Penetration of cefotaxime into heart valves, subcutaneous and muscle tissue of patients undergoing open-heart surgery.
Twenty-nine adult patients undergoing open-heart surgery were given 2 g cefotaxime as 5 min intravenous bolus injection preoperatively. Within 6 h cefotaxime serum concentrations declined from 81.0 to 6.3 mg/l. Subcutaneous tissue and muscle concentrations varied between 0.3 and 8.7 micrograms/g, heart valve concentrations varied between 2.2 and 13.0 micrograms/g. Cefotaxime concentrations in heart valves are high enough to inhibit most Gram-negative organisms causing postoperative wound infections and endocarditis.
D006348:Cardiac Surgical Procedures; D002439:Cefotaxime / Q000378:metabolism*; D005260:Female; D006351:Heart Valves / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011292:Premedication; D012867:Skin / Q000378:metabolism*
D002439:Cefotaxime