Antigen-induced arthritis: inflammation and antigen handling.
Data are summarized indicating that the degree and duration of antigen induced arthritis (AIA) influences handling of intra-articular (i.a.) antigen. Long term antigen retention was less in chronic as compared with transient joint inflammation, whereas i.a. antigen was cleared more rapidly from the joint in severe than in moderate AIA. In addition, the presence of ungoing AIA enhances initial elimination of i.a. injected antigen from the joint.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001168:Arthritis / Q000276:immunology*; D005620:Freund's Adjuvant / Q000008:administration & dosage*; D007249:Inflammation / Q000000981:diagnostic imaging / Q000276:immunology; D007270:Injections, Intra-Articular; D007457:Iodine Radioisotopes; D011817:Rabbits; D011877:Radionuclide Imaging; D012710:Serum Albumin, Bovine / Q000276:immunology; D013670:Sodium Pertechnetate Tc 99m
D000941:Antigens; D007457:Iodine Radioisotopes; D012710:Serum Albumin, Bovine; D005620:Freund's Adjuvant; D013670:Sodium Pertechnetate Tc 99m