Effect of ketamine hydrochloride on the activity of Na+-K+ ATPase in the synaptosomal fraction of rat brain.
Ketamine produced a significant reduction in synaptosomal Na+-K+ ATPase activity both in vivo as well as in vitro. The in vitro inhibition was non-competitive. The observed inhibition of this enzyme may play a significant role in the neurotransmitter events at synapses.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D005260:Female; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology*; D007700:Kinetics; D009411:Nerve Endings / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000201:enzymology*; D013997:Time Factors
D018377:Neurotransmitter Agents; D007649:Ketamine; D000254:Sodium-Potassium-Exchanging ATPase