[Clinical relevance of pharmacokinetic differences in benzodiazepines].
The pharmacokinetics of benzodiazepines have gained increasing importance since clinical findings indicate differences in profiles of clinical action and abuse potential between members of this class of compounds which cannot be explained by differences in molecular structure but correlate closely with specific features of invasion and elimination kinetics. This correlation is discussed on data from the literature and demonstrated by means of computer simulated plasma level curves.
D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D001569:Benzodiazepines; D001682:Biological Availability; D004334:Drug Administration Schedule; D006207:Half-Life; D006801:Humans; D008657:Metabolic Clearance Rate; D011955:Receptors, Drug / Q000378:metabolism; D011963:Receptors, GABA-A; D019966:Substance-Related Disorders / Q000209:etiology
D014151:Anti-Anxiety Agents; D011955:Receptors, Drug; D011963:Receptors, GABA-A; D001569:Benzodiazepines
Zur klinischen Relevanz pharmakokinetischer Unterschiede bei Benzodiazepinen.