title: Parkinson's disease: depletion of substantia nigra neurotensin receptors.
abstract: Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-dopamine interaction in human nigro-striatal circuits.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001345:Autoradiography; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D009496:Neurotensin / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism*; D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012016:Reference Values; D013378:Substantia Nigra / Q000378:metabolism*; D014316:Tritium
chemical_list: D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter; D014316:Tritium; D009496:Neurotensin