Comparative study with ranitidine and cimetidine on gastric secretion in normal volunteers.
The inhibitory effect of ranitidine and cimetidine on pentagastrin stimulated volume, acid and pepsin secretion has been studied in eight healthy volunteers. Both compounds inhibit all measured components of gastric secretion in a dose dependent manner. On a molar basis ranitidine is on average 11.14 times for volume, 13.04 times for acid, and 9.74 times for pepsin secretion more potent than cimetidine as measured by the ID50-values.
D002927:Cimetidine / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005663:Furans / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D011899:Ranitidine; D012636:Secretory Rate / Q000187:drug effects
D005663:Furans; D006146:Guanidines; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine; D010434:Pepsin A; D010418:Pentagastrin