The graft-versus-host reaction in the rabbit spleen. Ultrastructural evidence for two differentiated T-cell lines.
Lethally irradiated (900 rads), bone-marrow-protected rabbits were given allogeneic thymocytes intravenously. Autoradiography by means of local splenic infusion of (H3) thymidine revealed progeny of two differentiated T-cell lines. Electron microscopy confirmed these observations in detail. An analogy with cellular immunity reactions in an "isolated T-cell system", performed in draining lymph nodes after a variety of antigenic stimuli is presented. The functional properties of these T-blasts and their lymphoid descendants are discussed.
D000818:Animals; D001345:Autoradiography; D002460:Cell Line; D006087:Graft vs Host Reaction; D007111:Immunity, Cellular; D008854:Microscopy, Electron; D011817:Rabbits; D013154:Spleen / Q000648:ultrastructure*; D013601:T-Lymphocytes / Q000637:transplantation / Q000648:ultrastructure*; D014184:Transplantation, Homologous