Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells.
We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2Lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24. This suggests that certain environmental substances, especially those known to be tumor promoters, may activate the HTLV-gene in ATL cells.
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002273:Carcinogens / Q000633:toxicity*; D002460:Cell Line; D017977:Deltaretrovirus / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D007938:Leukemia; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes; D014764:Viral Proteins / Q000096:biosynthesis*
D000954:Antigens, Surface; D000956:Antigens, Viral; D002273:Carcinogens; D014764:Viral Proteins