The antiviral spectrum of (E)-5-(2-bromovinyl)-2'-deoxyuridine.
The antiviral activity spectrum of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) is not restricted to herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) but also encompasses several other herpesviruses such as suid herpesvirus type 1 (SHV-1), bovid herpesvirus type 1 (BHV-1), simian varicella virus (SVV), herpesvirus saimiri, herpesvirus platyrrhinae, and the baculovirus Trichoplusia ni multiple nuclear polyhedrosis virus. Other herpesviruses such as herpes simplex virus type 2, cytomegalovirus and Epstein-Barr virus are also inhibited by BVdU, albeit to a lesser extent than HSV-1, VZV, SHV-1, BHV-1 and SVV.
D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003587:Cytomegalovirus / Q000187:drug effects; D004267:DNA Viruses / Q000187:drug effects; D007242:Herpesvirus 1, Bovine / Q000187:drug effects; D004861:Herpesvirus 1, Equid / Q000187:drug effects; D011558:Herpesvirus 1, Suid / Q000187:drug effects; D006567:Herpesvirus 2, Saimiriine / Q000187:drug effects; D014645:Herpesvirus 3, Human / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000187:drug effects; D007304:Insect Viruses / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine