Dual action of somatostatin upon peristalsis in the guinea pig isolated ileum.
Peristalsis in the guinea pig isolated ileum usually consists of alternating periods of activity and peristalsis-free intervals (PFIs). When PFIs were shorter than, on an average, 5 min, somatostatin at 10(-9) or 10(-8) M prolonged subsequent PFIs. By contrast, when PFIs were longer than 5 min. somatostatin shortened subsequent PFIs. No evidence could be found for an interaction of somatostatin with opioid mechanisms. The present work demonstrates that the action of a substance upon intestinal peristalsis in vitro may depend, at least in the case of somatostatin, upon the functional state of the isolated intestinal segment.
D000818:Animals; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects*; D013004:Somatostatin / Q000494:pharmacology*
D009270:Naloxone; D013004:Somatostatin