Improvement of shuttle-box avoidance by combinations of orotic acid and central stimulants.
The effect of orotic acid and central stimulants on retention of shuttle-box avoidance was investigated in rats. Orotic acid (100 mg/kg) was injected 30 min before training; caffeine (20mg/kg), strychnine (1 mg/kg), or methylphenidate (10 mg/kg) were injected immediately after training. When given alone, these drugs improved avoidance retention when tested 24 h after training. However, improvement of retention was much more evident when orotic acid was given in combination with a stimulant. The data are discussed in relation to the role of macromolecule synthesis and arousal in memory formation.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D008568:Memory / Q000187:drug effects*; D008774:Methylphenidate / Q000494:pharmacology; D009963:Orotic Acid / Q000494:pharmacology*; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects*; D013331:Strychnine / Q000494:pharmacology
D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D002110:Caffeine; D009963:Orotic Acid; D013331:Strychnine