Reduction by aspirin of intestinal fluid-loss in acute childhood gastroenteritis.
Soluble aspirin was given by mouth in therapeutic doses in a double-blind trial to malnourished infants and young children with gastroenteritis and dehydration. Faecal fluid-losses were reduced and weight-grain was enhanced in the group given aspirin. These effects were statistically significant when compared with those obtained with a placebo preparation and in a group of patients given supportive therapy but no specific drug treatment. The results suggest that aspirin may be useful in reducing intestinal fluid-loss in childhood gastroenteritis. Before the widespread use of aspirin can be recommended, its effects in patients not under hospital supervision must be determined.
D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D001424:Bacterial Infections; D001835:Body Weight / Q000187:drug effects; D002986:Clinical Trials as Topic; D003681:Dehydration / Q000517:prevention & control*; D003968:Diarrhea, Infantile / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007223:Infant; D007419:Intestinal Secretions / Q000187:drug effects; D008297:Male; D012636:Secretory Rate / Q000187:drug effects
D001241:Aspirin