A T-dependent plasma cell response: part of a graft-versus-host and host-versus-graft reaction in the rabbit spleen.
B-cell reactivity, as expressed in a plasma cell reaction may be part of a graft-versus-host or host-versus-graft reaction. Cell transfer experiments were able to prove this. Histological evidence is presented for the occurrence of the so-called "allogeneic effect" during a graft-versus-host or host-versus-graft reaction in the rabbit spleen. Cell suspensions containing both T- and B-cells give rise to a cellular and a humoral immunity reaction component upon transfer to histoincompatible recipients. This can also occur during a graft-versus-host reaction. This B-cell response is T-cell dependent.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D006087:Graft vs Host Reaction / Q000528:radiation effects; D006789:Host vs Graft Reaction; D007111:Immunity, Cellular; D010950:Plasma Cells / Q000276:immunology*; D011817:Rabbits; D013154:Spleen / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D014184:Transplantation, Homologous