[Cholinergic antagonism by beta-blockers. II. Sequence of interactions and final steady state effects].
On spontaneously beating guinea pig auricles, by assaying acetylcholine and beta-blockers alternate timing, opposite selective initial reactivity had been shown, partially independent of final steady state specific antagonism. Data related to cyclic receptor-sensitivity on acute versus subacute drug combination interaction had been presented.
D000109:Acetylcholine / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D007741:Labetalol / Q000494:pharmacology; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011950:Receptors, Cholinergic; D011433:Propranolol; D008790:Metoprolol; D007545:Isoproterenol; D000109:Acetylcholine; D007741:Labetalol; D011217:Practolol
Antagonismi colinergici di beta - bloccanti. II. Sequenza di interazione ed effetti finali stazionari.