[Physicochemical heterogeneity of the GABA receptors and the detection of the differences in their structural relation with benzodiazepine receptors].
The existence of two subpopulations of GABA-receptors was shown by cation-exchange chromatography and isoelectrofocusing methods. One of these populations was purified together with the benzodiazepine receptors. Isoelectric points determined for the two GABA-receptor subpopulations were 4.6 - 5.3 and 5.6 - 5.9. Isoelectric points for the benzodiazepine receptor were 5.6 - 6.1.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001569:Benzodiazepines; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002852:Chromatography, Ion Exchange; D007525:Isoelectric Focusing; D051381:Rats; D011955:Receptors, Drug / Q000032:analysis*; D011984:Sensory Receptor Cells / Q000032:analysis*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D014151:Anti-Anxiety Agents; D011955:Receptors, Drug; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid
Fiziko-khimicheskaia geterogennost' GAMK-retseptorov i vyiavlenie razlichiĭ v strukturnoĭ sviazi s benzodiazepinovymi retseptorami.