title: Primary endocrine-secreting pancreatic tumors.
abstract: Insulinoma, glucagonoma, gastrinoma (Zollinger-Ellison syndrome), vipoma, somatostatinoma and a tumor that secretes human pancreatic polypeptide are the primary endocrine-secreting tumors of the pancreas. hormones are produced by specific tumor cell types and cause a variety of dramatic clinical pictures. Diagnosis often requires hormone assays. Computerized tomography may be helpful. Definitive surgical treatment is possible, but metastases may be present.
mesh_terms: D007516:Adenoma, Islet Cell / Q000378:metabolism*; D001079:Apudoma / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism; D015043:Zollinger-Ellison Syndrome / Q000378:metabolism
chemical_list: D005755:Gastrins; D007328:Insulin; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D005934:Glucagon