Host genetic control of mouse hepatitis virus type-4 (JHM strain) replication. II. The gene locus for susceptibility is linked to the Svp-2 locus on mouse chromosome 7.
Peritoneal macrophages were used to analyze host genetic control of MHV-4 infection in the 14 recombinant-inbred strains between susceptible SWR/J and resistant SJL/J progenitor strains. 4 strains were resistant to MHV-4 infection, while the remaining 10 strains were productively infected. Based upon the strain distribution pattern of susceptibility the gene locus for MHV-4 susceptibility is linked to the Svp-2 locus on the proximal end of mouse chromosome 7. This strain distribution pattern of susceptibility, and hence linkage, was determined to be identical for another MHV strain, MHV-A59. We have suggested that this locus-controlling susceptibility to MHV-4 and MHV-A59 be designated Hv-2.
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006524:Hepatitis, Viral, Animal / Q000235:genetics*; D008264:Macrophages / Q000382:microbiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000276:immunology; D006517:Murine hepatitis virus / Q000502:physiology*; D014779:Virus Replication
D005819:Genetic Markers