Influence of somatostatin on gastric motility and meal absorption in rhesus monkeys, Macaca mulatta.
The effects of somatostatin on gastric motility and nutrient absorption from a mixed meal were evaluated in conscious rhesus monkeys (M. mulatta). Continuous saline or somatostatin (0.8 microgram/kg X min) infusions were carried out prior to and for 2 hr following an intragastric infusion of a complete liquid diet trace-labeled with 3H-3-glucose and 3H-9, 10-triolein. Gastric motility was assessed from recordings of gastric pressure and from extraluminal strain gauges. Intravenous somatostatin did not alter gastric motility or the rate of absorption of the labeled glucose; lipid absorption, however, was markedly impaired.
D000818:Animals; D005502:Food; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D013004:Somatostatin / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism; D014304:Triolein / Q000378:metabolism
D014280:Triglycerides; D014304:Triolein; D013004:Somatostatin; D005947:Glucose