[Effect of beta-adrenoreceptor stimulation on gastric secretion stimulated by histamine, acetylcholine, and pentagastrin].
In chronic experiments on dogs with gastric and duodenal fistulas and catheters implanted into the jugular vein, it was established that the beta-adrenoagonist novodrin inhibits gastric secretion stimulated with acetylcholine or pentagastrin but does not alter secretion stimulated with histamine. The inhibitory effect of novodrin on gastric secretion is a consequence of its direct action on beta-adrenoreceptors of the gastric mucosa. The scheme demonstrating interrelations of beta-adrenoreceptors to acetylcholine, gastrin and histamine is offered.
D000109:Acetylcholine / Q000008:administration & dosage; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000008:administration & dosage; D004285:Dogs; D004347:Drug Interactions; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects*; D006632:Histamine / Q000008:administration & dosage; D007545:Isoproterenol / Q000494:pharmacology*; D010418:Pentagastrin / Q000008:administration & dosage
D000318:Adrenergic beta-Agonists; D006632:Histamine; D002217:Carbachol; D010418:Pentagastrin; D007545:Isoproterenol; D000109:Acetylcholine
O vliianii vozbuzhdeniia beta-adrenoretseptorov na zheludochnuiu sekretsiiu, stimulirovannuiu gistaminom, atsetilkholinom i pentagastrinom.