Effects of dopamine and substance P infusion on gastric acid secretion in Pavlov and Heidenhain pouched dogs.
The effects of dopamine and Substance P infusion on gastric secretion have been evaluated in Pavlov and Heidenhain pouched dogs. Basal gastric acid secretion was significantly inhibited during both dopamine and Substance P infusion in conscious pavlov pouched dogs. Substance P inhibited tetragastrin-stimulated gastric secretion much more than dopamine. These data suggest that the effects of dopamine and Substance P on gastric secretion depend on the vagal condition.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D013270:Stomach / Q000294:innervation / Q000502:physiology; D013373:Substance P / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology
D013373:Substance P; D004298:Dopamine