Beta-endorphin and somatostatin in the pancreatic D-cell colocalization by immunocytochemistry.
Utilizing highly specific antisera, beta-endorphin and somatostatin immunoreactivity were identified simultaneously in the D-cell of the pancreas of the rat, guinea pig, and man by the fluorescence-immunocytochemical technique. Our observations are consistent with a modulating role of beta-endorphin either within the D-cell or upon A and B cells, thereby regulating the secretion of insulin and glucagon.
D000818:Animals; D004723:Endorphins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology*; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000032:analysis*; D013045:Species Specificity
D004723:Endorphins; D013004:Somatostatin