A micro-computerised system to measure the colonic contractile activity: application to pharmacological tests in dogs.
This paper describes a rapid and reproducible technique for measuring the contractile activity of the colon, from strain-gauge signals, using a microcomputer data-processing PDS M 6800. This system can be used on-line, or after a 32 times compression, with only slight modifications of the data collection program. The motility index of the colon, calculated from the surface of the contractile waves, was automatically given at 5-min intervals. A series of comparative measurements of colonic motility and its changes after administration of drugs, such as morphinomimetics and spasmolytics, have been reported.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003201:Computers; D004285:Dogs; D004594:Electrophysiology; D005769:Gastrointestinal Motility / Q000187:drug effects; D007422:Intestines / Q000502:physiology*; D008139:Loperamide / Q000494:pharmacology; D008838:Microcomputers; D009020:Morphine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009269:Nalorphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology
D011759:Pyrrolidines; D009270:Naloxone; D008139:Loperamide; D009020:Morphine; D001285:Atropine; D009269:Nalorphine