Evidence for the development of tolerance to PGF2 alpha on the ethanol-induced gastric mucosal damage.
PGF2 alpha, 100 micrograms/kg intraperitoneally, applied 30 min before 1.0 ml intragastric ethanol (96%) exerts cytoprotective effect on the gastric mucosal membrane. After a week long pretreatment of the animals with 0.25; 0.5 and 1.0 mg/day PGF2 alpha resulted in a diminishing cytoprotective effect. The gastric tissue cAMP level raised simultaneously and after the PGF2 alpha pretreatment with the taming cytoprotection the cAMP level diminished parallel in a dose dependent manner. It is assumed that after PGF2 alpha pretreatment the density of the cellular PGF2 alpha receptors decreases, according to the observed phenomenon.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D015237:Dinoprost; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D011292:Premedication; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D011982:Receptors, Prostaglandin / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D011460:Prostaglandins F; D011982:Receptors, Prostaglandin; D000431:Ethanol; D015237:Dinoprost; D000242:Cyclic AMP