Interaction between ethanol and antihistamines: 3. mebhydrolin.
We used 17 student volunteers in an experiment to investigate the effects of orally administered mebhydrolin (0.71 mg/kg), alone and in combination with ethanol (0.75 g/kg), on perceptual, cognitive and motor functions. Mebhydrolin did not significantly modify performance when given alone, but showed evidence of enhancing ethanol-induced performance deficits. Histamine challenge experiments indicated that the dose of mebhydrolin used exerted an antihistaminic effect over the period of the ethanol interaction study.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002243:Carbolines / Q000378:metabolism / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010465:Perception / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects
D002243:Carbolines; D006634:Histamine H1 Antagonists; D007211:Indoles; D000431:Ethanol; C005139:mebhydroline