title: [On the synthesis of compounds with beta-adrenergic activity (author's transl)].
abstract: It is reported of the synthesis of 1-phenoxy-2-hydroxy-3-aminopropane derivatives with different substituents in the phenoxy residue as well as in the amino group. The potency and the efficacy of these derivatives depend on the substituents. By the introduction of the arylamino-ethyl residue into the nitrogen atom, beta-adrenergic locking agents with marked agonistic activity are obtained.
mesh_terms: D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis*; D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis*; D000818:Animals; D006321:Heart / Q000187:drug effects; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011412:Propanolamines
vernacular_title: Zur Synthese von beta-adrenerg wirksamen Verbindungen.