Influence of suxamethonium on the potency of ORG NC 45 in anaesthetized patients.
The non-depolarizing neuromuscular block produced by Org NC 45 was potentiated by the previous administration of suxamethonium 1 mg kg-1, shown by twitch depression of 91.3 +/- 2.4% when the same dose of Org NC 45 was administered after recovery from suxamethonium compared with the control value of 71.9 +/- 6.5%. The recovery index was also prolonged from 8.1 +/- 0.3 to 10.4 +/- 1.0 min after suxamethonium. The dose-response curves for Org NC 45 showed a 1.66 potentiation factor for ED50 and 1.73 for ED95, caused by the previous administration of suxamethonium. This interaction is likely to occur in the plasma.
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D013390:Succinylcholine / Q000494:pharmacology*; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D013390:Succinylcholine; D010197:Pancuronium