Role of immunity in age-related resistance to paralysis after murine leukemia virus infection.
Resistance to the paralytic effects of a wild mouse (Cas-Br-M) murine leukemia virus infection develops with age and is complete by 10 days of age in susceptible NFS mice. The possibility that cell-mediated immunity plays a significant role in this resistance was suggested by the observation that treatment of 10-day-old mice with antithymocyte serum rendered them susceptible to paralysis. By comparison, mice rendered incapable of generating a humoral immune response by treatment from birth to 1 month of age with anti-immunoglobulin M serum did not develop paralysis after challenge with virus at day 10. Transfer of unseparated and T-cell-enriched populations of Cas-Br-M murine leukemia virus-immune spleen cells protected neonatally infected NFS recipients from paralysis; transfer of Cas-Br-M murine leukemia virus-immune populations enriched for B cells delayed the onset but did not ultimately protect neonatally infected NFS mice from paralysis. Transfer of naive adult spleen cells had no protective effect in neonatally infected NFS mice. High-level virus replication occurred in the spleens and brains of all mice that developed paralysis regardless of treatment; low-level virus replication in spleen and barely detectable replication in brain occurred in mice that remained clinically normal. These studies suggest that the age-acquired resistance to the paralytic effect of Cas-Br-M murine leukemia virus infection is immunologically mediated and that T cells may play a major role.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology* / Q000382:microbiology; D000914:Antibodies, Viral / Q000032:analysis; D000961:Antilymphocyte Serum; D001921:Brain / Q000382:microbiology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010243:Paralysis / Q000382:microbiology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication
D000914:Antibodies, Viral; D000961:Antilymphocyte Serum; D014764:Viral Proteins