title: [Pituitary adenoma secreting somatotropic hormone. Gigantism and peripheral neuropathy. A case].
abstract: Gigantism, an extremely rare condition, develops before puberty or in subjects in whom puberty is not yet completed. Hypersecretion of somatotropic hormone results in a tremendous surge in growth (our patient was 2.36 m tall). Among other clinical symptoms disabling peripheral neuropathy predominates and changes in nerve conduction velocity are not merely due to the increase in height. The increase in growth hormone concentrations combined with hypogonadotrophic hypogonadism with normal prolactinaemia is associated with peculiar cutaneous symptoms and with low levels of sex hormone-binding protein.
mesh_terms: D000236:Adenoma / Q000150:complications / Q000378:metabolism*; D000328:Adult; D005877:Gigantism / Q000209:etiology* / Q000503:physiopathology; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology; D007866:Leg / Q000294:innervation; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism*; D013997:Time Factors
chemical_list: D013006:Growth Hormone
vernacular_title: Adénome hypophysaire sécrétant de l'hormone somatotrope. Gigantisme et neuropathie périphérique. Une observation.