Antagonism of diazepam-induced feeding in rats by antisera to opioid peptides.
Diazepam-induced feeding in rats is antagonized not only by the opiate antagonist naloxone but also intraventricular administration of specific antisera to the endogenous opioid peptides met-enkephalin or beta-endorphin. Pituitary beta-endorphin is probably not implicated in the diazepam effect since blockade with the glucocorticoid dexamethasone of the release of beta-endorphin from the anterior pituitary does not modify the diazepam-induced feeding, which is however prevented by TRH, a suggested physiological antagonist of some of the effects of opioid peptides. The possible central participation of both beta-endorphin and met-enkephalin in the ingestive behavior induced by diazepam gives further support to the postulated physiological role of endogenous opioids in appetite regulation.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D003975:Diazepam / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D004744:Enkephalin, Methionine / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D001615:beta-Endorphin
D004723:Endorphins; D007106:Immune Sera; D009270:Naloxone; D004744:Enkephalin, Methionine; D009271:Naltrexone; D013973:Thyrotropin-Releasing Hormone; D001615:beta-Endorphin; D003907:Dexamethasone; D003975:Diazepam