title: [Distribution of dichlorvos in the rat and the effect of clinoptilolite on poisoning].
abstract: In the first series of trials, the physiological values of tissue cholinesterases were determined in the male rats of the Wistar strain. In the second series of trials the rats were perorally intoxicated with dichlorvos at the doses of 200.0, 128.0, 81.9, 65.5 and 52.4 mg per kg live weight. The objective of the trials was to examine the distribution of dichlorvos in the body of a rat on the basis of tissue cholinesterase inhibition. A marked decrease in the level of tissue cholinesterases was recorded at all the dichlorvos doses. In the third series of trials the protective effect of clinoptilolite was verified; clinoptilolite as a sorbent of natural origin has been administered per os at the dose of 1.0 g per kg live weight just before the intoxication with dichlorvos. The results document a marked protective effect of clinoptilolite on most of the tissues studied.
mesh_terms: D000538:Aluminum Silicates / Q000494:pharmacology*; D000818:Animals; D002802:Cholinesterases / Q000378:metabolism; D004006:Dichlorvos / Q000378:metabolism* / Q000506:poisoning; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D017641:Zeolites
chemical_list: D000538:Aluminum Silicates; D017641:Zeolites; D004006:Dichlorvos; D002802:Cholinesterases
vernacular_title: Distribúcia dichlórvosu v organizme krýs a vplyv klinoptilolitu na intoxikáciu.