Increases in alpha-adrenergic receptors in the hypothalamus of the genetically obese mouse (ob/ob).
Despite significantly elevated hypothalamic norepinephrine levels, genetically obese mice (ob/ob) had more hypothalamic alpha-adrenergic receptors than their lean littermates. This receptor increase appeared to be specific to the alpha-receptors in the hypothalamus since no change was found in the number of alpha-receptors in the cortex or in the dopamine and muscarinic receptors in the cortex and striatum.
D000317:Adrenergic alpha-Antagonists / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D004146:Dioxanes / Q000378:metabolism; D005260:Female; D007031:Hypothalamus / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D008820:Mice, Obese; D009928:Organ Specificity; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; C010654:(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane