title: Off-pathway synaptic transmission in the outer retina of the axolotl is mediated by a kainic acid-preferring receptor.
abstract: Intracellular recordings were made from OFF-centre bipolar cells and horizontal cells in the superfused axolotl retina eyecup preparation. Bath-applied (+/-)cis-2,3-piperidine dicarboxylic acid (PDA), gamma-D-glutamylglycine (DGG), L-glutamic acid diethyl ester (GDEE), (+/-)2-amino-5-phosphonovaleric acid (2-APV) and magnesium ions were assessed as antagonists of the actions of the photoreceptor transmitter. The rank order of antagonist efficacy was PDA greater than DGG greater than greater than 2-APV = GDEE = Mg2+. The results indicate that transmission at OFF-pathway synapses in the outer retina of the axolotl is mediated by a kainic acid-preferring receptor.
mesh_terms: D000557:Ambystoma; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology; D066298:In Vitro Techniques; D009474:Neurons / Q000502:physiology; D010786:Photoreceptor Cells / Q000502:physiology; D010875:Pipecolic Acids / Q000494:pharmacology; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D004151:Dipeptides; D010875:Pipecolic Acids; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter; C028929:gamma-glutamylglycine; C029262:2,3-piperidinedicarboxylic acid