Effect of carbon monoxide exposure on heart cytochrome c oxidase activity of rats.
The activity of cytochrome c oxidase in heart muscle of rats was within the control range 1 and 24 h after commencement of CO exposure (56% COHb) and was significantly decreased 3 h thereafter. A decrease of the enzyme activity was also detectable 3 h following repeated CO exposure demonstrating that cytochrome c oxidase does not seem to play a role in the adaptive response of organism to chronic CO exposure.
D000818:Animals; D002248:Carbon Monoxide / Q000633:toxicity*; D002263:Carboxyhemoglobin / Q000032:analysis; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D003576:Electron Transport Complex IV