Delayed-type hypersensitivity in mouse hepatitis virus infection in mice.
Delayed-type hypersensitivity in mouse hepatitis virus infection was studied with intraperitoneally infected mice. Twenty-four hours after eliciting injection with virus-infected cell lysate on day 8 postinfection, specific footpad swelling response was observed with infiltration of mononuclear cells. The response was not enhanced by cyclophosphamide treatment made 2 days before infection. The adoptive transfer of the response from infected mice to H-2 compatible recipients was successful with spleen T cells with Lyt 2-.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D006183:H-2 Antigens / Q000276:immunology; D006524:Hepatitis, Viral, Animal / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D006517:Murine hepatitis virus; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation
D006183:H-2 Antigens; D003520:Cyclophosphamide