Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers.
Microinjection of L-glutamate into the intermediate nucleus tractus solitarii in anesthetized rats elicits hypotension, bradycardia, and apnea, simulating baroreceptor reflexes. Ablation of the nodose ganglion results in selective reduction of high-affinity uptake of L-glutanate in the nucleus tractus solitarii. L-Glutamate may be the neurotransmitter of afferent nerve fibers from arterial baroreceptors.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001931:Brain Mapping; D005971:Glutamates / Q000494:pharmacology / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D007608:Kainic Acid / Q000494:pharmacology; D008526:Medulla Oblongata / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D012018:Reflex / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D005971:Glutamates; D018377:Neurotransmitter Agents; D007608:Kainic Acid