The pathophysiology of extrapyramidal side-effects of neuroleptic drugs.
The mechanisms responsible for the production of major extrapyramidal side-effects (parkinsonism, akathisia, acute dystonic reactions, chronic tardive dyskinesias) are reviewed in the light of the complex effects of these drugs on cerebral dopamine systems.
D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D004421:Dystonia / Q000139:chemically induced; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D013565:Sympatholytics / Q000494:pharmacology
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D013565:Sympatholytics; D004298:Dopamine