Fatal disseminated BCG infection in an 18-year-old boy.
Death from disseminated infection with BCG (bacille Calmette-Guérin) after routine vaccination is rare, and various immune defects may be responsible. An 18-year-old boy died with widespread lymph-node, bone, lung, and liver involvement 6 years after BCG vaccination. Total numbers of B lymphocytes and T lymphocytes were normal, but T lymphocytes, while transforming normally in the presence of non-specific mitogens, did not transform in the presence of purified protein derivative. Delayed-type hypersensitivity skin tests were negative. Monocytes containing alpha-naphthylacetate esterase were absent.
D000293:Adolescent; D000995:Antitubercular Agents / Q000494:pharmacology; D001500:BCG Vaccine / Q000009:adverse effects*; D002648:Child; D004352:Drug Resistance, Microbial; D006801:Humans; D007111:Immunity, Cellular; D008264:Macrophages / Q000382:microbiology; D008297:Male; D009163:Mycobacterium bovis / Q000187:drug effects; D013997:Time Factors; D014376:Tuberculosis / Q000209:etiology* / Q000276:immunology
D000995:Antitubercular Agents; D001500:BCG Vaccine