title: A contribution to the study of the regulatory system of local immune response in "Gallus domesticus".
abstract: The "priming effect" is studied to ascertain whether a regulatory system of local immune response exists and, if it does, what its function is. Bursectomized, bursa-ligated and silica-treated chicks were used, together with control birds (silica selectively damages the follicle associated epithelial -FAE- cells). Agglutinins and direct plaque forming cells (PFC)/spleen were checked. The results confirm that contact between the antigen and the bursal tissue acts as a primary stimulus for immune response and that extrabursal lymphoid sites are unable to act in the same way as the bursa of Fabricius. It seems quite probable, then, that a regulatory system of local immune response exists.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002060:Bursa of Fabricius / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006388:Hemagglutinins / Q000032:analysis; D007107:Immune System / Q000187:drug effects / Q000276:immunology*; D008297:Male; D012822:Silicon Dioxide / Q000494:pharmacology; D013154:Spleen / Q000276:immunology
chemical_list: D006388:Hemagglutinins; D012822:Silicon Dioxide