[Adenosine cyclic-3',5'-monophosphate phosphodiesterase in hepatomas with different growth rates].
The cAMP phosphodiesterase activity in mouse hepatomas 46, 61 and 22A is established to be lower than in the normal liver. Sensitivity of enzymes to inhibitors in tumours is also lower. Dibutyryl-cAMP inhibits the growth of hepatoma 46 and leads to an increase in the functional activity of tumour cells.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000201:enzymology* / Q000473:pathology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013806:Theophylline / Q000494:pharmacology
D003994:Bucladesine; D013806:Theophylline; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Fosfodiésteraza tsiklicheskogo adenozin-3',5'-monofosfata v gepatomakh s razlichnoĭ skorost'iu rosta.