Food-stimulated gastric acid secretion inhibited by hormones and drugs. The role of vagal innervation.
Seven double-pouch dogs with one vagally innervated Amdrup pouch (AP) and one denervated Heidenhain pouch (HP) made possible comparison of gastric secretion from innervated and denervated mucosa at the same time in the same animal. Stimulation was done by food--a mixture of liver, heart, and bonemeal, 10g/kg. Cimetidine, 25, 50, 100, 200, and 400 mg; atropine, 0.031, 0.125, 0.5 and 1.0 mg; somatostatin, 0.5, 1.0, and 2.0 micrograms/kg/h; and secretin, 2 U/kg/h, were given 60 min after the meal, one single dose on each day. All compounds and all doses showed inhibition of gastric acid secretion in both pouches, significantly more pronounced in denervated mucosa for smaller doses of all compounds. In addition, the effect lasted longer in denervated mucosa. After somatostatin a pronounced rebound effect was seen. Cimetidine and atropine also showed significantly higher output than controls after the inhibition, but only in innervated mucosa.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004285:Dogs; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000294:innervation*; D012633:Secretin / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D012633:Secretin; D013004:Somatostatin; D001285:Atropine; D002927:Cimetidine