Somatostatin-28: selective action on the pancreatic beta-cell and brain.
Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS-14) to inhibit acutely insulin secretion induced by arginine in vivo; SS-28 is only 3 times as potent as SS-14 to inhibit glucagon secretion induced by arginine. D-Trp substitution in position 28 of SS-28 increase potency to 2600 times that of SS-14 for inhibition of arginine induced insulin secretion. SS-28 in 10 and [D-Trp22]-SS-28 is 100 times as potent as SS-14 to act within the central nervous system to inhibit bombesin induced hyperglycemia. SS-28 compared to SS-14 shows pancreatic beta-cell and brain selectivity of action.
D000818:Animals; D001120:Arginine / Q000037:antagonists & inhibitors; D001786:Blood Glucose / Q000378:metabolism; D001839:Bombesin / Q000037:antagonists & inhibitors; D001921:Brain / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011498:Protein Precursors / Q000494:pharmacology*; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*; D053561:Somatostatin-28
D001786:Blood Glucose; D007328:Insulin; D011498:Protein Precursors; D013004:Somatostatin; D053561:Somatostatin-28; D001120:Arginine; D001839:Bombesin; D004837:Epinephrine