Benzodiazepines modify the agonist responses at a presynaptic GABA receptor.
The stimulus-induced release of [3H]glutamic acid from striatal tissue was actively modulated by a presynaptic GABA receptor. The agonist responses of this GABA receptor were modified stereoselectively by benzodiazepines at low concentrations. The results correlate well with effects seen in [3H]GABA binding experiments and as they demonstrate benzodiazepine-induced changes in GABA receptor properties in a tissue prism preparation, these results suggest that the mechanisms described for extensively disrupted preparations may also apply to whole tissue.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D004347:Drug Interactions; D005971:Glutamates / Q000378:metabolism; D066298:In Vitro Techniques; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011963:Receptors, GABA-A; D013237:Stereoisomerism
D014151:Anti-Anxiety Agents; D005971:Glutamates; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D011188:Potassium