[Transnasal and transsphenoidal neuroadenolyses with alcohol. Indications. Technics. Results. Remarks about action mechanism (27 cases) (author's transl)].
The technique is of interest in deep bone pain in terminal metastasized cancer, but early relapses often occur. The hypoalgesia or analgesia obtained does not seem to result from endocrine mechanisms only, nor from the release of endogeneous opioid peptides. This neuroadenolysis seems to interfere in the pain pattern either through still unknown neurotransmitters, or through the dissociation of fibers transmitting pain to the floor of the diencephalon.
D004723:Endorphins / Q000502:physiology; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D007017:Hypophysectomy, Chemical / Q000379:methods*; D009369:Neoplasms / Q000150:complications; D018377:Neurotransmitter Agents / Q000502:physiology; D010146:Pain / Q000209:etiology; D059408:Pain Management
D004723:Endorphins; D018377:Neurotransmitter Agents
L'hypophysiolyse à l'alcool. Indications, techniques et résultats. Observations sur le mécanisme d'action (27 cas).