In-vitro calcium uptake by jejunal biopsy specimens from patients with idiopathic hypercalciuria.
In-vitro calcium influx was measured in jejunal biopsy specimens from 10 men with idiopathic hypercalciuria. Calcium uptake in these adults was a passive process which was not sensitive to inhibition by 2,4 dinitrophenol and sodium fluoride, and showed no evidence of carrier saturation. In 7 of 10 patients with idiopathic hypercalciuria calcium uptake was above the normal range, and the mean uptake for all patients was significantly higher than in 10 control subjects (p < 0.01). The kinetic features suggest that this increased influx was the result of increased brush border permeability to calcium ions.
D000328:Adult; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism* / Q000652:urine*; D002462:Cell Membrane / Q000378:metabolism*; D002463:Cell Membrane Permeability; D006801:Humans; D007583:Jejunum / Q000378:metabolism* / Q000648:ultrastructure; D007669:Kidney Calculi / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008871:Microvilli / Q000378:metabolism*
D002118:Calcium