title: Metabolism of adiphenine. I. Absorption, distribution and excretion in rats and mice.
abstract: 1. The disposition of adiphenine labelled with 14C in two positions has been investigated in rats and mice after i.v. administration, and has been compared with that of the [14C]diethylethanolamine HCl and of the [14C]diphenylacetic acid. 2. Radioactivity in the blood declined in a biphasic manner. Biliary elimination depended upon the 14C-labelled compound administered: less than 5% dose for the diethylethanolamine moiety, 100% dose for the carboxylic moiety. Of the radioactivity appearing in rat bile, less than 1% is associated with unchanged adiphenine. 3. In preliminary metabolic studies, three major metabolites have been identified: diphenylacetic acid, diethylethanolamine and a diphenylacetic acid glucuronide. 4. Uptake by the brain of [14C]adiphenine shortly after dosing is 15 times greater than that of blood. Radioactivity is also found in the hypophysis, the adrenals and melanoid pigments, with a concn. up to 30 times greater than that found in the blood.
mesh_terms: D000042:Absorption; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004158:Diphenylacetic Acids / Q000378:metabolism*; D004983:Ethanolamines / Q000378:metabolism; D007700:Kinetics; D008168:Lung / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution
chemical_list: D004158:Diphenylacetic Acids; D004983:Ethanolamines; C007369:2-diethylaminoethanol