[Control of the intragastric pH value in infection and peritonitis by ranitidine versus cimetidine. A double-blind study].
12 patients of an intensive care unit on respirator with peritonitis respectively septic complications were treated with 300 mg/die Ranitidine or 2000 mg Cimetidine/die administered via perfusor infusion under the conditions of a randomized double blind study. Both groups under investigation were comparable in respect to age, sex and grade of risk of stress induced bleedings. With ranitidine under the dosage mentioned above, a prophylactic sufficient control, yet not a complete control of intragastric pH-value was accomplished. With Cimetidine as monotherapy, however, even under the high dosage of 2000 mg/die, no successful control of the intragastric pH could be achieved. With 3 patients even the combinations of 2000 mg Cimetidine/die and 2 X 10 mg Pirenzepine/die did not prove sufficient. Especially for intensive care patients with a difficult to regulate intragastric pH (patients with peritonitis, sepsis) Ranitidine according to our findings is to prefer to Cimetidine for the prophylaxis of bleeding of gastroduodenal lesions.
D000038:Abscess / Q000150:complications; D000293:Adolescent; D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003422:Critical Care; D004311:Double-Blind Method; D005745:Gastric Acidity Determination; D006801:Humans; D008875:Middle Aged; D010437:Peptic Ulcer / Q000517:prevention & control*; D010538:Peritonitis / Q000150:complications*; D011899:Ranitidine / Q000627:therapeutic use*; D018805:Sepsis / Q000150:complications; D013530:Surgical Wound Infection / Q000150:complications*
D002927:Cimetidine; D011899:Ranitidine
Kontrolle des intragastralen pH-Wertes bei Sepsis bzw. Peritonitis durch Ranitidin versus Cimetidin--Eine Doppelblindstudie.