title: Reversal by cimetidine of histamine-induced inhibition of true chemotaxis in neutrophil polymorphonuclears.
abstract: The effects of histamine and cimetidine on neutrophil locomotion were studied in vitro in experimental conditions able to dissociate random from truly directional motility. Histamine 10(-4) mol/l inhibited the true chemotactic response. Cimetidine was able to reverse the histamine-induced inhibition of true chemotaxis. Since histamine-induced inhibition of neutrophil chemotaxis may play a role in allergic patients with repeated infections, and since cimetidine has been shown to enhance cell-mediated immunity in vivo, often impaired in such cases, the use of cimetidine is suggested for the prevention of recurrences in these patients.
mesh_terms: D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D002927:Cimetidine / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects
chemical_list: D006146:Guanidines; D006635:Histamine H2 Antagonists; D002927:Cimetidine