The effects of the optical isomers of propranolol on functional refractory period in rat isolated myocardium.
The two optical isomers of propranolol caused a concentration-dependent increase in functional refractory period of the rat isolated left atrium. In this property the isomers were equipotent. Naradrenaline (1 X 10-(7) M) decreased the functional refractory period. This effect was completely reversed by (-)-propranolol. The (+)-isomer was much less potent than (-)-propranolol in antagonizing the effects of noradrenaline on functional refractory period.
D000818:Animals; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D011433:Propranolol; D009638:Norepinephrine