Hepatic delta 9 and delta 6 desaturase activities during the recovery period following carbon tetrachloride poisoning.
The liver microsomal delta 9 and delta 6 desaturase activities have been studied in rats with carbon tetrachloride-induced hepatitis. Immediately after poisoning, significant decreases were observed for both types of desaturase activity. However, recovery kinetics were slower for the delta 6 desaturase than for the delta 9 desaturase. The activities of NADH-ferricyanide and NADH-cytochrome C reductases, proteins involved in the electron transfers associated with microsomal desaturation, were also measured. There was a fall in both activities after poisoning, but this decrease was less than that of the desaturase activities.
D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D003579:Cytochrome Reductases / Q000378:metabolism; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism
D000214:Acyl Coenzyme A; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D044943:Fatty Acid Desaturases; D013230:Stearoyl-CoA Desaturase; D003579:Cytochrome Reductases