[Effect of psychotropic substances and narcotic analgesics on 14C-noradrenaline uptake by rat cerebral cortex synaptosomes].
The effect of different groups of neurotropic substances was studied on labeled noradrenaline and gamma-aminobutyric acid (GABA) uptake by synaptosomes of the rat brain cortex. It has been shown that each group of the test compounds is characterized by specific qualitative and quantitative features of the action on the above processes. Thus, psychostimulants actively inhibit noradrenaline uptake without changing GABA uptake. On the contrary, neuroleptics exert a pronounced inhibitory effect on GABA uptake and insignificantly inhibit noradrenaline accumulation. Antidepressants are very potent while narcotic analgesic drugs are less potent inhibitors of the accumulation of both neuromediators. Morphine and nalorphine have no effect on these processes.
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects*; D013997:Time Factors
D000701:Analgesics, Opioid; D002250:Carbon Radioisotopes; D011619:Psychotropic Drugs; D009638:Norepinephrine
Vliianie psikhotropnykh veshchestv i narkoticheskikh anal'getikov na zakhvat noradrenalina-14C sinaptosomami kory mozga krys.