title: Gonadal findings in cryptorchid boys with Noonan's phenotype.
abstract: 7 patients with Noonan's syndrome, aged 5-16 years, complicated by bilateral cryptorchidism were examined by LH-RH and HCG stimulation tests, long-term HCG stimulation and testicular biopsy. 2 patients showed a good response and there was no effects in the remainder. Histological examination of the tests confirmed interstitial fibrosis in every case and showed abnormalities of the seminiferous tubules in 4 patients while in 1 patient the seminiferous tubules were composed of spermatocytes and spermatids. These hormonal and histological findings show different patterns of disturbance of the pituitary-gonadal system in male patients with Noonan's syndrome.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D003456:Cryptorchidism / Q000150:complications*; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000097:blood; D006801:Humans; D008297:Male; D009634:Noonan Syndrome / Q000097:blood / Q000150:complications*; D012671:Seminiferous Tubules / Q000473:pathology
chemical_list: D006063:Chorionic Gonadotropin; D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone