title: Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas.
abstract: Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5' end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.
mesh_terms: D000818:Animals; D001483:Base Sequence; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004251:DNA Transposable Elements; D005814:Genes, Viral; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008979:Moloney murine leukemia virus / Q000235:genetics*; D009154:Mutation; D009693:Nucleic Acid Hybridization; D009857:Oncogenes
chemical_list: D004251:DNA Transposable Elements; D004262:DNA Restriction Enzymes