[Desensitization of beta-adrenoreceptors and its influence on manifestations of the antiradiation effect of isoproterenol].
A study was made of the function of beta-adrenoreceptors and Chinese hamster fibroblast cAMP during their desensitization to isoproterenol. Desensitization of adenylate cyclase was demonstrated to lead to the reduction of both the cAMP response to isoproterenol and isoproterenol capacity to protect the cells from ionizing radiation. This did not entail any changes in the number of beta-adrenoreceptors or in the dissociation constant of the beta-antagonist. It is assumed that desensitization provokes functional dissociation of the beta-receptor and adenylate cyclase. Intact adenylate cyclase is an absolute must for realization of the antiradiation potency of isoproterenol.
D000262:Adenylyl Cyclases / Q000528:radiation effects; D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D000242:Cyclic AMP / Q000528:radiation effects; D004082:Dihydroalprenolol / Q000494:pharmacology; D004361:Drug Tolerance; D007545:Isoproterenol / Q000494:pharmacology*; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors
D011837:Radiation-Protective Agents; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol
Desensibilizatsiia beta-adrenoretseptorov i ee vliianie na proiavlenie protivoluchevogo éffekta izoproterenola.