Inhibition by ketotifen of idiosyncratic reactions to aspirin.
Ketotifen administered prior to aspirin offered protection against bronchoconstriction in 13 of 14 patients with aspirin-sensitive asthma. In four other subjects, suffering from urticaria/angioedema following ingestion of aspirin-like drugs, pretreatment with ketotifen resulted in total prevention of the adverse reactions. These results support the suggestion of a common pathogenetic mechanism operating in two distinct clinical patterns of idiosyncrasy to aspirin and other cyclo-oxygenase inhibitors. They also indicate that ketotifen might find application in treatment of adverse reactions to aspirin.
D000328:Adult; D001241:Aspirin / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D001249:Asthma / Q000139:chemically induced / Q000517:prevention & control*; D001980:Bronchi / Q000187:drug effects; D001986:Bronchial Spasm / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000517:prevention & control; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006801:Humans; D007665:Ketotifen; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000494:pharmacology*; D010919:Placebos; D013876:Thiophenes / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D010880:Piperidines; D010919:Placebos; D013876:Thiophenes; D001241:Aspirin; D007665:Ketotifen