title: Strain-dependency in motor activity and in concentration and turnover of catecholamines in synchronized rats.
abstract: Circadian rhythm in motor activity was studied with an Animex motimeter in six strains of rats (ACI, BH, BS, DA, LEW, TNO) synchronized by a 12 hr light: 12 hr dark cycle. ANOVA revealed significant interstrain differences in motor activity as well as in the concentration and turnover of central noradrenaline and dopamine. Strain-dependent differences were also found with regard to tyrosine hydroxylase inhibition on motor activity. However, no significant interstrain correlations were found between endogenous concentration and/or turnover rates of the catecholamines and motor activity in normal and drug-treated rats.
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002395:Catecholamines / Q000378:metabolism*; D002940:Circadian Rhythm; D004298:Dopamine / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D009043:Motor Activity / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
chemical_list: D002395:Catecholamines; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine; D009638:Norepinephrine