[Mechanism of action of digitalis glycosides].
It appears well established that the inotropic effect of digitalis is due initially to inhibition of the sodium pump (Na-K-ATPase), initiating a cascade effect which in turn increases "diastolic" intracellular Ca2+, which then increases "systolic" intracellular Ca2+ responsible for the inotropic effect.
D002118:Calcium / Q000378:metabolism; D004071:Digitalis Glycosides / Q000494:pharmacology*; D006801:Humans; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D004071:Digitalis Glycosides; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium
Mécanisme d'action des digitaliques.