Studies on arterial mineralocorticoid and glucocorticoid receptors: evidence for the translocation of steroid-cytoplasmic receptor complexes to cell nuclei.
The high affinity binders for mineralocorticoids and glucocorticoids, previously reported by us as present in arterial cytosol have been further characterized. The results of this study demonstrate that these binders translocate under appropriate conditions to cell nuclei as complexes with mineralocorticoids and glucocorticoids, respectively. Thus, they exhibit a fundamental property of steroid receptors. This provides evidence for the presence in the arterial wall of a molecular mechanism(s) for the in-situ action of both mineralocorticoids and glucocorticoids.
D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001158:Arteries / Q000378:metabolism*; D001667:Binding, Competitive; D001692:Biological Transport; D002467:Cell Nucleus / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003900:Desoxycorticosterone / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D006854:Hydrocortisone / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D011374:Progesterone / Q000378:metabolism; D011817:Rabbits; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D011987:Receptors, Steroid; D003900:Desoxycorticosterone; D000450:Aldosterone; D011374:Progesterone; D003907:Dexamethasone; D003345:Corticosterone; D006854:Hydrocortisone