title: [Anaplastic transformation of well differentiated carcinoma of the thyroid].
abstract: Four cases of thyroid cancer with anaplastic transformation are reported. The anaplastic transformed cancers were found as a metastatic lesion 3-37 years after the resection of well-differentiated thyroid cancers. In one case, anaplastic cancer was mixed with well-differentiated cancer in an old metastatic focus but not present in the partially removed hyalinized primary lesion. The role of radiation therapy in anaplastic transformation was discussed.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D000368:Aged; D002277:Carcinoma / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery