Damages of the mitochondrial membrane in Adriamycin treated mice.
OF1 Swiss male and female mice received adriamycin (ADM) i.p. in increasing doses. Animals were killed after 2 or 4 days. Hearts were removed and mitochondria were isolated. ADM induced an inactivation of the respiratory enzymes closely related to an increase of the mitochondrial membrane viscosity and of the lipid peroxidation. Two ADM derivatives studied similarly did not produce these effects.
D000818:Animals; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D007425:Intracellular Membranes / Q000187:drug effects* / Q000201:enzymology; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D051379:Mice; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000201:enzymology; D009245:NADH Dehydrogenase / Q000037:antagonists & inhibitors
D008054:Lipid Peroxides; C044236:N-acetyldoxorubicn; D004317:Doxorubicin; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; C018979:5-iminodaunorubicin; D003630:Daunorubicin