title: Life span elongation of Werner's syndrome fibroblasts by co-culture with origin-defective SV-40 DNA transformed cells.
abstract: Co-culturing with origin-defective SV40 DNA-injected transformants, we succeeded in activating the limited growth potential of late-phase-II fibroblasts from patients with Werner's syndrome (WS cells). Residual life spans of three WS cell lines increased 2.3-5.6 fold. Co-culture with normal IMR-90 cells showed variable effects on different WS cell lines.
mesh_terms: D000375:Aging; D002470:Cell Survival; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D004261:DNA Replication; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D010455:Peptides / Q000502:physiology; D013539:Simian virus 40; D015291:Transforming Growth Factors; D014898:Werner Syndrome / Q000473:pathology*
chemical_list: D006133:Growth Substances; D010455:Peptides; D015291:Transforming Growth Factors