Antiarrhythmic effects of four different beta-adrenergic blockers in the mouse chloroform arrhythmia model.
The antiarrhythmic activity of four different beta-adrenergic blockers was assessed in the mouse chloroform arrhythmia model. ED50 values and 95% confidence intervals established by i.p. administration of drug were: propranolol (22.8, 10.9--67.0 mg/kg), sotalol (38.0, 15.9--58.5 mg/kg) and practolol (167, 111--235 mg/kg). Butoxamine provided some protection against the arrhythmia within a narrow dose range (53 to 79 mg/kg).
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002725:Chloroform; D008297:Male; D051379:Mice
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D002725:Chloroform