Detection of antibodies to human T-lymphotropic viruses type I and III in Japanese hemophiliacs.
Sera of 65 hemophiliacs, 85 hemodialysis patients and 304 healthy volunteer blood donors in Japan were tested for antibodies against both HTLV-I and -III by an indirect immunofluorescence and radioimmunoprecipitation assay. The results showed that 10 (15.4%) of the hemophiliacs were anti-HTLV-III positive, while all other subjects were anti-HTLV-III negative. All groups contained subjects positive for anti-HTLV-I. The prevalence of the antibody in the hemophiliacs (17.4%) and hemodialysis patients (9.4%) was significantly high as compared to that of healthy controls (1%).
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D017977:Deltaretrovirus / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006467:Hemophilia A / Q000276:immunology*; D006801:Humans; D007564:Japan; D008875:Middle Aged; D011233:Precipitin Tests; D006435:Renal Dialysis
D000914:Antibodies, Viral