title: Uptake and subcellular distribution of 65zinc in brain structures during the postnatal development of the rat.
abstract: The uptake ratio of 65zinc into the postnatally developing hippocampal formation, cerebellum and remainder of the brain showed only minor differences, whilst following subcellular fractionation a marked decrease in 65zinc uptake from postnatal day 15 to adulthood was found in nuclear sediments (hippocampal formation 44.3%, cerebellum 27.5%), along with an increase in synaptosomal fractions on the hippocampal formation by 55.4% and of the cerebellum by 37.1%. The shift of zinc out of the perikarya into terminal fields during the postnatal development without substantial alterations of the net zinc content is supposed to be a consequence of a functional relation of zinc to synaptic transmission processes.
mesh_terms: D000367:Age Factors; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002531:Cerebellum / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism; D009435:Synaptic Transmission; D015032:Zinc / Q000378:metabolism*
chemical_list: D015032:Zinc