Complementation of an adenovirus 5 immediate early mutant by human cytomegalovirus.
The initiation of the lytic cycle of adenovirus 5 requires synthesis of a transcriptional activator encoded by the viral early genetic unit, E1a. Mutant viruses lacking E1a are defective. Human cytomegalovirus activated transcription of early adenovirus genes and complemented an E1a- adenovirus mutant in cells permissive for both viruses.
D000260:Adenoviruses, Human / Q000235:genetics*; D002460:Cell Line; D003587:Cytomegalovirus / Q000235:genetics*; D005796:Genes; D005814:Genes, Viral; D005816:Genetic Complementation Test; D006801:Humans; D008168:Lung; D009154:Mutation; D012367:RNA, Viral / Q000302:isolation & purification; D014158:Transcription, Genetic
D012367:RNA, Viral