Recurrent acute renal failure due to nonaccidental poisoning with glafenin in a child.
A 7-year-old boy experienced recurrent attacks of acute renal failure over an 18 month period. Each attack was accompanied by a fluorescent yellow discoloration of his urine. Laboratory data and the kidney biopsy were consistent with acute tubulo-interstitial nephritis. Repeated contacts with the boy in a play setting and thorough toxicologic examination of his urine finally led to the conclusion that the mother systematically poisoned her child with glafenin. The clinical and experimental literature on glafenin-related disease is reviewed. This is the first report of glafenin intoxication in a child. This is also the first case of kidney disease as an expression of child abuse.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000652:urine; D002648:Child; D002649:Child Abuse; D005897:Glafenine / Q000506:poisoning* / Q000652:urine; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced / Q000652:urine; D012008:Recurrence; D062367:ortho-Aminobenzoates / Q000506:poisoning*
D062367:ortho-Aminobenzoates; D005897:Glafenine