title: On the mechanism of action of ACTH: the role of actin.
abstract: The discovery of a role for the cytoskeleton in the responses to ACTH and cyclic AMP was somewhat unexpected - at least this was the case 9 years ago (1). In fact, many endocrinologists are forced to confess that they were innocent of any understanding of the cytoskeleton and were not even aware that all mammalian cells possess microfilaments and microtubules. A new generation of endocrinologists has arrived on the scene who have been brought up with the cytoskeleton so that we can expect to see considerable progress during the coming decade in our understanding of the role of the cytoskeleton in endocrine cells.
mesh_terms: D000199:Actins / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000616:Aminoglutethimide / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D002784:Cholesterol / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology; D003572:Cytochalasins / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects / Q000378:metabolism; D003850:Deoxyribonuclease I / Q000494:pharmacology; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D010100:Oxygen
chemical_list: D000199:Actins; D003572:Cytochalasins; D000616:Aminoglutethimide; D000324:Adrenocorticotropic Hormone; D002784:Cholesterol; D000242:Cyclic AMP; D003850:Deoxyribonuclease I; D010100:Oxygen