title: [Covalent derivatives of aminoacyl-tRNA-synthetases with substrates].
abstract: The possibility of participation of covalent enzyme substrate's derivatives in reactions catalyzed by aminoacyl-tRNA synthetases is discussed in connection with general principles of enzyme catalysis. Tryptophanylated and pyrophosphorylated forms of beef pancreas tryptophanyl-tRNA synthetase were identified, isolated and characterized and the expected role of these derivatives in the enzyme function is discussed.
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D011756:Diphosphates / Q000378:metabolism; D007700:Kinetics; D010179:Pancreas / Q000201:enzymology; D010766:Phosphorylation; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D011756:Diphosphates; D012346:RNA, Transfer, Amino Acyl; D000604:Amino Acyl-tRNA Synthetases
vernacular_title: Kovalentnye proizvodnye aminoatsil-tRNA-sintetaz s substratami.