title: [Somatostatin. I: Structure, biosynthesis and effect].
abstract: Somatostatin is synthetized and stored in the D-cells of pancreatic islets. It seems to inhibit immediately the secretion of insulin and glucagon which are synthesized in the B- and A-cells, respectively. For better understanding of these processes problems of cell differentiation of the pancreas as well as the mechanism of action of somatostatin are discussed. By means of analogues of somatostatin the half-life time and selectivity of the action can be increased obtaining a better possibility for clinical use.
mesh_terms: D002454:Cell Differentiation; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000166:cytology / Q000502:physiology; D013004:Somatostatin / Q000502:physiology*
chemical_list: D007328:Insulin; D013004:Somatostatin; D005934:Glucagon
vernacular_title: Somatostatin. Teil I: Struktur, Bildung, Wirkung.