Interaction between quercetin and superoxide radicals. Reduction of the quercetin mutagenicity.
Interaction between quercetin and superoxide radicals was investigated using xanthine-xanthine oxidase system and potassium superoxide as superoxide radical generators. Superoxide radical scavenging action of quercetin was demonstrated by measurement of the electron spin resonance spectrum of the 5-hydroperoxy-2,2-dimethyl-1-pyrrolidinyloxyl adduct. Degradation of quercetin by the radicals was demonstrated spectrophotometrically. Reduction of the quercetin mutagenicity by the radicals was demonstrated in the Salmonella typhimurium strain TA 98 by the Ames test.
D000818:Animals; D002417:Cattle; D004347:Drug Interactions; D005419:Flavonoids / Q000494:pharmacology*; D005609:Free Radicals; D009152:Mutagenicity Tests; D009153:Mutagens / Q000037:antagonists & inhibitors*; D011794:Quercetin / Q000032:analysis / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013481:Superoxides / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000378:metabolism
D005419:Flavonoids; D005609:Free Radicals; D009153:Mutagens; D013481:Superoxides; D011794:Quercetin; D014969:Xanthine Oxidase