[Pathogenetic therapy of cobalt-induced cardiomyopathies].
The pathogenesis of damage to the heart muscle caused by exposure to the effect of cobalt compounds is demonstrated. Agents with various mechanisms of action were tested in the experiment. The most effective pharmacological agents (beta-adrenergic blocking agents, anabolic steroids) are recommended for testing in the clinic. A positive effect was registered in the treatment of cobalt cardiomyopathy in the clinic. The mechanisms of the favourable effect of beta-adrenergic blocking agents and anabolic steroids are discussed.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D045930:Anabolic Agents / Q000627:therapeutic use; D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000188:drug therapy*; D003035:Cobalt / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D009526:Nialamide / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D013386:Succinates / Q000627:therapeutic use; D013438:Sulfhydryl Compounds / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D045930:Anabolic Agents; D013386:Succinates; D013438:Sulfhydryl Compounds; D003035:Cobalt; D007980:Levodopa; D009277:Nandrolone; D011433:Propranolol; D000077603:Nandrolone Decanoate; D009526:Nialamide
Patogeneticheskaia terapiia kobal'tovykh kardiomiopatiĭ.