Biochemical and histochemical estimations of liver gamma-glutamyltransferase activity in ethanol-fed rats.
Ethanol-fed rats showed significantly elevated plasma and liver gamma-glutamyltransferase activity, compared with rats fed carbohydrates isocalorically, or with untreated control animals. The activity of gamma-glutamyltransferase in liver was detected by means of both biochemical and histochemical methods. These data suggest that increased plasma gamma-glutamyltransferase activity commonly found in alcoholics can be related, at least in part, to a hepatic enhancement of the activity in the liver.
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D006651:Histocytochemistry; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism*
D000431:Ethanol; D005723:gamma-Glutamyltransferase