Interference of Aslavital with the cytoenzymic changes induced by cold in the adrenal cortex of Wistar rats.
The repeated exposure to cold of 2-month- and 2-year-old rats resulted in an important depression of the activity of numerous enzymes in the adrenal cortex. The simultaneous treatment with Aslavital administered in successive doses prevented the decrease of the enzymic activity. It seems that Aslavital exerted a stimulating action on the biosynthesis processes of glucocorticoid hormones and subsequently induced the processes of acclimatization to cold in rats submitted to treatment.
D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000302:Adrenal Cortex / Q000187:drug effects / Q000201:enzymology*; D000367:Age Factors; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D003080:Cold Temperature; D003576:Electron Transport Complex IV / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D011343:Procaine / Q000494:pharmacology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
C006642:aslavital; D011343:Procaine; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase