title: Simian virus 40 replication pause sites map with the nucleosomes.
abstract: The locations of replication pause sites in the simian virus 40 minichromosome which were determined by sizing cloned fragments of nascent DNA (Zannis-Hadjopoulos et al., J. Mol. Biol. 165:599-607, 1983) were compared with the positions of simian virus 40 nucleosomes in the genome, as obtained by sequence-directed mapping (G. Mengeritsky and E. N. Trifonov, Nucleic Acids Res. 11:3833-3851, 1983; Mengeritsky and Trifonov, Cell Biophys. 6:1-8, 1984). Clear correlation between these two maps is demonstrated, suggesting that nucleosomes hinder propagation of the replication forks.
mesh_terms: D004261:DNA Replication; D007700:Kinetics; D009707:Nucleosomes / Q000502:physiology* / Q000648:ultrastructure; D013539:Simian virus 40 / Q000235:genetics*; D014779:Virus Replication
chemical_list: D009707:Nucleosomes