Prospective study of liver function following repeat halothane and enflurane.
In a prospective study of liver function following repeat anaesthesia, patients who received repeat halothane had a higher frequency of abnormal liver enzyme results than a similar group who received repeat enflurane. Obesity and short intervals between administrations increased the likelihood of abnormal liver enzyme activity in the halothane group. Enflurane would seem to be the volatile agent of choice for repeat anaesthesia in such circumstances.
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D004737:Enflurane / Q000009:adverse effects*; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D005723:gamma-Glutamyltransferase / Q000097:blood
D004737:Enflurane; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D006221:Halothane