Identification of mephenytoin metabolites in the dog.
In two dogs p-hydroxymephenytoin, m-hydroxymephenytoin, 5-ethyl-5-phenylhydantoin (nirvanol), and 5-ethyl-5-(p-hydroxyphenyl)hydantoin (p-hydroxynirvanol) were identified by use of synthetic metabolites as standards for comparison.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005260:Female; D006827:Hydantoins / Q000652:urine*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008617:Mephenytoin / Q000031:analogs & derivatives / Q000652:urine*
D006827:Hydantoins; C014544:ethylphenylhydantoin; C025687:4-hydroxymephenytoin; C025688:4-hydroxynirvanol; C025686:3-hydroxymephenytoin; D008617:Mephenytoin