Comparison of sodium and stannous fluoride nephrotoxicity.
Single i.p. injections of 0.5 mmol F-/kg and repeated i.p. injections of 0.25 mmol F-/kg as NaF or SnF2 to male rats showed that both compounds produced early lesions of kidney tubule demonstrated by an intense increase of urine gamma-glutamyl transferase (GGT). Disturbance of kidney function with an increase of diuresis and phosphaturia and a decrease of natriuria and kaliuria were more marked in SnF2-treated animals as was the decrease of urine GGT after a few days. These results indicate that tin nephrotoxicity adds to that of fluoride and antagonizes tubule regeneration.
D000818:Animals; D005459:Fluorides / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D051381:Rats; D012969:Sodium Fluoride / Q000633:toxicity*; D014002:Tin Fluorides / Q000633:toxicity*; D005723:gamma-Glutamyltransferase / Q000652:urine
D014002:Tin Fluorides; D012969:Sodium Fluoride; D005723:gamma-Glutamyltransferase; D005459:Fluorides