title: Radium needles implant in the treatment of extensive vaginal involvement from cervical carcinoma. A dosimetry appraisal.
abstract: An appraisal of the dosimetry of a modified brachytherapy approach is presented for improving the local control of extensive vaginal involvement from carcinoma of the cervix. This approach incorporates radium needles implant to the vaginal disease in conjunction with the usual routine intracavitary radium application. The aim of the interstitial implant is specifically to supplement the dose to the vaginal disease from the intracavitary application. Our procedure for accomplishing this boost in the dose to the vagina depends on the location, extent and thickness of the vaginal lesion following external beam irradiation of the whole pelvis. An increase of greater than 50 per cent in the dose to the vaginal disease is gained by this combination intracavitary/implant approach which has been used in a variety of cases covering virtually all pertinent stages of cervical carcinoma. Discussion of the dosimetry of example cases is presented to demonstrate the value of combining interstitial and intracavitary therapy for this specific clinical application.
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D005260:Female; D005373:Film Dosimetry; D006801:Humans; D009361:Neoplasm Invasiveness; D011879:Radiotherapy Dosage; D011883:Radium / Q000627:therapeutic use; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*; D014625:Vaginal Neoplasms / Q000532:radiotherapy* / Q000556:secondary
chemical_list: D011883:Radium