Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000097:blood; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000097:blood; D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D001792:Blood Platelets / Q000201:enzymology; D005260:Female; D006162:Guanylate Cyclase / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008981:Molsidomine; D009025:Morpholines / Q000378:metabolism / Q000494:pharmacology*; D010069:Oxadiazoles / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013558:Sydnones / Q000378:metabolism / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects
D009025:Morpholines; D010069:Oxadiazoles; D013558:Sydnones; D008981:Molsidomine; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D006162:Guanylate Cyclase