[Effects of adrenal medullectomy and passive immunization with an anti-CRF antiserum on the corticotropin secretion in response to stress in Long-Evans rats].
Ether stress-induced ACTH and corticosterone secretion is similar in 60 days adrenal medullectomized and intact Long-Evans Rats. Passive immunisation with a 41-CRF antiserum impairs corticotropic function after stress. This decrease is more pronounced in adrenal medullectomized than in intact animals. These results suggest that epinephrine plays a minor role on the stress induced ACTH secretion. This role can be demonstrated only after immunoneutralisation of endogenous 41-CRF.
D000313:Adrenal Medulla / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000276:immunology / Q000502:physiology*; D004837:Epinephrine / Q000502:physiology; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*
D007106:Immune Sera; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone; D004837:Epinephrine
Effets de la médullosurrénalectomie et de l'immunisation passive par un sérum anti-CRF sur la secrétion corticotrope en réponse au stress chez le rat Long-Evans.