[The role of cyclic nucleotides in the development of resistance to metastases after treatment with immunomodulators].
It is shown that zymosan, prodigiosan, tiloron and levamisol have a different effect on the level of cyclic nucleotides and the cAMP/cGMP correlation in the lungs, thymus and spleen of mice during metastatic spreading of the Lewis carcinoma. A more pronounced antimetastatic effect after administration of immunomodulators is accompanied by a more considerable increase in the cAMP/cAMP coefficient in immunocompetent organs. There exists a close negative correlation between the increase in the cAMP/cGMP coefficient in the thymus and spleen, on the one hand, and inhibition of the metastatic spreading in the lungs under the effect of levamisol and zymosan, on the other.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000242:Cyclic AMP; D006152:Cyclic GMP
Uchastie tsiklicheskikh nukleotidov v formirovanii soprotivliaemosti organizma razvitiiu metastazov pod vliianiem immunomoduliatorov.