Interrelated changes in gamma-glutamyltransferase activity and HDL-cholesterol level in the sera of patients with alcoholic liver injury.
The levels of HDL-cholesterol and gamma-glutamyltransferase in the sera of 17 patients with alcoholic liver injury were followed after abstinence and compared with those of 11 patients with acute non-alcoholic hepatitis. The activity of gamma-glutamyltransferase decreased in all cases irrespective of the type of liver injuries. The level of HDL-cholesterol also decreased in 11 of 17 cases with alcoholic liver injury. The other alcoholics, in whom HDL-cholesterol level increased or showed no definite change after withdrawal of alcohol, had severe and advanced liver injuries. In non-alcoholic hepatitis, the HDL-cholesterol level increased as normal liver functions were restored except for one case with cholestatic features. It was concluded that alcohol intake can increase HDL-cholesterol level even in the presence of a concomitantly induced hepatic lesion.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000097:blood*
D008075:Lipoproteins, HDL; D002784:Cholesterol; D005723:gamma-Glutamyltransferase