[Implantation and deciduation process after the action of the antihistamine preparation diprazin in early rat embryogenesis].
A histological and historadioautographical analysis of the uterine endometrium decidual tissue on the 5th, 6th, 7th and 8th days of pregnancy has shown that diprasin affects the processes of proliferation and differentiation of decidual cells, thus delaying the embryo's implantation. Deviations in the zonal division of decidual cells by their mitotic activity were found at all stages studied. The second (from the embryo) zone and mesometral part of deciduoma which are cambial regions proved to be the most sensitive. The data obtained suggest that the delay in embryonic development after the effect of diprasin is due to serious changes in deciduolization of endometrium.
D000818:Animals; D001345:Autoradiography; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003656:Decidua / Q000187:drug effects*; D010064:Embryo Implantation / Q000187:drug effects*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D011247:Pregnancy; D011398:Promethazine / Q000494:pharmacology*; D051381:Rats
D006634:Histamine H1 Antagonists; D011398:Promethazine
Izuchenie protsessa implantatsii i detsiduolizatsii posle deĭstviia antigistaminnogo preparata diprazina v rannem émbriogeneze krys.