[Action of the alkyl derivatives of amphotericin B on the conductivity of bilayer lipid membranes].
Amphotericin B alkyl derivatives increased conductivity of bilayer membranes by formation of channels in them. The properties of such channels were studied. A new method for determination of the polyene antibiotic toxicity is described. The method is based on measurement of the constant of the relaxation time on the antibiotic removal from the membrane solution. It was shown that the amphotericin B alkyl derivatives had very low toxicity for the mammalian cells and were highly toxic for the fungal cells. These antibiotics may be used as new effective antifungal compounds.
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects; D008051:Lipid Bilayers / Q000494:pharmacology*; D008563:Membrane Lipids / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D012995:Solubility; D013329:Structure-Activity Relationship; D013997:Time Factors
D007473:Ion Channels; D008051:Lipid Bilayers; D008563:Membrane Lipids; D000666:Amphotericin B
Deĭstvie alkil'nykh proizvodnykh amfoteritsina B na provodimost' bisloĭnykh lipidnykh membran.