[Clinical study on stress protective action of cloxazolam in jaw surgery in double blind comparison to placebo (author's transl)].
An investigation in 50 patients has shown that biochemical measurements of dopamine-beta-hydroxylase (DBH), ACTH and cortisol as well as the concentration of glucose and insulin signal a reduction of surgical stress under the medication of the tranquilizer 10-chloro-11b-(2-chlorophenyl)-2,3,5,6,7,11b-hexahydrobenzo[6,7]-1,4-diazepino[5,4-b]oxazol-6-one (cloxazolam, MT 14-411). There was an inhibition of the DBH-increase during the surgical procedure and an inhibition of the ACTH- and cortisol-secretion before and during surgery as well as a reduction of the insulin antagonizing effect during sympathicoadrenal stimulation. With the exception of a sedative action no other side effects have been observed.
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000009:adverse effects / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D002986:Clinical Trials as Topic; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D056948:Orthognathic Surgical Procedures; D010919:Placebos; D013315:Stress, Psychological / Q000517:prevention & control*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001786:Blood Glucose; D007328:Insulin; D010919:Placebos; D001569:Benzodiazepines; D000324:Adrenocorticotropic Hormone; D004299:Dopamine beta-Hydroxylase; C005522:cloxazolam; D006854:Hydrocortisone
Klinische Untersuchung zur stressabschirmenden Wirkung von Cloxazolam bei kieferchirurgischer Operation im Doppelblindvergleich mit Plazebo.