Alpha-adrenergic effects on insulin release from isolated pancreatic rat islets are influenced by alpha-glucosidase.
The modification of isolated pancreatic rat islets by pretreatment with alpha-glucosidase abolished the stimulatory action of phentolamine but not changed glucose induced insulin release. In modified islets the inhibitory effect of epinephrine was only slightly changed. The data indicated that alpha-adrenergic receptors may be selectively damaged by alpha-glucosidase.
D000818:Animals; D005959:Glucosidases / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D000520:alpha-Glucosidases / Q000494:pharmacology*
D007328:Insulin; D011942:Receptors, Adrenergic, alpha; D005959:Glucosidases; D000520:alpha-Glucosidases; D010646:Phentolamine