title: Inhibition of cyclic AMP-mediated intestinal hypersecretion by pituitary extracts from rats pretreated with cholera toxin.
abstract: Peroral pretreatment with cholera toxin (CT) in rats induced protection against intestinal hypersecretion by CT or prostaglandin E1 (PGE1). Pituitary glands from these CT-pretreated rats were homogenized and injected intravenously or intraluminally into untreated rats. These recipients became resistant to CT- as well as to PGE1-induced hypersecretion; recipients given pituitary extracts from control animals responded normally. Extracts of intestinal mucosa from CT-pretreated, but not from control rats, also inhibited secretion by CT. Ultrafiltration experiments with the pituitary or intestinal extracts indicated that the antisecretory factors had a molecular weight between 10,000 and 50,000.
mesh_terms: D000527:Alprostadil; D000818:Animals; D002772:Cholera Toxin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D010902:Pituitary Gland / Q000032:analysis*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D011458:Prostaglandins E; D014020:Tissue Extracts; D002772:Cholera Toxin; D000242:Cyclic AMP; D000527:Alprostadil