[Pharmacologic analysis of the physiologic mechanisms of the hemodynamics of orthostatic tolerance].
In urethane anesthesized rats, securinine brought about a distinct increase in compensatory reactions of arterial pressure and cardiac output during an upright tilt at 45 degrees. The experiments also showed a substantial increase in compensatory recovery of the volume velocity of circulation in the posterior vena cava. Myorelaxant induced arrest of contractile function of skeletal muscles prior to securinine administration reversed compensatory reactions of arterial pressure and cardiac output during tilt test.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001381:Azepines; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002415:Cats; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002496:Central Venous Pressure / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D009119:Muscle Contraction; D010880:Piperidines; D010946:Plants, Medicinal; D011187:Posture
D000470:Alkaloids; D001381:Azepines; D000697:Central Nervous System Stimulants; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D010880:Piperidines; C000785:securinine
Farmakologicheskiĭ analiz fiziologicheskikh mekhanizmov ortostaticheskoĭ ustoichĭvosti gemodinamiki.