Effect of simultaneous administration of vitamin E and pyridoxine on erythrocyte membrane Na+K+ ATPase activity.
Vitamin E is known to have an interaction with pyridoxine. To understand the functional significance of this interaction a study was carried out on the effect of simultaneous administration of vitamin E and pyridoxine on erythrocyte membrane Na+K+ ATPase activity. Adult male volunteers belonging to low socio-economic class with prior consent were used as subjects for the study. The results of the study have shown that administration of vitamin E alone brings about a transient increase in the total and ouabain insensitive Na+K+ ATPase. Administration of B6 along with vitamin E brought about an increase in the total and true Na+K+ ATPase activity. B6 administration alone showed a statistically insignificant increase in true ATPase activity. The results of the study are interpreted to show that administration of vitamin E along with B6 is beneficial to membrane function.
D004347:Drug Interactions; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D011736:Pyridoxine / Q000494:pharmacology*; D012959:Socioeconomic Factors; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D011736:Pyridoxine