Central-type benzodiazepine binding sites in rat pituitary gland are of the BZ1 subtype.
Experiments were performed to investigate the subtype of central-type benzodiazepine binding site present in rat pituitary gland. Bmax values for [3H] n-propyl beta-carboline-3-carboxylate and [3H] flunitrazepam (for central-type binding only) were similar. Displacement of [3H] flunitrazepam by n-propyl beta-carboline-3-carboxylate gave a linear Hofstee plot and a Hill coefficient close to unity. These results suggest that the central benzodiazepine binding sites in the pituitary are predominantly of the BZ1 subtype, as found in the cerebellum.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002243:Carbolines / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*
D002243:Carbolines; D011963:Receptors, GABA-A; D005445:Flunitrazepam; C028585:propyl beta-carboline-3-carboxylate