Toxicity of Momordica charantia lectin and inhibitor for human normal and leukaemic lymphocytes.
A haemagglutinin (lectin) and another protein (inhibitor) purified from the seeds of Momordica charantia inhibited protein and subsequently DNA synthesis in normal (mitogen-stimulated) and leukaemic human peripheral blood lymphocytes. The effect of the lectin was more rapid and more pronounced than that of the inhibitor, probably due to a better penetration of the lectin into cells. Both proteins acted on lymphocytes more markedly and at concentrations much lower than those required to inhibit protein synthesis in Yoshida ascites cells.
D004247:DNA / Q000096:biosynthesis; D006388:Hemagglutinins / Q000494:pharmacology; D006801:Humans; D037102:Lectins / Q000633:toxicity*; D007938:Leukemia / Q000097:blood; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D037121:Plant Lectins; D014176:Protein Biosynthesis; D012639:Seeds / Q000032:analysis
D006388:Hemagglutinins; D037102:Lectins; D037121:Plant Lectins; D004247:DNA