title: Haloperidol and clonidine increase, and apomorphine decreases ultrasonic vocalizations by gerbils.
abstract: Ten psychotropic drugs that have putative effects on central brain neurotransmitters were assessed for influences on ultrasonic signaling relative to general activity in male Mongolian gerbils. Haloperidol (1 mg/kg IP), a dopamine antagonist, and clonidine (0.1 mg/kg IP), a norepinephrine agonist, increased ultrasonic signaling, and apomorphine (5 mg/kg IP), a dopamine agonist, decreased ultrasonic signaling. Catecholamines may modulate ultrasonic signaling in the gerbil. Body temperature changes were positively with ultrasonic emission in tests after saline, haloperidol, apomorphine, and 5-hydroxytryptophan (30 mg/kg IP).
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D005849:Gerbillinae / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology; D014465:Ultrasonics; D014828:Vocalization, Animal / Q000187:drug effects*
chemical_list: D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs; D006916:5-Hydroxytryptophan; D006220:Haloperidol; D003000:Clonidine; D001058:Apomorphine