The effect of amygdala-kindled seizures on the acquisition of taste and odor aversions.
Two experiments were conducted to investigate the effect of amygdala-kindled seizures on the acquisition of fluid aversions using taste, odor, and compound taste-odor cues. In Experiment 1 all subjects were poisoned with lithium chloride 30 minutes after ingesting a novel taste. Experimental subjects were either kindled 15 minutes following ingestion or 15 minutes following LiCl injection. The strength of the taste aversion in the kindled animals was significantly attenuated compared to nonkindled controls. There was a tendency for kindling within the CS-US interval to be more disruptive than kindling that occurred after LiCl injection. The second study explored the effect of kindling after the CS on the development of aversions to an odor cue or a compound taste-odor cue. This study found that kindling after drinking effectively blocked the acquisition of both odor and taste aversions and compounding did not affect the strength of the odor aversion.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001245:Association Learning / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology*; D002712:Chlorides / Q000633:toxicity; D003214:Conditioning, Classical / Q000502:physiology*; D003463:Cues; D004326:Drinking; D007696:Kindling, Neurologic / Q000187:drug effects; D008094:Lithium / Q000633:toxicity; D018021:Lithium Chloride; D008297:Male; D011939:Mental Recall / Q000502:physiology; D051381:Rats; D012903:Smell / Q000502:physiology*; D013649:Taste / Q000502:physiology*
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride