Migraine: a platelet disorder.
The hypothesis that migraine is caused by a primary abnormality of platelet behaviour was investigated in a total of 77 migraine patients and control subjects. Platelets taken from patients with classical migraine during a headache-free period demonstrated significantly higher spontaneous platelet aggregation and platelet adhesion than platelets from controls. Platelet 5-hydroxytryptamine release within three days of a migraine attack was significantly less than that measured during a migraine-free interval. Platelets from migraine patients differ significantly in their behaviour from normal platelets, and these differences can explain the onset and recurrence of attacks.
D000227:Adenine Nucleotides / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D001791:Blood Platelet Disorders / Q000150:complications*; D002395:Catecholamines / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000209:etiology*; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D012701:Serotonin / Q000097:blood
D000227:Adenine Nucleotides; D002395:Catecholamines; D012701:Serotonin