title: Secondary antithyroid action of drugs in relation to structure.
abstract: Molecular interactions between iodine and disulfiram, clomethiazole, and tolnaftate were investigated by electron spectroscopy. Iodine forms charge transfer complexes with these molecules, with 1:1 stoichiometry and of the n-sigma type. The formation constants were compared with those obtained with antithyroid molecules. Only disulfiram appears to have any effect on the intrathyroid cycle of iodine.
mesh_terms: D013956:Antithyroid Agents / Q000494:pharmacology*; D002251:Carbon Tetrachloride; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002719:Chlormethiazole; D004221:Disulfiram; D007455:Iodine; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014047:Tolnaftate
chemical_list: D013956:Antithyroid Agents; D014047:Tolnaftate; D002719:Chlormethiazole; D007455:Iodine; D002251:Carbon Tetrachloride; D004221:Disulfiram