Quantal transmitter release in an identified inhibitory cholinergic synapse of Aplysia.
A sustained postsynaptic potential is observed in an identified synapse of Aplysia when the presynaptic neuron is depolarized in the presence of tetrodotoxin (TTX). This prolonged postsynaptic potential appears to be at least in part due to the summation of quantal events. It is still observed when 30 mM CoCl2, which is known to inhibit Ca2+ influx, is added to the external media.
D000109:Acetylcholine / Q000378:metabolism*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001048:Aplysia; D002118:Calcium / Q000502:physiology; D003035:Cobalt / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology*; D013570:Synaptic Membranes / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology
D003035:Cobalt; D013779:Tetrodotoxin; D000109:Acetylcholine; D002118:Calcium