[Reduction of post-heparin lipoprotein lipase activity by acidotic blood pH].
Diseases associated with acidotic blood-pH, such as chronic renal disease, diabetes mellitus or chronic alcoholism, show a marked impairment of lipoprotein lipase. Therefore we influenced blood-pH in 3 healthy subjects by infusions to get alkalotic, neutral and acidotic blood-pH on three days in series. On each day blood-pH from capillary blood and post-heparin lipoprotein lipase from fasting plasma was determined. In comparison to neutral blood-pH in vivo, alkalosis did not influence lipoprotein lipase. In contrast, during artificial acidosis, lipoprotein lipase was impaired significantly (p less than 0.01). Therefore, it seems, that acidosis inhibits lipoprotein lipase in vivo.
D000086:Acetazolamide / Q000008:administration & dosage; D000138:Acidosis / Q000201:enzymology; D000328:Adult; D001639:Bicarbonates / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000008:administration & dosage; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D009088:Mucoproteins; C010393:lysin, gastropoda; D017693:Sodium Bicarbonate; D006493:Heparin; D008071:Lipoprotein Lipase; D000086:Acetazolamide
Aktivitätsverminderung der post-Heparin-Lipoproteinlipase bei azidotischem Blut-pH.