The effect of ion composition on cellular membrane potentials during selective coronary arteriography.
An animal experimental study on seven thoracotomized dogs was designed to investigate the effects of intracoronarily injected sodium meglumine diatrizoate on myocardial electrophysiology and to evaluate the contribution of the corresponding changes of electrolyte levels in coronary blood. For this purpose the effects of alterations in the Na+-, K+- and Ca++-concentrations in coronary blood were studied separately by intracoronarily injected model solutions. Membrane potentials were recorded from the left ventricular myocardium by a modified microelectrode technique which is applicable to the beating and blood perfused heart in situ. Following selective coronary arteriography there was a temporary hyperpolarization of resting potentials and a prolongation of action potentials which may be explained by a contrast-induced local deficiency of potassium and calcium ions and by a relative prevalence of sodium ions in coronary blood. In selective coronary arteriography the synchronicity of cardiac excitation is disturbed by the regional prolongation of action potentials, which may induce ventricular arrhythmias.
D000200:Action Potentials / Q000187:drug effects; D000792:Angiography / Q000379:methods; D000818:Animals; D002118:Calcium / Q000097:blood; D017023:Coronary Angiography; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D008839:Microelectrodes; D009206:Myocardium / Q000378:metabolism; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood
D007473:Ion Channels; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D012964:Sodium; D011188:Potassium; D002118:Calcium