[Demonstration of experimental disinhibitory activity in a series of neuroleptic orthoanisamides].
Among 3 orthoanisamides having different substitution of the nitrogen of a pyrrolidine ring, derivates ethyl (sulpiride) and propyl GRI 1665) show desinhibitory properties by the test of behavioural despair of Porsolt and coll, while the methyl derivative (TER 1546) is inactive.
D000818:Animals; D000928:Antidepressive Agents; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D001549:Benzamides
Mise en évidence d'une activité désinhibitrice expérimentale dans une série d'orthoanisamides neuroleptiques.