Lack of correlation between complications after smallpox vaccination and the ABO blood-group system.
Blood group [ABO system] distribution was analysed in 245 children with complications after smallpox vaccination. One hundred and thirty-two children had neurological and 113 and skin or mucosal complications. 41.6% of the children were blood-group A or AB. 58.4% were blood group O or B, which was not a significant difference from the normal population [44.7%---48.7% and 51.0%---55.9%, respectively]. The analysis did not show in persons possessing blood groups A or AB an enhanced susceptibility to complications following antismallpox immunization or to particularly severe clinical forms of these complications. Immunological advantages in persons with blood group O or B were not found either.
D000017:ABO Blood-Group System; D002648:Child; D002675:Child, Preschool; D004673:Encephalomyelitis, Acute Disseminated / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D009500:Neutralization Tests; D012877:Skin Manifestations; D012900:Smallpox Vaccine / Q000009:adverse effects*; D014611:Vaccination; D014616:Vaccinia virus / Q000276:immunology
D000017:ABO Blood-Group System; D007518:Isoantibodies; D012900:Smallpox Vaccine