A biochemical comparison of alclofenac and D-penicillamine in rheumatoid arthritis.
In view of the claim that alclofenac has a specific antirheumatoid action a detailed biochemical study has been made over a 6-month period of 2 groups of patients with rheumatoid arthritis receiving either alclofenac or D-penicillamine for the first time. We found no biochemical evidence and little clinical evidence that alclofenac had a 'penicillamine-like' effect in rheumatoid arthritis.
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D001799:Blood Sedimentation; D001809:Blood Viscosity; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D010396:Penicillamine / Q000627:therapeutic use*; D010648:Phenylacetates / Q000627:therapeutic use*; D013438:Sulfhydryl Compounds / Q000097:blood
D010648:Phenylacetates; D013438:Sulfhydryl Compounds; D002097:C-Reactive Protein; D010396:Penicillamine