title: Neuroleptic 4-aryltetrahydropyrrolo[3,4-b]indoles.
abstract: 7-Fluoro-4-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole displayed neuroleptic-like activity in an animal model approximately equipotent with that of chlorpromazine but was of substantially greater duration of action. Structure-activity relationships of the series are discussed.
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis*; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D014150:Antipsychotic Agents; D007211:Indoles; D011758:Pyrroles; D003913:Dextroamphetamine