title: Kidney function in patients with affective disorders with and without lithium therapy.
abstract: The ability to concentrate the urine was estimated in healthy volunteers, patients with affective disorders who had never received lithium and lithium-treated patients. Patients with affective disorders who had never received lithium were found to have significantly lower concentrating capacity than healthy volunteers. However, lithium-treated patients had still lower concentrating capacity and differed significantly both from healthy volunteers and from patients who had never received lithium. Furthermore, in a subgroup of lithium-treated patients investigated twice with an interval of 6 months, a progressive decrease in concentrating capacity was found, indicating the importance of lithium therapy.
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000188:drug therapy* / Q000503:physiopathology; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000009:adverse effects; D001714:Bipolar Disorder / Q000188:drug therapy; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007671:Kidney Concentrating Ability / Q000187:drug effects; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D008094:Lithium