Renin-angiotensin activation is not primarily responsible for the changes in mean arterial pressure during sternotomy in patients undergoing cardiac surgery.
The effect of the administration of a 50 mg dose of an angiotensin converting enzyme inhibitor (captopril) on the mean arterial pressure following sternotomy in 13 patients undergoing coronary artery bypass surgery was indistinguishable from the response in 13 patients who had not received the drug.
D000328:Adult; D000368:Aged; D000758:Anesthesia; D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010101:Oxygen Consumption; D011392:Proline / Q000031:analogs & derivatives*; D012084:Renin-Angiotensin System; D013249:Sternum / Q000601:surgery*
D000806:Angiotensin-Converting Enzyme Inhibitors; D011392:Proline; D002216:Captopril