title: Specific IgE antibodies in twenty-eight workers with diisocyanate-induced bronchial asthma.
abstract: A specific IgE-mediated response was evaluated in twenty-eight workers exposed to TDI or MDI, with diagnosis of occupational asthma and positive to bronchial provocative challenge. The presence of anti-diisocyanate IgE was observed in 27% of subjects exposed to TDI and 83% of those exposed to MDI, particularly in individuals who experienced an acute massive exposure. An immediate-type response to bronchial provocative test was found in 66% of individuals with specific antibodies. Specific IgE are prevalent (91%) in subjects who developed symptoms before 6 years of exposure to isocyanates. The results suggest an association between the presence of specific IgE, early asthmatic symptoms and heavy episodic exposure.
mesh_terms: D001249:Asthma / Q000276:immunology*; D001985:Bronchial Provocation Tests; D003485:Cyanates / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate; D007073:Immunoglobulin E / Q000032:analysis*; D017953:Isocyanates; D008297:Male; D009784:Occupational Diseases / Q000276:immunology*; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects* / Q000276:immunology; D001559:Benzhydryl Compounds
chemical_list: D003485:Cyanates; D007073:Immunoglobulin E; D017953:Isocyanates; D014051:Toluene 2,4-Diisocyanate; C026942:2,6-diisocyanatotoluene; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds