Induction of a distinct nuclear poly(A) polymerase and the production of anti-tumor poly(A) polymerase antibodies in hepatocarcinogenesis.
Primary hepatomas induced in rats by an azo dye contained a distinct nuclear poly(A) polymerase which was different from the corresponding normal liver enzyme with respect to molecular weight and peptide map. The two enzymes could also be distinguished by their immunological characteristics. Sera from the carcinogen-fed rats contained antibodies to the tumor poly(A) polymerase even before the appearance of neoplastic nodules.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D002467:Cell Nucleus / Q000201:enzymology*; D004790:Enzyme Induction; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology* / Q000276:immunology; D008297:Male; D009713:Nucleotidyltransferases / Q000096:biosynthesis*; D011062:Polynucleotide Adenylyltransferase / Q000096:biosynthesis* / Q000276:immunology; D051381:Rats; D011916:Rats, Inbred F344
D000906:Antibodies; D009713:Nucleotidyltransferases; D011062:Polynucleotide Adenylyltransferase