Cyclic nucleotide levels of nasal secretions in allergic patients and control subjects.
Cyclic nucleotides (CND) levels of nasal secretions were studied in allergic rhinitis patients and control subjects. In methacholine-induced nasal secretion, allergic rhinitis patients had lower cAMP levels, higher cGMP levels and a lower cAMP/cGMP ratio than the control subjects. A close relationship was found between CND levels and the severity of daily symptoms in both methacholine-induced and antigen-induced nasal secretions.
D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D006801:Humans; D009297:Nasal Mucosa / Q000378:metabolism*; D009299:Nasal Provocation Tests; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*; D012636:Secretory Rate
D000242:Cyclic AMP; D006152:Cyclic GMP