No inhibition of corticotrophin (ACTH)-hypersecretion in adrenal insufficiency by somatostatin.
Somatostatin (250 micrograms as a bolus iv and 250 micrograms as a 1 h infusion) was administered to 6 patients with primary adrenal insufficiency (Addison's disease). The fall in plasma ACTH during the infusion period ranged between 0-30% with a mean reduction of 11.2 +/- 11.6%. These findings suggest that with the method employed, somatostatin is not an inhibitor of ACTH secretion in a condition in which glucocorticoids are lacking.
D000224:Addison Disease / Q000097:blood / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000328:Adult; D000368:Aged; D006801:Humans; D008875:Middle Aged; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin; D000324:Adrenocorticotropic Hormone