[Peripheral mechanism of the phenomenon of fenibut habituation].
In spite of the appearance of the tolerance to phenibut in white rats at days 11-12 of its intraperitoneal administration (250 mg/kg), the drug injections (25 micrograms) into the lateral ventricles of the brain via permanent cannulas evoked, as before, a fall in the body temperature and synchronization of the electrocorticogram in rats. The tolerance to phenibut did not occur when the drug was injected daily (12 days) into the brain ventricles. A conclusion is made that the tolerance to phenibut has a peripheral character.
D000613:Aminobutyrates / Q000008:administration & dosage; D000818:Animals; D014151:Anti-Anxiety Agents; D001831:Body Temperature / Q000187:drug effects; D004361:Drug Tolerance; D004569:Electroencephalography; D006801:Humans; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D019966:Substance-Related Disorders / Q000209:etiology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000613:Aminobutyrates; D014151:Anti-Anxiety Agents; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid
Perifericheskiĭ mekhanizm fenomena pruvykaniia k fenibutu.