Neural control of gene expression in the skeletal muscle fibre: changes in the muscular mRNA population following denervation.
The mRNA populations of control and 8-days-denervated adult rat gastrocnemius have been analysed by the translation assay and the cDNA-mRNA molecular hybridization technique. This analysis demonstrates the appearance of marked changes in many of the mRNA sequences present in muscle fibres following denervation and thus gives strong support to the hypothesis that the motoneurons are able to control the gene expression of muscle fibres.
D000818:Animals; D003714:Denervation; D005786:Gene Expression Regulation; D005813:Genes, Synthetic; D008297:Male; D009046:Motor Neurons / Q000502:physiology*; D009124:Muscle Proteins / Q000032:analysis; D009132:Muscles / Q000294:innervation / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats
D009124:Muscle Proteins; D012333:RNA, Messenger