Transport in quantitative structure-activity relationships. VI: Relationship between transport rate constants and partition coefficients.
The transport rate constant of a drug partitioned in a two-phase system from an aqueous to an organic phase (k1obs) and vice versa (k2obs) is a function of the partition coefficient P and of a solvent system-dependent parameter beta. Drug transport is shown to be independent of molecular structure for a number of arbitrary compounds.
D001692:Biological Transport; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010599:Pharmacokinetics; D012995:Solubility; D013329:Structure-Activity Relationship
D004364:Pharmaceutical Preparations