title: Genetic changes in mammalian cells reminiscent of an SOS response.
abstract: Prior to the isolation of mammalian DNA repair genes and identification of their gene products, the comparison between the bacterial SOS response and various similar reactions in mammalian cells remains rather speculative. The increasing number of observed phenomena including enhanced DNA repair, virus induction, induced cellular differentiation, and neoplastic transformation, all following DNA damage or arrest of replication, are, however, suggestive of an SOS-like system of growth control and may form an entry into this fascinating area.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000235:genetics*; D004260:DNA Repair; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D005784:Gene Amplification; D005786:Gene Expression Regulation; D005796:Genes; D005798:Genes, Bacterial; D006801:Humans; D008324:Mammary Tumor Virus, Mouse / Q000254:growth & development; D009154:Mutation; D010641:Phenotype; D013539:Simian virus 40 / Q000254:growth & development; D014775:Virus Activation
chemical_list: D004269:DNA, Bacterial; D004247:DNA