Reduced kainic acid binding in rat hippocampal formation after limbic kindling.
The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less than in electrode-implanted unstimulated controls. Specific binding in the inner third of the dentate molecular layer was reduced to a lesser degree. These observations demonstrate that kainic acid receptors are down-regulated by kindling stimulation.
D000679:Amygdala / Q000502:physiology; D000818:Animals; D001345:Autoradiography; D004558:Electric Stimulation; D006624:Hippocampus / Q000378:metabolism*; D007608:Kainic Acid / Q000378:metabolism*; D007696:Kindling, Neurologic; D008032:Limbic System / Q000502:physiology*; D008297:Male; D011759:Pyrrolidines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D007608:Kainic Acid; D011759:Pyrrolidines; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter