The pattern of D-galactosamine-induced hepatocellular injury modified by simultaneous application of D (--)-fructose.
As shown by light and electron microscopy, and by biochemical investigation, D-galactosamine-induced hepatocellular injury in the rat can be prevented by giving fructose simultaneously. However, when injected 3 h after D-galactosamine, fructose has no protective effect. It is suggested that rapid fructose phosphorylation, with the consequent marked depression of the hepatocellular ATP pool, inhibits the more prolonged D-galactosamine phosphorylation and with it the injurious effects of D-galactosamine metabolism.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D005632:Fructose; D005688:Galactosamine; D008099:Liver / Q000648:ultrastructure; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005632:Fructose; D005688:Galactosamine