JC virus enhancer-promoter active in human brain cells.
A human papovavirus, JCV, is the etiologic agent of the fatal demyelinating disease, progressive multifocal leukoencephalopathy. The JCV 98-base-pair tandem repeats, located to the late side of the viral replication origin, were shown to be a transcriptional regulatory element with enhancer-like activity in human fetal glial cells. These tandem repeats share significant homology with the 82-nucleotide rat brain-specific identifier RNA sequence.
D001483:Base Sequence; D001921:Brain / Q000382:microbiology*; D005333:Fetus; D005784:Gene Amplification; D005786:Gene Expression Regulation; D005814:Genes, Viral; D006801:Humans; D007577:JC Virus / Q000235:genetics*; D009457:Neuroglia / Q000382:microbiology; D009876:Operon; D011120:Polyomavirus / Q000235:genetics*