[Effect of lithium hydroxybutyrate and lithium chloride on heart rhythm disorders of various origins].
It has been shown in experiments on anesthetized cats and dogs that lithium hydroxybutyrate produces antiarrhythmic action in central aconitic and strophanthine arrhythmias, prevents the development of ventricular fibrillation, and shows antiarrhythmic activity in strong occlusion on the coronary artery. The drug does not remove the atrial and aconitic patterns of arrhythmia. Lithium chloride also exhibits antiarrhythmic action in central aconitic arrhythmia, being inferior to lithium hydroxybutyrate. The drug does not influence central strophanthine arrhythmia and does not show antifibrillation activity.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002415:Cats; D002712:Chlorides / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D005260:Female; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008094:Lithium / Q000627:therapeutic use*; D018021:Lithium Chloride; D008297:Male; D009942:Organometallic Compounds; D011342:Procainamide / Q000627:therapeutic use; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D002712:Chlorides; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium; D018021:Lithium Chloride; D011342:Procainamide
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