title: Leukotriene C5: a slow reacting substance derived from eicosapentaenoic acid.
abstract: Mouse mastocytoma cells incubated with ionophore A23187 and eicosapentaenoic acid (n-3) produced a slow reacting substance with different properties compared with leukotriene C4 (previously designated leukotriene C). This product was characterized by spectroscopy and enzymatic and chemical degradations to be 5-hydroxy-6-S-glutathionyl-7,9,11,14,17-eicosapentaenoic acid (leukotriene C5). Leukotriene C5 has similar biological activity on the isolated guinea pig ileum but is less potent than is leukotriene C4.
mesh_terms: D000818:Animals; D001681:Biological Assay; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D004537:Eicosanoic Acids / Q000096:biosynthesis* / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis / Q000378:metabolism*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007668:Kidney / Q000201:enzymology; D008084:Lipoxygenase / Q000378:metabolism; D012515:Mast-Cell Sarcoma / Q000378:metabolism; D051379:Mice; D010944:Plants / Q000201:enzymology; D013189:SRS-A / Q000031:analogs & derivatives*; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D004537:Eicosanoic Acids; D005231:Fatty Acids, Unsaturated; D013189:SRS-A; C026144:leukotriene C-5; D015118:Eicosapentaenoic Acid; D008084:Lipoxygenase; D005723:gamma-Glutamyltransferase