[Artificial immunogens from enterobacteria. I. The immunogenicity of conjugates of the O-polysaccharide from Salmonella typhimurium with synthetic polyelectrolytes].
A synthetic polysaccharide immunogen has been obtained by the conjugation of S. typhimurium nonimmune O-polysaccharide with a membrane-active adjuvant (the copolymer of acrylic acid and N-vinylpyrrolidone). The importance of the method used for the conjugation of O-polysaccharide with a synthetic carrier in enhancing its immunogenicity is shown.
D000179:Acrylates / Q000138:chemical synthesis* / Q000276:immunology; D000276:Adjuvants, Immunologic; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D000942:Antigens, Bacterial / Q000276:immunology*; D004573:Electrolytes / Q000276:immunology; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D019081:O Antigens; D011135:Polysaccharides, Bacterial / Q000138:chemical synthesis* / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000179:Acrylates; D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D004573:Electrolytes; D019081:O Antigens; D011135:Polysaccharides, Bacterial; C036658:acrylic acid
Iskusstvennye immunogeny iz énterobakterii. Soobshchenie I. Immunogennost' kon"iugatov O-polisakharida iz Salmonella typhimurium s sinteticheskimi poliélektrolitami.