Monoclonal IgM with anti-muscle tissue activity in a patient with Waldenström's macroglobulinaemia: secretion of identical immunoglobulin by the established lymphoid cell line.
The monoclonal IgM kappa protein from a patient with Waldenström's macroglobulinaemia displayed antibody like activity against muscle and alpha-actinin. An Epstein-Barr virus associated lymphoid cell line, spontaneously established from blood lymphocytes, has been continuously secreting an immunoglobulin of the same isotype, isoelectric focusing spectrotype and reactivity; the cell line is probably leukaemic in origin since all cells display the translocation t (1; 19) and are aneuploid. We suggest these two monoclonal immunoglobulins have a common malignant origin.
D000368:Aged; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis / Q000276:immunology; D007621:Karyotyping; D008214:Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D009132:Muscles / Q000276:immunology*; D014178:Translocation, Genetic; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology*
D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains