Radiation-induced crosslinking of cytosine.
Formation of dimers upon gamma irradiation of cytosine, 2'-deoxycytidine, and 2'-deoxycytidine-5'-monophosphate in N2O-saturated aqueous solutions was found to be a major process. Quantitative measurements revealed that more than 50% of OH adduct radicals of cytosine undergo dimerization. Derivatized dimers and monomeric products were separated and tentatively identified by combined capillary gas chromatography-mass spectrometry.
D003037:Cobalt Radioisotopes; D003596:Cytosine / Q000528:radiation effects*; D003841:Deoxycytidine / Q000528:radiation effects; D003843:Deoxycytidine Monophosphate / Q000528:radiation effects; D005720:Gamma Rays; D008401:Gas Chromatography-Mass Spectrometry; D006878:Hydroxides; D017665:Hydroxyl Radical
D003037:Cobalt Radioisotopes; D006878:Hydroxides; D003841:Deoxycytidine; D003843:Deoxycytidine Monophosphate; D017665:Hydroxyl Radical; D003596:Cytosine