Electrostatic components of drug-receptor recognition. II. The DNA-binding antibiotic actinomycin.
The semiempirical molecular orbital method PCILO has been used to study the electronic charge distribution and conformation of the antibiotic actinomycin. Molecular electrostatic potential fields have been constructed in three-dimensional space round the molecule and displayed stereoscopically together with contour maps in the orthogonal planes relative to that of the chromophore. It was found that the drug has a considerable dipole moment and that the electrostatic fields can be separated into two large regions; an area of positive potential surrounds the chromophore and one of negative potential is directed away from the peptide rings. In this and the preceding paper these observations are discussed with respect to drug-receptor recognition phenomena. Pattern-matching of complementary electrostatic fields between the drug and polynucleotide receptor can be discerned.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA; D003609:Dactinomycin; D004560:Electricity; D009690:Nucleic Acid Conformation; D013816:Thermodynamics
D003609:Dactinomycin; D004247:DNA