[Hemodynamic and renal effects of mezaton and izadrin].
The possibility of stimulating the beta-adrenoreceptors of the heart and vessels with mesaton (phenylephrine hydrochloride) was demonstrated in experiments on anesthesized dogs. In sharp hemodynamic shifts, a close functional dependence was revealed between the changes in the tonus of the resistant vessels, the blood renin activity, and the renal excretion of electrolytes and water. It is suggested that there is synchronous regulation of changes in the vascular tonus and the urination rate, which is effected through the renin-angiotensin system with adaptation of the system of intravascular circulation to the altering conditions of functioning.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D010656:Phenylephrine / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D010656:Phenylephrine; D007545:Isoproterenol
Gemodinamicheskie i pochechnye éffekty mezatona i izadrina.