2,4-Dihydro-6-phenyl-1H-s-triazolo[4,3-a][1,4]benzoidiazepin-1-ones with antianxiety and antidepressant activity.
A series of 2,4-dihydro-6-phenyl-1H-s-triazolo[4,3-a][1,4]benzodiazepin-1-ones was prepared and evaluated for central nervous system activity. It was found that the 2-methyl-substituted analogues had interesting activity in tests useful for detecting anxiolytic agents, while N-2 substitution with omega-(dialkylamino)alkyl substituents give compounds with antidepressant potential as well as antianxiety activity.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis*; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001570:Benzodiazepinones