title: An open comparison between free and a fixed combination of diuretic and beta-blocker in the management of essential hypertension.
abstract: A total of 1,117 patients with inadequately controlled hypertension in spite of treatment with a combination of diuretic and beta-adrenergic blocker were studied. Treatment was changed to one or two tablets daily of Trasidrex (160 mg oxprenolol hydrochloride in a sustained release formulation and 0.25 mg cyclopenthiazide) with a subsequent improvement, 4 weeks later, in blood pressure control. Side-effects of treatment were uncommon and treatment was approved by the majority of patients. The majority of doctors participating thought a fixed combination would improve patient compliance with therapy.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D003518:Cyclopenthiazide / Q000008:administration & dosage / Q000009:adverse effects; D004232:Diuretics; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010096:Oxprenolol / Q000008:administration & dosage / Q000009:adverse effects; D010349:Patient Compliance; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage*; D013607:Tablets
chemical_list: D000319:Adrenergic beta-Antagonists; D004232:Diuretics; D004338:Drug Combinations; D049993:Sodium Chloride Symporter Inhibitors; D013607:Tablets; D010096:Oxprenolol; D003518:Cyclopenthiazide