Influence of combined application of orotic acid and central stimulants on memory processes and participation of cholinergic mechanisms.
Experiments on albino rats trained and tested for memory in a maze have shown the following. Orotic acid (100 mg/kg) does not influence learning, but it improves retention. On the background of orotic acid the central stimulants caffeine, strychnine and amphetamine do not change their learning-facilitating effect. Combined application of orotic acid and stimulants, however, has a stronger effect on retention than their independent application. The increased retention-improving effect of the combination of orotic acid and central stimulants disappears after blocking of the central M-cholinergic structures with atropine. The results obtained are interpreted in the light of the views of the role of the excitation level after training for the course of the biosynthetic processes in the memory-facilitating effect of the central stimulants.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D008568:Memory / Q000187:drug effects*; D009963:Orotic Acid / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013331:Strychnine / Q000494:pharmacology
D000697:Central Nervous System Stimulants; D002110:Caffeine; D009963:Orotic Acid; D001285:Atropine; D000661:Amphetamine; D013331:Strychnine