Species differences in clobazam metabolism and antileptazol effect.
The antileptazol effect of clobazam lasts longer in the mouse than in the rat. After intraperitoneal injection of clobazam (10 mg kg-1) plasma and brain concentrations of the drug and its rate of disappearance were similar in both species, whereas the metabolite N-demethylclobazam was present at higher concentrations and for longer in the mouse than in the rat. Although the exact contribution of the N-desmethylclobazam to the anticonvulsant effect of clobazam cannot be assessed, the longer duration in mice than in rats seems to be associated with different brain accumulations of the metabolite.
D000818:Animals; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D000078306:Clobazam; D003640:Dealkylation; D006207:Half-Life; D007700:Kinetics; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000078306:Clobazam; D010433:Pentylenetetrazole