Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type.
The activity of choline acetyltransferase (ChAT) and the concentration of somatostatin-like immunoreactive material (SLI) have been measured in 8 brain regions from 12 normal individuals and 12 cases of presenile and senile dementia of the Alzheimer type. ChAT activity was significantly lower in all 8 brain regions of demented patients and the SLI concentration was significantly reduced in 7 of the the 8. There were correlations between the extent of the reductions of ChAT activity and SLI concentration in four brain regions, and a greater reduction of parietal cortex SLI in younger patients than in the more elderly.
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003704:Dementia / Q000201:enzymology*; D006624:Hippocampus / Q000201:enzymology; D006801:Humans; D008875:Middle Aged; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin; D002795:Choline O-Acetyltransferase