[Pharmacological studies of 2-methyl-3(2-phenyl-3-methyl-tetrahydrooxazino)-propiophenone hydrochloride and 1-phenoxycarboxy-1-phenyl-2-methyl-3(2-phenyl-3-methyl-tetrahydrooxazino)-propane hydrochloride compounds].
The authors used the compounds 2-methyl-3)2-phenyl-3-methyl tetrahydroxasino)-propiophenone hydrochloriad (code PsI) and 1-phenoxycarboxy-1-phenyl-2-methyl-3 (2-phenyl-3-methyl-tetrahydroxasino-propan hydrochlorid(code P3) and carried out the following studies: influence of tripamine, corasol and strichnine seizures 1-phenoxycarboxy--1-phenyl-2-methyl--3 (2-phenyl--3-methyl-tetrahydroxasino) propar hydrochlor (Code P8) in white mice, effect on the hypertensive action of reserpine in white rats, investigations on the analeptic action in urethanized cats as well as on the analgetic effect, examined both by the test of "hot plate" and the method of Hendreshot-Forsaith. The examined compounds, administered in a dose of 1/6 of LD50, showed analgetic effect weaker than that of the preparations Morphinum hydrochloricum and Analigin, but their analeptic effect was less manifested that of of corasol. Similar to MAO-inhibitor-oproniazid although in smaller degree the compound PS1 potentiated tripamine seizures and inverted the hypotensive effect of Reserpine into hypertensive.
D000700:Analgesics; D000818:Animals; D000959:Antihypertensive Agents; D002415:Cats; D000697:Central Nervous System Stimulants; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D051379:Mice; D010078:Oxazines / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced
D000700:Analgesics; D000959:Antihypertensive Agents; D000697:Central Nervous System Stimulants; D010078:Oxazines; D011427:Propiophenones
Farmakologichni prouchvaniia na sŭedineniiata 2-metil-3(2-fenil-3-metil-tetrakhidrooksazino)-propiofenol khidrokhlorid i 1-fenoksikarboksi-1-fenil-2-metil-3(2-fenil-3-metil-tetrakhidrooksazino)-propan khidrokhlorid.