title: Effect of oral monosodium glutamate on glutamic acid levels in the nucleus arcuatus of the hypothalamus and on serum osmolality of adult and infant mice.
abstract: Monosodium glutamate (MSG) given by gavage to 7-day-old mice at 2 g/kg body weight (b.wt.) as a 20% solution w/v resulted in a 27% increase in the glutamic acid (GA) content in the nucleus arcuatus of the hypothalamus (NAH). When MSG was administered by gavage to adult mice at 4 g/kg b.wt. as a 20% solution w/v, GA levels in NAH remained unchanged. Serum osmolality, measured after oral MSG, was elevated in infant mice but was unaffected in adults.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001769:Blood / Q000187:drug effects*; D005971:Glutamates / Q000009:adverse effects* / Q000097:blood; D018698:Glutamic Acid; D007031:Hypothalamus / Q000032:analysis* / Q000187:drug effects; D008297:Male; D051379:Mice; D009994:Osmolar Concentration; D012970:Sodium Glutamate / Q000009:adverse effects*
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D012970:Sodium Glutamate