[Interaction between clonidine and alpha-blockers (author's transl)].
The inhibitory effects of clonidine on the heart seem to be due to stimulation of alpha 2 adrenoceptors. alpha-Adrenoceptor blocking agents with selective affinity for alpha 2-adrenoceptors antogonize these effects. Since the alpha-adrenoceptor blocking drugs which, at the usual dosage level, antagonize the hypotensive action of clonidine are unknown in man, caution should be exercised for such an association clonidine-alpha-blocker.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D003000:Clonidine / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D004285:Dogs; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D003000:Clonidine; D009638:Norepinephrine
Interactions clonidine et alpha-bloquants.