[Effect of the beta-adrenoblocker alpheprol and the alpha-adrenolytic tropaphen on tolerance to strophanthin in experimental myocardial infarct].
The tolerance to strophanthin was studied in acute and subacute experiments on 76 cats at varying time after occlusion of the coronary artery branch. The beta-adrenoblocker alpheprol completely smoothed away the hypersensitivity to strophanthin after the coronary blood flow cessation while the alpha-adrenolytic tropaphen virtually did not affect the tolerance to strophanthin in intact animals even after experimental myocardial infarction.
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000526:Alprenolol / Q000008:administration & dosage*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D002415:Cats; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy*; D010042:Ouabain / Q000008:administration & dosage* / Q000009:adverse effects; D010666:Phenylpropionates / Q000008:administration & dosage; D014326:Tropanes / Q000008:administration & dosage*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D010666:Phenylpropionates; D014326:Tropanes; D010042:Ouabain; C009599:tropodifene; D000526:Alprenolol
Vliianie beta-adrenoblokatora alfeprola i alpha-adrenolitika tropafena na tolerantnost' k strofantinu pri éksperimental'nom infarkte miokarda.