[Influence of calcitonin and ACTH 4-10 on the phenomena of mammary tumor induction by a chemical carcinogen, 7,12-dimethylbenzanthracene].
We have studied the effects of a single intravenous injection of calcitonin (TCT) and ACTH 4-10 on the induction of mammary tumors by Dimethylbenz(a)anthracene (DMBA) in Sprague Dawley female rats. In the animals which received TCT, we observed a significant delay in the occurrence of tumors, and a decrease in their number and size. Administration of ACTH 4-10 gave similar results. The inhibitory effect of TCT on tumoral induction and growth can be explained by the hypocalcemic action of TCT. Conversely, ACTH 4-10 having no effect on calcemia, the mechanism of action of this peptide on tumoral induction remains to be elucidated.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology* / Q000502:physiology; D002118:Calcium / Q000097:blood; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010446:Peptide Fragments; D015127:9,10-Dimethyl-1,2-benzanthracene; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D002116:Calcitonin; C011394:ACTH (4-10); D002118:Calcium
Influence de la calcitonine et de l'ACTH 4-10 sur les phénomènes d'induction tumorale mammaire induits par un carcinogène chimique, le 7-12 diméthylbenz(a)anthracène.