[3-dimensional model of transcription and the mechanism of RNA elongation].
The spatial aspects of template-dependent synthesis of RNA have been considered. It has been concluded that the idea of helical translocation on DNA double helix does not correspond to the literary experimental data. An alternative model given here proposes that the growing end of an RNA molecule is capable of transient disconnection from its template without dissociation of the whole transcriptional complex and the steric hindrances imposed by DNA helical turns are relaxed via this disconnection. This supposition explains the way of RNA release, the template properties of nucleosome chains and also some features of interrelations between RNA and DNA during transcription.
D004247:DNA / Q000235:genetics / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D046911:Macromolecular Substances; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D012329:RNA, Bacterial / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D013698:Templates, Genetic; D014158:Transcription, Genetic
D046911:Macromolecular Substances; D012329:RNA, Bacterial; D012333:RNA, Messenger; D004247:DNA; D012321:DNA-Directed RNA Polymerases
Prostranstvennaia model' transkriptsii i mekhanizm élongatsii RNK.