title: Profound analgesic effects of beta-endorphin in man.
abstract: Profound and long-lasting analgesia (mean duration of pain relief 33.4 h, range 22.5--73.5 h) was produced by intrathecal administration of 3 mg synthetic beta-endorphin in all of 14 patients with intractable pain due to disseminated cancer. No respiratory depression, hypotension, hypothermia, or catatonia was observed.
mesh_terms: D000328:Adult; D000368:Aged; D000700:Analgesics; D002986:Clinical Trials as Topic; D004723:Endorphins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D009619:Nociceptors / Q000187:drug effects*; D010148:Intractable Pain / Q000188:drug therapy*; D010919:Placebos; D012107:Research Design; D013997:Time Factors
chemical_list: D000700:Analgesics; D004723:Endorphins; D010919:Placebos