Thyroxine regulates the activity and the concentration of synaptic plasma membrane Na,K-ATPase in the developing rat brain cortex.
The administration of thyroxine to neonatal rats stimulates the activity of synaptic membrane Na,K-ATPase in the brain cortex of euthyroid and hypothyroid animals. Thyroxine also increases NA,K-ATPase activity of isolated neuronal perikarya in neonatal rats. Binding studies employing [3H]ouabain indicate that the hormone increases the amount of Na,K-ATPase in the synaptic membranes of two-week-old rats. Thyroxine treatment however did not affect synaptic membrane Na,K-ATPase in rats aged 30 days. The results suggest that thyroid hormones are important for the maturation of the synaptic plasma membrane during the critical period of rat brain development.
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000201:enzymology* / Q000254:growth & development; D006980:Hyperthyroidism / Q000503:physiopathology; D007037:Hypothyroidism / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013570:Synaptic Membranes / Q000201:enzymology*; D013974:Thyroxine / Q000502:physiology*
D000254:Sodium-Potassium-Exchanging ATPase; D013974:Thyroxine