title: Double-blind controlled trial of three dosage regimens in treatment of haemarthroses in haemophilia A.
abstract: A double-blind controlled trial comparing doses of 7, 14, and 28 units/kg of factor VIII for knee, ankle, and elbow haemarthroses was carried out on a group of severe haemophiliacs. Mild-to-moderate ankle bleeds responded as well to 7 units/kg as to higher doses. All grades of knee bleeds fared worse when subjected to the lowest dose. Mild elbow bleeds responded to the lowest dose, but moderate elbow bleeds required higher doses.
mesh_terms: D000293:Adolescent; D000843:Ankle Joint; D001803:Blood Transfusion; D002648:Child; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004551:Elbow Joint; D005169:Factor VIII / Q000008:administration & dosage*; D005260:Female; D006395:Hemarthrosis / Q000628:therapy*; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D007719:Knee Joint; D008297:Male
chemical_list: D005169:Factor VIII