Lack of effects of thallium on GABAergic mechanisms in discrete areas of the rat brain.
The effects of intramuscular treatment for 3 and 5 consecutive days with thallium sulphate (2.5, 5 and 10 mg/Kg) on GABA content, glutamate - decarboxylase (GAD) and GABA-transaminase (GABA-T) activity in different areas of the rat brain were studied. Thallium at the dose levels used did not produce significant changes in GABA content, GAD and GABA-T activity in the brain hemispheres, brainstem, hypothalamus, diencephalon and caudate nucleus.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D013793:Thallium / Q000633:toxicity*; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D013793:Thallium; D011188:Potassium