Comparison of LATS activity and TSH receptor antibody in Graves' disease.
TSH-receptor antibody (TRAb) activity and LATS activity of Graves' sera were compared. All of 50 LATS-positive cases were TRAb positive, although only 63% of LATS-negative cases were TRAb positive. Binding of 125I-TSH to the TSH receptors was inhibited dose-dependently by LATS-immunoglobulin. However, no correlation between TRAb activity and LATS activity was observed. TRAb was positive in 2 LATS-positive cases even when the symptoms of hyperthyroidism were controlled by treatment (antithyroid or radioisotope). The positive TRAb was not changed in 4 Graves' disease patients whose LATS activity had disappeared following antithyroid treatment. These clinical studies show that TRAb is more sensitive than LATS and suggest that LATS may be one of a heterogenous population of antibodies to the TSH receptor in Graves' disease.
D001323:Autoantibodies; D006111:Graves Disease / Q000276:immunology* / Q000628:therapy; D006801:Humans; D008135:Long-Acting Thyroid Stimulator / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*; D011989:Receptors, Thyrotropin
D001323:Autoantibodies; D011956:Receptors, Cell Surface; D011989:Receptors, Thyrotropin; D008135:Long-Acting Thyroid Stimulator