Effect of L-glutamic acid on [14C]GABA release from isolated rat retina.
The effect of various putative neurotransmitters on the release of [14C]GABA taken up by isolated rat retina was investigated by a perfusion technique. L-Glutamic acid initially enhanced the GABA release and subsequently reduced it to a level below the baseline rate. This enhancing effect of L-glutamic acid was Ca2+-dependent and tetrodotoxin-sensitive. L-Aspartic acid only reduced the GABA release, whereas kainic acid exhibited only a marked enhancement of its release. Acetylcholine, norepinephrine, dopamine, glycine and taurine did not have any significant effects on GABA release.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D007608:Kainic Acid