title: Cold urticaria with persistent weals.
abstract: A patient with cold urticaria is described in whom weals appeared immediately after an ice cube test for 3 min and persisted for a week as a red, tender swelling. The duration of the oedema was dependent on the intensity of the immediate reaction. If the immediate wealing was blocked by treatment with an oral antihistamine 3 h before the ice cube test, no delayed reaction was seen. Antihistamines given after the immediate wealing had occurred did not influence the delayed reaction. Reactions to intradermally injected histamine, prostaglandin E, kallikrein, serotonin and serum appeared normal.
mesh_terms: D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology; D008875:Middle Aged; D013997:Time Factors; D014581:Urticaria / Q000188:drug therapy / Q000209:etiology*
chemical_list: D006634:Histamine H1 Antagonists