Reevaluation of C-reactive protein in cancer sera by radioimmunoassay and radial immunodiffusion. I. Diagnostic value and use in battery of conventional tumor markers.
C-reactive protein (CRP) has been found to be ubiquitous in sera when determined by a highly sensitive methods such as radioimmunoassay. Patients with some tumors appear to have much higher serum levels of CRP than others; in these, CRP seems to reflect the tumor burden. There is a positive correlation with TNM staging and the disease activity a the time of determination. CRP shows a high degree of 'uniqueness' when correlated with other routinely used cancer markers such as carcinoembryonic antigen, placental-like alkaline phosphatase and gamma-glutamyltranspeptidase.
D000469:Alkaline Phosphatase / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003110:Colonic Neoplasms / Q000097:blood; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D009369:Neoplasms / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood; D011863:Radioimmunoassay; D014594:Uterine Neoplasms / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D002272:Carcinoembryonic Antigen; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase