Epsilon amino caproic acid myopathy: additional features.
In a patient with a proximal myopathy due to Epsilon Amino Caproic Acid (EACA) bedrest led to marked improvement even before withdrawal of the drug. A biopsy showed a selective necrosis of type I fibers. Plasma level of EACA was low and plasma level of lysine was normal. A 99mTechnetium-MDP showed marked uptake in the affected muscles, whereas a 67Gallium scan was negative.
D000410:Alanine Transaminase / Q000097:blood; D000614:Aminocaproates / Q000009:adverse effects*; D015119:Aminocaproic Acid / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000150:complications; D003402:Creatine Kinase / Q000097:blood; D006469:Hemoptysis / Q000188:drug therapy; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects; D009336:Necrosis; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000201:enzymology
D000614:Aminocaproates; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D015119:Aminocaproic Acid