Age-related changes in the kinetic properties of the acetyl-CoA carboxylase and phospholipid content of rat liver.
Age-related changes in the activity of rat liver acetyl-CoA carboxylase and the phospholipid content have been investigated in detail between birth and the age of 2.5 years. During postnatal development and ageing the enzyme shows varying kinetic properties as well as different specific activities. During the first days of postnatal life the activity declines. A minimum of 20% from adult levels is found 4 days after birth. Thereafter the specific activity rapidly increases. The highest specific activities are found in old animals. Major changes can be found in the kinetics of the activation of the enzyme by citrate. The influence of ATP concentration shows minor age-related alterations. The phospholipid composition of the rat liver is age-dependent, too. The coincidence of modifications in the phospholipid composition and correlated variations of the acetyl-CoA carboxylase activity as well as developmental increase of the endoplasmic reticulum in the liver and the growth rate of the rat brain are discussed.
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002951:Citrates / Q000494:pharmacology; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D002951:Citrates; D010743:Phospholipids; D008025:Ligases; D000103:Acetyl-CoA Carboxylase