The role of the renin-angiotensin system in blood pressure regulation in normotensive animals and man.
The role of the renin-angiotensin system in the control of blood pressure in normal rodents, primates and man has been evaluated using inhibitors which block the system at various stages. Renin plays a major role in the maintenance of blood pressure under volume depletion. In subjects with a normal salt intake, the contribution of the renin-angiotensin system in maintaining blood pressure levels can be evaluated using angiotensin converting enzyme (ACE) inhibitors. The contribution of the renin-angiotensin system can now be evaluated more closely following the development of new substances which block the renin-angiotensinogen reaction. Available data strongly suggest that renin contributes to the maintenance of blood pressure levels in subjects with a normal salt intake, although to a lesser degree than in subjects on a low sodium intake. The renin-angiotensin system plays a role in the regulation of blood pressure levels in normal experimental animals and man--its importance depending on the state of sodium balance.
D000804:Angiotensin II / Q000037:antagonists & inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume; D002144:Callithrix; D002216:Captopril / Q000494:pharmacology; D004173:Dipodomys; D004656:Enalapril / Q000494:pharmacology; D006706:Homeostasis; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000187:drug effects; D012964:Sodium / Q000502:physiology; D000092502:Renin Inhibitors
D000804:Angiotensin II; D002216:Captopril; D004656:Enalapril; D012083:Renin; D012964:Sodium; D000092502:Renin Inhibitors