Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor.
Purified growth inhibitor from BSC-1 cells and type beta transforming growth factor from human platelets are shown to have nearly identical biological activity and to compete for binding to the same cell membrane receptor. These findings suggest that the growth inhibitor and the type beta transforming growth factor are similar molecules. The data also show that the same purified polypeptide can either stimulate or inhibit cell proliferation depending on the experimental conditions.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002522:Chlorocebus aethiops; D004247:DNA / Q000096:biosynthesis; D006131:Growth Inhibitors / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism* / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism; D015291:Transforming Growth Factors
D006131:Growth Inhibitors; D010455:Peptides; D011956:Receptors, Cell Surface; D015291:Transforming Growth Factors; D004247:DNA