[Effect of the association of inhibitors of the H 1 and H 2 histamine receptors in the mechanism of rupture of the gastric barrier in the dog in vivo].
Two specific inhibitors of histamine receptors, H1 mepiramine (Mp) and H2 cimetidine (Cm), were used in combination to define the role of histamine in the mechanisms of gastric barrier rupture in the dog "in vivo". A gastrolesive substance butyric acid (Ac.B. 75 mM) in hydrocloric acid solution (HCl 75 mM) was perfused through Heidenhain pouches in the presence or absence of Mp (10 mg/Kg i.m.) and Cm (1 mg/Kg/h i.v.). The results obtained showed: 1) Ac.B. caused a remarkable increase in H+ and Na+ fluxes, enhanced K+ secretion and decreased transparietal potential difference (D.P.). 2) Histamine inhibitors in combination uneffected changes of the ionic fluxes and D.P. produced by Ac.B. 3) Reversal to normal of both ionic fluxes and D.P. was not accelerated by the combination of Mp and Cm. The conclusion was reached that in the initial phase of gastric barrier rupture damage of gastric mucosa occurs by mechanisms non histamine-dependent.
D000818:Animals; D004285:Dogs; D004338:Drug Combinations; D005753:Gastric Mucosa / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects* / Q000502:physiology
D004338:Drug Combinations; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists
Effetto dell'associazione di inibitori dei recettori H1 e H2 dell'istamina nei meccanismi di rottura della barriera gastrica del cane "in vivo".