Reduction of menstrual blood loss by naproxen in intrauterine contraceptive device users.
Eleven patients with objective evidence of menorrhagia (greater than 80 ml menstrual blood loss for two cycles) while fitted with an IUD were treated during three consecutive menstruations with the prostaglandin synthetase inhibitor naproxen. Menstrual blood loss was significantly reduced (p less than 0.001) from a pretreatment value of 131 +/- 12 ml to 88 +/- 9 ml on naproxen therapy. In the cycle following naproxen therapy, menstrual blood loss returned to the pretreatment level of 129 +/- 10 ml. Continued IUD usage was made more acceptable by naproxen therapy.
D001769:Blood; D005260:Female; D006801:Humans; D007434:Intrauterine Devices; D008595:Menorrhagia / Q000188:drug therapy; D008598:Menstruation / Q000187:drug effects*; D009288:Naproxen / Q000494:pharmacology* / Q000627:therapeutic use
D009288:Naproxen