Neomorphogenesis of blood vessels in rabbit skin induced by a highly purified monocyte-derived polypeptide (monocyto-angiotropin) and associated tissue reactions.
Chemotropic morphogenesis of new blood vessel patterns with active haemodynamics in the skin of rabbits was induced by intradermal injection of highly purified monocyto-angiotropin (MAT), one of the low-molecular-weight (4,500) polypeptide monokines exuded by activated mammalian (porcine) monocytes (macrophage type) on their culture in serum-free, fully synthetic media. Evidence is presented that neohypervascularization of the skin is associated with enhanced tissue function as represented by hair growth. Exclusively in the area of MAT injection, numerous capillary-like vessel formations arose from preexisting vessels, and the quiescent hair follicles (telogen) were activated to growing ones (anagen) within 1-2 weeks.
D000818:Animals; D005260:Female; D006197:Hair / Q000254:growth & development; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D015846:Monokines; D009389:Neovascularization, Pathologic; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D011817:Rabbits; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology
D036341:Intercellular Signaling Peptides and Proteins; D015846:Monokines; D010455:Peptides; D011506:Proteins; C044581:monocyto-angiotropin