Effect of chronic beta-adrenergic therapy on the human lymphocyte response to concanavalin A.
Lymphocytes isolated from cystic fibrosis patients chronically treated with beta-adrenergic agonists respond significantly differently to epinephrine modulation of mitogen challenge than either cystic fibrosis patients not receiving beta-adrenergic therapy or normal human volunteers. Those patients on chronic beta-adrenergic therapy are insensitive to the modulating effects of 1-epinephrine. This observation is discussed in terms of adrenergic receptor alteration and/or different cystic fibrosis disease states.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D003208:Concanavalin A / Q000494:pharmacology*; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D003208:Concanavalin A