Effects of vitamin D3 on in vivo labelling of chick skeletal muscle proteins with [3H]leucine.
The effects of the administration of a single oral dose of vitamin D3 to rachitic chicks on the in vivo incorporation of [3H]leucine to proteins of skeletal muscle subcellular fractions was studied. A significant stimulation (50%) of labelling of mitochondrial proteins could be seen. The sterol affected the labelling of sarcoplasmic reticulum (20%) and contractile proteins (10%) to a lesser extent. These results confirm previous observations which implicate vitamin D3 in the synthesis of mitochondrial proteins.
D000818:Animals; D002645:Chickens; D002762:Cholecalciferol / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D014176:Protein Biosynthesis; D014316:Tritium; D014808:Vitamin D Deficiency / Q000378:metabolism
D014316:Tritium; D002762:Cholecalciferol; D007930:Leucine