Ethionine and methionine distribution and toxicity in the rat kidney.
Autoradiographic studies demonstrated that in the rat kidney radioactivity was localized mainly in the medulla in animals injected with [14C]ethionine, whereas it was distributed homogeneously throughout the whole parenchyma in rats given [14C]methionine. This difference of distribution was consistent with a difference in renal toxicity: a single i.p. dose (1 g/kg) of ethionine induced a slight but persistent (6 days) damage to kidney tubule cells evidenced by an increase of urinary GGT and slight disturbance of renal function, such damage was not observed with methionine.
D000818:Animals; D005001:Ethionine / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008715:Methionine / Q000633:toxicity*; D051381:Rats; D014018:Tissue Distribution; D014556:Urine / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000652:urine
D008715:Methionine; D005723:gamma-Glutamyltransferase; D005001:Ethionine