title: [Presynaptic action of armin and galantamin on mammalian neuromuscular junction].
abstract: Actions of the two cholinesterase inhibitors: armin and galanthaamine on the neuromuscular transmission and on the spontaneous and evoked acetylcholine release were studied in the rat diaphragm. High concentrations (greater than or equal to 10(-6) g/ml) of these agents exhausted the available transmitter store which decreased the quantum content of e. p. p. sin single nerve stimulation. At the repetitive stimulation (10-100 s-1), armin and galanthaamine accelerated the presynaptic depression of e. p. p. s and slowed down the rate of transmitter mobilization. This resulted in a rapid decrease of quantum content and amplitude of e. p. p. s. The found presynaptic deteriorations together with the stationary postsynaptic depolarization may cause the neuromuscular block.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001138:Armin / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D005702:Galantamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010507:Periodicity; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D005702:Galantamine; D001138:Armin
vernacular_title: O presinapticheskom deĭstvii armina i galantamina v nervno-myshechnom soedinenii mlekopitaiushchego.