title: [Decrease in BSP clearance during epidural anesthesia at a constant flow rate. Clinical implications].
abstract: The fractional clearance K1 of bromsulphthalein was measured in twelve surgical patients at an interval of a least 48 hours. The first measurement was performed pre-operatively and the second postoperatively 24 hours after the operation, whilst the patients were receiving analgesia by the epidural injection of lignocaine at a constant flow rate. Between the two determinations there was a fall in BSP clearance of 25 +/- 11 p. 100 (range: -8 and -40 p. 100) P less than or equal to 0.0001. The clinical implications are discussed on the basis of concrete examples.
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis; D008875:Middle Aged; D013448:Sulfobromophthalein
chemical_list: D013448:Sulfobromophthalein
vernacular_title: Diminution des clairances de la B.S.P. sous analgésie péridurale a débit constant. Ses implications cliniques.