Binding studies in the Lurcher mutant suggest an uneven distribution of putative benzodiazepine receptor subclasses in the mouse cerebellum.
Binding studies using [3H]flunitrazepam in the cerebellum of normal and Lurcher mutant mice indicate that about 90% of the total benzodiazepine receptor population reside on the Purkinje and granule cells. Moreover, the specific binding of the BZ1 receptor subclass specific ligand [3H]propyl-beta-carboline-3-carboxylate suggests that neuronal elements of the mouse cerebellum other than the Purkinje and granule cells contain about 18% of the BZ1 receptors but only about 7% of the BZ2 receptors of the mouse cerebellum.
D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D008818:Mice, Neurologic Mutants; D011963:Receptors, GABA-A / Q000378:metabolism*; D013045:Species Specificity
D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005445:Flunitrazepam