Live attenuated varicella vaccine in children with leukemia in remission.
One-hundred-ninety-one children with acute leukemia in remission for at least one year were immunized with 1 or more doses of live attenuated varicella vaccine. All were susceptible to varicella prior to vaccination. The only significant side effect was mild to moderate rash, seen especially in children with maintenance chemotherapy temporarily suspended for one week before and one week after vaccination. Children with rash were at some risk (10%) to transmit vaccine virus to varicella susceptibles with whom they had close contact.
D000914:Antibodies, Viral / Q000096:biosynthesis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002644:Chickenpox / Q000517:prevention & control; D002648:Child; D005455:Fluorescent Antibody Technique; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
D000914:Antibodies, Viral; D000970:Antineoplastic Agents; D014613:Vaccines, Attenuated; D014765:Viral Vaccines