Residual effects of temazepam and other hypnotic compounds on cognitive function.
The morning after effects of taking single doses of three hypnotic compounds were compared in a five-group design, including the three drug conditions (temazepam, flurazepam, barbiturate), placebo, and no capsule controls. Results showed a slight superiority for temazepam over barbiturate on visual-motor and reaction time tasks. On one phase of a cognitive task, the barbiturate and flurazepam groups made more errors than the control groups. Overall, the results indicate an impairment in performance for the group taking barbiturate and a smaller impairment for the flurazepam group. No detectable impairment occurred for subjects taking temazepam.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001463:Barbiturates / Q000009:adverse effects; D003072:Cognition Disorders / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005479:Flurazepam / Q000009:adverse effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D013693:Temazepam / Q000009:adverse effects*
D014151:Anti-Anxiety Agents; D001463:Barbiturates; D006993:Hypnotics and Sedatives; D013693:Temazepam; D005479:Flurazepam