Circulating somatostatin after food and glucose in man.
Using a recently validated radioimmunoassay, changes in circulating somatostatin have been measured in normal subjects after food (a standard breakfast), and oral and intravenous glucose. After the standard breakfast, a clear and sustained rise in plasma somatostatin was seen in all subjects from a mean value (+/-1 SE) of 28 +/- 7 pg/ml to a mean peak value, at 60 min of 57 +/- 11 pg/ml. When glucose was taken by mouth a significant but smaller rise was seen, but intravenous glucose caused no significant change in plasma somatostatin. A rise in circulating somatostatin after feeding has not previously been demonstrated in normal man and it is suggested that somatostatin may have an important endocrine role in the gut.
D000328:Adult; D001786:Blood Glucose; D005260:Female; D005502:Food; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D005934:Glucagon / Q000097:blood; D005947:Glucose; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D013004:Somatostatin / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D013004:Somatostatin; D005749:Gastric Inhibitory Polypeptide; D005934:Glucagon; D005947:Glucose