title: Do vascular clones determine developmental patterns?
abstract: It is postulated that endothelial (and possibly other) cells are arranged in monoclonal zones, each of which occupies an accurately predetermined site in the cardiovascular system. The clones impose detailed developmental patterns on the vascular tree itself and provide positional information relevant to the morphogenesis of surrounding tissues--for example, clones in the dermis regulate the behaviour of epidermal melanocytes.
mesh_terms: D002319:Cardiovascular System / Q000166:cytology / Q000196:embryology*; D002999:Clone Cells / Q000166:cytology; D004727:Endothelium / Q000166:cytology / Q000196:embryology; D006801:Humans; D008544:Melanocytes / Q000166:cytology; D008954:Models, Biological; D008957:Models, Genetic; D009024:Morphogenesis; D009030:Mosaicism; D012867:Skin / Q000196:embryology; D012880:Skin Pigmentation