Sodium appetite decreased by central angiotensin blockade.
Disturbances in body water and electrolytes that trigger sodium appetite, such as sodium depletion or hypovolemia, are potent activators of the renin-angiotensin system. In the absence of an actual deficit in body fluids, angiotensin injections are adequate to stimulate increased sodium ingestion. To assess whether angiotensin is a significant mediator of sodium appetite induced by acute alterations in body fluids, sodium intake was examined in rats during central or peripheral angiotensin blockade. Central blockade of angiotensin receptors by intracerebroventricular (ICVT) injection of the analogue antagonist saralasin decreased (but did not eliminate) sodium intake after polethylene glycol-induced hypovolemia or sodium depletion resulting from dialysis against glucose. Conversely, peripheral blockade of angiotensin converting enzyme with orally active captopril potentiated rather than decreased sodium appetite and stimulated water intake after sodium depletion. This increased water and salt intake after peripheral inhibition of converting enzyme was reversed, however, by concurrent central blockade of angiotensin receptors. These data support the hypothesis that angiotensin participates in sodium appetite associated with acute alteration in body fluids. Furthermore, the brain is the site at which angiotensin exerts its influence on sodium appetite. While the involvement of angiotensin of brain origin is not ruled out, the change in sodium appetite after peripheral blockade of converting enzyme suggests that circulating angiotensin derived from renal renin may interact with central angiotensin receptors regulating sodium appetite.
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001066:Appetite / Q000502:physiology*; D001067:Appetite Depressants; D001921:Brain / Q000502:physiology*; D002216:Captopril / Q000494:pharmacology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology; D012964:Sodium; D014882:Water-Electrolyte Balance
D001067:Appetite Depressants; D000804:Angiotensin II; D002216:Captopril; D012964:Sodium; D007703:Peptidyl-Dipeptidase A; D012504:Saralasin