Oncogenecity of an avian erythroblastosis virus in mutant strains of Japanese quails.
The susceptibility of 12 mutant strains of Japanese quails to the R strain of avian erythroblastosis virus (AEV) was examined. Three strains, SBPP, PNN and CWE, showed high susceptibility and developed various types of tumors including erythroblastosis, hemangioma and myeloblastic leukemia. In relatively resistant WE strain, increased incidence and various types of tumors were observed by modification of host conditions. These results indicate pluripotential oncogenicity of AEV in quails as well as partial control of AEV-oncogenesis by genetical background of the host.
D001355:Alpharetrovirus / Q000472:pathogenicity*; D000818:Animals; D001353:Avian Leukosis / Q000382:microbiology*; D001354:Avian Leukosis Virus / Q000472:pathogenicity*; D003370:Coturnix / Q000235:genetics / Q000382:microbiology*; D004198:Disease Susceptibility; D004625:Embryo, Nonmammalian; D015470:Leukemia, Myeloid, Acute / Q000382:microbiology; D009154:Mutation; D011784:Quail / Q000382:microbiology*