Effects of corticotropin-releasing factor (CRF) on aldosterone and 18-hydroxycorticosterone secretion.
To determine the effect of CRF administration on in vivo mineralocorticoid release, we performed experiments in rats and in man. In man, plasma aldosterone and 18-hydroxycorticosterone levels increased following i.v. CRF injection. In sitting subjects, the response was greater than in supine subjects, indicating an influence of posture. In the rat, CRF-induced increases in corticosteroid levels were dose-related, the largest response being for corticosterone, followed by 18-hydroxycorticosterone and then by aldosterone. Thus synthetic ovine CRF stimulates not only glucocorticoid but also mineralocorticoid secretion from the adrenals.
D015069:18-Hydroxycorticosterone / Q000097:blood / Q000378:metabolism*; D000302:Adrenal Cortex / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone