[Age and the role of certain mediators in the sensitivity of animals to hyperbaric oxygenation].
Dynamics of biologically active brain peptides: N-acetyl-1-aspartat-1-glutamat (NAAG) and homocarnosine (gamma-aminobutyric-1-histidine), aminoacids and their derivatives GABA, histidine and histamine, in the blood of rats and rabbits of different age under hyperoxia was studied. Exposure of animals to 4 atm of oxygen considerably decreased NAA and NAAG contents in the brain of 21 and 30-day old rats and induced the 85% and 47% decrease of homocarnosine and GABA contents respectively in the brain of 30-day old rabbits. Brain histidine and blood histamine contents increased in 14, 21 and 30-day old rabbits.
D000367:Age Factors; D000818:Animals; D001923:Brain Chemistry; D002336:Carnosine / Q000031:analogs & derivatives / Q000032:analysis; D004151:Dipeptides / Q000032:analysis*; D006632:Histamine / Q000097:blood; D006639:Histidine / Q000032:analysis; D006931:Hyperbaric Oxygenation; D018377:Neurotransmitter Agents / Q000032:analysis*; D011817:Rabbits; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D004151:Dipeptides; D018377:Neurotransmitter Agents; C027172:isospaglumic acid; C005038:homocarnosine; D006639:Histidine; D005680:gamma-Aminobutyric Acid; D006632:Histamine; D002336:Carnosine
Rol' nekotorykh mediatorov v vozrastnoĭ chuvstvitel'nosti zhivotnykh k giperbaricheskoĭ oksigenatsii.