Ranitidine: a pilot study in Japan.
Twenty-four patients with gastric ulcer and 18 with duodenal ulcer diagnosed by endoscopy were treated with ranitidine, 300 mg day-1, for 8 consecutive weeks, or until the ulcer was found endoscopically healed. Of the 24 with gastric ulcer, 50% were healed within 4 weeks, and 83% within 8 weeks. Of 18 cases with duodenal ulcer, 50% were healed within 2 weeks and 94% within 4 weeks. Therapeutic effect of ranitidine was statistically significant compared with placebo. Side effects due to ranitidine administration were few and consisted of a rash in one case and slight increase of transaminase in a few patients.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D005744:Gastric Acid / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy*; D010865:Pilot Projects; D011899:Ranitidine; D013276:Stomach Ulcer / Q000188:drug therapy
D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine