[Fundamental and clinical studies on sulbactam/cefoperazone in the field of obstetrics and gynecology].
The tissue penetration of sulbactam/cefoperazone (SBT/CPZ) was studied. The drug was also used in the treatment of 3 patients with gyneco-obstetrical infection. The results of these studies are summarized as follows. The elbow venous blood concentration and uterine arterial blood concentration were in about the same level and diminution curve of their concentrations took also a similar pattern. The tissue levels of the uterus and uterine appendices were determined and found to be high in the portio vaginalis, myometrium and oviduct. Each of the 3 patients with whom the dead space fluid concentration was determined showed her own concentration curve. SBT/CPZ was administered to 2 patients with adnexitis and 1 patient with pelvic peritonitis, and was markedly effective in 2 patients and moderately effective in other 1 patient.
D000290:Adnexa Uteri / Q000378:metabolism; D000328:Adult; D002438:Cefoperazone / Q000008:administration & dosage / Q000378:metabolism*; D004338:Drug Combinations; D004341:Drug Evaluation; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy*; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000378:metabolism*; D010538:Peritonitis / Q000188:drug therapy*; D013407:Sulbactam; D014599:Uterus / Q000378:metabolism; D065093:beta-Lactamase Inhibitors
D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; D002438:Cefoperazone; D010397:Penicillanic Acid; D013407:Sulbactam