The importance of human intestinal diamine oxidase in the oxidation of histamine and/or putrescine.
Histamine, naturally methylated histamine and putrescine are good substrates for human intestinal diamine oxidase, N-Methyl-N-formylhydrazine, the constituent of the mashroom poison-gyromitrin is an inhibitor of human intestinal diamine oxidase. Burimamide inhibits more effectively mammalian intestinal diamine oxidases than pea seedling diamine oxidase, beta-aminopropionitrile is a better inhibitor of pea seedling enzyme than mammalian diamine oxidases. This inhibitory differences might be related to preference in histamine or putrescine oxidizing activity of these enzymes.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000629:Aminopropionitrile / Q000494:pharmacology; D006632:Histamine / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D007422:Intestines / Q000201:enzymology*; D011700:Putrescine / Q000378:metabolism*
D006635:Histamine H2 Antagonists; D006834:Hydrazines; D000629:Aminopropionitrile; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D011700:Putrescine