An interaction of testosterone with cell membranes.
The existence of an early effect of testosterone, prior to the effects dependent upon interaction between the hormone-citosolic receptor complex and the cellular nucleus, has been explored in the present paper, in 3-day old chickens. Liver glycogen phosphorylase activity is increased before protein synthesis activation, and furthermore this effect is not blocked by antibiotics (actinomicin D and cycloheximide) inhibitor of protein synthesis. When liver phosphorylase is activated, cAMP levels are not enhanced, as would be expected, but deeply depleted. The hypothesis of a phosphorylase-kinase activation due to an increase in the intracellular Ca++ concentration is considered.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D002645:Chickens; D000242:Cyclic AMP / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D006005:Phosphorylases / Q000378:metabolism; D014176:Protein Biosynthesis; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D000242:Cyclic AMP; D006005:Phosphorylases