title: Feline calicivirus infection in kittens borne by cats persistently infected with the virus.
abstract: On the basis of repeated isolation of feline calicivirus (FCV) from oropharyngeal swabs four to eight months after exposure to FCV strain 255, four carrier queen cats were identified. These cats gave birth to 16 kittens. Litters were individually housed with their mothers until nine weeks of age and were monitored virologically and serologically from birth until 15 weeks old. All kittens became infected between three and nine weeks old and shed FCV consistently for periods of three to 11 weeks. Clinical signs of FCV were observed in 11 kittens but none developed severe respiratory disease. At the time of initial infection maternal antibody titres in the kittens ranged from 1:4 to 1:24. Within one to three weeks of infection titres began to rise. The results indicated that kittens of queen cats persistently infected with FCV frequently experience mild or subclinical immunising infections.
mesh_terms: D000367:Age Factors; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002139:Caliciviridae / Q000276:immunology / Q000302:isolation & purification; D002353:Carrier State / Q000662:veterinary*; D002371:Cat Diseases / Q000276:immunology / Q000635:transmission*; D002415:Cats; D005260:Female; D009500:Neutralization Tests; D009960:Oropharynx / Q000382:microbiology; D010850:Picornaviridae Infections / Q000276:immunology / Q000635:transmission / Q000662:veterinary*; D011247:Pregnancy; D011645:Puerperal Infection / Q000276:immunology / Q000635:transmission / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral