title: Axonal branching of ventral tegmental and raphe projections to the frontal cortex in the rat.
abstract: Axonal collateralization of neurons whose divergent branches innervate the medial prefrontal cortex (MFC) and the sulcal cortex was studied in the rat by using the retrograde double-labeling technique. Injections of bisbenzimide and propidium iodide into the MFC and sulcal cortex resulted in double-labeling of a small population of cells within the ventral tegmental area (VTA) and pars compacta of the substantia nigra (SNC). More extensive double-labeling was evident in the midbrain raphe nuclei. Collateralization++ therefore does not appear to be an important property of the dopamine innervation of the prefrontal cortex.
mesh_terms: D000818:Animals; D001369:Axons; D004298:Dopamine / Q000502:physiology; D005625:Frontal Lobe / Q000033:anatomy & histology*; D008032:Limbic System / Q000502:physiology; D008297:Male; D008636:Mesencephalon / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology; D011903:Raphe Nuclei / Q000033:anatomy & histology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission; D013681:Tegmentum Mesencephali / Q000033:anatomy & histology*
chemical_list: D004298:Dopamine