[Effect of microapplications of cholecystokinin octapeptide on neurons of the dorsal hippocampus of alert rabbits].
The hormonally active fragment of the intestinal hormone cholecystokinin applied microiontophoretically or under pressure to the hippocampal neurons (fascia dentata and CA3 field) more or less depressed their spontaneous firing rate depending on the dosage. The neurons sensitivity to L--glutamate did not essentially change, at that. Neurons with burst--like firing started to reveal a regular patterns of firing. These data suggest an important role of the cholecystokinin octapeptide in central mechanisms of positive reinforcement.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002682:Chinchilla; D002766:Cholecystokinin / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D006624:Hippocampus / Q000187:drug effects*; D007478:Iontophoresis; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits; D012844:Sincalide
D018691:Excitatory Amino Acid Antagonists; D010446:Peptide Fragments; D018698:Glutamic Acid; D002766:Cholecystokinin; D012844:Sincalide
Vliianie mikroapplikatsiĭ oktapeptida kholetsistokinina na neĭrony dorsal'nogo gippokampa u bodrstvuiushchikh krolikov.