Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation.
Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement. Dilatation by a balloon-tipped catheter produced an immediate and sustained reversal of the arteriospasm, together with a dramatic relief of symptoms and signs.
D000328:Adult; D001132:Arm / Q000098:blood supply; D001158:Arteries / Q000187:drug effects*; D002404:Catheterization / Q000379:methods; D004106:Dilatation / Q000295:instrumentation / Q000379:methods*; D004878:Ergotamine / Q000009:adverse effects* / Q000506:poisoning; D005260:Female; D005734:Gangrene / Q000517:prevention & control; D006801:Humans; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D013035:Spasm / Q000139:chemically induced / Q000628:therapy*
D004878:Ergotamine