[The state of hormonal homeostasis in patients with lung cancer under combined and radiation treatment].
Radioimmunologic evaluation of hormonal profile was performed in 200 lung cancer patients before and after combined and radiation treatment and in 25 healthy subjects (controls). The study showed an increase in the basal level of hormones of pituitary-adrenal system matched by a decline in thyroid function. Adequate combined and radiation treatment brought hormone levels to normal. Hormonal disorders accompanying recurrence were identical to those registered at disease onset. In some cases, changes in hormonal profile developed as early as 3-6 months prior to clinically manifest recurrences or dissemination.
D000230:Adenocarcinoma / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D002277:Carcinoma / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006706:Homeostasis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008175:Lung Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011379:Prognosis; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D006854:Hydrocortisone
Sostoianie gormonal'nogo gomeostaza u bol'nykh rakom legkogo pri kombinirovannom i luchevom lechenii.