title: [The pharmacological management of aggressive and autoaggressive behaviour in mentally retarded patients with melperone (author's transl)].
abstract: The results of a one year treatment with Melperone are reported. 18 mentally retarded female patients with severe aggressive and autoaggressive behaviour had been included in this open study. Six patients suffered from various epileptic seizures. A significant reduction of aggressive and autoaggressive behaviour, measured by the AFGB, was found. The activity of alkaline phosphatase showed a significant tendency towards normalisation. EEG-controls of patients with epileptic seizures showed no increase of epileptic activity in the EEG. No severe side effects were noticed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression / Q000187:drug effects*; D000469:Alkaline Phosphatase / Q000097:blood; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002090:Butyrophenones / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000523:psychology*; D007962:Leukocytes / Q000378:metabolism; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D002090:Butyrophenones; D010880:Piperidines; D000469:Alkaline Phosphatase; C008522:metylperon
vernacular_title: Die pharmakologische Beeinflussung aggressiven und autoaggressiven Verhaltens bei Geistigbehinderten mit Melperone.