Effects of 5-hydroxytryptamine, fluoxetine and chlorimipramine on reflex bradycardia in rats.
In the urethane-anaesthetized rat, increasing 5-hydroxytryptaminergic receptor activity or functional 5-HT in brain with either the specific inhibitors of 5-HT reuptake (e.g. fluoxetine and chlorimipramine) or the 5-HT itself greatly reduced the reflex bradycardia induced by the systemically administered adrenaline. The data indicate that activation of central 5-HT-ergic receptors tends to inhibit reflex bradycardia.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000188:drug therapy; D001921:Brain / Q000187:drug effects; D002997:Clomipramine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology; D014520:Urethane / Q000494:pharmacology
D011437:Propylamines; D011985:Receptors, Serotonin; D005473:Fluoxetine; D012701:Serotonin; D014520:Urethane; D002997:Clomipramine; D004837:Epinephrine