Antiarrhythmic activity of cetiedil and its analogues.
Cetiedil), originally a molecule used for treatment of some vascular diseases, exhibits several pharmacological effects. The authors studied cetiedil's stabilizing effect on the membrane and the antagonism against calcium of Cetiedil and its analogues (amino 3-thienylacetic esters). After completion of numerous pharmacological tests giving evidence of antidysrhythmic effects of the molecule and more especially in the digitalic arrhythmias and ventricular fibrillation induced by calcium (where it is more active than other products tested), the authors conclude that Cetiedil might enter in group I of Vaughan and William's classification of antiarrhythmic drugs. It is like Verapamil an inhibitor of the calcium penetration. This especially interesting antidysrhythmic profile suggests clinica research to determine the special position of Cetiedil in the treatment of heart rhythm troubles.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000328:Adult; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001381:Azepines / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D002118:Calcium / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002725:Chloroform; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010042:Ouabain / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013876:Thiophenes / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D014693:Ventricular Fibrillation / Q000188:drug therapy
D000317:Adrenergic alpha-Antagonists; D000889:Anti-Arrhythmia Agents; D001381:Azepines; D013876:Thiophenes; D010042:Ouabain; C006955:cetiedil; D002725:Chloroform; D011802:Quinidine; D002118:Calcium