Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
Phosphonate analogues of carboxylic acids have been tested as antagonists of excitatory aminoacids in rat cerebral cortex. (+/-)--2-Amino-7-phosphono-heptanoic acid and the (-)-D-isomer of the pentanoate derivative were more potent and selective antagonists of N-methyl-D-aspartate (NMDA) than compounds tested previously. The results support the view that a distinct population of receptors exists which are preferentially activated by NMDA.
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004336:Drug Antagonism; D004553:Electric Conductivity; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007536:Isomerism; D007608:Kainic Acid / Q000494:pharmacology; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D014633:Valine / Q000031:analogs & derivatives* / Q000494:pharmacology
D005971:Glutamates; D009943:Organophosphorus Compounds; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; C031231:2-amino-7-phosphonoheptanoic acid; D007608:Kainic Acid