Complete inhibition of food-stimulated gastric acid secretion by combined application of pirenzepine and ranitidine.
In a double-blind, placebo controlled and randomised secretory study the effectiveness of pirenzepine, ranitidine, and their combination was compared intraindividually in eight healthy subjects receiving intravenous bolus injections. Pirenzepine (0.15 mg/kg) plus ranitidine (0.6 mg/kg) suppressed peptone-stimulated gastric acid secretion from 69 +/- 11 to 2 +/- 0.4 mmol H+/3 h; the mean percentage inhibition was 97%. Postprandial gastrin was unaffected. There were only minor side-effects in a few experiments (reduction of salivation, brief blurring of vision), but no prolactin stimulation after ranitidine or ranitidine plus pirenzepine. The combined application of ranitidine and pirenzepine inhibited meal-stimulated acid secretion more effectively and produced fewer side-effects than the combination of cimetidine plus pirenzepine studied previously.
D000328:Adult; D001570:Benzodiazepinones / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005502:Food; D005663:Furans / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010461:Peptones; D010879:Piperazines / Q000494:pharmacology*; D010890:Pirenzepine; D011388:Prolactin / Q000097:blood; D011897:Random Allocation; D011899:Ranitidine
D001570:Benzodiazepinones; D004338:Drug Combinations; D005663:Furans; D005755:Gastrins; D006635:Histamine H2 Antagonists; D010461:Peptones; D010879:Piperazines; D010890:Pirenzepine; D011899:Ranitidine; D011388:Prolactin