The role of hormone receptors and GTP-regulatory proteins in membrane transduction.
Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D004789:Enzyme Activation; D006160:Guanosine Triphosphate / Q000502:physiology*; D006801:Humans; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000502:physiology; D011955:Receptors, Drug / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000502:physiology
D000067956:Adenylyl Cyclase Inhibitors; D002352:Carrier Proteins; D046911:Macromolecular Substances; D008565:Membrane Proteins; D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D006160:Guanosine Triphosphate; D000242:Cyclic AMP; D000262:Adenylyl Cyclases