Effects of alfa-receptor and adrenergic neuron blockade on indomethacin-induced changes of renal haemodynamics.
The effect of prostaglandin synthesis inhibitor indomethacin was studied on renal haemodynamics by radioactive microspheres in untreated control dogs and in animals treated by the alfa-adrenergic receptor blocking agent phentolamine or by the adrenergic neuron blocking agent guanethidine. RBF was reduced by indomethacin. The reduction of blood flow was more pronounced in the inner cortical zones, which resulted in a blood flow redistribution towards the superficial cortical regions. Urine flow, osmotic concentration and electrolyte excretion did not change significantly. Pretreatment by phentolamine or by guanethidine did not influence the effect of indomethacin on renal haemodynamics or renal function. These data suggest that the sympathetic nervous system is not involved in the renal effects of indomethacin.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006145:Guanethidine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply*; D010646:Phentolamine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013565:Sympatholytics / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D013565:Sympatholytics; D007213:Indomethacin; D010646:Phentolamine; D006145:Guanethidine