[Platinum complexes as radiosensitizers in radiotherapy].
The authors study the radiosensitizing effect of cisplatinum, cis-dichloroethylenediamine platinum (II), and cis-dichlorobis-cyclohexylamine platinum (II) by the of TC-SV40 cells radiated under aerobic and hypoxic conditions. Cis-platinum shows the highest radiosensitizing activity but is very toxic. Perhaps cis-dischloro-bis-cyclohexylamine platinum (II) could be assayed as a less toxic radiosensitizing agent. On the other hand, DNA synthesis is studied in mouse spleen and TC-SV40 cells labeled with tritiated thymidine. Cis-platinum inhibitory activity is related to the preincubation time, cis-dichloroethylenediamine platinum(II) does not inhibit the semiconservative synthesis and stimulates the repair synthesis of DNA, and cis-dichloro-bis-cyclohexylamine platinum (II) produces a 60 per 100 inhibition of the semiconservative synthesis and a smaller inhibition of the repair synthesis.
D000693:Anaerobiosis; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002472:Cell Transformation, Viral; D002945:Cisplatin / Q000494:pharmacology* / Q000633:toxicity; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D006918:Hydroxyurea / Q000633:toxicity; D066298:In Vitro Techniques; D051379:Mice; D009944:Organoplatinum Compounds / Q000494:pharmacology* / Q000633:toxicity; D011829:Radiation Dosage; D011838:Radiation-Sensitizing Agents / Q000633:toxicity; D013539:Simian virus 40; D013154:Spleen / Q000166:cytology / Q000378:metabolism
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D011838:Radiation-Sensitizing Agents; C002892:platinum ethylenediamine dichloride; C022095:dichlorobis(cyclohexylamine)platinum; D004247:DNA; D002945:Cisplatin; D006918:Hydroxyurea
Complejos de platino como radiosensibilizadores en radioteriapia.