Influence of cholinomimetics and cholinolytics on vestibular compensation.
The influence of cholinomimetics and cholinolytics on vestibular compensation was investigated in Rana temporaria. In compensated animals cholinomimetics induced a complete decompensation with reappearance of all symptoms characteristic of the precompensated state. Cholinolytic exerted antagonistic effects. They induced postural and locomotor symptoms which were a mirror-image of those observed in the precompensated state. The findings support the assumption that the compensatory reorganization of the vestibular system involves the modification of cholinergic brain stem synapses.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D007758:Ear, Inner / Q000502:physiology; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology*; D009116:Muscarine / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology*; D010095:Oxotremorine / Q000494:pharmacology*; D011896:Rana temporaria; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000502:physiology*
D001626:Bethanechol Compounds; D008688:Methacholine Compounds; D018723:Bethanechol; D016210:Methacholine Chloride; D001115:Arecoline; D010095:Oxotremorine; D009538:Nicotine; D009116:Muscarine; D002217:Carbachol