Propranolol--a medical treatment for portal hypertension?
Continuous, oral administration of propranolol at doses which reduced the heart-rate by 25% produced a sustained decrease in portal venous pressure in cirrhotic patients with portal hypertension. This effect of propranolol might be useful in preventing recurrent bleeding due to ruptured oesophageal varices in patients with portal hypertension.
D000284:Administration, Oral; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D004932:Esophageal and Gastric Varices / Q000150:complications; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy*; D008102:Liver Circulation / Q000187:drug effects; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D014690:Venous Pressure / Q000187:drug effects
D011433:Propranolol