Could binding sites of a receptor be "seen"? A great challenge to picosecond spectroscopy.
It is shown that the combined picosecond infrared and Raman spectroscopy, developed in investigations of vibrational energy transfer in molecular liquids and in matrix isolated molecules could be adapted to study complexes between small molecules and biological receptors. It should be possible to determine the atomic structure of the receptor binding sites by the method proposed and perhaps even information could be obtained about the structural changes which these sites undergo on binding.
D001665:Binding Sites; D008024:Ligands; D011487:Protein Conformation; D011956:Receptors, Cell Surface; D013059:Spectrum Analysis, Raman / Q000379:methods; D014732:Vibration
D008024:Ligands; D011956:Receptors, Cell Surface