Beta-adrenoceptor and epoprostenol (prostacyclin) responsiveness of lymphocytes in migraine patients.
Beta-adrenoceptor blocking drugs are of prophylactic value in some patients with migraine. Beta-adrenoceptor responsiveness as measured by lymphocyte cAMP responsiveness to isoprenaline has, therefore, been compared in ten untreated classical migraine patients and ten matched non-migraine control subjects. Lymphocyte responsiveness to epoprostenol (prostacyclin, PGI2) was also compared. No difference in response to either agent was found between the two groups. A generalized abnormality of beta-adrenoceptor function does not appear to be present in classical migraine, but a defect localized to specific vascular regions cannot be excluded.
D000242:Cyclic AMP / Q000097:blood; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008881:Migraine Disorders / Q000097:blood*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D011464:Epoprostenol; D000242:Cyclic AMP; D007545:Isoproterenol