LH-RH therapy in functional amenorrhea based on clinical subclassification.
The diagnostic approach to functional amenorrhea comprising a gestagen test, an LH-RH test, and the response to clomiphene as well as the recording of endogenous LH episodes allows a subclassification of the patients with regard to different therapeutic approaches. According to the degree of endogenous LH-RH deficiency, which is reflected by this diagnostic workup, a therapy with clomiphene alone, LH-RH combined with clomiphene, or LH-RH alone is effective. To avoid paradoxical effects any LH-RH substitution has to meet physiological conditions. Thus pulsatile and low-dose LH-RH administration of varied duration proved able to prime the hypothalamo-pituitary unit for either clomiphene or gonadal feedback signals resulting in ovulation and corpus luteum formation.
D000568:Amenorrhea / Q000145:classification / Q000188:drug therapy*; D002996:Clomiphene / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D011374:Progesterone / Q000097:blood; D011372:Progestins; D013997:Time Factors
D011372:Progestins; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D007986:Luteinizing Hormone