Involvement of class II HLA molecules in T cell activation by antigen. Implications for the autologous mixed lymphocyte reaction.
Our recent studies on the involvement of HLA Class II molecules in T cell activation by antigen are briefly reviewed. Both DR and MT Class II molecules were found to be able to function as restriction elements. The allotypic parts of DR molecules appeared to be most important in this respect, and were also found to influence the spectrum of antigen-specific responses. Both blood derived monocytes and Langherhans' dendritic cells were able to function as antigen-presenting cells, and expressed the same restriction elements. The relevance of these findings for the autologous mixed lymphocyte reaction (AMLR) is briefly discussed.
D000938:Antigen-Presenting Cells / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007801:Langerhans Cells / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D009000:Monocytes / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology
D000956:Antigens, Viral; D001324:Autoantigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D014373:Tuberculin