Receptors for the age of anxiety: pharmacology of the benzodiazepines.
Investigation of the actions of the benzodiazepines has provided insights into the neurochemical mechanisms underlying anxiety, seizures, muscle relaxation, and sedation. Behavioral, electrophysical, pharmacological, and biochemical evidence indicates that the benzodiazepines exert their therapeutic effects by interacting with a high-affinity binding site (receptor) in the brain. The benzodiazepine receptor interacts with a receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter, and enhances its inhibitory effects. The benzodiazepine receptor may also interact with endogenous substances and several naturally occurring compounds, including the purines and nicotinamide, are candidates for this role. Both the purines and nicotinamide possess some benzodiazepine-like properties in vivo, although further work will be required to confirm their possible roles as endogenous benzodiazepines.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants; D001007:Anxiety / Q000503:physiopathology; D001569:Benzodiazepines; D001921:Brain / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D008024:Ligands; D009126:Muscle Relaxation / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects; D011955:Receptors, Drug / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D013696:Temperature; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D007473:Ion Channels; D008024:Ligands; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid