Effects of acute and chronic administration of phencyclidine on tyrosine hydroxylase activity in rat striatum.
Following a single dose of phencyclidine (PCP) striatal tyrosine hydroxylase (TH) activity was decreased 42% 15 min after PCP administration, but returned toward baseline levels by 45 min post-drug. Twenty-four hours after the 30th dose of PCP, TH activity remained depressed when compared to the chronic slaine controls. TH activity was not further depressed 15 or 45 min after the 31st dose of PCP.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D014446:Tyrosine 3-Monooxygenase; D010622:Phencyclidine