title: Effects of cholecystokinin on apomorphine-induced changes of motility in rats.
abstract: Subcutaneous injection of apomorphine in small doses decreased, while larger doses increased motility in rats. The hypomotility was abolished by intracerebroventricular administration of sulphated cholecystokinin octapeptide [CCK-8(s)], but not by non-sulphated CCK-8 [CCK-8(ns)]. In contrast, the hypermotility was not influenced by CCK peptides. An antiserum directed against the C-terminus of CCK did not affect hypermotility induced by apomorphine but suppressed the apomorphine-induced hypomotility further. The results indicate that sulphated CCK-peptides contribute to the control of motility, which can be inhibited by apomorphine.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D011954:Receptors, Dopamine; D012844:Sincalide; D001058:Apomorphine