title: [Vascular functional disorders in insulin-dependent diabetes].
abstract: In 60 patients with manifest diabetes mellitus of juvenile onset type in whom no peripheral macroangiopathy was present for objectifying disturbances of the vascular function angiological measurements in rest and after pedal-ergometric load were performed in the region of the lower extremity. In comparison to test persons with healthy metabolism diabetes showed significantly shorter pulse were times due to decreased elasticity of arteries. The behaviour of the rheographic and doppler-sonographic parameters corresponded to a larger and longer lasting dilatation of the muscular arterioles after load. Correlations between these functional changes and the severity of a microangiopathy (retinopathy) or their ascertained influence factors could not be proved in the examined number of patients. Disturbances of the haemodynamic vasomotor function are in diabetes above all to be evaluated as signs of the autonomous neuropathy. Moreover, the regulation of the blood supply changed under muscle work is connected with an increased catecholamine-conditioned stimulation of adrenergic beta 2-receptors of the vascular wall and further local metabolic as well as haemorheologic deviations.
mesh_terms: D000318:Adrenergic beta-Agonists; D002395:Catecholamines / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000150:complications*; D006439:Hemodynamics; D006801:Humans; D005082:Physical Exertion; D014463:Ultrasonography
chemical_list: D000318:Adrenergic beta-Agonists; D002395:Catecholamines
vernacular_title: Vaskuläre Funktionsstörungen beim insulinabhängigen Diabetes.