Intracarotidal injection of beta-adrenergic blocking agents: variations in the carotid sinus baro- and chemoreceptor activity.
The intracarotidal injection of some bet-adrenergic blocking agents (dl-acebutolol, dl-, l-, d-alprenolol, dl-bunitrolol, dl-buthoxamine, dl-, l-, d-INPEA, dl-Ko 592, dl-metoprolol, dl-oxprenolol, dl-propranolol, dl-tolamolol) in anesthetized and bivagotomized dogs reduced the arterial blood pressure and the baro- and chemoreceptor activity. These effects seem to be mediated by an interaction with central nervous, cardiovascular and respiratory structures dependent on the carotid arteries and by a direct interference of these drugs with the carotid sinus baro- and chemoreceptor structures. Moreover, these effects were not a result of the beta-adrenolytic properties of the drugs.
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002339:Carotid Arteries; D002346:Carotid Sinus / Q000187:drug effects*; D002628:Chemoreceptor Cells / Q000187:drug effects*; D003714:Denervation; D004285:Dogs; D005260:Female; D007269:Injections, Intra-Arterial; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects
D000319:Adrenergic beta-Antagonists