[An autopsy case of carcinomatous subacute cerebellar degeneration--on distribution of cerebellar cortical lesions].
A 46-year-old man developed sudden dysarthria and atactic gait and was noted to be unable to get up even on the bed about one year prior to his death. By following several days, he started to have scanning speech, nausea, trancal ataxia and dysmetria in succession. The cerebro-spinal fluid yielded moderate pleocytosis. There were no sensory disturbance, pathological reflexes and Romberg's sign. Half a year later, submandibular tumor was noted. The biopsy showed metastatic small cell undifferentiated carcinoma, presumably of pulmonary origin, and paraneoplastic cerebellar degeneration was suspected. He died of bronchopneumonia, superimposed on lung cancer on February 25 in 1979. The necropsy showed a large tumor in the right lung which was histologically verified small cell undifferentiated carcinoma (so-called oat-cell carcinoma). The cerebellum disclosed diffuse cortical atrophy, chiefly of Purkinje cell type. Moderate demyelination with reparative gliosis and foamy macrophages was seen in the white matter, which was considered secondary to cortical devastation. The morphometric study on Purkinje cell loss showed interesting distribution of the lesions. The severely affected portions were the central lobe and culmen in the vermis, and the ala lobuli centralis and quadrangular lobe in the hemisphere, respectively. The lingula was strikingly spared. The finding was compared with that of other cerebellar disease in reviewing the literature.
D018288:Carcinoma, Small Cell / Q000150:complications* / Q000648:ultrastructure; D002525:Cerebellar Cortex / Q000473:pathology*; D002526:Cerebellar Diseases / Q000150:complications / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000648:ultrastructure; D008198:Lymph Nodes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D011689:Purkinje Cells / Q000473:pathology