Intubation conditions and reversibility of a new non-depolarizing neuromuscular blocking agent, Org-NC45.
We describe the clinical use, for intubation purposes, of Org-NC45, a new non-depolarizing neuromuscular blocking agent. Administration of 50 and 72 microgram/kg of this drug allowed good to excellent endotracheal intubation conditions within 3 and 2 min, respectively. In none of the cases ws a significant change in blood pressure or heart rate seen after the injection of Org-NC45. The resulting block was of short duration and, if necessary, was easily reversed with neostigmine or pyridostigmine.
D000328:Adult; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D009388:Neostigmine / Q000494:pharmacology; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D011729:Pyridostigmine Bromide / Q000494:pharmacology; D013997:Time Factors; D014673:Vecuronium Bromide
D003473:Neuromuscular Nondepolarizing Agents; D009388:Neostigmine; D014673:Vecuronium Bromide; D010197:Pancuronium; D011729:Pyridostigmine Bromide