In vitro assessment of the fibrogenicity of mineral dusts.
Relying on in vitro production of the macrophage fibrogenic factor, an attempt was made to quantitate the fibrogenicity of mineral particles. Having determined the optimal conditions by means of quartz, two series of experiments were conducted with respirable coal mine dusts; the first employed artificial mixtures of a mine dust, having a low natural quartz content, with various proportions of quartz, and the second native dusts from European mines. The fibrogenic responses in both series suggest that dust concentration is more important than its composition. Quartz and ash contents of native dusts bore no evident relation to fibrogenicity, high quartz and ash levels sometimes being associated with low collagen levels and vice versa. Comparison with other information disclosed disparities with epidemiology and different experimental assessments. Factors affecting the disarray may well include the neglected lipid response in vivo and individual susceptibility, aspects which do not appear beyond experimental assay.
D000818:Animals; D003031:Coal; D004305:Dose-Response Relationship, Drug; D004391:Dust / Q000009:adverse effects*; D005347:Fibroblasts / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects*; D008906:Mining; D011791:Quartz / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012822:Silicon Dioxide / Q000009:adverse effects*
D003031:Coal; D004391:Dust; D011791:Quartz; D012822:Silicon Dioxide