Possible mechanisms implicated on the hypothermic effect induced by morphine in guinea-pig.
Morphine 50 mg/kg i.p. produced a hypothermic effect in unrestrained guinea-pigs and this effect was potentiated when animals were restrained. The morphine-induced hypothermia was antagonized by dexamethasone treatment (1 mg/kg 24 hr and 0.5 mg/kg i.p. 2 hr before morphine). Treatment with the inhibitor of peptide biosynthesis cycloheximide (10 mg/kg i.p. 24 and 2 hr before morphine) also inhibited the hypothermic effect of morphine. ACTH injected intracerebroventricular produced no changes in body temperature. These results are consistent with the hypothesis that anterior pituitary peptide beta-endorphin may play a role in the hypothermic effect produced by morphine in the guinea-pig.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007035:Hypothermia / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010908:Pituitary Hormones, Anterior / Q000502:physiology*; D012149:Restraint, Physical
D010908:Pituitary Hormones, Anterior; D009020:Morphine; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D003513:Cycloheximide