4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic.
The preparation and testing of the two racemic diastereoisomers and the four optically active enantiomers of the title compound in in vitro and in vivo models for determining potential antipsychotic activity are described. Both racemic diastereoisomers and two of the four chiral enantiomers are potent and long-acting neuroleptic compounds.
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis*; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis*; D008958:Models, Molecular; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013237:Stereoisomerism; D013239:Stereotyped Behavior / Q000187:drug effects
D014150:Antipsychotic Agents; D002243:Carbolines; D007211:Indoles; D011954:Receptors, Dopamine; C026240:flutroline; D003913:Dextroamphetamine