Platelet aggregates in peripheral and coronary-sinus blood in patients with spontaneous coronary-artery spasm.
Five out of twenty patients with vasotonic angina had frequent spontaneous attacks with dramatic ST-segment alterations. These attacks were consistently associated with an increase in platelet aggregates in coronary-sinus blood but not arterial blood. This increase in platelet aggregates during coronary-artery spasm suggests a potential causal role for the platelet in this subset of patients with ischaemic heart-disease. However, the increase in platelet aggregates could be secondary to reduced coronary blood-flow.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D000788:Angina Pectoris, Variant / Q000097:blood* / Q000209:etiology; D002908:Chronic Disease; D003326:Coronary Circulation; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010974:Platelet Aggregation; D010979:Platelet Function Tests; D013035:Spasm / Q000150:complications; D009626:Terminology as Topic