title: Interaction of histamine H2-receptor blocking drugs with the noradrenergic system in rat brain and heart.
abstract: The i.v.t. injection of burimamide (BUR), 50 micrograms, or cimetidine (CIM), 250 micrograms, decreased significantly the hypothalamic noradrenaline (NA) content by 32 and 21%, and significantly increased the whole brain 3-methoxy-4-hydroxyphenylglycol level by 46 and 28%, respectively. The i.p. administration of BUR or metiamide (MET), at a dose of 50 mg/kg, caused a decrease in the rat heart NA content by 34 and 21%, respectively; CIM had no effect at doses up to 100 mg/kg i.p., whether given acutely or chronically.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D002049:Burimamide / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D008785:Metiamide / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats
chemical_list: D006635:Histamine H2 Antagonists; D008785:Metiamide; D002927:Cimetidine; D002049:Burimamide; D009638:Norepinephrine