The action of somatostatin on intestinal alkaline phosphatase stimulated by secretin and cholecystokinin-pancreozymin.
The action of somatostatin on intestinal alkaline phosphatase activity (IAP) in the duodenal juice was examined in 22 subjects undergoing diagnostic secretin-CCK-PZ-tests. Under continuous secretin-CCK-PZ-stimulation there is an increase of IAP which is followed by a period of exhaustion after 1 h of stimulation. The intravenous administration of somatostatin induces a distinct inhibition of IAP which cannot be due to the exhaustion of the enzyme synthesis. As there is a functional relationship between fat absorption and alkaline phosphatase, it is suggested that this inhibition of IAP is one of the mechanisms of the somatostatin-induced inhibition of intestinal fat absorption.
D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism*; D002766:Cholecystokinin; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D006801:Humans; D007419:Intestinal Secretions / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D012633:Secretin; D013004:Somatostatin / Q000494:pharmacology*
D012633:Secretin; D013004:Somatostatin; D002766:Cholecystokinin; D000469:Alkaline Phosphatase