[Radiation-protective effectiveness of ATP and adenosine against high-energy protons].
The radioprotective effect of ATP and adenosine was investigated on CBA and C57Bl mice hybrids F1 irradiated with 9 GeV protons. The prophylactic treatment of the animals with ATP at a dose of 350-700 mg/kg increased their survival to 63-80% for LD78-83/30 (7.5-8.0 Gy) and to 40% for LD96/30 (8.5 Gy). The administration of adenosine at a dose of 340 mg/kg, equimolar to 700 mg/kg ATP, increased their survival to 93-100% and 73%, respectively. It was found that ATP produced a favorable effect on the hemopoiesis of irradiated mice.
D000241:Adenosine / Q000627:therapeutic use*; D000255:Adenosine Triphosphate / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D006410:Hematopoiesis / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011522:Protons; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000517:prevention & control*; D011835:Radiation Protection; D011837:Radiation-Protective Agents
D011522:Protons; D011837:Radiation-Protective Agents; D000255:Adenosine Triphosphate; D000241:Adenosine
Radiozashchitnaia effektivnost' ATF i adenozina pri vozdeistvi protonov vysokikh energiĭ.