title: The dopaminergic system in the periphery.
abstract: Peripheral dopaminergic effects are manifold. We have listed the main ones, but DA may also have a vasodilatory effect on brain arteries, may stimulate parathormone secretion and prevent the formation of experimental gastric ulcers. For the practitioner, a balanced association of the alpha- and beta-adrenergic and D1 and D2 dopaminergic effects might be useful. For the pharmacologist and the basic research worker, the quest for selective D1 and D2 agonists is a valid one. The results obtained so far justify this effort without however guaranteeing its success. Binding techniques which have proved so fruitful in other domains, have not yielded the expected results because there are no highly specific ligands. Structure activity relationships are at a standstill. It appears that no single model rationalizes agonist activity of all classes of DA agents. Some of the speculation concerning superpositions of ergolines and apomorphines should bring home to medicinal chemists the need to see these molecules less through the eyes of the printer, for whom benzene appears as a hexagon with formal kekule bonds, and more as the receptor "sees" them, namely in terms of electrostatic fields and electron densities (Nichols, 1983).
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D018492:Dopamine Antagonists; D006439:Hemodynamics / Q000187:drug effects; D007677:Kidney Function Tests; D009318:Natriuresis / Q000187:drug effects; D009411:Nerve Endings / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D011954:Receptors, Dopamine / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000097:blood; D009435:Synaptic Transmission / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
chemical_list: D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D017981:Receptors, Neurotransmitter; D012083:Renin; D004298:Dopamine; D009638:Norepinephrine