The treatment of "cimetidine resistant" peptic ulcers by ranitidine hydrochloride: a new histamine H2-receptor antagonist.
Twelve patients with endoscopically confirmed peptic ulcers which had failed to heal despite standard cimetidine therapy were treated with 300 mg ranitidine hydrochloride daily for 4 to 8 weeks. Nine patients had complete symptomatic relief although the ulcer was found to have healed endoscopically in only six. Two patients derived no benefit from treatment and in 1 patient symptoms continued despite ulcer healing. Ranitidine would appear, therefore, to be of benefit in some "cimetidine resistant" patients.
D002927:Cimetidine / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D005773:Gastroscopy; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000175:diagnosis / Q000188:drug therapy*; D011899:Ranitidine
D005663:Furans; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine