[Cholinergic antagonism by beta-blockers. I. Spectrum of interactions].
Complete final steady state selective antagonism by beta-blockers of different conventional classes versus acetylcholine effects on isolated frog rectus abdominis, guinea pig ileum and spontaneous beating auricles had been measured. The results do not support common beta-blockers groupings, nor binary conventional subdivision of "nicotinic" and "muscarinic" cholinergic receptors, confirming our previous findings.
D000009:Abdominal Muscles / Q000187:drug effects; D000109:Acetylcholine / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D007741:Labetalol / Q000494:pharmacology; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D010869:Pindolol / Q000031:analogs & derivatives / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013015:Sotalol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D011950:Receptors, Cholinergic; C015340:mepindolol; D011433:Propranolol; D013015:Sotalol; D010869:Pindolol; D008790:Metoprolol; D007545:Isoproterenol; D000109:Acetylcholine; D007741:Labetalol; D011217:Practolol
Antagonismi colinergici di beta - bloccanti. I. Spettri di interazione.