Effects of chemical inducers on the Epstein-Barr virus cycle in epithelial/nasopharyngeal carcinoma hybrid cell line.
We have studied the induction of Epstein-Barr virus (EBV)-specific antigens in nasopharyngeal carcinoma hybrid cells by treatment with the tumor promotor 12-0-tetradecanoylphorbol-13-acetate (TPA), hydrogen peroxide (H2O2) and n-butyric acid. The intensity of EBV induction by these drugs was in the order of n-butyric acid----TPA----H2O2. Furthermore, the combination of H2O2 or TPA and n-butyric acid acted synergistically on EBV-induced antigens.
D002087:Butyrates / Q000633:toxicity; D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity*; D009303:Nasopharyngeal Neoplasms / Q000139:chemically induced* / Q000382:microbiology; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010704:Phorbols / Q000633:toxicity*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D002087:Butyrates; D010704:Phorbols; D006861:Hydrogen Peroxide; D013755:Tetradecanoylphorbol Acetate