Effects of apamin on the outward potassium current of isolated frog skeletal muscle fibres.
The effect of apamin, a polypeptidic toxin from bee venom which is a specific blocker of certain Ca2+-dependent K+ channels, has been tested (50-100nM) on voltage clamped single skeletal muscle fibres of the frog. The results have shown the existence of an inhibitory effect of the toxin on the slow outward K+ current which suggests the existence of a Ca2+-sensitive component of the slow K+ permeability in the plasma membrane of the frog muscle fibre.
D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D009132:Muscles / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D011895:Rana ridibunda
D001514:Bee Venoms; D007473:Ion Channels; D001030:Apamin; D011188:Potassium