Immunohistological studies of medullary thyroid carcinoma and C cell hyperplasia.
A series of 59 thyroidal C cell neoplasms was studied by immunoperoxidase histology. These neoplasms included human medullary thyroid carcinoma and C cell hyperplasia and rat medullary thyroid carcinoma. In addition to calcitonin, the tumors were studied by immunohistology for the presence of beta-endorphin, ACTH, and somatostain. All but one of the neoplasms were positive for calcitonin, 25 of 31 were positive for beta-endorphin, 12 of 18 were positive for ACTH, and 9 of 19 were positive for somatostatin immunoreactivity. Many tissues contained all 4 peptides, and in some sections these peptide immunoreactivities seemed to be present in the same cells. These studies suggest that there is a relationship in these tumors among the 4 peptides studied, but the basis of this relationship is not clear.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002116:Calcitonin / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D051381:Rats; D013004:Somatostatin / Q000378:metabolism; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000378:metabolism*
D004723:Endorphins; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D002116:Calcitonin