Influence of fiber on acidity, pepsin, and bile acids in human gastric juice in vitro.
The effect of a fiber-enriched wheat bran product, Fiberform, and a guar gum, Guarem, on gastric juice acidity, pepsin, and bile acid concentration was studied in vitro. Fiberform had a slight acid-binding capacity. The fiber preparation did not bind pepsin. Both products bound bile acids. With Fiberform the amount of bile acids bound was proportional to the amount of fiber and most pronounced at low pH and high bile acid concentration.
D001647:Bile Acids and Salts / Q000378:metabolism*; D004043:Dietary Fiber / Q000494:pharmacology*; D005685:Galactans / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008351:Mannans / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D053149:Plant Gums; D013997:Time Factors
D001647:Bile Acids and Salts; D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; C007894:guar gum; D010434:Pepsin A