A comparative ultrastructural study of virions in human pre-AIDS and simian AIDS.
Virions resembling the AIDS-associated retroviruses HTLV-III and LAV were identified between pseudopods of dendritic reticulum cells in lymph nodes from 3 patients with prodromal AIDS. The virions are morphologically distinguishable from HTLV-I and HTLV-II and also from D-type retroviruses that are associated with the simian acquired immune deficiency syndrome. Budding forms resembling incomplete nucleoids of maturing D-type retrovirus were found in neutrophils in a lymph node from another patient with prodromal AIDS. The significance of these structures is unknown.
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology / Q000473:pathology*; D000328:Adult; D000818:Animals; D017977:Deltaretrovirus / Q000648:ultrastructure; D006801:Humans; D008198:Lymph Nodes / Q000382:microbiology / Q000648:ultrastructure; D008206:Lymphatic Diseases / Q000382:microbiology / Q000473:pathology*; D008254:Macaca nemestrina; D008297:Male; D012192:Retroviridae Infections / Q000473:pathology*; D014771:Virion / Q000648:ultrastructure*