Lysophosphatidylcholine decreases single channel conductance of inward rectifier K channel in mammalian ventricular myocytes.
Effect of lysophosphatidylcholine (LPC) on the inward rectifier K channel of the isolated guinea pig ventricular cell was studied using patch clamp technique. In that LPC (100 microM) decreased the magnitude of the single channel conductance from 48 +/- 5 pS (mean and S.D., n = 5) to 12 +/- 9 pS (n = 8), this event may be the prime factor related to the alleged LPC-induced depolarization of cardiac tissues.
D000818:Animals; D001696:Biomechanical Phenomena; D004553:Electric Conductivity; D006168:Guinea Pigs; D006352:Heart Ventricles; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*
D007473:Ion Channels; D008244:Lysophosphatidylcholines; D011188:Potassium