The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures.
The autoradiographic identification of chemically-induced, unscheduled DNA synthesis in primary cultures of adult rat hepatocytes is currently being validated as a predictive test for mutagens/carcinogens. Of 8 antihistaminic drugs tested, 2, pyrilamine maleate and tripelennamine HCl, were positive for unscheduled DNA synthesis. Further investigation of the mutagenic/carcinogenic potential of these compounds in alternate test systems is suggested.
D000818:Animals; D001345:Autoradiography; D002273:Carcinogens / Q000633:toxicity; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D006634:Histamine H1 Antagonists / Q000633:toxicity*; D008099:Liver / Q000378:metabolism*; D051381:Rats
D002273:Carcinogens; D006634:Histamine H1 Antagonists; D004247:DNA