Virus-induced blast transformation of lymphocytes and its inhibition by F(ab1)2 fragments of human IgG.
Blast transformation of lymphocytes from persons immunized by vaccines against tick-borne Japanese encephalitides, in response to stimulation by homologous viral antigens was studied. 3H-Thymidine incorporation into lymphocytes was completely inhibited by F(ab1)2 fragments of normal human IgG containing no antibody to the viruses examined. A correlation of the inhibitory action of F(ab1)2 fragments on lymphocyte transformation induced by viruses and phytohaemagglutinin was observed.
D000956:Antigens, Viral / Q000276:immunology*; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology
D000956:Antigens, Viral; D007140:Immunoglobulin Fab Fragments; D010835:Phytohemagglutinins