[Effect of magnolia vine lignans on cell division processes in the corneal and lingual epithelium of white rats subjected to long-term exposure to cold stress].
A study was made of the possibility of correcting with shizandra lignans of the cell manifestations of disadaptation in animals exposed to chronic cold stress. The stress was simulated by a 1.5-hour cooling of the animals to 28-30 degrees C for 28 days. The cell disadaptation test was used for determination of the level of pathological mitoses (PM). The processes of cell division were evaluated with the aid of the mitotic index and radioautography of DNA synthesis. Administration of shizandra to the stress-exposed animals for 28 days averted the stress-induced elevation of the PM level in the corneal epithelium. The use of shizandra lignans also promoted the normalization of DNA synthesis and mitotic activity in the tissues under examination.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003080:Cold Temperature / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D004848:Epithelium / Q000187:drug effects; D017705:Lignans; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D013312:Stress, Physiological / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D014059:Tongue / Q000187:drug effects*
D017705:Lignans; D010936:Plant Extracts
Vliianie lignanov limonnika na protsessy kletochnogo deleniia épiteliia rogovitsy i iazyka belykh krys, podvergnutykh dlitel'nomu vozdeĭstviiu kholodovogo stressa.