The effect of antihypertensive therapy on abnormal leucocyte sodium transport in essential hypertension.
Sodium transport in leucocytes of essential hypertensives was studied in physiological media. Untreated hypertensives have depressed values for the total and ouabain-sensitive sodium efflux rate constant. Treatment with diuretics abolished this abnormality. These results are compatible with the presence of a circulating inhibitor of sodium transport in essential hypertension.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000584:Amiloride / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001581:Benzothiadiazines; D001794:Blood Pressure; D003971:Diastole; D004232:Diuretics; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000097:blood*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D010042:Ouabain; D000584:Amiloride; D012964:Sodium