[Inhibition of superoxide-dependent processes by aminoglycoside antibiotics].
The ability of various antibiotics to inhibit superoxide anion(O-2)-mediated formation of adrenochrome from adrenaline and recovery of cytochrome c by xanthine oxidase was studied. In the adrenaline system (pH 10.2), aminoglycosides might be arranged, according to the inhibitory effect, in the following order: monomycin greater than gentamicin greater than kanamycin greater than lincomycin greater than streptomycin. In the xanthine oxidase system (pH 7.8), that order was the following: monomycin greater than gentamicin greater than lincomycin greater than greater than kanamycin. It was suggested that the antibiotic inhibition of the O-2-dependent processes at the essential sites of metabolism and/or the antibiotic involvement into the process of free radical oxidation initiated by O-2 in the cells might be one of the mechanisms of the drug action and toxicity with respect to the host.
D000323:Adrenochrome / Q000378:metabolism; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003574:Cytochrome c Group / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005609:Free Radicals; D066298:In Vitro Techniques; D007700:Kinetics; D010084:Oxidation-Reduction / Q000187:drug effects; D012996:Solutions; D013481:Superoxides / Q000037:antagonists & inhibitors*; D014969:Xanthine Oxidase / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003574:Cytochrome c Group; D005609:Free Radicals; D012996:Solutions; D013481:Superoxides; D000323:Adrenochrome; D014969:Xanthine Oxidase; D004837:Epinephrine
Ingibirovanie O2(-)-zavisimykh protsessov aminoglikozidnymi antibiotikami.