Studies of circulation and acid-base balance in pregnant sheep: I. The effect of aminophylline infusion.
The maternal and fetal effects of aminophylline on hemodynamics and acid-base and blood gas balances were evaluated by 11 infusions to four chronically catheterized sheep at 114-142 days' gestation. Maternal and fetal arterial blood samples were drawn for baseline determination at 15-minute intervals. Mean maternal and fetal pH levels and heart rates increased significantly. Respiratory alkalosis was indicated by a concomitant fall in mean maternal carbon dioxide pressure. We conclude that aminophylline infusion (5.6 mg/kg of body weight/15 min) to pregnant sheep may cause maternal and fetal tachycardia and alkalosis, with a possible increase in uterine blood flow, but no changes in fetal blood gas status or blood pressure.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D014599:Uterus / Q000098:blood supply
D002245:Carbon Dioxide; D000628:Aminophylline; D010100:Oxygen