Genetic toxicity of erythrosine in yeast.
The genetic activity of erythrosine, a fluorescein dye used as a color additive, was studied in assays with growing cells of different strains of Saccharomyces cerevisiae. Erythrosine induced mitotic gene conversion and reverse mutation in strains D7 and XV185-14C of yeast. It failed, however, to increase mitotic recombination in strain D5. These results show that erythrosine possesses genotoxic activity for eukaryotic cells.
D004923:Erythrosine / Q000494:pharmacology*; D005452:Fluoresceins / Q000494:pharmacology*; D005800:Genes, Fungal / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects; D009153:Mutagens; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects / Q000235:genetics*; D013045:Species Specificity
D005452:Fluoresceins; D009153:Mutagens; D004923:Erythrosine