[A study of prostatic tissue levels of ceftizoxime, cefoperazone and cefotaxime].
Prostatic tissue levels and serum levels of Ceftizoxime (CZX), Cefoperazone (CPZ) and Cefotaxime (CTX), after intravenous administration were studied in 82 patients with prostatic hypertrophy, who underwent transurethral surgery. CZX was found to be the most effective for treatment of prostatic infection, since its prostatic tissue level was considerably higher than the others, satisfactorily above the MIC level of most bacteria. The prostatic tissue levels were not correlated with prostate size. The levels in fibromuscular hyperplasia were significantly higher than in glandular hyperplasia.
D000368:Aged; D002438:Cefoperazone / Q000097:blood / Q000378:metabolism*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D015296:Ceftizoxime; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism
D002438:Cefoperazone; D015296:Ceftizoxime; D002439:Cefotaxime