Insulin release by trimetoquinol in normal and asthmatic subjects.
The existence of beta 2-adrenergic receptor in pancreatic beta-cell was evaluated. Significantly low beta 2-stimulant responsiveness of pancreatic beta-cell was observed in continuously medicated and active asthmatic subjects, indicating beta-adrenergic blockade state. This low responsiveness recovered in the inactive stage of asthma and with hydrocortisone treatment.
D000293:Adolescent; D000317:Adrenergic alpha-Antagonists; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001786:Blood Glucose; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000166:cytology; D013997:Time Factors; D014213:Tretoquinol / Q000008:administration & dosage / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D001786:Blood Glucose; D007328:Insulin; D007546:Isoquinolines; D014213:Tretoquinol; D006854:Hydrocortisone