Multiple beta cell neoplasms in a polar bear: an immunohistochemical study.
A 25-year-old polar bear had multiple pancreatic islet cell adenomas and carcinomas. Special staining and immunohistochemical techniques showed the neoplasms to be of beta cell origin. An association between excessive carbohydrate diet and the multiple beta cell neoplasms is suggested.
D001078:APUD Cells / Q000166:cytology; D007516:Adenoma, Islet Cell / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002335:Carnivora; D005455:Fluorescent Antibody Technique; D006946:Hyperinsulinism / Q000473:pathology / Q000662:veterinary; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000662:veterinary*; D001503:Ursidae