Changes of lymphocyte beta-adrenergic receptors after surgical stress.
In this study the authors' purpose was to observe the effects of surgical stress on the number of lymphocyte beta-adrenergic receptors in hypertensive and normotensive subjects. It was noticed that after surgery a significant reduction occurred in the number of binding sites of lymphocytes of both hypertensive and normotensive subjects. The time course of recovery to the pre-operative values of binding sites varied between the two groups, being slower in normotensive than in hypertensive patients. This might suggest a different pattern of regulation of the beta-adrenergic receptor between hypertensive and normotensive subjects.
D000328:Adult; D000368:Aged; D000758:Anesthesia; D002462:Cell Membrane / Q000378:metabolism; D004082:Dihydroalprenolol; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*; D013514:Surgical Procedures, Operative
D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol