title: Influenza and schizophrenia: a possible connection with the substantia nigra.
abstract: The neurovirulent influenza virus of the 1918 pandemic induced clinical schizophrenia. The biochemistry, the neurovascular anatomy, the afferent connections, and the efferent connections of the substantia nigra suggest that a (Na+K)-ATPase injury could be a cause of some positive schizophrenias. The genetic trait in schizophrenia may be an inheritable susceptibility to an infectious agent.
mesh_terms: D006801:Humans; D007251:Influenza, Human / Q000150:complications / Q000503:physiopathology*; D008094:Lithium / Q000627:therapeutic use; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013378:Substantia Nigra / Q000503:physiopathology*
chemical_list: D008094:Lithium; D000254:Sodium-Potassium-Exchanging ATPase