Effects of changes in dietary sodium intake on normotensive subjects with and without a genetic predisposition to essential hypertension.
Twenty-two young normotensive male subjects, 12 with an established family history of essential hypertension, were put on a low-followed by a high-sodium diet. Plasma from each dietary period was tested for inhibitory activity on Na-K-ATPase using three different techniques: measurement of 22Na efflux rate, measurement of 3H ouabain binding characteristics and a bioluminescent adenosine triphosphate assay. The high-sodium diet was associated with a diminished ouabain-sensitive sodium efflux rate constant in the whole group; however, no circulating inhibitor could be detected in the plasma. Those with and those without a family history of essential hypertension were indistinguishable. The results suggest that young normotensive individuals with a genetic predisposition to essential hypertension do not produce a circulating inhibitor of sodium-potassium adenosine triphosphatase (Na-K-ATPase) in response to a high-sodium challenge.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000818:Animals; D001681:Biological Assay; D001692:Biological Transport / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D004198:Disease Susceptibility; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D007668:Kidney / Q000201:enzymology; D008163:Luminescent Measurements; D008297:Male; D010042:Ouabain / Q000097:blood; D012964:Sodium / Q000008:administration & dosage* / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013997:Time Factors
D010042:Ouabain; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase