Synaptic proteins after electroconvulsive seizures in immature rats.
The forebrain content of several rat brain synaptic proteins (synaptin, D1, D2, and D3) was reduced in rats receiving electroconvulsive seizures on days 2-11, 9-18, or 19-28 and sacrificed at the age of 30 days. Forebrain weight, total protein, and the glial enzyme glutamine synthetase were also decreased, whereas the neuronal enolase 14-3-2 was unchanged. The findings suggest that seizures in the immature rat brain resulted in a parallel reduction of synaptic material and of the amount of glial cells. The increased concentration of the enolase 14-3-2 found in rats seizured on days 19-28 may reflect the high demands on the glycolytic system during the seizures.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004597:Electroshock; D005260:Female; D005974:Glutamate-Ammonia Ligase; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009929:Organ Size; D051381:Rats
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C023513:brain-specific protein D2, rat; C028116:nervous system specific protein D1; C028117:nervous tissue specific protein D3; C030625:synaptin; D005974:Glutamate-Ammonia Ligase