Human T-cell leukemia virus: transformation in vitro of nonhuman primate T-lymphocytes and experimental inoculation of nonhuman primates.
T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. This finding may provide a potential model for investigating the possible interaction between a herpesvirus and T-lymphotropic retroviruses in the clinical condition AIDS.
D000818:Animals; D000956:Antigens, Viral; D002144:Callithrix; D002478:Cells, Cultured; D017977:Deltaretrovirus / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D012452:Saguinus; D012453:Saimiri; D013601:T-Lymphocytes / Q000276:immunology*
D000956:Antigens, Viral