title: Abrupt withdrawal of chronic beta-blockade: adaptive changes in cyclic AMP and contractility.
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010096:Oxprenolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
chemical_list: D000319:Adrenergic beta-Antagonists; D010096:Oxprenolol; D000242:Cyclic AMP; D008790:Metoprolol; D007545:Isoproterenol