Effect of adrenergic agents on the secretion of gastrointestinal immunoreactive glucagon in depancreatized dogs.
To elucidate the mode of action of adrenergic agents on gastric A cells, the effects of infusion of adrenergic agonists and antagonists on the secretion of gastrointestinal immunoreactive glucagon (gastrointestinal IRG) from gastric A cells were investigated in 45 conscious, depancreatized dogs untreated with insulin. Large amounts (0.6 micrograms/kg/min) of epinephrine, norepinephrine, and isoproterenol stimulated the release of gastrointestinal IRG, and catecholamine-induced gastrointestinal IRG release was completely abolished by simultaneous infusion of the specific beta receptor-blocking compound, propranolol, but not by alpha receptor blockade with phentolamine. These findings suggest that, when adrenergic agonists are infused in large amounts, they may act through a beta receptor to increase the release of gastrointestinal IRG.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D005753:Gastric Mucosa / Q000378:metabolism; D005934:Glucagon / Q000276:immunology / Q000378:metabolism*; D007263:Infusions, Parenteral; D007328:Insulin / Q000378:metabolism; D010180:Pancreatectomy; D013268:Stimulation, Chemical; D013270:Stomach / Q000187:drug effects*; D013565:Sympatholytics / Q000494:pharmacology*; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D001786:Blood Glucose; D007328:Insulin; D013565:Sympatholytics; D005934:Glucagon