title: Neuroleptic-free intervals in the treatment of schizophrenia.
abstract: During a period of 1-2 1/2 years the neuroleptic regimen of 14 schizophrenic outpatients was interrupted every 6 months by drug holidays of 6 weeks' duration. As a result, 10 patients achieved a substantially reduced maintenance dose. The authors were unable to predict for whom the drug holidays would be safe.
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis
chemical_list: D014150:Antipsychotic Agents