Monoclonal antibody specific for human T acute lymphoblastic leukaemia.
A cytotoxic mouse monoclonal antibody (CALL2) was produced against a cultured T acute lymphocytic leukaemia (T ALL) cell line 8402. Ascites fluid containing the antibody was cytotoxic to a titre of up to 1:100 000 against 4 of 6 cultured T ALL cell lines and against leukaemia cells from 7 of 8 T ALL patients and 1 of 5 T chronic lymphatic leukaemia patients. The antibody did not react with normal peripheral-blood T and B lymphocytes, monocytes, granulocytes, spleen cells, thymocytes, platelets, and other acute and chronic leukaemia cells. The CALL2 antibody did not react with bone marrow stem cells of the myeloid series (CFU-C). This antibody may be useful for passive immunotherapy trials since it does not react with normal cells and is highly cytotoxic to T ALL cells.
D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000276:immunology; D000918:Antibody Specificity; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal