A study of the mechanism of cerebral hyperexcitability after irradiation.
Whole-body irradiation at a lethal dose induced an early and transient perturbation of 3H-Muscimol specific binding in the mouse cerebellum. The density of high affinity binding sites was decreased and was associated with an increased affinity. This effect can explain early radio-induced cerebral hyperexcitability. Previous injection of cysteamine, which protects against cerebral hyperexcitability, also offers a good protection against this effect.
D000818:Animals; D002531:Cerebellum / Q000378:metabolism / Q000528:radiation effects*; D003543:Cysteamine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051379:Mice; D009118:Muscimol; D011837:Radiation-Protective Agents; D011963:Receptors, GABA-A / Q000378:metabolism; D014916:Whole-Body Irradiation / Q000009:adverse effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D011837:Radiation-Protective Agents; D011963:Receptors, GABA-A; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003543:Cysteamine