[Impairing effect of ouabain on heart muscle slices of guinea pigs].
In heart slices of guinea pig, ouabain (10(-5) M) causes not only an inhibition of the Na+,-K+-ATPase but also damage of the cell membrane. This leads to an efflux and a degradation of the cellular NADH and NAD. By addition of these constituents to the incubation medium an increasing inhibition of the tissue respiration, caused by ouabain, is prevented.
D000818:Animals; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007700:Kinetics; D009132:Muscles / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D009243:NAD; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase
Schädigende Wirkung von Ouabain auf Herzmuskelschnitte des Meerschweinchens.