Lack of effect of a purified diet on carbon tetrachloride or oxygen toxicity.
The study was designed to examine the effect of feeding a purified versus a cereal-based closed formula (control) diet on toxicity to carbon tetrachloride or oxygen. Twenty-eight-day-old male ICR mie were fed a purified or cereal-based closed formula diet for 14 or 84 days. After treatment with carbon tetrachloride or exposure to a 100% oxygen atmosphere, survival time and percentage survival were the same for mice fed either diet. In both dietary groups, carbon tetrachloride injection caused a similar decrease in hepatic nonprotein sulfhydryl compounds and glucose-6-phosphatase activity. It was concluded that, unlike previous findings with the herbicide paraquat, toxicity to carbon tetrachloride or oxygen is not increased by feeding a purified diet compared to a closed formula diet. The results provided further evidence to suggest that a free radical-lipid peroxidation process may not be the primary mechanism of the toxic effects of paraquat.
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D004032:Diet; D002523:Edible Grain; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010100:Oxygen / Q000633:toxicity*; D013438:Sulfhydryl Compounds / Q000378:metabolism
D013438:Sulfhydryl Compounds; D002251:Carbon Tetrachloride; D005952:Glucose-6-Phosphatase; D010100:Oxygen