[Effect of stimulants on the tranquilizing, hypnotic and myorelaxant action of phenazepam].
It has been established in experiments on mice and rats that sydnocarb, strychnine, corasol and thiosemicarbazide are correctors as regards the myorelaxant effect of phenazepam. The correcting effect of the drugs manifests to a greater degree under conditions of eliminating the side effects that developed. Electroencephalographic studies on the combined action of phenazepam and sydnocarb on the sleep cycles in rats have shown sydnocarb to reduce the hypnotic effect of the tranquilizer. Under conflict situation sydnocarb or strychnine exert no effect on the tranquilizing action of phenazepam. Conversely, corasol and thiosemicarbazide diminish the anxiolytic effect of the tranquilizer. The data obtained allowed one to recommend that sydnocarb and strychnine be introduced in medical practice as correctors of the side effects produced by phenazepam.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage*; D004347:Drug Interactions; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008297:Male; D051379:Mice; D009125:Muscle Relaxants, Central / Q000008:administration & dosage; D010069:Oxadiazoles / Q000008:administration & dosage*; D010433:Pentylenetetrazole / Q000008:administration & dosage*; D051381:Rats; D012663:Semicarbazides / Q000008:administration & dosage*; D013331:Strychnine / Q000008:administration & dosage*; D013558:Sydnones / Q000008:administration & dosage*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; D010069:Oxadiazoles; D012663:Semicarbazides; D013558:Sydnones; D001569:Benzodiazepines; C017928:phenazepam; C005151:thiosemicarbazide; D013331:Strychnine; C009257:sidnocarb; D010433:Pentylenetetrazole
Vliianie stimuliatorov na trankviliziruiushchee, snotvornoe i miorelaksantnoe deĭstvie fenazepama.