[Changes in serum parameters after oral alcohol intake in healthy men].
A short-time-study (1 to 24 hours) and a long-time-study (1 to 96 hours) after a single alcohol intake were made in 23 healthy probands. The pancreas and liver parameters as alpha-amylase, bilirubin, ASAT, ALAT, gamma-GT and GLDH in the serum were determined at regular intervals. The pancreas showed a sensitive reaction to alcohol expressed by an early rise of lipase activity. The liver enzymes of young healthy probands remained unchanged. Older probands, on the other hand, react by a distinct increase of the gamma-GT and GLDH as well as a decrease of the ASAT and ALAT. Also the enzyme quotients gamma-GT/ASAT and (ASAT + ALAT)/GLDH be obviously well suited to recognizing very early stages of liver lesion by serum examinations. For this purpose only a definite alcohol intake (I ml ethanol per kg body weight) is necessary.
D000284:Administration, Oral; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D000431:Ethanol / Q000009:adverse effects*; D005969:Glutamate Dehydrogenase / Q000097:blood; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects*; D008297:Male; D010179:Pancreas / Q000187:drug effects*; D000516:alpha-Amylases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D000431:Ethanol; D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D000516:alpha-Amylases; D001663:Bilirubin
Veränderungen von Serumparametern nach peroraler Alkoholaufnahme bei Gesunden.