Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide into the rat nucleus accumbens attenuates brain stimulation reward.
Microinjections of nanogram amounts of sulfated cholecystokinin octapeptide (CCK-8S) into the nucleus accumbens were examined for effects on intracranial self-stimulation (ICSS) derived from the ventral tegmental area (VTA). The results showed that CCK-8S dose-dependently antagonized VTA intracranial self-stimulation (ICSS) without affecting maximum response rates. CCK-8S also increased the current threshold required for ICSS. These findings were interpreted to suggest that CCK-8S attenuates brain stimulation reward derived from the VTA.
D000818:Animals; D004298:Dopamine / Q000502:physiology; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology; D012686:Septal Nuclei / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology* / Q000502:physiology; D009435:Synaptic Transmission; D013681:Tegmentum Mesencephali / Q000502:physiology*
D012844:Sincalide; D004298:Dopamine