[Structural and functional changes in the synaptic membranes of the brain during aging].
Below 37 degrees the mobility of lipids in rat brain synaptic membranes evaluated by the spin probe method is higher in old (24-26 months) than in young (5-6 months) animals. The number of ouabain receptors in membranes increases with age, while maximum rate and Km values are not changed. The relation between structural state of membrane and properties of ouabain binding centers is discussed.
D000375:Aging; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013113:Spin Labels; D013570:Synaptic Membranes / Q000201:enzymology / Q000378:metabolism*; D013696:Temperature
D008051:Lipid Bilayers; D011955:Receptors, Drug; D013113:Spin Labels; C028996:cardiac glycoside receptors; D000254:Sodium-Potassium-Exchanging ATPase
Strukturno-funktsional'nye izmeneniia sinapticheskikh membran mozga pri starenii.