Studies on osteoporosis X. Effect of estrogen-progestin combination on heparin-induced osteoporosis.
Neutron activation analysis was employed to determine total body calcium in C3H/St(Ha) female mice. As 99% of body calcium is in bone, loss of calcium was used as an index of bone loss (osteoporosis). Heparin (500 U/kg b.i.d. caused bone loss in 3 months. Premarin (2 mg/kg q.d.) or norethindrone (40 mg/kg q.d.) alone prevented this osteoporosis. A Premarin-norethindrone combination (2 mg - 10 mg q.d. respectively) appeared to be somewhat more effective than either agent alone, but this difference was not significant at the 5% level. Combinations of estrogen and progestins may prevent metabolic bone disease at the same time reducing the danger of estrogen induced neoplasia.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004359:Drug Therapy, Combination; D004967:Estrogens / Q000008:administration & dosage*; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage; D005260:Female; D006493:Heparin; D051379:Mice; D008809:Mice, Inbred C3H; D009640:Norethindrone / Q000008:administration & dosage; D010024:Osteoporosis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D011372:Progestins / Q000008:administration & dosage*
D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D011372:Progestins; D006493:Heparin; D002118:Calcium; D009640:Norethindrone