Acute kidney toxicity of sodium fluoride in the rat.
Single i.p injection of 0, 0.05, 0.10, 0.25, 0.50 and 1.00 mmol NaF/kg to male rats induced a dose-related increase of urine gamma-glutamyl transferase (GGT) elimination on the first day for all doses higher or equal to 0.25 mmol NaF/kg. Kidney damage began between 2--4 h following the injection and lasted only 12 h for the 0.50 mmol NaF/kg dose. There was an increase of diuresis and of phosphaturia even at lower doses.
D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010710:Phosphates / Q000652:urine; D051381:Rats; D012969:Sodium Fluoride / Q000494:pharmacology / Q000633:toxicity*; D005723:gamma-Glutamyltransferase / Q000652:urine
D010710:Phosphates; D012969:Sodium Fluoride; D005723:gamma-Glutamyltransferase; D005459:Fluorides