title: The effect of intracerebroventricular infusions of CRF, sauvagine, ACTH (1-24) and ACTH (4-10) on blood pressure in sheep.
abstract: This study reviews the effects of intracerebroventricular (i.c.v.) infusion of corticotrophin releasing factor (CRF) and adrenocorticotrophic hormone (ACTH) (1-24) on blood pressure in conscious sheep. The effects of sauvagine, a peptide with 50% homology with CRF and ACTH (4-10) and other analogues of ACTH were studied. Intracerebroventricular infusion of CRF for 24 h at 10 and 100 micrograms/h increased blood pressure and heart rate. Sodium (Na) excretion also increased. Sauvagine at 10 micrograms/h also increased blood pressure. Both peptides raised body temperature and produced 'arousal' behaviour. ACTH (1-24) at 0.8 microgram/h for 48 h raised blood pressure and body temperature but had no significant effect on Na excretion or behavior. ACTH (4-10) and other related analogs (alpha-MSH, alpha gamma 1-MSH) at up to 10 micrograms/h for 48 h had no effects. These studies show that neuropeptides involved in the physiological response to 'stress' may have central effects on blood pressure.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D029845:Amphibian Proteins; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D002552:Cerebral Ventricles; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D003366:Cosyntropin / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D036361:Peptide Hormones; D010455:Peptides / Q000494:pharmacology*; D012756:Sheep; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D029845:Amphibian Proteins; D010446:Peptide Fragments; D036361:Peptide Hormones; D010455:Peptides; D014665:Vasodilator Agents; D003366:Cosyntropin; C025727:sauvagine; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; C011394:ACTH (4-10)