Preliminary review of the interactions of ORG NC 45 with anaesthetics and antibiotics in animals.
In vitro (rat hemidiaphragm) and in vivo (rat and cat tibialis anterior muscle preparation) studies of the interactions between Org NC 45 and some i.v. anaesthetics and antibiotics were carried out. With the exception of ketamine 1 mg kg-1 none of the drugs tested in vivo significantly changed the time course of an Org NC 45 bolus injection. All of the drugs caused an enhancement of the neuromuscular block using infusions in vivo and also in the in vitro preparations. Org NC 45 seems to be potentiated in a manner similar to pancuronium.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002415:Cats; D003964:Diaphragm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004357:Drug Synergism; D066298:In Vitro Techniques; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D014673:Vecuronium Bromide
D000777:Anesthetics; D000900:Anti-Bacterial Agents; D014673:Vecuronium Bromide; D010197:Pancuronium