Role of oxygen radicals in ocular inflammation and cellular damage.
Oxyradicals probably play a major role in a number of specific pathological conditions of intraocular tissues, such as cataract formation and retinal degeneration. This paper reviews some of the mechanistic concepts relating to tissue damage by highly reactive oxidants derived from endogenous precursors, hydrogen peroxide and superoxide. Experimental generation of superoxide in the anterior chamber of the rabbit eye showed leucocyte infiltration to be the principal acute response occurring in 4 hr. This finding suggests that superoxide may play a significant role in the ocular inflammatory response, possibly by reacting with a precursor substance in the aqueous humor to produce a chemotactic factor as has been previously found for blood plasma.
D000818:Animals; D000867:Anterior Chamber / Q000378:metabolism; D003300:Copper / Q000633:toxicity; D005123:Eye / Q000378:metabolism; D005128:Eye Diseases / Q000378:metabolism* / Q000473:pathology; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D007962:Leukocytes; D008054:Lipid Peroxides / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D011817:Rabbits; D013481:Superoxides / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D006878:Hydroxides; D008054:Lipid Peroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D003300:Copper; D006861:Hydrogen Peroxide; D014969:Xanthine Oxidase; D010100:Oxygen