[Presence of specific bradykinin receptors in arterial and venous smooth muscle].
The relationship between bradykinin action and its concentration was examined on isolated rings of the rabbit aorta, femoral artery, jugular vein and on isolated strips of the rat portal vein. The sensitivity of femoral artery and portal vein smooth muscles to bradykinin was disclosed. Venous smooth muscles were more sensitive to bradykinin as compared with arterial smooth muscles. Dissociation constants for the rabbit aorta, femoral artery, jugular vein and for the rat portal vein were 3.98 X 10(-6), 6.3 X 10(-6), 1.26 X 10(-7), and 7.6 X 10(-9)M, respectively. Effects of endogenous bradykinin in vivo might result from its primary action on the venous smooth muscle, action on the arterial smooth muscle and veno-arterial interactions.
D000818:Animals; D001011:Aorta / Q000032:analysis; D001920:Bradykinin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005263:Femoral Artery / Q000032:analysis; D066298:In Vitro Techniques; D007601:Jugular Veins / Q000032:analysis; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000032:analysis* / Q000187:drug effects; D009928:Organ Specificity; D011169:Portal Vein / Q000032:analysis; D011817:Rabbits; D051381:Rats; D018002:Receptors, Bradykinin; D011956:Receptors, Cell Surface / Q000032:analysis*
D018002:Receptors, Bradykinin; D011956:Receptors, Cell Surface; D001920:Bradykinin
O nalichii spetsificheskikh retseptorov k bradikininu v gladkoĭ myshtse arterii i ven.