Role of thalamic motor nuclei in bilateral regulation of serotoninergic transmission in cat basal ganglia.
The effects of unilateral application of GABA (10(-5) M) into thalamic motor nuclei (ventralis medialis-ventralis lateralis, VM-VL) on 5-HT transmission in basal ganglia were investigated in halothane-anaesthetized cats implanted with several push-pull cannulae. The release of [3H]5-HT continuously synthesized from [3H]tryptophan was estimated in both caudate nuclei (CN), both substantia nigrae (SN) and in the dorsal raphe nucleus (DRN). [3H]5-HT release was decreased in the two CN and in the two SN but was enhanced in the DRN when GABA was applied into the VM-VL. These results indicate that thalamic motor nuclei are involved in a bilateral regulation of serotoninergic transmission in the basal ganglia.
D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D002415:Cats; D002421:Caudate Nucleus / Q000502:physiology; D005260:Female; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology; D009435:Synaptic Transmission; D013787:Thalamic Nuclei / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D012701:Serotonin; D005680:gamma-Aminobutyric Acid