title: The pathogenesis of experimentally induced Trypanosoma brucei infection in the dog. I. Tissue and organ damage.
abstract: Inoculation of dogs with Trypanosoma brucei produced an acute fetal disease similar to that seen following natural infection. The disease was characterised by high levels of parasitaemia, moderately severe anemia, and marked changes in the lymphoid system. Extravascular invasion by large numbers of trypanosomes was widespread throughout the body and was accompanied by severe tissue damage. Tissue invasion by trypanosomes was associated with marked cellular infiltration involving lymphoid cells and plasma cells followed by macrophages and polymorphonuclear leukocytes. Associated with these reactions, severe cellular degeneration and focal necrosis occurred. While these changes were widespread and were found in the majority of tissues examined, consistently severe lesions were found in the heart, eyes and central nervous system. In many organs, lymphatic vessels were distended with fluid, trypanosomes, and a cell population similar to that in the surrounding tissue; fibrin deposition and thrombus formation was sometimes observed within the lymphatic lumens. Thrombosis was also found in the blood vessels of the pampiniform plexus, the venous plexus of the ovary, and branches of the renal vein. A severe necrotizing vasculitis affecting only the coronary vessels was a prominent feature in some animals.
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000469:parasitology / Q000473:pathology; D009202:Cardiomyopathies / Q000469:parasitology / Q000473:pathology; D003331:Coronary Vessels / Q000469:parasitology / Q000473:pathology; D004283:Dog Diseases / Q000469:parasitology / Q000473:pathology; D004285:Dogs; D004487:Edema / Q000469:parasitology / Q000473:pathology; D005128:Eye Diseases / Q000469:parasitology / Q000473:pathology; D005260:Female; D007630:Kenya; D008297:Male; D010900:Pituitary Diseases / Q000469:parasitology / Q000473:pathology; D013997:Time Factors; D014353:Trypanosomiasis, African / Q000473:pathology* / Q000662:veterinary*