title: Bilateral diffuse malignant melanoma of the uvea associated with large cell carcinoma, giant cell type, of the lung. Case report of a newly described syndrome.
abstract: A new syndrome consisting of bilateral diffuse malignant uveal melanoma and simultaneous occurrence of another systemic malignant neoplasm was described in 6 patients in 1982. The present study reports a seventh case. Our patient was younger than the patients previously reported. He had large cell carcinoma of the right lung. The bilateral intraocular neoplasm was characterized as a diffuse malignant uveal melanoma of the mixed cell type by light microscopy and by transmission electron microscopy. All parts of the tumor contained S-100 protein. In addition to the two primary neoplasms, the patient had a combination of Ota's and Ito's naevi on the left side.
mesh_terms: D018288:Carcinoma, Small Cell / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009508:Nevus, Pigmented / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology; D013577:Syndrome; D014602:Uvea / Q000473:pathology; D014604:Uveal Neoplasms / Q000473:pathology*