Somatostatin and cimetidine in peptic-ulcer haemorrhage. A randomised controlled trial.
In a randomised controlled trial somatostatin was compared with cimetidine in the treatment of severe and persistent gastrointestinal bleeding due to peptic ulcer. The study was of a sequential design and lasted 2.5 years, when the designated level of significance had been reached. Of the 20 patients studied, 10 received somotostatin and 10 received cimetidine. In 7 of the 10 pairs of patients somatostatin was more effective than cimetidine; in 2 pairs somatostatin and cimetidine were both ineffective; and in 1 pair they were equally effective. Somatostatin may therefore be suitable for controlling peptic-ulcer bleeding in many patients who are unsuitable for surgery.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000150:complications*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006728:Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*; D011897:Random Allocation; D013004:Somatostatin / Q000008:administration & dosage / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000150:complications*
D006146:Guanidines; D006728:Hormones; D013004:Somatostatin; D002927:Cimetidine