title: Biotransformation and excretion of methylcyclopentadienyl manganese tricarbonyl in the rat.
abstract: The biotransformation and excretion of methylcyclopentadienyl manganese tricarbonyl (MMT) has been studied in vivo in the rat, and in vitro by using rat liver and lung microsomes. Orally administered 3H-MMT is efficiently absorbed, metabolized, and excreted in the urine as two major metabolites, (CO)3MnC5H4CO2H and (CO)3MnC5H4CH2OH, which account for 67% and 14% of the urinary tritium, respectively. There metabolites are also excreted in significant quantities in bile, but undergo reabsorption and excretion by the kidney since only a small fraction of the administered tritium appears in the feces. In vitro MMT was rapidly metabolized by a cytochrome P-450-dependent process inducible in liver but not in lung microsomes. In vivo induction by phenobarbital doubles the rate of biliary excretion of MMT metabolites and confers a remarkable protection against the toxic effect of MMT.
mesh_terms: D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005243:Feces / Q000032:analysis; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008345:Manganese / Q000378:metabolism* / Q000652:urine; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009942:Organometallic Compounds / Q000378:metabolism* / Q000652:urine; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
chemical_list: D009942:Organometallic Compounds; D000632:Aminopyrine; C009907:2-methylcyclopentadienyl manganese tricarbonyl; D008345:Manganese; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital