Neonatal tolerance of H-2 alloantigens. I. I region modulation of tolerance potential of K and D antigens.
By utilizing H-2 congenic strains of mice and appropriate recombinants, it has been possible to determine that Class I alloantigens (of K and D region genes) function poorly as tolerogens when inoculated into neonatal recipients. Alternatively, Class II alloantigens (encoded by I region genes) are excellent tolerogens. Moreover, Class I alloantigens are converted to good tolerogens when conjoined in the tolerizing inoculum with Class II alloantigens. The I subregions in which genes reside that mediate this tolerance-promoting effect are IJ and/or IE. It is suggested that elicitation of a suppressor mechanism, perhaps related to IJ region alloantigens, is responsible.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D006085:Graft Survival; D006183:H-2 Antigens / Q000235:genetics*; D007108:Immune Tolerance; D007519:Isoantigens / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology*; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D006183:H-2 Antigens; D007519:Isoantigens