Respiratory effects of a new opiate analgesic, R 39209, in the rabbit: comparison with fentanyl.
The respiratory effects of R 39209, a new short-acting analgesic, were studied and compared with those of fentanyl, in the rabbit. Minute volume, respiratory frequency and pH, PCO2 and standard bicarbonate of arterialized venous blood were measured. R 39209 had an earlier peak effect and shorter duration of action then fentanyl, but otherwise the respiratory effects of the two-drugs were similar. Fentanyl was between 2 and 3.5 times more potent than R 39209. Repeated doses of R 39209 produced reproducible peak effects even when only 10 min was allowed between administrations.
D015760:Alfentanil; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007700:Kinetics; D008176:Lung Volume Measurements; D010313:Partial Pressure; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*
D000701:Analgesics, Opioid; D002245:Carbon Dioxide; D015760:Alfentanil; D005283:Fentanyl