Sodium, potassium, and metabolic studies of glial, liver, and kidney nuclei under anoxic-ischemic conditions.
Glial, liver, and kidney nuclei were studied under anoxic-ischemic conditions. It was found that glial nuclei were significantly depleted of sodium and potassium as early as 15 seconds after the insult, whereas liver and kidney nuclei were not. There was a concomitant significant drop in high-energy substrates (ATP, P-creatine, glucose) in both glial and brain homogenate, whereas these substrates remained relatively constant in kidney and began to drop only at the four-minute time point in liver. These unique observations in glial nuclei may have important implications in the glial swelling that is seen in ischemic states.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D002534:Hypoxia, Brain / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D009457:Neuroglia / Q000378:metabolism*; D009928:Organ Specificity; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D011188:Potassium