Kinetics of the anti-recipient cytotoxic cell response of mice with minor histocompatibility antigen graft-vs-host disease.
The kinetics of the anti-recipient cytotoxic cell response of spleen cells from mice undergoing graft-vs-host disease (GVHD) induced to minor histocompatibility antigens were studied. Two population of cytotoxic cells were identified. Cytotoxic T lymphocytes (CTL) were present in recipient spleens 2 and 3 wk after transplantation but disappeared from the spleens before the onset of clinical disease. Cytotoxic T lymphocyte precursors (CTLp) were first detected in recipient spleens 2 wk after transplantation and were present during clinical disease. CTL may function as effectors in GVHD induced to minor histocompatibility antigens.
D000818:Animals; D000906:Antibodies; D000954:Antigens, Surface / Q000276:immunology; D002454:Cell Differentiation; D003602:Cytotoxicity, Immunologic; D005260:Female; D006087:Graft vs Host Reaction; D006648:Histocompatibility; D007700:Kinetics; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D011828:Radiation Chimera; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D018800:Thy-1 Antigens
D000906:Antibodies; D000954:Antigens, Surface; D008565:Membrane Proteins; D018800:Thy-1 Antigens