Leukocyte histamine release and humoral changes during oral and subcutaneous hyposensitization of grass pollen allergic children.
Thirty-one children with seasonal hay fever, sensitive to rye grass by skin test, RAST, and leukocyte histamine release, received preseasonal hyposensitization with a rye grass pollen extract either subcutaneously (cumulative dose 40,000 PNU) or orally (cumulative dose 400,000 PNU). While there was a significant (p less than 0.005) increase in specific serum IgG-antibodies and a decrease (p less than 0.005) of leukocyte sensitivity in the subcutaneously treated group, oral treatment with an aqueous pollen extract could not be demonstrated to be immunologically effective.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic; D005069:Evaluation Studies as Topic; D006636:Histamine Release; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D012434:Secale
D007074:Immunoglobulin G