title: Captopril and frusemide in severe drug-resistant hypertension.
abstract: 10 patients with severe refractory hypertension were treated with captopril and frusemide. All patients had uncontrolled blood pressure (mean arterial pressure > 140 mm Hg), and 7 had developed accelerated hypertension despite maximum conventional treatment. Captopril and frusemide controlled blood pressure in all 10 patients, without side effects in 9. There was a significant rise in plasma-potassium in 9 patients (1 mmol/l), and hyperkalaemia (plasma-potassium > 6 mmol/l) developed in 3 patients despite coincident treatment with frusemide.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002216:Captopril / Q000008:administration & dosage* / Q000627:therapeutic use; D003971:Diastole / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D006974:Hypertension, Malignant / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*; D013599:Systole / Q000187:drug effects
chemical_list: D005665:Furosemide; D011392:Proline; D002216:Captopril