[Effect of GABA-negative preparations on the anxiolytic and sedative effects of diazepam].
Experiments on rats have shown that bicuculline (2 mg/kg) and picrotoxin (2 mg/kg) abolish the anxiolytic action of diazepam (2.5 mg/kg). Bicuculline (2 and 4 mg/kg) decreases while picrotoxin transforms the sedative effect of diazepam to the anxiolytic one. Picrotoxin (2 mg/kg) reduces the sedative action of gamma-acetylenic GABA (100 mg/kg) but does not favour the manifestation of its anxiolytic effect. It is suggested that the GABA-ergic mechanisms play an important role in the sedative effect of diazepam.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001640:Bicuculline / Q000008:administration & dosage*; D003975:Diazepam / Q000008:administration & dosage*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D010852:Picrotoxin / Q000008:administration & dosage*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D014151:Anti-Anxiety Agents; D001640:Bicuculline; D003975:Diazepam; D006993:Hypnotics and Sedatives; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid
Vliianie GAMK-negativnykh preparatov na anksioliticheskiĭ i sedativnyĭ éffekty diazepama.