title: Effect of angiotensin II antagonist, alpha-receptor blockage, and denervation on blood flow reduction in experimental, chronic hydronephrosis.
abstract: We studied the mechanism of elevated vascular resistance in 34 dogs with unilateral hydronephrotic kidneys. Neither an alpha-receptor blocking agent nor angiotensin II-antagonist reversed renal blood flow reduction 7 hr, 1, 2, and 3 weeks after complete unilateral ureteral ligation. We conclude that blood flow reduction is the same in the denervated hydronephrotic kidney as in the innervated obstructed kidney.
mesh_terms: D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D000818:Animals; D002908:Chronic Disease; D003714:Denervation; D004285:Dogs; D005260:Female; D006869:Hydronephrosis / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000294:innervation*; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D010627:Phenethylamines / Q000494:pharmacology*; D012039:Regional Blood Flow; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D044024:Tetralones
chemical_list: D000317:Adrenergic alpha-Antagonists; D009281:Naphthalenes; D010627:Phenethylamines; D013764:Tetrahydronaphthalenes; D044024:Tetralones; D000804:Angiotensin II; C010652:BE 2254; D015059:1-Sarcosine-8-Isoleucine Angiotensin II