Pharmacological reactivity of granulation tissue.
The contractile system of the myofibroblast has well defined characteristics. The findings suggest the presence of 5-hydroxytryptaminergic as well as alpha and beta-adreno-receptors, although both appear to be immature. It does not have cholinergic or histaminergic receptors. The contractile system is inhibited by cytochalasin B and is not sensitive to colchicine. The contractile machinery is suggested to be the microfilament system, as it occurs in the contractile apparatus of primitive cells. This is in accordance with the role of myofibroblasts in granulation tissue neoformation.
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D006097:Granulation Tissue / Q000187:drug effects*; D006632:Histamine / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000502:physiology; D010455:Peptides / Q000502:physiology; D011453:Prostaglandins / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
D002121:Calcium Channel Blockers; D010455:Peptides; D011453:Prostaglandins; D012701:Serotonin; D003571:Cytochalasin B; D006632:Histamine; D003078:Colchicine