title: Comparison of the systemic and pulmonary vascular response to endotoxin with plasma and lung lymph lysosomal enzyme release: effect of steroid pretreatment.
abstract: We wanted to compare the systemic and pulmonary vascular response to Escherichia coli endotoxin with changes in lysosomal enzyme activity in plasma and lung lymph in the unanesthetized sheep with a lung lymph fistula. We wanted to determine whether lysosomal enzyme activity (LE) was a reliable marker of injury and LE increase appears to be different for the two systems.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002199:Capillary Permeability; D002553:Cerebroside-Sulfatase / Q000378:metabolism*; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005966:Glucuronidase / Q000378:metabolism*; D007275:Injections, Intravenous; D008168:Lung / Q000098:blood supply*; D008196:Lymph / Q000201:enzymology; D008775:Methylprednisolone / Q000008:administration & dosage; D011292:Premedication; D012756:Sheep; D012772:Shock, Septic / Q000503:physiopathology*; D013429:Sulfatases / Q000378:metabolism*; D013897:Thoracic Duct
chemical_list: D004731:Endotoxins; D013429:Sulfatases; D002553:Cerebroside-Sulfatase; D005966:Glucuronidase; D008775:Methylprednisolone