Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
Women who had previously given birth to one or more infants with a neural-tube defect (NTD) were recruited into a trial of periconceptional multivitamin supplementation. 1 of 178 infants/fetuses of fully supplemented mothers (0.6%) had an NTD, compared with 13 of 260 infants/fetuses of unsupplemented mothers (5.0%).
D000022:Abortion, Spontaneous / Q000453:epidemiology; D001205:Ascorbic Acid / Q000008:administration & dosage; D001361:Avitaminosis / Q000517:prevention & control; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000453:epidemiology / Q000517:prevention & control*; D009536:Niacinamide / Q000008:administration & dosage; D011247:Pregnancy; D011446:Prospective Studies; D011736:Pyridoxine / Q000008:administration & dosage; D012256:Riboflavin / Q000008:administration & dosage; D013831:Thiamine / Q000008:administration & dosage; D014801:Vitamin A / Q000008:administration & dosage; D014807:Vitamin D / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage*
D004338:Drug Combinations; D014815:Vitamins; D014801:Vitamin A; D014807:Vitamin D; D009536:Niacinamide; D005492:Folic Acid; D011736:Pyridoxine; D001205:Ascorbic Acid; D012256:Riboflavin; D013831:Thiamine