Interaction between antidepressants and alpha-adrenergic receptor blocking agents.
Yohimbine and phentolamine administered in doses regarded as blocking presynaptic alpha-adrenoreceptors counteracted locomotor sedation elicited in rats by antidepressant drugs (imipramine, nortriptyline and amitriptyline). The reduction of noradrenaline (NA) utilization in the brain evoked by a single dose of antidepressants and the increase of NA utilization induced by chronic treatment with imipramine or nortriptyline were prevented by yohimbine. The results indicate the role of presynaptic alpha-adrenoceptors in the influence of tricyclic antidepressants on NA neurons in the brain.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000928:Antidepressive Agents; D011942:Receptors, Adrenergic, alpha; D009638:Norepinephrine