title: The effect of bendroflumethiazide and hydrochlorothiazide on the rate of dissolution of calcium hydroxyapatite.
abstract: Inhibition of dissolution of calcium hydroxyapatite in the presence of bendroflumethiazide, Centyl, and of hydrochlorothiazide has been investigated. The former compound has a pronounced larger inhibitory effect than the latter. The trifluormethyl group in bendroflumethiazide has been shown to hydrolyze, with the release of fluoride and hydrogen ions, presumably forming a carboxylic acid. The inhibitory effect of hydrolyzed bendroflumethiazide is found to be similar to the effect of a potassium fluoride solution with the same fluoride ion concentration, as measured by a fluoride selective ion electrode.
mesh_terms: D001539:Bendroflumethiazide / Q000494:pharmacology; D001862:Bone Resorption / Q000187:drug effects; D017886:Durapatite; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006868:Hydrolysis; D006882:Hydroxyapatites
chemical_list: D006882:Hydroxyapatites; D006852:Hydrochlorothiazide; D001539:Bendroflumethiazide; D017886:Durapatite