Localization of neurons containing pro-opiomelanocortin-related peptides in the hypothalamus and midbrain of the lizard, Anolis carolinensis: evidence for region-specific processing of beta-endorphin.
Immunohistochemical analyses of the lizard-brain, following colchicine pretreatment, revealed two populations of POMC-producing cell bodies located in medial-basal hypothalamus and the mesencephalic tegmentum. Analyses of extracts of lizard brain regions by radioimmunoassay and gel filtration chromatography indicate that beta-endorphin-sized and alpha-MSH-sized peptides are the major POMC-related end products. Evidence is presented for region-specific processing of beta-endorphin in the lizard brain.
D000818:Animals; D002850:Chromatography, Gel; D004723:Endorphins / Q000378:metabolism*; D007031:Hypothalamus / Q000032:analysis* / Q000378:metabolism; D008116:Lizards / Q000378:metabolism*; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D011333:Pro-Opiomelanocortin / Q000032:analysis*; D011863:Radioimmunoassay; D013681:Tegmentum Mesencephali / Q000032:analysis* / Q000378:metabolism; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D009074:Melanocyte-Stimulating Hormones