title: The use of heparin as a simple cost-effective means of controlling background in nucleic acid hybridization procedures.
abstract: The use of heparin as a simple, effective and cheap substitute for conventional methods of controlling background in hybridization procedures is described and illustrated with reference to the use of DNA probes in filter and in situ hybridization. Possible specific mechanisms for this heparin effect are discussed.
mesh_terms: D000818:Animals; D004262:DNA Restriction Enzymes; D005260:Female; D006493:Heparin; D008297:Male; D051379:Mice; D009693:Nucleic Acid Hybridization
chemical_list: D006493:Heparin; D004262:DNA Restriction Enzymes