title: Theoretical and clinical aspects of the Tourette syndrome (chronic multiple tic).
abstract: In three schizophrenic patients long-term neuroleptic treatment induced Tourette-like symptoms. There seems to be a partial overlap in the pathogenesis of Tourette syndrome and tardive dyskinesia. In five Tourette patients treatment with pimozide was very effective inducing only few side-effects. Long-term neuroleptic treatment may, however, aggravate the symptoms in the long run. A combination treatment with tetrabenazine and pimozide is suggested.
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010868:Pimozide / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy*; D005879:Tourette Syndrome / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D010868:Pimozide