Role of gastrointestinal transit in the delay of absorption by viscous fibre (guar).
The influence of guar gum on gastric emptying of liquids in healthy volunteers and on mouth-to-caecum transit time in controls and partially gastrectomized patients has been studied. Together with a flattening effect on blood glucose profiles after a liquid glucose load, guar significantly delays mouth-to-caecum transit time both in healthy controls and partially gastrectomized patients. The retardation of transit is not explicable by a delay in gastric emptying, as can be shown by means of an isotope technique. Only in "quick starters' was a delay in initial gastric emptying observed. The exponential phase of gastric emptying remained unaffected. Moreover, it is shown that the prolongation of mouth-to-caecum transit time is not mediated by factors operating at the level of the pyloricantral region. Delayed small-bowel passage by guar might modulate absorption of glucose by increasing the unstirred layer resistance and, in the non-steady state, by limiting the absorptive area initially covered by a bolus.
D000328:Adult; D000368:Aged; D004043:Dietary Fiber / Q000494:pharmacology*; D004068:Digestive System Physiological Phenomena; D005685:Galactans / Q000378:metabolism / Q000494:pharmacology*; D005743:Gastrectomy; D005746:Gastric Emptying / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008351:Mannans / Q000378:metabolism / Q000494:pharmacology*; D008875:Middle Aged; D053149:Plant Gums; D014783:Viscosity
D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; C007894:guar gum; D005947:Glucose