[Synthesis and biological activity of substituted 2-(4-imidazolyl)ethylamines].
The synthesis of 2-(4-imidazolyl)ethylamines with hydrocarbon substituents on the heterocyclic ring or on the side-chain, from 2-acylbutyrrolactones (V) or from similar ester-type open structures (VII) is described in this paper. In particular, the results already obtained, show that the scheme given for the preparation of 2-(5-methyl-4-imidazolyl)ethylamines can be rendered general, by suitable variations correlated more with side-chain branching, than with the nature of the heterocyclic ring substituents. Synthetized imidazolyethylamines have been preliminarily tested for their properties towards H2 receptors and, secondly, towards H1 receptors.
D000818:Animals; D002415:Cats; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis*; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques
D005021:Ethylamines; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D007093:Imidazoles
Sintesi ed attività biologiche di 2-(4-imidazolil)etilamine im sostituite.