[Functional state of rat liver mitochondria in experimental peritonitis].
Respiration and oxidative phosphorylation were studied in liver mitochondria of rats with experimental peritonitis. Peritonitis did not cause any distinct alterations in the functional state of liver mitochondria. Activity of main mitochondrial enzymes was only slightly altered. Inactivation of metabolic toxins occurred in cytoplasm of hepatocytes, i. e. out of mitochondria. Addition of peritoneal exudate at various dilutions to intact isolated mitochondria caused uncoupling of respiration and oxidative phosphorylation.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D010538:Peritonitis / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases
Funktsional'noe sostoianie mitokhondriĭ pecheni krys pri éksperimental'nom peritonite.