Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.
Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D015232:Dinoprostone; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007375:Interleukin-1 / Q000494:pharmacology*; D053583:Interleukin-1beta; D051379:Mice; D003012:Microbial Collagenase / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D013552:Swine; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D007375:Interleukin-1; D053583:Interleukin-1beta; D011458:Prostaglandins E; D003012:Microbial Collagenase; D015232:Dinoprostone; D013936:Thymidine