[A new HTLV retrovirus associated with human T-cell leukemia/lymphoma].
The data concerning retrovirus HTLV isolated from patients with T-cell leukemia/lymphoma are presented. The virus differs from the known C type viruses, possesses high tropism to T-lymphocytes. The virus is exogenous for human cells and its origin is still unknown. Virus specific nucleotide sequences are absent in a normal cell genome, but they are detected in blood cells and tissues of patients with this form of leukemia. HTLV-associated disease is rare and distributed mainly in two regions in the world: in the South-West of Japan and in the Caribbean islands. Mode of the virus transmission is probably horizontal.
D000818:Animals; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D002460:Cell Line; D002472:Cell Transformation, Viral; D004279:DNA, Viral / Q000235:genetics; D017977:Deltaretrovirus / Q000235:genetics* / Q000276:immunology; D005814:Genes, Viral; D006801:Humans; D007564:Japan; D007938:Leukemia / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D008253:Macaca mulatta; D051379:Mice; D009857:Oncogenes; D012192:Retroviridae Infections / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology*; D013601:T-Lymphocytes / Q000382:microbiology; D014764:Viral Proteins / Q000032:analysis; D014900:West Indies
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral; D014764:Viral Proteins
Novyĭ retrovirus HTLV, assotsiirovannyĭ s T-kletochnym leĭkozom/limfomoĭ cheloveka.