Mutagenic urine in cirrhosis.
Multiple samples of daytime urine from 5 non-smoking patients with cirrhosis, 12 healthy smokers, and 15 healthy non-smokers were collected and analysed for mutagens by the Ames salmonella microsome assay. All 12 samples collected from the 5 cirrhotic patients were mutagenic. 16 of the 17 samples collected from the smokers were mutagenic, while only 2 of the 24 samples from the non-smokers were mutagenic. The discovery of mutagens in the urine of non-smoking patients with cirrhosis is new.
D001437:Bacteriuria / Q000652:urine; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics / Q000382:microbiology / Q000652:urine*; D008861:Microsomes; D009153:Mutagens / Q000302:isolation & purification*; D009154:Mutation; D012475:Salmonella / Q000235:genetics; D012907:Smoking / Q000150:complications*
D009153:Mutagens