Mu-receptors in the C57BL mouse vas deferens.
The C57 mouse vas deferens preparation has been shown to be insensitive to mu-opioids. The present study indicates that this tissue possesses mu, d and k-receptors with similar affinities to those found in other isolated tissue preparations, but has a small receptor reserve. Thus partial agonists such as morphine are detected as antagonists.
D000818:Animals; D004361:Drug Tolerance; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D017450:Receptors, Opioid, mu; D014649:Vas Deferens / Q000378:metabolism*
D004745:Enkephalins; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D009020:Morphine