Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer. Binding of bile salts to dietary residues.
The binding of glycocholic and glycochenodeoxycholic acids to dried defatted residues of homogenized diets consumed by four dietary groups has been measured. The four groups were true vegetarian Seventh-day Adventists (SDA), lacto-ovo vegetarian SDA, nonvegetarian SDA, and the general population. Glycocholic acid was bound to the same extent (7 to 9%) by all four dietary residues. The true vegetarian SDA residues bound significantly more glycochenodeoxycholic acid than those of either lacto-ovo vegetarian SDA (p less than 0.001) or nonvegetarian SDA (p less than 0.001). The general population residue bound significantly more glycochenodeoxycholic acid than did those of nonvegetarian SDA (p less than 0.001). Binding of glycochenodeoxycholic acid was significantly correlated with dietary neutral detergent fiber (p less than 0.001), hemicellulose (p less than 0.01) and cellulose (p = 0.01). There was no correlation between the binding of glycochenodeoxycholic acid and dietary lignin, pectin, or cutin.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001647:Bile Acids and Salts / Q000378:metabolism*; D014676:Diet, Vegetarian; D004043:Dietary Fiber / Q000378:metabolism*; D005260:Female; D005999:Glycochenodeoxycholic Acid / Q000378:metabolism; D006000:Glycocholic Acid / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D001647:Bile Acids and Salts; D004043:Dietary Fiber; D005999:Glycochenodeoxycholic Acid; D006000:Glycocholic Acid