alpha 2-Adrenoceptor agonistic effect of B-HT 920 in isolated perfused hindquarters of rats.
In isolated perfused hindquarters of rats pretreated with reserpine the alpha 2-adrenoceptor selective agonist B-HT 920 decreased the flow dose-dependently. This effect was strongly antagonized by yohimbine and less by prazosin, and the reverse potency was demonstrated for methoxamine. With increasing concentrations of B-HT 920, a half maximal effect was achieved with 10(-6.64) M. This value is discussed wih respect to the antagonistic potency of B-HT 920 at alpha 1-adrenoceptors with a pA2 of 4.9.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D006614:Hindlimb / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D010477:Perfusion; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D015016:Yohimbine / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D001381:Azepines; D015016:Yohimbine; C024763:talipexole; D008729:Methoxamine; D011224:Prazosin