title: Neurophysiological evidence for different types of depression.
abstract: A brief, selective review of a broad range of evidence bearing upon biological distinctions between neurotic and psychotic forms of depression is presented. It includes a somewhat detailed presentation of clinical neurophysiological findings obtained in the author's laboratory over three decades of research. The available evidence is taken to support the discontinuity position of the continuity-discontinuity controversy about neurotic vs psychotic depression. It is concluded that more than one process underlies clinical depression, and that there may be several kinds of depressive disorders.
mesh_terms: D000341:Affective Disorders, Psychotic / Q000175:diagnosis* / Q000503:physiopathology; D000654:Amobarbital; D001143:Arousal / Q000502:physiology; D001341:Autonomic Nervous System / Q000503:physiopathology*; D003866:Depressive Disorder / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012684:Sensory Thresholds; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D018377:Neurotransmitter Agents; D000654:Amobarbital