Trophic effect of the sympathetic nervous system on vascular smooth muscle.
While the vasomotor effect of the sympathetic nervous system (SNS) on the arterial wall is well recognized, its trophic function is not. It is the aim of these studies to demonstrate this all-important function as it relates to the vascular muscle. Although the exact mechanism by which sympathetic nerve impulses influence the metabolism of the vessel wall is unknown, effects of sympathectomy can be demonstrated. Several lines of evidence indicate that chronic absence of sympathetic innervation in rabbits increases collagen synthesis and decreases activity of tricarboxylic acid cycle enzymes in the vascular wall. When chemically sympathectomized rabbits were fed a 1% cholesterol dietary supplement for 80 days, the aortas of these rabbits contained significantly more cholesterol and total lipids than those from fully innervated controls in spite of insignificant differences in plasma lipids. In a subsequent series of experiments we analyzed the efficacy of the SNS in two strains of pigeons. White Carneau (WC) pigeons are known by the susceptibility to atherosclerosis of the aorta while Show Racer (SR) pigeons are not. Our results demonstrate that the abdominal aorta of WC pigeons has less sympathetic innervation and it declines faster with age than that of SR pigeons. The results of the described studies documenting the direct trophic influence of the SNS on the arterial wall are reinforced by the similarity to the vessel wall changes induced by partial sympathectomy and natural ageing.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism; D002952:Citric Acid Cycle; D003042:Cocaine / Q000494:pharmacology; D003094:Collagen / Q000096:biosynthesis; D010856:Columbidae; D005966:Glucuronidase / Q000378:metabolism; D006892:Hydroxydopamines; D007083:Iliac Artery / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009131:Muscle, Smooth, Vascular / Q000201:enzymology / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D011817:Rabbits; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*
D006892:Hydroxydopamines; D007773:Lactates; D019344:Lactic Acid; D016627:Oxidopamine; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D005966:Glucuronidase; D000118:Acetylglucosaminidase; D003042:Cocaine; D009638:Norepinephrine