Nuclear and nucleolar effect of experimental endotoxemia on rabbit hepatocytes.
Nuclear and nucleolar ultrastructure was studied in hepatocytes of rabbits intravenously injected with a single dose of endotoxin to provide more information on the ultrastructural changes of hepatocytes produced by the endotoxemia. The observed changes were represented by a clumping of interchromatin granules, alteration of nucleolar architecture and formation of rodlet-like intranuclear inclusions. The alteration of the nucleolar architecture was characterized by loosely arranged rope-like nucleolonemata, partial retraction of the perinucleolar chromatin and increased numbers of fibrillar centers.
D000818:Animals; D002466:Cell Nucleolus / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure*; D002843:Chromatin / Q000648:ultrastructure; D004731:Endotoxins; D005260:Female; D002479:Inclusion Bodies / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure*; D008854:Microscopy, Electron; D011817:Rabbits
D002843:Chromatin; D004731:Endotoxins