title: [Dynamics of beta-lipotropin and beta-endorphin levels in Itsenko-Cushing disease patients being treated with the antiserotonin preparation cyproheptadine (peritol) and chloditan].
abstract: The authors provide the data on the changes in the blood content of opioid neuropeptides in patients with Icenko-Cushing's disease treated with an antiserotonin drug peritol. The high content of beta-endorphine and beta-lipotropin in the patients' blood was one of the factors determining activation of the hypothalamus-pituitary-adrenal system. The treatment of patients with Icenko-Cushing's disease by peritol led to a decrease in the blood content of beta-endorphine and beta-lipotropin, promoting a clinical and laboratory remission in 60% of patients. Some patients treated with peritol did not develop a clinical remission. This indicates the necessity of acting on the metabolism of other monoamines involved in the modulation of the action of neuropeptides on the hypothalamus-pituitary system.
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003480:Cushing Syndrome / Q000097:blood* / Q000188:drug therapy; D003533:Cyproheptadine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004723:Endorphins / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced; D007328:Insulin; D008297:Male; D008875:Middle Aged; D008939:Mitotane / Q000627:therapeutic use*; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000097:blood*
chemical_list: D004723:Endorphins; D007328:Insulin; D003533:Cyproheptadine; D001615:beta-Endorphin; D008939:Mitotane; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin; D006854:Hydrocortisone
vernacular_title: Dinamika soderzhaniia beta-lipotropina i beta-éndorfina u bol'nykh bolezn'iu Itsenko-Kushinga pri lechenii antiserotonnovym preparatom tsiprogeptadinom (peritolom) i khloditanom.