The potential of GABA-mimetics in the therapy of extrapyramidal disorders.
GABA mimetics inhibit extrapyramidal DA and ACh neurons and affect an unknown system beyond both DA and ACh receptors, which is involved in extrapyramidal motor outputs. Based on these data, the rationale is discussed for the clinical use of GABA mimetics in Huntington's chorea, parkinsonian tremor, L-DOPA or neuroleptic-induced dyskinesias.
D014150:Antipsychotic Agents / Q000009:adverse effects; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000188:drug therapy*; D004298:Dopamine / Q000502:physiology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D009474:Neurons / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000502:physiology; D011955:Receptors, Drug / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D014150:Antipsychotic Agents; D011955:Receptors, Drug; D007980:Levodopa; D005680:gamma-Aminobutyric Acid; D004298:Dopamine