title: [Metabolic shifts during the repeated administration of analeptics in alcoholic intoxication].
abstract: It was shown in experiments on rabbits that under acute alcohol poisoning of medium degree, repeated administration of caffeine (10 mg/kg) and bemegrid in particular (5 mg/kg) promotes aerobization of the oxidative processes and mobilizes the respiratory mechanism of metabolic acidosis compensation. Under these conditions, ethimizol (10 mg/kg) stimulates the respiratory center and promotes (to a less measure) aerobization of the metabolic processes in tissues and ethanol elimination.
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D001534:Bemegride / Q000008:administration & dosage; D002110:Caffeine / Q000008:administration & dosage; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000378:metabolism; D005042:Etimizol / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011817:Rabbits; D013997:Time Factors
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine; D000431:Ethanol; D001534:Bemegride; D005042:Etimizol
vernacular_title: Metabolicheskie sdvigi pri povtornom vvedenii analeptikov v usloviiakh alkogol'noĭ intoksikatsii.