Brain capillary guanosine triphosphatase: a distinction from adenosine triphosphatase.
Differences in kinetic properties, pH response, sensitivity to ouabain, and disc-acrylamide electrophoresis resolution, are observed when GTP and ATP are used as the substrates for triphosphohydrolases in isolated rat brain microvessels. In brain parenchyma there are no such differences. It is concluded that substrate-specific GTPase exists in brain microvessels.
D000251:Adenosine Triphosphatases / Q000032:analysis*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000201:enzymology; D004591:Electrophoresis, Polyacrylamide Gel; D020558:GTP Phosphohydrolases / Q000032:analysis*; D006160:Guanosine Triphosphate / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008833:Microcirculation / Q000032:analysis; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis*; D051381:Rats; D013379:Substrate Specificity
D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D010744:Phosphoric Monoester Hydrolases; D000251:Adenosine Triphosphatases; D020558:GTP Phosphohydrolases