Inhibition of Plasmodium berghei sporozoite invasion of cultured hepatoma cells.
Monoclonal antibody to a Plasmodium berghei surface antigen blocked sporozoite invasion of cultured human hepatoma cells. Such antibodies were of IgG1 class. Two monoclonals of the IgM class, probably reactive with the same antigen, did not neutralize invasion. It appears that the sporozoite surface antigen mediates invasion of hepatoma cells.
D000911:Antibodies, Monoclonal / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000469:parasitology* / Q000473:pathology; D002478:Cells, Cultured; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008099:Liver / Q000276:immunology / Q000469:parasitology; D008113:Liver Neoplasms; D010962:Plasmodium berghei / Q000276:immunology / Q000502:physiology*
D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D007074:Immunoglobulin G