Xanthine oxidase induced depolymerization of hyaluronic acid in the presence of ferritin.
Oxygen free radicals generated by xanthine oxidase are able to depolymerize hyaluronic acid in the presence of ferritin-bound iron. This suggests that ferritin can catalyse the Haber-Weiss reaction, leading to the formation of highly damaging hydroxyl radicals.
D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003676:Deferoxamine / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005293:Ferritins / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000378:metabolism*; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D013481:Superoxides / Q000378:metabolism; D014783:Viscosity; D014969:Xanthine Oxidase / Q000378:metabolism*
D006878:Hydroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D006820:Hyaluronic Acid; D005293:Ferritins; D004492:Edetic Acid; D014969:Xanthine Oxidase; D003676:Deferoxamine