Dynorphin: a possible modulatory peptide on morphine or beta-endorphin analgesia in mouse.
Dynorphin-(1-13), but not dynorphin-(1-9) has been shown to have significant effects on opiate and beta-endorphin-induced analgesia despite not having any appreciable analgesic activity itself. Dynorphin had no effect on Sandoz FK33824 compound-induced analgesia.
D000700:Analgesics; D000818:Animals; D004347:Drug Interactions; D004399:Dynorphins; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D001615:beta-Endorphin
D000700:Analgesics; D004723:Endorphins; D001615:beta-Endorphin; D004399:Dynorphins; D009020:Morphine