[Effects of anti-MB and anti-DR monoclonal antibodies on in vitro immune responses].
The present study has addressed the effects of anti-DR and anti-MB monoclonal antibodies on various in vitro immune responses. The anti-DR monoclonal antibody HU-4 was found to inhibit T cell proliferative responses to PPD, autologous non-T cells, autologous EB-virus-transformed B cells, and alloantigens. Furthermore, HU-4 strongly inhibited generation of killer T cells specific for autologous EB-virus-transformed B cells and alloantigens. In contrast, the anti-MB monoclonal antibody HU-18 did not affect any of these in vitro responses to a significant degree, and its effect was largely comparable to that of a class I specific monoclonal antibody. Thus, these results indicate that DR rather than MB antigens play a major role in the in vitro systems studied in this investigation. Possible implications of these observations were discussed by comparing our results with those known in mice.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D002455:Cell Division / Q000187:drug effects; D002472:Cell Transformation, Viral; D006684:HLA-DR Antigens; D004854:Herpesvirus 4, Human; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II