title: [Beta-endorphin concentration in the cerebrospinal fluid of schizophrenics].
abstract: beta-endorphin concentration in cerebrospinal fluid (CSF) in 21 schizophrenic and 15 neurological patients was determined by radioimmune assay. On the basis of the obtained data a correlation between the change of beta-endorphin level in CSF of schizophrenics and that of the clinical state of these patients was assumed as a result of a short-term discontinuance of the treatment. It was established that the reduction of beta-endorphin level in CSF of schizophrenics correlates with the intensification of hallucinatory-delusional disorders.
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage; D004723:Endorphins / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D012563:Schizophrenia, Paranoid / Q000134:cerebrospinal fluid; D001615:beta-Endorphin
chemical_list: D014150:Antipsychotic Agents; D004723:Endorphins; D001615:beta-Endorphin
vernacular_title: Soderzhanie beta-éndorfina v likvore bol'nykh shizofrenieĭ.