Synthesis of some 5-phenylhexahydroazepino[4,5-b]indoles as potential neuroleptic agents.
5-Phenyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (3a) and five derivatives have been prepared and screened for neuroleptic activity. None of the compounds antagonized methamphetamine aggregate toxicity in mice. A number of compounds, including 3a and its 3-methyl derivative 3d, showed activity in the antidepressant screens.
D000085:Acetates / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents; D014150:Antipsychotic Agents / Q000138:chemical synthesis*; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors; D051379:Mice; D051381:Rats
D000085:Acetates; D000927:Anticonvulsants; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D001381:Azepines; D007211:Indoles; D008694:Methamphetamine