[Study on tissue transfer of ceftriaxone in the field of obstetrics and gynecology].
Ceftriaxone (Ro 13-9904, CTRX) was studied about the tissue transfer in the gyneco-obstetric field and the following results were obtained. The transfer of CTRX into the uterine tissues and adnexa was favorable following an intravenous injection with 1 g. The mean serum level 1 hour after administration was 123.3 micrograms/ml while the tissue level ranged from 26 to 48 micrograms/g. The level in the pelvic dead space exudate reached a peak 3 to 6 hours after administration and got higher than the serum level at 5 to 6 hours.
D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D002443:Ceftriaxone; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D010388:Pelvis / Q000378:metabolism; D014018:Tissue Distribution; D002583:Uterine Cervical Neoplasms / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism
D002443:Ceftriaxone; D002439:Cefotaxime