Motilin-independent ectopic fronts of the interdigestive myoelectric complex in dogs.
We have studied in four conscious dogs the relationship between circulating concentrations of motilin and the activity front (phase III) of the interdigestive myoelectric complex. During fasting, cyclic peaks of motilin secretion were concomitant in every instance with the initiation of activity fronts that began in the stomach or duodenum. When somatostatin was administered at doses of 5, 2.5, or 0.625 microgram x kg-1 x h-1 for 3 h, motilin concentrations were stabilized at lowered levels and no activity fronts occurred in the duodenum. Somatostatin also inhibited the stimulatory effects of exogenous motilin on the entire small intestine. During somatostatin infusion, however, ectopic fronts began in the jejunum and were propagated to the cecum despite low motilin concentration. After a 100-g meat meal, the cyclic increase of motilin was interrupted and no activity fronts were observed in the duodenum, but ectopic fronts started lower in the small intestine. Our study supports the hypothesis that motilin induces activity fronts in the canine duodenum, but it shows that ectopic fronts are not controlled by motilin.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000502:physiology; D005260:Female; D005768:Gastrointestinal Hormones / Q000097:blood*; D005769:Gastrointestinal Motility / Q000187:drug effects; D009037:Motilin / Q000097:blood* / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology; D013270:Stomach / Q000502:physiology
D005768:Gastrointestinal Hormones; D013004:Somatostatin; D009037:Motilin