Comparative clinical study of josamycin and erythromycin in pertussis.
Forty children with pertussis were treated in a randomized trial with josamycin or erythromycin. The pathogen was isolated in 15 cases by immunofluorescent antibody (IFA) technique. The clinical response of both groups was good and comparable. A 15-day course of therapy was able to eradicate the pathogen in all but one patient. Three patients showed minor side effects: diarrhea (2), rash (1).
D001886:Bordetella pertussis / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D004917:Erythromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D007933:Leucomycins / Q000627:therapeutic use*; D008297:Male; D014917:Whooping Cough / Q000188:drug therapy*
D007933:Leucomycins; D004917:Erythromycin