title: [Clinical evaluation of sulbactam/cefoperazone for infections in the field of obstetrics and gynecology].
abstract: A daily dose of 2 or 4 grams of sulbactam/cefoperazone (SBT/CPZ) by drip infusion was given to 12 patients with gyneco-obstetrical infections and the results were following: The clinical effect was judged excellent in 2 cases, good in 9 cases and poor in 1 case, and the effective rate was 91.7%. Except for Streptococcus faecalis, the bacteriological effect was sufficient. A good effect was also seen in Pseudomonas cepacia resistant organism to other cephem antibiotics. Diarrhea was observed in 1 patient, and increases of GOT and GPT, possibly attributable to concomitantly used anticancer agent, were detected in another patient. In conclusion, SBT/CPZ with a 91.7% of efficacy rate, was useful in infections caused by beta-lactamase producing organisms and, thus, a useful agent for gyneco-obstetrical infections.
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D002438:Cefoperazone / Q000008:administration & dosage* / Q000009:adverse effects; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D008875:Middle Aged; D010397:Penicillanic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D011183:Postoperative Complications / Q000188:drug therapy; D011247:Pregnancy; D013407:Sulbactam; D065093:beta-Lactamase Inhibitors
chemical_list: D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; D002438:Cefoperazone; D010397:Penicillanic Acid; D013407:Sulbactam