title: In vitro and in vivo activities of ketoconazole and itraconazole against Pityrosporum orbiculare.
abstract: The MICs of ketoconazole and itraconazole against Pityrosporum orbiculare were 0.02 to 0.05 and 0.1 to 0.2 micrograms ml-1, respectively. In a rabbit model, orally administered ketoconazole (1 mg kg-1) afforded protection against experimental pityriasis (tinea) versicolor in all animals. Itraconazole (5 mg kg-1) was effective in four of five rabbits.
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D008290:Malassezia / Q000187:drug effects*; D008297:Male; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D014010:Tinea Versicolor / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole