The kinetics of somatostatin inhibition of gastric acid secretion.
The inhibitory effects of somatostatin on gastric acid secretion have been studied in dogs equipped with a gastric fistula. Somatostatin was a strong inhibitor of pentagastrin-stimulated acid secretion and appeared to act in a non-competitive manner. However, it was a weak inhibitor of histamine-stimulated acid secretion and in this case appeared to act in a competitive manner.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007700:Kinetics; D010418:Pentagastrin / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin; D006632:Histamine; D010418:Pentagastrin