title: Esters of 1,7,7-trimethyl-2-exo-piperidinobicyclo[2.2.1]heptan-3-endo-ol with antiarrhythmic, local anesthetic and other activities.
abstract: A series of aliphatic and aromatic esters of 1,7,7-trimethyl-2-exo-piperidinobicyclo[2.2.1]heptan-3-endo-ol is described. A number of these compounds showed antiarrhythmic activity in guinea pigs and mice, as well as surface anesthesia in rabbits and infiltration anesthesia in mice. Circulatory, cardiac and respiratory effects in dogs are also described.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000779:Anesthetics, Local / Q000138:chemical synthesis*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D001794:Blood Pressure / Q000187:drug effects; D001892:Camphanes / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006339:Heart Rate / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis; D051379:Mice; D011817:Rabbits; D012119:Respiration / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D001892:Camphanes; D006634:Histamine H1 Antagonists; C029583:1,7,7-trimethyl-2-exo-piperidinobicyclo(2.2.1)heptan-3-endo-ol; D000109:Acetylcholine