title: The new histamine H2-receptor antagonist ranitidine. Duration of action.
abstract: The antisecretory effects of a new histamine H2-receptor antagonist ranitidine hydrochloride 150 mg, have been tested on basal and pentagastrin-stimulated acid secretion in healthy volunteers 5 and 10 h after oral administration. In addition, the 24 h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition after three oral doses of ranitidine 150 mg per day. A significant inhibition of basal acid output has been observed up to 10 h after the drug. The intragastric pH remained above 5 for at least 24 h. Ranitidine has proven to be a more potent and longer acting antisecretory compound than cimetidine.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005663:Furans / Q000008:administration & dosage / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D011899:Ranitidine; D013997:Time Factors
chemical_list: D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D010418:Pentagastrin