title: Plasmid-borne streptothricin resistance in gram-negative bacteria.
abstract: Plasmids, which code for a new type of drug resistance due to the acetylation of streptothricin and belonging to various incompatibility groups (I1, I2, W3, FII, S, X, and N) were identified in gram-negative bacteria. The gene for the acetyltransferase is closely linked to a gene for the streptomycin/spectinomycin adenylyltransferase AAD-3" on a novel type of a transposon, designated Tn1825. This is related to Tn7.
mesh_terms: D000123:Acetyltransferases / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004251:DNA Transposable Elements; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D005798:Genes, Bacterial; D009713:Nucleotidyltransferases / Q000235:genetics; D011815:R Factors; D013309:Streptothricins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D013309:Streptothricins; D000123:Acetyltransferases; C044496:streptothricin acetyltransferase; D009713:Nucleotidyltransferases; C022682:streptomycin-spectinomycin adenylyltransferase