Synthesis and anxiolytic activity of a series of pyrazino[1,2-a][1,4]benzodiazepine derivatives.
The synthesis and biological evaluation of some derivatives of pyrazino[1,2-a][1,4]benzodiazepines for anxiolytic and antidepressant activity are presented. Significant levels of anxiolytic activity were noted for 7-(o-chlorophenyl)-9-chloro-1,2,3,4,4a,5-hexahydro-3-methylpyrazino[1,2-a];E11,4]benzodiazepine (4b).
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis; D000927:Anticonvulsants / Q000138:chemical synthesis; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D003975:Diazepam / Q000378:metabolism; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000138:chemical synthesis; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011719:Pyrazines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D006633:Histamine Antagonists; D011719:Pyrazines; D011955:Receptors, Drug; D001569:Benzodiazepines; D012701:Serotonin; D001058:Apomorphine; D003975:Diazepam; D009638:Norepinephrine