Use of the human "isolated arm" preparation to indicate qualitative aspects of a new neuromuscular blocking agent, ORG NC 45.
In the human isolated arm preparation Org NC 45 had a significantly faster rate of recovery and a shorter duration of action (end of injection to 90% recovery of control twitch height) than pancuronium. The isolated arm preparation is suitable for the qualitative comparison of the neuromuscular blocking activities of new and established drugs.
D001132:Arm; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium