Threshold for the effects of ACTH on blood pressure in sheep.
The time of onset and dose threshold for ACTH induced hypertension was examined in conscious sheep. ACTH 1 microgram/kg per day significantly raised blood pressure. The maximum rise occurred at 2 micrograms/kg per day. The rise in pressure was significant after 8 h of ACTH infusion.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D012756:Sheep; D012964:Sodium / Q000378:metabolism
D000324:Adrenocorticotropic Hormone; D012964:Sodium