[Effect of the antihistamine preparation, fencarol, and other quinuclidyldiarylcarbinols on tissue aminoxidase activity].
In experiments in vivo, the derivatives of quinuclidylarylcarbinol, possessing an antihistaminic activity, fencarol, its di(o-tolyl)- and di(o-methoxyphenyl)-derivatives activate histamine oxidative deamination by diaminoxidase of the rat lungs and increase the histamine tissue level. Quinuclidyl-3-dithienyl carbinol inhibits the activity of diaminoxidase, but decreases the histamine tissue level. On the contrary, dimedrol (diphenhydramine), pipolfen (promethazin), pyrilamine and cyproheptadin exerted no effect on the activity of diaminoxidase or the histamine tissue level. All the compounds studied did not alter oxidative deamination of the rat brain serotonin by monoamine oxidase or the serotonin content in brain tissues.
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D003641:Deamination; D004789:Enzyme Activation / Q000187:drug effects; D006632:Histamine / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects; D008297:Male; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D010880:Piperidines; D011619:Psychotropic Drugs; D011812:Quinuclidines; D012701:Serotonin; D006632:Histamine; D000587:Oxidoreductases Acting on CH-NH Group Donors; C014742:quifenadine
Vliianie protivogistaminnogo preparata fenkarola i drugikh khinuklidildiarilkarbinoov ba aktivnost' tkanevykh aminoksidaz.