Ultra-low dose intravenous heparin in the prevention of postoperative deep-vein thrombosis.
Heparin (1 IU kg-1 h-1) given intravenously for 3-5 days during and after operation in a double-blind randomised study, significantly reduced the frequency of deep-vein thrombosis detected by 125I-fibrinogen uptake, and pulmonary embolism. 22% (11/50) control patients and 4% (2/45) patients receiving heparin had deep-vein thrombosis or pulmonary embolism. Heparin administration was not associated with any increase in preoperative or postoperative bleeding.
D000368:Aged; D002769:Cholelithiasis / Q000601:surgery; D002986:Clinical Trials as Topic; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000601:surgery; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D007417:Intestinal Polyps / Q000601:surgery; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000517:prevention & control*; D012107:Research Design; D013924:Thrombophlebitis / Q000453:epidemiology / Q000517:prevention & control*
D006493:Heparin