Beta-carboline kindling of the benzodiazepine receptor.
Beta-Carboline (norharman), an antagonist of the benzodiazepine receptor, given daily at a dose of 20 mg/kg (i.p.), produces kindled seizures. The mechanism of this epileptogenesis is unknown; however, other ligands of the benzodiazepine receptor, i.e. diazepam, R015-1788 and CL218-872 block the expression of kindled seizures in a dose-dependent manner. The results suggest that beta-carboline kindling is mediated through the benzodiazepine receptor.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002243:Carbolines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D005442:Flumazenil; D007211:Indoles / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*
D001570:Benzodiazepinones; D002243:Carbolines; D003292:Convulsants; D007211:Indoles; D011724:Pyridazines; D011963:Receptors, GABA-A; D005442:Flumazenil; C021604:CL 218872; D003975:Diazepam