title: Epstein-Barr virus and chronic lymphadenomegaly in male homosexuals with acquired immunodeficiency syndrome (AIDS).
abstract: Male homosexuals at risk for developing AIDS frequently exhibit chronic lymphadenomegaly (LAD). They are at high risk for developing malignant B cell lymphomas. A study of Epstein-Barr virus (EBV) revealed marked abnormalities in these patients. One hundred percent of the patients were seropositive. The patients with most severe acquired immune deficiency disorders manifested a decreased number of circulating B cells with EBV receptors and decreased lymphocyte transformation. Patients often showed defective memory T cell cytotoxic responses to autologous EBV infection in vitro. Three of five lymph node specimens contain significant EBV genome copies to suggest a significant etiologic role. In addition, a Burkitt-like lymphoma carried EBV genome. Although all of the men were seropositive for EBV, reactivation patterns were not as common as anticipated. Given the presence of EBV genome in the lymph nodes of the patients who lack anti-early antigen (EA) antibodies indicative of reactivation, we suggest that reliance on serology to indicate EBV involvement is insufficient for assessing the patient. The detection of a t(8;14) transposition in the monoclonal mu kappa Burkitt-like lymphoma containing EBV genome supports the view that cytogenetic transposition is a mechanism in lymphomagenesis.
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000382:microbiology*; D000914:Antibodies, Viral / Q000032:analysis; D002869:Chromosome Aberrations; D002908:Chronic Disease; D004279:DNA, Viral / Q000032:analysis; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity*; D006716:Homosexuality; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008206:Lymphatic Diseases / Q000209:etiology / Q000382:microbiology*; D008223:Lymphoma / Q000209:etiology; D008297:Male; D009693:Nucleic Acid Hybridization; D017464:Receptors, Complement 3d; D011991:Receptors, Virus / Q000032:analysis
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007136:Immunoglobulins; D017464:Receptors, Complement 3d; D011991:Receptors, Virus