Human c-fos oncogene mapped within chromosomal region 14q21----q31.
The human cellular homolog (c-fos) of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus was mapped to a single human chromosome. DNA from a series of 31 mouse-human somatic cell hybrid lines was probed with v- and c-fos molecular clones by Southern blotting. Human c-fos segregated with the distal region of the long arm of human chromosome 14. In situ hybridization of 125I-labeled human c-fos probe to normal human metaphase chromosomes independently confirmed these results and localized the c-fos oncogene to region 14q21----q31.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D003001:Cloning, Molecular; D005814:Genes, Viral; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D009053:Sarcoma Viruses, Murine / Q000235:genetics*; D014178:Translocation, Genetic