[Mechanism of the effect of anti-angina drugs with adrenergic beta receptor agonist action on the collateral hemodynamics and redistribution of the blood flow in chronic myocardial ischemia].
The experiments on dogs showed that in chronic myocardial ischaemia nonachlasine raising the retrograde arterial pressure and increasing the retrograde blood inflow to the ischaemic focus exerts a positive influence on the collateral cardiac haemodynamics. Raising the tonus of the coronary vessels in the intact regions of the myocardium to a greater extent than in the ischaemic region, nonachlasine redistributes the bloodflow to the advantage of the ischaemic zone. Oxyphedrin, decreasing of the ischaemic zone. Oxyphedrin, decreasing the tonus of the coronaries, especially in the intact areas of the myocardium, elicits the syndrome of "stealing" the zone of ischaemia.
D000318:Adrenergic beta-Agonists; D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D002908:Chronic Disease; D003097:Collateral Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D009628:Nonachlazine / Q000627:therapeutic use; D010099:Oxyfedrine / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D000318:Adrenergic beta-Agonists; D014665:Vasodilator Agents; D009628:Nonachlazine; D010099:Oxyfedrine
K mekhanizmu vliianiia antianginal'nykh sredstv s beta-adrenostimuliruiushchim komponentom deĭstviia na kollateral'nuiu gemodinamiku i pereraspredelenie krovotoka pri khronicheskoĭ ishemii miokarda.