Immune-complex glomerulopathy in patients treated with captopril.
Renal biopsies were performed on 13 patients treated with captopril. In 4 patients findings indicated an early stage of membranous glomerulopathy (MGP). In the other patients electron microscopy showed scanty small subepithelial deposits and immunofluorescence revealed a patchy granular pattern along the glomerular basement membrane. One of the 4 patients with MGP presented with nephrotic syndrome and another with serum-sickness-like syndrome. None of the other patients, including 2 with MGP, had proteinuria or deterioration of renal function. Thus captopril may be associated with the development of immune-complex glomerulopathy.
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001706:Biopsy; D002216:Captopril / Q000009:adverse effects* / Q000276:immunology; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007105:Immune Complex Diseases / Q000139:chemically induced*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced*; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000139:chemically induced; D011392:Proline / Q000031:analogs & derivatives*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D004247:DNA; D011392:Proline; D002216:Captopril