Kidney function in patients with affective disorders with and without lithium therapy.
The ability to concentrate the urine was estimated in healthy volunteers, patients with affective disorders who had never received lithium and lithium-treated patients. Patients with affective disorders who had never received lithium were found to have significantly lower concentrating capacity than healthy volunteers. However, lithium-treated patients had still lower concentrating capacity and differed significantly both from healthy volunteers and from patients who had never received lithium. Furthermore, in a subgroup of lithium-treated patients investigated twice with an interval of 6 months, a progressive decrease in concentrating capacity was found, indicating the importance of lithium therapy.
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000188:drug therapy* / Q000503:physiopathology; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000009:adverse effects; D001714:Bipolar Disorder / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007671:Kidney Concentrating Ability / Q000187:drug effects; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D008094:Lithium