Detection of respiratory syncytial virus serum antibodies by an ELISA system.
An ELISA test for respiratory syncytial (RS) virus assay was adapted and standardized; it gave 10-15 times higher antibody titres than complement fixation (CF) but was not a more sensitive test for detecting recent RS virus infection in persons above 1 year of age. In testing normal-population sers, ELISA revealed twice more positive sera than the CF test. Owing to its high sensitivity and apparent ability to detect long-persisting antibodies, ELISA is the test of choice for sero-epidemiological surveys on RS virus infections.
D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003289:Convalescence; D004797:Enzyme-Linked Immunosorbent Assay / Q000592:standards; D006801:Humans; D007124:Immunoenzyme Techniques / Q000592:standards; D007223:Infant; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000175:diagnosis; D010253:Respirovirus Infections / Q000175:diagnosis
D000914:Antibodies, Viral