The influence of some brainstem noradrenergic structures on the stress-induced secretion of adrenocorticotrophic hormone (ACTH).
The intensity of the stress-induced secretion of ACTH was investigated in rats after electric lesions of Locus coeruleus and Nucleus subcoeruleus. Plasma ACTH was estimated radioimmunologically. Stress-induced ACTH release in lesioned rats was found to be significantly higher as compared with sham operated and intact animals. Some aspects of the participation of brainstem ascending noradrenergic pathways in neuroendocrine regulation are discussed.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D008125:Locus Coeruleus / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D000324:Adrenocorticotropic Hormone; D009638:Norepinephrine