A rapid method for the determination of perhexiline in serum using gas-liquid chromatography.
A rapid method for the estimation of perhexiline in serum is presented. The procedure employs a single extraction, and no derivatisation is required. The procedure is linear over the range 0.4-4.0 mg/l, and the limit of detection is 0.09 mg/l. The within- and between-batch coefficients of variation at a concentration of 2.0 mg/l were 2.5 and 4.1%, respectively. Recoveries over the range 0.4-4.0 mg/l produced a mean of 104%. The method is free from interference by other common drugs used in the treatment of angina.
D000319:Adrenergic beta-Antagonists / Q000097:blood; D000889:Anti-Arrhythmia Agents / Q000097:blood; D002849:Chromatography, Gas / Q000379:methods; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010480:Perhexiline / Q000097:blood*; D010880:Piperidines / Q000097:blood*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D010880:Piperidines; D010480:Perhexiline