Pharmacology of 2-o-chlororbenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S), a compound with benzodiazepine-like properties.
2-o-Chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S), a dipeptido-aminobenzophenone compound, inhibited pentetrazole-induced convulsion and suppressed electroshock-induced fighting behavior in mice, reduced conflict behavior in rats and monkeys, and induced muscle relaxation in cats at lower doses than did diazepam. This pharmacological profile suggests that 45-0088-S can be an active, water-soluble antianxiety agent in man.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000633:toxicity; D000927:Anticonvulsants; D001288:Attention / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects; D001577:Benzophenones / Q000633:toxicity; D002415:Cats; D004347:Drug Interactions; D005998:Glycine / Q000031:analogs & derivatives / Q000633:toxicity; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central; D051381:Rats
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001577:Benzophenones; D006993:Hypnotics and Sedatives; D009125:Muscle Relaxants, Central; C026735:2-(2-chlorobenzoyl)-4-chloro-N-methyl-N'-glycylglycinanilide; D005998:Glycine