Digitalis: new aspects of pharmacokinetics and clinical implications.
Any evaluation of the efficacy of digoxin therapy must rely upon a precise index of the digitalization status. As the plasma concentrations bear a rather poor relationship with clinical effects of treatment, the occupied fraction of digoxin receptors (Na-K ATPase) on the erythrocytes membranes is proposed as a new index of digitalization status; preliminary data on the value of this approach are discussed.
D004071:Digitalis Glycosides / Q000097:blood / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000032:analysis / Q000378:metabolism; D007700:Kinetics; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D004071:Digitalis Glycosides; D007473:Ion Channels; D000254:Sodium-Potassium-Exchanging ATPase