Effect of cimetidine on the gastric bacterial flora.
Bacteriological studies were carried out on samples of gastric juice obtained from 31 patients with peptic ulcer before and immediately after a month's course of cimetidine. After cimetidine there were major increases in both total bacterial counts and counts of nitrate-reducing organisms and qualitative changes suggesting the establishment of a flora which included large numbers of "faecal" organisms.
D000332:Aerobiosis; D000693:Anaerobiosis; D001419:Bacteria / Q000187:drug effects*; D002927:Cimetidine / Q000494:pharmacology*; D005243:Feces / Q000382:microbiology; D005750:Gastric Juice / Q000378:metabolism / Q000382:microbiology*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010437:Peptic Ulcer / Q000188:drug therapy; D012463:Saliva / Q000382:microbiology; D013270:Stomach / Q000382:microbiology*; D013997:Time Factors
D006146:Guanidines; D002927:Cimetidine