[Contribution to the knowledge of immunological relations between Moniliformis moniliformis Bremser, 1811 (Acanthocephala) and Rattus norvegicus Berkenhout, 1769, var. albinos (author's transl)].
Cultured M. moniliformis (Acanthocephala) secrete and excrete antigenic substances. Immunoelectrophoretic analysis of these antigens revealed 14 lines of precipitation, 3 of which represent metabolic antigens. From the remaining 11 somatic antigens, 4 appear to be associated with the lemnisci. As shown by indirect immunofluorescence, specific antibodies predominantly bind to the lemnisci and to the worm's tegument. We therefore propose that metabolic antigens are either formed or stored in these tissues. Specific circulating antibodies have been demonstrated in rats infected with M. moniliformis using indirect immunofluorescence. Reinfection resulted in increased and prolonged antibody production (secondary response). Further immunofluorescence studies indicate that M. moniliformis is able to modify its antigenic set up, particularly between the 3rd and 5th weeks of infection. The immune reaction of the host against this parasite presumably leads to expulsion of worms starting 4 weeks after infection in females and 8 weeks after infection in males. Primary infection of rats with 30 worms elicits immunity. In fact, in preinfected rats only 26.6% of the transferred parasites could settle as compared to 66% following primary infection.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006373:Helminthiasis / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008990:Moniliformis / Q000276:immunology; D011817:Rabbits; D051381:Rats
D000941:Antigens; D007074:Immunoglobulin G
Contribution à la connaissance des relations immunologiques entre Moniliformis moniliformis Bremser, 1811 (acanthocephala) et Rattus norvegicus Berkenhout, 1769, var. albinos.