[Psychomotor excitation caused by beta-endorphin: effect of rubidium and lithium].
Effects of lithium and rubidium administered into the cerebral ventricles of conscious cats on psychomotor excitation produced by synthetic human beta-endorphin similarly injected have been investigated. Lithium, but not rubidium, prevented the psychomotor stimulation caused by beta-endorphin. Naloxone, applied intracerebroventricularly, also prevented the psychomotor stimulation produced by this polypeptide. It appears, therefore, that only lithium has a psychotherapeutic value when homeostatic neurohumoral mechanisms are disturbed in the central nervous system by a surplus of beta-endorphin.
D017109:Akathisia, Drug-Induced; D000818:Animals; D002415:Cats; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D012413:Rubidium / Q000008:administration & dosage / Q000494:pharmacology*; D001615:beta-Endorphin
D004723:Endorphins; D009270:Naloxone; D001615:beta-Endorphin; D008094:Lithium; D012413:Rubidium
Excitation psychomotrice causée par la beta-endorphine: les effets du rubidium et du lithium.