Rate constants for drug release from micellar solutions of non-ionic surfactants.
The release of weak acid from micellar solutions containing different concentrations of two structurally related non-ionic surfactants was estimated using a dynamic dialysis apparatus. In all cases the effect of the surfactant was to reduce the amount of weak acid transferred. The data have been subjected to compartmental analysis using non-linear regression analysis. Rate constants for exchange cross the dialysis membrane were independent of surfactant concentration. As surfactant concentration increased the rate constants for transfer from the non-micellar region did not show a marked change.
D007700:Kinetics; D008823:Micelles; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012044:Regression Analysis; D012459:Salicylates / Q000378:metabolism; D012995:Solubility; D013501:Surface-Active Agents / Q000494:pharmacology*
D008823:Micelles; D004364:Pharmaceutical Preparations; D012459:Salicylates; D013501:Surface-Active Agents