Squamous cell carcinoma of the vulva and Fanconi anemia.
Malignant neoplasia frequently occurs with Fanconi anemia. Generally this represents hematologic disease; however, solid tumors may also appear. The woman described here developed squamous cell carcinoma of the vulva at age 28, and is the third such case in a patient with Fanconi anemia that has been reported. It is a diagnosis to be considered for the young patient with this type of carcinoma. Increased chromosomal breakage in this syndrome may be important in the pathogenesis of these neoplastic changes.
D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D005199:Fanconi Anemia / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D014846:Vulvar Neoplasms / Q000150:complications*