Inhibition of isolation-induced changes in aminergic transmission by chronic lithium treatment.
Social isolation of mice leads to changes in aminergic transmission systems. After 6 weeks of isolation, an increase of apomorphine-stimulated climbing behavior is seen, reflecting an isolation-induced dopaminergic supersensitivity. After 1-3 weeks of isolation, a decrease of clonidine sedation is detectable, suggesting the development of noradrenergic alpha 2-receptor subsensitivity. The isolation-induced changes of both drug effects are prevented by lithium given over the time of isolation.
D000818:Animals; D001058:Apomorphine; D001679:Biogenic Amines / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012934:Social Isolation; D009435:Synaptic Transmission / Q000187:drug effects*
D001679:Biogenic Amines; D008094:Lithium; D003000:Clonidine; D001058:Apomorphine