title: Salmonella typhi in vivo acquires resistance to both chloramphenicol and co-trimoxazole.
abstract: Salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. Chloramphenicol and sulphonamide resistances were determined by one plasmid, of IncH, whose carriage also changed the Vi phage type. Trimethoprim resistance was determined by a transposon, Tn7, carried in another plasmid, of IncI. The same resistance genes were identified in a strain of klebsiella isolated from the patient.
mesh_terms: D000328:Adult; D002701:Chloramphenicol / Q000494:pharmacology*; D004251:DNA Transposable Elements / Q000187:drug effects; D004338:Drug Combinations / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D010957:Plasmids / Q000187:drug effects; D012485:Salmonella typhi / Q000145:classification / Q000187:drug effects*; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014556:Urine / Q000382:microbiology
chemical_list: D004251:DNA Transposable Elements; D004338:Drug Combinations; D002701:Chloramphenicol; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole