title: H-2-mediated resistance to an ecotropic type C retrovirus: localization of controlling genes and ontogenic studies of resistance.
abstract: H-2 recombinant mice of the C57BL/10 series were used to study resistance to infection by an ecotropic (B-tropic) type C retrovirus. The gene(s) responsible for resistance was mapped to I-E/I-C subregions. Ontogenic studies indicated that this I-region mediated resistance is not present in the neonate but develops with age, and is firmly established within 2 weeks after birth. This temporary neonatal susceptibility in mice of resistant genotype is not the result of active suppression of the immune response.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D006183:H-2 Antigens / Q000235:genetics*; D007125:Immunogenetics; D051379:Mice; D008810:Mice, Inbred C57BL; D012190:Retroviridae / Q000276:immunology*; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology
chemical_list: D006183:H-2 Antigens