Characteristics of three new avian sarcoma viruses, ASV 9, ASV 17, and ASV 25.
Three new avian sarcoma viruses, ASV 9, ASV 17, and ASV 25, were isolated from spontaneous tumors. They transform chicken embryo fibroblasts but not hemopoietic cells and induce fibrosarcomas in young chicks. All three viruses belong to the envelope subgroup A and cannot replicate without a helper virus, because they lack the pol and most, if not all, of the env gene. ASV 9 and ASV 17 have a genome of 5.0 kb; the genome of ASV 25 is 6.0 kb. The following onc sequences were tested for homology to the genomes of the three new avian sarcoma viruses: src, fps, yes, myc, myb, erbA, and erbB. These tests were negative except for erbB which showed faint hybridization with the genome of ASV 25. ASV 9 codes for a prominent 130-kdalton gag-linked transformation-specific protein. ASV 17 and ASV 25 transformed cells appear to contain multiple gag-linked transformation-specific proteins that still require further study.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000032:analysis / Q000235:genetics* / Q000472:pathogenicity; D002642:Chick Embryo; D015683:Gene Products, gag; D005814:Genes, Viral; D010455:Peptides / Q000032:analysis; D012191:Retroviridae Proteins / Q000032:analysis; D015291:Transforming Growth Factors; D014759:Viral Envelope Proteins / Q000032:analysis; D014760:Viral Fusion Proteins; D014779:Virus Replication
D015683:Gene Products, gag; D010455:Peptides; D012191:Retroviridae Proteins; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins; D015291:Transforming Growth Factors