Maternal, fetal and aminiotic fluid ACTH, cortisol and prolactin in association with medical beta-adrenergic stimulation.
In view of observations indicating accelerated fetal pulmonary maturation after tocolytic therapy with beta-adrenergic agonists, this study was undertaken to determine whether the phenomenon is related to enhanced maternal or fetal ACTH, cortisol or prolactin secretion. The concentrations of ACTH, cortisol and prolactin in maternal venous blood, umbilical arterial and venous blood, and amniotic fluid were similar after short-term maternal intravenous infusion of isoxsuprine, fenoterol or isotonic saline, and they did not increase in the maternal venous blood during these treatments or during long-term treatment with intravenous ritodrine. These results suggest that the accelerated fetal pulmonary maturation induced by beta-adrenergic stimulation is not mediated by ACTH, cortisol or prolactin.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D000653:Amniotic Fluid / Q000032:analysis*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology; D005312:Fetal Blood / Q000032:analysis*; D005325:Fetal Organ Maturity / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D007556:Isoxsuprine / Q000494:pharmacology; D008168:Lung / Q000196:embryology; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011388:Prolactin / Q000032:analysis*; D012312:Ritodrine / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D005280:Fenoterol; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D012312:Ritodrine; D007556:Isoxsuprine; D006854:Hydrocortisone