The influence of fazadinium on the potassium efflux produced by succinylcholine.
Succinylcholine-induced potassium efflux was studied in two groups of healthy adult patients presenting for elective surgery. One group (Group 1) of 12 patients received alfathesin induction followed by succinylcholine. The other group (Group 2) of 12 patients were pre-treated with fazadinium 0.075 mg . kg-1 about three minutes before administration of alfathesin and succinylcholine. Serial blood samples were taken pre-induction, post-induction and after succinylcholine for estimation of plasma potassium. The results show that pre-treatment with fazadinium 0.075 mg . kg-1 was effective in preventing succinylcholine-induced potassium efflux.
D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000139:chemically induced / Q000517:prevention & control; D011188:Potassium / Q000097:blood*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013390:Succinylcholine / Q000494:pharmacology*
D011726:Pyridinium Compounds; D013390:Succinylcholine; D011188:Potassium