Effects of hydrocortisone on the synthesis of Epstein-Barr virus antigens in P3HR-1 cells.
Hydrocortisone was capable of enhancing the synthesis of Epstein-Barr virus antigens in producer P3HR-1 cells which had been induced with a 24-hr pulse of 5-iodo-2-deoxy-uridine. The effect of hydrocortisone was time dependent, suggesting that an early step in the induction process, and not the antigen synthesis itself, was influenced by the drug.
D000956:Antigens, Viral / Q000032:analysis; D002051:Burkitt Lymphoma; D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007065:Idoxuridine / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects
D000956:Antigens, Viral; D007065:Idoxuridine; D006854:Hydrocortisone