[Suppression, by beta-adrenergic receptor blockade, of the sympathomimetic component of dopamine renal action in water-saline depletion].
The effects of beta-adrenergic receptor blockade on the renal action of Dopamine (DA) in hydro-saline depletion were investigated in 9 healthy subjects. The beta-adrenergic blocking treatment was performed (Propranolol hydrochloride 2.4 mg/kg b.w. per day) during the 2 days preceding the renal function studies. For other experimental details, see our previous Note (11). In the presence of beta-adrenergic blockade DA effects in hydro-saline depletion consisted of: a) an increase in both RPF and GFR; b) a decrease in sodium abnormally isoosmotic reabsorption as % of sodium distal load; c) an increase in both sodium and osmolar clearances; d) an increase in free water clearance higher than that observed in the absence of blocking treatment. Therefore, the sympathomimetic effects of DA in hydro-saline depletion appear to be suppressed by beta-adrenergic blockade. It is suggested that such sympathomimetic action of DA may be mediated by beta-presynaptic receptors of noradrenergic nerve endings.
D000319:Adrenergic beta-Antagonists; D004298:Dopamine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D009318:Natriuresis / Q000187:drug effects*; D011433:Propranolol; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D013566:Sympathomimetics
D000319:Adrenergic beta-Antagonists; D013566:Sympathomimetics; D012964:Sodium; D011433:Propranolol; D004298:Dopamine
Soppressione mediante beta-blocco della componente simpaticomimetica nell'azione renale della dopamina in deplezione idro-salina.