[Mechanism of the immunosuppressive effect of the adrenoblocker butyroxan on development of the primary immune response].
The immunization of mice with sheep red blood cells simultaneously with the injection of Butyroxane, an alpha-adrenoblocker produced in the USSR, revealed the suppression and changes in the time course of the primary immune response. The suppression of the antibody production was shown to be caused not only by a decrease in the number of antibody-producing cells, detected in Yerne's test, but also by deceleration of their differentiation, the suppression of metabolism and functional activity.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D004146:Dioxanes / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D007166:Immunosuppressive Agents; D008297:Male; D051379:Mice; D011759:Pyrrolidines / Q000494:pharmacology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D004147:Dioxins; D007166:Immunosuppressive Agents; D011759:Pyrrolidines; C021293:butyroxan
K mekhanizmu immunosuppressivnogo vliianiia adrenoblokatora butiroksana na formirovanie pervichnogo immunnogo otveta.