Increased levels of ADP ribosylation during cytomegalovirus replication in human embryo fibroblasts.
ADP ribosylation has been studied during human Cytomegalovirus (HCMV) replication in human embryo fibroblasts. The intranuclear level of this enzyme is higher during the whole viral replication cycle with respect to mock infected cells. The increase begins during the first hour ater the addition of the viral stock to the cells. Results are discussed in view of the possibility that this enhanced activity might be correlated with HCMV-induced alteration of the cell chromatin leading to an increase in host cell macromolecular synthesis.
D000246:Adenosine Diphosphate Ribose / Q000096:biosynthesis*; D000818:Animals; D002460:Cell Line; D003587:Cytomegalovirus / Q000502:physiology*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D051379:Mice; D009702:Nucleoside Diphosphate Sugars / Q000096:biosynthesis*; D014779:Virus Replication
D009702:Nucleoside Diphosphate Sugars; D000246:Adenosine Diphosphate Ribose