Reticuloendotheliosis virus and disturbance in immune regulation.
Reticuloendotheliosis virus (REV-T) is a replication-defective retrovirus which induces a rapidly-fatal lymphoma. The helper virus, reticuloendotheliosis-associated virus (REV-A), induces a splenic suppressor cell population which cytostatically inhibits the proliferation of cytotoxic cells capable of lysing REV-T tumour cells.
D000818:Animals; D001717:Birds; D003602:Cytotoxicity, Immunologic; D006378:Helper Viruses / Q000235:genetics / Q000276:immunology; D007108:Immune Tolerance; D001356:Reticuloendotheliosis virus / Q000235:genetics / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology*