title: Kinetics of drug decomposition. Part 69: Effect of excipients on the thermal decomposition of the mixture of aminophenazone allobarbital and adiphenine hydrochloride in the solid.
abstract: By the method of accelerated testing at elevated temperature, the thermal decomposition rate of the mixture of aminophenazone (AP), allobarbital (AB) and adiphenine hydrochloride (AD) and its individual components in the presence of the excipients starch (potato), agar, talcum, kaolin and magnesium stearate is studied. The individual and joint effect of the excipients on the components of the mixture AP + AB + AD as well as on the mixture as a whole is determined and compared. The theoretically predicted stability of the components is discussed and compared with the results of "self-life" tests in the presence and absence of the excipients.
mesh_terms: D000632:Aminopyrine / Q000032:analysis*; D001463:Barbiturates / Q000032:analysis*; D004158:Diphenylacetic Acids / Q000032:analysis*; D004338:Drug Combinations; D004355:Drug Stability; D005079:Excipients; D006358:Hot Temperature; D007700:Kinetics; D013607:Tablets; D013816:Thermodynamics
chemical_list: D001463:Barbiturates; D004158:Diphenylacetic Acids; D004338:Drug Combinations; D005079:Excipients; D013607:Tablets; D000632:Aminopyrine