Biliary excretion of ceftizoxime in humans.
Biliary concentrations of a new cephalosporin, ceftizoxime, were measured in bile collected in 8 cholecystectomized patients provided with T-tube drainage and in 14 patients where bile was obtained by puncture of the gall bladder and choledochus during cholecystectomy. In patients with external biliary drainage, a mean biliary peak of 150.3 +/- SEM 49.8 micrograms/ml has been observed 2 h after intravenous injection of 2 g of ceftizoxime; the antibiotic activity amounted still to 17.3 +/- 6.0 micrograms/ml after 6 h. Assays performed during operation showed the following simultaneous concentrations 1 h after 2 g of ceftizoxime given intravenously: serum: 85.3 +/- 8.1 micrograms/ml; main duct bile: 279.8 +/- 40.0 micrograms/ml; gallbladder bile: 119.9 +/- 19.4 micrograms/ml. These findings were compared with the biliary excretion of 8 other cephalosporins studied previously under the same conditions. The results of the present study suggest that administration of ceftizoxime may be effective in the treatment of biliary tract infections.
D001646:Bile / Q000378:metabolism*; D001662:Biliary Tract Surgical Procedures; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000378:metabolism; D015296:Ceftizoxime; D002763:Cholecystectomy; D003135:Common Bile Duct / Q000378:metabolism; D004322:Drainage; D005704:Gallbladder / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics
D015296:Ceftizoxime; D002439:Cefotaxime