title: The K+ liquid ion exchange electrode system: responses to drugs and neurotransmitters.
abstract: K+-sensitive liquid ion exchange electrode systems respond with a slow potential change to acetylcholine, choline, anticholinergic drugs, biogenic amines, and glutamic acid. The response threshold has been defined, and in most cases it is at extremely low concentrations (10(-7)-10(-5)M). The direction of the potential change varies, but in most instances it is additive to that produced by external K+. The K+ electrode system is further sensitive to decreasing pH, within a narrow and possibly physiological range of pH. These findings suggest that small measured changes in extracellular K+ are biased by the chemosensitivity of the liquid ion exchange electrode system to some compounds of physiological importance.
mesh_terms: D000109:Acetylcholine; D001285:Atropine; D002794:Choline; D004566:Electrodes; D005971:Glutamates; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine; D011188:Potassium; D011199:Potentiometry; D011433:Propranolol; D012701:Serotonin; D013566:Sympathomimetics; D014403:Tubocurarine; D014439:Tyramine / Q000031:analogs & derivatives
chemical_list: D005971:Glutamates; D018377:Neurotransmitter Agents; D013566:Sympathomimetics; D012701:Serotonin; D001285:Atropine; D011433:Propranolol; D002794:Choline; D000109:Acetylcholine; D011188:Potassium; C008510:O-methyltyramine; D014403:Tubocurarine; D009638:Norepinephrine; D014439:Tyramine