Modulation of mast cell cAMP levels. A regulatory function of calmodulin.
Modulations of cyclic AMP (cAMP) levels and secretory capacity in both immunological and non-immunological stimulation of rat mast cells are influenced by the calmodulin inhibitor trifluoperazine. A model of a calcium-dependent joint regulation of cyclic nucleotide turnover in these two types of mast cell stimulation is presented.
D001202:Ascitic Fluid; D002147:Calmodulin / Q000502:physiology*; D000242:Cyclic AMP / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D002147:Calmodulin; D003189:p-Methoxy-N-methylphenethylamine; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases