Somatostatin analog: plasma catecholamine suppression mediated by the central nervous system.
The somatostatin analog, des-AA1,2,4,5,12,13-[D-Trp8]somatostatin (ODT8-SS), acts within the central nervous system to suppress the rise in plasma catecholamines associated with a variety of neural stimuli. Insulin-induced hypoglycemia or stress caused significant elevations in plasma catecholamines that were abolished by intracerebroventricular (icv) administration of ODT8-SS. Bombesin, carbachol, or 2-deoxyglucose, injected icv, evoked marked elevations in plasma epinephrine and norepineprine. These effects were also prevented by ODT8-SS given icv. In all experiments, ODT8-SS appeared to be more effective in lowering plasma epinephrine than in lowering plasma norepinephrine. Systemic administration of ODT8-SS was ineffective in lowering plasma catecholamine levels. Native somatostatin given icv produced inconsistent effects on plasma catecholamine levels. These data suggest that the somatostatin analog, ODT8-SS, acts within the central nervous system to modulate sympathetic nervous system activity. It is suggested, but not established, that this analog acts through the same receptor as native somatostatin.
D000161:Acoustic Stimulation; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001839:Bombesin / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D004837:Epinephrine / Q000097:blood*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology* / Q000031:analogs & derivatives; D013312:Stress, Physiological / Q000097:blood
D001786:Blood Glucose; D010446:Peptide Fragments; D013004:Somatostatin; C017583:somatostatin, octapeptide-Trp(8)-; D002217:Carbachol; D001839:Bombesin; D009638:Norepinephrine; D004837:Epinephrine