title: Gene enrichment in an American Indian population: an excess of severe combined immunodeficiency disease.
abstract: A subgroup of Athabascan Indians in Arizona and New Mexico was found to have an unusually high incidence of severe combined immunodeficiency, probably due to founder effect. Closed genetic pressures have limited their histocompatibility-antigen heterogeneity, enabling 3 patients to be grafted, 2 of them across HLA-B locus barriers.
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology; D001130:Arizona; D002675:Child, Preschool; D003241:Consanguinity; D005260:Female; D005787:Gene Frequency; D005808:Genes, Recessive; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology; D007198:Indians, North American; D008297:Male; D009516:New Mexico
chemical_list: D006680:HLA Antigens