[Properties of double-stranded RNA as an interferon inducer].
The stability and activity of double-stranded RNA (dsRNA) preparations as interferon inductors were studied. They were found to be stable upon long storage and ultrasonic treatment for aerosol preparation. Data on dsRNA toxicity for mice and rabbits are presented. The kinetics of interferon production and its distribution in tissues in relation to the routes of inoculation were studied. Investigation of dsRNA antiviral activity in various experimental viral infections demonstrated a protective effect of the preparation after a single prophylactic administration of the inductor.
D000336:Aerosols; D000818:Animals; D000998:Antiviral Agents; D003090:Coliphages; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D007369:Interferon Inducers; D007372:Interferons / Q000097:blood; D051379:Mice; D012330:RNA, Double-Stranded / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D012367:RNA, Viral / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors; D014777:Virus Diseases / Q000188:drug therapy
D000336:Aerosols; D000998:Antiviral Agents; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012367:RNA, Viral; D007372:Interferons
Svoĭstva dvuspiral'noĭ RNK kak induktora interferona.