[Relation between the nature of psychotropic effects on emotional reactivity and behavior in stress situations and the status of the brain's catecholaminergic systems].
Effects of psychotropic drugs on emotional reactivity and behavior under acute stress were studied in rats with 6-hydroxydopamine (6-HDA)-destroyed catecholaminergic brain terminals. The differences in emotional and behavioral reactivity were found in the group of animals who received 6-HDA. An abrupt reduction of tyrosine hydroxylase activity in corpus striatum of "emotional" rats correlates with noticeable difficulties in the behavior of escape out of stress and essential differences in the effects of psychotropic drugs whose action is mediated via the catecholamine neurotransmitter system.
D000661:Amphetamine / Q000627:therapeutic use; D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology*; D002395:Catecholamines / Q000502:physiology*; D003000:Clonidine / Q000627:therapeutic use; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002395:Catecholamines; D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs; D001569:Benzodiazepines; C017928:phenazepam; D000661:Amphetamine; D006220:Haloperidol; D003000:Clonidine
Izmenenie kharaktera psikhotropnogo éffekta na émotsional'nuiu reaktivnost' i povedenie v stress-situatsii v zavisimosti ot sostoianiia katekholaminergicheskikh sistem mozga.