title: Chemotherapeutic inhibitors of the enzymes of the de novo pyrimidine pathway.
mesh_terms: D000818:Animals; D001221:Aspartate Carbamoyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000037:antagonists & inhibitors / Q000378:metabolism; D004080:Dihydroorotase / Q000037:antagonists & inhibitors / Q000378:metabolism; D004081:Dihydroorotate Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D009962:Orotate Phosphoribosyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011743:Pyrimidines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D004791:Enzyme Inhibitors; D011743:Pyrimidines; D004081:Dihydroorotate Oxidase; D001221:Aspartate Carbamoyltransferase; D009962:Orotate Phosphoribosyltransferase; D004080:Dihydroorotase; D009964:Orotidine-5'-Phosphate Decarboxylase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)