The antihypertensive action of beta-adrenoceptor blocking agents.
The fall in blood pressure after the induction of beta-blockade occurs approximately 3 hours after the fall in cardiac output, heart rate and plasma renin activity has occurred. None of the known pharmacological actions of these agents can directly account for the fall in pressure. Further work is required to determine whether the fall in cardiac output is essential or whether these agents affect renal handling of sodium. Studies are also needed of baroceptor function as blood pressure falls.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents