Methoxyethylmercury nephrotoxicity: effects on enzymuria and kidney function.
The fungicide, methoxyethylmercury chloride, was given in a saline solution to four groups of Sprague-Dawley C D rats (5 male, 5 female) as a single injection (IP) of 0, 0.5, 1.0, and 2.0 mg Hg/kg. In a three-day period, no changes were observed in urine collected every 24 h from rats given 0 or 0.5 mg Hg/kg; 1 mg Hg/kg induced only a transient increase of urine gamma glutamyl transferase (x 4) and alkaline phsophatase (x 2.5) on the day 2; 2.0 mg Hg/kg caused an early increase of enzymuria (day 1 and day 2) and a decrease of Na+, Cl-, K+, urea, and creatinin excretion. Urine enzymes and total mercury excretion were higher in males. These time-related variations of enzymuria, compared to previous results with Hg Cl2, could reflect the existence of metabolites more toxic than the native compound.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004798:Enzymes / Q000652:urine*; D005034:Ethylmercuric Chloride / Q000031:analogs & derivatives* / Q000633:toxicity; D005035:Ethylmercury Compounds / Q000031:analogs & derivatives*; D005260:Female; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000201:enzymology; D008297:Male; D008628:Mercury / Q000652:urine; D051381:Rats; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D004798:Enzymes; D005035:Ethylmercury Compounds; C008397:neanthine; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D008628:Mercury; D005034:Ethylmercuric Chloride