Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease.
The effect of prior incubation with a single concentration of isoproterenol (10(-4) M) for 2 hours at 37 degrees C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subjects groups prior incubation of cells with isoproterenol resulted in a significant reduction of cyclic AMP accumulation upon subsequent stimulation with isoproterenol.
D000262:Adenylyl Cyclases / Q000097:blood*; D000328:Adult; D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000201:enzymology*; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D011458:Prostaglandins E / Q000097:blood; D011943:Receptors, Adrenergic, beta / Q000097:blood*
D011458:Prostaglandins E; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol