Inhibition of gastric acid secretion in the dog by the histamine H2-receptor antagonists ranitidine and cimetidine.
The H2-receptor antagonists ranitidine and cimetidine inhibit gastric acid secretion elicited by a test meal in the dog. Ranitidine is approxiamtely 10 times more potent than cimetidine in this respect.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D004285:Dogs; D005750:Gastric Juice / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D012636:Secretory Rate / Q000187:drug effects
D006146:Guanidines; D006635:Histamine H2 Antagonists; D002927:Cimetidine