title: [Orientotoxin--a new presynaptic neurotoxin from the venom of the giant hornet Vespa orientalis].
abstract: Orientotoxin, a novel presynaptically acting neurotoxin from the venom of giant hornet Vespa orientalis, has been isolated by gel filtration and ion exchange chromatography and characterized. The toxin has a molecular mass of 18,000. Highly purified preparations of orientotoxin possessed clearly manifested lysophospholipase activity and can block both induced and spontaneous release of neurotransmitter from the presynaptic nerve membrane.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001001:Anura; D001514:Bee Venoms / Q000032:analysis* / Q000302:isolation & purification*; D002850:Chromatography, Gel; D066298:In Vitro Techniques; D008564:Membrane Potentials; D009469:Neuromuscular Junction / Q000502:physiology; D009498:Neurotoxins / Q000302:isolation & purification* / Q000494:pharmacology; D017981:Receptors, Neurotransmitter / Q000502:physiology; D014862:Wasp Venoms / Q000032:analysis* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D001514:Bee Venoms; D009498:Neurotoxins; D017981:Receptors, Neurotransmitter; D014862:Wasp Venoms; C042190:orientotoxin
vernacular_title: Orientotoksin--novyĭ presinapticheskiĭ neĭrotoksin iz iada bol'shogo shershnia Vespa orientalis.