title: Sequential equilibrium gated radionuclide angiocardiography for the detection of doxorubicin cardiotoxicity.
abstract: Right and left ventricular ejection fractions (RVEF and LVEF) were studied at rest, during exercise, and in the immediate post-exercise period (recovery) in 23 patients treated with doxorubicin. Ejection fractions were determined using equilibrium gated radionuclide angiography and non-interactive computer processing. Two effects of doxorubicin emerged: (1) The LVEF at rest and the maximal LVEF reached during the stress test decreased as a function of the cumulative dose expressed in mg/m2. (2) When two measurements were performed before and after an interval dose of less than 100 mg/m2, the resting and maximal LVEF showed an increase, but at higher interval doses, those values showed a decrease. In general, the effect of an incremental dose was not a function of the cumulative dose. No significant changes were detected in RVEF, and LVEF at standardized exercise levels did not correlate with cumulative doses or change as a function of interval dosage.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000187:drug effects; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D004317:Doxorubicin; D013670:Sodium Pertechnetate Tc 99m