title: Amino acid sequence homologies between the high-mobility-group proteins, HMG-T from trout testis and HMG-1 and -2 from calf thymus: is the poly-aspartic-glutamic acid polypeptide within the main chain?
abstract: The amino acid sequence of the N-terminal two-thirds of a trout high-mobility-group protein, HMG-T, has been determined as a continuous sequence of 174 residues out of a total for the whole molecule of 260 residues. When this sequence was compared with published sequences of long cyanogen bromide-derived peptides from the analogous calf-thymus proteins, HMG-1 and -2 (Walker et al., 1979), there was strong homology, with 60-70% identity of corresponding amino acid residues in the three proteins, the majority in lengthy identical runs. However, a discrepancy in the position of a highly acidic run of aspartic and glutamic residues suggests this region may not lie within the main polypeptide chain but may represent a separate chain or possibly a branched structure.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001224:Aspartic Acid; D002417:Cattle; D002868:Chromosomal Proteins, Non-Histone; D003488:Cyanogen Bromide; D005971:Glutamates; D018698:Glutamic Acid; D006609:High Mobility Group Proteins; D008297:Male; D010455:Peptides; D013737:Testis / Q000032:analysis*; D013950:Thymus Gland / Q000032:analysis*; D014337:Trout
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D005971:Glutamates; D006609:High Mobility Group Proteins; D010455:Peptides; D001224:Aspartic Acid; D018698:Glutamic Acid; D003488:Cyanogen Bromide