Direct infusion of EOE-13 into the hepatic artery. Experimental evaluation of safety in monkeys.
Ethiodized Oil Emulsion 13 (EOE-13) is an intravenous liver-spleen specific CT contrast agent. We infused EOE-13 directly into the hepatic arteries of five rhesus monkeys. Normal saline was administered in the same fashion in two control animals. Serial laboratory studies showed no major toxicity over a seven-day period. Intra-arterial EOE-13 has potential usefulness in the evaluation of hepatic artery infusion chemotherapy.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D004998:Ethiodized Oil / Q000633:toxicity*; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging*; D007958:Leukocyte Count; D008099:Liver / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000473:pathology; D008253:Macaca mulatta; D011859:Radiography; D013997:Time Factors
D004998:Ethiodized Oil; D001219:Aspartate Aminotransferases