gamma-D-Glutamylaminomethylsulphonic acid (GAMS), a kainate and quisqualate antagonist, prevents sound-induced seizures in DBA/2 mice.
The effect of gamma-D-glutamylaminomethylsulphonic acid (GAMS) on sound-induced seizures has been assessed in DBA/2 mice. All phases of the seizure response are suppressed following intracerebroventricular injection (ED50 values: 0.077 mumol for tonic seizure, 0.132 mumol for wild running) or intraperitoneal injection (ED50: 1.21 mmol/kg for tonic seizure, 4.95 mmol/kg for wild running). The results are discussed in relation to the involvement of 'kainate' and 'quisqualate' receptors in the generation and propagation of seizures.
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants; D001921:Brain / Q000503:physiopathology; D005260:Female; D005971:Glutamates / Q000627:therapeutic use*; D005973:Glutamine / Q000031:analogs & derivatives*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D018091:Receptors, AMPA; D011955:Receptors, Drug / Q000502:physiology; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter / Q000502:physiology; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control*
D000927:Anticonvulsants; D005971:Glutamates; D005973:Glutamine; D018091:Receptors, AMPA; D011955:Receptors, Drug; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter; C042626:gamma-glutamylaminomethylsulfonic acid