[Propafenon-induced cholestatic liver injury--a further example for allergic drug hepatitis (author's transl)].
In the course of cholestatic liver injury after propafenonhydrochloride medication, a high increase of the glutamatedehydrogenase up to the twenty fold of the normal range was followed by a marked raise of SGOT and SGPT. Cholestatic enzymes like gamma-glutamyl transpeptidase and alkaline phosphatase reached their maxima a week later. Within two weeks the hepatic cell enzymes and within four weeks the cholestatic enzymes have returned spontaneously to normal.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002779:Cholestasis / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000473:pathology*; D006801:Humans; D008297:Male; D011405:Propafenone; D011427:Propiophenones / Q000009:adverse effects*; D005723:gamma-Glutamyltransferase / Q000097:blood
D000319:Adrenergic beta-Antagonists; D011427:Propiophenones; D011405:Propafenone; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
Propafenon-induzierte cholestatische Hepatitis. Ein weiteres Beispiel für eine medikamentös induzierte "allergische" Leberschädigung.