[Interferon-inducing and antiviral activity of dsRNA of yeast origin].
The paper describes derivation of double-stranded RNA from K plasmid of Sachcaromyces cerevisiae yeast by means of electrophoresis in agar gel and by differential salting out with 4 M lithium chloride. Studies in vitro and in vivo demonstrated a high interferon-inducing and antiviral activity of dsRNA preparations from the yeast plasmid.
D000818:Animals; D000998:Antiviral Agents; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy; D007369:Interferon Inducers; D007372:Interferons / Q000032:analysis; D007739:L Cells / Q000187:drug effects; D004680:Maus Elberfeld virus / Q000187:drug effects; D051379:Mice; D010957:Plasmids; D012330:RNA, Double-Stranded / Q000494:pharmacology* / Q000627:therapeutic use; D012331:RNA, Fungal / Q000494:pharmacology* / Q000627:therapeutic use; D012441:Saccharomyces cerevisiae; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000998:Antiviral Agents; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D007372:Interferons
Interferonindutsiruiushchaia i protivovirusnaia aktivnost' dsRNK drozhzhevogo proiskhozhdeniia.