Response of calves previously inoculated with inactivated herpes simplex virus to challenge exposure with Bovid herpesvirus 2.
Concentrated antigen of Herpes simplex virus (HSV) types 1 and 2, previously inactivated with Triton 100X, were inoculated into calves. Thirty-two days later the calves were challenge exposed either by the intradermal or the intravenous route with Bovid herpesvirus 2 (BHV 2). The HSV-immune calves responded to BHV 2 infection with clinical signs which were much less severe that those observed in the challenge control calves. The skin lesions in the calves exposed to intravenous inoculation of BHV 2, were fewer in the calves in the HSV-immune group, whereas they were heavily disseminated, covering the skin of the entire body, in the control calves. In the case of calves which received BHV 2 intradermally, the titer of the virus underwent a reduction of more than one log unit in the pre-immunized calves. The most significant serologic finding was that the HSV-preimmunized calves produced antibody to the BHV 2 challenge virus at an earlier time than did the control calves. The immunologic relationship between BHV 2 and HSV was confirmed by the results of this study.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D003429:Cross Reactions; D006564:Herpesviridae / Q000276:immunology* / Q000302:isolation & purification; D007114:Immunization; D009297:Nasal Mucosa / Q000382:microbiology; D018139:Simplexvirus / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral