Oncogenes: growth regulation and the papovaviruses polyoma and SV40.
Cellular oncogenes and their activated and retrovirus-coded counterparts play an important role in cellular regulation. Here the relationship between such oncogenes and the genes coding for the transforming proteins of the papovaviruses, polyoma viruses, and simian virus 40 (SV40) is discussed. It is concluded that polyoma virus may transform established cells by a mechanism involving activation of a cellular oncogene product, whereas SV40 may transform by a mechanism involving a previously little studied cytoplasmic form of the transforming protein.
D000818:Animals; D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000235:genetics / Q000502:physiology; D001483:Base Sequence; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004247:DNA / Q000378:metabolism; D004279:DNA, Viral; D004268:DNA-Binding Proteins / Q000235:genetics; D004815:Epidermal Growth Factor / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D009857:Oncogenes; D027383:Papillomaviridae / Q000235:genetics*; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D027382:Polyomaviridae; D011120:Polyomavirus / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics; D011505:Protein-Tyrosine Kinases; D013539:Simian virus 40 / Q000235:genetics*; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology
D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D010982:Platelet-Derived Growth Factor; D014764:Viral Proteins; D004815:Epidermal Growth Factor; D004247:DNA; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases