The activity of cefotaxime and desacetylcefotaxime against Bacteroides species compared to 7-methoxy cephems and other anti-anaerobe drugs.
The combination of cefotaxime and desacetylcefotaxime was tested against 83 Bacteroides strains (seven species) isolated from several hospitals. The combination greatly enhanced the anti-anaerobic spectrum of cefotaxime: 79.7% of tested strains were synergistically killed by the combination. Although the combination appears clinically efficacious, it is only comparable to cefoxitin and still less active than clindamycin, chloramphenicol and metronidazole.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001439:Bacteroides / Q000187:drug effects*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; C029281:desacetylcefotaxime; D002439:Cefotaxime