The effect of anion channel blockers on enzymatic activity of Na+/K+-ATPase and the electrogenic Na+/K+ pump.
Disulfonic stilbenes which block the anion-transport in red blood cells were found to inhibit the brain microsomal Na+/K+-ATPase but not the electrogenic Na+/K+ pump in intact muscle cells. In contrast to the anion-transport system, the Na+/K+-ATPase is inhibited by disulfonic stilbenes, apparently from the cytoplasmic side of the membrane. The pathways for anion and active cation transport are thus different but similar groups of sulfhydryl and/or amino acid residues must play an important role in both systems.
D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology; D007425:Intracellular Membranes / Q000201:enzymology; D007700:Kinetics; D008564:Membrane Potentials; D008861:Microsomes / Q000201:enzymology; D009132:Muscles / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013267:Stilbenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D013267:Stilbenes; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium