Effect of desamino-cholecystokinin-octapeptide (CCK-7) on the intraluminal pressure and myoelectrical activity of the gall-bladder, stomach, and small intestine in conscious dogs.
Desamino-cholecystokinin-octapeptide (CCK-7) increased the gall-bladder pressure and decreased the gastric pressure following i.v. infusion in conscious dogs. In small intestine and Heidenhain pouch CCK-7 exerted an initial excitatory effect followed by an inhibitory effect on intraluminal pressure and peristalsis. In all organs the effect of CCK-7 on pressure was correlated with a change of spike discharge. CCK-7 is more potent on gastrointestinal motor activity than a Boots preparation of pancreozymin. The results suggest that CCK-7 at doses within the physiological range could be involved in the regulation of gastrointestinal motility.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D005704:Gallbladder / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D011312:Pressure; D012844:Sincalide / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects* / Q000294:innervation; D014628:Vagotomy
D010446:Peptide Fragments; C025997:cholecystokinin (27-33); D002766:Cholecystokinin; D012844:Sincalide