title: Sex steroid hormones influence the cAMP content in human endometrium during the menstrual cycle.
abstract: The measurement of the tissue concentrations of cyclic adenosine monophosphate (cAMP) in human endometrium shows that the levels of the nucleotide vary during the menstrual cycle, being 11.4 +/- (SE) 2.5 and 37.7 +/- (SE) 10.1 pmol/mg protein in the proliferative and secretory phase, respectively. The individual determinations of cAMP are significantly correlated to the estradiol/progesterone blood concentration ratio: by this means we obtained a superimposable distribution with the results of histologic examination suggesting that the hormones have a direct action in determining the cAMP levels in this tissue. The relevance of these observations for the physiology of the endometrium is discussed.
mesh_terms: D000242:Cyclic AMP / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005498:Follicular Phase; D006801:Humans; D008183:Luteal Phase; D008597:Menstrual Cycle; D011374:Progesterone / Q000097:blood*
chemical_list: D011374:Progesterone; D004958:Estradiol; D000242:Cyclic AMP