Successful development of Brugia pahangi in T-cell deprived CBA mice.
CBA mice were thymectomized and treated with anti-thymocyte serum. Seven such mice were given 90--100 infective larvae of Brugia pahangi each by intraperitoneal (ip) injection and 5 given 99-100 larvae each by subcutaneous (sc) injection. From 62 days after infection 6 of 7 mice infected ip had microfilariae in their peritoneal cavities. Only one mouse infected by sc injection showed microfilariae in peripheral blood and this not until 98 days. At autopsy 5-45 adult worms were recovered from the ip infected mice. Only 2 od the 5 sc infected mice had adults and these only 3 each. No microfilariae or adult worms were detected in similarly infected unthymectomized CBA mice.
D000818:Animals; D001769:Blood / Q000469:parasitology; D002009:Brugia / Q000254:growth & development* / Q000276:immunology; D005260:Female; D005368:Filariasis / Q000276:immunology / Q000469:parasitology*; D005370:Filarioidea / Q000254:growth & development*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008842:Microfilariae / Q000254:growth & development; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy