title: Dose-dependent influence of fentanyl on prolactin, growth hormone, and mood.
abstract: The effect of Fentanyl (FE), an opioid agonist, on neurosecretion and mood was investigated in normal volunteers using doses of 0.1, 0.2, 0.25 mg/70 kg. FE caused a strong dose-dependent increase in prolactin (PRL) secretion in every subject. In contrast, growth hormone (GH) was stimulated significantly at the highest dose only. Additionally, FE induced a significant increase in feeling of wellbeing measured by the Visual Analogue Scale (VAS).
mesh_terms: D000328:Adult; D004644:Emotions / Q000187:drug effects*; D005283:Fentanyl / Q000494:pharmacology*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D009489:Neurosecretion / Q000187:drug effects; D011388:Prolactin / Q000378:metabolism*; D011957:Receptors, Opioid / Q000187:drug effects
chemical_list: D011957:Receptors, Opioid; D011388:Prolactin; D013006:Growth Hormone; D005283:Fentanyl