[Comparative evaluation of dysplasia and early cancer of the stomach based on analysis of DNA content].
DNA content in the tumour cell nuclei was studied in 16 cases of early stomach carcinoma and in the adjacent areas of the foveolar epithelium dysplasia and metaplastic intestinal epithelium. One wave microspectrophotometry was used; the slides were stained with gallocyanin-chrome alum. The number of DNA synthesizing diploid cells was increasing with the increase of the dysplasia degree. The number of tetraploid cells was higher and the signs of aneuploidy appeared in the areas of noninvasive carcinoma. The stem line in early invasive carcinoma was represented by the diploid cells. The increase of cell atypia in tubular and papillary adenocarcinoma is followed by increase of the tetraploid cell number and by the appearance of polyploidy and aneuploidy. Both undifferentiated and goblet-cell carcinomas have similar parameters of the DNA histogram. DNA content allows an objective judgement on the degree of an early carcinoma cell atypia and differentiation of the advanced dysplasia and noninvasive carcinoma.
D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000032:analysis / Q000473:pathology*; D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000032:analysis / Q000473:pathology*; D013274:Stomach Neoplasms / Q000032:analysis / Q000473:pathology*
D004273:DNA, Neoplasm
Sravnitel'naia otsenka displazii i rannego raka zheludka po dannym opredeleniia soderzhaniia DNK.