Anti-erythrocyte autoimmunisation during chronic falciparum malaria.
Anaemia during malaria is not completely understood. Fourteen cases of antierythrocyte autoimmunisation with anti-I specificity were investigated in a Paris hospital during a period of 2 years. The patients lived in Gabon and had not been taking antimalarial chemoprophylaxis. All had chronic malaria (strongly positive antimalarial immunofluorescent antibody tests). All the recognised caused for anti-erythrocyte autoimmunity were excluded. One possible explanation for these observations is some sort of interaction between I antigen and Plasmodium, the result of which facilitated penetration of the erythrocyte by the malarial parasite.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D002908:Chronic Disease; D004912:Erythrocytes / Q000276:immunology / Q000469:parasitology; D005260:Female; D005681:Gabon; D006801:Humans; D007114:Immunization; D008288:Malaria / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum
D001323:Autoantibodies