Intracellular flow of particulate steroid-receptor complexes in steroid target cells.
The structural expression of nuclear transportation of receptor-bound oestradiol was investigated by immunoelectron microscopy on human breast cancer cells. In oestradiol-treated cells during transportation, oestradiol antibodies attached to cytoplasmic oestradiol-bearing particles which seemed to interact with the nuclear membrane. These particles, subserving the intracellular flow of steroid-receptor complexes, could constitute a special cellular system of macromolecular transport, communication and compartmentalisation.
D000906:Antibodies / Q000032:analysis; D001692:Biological Transport; D001943:Breast Neoplasms / Q000032:analysis*; D003593:Cytoplasm; D004958:Estradiol; D005260:Female; D006801:Humans; D009685:Nuclear Envelope / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis*
D000906:Antibodies; D011960:Receptors, Estrogen; D004958:Estradiol