Effect of sulphated polysaccharides on the alpha 1-antitrypsin inhibition of amidolysis catalysed by coagulation cascade proteinases.
1 The ability of several sulphated polysaccharide anticoagulants to prevent alpha 1-antitrypsin inhibition of thrombin paralleled their ability to potentiate antithrombin III inhibition of thrombin. None of the compounds examined altered the ability of alpha 1-antitrypsin to inhibit activated coagulation factor X (Xa). 2 These results are consistent with the possibility that a direct polysaccharide-proteinase interaction may be involved in the sulphated polysaccharide-modulated inhibition of thrombin by antithrombin III.
D000577:Amides / Q000378:metabolism*; D001777:Blood Coagulation; D004347:Drug Interactions; D010450:Endopeptidases / Q000378:metabolism*; D005170:Factor X / Q000037:antagonists & inhibitors; D006801:Humans; D011134:Polysaccharides / Q000494:pharmacology*; D013464:Sulfuric Acids / Q000494:pharmacology; D013917:Thrombin / Q000037:antagonists & inhibitors; D000515:alpha 1-Antitrypsin / Q000494:pharmacology*
D000577:Amides; D011134:Polysaccharides; D013464:Sulfuric Acids; D000515:alpha 1-Antitrypsin; D005170:Factor X; D010450:Endopeptidases; D013917:Thrombin