Metabolism of arildone, an antiviral agent, in laboratory animals.
After arildone administration, four compounds were identified in the excreta of laboratory animals: unchanged drug, arildone; the O-desmethyl metabolite, 4-[6-(2-chloro-4-hydroxy)phenoxy]hexyl-3,5-heptanedione; the sulfate ester of 2-chloro-4-methoxyphenol; and a labile conjugate of chlorohydroquinone, tentatively characterized as the sulfate ester. The concentrations of each of these were determined in the urine and/or plasma of rats, dogs, and mice after administration of 14C-arildone.
D000818:Animals; D000830:Animals, Laboratory; D000998:Antiviral Agents / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D007659:Ketones / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000998:Antiviral Agents; D007659:Ketones; C020706:arildone