Deafferentation of the rat hippocampus does not alter the affinity or binding capacity for the alpha 1-adrenoceptor radioligand [125I]BE 2254.
Sectioning the dorsal afferents to the rat hippocampus led to an 88% decrease in the level of noradrenaline in the dorsal third of the structure, a 62% reduction in the medial region and no significant change in the ventral third. The lesion did not produce a change in either the affinity or maximum binding capacity of the alpha 1-adrenoceptors in any of the three regions of the hippocampus, as assessed by the binding of the radioligand [125I]BE 2254. This result indicates that reported increases in the response to noradrenaline in hippocampal slices after denervation is most likely due to a loss of noradrenaline uptake mechanisms.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D005260:Female; D006624:Hippocampus / Q000032:analysis / Q000502:physiology*; D007700:Kinetics; D009638:Norepinephrine / Q000378:metabolism; D010627:Phenethylamines / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000032:analysis / Q000378:metabolism*; D044024:Tetralones
D010627:Phenethylamines; D011942:Receptors, Adrenergic, alpha; D044024:Tetralones; C010652:BE 2254; D009638:Norepinephrine