Immune-complex inhibition of lymphocyte Fc gamma-receptors in primary biliary cirrhosis: a possible immunomodulatory mechanism.
20 patients with primary biliary cirrhosis (PBC) had circulating IgG-containing immune complexes. These complexes bind to lymphocyte Fc gamma-receptors in vitro; there was also evidence for in-vivo binding. Such in-vivo binding to T and K lymphocytes may exert an immunomodulatory effect on these cells, and may also explain some of the serological and cellular abnormalities in PBC.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex; D001323:Autoantibodies / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008105:Liver Cirrhosis, Biliary / Q000209:etiology / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology*; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007074:Immunoglobulin G; D011961:Receptors, Fc