Uniformity of content requirements for tablets and capsules.
Present pharmacopoeial requirements for uniformity of content of tablets and capsules are based on tests by attributes. A test for uniformity of content based on the root mean square deviation about target (ST) is more reliable than the pharmacopoeial tests and has the added convenience of using a single statistic to control both the mean content and the variation about the mean. Implications of the use of the statistic ST in uniformity requirements are discussed.
D002214:Capsules / Q000592:standards*; D004739:England; D010602:Pharmacopoeias as Topic; D013223:Statistics as Topic; D013607:Tablets / Q000592:standards*; D014481:United States
D002214:Capsules; D013607:Tablets