title: Transfer with dialysable transfer factor of T-lymphocyte cytolytic response to tick-bone encephalitis virus antigen in naive mice.
abstract: Transfer factor activity was demonstrated in the dialysable extract from lymphocytes from outbred donor mice, in which immunization with live attenuated Langat (E5 "14") virus induced a stage of high resistance against challenge with virulent tick-borne encephalitis virus. Administered to naive inbred recipient mice, the extract conveyed in them specific cytolytic activity, exerted by their T lymphocytes, as demonstrated by the 51Cr release assay on tick-borne encephalitis virus-infected syngeneic L-929 cells.
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D004669:Encephalitis Viruses, Tick-Borne / Q000254:growth & development / Q000276:immunology*; D005416:Flavivirus / Q000276:immunology*; D007114:Immunization; D007739:L Cells; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013601:T-Lymphocytes / Q000276:immunology*; D014165:Transfer Factor / Q000276:immunology*
chemical_list: D014165:Transfer Factor