[Secretion of aldosterone and corticosterone by the adrenals of Brattleboro rats in response to ACTH administration].
The secretions of aldosterone and corticosterone in response to administration of 0,5 mUI of (1,24) ACTH (synacthène-Ciba) were measured in the adrenal venous blood of 15 Brattleboro female rats genetically lacking vasopressin and in 15 Long-Evans female rats, pretreated with dexamethasone. The secretions of aldosterone and corticosterone increased according to a similar profile in the two groups of animals: maximum values were 20-30 min. after ACTH injection; however the steroidogenic secretion of the adrenal cortex was always about 50% less in the Brattleboro female rats than in Long-Evans female rats. This result suggests mainly that vasopressin may be involved in the mechanisms which control the in vivo production of aldosterone by the adrenal glomerulosa cells.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D005260:Female; D051381:Rats; D011910:Rats, Brattleboro
D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
Sécrétions d'aldostérone et de corticostérone par la surrénale du Rat Brattleboro en réponse à l'administration d'ACTH.