title: Association of beta hydroxybutyric acidosis with isoniazid intoxication.
abstract: Acute metabolic acidosis associated with accumulation of lactate has been previously reported in isoniazid (INH) intoxication. To our knowledge, association of INH toxicity with beta-hydroxybutyric acidosis has not been demonstrated previously. The present report documents the occurrence of beta-hydroxybutyric acidosis in patients with INH intoxication. The reason for the lack of previous reports of this association is not clear, although failure to measure plasma beta-hydroxybutyrate levels in previous studies is a likely possibility. Our patients received intravenous sodium bicarbonate, anticonvulsants and dialysis which resulted in complete reversal of metabolic acidosis and other manifestations of INH toxicity.
mesh_terms: D020155:3-Hydroxybutyric Acid; D000138:Acidosis / Q000139:chemically induced* / Q000628:therapy; D000328:Adult; D001639:Bicarbonates / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates; D007538:Isoniazid / Q000506:poisoning*; D008297:Male; D011736:Pyridoxine / Q000627:therapeutic use; D006435:Renal Dialysis; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D006885:Hydroxybutyrates; D017693:Sodium Bicarbonate; D011736:Pyridoxine; D003975:Diazepam; D020155:3-Hydroxybutyric Acid; D007538:Isoniazid