title: Acute liver disease associated with sodium valproate.
abstract: Five patients, four of them children, had acute liver disease after treatment with sodium valproate. Three died. The liver disease began 3-6 months after the start of treatment and was often associated with other side-effects of sodium valproate such as thrombocytopenia and hair loss.
mesh_terms: D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy; D005234:Fatty Liver / Q000139:chemically induced; D005260:Female; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D008297:Male; D009336:Necrosis; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D014635:Valproic Acid