T cell growth factors from adult T cell leukemia virus-transformed cell lines.
Some characteristics of T cell growth factors derived from adult T cell leukemia virus (ATLV)-transformed cell lines, MT 1 and MT 2 were analyzed. MT 1 cells release significant interleukin 2 (IL 2) activity into the culture medium, which showed the same elution pattern of gel filtration and isoelectric focusing of IL 2 from lectin-stimulated normal human lymphocytes. This activity was also detected in the cell extract of MT 1. In contrast, MT 2 cell line did not produce IL 2 activity, but non-IL 2 type growth factor was observed. The significance of these factors from MT cell lines is discussed from the viewpoint of 'autokine' in ATLV-transformed cells.
D000328:Adult; D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D003208:Concanavalin A; D004261:DNA Replication; D017977:Deltaretrovirus / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000302:isolation & purification*; D007938:Leukemia / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology
D007376:Interleukin-2; D003208:Concanavalin A