Role of prostaglandins on growth hormone secretion: PGE2 a physiological stimulator.
PGE2 at 5 X 10(-8)M is a significant stimulator of GH release and seems to act at a step prior to the first signal for the inhibitory effect of SS. The amount of PGE2 released in the culture medium would appear, from what we have seen in our studies to date, to rule out any possibility that PGE2 is a GRF. However, the powerful role of PGE2 in the GH secretion process is evident. More detailed studies are needed, especially once a defined GRF becomes available. Investigations are currently in progress along these lines.
D000818:Animals; D002478:Cells, Cultured; D013006:Growth Hormone / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology
D011453:Prostaglandins; D011458:Prostaglandins E; D013004:Somatostatin; D013006:Growth Hormone; D007213:Indomethacin