title: Prostacyclin increases cyclic-nucleotide responsiveness of lymphocytes from patients with systemic sclerosis.
abstract: Low cyclic-AMP levels within lymphocytes from five patients with systemic sclerosis showed a striking increase in response to isoprenaline after intravenous infusion of prostacyclin.
mesh_terms: D000249:Adenosine Monophosphate / Q000097:blood*; D000328:Adult; D000368:Aged; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D011453:Prostaglandins / Q000494:pharmacology*; D011928:Raynaud Disease / Q000097:blood
chemical_list: D011453:Prostaglandins; D000249:Adenosine Monophosphate; D011464:Epoprostenol; D007545:Isoproterenol