Effect of colchicine on rat liver plasma membrane.
Colchicine effect has been tested on rat liver plasma membrane-bound enzymes after in vitro or in vivo treatment. It appears that the in vitro treatment does not affect 5'-nucleotidase, Mg2+-ATPase and (Na+ + K+)-ATPase, whereas adenylate cyclase is sensitive to both in vitro and in vivo treatment, the latter condition being also effective for 5'-nucleotidase.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology*; D003078:Colchicine / Q000494:pharmacology*; D005934:Glucagon / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008162:Lumicolchicines / Q000494:pharmacology; D008297:Male; D009708:Nucleotidases / Q000378:metabolism; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013050:Spectrometry, Fluorescence
D008162:Lumicolchicines; D005934:Glucagon; D009708:Nucleotidases; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000262:Adenylyl Cyclases; D000254:Sodium-Potassium-Exchanging ATPase; D003078:Colchicine