[Influence of cimetidine, pentagastrin and somatostatin on prostacyclin synthesis of gastric mucosa in vitro].
In the presence of cimetidine, pentagastrin and somatostatin prostacyclin formation does not differ significantly from the value obtained with the buffer control, whereas cimetidine alone is able to inhibit ADP-induced platelet aggregation in vitro to a small degree. It is concluded that the in vivo action of the drugs if not primarily mediated by prostacyclin.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis*; D005753:Gastric Mucosa / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology
D006146:Guanidines; D011453:Prostaglandins; D013004:Somatostatin; D002927:Cimetidine; D011464:Epoprostenol; D010418:Pentagastrin
Einfluss von Cimetidin, Pentagastrin und Somatostatin auf die Prostazyklinsynthese der Magenschleimhaut in vitro.