Somatically recorded Ca-currents in guinea-pig hippocampal and olfactory cortex neurones are resistant to adenosine action.
Inward membrane currents were recorded in tetrodotoxin-treated neurones of hippocampus and olfactory cortex in vitro after impalement with CsCl-containing microelectrodes to suppress potassium conductances. They were blocked by the Ca2+ -channel blocker Cd2+ but were unaffected by adenosine alone (up to 1 mM), adenosine (20 microM) in the presence of the uptake blocker dipyridamole (1 microM) or the stable analogue cyclohexyladenosine (100 microM). This ineffectiveness of adenosine on Ca-currents was in contrast to its known potent suppression of synaptic transmission in these preparations, and its inhibition of Ca-dependent action potentials.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008032:Limbic System / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D009833:Olfactory Pathways / Q000187:drug effects
D007473:Ion Channels; D000241:Adenosine; D002118:Calcium