title: Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse.
abstract: The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC.
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D008815:Mice, Inbred Strains / Q000276:immunology; D009693:Nucleic Acid Hybridization; D013045:Species Specificity
chemical_list: D006183:H-2 Antigens; D004262:DNA Restriction Enzymes