Evaluation of serum guanase in hepatic diseases.
Serum guanase activity was measured in 20 healthy adults and in 62 patients with acute viral hepatitis, chronic active hepatitis, chronic persistent hepatitis, liver  cirrhosis and fatty liver. Guanase and gamma-GT in patients were elevated in 87 and 64%, respectively. Elevated guanase activities were found in most cases of acute viral hepatitis, as well as in chronic hepatopathies. In patients with acute viral hepatitis pathologic activities of guanase were found following partial or total normalization of other liver function tests.
D000619:Aminohydrolases / Q000378:metabolism*; D003937:Diagnosis, Differential; D005235:Fatty Liver, Alcoholic / Q000175:diagnosis; D006148:Guanine Deaminase / Q000378:metabolism*; D006505:Hepatitis / Q000175:diagnosis; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis; D008107:Liver Diseases / Q000097:blood* / Q000175:diagnosis; D013379:Substrate Specificity; D014018:Tissue Distribution; D005723:gamma-Glutamyltransferase / Q000097:blood
D005723:gamma-Glutamyltransferase; D000619:Aminohydrolases; D006148:Guanine Deaminase