Comparative in vitro investigations on the dialysability of hypnotic and psychotropic drugs by hemodialysis and controlled sequential ultradiffusion.
The efficiency of hemodialysis and controlled sequential ultradiffusion (CSU) for the elimination of toxic drug concentrations was tested by in vitro-investigations. In the 6 benzodiazepin derivatives tested, the clearance is markedly higher at a blood flow of 200 ml/min than at 100 ml/min. Pyrithyldione, glutethimide and phenobarbital are better dialysed than the benzodiazepines with exception of chlordiazepoxide. In comparison with hemodialysis, hemofiltration by means of CSU was less effective because of the small amount of ultrafiltrate obtained.
D014151:Anti-Anxiety Agents / Q000097:blood; D001569:Benzodiazepines; D004058:Diffusion; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood*; D010634:Phenobarbital / Q000097:blood; D010880:Piperidines / Q000097:blood; D011619:Psychotropic Drugs / Q000097:blood*; D006435:Renal Dialysis; D014462:Ultrafiltration
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D010880:Piperidines; D011619:Psychotropic Drugs; D001569:Benzodiazepines; D010634:Phenobarbital