Autoradiographic distribution of nicotine receptors in rat brain.
The autoradiographic visualisation of 90%-specific tritiated nicotine binding to slide-mounted sections of rat brain is reported. Tritiated nicotine bound with high affinity (nanomolar Kd) and was selectively displaced by nicotinic agonists (e.g. L-nicotine approximately ACh greater than D-nicotine). The strikingly discrete distribution pattern obtained deviates from that of alpha-bungarotoxin, and suggests several possible roles for nicotinic transmission in the brain.
D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D002038:Bungarotoxins / Q000378:metabolism; D006801:Humans; D008297:Male; D009538:Nicotine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000378:metabolism* / Q000502:physiology; D009435:Synaptic Transmission
D002038:Bungarotoxins; D011978:Receptors, Nicotinic; D009538:Nicotine