title: Progress in experimental pathology in the People's Republic of China. Action of pppA2'p5'A2'p5'A on the immune system.
abstract: Enhancement of phagocytosis of macrophages and the activity of natural killer cells by pppA2'p5'A2'p5'A (2'-5'P3A3) has been described. During the action of 2'-5'P3A3 on these immune cells, neither CaCl2 nor other agents were used to introduce 2'-5'P3A3 into the cells. The action of 2'-5'P3A3 on macrophages might be mediated by a surface receptor for 2'-5'P3A3. This is the first report of an oligonucleotide that confers biological action through a receptor. Activation of the immune system by 2'-5'P3A3 without using the agents like CaCl2, and the discovery of a 2'-5'P3A3 receptor in macrophages suggest that 2'-5'P3A3 and its derivatives may have some practical use.
mesh_terms: D000227:Adenine Nucleotides / Q000494:pharmacology*; D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007372:Interferons / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D009843:Oligoribonucleotides / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D011983:Receptors, Purinergic / Q000378:metabolism
chemical_list: D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; D011983:Receptors, Purinergic; C048575:pppA2'p5'A2'p5'A receptor; C016964:adenosine triphosphate adenosine monophosphate adenosine monophosphate; D007372:Interferons; D002122:Calcium Chloride