The in vivo and in vitro degradation of poly(glycolic acid) suture material as a function of applied strain.
The in vivo and in vitro stability of a degradable suture material, poly(glycolic acid) has been shown to be dependent on the magnitude of a pre-imposed strain. The degradation, monitored by changes in the tensile load at break, was considerably enhanced by pre-straining the material to one half of the normal extension at break, using a novel implantable device.
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D011100:Polyglycolic Acid / Q000378:metabolism; D011817:Rabbits; D013314:Stress, Mechanical; D013537:Sutures; D013718:Tensile Strength
D001672:Biocompatible Materials; D011100:Polyglycolic Acid