Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines.
A simple model system for the behavioral actions of benzodiazepines is analyzed for its dose-response predictiveness, using several benzodiazepines, and for its pharmacological specificity, using other non-anxiolytic classes of psychoactive drugs. The model demonstrates an increase in mouse exploratory activity between a brighty-lit open field and a small, dark compartment by clonazepam, diazepam, flurazepam, chlordiazepoxide and meprobamate, but not by the peripheral benzodiazepine R05-4864, nor by clorgyline, butriptyline, or chlorpromazine.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines; D002746:Chlorpromazine / Q000494:pharmacology; D003010:Clorgyline / Q000494:pharmacology; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D008620:Meprobamate / Q000494:pharmacology; D051379:Mice; D008960:Models, Psychological; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D003986:Dibenzocycloheptenes; D001569:Benzodiazepines; D008620:Meprobamate; D010424:Pentobarbital; D003010:Clorgyline; D002746:Chlorpromazine; C100242:butriptyline