Electrophysiological characteristics of tobanum, a new beta receptor blocking agent.
The electrophysiological properties of Tobanum (a new beta receptor blocking drug) were studied in 14 patients by the aid of His electrography and programmable electrical stimulation of the heart. On the effect of Tobanum (0,9 mg by slow i.v. injection), three characteristic changes could be detected: 1. The impulse conduction in AV node slowed down markedly. 2. The heart frequency decreased. 3. The effective refractory period of the atrium significantly increased. Tobanum seems to be a very effective antiarrhythmic drug for the treatment of supraventricular tachycardias.
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000889:Anti-Arrhythmia Agents; D002648:Child; D002675:Child, Preschool; D004594:Electrophysiology; D005260:Female; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D012032:Refractory Period, Electrophysiological / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D011412:Propanolamines; D011433:Propranolol; C025725:tobanum