In vitro actions of ranitidine, a new histamine H2-receptor antagonist.
Ranitidine has been tested on isolated guinea-pig right atrium and rat uterine horn, tissues known to possess histamine H2-receptors; and on isolated guinea-pig ileum a tissue containing histamine H1-receptors. These experiments have shown ranitidine to be a potent competitive antagonist of histamine at H2-receptor sites in vitro. This action is selective since high concentrations of ranitidine do not affect beta-adrenoceptor, histamine H1-receptor and muscarinic receptor mediated responses.
D000818:Animals; D005260:Female; D005663:Furans / Q000494:pharmacology*; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011899:Ranitidine; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects
D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine