title: Ketamine for minor gynecologic surgery.
abstract: Lorazepam, a benzodiazepine derivative, is a hypnotic useful for premedication. Four milligrams given orally, intramuscularly or intravenously, is more effective than many other agents, including diazepam, in attenuating the psychic sequelae of ketamine administration. This study compares the efficacy of intravenous administration of 2 mg of lorazepam with that of 10 mg of diazepam. The results reveal that the lower dose of lorazepam is superior to 10 mg of diazepam in taming ketamine sequelae. Therefore, lorazepam is suggested for use instead of the higher dose of diazepam.
mesh_terms: D000328:Adult; D000758:Anesthesia; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007649:Ketamine; D008140:Lorazepam / Q000494:pharmacology*; D008875:Middle Aged; D011229:Preanesthetic Medication
chemical_list: D014151:Anti-Anxiety Agents; D007649:Ketamine; D008140:Lorazepam; D003975:Diazepam