Possible mechanisms of action of nitrous oxide at the opioid receptor.
The difference between the analgesic and anesthetic effects of Nitrous Oxide (N2O) is emphasized. Evidence is presented indicating that N2O analgesia is mediated by an interaction with opioid receptors. Possible mechanisms by which so small a molecule as N2O could interact with the mu opioid receptor are proposed.
D000818:Animals; D006801:Humans; D009609:Nitrous Oxide / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D011957:Receptors, Opioid / Q000187:drug effects*; D017450:Receptors, Opioid, mu; D013329:Structure-Activity Relationship
D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D009609:Nitrous Oxide