Inhibition of platelet phosphatidylinositol synthetase by an analog of CDP-diacylglycerol.
Unpublished portions of the synthesis of a phosphinate-phosphonate diether analog of CDPdiacylglycerol are reported. The liponucleotide analog was found to be a very powerful inhibitor of platelet PI synthetase; kinetic data suggest a competitive inhibition mechanism. The structural specificity of CDPdiacylglycerol for liponucleotide-mediated biosynthetic reactions is discussed.
D001792:Blood Platelets / Q000201:enzymology*; D051607:CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase; D003567:Cytidine Diphosphate Diglycerides / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008565:Membrane Proteins; D009702:Nucleoside Diphosphate Sugars / Q000494:pharmacology*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors / Q000097:blood*; D013055:Spectrophotometry, Infrared; D017855:Transferases (Other Substituted Phosphate Groups)
D003567:Cytidine Diphosphate Diglycerides; D007202:Indicators and Reagents; D008565:Membrane Proteins; D009702:Nucleoside Diphosphate Sugars; C043487:cytidine S-3,4-dioctadecoxybutylphosphinato(methylene phosphonate); D010770:Phosphotransferases; D017855:Transferases (Other Substituted Phosphate Groups); C496766:CDIPT protein, human; D051607:CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase