[Effect of the antihistamine preparation, phencarol, on the central nervous system].
The new antihistaminic and antiallergic drug phencarol (quinuclidy-3-diphenylcarbinol hydrochloride) in contradistinction to dimedrol (diphenhydramine) and diprazine (promethazin) exerts no pronounced depressant effect on the central nervous system. It does not significantly influence the period of action of hypnotic drugs, the effects produced by alcohol, spontaneous motor activity, summation capacity of the central nervous system, conditioned reflexes or electroencephalogram. That phencarol possesses no marked central action may be accounted for by its low lipophilic activity and little permeability of the blood brain barrier by this drug.
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects*; D003864:Depression, Chemical; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004569:Electroencephalography; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D051379:Mice; D011812:Quinuclidines / Q000494:pharmacology*; D051381:Rats
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D011812:Quinuclidines; C014742:quifenadine
Vliianie protivogistaminnogo preparata fenkarola na tsentral'nuiu nervunuiu sistemu.