title: [Mechanisms of synaptic transmission in the ampullae of Lorenzini in skates].
abstract: Effects of Mg2+, L-glutamate (L-GLU) and L-glutamic acid diethyl ester (GDEE) on background and evoked activity of the ampullae of Lorenzini were studied in marine skates (Raja clavata). Perfusion of the basal membrane with 10(-4)-10(-5) M L-GLU produced significant and reversible changes in background firing rate depending on its initial level. When excitability was blocked by perfusion with Mg2+, the background activity could be restored in L-GLU (10(-4)-10(-5) M) Mg2+-containing solution. GDEE (10(-3)-10(-4) M) blocked the synaptic transmission. The results are consistent with the view that L-GLU is the synaptic transmitter in the ampullae of Lorenzini of the skate.
mesh_terms: D000818:Animals; D004347:Drug Interactions; D004560:Electricity; D005399:Fishes / Q000502:physiology*; D005971:Glutamates / Q000494:pharmacology / Q000502:physiology*; D018698:Glutamic Acid; D008274:Magnesium / Q000494:pharmacology; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D005971:Glutamates; C011829:glutamic acid diethyl ester; D018698:Glutamic Acid; D008274:Magnesium
vernacular_title: Issledovanie mekhanizmov sinapticheskoĭ peredachi v ampulakh Lorentsini skatov.