Pharmacokinetics of N-(4-hydroxyphenyl)-all-trans-retinamide in rats.
The concentration of N-(4-hydroxyphenyl)-all-trans-retinamide (HPR) was determined in plasma and a variety of tissues from rats after an intravenous dose (5 mg/kg). The plasma concentration-time curve could be accurately described by a triexponential equation. The apparent volume of distribution of HPR was approximately 10-12 liter/kg and the terminal half-life was 12 hr. Metabolites of HPR were more abundant than intact drug in most tissues 24 hr after the iv dose. A 5-day excretion study with radiolabeled HPR revealed that less than 2% of a single iv dose (5 mg/kg) is excreted as unmetabolized HPR in urine and feces and that most of the radioactivity is eliminated in the feces. HPR was incompletely absorbed after an oral dose (10 mg/kg).
D000818:Animals; D001646:Bile / Q000378:metabolism; D005243:Feces / Q000032:analysis; D017313:Fenretinide; D006207:Half-Life; D007700:Kinetics; D008297:Male; D051381:Rats; D014018:Tissue Distribution; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000652:urine; D014801:Vitamin A / Q000032:analysis / Q000097:blood / Q000378:metabolism* / Q000652:urine
D014801:Vitamin A; D017313:Fenretinide; D014212:Tretinoin