Haloperidol and clonidine increase, and apomorphine decreases ultrasonic vocalizations by gerbils.
Ten psychotropic drugs that have putative effects on central brain neurotransmitters were assessed for influences on ultrasonic signaling relative to general activity in male Mongolian gerbils. Haloperidol (1 mg/kg IP), a dopamine antagonist, and clonidine (0.1 mg/kg IP), a norepinephrine agonist, increased ultrasonic signaling, and apomorphine (5 mg/kg IP), a dopamine agonist, decreased ultrasonic signaling. Catecholamines may modulate ultrasonic signaling in the gerbil. Body temperature changes were positively with ultrasonic emission in tests after saline, haloperidol, apomorphine, and 5-hydroxytryptophan (30 mg/kg IP).
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D005849:Gerbillinae / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology; D014465:Ultrasonics; D014828:Vocalization, Animal / Q000187:drug effects*
D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs; D006916:5-Hydroxytryptophan; D006220:Haloperidol; D003000:Clonidine; D001058:Apomorphine