Nerve growth factor and pancreatic APUD cells.
Pancreatic endocrine cells have been considered APUD cells and been thought to be of neural crest origin. Neonatal rats were passively immunized with nerve growth factor antiserum and the development of neural crest derived superior cervical ganglia was markedly inhibited. The pancreatic content of glucagon, insulin, and somatostatin was unaffected, suggesting that pancreatic A,B, and D cells are under different developmental control than are cells of known neural crest origin.
D001078:APUD Cells / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D005724:Ganglia / Q000254:growth & development*; D005934:Glucagon / Q000378:metabolism; D007106:Immune Sera / Q000494:pharmacology; D007116:Immunization, Passive; D007328:Insulin / Q000378:metabolism; D009414:Nerve Growth Factors; D009432:Neural Crest; D010179:Pancreas / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000378:metabolism
D007106:Immune Sera; D007328:Insulin; D009414:Nerve Growth Factors; D013004:Somatostatin; D005934:Glucagon