Demonstration of SV40-related tumour antigen in human meningiomas by different hamster SV40-T-antisera.
Three of 5 human meningiomas tested in cell culture expressed SV40-related tumour (T) antigen as measured by indirect immunofluorescence with four different hamster anti-SV40 tumour sera. The per cent of T-antigen-positive nuclei varied depending on the antisera used. In one case (meningioma G. S.), only 25% of the T-antigen-positive nuclei detected with one antiserum could be demonstrated with another serum. The possible explanations are discussed. None of the meningioma cell cultures tested expressed SV40-related viral capsid (V) antigen.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D000957:Antigens, Viral, Tumor; D002467:Cell Nucleus / Q000276:immunology; D002478:Cells, Cultured; D006224:Cricetinae; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera; D008579:Meningioma / Q000276:immunology*; D013539:Simian virus 40 / Q000276:immunology*
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor; D007106:Immune Sera