title: The effect of antihypertensive therapy on abnormal leucocyte sodium transport in essential hypertension.
abstract: Sodium transport in leucocytes of essential hypertensives was studied in physiological media. Untreated hypertensives have depressed values for the total and ouabain-sensitive sodium efflux rate constant. Treatment with diuretics abolished this abnormality. These results are compatible with the presence of a circulating inhibitor of sodium transport in essential hypertension.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000584:Amiloride / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001581:Benzothiadiazines; D001794:Blood Pressure; D003971:Diastole; D004232:Diuretics; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000097:blood*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D010042:Ouabain; D000584:Amiloride; D012964:Sodium