Rhodopsin kinase activity in the mammalian pineal gland and other tissues.
Rhodopsin kinase, an enzyme involved in photochemical transduction in the retina, has been found in the mammalian pineal gland in amounts equal to those in the retina; other tissues had 7 percent of this amount, or less. This finding suggests that, in mammals, rhodopsin kinase functions in the pineal gland and other tissues to phosphorylate rhodopsin-like integral membrane receptors and is thereby involved in signal transduction.
D000818:Animals; D001921:Brain / Q000201:enzymology; D005136:Eye Proteins; D051606:G-Protein-Coupled Receptor Kinase 1; D008027:Light; D008168:Lung / Q000201:enzymology; D010766:Phosphorylation; D010870:Pineal Gland / Q000201:enzymology*; D010902:Pituitary Gland / Q000201:enzymology; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D012160:Retina / Q000201:enzymology; D014018:Tissue Distribution; D015032:Zinc / Q000494:pharmacology
D005136:Eye Proteins; D047428:Protein Kinase Inhibitors; D011943:Receptors, Adrenergic, beta; D011494:Protein Kinases; D051606:G-Protein-Coupled Receptor Kinase 1; C496765:Grk1 protein, rat; D015032:Zinc