Effect of queuine on protein biosynthesis in mammalian cells.
Administration of queuine into intact cells has an affected protein biosynthesis in vivo. In C3H2K mouse kidney cells, synthesis of a protein having a molecular weight of 45,000 was prevented by addition of queuine into the culture medium. In the case of SA-1 cells, which are variant cells of mouse mammary tumor cells, a protein whose molecular weight was 95,000 and located in the cytosol of its cells was changed to a more basic protein by administration of queuine.
D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008970:Molecular Weight; D014176:Protein Biosynthesis; D011506:Proteins / Q000302:isolation & purification; D013539:Simian virus 40 / Q000235:genetics
D011506:Proteins; D006147:Guanine; C019549:queuine