Once daily beta-adrenoceptor blockade in hypertension: an ambulatory assessment.
1 The ambulant intra-arterial blood pressure of eighteen hypertensive subjects was monitored before and again after 3 months treatment with thrice daily sotalol (six patients), twice daily pindolol (six patients) and once daily pindolol (six patients). 2 Three patients in the sotalol group underwent a third study having changed to a once daily regimen; similarly six patients in the pindolol groups were restudied having crossed over to the alternative pindolol dosing regimen, total daily dosage being maintained in all cases. 3 Comparison of 24 h blood pressure curves before and after treatment showed effective daytime reduction but less consistent effects at night. 4 In the crossover experiments once daily and multiple daily dosing regimens produced identical patterns of reduction over 24 h in both blood pressure and heart rate. 5 It is inferred that in the treatment of hypertension, once daily dosing with standard preparations of beta-adrenoceptor blocking agents is probable adequate.
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D000328:Adult; D000553:Ambulatory Care; D001794:Blood Pressure / Q000187:drug effects; D004334:Drug Administration Schedule; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D013997:Time Factors
D000319:Adrenergic beta-Antagonists