[Effect of exercise on plasma cyclic AMP].
The purpose of this study was to confirm the relationship between cyclic AMP(cAMP) level in plasma and changes of hormones concentrations in blood, during and after physical exercise. The results were as follows: At rest, plasma cAMP were 23.1 p mole/ml on the average and decreased after glucose loading. The level in plasma increased in proportion to the intensity of exercises. Under the 50% condition of the maximal intensity, cAMP level in plasma was about 40 p mole/ml and the contents of both thyroxine and growth hormone in serum clearly increased. And, under the 70% of the maximal, the contents of both adrenaline and noradrenaline in serum as well as that of cAMP in plasma increased. Plasma cAMP level also increased by prolongation of exercise (ca 45 p mole/ml). And when exercise lasted over 1.5 hrs, plasma glucagon level began to rise. The effect of carbohydrate load to lower the levels of plasma cAMP were also found during physical exercise. These results suggested that the cAMP level in plasma was affected, not only by the some regulating factors of glycolytic activities such as adrenaline and glucagon, but also by the production of thyroxine and growth hormone at the onset of exercise.
D000328:Adult; D001510:Bed Rest; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005502:Food; D005951:Glucose Tolerance Test; D006801:Humans; D006815:Hunger; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D012016:Reference Values
D000242:Cyclic AMP