Central monoaminergic effects of two aporphine analogues to the putative serotonin-receptor agonist, 8-hydroxy-2-di-n-propylaminotetralin.
Two aporphine analogues to the potent and selective serotonin (5-HT) agonist, 8-hydroxy-2-di-n-propylaminotetralin (8-OH-DPAT) were studied with regard to their actions upon central monoaminergic systems. The biochemical and behavioural findings indicate that 8-hydroxy-N-methyl-aporphine (8-OH aporphine) and its N-n-propyl analogue (8-OH PNA) possess weak dopamine/noradrenaline antagonist- and agonist-like properties, respectively. In addition, both aporphines seemed to only weakly influence serotoninergic transmission. The latter findings are compared to those of known serotonin agonists (e.g. 8-OH-DPAT), and are discussed with particular reference to the structural requirements for activation of central 5-HT receptors.
D000818:Animals; D001060:Aporphines / Q000494:pharmacology*; D001679:Biogenic Amines / Q000502:physiology*; D001921:Brain / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology; D013329:Structure-Activity Relationship; D009435:Synaptic Transmission / Q000187:drug effects*
D001060:Aporphines; D001679:Biogenic Amines; D012701:Serotonin; C044197:8-hydroxy-N-n-propylnoraporphine; C044196:8-hydroxy-N-methylaporphine; D004298:Dopamine; D009638:Norepinephrine