Mathematical model of synaptic plasticity: III. Heterosynaptic changes.
A mathematical model, using differential equations, of heterosynaptic plasticity is proposed. The model is based on physiological studies of invertebrates in which nonspecific conditioning, such as sensitization and heterosynaptic inhibition, starts to be elucidated and behavioral studies of classical and instrumental conditioning, which we postulate to have the same mechanisms as those found in nonspecific conditioning. The model permits us to simulate the following heterosynaptic changes: sensitization, heterosynaptic inhibition, classical and instrumental conditioning--including short- and long-term memory--extinction and recuperation--spontaneously and by stimulation.
D000818:Animals; D001048:Aplysia; D003201:Computers; D003213:Conditioning, Psychological / Q000502:physiology*; D008433:Mathematics; D008959:Models, Neurological; D009433:Neural Inhibition; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission