[Neuropharmacologic regulation of the carcinogenic action of 1,2-dimethylhydrazine].
Chronic experiments were made on 100 male rats to examine the modifying effects of adrenergic and cholinergic agents that regulate homeostasis on 1,2-dimethylhydrazine-induced intestinal carcinogenesis. The sympatholytic guanethidine (5 mg/kg) and the alfa-adrenoblocker butyroxan (2.5 mg/kg) did not influence the carcinogenesis in the intestine. The noradrenaline- and atropine-induced (1 mg/kg and 10 mg/kg) increase in the adrenergic component of the vegetative nervous system led to the decrease in the number (by 2-3 times) and size of the tumor nodes in the intestine. The drugs did not affect the morphology of neoplasms. The results are discussed in terms of essential importance of the vegetative nervous system in the mechanism of chemical carcinogenesis.
D019813:1,2-Dimethylhydrazine; D000317:Adrenergic alpha-Antagonists; D000818:Animals; D001285:Atropine; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002273:Carcinogens / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000503:physiopathology; D004127:Dimethylhydrazines / Q000494:pharmacology*; D004146:Dioxanes; D006145:Guanethidine; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009638:Norepinephrine; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D002273:Carcinogens; D004127:Dimethylhydrazines; D004146:Dioxanes; D008763:Methylhydrazines; C021293:butyroxan; D001285:Atropine; D019813:1,2-Dimethylhydrazine; D009638:Norepinephrine; D006145:Guanethidine
Neĭrofarmakologicheskaia reguliatsiia kantserogennogo deĭstviia 1,2-dimetilgidrazina.