[Cimetidine and ranitidine in the treatment of reflux esophagitis].
The efficacy of the two H2-receptor-antagonists cimetidine (2 X 400 mg/die) and ranitidine (2 X 150 mg/die) for reflux oesophagitis was compared. 128 patients with endoscopically proven reflux oesophagitis in stages I and II based on the criteria of Savary and Miller took part in the trial on an out patients basis. Both drugs healed the oesophagus lesions in 70% of the patients after 6 weeks treatment. After 12 weeks, 90% of stage I patients and 80-85% of stage II patients were completely healed with both H2-antagonists. No significant difference was seen between the two drugs either with respect to the healing of the lesions or to the symptomatic improvement.
D000328:Adult; D000368:Aged; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D011899:Ranitidine / Q000627:therapeutic use*; D013997:Time Factors
D002927:Cimetidine; D011899:Ranitidine
Cimetidin und Ranitidin in der Behandlung der Refluxösophagitis.