In vitro actions of NN-dimethyl-2-aminoindane and related compounds.
The actions of 2-aminoindane, 2-amino-1,2,3,4-tetrahydronaphthalene and amphetamine and their N-methyl and NN-dimethyl derivatives on the guinea-pig ileum were compared. All, except the tertiary 2-aminoindane, inhibited the responses to electrical stimulation and it is suggested that this is not fully explained by their sympathomimetic properties. NN-Diemthyl-2-aminoindane increased these responses and caused contractions of the unstimulated ileum due to a nicotine-like action. The indane series was more effective in producing contractions of the ileum than the other compounds. The three tertiary derivatives antagonized competitively the actions of histamine on the ileum and those of 5-hydroxy-tryptamine on the rat uterus.
D000110:Acetylcholinesterase / Q000032:analysis; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D051381:Rats; D012702:Serotonin Antagonists / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects
D006633:Histamine Antagonists; D007189:Indans; D007192:Indenes; D012702:Serotonin Antagonists; D013566:Sympathomimetics; C028823:N,N-dimethyl-2-aminoindane; D000661:Amphetamine; D000110:Acetylcholinesterase