Studies on the polyoma-virus-induced tumor-specific transplantation antigen (TSTA)--does middle or large T-antigen play a role?
Mice and rats could be immunized against the polyoma-virus-induced tumor-specific transplantation antigen (TSTA) by repeated inoculation of frozen or irradiated cells of an MT-cDNA-transformed rat cell line (2.8) that contains only the polyoma middle T-antigen, or by cells that carried a host range mutant and expressed a full-length large T-antigen, but only non-functional N-terminal fragments of small and middle T. This shows that neither large T nor an intact middle T is necessary to elicit a polyoma tumor-specific graft rejection response. Either one of them is sufficient by itself.
D000818:Animals; D000952:Antigens, Polyomavirus Transforming; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism; D051379:Mice; D009154:Mutation; D009368:Neoplasm Transplantation; D011120:Polyomavirus / Q000235:genetics* / Q000276:immunology; D011494:Protein Kinases / Q000235:genetics*; D051381:Rats; D014183:Transplantation, Heterologous; D014764:Viral Proteins / Q000235:genetics*
D000952:Antigens, Polyomavirus Transforming; D014764:Viral Proteins; D004247:DNA; D011494:Protein Kinases