title: GABA neurons in the cat red nucleus: a biochemical and immunohistochemical demonstration.
abstract: Following unilateral kainic acid lesioning of neuronal cell bodies in the cat red nucleus (RN), a large decrease in glutamic acid decarboxylase (GAD) activity was detected in the injected RN, compared to the RN from control, non-injected animals. Using GAD immunohistochemistry, reactive perikarya were visualized dorsolaterally to the rostral part of the nucleus as well as within the RN proper. Taken together, these results point to the existence of an intrinsic GABAergic innervation in the RN area of the cat. The GABAergic neurons characterized here might thus correspond to the inhibitory interneurons previously detected electrophysiologically as a putative source of GABA for large-sized neurons of the RN.
mesh_terms: D000818:Animals; D002415:Cats; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D007395:Interneurons / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology; D009433:Neural Inhibition; D012012:Red Nucleus / Q000378:metabolism* / Q000502:physiology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D007608:Kainic Acid