Dantrolene and the effect of temperature on the spontaneous release of transmitter at the frog neuromuscular junction.
The characteristic effect of temperature on m.e.p.p. frequency at the amphibian neuromuscular junction is unaltered by the presence of Dantrolene (an agent that is believed to reduce the efflux of Ca2+ from intracellular stores) or by changes in [Ca2+)o. It is concluded that temperature affects the release system directly, with a transition temperature at about 16 degrees C.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003620:Dantrolene / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D011894:Rana pipiens; D013696:Temperature
D018377:Neurotransmitter Agents; D003620:Dantrolene; D002118:Calcium