Naloxone inhibits the plasma epinephrine response to ACTH but not to 2-deoxy-D-glucose in rats.
Intravenous injection of (1-24) ACTH and 2-deoxy-d-glucose (2DG) stimulated the plasma epinephrine and norepinephrine levels in pentobarbital-anesthetized male rats. Naloxone, a specific opiate antagonist, inhibited the plasma epinephrine response to ACTH but not to 2DG. Norepinephrine release induced by ACTH or 2DG was not affected by naloxone. These results suggest that the opioid peptidergic synapse might be involved in the ACTH- but not in the 2DG-induced epinephrine release.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D003366:Cosyntropin / Q000037:antagonists & inhibitors*; D003837:Deoxy Sugars / Q000037:antagonists & inhibitors*; D003847:Deoxyglucose / Q000037:antagonists & inhibitors*; D004723:Endorphins / Q000502:physiology; D004837:Epinephrine / Q000097:blood*; D007275:Injections, Intravenous; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D003837:Deoxy Sugars; D004723:Endorphins; D003366:Cosyntropin; D009270:Naloxone; D000324:Adrenocorticotropic Hormone; D003847:Deoxyglucose; D009638:Norepinephrine; D004837:Epinephrine