Effect of cholecystokinin octapeptide on ethanol intake in the rat.
Water-deprived rats received 3%, 6% or 9% ethanol solution or water for 30 min daily. Intraperitoneal injection of cholecystokinin octapeptide (CCK-8, 2.0-4.0 micrograms/kg) significantly and specifically inhibited ethanol intake. The findings are consistent with previous reports of specificity of the inhibition of caloric intake by CCK-8. Administration of CCK-8 may influence ethanol intake by modulating a satiety signal that ordinarily controls ethanol intake.
D000428:Alcohol Drinking; D000818:Animals; D003864:Depression, Chemical; D004327:Drinking Behavior / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012528:Satiety Response / Q000187:drug effects; D012844:Sincalide / Q000494:pharmacology*; D014867:Water; D014868:Water Deprivation
D014867:Water; D012844:Sincalide