Isolation and characterization of I5B2, a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp.
A new inhibitor of angiotensin I converting enzyme, I5B2, was isolated from the culture broth of Actinomadura sp. No. 937ZE-1. This compound contains N-methylvaline, tyrosine and 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid. The microorganism also produced another inhibitor, I5B1, which is identical with K-4 isolated from Actinomadura sp. as an antihypertensive agent.
D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides / Q000302:isolation & purification*; D009618:Nocardiaceae / Q000378:metabolism*; D063065:Organophosphonates / Q000032:analysis; D010748:Phosphopeptides
D000806:Angiotensin-Converting Enzyme Inhibitors; D004151:Dipeptides; D063065:Organophosphonates; D010748:Phosphopeptides; C048655:antibiotic K 4; C043471:I5B2