title: Bactericidal activity of continuously changing cefotaxime concentrations in human blood.
abstract: Activity of cefotaxime against Escherichia coli and Klebsiella pneumoniae was investigated in a model producing in-vitro simulation of pharmacokinetic parameters. Bacteria were suspended in fresh human blood in which the cefotaxime concentration rose slowly from zero to a mean peak of 9.62 mg/l (+/- 1.95) at a mean of 2.8 h (+/- 0.44) and dropped to below detection level of less than 1 mg/l at 12 h. Under these conditions cefotaxime was rapidly bactericidal. Only one out of the six strains tested had recovered from the toxic effect of cefotaxime after 24 h.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D001770:Blood Bactericidal Activity / Q000187:drug effects; D002439:Cefotaxime / Q000097:blood* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans
chemical_list: D002439:Cefotaxime