Establishment and characterization of adult T-cell leukemia virus-containing B-cell lines derived from peripheral blood of adult T-cell leukemia patients.
B-cell lines which showed predominantly surface IgA kappa immunoglobulins were established from each of seven adult T-cell leukemia (ATL) patients. ATL virus proviral DNA was found in five of the lines. Though the chromosomal analysis of the B-cell lines yielded normal results, fresh leukemic T-cells showed chromosome abnormalities.
D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000382:microbiology*; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D012190:Retroviridae / Q000235:genetics / Q000302:isolation & purification*; D013601:T-Lymphocytes
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D004279:DNA, Viral