Effect of two types of beta-adrenergic blockade on gastric acid secretion during basal conditions and during histamine stimulation on non-vagotomized and in vagotomized gastric fistula dogs.
The effect of beta-adrenoreceptor blockade by propranolol and practolol on basal secretion and on submaximally histamine-stimulated gastric acid secretion was studied in conscious non-vagotomized and in vagotomized gastric fistula dogs. Neither propranolol (0.5 mg/kg) nor practolol (1.0 mg/kg), both intravenously, had a significant influence on basal or histamine-stimulated gastric acid secretion in non-vagotomized and vagotomized dogs. It is concluded that beta-adrenergic blockade has no influence on basal or histamine-stimulated gastric acid secretion in dogs. Furthermore, no differences were found between the non-vagotomized and the vagotomized stomach.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005747:Gastric Fistula / Q000503:physiopathology; D006632:Histamine / Q000494:pharmacology; D008297:Male; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011674:Pulse / Q000187:drug effects; D012636:Secretory Rate / Q000187:drug effects; D014628:Vagotomy
D000319:Adrenergic beta-Antagonists; D006632:Histamine; D011433:Propranolol; D011217:Practolol