Low incidence of chlorpropamide-alcohol flushing in diet-treated, non-insulin-dependent diabetes.
50 diet-treated, non-insulin-dependent diabetics were tested subjectively and objectively for chlorpropamide-alcohol flushing (CPAF) with a single challenge test. Of the 12 (24%) who reported a subjective flush, 9 (18%) also flushed when a placebo was given instead of chlorpropamide, so the true incidence of chlorpropamide-alcohol flushing was 4% (1 patient was not retested with placebo). In a control group of 21 non-diabetics, 2 showed the specific CPAF phenomenon. Temperature measurement did not improve discrimination, but it did show a faster rise in facial temperature in CPAF-positive subjects than in alcohol flushers. This study does not confirm previous higher estimates of the incidence of the CPAF phenomenon in non-insulin-dependent diabetes.
D000328:Adult; D000368:Aged; D002747:Chlorpropamide / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000178:diet therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D000431:Ethanol / Q000494:pharmacology*; D005145:Face / Q000098:blood supply*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D000431:Ethanol; D002747:Chlorpropamide