A double blind cross-over comparison of bunitrolol and placebo in the treatment of angina pectoris.
In 20 patients with stable angina pectoris, o-[3-(tert.-butylamino)-2-hydroxypropoxy]-benzonitrile (bunitrolol) was compared with placebo in a double blind cross-over trial, with monthly treatment periods. There was no difference in the subjective condition of the patient. The bunitrolol treated patients showed a significantly better work capacity (P less than 0.05) and pressure-rate product (P less than 0.01) in the exercise tests. No significant difference could be found in the ST-segment changes. The bunitrolol patients showed a significant reduction in heart rate at rest (P less than 0.01); a significant difference in blood pressure was not found. Bunitrolol is an effective beta-adrenergic blocker, without side-effects in this trial.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D004341:Drug Evaluation; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010919:Placebos; D011412:Propanolamines / Q000627:therapeutic use*
D010919:Placebos; D011412:Propanolamines