title: Quantitative structure-activity relationship in 1-substituted ureidophenoxy-3-amino-2-propanols, a class of beta-adrenergic blocking agents.
abstract: The beta-adrenergic blocking potency of 56 1-substituted ureidophenoxy-3-amino-2-propanols has been analysed in terms of the linear Free-Wilson model. The values obtained for the Free-Wilson coefficients have been correlated with the chemico-physical parameters of the substituents. The preliminary indication given by the Free-Wilson analysis has been confirmed by a quantitative regression analysis, carried out in the frame of the "mixed approach" method.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D011412:Propanolamines / Q000494:pharmacology*; D012044:Regression Analysis; D013329:Structure-Activity Relationship
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines