Disposition of all-trans-retinoic acid in mice following oral doses.
The concentrations of all-trans-retinoic acid in serum and tissues from mice were measured following oral dosing with 10 mg/kg. Serum levels of the drug reached a maximum within 45 min, then declined after 2 hr in a linear fashion. Tissue levels reached a maximum within 30 to 120 min, then declined after 3 hr in an exponential fashion with t 1/2 values of 25 to 68 min. The longest t 1/2 value was observed in brain. Only small amounts of unchanged all-trans-retinoic acid were observed in bile and feces and none was found in urine. Polar material, however, was present in bile, feces, and urine.
D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D014018:Tissue Distribution; D014212:Tretinoin / Q000008:administration & dosage / Q000378:metabolism*
D014212:Tretinoin