title: Lung asbestos content in chrysotile workers with mesothelioma.
abstract: The role of chrysotile asbestos in the genesis of mesotheliomas in humans is disputed. We analyzed the asbestos content of the lung in 6 long-term chrysotile miners and millers who had pleural mesotheliomas. In five patients, only chrysotile ore components (chrysotile and tremolite/actinolite/anthophyllite types of amphibole asbestos) were found, while the sixth patient presented both chrysotile ore components and amosite, a type of asbestos that is not derived from the mining process. The mean number of fibers/g dry lung for the 5 patients with mesothelioma containing only chrysotile ore components was higher (chrysotile 64 X 10(6) and tremolite group 540 X 10(6] than in a group of long-term chrysotile miner control subjects who had no asbestos-related disease (chrysotile 23 X 10(6), tremolite group 58 X 10(6], but some patients with mesothelioma had fiber burdens near the mean of the control range. Fiber sizes and aspect ratios in the mesothelioma group were approximately the same as those in the control subjects, and analysis of fiber distribution failed to show any preferential localization in the periphery of the lung. However, the concentration ratio of tremolite in the lungs of the mesothelioma cases compared to the control cases was 9.3, while the ratio of chrysotile was only 2.8. Our findings provide strong evidence that chrysotile mine dust (chrysotile and amphibole components) can produce mesotheliomas in humans; the greater relative amounts of tremolite group amphiboles present in the patients with mesothelioma raise the possibility that these fibers may be important in the pathogenesis of the tumors.
mesh_terms: D000368:Aged; D001194:Asbestos / Q000009:adverse effects* / Q000378:metabolism*; D017636:Asbestos, Amphibole; D017632:Asbestos, Serpentine; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced / Q000378:metabolism*; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism; D009784:Occupational Diseases / Q000139:chemically induced / Q000378:metabolism*
chemical_list: D017636:Asbestos, Amphibole; D017632:Asbestos, Serpentine; D008903:Minerals; C036431:ferroactinolite; D001194:Asbestos; C005846:tremolite; C025965:anthophyllite