[Effect of carbidine on dopamine turnover in the rat corpus striatum].
It has been shown that carbidine increases the level of homovanillic acid (HVA) in the corpus striatum of the rat brain. The changes in HVA level allowed forming a judgement on dopamine turnover. By the intensity of this effect, carbidine proved inferior to typical neuroleptics--triphtazine and ftorfenazin. The antidepressant ftoracizin did not alter HVA level. Carbidine ranks between neuroleptics and antidepressants in terms of the effect on dopamine turnover.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005476:Fluphenazine / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D010640:Phenothiazines / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D014268:Trifluoperazine / Q000494:pharmacology
D014150:Antipsychotic Agents; D002243:Carbolines; D007211:Indoles; D010640:Phenothiazines; D014268:Trifluoperazine; C001228:fluoracizine; D005476:Fluphenazine; D004298:Dopamine; D006719:Homovanillic Acid
Vliianie karbidina na krugooborot dofamina v polosatom tele mozga krys.