Multiple sites of action for anxiogenic drugs: behavioural, electrophysiological and biochemical correlations.
This review describes animal models of anxiety that are able to identify an anxiogenic drug effect. Evidence is reviewed for the anxiogenic action of several drugs that act at the GABA-benzodiazepine-chloride ionophore complex in the brain. The effects of their combinations with various other drugs thought to act at the same sites are discussed. The classification of these drugs on the basis of their behavioural profiles is compared with their classification based on biochemical and electrophysiological studies.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000494:pharmacology; D001665:Binding Sites / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology; D002415:Cats; D005442:Flumazenil; D006801:Humans; D051379:Mice; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism
D001570:Benzodiazepinones; D002243:Carbolines; D011963:Receptors, GABA-A; C037480:picrotoxinin receptor; C028513:4'-chlorodiazepam; D005442:Flumazenil; C024915:beta-carboline-3-carboxylic acid ethyl ester