[New developments concerning the neuron cell membrane: advances in the structural analysis of transmembrane ion channels].
Information processing in the brain requires the activation of electrically and chemically gated ion channels in the neuronal plasma membrane. Recently, the function and the molecular composition of some of these membrane proteins have become the subject of extensive biochemical and biophysical analysis. From the currently available data, it is proposed that the architecture of different neuronal ion channels obeys common structural principles which may have resulted from a divergent evolution of a limited number of ancestor transmembrane polypeptides.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D005998:Glycine / Q000502:physiology; D007473:Ion Channels / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D011963:Receptors, GABA-A / Q000502:physiology; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter / Q000502:physiology; D011978:Receptors, Nicotinic / Q000502:physiology; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D011963:Receptors, GABA-A; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter; D011978:Receptors, Nicotinic; D012964:Sodium; D005998:Glycine
Neues von der Nervenzellmembran. Fortschritte bei der Strukturanalyse transmembranärer Ionenkanäle.