Danger of withdrawal of vasodilator therapy in patients with chronic heart-failure.
Ten patients with severe congestive heart-failure were treated with a vasodilator, prazosin, in addition to diuretics; their exercise capacity was assessed by testing on a treadmill. After the withdrawal of prazosin the condition of three patients deteriorated markedly.
D000208:Acute Disease; D000368:Aged; D004334:Drug Administration Schedule; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006334:Heart Function Tests; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000008:administration & dosage* / Q000627:therapeutic use; D011799:Quinazolines / Q000008:administration & dosage*
D011799:Quinazolines; D011224:Prazosin