Changes of [3H]spiroperidol binding in the renal artery of aged rabbits.
Using mature (12 months), old (70 months) rabbits and 3H-labeled spiroperidol, the characteristics of renal artery dopamine receptors were studied. In old age the dissociation constant of [3H]spiroperidol was unchanged, while maximum specific binding was reduced more than 45%. The present data seem to indicate an impairment of peripheral dopaminergic function in ageing.
D000375:Aging; D000818:Animals; D002090:Butyrophenones / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D008297:Male; D011817:Rabbits; D011954:Receptors, Dopamine / Q000378:metabolism / Q000502:physiology; D012077:Renal Artery / Q000378:metabolism* / Q000502:physiology; D013134:Spiperone / Q000378:metabolism*
D002090:Butyrophenones; D011954:Receptors, Dopamine; D013134:Spiperone; D000242:Cyclic AMP; D004298:Dopamine