Synthesis of C-analogues of kainic acids and their interaction with brain receptors.
The synthesis and the interaction with brain receptors of some 2-carboxy-5-isopropenylcyclopentaneacetic acids, C-analogues of kainic acids, are reported. They do not displace kainic acid at cortical or striatal receptors.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003342:Corpus Striatum / Q000378:metabolism; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000031:analogs & derivatives*; D008968:Molecular Conformation; D011759:Pyrrolidines; D051381:Rats; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D007608:Kainic Acid; D011759:Pyrrolidines; D018092:Kainic Acid Receptors; D017981:Receptors, Neurotransmitter