Interaction of proteins of the adenylate cyclase complex: area-limited mobility or movement along the whole membrane? Analysis with the application of the percolation theory.
Extraction of the 'fluid' lipid fraction from rat reticulocyte plasma membranes by phospholipase/BSA treatment leads to a reduction in the percentage of beta-adrenoreceptors complexed with the regulatory N-proteins and to a decrease of adenylate cyclase stimulation with a beta-agonist. Analysis of the data obtained on the basis of the percolation theory suggests that proteins of the adenylate cyclase complex move along the whole membrane.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D046911:Macromolecular Substances; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000502:physiology; D010741:Phospholipases A; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012156:Reticulocytes / Q000201:enzymology
D046911:Macromolecular Substances; D008563:Membrane Lipids; D011943:Receptors, Adrenergic, beta; D010741:Phospholipases A; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases