Detection of multiple strains of latent herpes simplex virus type 1 within individual human hosts.
One hundred and fifteen isolates of herpes simplex virus were recovered from parallel explant cultures of trigeminal and vagus ganglia and trigeminal nerve roots derived from 20 unselected human cadavers. Restriction enzyme patterns of strains recovered from 18 of 20 individuals could be differentiated from individual to individual, although all isolates from a single host were identical. Isolates from two individuals differed among themselves in the number and location of certain restriction enzyme sites.
D001483:Base Sequence; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000302:isolation & purification; D005724:Ganglia / Q000382:microbiology*; D005814:Genes, Viral; D006801:Humans; D018139:Simplexvirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D013045:Species Specificity; D014276:Trigeminal Nerve / Q000382:microbiology*; D014630:Vagus Nerve / Q000382:microbiology*
D004279:DNA, Viral; D004262:DNA Restriction Enzymes