[Mechanisms of the central action of lithium].
Experiments in 486 white rats given different doses of lithium chloride into different brain structures and the abdominal cavity were examined for changes in bioelectrical brain activity, noradrenaline, adrenaline, serotonin blood content; the activity of total acetylcholinesterase. It was established that the most sensitive to lithium action is the structure of the limbic system and hypothalamus. In the mechanism of the central action of lithium of significant importance is the range of sensitivity to it of each brain structure. This sensitivity depends upon the administered dosage and chemoreactivity of the structural brain elements, conditioned by an involvement of different mediator processes, as well as by the character of intracentral interrelationships according to the principle of direct and inverse connections.
D000110:Acetylcholinesterase / Q000097:blood*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002421:Caudate Nucleus / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology; D004569:Electroencephalography; D004837:Epinephrine / Q000097:blood; D005260:Female; D008032:Limbic System / Q000187:drug effects; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D009044:Motor Cortex / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000097:blood*; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D012701:Serotonin / Q000097:blood
D002712:Chlorides; D018377:Neurotransmitter Agents; D012701:Serotonin; D008094:Lithium; D000110:Acetylcholinesterase; D018021:Lithium Chloride; D009638:Norepinephrine; D004837:Epinephrine
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