title: Tetanic stimulation affects the metabolism of phosphoinositides in hippocampal slices.
abstract: Tetanic but not low frequency stimulation of the perforant path in rat hippocampal slices results in changes in the metabolism of phosphoinositides and phosphatidic acid. The phosphorylation of other, non-inositol lipids was not affected by the high frequency stimulation. The observed changes in phosphoinositide metabolism are complex and biphasic, lasting at least 4 h after the termination of the tetanus. The present data support the notion that membrane phosphoinositides play a role in synaptic function.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000378:metabolism*; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008563:Membrane Lipids / Q000502:physiology; D010712:Phosphatidic Acids / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D009435:Synaptic Transmission
chemical_list: D008563:Membrane Lipids; D010712:Phosphatidic Acids; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols