Cyclic AMP as a transcriptional inhibitor of upper eukaryotic gene transcription.
Recently, glucagon and its second messenger, cyclic AMP, have been shown to stimulate the transcription rate of several upper eukaryotic genes (1-5). We show here that glucagon can also block gene transcription. Both glucagon and cyclic AMP were found to inhibit the transcription of the genes encoding three liver glycolytic enzymes, including L-type pyruvate kinase and aldolase B. Thus, cyclic AMP proves to be not only an activator but also an inhibitor of gene transcription in eukaryotes.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D006019:Glycolysis; D008099:Liver / Q000201:enzymology; D008320:Maltose / Q000494:pharmacology; D011770:Pyruvate Kinase / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects*
D004040:Dietary Carbohydrates; D012333:RNA, Messenger; D003994:Bucladesine; D008320:Maltose; D004247:DNA; D005934:Glucagon; D000242:Cyclic AMP; D011770:Pyruvate Kinase