Blockade of chlorpropamide alcohol flush by aspirin.
The blocking effects of aspirin, chlorpheniramine, and cimetidine were tested against the flush provoked by alcohol in twenty-four chlorpropamide-treated patients with non-insulin-dependent diabetes mellitus. Active preparations were compared in a double-blind manner with an indistinguishable placebo. Aspirin significantly decreased the number of patients who flushed. Five patients studied in detail all showed suppression of chlorpropamide/alcohol flush by aspirin, with a mean facial temperature increase during the flush of 2.4 degrees C after pretreatment with placebo and an increase of 0.4 degrees C after pretreatment with aspirin.
D001241:Aspirin / Q000494:pharmacology*; D001808:Blood Vessels / Q000187:drug effects; D001831:Body Temperature; D002744:Chlorpheniramine / Q000494:pharmacology*; D002747:Chlorpropamide / Q000494:pharmacology* / Q000627:therapeutic use; D002927:Cimetidine / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000503:physiopathology*; D004311:Double-Blind Method; D000431:Ethanol / Q000494:pharmacology*; D005145:Face / Q000098:blood supply*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D012867:Skin / Q000098:blood supply*
D006146:Guanidines; D000431:Ethanol; D002744:Chlorpheniramine; D002927:Cimetidine; D001241:Aspirin; D002747:Chlorpropamide