Lymphocyte monoamine oxidase and plasma prolactin and growth hormone in tardive dyskinesia.
Twelve elderly women with tardive dyskinesia were matched with 12 patients without dyskinesia. Lymphocyte monoamine oxidase (MAO) activity and plasma prolactin and growth hormone concentrations were determined "blind" in these 12 pairs of patients. Chronic schizophrenic patients with tardive dyskinesia had significantly lower lymphocyte MAO activity as compared to controls. Organic brain syndrome patients with dyskinesia did not differ from controls in the lymphocyte MAO activity. These results with lymphocyte MAO parallel our earlier findings on platelet MAO. No significant differences were found between dyskinesia group and controls in the plasma prolactin and growth hormone concentrations. Possible implications of our findings are discussed.
D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D004298:Dopamine / Q000502:physiology; D004409:Dyskinesia, Drug-Induced / Q000097:blood*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D019965:Neurocognitive Disorders / Q000097:blood / Q000188:drug therapy; D011388:Prolactin / Q000097:blood*; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy
D014150:Antipsychotic Agents; D011388:Prolactin; D013006:Growth Hormone; D008995:Monoamine Oxidase; D004298:Dopamine