Effect of a beta-adrenergic agonist, fenoterol, on nasal sensitivity to allergen.
Fenoterol hydrobromide, 1 mg/ml, was given by nasal spray in doses between 204 and 576 microgram in an attempt to reduce nasal sensitivity to Lolium perenne allergen in a nasal provocation test during a 2-hr period following the drug. In a randomized double-blind comparison between fenoterol and placebo in 11 patients, reduction of nasal sensitivity be fenoterol was small but significant in a one-tailed test (p = 0.03). In the 15 min following the fenoterol spray the increase in the average nasal airway resistance (NAR) was significantly higher than the increase in NAR after placebo (p = 0.026), suggesting that fenoterol may also act as a vasodilator in the nose. This effect is consistent with findings by other investigators who showed that isoproterenol also increased nasal airways resistance.
D000318:Adrenergic beta-Agonists; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D000485:Allergens; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009299:Nasal Provocation Tests; D010366:Peak Expiratory Flow Rate; D010919:Placebos; D011674:Pulse / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D000485:Allergens; D004983:Ethanolamines; D010919:Placebos; D005280:Fenoterol