Comparative study on the inhibitory effect of rimantadine on the reproduction of epidemic strains of influenza A virus H3N2 and H1N1.
The sensitivity to rimantadine of the reproduction of influenza virus A/Texas/1/77 (H3N2) and A (H1N1) isolates Nos 897, 778 and 782, isolated from patients during an epidemic influenza outbreak in Moscow in the winter of 1977/1978 was compared. A (H3N2) virus proved to be more sensitive than the A (H1N1) viruses tested, as manifested by decreases of the infectious titre in ovo and of the haemagglutinin titre in MDCK cells.
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D004285:Dogs; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D012299:Rimantadine / Q000494:pharmacology*
D012299:Rimantadine; D000218:Adamantane