The search for H-2 complementation affecting the anti-Thy-1 response in mice: a progress report.
It has been postulated that combinatorial Ia molecules of IAb/Iad heterozygotes are involved in the recognition of the Thy-1 alloantigens. These molecules could be considered the products of the complementary Ir-Thy-1 genes. In present studies, no complementation was found among 37 different H-2 heterozygous F1 hybrids except those carrying IAb/IAd haplotypes. However, in two instances involving hybrids carrying IAr alleles anti-Thy-1 responses were found to be better than expected. The possible mechanism(s) of such responses is currently under investigation.
D000818:Animals; D000917:Antibody Formation; D000954:Antigens, Surface / Q000235:genetics* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D006238:Haploidy; D006579:Heterozygote; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008565:Membrane Proteins / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins; D018800:Thy-1 Antigens