title: Failure of somatostatin to influence experimental tumor cell growth in vivo and in vitro.
abstract: The influence of somatostatin on tumor cell growth was studied in vivo in mice (sarcoma 180 ascites tumor and Lewis lung tumor) and in vitro on nontransformed and polyoma-transformed cell lines. 4 or 20 micrograms/100 g of cyclic somatostatin and 4 micrograms/100 g of linear protamin Zn-bound somatostatin were injected s.c. twice daily in the in vivo study. Cyclic somatostatin (1, 4 or 10 micrograms/ml) was added twice daily to the cell cultures. Somatostatin administration influenced neither the survival of animals nor the growth rate of cultured cell lines.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002472:Cell Transformation, Viral / Q000187:drug effects; D002478:Cells, Cultured; D008175:Lung Neoplasms / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000503:physiopathology; D011120:Polyomavirus; D051381:Rats; D012513:Sarcoma, Experimental / Q000503:physiopathology*; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D013004:Somatostatin