title: [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them].
abstract: Some activities of seven vegetable extracts and an association of them given by oral route were tested on the C.N.S. of the mouse. Among these, Crataegus oxyacantha and, less clearly, Valeriana officinalis show some sedative activity, whereas the extract from Passiflora incarnata gives some anxiolytic effect. Matricaria chamomilla and Piscidia erythrina stand in an intermediate position between the previous ones. Hyoscyamus niger proved to be active in only one of the tests performed, whereas Atropa belladonna did not show any activity on the C.N.S. The association of the seven extracts seemed to act in a synergetic way, the resulting activity being sedative at high dosage and anxiolytic at low dosage.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D047310:Apigenin; D001463:Barbiturates / Q000494:pharmacology; D001533:Belladonna Alkaloids / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D039823:Iridoids; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011714:Pyrans / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D014632:Valerian
chemical_list: D014151:Anti-Anxiety Agents; D001463:Barbiturates; D001533:Belladonna Alkaloids; D005419:Flavonoids; D006993:Hypnotics and Sedatives; D039823:Iridoids; D010936:Plant Extracts; D011714:Pyrans; C009643:valtrates (combination); C021329:vitexin rhamnoside; D047310:Apigenin
vernacular_title: Valutazione dell'attività sul S.N.C. del topo di alcuni estratti vegetali e di una loro associazione.