[Influence of the procedure of administration in the activity of some antidepressant or disinhibiting drugs upon behavioural despair (author's transl)].
Imipramine, doxepin, mianserin, pipotiazine and sulpiride, all active upon behavioural despair test of Porsolt and coll. in unique administration, are devoid of activity, with the exception of mianserin and sulpiride, in repetitive administration. It would be possible that a diminution of cerebral levels of neurotransmitters NA and DA after repetitive administration of imipramine, doxepin and pipotiazine (or an over-sensitivity to serotonin in the case of imipramine and doxepin) and an increase of these levels after repetitive administration of mianserin and sulpiride (with an antiserotonin activity for mianserin) would be responsible for these discrepancies.
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D000928:Antidepressive Agents; D014150:Antipsychotic Agents
Influence du mode d'administration sur l'action de quelques antidépresseurs et neuroleptiques désinhibiteurs sur le comportement de désespoir.