Solid phase synthesis of retro-inverso peptide analogues. Synthesis and biological activity of the partially modified retro-inverso analogue of the bradykinin potentiating peptide BPP9a [gLys6, (RS)-mPhe7, Ala8] BPP9a.
The solid phase synthesis of a partially modified retro-inverso analogue of the bradykinin potentiating peptide BPP9a, [gLys6, (R,S)-mPhe7, Ala8] BPP9a is described. The analogue, which is active in vitro and in vivo, displays prolonged resistance towards cleavage by angiotensin converting enzyme (ACE).
D001681:Biological Assay; D001920:Bradykinin / Q000031:analogs & derivatives*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000378:metabolism; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D013329:Structure-Activity Relationship
D009842:Oligopeptides; C006791:bradykinin potentiating factors; D007703:Peptidyl-Dipeptidase A; D001920:Bradykinin