A saturable binding site for high density lipoprotein3 on human liver membranes.
The binding of High Density Lipoprotein3 (HDL) to human liver membranes obtained from male normolipemic subjects was studied. High Density Lipoprotein3 binds in a specific, saturable manner to liver membranes; furthermore, this binding site appears to be distinct from these previously described for Low Density Lipoprotein (LDL) and chylomicron remnants. Competition experiments using Apo A-I reconstituted lipoproteins suggest that Apo A-I could be the determinant of the binding.
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000378:metabolism; D001665:Binding Sites; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007700:Kinetics; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008297:Male; D008566:Membranes / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D007457:Iodine Radioisotopes; D008055:Lipids; D008075:Lipoproteins, HDL; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D011956:Receptors, Cell Surface