Prostaglandin F production by tissue explants from term pregnancies.
Explants of various tissues obtained from pregnant women at term and from nonpregnant women were maintained in culture and their capacities to synthesize prostaglandin (PGF) were evaluated. Myometrial and decidual tissues from pregnant women produced significantly smaller amounts of PGF than those from nonpregnant women, suggesting that PGF production is inhibited during gestation. Decidual PGF synthesis was also inhibited by the addition of progesterone, estradiol or indomethacin. The PGF synthesis of the chorion of women in labor was lower than that of women not in labor. In the later group, the cohrion, decidua and myometrium produced significant amounts of PGF, but amniotic PGF production was negligible. Our findings show that the decidua and chorion, as well as the myometrium, are potentially important sources of PGF production. PGF synthesis during pregnancy also may be affected by local inhibitory influences.
D046508:Culture Techniques; D003656:Decidua / Q000502:physiology; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D011247:Pregnancy; D011460:Prostaglandins F / Q000378:metabolism*; D014599:Uterus / Q000502:physiology*
D011460:Prostaglandins F