title: [Catalytic properties of the monooxygenases that oxidize 14C-phenazepam].
abstract: Aromatic hydroxylation and oxidation of heterocyclic molecule of phenazepame were studied. The reaction of aromatic hydroxylation prevailed in microsomes of intact animals, whereas preinduction of rats using phenobarbital and 3-methylcholanthrene altered the phenazepame metabolism increasing the rate of oxidation in the heterocyclic ring. Kinetic parameters are described for oxidation of phenazepame molecule by both intact and induced rat microsomes.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002384:Catalysis; D004721:Endoplasmic Reticulum / Q000201:enzymology; D066298:In Vitro Techniques; D007700:Kinetics; D010084:Oxidation-Reduction / Q000187:drug effects; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002250:Carbon Radioisotopes; D001569:Benzodiazepines; C017928:phenazepam; D010105:Oxygenases
vernacular_title: Issledovanie kataliticheskikh svoĭstv monooksigenaz, okisliaiushchikh 14C-fenazepam.