The effects of nefopam on blood acid-base status in the rabbit: interactions with morphine in the mouse and rabbit.
Nefopam, a non-narcotic analgesic, had only minor effects upon the blood pH, PCO2 and standard bicarbonate of the conscious rabbit. In contrast morphine caused a dose-dependent increase in PCO2 and standard bicarbonate. When nefopam was administered in conjunction with morphine (2.5 mg kg-1 and 1 mg kg-1 i.v. respectively) the increase in PCO2 was greater than with morphine alone. Nefopam also increased the antinociceptive and respiratory frequency depressant effects of morphine in the mouse.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000700:Analgesics; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004347:Drug Interactions; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009340:Nefopam / Q000494:pharmacology*; D010079:Oxazocines / Q000494:pharmacology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D013045:Species Specificity
D000700:Analgesics; D010079:Oxazocines; D002245:Carbon Dioxide; D009340:Nefopam; D009020:Morphine