title: Synthesis and radiochemical stability of 14C-cefotaxime.
abstract: 14C-Cefotaxime (14C-HR 756) has been synthesised with the radiolabel in the sidechain aminothiazole ring by a multistep sequence starting from 14C-thiourea. A high specific activity batch (10400 microCi g-1), and a low specific activity batch (57.1 microCi g-1) suitable for intravenous human use were prepared; their purity, and solid-state and aqueous solution stability, are described.
mesh_terms: D002250:Carbon Radioisotopes; D002439:Cefotaxime / Q000138:chemical synthesis*; D004355:Drug Stability; D007553:Isotope Labeling; D012996:Solutions
chemical_list: D002250:Carbon Radioisotopes; D012996:Solutions; D002439:Cefotaxime