The effect of potassium on the hypertensive and electrolyte responses to ACTH administration in sheep.
This study examines the blood pressure and electrolyte response to adrenocorticotrophic hormone (ACTH) in K loaded sheep to test the hypothesis that ACTH-induced hypertension is blunted in K loaded sheep. ACTH treatment in sheep on a 'normal' Na (70-100 mmol/day) and high K intake (congruent to 800 mmol/day) increased mean arterial pressure (MAP) by upto 17 mmHg over 5 days. Cardiac rate and urinary Na excretion also increased. Plasma [Na] and [K] fell with ACTH. On a lower Na (30 mmol/day) and high K intake (congruent to 800 mmol/day) ACTH raised MAP by upto 16 mmHg over 5 days. Cardiac rate, urinary Na and K excretion also increased. Plasma [Na] fell and plasma [K] was unchanged. Thus, ACTH hypertension is not modified in chronically K loaded sheep, although electrolyte responses are different from normal.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004573:Electrolytes / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology*; D012756:Sheep; D012965:Sodium Chloride / Q000494:pharmacology
D004573:Electrolytes; D012965:Sodium Chloride; D011189:Potassium Chloride; D000324:Adrenocorticotropic Hormone