Pharmacokinetic study of lorazepam overdosage.
The authors describe three patients who attempted to commit suicide by ingesting overdoses of lorazepam, an intermediate-acting benzodiazepine that, unlike diazepam, has no active metabolites. All three patients were clinically well within 24-30 hours of ingestion, although high lorazepam concentrations persisted. The authors point out that the elimination half-life of lorazepam after extremely high doses have been ingested is approximately the same as that found after ingestion of usual therapeutic doses.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000506:poisoning*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008140:Lorazepam / Q000097:blood / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D013406:Suicide, Attempted / Q000523:psychology
D014151:Anti-Anxiety Agents; D008140:Lorazepam