Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes.
Using a combination of classical genetics, serology, and molecular genetics, we have mapped as many as possible of the MHC components in t haplotypes. Results indicate that the whole MHC is included in a simple inversion with the relative positions of its genes being intact. Furthermore, some of the t-lethal mutations map very near to, or are intermingled with, components of the MHC. At the centromeric end the t12 lethal maps between TL and H-2D in the Qa region, and distally the tw5 lethal is inseparable from H-2K.
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003602:Cytotoxicity, Immunologic; D004262:DNA Restriction Enzymes; D005260:Female; D005804:Genes, Lethal; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D007106:Immune Sera; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009693:Nucleic Acid Hybridization; D011995:Recombination, Genetic
D006183:H-2 Antigens; D007106:Immune Sera; D004262:DNA Restriction Enzymes