title: Physiological role of peroxisomal beta-oxidation in liver of fasted rats.
abstract: In the livers of fasted rats, the activity of peroxisomal palmitocyl-CoA oxidation (NADH production) was increased more rapidly and markedly than that of mitochondrial carnitine palmitoyltransferase, which is the rate limiting enzyme of mitochondrial beta-oxidation. The peroxisomal oxidizing activity was about twice that of the control throughout the period of fasting (1-7 days). carnitine acetyltransferase activity was increased to a similar extent in both peroxisomes and mitochondria. A possible physiological role of liver peroxisomes may thus be as an effective supply of NADH2, acetyl residues and short and medium-length fatty acyl-CoA in the cells on the enhancement of peroxisomal beta-oxidation of the animals under starvation; these substances thus produced may be transported into the mitochondria as energy sources.
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D003486:Cyanides / Q000494:pharmacology; D003605:D-Amino-Acid Oxidase / Q000378:metabolism; D005215:Fasting; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D008830:Microbodies / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000201:enzymology; D009940:Organoids / Q000378:metabolism*; D010084:Oxidation-Reduction; D010171:Palmitoyl Coenzyme A / Q000378:metabolism*; D051381:Rats; D014503:Urate Oxidase / Q000378:metabolism
chemical_list: D000214:Acyl Coenzyme A; D003486:Cyanides; D010171:Palmitoyl Coenzyme A; D002374:Catalase; D003605:D-Amino-Acid Oxidase; D014503:Urate Oxidase; D002334:Carnitine O-Palmitoyltransferase; D002332:Carnitine O-Acetyltransferase