Metabolism and disposition of erythro-9-(2-hydroxy-3-nonyl)[14C]adenine in the rhesus monkey.
erythro-9-(2-Hydroxy-3-nonyl)[14C]adenine was extensively metabolized by monkeys. Following iv administration of 5 mg/kg, serum levels of total radioactivity increased to a maximum between 15 and 30 min, then dropped rapidly. Thin-layer chromatography of extracts of liver, kidney, and urine revealed four metabolites. Of the radioactivity administered, urinary excretion accounted for 70% within 6 hr and 90% within 1 week. In serum, the concentration of intact drug declined rapidly; in urine, it constituted less than 0.3% of the total radioactivity.
D000225:Adenine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D005260:Female; D000882:Haplorhini; D007166:Immunosuppressive Agents / Q000378:metabolism*; D008253:Macaca mulatta; D013997:Time Factors; D014018:Tissue Distribution
D007166:Immunosuppressive Agents; C010192:9-(2-hydroxy-3-nonyl)adenine; D000225:Adenine