A case of pseudohypoparathyroidism (PHP) associated with multiple hormonal abnormalities.
A case of pseudohypoparathyroidism (PHP) associated with several hormonal abnormalities in addition to parathyroid hormone (PTH) was reported. Several endocrinological examinations before and after treatment with 1 alpha-OH-D3 revealed abnormal thyroid stimulating hormone and prolactin responses to thyrotropin releasing hormone, abnormal plasma renin activity responses to renin stimulation test, and abnormal calcitonin responses to calcium infusion test. These abnormalities were not corrected when serum calcium levels returned to normal after therapy. From these results, it was suggested that in PHP resistance to multiple hormones that worked by stimulating adenylate cyclase might be the cause of these hormonal abnormalities, irrespective of serum calcium levels.
D000328:Adult; D002118:Calcium / Q000097:blood; D000242:Cyclic AMP / Q000096:biosynthesis; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D008297:Male; D011388:Prolactin / Q000378:metabolism; D011547:Pseudohypoparathyroidism / Q000188:drug therapy / Q000378:metabolism*; D012083:Renin / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D006728:Hormones; D006887:Hydroxycholecalciferols; D014667:Vasopressins; D011388:Prolactin; D013972:Thyrotropin; D000242:Cyclic AMP; D012083:Renin; D002118:Calcium; C008088:alfacalcidol