Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA.
The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.
D001483:Base Sequence; D002051:Burkitt Lymphoma / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis*; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization; D010957:Plasmids; D011995:Recombination, Genetic
D004279:DNA, Viral