Interferon aerosol suppression of vesicular stomatitis virus replication in the lungs of infected mice.
Mice were inoculated intranasally with vesicular stomatitis virus 16 to 22 h after being exposed to small-particle aerosols of saline, natural mouse alpha interferon, recombinant human alpha interferon A, or hybrid recombinant human alpha interferon A/D bgl for 2, 4, or 8 h. Compared with comparably inoculated, untreated mice, significantly reduced levels of vesicular stomatitis virus were observed in the lungs of animals treated with any interferon preparation for 8 h and in groups treated with mouse alpha interferon or hybrid recombinant human alpha interferon A/D bgl for 4 h. No significant reductions in lung virus titers were observed in any group treated with interferon for 2 h or in any of the groups treated with saline.
D000336:Aerosols; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007370:Interferon Type I / Q000032:analysis / Q000494:pharmacology*; D008168:Lung / Q000032:analysis / Q000382:microbiology*; D008297:Male; D051379:Mice; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
D000336:Aerosols; D007370:Interferon Type I