title: Intrathecal human tetanus immunoglobulin in early tetanus.
abstract: 97 patients with symptoms of early tetanus at the time of admission to hospital were treated with sedation, antibiotics, and human tetanus immune globulin (TIG). After intrathecal TIG 250 IU 3 patients out of 49 got worse but only 1 died while in a closely similar group of 48 patients in whom TIG was administered intramuscularly in dose of 1000 IU, the clinical features of the disease became severer in 15 (31%) and 10 (21%) died. The intrathecal use of TIG was devoid of side effects.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D013742:Tetanus / Q000628:therapy*; D013743:Tetanus Antitoxin / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D007136:Immunoglobulins; D013743:Tetanus Antitoxin