Kaposi's sarcoma: presence of herpes-type virus particles in a tumor specimen.
Three Kaposi's sarcoma biopsy specimens obtained from three African patients with typical nodular cutaneous tumors were investigated morphologically for cellular modifications suggestive of a viral origin. In one case a Kaposi's sarcoma cell of the endothelial type contained a few intranuclear herpes-type viral inclusions. The present findings complement previous reports of herpes-type viral particles in Kaposi's sarcoma cultured cell lines and suggest that, at least under certain conditions, Kaposi's sarcoma cells enter a virus-producing phase.
D002467:Cell Nucleus / Q000648:ultrastructure; D006225:Hand; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D007866:Leg; D008297:Male; D012514:Sarcoma, Kaposi / Q000648:ultrastructure*; D018139:Simplexvirus; D012878:Skin Neoplasms / Q000648:ultrastructure*