Physiological mechanism by which acetyl CoA carboxylase is regulated.
Compared with rats fed a normal diet, the activity of the protein inhibitor of acetyl CoA carboxylase in rat liver doubled after 48 h of fasting. Conversely, acetyl CoA carboxylase activity was diminished by nearly one half. In animals fasted and then subsequently refed a fat free diet, acetyl CoA carboxylase activity was elevated by nearly 9-fold, with a concomitant decrease in the activity of the protein inhibitor by about 9-fold as compared to fasted rats. Hence it appears that the regulatory protein inhibitor for acetyl CoA carboxylase is of physiological significance for fatty acid biosynthesis.
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D005215:Fasting; D005227:Fatty Acids / Q000096:biosynthesis; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats
D004041:Dietary Fats; D005227:Fatty Acids; D008025:Ligases; D000103:Acetyl-CoA Carboxylase