title: The structure of beta-lactamases.
abstract: The beta-lactamases are widely distributed in both Gram-positive and Gram-negative bacteria. They all inactivate penicillins and cephalosporins by opening the beta-lactam ring. Many varieties of the enzyme can be distinguished on the basis of their catalytic and molecular properties, but only amino acid sequence determination gives information upon which a molecular phylogeny can be based. The present evidence suggests that the beta-lactamases have a polyphyletic origin. All the beta-lactamases of currently known amino acid sequence belong to one homology group, here called class A enzymes. Class B consists of the mechanistically distinct Bacillus cereus beta-lactamase II, which preliminary partial sequence analysis suggests to be structurally unrelated to the class A enzymes. It is predicted that sequence analysis will show that further classes will need to be created to account for particular beta-lactamases of distinctive molecular and mechanistic properties.
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000201:enzymology; D005075:Biological Evolution; D055598:Chemical Phenomena; D002621:Chemistry; D011487:Protein Conformation; D001618:beta-Lactamases
chemical_list: D001618:beta-Lactamases