title: Mechanisms of tolerance and dependence: an overview.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D004361:Drug Tolerance; D004723:Endorphins / Q000502:physiology; D006605:Hibernation; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D066298:In Vitro Techniques; D009294:Narcotics / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000502:physiology; D011957:Receptors, Opioid / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology
chemical_list: D004723:Endorphins; D009294:Narcotics; D009419:Nerve Tissue Proteins; D011957:Receptors, Opioid; D000262:Adenylyl Cyclases