title: [The effect of bromazepam on fitness to drive (author's transl)].
abstract: On 3 days (1, 8, 15) the acute (on day 1) and subacute (days 8 und 15) effects of bromazepam (Lexotanil) on variables of driving ability were studied in 55 young male medical students, randomly divided into 3 groups (placebo, 1.5 mg, 3.0 mg). The drug was well tolerated (no notable side effects). Dose-effects showed trends in group 3 (3.0 mg) with a stronger subjective impression of performance impairment which was, however, not confirmed by objective performance assessment, although time of reaction to optical stimuli was significantly longer after the 3 mg dose. In the discussion, it is pointed out that the results of this type of study in healthy subjects can only be regarded as indicative.
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001334:Automobile Driving; D001364:Awareness / Q000187:drug effects; D001960:Bromazepam / Q000009:adverse effects*; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects
chemical_list: D014151:Anti-Anxiety Agents; D001960:Bromazepam
vernacular_title: Die Wirkung von Bromazepam auf die Fahrtüchtigkeit.