The possible role of magnesium in hypercalcemic hypertension.
Hypercalcemic conditions are commonly associated with hypertension and with abnormal magnesium homeostasis. The mechanism by which the hypertension of hypercalcemia is mediated is not clear, and the role that magnesium may play in its generation has not been examined. We review here the available clinical and experimental data and propose a role for abnormal magnesium metabolism in the mediation and generation of the hypertension of hypercalcemia.
D000818:Animals; D002118:Calcium / Q000097:blood*; D000242:Cyclic AMP / Q000378:metabolism; D015232:Dinoprostone; D004837:Epinephrine / Q000494:pharmacology; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008274:Magnesium / Q000502:physiology*; D008954:Models, Biological; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010281:Parathyroid Hormone / Q000494:pharmacology; D011458:Prostaglandins E / Q000652:urine; D012083:Renin / Q000097:blood; D014664:Vasodilation
D010281:Parathyroid Hormone; D011458:Prostaglandins E; D000242:Cyclic AMP; D012083:Renin; D008274:Magnesium; D015232:Dinoprostone; D002118:Calcium; D004837:Epinephrine