Rubella viraemia and antibody responses after rubella vaccination and reimmunization.
Eleven 4-13 year old schoolgirls, who were seronegative by haemagglutination inhibition (HI) and radioimmunoassay (RIA) tests despite having been given HPV77-DE5 vaccine 3-9 years previously, were revaccinated with RA27/3. They showed evidence of residual immunity since they had accelerated immune responses, little or no rubella-specific IgM, no viraemia, and no vaccine-induced reactions. In contrast, all but one of the five adult women who were primary vaccinees showed a more delayed immune response. Three of four women tested had viraemia and two had vaccine-induced reactions. Enhanced HI and enhanced RIA showed that many of the schoolgirls had antibody before challenge, as did a fifth adult, who also showed an accelerated immune response, yet became viraemic.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007075:Immunoglobulin M / Q000032:analysis; D012409:Rubella / Q000276:immunology* / Q000517:prevention & control; D012412:Rubella virus / Q000276:immunology*; D014611:Vaccination / Q000009:adverse effects; D014766:Viremia / Q000209:etiology / Q000276:immunology*
D000914:Antibodies, Viral; D007075:Immunoglobulin M