title: The use of antihistamine to retard the growth of fibroblasts derived from human skin, scar, and keloid.
abstract: Sixty percent of the fibroblast strains derived from normal skin, scar, and keloid reached elevated growth plateaus when cultured in the presence of histamine. A pharmacologic level of the antihistamine diphenhydramine hydrochloride was able to suppress the stimulation in all the keloid strains that were histamine-sensitive.
mesh_terms: D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D007627:Keloid / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000166:cytology*
chemical_list: D006634:Histamine H1 Antagonists