Histochemical demonstration of enhanced glutathione content in enzyme-altered islands induced by carcinogens in rat liver.
The presence of glutathione was demonstrated histochemically in livers of rats treated with diethylnitrosamine or N-nitrosomorpholine. Glutathione content was markedly elevated in adenosine triphosphatase-deficient, gamma-glutamyltranspeptidase-positive hyperplastic cell islands. This finding may partly explain the increased resistance of hyperplastic cells to cytotoxic actions of hepatocarcinogens.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D006651:Histocytochemistry; D006965:Hyperplasia / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity*; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D009602:Nitrosamines; D004052:Diethylnitrosamine; D011078:Polychlorinated Biphenyls; D005723:gamma-Glutamyltransferase; D000251:Adenosine Triphosphatases; D005978:Glutathione