Avoidance facilitation by chlordiazepoxide-amphetamine combinations in mice: effect of alpha-methyl-p-tyrosine.
Chlordiazepoxide (CDP) and amphetamine (AMPH) were tested, alone or in combination, in BALB/c mice pretreated with alpha-methyl-p-tyrosine (AMT) and subjected to shuttle-box avoidance training. CDP and AMPH, given alone, partly reversed avoidance depression induced by 50 mg/kg of AMT, but were ineffective in mice pretreated with 100 mg/kg of AMT. Stronger effects were produced by CDP-AMPH combinations, which also improved avoidance performance in mice pretreated with the higher dose of AMT. The results suggest that catecholamines may play a role in the facilitation of avoidance induced by CDP, especially when given in combination with AMPH.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D002707:Chlordiazepoxide; D000661:Amphetamine; D014446:Tyrosine 3-Monooxygenase