Effect of aceclidine(+) isomer and pilocarpine on the intraocular pressure decrease and the miosis in glaucomatous eyes. Effect on accommodation in normal eyes of young subjects.
Previous studies demonstrated that the (+) isomer of aceclidine has a stronger cholinergic effect than pilocarpine or the racemic mixture of aceclidine. The effect of aceclidine(+) and pilocarpine on the intraocular pressure and the sphincter pupillae in patients suffering from open angle glaucoma, and on the accommodation in normal young subjects, was studied. The results demonstrated a similar effect of both drugs. The discrepancy between the cholinergic potential of the drugs and their effect in the eye is discussed.
D000065:Accommodation, Ocular / Q000187:drug effects*; D000328:Adult; D001082:Aqueous Humor / Q000502:physiology; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D010277:Parasympathomimetics; D010862:Pilocarpine / Q000494:pharmacology / Q000627:therapeutic use*; D011680:Pupil / Q000187:drug effects; D011812:Quinuclidines / Q000494:pharmacology / Q000627:therapeutic use*; D013237:Stereoisomerism
D010277:Parasympathomimetics; D011812:Quinuclidines; D010862:Pilocarpine