Effect of different psychoactive drugs on serum and brain tryptophan levels.
A considerable amount of evidence indicates that the brain tryptophan level depends on circulating tryptophan. Changes of tryptophan concentration have also been described to modify the activity of benzodiazepines and tricyclic antidepressants. In the present study, a series of psychoactive drugs have been preliminarily screened for their activity on brain and plasma tryptophan levels. The results obtained suggest that tryptophan may be involved to varying extents in the activity of different psychoactive compounds.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D001463:Barbiturates / Q000494:pharmacology; D001569:Benzodiazepines; D001923:Brain Chemistry / Q000187:drug effects*; D002090:Butyrophenones; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D008297:Male; D051379:Mice; D010640:Phenothiazines; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D014364:Tryptophan / Q000032:analysis* / Q000097:blood
D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D001463:Barbiturates; D002090:Butyrophenones; D000697:Central Nervous System Stimulants; D010640:Phenothiazines; D011619:Psychotropic Drugs; D001569:Benzodiazepines; D014364:Tryptophan; D010889:Piracetam