[Effect of methylene diphosphonic acid on certain processes in animal tissues].
It was shown that methylene diphosphonic acid, a structural analogue of pyrophosphate, exhibiting immunodepressant properties, in a dose of 40 micrograms/g body weight inhibits by 20% the activity of inorganic pyrophosphatase in the spleen of BALB mice and does not affect this enzyme in the liver or thymus. In noninbred albino mice inhibition of the activity of the enzyme was recorded only as a result of administering the preparation in a dose of 80 micrograms/g. Histological data on the kidneys, liver, lungs, spleen, lymphatic nodes and thymus indicate that the preparation does not exert a significant toxic action on the body.
D000818:Animals; D004164:Diphosphonates / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D011755:Pyrophosphatases / Q000378:metabolism; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects; D013997:Time Factors
D004164:Diphosphonates; C027474:methylene diphosphonate; D011755:Pyrophosphatases
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