title: Conformational studies of somatostatin and selected analogues by Raman spectroscopy.
abstract: Laser Raman spectroscopy has been used to study the conformations of somatostatin and some selected analogues in aqueous solution. The results indicate that the CS-SC dihedral angles of somatostatin and of these analogues (except [Ala3,14]-SS, which has no disulfide bond) are within 20 degrees of +/- 85 degrees, and the SS-CC dihedral angles are predominantly in the range of 50 degrees-180 degrees. Furthermore, from the behavior of the amide I' and amide III bands, it appears that somatostatin adopts a beta-pleated sheet structure, whereas its analogues are less ordered (to varying degrees).
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D011487:Protein Conformation; D051381:Rats; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013059:Spectrum Analysis, Raman
chemical_list: C027164:somatostatin, Ala(3,14)-; D013004:Somatostatin; C027163:somatostatin, des-Asn(5)-; C017783:somatostatin, Trp(8)-; C027165:somatostatin, Ser(13)-; C020878:somatostatin, Cys(3)-