Discordance between glucokinase activity and insulin and glucagon receptor changes occurring during liver regeneration in the rat.
During regeneration of rat livers following 70% hepatectomy, insulin binding sites on hepatocyte plasma membranes are increased after 24-48 hours, glucagon binding sites are reduced on days 2-8, and the resultant insulin/glucagon binding ratio is markedly increased. An apparent paradox was the finding of a depression of the activity of an insulin associated enzyme, glucokinase, at a time when the number of insulin binding sites was increased.
D000818:Animals; D004261:DNA Replication; D005934:Glucagon / Q000378:metabolism; D005941:Glucokinase / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018027:Receptors, Glucagon
D007328:Insulin; D011956:Receptors, Cell Surface; D018027:Receptors, Glucagon; D005934:Glucagon; D005941:Glucokinase; D011972:Receptor, Insulin