Effect of neurotensin on gastric function in man.
Neurotensin is a peptide recently discovered in the human ileum and it is released into plasma after ingestion of food. Neurotensin was infused intravenously into 12 healthy volunteers at a mean dose of 2.4 pmol/kg/min, the mean rise in plasma levels being 89 +/- 8 pmol/l. An inhibition of both gastric acid and pepsin output, and also a delay in gastric emptying of oral glucose, were observed. Neurotensin may therefore have a physiological role in modulating gastric function in man.
D000328:Adult; D000818:Animals; D002417:Cattle; D003864:Depression, Chemical; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D006727:Hormone Antagonists; D006728:Hormones / Q000008:administration & dosage; D006801:Humans; D007082:Ileum / Q000378:metabolism; D007263:Infusions, Parenteral; D008297:Male; D009496:Neurotensin / Q000008:administration & dosage / Q000502:physiology*; D010418:Pentagastrin / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D010434:Pepsin A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013268:Stimulation, Chemical
D006727:Hormone Antagonists; D006728:Hormones; D009496:Neurotensin; D010434:Pepsin A; D010418:Pentagastrin