Choline acetyltransferase activity and [3H]quinuclidinylbenzilate binding in brains of scrapie-infected hamsters.
Choline acetyltransferase (ChAT) activity and [3H]quinuclidinylbenzilate binding were studied in the brain of scrapie-infected hamsters and sham inoculated controls. Although scrapie-infected hamsters showed no reduction of ChAT activity compared to the controls, they showed a decrease in the affinity and maximum number of post-synaptic muscarinic receptors. Scrapie virus thus alters the cholinergic system at the post-synaptic rather than at the pre-synaptic level.
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D006224:Cricetinae; D005260:Female; D008647:Mesocricetus; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D011812:Quinuclidines / Q000378:metabolism*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism*; D012608:Scrapie / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D012756:Sheep; D009435:Synaptic Transmission; D014018:Tissue Distribution; D014316:Tritium
D011812:Quinuclidines; D014316:Tritium; D011813:Quinuclidinyl Benzilate; D002795:Choline O-Acetyltransferase