Coronary heart disease, cancer, lipoproteins, and the effects of clofibrate: is enzyme induction a common link and are lipoproteins red herrings?
Inverse correlations between coronary heart disease (CHD) and cancer linked to circulatory levels of total and high density lipoprotein (HDL) cholesterol have been observed. This pattern (low total cholesterol/high HDL cholesterol/high cancer/low CHD) is largely mimicked by the effects of clofibrate. Clofibrate may act as an enzyme inducer and the hypothesis is that enzyme induction is responsible for this pattern. The associations between lipoproteins and both CHD and cancer may be spurious, and enzyme induction may be causally related to all the features of the pattern of correlations.
D002273:Carcinogens / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D002994:Clofibrate / Q000494:pharmacology* / Q000627:therapeutic use; D003327:Coronary Disease / Q000097:blood* / Q000517:prevention & control; D004790:Enzyme Induction / Q000187:drug effects*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008954:Models, Biological; D009369:Neoplasms / Q000097:blood* / Q000401:mortality
D002273:Carcinogens; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D002784:Cholesterol; D002994:Clofibrate