Effects of CS-386 and diazepam upon the gastric contraction and excitation of lumbar gamma-motoneurons following stimulation of the hypothalamus in the cat.
Effects of a new minor tranquilizer, CS-386 and diazepam were studied upon the gastric contraction and excitation of lumbar gamma-motoneurons following stimulation of some of the brain structures as well as upon the spontaneous gastric motility in the cat. CS-386 inhibited the hypothalamus-induced gastric contraction with little changes in spontaneous motility at doses of 5 and 10 mg/kg (i.d.). Diazepam inhibited both the hypothalamus-induced contraction and spontaneous motility at these doses. The vagal nerve-induced gastric contraction was suppressed by diazepam (5 mg/kg, i.d.) but not by the same dose of CS-386. Bemegride (5 mg/kg, i.v.) antagonized almost completely the depression caused by 5 mg/kg of CS-386, but not that by a dose of 10 mg/kg or 5 as well as 10 mg/kg of diazepam. Excitation of the lumbar gamma-motoneuron following stimulation of the posterior hypothalamus or the mesencephalic reticular formation was depressed by CS-386 or diazepam (10 mg/kg, p.o.), but not by lower doses. Based on the these evidences, it was suggested that CS-386 could be effective in stress-induced gastric lesions with lower side effects in digestive organs than diazepam.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D002415:Cats; D003975:Diazepam / Q000494:pharmacology*; D004558:Electric Stimulation; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D008161:Lumbosacral Region; D008297:Male; D009046:Motor Neurons / Q000187:drug effects*; D009047:Motor Neurons, Gamma / Q000187:drug effects*; D010080:Oxazoles / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D010080:Oxazoles; D001569:Benzodiazepines; D003975:Diazepam; C014262:mexazolam