title: Pharmacokinetics and pharmacodynamics of Org NC 45 in man.
abstract: A combined pharmacokinetic--pharmacodynamic study of Org NC 45 was performed in six patients undergoing elective oro--facial surgery. The pharmacokinetics could be described using a two-compartment open model with a distribution half-life of approximately 4 min and an elimination half-life of approximately 31 min. The pharmacokinetic parameters confirm earlier clinical findings that Org NC 45 has a more rapid onset and a shorter duration of action than pancuronium, and a faster recovery rate. When comparing the pharmacokinetic and pharmacodynamic parameters the biophase could be distinguished from both the central and the peripheral compartments. The mean steady-state plasma concentration producing a 50% block of the twitch response was 0.137 microgram ml-1 (range 0.118--0.176 microgram ml-1).
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D013997:Time Factors; D014673:Vecuronium Bromide
chemical_list: D014673:Vecuronium Bromide; D010197:Pancuronium