Motilin release by intravenous infusion of nutrients and somatostatin in conscious dogs.
to investigate the regulatory mechanism of motilin release, plasma motilin was measured by radioimmunoassay in healthy dogs during the fasting state and after intravenous administration of various nutrients and somatostatin. The fasting plasma motilin levels of these dogs were found to fluctuate intermittently. Intravenous glucose loading lowered plasma motilin, but immediately after the end of the glucose infusion as abrupt rise of plasma motilin was observed. Mixed amino acids administered intravenously abruptly inhibited motilin secretion, and plasma motilin levels remained low even 45 min after the end of the infusion. On the other hand, no remarkable change in plasma motilin was noted after the fat infusion. Following somatostatin infusion, plasma motilin was significantly decreased, remaining low even 30 min after the end of the infusion. These observations led us to conclude than motilin secretion is regulated by somatostatin and by nutrients coming through intravenous routes.
D000596:Amino Acids / Q000008:administration & dosage*; D000818:Animals; D004285:Dogs; D005215:Fasting; D005768:Gastrointestinal Hormones / Q000097:blood*; D005947:Glucose / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D007700:Kinetics; D009037:Motilin / Q000097:blood*; D013004:Somatostatin / Q000008:administration & dosage*
D000596:Amino Acids; D005768:Gastrointestinal Hormones; D013004:Somatostatin; D009037:Motilin; D005947:Glucose