title: Intravenous bicuculline test in mice: characterization with GABAergic drugs.
abstract: The effects of GABAergic drugs having diverse modes of action were studied in the myoclonic seizure syndrome induced by intravenous bicuculline in mice. The elicited syndrome can be antagonized dose-dependently by GABA-agonists, by GABA-transaminase inhibitors, by GABA neuronal uptake inhibitors, and by benzodiazepines stereospecifically after appropriate premedication times and routes. This test is proposed as a useful in vivo test for examination of compounds presumed to modify GABAergic function. It is pharmacologically relevant and warrants inclusion in any program involving GABAergic drugs.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001569:Benzodiazepines; D001640:Bicuculline / Q000008:administration & dosage; D005260:Female; D007275:Injections, Intravenous; D051379:Mice; D009207:Myoclonus / Q000139:chemically induced; D012640:Seizures / Q000139:chemically induced; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D001640:Bicuculline