[Psychopharmacologic spectrum of melanostatin].
Experiments on cats revealed an emotiotropic action of melanostatin on the original spectrum of emotional reactivity, similar to the effects of L-DOPA and amantadin. The drug does not possess an antidepressant action proper but activates the aggressive-defensive behaviour in experimental reserpine depression and reduces the provocation-induced aggressive behaviour in experimental haloperidol depression. In reserpinized mice, it antagonizes reserpine hypothermia, increases muscle tone and eliminates ptosis. It decreases haloperidol-induced catalepsia. Melanostatin increases the brain level of dopamine and its metabolite, homovanilic acid.
D000374:Aggression / Q000187:drug effects; D000547:Amantadine / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001679:Biogenic Amines / Q000032:analysis; D001923:Brain Chemistry / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced; D002415:Cats; D003863:Depression / Q000139:chemically induced; D004644:Emotions / Q000187:drug effects*; D005334:Fever / Q000139:chemically induced; D006220:Haloperidol / Q000037:antagonists & inhibitors; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors
D001679:Biogenic Amines; D007980:Levodopa; D012110:Reserpine; D009075:MSH Release-Inhibiting Hormone; D000547:Amantadine; D006220:Haloperidol
Issledovanie psikhofarmakologicheskogo spektra melanostatina.