Disparate response of encephalomyocarditis virus and MM virus to interferon in JLS-V9R cells.
JLS-V9R cells, a Balb/c mouse bone marrow cell line chronically infected with Rauscher leukemia virus, were treated with mouse interferon and inoculated with several different lytic viruses. Relatively low interferon concentrations protected the cells against Sindbis virus, vesicular stomatitis virus and MM virus. In contrast, encephalomyocarditis virus replication was inhibited by less than 1 log even with an interferon concentration of 1000 U/ml. These findings provide further evidence that interferon-induced antiviral effects are mediated through multiple mechanisms and demonstrate that even viruses which are classified within the same family (MM and encephalomyocarditis virus) can exhibit differential interferon sensitivities.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001853:Bone Marrow; D002460:Cell Line; D004686:Encephalomyocarditis virus / Q000187:drug effects*; D007370:Interferon Type I / Q000494:pharmacology*; D051379:Mice; D010849:Picornaviridae / Q000187:drug effects*; D011925:Rauscher Virus / Q000187:drug effects; D012845:Sindbis Virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007370:Interferon Type I