Comparison of the systemic and pulmonary vascular response to endotoxin with plasma and lung lymph lysosomal enzyme release: effect of steroid pretreatment.
We wanted to compare the systemic and pulmonary vascular response to Escherichia coli endotoxin with changes in lysosomal enzyme activity in plasma and lung lymph in the unanesthetized sheep with a lung lymph fistula. We wanted to determine whether lysosomal enzyme activity (LE) was a reliable marker of injury and LE increase appears to be different for the two systems.
D000818:Animals; D001794:Blood Pressure; D002199:Capillary Permeability; D002553:Cerebroside-Sulfatase / Q000378:metabolism*; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005966:Glucuronidase / Q000378:metabolism*; D007275:Injections, Intravenous; D008168:Lung / Q000098:blood supply*; D008196:Lymph / Q000201:enzymology; D008775:Methylprednisolone / Q000008:administration & dosage; D011292:Premedication; D012756:Sheep; D012772:Shock, Septic / Q000503:physiopathology*; D013429:Sulfatases / Q000378:metabolism*; D013897:Thoracic Duct
D004731:Endotoxins; D013429:Sulfatases; D002553:Cerebroside-Sulfatase; D005966:Glucuronidase; D008775:Methylprednisolone