Properties of rabies vaccine freed of neuroallergenic factor from brain tissue.
Fixed rabies virus in the form of infected sheep brain suspension was freed from approx. 80% of ballast proteins, inactivated by beta-propiolactone and lyophilized. The vaccine thus obtained was devoid of neuroallergenicity when tested on guinea pigs and was highly antigenic and immunogenic. The vaccine caused no generalized reactions in volunteers; local reactions were weak and of short duration. Antibody formation was intensive in all volunteers.
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000302:isolation & purification*; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001921:Brain / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D011819:Rabies Vaccines / Q000276:immunology* / Q000302:isolation & purification; D011820:Rabies virus / Q000276:immunology; D012756:Sheep / Q000276:immunology; D014611:Vaccination
D000485:Allergens; D000914:Antibodies, Viral; D011819:Rabies Vaccines