Cefotaxime in the cerebrospinal fluid and serum in patients with purulent meningitis.
Cefotaxime concentrations in the cerebrospinal fluid and serum were determined in patients with purulent meningitis by means of a simple, rapid and reproducible method in agar medium. The CSF concentrations of cefotaxime fluctuated around 4 mg/l. The pharmacokinetics of the antibiotic in relation to the integrity of the blood-brain barrier was studied by means of an assay of the albumin and IgG present in the cerebrospinal fluid and in the serum.
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism*; D002439:Cefotaxime / Q000134:cerebrospinal fluid / Q000378:metabolism*; D002648:Child; D006801:Humans; D008581:Meningitis / Q000188:drug therapy / Q000378:metabolism*; D008875:Middle Aged
D002439:Cefotaxime