Comparison of four different beta-adrenoceptor blocking drugs on lymphocyte isoprenaline-stimulated cyclic AMP production.
1 The influence of acebutolol, atenolol, pindolol and timolol on human lymphocyte cyclic AMP (cAMP) and its stimulation by isoprenaline in vitro has been studied. 2 Acebutolol and atenolol (10(-8)-10(-6)M) had no significant influence on lymphocyte cAMP levels or on isoprenaline-stimulated increase in cAMP. 3 Pindolol and timolol significantly antagonised the effect of isoprenaline, and pA2 values were calculated to be 8.12 and 8.04 respectively. This suggests that beta 2-adrenoceptors are involved in this phenomenon. 4 Only pindolol produced a significant increase in lymphocyte cAMP, which is consistent with its partial agonist activity.
D000070:Acebutolol / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001262:Atenolol / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000494:pharmacology; D013999:Timolol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D000070:Acebutolol; D013999:Timolol; D010869:Pindolol; D000242:Cyclic AMP; D007545:Isoproterenol