Human retrovirus-induced IL-2 receptors and their possible role in transduction of continuous cell growth signal.
The first half of this report describes direct evidence for the interleukin 2 receptor (IL-2R)-inducing ability of human T-cell leukemia/lymphoma virus (HTLV). When an Epstein-Barr virus (EBV)-transformed human B-cell line, LCL-Kan was infected with HTLV or transfected with plasmid DNA containing defective HTLV genome (long terminal repeat (LTR)-gag-pX-LTR), LCL-Kan cells were altered to express IL-2R which was indistinguishable from that of normal activated T cells. The second half of this paper reports that IL-2 could inhibit proliferation of HTLV-carrying T-cell lines which were spontaneously immortalized from IL-2-dependent cells or peripheral blood cells containing ATL leukemia cells. These results suggest that expression of IL-2R may be induced by HTLV in HTLV-transformed cells, where the IL-2R plays an important role in transduction of continuous cell growth signal.
D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D017977:Deltaretrovirus / Q000235:genetics / Q000472:pathogenicity*; D066246:ErbB Receptors; D005814:Genes, Viral; D006801:Humans; D011956:Receptors, Cell Surface / Q000032:analysis; D011971:Receptors, Immunologic / Q000096:biosynthesis* / Q000502:physiology; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes
D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D066246:ErbB Receptors