The effect of oral contraceptives on serum lipids gamma-glutamyl transpeptidase, and excretion of d-glucaric acid.
The authors studied three oral contraceptives (Bisecurin, Ovidon, Rigevidon) in 37 healthy women in order to establish their effect on serum lipids, gamma-glutamyl transpeptidase and d-glucaric acid excretion. After 3-9 months of oral contraception, a significant increase was observed in serum cholesterol and beta-lipoprotein levels in women taking the two contraceptives with major hormone content. None of the contraceptives changed the serum glyceride level. Serum gamma-glutamyl transpeptidase levels were significantly enhanced. D-glucaric acid excretion increased. There was no correlation between the parameters of enzyme induction and the change of lipid metabolism.
D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000097:blood; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D005260:Female; D005937:Glucaric Acid / Q000652:urine*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008862:Microsomes, Liver / Q000378:metabolism; D013400:Sugar Acids / Q000652:urine*; D014280:Triglycerides / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood*
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D008055:Lipids; D013400:Sugar Acids; D014280:Triglycerides; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D005937:Glucaric Acid