title: Solubility in amide-water cosolvent systems: a thermodynamic view.
abstract: The solubility of methyl p-hydroxybenzoate was determined in a series of amide-water cosolvents in the temperature range 25-40 degrees C. Thermodynamic values for the transfer of the ester between the cosolvent system were calculated using a method which permits a focus on the effects of amide alkylation. The results are interpreted in terms of hydrophobic bonding principles which suggest that the alkyl groups on the amide detract from amide-water interaction and enhance amide-ester interaction.
mesh_terms: D000577:Amides; D062385:Hydroxybenzoates; D012995:Solubility; D012997:Solvents; D013816:Thermodynamics; D014867:Water
chemical_list: D000577:Amides; D062385:Hydroxybenzoates; D012997:Solvents; D014867:Water