Sarcoidosis of the peripheral nerve: clinical, electrophysiological and histological study of two cases.
Two cases of sarcoid polyneuropathy were diagnosed by histological examination of the nerve biopsy. The electrophysiological findings in both patients suggested a neuropathy of axonal type, confirmed by a morphological study of a sural nerve biopsy by light microscopy and on teased-fiber preparations. The sarcoid granulomas were multiple, especially in case 2; they were sparse in the epineurial and perineurial spaces and absent in the endoneurium, whose interstitial component contained cellular infiltrations of scattered macrophages. Blood vessel changes were a constant morphological feature. The mechanisms that possibly contribute to the pathogenesis of the sarcoid neuropathy are discussed in relation to previous reports.
D000368:Aged; D001369:Axons / Q000502:physiology; D004576:Electromyography; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009132:Muscles / Q000294:innervation; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000473:pathology / Q000503:physiopathology*; D011115:Polyneuropathies / Q000503:physiopathology*; D012507:Sarcoidosis / Q000473:pathology / Q000503:physiopathology*; D012677:Sensation / Q000502:physiology; D013497:Sural Nerve / Q000473:pathology