Functions of central nervous system neurotransmitters in regulation of growth hormone secretion.
Pituitary growth hormone (GH) secretion is regulated by two hypothalamic factors: somatostatin, a characterized tetradecapeptide, which inhibits secretion, and GH-releasing factor, unidentified, which stimulates secretion. Biogenic amines, including norepinephrine, dopamine, serotonin, acetylcholine, and gamma-aminobutyric acid have excitatory or inhibitory effects at brain sites to modulate hypothalamic control. alpha-Adrenergic mechanisms have been shown to be of particular importance in the regulation of physiologic GH secretion, which is characterized by episodic surges of release.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology; D006632:Histamine / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D010902:Pituitary Gland / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology; D013004:Somatostatin / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018377:Neurotransmitter Agents; D012701:Serotonin; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D006632:Histamine; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D000109:Acetylcholine