Differential reversal by scopolamine and THIP of the antistereotypic and cataleptic effects of neuroleptics.
Scopolamine reversed the neuroleptic-induced catalepsy and neuroleptic blockade of amphetamine-induced stereotypies in rats. The effect on catalepsy was the most pronounced. Butyrophenones were mainly sensitive to scopolamine reversal whereas the thioxanthenes cis-Z-flupentixol and piflutixol were not significantly influenced. THIP did not change the effects of cis-Z-flupentixol, fluphenazine and haloperidol. The relevance of these findings for the use of stereotypy and catalepsy tests as screening for antiscizophrenic and extrapyramidal side-effects, respectively, is discussed.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D014150:Antipsychotic Agents; D007555:Isoxazoles; D010080:Oxazoles; D000661:Amphetamine; D012601:Scopolamine; C015542:gaboxadol