Herpes simplex virus genital infection of the female guinea pig as a model for the evaluation of an experimental vaccine.
Substantial protection against herpes simplex type 2 (HSV 2) infection of the female guinea pig genital tract was provided by immunization with an experimental HSV 2 vaccine prepared from the plasma membranes of infected MRC-5 cells. Protection was evaluated in terms of the modification of histopathological lesions and clinical signs and in changes in viral replication and serological responses in vaccinated and control animals.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004195:Disease Models, Animal; D004848:Epithelium / Q000382:microbiology / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D018139:Simplexvirus / Q000276:immunology*; D014621:Vagina / Q000382:microbiology / Q000473:pathology; D014626:Vaginal Smears; D014765:Viral Vaccines / Q000008:administration & dosage*
D000914:Antibodies, Viral; D014765:Viral Vaccines