title: Combined antihypertensive therapy: vasodilatation using prazosin in combination with beta-adrenoceptor blockers and diuretics.
abstract: An open study was carried out in 20 hypertensive patients, who had inadequate blood pressure control with beta-adrenoceptor blocking drugs and diuretics, to investigate the effects of adding prazosin to their existing treatment regimen. Patients received a mean daily dose of prazosin of 8.7 +/- 4.4 mg over a period of 12 weeks. The results showed that there was a significant reduction in systolic and diastolic blood pressures in the resting position. Only a few side-effects were reported and these occurred during the first 4 weeks whilst prazosin dosage was being adjusted. Weight increase, however, was noted in all but 4 of the patients. It is suggested that this may have been due partly to fluid retention, even though the majority were receiving diuretics, or possibly to changed carbohydrate-insulin metabolism.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000009:adverse effects / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D004232:Diuretics; D011799:Quinazolines; D011224:Prazosin