Removal of hepatitis-B-virus infectivity from factor-IX complex by hepatitis-B immune-globulin. Experiments in chimpanzees.
Hepatitis-B-virus infectivity can be removed from a heat-labile clotting factor concentrate by the addition of hepatitis-B immune-globulin. Three chimpanzees were each inoculated with samples of factor-IX complex (factor IX) which had been deliberately contaminated with 10(3.5) chimpanzee infectious doses of hepatitis-B virus from a known infectious inoculum. Two of these factor IX samples had been incubated with hepatitis-B immune-globulin after the addition of hepatitis-B virus. 10 weeks after inoculation hepatitis-B infection developed in the chimpanzee inoculated with untreated factor IX. Hepatitis B did not develop in the two which received treated factor IX; no serloigical evidence of hepatitis B could be detected during 52 weeks of evaluation.
D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage*; D005164:Factor IX / Q000008:administration & dosage*; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology; D006509:Hepatitis B / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000008:administration & dosage*; D007106:Immune Sera / Q000008:administration & dosage*; D002679:Pan troglodytes / Q000276:immunology*; D012306:Risk
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D007106:Immune Sera; D005164:Factor IX