Size determination of binding polymers for [3H]imipramine and [3H]paroxetine in human platelet membranes.
Imipramine and paroxetine both inhibit the transport of serotonin in serotonergic neurons and in platelets; furthermore specific high affinity binding sites for [3H]imipramine and [3H]paroxetine are located in these two cell types, probably on the serotonin transport mechanism. However, previous studies indicated that the binding site for [3H]imipramine was different from the binding site for [3H]paroxetine. We now report that the polymers on which the two binding sites are located have different molecular weights.
D001792:Blood Platelets / Q000378:metabolism* / Q000528:radiation effects; D002352:Carrier Proteins; D002462:Cell Membrane / Q000378:metabolism; D004583:Electrons; D006801:Humans; D007099:Imipramine / Q000097:blood*; D066298:In Vitro Techniques; D008565:Membrane Proteins / Q000097:blood; D008970:Molecular Weight; D017374:Paroxetine; D010880:Piperidines / Q000097:blood*; D011485:Protein Binding; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D012702:Serotonin Antagonists / Q000097:blood*
D002352:Carrier Proteins; D008565:Membrane Proteins; D010880:Piperidines; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D012702:Serotonin Antagonists; C027775:imipramine receptor; D017374:Paroxetine; D007099:Imipramine