[Interrelation of disorders in gonadotropin and prolactin secretion and the activity of the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing disease].
An obvious relationship between changes in ACTH, gonadotrophin, prolactin and cortisol secretion was discovered on the basis of studying the basal ACTH, cortisol, LH, FSH and prolactin levels, as well as from correlative examination of the data obtained in 30 females with Icenko-Cushing's diseases. It is suggested that combined ACTH, gonadotrophin and prolactin secretion occurs in the active stage of the disease, whereas cortisol inhibits gonadotrophin production. A degree of gonadotrophic insufficiency is dependent on the ratio of excessive ACTH-cortisol secretion.
D000293:Adolescent; D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003480:Cushing Syndrome / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D006065:Gonadotropins, Pituitary; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone
Vzaimosviaz' narusheniĭ sekretsii gonadotropinov i prolaktina i aktivnosti gipotalamo-gipofizarno-nadpochechnikovoĭ sistemy pri bolezni Itsenko-Kushinga.