Isolation and characterization of rat hypothalamic somatostatin-14.
A peptide with somatostatin-like immuno- and bioactivity has been isolated from 1165 rat hypothalami by using antisomatostatin affinity chromatography, gel filtration and reverse-phase high-performance liquid chromatography. The isolated peptide is indistinguishable from synthetic somatostatin-14 with respect to chromatographic properties and amino acid composition. We therefore propose that rat hypothalamic somatostatin-14 is identical in structure to somatostatin-14 found in other species.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D007031:Hypothalamus / Q000032:analysis*; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000302:isolation & purification*
D000596:Amino Acids; D013004:Somatostatin