[Clinical studies on cefmenoxine concentration in prostatic tissue and bladder wall].
Clinical studies on cefmenoxime (CMX) concentration in prostatic tissue and bladder wall were made and the following results were obtained. In 40 patients undergoing operation, 1 g of CMX was administered intravenously by bolus technique and CMX levels in peripheral blood, prostatic tissue and bladder wall were examined. The maximum level of prostatic tissue was 35 micrograms/g after 0.41 hour and bladder wall was 62 micrograms/g after 0.37 hour, and T1/2 was 1.41 hours both. CMX, a new broad spectrum cephalosporin, can be considered as one of the highly useful antibiotics for the treatment of postoperative infection.
D015281:Cefmenoxime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D011467:Prostate / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism*
D015281:Cefmenoxime; D002439:Cefotaxime