Studies on the kinetic properties of tryptophan hydroxylase of rabbit mesencephalon and pons medulla. Effect of long-term treatment with neuroleptics and antidepressants.
Tryptophan hydroxylase activity was measured in mesencephalon and pons medulla of rabbits receiving reserpine or other neuroleptics which are chemically related to phenothiazines (chlorpromazine), dibenzothiazepine (imipramine), dibenzobicyclooctadiene (maprotiline), dibenzothiepines (methiothepin), butyrophenones (haloperidol) and tetrahydro-isoquinolines (nomifensine). Chronic i.m. administration of imipramine and nomifensine increased the affinity of mesencephalic tryptophan hydroxylase for tryptophan. The injection of chlorpromazone increased the enzyme activity significantly in comparison to control values.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000201:enzymology*; D011149:Pons / Q000187:drug effects / Q000201:enzymology*; D011817:Rabbits; D014365:Tryptophan Hydroxylase / Q000378:metabolism*
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D014365:Tryptophan Hydroxylase