Influence of the beta-blocking atenolol and other medications on visual reaction time.
Visual reaction time as a measure of vigilance and of the psychophysiological condition of subjects, was determined after combined physical and mental stress to examine the influence of beta blockade. Using the technique of electro-oculography, 40 subjects aged 25.7 +/- 6 years, with a mean blood pressure of 126/79 torr, were studied in a double-blind crossover design after application of placebo or 50 mg atenolol for 3 d. Visual reaction time was defined as the time between display of a peripheral light signal and the start of the eye movement that shifts the direction of gaze from the reference point to the stimulus. The results of the study show that, under these experimental conditions, there is a positive effect of beta blocker medication on vigilance. Findings of other authors are discussed. To prove the sensitivity of the test method in a preliminary study, the effects of the well-known drugs fenethylline-hydrochioride, diazepam, oxazepam, and alcohol on visual reaction time were investigated.
D000328:Adult; D000662:Amphetamines / Q000494:pharmacology; D001262:Atenolol / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008297:Male; D010076:Oxazepam / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects*; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors; D014785:Vision, Ocular / Q000187:drug effects*
D000662:Amphetamines; D000697:Central Nervous System Stimulants; D011412:Propanolamines; D000431:Ethanol; D001262:Atenolol; D010076:Oxazepam; D013806:Theophylline; D003975:Diazepam; C004518:fenethylline