Inhibition of postreplication recombinational repair by DNA-gyrase antagonists in Escherichia coli.
In the present study we investigated the possible involvement of DNA-Gyrase in postreplication repair in E. Coli. It was observed that nalidixic acid and oxolinic acid (which are known-antagonists of DNA-Gyrase) inhibited recombinational repair. These results strongly suggest that the nicking closing activity of DNA-Gyrase is essential for efficient recombinational repair.
D049933:Aminocoumarins; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D003374:Coumarins / Q000494:pharmacology; D004260:DNA Repair; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D009268:Nalidixic Acid / Q000494:pharmacology; D010093:Oxolinic Acid / Q000494:pharmacology; D011995:Recombination, Genetic; D059005:Topoisomerase II Inhibitors
D049933:Aminocoumarins; D001426:Bacterial Proteins; D003374:Coumarins; D004269:DNA, Bacterial; D059005:Topoisomerase II Inhibitors; D009268:Nalidixic Acid; D010093:Oxolinic Acid; C004628:coumermycin