Shigella sonnei endotoxin reduces arterial blood pressure but does not alter pituitary pro-opiocortin cleavage and corticosterone release in the rat.
Intravenous (iv) bolus injection of 320 and 640 micrograms/Kg of lipopolysaccharides (LPS) of S. sonnei (either in phase I or in phase II) resulted in a dose-dependent decrease in mean arterial pressure, when given in freely moving rats. No changes were observed in plasma beta-endorphin (beta-EP), ACTH and corticosterone levels. Pituitary beta-EP content was not modified 1 h after iv injection of LPS. Data suggest that doses of LPS, which are able to produce reversible hypotension, do not alter pro-opiocortin cleavage and corticosterone release.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001794:Blood Pressure; D003345:Corticosterone / Q000378:metabolism*; D004723:Endorphins / Q000097:blood; D004731:Endotoxins / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012764:Shigella sonnei; D013997:Time Factors; D001615:beta-Endorphin
D004723:Endorphins; D004731:Endotoxins; D008070:Lipopolysaccharides; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone