Studies of N-methyl-N'-nitro-N-nitrosoguanidine action on the guanylate cyclase-guanosine 3'5' monophosphate system of isolated colonic epithelial cells.
D000818:Animals; D001711:Biotransformation; D003106:Colon / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D004229:Dithiothreitol / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D006162:Guanylate Cyclase / Q000378:metabolism*; D006418:Heme / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D011817:Rabbits
D009573:Nitrites; D008769:Methylnitronitrosoguanidine; D009569:Nitric Oxide; D006418:Heme; D000242:Cyclic AMP; D006162:Guanylate Cyclase; D006152:Cyclic GMP; D004229:Dithiothreitol