title: Inhibition of neutral proteases from polymorphonuclear (PMN) neutrophils by salicylazosulfapyridine (SASP).
abstract: Cytochemical methods were used to demonstrate the inhibitory effect of salicylazosulfapyridine (SASP) on the activity of neutral proteases produced by neutrophilic granulocytes (PMN proteases). The SASP metabolites (5-aminosalicylic acid and sulfapyridine), produced by splitting of SASP by bacteria in the colon, did not inhibit the activity of PMN proteases. Paradoxically, sulfapyridine intensified PMN protease activity. A similar effect however could not be demonstrated for 5-aminosalicylic acid.
mesh_terms: D000328:Adult; D000636:Aminosalicylic Acids / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D011480:Protease Inhibitors; D013427:Sulfapyridine / Q000494:pharmacology; D012460:Sulfasalazine / Q000494:pharmacology*
chemical_list: D000636:Aminosalicylic Acids; D011480:Protease Inhibitors; D012460:Sulfasalazine; D013427:Sulfapyridine