title: Disorders of neuromuscular transmission other than myasthenia gravis.
abstract: Disorders of neuromuscular transmission in humans are caused by a wide variety of agents including systemic diseases, drugs, environmental toxins, animal envenomation, cations, and hormones. Some are genetically determined. Many are of known etiology. All such disorders interfere with one or more events in the sequence whereby a nerve impulse excites a muscle action potential. In many disorders of neuromuscular transmission, abnormal fatigue occurs, and some cases respond dramatically to treatment. Investigation of the microphysiology, microanatomy, and pharmacology of both normal and diseased neuromuscular junctions has increased our knowledge of these disorders.
mesh_terms: D000200:Action Potentials; D001180:Arthropod Venoms / Q000506:poisoning; D001906:Botulism; D002800:Cholinesterase Inhibitors / Q000009:adverse effects; D006801:Humans; D008274:Magnesium / Q000506:poisoning; D009045:Motor Endplate / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000503:physiopathology; D009422:Nervous System Diseases / Q000503:physiopathology; D009468:Neuromuscular Diseases / Q000209:etiology*; D009469:Neuromuscular Junction / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D012910:Snake Venoms / Q000506:poisoning; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D001180:Arthropod Venoms; D002800:Cholinesterase Inhibitors; D018377:Neurotransmitter Agents; D012910:Snake Venoms; D008274:Magnesium