Hormonal influences on the secretion of steroid-binding proteins by a human hepatoma-derived cell line.
We examined the influence of numerous substances on the secretion of corticosteroid-binding globulin (CBG) and testosterone-estradiol binding globulin (TeBG) by a human hepatoma-derived cell line. Thyroxine, at physiologic concentrations, resulted in an increased secretion of TeBG but not CBG. Estrogens, antiestrogens, and androgens were without effect on either of these binding proteins.
D000818:Animals; D006528:Carcinoma, Hepatocellular; D002460:Cell Line; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms; D051381:Rats; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*; D014156:Transcortin / Q000378:metabolism*
D012738:Sex Hormone-Binding Globulin; D004958:Estradiol; D014156:Transcortin; D013974:Thyroxine