Substance P-immunoreactive processes on 5HT/SP-immunoreactive medullary cells.
Two-color immunoperoxidase staining has been used to localize substance P (SP)-immunoreactive processes on neurons in the caudal medulla that exhibited both serotonin (5HT)- and SP-immunoreactivity (5HTI/SPI cells). The punctate SP-immunoreactive processes were present on 5HTI/SPI cells in the raphe nuclei and ventral reticular formation. This close association suggests that activity in bulbospinal 5HT/SP pathways, which can influence sympathetic preganglionic neurons, may be affected by the release of SP in the brainstem.
D000818:Animals; D006224:Cricetinae; D007124:Immunoenzyme Techniques; D008526:Medulla Oblongata / Q000378:metabolism*; D008647:Mesocricetus; D011903:Raphe Nuclei / Q000378:metabolism; D012154:Reticular Formation / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
D012701:Serotonin; D013373:Substance P