[Effect of anti-hypertensive treatment on plasma lipids and lipoproteins (author's transl)].
The authors attempted to evaluate through a literature review, lipid and lipoprotein changes induced by anti-hypertensive drugs (especially diuretics and beta-blockers). Generally, these drugs induce a modification of the lipid and lipoprotein profile towards profile atherogenicity by a moderate increase in total cholesterol, a marked increase in triglycerides and very-low-density lipoprotein triglycerides, and a decrease in high-density lipoprotein cholesterol. In theory, these changes could decrease or cancel the reduction in cardio-vascular risk obtained through the antihypertensive treatment but current data do not allow to confirm or disprove this hypothesis. However, it is certain that adherence to a suitable life-style and good dietary habits tend to reduce the associated risk factors and compensates, at least in part, for the effects of hypotensive drugs on the lipids and lipoproteins.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004232:Diuretics / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D004232:Diuretics; D008055:Lipids; D008074:Lipoproteins
Effets des traitements hypotenseurs sur les lipides et lipoprotéines plasmatiques.