[Effect of psychotropic drugs on cerebral Ca-activated ATPase in vitro].
Neuroleptics, particularly haloperidol and perphenazine, inhibit the activity of brain Ca, Mg-ATPase to a greater extent than the antidepressants benactizin and amphetamine. The actomyosin-like Ca-ATPase is far less sensitive to the psychotropic drugs than Ca,Mg-AtPase. It is suggested that the inhibition of brain Ca,Mg-AtPase by neuroleptics may play a certain role in their antipsychotic action.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001535:Benactyzine / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology; D006168:Guinea Pigs; D006220:Haloperidol / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D010546:Perphenazine / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D014196:Trazodone / Q000494:pharmacology
D011619:Psychotropic Drugs; D001535:Benactyzine; D000661:Amphetamine; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D010546:Perphenazine; D006220:Haloperidol; D007099:Imipramine; D002746:Chlorpromazine; D014196:Trazodone
Vliianie psikhotropnykh sredstv na Ca-aktiviruemye ATF-azy mozga in vitro.