The temperature-sensitive defect in polyoma virus P155 mutant.
P155 is a temperature-sensitive mutant of polyoma virus that transforms normally, but replicates poorly, under restrictive conditions (Eckhart, 1969, 1975). We have observed that the temperature-sensitive character of P155 maps within the portion of the viral DNA coding exclusively for large T antigen, a viral gene product which is thermolabile in P155-infected cells. The phenotype of P155 may indicate that large T antigen fulfills different functions in virus replications and in cell transformation.
D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000032:analysis; D002874:Chromosome Mapping; D009154:Mutation; D011120:Polyomavirus / Q000235:genetics*; D013696:Temperature; D014764:Viral Proteins / Q000032:analysis; D014779:Virus Replication
D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D014764:Viral Proteins