Mutagenic epoxide impurities discovered in two new beta-adrenergic blocking agents.
Preparations of two new beta-adrenergic blocking drugs, Zami 1305 [1-(2-nitro-3-methyl-phenoxy)-3-tert-butylaminopropan-2-ol] and Zami 1327 [1-(6-nitro-3-methyl-phenoxy)-3-tert-butylaminopropan-2-ol], were found to be contaminated by expoxides which are direct acting mutagens on TA 100 and TA 1535 in the Salmonella/microsome mutagenicity test. Because of the suggested correlation between mutagenicity and carcinogenicity of a chemical [10,11], beta-adrenergic blocking agents contaminated by mutagenic expoxide impurities may be a health hazard.
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D004340:Drug Contamination; D004852:Epoxy Compounds / Q000032:analysis / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D009152:Mutagenicity Tests; D011412:Propanolamines / Q000032:analysis*; D012486:Salmonella typhimurium / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D011412:Propanolamines; C028476:Zami 1327; C028475:ZAMI 1305