Effects of sulphasalazine on prostaglandin inactivation and synthesis in isolated lungs of guinea pig, rat and man.
Sulphasalazine 10(-4M) inhibited PGE2 inactivation in isolated perfused lungs from guinea pig, rat and man and, in guinea pig and rat lungs, inhibited 16,16-dimethyl PGE2 inactivation and accelerated efflux of radioactivity following injection of [14C]PGE2. In rat and human, but not in guinea-pig lung, sulphasalazine inhibited activation of exogenous arachidonate to PG-like substances. Thus sulphasalazine inhibited PG inactivation by inhibiting PG uptake; there was a marked species difference in its effects on arachidonate activation.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000378:metabolism*; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity; D012460:Sulfasalazine / Q000494:pharmacology*
D001095:Arachidonic Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D012460:Sulfasalazine; D007213:Indomethacin