title: Plasma apoprotein changes after selective inhibition of hepatic triglyceride lipase in rat.
abstract: Selective inhibition of hepatic triglyceride lipase (HTGL) by specific antibodies in rats led to an altered VLDL apoprotein composition. Apoprotein analysis by isoelectric focusing revealed a new protein band in VLDL and an increase in apoprotein E (apo E) content. Apoproteins in LDL and HDL remained unchanged. Electronmicroscopy showed a significant increase in particle size of VLDL from 452 to 497 A with no significant changes in LDL and HDL diameters.
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000097:blood*; D001057:Apolipoproteins E / Q000097:blood; D007525:Isoelectric Focusing; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000276:immunology; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000201:enzymology*; D008854:Microscopy, Electron; D051381:Rats; D013997:Time Factors; D005719:gamma-Globulins / Q000494:pharmacology
chemical_list: D001053:Apolipoproteins; D001057:Apolipoproteins E; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D005719:gamma-Globulins; D008049:Lipase