Effects of superoxide anions on the (Na + K)ATPase system in rat lung.
Oxygen-derived free radicals have been shown to alter endothelial cell functions in lung. Enzymatically generated superoxide anions inactivated (Na + K)ATPase activity and caused lipid peroxidation in lung. Superoxide dismutase or allopurinol, but not ATP, protected this oxy radical-mediated depression of ATPase activity.
D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D008054:Lipid Peroxides / Q000096:biosynthesis; D008168:Lung / Q000201:enzymology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008861:Microsomes / Q000201:enzymology; D010477:Perfusion; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000494:pharmacology*
D005609:Free Radicals; D008054:Lipid Peroxides; D013481:Superoxides; D008315:Malondialdehyde; D000493:Allopurinol; D013482:Superoxide Dismutase; D000254:Sodium-Potassium-Exchanging ATPase; D005978:Glutathione