[Effect of calcium blockers on the morphofunctional state of the capillary system of the cerebral cortex].
The use of the non-injection method for determination of the intraorgan microcirculatory bed in cats has shown that calcium channels play an important role in the functioning of precapillary sphincters, whose activity depends to a greater extent on the activity of alpha-adrenoreceptors, particularly alpha 1-receptors. The so-called "gaiting mechanism" of calcium channels plays a more essential part in the changes in the basal tone of precapillary sphincters influenced by calcium antagonists, whereas voltage-controlled and receptor-operated calcium channels are responsible for variations in the adrenergic tone of precapillary sphincters.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002196:Capillaries / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D002415:Cats; D002540:Cerebral Cortex / Q000098:blood supply* / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
D002121:Calcium Channel Blockers; D007473:Ion Channels; D002118:Calcium; D009638:Norepinephrine
Vliianie blokatorov kal'tsiia na morfofunktsional'noe sostoianie kapilliarnoĭ sistemy kory golovnogo mozga.