title: Effects of various pharmacologic agents on allergic inflammation of the eye. The roles of chemical mediators in ocular inflammation.
abstract: Effects of pharmacologic agents on experimental ocular inflammation induced by reverse passive Arthus reactions were investigated by a slit-lamp technique utilizing fluorescein-labeled rabbet serum albumin as an indicator. Cobra venom factor completely eliminated inflammatory responses, indicating that the complement system is a trigger for this type of ocular inflammation. Antihistamines mainly suppressed the early vascular response. Reserpine and indomethacin remarkably inhibited the increase of the permeability of the blood-aqueous barrier over the first 5 hr. Epinephrine and steroid hormone were also effective. Neither diethylcarbamazine nor isonicotinic acid showed effects on the permeability changes induced in this type of inflammation.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000937:Antigen-Antibody Reactions; D001082:Aqueous Humor / Q000187:drug effects / Q000502:physiology; D001183:Arthus Reaction / Q000188:drug therapy*; D004195:Disease Models, Animal; D004546:Elapid Venoms / Q000627:therapeutic use; D005128:Eye Diseases / Q000188:drug therapy*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D011817:Rabbits; D012110:Reserpine / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D004546:Elapid Venoms; D006634:Histamine H1 Antagonists; D012110:Reserpine; D007213:Indomethacin