title: Dexamethasone inhibits the production of thromboxane B2 and leukotriene B4 by human alveolar and peritoneal macrophages in culture.
abstract: Cultured human alveolar and peritoneal macrophages have been shown to release thromboxane B2 and leukotriene B4. The release was facilitated by stimulation of the macrophages with opsonized zymosan A (1.2 mg/ml). The release was inhibited in a concentration-dependent manner by incubation of the cells with dexamethasone (1 nmol/l to 1 mumol/l).
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D001201:Ascites / Q000473:pathology; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D007975:Leukotriene B4 / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000166:cytology; D013929:Thromboxane B2 / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism*; D015054:Zymosan / Q000494:pharmacology
chemical_list: D013931:Thromboxanes; D007975:Leukotriene B4; D013929:Thromboxane B2; D003907:Dexamethasone; D015054:Zymosan; D000118:Acetylglucosaminidase