Release of immunoreactive-dynorphin from the isolated guinea-pig small intestine is reduced during peristaltic activity.
The guinea-pig small intestine contains high amounts of immunoreactive dynorphin (9 pmol/g), which is released from the in vitro preparation under resting conditions (basal release). Initiation of peristaltic activity by distension of the intestinal wall via sustained elevated intraluminal pressure lowers the levels of immunoreactive dynorphin in the bathing solution (by more than 60%). The present data are suggestive of a role of this endogenous opioid peptide in the control of intestinal peristalsis.
D000818:Animals; D004399:Dynorphins; D004723:Endorphins / Q000378:metabolism*; D005769:Gastrointestinal Motility; D006168:Guinea Pigs; D007082:Ileum / Q000294:innervation*; D009433:Neural Inhibition; D010528:Peristalsis; D011863:Radioimmunoassay; D011957:Receptors, Opioid / Q000378:metabolism*
D004723:Endorphins; D011957:Receptors, Opioid; D004399:Dynorphins