Abscesses following prolonged intramuscular administration of perphenazine enantate.
In an investigation of 109 patients on neuroleptics in a vegetable oil base, four of the patients developed abscesses at the site of deposits of perphenazine enantate given intramuscularly in large doses every 1-4 weeks. Observations suggested that the risk of such a complication could be minimized by limiting the frequency of administration to once a fortnight, by limiting the dose injected, by frequent variation of the site of injection, and by regular use of a disinfectant.
D000038:Abscess / Q000209:etiology*; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010546:Perphenazine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014677:Pharmaceutical Vehicles; D011618:Psychotic Disorders / Q000188:drug therapy*; D012715:Sesame Oil
D014150:Antipsychotic Agents; D014677:Pharmaceutical Vehicles; D012715:Sesame Oil; D010546:Perphenazine; C028675:perphenazine enanthate