Somatostatin facilitates the serotonin release from rat cerebral cortex, hippocampus and hypothalamus slices.
The effect of somatostatin on the release of serotonin (5-HT) from the superfused slices of rat cerebral cortex, hippocampus and hypothalamus preloaded with [3H]5-HT was examined. Somatostatin (0.38--1.53 microM) was found to facilitate dose-dependently the electrically- or high K+-stimulated release of [3H]5-HT. The order of the stimulatory potency of somatostatin on the evoked release in the 3 areas of the brain was cortex, hippocampus greater than hypothalamus.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects*; D046508:Culture Techniques; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology*
D012701:Serotonin; D013004:Somatostatin; D002118:Calcium