Evidence against significant resting alpha-adrenergic coronary vasoconstrictor tone.
The importance of sympathetically mediated coronary vasoconstrictor tone as a determinant of resting coronary blood flow was assessed in the conscious dog by comparing blood flow and oxygen extraction in a normally innervated (I) and a previously sympathectomized (Sx) region of the same left ventricle. The regional ventricular sympathectomy was achieved by the topical application of phenol. The animals were well acclimated to the laboratory environment before regional myocardial blood flow was measured with microspheres or regional myocardial oxygen extraction was determined on blood sampled from chronically implanted coronary venous catheters. Results indicated that blood flow and oxygen extraction were not significantly different in I and Sx regions under these conditions. Regional blood flow data obtained after beta-adrenergic blockade or combined alpha- and beta-adrenergic blockade were not significantly different from control data. Thus we were unable to confirm previous evidence in the literature of significant resting sympathetic coronary vasoconstrictor tone in the conscious animal.
D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D006352:Heart Ventricles / Q000294:innervation; D009638:Norepinephrine / Q000378:metabolism; D010101:Oxygen Consumption; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D012039:Regional Blood Flow; D013562:Sympathectomy; D014661:Vasoconstriction
D011942:Receptors, Adrenergic, alpha; D009638:Norepinephrine