Effect of urinary alkalinization on renal changes produced by cationic albumin.
40-mg doses of human cationic (CA) or anionic (AA) albumin were administered intravenously to 48 normal female rats. Sodium bicarbonate (NaHCO3) was administered to 8 of these animals before CA or AA. Urine alkalinization caused increased renal CA excretion in CA-injected animals, which also showed marked reduction of the intensity of the renal changes produced by CA.
D000418:Albumins / Q000633:toxicity*; D000419:Albuminuria / Q000139:chemically induced*; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D002412:Cations; D005260:Female; D006863:Hydrogen-Ion Concentration; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D017693:Sodium Bicarbonate; D014556:Urine
D000418:Albumins; D001639:Bicarbonates; D002412:Cations; D017693:Sodium Bicarbonate