Light and electron microscopic localization of enkephalin and tyrosine hydroxylase in neostriatum of fetal and adult rat brain.
In fetal rat brain, immunocytochemical localization of tyrosine hydroxylase and methionine (Met5)-enkephalin demonstrates that dopaminergic axons labeled with the biosynthetic enzyme can be detected in th neostriatum prior to the appearance of the peptide in neuronal perikarya. The tyrosine hydroxylase-labeled axon terminals in adult neotriatum may form axodendritio synapses with neurons containing enkephalin. However the majority of the dopaminergic axon terminals lack synaptic specializations in the mature neostriatum.
D000375:Aging; D000818:Animals; D003342:Corpus Striatum / Q000201:enzymology* / Q000254:growth & development / Q000648:ultrastructure; D004723:Endorphins / Q000032:analysis*; D004745:Enkephalins / Q000032:analysis*; D005260:Female; D005333:Fetus; D005455:Fluorescent Antibody Technique; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D011247:Pregnancy; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*
D004723:Endorphins; D004745:Enkephalins; D014446:Tyrosine 3-Monooxygenase