title: Treatment of pruritus of cholestasis by plasma perfusion through USP-charcoal-coated glass beads.
abstract: The accumulation of bile acids has been implicated in the pathogenesis of pruritus of cholestasis. To study the effect of bile-acid depletion on pruritus, 8 patients with chronic cholestasis and intractable pruritus which had not responded to cholestyramine and/or phenobarbitone underwent plasma perfusion through USP-charcoal-coated glass beads. DSuring twenty-two perfusions, between 957 and 6100 ml of plasma were perfused through charcoal columns, resulting in the removal of 126-795 mumol of bile acids. The mean extraction of the perfused bile acids was 81%. After the perfusions, all patients had prompt relief of their pruritus, lasting from 24 h to 5 months. Although the clinical effect may be due to the removal of unidentified pruritogens other than bile acids, charcoal plasma perfusion may improve the quality of life of incapacitated patients with servere intractable pruritus of cholestasis.
mesh_terms: D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000032:analysis / Q000097:blood*; D002606:Charcoal; D002779:Cholestasis / Q000150:complications*; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010602:Pharmacopoeias as Topic; D011537:Pruritus / Q000209:etiology / Q000628:therapy*; D012867:Skin / Q000032:analysis; D014481:United States
chemical_list: D001647:Bile Acids and Salts; D002606:Charcoal