[Normalization of SH-group concentration in brain tissue during sleep disorders].
In albino rats, after cessation of the 24-hr REM sleep deprivation, the SH-group content usually increased by that moment in brain-stem homogenates, dropped to its wakefulness level within 36 hr. Intraperitoneal injection of Phenazepam immediately after cessation of the REM sleep deprivation accelerated normalization of the SH-group content reducing the period to 12 hr. Phenazepam injection (0.5 mg/kg) before and in 12 hr after the REM sleep deprivation completely prevented the increase in the brain-stem SH-group content. Lower doses or a single injection before the REM sleep deprivation only decreased somewhat the SH-group accumulation.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001138:Armin / Q000494:pharmacology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D001933:Brain Stem / Q000032:analysis* / Q000187:drug effects; D005260:Female; D008297:Male; D051381:Rats; D012892:Sleep Deprivation; D012895:Sleep, REM / Q000502:physiology*; D013438:Sulfhydryl Compounds / Q000032:analysis*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D013438:Sulfhydryl Compounds; D001569:Benzodiazepines; C017928:phenazepam; D001138:Armin
O normalizatsii soderzhaniia SH-grupp v tkani golovnogo mozga pri narushenii sna.