Sequence homology between the large tumor antigen of polyoma viruses and the putative E1 protein of papilloma viruses.
The large tumor antigen of simian virus 40, mouse polyoma virus, and human BK virus is compared to the E1 protein of human and bovine papilloma viruses. It is suggested that large T and E1 are evolutionarily related and that the region of major homology forms part of an alpha/beta domain involved in nucleotide binding.
D000227:Adenine Nucleotides / Q000378:metabolism; D000263:Adenylate Kinase; D000595:Amino Acid Sequence; D000818:Animals; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D001483:Base Sequence; D001665:Binding Sites; D005075:Biological Evolution; D002417:Cattle; D006801:Humans; D051379:Mice; D027383:Papillomaviridae / Q000235:genetics*; D011120:Polyomavirus / Q000235:genetics*; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000235:genetics*
D000227:Adenine Nucleotides; D000957:Antigens, Viral, Tumor; D014764:Viral Proteins; D000263:Adenylate Kinase