title: Superiority of partial ileal bypass over cholestyramine reducing cholesterol in familial hypercholesterolaemia.
abstract: Low density lipoprotein (LDL) turnover studies were conducted on three occasions in each of six patients with heterozygous familial hypercholesterolaemia (FH)-on diet, after 1 month on cholestyramine 16 g/day, and 2 months after partial ileal bypass. Partial ileal bypass lowered total and LDL cholesterol levels and increased the fractional catabolic rate of LDL to a greater extent than did cholestyramine; this difference presumably reflects the greater increase in bile acid excretion induced by the surgical procedure. Studies in two other heterozygotes showed that partial ileal bypass specifically enhanced receptor-mediated catabolism of LDL. The findings support the concept that therapeutic stimulation of bile acid synthesis increases the rate of receptor-mediated uptake and degradation of LDL by the liver.
mesh_terms: D000328:Adult; D001647:Bile Acids and Salts / Q000096:biosynthesis; D001835:Body Weight; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D005260:Female; D006579:Heterozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000178:diet therapy / Q000188:drug therapy / Q000628:therapy*; D007082:Ileum / Q000601:surgery*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011955:Receptors, Drug / Q000235:genetics
chemical_list: D001647:Bile Acids and Salts; D008077:Lipoproteins, LDL; D011955:Receptors, Drug; D002792:Cholestyramine Resin