Modulation of the histaminergic inhibitory synaptic potential in the Onchidium neuron by cyclic nucleotides.
In the identified molluscan neuron, the presynaptic stimulation evokes a histaminergic inhibition of long duration (HILD), resulting from an increase in K conductance followed by a conductance-independent hyperpolarizing process. The latter component of HILD was enhanced by cyclic AMP but depressed by cyclic GMP. However, neither agent alone altered the resting membrane potential nor the conductance.
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D004553:Electric Conductivity; D006632:Histamine / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D008974:Mollusca; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D013997:Time Factors
D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium; D006632:Histamine; D000242:Cyclic AMP; D006152:Cyclic GMP