[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
The combined use of di-n-propylacetate with phenazepam, diazepam, phenobarbital or phenytoin was shown to be followed by reciprocal potentiation of the anticonvulsant activity of the drugs in a variety of experimental epileptic seizures in mice according to the tests of shock and antagonism with corasole and thiosemicarbazide. The potentiating effect of the subthreshold dose of di-n-propylacetate on anticonvulsant effects of benzodiazepines, phenobarbital and phenytoin was more pronounced than the effect of the drugs administered in the subthreshold doses on the anticonvulsant activity of di-n-propylacetate. Of both combinations, di-n-propylacetate plus benzodiazepines proved to be most efficacious one. The unidirectional effect of the combined drugs on the different stages of the development of GABA-ergic system inhibitory function in the CNS activity is assumed to be of importance in the mechanism of reciprocal potentiation.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D000927:Anticonvulsants; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage; D003975:Diazepam / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010634:Phenobarbital / Q000008:administration & dosage*; D010672:Phenytoin / Q000008:administration & dosage*; D012640:Seizures / Q000188:drug therapy; D012663:Semicarbazides / Q000037:antagonists & inhibitors; D014635:Valproic Acid / Q000008:administration & dosage*
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D012663:Semicarbazides; D001569:Benzodiazepines; C017928:phenazepam; C005151:thiosemicarbazide; D014635:Valproic Acid; D010672:Phenytoin; D003975:Diazepam; D010433:Pentylenetetrazole; D010634:Phenobarbital
Protivosudorozhnoe deĭstvie di-N-propilatsetata v sochetanii s benzodiazepinami, fenobarbitalom i fenitoinom.