Electrophysiological evidence that local anesthetics and antiarrhythmic drugs bind to a specific receptor site in cardiac sodium channels: displacement of bupivacaine by lidocaine.
D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D001667:Binding, Competitive; D002045:Bupivacaine / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008012:Lidocaine / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D008012:Lidocaine; D012964:Sodium; D002045:Bupivacaine