In vivo induction of tumor-specific immunity by glycolipid extracts of SV40-transformed cells.
Glycolipid extracts were prepared from various Syrian golden hamster cell lines, either SV40-transformed or spontaneously transformed. To detect possible SV40-TSTA activity of the glycolipid preparations, normal hamsters were inoculated with different glycolipid extracts and were subsequently challenged with an SV40 tumor-cell line. Significant immunoprotection against SV40 tumor challenge was induced with glycolipids obtained from SV40-transformed cell lines. This was expressed as complete tumor rejection or as a decrease in tumor growth rate, when compared to controls. No protective effects were induced with glycolipid extracts from spontaneously transformed cells. Results suggest that tumor-specific glycolipids synthesized in cells transformed by SV40 virus could act as tumor transplantation antigens responsible for specific tumor rejection in syngeneic hosts.
D000818:Animals; D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000276:immunology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D002472:Cell Transformation, Viral; D006224:Cricetinae; D006017:Glycolipids / Q000276:immunology* / Q000302:isolation & purification; D007109:Immunity; D007114:Immunization; D008647:Mesocricetus; D013539:Simian virus 40 / Q000276:immunology*; D014181:Transplantation Immunology; D014412:Tumor Virus Infections / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*
D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D006017:Glycolipids; D014764:Viral Proteins