Reliable routine method for determination of perazine in serum by thin-layer chromatography with an internal standard.
The use of a high-performance thin-layer chromatography linear chamber and of thioridazine as internal standard increases the performance of thin-layer chromatography (TLC) with direct densitometric scanning, and allows the rapid determination of serum levels of the neuroleptic drug perazine under usual therapeutic conditions. TLC is superior to gas-liquid chromatography in so far as the main metabolite desmethylperazine can be easily separated and detected by the same procedure.
D014150:Antipsychotic Agents / Q000097:blood*; D002855:Chromatography, Thin Layer / Q000379:methods*; D006801:Humans; D010464:Perazine / Q000008:administration & dosage / Q000097:blood*; D010640:Phenothiazines / Q000097:blood
D014150:Antipsychotic Agents; D010640:Phenothiazines; C017636:10-piperazinylpropylphenothiazine; D010464:Perazine