Identification of carcinoembryonic antigen in the C-cell of the normal thyroid.
Carcinoembryonic antigen (CEA) activity was confirmed in the C-cell of the normal thyroid by immunohistochemical techniques. This suggests that CEA production in medullary carcinoma of the thyroid is not initiated by carcinogenesis, but reflects a function of the normal C-cell. It is not yet clear whether CEA production in the C-cell may be influenced by carcinogenesis. The C-cell is the first APUD cell that was confirmed to have CEA activity.
D001078:APUD Cells / Q000276:immunology; D002272:Carcinoembryonic Antigen; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000166:cytology / Q000276:immunology*; D013964:Thyroid Neoplasms / Q000209:etiology / Q000276:immunology
D002272:Carcinoembryonic Antigen