Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glucosylated proteins.
Plasma proteins glucosylated in vitro were injected repeatedly into 7 mice. A group of 4 was given multiple injections of non-glucosylated plasma proteins and another 10 were untreated. 5 of 7 mice given glucosylated proteins had glomerular-basement-membrane thickening on electron microscopical examination. This feature is characteristic of human and experimental diabetic renal disease. These results suggest that there may be a link between plasma-protein glucosylation and diabetic nephropathy.
D000818:Animals; D001485:Basement Membrane / Q000098:blood supply / Q000187:drug effects / Q000648:ultrastructure; D001786:Blood Glucose / Q000032:analysis*; D002196:Capillaries / Q000648:ultrastructure; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D003928:Diabetic Nephropathies / Q000139:chemically induced* / Q000378:metabolism; D006027:Glycosides / Q000008:administration & dosage*; D006441:Hemoglobin A / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007267:Injections; D007678:Kidney Glomerulus / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C
D001786:Blood Glucose; D006027:Glycosides; D006441:Hemoglobin A