[Changes in the density of human lymphocyte beta-adrenergic receptors in hypertension].
The beta-adrenoreceptor density in intact lymphocytes of peripheral blood of normotensive and hypertensive adults was measured by the radioligand binding technique with the use of 3H-dihydroalprenolol. The density of beta-adrenoreceptors was found to be higher in lymphocytes of hypertensive subjects while the number of the receptors was equal to 2076 +/- 208 and 1461 +/- 175 receptors per cell, respectively, in hypertensive and normotensive subjects. The dissociation constants in both cases varied from 0.4 to 1.8 nM. Probably, the decreased responses to the adrenergic agents in hypertensive subjects are not connected with the decreased number of beta-adrenoreceptors and may be due to alterations in postreceptor events.
D000328:Adult; D000526:Alprenolol / Q000097:blood; D004082:Dihydroalprenolol / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D010646:Phentolamine / Q000097:blood; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D000526:Alprenolol; D010646:Phentolamine
Izmenenie plotnosti beta-adrenergicheskikh retseptorov limfotsitov cheloveka pri gipertonicheskoĭ bolezni.