[Neuroendocrine correlations in the pathogenesis and pathology of Parkinson disease].
In Parkinson's disease the decrease of dopamine in the nigro-striatal pathway is allied to modifications of other neuromodulation systems. The biochemical disorder of cholinergic, gabaergic and epinephrinergic pathways is present. Moreover the alteration of certain neuropeptides such as endorphins or enkefalins have been found. The Authors analyse the functional repercussions of these important biochemical modifications in the T.I.D.A. tract. In particular the variation of PRL synthesis and secretion due to dopamine deficiency during basal conditions and after pharmacological treatment is discussed.
D001545:Benserazide / Q000494:pharmacology / Q000627:therapeutic use; D004298:Dopamine / Q000172:deficiency* / Q000502:physiology; D004723:Endorphins / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects; D013972:Thyrotropin / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology
D004723:Endorphins; D009419:Nerve Tissue Proteins; D011954:Receptors, Dopamine; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D001545:Benserazide; D011388:Prolactin; D013972:Thyrotropin; D004298:Dopamine
Correlati neuroendocrini nella patogenesi e nella patologia del morbo di Parkinson.