title: Pharmacokinetic aspects of anxiolytic drug therapy.
abstract: Benzodiazepine derivatives are neuropharmacologically similar but may appear clinically distinct due to pharmacokinetic differences. The clinical effects of single doses depend mainly on rates of drug absorption and distribution, whereas drug accumulation is a major determinant of clinical action during multiple dosage. This paper outlines potential clinical implications of benzodiazepine pharmacokinetics.
mesh_terms: D000284:Administration, Oral; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000378:metabolism*; D001007:Anxiety / Q000188:drug therapy*; D001569:Benzodiazepines; D001711:Biotransformation; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines