Failure of autoregulation and intraventricular haemorrhage in preterm infants.
Changes in mean arterial blood-pressure produced in five sick newborn infants by transfusion or exchange of blood products were accompanied by striking increases in cerebral blood-flow. These increases imply a failure of autoregulation. Four of the infants had a fatal intraventricular haemorrhage within 12 h of the observed change in flow. This suggests that the increase in flow precipitated the haemorrhage.
D001794:Blood Pressure; D001921:Brain / Q000098:blood supply*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002560:Cerebrovascular Circulation; D005078:Exchange Transfusion, Whole Blood / Q000009:adverse effects; D006706:Homeostasis; D006801:Humans; D007022:Hypotension / Q000503:physiopathology / Q000628:therapy; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D007567:Jaundice, Neonatal / Q000503:physiopathology / Q000628:therapy; D010949:Plasma; D012039:Regional Blood Flow; D012709:Serum Albumin / Q000008:administration & dosage; D065227:Transfusion Reaction
D012709:Serum Albumin