Multisite intradermal antirabies vaccination. Immune responses in man and protection of rabbits against death from street virus by postexposure administration of human diploid-cell-strain rabies vaccine.
Lymphocyte transformation, production of neutralising antibody, and the development of antirabies IgG antibody were studied in ten healthy volunteers in response to 0.8 ml of human diploid-cell strain (HDCS) rabies vaccine administered on one occasion in divided doses in 8 intradermal (i.d.) sites. All ten volunteers rapidly developed substantial titres of rabies antibody, and eight of the ten had T lymphocytes that were immunologically stimulated by HDCS rabies-virus antigen. Postexposure treatment with 0.8 ml of HDCS vaccine given at 4 i.d. sites completely protected fourteen rabbits from death by street virus. The results suggest that in developing countries patients could be protected with small volumes of potent tissue-culture vaccine administered intradermally shortly after exposure.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007167:Immunotherapy; D008213:Lymphocyte Activation; D011817:Rabbits; D011818:Rabies / Q000517:prevention & control* / Q000628:therapy / Q000662:veterinary; D011819:Rabies Vaccines / Q000008:administration & dosage*; D011820:Rabies virus / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D011819:Rabies Vaccines