Evaluation of antiviral substances against influenza A virus strains by the haemadsorption reduction test.
The haemadsorption reduction test with Ehrlich mouse ascites tumour cells proved to be a simple method for testing the sensitivity of influenza A virus strains to antiviral substances. Ribavirin and 2-deoxy-D-glucose were poorly effective in this system while all virus strains except A/PR/8/34 (H0N1) were highly sensitive to amantadine and rimantadine, the latter being the strongest inhibitor.
D000547:Amantadine / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006383:Hemadsorption Inhibition Tests; D009980:Influenza A virus / Q000187:drug effects*; D008828:Microbiological Techniques; D012254:Ribavirin / Q000494:pharmacology; D012299:Rimantadine / Q000494:pharmacology
D000998:Antiviral Agents; D012299:Rimantadine; D012254:Ribavirin; D003847:Deoxyglucose; D000547:Amantadine