Autonomic function and control of pancreatic somatostatin.
In the canine pancreas alpha and beta adrenergic receptors exist on D cells with alpha stimulation inhibiting and beta stimulation increasing somatostatin release. There are no dopaminergic receptors on D cells. Stimulation of muscarinic receptors causes mild inhibition of somatostatin secretion. Autonomic receptors on the D cell may be physiologically stimulated in vivo via local ganglionic and/or central autonomic drivers.
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D007515:Islets of Langerhans / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D010179:Pancreas / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D013004:Somatostatin / Q000502:physiology*; D013997:Time Factors
D013004:Somatostatin; D011433:Propranolol; D007545:Isoproterenol; D004298:Dopamine; D004837:Epinephrine