Evidence for the activation of the endogenous opiate system in hamsters infected with human blood flukes, Schistosoma mansoni.
Nociceptive thresholds were investigated in golden hamsters infected with the human blood fluke, Schistosoma mansoni. Increases in thermal thresholds suggestive of analgesia were evident by 20-25 days of infection. These increased further during a 40-42 day period. The altered responses were suppressed by the opioid antagonist naloxone. Non-invasive inhibition of the activity of the pineal gland by exposure to light also reduced nocturnal analgesia in schistosome infected animals. Naloxone antagonism and pineal inhibition of morphine- induced analgesia was obtained similarly in control, uninfected animals. Taken together, these findings suggest strongly that infection with S. mansoni results in a chronic activation of the endogenous opiate system.
D000698:Analgesia; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D006224:Cricetinae; D007700:Kinetics; D008297:Male; D008550:Melatonin / Q000378:metabolism; D008647:Mesocricetus; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010870:Pineal Gland / Q000502:physiology / Q000503:physiopathology; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000378:metabolism*; D013997:Time Factors
D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine; D008550:Melatonin