Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C.
In a multicentre trial of adjuvant chemotherapy in gastric adenocarcinoma, a number of patients developed chronic haemolysis and renal failure following long-term treatment with 5-fluorouracil and mitomycin-C. This was exacerbated by blood transfusion, leading to an acute intravascular haemolytic state accompanied by rapid decline in renal function. One patient investigated extensively was treated with antiplatelet drugs, steroids, and fresh frozen plasma without success. At necropsy this patient and another had renal changes typical of the haemolytic-uraemic syndrome and no evidence of tumour recurrence. Long-term treatment with this drug combination is potentially dangerous, and routine monitoring of renal function is recommended.
D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000748:Anemia, Macrocytic / Q000139:chemically induced*; D001929:Brain Edema / Q000139:chemically induced; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D008937:Mitomycins / Q000009:adverse effects*; D011654:Pulmonary Edema / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000188:drug therapy; D013997:Time Factors; D065227:Transfusion Reaction; D014511:Uremia / Q000139:chemically induced*
D008937:Mitomycins; D005472:Fluorouracil