Actions of the optical isomers of 2-amino-5-phosphonovalerate as antagonists of excitatory amino acids.
Both D(-)-and L(+)-2-amino-5-phosphonovaleric acid (APV) antagonize amino acid-induced excitations of mammalian spinal neurones and are qualitatively indistinguishable from D-alpha-aminoadipate in this respect. L(+)-APV however has a slower onset of action possibly suggesting that its affinity for the receptor is lower.
D015763:2-Amino-5-phosphonovalerate; D000200:Action Potentials / Q000187:drug effects; D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000818:Animals; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D013116:Spinal Cord / Q000166:cytology; D013237:Stereoisomerism; D014633:Valine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000596:Amino Acids; D015763:2-Amino-5-phosphonovalerate; D014633:Valine