Lipoproteins and the regulation of adrenal steroidogenesis.
ACTH has both short-term (acute) and long-term (chronic) effects to regulate steroid hormone biosynthesis in the adrenal cortex. The acute action of ACTH involves the mobilization of cholesterol and its binding to cytochrome P-450scc. The long-term action of ACTH involves the regulation of synthesis of the various enzymes involved in steroidogenesis. Evidence is presented that cholesterol may have a role to play in this regulatory process as it does in the short-term action of ACTH, consistent with the concept that substrates of specific forms of cytochrome P-450 are frequently able to regulate the synthesis of these specific forms.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000325:Adrenodoxin / Q000096:biosynthesis; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000494:pharmacology; D051381:Rats; D013256:Steroids / Q000096:biosynthesis*
D008074:Lipoproteins; D008077:Lipoproteins, LDL; D013256:Steroids; D000325:Adrenodoxin; D000324:Adrenocorticotropic Hormone; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol