Cumulative effect of X-ray radiation and inflammatory reaction on the circadian rhythm of tyrosine aminotransferase in the liver of mice.
The activity of tyrosine aminotransferase (TAT) in the liver of mice subjected simultaneously to ionizing radiation and to local inflammatory process showed in the first 24 hours of the experiment statistically significant changes resulting from summation of the harmful effects of both factors. In the second 24-hour period an evident tendency was observed for return of a normal circadian rhythm of the enzyme. This points to presence of an endogenous mechanism of suppression of the manifestations of significant desynchronization of the circadian rhythm. The paper contains also a trial of mathematical analysis of changes in TAT activity in the circadian rhythm, a description and analysis of the suppression process, qualitative and quantitative determination of the phenomenon of cumulation of the effects of powerful stress factors acting on the animal organism. The obtained results were compared with the results of investigations of TAT activity changes obtained in the case of separate application of the stress factors selected for this experiment.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects / Q000528:radiation effects; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008954:Models, Biological; D011833:Radiation Injuries, Experimental / Q000201:enzymology*; D014425:Turpentine / Q000009:adverse effects; D014444:Tyrosine Transaminase / Q000378:metabolism* / Q000528:radiation effects
D014444:Tyrosine Transaminase; D014425:Turpentine