Failure of somatostatin to inhibit epinephrine (adrenaline)-stimulated hepatic glucose output in vitro.
Somatostatin has no effect on epinephrine (adrenaline)-stimulated hepatic glucose output in the isolated perfused rat liver, which suggests that the peptide does not inhibit the phosphorylase enzyme system.
D000818:Animals; D004837:Epinephrine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005947:Glucose / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin; D005947:Glucose; D004837:Epinephrine