The biodistribution and metabolic fate of inhaled 11C-octanal in the rat after acute exposure.
Rats were nose exposed to an atmosphere containing 11.4 ppm of 11C-octanal for 2 min. Inhaled octanal was absorbed from the lungs in a biphasic manner and the greatest concentration of octanal occurred in most tissues at 5 min. Tissue activities calculated on the basis of the administered dose and on the radiolabel retained until the animal was killed indicated a redistribution of the radiolabel as metabolic products after 20 min. The labeled carbon was eliminated in a biphasic manner as 11CO2, which accounted for essentially all of the activity lost by the exposed rats.
D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002247:Carbon Isotopes; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D000447:Aldehydes; D002247:Carbon Isotopes; C031639:caprylic aldehyde