Comparative study of four antacids.
Four antacid preparations have been studied in a stratified, randomized, double-blind trial to evaluate criteria which determine patients' acceptance of this type of therapy. There was a considerable range of judgements about palatability, but preference was determined not only by factors such as the smell, taste, texture and after-taste of the preparation, but also by the order in which the antacids were tested and by the age and sex of the patient. The preparations also differed considerably in acid-neutralizing capacity and ability to bind bile salts, as well as cost. We conclude that individuals requiring antacid therapy should be allowed to chose from among a range of preparations, in order to maximize compliance.
D000328:Adult; D000368:Aged; D000464:Alginates / Q000627:therapeutic use*; D017607:Aluminum Compounds; D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D000538:Aluminum Silicates / Q000627:therapeutic use*; D000863:Antacids / Q000627:therapeutic use*; D001639:Bicarbonates / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004129:Dimethylpolysiloxanes; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D004941:Esophagitis / Q000188:drug therapy; D005260:Female; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use*; D017616:Magnesium Compounds; D008276:Magnesium Hydroxide / Q000627:therapeutic use*; D008277:Magnesium Oxide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D010437:Peptic Ulcer / Q000188:drug therapy; D011897:Random Allocation; D017640:Silicates; D012824:Silicic Acid / Q000627:therapeutic use*; D012822:Silicon Dioxide / Q000627:therapeutic use*; D012828:Silicones / Q000627:therapeutic use*; D012841:Simethicone / Q000627:therapeutic use*; D017693:Sodium Bicarbonate
D000464:Alginates; D017607:Aluminum Compounds; D000538:Aluminum Silicates; D000863:Antacids; D001639:Bicarbonates; D004129:Dimethylpolysiloxanes; D004338:Drug Combinations; D017616:Magnesium Compounds; D017640:Silicates; D012828:Silicones; C023473:aluminium hydroxide, magnesium oxide, simeticone drug combination; D012824:Silicic Acid; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D008277:Magnesium Oxide; D000536:Aluminum Hydroxide; C007829:alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; C033065:aluminum magnesium silicate; D012822:Silicon Dioxide; D012841:Simethicone; D017693:Sodium Bicarbonate; D008274:Magnesium; D008276:Magnesium Hydroxide