title: Sleep deprivation: effects on circadian rhythms of rat brain neurotransmitter receptors.
abstract: Specific binding of ligand to rat forebrain alpha- and beta-adrenergic, muscarinic cholinergic, opiate, benzodiazepine, and striatal dopamine receptors was measured at 4-hour intervals during the last 13 hours of a 24-hour sleep deprivation period, and during the first 11 hours of the recovery sleep period. In non-sleep-deprived controls a 24-hour rhythm in binding was evident. The minor differences between the sleep deprivation group and the control group consisted mainly in a reduced amplitude of the 24-hour rhythm under the sleep deprivation schedule. The results indicate that neither the 24-hour forced locomotion nor the subsequent prominent sleep rebound is accompanied by marked changes in the number of neurotransmitter receptors and their circadian rhythms.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004569:Electroencephalography; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012892:Sleep Deprivation; D012894:Sleep Stages
chemical_list: D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter