Effects of prolyl hydroxylase inhibition on arterial collagen synthesis and blood pressure in hypertensive rats.
Changes in arterial collagen synthesis and the effects of P-1894B, a potent inhibitor of prolyl hydroxylase, were investigated on rat hypertension, induced by deoxycorticosterone acetate (DOCA) and salt. In DOCA-salt hypertensive rats, prolyl hydroxylase activity increased significantly in the abdominal aorta and in the mesenteric artery. Incorporation of 14C-proline into the thoracic aorta, abdominal aorta and mesenteric artery was higher and the hydroxyproline content of the abdominal aorta and mesenteric artery was higher than in the control rats. Treatment with P-1894B significantly inhibited prolyl hydroxylase activity, reduced arterial collagen synthesis, but did not prevent or reverse hypertension.
D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology; D001158:Arteries / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D003094:Collagen / Q000096:biosynthesis*; D003900:Desoxycorticosterone / Q000494:pharmacology; D006909:Hydroxyproline / Q000378:metabolism; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors*; D011392:Proline / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY
D000880:Anthraquinones; D003900:Desoxycorticosterone; C032958:vineomycin A1; D003094:Collagen; D011392:Proline; D011393:Procollagen-Proline Dioxygenase; D006909:Hydroxyproline