6-Keto-prostaglandin E1 and prostaglandin E2 stimulate aldosterone production in bovine adrenal glands.
In order to investigate the effect of prostaglandins on aldosterone synthesis, dispersed bovine adrenal cells were incubated with prostaglandins and the aldosterone concentration was measured by radioimmunoassay. The result was that aldosterone production was stimulated by 6-keto-prostaglandin E1 and prostaglandin E2.
D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000096:biosynthesis*; D000527:Alprostadil / Q000031:analogs & derivatives*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D015232:Dinoprostone; D011464:Epoprostenol / Q000494:pharmacology; D066298:In Vitro Techniques; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E; D000804:Angiotensin II; D000450:Aldosterone; C022950:6-ketoprostaglandin E1; D000324:Adrenocorticotropic Hormone; D011464:Epoprostenol; D000527:Alprostadil; D015232:Dinoprostone