title: Multicenter double-blind efficacy and safety study comparing alprazolam, diazepam and placebo in clinically anxious patients.
abstract: Both alprazolam and diazepam were superior to placebo for the treatment of the clinical anxiety syndrome throughout a four-week double-blind multiclinic trial in 976 outpatients. At the fourth-week evaluation of the 845 patients completing the study, the 326 patients receiving alprazolam showed significantly more improvement than the 344 patients receiving diazepam on all 4 anxiety rating scales utilized (Hamilton Anxiety Rating Scale, Physician's Global Assessment, Patient's Global Assessment, and Target Symptoms).
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000525:Alprazolam; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy*; D001569:Benzodiazepines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D010919:Placebos; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D010919:Placebos; D001569:Benzodiazepines; D003975:Diazepam; D000525:Alprazolam