title: Localization of lysyl oxidase in hen oviduct: implications in egg shell membrane formation and composition.
abstract: Lysyl oxidase activity was found in the isthmus (the membrane-forming region) of the hen's oviduct in a copper-rich region proximal to the shell gland. Desmosine and isodesmosine, cross-linking compounds associated with mature elastin, were found in hydrolysates of the shell membrane, confirming the necessity for lysyl oxidase in its biosynthesis. Shell membranes from hens fed a copper-deficient diet or a diet supplemented with beta-aminopropionitrile had a reduced content of desmosine and isodesmosine.
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D003432:Cross-Linking Reagents; D003895:Desmosine / Q000032:analysis; D004528:Egg Shell; D007524:Isodesmosine / Q000032:analysis; D010057:Oviducts / Q000201:enzymology*; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism*
chemical_list: D003432:Cross-Linking Reagents; D003895:Desmosine; D003300:Copper; D007524:Isodesmosine; D000594:Amino Acid Oxidoreductases; D008249:Protein-Lysine 6-Oxidase