Angiogenic factor from synovial fluid resembling that from tumours.
Synovial fluids from 2 of 2 patients with osteoarthritis, 2 of 8 with rheumatoid arthritis, and 2 of 2 with ankylosing spondylitis contained a low-molecular-weight angiogenesis factor apparently identical with that derived from tumours. The amount of factor present was highest in patients with osteoarthritis, 2 patients with psoriatic arthropathy gave negative results. It is suggested that angiogenesis factor is involved, directly or indirectly, in the production of synovial exudate.
D000328:Adult; D000368:Aged; D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D002358:Cartilage, Articular / Q000098:blood supply; D005260:Female; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D007592:Joint Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009369:Neoplasms / Q000097:blood / Q000378:metabolism; D010003:Osteoarthritis / Q000378:metabolism; D013167:Spondylitis, Ankylosing / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism*
D043925:Angiogenesis Inducing Agents; D006133:Growth Substances