[Experimental investigations on the effect of etilefrinhydrochloride (Effortil) on heart and circulation of animals with partial ischaemic damage of the myocardium (author's transl)].
The effect of Etilefrin on the blood flow of normal and partial ischaemic myocardium with heat conductance probes as well as on the ventricular dynamics was investigated on 11 dogs under propiomazine-pentobarbital narcosis. Etilefrin was applied in doses of 0.04 mg/kg bw. and 0.2 mg/kg bw. At low doses, the blood flow was only elevated in normal myocardium, likewise the systolic aortic pressure, the diastolic aortic pressure decreased, the heart frequency was elevated, whereas the systolic pressure in the left ventricle was only slightly increased for a short time, the enddiastolic pressure unchanged, dp/dtmax rose significantly, but the heart minute volume only slightly. At higher doses, elevation of blood flow also appeared in partial ischaemic myocardium, the aortic pressure, systolic and diastolic, decreased considerably at first and then 20 min. p.i. rose to above the control value. The heart frequency was more elevated than at lower doses, the pressures in the left ventricle showed no obvious changes, dp/dtmax and heart minute volume were likewise considerably elevated. Radiological measurements of the ejection fraction and the mean circumferential fiber shortening velocity at higher Etilefrin doses showed also a positive inotropic effect. In consideration of this fact, therapy with Etilefrin appears useful in disturbances of cardiac function and at least shows no contraindication by means of myocardial blood flow.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D005039:Etilefrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D010656:Phenylephrine / Q000031:analogs & derivatives*; D013318:Stroke Volume / Q000187:drug effects
D010656:Phenylephrine; D005039:Etilefrine
Tierexperimentelle Untersuchungen zur Wirkung von Etilefrin-Hydrochlorid (Effortil) auf Herz und Kreislauf bei partiell ischämiegeschädigtem Myokard.