title: Somatostatin-immunoreactive fiber projections into the brain stem and the spinal cord of the rat.
abstract: By use of the PAP-immunohistochemical staining technique with serial sections, somatostatin-immunoreactive fiber projections into the brain stem and the spinal cord are described. These projections originate in the periventricular somatostatin-immunoreactive perikarya of the hypothalamus and form three main pathways: (1) along the stria medullaris thalami and the fasciculus retroflexus into the interpeduncular nucleus; (2) along the medial forebrain bundle into the mammillary body; and (3) via the periventricular gray and the bundle of Schütz into the midbrain tegmentum. Densely arranged immunoreactive fibers and/or basket-like fiber terminals are observed within the following afferent systems: somatic afferent systems (nucleus spinalis nervi trigemini, substantia gelatinosa dorsalis of the entire spinal cord), and visceral afferent systems (nucleus solitarius, regio intermediolateralis and gelatinosa gelatinosa of the sacral spinal cord). These projections form terminals around the perikarya of the second afferent neuron. Perikarya of the third afferent neuron are influenced by somatostatin-immunoreactive projections into the auditory system (nucleus dorsalis lemnisci lateralis, nucleus corporis trapezoidei). Furthermore, a somatostatin-immunoreactive fiber projection is found in the ventral part of the medial accessory olivary nucleus, in nuclei of the limbic system (nucleus habenularis medialis, nucleic supramamillaris and mamillaris lateralis) and in the formatio reticularis (nucleus Darkschewitsch, nuclei tegmenti lateralis and centralis, nucleus parabrachialis lateralis, as well as individual perikarya of the reticular formation). Targets of these projections are interneurons within interlocking neuronal chains.
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000648:ultrastructure*; D005260:Female; D007124:Immunoenzyme Techniques; D008297:Male; D009412:Nerve Fibers / Q000032:analysis* / Q000648:ultrastructure; D009434:Neural Pathways; D009475:Neurons, Afferent / Q000648:ultrastructure; D051381:Rats; D013004:Somatostatin / Q000032:analysis*; D013116:Spinal Cord / Q000648:ultrastructure*
chemical_list: D013004:Somatostatin