Acute effects of antagonist of S2-receptors.
Intravenous administration of ketanserin--a selective antagonist of serotonin receptors--to hypertensive patients resulted in an immediate marked drop of blood pressure accompanied by a decreased excretion of vanilmandelic acid and 5-hydroxy-3-indolylacetic acid. The drug was well tolerated by all patients without any serious complaints.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D006973:Hypertension / Q000188:drug therapy* / Q000652:urine; D007650:Ketanserin; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D014642:Vanilmandelic Acid / Q000652:urine
D010880:Piperidines; D012702:Serotonin Antagonists; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D007650:Ketanserin