[Kidney tolerance of fosfomycin in humans with normal kidney function (author's transl)].
In a study with informed healthy volunteers Fosfomycin and their renal tolerance was under investigation. 6 volunteers received 15 g Fosfomycin on three consecutive days. The activity of the brush border enzyme alanine-aminopeptidase (AAP) in 24-hour urine has been measured. It could be demonstrated that these high dosages of Fosfomycin have been without any influence on the membrane integrity. Functional parameters as creatinine-clearance remained unchanged as well.
D000328:Adult; D000626:Aminopeptidases / Q000652:urine; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018826:CD13 Antigens; D003404:Creatinine / Q000652:urine; D004361:Drug Tolerance; D005578:Fosfomycin / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008871:Microvilli / Q000201:enzymology
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D003404:Creatinine; D000626:Aminopeptidases; D018826:CD13 Antigens
Untersuchungen zur Nierenverträglichkeit von Fosfomycin bei normaler Nierenfunktion.