Increased renal neuroleptic binding in spontaneously hypertensive rats.
The present experiments demonstrate high affinity stereospecific binding of the dopaminergic ligand [3H]spiroperidol to rat renal membranes. The binding was saturable, regionally distributed, and showed the same specificity as the caudate [3H]spiroperidol site for displacement by dopaminergic antagonists. Since there is an association between hypertension and abnormalities of renal blood flow, which appears to be regulated in part by dopamine, [3H]spiroperidol binding was measured in kidneys of spontaneously hypertensive rats. In two independent experiments renal cortical [3H]spiroperidol stereospecific binding was increased in spontaneously hypertensive rats.
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism*; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism / Q000502:physiology; D013134:Spiperone / Q000378:metabolism; D013237:Stereoisomerism; D014316:Tritium
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D014316:Tritium; D013134:Spiperone