In vivo-in vitro correlations with a commercial dissolution simulator. I: Methenamine, nitrofurantoin, and chlorothiazide.
Dissolution profiles were determined for nine methenamine, 14 nitrofurantoin, and six chlorothiazide dosage forms using a dissolution simulator. Various in vivo-in vitro correlations were examined. The best correlation for methenamine was between the maximum urinary excretion rate and the time for 15% dissolution. A good correlation for the 50-mg nitrofurantoin tablets was also found between cumulative percent of drug excreted in 12 hr and the percent dissolved in 1 hr. There were no significant correlations for the 100-mg nitrofurantoin dosage forms. Good correlations were also observed for the 250- and 500-mg chlorothiazide tablets between the percent of drug dissolved in 1 min or the time for 15% dissolution and the maximum excretion rate.
D000042:Absorption; D002740:Chlorothiazide / Q000737:chemistry / Q000493:pharmacokinetics*; D008709:Methenamine / Q000737:chemistry / Q000493:pharmacokinetics*; D009582:Nitrofurantoin / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility; D013607:Tablets
D013607:Tablets; D002740:Chlorothiazide; D009582:Nitrofurantoin; D008709:Methenamine