title: Immunobiology of molar pregnancy and gestational trophoblastic tumors.
abstract: Because all the chromosomes in complete molar pregnancy are of paternal origin, complete moles are complete allografts (transplants). Complete moles may therefore be expected to induce a vigorous maternal host immunologic response. Further understanding of the relationships between the normal placenta, mole and choriocarcinoma may provide important insights into the basic mechanisms of teratogenesis and carcinogenesis.
mesh_terms: D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology; D002822:Choriocarcinoma / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics / Q000276:immunology*; D007109:Immunity; D007111:Immunity, Cellular; D007621:Karyotyping; D011247:Pregnancy; D014184:Transplantation, Homologous; D014328:Trophoblastic Neoplasms / Q000276:immunology*; D014594:Uterine Neoplasms / Q000235:genetics / Q000276:immunology*
chemical_list: D000936:Antigen-Antibody Complex; D006680:HLA Antigens