The prediction of the bulk densities of powder mixtures, and its relationship to the filling of hard gelatin capsules.
From measurements of the properties of individual components, it has been found possible to predict the maximum tapped bulk density of two component mixtures of a range of particle size fractions of acetylsalicylic acid and lactose in varying proportions. This has been extended to the prediction of bulk density of such mixtures when filled into hard gelatin capsules by a system which results in the powders existing at the maximum tapped bulk density. Consequently the capsule fill weight can also be predicted for such systems. The method is less satisfactory for the prediction of the bulk density and capsule fill weight, when the capsules are filled by a process involving compression of the powder within the capsule shell.
D001241:Aspirin; D002214:Capsules; D004339:Drug Compounding; D005780:Gelatin; D007785:Lactose; D010316:Particle Size; D011208:Powders
D002214:Capsules; D011208:Powders; D005780:Gelatin; D007785:Lactose; D001241:Aspirin