Studies on the mechanism of postetorphine catalepsy. Effects of clotiapine, haloperidol and rompun on postetorphine changes in concentrations of dopamine and noradrenaline in central nervous system of rats.
Changes in dopamine (DA) and noradrenaline (NA) concentrations in various central nervous system structures were compared in rats after administration of haloperidol, clotiapine and rompun with changes in these concentrations during etorphine-induced catalepsy. Besides that, these changes were compared with changes in DA and NA concentrations after etorphine administration during full action of haloperidol, clotiapine and rompun. Haloperidol, clotiapine and rompun prolonged the duration of etorphine-induced catalepsy in rats and modified significantly postetorphine changes in DA and NA concentrations in the investigated central nervous system structures. The action of haloperidol, clotiapine and rompun increasing the intensity of postetorphine catalepsy and the previously demonstrated anticataleptic and antietorphine action of agents stimulating the postsynaptic adrenergic structures in the central nervous system in rats may suggest that DA release from presynaptic structures is inhibited after etorphine.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002375:Catalepsy / Q000139:chemically induced / Q000378:metabolism*; D003987:Dibenzothiazepines / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004357:Drug Synergism; D005048:Etorphine / Q000009:adverse effects; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism*; D014991:Xylazine / Q000494:pharmacology
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D014991:Xylazine; D005048:Etorphine; D006220:Haloperidol; D004298:Dopamine; D009638:Norepinephrine