The relative importance of genetic and environmental factors in hypertension in black subjects.
Essential hypertension is the most important cardiovascular disease in black subjects. The types of presentation, the pattern of organ involvement and the subsequent complications are similar in black races. The response (or lack of response) to different types of treatment are also alike in blacks when compared with caucasians. Striking racial differences are observed in the plasma and intracellular electrolytes, cation transmembrane transport, salt taste threshold, plasma renin activity and urinary kallikrein activity. The similarities within the black racial groups are very likely to be genetic, although the pattern of inheritance remains controversial. Differences, however, occur in the prevalence and severity of the disease among the black racial groups. That these differences are due partly to environmental causes can not be disputed because even within the same ethnic groups changing patterns are observed in the prevalence of hypertension, in the course of urbanization of rural communities, or on moving from a previously rural to an urban environment. Consequently, genetic factors may be the only important considerations in the severity of hypertension in black subjects.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000349:Africa; D001741:Black or African American; D000959:Antihypertensive Agents / Q000627:therapeutic use; D044383:Black People; D003647:Debrisoquin / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004573:Electrolytes / Q000097:blood; D004777:Environment; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics*; D007610:Kallikreins / Q000652:urine; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D012083:Renin / Q000097:blood; D014507:Urbanization; D044465:White People
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D004232:Diuretics; D004573:Electrolytes; D008750:Methyldopa; D007610:Kallikreins; D012083:Renin; D003647:Debrisoquin