[Current theories of phagocytosis and methodological problems in the study of phagocytosis defects in diabetics].
The process of phagocytosis on bacteria is described: recognition of the bacterium by C3b- and Fc-receptors and possibly lektin-like substances on PMN surfaces; ingestion by an actin-myosin interaction in a local Ca++ gradient; simultaneous activation of a NADPH-oxidase and oxidative attack of the bacterial membrane. Special aspects: opsonization, dependence of the rate of phagocytosis on day-time, conditions of diabetics.
D000199:Actins / Q000378:metabolism; D000907:Antibodies, Bacterial / Q000276:immunology; D001419:Bacteria / Q000276:immunology*; D002147:Calmodulin / Q000502:physiology; D003167:Complement Activation; D003920:Diabetes Mellitus / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D007473:Ion Channels / Q000378:metabolism; D008163:Luminescent Measurements; D008858:Microscopy, Phase-Contrast; D009218:Myosins / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D019255:NADPH Oxidases; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D010587:Phagocytosis; D011951:Receptors, Complement / Q000276:immunology; D017463:Receptors, Complement 3b; D011961:Receptors, Fc / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D000199:Actins; D000907:Antibodies, Bacterial; D002147:Calmodulin; D007075:Immunoglobulin M; D007473:Ion Channels; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D011961:Receptors, Fc; D014316:Tritium; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; D009218:Myosins; D013936:Thymidine
Neuere Theorien der Phagozytose und methodische Probleme bei der Untersuchung von Phagozytosedefekten bei Diabetikern.