Barrel rotation induced by vasopressin and involvement of dopaminergic and cholinergic functions in rats.
Intraventricular administration of 1,6-aminosuberyl-arginine8-vasopressin or somatostatin in rats barrel rotation, a peculiar rotation along the sagittal body axis. The vasopressin-induced barrel rotation was markedly enhanced by fluphenazine, haloperidol, 6-hydroxydopamine or alpha-methyl-p-tyrosine but was unaffected by (D-Ala2, MePhe4, Met(O)5-ol)-enkephalin. The enhancement of the rotation behavior of fluphenazine was prevented by pretreatment with trihexy-phenidyl a muscarinic receptor blocker. These observations clearly show that vasopressin can elicit barrel rotation and that dopaminergic inhibition and cholinergic activation are concomitantly involved.
D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004347:Drug Interactions; D005476:Fluphenazine / Q000494:pharmacology; D006801:Humans; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*; D014282:Trihexyphenidyl / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D013004:Somatostatin; D014282:Trihexyphenidyl; D005476:Fluphenazine; D004298:Dopamine