[Inhibition of the multiplication of human herpes virus I by prostaglandin D2 and the synergistic effect of human leukocyte interferon].
The effect of prostaglandin D2 (PGD2) on the herpes simplex virus (HSV) growth was examined. It was confirmed that PGD2 inhibited the HSV growth in the FL cell culture, and the degree of the inhibition was dependent on the concentration of PGD2. PGD2 inhibited the HSV growth only when the cells were treated with PGD2 after the HSV adsorption. It was also confirmed that human leukocyte interferon (IFN) and PGD2 showed the synergistic effect on the inhibition of HSV growth.
D004357:Drug Synergism; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects*
D007370:Interferon Type I; D011457:Prostaglandins D; D015230:Prostaglandin D2
Inhibition de la multiplication du virus de l'herpès humaine I par la prostaglandine D2 et effet synergique de l'intféron leucocytaire humain.