TRH-induced hyperprolactinemia and pituitary-ovarian function.
To elucidate the role of prolactin in the control of pituitary-ovarian function, eight healthy women were given 80 mg of synthetic thyrotropin-releasing hormone (TRH) orally on two consecutive days during the luteal phase of their menstrual cycle. TRH elevated serum prolactin to a mean concentration of 43.8 ng/ml on the first day and to 15.5 ng/ml on the second day. The reduced response to the second TRH dose was statistically significant (p < 0.05). Accompanying changes in concentrations of gonadotropins or ovarian steroids were not consistent. Short-term oral administration of TRH and/or the temporary hyperprolactinemia induced by its use do not modify the pituitary-ovarian function during the luteal phase of the menstrual cycle.
D000328:Adult; D001774:Blood Chemical Analysis; D005260:Female; D006801:Humans; D010053:Ovary / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology*; D011388:Prolactin / Q000502:physiology*; D013973:Thyrotropin-Releasing Hormone / Q000502:physiology*
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin