[Induction of unstable mutations in Drosophila melanogaster by the microinjection of oncogenic viruses and their DNA into early embryos].
RNA-containing Raus sarcoma virus, recombinant plasmid pBR322 inserted by kDNA RSV (pPrC11) and Sa7 adenovirus DNA were injected into the polar region of Drosophila melanogaster early embryons. The exogenic genetic material injected was shown to induce mutations, many of them unstable. In a number of cases, virus-specific sequences were found in DNA isolated from mutant flies. It is hypothesized that mutations induced by DNA of oncogenic viruses are of the insertion type.
D000261:Adenoviruses, Simian / Q000235:genetics; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics; D003001:Cloning, Molecular / Q000379:methods; D004247:DNA / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics*; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D008845:Microinjections; D009154:Mutation; D009693:Nucleic Acid Hybridization; D009858:Oncogenic Viruses / Q000235:genetics*; D010957:Plasmids
D004279:DNA, Viral; D004247:DNA
Induktsiia nestabil'nykh mutatsiĭ u Drosophila melanogaster mikroin''ektsieĭ onkogennykh virusov i ikh DNK v rannie émbriony.