title: Dimethylsulphoxide-induced toxicity.
abstract: Two elderly people were given intravenous infusion of dimethylsulphoxide (DMSO) as treatment for arthritis. One became seriously ill, the other remained well. Both had similar changes in aspartate transaminase, hydroxybutyrate dehydrogenase, and creatine kinase and evidence of haemolysis. This is the first report of serum enzyme changes and anaemia after intravenous DMSO in man.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D001168:Arthritis / Q000188:drug therapy; D002544:Cerebral Infarction / Q000139:chemically induced; D003404:Creatinine / Q000652:urine; D004121:Dimethyl Sulfoxide / Q000009:adverse effects*; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D008297:Male; D014508:Urea / Q000652:urine
chemical_list: D014508:Urea; D003404:Creatinine; D004121:Dimethyl Sulfoxide