title: Diazepam and lorazepam compared as sedatives for outpatient third molar surgery.
abstract: A clinical trial was designed to compare diazepam and lorazepam when administered intravenously immediately prior to third molar surgery. The two drugs were compared on three scores, patient behaviour during surgery, presence of amnesia and extent of psychomotor impairment. Within the confines of the investigation the principle difference between diazepam and lorazepam was the greater degree of psychomotor impairment induced by the latter drug two hours post-injection.
mesh_terms: D000293:Adolescent; D000328:Adult; D000647:Amnesia / Q000139:chemically induced; D000766:Anesthesia, Dental; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008140:Lorazepam / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008963:Molar / Q000601:surgery; D009043:Motor Activity / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D014095:Tooth, Impacted / Q000601:surgery*
chemical_list: D014151:Anti-Anxiety Agents; D008140:Lorazepam; D003975:Diazepam