Hypothalamic alpha 2- and beta-adrenoceptor rhythms are correlated with circadian feeding: evidence from chronic methamphetamine treatment and withdrawal.
The circadian regulation of food intake in rats is correlated with a bimodal rhythm of beta-adrenoceptor binding in the lateral hypothalamus and a unimodal rhythm of alpha 2-adrenoceptor binding in the medial hypothalamus. Chronic methamphetamine treatment provides evidence for a functional correlation: beta-adrenoceptor binding in the lateral hypothalamus is reduced at dusk, together with reduction of food intake; alpha 2-adrenoceptor binding in the medial hypothalamus is increased at dawn, together with persistent food intake. Long-term changes in these two adrenergic systems are also correlated with homeostasis of food intake: 24-h mean beta-adrenoceptor binding is reduced and alpha 2-adrenoceptor binding is increased upon methamphetamine withdrawal, when rebound feeding occurs. Corticosterone, although normally coupled to adrenergic mechanisms that regulate feeding, is phase delayed after chronic methamphetamine treatment.
D000818:Animals; D001835:Body Weight; D002940:Circadian Rhythm; D003345:Corticosterone / Q000097:blood; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D008694:Methamphetamine; D003345:Corticosterone