Blockade of chlorpropamide-alcohol flushing by indomethacin suggests an association between prostaglandins and diabetic vascular complications.
Chlorpropamide/alcohol flushing (CPAF), found in many patients with non-insulin-dependent diabetes (NIDD), can be blocked by indomethacin in most patients who are free of vascular complications but not in those with such complications. Since indomethacin is a prostaglandin inhibitor this finding suggests that prostaglandins may be involved in the aetiology of vascular diseases in NIDD. All 6 pairs of identical twins with CPAF, of whom 2 pairs were disocrdant for diabetes, were concordant for indomethacin blocking, which suggests that the block has a genetic basis. The difference in the response of CPAF to indomethacin in diabetic patients with and without vascular complications is probably the first indication of a metabolic difference between these two types of patient.
D001808:Blood Vessels / Q000187:drug effects*; D002747:Chlorpropamide / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000209:etiology*; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005145:Face / Q000098:blood supply*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008875:Middle Aged; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology*; D012881:Skin Temperature / Q000187:drug effects; D014427:Twins
D011453:Prostaglandins; D000431:Ethanol; D002747:Chlorpropamide; D007213:Indomethacin