title: Ergogenic aids.
abstract: The catabolism of bodily fuels provides the energy for muscular work. Work output can be limited by the size of fuel reserves, the rate of their catabolism, the build-up of by-products, or the neurologic activation of muscle. A substance that favorably affects a step that is normally limiting, and thus increases work output, can be considered an ergogenic aid. The maximal amount of muscular force generated during brief contractions can be acutely increased during hypnosis and with the ingestion of a placebo or psychomotor stimulant. This effect is most obvious in subjects under laboratory conditions and is less evident in athletes who are highly motivated prior to competition. Fatigue is associated with acidosis in the working musculature when attempts are made to maximize work output during a 4 to 15-minute period. Sodium bicarbonate ingestion may act to buffer the acid produced, provided that blood flow to the muscle is adequate. Prolonged intense exercise can be maintained for approximately two hours before carbohydrate stores become depleted. Carbohydrate feedings delay fatigue during prolonged exercise, especially in subjects who display a decline in blood glucose during exercise in the fasting state. Caffeine ingestion prior to an endurance bout has been reported to allow an individual to exercise somewhat more intensely than he or she would otherwise. Its effect may be mediated by augmenting fat metabolism or by altering the perception of effort. Amphetamines may act in a similar manner. Water ingestion during prolonged exercise that results in dehydration and hyperthermia can offset fluid losses and allow an individual to better maintain work output while substantially reducing the risk of heat-related injuries.
mesh_terms: D000662:Amphetamines / Q000494:pharmacology; D001639:Bicarbonates / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D004040:Dietary Carbohydrates / Q000378:metabolism / Q000494:pharmacology; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology; D004326:Drinking; D006801:Humans; D006990:Hypnosis; D010807:Physical Endurance; D005082:Physical Exertion / Q000187:drug effects*; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate; D013177:Sports
chemical_list: D000662:Amphetamines; D001639:Bicarbonates; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D002110:Caffeine; D017693:Sodium Bicarbonate; D012964:Sodium