Reduction of amygdaloid kindled seizures by an analog of ACTH/MSH.
A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy--the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000679:Amygdala / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants; D001812:Blood-Brain Barrier; D004195:Disease Models, Animal; D004827:Epilepsy / Q000188:drug therapy; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000517:prevention & control*
D000927:Anticonvulsants; D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone