Effects of glucocorticoid hormones on cell proliferation in dimethylhydrazine-induced tumours in rat colon.
Adrenocortical hormones have previously been shown to influence cell proliferation in many tissues. In this report, their influence on cell proliferation in the colonic crypt epithelium and in colonic adenocarcinomata is compared. Colonic tumour cell proliferation was found to be retarded following adrenalectomy and this retardation was reversible by administration of hydrocortisone, or by administration of synthetic steroids with predominantly glucocorticoid activity. Tumour cell proliferation in adrenalectomized rats was not promoted by the mineralocorticoid hormone aldosterone. Neither adrenalectomy, nor adrenocortical hormone treatment, significantly influenced colonic crypt cell proliferation.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D000315:Adrenalectomy; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D004127:Dimethylhydrazines; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D051381:Rats
D004127:Dimethylhydrazines; D005938:Glucocorticoids