Demonstration of substance P immunoreactivity in the nucleus dorsalis of human spinal cord.
Substance P immunoreactivity has been detected in varicosities around cell bodies of the nucleus dorsalis (Clarke's column) of the human spinal cord. This immunostaining probably represents neuropeptide immunoreactivity either in the nerve terminals of spinal interneurone, descending projections or in the primary dorsal root afferents which have been shown previously to synapse with the neurones of Clarke's column. The presence of substance P immunoreactivity in the human nucleus dorsalis suggests a role of substance P in the transmission of proprioceptive and exteroceptive information from the lower trunk and limbs to the cerebellum.
D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011434:Proprioception; D013116:Spinal Cord / Q000276:immunology*; D013373:Substance P / Q000276:immunology*; D014018:Tissue Distribution
D013373:Substance P