Influence of recF on spontaneous mutation in Escherichia coli.
A recF mutation increased the spontaneous mutation rate for mutations to histidine and tryptophan independence, and to streptomycin resistance but not significantly to rifampicin resistance. The results suggest the recF gene may have a role in maintaining DNA replication fidelity.
D001426:Bacterial Proteins / Q000235:genetics; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005796:Genes; D005798:Genes, Bacterial; D006639:Histidine / Q000378:metabolism; D009154:Mutation; D012293:Rifampin / Q000633:toxicity; D013307:Streptomycin / Q000633:toxicity; D014364:Tryptophan / Q000378:metabolism
D001426:Bacterial Proteins; D006639:Histidine; D014364:Tryptophan; D012293:Rifampin; D013307:Streptomycin