title: Big form of gamma-melanotropin-like immunoreactivity in normal human plasma.
abstract: Using a radioimmunoassay for gamma 3-melanotropin (gamma 3-MSH), gamma-melanotropin-like immunoreactivity (gamma-MSH-LI) was detected in plasma extracts of normal subjects before and after metyrapone administration. Plasma gamma-MSH-LI from four normal men rose significantly after a single oral administration of metyrapone (30 mg/kg of body weight). Gel chromatographic study of plasma extract after metyrapone administration showed a single peak of gamma-MSH-LI near the elution position of mouse 16K fragment, however smaller forms of gamma-MSH-LI were not detected.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000818:Animals; D002850:Chromatography, Gel; D004723:Endorphins / Q000097:blood; D006801:Humans; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000097:blood*; D008797:Metyrapone; D051379:Mice; D008970:Molecular Weight; D011863:Radioimmunoassay / Q000379:methods; D012016:Reference Values; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008797:Metyrapone