Effects of prosomatostatin on growth hormone and prolactin response to arginine in man. Comparison with somatostatin.
The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS). In comparison with SS, Pro-SS caused greater and more prolonged inhibition of GH release, a more marked reduction of the PRL response to arginine, and greater enhancement of the hyperglycaemic action of arginine. The greater potency and prolonged action of Pro-SS make it an interesting tool to study hormonal control mechanisms in a variety of physiological and pathological conditions.
D000328:Adult; D001120:Arginine / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007004:Hypoglycemic Agents; D007328:Insulin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D011498:Protein Precursors / Q000494:pharmacology*; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D011498:Protein Precursors; D013004:Somatostatin; C028456:prosomatostatin; D011388:Prolactin; D013006:Growth Hormone; D005934:Glucagon; D001120:Arginine