The development of rat brain bombesin-like peptides and their receptors.
The development of bombesin-like peptides and their receptors was determined in 9 different rat brain regions. The concentration of immunoreactive bombesin increased dramatically in all brain regions examined during the third week after birth. In contrast, the density of [125I-Tyr4]bombesin binding sites was near maximal in all brain regions examined by the second postnatal week. These data indicate that the development of receptors precede bombesin-like peptide production.
D000367:Age Factors; D000818:Animals; D001839:Bombesin / Q000032:analysis*; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry; D002531:Cerebellum / Q000032:analysis; D006624:Hippocampus / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis; D008636:Mesencephalon / Q000032:analysis; D009830:Olfactory Bulb / Q000032:analysis; D010455:Peptides / Q000032:analysis*; D051381:Rats; D018004:Receptors, Bombesin; D011956:Receptors, Cell Surface / Q000032:analysis*
D010455:Peptides; D018004:Receptors, Bombesin; D011956:Receptors, Cell Surface; D001839:Bombesin