[Morphofunctional changes in the sex gland of rats during stimulation and blockade of the M- and N-cholinoreactive systems].
The cholinergic agents arecolin, nicotin, amizil and etherofen induced morphofunctional changes in the testes as shown by experiments on white male rats. The drugs in a dose of 1 mg/kg stimulated hormonogenesis of the testicle. The cholinoblockers amizil and etherofen in a dose of 5 mg/kg strongly inhibited androgenic production. All the substances disturbed spermatogenesis, whose intensity depended on the action and doses of the drugs.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001535:Benactyzine / Q000494:pharmacology*; D004158:Diphenylacetic Acids / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D012670:Seminiferous Epithelium / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000503:physiopathology; D013997:Time Factors
D004158:Diphenylacetic Acids; C002675:ethyldiphacil; D001115:Arecoline; D001535:Benactyzine; D009538:Nicotine
Morfofunktsional'nye izmeneniia v polovoĭ zheleze krys pri vozbuzhdenii i blockade M- i N-kholinoreaktivnykh sistem.