Decreased beta-adrenergic responsiveness in mouse epidermal papillomas during tumor promotion with phorbol myristate acetate.
The response to the beta-adrenergic agonist (-)-isoproterenol in mouse epidermis and in papillomas arising during tumor promotion with phorbol myristate acetate was determined by measurement of cyclic AMP levels after in vivo administration of (-)-isoproterenol. Papillomas exhibited less than half the hormonal responsiveness found in epidermis from control groups or from papilloma-bearing animals. No difference in the incorporation of labelled (-)-isoproterenol into epidermal or papilloma tissue was seen.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D000242:Cyclic AMP / Q000032:analysis; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000503:physiopathology*; D010704:Phorbols; D012878:Skin Neoplasms / Q000139:chemically induced / Q000503:physiopathology*; D013755:Tetradecanoylphorbol Acetate
D000318:Adrenergic beta-Agonists; D010704:Phorbols; D000242:Cyclic AMP; D007545:Isoproterenol; D013755:Tetradecanoylphorbol Acetate