Acetylcholine receptor turnover in mice with passively transferred myasthenia gravis. I. Receptor degradation.
The in vivo degradation of endplate acetylcholine receptors was investigated in mice treated daily with IgG from 10 myasthenia gravis patients. Four preparations increased the rate of degradation. The number of endplate acetylcholine receptors after 7 days of IgG treatment was greater than that predicted on the basis of the increased degradation rate, suggesting a compensatory increase in receptor synthesis.
D000328:Adult; D000818:Animals; D000937:Antigen-Antibody Reactions; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000276:immunology* / Q000378:metabolism; D009469:Neuromuscular Junction / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*
D007074:Immunoglobulin G; D011950:Receptors, Cholinergic