Inhibition of Ca-movement and mechanical movement in rabbit taenia coli by a smooth muscle relaxant (suloctidil).
A smooth muscle relaxant (suloctidil) relaxed a contractile response of taenia coli to acetylcholine and noncompetitively depressed a dose response curve of Cacl2 Ca-uptake by the microsomal fraction was inhibited by suloctidil. Its noncompetitive antiacetylcholine activity and inhibitory action on Ca-uptake were not influenced by an increase of external Ca-concentration. Ca-release from the Ca-incorporated microsomal fraction was not significantly influenced by suloctidil. These results suggest that suloctidil inhibit Ca-influx noncompetitively, thus inducing smooth muscle relaxation.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003106:Colon / Q000187:drug effects; D005711:Gallopamil / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000378:metabolism*; D010208:Papaverine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology*; D011817:Rabbits; D013468:Suloctidil / Q000494:pharmacology*
D010880:Piperidines; D011412:Propanolamines; D005711:Gallopamil; D011189:Potassium Chloride; D010208:Papaverine; D002118:Calcium; D013468:Suloctidil