title: Raised cytomegalovirus-antibody level in cerebrospinal fluid of schizophrenic patients.
abstract: The serum and cerebrospinal fluid (CSF) of 60 schizophrenic patients and 26 controls were analysed for viral antibody against cytomegalovirus (CMV), vaccinia virus, herpes simplex virus type 1 (HSV), and type A influenza virus. A CSF/serum antibody ratio more than 2 standard deviations above the mean of the controls suggested local antibody production in the central nervous system. 68% of the patients had an increased CSF/serum antibody ratio for CMV antibody, 14% for vaccinia antibody, 4% for HSV antibody, and 15% for influenza virus antibody.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis / Q000134:cerebrospinal fluid*; D001921:Brain / Q000382:microbiology; D003587:Cytomegalovirus / Q000276:immunology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000382:microbiology; D018139:Simplexvirus / Q000276:immunology; D014616:Vaccinia virus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral