Oral anti-microbial prophylaxis in colonic surgery.
A combination of kanamycin and metronidazole administered for 3 days by mouth preoperatively, significantly suppresses both the aerobic and anaerobic colonic microflora, and significantly reduces the incidence of postoperative wound infection. During 6 years experience with this regimen, no toxic or untoward effects have been observed.
D000284:Administration, Oral; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003106:Colon / Q000382:microbiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents