[Role of bradykinin in hypotension induced by the active factor derived from factor XII].
The active fragment derived from factor XII (factor XIIf) was purified from human plasma and administered intravenously to normotensive conscious rats. Factor XIIf-mediated hypotension was dose-dependent and augmented by pretreatment with captopril, an inhibitor of the angiotensin I- and bradykinin-processing enzyme. In contrast, factor XIIf-induced hypotension was not enhanced by blockade of the renin-angiotensin system by saralasin, a competitive antagonist of angiotensin II at the vascular receptor level. These results suggest that factor XIIf-mediated hypotension is due to the formation of bradykinin.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001920:Bradykinin / Q000096:biosynthesis / Q000502:physiology*; D002216:Captopril / Q000494:pharmacology; D005174:Factor XII / Q000494:pharmacology*; D015956:Factor XIIa; D007022:Hypotension / Q000209:etiology*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D010446:Peptide Fragments; D005174:Factor XII; D002216:Captopril; D015956:Factor XIIa; D012504:Saralasin; D001920:Bradykinin
Rôle de la bradykinine dans l'hypotension induite par le fragment actif dérivé du facteur XII.