Pharmacokinetics of fentanyl in children with renal disease.
Two cases of fentanyl anesthesia in children with renal diseases are described. In a case of end stage renal failure, the pharmacokinetic parameters during cardiac surgery were similar to 18 children from the same age group with normal renal function. In a case of Wilm's tumor, there was an unusually prolonged elimination half-life of fentanyl and smaller distribution volume as compared to pediatric parameters during fentanyl anesthesia.
D000771:Anesthesia, Intravenous; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D005260:Female; D005283:Fentanyl / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000601:surgery; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000601:surgery; D007700:Kinetics; D013997:Time Factors; D009396:Wilms Tumor / Q000378:metabolism* / Q000601:surgery
D005283:Fentanyl