Separation of drinking and pressor responses to central angiotensin by monoamines.
This study investigated the neurotransmitters involved in the increase in blood pressure and drinking produced when angiotension II is injected intraventricularly (ivt). Using pharmacologic manipulations of the monoamines norepinephrine, dopamine, and serotonin it has been possible to separate the pressor response from dipsogenic responses to angiotension II. Alpha-adrenergic blockade with phentolamine restricted to the brain blocked the pressor response to angiotensin II in a dose-related manner, while drinking remained unaffected. Norepinephrine alone, injected into the ventricles elevated blood pressure, but did not produce drinking. The norepinephrine effect was also blocked by phentolamine by the same ventricular route. Other monoamines were not involved. Dopamine alone did not produce thirst. Cardiovascular effects with dopamine were observed only with large doses. The dopaminergic agonist apomorphine produced no change in blood pressure or drinking. Reduction of central serotonin stores by p-chlorophenylalanine intraperitoneally or 5,7-dihydroxytryptamine intraventricularly had no effect on the pressor or dipsogenic effects of angiotensin II. The serotonin agonist N,N-dimethyl-5-methoxytryptamine ivt did not produce a rise in blood pressure or drinking. It is concluded that the pressor effect of angiotensin II, but not the drinking effect is mediated by noradrenergic stimulation of alpha-receptors. The drinking response does not appear to be mediated by the monoamines.
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001794:Blood Pressure; D001921:Brain / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D004326:Drinking; D007276:Injections, Intraventricular; D008297:Male; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology
D018377:Neurotransmitter Agents; D000804:Angiotensin II; D012701:Serotonin; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine; D010646:Phentolamine