title: The role of natural coagulation inhibitors in hemostasis.
abstract: This article explores two of the components of the system involving the physiologic regulation of the coagulation cascade: anti-thrombin III and protein C. Pertinent molecular biology is reviewed, and the clinical conditions associated with changes in the proteins are discussed.
mesh_terms: D000990:Antithrombin III / Q000032:analysis / Q000502:physiology*; D020152:Antithrombin III Deficiency; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000628:therapy; D002097:C-Reactive Protein / Q000172:deficiency / Q000502:physiology*; D004347:Drug Interactions; D004727:Endothelium / Q000166:cytology; D006487:Hemostasis; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007124:Immunoenzyme Techniques; D007834:Lasers; D008958:Models, Molecular; D011863:Radioimmunoassay; D011956:Receptors, Cell Surface / Q000502:physiology; D018179:Receptors, Thrombin; D013917:Thrombin / Q000502:physiology; D013923:Thromboembolism / Q000209:etiology; D013927:Thrombosis / Q000517:prevention & control
chemical_list: D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin; D000990:Antithrombin III; D006493:Heparin; D002097:C-Reactive Protein; D013917:Thrombin