title: [Vigilance and beta blockade. The influence of the beta blocker atenolol and other substances on the reaction time of the visual system].
abstract: Visual reaction times as a measure of vigilance and of the psycho-physiological condition of subjects was determined after combined physical and mental stress to examine beta-blocker influence. Using the technique of electrooculography 40 subjects aged 25,7 +/- 6 with a mean blood pressure to 126/79 mmHg were measured in a double-blind cross-over design after application of placebo or 50 mg of atenolol (Tenormin) for 3 days. Visual reaction time was defined as the time between display of a peripheral light signal and the start of the eye movement that shifts the direction of gaze from the reference point to the stimulus. The results of the study show, that under these experimental conditions there is a positive effect of beta-blocker medication on vigilance. Findings of other authors are discussed. To prove the sensitivity of the test method in a preliminary study, the effects of the well-described drugs fenetyllinhydrochloride, diazepam, oxazepam and alcohol on visual reaction time were investigated.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000662:Amphetamines / Q000627:therapeutic use; D001262:Atenolol / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects*; D003975:Diazepam / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010076:Oxazepam / Q000627:therapeutic use; D011412:Propanolamines / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D013806:Theophylline / Q000031:analogs & derivatives / Q000627:therapeutic use; D014796:Visual Perception / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D000662:Amphetamines; D011412:Propanolamines; D001262:Atenolol; D010076:Oxazepam; D013806:Theophylline; D003975:Diazepam; C004518:fenethylline
vernacular_title: Vigilanz und Beta-Blockade. Einfluss des Beta-Blockers Atenolol und anderer Substanzen auf die Reaktionszeit des visuellen Systems.