Effects of alleles at the W locus on testicular luteinizing hormone receptors in adult mice.
The autoregulation of testicular LH receptors was studied in Wx/Wv mice with germ cell aplasia and in normal (+/+) mice. To assess the effects of each individual allele, Wx/+ and Wv/+ mice were also examined. Basal testicular LH receptor concentration was higher in Wx/Wv mice than in all other genotypes, and higher in Wx/+ than in +/+ mice. Twenty-four h after injection of 0.3 IU hCG/g bw, LH receptor concentration was decreased in +/+ and Wv/+ mice, but not in Wx/Wv or Wx/+ animals. Administration of hCG caused a significant increase in plasma testosterone levels in all genotypes. However, injection of the highest dose of hCG used (0.9 IU/g bw) caused a significantly greater elevation in plasma testosterone in Wx/Wv than in +/+ mice. Plasma gonadotropin levels were significantly higher in Wx/Wv mice than in all other genotypes. The present results indicate that the Wx allele is responsible for the changes in testicular function observed in Wx/Wv mice, and suggest that this allele may be involved in the genetic regulation of testicular LH receptors in the mouse.
D000483:Alleles; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000097:blood; D006706:Homeostasis; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D011388:Prolactin / Q000097:blood; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D011974:Receptors, LH; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D011956:Receptors, Cell Surface; D011974:Receptors, LH; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone