[Spectra of pharmacological activity of the endogenous ligands of the benzodiazepine receptors and their structural analogs].
Psychopharmacological methods were used to study and compare the effects of diazepam and ligands of benzodiazepine receptors (inosin, nicotinamide and their structural analogs NMF and AzN) in animal experiments. It was found that they possess demonstrable sedative, anticonvulsant, antiaggressive and myorelaxant properties, inhibit the conditioned avoidance reflex in a shuttle-box and the conditioned reflex with positive (drinking) reinforcement in a T-maze. The structural analogs of nicotinamide, NMF and AzN, were found to occupy the intermediate position between diazepam and endogenous ligands of benzodiazepine receptors from the standpoint of pharmacological activity.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D006801:Humans; D007288:Inosine / Q000031:analogs & derivatives / Q000494:pharmacology; D008024:Ligands; D008297:Male; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*
D008024:Ligands; D011619:Psychotropic Drugs; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D009536:Niacinamide; D007288:Inosine; D003975:Diazepam
Spektry farmakologicheskoĭ aktivnosti éndogennykh ligandov benzodiazepinovykh retseptorov i ikh strukturnykh analogov.