Triiodothyronine and vitamin A-deficiency in the rat.
The total (TT3) and free serum triiodothyronine (fT3) and the distribution of a tracer dose of 125I-T3 were studied in rats on a vitamin A-deficient diet. After 6 weeks on the diet there was an increased serum T3 (TT3 and fT3). But after injection of 125I-T3 a smaller radioactivity was counted in kidney and liver of deficient animals, thus revealing a smaller transport of T3 into the target cells. So vitamin A-deficiency induces an original hormonal status responsible for the conflicting metabolic changes already described in deficient rats.
D000818:Animals; D004032:Diet; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000502:physiology; D011988:Receptors, Thyroid Hormone; D014018:Tissue Distribution; D014284:Triiodothyronine / Q000097:blood / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000209:etiology / Q000378:metabolism*
D011956:Receptors, Cell Surface; D011988:Receptors, Thyroid Hormone; D014284:Triiodothyronine