Synthesis and biological evaluation of p-bromospiperone as potential neuroleptic drug.
p-Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001667:Binding, Competitive; D002090:Butyrophenones / Q000138:chemical synthesis*; D002417:Cattle; D002421:Caudate Nucleus / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011388:Prolactin / Q000097:blood; D011954:Receptors, Dopamine / Q000187:drug effects; D013134:Spiperone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D014150:Antipsychotic Agents; D002090:Butyrophenones; D011954:Receptors, Dopamine; D013134:Spiperone; C026326:4-bromospiperone; D011388:Prolactin