Anaerobic infection in the neutropenic host: anti-endotoxin effect of polymyxin.
The neutropenic mouse model of endotoxin-associated anaerobic sepsis was used to evaluate the anti-endotoxic effect of polymyxin. Administered as two spaced doses after lethal challenge with Bacteroides fragilis polymyxin produced a statistically significant protective effect.
D000380:Agranulocytosis / Q000150:complications*; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D001442:Bacteroides Infections / Q000188:drug therapy / Q000209:etiology; D001441:Bacteroides fragilis; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D005260:Female; D006089:Gram-Negative Anaerobic Bacteria; D051379:Mice; D009503:Neutropenia / Q000150:complications*; D011113:Polymyxins / Q000627:therapeutic use*
D004731:Endotoxins; D011113:Polymyxins