Effects of physostigmine on septo-hippocampal averaged evoked field potentials.
Field potentials were elicited in the CA3 field of freely-moving animals by paired-pulse stimulation of the ventral portion of the medial septum before and after exposure to physotigmine. Physostigmine had no effect on response components elicited by a single stimulus or by the first stimulus of a pulse pair. However, the amplitude of a late positive component elicited by the second stimulus of a pair was increased significantly following physostigmine. These results suggest that activity in a cholinergic portion of the septo-hippocampal pathway may serve to modulate the responsiveness of neurons in the CA3 field to subsequent stimulation.
D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D010830:Physostigmine