Distribution in tissues and effects by acute hypoxia on angiotensin I converting enzyme activity in guinea pig and chicken.
Angiotensin I converting enzyme activity was measured in homogenates of guinea pig and chicken organs (lung, kidney, heart, ileum, diaphragm and liver), using a spectrophotometric assay for hydrolysis of hippuryl-L-histidyl-L-leucine. High specific activities were found in lung, kidney and diaphragm, but the highest corresponded to guinea pig lung and chicken kidney. Acute hypoxia decreased angiotensin I converting enzyme activity in guinea pig lung and chicken diaphragm, but the changes in kidney were considered non-significant in both the guinea pig and chicken.
D000818:Animals; D002645:Chickens; D003964:Diaphragm / Q000201:enzymology; D004285:Dogs; D006168:Guinea Pigs; D000860:Hypoxia / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D051379:Mice; D007703:Peptidyl-Dipeptidase A / Q000032:analysis*; D011817:Rabbits; D013045:Species Specificity
D007703:Peptidyl-Dipeptidase A