Inhibition by Cu2+ of amphotericin B induced lysis of erythrocytes.
Amphotericin B-induced lysis of erythrocytes is diminished in the presence of Cu2+, but the prelytic amphotericin B-induced K+ leakage is unaffected. These results and the weak binding of Cu2+ to amphotericin B, demonstrated by circular dichroism and EPR studies, are consistent with the view that Cu2+ protects erythrocytes by increasing their resistance to lysis.
D000666:Amphotericin B / Q000037:antagonists & inhibitors*; D002942:Circular Dichroism; D003300:Copper / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D010539:Permeability; D011188:Potassium / Q000097:blood
D003300:Copper; D000666:Amphotericin B; D011188:Potassium