Effects of L-glutamate on cyclic AMP levels in slices from different areas of rat cerebral cortex with a chronic iron-induced focus.
The effect of L-glutamate of cyclic AMP levels in different areas of rat cerebral cortex was examined during the development of an iron-induced focus in the left sensorimotor cortex. The addition of L-glutamate resulted in increased cyclic AMP levels in slices from the quarter of cortex with the iron-induced focus. The levels lowered in slices from the quarter of cortex most remote from the focus. Thus L-glutamate showed stimulatory and inhibitory effects on the accumulation of cyclic AMP.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D002712:Chlorides; D000242:Cyclic AMP / Q000378:metabolism*; D004828:Epilepsies, Partial / Q000139:chemically induced* / Q000378:metabolism; D005290:Ferric Compounds; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D066298:In Vitro Techniques; D007501:Iron; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002712:Chlorides; D005290:Ferric Compounds; D005971:Glutamates; D018698:Glutamic Acid; D000242:Cyclic AMP; D007501:Iron; C024555:ferric chloride