Lymphosarcoma and persistent feline leukemia virus infection of pet cats: a system to study responses during extracorporeal treatments.
Pet cats, persistently infected with feline leukemia virus and having lymphosarcoma, were treated by extracorporeal immunoadsorption using Staphylococcus aureus Cowan I (which has protein A on its surface) to remove immunoglobulin G and circulating immune complexes. Complete viral clearance and long-lasting tumor regression were achieved following such treatments in 9 of 16 cats. In addition, in vitro immunologic assays have been developed that are useful in the clinical evaluation of cats during treatment.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002371:Cat Diseases / Q000276:immunology / Q000628:therapy*; D002415:Cats; D007163:Immunosorbent Techniques; D005256:Leukemia Virus, Feline / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D013205:Staphylococcal Protein A / Q000627:therapeutic use*; D014759:Viral Envelope Proteins / Q000276:immunology
D000914:Antibodies, Viral; D013205:Staphylococcal Protein A; D014759:Viral Envelope Proteins