The influence of various counter ions on the interaction of chlorhexidine with the hydrophilic contact lens polymer, poly(2-hydroxyethyl methacrylate).
The commercially available salts of chlorhexidine were found to interact with the hydrogel poly (2-hydroxyethyl methacrylate) to different extents, the affinity for the polymer decreasing in the order acetate, gluconate, chloride. The uptakes of the acetate and gluconate salts were almost entirely irreversible over the concentration range studied. The influence of some alternative counter ions, namely amino acids and dicarboxylic acid salts, was examined and found to generate a three-fold variation in the extent of the chlorhexidine interaction. Uptakes were greatest for counter ions that were either hydrophobic in character or bore a net negative charge. Only two compounds, glycine and monosodium oxalate, were successful in reducing the extent of sorption below that observed for chlorhexidine hydrochloride.
D000085:Acetates; D000180:Acrylic Resins; D000327:Adsorption; D000596:Amino Acids; D001665:Binding Sites; D002710:Chlorhexidine; D002712:Chlorides; D003263:Contact Lenses, Hydrophilic; D004347:Drug Interactions; D005942:Gluconates; D006801:Humans; D011102:Polyhydroxyethyl Methacrylate; D012995:Solubility; D013696:Temperature
D000085:Acetates; D000180:Acrylic Resins; D000596:Amino Acids; D002712:Chlorides; D005942:Gluconates; D011102:Polyhydroxyethyl Methacrylate; D002710:Chlorhexidine