Calcium-complexing versus vasorelaxant effect of acetate, lactate, and other bases.
The calcium-complexing abilities of acetate, bicarbonate, lactate, succinate, and citrate were quantified, and were found to differ substantially. Acetate was a more potent vasodilator than lactate, and the vasorelaxant potencies of acetate and lactate failed to correlate with their calcium-complexing ability. The vasodilator action of acetate was not abolished after correction for complexing of ionized calcium. Strips constricted with vasopressin were especially sensitive to the vasodilator effects of acetate.
D000085:Acetates / Q000494:pharmacology*; D019342:Acetic Acid; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002614:Chelating Agents; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D007473:Ion Channels / Q000187:drug effects*; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology; D017693:Sodium Bicarbonate; D013386:Succinates / Q000494:pharmacology; D019802:Succinic Acid; D014664:Vasodilation / Q000187:drug effects*
D000085:Acetates; D001639:Bicarbonates; D002614:Chelating Agents; D002951:Citrates; D007473:Ion Channels; D007773:Lactates; D013386:Succinates; D019343:Citric Acid; D019344:Lactic Acid; D017693:Sodium Bicarbonate; D012964:Sodium; D019802:Succinic Acid; D019342:Acetic Acid; D002118:Calcium