Activity of human recombinant and lymphoblastoid interferons in human and heterologous cell lines.
Three human alpha interferon (HuIFN-alpha) preparations currently being used in clinical trials, rIFN-alpha A, rIFN-alpha 2, and lymphoblastoid IFN (LYM-IFN) had appreciable activity against encephalomyocarditis and vesicular stomatitis viruses (VSV) in guinea pig transformed and guinea pig embryo cells, but not mouse L or rabbit kidney cells. The level of activity in guinea pig cells, compared with human WISH cells, was 182% (range 9%-1,900%). These results suggest that the guinea pig may be useful for testing the antiviral, anticancer, or immunomodulatory activity of Hu alpha IFNs in vivo.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D004686:Encephalomyocarditis virus / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D051379:Mice; D011817:Rabbits; D013045:Species Specificity; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D007370:Interferon Type I