title: [Proof of beta-2-adrenergic activity of etilefrin (effortil) via aimed recording of its tocolytic action (author's transl)].
abstract: In 21 normal deliveries the intrauterine pressure was measured continuously during the first stage of labor. Thus the tocolytic efficiency of Etilefrin was revealed. Intensity and duration of the tocolytic effect were related to the dose. Pressure and frequency of the contractions were diminished. Therefore these results are conclusive that Etilefrin, generally given for its alpha- and beta 1 mimetic effects, has an additional beta 2-mimetic and tocolytic component.
mesh_terms: D000318:Adrenergic beta-Agonists; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005039:Etilefrine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects; D010656:Phenylephrine / Q000031:analogs & derivatives*; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D000318:Adrenergic beta-Agonists; D010656:Phenylephrine; D005039:Etilefrine
vernacular_title: Nachweis der beta-2-adrenergen Wirkung von Etilefrin (Effortil) durch gezielte Registrierung seines tokolytischen Effektes.