title: Hypothalamic substances in the control of body temperature: general characteristics.
abstract: Although it has been demonstrated that their central, exogenous application induces thermal responses, it is not yet established whether various substances found in the hypothalami of many species function as neurotransmitters in central thermoregulatory pathways. Available data concerning their presence, synthesis, release, possible binding sites, and inactivation are reviewed in the light established criteria for determining a neurotransmitter role for such substances.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000596:Amino Acids / Q000502:physiology; D000818:Animals; D001833:Body Temperature Regulation; D004723:Endorphins / Q000502:physiology; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000502:physiology; D005971:Glutamates / Q000502:physiology; D018698:Glutamic Acid; D006632:Histamine / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D009074:Melanocyte-Stimulating Hormones / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D010455:Peptides / Q000502:physiology; D011957:Receptors, Opioid / Q000502:physiology; D013654:Taurine / Q000502:physiology; D001615:beta-Endorphin; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D000596:Amino Acids; D004723:Endorphins; D004745:Enkephalins; D005971:Glutamates; D018377:Neurotransmitter Agents; D010455:Peptides; D011957:Receptors, Opioid; D013654:Taurine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D004744:Enkephalin, Methionine; D001615:beta-Endorphin; D006632:Histamine; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones