title: Regulative action of cyclic AMP and histamine on the immune response mediated by surface receptors of cells.
abstract: The study of the effect of histamine and cAMP on the proliferation of lymphocyte populations has shown that both substances induce a significant decrease in the rate of T-suppressor proliferation. This effect can be neutralized by methiamide--a blocker of H2-histamine receptors. The obtained results point out the possibility of a regulative effect of cAMP on the proliferation of T-suppressors. This effect is mediated by surface receptors of the cell which are similar to or identical with H2-histamine receptors.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D000242:Cyclic AMP / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology*; D008785:Metiamide; D051379:Mice; D008810:Mice, Inbred C57BL; D011738:Pyrilamine / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D006635:Histamine H2 Antagonists; D008785:Metiamide; D006632:Histamine; D000242:Cyclic AMP; D011738:Pyrilamine