title: Anticonvulsive properties of 5-allyl-(beta-hydroxy)propyl-N-phenylbarbituric acid and the corresponding lactone.
abstract: The anticonvulsive effects of 5-allyl-(beta-hydroxy)propyl-N-phenylbarbituric acid (AP) and the product of its tissue and extraneous metabolism, alpha-allyl-alpha-allophanyl-gamma-butyrolactone (T1), were compared with the effect of phenobarbital. The anticonvulsive action of the substituted butyrolactone was more potent but shorter than that of AP, and the drug showed no hypnotic or general anesthetic action. The effect of AP was similar but much more prolonged.
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants; D001463:Barbiturates / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D003292:Convulsants; D004597:Electroshock; D005663:Furans / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology; D012640:Seizures / Q000503:physiopathology
chemical_list: D000927:Anticonvulsants; D001463:Barbiturates; D003292:Convulsants; D005663:Furans; C006468:5-allyl-5-(beta-hydroxypropyl)-N-phenylbarbituric acid; C006464:alpha-allyl-alpha-allophanyl-gamma-butyrolactone; D015107:4-Butyrolactone; D010634:Phenobarbital