[Sodium permeability of cardiac cells exposed to nembutal].
A study was made of the effect of anesthetic concentrations of pentobarbital on sodium permeability of the myocardial cell membranes by recording action potentials of the frog myocardial cells, tension fixation by the double sucrose bridge method on frog atrial trabecula and by the voltage clamp method during tension fixation on a rat isolated myocardial cell membrane. It is concluded that pentobarbital has no effect on rapid sodium current of the myocardial cell membranes.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology*; D011896:Rana temporaria; D012964:Sodium / Q000378:metabolism*
D007473:Ion Channels; D012964:Sodium; D010424:Pentobarbital
Natrievaia pronitsaemost' serdechnykh kletok pri deĭstvii nembutala.