Synthesis and protective effects of poly-8-bromoriboadenylic acid: poly ribouridylic acid hybrid against Wesselsbron virus in chick embryos.
Poly-8-bromoriboadenylic acid was synthesized by the bromination of adenosine-5'-monophosphate to yield 8-bromoadenosine-5'-monophosphate which on conversion to the 5'-diphosphate form was polymerized by polynucleotide phosphorylase (PNPase). The polymer formed a 1:1 hybrid with polyribouridylic acid and the hybrid was found to protect chick embryos against Wesselsbron virus (H10964).
D000818:Animals; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D007202:Indicators and Reagents; D011061:Poly A / Q000138:chemical synthesis* / Q000494:pharmacology; D011201:Poultry Diseases / Q000188:drug therapy / Q000382:microbiology*; D014036:Togaviridae Infections / Q000188:drug therapy / Q000662:veterinary*
D007202:Indicators and Reagents; D011061:Poly A; C015463:poly 8-bromoadenylic acid