Chlorpromazine and frusemide in treatment of acute left-ventricular failure.
Chlorpromazine, a phenothiazine derivative with central and peripheral vasodilating effect, was given intravenously, with frusemide, to five patients with acute pulmonary oedema who did not respond to conventional treatment. Four of the five recovered fully. Chlopromazine seems to be a suitable vasodilator for use in treating acute pulmonary oedema outside intensive-care units, since its use does not require monitoring by invasive techniques.
D000208:Acute Disease; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002746:Chlorpromazine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000188:drug therapy* / Q000503:physiopathology; D012119:Respiration / Q000187:drug effects; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D002245:Carbon Dioxide; D005665:Furosemide; D002746:Chlorpromazine