Normal frequency of anti-thyroglobulin antibodies in hyperendemic areas of malaria: relevance to the understanding of autoantibody formation in malaria.
Sera from 280 inhabitants from the Upper-Volta villages of Donsé and Oursi were screened for the presence of anti-thyroglobulin antibodies (anti-Tg Ab) by the classical passive haemagglutination technique. Precipitant malarial antibodies and immunoglobulins (IgG, IgA, IgM) levels were concomitantly evaluated. Although 90% of the individuals studied had antibodies against malaria, a disease known to be associated with autoantibody (auto-Ab) production a normal frequency of anti-Tg Ab was observed in both Donsé and Oursi villages. This normal frequency of anti-Tg Ab contrasting to the previously reported increased frequency of other auto-Ab in individuals exposed to malaria, is additional evidence that the auto-Ab production that takes place during malaria infection is not the result of a generalized and non-specific activation of autoreactive cells by parasite derived mitogens.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002050:Burkina Faso; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007223:Infant; D008288:Malaria / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013954:Thyroglobulin / Q000276:immunology*; D000511:alpha-Macroglobulins / Q000378:metabolism
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007136:Immunoglobulins; D000511:alpha-Macroglobulins; C032306:polyclonal B cell activator; D013954:Thyroglobulin