Lack of effect of the antihistamine drug clemastine on the potentiation of itch by prostaglandin E1.
The effect of clemastine fumarate, a histamine H1-antagonist, on the potentiation of itch by prostaglandin E1 (PGE1) was studied in normal humans. The antihistamine drug did not abolish the potentiation, which suggests that the effect of PGE1 on itch does not depend on the liberation of endogenous histamine.
D000328:Adult; D002974:Clemastine / Q000494:pharmacology*; D004357:Drug Synergism; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D011453:Prostaglandins / Q000502:physiology*; D011537:Pruritus / Q000503:physiopathology* / Q000517:prevention & control; D011759:Pyrrolidines / Q000494:pharmacology*; D012684:Sensory Thresholds / Q000187:drug effects
D006634:Histamine H1 Antagonists; D011453:Prostaglandins; D011759:Pyrrolidines; D002974:Clemastine