A dermatitis-eosinophilia syndrome. Treatment with methylprednisolone pulse therapy.
A 47-year-old man had a generalized, eczematous erythroderma and eosinophilia one week after a wasp sting. These changes persisted for four months despite intensive topical therapy and oral corticosteroids. He was then given corticosteroid pulse therapy with methylprednisolone sodium succinate (2 g, intravenously). One week later, a second pulse treatment was administered. This therapy was followed by permanent resolution of the dermatitis within two weeks.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004802:Eosinophilia / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D007299:Insect Bites and Stings / Q000150:complications; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives*; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D013577:Syndrome; D014222:Triamcinolone Acetonide / Q000627:therapeutic use; D014863:Wasps
D008776:Methylprednisolone Hemisuccinate; C038363:hydrocortisone valerate; D000324:Adrenocorticotropic Hormone; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone; D008775:Methylprednisolone