Successful allogeneic bone marrow transplantation for three children with acute nonlymphocytic leukemia.
Three children with acute nonlymphocytic leukemia in first remission were given cyclophosphamide (60 mg/kg on each of 2 days), fractionated total-body irradiation (total 12 Gy, six fractions), and a marrow transplant from an HLA-identical, mixed lymphocyte culture-negative sibling. All three patients are alive in a leukemia-free state 12 to 25 mo after transplantation. There were very few complication, other than mild graft-versus-host disease that developed in two patients. No interstitial pneumonitis and no serious infections have occurred. Long-term disease-free survival is expected in these patients.
D000208:Acute Disease; D000293:Adolescent; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000150:complications; D006566:Herpesviridae Infections / Q000209:etiology; D006801:Humans; D007938:Leukemia / Q000401:mortality / Q000628:therapy*; D011658:Pulmonary Fibrosis / Q000209:etiology; D014184:Transplantation, Homologous