Leu-enkephalin binding to cultured human T lymphocytes.
Evidence is given for the existence of leu-enkephalin binding activity on the cell surface of a human lymphoid T line. Our data suggest that binding is due to receptor structures which in all likelyhood are lipoproteic, as is already known to be the case with the receptors present in the mammalian brain. In spite of these similarities, however, lymphocytes exhibit anomalous specificity as far as the binding toward opioid alkaloids and their inhibitors is concerned.
D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D019286:Endopeptidase K; D010450:Endopeptidases / Q000494:pharmacology; D004743:Enkephalin, Leucine / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D010741:Phospholipases A / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D011957:Receptors, Opioid; D004743:Enkephalin, Leucine; D010741:Phospholipases A; D010450:Endopeptidases; D019286:Endopeptidase K