[Pharmacokinetics of pindolol in a group of elderly hypertensive patients (author's transl)].
A pharmacokinetic investigation was carried out on a group of 13 elderly patients (2 males, 11 females, mean age 79 years) who were either mildly hypertensive or had a history of hypertension. The aim of the study was to determine and compare the plasma concentrations, urinary excretion and pharmacokinetic parameters of pindolol (Visken) after a single oral dose and in steady-state. Each patient received 10 mg (two 5 mg tablets in one dose) of pindolol daily for 7 days. Blood plasma and urine samples were obtained for up to 24 h after administration on days 1 and 7, blood pressure and pulse rate were also taken on the same days. The pharmacokinetic parameters and the effects on blood pressure and pulse rate of pindolol after 7 days of treatment showed no statistical difference to those recorded after a single dose. Kinetic data in this group did not differ from findings recorded in previous studies conducted on younger subjects. Results of this study indicate that pindolol does not accumulate on repeated administration to older patients. Therefore no adjustment of the usual dosage is necessary when prescribing for this age group. Finally the problems concerning pharmacokinetic investigations in elderly patients are discussed.
D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000378:metabolism* / Q000627:therapeutic use
D010869:Pindolol
Pharmakokinetik von Pindolol bei einer Gruppe älterer Hypertoniker.