title: [The antianaphylactic effect of derivatives of 4-oxoquinazoline, 4-oxoquinazol-3-yl-benzoic acid and 4-oxoquinazol-3-yl-acetic acid in the rat].
abstract: Derivatives substituted at position 2 of 4-oxochinazolin as well as derivates of oxochinazolin-3-yl-benzoic acid and 4-oxochinazolin-3-yl-acetic acid had been tested for their antianaphylactic activities in the passive (PCA) and/or active cutaneous anaphylaxis (ACA) in rats. At i.p. administration (ACA) or intracutaneous (i.c.) administration (PCA) most of the derivates displayed a moderate antianaphylactic activity which et best could be compared to the theophylline activity. Only the free acids of the 4-oxochinazolin-3-yl-acetic acid derivatives were active at i.c. administration. All compounds tested remained inactive at p.o. administration.
mesh_terms: D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology; D055598:Chemical Phenomena; D002621:Chemistry; D007700:Kinetics; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000494:pharmacology
chemical_list: D011799:Quinazolines; D013806:Theophylline
vernacular_title: Untersuchungen zur antianaphylaktischen Wirksamkeit von Derivaten des 4-Oxochinazolins, der 4-Oxochinazolin-3-yl-benzoesäure und der 4-Oxochinazolin-3-yl-essigsäure an der Ratte.