[Structuro-metabolic integration of gastric endocrine cells in the presence of a disruption in hormone balance].
In experimentally hyperthyroid rats an increased amount of gastrin-producing (G) and histamine-producing (ECl) cells was noted by means of immunofluorescent biochemical methods and electron microscopically. Increased amount of the ECl cells was combined with a rise in histamine contents in the gastric mucosa. Hydrocortisone injections resulted in degranulation of the G- and ECl-cells. After hydrocortisone injection, the amount of histamine decreased more than two-fold. It was demonstrated that not only parietal glandulocytes, but also the gastric endocrine cells participated in disorders of a complex acid-producing mechanism.
D000818:Animals; D005753:Gastric Mucosa / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D005755:Gastrins / Q000378:metabolism; D006636:Histamine Release; D006651:Histocytochemistry; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors
D005755:Gastrins; D012701:Serotonin; D013004:Somatostatin; D013974:Thyroxine; D006854:Hydrocortisone
Strukturno-metabolicheskie integratsii éndokrinnykh kletok zheludka v usloviiakh narushennogo gormonal'nogo balansa.