Inhibition of histamine-induced gastric secretion by flavone-6-carboxylic acids.
Twenty-five flavone-6-carboxylic acids were synthesized and tested as to their ability to inhibit histamine-induced gastric acid secretion in the rat. 3-Isopropoxy-4'-methoxyflavone-6-carboxylic acid (41) showed consistent oral activity while being devoid of any other noteworthy pharmacological effects. In vitro, this compound was found to be inactive as a histamine H2 antagonist, and its mode of action remains unknown.
D000818:Animals; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D005750:Gastric Juice / Q000378:metabolism*; D006633:Histamine Antagonists / Q000138:chemical synthesis*; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
D005419:Flavonoids; D006633:Histamine Antagonists; D006635:Histamine H2 Antagonists