The Ca2+/C1- dependent L-[3H]glutamate binding: a new receptor or a particular transport process?
Ca2+/C1- increases the L-[3H]glutamate binding to rat brain synaptic membranes. It was suggested that Ca2+/C1- expresses a new class of glutamate receptors. We report several lines of evidence suggesting that Ca2+/C1- in fact favours a glutamate transport into membrane vesicles. This finding may serve to reconcile most of the discrepancies found in the literature on the glutamate binding and its pharmacology.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology*; D002712:Chlorides / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism*
D002712:Chlorides; D005971:Glutamates; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D002118:Calcium