title: Proteoglycans and cell adhesion. Their putative role during tumorigenesis.
abstract: In this review, evidence that proteoglycans are involved in cell adhesion and related behavior is considered, together with their putative role(s) during tumorigenesis. Proteoglycans are large, carboxylated and/or sulfated structures that interact with specific binding sites on cell surfaces. Their distribution and synthesis in tissues alter with the onset of tumorigenesis so that hyaluronic acid is generally increased and heparan sulfate decreased in the developing tumor and surrounding tissue. However, the precise role of proteoglycans during the tumorigenic process is far from clarified. Data suggest any putative roles will be related to the adhesive properties that these molecules confer to cells. Hyaluronic acid and chondroitin sulfate appear to be weakly adhesive molecules that may promote 'transformed' characteristics when they occur on cells in large amounts. These characteristics include reduced cell spreading, increased cell motility, as well as reduced contact inhibition. Consistent with such properties, neither hyaluronic acid nor chondroitin sulfate are localized in specialized adhesion sites such as focal or close contacts. In contrast, heparan sulfate is associated with increased cell-substratum adhesion and is involved in the spreading of cells onto fibronectin and other substrata. Its presence is generally associated with reduced motility and with a well-spread morphology. Unlike hyaluronate and chondroitin sulfate, heparan sulfate is found in specialized contacts. These adhesive properties of proteoglycans predict an instructive role in tumor development, and recent experiments have defined an involvement of these molecules in metastatic arrest. Additional studies utilizing invasive and metastatic tumor variants including tumor cells that employ different mechanisms to invade are required to clarify the role of proteoglycans in tumor progression.
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000032:analysis; D002448:Cell Adhesion; D002465:Cell Movement / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D011508:Chondroitin Sulfate Proteoglycans / Q000502:physiology; D002809:Chondroitin Sulfates / Q000502:physiology; D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid / Q000502:physiology; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D011509:Proteoglycans / Q000032:analysis / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000032:analysis
chemical_list: D002352:Carrier Proteins; D011508:Chondroitin Sulfate Proteoglycans; D002809:Chondroitin Sulfates; D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid; D011509:Proteoglycans; D011956:Receptors, Cell Surface