Na-K-ATPase in single nephron segments of hypertension-prone rats.
The activity of renal Na-K-ATPase was compared in hypertension-prone (SBH) and hypertension-resistant (SBN) Sabra rats on regular sodium intake and 2-3 weeks after a high sodium diet. ATPase activity was determined in single nephron segments by a micromethod. The activity profile was found to be similar in the two substrains on both regimens. Following high sodium intake there was a significant increment of Na-K-ATPase activity which was limited to the medullary thick ascending limb in the two substrains. The results clearly indicate a lack of relationship between renal Na-K-ATPase activity and proneness or resistance to hypertension in this experimental model.
D000818:Animals; D006973:Hypertension / Q000201:enzymology*; D008297:Male; D009399:Nephrons / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000008:administration & dosage; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis*
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase