[Effect of chromium ions on the function of neuromuscular junctions].
It has been shown on neuro-muscular preparations of frog sartorius muscle that chromium ions in the concentrations 1-4 x 10(-6) g/ml strengthen spontaneous and evoked transmitter release. Cr3+ ions in the concentrations above 4 x 10(-6) g/ml decrease the membrane potential of muscle fibres, decrease the quantum content of the end plate potentials. Experiments on a single Ranvier node have shown that Cr3+ ions decrease the amplitude, increase the rate and duration of the action potential of a nerve fibre. It is concluded that chromium ions produce a pronounced effect on synaptic transmission, which differs significantly from the action of manganese, cobalt and nickel ions.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D002857:Chromium / Q000494:pharmacology*; D003035:Cobalt / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008345:Manganese / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009045:Motor Endplate / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000378:metabolism; D009532:Nickel / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*
D018377:Neurotransmitter Agents; D002857:Chromium; D003035:Cobalt; D008345:Manganese; D009532:Nickel
Vliianie ionov khroma na funktsiiu nervno-myshechnykh sinapsakh.