Release of cholecystokinin in response to food and intraduodenal fat in pigs, dogs and man.
The present study was done to compare endogenous cholecystokinin-33 release in response to physiologic stimuli (meal, fat) in pigs, dogs and man. Plasma levels of cholecystokinin-33 were monitored using a radioimmunoassay for cholecystokinin which detects only cholecystokinin-33 and cholecystokinin-39. Ingestion of a meal caused release of cholecystokinin-33 within five, 20 and 120 minutes in man, pigs and dogs, respectively. Intraduodenal administration of corn oil resulted in a significant release of cholecystokinin-33 within 20 minutes in dogs, pigs and man.
D000328:Adult; D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism*; D003314:Corn Oil; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005502:Food; D006801:Humans; D007441:Intubation, Gastrointestinal; D008297:Male; D009821:Oils / Q000008:administration & dosage / Q000494:pharmacology; D010446:Peptide Fragments / Q000097:blood; D011863:Radioimmunoassay; D012844:Sincalide / Q000097:blood; D013552:Swine; D013997:Time Factors
D004041:Dietary Fats; D009821:Oils; D010446:Peptide Fragments; C025997:cholecystokinin (27-33); D003314:Corn Oil; D002766:Cholecystokinin; D012844:Sincalide