Cyclic nucleotide changes and contractility in the rat anococcygeus muscle.
The rat anococcygeus muscle can be activated by three different agonists, NA, ACh and KCl, each of these displaying a different degree of pharmacomechanical coupling. Investigation of cyclic nucleotide changes in the muscles when activated showed that changes in cAMP/cGMP ratio parallel changes in contractility. However, the cyclic nucleotide changes seem incidental to the process of contraction, rather than causally related to it.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D009124:Muscle Proteins; D011189:Potassium Chloride; D000242:Cyclic AMP; D006152:Cyclic GMP; D000109:Acetylcholine; D002118:Calcium; D009638:Norepinephrine