[Characteristics of glucose metabolism in rats with different preferences for alcohol].
Rats preferring ethanol were distinct from water-consuming animals in a decreased level of immunoreactive insulin im blood serum as well as in glucokinase activity of liver tissue. Per oral loading with glucose, 4 g/kg of body mass, enabled to detect a difference in the sugar phosphorylation via hexokinase and glucokinase reactions as well as the dissimilar sensitivity of the insulin system to glucose in the ethanol-, water-consuming and intermediate animals. Ethanol-consuming rats were more resistant to the effect of starvation during 48 hrs. The data obtained suggest that the characteristic properties of glucose metabolism in ethanol-consuming rats appear to be responsible for increased consumption of ethanol, which is used as optimal energy source, metabolized via pathways which did not involve the glycolytic pathway.
D000428:Alcohol Drinking; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism; D005941:Glucokinase / Q000097:blood; D005952:Glucose-6-Phosphatase / Q000097:blood; D006593:Hexokinase / Q000097:blood; D007328:Insulin / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010766:Phosphorylation; D051381:Rats; D013217:Starvation
D001786:Blood Glucose; D007328:Insulin; D000431:Ethanol; D006593:Hexokinase; D005941:Glucokinase; D005952:Glucose-6-Phosphatase
Osobennosti obmena gliukozy u krys s razlichnoĭ alkogol'noĭ motivatsieĭ.