Inhibition of contact lens-induced corneal neovascularization in radial keratotomized rabbit eyes.
Cellulose acetate butyrate contact lenses were fitted for extended wear on 28 rabbits 6 weeks after radial keratotomy. Fourteen rabbits received 0.03% flurbiprofen to one eye and vehicle solution to the contralateral control eye, while the other 14 received 1% prednisolone acetate to one eye and vehicle solution to the contralateral control eye four times each day in a double-blind fashion. The eyes were photographed and graded weekly with a standardized slit-lamp grading method. After 6 weeks, inhibition of corneal neovascularization was found with flurbiprofen (p = 0.001), while there was a trend toward inhibition of corneal neovascularization with prednisolone acetate (p = 0.076). We also found a significant vehicle effect, with hydroxypropyl methylcellulose, the more viscous vehicle, suppressing corneal neovascularization more than polyvinyl alcohol (p = 0.004).
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea / Q000098:blood supply / Q000601:surgery*; D005480:Flurbiprofen / Q000627:therapeutic use*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D011142:Polyvinyl Alcohol / Q000494:pharmacology; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011422:Propionates / Q000627:therapeutic use*; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014677:Pharmaceutical Vehicles; D011422:Propionates; D065347:Hypromellose Derivatives; D005480:Flurbiprofen; C009935:prednisolone acetate; D011142:Polyvinyl Alcohol; D008747:Methylcellulose; D011239:Prednisolone