Tissue specificity for the effect of estrogen on lipogenic activity in male and female rats.
Estrogen treatment decreased fatty acid synthetase and acetyl-CoA carboxylase (EC 6.4.1.2) activities and lowered the lipogenic capacity of mammary gland and the hormone-responsive, transplantable mammary adenocarcinoma R3230AC in male and female Fischer rats whereas the activity of these enzymes and the lipogenic capacity were increased in liver. Estrogen increased the activity of thioesterase II, an enzyme which terminates fatty acid synthesis at medium chain lengths, in both normal and neoplastic mammary tissue.
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000230:Adenocarcinoma / Q000201:enzymology*; D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D064429:Fatty Acid Synthases / Q000378:metabolism; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008321:Mammary Glands, Animal / Q000187:drug effects; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D051381:Rats; D012737:Sex Factors; D013869:Thiolester Hydrolases / Q000378:metabolism
D004958:Estradiol; D064429:Fatty Acid Synthases; D013869:Thiolester Hydrolases; C022738:thioesterase II; D000103:Acetyl-CoA Carboxylase