Combined treatment with ranitidine and saline antacids prior to obstetric anaesthesia.
Ranitidine 150 mg was given to 126 patients requiring elective Caesarean section under general anaesthesia: 43 women had ranitidine alone, 43 had this supplemented by a pre-induction dose of sodium citrate and 40 patients had ranitidine plus sodium bicarbonate. All three sub-groups provided satisfactory gastric pH and volume. Ranitidine 150 mg was given orally every 6 hours to women in labour. Of 221 patients requiring general anaesthesia during labour, 103 women received 30 ml 0.3 M sodium citrate and 118 women, 20 ml of 8.4% sodium bicarbonate 10 minutes before induction of anaesthesia. In the citrate sub-group there was one patient with a gastric pH less than 2.5 (mean pH 6.2, SEM 0.13 range 2.1-8.4). In the bicarbonate sub-group the lowest gastric acidity was 3.8 (mean pH 8.3, SEM 0.11 range 3.8-9.83).
D000768:Anesthesia, General; D000773:Anesthesia, Obstetrical; D000863:Antacids / Q000627:therapeutic use*; D001639:Bicarbonates / Q000627:therapeutic use*; D002585:Cesarean Section; D002951:Citrates / Q000627:therapeutic use*; D019343:Citric Acid; D004359:Drug Therapy, Combination; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011247:Pregnancy; D011292:Premedication; D011899:Ranitidine / Q000627:therapeutic use*; D017693:Sodium Bicarbonate; D013997:Time Factors
D000863:Antacids; D001639:Bicarbonates; D002951:Citrates; D019343:Citric Acid; D011899:Ranitidine; D017693:Sodium Bicarbonate