[Comparative analysis of immunoreactive indices in malignant and benign bone tumors].
The paper discusses the results of a study of immunologic surveillance in patients with bone tumors. T-lymphocyte deficiency was found in 21-32% of cases only, while all patients showed changes in the level of some T-cell subpopulations and their ratio. Patients with malignant tumors (mostly osteosarcoma) revealed a lowered response to PHA and a high frequency of sensitization to tumor antigens. In those cases, serum, blood--circulating T-cells and tumor--infiltrating lymphocytes showed a suppressor activity. A moderately decreased response to PHA, a low frequency of sensitization to tumor antigens and a stimulating activity in serum, blood--circulating T-cells and lymphocytes were registered in cases of benign tumors (mainly giant cell tumors). Suppressor activity of blood T-lymphocytes was matched by a high level of TG cells, while stimulating effect--by a low one.
D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000276:immunology; D001859:Bone Neoplasms / Q000276:immunology*; D002464:Cell Migration Inhibition; D002804:Chondroblastoma / Q000276:immunology; D002812:Chondroma / Q000276:immunology; D005350:Fibroma / Q000276:immunology; D005870:Giant Cell Tumors / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D010017:Osteoma, Osteoid / Q000276:immunology; D012516:Osteosarcoma / Q000276:immunology; D013584:Sarcoma, Synovial / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology
D000951:Antigens, Neoplasm
Sravnitel'nyĭ analiz pokazateleĭ immunologicheskoĭ reaktivnosti pri zlokachestvennykh i dobrokachestvennykh opukholiakh kosteĭ.