The effect of neuroleptics, tranquillizers, narcotics, antidepressants and anticonvulsive drugs on the alterations of mouse behaviour caused by acetaldehyde.
In a study of the effect of 26 psychoactive drugs on the complex of mouse behaviour changes caused by acetaldehyde it was found that tranquillizers, hypnotics, sodium oxybutyrate and ethanol are the most efficient. The differences in teh drug effects were determined by a tan alpha criterion. Antidepressants and neuroleptics have equal tan alpha, whereas narcotics, anti-convulsive drugs and tranquillizers all have similar tan alpha, but greater than that of the antidepressants and neuroleptics. A direct dose/effect relationship was found to exist for all the drugs investigated except for neuroleptics and antidepressants. For the latter drugs an increase in dose is followed by an increased effect, which, however, decreases on further increase of the dose. The convulsive syndrome is completely abolished only by tranquillizers and narcotics. Our results are quite in agreement with clinical data about the effectiveness of psychoactive drugs in the treatment of the alcohol abstinence syndrome. The method can be used not only for screening purposes, but also to define the specificity in the action of antialcoholic drugs.
D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D003292:Convulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D051379:Mice; D009294:Narcotics / Q000494:pharmacology*; D012978:Sodium Oxybate / Q000494:pharmacology; D014149:Tranquilizing Agents / Q000494:pharmacology*
D000927:Anticonvulsants; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D003292:Convulsants; D006993:Hypnotics and Sedatives; D009294:Narcotics; D014149:Tranquilizing Agents; D000431:Ethanol; D012978:Sodium Oxybate; D000079:Acetaldehyde