n-Pentylamine: effect on motor activity of mice.
Motor and autonomic effects of n-pentylamine in mice have been evaluated in relation to aminergic mechanisms by combining administration of the amine with drugs having well known effects on such mechanisms. Some evidence has been found to indicate the importance of dopaminergic pathways in the actions of pentylamine; these actions are modifiable by central blockade of muscarinic receptors with atropine. Serotonin-regulated pathways do not seem important for the effects of pentylamine that have been studied.
D000588:Amines / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010643:Phenoxybenzamine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology
D000588:Amines; D014150:Antipsychotic Agents; D008781:Methyltyrosines; D010643:Phenoxybenzamine; D001285:Atropine; D012110:Reserpine; C005264:n-amylamine; D010134:Fenclonine; D004221:Disulfiram