[Comparative study of the in vitro activity of dibekacin, piperacillin, cefotaxime and cefuroxime on gram-negative bacteria].
The activity in vitro of the dibekacin was compared with that of piperacillin, cefotaxime and cefuroxime against 266 recently isolated gramnegative pathogens. Dibekacin was consistently more potent than cefotaxime, cefuroxime and piperacillin, with MIC50 and MIC90 values lower than the others. Dibekacin and cefotaxime were essentially similar in activity against all the bacteria, with the singular exception of Pseudomonas aeruginosa, which was markedly more susceptible to the former drug.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002439:Cefotaxime / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D003982:Dibekacin / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D009016:Moraxella / Q000187:drug effects; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003982:Dibekacin; D002439:Cefotaxime; D002444:Cefuroxime; D010878:Piperacillin
Studio comparativo dell'attivita' in vitro di dibekacina, piperacillina, cefotaxime e cefuroxime su batteri Gramnegativi.