Epstein-Barr virus and tumor promoters.
Epstein-Barr virus (EBV) can be maintained in lymphoblastoid cell lines. The infection is usually latent and the lack of a fully permissive cell have made the studies of the lytic functions of the virus difficult. In these cell lines virus production can be induced by addition of phorbol esters, n-butyrate, or nucleotide analogues. These compounds have been used to study EBV in several aspects: the latent and lytic functions of EBV. The possible use of this model system as an in vitro assay for tumor promoters. The mechanism behind the tumor promoter and n-butyrate induced activation of EBV.
D001402:B-Lymphocytes / Q000382:microbiology; D002273:Carcinogens / Q000032:analysis / Q000494:pharmacology*; D002460:Cell Line; D004279:DNA, Viral / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000254:growth & development; D008745:Methylation; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014775:Virus Activation / Q000187:drug effects
D002273:Carcinogens; D004279:DNA, Viral; D013755:Tetradecanoylphorbol Acetate