[Statistical analysis of the structure of a train of miniature endplate potentials following different treatments of the process of transmitter secretion].
The process of transmitter release has been statistically analysed with the use of a rat phrenic nerve-diaphragm preparation in which spontaneous transmitter secretion had been changed by ouabain, 4-aminopyridine and tetanus toxin. In all cases significant deviations of the statistics of miniature end-plate potentials (MEPP) impulse flows from Poisson process and amplitude distributions of MEPP from normal have been obtained. By the statistical characteristics two groups of processes have been distinguished: 1) normal and ouabain where certain consistency of the processes suggests the organization of transmitter release sites and 2) 4-aminopyridine and tetanus toxin where the temporary characteristics of the process in conjunction with the appropriate transformation of MEPP amplitude distribution apparently suggests breakdown of the mechanism of spontaneous synchronization of transmitter quanta release.
D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D005089:Exocytosis; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009045:Motor Endplate / Q000502:physiology*; D009469:Neuromuscular Junction / Q000378:metabolism / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D013744:Tetanus Toxin / Q000494:pharmacology
D000631:Aminopyridines; D018377:Neurotransmitter Agents; D013744:Tetanus Toxin; D010042:Ouabain
Statisticheskiĭ analiz struktury potoka miniatiurnykh potentsialov kontsevoĭ plastinki pri razlichnykh vozdeĭstviiakh na protsess sekretsii peredatchika.