Brain gamma-glutamyltransferase levels in alcohol-fed rabbits.
Brain gamma-glutamyltransferase levels were determined in the cortex, cerebellum, medulla and mid-brain of 14 ethanol-fed and 10 control rabbits. In the ethanol-fed animals, brain gamma-glutamyltransferase activity was reduced. This reduction was more pronounced with 3 than with 6 months ethanol feeding, and significantly reduced gamma-glutamyltransferase activity was observed at each brain site when rabbits fed ethanol for 3 months were compared with non-ethanol-fed controls with similar calorie intake. Possible neuropharmacological implications are considered.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002531:Cerebellum / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D003342:Corpus Striatum / Q000201:enzymology; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008526:Medulla Oblongata / Q000201:enzymology; D011817:Rabbits; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D000431:Ethanol; D005723:gamma-Glutamyltransferase