title: [Observations on the immunological pathogenesis of the Schoenlein-Henoch disease. Diagnostic and therapeutic notes on 32 cases (author's transl)].
abstract: Diagnostic and therapeutic observations on 32 children affected by the Schoenlein Henoch disease are reported providing a contribution to the knowledge of the immunological pathogenetic mechanism of the disease. Platelets, fibrinogen, immunoglobulins, complement, immunocomplexes and fibrin degradation product in serum- and sometimes in urine- have been determined. Some data, as the increase of immunoglobulin A and fibrin degradation product, are typical of the involvement of an immunological mechanism. On the basis of these results, anticoagulant and anti-platelet aggregation drugs have been administered in combination with antiallergic and vascular protective drugs. In this manner, the coagulation mechanism, which is responsible for the enteric and renal intravascular alteration, is influenced.
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003348:Cortisone / Q000627:therapeutic use; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy / Q000276:immunology*; D007070:Immunoglobulin A / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D005338:Fibrin Fibrinogen Degradation Products; D006634:Histamine H1 Antagonists; D007070:Immunoglobulin A; D003348:Cortisone
vernacular_title: Osservazioni sulla patogenesi immunologica della malattia di Schoenlein-Henoc. Considerazioni diagnostico - terapeutiche su 32 casi.