Cyclic AMP metabolism in peripheral blood lymphocytes from patients with Hodgkin's disease.
Intracellular levels of cyclic AMP and cAMP phospodiesterase activity of peripheral blood mononuclear cells of patients with Hodgkin's disease (HD) were studied. The cAMP levels were elevated by 137% in HD patients as compared to normal subjects. The levels were reduced during clinical remission but remained significantly higher than normal controls. These high levels of cAMP in HD patients may be due to reduced degradation of cAMP as the cAMP phosphodiesterase activity was reduced to 50% of normal. This observed altered metabolism still persisted even after depletion of adherent monocytes, indicating that the defect was in the lymphocytes.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000097:blood; D002448:Cell Adhesion; D002469:Cell Separation; D000242:Cyclic AMP / Q000097:blood*; D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D009000:Monocytes
D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases