Induction of hyperphagia in rats by intracerebroventricular infusion of sodium pentobarbital. A method for testing anorexigenic compounds.
In rats hyperphagia could be reversibly induced by intracerebroventricular infusion of sodium pentobarbital. Hyperphagia was elicited in a dose dependent manner, the optimal infusion rate being 1000 micrograms/h sodium pentobarbital. At this rate, feeding behaviour was induced selectively, with only minor side effects being apparent. Systemic application of d-methamphetamine or propylhexedrine given prior to infusion resulted in a dose dependent reduction of hyperphagia. The method, therefore, could be useful for testing putative anorexigenic compounds in hyperphagic rats.
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005247:Feeding Behavior / Q000187:drug effects*; D007263:Infusions, Parenteral; D007276:Injections, Intraventricular; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D011437:Propylamines / Q000494:pharmacology; D051381:Rats
D001067:Appetite Depressants; D011437:Propylamines; D008694:Methamphetamine; D010424:Pentobarbital