[The dynamics of drug release from suppositories. Part 6: The effects of lipophil and hydrophilic suppository bases on the release of adeiphenin (author's transl)].
On studying the release of adiphenin from suppositories, the authors found that it is most rapid from hydrophilic bases. The release rate decreased in the following order: PEG 1500 leads to PEG 2000 leads to PEG 4000 (70%) + Glycerol (30%) leads to PEG 1000 (70%) + Peg 4000 (30%) leads to PEG 4000 leads to PEG 6000. The release is considerably slower from the bases Witepsol W35, Witepsol H15 and cacao butter.
D055598:Chemical Phenomena; D002621:Chemistry; D004058:Diffusion; D004158:Diphenylacetic Acids; D007700:Kinetics; D014677:Pharmaceutical Vehicles; D011092:Polyethylene Glycols; D012995:Solubility; D013488:Suppositories
D004158:Diphenylacetic Acids; D014677:Pharmaceutical Vehicles; D013488:Suppositories; D011092:Polyethylene Glycols
Dynamik der Arzneimittelabgabe aus Suppositorien. 6. Mitteilung: Einfluss lipophiler und hydrophiler Zäpfchengrundlagen auf die Liberation von Adiphenin.