[GABA-ergic effects of harman independent of its influence on benzodiazepine receptors].
It has been shown in experiments on rat cortex slices preincubated with 3H-GABA that chlorodiazepoxide (10(-6), 3.10(-5) M) does not change basal and electric stimulation-induced release of the label. It has been also shown that it does not eliminate the autoinhibitory effect of GABA on electric stimulation-induced release of 3H-GABA. However, harmane and some other (but not all) derivatives given at the same concentrations increase 3H-GABA release induced by electric stimulation and abolish the inhibitory effect of GABA without changing or slightly raising spontaneous release of 3H-GABA. It is concluded that harmane enhances the electrically stimulated release of the transmitter by GABAergic axons whatever the effect on benzodiazepine-binding areas of GABA receptors.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002707:Chlordiazepoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology
D000470:Alkaloids; D011963:Receptors, GABA-A; D006247:Harmine; D005680:gamma-Aminobutyric Acid; D002707:Chlordiazepoxide; C005010:harman
GAMK-ergicheskie éffekty garmana, nezavisimye ot vliianiia na benzodiazepinovye retseptory.