Neurotransmitter receptor binding in bovine cerebral microvessels.
Purified preparations of microvessels from bovine cerebral cortex contain substantial levels of alpha-adrenergic, beta-adrenergic, and histamine 1 receptor binding sites but only negligible serotonin, muscarinic cholinergic, opiate, and benzodiazepine receptor binding. Norepinephrine and histamine may be endogenous regulators of the cerebral microcirculation at the observed receptors.
D000818:Animals; D001921:Brain / Q000098:blood supply*; D002417:Cattle; D008024:Ligands; D008833:Microcirculation; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism
D008024:Ligands; D018377:Neurotransmitter Agents; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011985:Receptors, Serotonin