Treatment of chronic ulceration of the legs with human amnion.
Chronic leg ulcers in fifteen patients were prepared for autografting with a dressing of cultured human amnion. In thirteen vascular responses filled the ulcer beds with granulation tissue. Four patients initially received more traditional therapy and their lesions altered little in gross appearance and were not regarded clinically to have produced a granulation-tissue response. Fourteen patients received autografts after 5 days of amnion application and eight of these grafts have remained intact for 2-10 months. The appearance of healthy granulation tissue after amnion application was associated with successful autografting.
D000328:Adult; D000368:Aged; D000650:Amnion; D001458:Bandages; D002908:Chronic Disease; D005260:Female; D006097:Granulation Tissue / Q000502:physiology; D006801:Humans; D007871:Leg Ulcer / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011300:Preoperative Care / Q000379:methods; D016038:Skin Transplantation; D013997:Time Factors; D014182:Transplantation, Autologous; D014945:Wound Healing