title: Neuronal protein phosphorylation: recent studies concerning protein I, a synapse-specific phosphoprotein.
abstract: Recent studies are described concerning the physiological role and tissue distribution of Protein I, a synapse-specific phosphoprotein. This protein is present in both the central and the peripheral nervous system and appears to be enriched in synaptic vesicles. It is a major substrate for both Ca2(-)- and cyclic AMP-dependent phosphorylation in the brain. In slices of the facial motor nucleus from rat brainstem, serotonin (5-HT) added to the incubation medium stimulates the phosphorylation of Protein I. This effect is potentiated by low concentrations of isobutylmethylxanthine and is prevented by the serotonin antagonist mianserin.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D008803:Mianserin / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010766:Phosphorylation; D012701:Serotonin / Q000502:physiology; D013569:Synapses / Q000502:physiology; D016704:Synapsins; D013570:Synaptic Membranes / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D016704:Synapsins; D008803:Mianserin; D012701:Serotonin; D000242:Cyclic AMP