Novel codon utilization within the vaccinia virus thymidine kinase gene.
The nucleotide and predicted amino acid sequences of the thymidine kinase genes encoded by vaccinia virus and herpes simplex virus (type 1) were analyzed, and there was no evidence of any significant homology. The manner in which the triplet code was used by each virus was also examined. The frequencies of codon utilization by the herpes virus gene were very similar to those used by most human genes, whereas the vaccinia virus gene was quite distinct, suggesting novel evolutionary and regulatory mechanisms.
D003062:Codon; D012333:RNA, Messenger; D018139:Simplexvirus / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics*; D014616:Vaccinia virus / Q000235:genetics*; D014779:Virus Replication
D003062:Codon; D012333:RNA, Messenger; D013937:Thymidine Kinase