title: CFS oligoclonal bands in MS and other neurological diseases detected by agarose isoelectric focusing and electrophoresis.
abstract: Agarose gel isoelectric focusing (IEF) and electrophoresis (EF) were compared for detection of CSF oligoclonal bands in multiple sclerosis (MS) and other neurological diseases. The CSF IgG/albumin ratio, the IgG-Index and the IgG synthesis per day in the CNS were also considered. IEF was highly sensitive, revealing oligoclonal bands in 100% of CSF from 40 clinically definite MS, while EF had a sensitivity of 70%. In 90 patients with other neurological diseases, IEF revealed oligoclonal bands in 25.5%, EF in 11.1%. The IgG-index was the most sensitive of the quantitative parameters.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002524:Cerebellar Ataxia / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid*; D007525:Isoelectric Focusing; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid*; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000276:immunology; D043025:Oligoclonal Bands; D010523:Peripheral Nervous System Diseases / Q000134:cerebrospinal fluid; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid
chemical_list: D007136:Immunoglobulins; D043025:Oligoclonal Bands