title: ACTH-producing hypophyseal carcinoma monitored by computed tomography.
abstract: A case of malignant ACTH-producing hypophyseal tumor with serial CT scan and histological investigation is discussed. The neoplasm became evident with a Cushing's syndrome and was treated with adrenalectomy and radiotherapy. Nelson's syndrome subsequently developed due to histologically atypical adenoma. Subarachnoid metastases occurred after 4 years, finally causing a fatal intracranial hemorrhage.
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary*; D001933:Brain Stem / Q000473:pathology*; D003388:Cranial Fossa, Posterior / Q000473:pathology; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D000324:Adrenocorticotropic Hormone