gamma-Glutamyl transpeptidase in isolated brain endothelial cells: induction by glial cells in vitro.
The endothelia of microvessels isolated from mouse brain by mechanical means are rich in gamma-glutamyl transpeptidase; however, the enzyme often disappears when the cells migrate or proliferate from the microvessel isolates. In an endothelial cell line derived from similar isolates and negative for gamma-glutamyl transpeptidase, the enzyme could be induced in the endothelial cells when they were cocultured with glial cells. Thus there may be a requirement for continuous induction of gamma-glutamyl transpeptidase in brain microvessels by adjacent glial cells.
D000818:Animals; D001921:Brain / Q000098:blood supply*; D002196:Capillaries / Q000201:enzymology*; D002478:Cells, Cultured; D004727:Endothelium / Q000201:enzymology; D004790:Enzyme Induction; D005910:Glioma / Q000503:physiopathology; D051379:Mice; D009457:Neuroglia / Q000502:physiology*; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D005723:gamma-Glutamyltransferase