title: [Reduction of regurgitation in aortic insufficiency by inhibition of the renin-angiotensin converting enzyme].
abstract: The effect of captopril-mediated afterload reduction on regurgitation was investigated in 10 patients with aortic insufficiency. Regurgitation was quantitated by the regurgitation fraction and the relation of regurgitant volume to enddiastolic volume, which were derived from gated radionuclide ventriculography. 19 patients with coronary artery disease and no evidence of valvular heart disease served as controls. In patients with coronary artery disease no significant regurgitation was found. In patients with aortic regurgitation the blood concentration of angiotensin I increased whereas that of angiotensin II decreased significantly after captopril-medication; thus, the conversion of angiotensin I to II was reduced to about 50% of the control value. Whereas blood pressure and heart rate did not change significantly, the regurgitation fraction and the normalized regurgitant volume were significantly reduced. The ejection fraction remained essentially unchanged. These findings suggest a favorable influence of captopril-induced afterload reduction on hemodynamics in aortic regurgitation.
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002216:Captopril / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D011392:Proline / Q000031:analogs & derivatives*; D011877:Radionuclide Imaging; D013667:Technetium
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D013667:Technetium; D011392:Proline; D002216:Captopril
vernacular_title: Reduktion der Regurgitation bei Aorteninsuffizienz durch Hemmung des Renin-Angiotensin-Konversionsenzyms.