[Analysis and criticism of hemodynamic investigations during respiratory analeptic dispensing (author's transl)].
Almitrine is a respiratory analeptic acting on peripherical chemoreceptors. The hemodynamic effects have been studied with chronic respiratory diseases. The works have shown that almitrine produces an increase of pulmonary arterial pressure due to the raising of pulmonary vascular resistances by stimulation of peripherical chemoreceptors. Studying again the hemodynamic investigations with chronical respiratory failure it has been interesting to consider the effects of the produce with patients whose gazometric parameters have been normalized by artificial ventilation at FiO2 = 1, so as to produce a saturation of peripherical chemoreceptors. The results show that infused almitrine keeps hypertensive properties on pulmonary arterial with raising of pulmonary arterial resistances; the pulmonary vasoconstrictor effect is kept in spite of a normalization of blood gases. So it is necessary to look after pulmonary arterial pressure of patients receiving almitrine, that whatever the pre-existing pulmonary arterial pressure may be.
D000368:Aged; D015765:Almitrine; D001794:Blood Pressure / Q000187:drug effects; D001982:Bronchial Diseases / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002908:Chronic Disease; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008171:Lung Diseases / Q000503:physiopathology; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D014227:Triazines / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D010879:Piperazines; D014227:Triazines; D015765:Almitrine
L'administration f'un analeptique respiratoire. Analyse et critiques des explorations hémodynamiques.