title: Breakdown of P.G.E. 1 synthesis is responsible for the acquired immunodeficiency syndrome.
abstract: This hypothesis suggests that repeated viral infections disrupt the biosynthesis of P.G.E. 1 and nullify a major system by which t lymphocytes are regulated. It is hypothesized that a breakdown of P.G.E. 1 synthesis is responsible for the acquired immunodeficiency syndrome and the frequently associated Kaposi's sarcoma. A means of restoring P.G.E. 1 synthesis and reversing the immunodeficiency is proposed.
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000517:prevention & control; D000262:Adenylyl Cyclases / Q000378:metabolism; D000527:Alprostadil; D000242:Cyclic AMP / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011458:Prostaglandins E / Q000096:biosynthesis*; D012514:Sarcoma, Kaposi / Q000517:prevention & control; D013601:T-Lymphocytes / Q000276:immunology; D014777:Virus Diseases / Q000150:complications / Q000276:immunology / Q000378:metabolism
chemical_list: D011458:Prostaglandins E; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000527:Alprostadil