Comparison of ranitidine and cimetidine in the inhibition of histamine, sham-feeding, and meal-induced gastric secretion in duodenal ulcer patients.
The effects of ranitidine, a new H2-receptor antagonist which does not contain an imidazole ring, and cimetidine have been determined on histamine, meal-induced gastric acid secretion, and serum gastrin levels in duodenal ulcer patients. Compared with cimetidine, ranitidine was found to be about eight times more potent an inhibitor of histamine-induced secretion and four to five times more potent an inhibitor of sham-feeding, and real feeding induced acid secretion without effecting serum gastrin levels.
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology* / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005663:Furans / Q000494:pharmacology* / Q000627:therapeutic use; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006146:Guanidines / Q000494:pharmacology*; D006632:Histamine; D006635:Histamine H2 Antagonists; D006801:Humans; D011899:Ranitidine
D005663:Furans; D005755:Gastrins; D006146:Guanidines; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D006632:Histamine; D011899:Ranitidine