title: The coding region of the human c-mos pseudogene contains Alu repeat insertions.
abstract: We have determined the nucleotide sequence of an 841-bp fragment derived from a segment of the human genome previously cloned by Chumakov et al. [Gene 17 (1982) 19-26] and Zabarovsky et al. [Gene 23 (1983) 379-384] and containing regions homologous to the viral mos gene probe. This sequence displays homology with part of the coding region of the human and murine c-mos genes, contains several termination codons, and is interrupted by two Alu-family elements flanked by short direct repeats. Probably, the progenitor of the human c-mos gene was duplicated approximately at the time of mammalian divergence, was converted to a pseudogene, and acquired insertions of two Alu elements.
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics; D004251:DNA Transposable Elements; D005784:Gene Amplification; D006801:Humans; D009857:Oncogenes; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004251:DNA Transposable Elements; D004247:DNA