Single-dose ceftriaxone versus multi-dose cefotaxime as short-term antimicrobial prophylaxis in urologic surgery. Preliminary results of a multicenter prospective randomized study.
This controlled multicenter study on 407 evaluable patients demonstrates the equal efficacy of two short-term antimi crobial prophylactic regimens in urological surgery involving a single dose of a long-acting cephalosporin, ceftriaxone, in comparison with a multiple dose of cefotaxime. Fifty-three of the 196 patients (27%) on the cefotaxime regimen and 47 of the 211 patients (22.3%) who received ceftriaxone showed postoperative infectious complications. There were no differences in these results.
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control*; D002439:Cefotaxime / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D002443:Ceftriaxone; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D014546:Urinary Catheterization / Q000009:adverse effects; D014551:Urinary Tract / Q000601:surgery*
D002443:Ceftriaxone; D002439:Cefotaxime