title: Nonsurgical female sterilization.
abstract: The development of a safe, effective nonsurgical method of female sterilization that can be performed by paramedical personnel remains a high priority. The method should have a blind delivery system and require only one application. Methyl cyanoacrylate and quinacrine hydrochloride are the two most promising chemical agents. Quinacrine has evolved from instillations of a solution to the development of pellets to the use of an IUD vector. By using an IUD vector to deliver the quinacrine, tubal occlusion can be achieved with a reduction in total dosage and with one insertion instead of the three necessary with the solution and pellet methods.
mesh_terms: D000818:Animals; D003487:Cyanoacrylates / Q000494:pharmacology*; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D007435:Intrauterine Devices, Copper; D008722:Methods; D011247:Pregnancy; D011796:Quinacrine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D003487:Cyanoacrylates; D011796:Quinacrine