Arylsulfatases A and B in leukocytes: a comparative statistical study of late infantile and juvenile forms of metachromatic leukodystrophy and controls.
We report a statistical study on the level of aryl-sulfatases A and B in leukocytes of 106 controls, 19 cases of metachromatic leukodystrophy (MLD) infantile and juvenile forms and 25 obligate heterozygotes for MLD. Arylsulfatase A has been found to be similarly deficient in patients of the two forms. Half of the mean of the controls have been found in both types for heterozygotes. Arylsulfatase B (ASB) is slightly higher than normal in late infantile MLD although it is not statistically significant. In the 5 cases of the juvenile forms that were examined, ASB was found to be significantly reduced. This enzyme may play a role in relation to the onset of the disease.
D000293:Adolescent; D000328:Adult; D002553:Cerebroside-Sulfatase / Q000097:blood* / Q000172:deficiency; D002648:Child; D002675:Child, Preschool; D002803:Chondro-4-Sulfatase / Q000097:blood* / Q000172:deficiency; D006579:Heterozygote; D006801:Humans; D007223:Infant; D007962:Leukocytes / Q000201:enzymology*; D007966:Leukodystrophy, Metachromatic / Q000201:enzymology* / Q000235:genetics; D013429:Sulfatases / Q000097:blood*
D013429:Sulfatases; D002553:Cerebroside-Sulfatase; D002803:Chondro-4-Sulfatase