title: Genetic control of developmental patterns of cerebral enzyme activities: further differences between C3H and ICR strains of mice.
abstract: We have investigated developmental changes in activity for five enzymes associated with different cerebral metabolic systems in two separate strains of mice. The enzymes studied were acid beta-galactosidase, arylsulfatase A, cerebroside beta-galactosidase, cerebroside sulfotransferase, and glutamate decarboxylase. The two strains of mice were C3H/SWV and ICR/SWV. We confirm the experiments of Meisler, Paigen, and colleagues showing higher acid beta-galactosidase activity throughout development in C3H mice. In addition we have demonstrated higher arylsulfatase A activity throughout development in C3H mice. The shape of the developmental curve for arylsulfatase A activity in brain in the two strains was similar. There were no differences in developmental changes of activity between the two strains for the other three enzymes studied.
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000254:growth & development; D002553:Cerebroside-Sulfatase / Q000378:metabolism*; D002554:Cerebrosides / Q000378:metabolism; D005696:Galactosidases / Q000378:metabolism*; D005698:Galactosylceramidase / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000254:growth & development; D051379:Mice; D008809:Mice, Inbred C3H / Q000502:physiology*; D008813:Mice, Inbred ICR / Q000502:physiology*; D013429:Sulfatases / Q000378:metabolism*; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism*
chemical_list: D002554:Cerebrosides; D013466:Sulfurtransferases; D015238:Sulfotransferases; C020556:galactosylceramide sulfotransferase; D013429:Sulfatases; D002553:Cerebroside-Sulfatase; D005696:Galactosidases; D001616:beta-Galactosidase; D005698:Galactosylceramidase; D005968:Glutamate Decarboxylase