Hairy cell leukemia and human T cell leukemia virus.
HCL is a lymphoproliferative disorder, primarily of B cells. T cell variant HCL is a rare clinical entity, which has a clinical picture similar to that of the common B cell HCL disease. HTLV-II has been isolated from a case of T cell variant HCL. This subtype of HTLV-II-associated disease is indolent in character in comparison to the very aggressive HTLV-I-associated disease. Investigation of the biology and molecular genetics of HTLV is in progress. It is hoped that better understanding of HTLV and the comparative differences between HTLV-I and HTLV-II will provide specific insights into the mechanisms of human leukemogenesis.
D000328:Adult; D000368:Aged; D002460:Cell Line; D002872:Chromosome Deletion; D017977:Deltaretrovirus / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012192:Retroviridae Infections / Q000382:microbiology*; D013601:T-Lymphocytes / Q000276:immunology