Immunodeficiency-disease-associated atypical chronic hepatitis: a clinicopathologic study.
Chronic hepatitis occurring in patients with primary immunodeficiency disease is an uncommonly reported phenomenon. This study describes our experience with 3 patients with various immunologic abnormalities who developed chronic atypical lymphocytic infiltrates in the liver. There was a temporal relationship to Epstein-Barr virus infection in 2 cases and hepatitis A in 1. In view of the increased incidence of malignant lymphoma in several of the primary immunodeficiency states, these cases present a difficult diagnostic challenge. The recognition of the association of infiltration of the liver with small cleaved lymphocytes and a viral infection in an immunodeficient patient should alert the pathologist to the possibility that the infiltrate does not represent malignant lymphoma. These cases may be analogous to similar virus-associated lymphoproliferative disorders described in the acquired immunodeficiency of renal transplantation.
D000293:Adolescent; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006518:Hepatitis Viruses / Q000276:immunology; D006521:Hepatitis, Chronic / Q000209:etiology / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000276:immunology; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D008223:Lymphoma / Q000473:pathology