Isolation, synthesis, and pharmacology of metabolites of 1-(3,4-dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone.
The metabolism of 1-(3,4-dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone, an antianxiety/antidepressant agent, in dogs is reported. Two metabolites, 3-[1-(3,4-dichlorobenzyl)-1-ureido]propanoic acid and 1-(3,4-dichlorobenzyl)uracil, were isolated, characterized, and synthesized. Neither metabolite was acutely toxic, and they did not exhibit antidepressant or antianxiety/anticonvulsant activity.
D000818:Animals; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D005260:Female; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011744:Pyrimidinones / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D013747:Tetrabenazine / Q000037:antagonists & inhibitors
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D011744:Pyrimidinones; C026983:1-(3,4-dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone; D010433:Pentylenetetrazole; D013747:Tetrabenazine