title: Renal tubular acidosis associated with vitamin D-resistant rickets. Role of phosphate depletion.
abstract: 3 children with vitamin D-resistant rickets (VDRR), and severe phosphate depletion had moderate metabolitic acidosis and evidence of impaired distal tubular acidifying mechanisms. Therapy with 1-alpha-OH-vitamin D3 and phosphate supplementation improved the clinical and radiological rachitic manifestations, and resulted in the normalization of systemic acid-base parameters as well as of tubular acidification. Profound phosphate depletion is another cause of acquired, reversible distal renal tubular acidosis (RTA).
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications*; D000643:Ammonium Chloride; D002117:Calcitriol / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000150:complications*; D008297:Male; D010710:Phosphates / Q000097:blood* / Q000627:therapeutic use
chemical_list: D010710:Phosphates; D000643:Ammonium Chloride; D002117:Calcitriol