Sympathetic influences in myocardial ischemia: possible mechanisms of arrhythmogenesis.
The large-scale trials of beta-adrenergic receptors have indicated a clear-cut benefit in patients having survived an acute myocardial infarction. At present, we do not understand the mechanism for these results, which impairs our ability to totally prevent mortality from myocardial infarction with beta blockade therapy. This review was aimed at the considerable recent experimental and clinical observations in adrenergic influences on the myocardial ischemia. Based on these and future studies, other manipulations of the sympathetic nervous system may prove helpful in preventing ventricular arrhythmias associated with coronary artery disease.
D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001792:Blood Platelets / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology*; D000242:Cyclic AMP / Q000032:analysis; D004562:Electrocardiography; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000032:analysis; D012032:Refractory Period, Electrophysiological; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D009638:Norepinephrine