Glucagonoma syndrome: case report and literature review.
The glucagonoma syndrome is characterized by dermatitis, glucose intolerance, hypoaminoacidemia, and hyperglucagonemia secondary to an alpha-cell tumor of the pancreas. Other clinical features include anemia, glossitis, and weight loss. A 62-year-old woman with the syndrome sought medical attention for a chronic dermatitis. A skin biopsy was suggestive of necrolytic migratory erythema. A glucagonoma was surgically removed from the tail of the pancreas. Review of the literature indicates that 56 proven and 33 probable cases of glucagonoma syndrome have been reported.
D007516:Adenoma, Islet Cell / Q000473:pathology*; D000596:Amino Acids / Q000097:blood; D003872:Dermatitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D003920:Diabetes Mellitus / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D005935:Glucagonoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D010257:Paraneoplastic Syndromes; D012867:Skin / Q000473:pathology
D000596:Amino Acids