Activation of beta-adrenergic receptors stimulates taurine release from glial cells.
Activation of adrenergic receptors in primary cultures of astrocytes and LRM55 glial cells stimulates taurine release. Release is inhibited by the beta-adrenergic antagonists alprenolol and propanolol but not by the alpha-adrenergic antagonist phentolamine. Receptor-mediated taurine release occurs via a specific mechanism, since efflux of other amino acids and metabolites is not affected by the beta-adrenergic agonist isoproterenol.
D000526:Alprenolol / Q000494:pharmacology; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002395:Catecholamines / Q000494:pharmacology; D002478:Cells, Cultured; D002999:Clone Cells; D007545:Isoproterenol / Q000494:pharmacology; D009457:Neuroglia / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013654:Taurine / Q000378:metabolism*
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D013654:Taurine; D000526:Alprenolol; D011433:Propranolol; D007545:Isoproterenol