Angio-proliferative lesions in a homosexual boar with features resembling Kaposi's sarcoma.
Clinical, biopsy and necropsy studies of a homosexual boar revealed angio-proliferative lesions in the skin of the thigh, scrotum and the inguinal lymph node. Angiofibromas were identified in the dermis and subcutis of the thorax and mandible. The avidin-biotin-peroxidase complex technique demonstrated Factor VIII-related antigen as a marker for the neoplastic endothelial cells of the tumors. This boar also showed weight loss and lymphopenia. Explants of tumors were maintained in cultures for 22 passages and cultured cells produced tumors when injected subcutaneously into nude mice. No viral antigen was detected in the cultured tumor cells. Similarities and differences between the lesions in the boar and human Kaposi's sarcoma are discussed.
D000818:Animals; D002478:Cells, Cultured; D006394:Hemangiosarcoma / Q000473:pathology / Q000662:veterinary*; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology / Q000662:veterinary*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012514:Sarcoma, Kaposi / Q000473:pathology*; D012726:Sexual Behavior, Animal; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*; D014183:Transplantation, Heterologous