title: Opiate binding in the rat spinal cord: evidence for mu and delta sites.
abstract: The presence of binding sites for ligands of mu and delta, in addition to kappa selectivity, have been demonstrated in the lumbo-sacral spinal cord of the rat by direct binding of [3H]ligands. These findings have been confirmed by competition studies. This information helps explain the observed pharmacology of opioids after intrathecal administration.
mesh_terms: D000818:Animals; D001575:Benzomorphans / Q000378:metabolism; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000378:metabolism; D016308:Enkephalin, Leucine-2-Alanine; D004745:Enkephalins / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009294:Narcotics / Q000378:metabolism; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism*; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D001575:Benzomorphans; D004745:Enkephalins; D009294:Narcotics; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C027248:bremazocine