Effects of structural variations of non-ionic surfactants on micellar properties and solubilization: surfactants based on erucyl and behenyl (C22) alcohols.
Studies on erucyl alcohol ethoxylated with 24 units and on behenyl alcohol ethoxylated with 21 ethylene oxide units gave values of 10.2 x 10(3) and 25.4 x 10(3) for the micellar weights, 74 and 203 for the aggregation number, and 134 and 106 moles water mole-1 surfactant for the micellar hydration, respectively. The solubilization of azobenzene, cortisone acetate, griseofulvin, sulphadiazine, phenylbutazone, betamethasone, tolbutamide, and menaphthone was studied in 2% solutions of the above surfactants, and in cetomacrogol. Excluding sulphadiazine, a linear relationship was found between moles solubilized/mole surfactant, and (log P)/molar volume of solubilizate.
D003102:Colloids; D005233:Fatty Alcohols; D008823:Micelles; D012995:Solubility; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents
D003102:Colloids; D005233:Fatty Alcohols; D008823:Micelles; D013501:Surface-Active Agents; C027036:erucyl alcohol; C529236:docosanol