title: Brain monoaminergic control of male reproductive behavior. III. Norepinephrine and the post-ejaculatory refractory period.
abstract: The present study was performed to examine the role of brain norepinephrine in the control of copulation and the post-ejaculatory refractory period in the male rat. Disruption of central noradrenergic systems was achieved by (1) selective electrolytic lesion of noradrenergic cell bodies in the locus coeruleus or (2) administration of specific inhibitors of norepinephrine synthesis, sodium diethyldithiocarbamate (DDC) or 1-phenyl-3-(2-thiazolyl)-2 thiourea (U-14, 624). Electrolytic lesions of the locus coeruleus produced a significant increase in the duration of the post-ejaculatory refractory period and its concomitant 22-kHz ultrasonic vocalization. Administration of norepinephrine synthesis inhibitors significantly increased both mount and intromission latencies and caused a dramatic increase in the length of the post-ejaculatory refractory period. These findings support the hypothesis that norepinephrine-containing neural pathways are involved in the control of sexual arousal and suggest that a functional noradrenergic system is essential to the integrity of normal masculine copulatory behavior.
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000502:physiology*; D003307:Copulation / Q000502:physiology*; D004050:Ditiocarb / Q000494:pharmacology; D004542:Ejaculation / Q000187:drug effects; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D009434:Neural Pathways / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D010668:Phenylthiazolylthiourea / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000502:physiology; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
chemical_list: D011941:Receptors, Adrenergic; D010668:Phenylthiazolylthiourea; D004050:Ditiocarb; D009638:Norepinephrine