title: Increase in rat cortical [3H]naloxone binding site density after chronic administration of antidepressant agents.
abstract: Given chronically, the first and second generation antidepressants imipramine and citalopram, and antidepressant neuroleptics levomepromazine and chlorprothixene, elevated moderately but significantly (by 15-30%) the density of [3H]naloxone binding sites in rat cerebral cortical membranes. There were only small non-significant changes in Kd values.
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000378:metabolism*; D002749:Chlorprothixene / Q000494:pharmacology; D015283:Citalopram; D007099:Imipramine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008728:Methotrimeprazine / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000928:Antidepressive Agents; D011437:Propylamines; D011957:Receptors, Opioid; C034565:naloxone receptor; D015283:Citalopram; D008728:Methotrimeprazine; D002749:Chlorprothixene; D007099:Imipramine