Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified K99 or 987P pili: antibody production in response to vaccination.
Pilus-specific antibody levels measured by enzyme-linked immunosorbent assays in serum and colostrum of pregnant swine (dams) were shown to increase after parenteral vaccination with pili. Pilus-specific antibody levels in dams were correlated with protection of their suckling offspring against fatal diarrhea caused by enterotoxigenic Escherichia coli possessing the same pilus as the vaccine.
D000818:Animals; D000833:Animals, Suckling; D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D003126:Colostrum / Q000276:immunology; D003967:Diarrhea / Q000209:etiology / Q000517:prevention & control*; D004768:Enterotoxins / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology* / Q000378:metabolism; D005260:Female; D010861:Fimbriae, Bacterial / Q000276:immunology*; D007114:Immunization; D011247:Pregnancy; D013552:Swine
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004768:Enterotoxins