title: The psychophysiologic aspects of stress in juvenile diabetes mellitus.
abstract: Diabetes Mellitus is the most common endocrine disease found in children, and its reported incidence is increasing. Most investigators now agree that improved diabetic control is effective in decreasing both long and short term complications. The delineation of factors which affect control are, therefore, of importance. Classically, the physician has emphasized insulin dose, presence of infection, diet, and exercise. Emotional factors have long been thought to play a role in diabetes mellitus. The exact nature of this role, however, has been rather elusive and controversial. The authors review this literature, summarize the major viewpoints, and conclude that physiological factors can influence the physiology of the disease. The focus of this paper is the synthesis of recent advances in basic metabolic, endocrinologic, and stress research, relevant to juvenile diabetes, into a psychophysiologic model. The authors discuss future research directions necessary for clarification of the model, as well as its psychological and physiological therapeutic implications.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D001676:Biofeedback, Psychology; D002395:Catecholamines / Q000378:metabolism; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000523:psychology / Q000628:therapy; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D008960:Models, Psychological; D011433:Propranolol / Q000627:therapeutic use; D013004:Somatostatin / Q000494:pharmacology; D013315:Stress, Psychological / Q000150:complications*
chemical_list: D002395:Catecholamines; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D005934:Glucagon; D011433:Propranolol