[Lack of viral persistence in 2 Cebus sp].
Two Cebus sp surviving acute Junin virus infection, one after intramuscular inoculation with pathogenic XJ and the other after intracerebral inoculation with XJ Clone 3, failed to exhibit persistent infection. Although treatment with immunosuppressive drugs was carried out, no Junin virus was detected in blood or organs in spite of blind passages in mice for the former as well as cocultivation with permissive Vero cells for the latter. Viremia was also ruled out by immunofluorescence on BHK/21 cell culture. These findings correlate with the lack of long-lasting virus in blood observed in humans following the acute phase of Argentine Hemorrhagic Fever.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001116:Arenaviridae / Q000502:physiology*; D006477:Arenaviruses, New World / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology*; D002427:Cebidae / Q000382:microbiology*; D002428:Cebus / Q000382:microbiology*; D003289:Convalescence; D005260:Female; D006478:Hemorrhagic Fever, American / Q000382:microbiology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice
D000956:Antigens, Viral; D007166:Immunosuppressive Agents
Falta de persistencia del virus en dos Cebus sp.