Dopamine receptors and the cardiovascular system.
The relatively high levels of dopamine compared with those of noradrenaline found in many tissues, together with the wide distribution of dopamine receptors in the periphery, suggest that the amine may have important physiological functions, and may act as a neurotransmitter in its own right. Compounds which selectively stimulate vascular and neuronal dopamine receptors, decrease vascular resistance in the mesenteric, renal and coronary vascular beds, inhibit sympathetic ganglionic transmission and decrease transmitter efflux from certain noradrenergic neurones may prove effective in the treatment of cardiovascular disease and serve, in addition, as useful pharmacological tools.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology; D002319:Cardiovascular System / Q000294:innervation*; D002415:Cats; D004285:Dogs; D004298:Dopamine / Q000502:physiology; D004558:Electric Stimulation; D005728:Ganglia, Sympathetic / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D001971:Bromocriptine; D011433:Propranolol; D004298:Dopamine