title: [Development of the progeny in prenatal fhenazepam exposure].
abstract: It was established in rat experiments that phenazepam in a dose of 100 mg/kg (1/7 LD50) per os administered during different periods of pregnancy exerts no embryotoxic or teratogenic effects recorded by means of the routine procedures applied in teratologic studies. In a dose of 10 mg/kg, however, phenazepam affects the formation of behavioral reactions in the postnatal period of ontogenesis.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D011247:Pregnancy; D051381:Rats; D013723:Teratogens; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D013723:Teratogens; D001569:Benzodiazepines; C017928:phenazepam
vernacular_title: Razvitie potomstva pri antenatal'nom vozdeistvii fenazepama.