Guanylylimidodiphosphate enhances the vasopressin- and vasotocin-induced osmotic water flow with no effect on the sodium transport of the frog bladder.
The effects of guanylylimidodiphosphate [Gpp (NH) p] on the vasopressin- and vasotocin-induced osmotic water flow and sodium transport across the bladder of the frog, Rana catesbiana, were examined. Gpp (NH) p enhanced both the vasopressin- and vasotocin-induced water flow, while it did not affect that of the sodium transport. These results suggest that the neurohypophysial hormone-induced water flow is regulated by the guanine nucleotide regulatory site of the adenylate cyclase, while the sodium transport is not regulated at the regulatory site.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology; D004553:Electric Conductivity / Q000187:drug effects; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives*; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology*; D011892:Rana catesbeiana; D012964:Sodium / Q000502:physiology; D014667:Vasopressins / Q000494:pharmacology*; D014668:Vasotocin / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D014667:Vasopressins; D006165:Guanylyl Imidodiphosphate; D006160:Guanosine Triphosphate; D012964:Sodium; D000242:Cyclic AMP; D014668:Vasotocin