Interaction of the antitumor drug, L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) with renal brush border membranes. Specific labeling of gamma-glutamyl transpeptidase.
D000818:Animals; D000970:Antineoplastic Agents; D055598:Chemical Phenomena; D002621:Chemistry; D005998:Glycine / Q000031:analogs & derivatives*; D007555:Isoxazoles; D007668:Kidney / Q000201:enzymology*; D008297:Male; D008871:Microvilli / Q000201:enzymology; D008970:Molecular Weight; D010080:Oxazoles; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000302:isolation & purification / Q000378:metabolism*
D000970:Antineoplastic Agents; D007555:Isoxazoles; D010080:Oxazoles; D005723:gamma-Glutamyltransferase; C006303:acivicin; D005998:Glycine