[Free radicals and oxidative phosphorylation in chemical carcinogenesis].
Rat liver mitochondria were investigated at DEN induced chemical cancerogenesis. The intensity of ESR signal (g = 2.00) at 77 K was measured in parallel with respiratory control indicating the relationship between oxidation and ATP synthesis levels. Correlation between these values was obtained. Consequently the change of ESR signal (g = 2.00) intensity at cancerogenesis may be to a great extent associated with the state of the coupling system in mitochondria.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004052:Diethylnitrosamine; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D008930:Mitochondria, Liver / Q000378:metabolism*; D009369:Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D010085:Oxidative Phosphorylation; D051381:Rats
D005609:Free Radicals; D002084:Butylated Hydroxytoluene; D004052:Diethylnitrosamine
Svobodnye radikaly i okislitel'noe fosforilirovanie pri khimicheskom kantserogeneze.