ACTH, cortisol and beta-endorphin response to metyrapone testing during chronic methadone maintenance treatment in humans.
Normal responses to metyrapone were observed in most steady-state methadone maintained treatment patients. These preliminary studies suggest that in recently detoxified methadone maintained treatment patients, there may be an exaggerated response of the hypothalamic-pituitary-adrenal axis to metyrapone.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D004723:Endorphins / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008797:Metyrapone / Q000494:pharmacology*; D019966:Substance-Related Disorders / Q000097:blood; D001615:beta-Endorphin
D004723:Endorphins; D006728:Hormones; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D008691:Methadone; D006854:Hydrocortisone; D008797:Metyrapone