Is cutaneous flushing prostaglandin mediated?
Intravenous administration of nicotinic acid (25 mg), resulted in a readily reproducible facial flush. The development of this flush was inhibited by two prostaglandin synthetase inhibitors, indomethacin and benorylate, but was not affected by the administration of the opiate receptor antagonist naloxone. Indomethacin, the agent with the greater anti-prostaglandin activity, was markedly more effective than benorylate in inhibiting the nicotinic-acid-induced rise in facial temperature. These findings will be useful in the in vivo assessment of the activity of prostaglandin inhibitors.
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004890:Erythema / Q000209:etiology*; D005145:Face / Q000098:blood supply*; D006801:Humans; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D011897:Random Allocation; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature
D009539:Nicotinic Acids; D011448:Prostaglandin Antagonists; D011453:Prostaglandins