[Effect of beta-phenylethylamine on synaptosomal and glial transport of labeled neuromediators].
The effect of beta-phenylethylamine (beta-PEA) on the accumulation of 14C-serotonin, 14C-glutamate and 3H-gamma-aminobutyric acid (3H-GABA) by synaptosomes of the caudate nucleus and cerebral cortex of rats and rabbits was studied for the first time. beta-PEA inhibits 14C-serotonin influx and exerts no material effect on 14C-glutamate and 3H-GABA uptake. beta-PEA inhibits the synaptosomal and glinal accumulation approximately to the same extent. The data obtained are in good agreement with the concepts of the regulatory role of beta-PEA in the transport of biogenic monoamines in the nerve ending membranes. A similarity of the inhibitory effects of beta-PEA to those of amphetamine is suggested.
D015078:2-Hydroxyphenethylamine / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003864:Depression, Chemical; D005971:Glutamates / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010627:Phenethylamines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005971:Glutamates; D018377:Neurotransmitter Agents; D010627:Phenethylamines; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D015078:2-Hydroxyphenethylamine
Vliianie beta-fenilétilamina na sinaptosomal'nyĭ i glial'nyĭ transport mechenykh neĭromediatorov.