Regulative action of cyclic AMP and histamine on the immune response mediated by surface receptors of cells.
The study of the effect of histamine and cAMP on the proliferation of lymphocyte populations has shown that both substances induce a significant decrease in the rate of T-suppressor proliferation. This effect can be neutralized by methiamide--a blocker of H2-histamine receptors. The obtained results point out the possibility of a regulative effect of cAMP on the proliferation of T-suppressors. This effect is mediated by surface receptors of the cell which are similar to or identical with H2-histamine receptors.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D000242:Cyclic AMP / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology*; D008785:Metiamide; D051379:Mice; D008810:Mice, Inbred C57BL; D011738:Pyrilamine / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006635:Histamine H2 Antagonists; D008785:Metiamide; D006632:Histamine; D000242:Cyclic AMP; D011738:Pyrilamine