Carcinogenic activities of hydroxymethyl derivatives of 4-(dimethylamino)azobenzene in the liver of rats, mice, and hamsters.
The carcinogenic activity of 3'-hydroxymethyl-N,N-dimethyl-4-aminoazobenzene (3'-CH2OH-DAB) was studied in Sprague-Dawley rats of both sexes, male ddy mice, and male Syrian golden hamsters. The activity of 2'-CH2OH-DAB and 4'-CH2OH-DAB was studied in male Sprague-Dawley rats. Azo dyes were given in the diet at a concentration of 0.064% for 3 months followed by a stock diet for 1 month; animals were sacrificed 4 months after beginning of the experiment. Liver hyperplastic nodules developed in all 8 male rats (100%) and in all 10 female rats (100%) which received 3'-CH2OH-DAB and in 7 out of 12 male rats (58%) which received 2'-CH2OH-DAB. Hepatocellular carcinomas were produced in 1 out of 8 male rats (13%) and in 1 out of 10 female rats (10%) receiving 3'-CH2OH-DAB. No hepatic lesions were observed in rats receiving 4'-CH2OH-DAB and in mice and hamsters receiving 3'-CH2OH-DAB. These results indicate that a carcinogenic effect of 3'-CH2OH-DAB and 2'-CH2OH-DAB could be detected in rats.
D000818:Animals; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000473:pathology; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D006965:Hyperplasia / Q000453:epidemiology; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D008749:Methyldimethylaminoazobenzene / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D004124:p-Dimethylaminoazobenzene / Q000031:analogs & derivatives*
D002273:Carcinogens; C032237:3'-hydroxymethyl-4-(dimethylamino)azobenzene; D008749:Methyldimethylaminoazobenzene; D004124:p-Dimethylaminoazobenzene