Beta-adrenergic stimulation and antidepressant activity.
The results presented here, together with the literature data, support the noradrenergic hypothesis of depressive states, and especially the involvement of beta-adrenergic receptors: --In animals, beta stimulants have the same spectrum of activity as other antidepressants. --These effects of both classical antidepressants and beta-adrenergic stimulants are antagonized by beta blockers. --Chronic administration of antidepressants results in a decrease of beta receptors. --Salbutamol, a beta-adrenergic stimulant had, in depressed patients, a clear and rapid antidepressant effect.
D000318:Adrenergic beta-Agonists; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002997:Clomipramine / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology; D003866:Depressive Disorder / Q000503:physiopathology; D006801:Humans; D008297:Male; D051379:Mice; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D000928:Antidepressive Agents; D002997:Clomipramine; D000420:Albuterol