Pheochromocytoma producing immunoreactive ACTH with Cushing's syndrome.
A 42-year-old female with clinical and endocrine indications of Cushing's syndrome, as well as periodic hypertension and increased urinary catecholamines and their metabolites, benefitted from removal of a pheochromocytoma. Adrenocortical hyperplasia was present. Electron microscopy showed catecholamine-type granules in the tumor cells; in addition, immunoreactive ACTH, leu-enkephalin, somatostatin, and serotonin were identified. Such studies were performed for the first time in this unusual condition.
D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000473:pathology / Q000648:ultrastructure*; D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D000328:Adult; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D010673:Pheochromocytoma / Q000150:complications / Q000473:pathology / Q000648:ultrastructure*
D000324:Adrenocorticotropic Hormone