Autoradiographic localization of opioid receptors in the rat stomach.
The distribution of opioid receptors in the stomach has been studied using autoradiography of slide-mounted tissue sections incubated with [3H]D-Ala2,D-Leu5-enkephalin. The major sites of binding were the mucosa and the submucosal and deep muscular plexi. Other regions did not exhibit significant binding. These locations suggest that endogenous delta-opioid receptors may regulate mucosal ion transport and smooth muscle motility in the stomach.
D000818:Animals; D001345:Autoradiography; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000378:metabolism; D016308:Enkephalin, Leucine-2-Alanine; D005753:Gastric Mucosa / Q000378:metabolism*; D009197:Myenteric Plexus / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism*; D013368:Submucous Plexus / Q000378:metabolism
D011957:Receptors, Opioid; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine