Comparative study of ceftriaxone and cefuroxime for perioperative prophylaxis in orthopedic surgery.
The results of perioperative prophylaxis with either ceftriaxone or cefuroxime have been compared in a nonrandomized trial in 60 patients undergoing orthopedic surgery. A 2 g dose of ceftriaxone was given intravenously 15 minutes before surgery and repeated 24 hours after surgery in 29 patients. One patient with renal insufficiency received 1 g doses of ceftriaxone. The other 30 patients received a 1.5 g dose of cefuroxime given intravenously 15 minutes before surgery and repeated every 6 hours for 48 hours after surgery. In one of the 30 patients given cefuroxime, a postoperative infection due to Staph. aureus developed in association with a hematoma, which resolved after surgical debridement and drainage; treatment was continued with cefuroxime. No postoperative infection developed in any of the patients who received ceftriaxone. Both antibiotics were well tolerated locally and systemically.
D000328:Adult; D000368:Aged; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002443:Ceftriaxone; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D017053:Infection Control; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D011183:Postoperative Complications / Q000517:prevention & control; D012306:Risk; D014945:Wound Healing / Q000187:drug effects
D002511:Cephalosporins; D002443:Ceftriaxone; D002439:Cefotaxime; D002444:Cefuroxime