Dose-response relationship of a topical nasal decongestant: phenylpropanolamine.
By means of anterior rhinomanometry, the decongestant effect of topically applied phenylpropanolamine (PPA) was evaluated in 40 patients with nasal obstruction. A dose-response relation was obtained for 0.5, 2.5 and 5.0% PPA solution, with the maximum effect (40% decongestion) found with the 2.5% solution. The decongestant effect was comparable to that induced by physical exercise (50% decongestion). It is concluded that PPA nose-drops are effective and offer an attractive alternative to some of the commonly used nasal decongestants.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects*; D003139:Common Cold / Q000188:drug therapy / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014663:Nasal Decongestants / Q000494:pharmacology; D009298:Nasal Polyps / Q000188:drug therapy / Q000503:physiopathology; D010665:Phenylpropanolamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D014663:Nasal Decongestants; D010665:Phenylpropanolamine