title: Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man.
abstract: To determine whether the topical or systemic effects of aspirin are of greater importance in the production of gastroduodenal mucosal damage, the effects of regular and enteric-coated aspirin were compared in 9 healthy volunteers in a 2-week crossover endoscopic study. All subjects developed multiple gastric erosions while taking regular aspirin; 2 subjects developed one gastric erosion each while taking enteric-coated aspirin. 5 subjects developed duodenal erosions while taking regular aspirin, whereas none developed an erosion while taking enteric-coated aspirin. Mean fasting salicylate levels were similar in the two groups. It is concluded that regular aspirin causes a greater amount of gastroduodenal mucosal damage than does enteric-coated aspirin despite similar serum-salicylate levels. This suggests that the topical effects of aspirin are of greater importance than the systemic effects in the production of gastroduodenal mucosal damage in healthy subjects.
mesh_terms: D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D004378:Duodenal Diseases / Q000139:chemically induced; D004386:Duodenum / Q000187:drug effects; D004890:Erythema / Q000139:chemically induced; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects*; D011706:Pyloric Antrum / Q000187:drug effects; D012459:Salicylates / Q000097:blood; D013272:Stomach Diseases / Q000139:chemically induced; D013608:Tablets, Enteric-Coated
chemical_list: D012459:Salicylates; D013608:Tablets, Enteric-Coated; D001241:Aspirin