title: Effect of excitatory amino acid antagonists on the high pressure neurological syndrome in rats.
abstract: The onset pressures for the tremor, myoclonus and convulsions seen in the high pressure neurological syndrome (HPNS) are increased following cis-2,3-piperidine dicarboxylic acid 1 mmol/kg in the rat. Glutamic acid diethyl ester 1-3 mmol/kg has no effect on tremor or myoclonus, but increases the convulsion pressure when 3 mmol/kg is given immediately before compression. These and earlier data with 2-amino-7-phosphonoheptanoic acid suggest that excitation at the N-methyl-D-aspartate receptor is important in HPNS tremor, and that excitation at the quisqualate receptor contributes to HPNS convulsions.
mesh_terms: D000818:Animals; D005971:Glutamates / Q000627:therapeutic use*; D008297:Male; D009207:Myoclonus / Q000517:prevention & control*; D010875:Pipecolic Acids / Q000627:therapeutic use*; D011312:Pressure / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012640:Seizures / Q000517:prevention & control*; D013577:Syndrome; D014202:Tremor / Q000517:prevention & control*
chemical_list: D005971:Glutamates; D010875:Pipecolic Acids; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C011829:glutamic acid diethyl ester; C029262:2,3-piperidinedicarboxylic acid