Stimulation of rat cerebellar guanosine 3',5'-cyclic monophosphate (cyclic GMP) levels: effects of amino acid antagonists.
1 The ability of glutamate, aspartate and related neuroexcitants to produce large calcium-dependent increases in the levels of guanosine 3',5'-cyclic monophosphate (cyclic GMP) in immature rat cerebellar slices has been demonstrated. 2 These effects were inhibited by selective antagonist compounds, indicating the presence of at least two types of excitatory amino acid receptor mediating the cyclic GMP response. 3 Protoveratrine also produced large increases in cyclic GMP, and this action was antagonized by L-glutamate diethylester suggesting that released endogenous glutamate, subsequently interacting with its postsynaptic receptors, is the predominant mechanism. 4 The kinetic characteristics of several of the inhibitor compounds were investigated.
D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002531:Cerebellum / Q000032:analysis* / Q000187:drug effects; D006152:Cyclic GMP / Q000032:analysis*; D005260:Female; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000494:pharmacology; D007700:Kinetics; D016202:N-Methylaspartate; D011526:Protoveratrines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D005971:Glutamates; D011526:Protoveratrines; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D006152:Cyclic GMP; D007608:Kainic Acid; D002118:Calcium