[Age dependency of normal and modified nucleobases in urine in correlation to growth velocity (author's transl)].
Up to now no age-correlated normal values of normal and modified nucleobases in urine have been published. In this paper such normal values are presented, obtained from 116 healthy subjects from 0 to 16 years by high performance liquid chromatography of creatinine-correlated single urine specimens. A narrow correlation between the excretion of nucleobases and growth velocity was found. A polynomial function including the puberal growth spurt could be fitted to the analytical data. It is felt that this method should be suitable to assess growth processes of different kinds, e.g. effects of nutrition or drugs and hormones on growth velocity, furthermore intrauterine and malignant growth.
D000225:Adenine / Q000652:urine; D000293:Adolescent; D000367:Age Factors; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D003596:Cytosine / Q000652:urine; D005260:Female; D006128:Growth; D006147:Guanine / Q000652:urine; D006801:Humans; D007223:Infant; D008297:Male; D008433:Mathematics; D009705:Nucleosides / Q000652:urine*; D011627:Puberty; D012016:Reference Values; D013941:Thymine / Q000652:urine; D014498:Uracil / Q000652:urine
D009705:Nucleosides; D014498:Uracil; D006147:Guanine; D003596:Cytosine; D003404:Creatinine; D000225:Adenine; D013941:Thymine
Die Altersabhängigkeit der normalen und modifizierten Nucleobasen im Urin als Ausdruck der Wachstumsgeschwindigkeit.