Influence of chronic lithium administration on binding to benzodiazepine- and histamine H1-receptors in rat brain.
In rat, chronic lithium treatment lowered the Kd of [3H]-mepyramine in midbrain, and reduced the Bmax in midbrain and pons-medulla. Binding of [3H]flunitrazepam in cerebellum and midbrain was not altered. The suggestion that some actions of lithium may occur by way of central nervous system receptors is further supported by these observations that lithium's effects on neurotransmitter systems are regional and specific.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology*; D011738:Pyrilamine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects* / Q000378:metabolism
D011963:Receptors, GABA-A; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D005445:Flunitrazepam; D008094:Lithium; D011738:Pyrilamine