Studies on retinal microangiopathy and coronary macroangiopathy in rats with streptozotocin-induced diabetes.
Diabetes mellitus was induced in male rats by streptozotocin injection. After 4, 8 and 12 months, retinal and coronary vessels were prepared and their structure was studied. An age-dependent increase in thickness of the capillary basement membrane of retinal vessels was found both in controls and diabetics. Furthermore, diabetics had an added 20%, disease-related thickening, present after 4 months and thereafter. No significant change in coronary arteries was found. After 8 and 12 months, plasma lipids, triiodothyronin and thyroxin were measured. In diabetics, triglycerides were higher at both time intervals, high density lipoprotein was slightly increased and thyroxin was reduced after 8 months, and triiodothyronin was reduced after both 8 and 12 months. Diabetes of 12 months duration appears insufficient to induce significant arteriosclerotic changes in rats.
D000818:Animals; D001485:Basement Membrane; D003327:Coronary Disease / Q000473:pathology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000473:pathology*; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012171:Retinal Vessels / Q000473:pathology*; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014284:Triiodothyronine; D013974:Thyroxine