title: Alterations of plasma high-density lipoprotein cholesterol levels associated with consumption of selected medications. The Lipid Research Clinics Program Prevalence Study.
abstract: From the 10 North American study populations of the Lipid Research Clinics Program, mean levels of plasma high-density (HDL) cholesterol were contrasted between users of eight categories of prescribed medications and a control group of nonusers of those categories matched for age, sex, study population and ponderosity. Women taking propranolol had a mean HDL cholesterol level 12 mg/dl lower than nonusers (p < 0.05). Men taking phenytoin had a mean HDL cholesterol level more than 18 mg/dl higher than nonusers (p < 0.05). Men taking benzodiazepine derivatives had a mean HDL cholesterol level 3.3 mg/dl lower than nonusers (p < 0.05). No significant differences were found between users and nonusers of thiazide diuretics, chlorthalidone, barbiturates, sympathomimetics or antihistamines.
mesh_terms: D001463:Barbiturates / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D001581:Benzothiadiazines; D002752:Chlorthalidone / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood*; D004232:Diuretics; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use; D013566:Sympathomimetics / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
chemical_list: D001463:Barbiturates; D001581:Benzothiadiazines; D004232:Diuretics; D006634:Histamine H1 Antagonists; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D049993:Sodium Chloride Symporter Inhibitors; D013566:Sympathomimetics; D014280:Triglycerides; D001569:Benzodiazepines; D010672:Phenytoin; D002784:Cholesterol; D011433:Propranolol; D002752:Chlorthalidone