Testicular DNA synthesis in vivo: changes in DNA synthetic activity following artificial cryptorchidism and its surgical reversal.
The kinetics of DNA synthesis of whole testis in mice was studied in artificial unilateral cryptorchidism and in its surgical reversal. Cryptorchidism impaired total testicular DNA synthesis. Approximately 1 month after the operation, activity of testicular DNA synthesis decreased to about 30% that of the contralateral intact testis. A complete recovery of DNA synthesis was observed within 1 month after the surgical reversal of cryptorchidism.
D000818:Animals; D003456:Cryptorchidism / Q000601:surgery*; D004247:DNA / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D013737:Testis / Q000032:analysis* / Q000033:anatomy & histology / Q000502:physiology; D014529:Uridine / Q000378:metabolism
D004247:DNA; D014529:Uridine