[Changes in benzodiazepine receptors in the limbic system following kindling of the olfactory bulb in rats].
Repeated electrical stimulations of the olfactory bulb led to the progressive development of a generalized epilepsy (kindling effect). One week after the last stimulation eliciting a stage 5 seizure, diazepam-(3H) binding was studied in olfactory bulb-kindled rats. Numbers of benzodiazepine receptors were increased in kindled olfactory bulb and amygdala. No significant change was observed in hippocampus. This modification could be considered as a response of the inhibitory mechanisms to repeated seizures which is insufficient to counteract the installation of the kindling effect.
D000818:Animals; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004827:Epilepsy / Q000378:metabolism*; D007696:Kindling, Neurologic; D008032:Limbic System / Q000378:metabolism*; D009830:Olfactory Bulb / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism* / Q000502:physiology
D011963:Receptors, GABA-A
Modifications dans le système limbique des récepteurs aux benzodiazépines après embrasement du bulbe olfactif chez le rat.