Stimulation of the pituitary-adrenocortical axis and induction of tyrosine hydroxylase by nerve growth factor are not dependent on mouse submaxillary gland isorenin.
A biologically active 2.5S NGF preparation free of renin-activity was prepared. Stimulation of the hypothalamo-pituitary-adrenocortical axis as well as induction of tyrosine hydroxylase in sympathetic ganglia are characteristic NGF effects and are not mediated by renin. These findings are confirmed by observations showing that captopril, an angiotensin converting enzyme inhibitor, failed to block these responses.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D004326:Drinking / Q000187:drug effects; D010450:Endopeptidases / Q000502:physiology*; D004790:Enzyme Induction / Q000187:drug effects; D005728:Ganglia, Sympathetic / Q000201:enzymology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D013363:Submandibular Gland / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis*
D009414:Nerve Growth Factors; D000324:Adrenocorticotropic Hormone; D014446:Tyrosine 3-Monooxygenase; D010450:Endopeptidases; C015306:iso-renin