Peptides and thermoregulation.
Several peptides are now known to affect thermoregulation. These include beta-endorphin, bombesin, MIF-I, alpha-MSH, neurotensin, TRH, and DSIP. Some of these have been found to interact with the thermal effects of d-amphetamine, a drug with well established actions on thermoregulation. The effects of morphine on body temperature provide some notable comparisons with beta-endorphin, as do the similarities between the effects of naloxone and MIF-I. In general, it seems that two of the major variables which interact and modify the thermal effects of peptides are ambient temperature and route of administration.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009496:Neurotensin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D004723:Endorphins; D010455:Peptides; D009270:Naloxone; D009496:Neurotensin; D013973:Thyrotropin-Releasing Hormone; D009020:Morphine; D009074:Melanocyte-Stimulating Hormones; D009075:MSH Release-Inhibiting Hormone; D001839:Bombesin; D003913:Dextroamphetamine