Induction in guinea-pigs of airway hyperreactivity and decreased lung beta-adrenoceptor number by 15-hydroperoxy-arachidonic acid.
Administration to guinea-pigs of 15-hydroperoxy-arachidonic acid (0.2 mg kg-1 i.p.) caused a 20% reduction of lung beta-adrenoceptor number. Furthermore, in vivo, a hyperreactivity of the airways to nebulized histamine was observed. In contrast, administration of 15-hydroxy-arachidonic acid (0.2 mg kg-1 i.p.) did not cause a significant change in either of these parameters.
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006893:Hydroxyeicosatetraenoic Acids / Q000494:pharmacology; D015289:Leukotrienes; D008054:Lipid Peroxides / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D015289:Leukotrienes; D008054:Lipid Peroxides; D011943:Receptors, Adrenergic, beta; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid; D006632:Histamine