Rotavirus in pediatric diarrhoea at Siriraj Hospital, Bangkok, Thailand.
Between June 1982 and May 1983, rotavirus was found in 29% of 248 pediatric patients between 1 month to 5 years of age at Siriraj Hospital, Bangkok, Thailand. Among 413 household contacts, RV was detected in 9 (2%) of whom 6 developed diarrhoea. RV was not found in age-matched healthy controls. In a serological study, the serological response was 81% in rotavirus diarrhoea cases (17 out of 21) by ELISA. By the ELISA blocking test, the seroconversion rate was only 29.6% in rotavirus diarrhoea cases (8 out of 27) and in others, 2 out of 71 cases (2.6%) who also showed serological response did not have rotavirus in their stools. This study indicates role of rotavirus in causing acute diarrhoea in young children, suggests a guideline for diagnosis and management of the patients. The rotavirus immunization should be considered if the vaccine becomes available in the near future.
D000208:Acute Disease; D000914:Antibodies, Viral / Q000096:biosynthesis; D002675:Child, Preschool; D003906:Developing Countries; D003967:Diarrhea / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D003968:Diarrhea, Infantile / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007223:Infant; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D013785:Thailand
D000914:Antibodies, Viral