The effect of triazole on RNA viruses.
The triazole derivative 4-(1-hydroxy-3-piperid-N-yl-prop-l-yl)-5-methyl-2-methyl-2-phenyl-triazole (HMPT) markedly reduced plaque formation by, RNA bacteriophages and delayed their liberation. Replication of tobacco mosaic virus in a systemic host was hardly affected by HMPT, but local lesion formation in a hypersensitive host was strongly reduced by the drug. The mechanism of action of HMPT was discussed.
D000998:Antiviral Agents; D010880:Piperidines / Q000494:pharmacology; D012317:RNA Phages / Q000187:drug effects* / Q000254:growth & development; D014027:Tobacco Mosaic Virus / Q000187:drug effects* / Q000254:growth & development; D014230:Triazoles / Q000494:pharmacology*; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D010880:Piperidines; D014230:Triazoles