[Fundamental study of ceftriaxone in the field of obstetrics and gynecology].
Excretion of ceftriaxone (Ro 13-9904, CTRX) into female genital organs was studied by determining its concentration in the dead space exudate of the patients who received radical hysterectomy due to uterocervical cancer. Data analysis was performed by the three-compartment model. The serum peak level of CTRX in the cubital vein was 177.74 micrograms/ml 1 hour after the initiation of intravenous drip infusion for 1 hour with 1 g. The concentration of CTRX in the exudate of pelvic dead space reached a peak of 62.75 micrograms/ml 4.61 hours after the start of administration and still showed a very high level of 25 micrograms/ml at 24 hours. The AUC of the excretion into the exudate of pelvic dead space was 1,432.43 micrograms X hr/ml. These results indicate that CTRX is a clinically useful drug, being excreted into the exudate of pelvic dead space favorably.
D001419:Bacteria / Q000187:drug effects; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D002443:Ceftriaxone; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008954:Models, Biological; D010388:Pelvis / Q000378:metabolism; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000378:metabolism
D002443:Ceftriaxone; D002439:Cefotaxime