A possible role for calcium in cyclic nucleotide mediated fluid secretion.
This article suggests that calcium acts as an intermediate for intestinal fluid secretion mediated by adenosine-3':5'-cyclic monophosphoric acid (cAMP) and guanosine -3':5-'cyclic monophosphoric acid (cGMP). It is hypothesized that microbial enterotoxins disrupt the normal interrelationships between calcium and cyclic nucleotides, thereby leading to adverse biological effects. It is further proposed that the inhibitory effect of chlorpromazine on calmodulin accounts for the ability of this drug to inhibit enterotoxins which separately elevate cAMP or cGMP concentrations.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002772:Cholera Toxin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D006152:Cyclic GMP / Q000502:physiology*; D006162:Guanylate Cyclase / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological
D002772:Cholera Toxin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP; D002118:Calcium