Evidence for alpha-adrenergic receptors mediated TSH release in men.
In order to elucidate the role of the adrenergic nervous system in the mechanism of TSH release in men the effects of alpha- and beta-receptors blocking agents were studied in 11 healthy volunteers. Phentolamine administered iv as a bolus injection in a dose of 10 mg, significantly lowered the TSH release in basal condition and in response to TRH stimulation. However, propranolol in a dose of 0.1 mg/kg administered in the same fashion as phentolamine had no effect on the TSH secretion. The results obtained suggest that the alpha-receptors of the adrenergic system are involved in the physiological mechanism which stimulates TSH release in men.
D000293:Adolescent; D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013972:Thyrotropin / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D014284:Triiodothyronine; D013972:Thyrotropin; D011433:Propranolol; D013974:Thyroxine; D010646:Phentolamine