title: [Preparation and beta adrenolytic activity of some derivatives of naphthol-[2,1-b]furan].
abstract: Some 1-(naphtho[2,1-b]furan-2-yl)-2-(t-butylamino)ethanols were synthesized for possible beta-adrenergic receptor blockade. The compounds may be considered to be derived from naphthyloxypropanolamines, the side chain of which is partially included in a furan ring. The pharmacological profile of 1-(naphtho[2,1-b]furan-2-yl)-2-(t-butylamine)ethanol (I b) is quite similar to that of propranolol without cardiac depressant properties.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D005663:Furans / Q000138:chemical synthesis / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D005663:Furans
vernacular_title: Preparazione ed attività beta-adrenolitica di alcuni derivati del nafto[2,1-b]furano.