[Acute promyelocytic leukemia. Review of the literature].
Acute promyelocytic leukemia is characterized by bone marrow infiltration with hypergranular promyelocytes, often with Auer bodies. Clinically it is characterized by a hemorrhagic syndrome caused by a disseminated intravascular coagulation. Karyotypic studies have shown a frequent translocation t(15;17). Improved prognosis resulted from chemotherapy with DAT and treatment with heparin.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology; D000903:Antibiotics, Antineoplastic; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D002479:Inclusion Bodies; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009279:Naphthacenes / Q000627:therapeutic use; D014411:Neoplastic Stem Cells / Q000648:ultrastructure; D013866:Thioguanine / Q000627:therapeutic use; D014178:Translocation, Genetic
D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D003561:Cytarabine; D006493:Heparin; D013866:Thioguanine; D003630:Daunorubicin
La leucosi acuta promielocitica. Revisione della letteratura.