Successful tumour immunotherapy with cimetidine in mice.
Cimetidine significantly slowed metastatic development and prolonged survival in tumour-bearing mice, in association with inactivation of suppressor cells. Pharmacological blockade of the suppressor cell system may represent a new strategy for successful immunotherapy of human neoplasia.
D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000627:therapeutic use*; D007167:Immunotherapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D006146:Guanidines; D002927:Cimetidine