[Membranes properties of granulocytes in Job's-Syndrome with E. coli-septicemia (author's transl)].
Since the age of nine weeks a red haired girl suffered from purulent dermatitis and recurrent, systemic E. coli infections. She had an excessive hyperimmunoglobulinemia E, as well as impaired granulocyte adherence and chemotaxis. Though a sepsis was evident, the granulocytes exhibited a random FITC-Concanavalin A fluorescence. In spite of intensive treatment with various antibiotics and several granulocyte transfusions the child died at the age of 2 years and 11 months. As shown by the FITC-Concanavalin A distribution, the hyperimmunoglobulinemia E may have caused a decreased membrane fluidity causing the impaired adherence and chemotaxis. This could explain the pathophysiology of the Job's Syndrome.
D002462:Cell Membrane / Q000276:immunology*; D002633:Chemotaxis; D002675:Child, Preschool; D003872:Dermatitis / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology*; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis; D007223:Infant; D007589:Job Syndrome / Q000276:immunology*; D007957:Leukocyte Adherence Inhibition Test; D010585:Phagocyte Bactericidal Dysfunction / Q000276:immunology*; D018805:Sepsis / Q000276:immunology*
D007073:Immunoglobulin E
Membraneigenschaften der granulozyten bei einem Hiob-Syndrom mit E. coli-Sepsis.