Portal somatostatin responds to intragastric glucose: effects of streptozotocin diabetes.
Changes in somatostatin levels in portal response to intragastric glucose loading were examined in normal controls and streptozotocin diabetic rats for one week duration. The mean (+/- SEM) basal level of somatostatin was more significantly elevated in diabetic rats (401 +/- 62 pg/ml) than in controls (171 +/- 13 pg/ml). However, no significant difference in somatostatin concentrations 30 min after glucose loading was found between diabetic and control animals (587 +/- 113 vs. 443 +/- 47 pg/ml). Glucose loading caused a significant elevation of somatostatin in controls, but not in diabetic rats. These results suggest a physiologic role of somatostatin in nutrient homeostasis, and that abnormalities in D cell function are present in streptozotocin diabetes of short duration.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D011169:Portal Vein; D051381:Rats; D013004:Somatostatin / Q000097:blood*; D013270:Stomach; D013311:Streptozocin
D001786:Blood Glucose; D007328:Insulin; D013004:Somatostatin; D013311:Streptozocin; D005947:Glucose