title: Solid tumors of children: chromosome abnormalities and the development of cancer.
abstract: Chromosome abnormalities in five solid tumors which occur predominantly in children and young adults are described. Four of the tumors are associated with rearrangements involving particular chromosome segments: deletion 13q14 in retinoblastoma, deletion 11p13 in Wilms' tumor, deletions/rearrangements of 1p (distal to band 1p31) in neuroblastoma, and translocation 22/autosome in Ewing sarcoma. Though aneuploidy for a number of chromosomes may occur in the fifth tumor, rhabdomyosarcoma, it has yet to be associated with a consistent marker arrangement. A general classification of chromosome abnormalities in cancer is presented. Possible roles for the gene changes produced by each class of chromosome abnormality in the development of cancer are discussed.
mesh_terms: D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005134:Eye Neoplasms / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D009447:Neuroblastoma / Q000235:genetics; D012175:Retinoblastoma / Q000235:genetics; D012208:Rhabdomyosarcoma / Q000235:genetics; D012512:Sarcoma, Ewing / Q000235:genetics; D014178:Translocation, Genetic; D009396:Wilms Tumor / Q000235:genetics