title: Effects of imide analogs on enzymes required for cholesterol and fatty acid synthesis.
abstract: Twelve imide analogs were examined for their ability to lower serum cholesterol and triglyceride levels in mice. Potent activity was observed for compounds containing a phthalimide or saccharin ring structure. The ability to lower serum cholesterol appears to be related to the ability to suppress acetyl-CoA synthetase activity. The availability of acetyl-CoA in the cytoplasm is a key regulatory component for cholesterol and fatty acid synthesis. The capacity to reduce serum triglycerides was related directly to the ability of the compound to inhibit acetyl-CoA carboxylase activity, the regulatory enzyme of fatty acid synthesis.
mesh_terms: D000106:Acetate-CoA Ligase / Q000037:antagonists & inhibitors; D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors; D005227:Fatty Acids / Q000096:biosynthesis*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007094:Imides / Q000494:pharmacology*; D051379:Mice
chemical_list: D005227:Fatty Acids; D000960:Hypolipidemic Agents; D007094:Imides; D002784:Cholesterol; D064429:Fatty Acid Synthases; D000106:Acetate-CoA Ligase; D000103:Acetyl-CoA Carboxylase