Imaging of soft tissue tumors with Tc(V)-99m dimercaptosuccinic acid. A new tumor-seeking agent.
Tumor scintigraphy, using Tc(V)-99m dimercaptosuccinic acid (Tc(V)-DMS) was performed in 58 patients with soft tissue tumors, and the results were compared with that of Ga-67 citrate. Tc(V)-DMS was found to have a sensitivity of 90% for malignant tumors including aggressive fibromatosis compared to that of Ga-67 citrate, which was 56%. However, the specificity of Tc(V)-DMS for these tumors was 71% but with Ga-67 citrate the specificity was 80%. The imaging accuracy in soft tissue tumors with Tc(V)-DMS and Ga-67 citrate was 78% and 71%, respectively. Although the accumulation of Tc(V)-DMS has been detected in some benign soft tissue tumors, the reduced accumulation in inflammatory lesions compared to Ga-67 citrate was recognized, and Tc(V)-DMS could be of great use in the detection of extension or location of malignant soft tissue tumors.
D000038:Abscess / Q000000981:diagnostic imaging; D000328:Adult; D000368:Aged; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005350:Fibroma / Q000000981:diagnostic imaging; D005710:Gallium Radioisotopes; D018219:Histiocytoma, Benign Fibrous / Q000000981:diagnostic imaging; D006801:Humans; D008067:Lipoma / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000000981:diagnostic imaging; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging*; D004113:Succimer; D013438:Sulfhydryl Compounds; D013585:Synovitis / Q000000981:diagnostic imaging; D013667:Technetium; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
D005710:Gallium Radioisotopes; D013438:Sulfhydryl Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013667:Technetium; D004113:Succimer