Urine i-TXB2 in renal allograft rejection.
Immunoreactive thromboxane B2 (i-TXB2) was measured in daily urine samples from twelve patients after renal transplantation. In 21 of 30 rejection episodes, the increase in i-TXB2 preceded both the increase in serum beta 2-microglobulin (beta 2-MG) and the clinical diagnosis of rejection. In 26 of 30 rejection episodes, the increase in urine i-TXB2 preceded the increase in serum creatinine. The degree of change in i-TXB2 is greater than that of either serum beta 2-MG or creatinine. Urinary i-TXB2 was very high in one patient with deep venous thrombosis, but it did not rise in patients with urinary tract infection, pneumonia, or acute tubular necrosis. Thus, urinary i-TXB2 seems to be an early indicator of clinical renal allograft rejection.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000652:urine*; D013931:Thromboxanes / Q000652:urine*; D014184:Transplantation, Homologous; D001613:beta 2-Microglobulin / Q000032:analysis
D013931:Thromboxanes; D001613:beta 2-Microglobulin; D013929:Thromboxane B2; D003404:Creatinine