Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide.
The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus--longitudinal muscle bioassay. The potency is accounted for by the first 13 residues.
D000595:Amino Acid Sequence; D000818:Animals; D004399:Dynorphins; D004723:Endorphins / Q000302:isolation & purification; D010446:Peptide Fragments / Q000032:analysis; D010902:Pituitary Gland / Q000032:analysis*; D013552:Swine; D014357:Trypsin
D004723:Endorphins; D010446:Peptide Fragments; D004399:Dynorphins; D014357:Trypsin