Effect of indomethacin on the blood pressure and plasma catecholamine responses to acute endotoxaemia.
Injection of E. coli endotoxin (7 mg kg-1 i.v.) to pentobarbitone anaesthetized cats resulted in prolonged decrease of systemic blood pressure and increases in plasma concentrations of adrenaline, noradrenaline and 6-ketoprostaglandin (PG) F 1 alpha. Indomethacin pretreatment (10 mg kg-1 i.v.) attenuated the decrease in blood pressure following endotoxin injection. Plasma adrenaline, noradrenaline and 6-keto-PG F1 alpha were significantly lower in the indomethacin-treated cats. These data indicate that the superior haemodynamic status of the indomethacin pretreated animals exposed to endotoxic shock is not the result of potentiation of the peripheral sympathetic response.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood*; D002415:Cats; D004926:Escherichia coli; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D012772:Shock, Septic / Q000097:blood / Q000503:physiopathology*
D002395:Catecholamines; D007213:Indomethacin