The dual effect of L-proline on spreading depression in the chicken retina.
Evidence was presented for a glutamate agonistic effect of L-proline which promotes K+-based spreading depressions (SD) in chick retinas at relatively high concentrations (5 mM), in addition to an antagonistic effect which inhibits glutamate-based SDs at lower (2 mM) concentrations. Together these effects explain the observed biphasic effect of L-proline on the incidence of SD in the retina.
D000818:Animals; D002645:Chickens; D013181:Cortical Spreading Depression / Q000187:drug effects*; D004336:Drug Antagonism; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D011188:Potassium / Q000494:pharmacology; D011392:Proline / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects / Q000502:physiology*
D005971:Glutamates; D018698:Glutamic Acid; D011392:Proline; D011188:Potassium