Unusual electron microscopy findings in liver biopsies from patients with viral hepatitis B.
Electron microscopy of 57 needle biopsies from livers of 55 patients with chronic hepatitis, mostly of type B, revealed, in addition to typical hepatitis B virus nucleocapsids in 34 cases, also atypical intranuclear inclusions in 9 biopsies. These inclusions consisted of electron-dense particles similar in size to hepatitis B virus nucleocapsids. The possibility of an involvement of a hepatitis non-A non-B virus is discussed.
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D002213:Capsid / Q000648:ultrastructure; D002467:Cell Nucleus / Q000382:microbiology; D002908:Chronic Disease; D006509:Hepatitis B / Q000382:microbiology*; D006515:Hepatitis B virus / Q000648:ultrastructure*; D006526:Hepatitis C / Q000382:microbiology; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D008099:Liver / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged