title: Inhibitory effect of somatostatin on gastric acid secretion and serum gastrin in dogs with and without duodenogastric reflux.
abstract: The hypersecretion of gastric acid in response to pentagastrin, caused by duodenal reflux, was tested in dogs. An infusion of 0.25 micrograms/kg/h was found to restore the raised responses seen in the reflux dogs to control levels. Somatostatin was a strong inhibitor of pentagastrin-stimulated acid secretion and of gastrin release, but it was a weak inhibitor of histamine. These studies suggest that somatostatin may have played a part in acid homeostasis.
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000502:physiology*; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood* / Q000378:metabolism; D006633:Histamine Antagonists / Q000494:pharmacology; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D013004:Somatostatin / Q000494:pharmacology*; D013270:Stomach / Q000502:physiology
chemical_list: D005755:Gastrins; D006633:Histamine Antagonists; D013004:Somatostatin; D010418:Pentagastrin