Autoradiographic evidence for binding of 3H-flunitrazepam (Rohypnol) to melanin granules in the cat eye.
This autoradiographic study revealed after an i.,v. injection an accumulation of 3H-flunitrazepam in melanin granules of the pigment epithelium and of the choroid cells. It seems that after a short period, a large proportion of the strongly bound drug is released.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001345:Autoradiography; D001665:Binding Sites; D002415:Cats; D003594:Cytoplasmic Granules / Q000378:metabolism*; D005445:Flunitrazepam / Q000378:metabolism*; D007700:Kinetics; D008543:Melanins / Q000378:metabolism*; D012160:Retina / Q000378:metabolism*; D014316:Tritium
D014151:Anti-Anxiety Agents; D008543:Melanins; D014316:Tritium; D005445:Flunitrazepam