title: Interactions between the neuromuscular blocking drug Org NC 45 and some anaesthetic, analgesic and antimicrobial agents.
abstract: The effects of some anaesthetics and other agents used in anaesthetic practice on the neuromuscular blocking activity of cumulative doses of Org NC 45 have been studied in cats anaesthetized with chloralose. As expected from studies with other neuromuscular blocking drugs, both inhalation and i.v. anaesthetics reduced the doses of Org NC 45 required for neuromuscular blockade. An apparently specific potentiating interaction between Org NC 45 and metronidazole was observed.
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D014673:Vecuronium Bromide
chemical_list: D000700:Analgesics; D000777:Anesthetics; D009466:Neuromuscular Blocking Agents; D008795:Metronidazole; D014673:Vecuronium Bromide; D010197:Pancuronium; D003975:Diazepam