Diffusion of ceftriaxone into the cerebrospinal fluid of adults.
Fourteen adults, three recovering from bacterial meningitis, were given a single 2 g dose of ceftriaxone or three 2 g doses at 12-hourly intervals. The mean per cent penetration of drug into cerebrospinal fluid (CSF) across uninflamed meninges was 1.5%. These levels, although low, are bactericidal in vitro against most pathogens causing meningitis.
D000328:Adult; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D002443:Ceftriaxone; D004058:Diffusion; D006801:Humans; D008581:Meningitis / Q000188:drug therapy
D002443:Ceftriaxone; D002439:Cefotaxime