Oral treatment of haemophilia A by gastrointestinal absorption of factor VIII entrapped in liposomes.
Factor-VIII-loaded liposomes were given orally to a patient with severe haemophilia A. Plasma concentrations of factor VIII rose to therapeutically effective levels, that persisted for 50 hours.
D000284:Administration, Oral; D001682:Biological Availability; D005169:Factor VIII / Q000008:administration & dosage* / Q000378:metabolism; D006467:Hemophilia A / Q000628:therapy*; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008081:Liposomes / Q000008:administration & dosage*; D013997:Time Factors
D008081:Liposomes; D005169:Factor VIII