Calmodulin and malignant hyperpyrexia.
The function of calmodulin as a biological regulator is linked to the level of free Ca2+ in the cell, and there is evidence that calmodulin may itself be involved in the control of the movements of cellular Ca2+. Malignant hyperpyrexia, on the other hand, is caused by a disturbance in the level of myoplasmic Ca2+. We have investigated the possibility that calmodulin may be involved in malignant hyperpyrexia by studying the trifluoperazine-induced inhibition of calmodulin activation by phosphodiesterase, using crude and purified calmodulin preparations from control and MH-susceptible pigs. No abnormality was found in the pattern of either calmodulin activation or trifluoperazine-induced inhibition in MH muscle.
D000818:Animals; D001923:Brain Chemistry; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000502:physiology*; D004789:Enzyme Activation / Q000187:drug effects; D008305:Malignant Hyperthermia / Q000201:enzymology / Q000209:etiology*; D009132:Muscles / Q000201:enzymology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D013552:Swine; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D014268:Trifluoperazine; D010727:Phosphoric Diester Hydrolases