title: Modelling the ATP-binding site of oncogene products, the epidermal growth factor receptor and related proteins.
abstract: A three-dimensional model for the ATP-binding site of the oncogene product v-src is proposed by the use of interactive computer graphics. A similar model would apply to sequence related proteins such as other oncogene products, the epidermal growth factor receptor, cAMP-dependent protein kinase and the cell division control protein CDC28. The model was proposed on the basis of the conservation of certain key residues between the oncogene product family of proteins and several nucleotide binding proteins of known structures.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004798:Enzymes / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008958:Models, Molecular; D009243:NAD / Q000378:metabolism; D015688:Oncogene Protein pp60(v-src); D009857:Oncogenes; D011485:Protein Binding; D011487:Protein Conformation; D011494:Protein Kinases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D004798:Enzymes; D011956:Receptors, Cell Surface; D014764:Viral Proteins; D009243:NAD; D004815:Epidermal Growth Factor; D000255:Adenosine Triphosphate; D005954:Glucosephosphate Dehydrogenase; D011494:Protein Kinases; D066246:ErbB Receptors; D015688:Oncogene Protein pp60(v-src)