title: Effect of sodium diethyldithiocarbamate on placental passage and foetal distribution of cadmium and mercury in mice.
abstract: The administration of sodium diethyldithiocarbamate to 18 day pregnant mice, which previously had been given 109Cd2+ or 203Hg2+ was found to result in increased levels of the metals in the foetuses, in comparison with mice given the 109Cd2+ or 203Hg2+ alone. The level of 109Cd2+ in some foetal tissues was increased 30-60 times. In the animals given 203Hg2+ 3-5 times higher concentrations were seen in most foetal tissues of the sodium diethyldithiocarbamate-treated animals compared with animals not treated with this substance. Cadmium and mercury were shown to form highly lipophilic complexes with diethyldithiocarbamate and a facilitated transfer of these complexes through the placental membranes probably explains the increased uptake of the metals in the foetuses.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002104:Cadmium / Q000378:metabolism*; D004050:Ditiocarb / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D008628:Mercury / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D013859:Thiocarbamates / Q000494:pharmacology*; D014018:Tissue Distribution
chemical_list: D013859:Thiocarbamates; D002104:Cadmium; D004050:Ditiocarb; D008628:Mercury