Cefmenoxime in surgical infections: treatment and penetration into peritoneal fluid and wound secretions.
Sixty patients (23 men and 37 women) with a median age of 56.7 years (range 20 to 80) and a median weight of 69 kg were treated with cefmenoxime as short-term perioperative prophylaxis. Patients were undergoing surgery for an infected gallbladder, bile duct, or colon or were being treated for local or diffuse peritonitis and soft tissue infections. Overall clinical efficacy including very good and good results could be achieved in 88.3 percent. Moderate clinical efficacy was achieved in six cases, two of which were due to Pseudomonas aeruginosa. In 38 of 60 patients an antibiogram could be performed before and after therapy. Of the isolated 46 strains, 40 pathogens (86.95 percent) were eradicated during cefmenoxime treatment and in two cases a replacement was observed. After one hour, peak concentrations in serum could be reached with over 70 micrograms/ml.
D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D015281:Cefmenoxime; D002439:Cefotaxime / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology
D015281:Cefmenoxime; D002439:Cefotaxime