Evidence that regulation of hepatic guanylate cyclase activity involves interactions between catalytic site -SH groups and both substrate and activator.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002384:Catalysis; D002850:Chromatography, Gel; D004789:Enzyme Activation / Q000187:drug effects; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009603:Nitroso Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013379:Substrate Specificity; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D009603:Nitroso Compounds; D013438:Sulfhydryl Compounds; D006162:Guanylate Cyclase