In vitro bactericidal synergy of gentamicin combined with penicillin G, vancomycin, or cefotaxime against group G streptococci.
The in vitro bactericidal interactions of penicillin G, cefotaxime, or vancomycin in combination with gentamicin were compared against 20 group G streptococci by the timed kill curve method. Synergy was noted at the following frequencies: penicillin plus gentamicin, 80%; cefotaxime plus gentamicin, 85%; vancomycin plus gentamicin, 90%. There was no bactericidal antagonism observed.
D002439:Cefotaxime / Q000494:pharmacology*; D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects*; D013997:Time Factors; D014640:Vancomycin / Q000494:pharmacology*
D005839:Gentamicins; D014640:Vancomycin; D002439:Cefotaxime; D010400:Penicillin G