The influence of foot-shock stress upon brain, pituitary and spinal cord pools of immunoreactive dynorphin in rats.
The distribution of immunoreactive-dynorphin (ir-dyn) in the pituitary, discrete regions of brain and the spinal cord, and the influence of 5 min foot-shock stress (FS) upon levels of ir-dyn in these structures, were examined in rats. FS produced a significant fall in the anterior pituitary lobe (AL) content of ir-dyn but no significant change in its neurointermediate (NIL) counterpart. In the hypothalamus, in contrast, a significant elevation in levels of ir-dyn was observed. With the exception of the frontal cortex, in which a decrease in levels of ir-dyn was found, in all other brain regions examined no significant changes emerged. A significant diminution in concentrations of ir-dyn in both the lumbosacral and thoracic sections of the spinal cord was, however, detected.
D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004399:Dynorphins; D004597:Electroshock; D004723:Endorphins / Q000032:analysis*; D006801:Humans; D007031:Hypothalamus / Q000503:physiopathology; D007118:Immunoassay; D008297:Male; D010902:Pituitary Gland / Q000503:physiopathology*; D051381:Rats; D013116:Spinal Cord / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology*; D014018:Tissue Distribution
D004723:Endorphins; D004399:Dynorphins