Acute uptake and chronic retention of infarct avid myocardial-seeking agents: 99Tcm-pyrophosphate and 125I-phenylphosphate.
The concentration of 125I-phenylphosphate (I phi PA), a long-lived bone-seeking radio-pharmaceutical (T1/2 biol = 962 days) that localizes in acute infarction (MI), was studied in 30 rats after ligation of the anterior descending coronary artery. At 23 h postMI, I phi PA was given intravenously to all animals, and five of this group received 99Tcm-pyrophosphate (99Tcm-pyro) intravenously. These five rats were sacrificed 2 h later and the content of I phi PA and 99Tcm-pyro activities was determined for normal and infarcted (INF) heart segments. There is a zone of INF that contains residual I phi PA which also concentrates 99Tcm-pyro consistently after MI. This zone may represent jeopardized myocardium which has not undergone complete necrosis.
D000818:Animals; D003331:Coronary Vessels / Q000601:surgery; D011756:Diphosphates; D007457:Iodine Radioisotopes; D008026:Ligation; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000209:etiology; D009943:Organophosphorus Compounds; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate; D013997:Time Factors
D011756:Diphosphates; D007457:Iodine Radioisotopes; D009943:Organophosphorus Compounds; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; C023604:phenylphosphonic acid