A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after alpha-noradrenergic receptor blockade.
Nine marmosets (Callithrix jacchus) were tested on a variety of visual discrimination learning tasks in a Wisconsin General Test Apparatus with or without alpha-noradrenergic receptor blockade achieved by the administration of aceperone. After aceperone, animals were found to be severely and consistently impaired at learning the first task of each test session and to be impaired on new and repeated reversal learning. They were, however, unimpaired on learning another similar task in each test session and on performance of a well-learnt task. Results were interpreted as evidence for defective association formation which can be compensated for by suitable priming or practice.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D002090:Butyrophenones / Q000494:pharmacology; D002143:Callitrichinae; D005260:Female; D007858:Learning / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D011340:Problem Solving / Q000187:drug effects*; D012193:Reversal Learning / Q000187:drug effects; D013997:Time Factors; D014163:Transfer, Psychology / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D002090:Butyrophenones; D009638:Norepinephrine