Inhibitory effects of a new antiallergic agent, azelastine, on passive cutaneous anaphylaxis and expulsion of Nippostrongylus brasiliensis.
A new antiallergic agent, 4-(p-chlorobenzyl)-2-[N-methyl-perhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride (azelastine), was found to exert inhibitory effects on passive cutaneous anaphylaxis in the rat and on expulsion of Nippostrongylus brasiliensis from the rat intestine when this agent was administered intravenously at appropriate doses.
D000818:Animals; D002974:Clemastine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007073:Immunoglobulin E / Q000494:pharmacology; D008297:Male; D009349:Nematode Infections / Q000276:immunology*; D009559:Nippostrongylus; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010793:Phthalazines / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats
D006634:Histamine H1 Antagonists; D010793:Phthalazines; D011724:Pyridazines; D007073:Immunoglobulin E; D002974:Clemastine; C020976:azelastine