[Induction of mixed microsomal oxidase in experimental hexachlorobenzene porphyria in rabbits].
The chlororganic pesticide--hexachlorbenzol (C6Cl6), given to rabbits, induces the clinical picture and biochemical changes of porphyria cutanea tarda. The experiments are carried out on 40 rabbits of Chinchilla strain. Microsomal protein and the enzymes cytochrom P-450, aniline-hydroxylase, aminopyrine-dimetilase are determined in liver microsomes, obtained by differential centrifugation. The mitochondrial enzyme Deltaaminolevuline acid-syntatese (DALA-syntatase) is determined in liver homogenate as well as the enzyme gamma-glutamyl-transpeptidase (GGTP) in serum and uro- and coproporphyrines in urine. Hexachlorbenzol Induces strongly enzymes DALA-syntatase and GGTP. Its effect on the microsomal enzymes does not differ from the effect of other typical microsomal inductors. The most probable action of hexachlorbenzol are two different phenomene.
D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis; D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000815:Aniline Hydroxylase / Q000096:biosynthesis; D000818:Animals; D002722:Chlorobenzenes / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D006581:Hexachlorobenzene / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000201:enzymology*; D010088:Oxidoreductases / Q000096:biosynthesis*; D011164:Porphyrias / Q000139:chemically induced / Q000201:enzymology*; D011817:Rabbits; D012871:Skin Diseases / Q000139:chemically induced / Q000201:enzymology*; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis
D002722:Chlorobenzenes; D006581:Hexachlorobenzene; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D000624:5-Aminolevulinate Synthetase; D005723:gamma-Glutamyltransferase
Induktsiia na smesenata mikrozomna oksidaza pri eksperimentalna kheksakhlorbenzolova porfiriia u zaĭtsi.