Excretion of cyclic 3',5'-adenosine monophosphate in the early newborn period.
The relationship between cyclic 3',5'-adenosine monophosphate (cAMP) excretion and creatinine clearance, urinary phosphate excretion, and urinary osmolarity was studied under basal conditions in 29 babies of 28-40 weeks gestation, during the first few days of life. Urinary cAMP excretion was directly related to creatinine clearance, r = 0.89, P less than 0.001, and gestational age, r = 0.63, P less than 0.001. There was no relationship between urinary cAMP excretion and urinary phosphate excretion or urine osmolarity. These results indicate that urinary cAMP excretion is dependent on the rate of glomerular filtration and gestational age.
D000242:Cyclic AMP / Q000652:urine*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D009994:Osmolar Concentration; D010710:Phosphates / Q000652:urine
D010710:Phosphates; D000242:Cyclic AMP