Thalidomide-induced peripheral neuropathy. Effect of serum factor on nerve cultures.
Sensory neuropathies developed in three of four patients with prurigo nodularis who had been treated with thalidomide. The serum samples of the patients who had neuropathy produced morphologic changes in cultured dorsal root ganglion cells. These observed changes support the postulate that thalidomide induces primary neuronal degeneration.
D000328:Adult; D000368:Aged; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005333:Fetus; D005727:Ganglia, Spinal / Q000166:cytology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D011536:Prurigo / Q000188:drug therapy; D051381:Rats; D012677:Sensation; D013792:Thalidomide / Q000009:adverse effects* / Q000627:therapeutic use
D013792:Thalidomide