title: Synaptic proteins after electroconvulsive seizures in immature rats.
abstract: The forebrain content of several rat brain synaptic proteins (synaptin, D1, D2, and D3) was reduced in rats receiving electroconvulsive seizures on days 2-11, 9-18, or 19-28 and sacrificed at the age of 30 days. Forebrain weight, total protein, and the glial enzyme glutamine synthetase were also decreased, whereas the neuronal enolase 14-3-2 was unchanged. The findings suggest that seizures in the immature rat brain resulted in a parallel reduction of synaptic material and of the amount of glial cells. The increased concentration of the enolase 14-3-2 found in rats seizured on days 19-28 may reflect the high demands on the glycolytic system during the seizures.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004597:Electroshock; D005260:Female; D005974:Glutamate-Ammonia Ligase; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009929:Organ Size; D051381:Rats
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C023513:brain-specific protein D2, rat; C028116:nervous system specific protein D1; C028117:nervous tissue specific protein D3; C030625:synaptin; D005974:Glutamate-Ammonia Ligase