Assessing pharmacologically induced dopamine receptor sensitivity changes with the Ungerstedt turning model.
Rats were lesioned unilaterally in the substantia nigra with 6-hydroxydopamine. Turning in response to apomorphine and amphetamine was assessed before and 5 days after 3-week treatment with haloperidol. After haloperidol withdrawal, contralateral turning, measured at 5 min following IP injection of 1 mg/kg apomorphine, was significantly less than before haloperidol treatment and ipsilateral turning, measured at 30 min following IP injection of 2 mg/kg amphetamine, was significantly greater than before the haloperidol treatment. These results suggest that dopamine receptor sensitivity increased on the unlesioned side compared to the lesioned side.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D008954:Models, Biological; D016627:Oxidopamine; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D012399:Rotation
D014150:Antipsychotic Agents; D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D016627:Oxidopamine; D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine