No evidence for lateral asymmetry of neurotransmitters in post-mortem human brain.
A study of post-mortem human brain was undertaken to establish whether there is any evidence for lateral asymmetry of neurotransmitters. Choline acetyltransferase, glutamic acid decarboxylase, alpha-aminobutyric acid, dopamine and noradrenaline were measured in nine comparable areas from the left and right hemispheres of normal post-mortem human brain. Only nigral GABA showed a left-right difference at a significance level of 5%. These negative post-mortem findings suggest that chemical laterality is unlikely to be an important source of error in human post-mortem studies.
D000368:Aged; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D002795:Choline O-Acetyltransferase / Q000032:analysis; D004298:Dopamine / Q000032:analysis; D005260:Female; D005968:Glutamate Decarboxylase / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D004298:Dopamine; D009638:Norepinephrine