[Gas chromatographic method for the quantitative determination of ftoratsizin and its N-dealkylated metabolites in animal and human biological material].
Conditions have been selected, providing the most complete transformation of ftoracizin 10-(beta-diethylaminopropionyl)-2-trifluoromethylphenothiazine and its two dealkylated metabolites--deethylftoracizin 10-(beta-ethylaminopropionyl)-2-trifluoromethylphenothiazine and dediethylftoracizin 10-(beta-aminoprpiony 17-2-trifluoromethylphenothiazine to 10-akryloyl-2-trifluoromethylphenothiazine in the injector of a chromatograph. The detector for electrons 63Ni uptake was extremely sensitive to the above substance. A method has been developed for quantitative determination of ftoracizin, diethylftoracizin and dediethylftoracizin in animal and human bioloigcal material.
D000818:Animals; D014150:Antipsychotic Agents / Q000032:analysis* / Q000378:metabolism; D002415:Cats; D002849:Chromatography, Gas / Q000379:methods*; D002855:Chromatography, Thin Layer; D003640:Dealkylation; D004285:Dogs; D006801:Humans; D008099:Liver / Q000032:analysis; D010640:Phenothiazines / Q000032:analysis*; D051381:Rats
D014150:Antipsychotic Agents; D010640:Phenothiazines; C001228:fluoracizine
Gazokhromatograficheskiĭ metod kolichestvennogo opredeleniia ftoratsizina i ego N-dezalkilirovannykh metabolitov v biologicheskom materiale zhivotnykh i cheloveka.