Relative uptake of low- and high-osmolality contrast media in CT of brain tumors.
The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30 and 45 minutes was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during the infusion, and the magnitude was the same for both agents. Per gram of iodine infused, blood iodine was 12.4% higher with ioxaglate than iothalamate. The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors.
D000818:Animals; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000662:veterinary; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000662:veterinary; D003287:Contrast Media; D004283:Dog Diseases / Q000000981:diagnostic imaging; D004285:Dogs; D007482:Iothalamate Meglumine; D007485:Ioxaglic Acid; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging; D008579:Meningioma / Q000000981:diagnostic imaging / Q000662:veterinary; D009373:Neoplasms, Germ Cell and Embryonal / Q000000981:diagnostic imaging / Q000662:veterinary; D009994:Osmolar Concentration; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007482:Iothalamate Meglumine; D007485:Ioxaglic Acid