The development of cholangiocarcinoma from multiple bile-duct adenomas. Report of a case and review of the literature.
A patient was found to have multiple bile-duct adenomas at cholecystectomy. Autopsy 10 years later revealed an asymptomatic cholangiocarcinoma of the left hepatic bile-duct, in which a gradual dedifferentiation could be seen from a central adenoma-like structure to an infiltrating adenocarcinoma peripherally. Similar cases from the literature are reviewed and possible etiologic relationships are discussed.
D002759:Adenoma, Bile Duct / Q000473:pathology*; D000368:Aged; D001344:Autopsy; D001650:Bile Duct Neoplasms / Q000473:pathology*; D005705:Gallbladder Diseases / Q000601:surgery; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male