Metomidate, etomidate and fentanyl as injectable anaesthetic agents in mice.
Light surgical anaesthesia lasting 12-15 min was produced by metomidate at 50 mg/kg and by etomidate at 30 mg/kg after intraperitoneal injection. Full surgical anaesthesia lasting about 160 min was achieved after subcutaneous injection of a metomidate-fentanyl mixture (60 mg/kg: 0.06 mg/kg) and this proved superior to etomidate-fentanyl given subcutaneously or intraperitoneally. It was concluded that metomidate-fentanyl is superior to pentobarbitone and tribromoethanol as an injectable anaesthetic for mice.
D000768:Anesthesia, General / Q000379:methods / Q000662:veterinary*; D000818:Animals; D000431:Ethanol; D005045:Etomidate; D005283:Fentanyl; D007093:Imidazoles; D007274:Injections, Intraperitoneal / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D051379:Mice; D010424:Pentobarbital
D007093:Imidazoles; D000431:Ethanol; D010424:Pentobarbital; D005283:Fentanyl; D005045:Etomidate