6-methoxy-tetrahydro-beta-carboline (pinoline): effects on plasma renin activity and aldosterone, TSH, LH and beta-endorphin levels in rats.
Plasma renin activity and the plasma concentrations of aldosterone, TSH, LH and beta-endorphin were radioimmunologically determined in rats after ip administration of 15 mg/kg of 6-methoxy-tetrahydro-beta-carboline (6-MeO-THBC, pinoline), a compound found to occur normally in mammalian and avian pineal gland. A 2.6-fold increase of plasma aldosterone concentration was found and it was preceded by increase of plasma renin activity. An increase was also found in beta-endorphin/beta-lipotrophin concentration while TSH and LH concentrations did not change significantly. The present results do not prove nor exclude the concept that 6-MeO-THBC is the 'adrenoglomerulotropin'. The effects of 6-MeO-THBC on plasma beta-endorphin/beta-lipotrophin levels may be mediated by the dopaminergic or 5-HT-neurones.
D000450:Aldosterone / Q000097:blood*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D004723:Endorphins / Q000097:blood*; D007211:Indoles / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects; D013972:Thyrotropin / Q000097:blood*; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000097:blood
D000927:Anticonvulsants; D002243:Carbolines; D004723:Endorphins; D007211:Indoles; C002272:6-methoxytryptoline; D000450:Aldosterone; D001615:beta-Endorphin; D007986:Luteinizing Hormone; D013972:Thyrotropin; D008083:beta-Lipotropin; D012083:Renin