title: [Dihydroergot plus in the long-term therapy of orthostatic hypotonic dysregulation in older patients].
abstract: 42 patients aged 75 /+- 12,5 years with orthostatic dysregulation and partly with hypotension were treated with the new combination of 20 mg etilefrine and 2 mg dihydroergotamine (Dihydergot plus) t.i.d. for 2 months in a single blind controlled study. The efficacy of Dihydergot plus was proved by a standardized orthostatic test and evaluation of subjective orthostatic symptoms. The resting blood pressure of the patients with hypotension increased from 106/63 mmHg to 114/67 mmHg. After changing from supine to standing position all patients showed a stabilized haemodynamic reaction. The fall of systolic and increase of diastolic blood pressure as well as the increase of heart rate were reduced and the subjective symptoms improved. There were also an improvement of the patients mood and activities of daily living. Dihydergot plus was well accepted by all patients during the treatment period.
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004087:Dihydroergotamine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005039:Etilefrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy*; D008297:Male
chemical_list: D004087:Dihydroergotamine; D005039:Etilefrine
vernacular_title: Dihydergot plus zur Langzeittherapie hypotoner orthostatischer Dysregulationen bei älteren Patienten.