title: Mast cell histamine, a local mitogen acting via H2-receptors in nearby tissue cells.
abstract: The tissue mast cell is the major storage site of histamine in the body. The present study is concerned with the effect of one histamine H1- and one histamine H2-receptor antagonist on proliferation in the rat mesentery following drug-induced mast-cell secretion. The H2-receptor antagonist, but not the H1-receptor antagonist, significantly suppressed mast-cell-mediated proliferation in vivo and in organ-cultured mesentery. This finding indicates that mast-cell-histamine is a mitogen acting directly on histamine H2-receptors in surrounding tissue cells.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000032:analysis*; D008643:Mesentery; D008934:Mitogens / Q000494:pharmacology*; D051381:Rats; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2
chemical_list: D008934:Mitogens; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D006632:Histamine