[Efficacy of captopril in periarteritis nodosa with arterial hypertension and renal failure (author's transl)].
In a patient with periarteritis nodosa failure of antihypertensive treatment with beta-blockers and diuretics encouraged the authors to use captopril in doses of 150 mg per day. Blood pressure rapidly returned to normal levels. The hypotensive effect of captopril is ascribable to its action on the renin-angiotensin system, since plasma renin activity was particularly high in this patients.
D000803:Angiotensin I / Q000097:blood; D002216:Captopril / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000150:complications*; D011392:Proline / Q000031:analogs & derivatives*; D012083:Renin / Q000097:blood
D000803:Angiotensin I; D011392:Proline; D002216:Captopril; D012083:Renin
Périartérite noueuse compliquée d'hypertension artérielle et d'insuffisance rénale. Efficacité du captopril sur la pression artérielle.