Some patients with cerebral aneurysms are deficient in type III collagen.
Polyacrylamide gel electrophoresis of pepsin-digested skin biopsy specimens and carboxymethyl cellulose chromatography of radioactively labelled collagens produced by cultured fibroblasts demonstrated that 7 of 12 patients with congenital cerebral aneurysms were type III collagen deficient. This suggests that some cerebral aneurysms resemble various inherited defects of connective tissue-i.e., Ehlers-Danlos syndrome type IV-in which type III collagen deficiency causes arterial fragility.
D002543:Cerebral Hemorrhage / Q000209:etiology; D003094:Collagen / Q000145:classification / Q000172:deficiency* / Q000235:genetics; D006801:Humans; D002532:Intracranial Aneurysm / Q000151:congenital* / Q000209:etiology / Q000235:genetics
D003094:Collagen