[Effects of systemic administration of kainic acid on GABAergic and glutaminergic transmission in various areas of the brain].
In the present study that Authors have investigated the effects of systemic injection of kainic acid on aminoacidergic transmission of different rat brain regions. Kainic acid has been used to produce an experimental model of limbic epilepsy characterized by two different phases (KA1 and KA2). Results obtained show a significant decrease of glutamic and aspartic acids (excitatory aminoacids) and glicine and taurine (inhibitory aminoacids) in both phases at hippocampal level. On the contrary GABA concentration seems to be increased.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D005973:Glutamine / Q000502:physiology*; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011759:Pyrrolidines; D005973:Glutamine; D005680:gamma-Aminobutyric Acid; D007608:Kainic Acid
Effetti della somministrazione sistemica di acido kainico sulla transmissione GABAergica e glutamatergica in diverse aree cerebrali.