title: The effect of bucolome on the blood circulation of splanchnic organs in rats with and without pentobarbitone anesthesia.
abstract: Using carbonized microspheres, either 15 microns or 50 microns in diameter and labeled with 85Sr, 51Cr or 141Ce, the effect of bucolome (1-cyclohexyl-5-n-butyl-2-, 4, 6-trioxoperhydropyrimidine), a non-steroid anti-inflammatory agent and potent choleretic, on the splanchnic blood circulation was studied in rats with and without pentobarbitone sodium anesthesia. Pentobarbitone sodium caused a significant increase in the distribution of cardiac output in the major splanchnic organs, in particular in the small and large intestines. An i.p. injection of bucolome (20 mg/100 g) produced a significant increase in the cardiac output distribution in the small intestine, and a significant decrease in the pancreatic fraction in both rat groups with and without pentobarbitone anesthesia, in spite of the large increase in the base-line values caused by anesthesia.
mesh_terms: D000758:Anesthesia; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D013152:Splanchnic Circulation / Q000187:drug effects*
chemical_list: D001463:Barbiturates; D010424:Pentobarbital