Regulation of nitrogen metabolism in glutamine auxotrophs of Klebsiella pneumoniae.
We examined the regulation of nitrogen metabolism in four classes (glnA, glnB, glnF, and glnG) of Gln- auxotrophs of Klebsiella pneumoniae. These studies indicate that glutamine synthetase does not directly mediate the physiological response to NH4+ in this organism. We present evidence suggesting that the effect of NH4+ on the expression of genes involved in nitrogen metabolism involves the products of the glnF and glnG genes.
D002874:Chromosome Mapping; D005796:Genes; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009584:Nitrogen / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013489:Suppression, Genetic
D000644:Quaternary Ammonium Compounds; D005974:Glutamate-Ammonia Ligase; D009584:Nitrogen