[Effect of new antihistaminic preparations on the body's immunologic reactivity].
The effect of new antihistaminic drugs, phencarol and bicarphen, on immunologic reactivity of experimental animals was studied in comparison with diphenhydramine. Phencarol and bicarphen inhibited the delayed type allergic reactions to a greater degree than diphenydramine. Unlike diphenhydramine, phencarol and bicarphen injected simultaneously with test-antigen markedly decreased the number of rosette-forming lymphocytes in the immunocompetent organs (spleen, thymus, lymph nodes). Phencarol, bicarphen and diphenhydramine produced the same inhibitory effect on the content of antibody-producing cells in the spleen of mice.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004137:Dinitrochlorobenzene; D004155:Diphenhydramine / Q000494:pharmacology*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed; D007109:Immunity / Q000187:drug effects*; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011812:Quinuclidines / Q000494:pharmacology*; D012397:Rosette Formation
D001559:Benzhydryl Compounds; D004137:Dinitrochlorobenzene; D006634:Histamine H1 Antagonists; D007166:Immunosuppressive Agents; D011812:Quinuclidines; C018139:bicarphene; D004155:Diphenhydramine; C014742:quifenadine
Vliianie novykh protivogistaminovykh preparatov na immunologicheskuiu reaktivnost' organizma.