Futile xylitol cycle in Lactobacillus casei.
A futile xylitol cycle appears to be responsible for xylitol-mediated inhibition of growth of Lactobacillus casei Cl-16 at the expense of ribitol. The gratuitously induced xylitol-specific phosphoenolpyruvate-dependent phosphotransferase accumulates the pentitol as xylitol-5-phosphate, a phosphatase cleaves the latter, and an export system expels the xylitol. Operation of the cycle rapidly dissipates the ribitol-5-phosphate pool (and ultimately the energy supply of the cell), thereby producing bacteriostasis.
D002250:Carbon Radioisotopes; D007700:Kinetics; D007780:Lacticaseibacillus casei / Q000254:growth & development / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D012255:Ribitol / Q000378:metabolism; D014993:Xylitol / Q000378:metabolism*
D002250:Carbon Radioisotopes; D012255:Ribitol; D010744:Phosphoric Monoester Hydrolases; D014993:Xylitol