Biodisposition of theophylline. II. Effect of aromatic hydrocarbon treatment in mice.
The effect of polycyclic aromatic hydrocarbons on theophylline clearance was examined in six inbred mice strains. The DBA/2 and SJL strains were nonresponsive to this treatment, whereas C3H/HeJ, C57BL/6, BALB/c, and A/J strains were responsive. In the responsive strains, the total body clearance increased by a factor of 2.3 to 3.4, apparently due to a general induction of all metabolic pathways. The production of 1,3-dimethyluric acid was not increased in the C57BL/6 strain. The variation in induction among responsive strains appeared to be primarily associated with the increase in the oxidation to 1,3-dimethyluric acid.
D000818:Animals; D001571:Benzoflavones / Q000378:metabolism*; D001711:Biotransformation; D005419:Flavonoids / Q000378:metabolism*; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D011083:Polycyclic Compounds / Q000494:pharmacology*; D013045:Species Specificity; D013806:Theophylline / Q000378:metabolism* / Q000652:urine; D014970:Xanthines / Q000494:pharmacology; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D005419:Flavonoids; D011083:Polycyclic Compounds; D014970:Xanthines; D008748:Methylcholanthrene; D019324:beta-Naphthoflavone; D013806:Theophylline