Normal and disturbed motility pattern in the duodenum of man. The effect of l-hyoscyamine, trimipramine and ranitidine on the maximal pressure waves.
Eight healthy subjects were examined in random order with an electronic capsule transducer, two capsules being mounted 8 cm from each other in the duodenum. At least two grade III maximal pressure waves were recorded following 0.6 mg l-hyoscyamine (Hässle), 50 mg trimipramine (Surmontil, Rhone Poulenc) or 150 mg ranitidine (Glaxo-Nyegaard & Co.) perorally. A significant prolonged cyclic length (Fig. 1) was observed on the day when l-hyoscyamine was given when compared to results on the day when placebo was given (Table I). No significant differences were observed between placebo and the other drugs given.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D001655:Bile Reflux; D003984:Dibenzazepines / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects*; D005663:Furans / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D011899:Ranitidine; D014160:Transducers, Pressure; D014299:Trimipramine / Q000494:pharmacology*
D003984:Dibenzazepines; D005663:Furans; D006635:Histamine H2 Antagonists; D014299:Trimipramine; D001285:Atropine; D011899:Ranitidine