[Demethylation of N-methylphenylalkylamines and propylhexedrin as well as of their N-formyl- and formyl)N-methoxymethyl analogues by rat liver homogenates (author's transl)].
The N-demethylation of various secondary N-methylphenylalkylamines and propylhexedrin in the 9.000-g-supernatant of rat liver homogenates is inhibited by introduction of a N-formyl group. Higher reaction rates for the O-methyl derivatives of pholedrin are attributable to an additional O-demethylation which is obviously favoured, when the N-demethylation is inhibited by the formyl group. The velocity of the oxidative degradation of the methoxymethyl group in formyl(N-methoxymethyl) analogues is markedly higher than the N-demethylation rates of the formyl)N-methyl) derivatives and depends to a greater extent upon the structure of the side-chain and the degree of hydrogenation of the nucleus.
D000588:Amines / Q000378:metabolism*; D000818:Animals; D003640:Dealkylation; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D011437:Propylamines / Q000031:analogs & derivatives / Q000378:metabolism*; D051381:Rats
D000588:Amines; D011437:Propylamines
Demethylierung von N-Methylphenylalkylaminen und Porpylhexedrin sowie deren N-Formyl- und Formyl(N-methoxylmethyl)-Analoga durch Rattenleberhomogenate.