[Effect of indomethacin and nonachlazine on myocardial and cerebral tyrosine hydroxylase activity in rats].
Nonachlazin (6 mg/kg) and indomethacin (10 mg/kg) intraperitoneally have a unidirectional effect on the activity of tyrosin hydroxylase, reducing it in the hypothalamus and in the brain stem and increasing it in the heart septum. In the brain, the effects of nonachlazin and indomethacin are not summarized whereas in the heart their effects are summarized. Unlike indomethacin, nonachlazin exerts a direct effect on the rate of tyrosin hydroxylase reaction but has no effect on the activity of cyclooxygenase and on synthetase of prostaglandins. It is concluded that prostaglandins produce a modulating action on the activity of brain and heart tyrosine hydroxylase and participate in the mechanism of action of nonachlazin.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D006346:Heart Septum / Q000201:enzymology*; D007031:Hypothalamus / Q000201:enzymology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D009628:Nonachlazine / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D010640:Phenothiazines; D009628:Nonachlazine; D014446:Tyrosine 3-Monooxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D007213:Indomethacin
Vliianie indometatsina i nonakhlazina na aktivnost' tirozingidroksilazy v miokarde i golovnom mozge krys.