The effects of pindolol and prazosin on hand blood flow in patients with cold extremities and on treatment with beta-blockers.
Hand blood flow and subjective sensitivity to cold were studied in nine hypertensive patients on treatment with beta-blockers. All patients complained of cold extremities. Neither hand blood flow nor sensitivity to cold changed after addition of prazosin, a well known vasodilator to the original beta-blocker. After changing to a beta-blocker with a high degree of intrinsic sympathomimetic activity (pindolol), hand blood flow increased and sensitivity to cold decreased in all patients, except one.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D001262:Atenolol / Q000009:adverse effects / Q000627:therapeutic use*; D003080:Cold Temperature; D005260:Female; D006225:Hand / Q000098:blood supply*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology*; D011412:Propanolamines / Q000627:therapeutic use*; D011799:Quinazolines / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D011799:Quinazolines; D001262:Atenolol; D010869:Pindolol; D011224:Prazosin