The effect of intracarotid perfusion of cerebrospinal fluid from patients with subarachnoid hemorrhage on cerebrovascular reactivity in rats.
Cerebrovascular resistance was measured in 10 rats with increasing dosages of 5-Hydroxytryptamine (5-HT). The internal carotid artery was perfused at constant flow with cerebrospinal fluid (CSF) from patients with ruptured intracranial aneurysms, and dose-response curves to 10 mu 1 boluses of 5-HT were compared with similar dose-response curves obtained during perfusion with Krebs' solution and with normal CSF (CSF-N). CSF from patients with subarachnoid hemorrhage (CSF-SAH) produced increased sensitivity to 5-HT.
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid*; D014655:Vascular Resistance / Q000187:drug effects
D012701:Serotonin