Attenuation of ethanol-induced conditioned taste aversion by naloxazone: behavioral evidence for an opiate receptor-mediated morphine-ethanol interaction.
When rats are presented with a novel saccharin solution and immediately injected with either morphine or ethanol, they subsequently develop a conditioned taste aversion (CTA) to the saccharin solution which reflects the aversive component of the conditioning drug. The present study provides evidence which suggests that both morphine-induced and ethanol-induced CTAs can be blocked by the specific high-affinity binding opiate antagonist, naloxazone.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D012439:Saccharin; D013649:Taste / Q000502:physiology*
D011957:Receptors, Opioid; D009270:Naloxone; D000431:Ethanol; C024224:naloxazone; D009020:Morphine; D012439:Saccharin