Effects of ethanol, CBD and delta 'THC on proliferation of K-562 cells.
The effect of ethanol and cannabinoids on proliferation of the leukaemic cell line K-562 is described. The effects on the cells were assessed by counts of viable cells and 3H thymidine incorporation. delta 'THC was found to attenuate the proliferation of K-562 cells, the effect being prominent at 10(-4)M. CBD was effective only at high concentrations or after prolonged incubation time. Both drugs were dissolved in 0.3% ethanol solution; ethanol itself caused a biphasic effect, namely a mild increase in K562 proliferation at low concentrations and a marked attenuation at higher concentrations.
D002186:Cannabinoids / Q000494:pharmacology*; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D013759:Dronabinol / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D013936:Thymidine / Q000378:metabolism
D002186:Cannabinoids; D000431:Ethanol; D013759:Dronabinol; D013936:Thymidine