title: [Isolation and identification of some metabolites of bromazine from human urine (author's transl)].
abstract: In addition to the unchanged drug nine metabolites have been found in human urine after the administration of bromazine (2-(p-bromophenyl-phenylmethoxy)-1-N,N-dimethyl-ethylamine). Three compounds were extractable under alkaline conditions; they were identified as bromazine-N-oxide (II), N-monodesmethylbromazine (III) and N-didesmethylbromazine (IV). Two other substances were extractable under alkaline and acidic conditions, p-bromobenzhydrol (VI) and p-bromobenzophenone (VIII). Another metabolite--extractable at pH 7--was p-hydroxybenzophenone (IX). Treatment of precipitated conjugated compounds with beta-glucuronidase or hydrochloric acid resulted in the liberation of IV, VI and IX, all of which were also found as unconjugated compounds.
mesh_terms: D001711:Biotransformation; D004155:Diphenhydramine / Q000031:analogs & derivatives* / Q000652:urine; D006634:Histamine H1 Antagonists / Q000652:urine*; D006801:Humans; D006868:Hydrolysis
chemical_list: D006634:Histamine H1 Antagonists; D004155:Diphenhydramine; C011410:bromodiphenhydramine
vernacular_title: Isolierung einiger Metaboliten von Bromazin aus menschlichem Harn and ihre Identifizierung.