[The influence of a beta-adrenergic receptor blocking drug and a calcium antagonist on heart function in normal subjects (author's transl)].
In 13 healthy volunteers, ergometric examinations in the supine position after intake of 2 x 40 mg/d (-)-1-(tert.-butyl-amino)-3-(o-cyclopentylphenoxy)-2-propanol (penbutolol, Betapressin), a new beta-adrenergic receptor blocking substance, or 3 x 60 mg/d N-(3,3-diphenylpropyl)-alpha-methyl-phenethylamine (prenylamine, Segontin) showed no alteration of the exercise tolerance compared to controls. Also there was a significant decrease of heart rate and systolic pressure and an increase of the maximal heart volume at rest and during exercise after intake of the beta-adrenergic receptor blocking drug. The increased heart volume decreased slightly during exercise as was observed in the controls. Diastolic blood pressure increased during exercise. After intake of the calcium antagonist prenylamine there was a slight decrease of heart rate and systolic pressure and an increase of the maximal heart volume. The increased heart volume decreased again during exercise as well as the diastolic pressure. Therefore the sparing of myocardial oxygen uptake can be explained by the decrease of heart rate and systolic pressure during beta-adrenergic blockade and during prenylamine because of an additional decreased afterload resulting from decreased diastolic pressure. Furthermore in the case of both drugs, the increased myocardial oxygen uptake caused by increased heart volume, will be decreased during exercise.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010394:Penbutolol / Q000494:pharmacology; D011299:Prenylamine / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D010394:Penbutolol; D011299:Prenylamine
Einfluss eines beta-Rezeptorenblockers und Calcium-Antagonisten auf die Herzfunktion von Normalpersonen.