title: Failure of targeted mass treatment to control schistosomiasis.
abstract: An attempt was made to control schistosomiasis mansoni with mass treatment of all subjects excreting more than 100 eggs/g of faeces. No other means of control to reduce transmission were used. A very low dosage of hycanthone (0.75 mg/kg) appeared insufficient to achieve a satisfactory reduction of the worm load. A higher dosage (1.5 mg/kg) resulted in a significant reduction of the egg output. However, reappearance of eggs, probably indicating reinfection, was very rapid. One year after treatment the egg counts were at about two-thirds of the original level again.
mesh_terms: D003140:Communicable Disease Control / Q000379:methods*; D015023:Democratic Republic of the Congo; D005243:Feces / Q000469:parasitology; D006801:Humans; D006826:Hycanthone / Q000627:therapeutic use; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000187:drug effects; D012552:Schistosomiasis / Q000517:prevention & control* / Q000635:transmission; D012556:Schistosomicides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D012556:Schistosomicides; D006826:Hycanthone