Metabolic activation of human neutrophils by fluid-phase and particle-bound ligands.
The ability of particle-bound and fluid-phase ligands (IgG, C3b, and ConA) to induce metabolic activation in cytochalasin B-treated human neutrophils was studied. Different activation mechanisms of the neutrophils are proposed, since the activation of cytochalasin B-treated neutrophils is not dependent on whether or not the ligands are particle-bound but not on the nature of ligand per se.
D003179:Complement C3b / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology*; D003571:Cytochalasin B / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008024:Ligands; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D012995:Solubility; D013481:Superoxides / Q000096:biosynthesis
D007074:Immunoglobulin G; D008024:Ligands; D003208:Concanavalin A; D013481:Superoxides; D003571:Cytochalasin B; D003179:Complement C3b