title: Is glucagon a choleretic hormone at physiologic blood levels?
abstract: The mechanism of action and possible physiologic implications of glucagon-induced choleresis were investigated in two groups of dogs. Group I demonstrated, in chronic animal models, that glucagon-induced choleresis was not associated with increased bile acid output and was not blocked by somatostatin or Piptal, suggesting a direct stimulatory effect on bile acid-independent canalicular flow. In acute animal models (group II), glucagon infusion at rates which produced postprandial levels in the portal vein induced significant choleresis, implying that glucagon may have a physiologic role in the regulation of bile secretion. No consistent relation between bile secretion and portal venous blood flow could be demonstrated.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D004285:Dogs; D004896:Erythritol / Q000378:metabolism; D005260:Female; D005934:Glucagon / Q000097:blood / Q000502:physiology*; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D011169:Portal Vein / Q000502:physiology; D012039:Regional Blood Flow; D013004:Somatostatin / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D001639:Bicarbonates; D001647:Bile Acids and Salts; D010276:Parasympatholytics; D013004:Somatostatin; D005934:Glucagon; D000469:Alkaline Phosphatase; D004896:Erythritol