Direct action of somatostatin on dispersed mucosal cells from guinea-pig stomach.
In dispersed mucosal cells from guinea-pig stomach, somatostatin inhibited in a noncompetitive fashion (Ki, 2 x 10(-8) M) the increase in cellular cyclic AMP caused by histamine but not by prostaglandin E1 or phosphodiesterase inhibitors. Somatostatin also inhibited the increase in [14C]aminopyrine uptake caused by low concentrations of histamine probably by interfering with the synthesis of cellular cyclic AMP.
D000527:Alprostadil; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000378:metabolism; D010726:Phosphodiesterase Inhibitors / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*
D006633:Histamine Antagonists; D010726:Phosphodiesterase Inhibitors; D011458:Prostaglandins E; D000632:Aminopyrine; D013004:Somatostatin; D000242:Cyclic AMP; D000527:Alprostadil