Effect of 9-(S)-(2,3-dihydroxypropyl)adenine on experimental rabies infection in laboratory mice.
9-(S)-(2,3-dihydroxypropyl)adenine (DHPA) exerted a pronounced influence on experimental rabies infection in laboratory mice. It was effective in a dose range from 1 to 100 mg/kg body weight. Intracerebral infection tended to be potentiated, intramuscular infection was partly or fully inhibited by the drug. Peroral administration was the most effective. The results of individual experiments varied and depended on the sensitivity of the virus strains employed, the dose of DHPA given and the time pattern of its administration.
D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000284:Administration, Oral; D000818:Animals; D051379:Mice; D011818:Rabies / Q000188:drug therapy*; D011820:Rabies virus / Q000254:growth & development
C016391:9-(2,3-dihydroxypropyl)adenine; D000225:Adenine