Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.
Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid chromatography (HPLC). Direct microtechniques for sequence determination were used to establish its structure. Urotensin II from Gillichthys is a 1363-dalton dodecapeptide with the amino acid sequence Ala-Gly-Thr-Ala-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val. This sequence is homologous with somatostatin in positions 1 and 2 and 7-9. The sequence has been verified by the production of a bioactive synthetic urotensin II. The possible chemical and physiological significance of its homology to somatostatin is discussed.
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005399:Fishes / Q000502:physiology*; D009490:Neurosecretory Systems / Q000032:analysis*; D010455:Peptides / Q000302:isolation & purification*; D013004:Somatostatin / Q000032:analysis; D013329:Structure-Activity Relationship; D014579:Urotensins / Q000302:isolation & purification*
D010455:Peptides; D014579:Urotensins; D013004:Somatostatin