Association between Wilms tumor and gonadal dysgenesis.
The classification of intersexuality was determined in 10 patients with an intersex disorder who subsequently suffered a Wilms tumor. Of these 10 patients 7 (70 per cent) had a disorder of gonadal dysgenesis: 5 had mixed gonadal dysgenesis, 1 had dysgenetic male pseudohermaphroditism and 1 had 46XY pure gonadal dysgenesis. Because the gonads of patients with either of these 3 disorders have a high predilection for the development of testicular neoplasia, the concomitant occurrence of renal tumors in such a patient population suggests that a common defect in the urogenital ridge, the embryonic precursor of the kidneys and gonads, may be the cause of this association.
D002648:Child; D003456:Cryptorchidism / Q000150:complications; D012734:Disorders of Sex Development / Q000150:complications; D006059:Gonadal Dysgenesis / Q000150:complications*; D006801:Humans; D007021:Hypospadias / Q000150:complications; D007621:Karyotyping; D008297:Male; D009061:Mouth Mucosa / Q000166:cytology; D009095:Mullerian Ducts; D014770:Virilism / Q000150:complications; D009396:Wilms Tumor / Q000150:complications*