Deficit of suppressor T cells in active multiple sclerosis.
Suppressor T cells in forty-seven patients with multiple sclerosis (MS) were studied by indirect immunofluorescence by means of monoclonal antibodies directed at T-cell subsets. Suppressor cell numbers were depressed in patients with acute exacerbation of MS and in patients with continuous progressive deterioration. In one case the T-cell anomaly was observed one week before the onset of the acute phase; it had been absent 4 months before exacerbation.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis / Q000134:cerebrospinal fluid; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000914:Antibodies, Viral