title: Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein.
abstract: Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D015232:Dinoprostone; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007375:Interleukin-1 / Q000494:pharmacology*; D053583:Interleukin-1beta; D051379:Mice; D003012:Microbial Collagenase / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D013552:Swine; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D053583:Interleukin-1beta; D011458:Prostaglandins E; D003012:Microbial Collagenase; D015232:Dinoprostone; D013936:Thymidine