title: Ranitidine inhibits gastric acid and pepsin secretion following sham feeding.
abstract: The effect of an oral therapeutic dose of 150 mg of ranitidine on the acid and pepsin response to sham feeding and pentagastrin was examined in healthy volunteers, using a double-blind random-isation method. Gastric juice was collected up to 255 minutes after ingestion of the drug. In placebo-treated subjects, basal acid secretion rate and the secretion rate following sham feeding and injection of 6 micrograms/kg of pentagastrin were 5.3 meq/h +/- 2.0 SEM, 12.3 +/- 3.2, and 24.4 +/- 5.4, respectively. The corresponding values in ranitidine-treated subjects were 0.1 +/- 0.1, 0.5 +/- 0.2, and 3.4 +/- 1.2, respectively. The reduction of acid secretion in all three instances is statistically significant (p less than 0.025, p less than 0.05, and p less than 0.05, respectively). Basal, sham feeding-stimulated, and pentagastrin-stimulated pepsin secretion rates in the placebo-treated group were 38.4 mg/h +/- 7.0 SEM, 68.6 +/- 13.2, and 39.2 +/- 8.0, respectively. In the ranitidine-treated group, the values were 5.0 +/- 3.4, 13.2 +/- 5.6, and 19.6 +/- 5.0, respectively. The reduction of pepsin secretion during basal state and following sham feeding is statistically significant (p less than 0.005 and p less than 0.01). Thus, oral ranitidine inhibits the acid and pepsin response to sham feeding in man. Its inhibitory effect on the acid response to pentagastrin lasts for at least 4 hours.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000863:Antacids; D002986:Clinical Trials as Topic; D004435:Eating; D005260:Female; D005663:Furans / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010434:Pepsin A / Q000037:antagonists & inhibitors*; D010919:Placebos; D011480:Protease Inhibitors; D011899:Ranitidine; D012107:Research Design; D013268:Stimulation, Chemical
chemical_list: D000863:Antacids; D005663:Furans; D006635:Histamine H2 Antagonists; D010919:Placebos; D011480:Protease Inhibitors; D011899:Ranitidine; D010434:Pepsin A; D010418:Pentagastrin