Treatment of fibrocystic mastopathy by an antiestrogen, tamoxifen.
For three successive months, 31 patients with fibrocystic mastopathy were treated with an antiestrogen, tamoxifen. As a result, the pain subsided in all but one of them. Disappearance or marked amelioration was also noticed in the objective signs of tenderness, diffuse induration and ill-defined tender lumps. The least-affected signs were serous discharge from the nipple and well-defined tumor masses. Side effects to treatment were minimal, and benefits persisted for three months after the end of therapy in two thirds of the patients.
D000293:Adolescent; D000328:Adult; D001941:Breast Diseases / Q000188:drug therapy*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011247:Pregnancy; D013629:Tamoxifen / Q000009:adverse effects / Q000627:therapeutic use*
D010919:Placebos; D013629:Tamoxifen