[Role of the adrenolytic properties of neuroleptics in their effects on ethanol addiction].
It has been shown in castrated male white rats that testosterone exerts a prolonged selective stimulant effect on the course of experimental alcoholism. The experimental ethanol addiction was suppressed by psychotropic substances that decrease the androgenic status of the organism. It is assumed that the inhibitory effect of neuroleptics on ethanol addiction seen in these experiments is mediated by their adrenolytic rather than antidopaminergic properties.
D000437:Alcoholism / Q000188:drug therapy*; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002369:Castration; D003534:Cyproterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D017373:Cyproterone Acetate; D006801:Humans; D008297:Male; D010640:Phenothiazines / Q000627:therapeutic use; D051381:Rats; D013469:Sulpiride / Q000627:therapeutic use; D013565:Sympatholytics / Q000627:therapeutic use*; D013739:Testosterone / Q000037:antagonists & inhibitors
D014150:Antipsychotic Agents; D010640:Phenothiazines; D013565:Sympatholytics; C001228:fluoracizine; D013739:Testosterone; D017373:Cyproterone Acetate; D013469:Sulpiride; D003534:Cyproterone
Znachenie adrenoliticheskikh svoĭstv neĭroleptikov v ikh vliianii na pristrastie k étanolu.