Is the relative 99mTc-DMSA clearance a useful marker of proximal tubular dysfunction?
The clearance of 125I-sodium iothalamate, 131I-sodium hippurate, 99mTc-DMSA, and beta 2-microglobulin were determined in 20 patients with proven or suspected proximal tubular dysfunction and in 18 control patients with various renal diseases. A clear distinction in the relative 99mTc-DMSA clearance was observed between patients with proximal tubulopathy (14%-35%) and control patients (less than 14%). A similar difference between the two groups was found in the relative beta 2-microglobulin clearance. Nine patients with proximal tubulopathy showed an elevated filtration fraction versus only two control patients. The renal handling of 99mTc-DMSA seems to be an indicator of proximal tubular function.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005919:Glomerular Filtration Rate; D006626:Hippurates / Q000378:metabolism; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D007483:Iothalamic Acid / Q000378:metabolism; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012079:Renal Circulation; D004113:Succimer; D013438:Sulfhydryl Compounds; D013667:Technetium; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D001613:beta 2-Microglobulin / Q000378:metabolism
D006626:Hippurates; D007457:Iodine Radioisotopes; D013438:Sulfhydryl Compounds; D001613:beta 2-Microglobulin; D007483:Iothalamic Acid; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013667:Technetium; D004113:Succimer