title: Cross-species extrapolation in hydrocarbon neuropathy.
abstract: Not all species demonstrate the same vulnerability to hydrocarbon neuropathy. These differences are related to axonal length and diameter as well as to variations in toxicokinetics. While cross-species extrapolation is made difficult by these factors, understanding the basis for the differences provides insight into pathogenesis.
mesh_terms: D000818:Animals; D001369:Axons; D002645:Chickens; D003599:Cytoskeleton / Q000187:drug effects; D004198:Disease Susceptibility; D006586:Hexanes / Q000633:toxicity; D006588:Hexanones / Q000633:toxicity; D006801:Humans; D006838:Hydrocarbons / Q000633:toxicity*; D051379:Mice; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D051381:Rats; D013045:Species Specificity
chemical_list: D006586:Hexanes; D006588:Hexanones; D006838:Hydrocarbons; C039195:3,4-dimethyl-2,5-hexanedione; C026385:n-hexane; C011269:2,5-hexanedione