q000494:pharmacology; D008274:Magnesium / Q000378:metabolism; D008297:Male; D051379:Mice; D009439:Neuraminidase / Q000378:metabolism
D006709:Homoarginine; D007978:Levamisole; D000469:Alkaline Phosphatase; D009439:Neuraminidase; D008274:Magnesium