[Effect of the acetyl derivatives of 4,5,6,7-tetrahydroindole on the enterochromaffin cells and mediator metabolism of the rat brain].
It was reported previously that the analogues of dimecabin (1,2-dimethyl-3-carbethoxy-5-oxyindole),2-methyl-3-carbethoxy-5-oxyindole and the derivatives of 2-methyl-3-carbethoxy-4, 5, 6, 7-tetrahydroindole substituted in the 1st position reduce the content of argentaffinic substance in enterochromaffin cells (EC) for a long period of time. It has been shown that "recognizability" of the acetyl derivatives of 4, 5, 6, 7-tetrahydroindole by the EC receptor systems is preserved. Administration of the acetyl derivatives into the stomach (10 mg/kg for 5 days) induce a prolonged decrease in the argentaffin substance content in EC, and augment the noradrenaline level without exerting a pronounced effect on the dopamine content. These substances also inhibit monoamine oxidase and acetylcholinesterase activity in the rat brain. Detection in EC of the biologically active substances common to the APUD-system and the brain suggests a new trend in the study into the action mode of indole compounds.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002838:Chromaffin System / Q000187:drug effects*; D004759:Enterochromaffin Cells / Q000187:drug effects*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D007211:Indoles; D018377:Neurotransmitter Agents
Vliianie atsetil'nykh proivzodnykh 4,5,6,7-tetragidroindola na énterokhromaffinnye kletke i mediatornyĭ obmen mozga krys.