Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells.
It has been found that most immunoglobulin heavy(H)-chain gene diversity (D) segments carry their own 5' transcriptional promoter element. Transcription of rearrangements which use heavy-chain D and joining (J) segments in B-lymphoid cells ultimately leads to the production of a Dmu messenger RNA which contains the DJH segments linked to the mu heavy-chain constant region. If the D is joined to the JH segment in the appropriate translational reading frame, this Dmu mRNA is translated to yield a short Dmu protein with a variable DJH N-terminus.
D000011:Abelson murine leukemia virus / Q000235:genetics; D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D001483:Base Sequence; D001853:Bone Marrow / Q000276:immunology; D017252:CD3 Complex; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D005796:Genes; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D000954:Antigens, Surface; D017252:CD3 Complex; D007143:Immunoglobulin Heavy Chains; D007148:Immunoglobulin mu-Chains; D004262:DNA Restriction Enzymes