gamma-Glutamylamine cyclotransferase: specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds.
gamma-Glutamylamine cyclotransferase, an enzyme that catalyzes the conversion of L-gamma-glutamylamines to free amines and 5-oxo-L-proline, was found in rabbit kidney and in various other tissues. The specificity of this enzyme indicates that it functions in the metabolism of products of transglutaminase action; among its substrates are epsilon-(L-gamma-glutamyl)-L-lysine, a derivative of this peptide in which the alpha-amino and carboxyl groups of the lysine moiety are blocked, and L-gamma-glutamyl-polyamine derivatives.
D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D004151:Dipeptides / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D007668:Kidney / Q000201:enzymology*; D011817:Rabbits; D013379:Substrate Specificity; D014018:Tissue Distribution; D005722:gamma-Glutamylcyclotransferase / Q000378:metabolism*
D004151:Dipeptides; D000217:Acyltransferases; D005722:gamma-Glutamylcyclotransferase; D006909:Hydroxyproline