6 -Hydroxydopamine decreases benzodiazepine but not GABA receptor binding in rat cerebellum.
The noradrenergic innervation to the cerebellum was lesioned by intracerebroventricular 6-hydroxydopamine and the effects on GABA and benzodiazepine receptors followed by radiolabelling experiments. This lesion produced a 20% decrease in benzodiazepine receptor labelling in the cerebellum with no change in the labelling of GABA receptors. This provides further evidence for a lack of identity between the GABA and benzodiazepine receptors.
D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D005445:Flunitrazepam / Q000378:metabolism; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D011955:Receptors, Drug / Q000187:drug effects / Q000378:metabolism*; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology
D006892:Hydroxydopamines; D011956:Receptors, Cell Surface; D011955:Receptors, Drug; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D005680:gamma-Aminobutyric Acid; D005445:Flunitrazepam; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase