Antiproliferative activity of doxorubicin and aminoanthraquinone derivatives on Chinese hamster ovary cells.
A study of the antiproliferative activity of doxorubicin and several substituted aminoanthraquinone derivatives on Chinese hamster ovary cells was conducted. Doxorubicin and a derivative each inhibited cell proliferation at low concentrations, the latter being more potent than doxorubicin. A structure-activity relationship of these compounds is discussed in connection with an earlier postulated N-O-O triangulation hypothesis.
D000818:Animals; D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016466:CHO Cells; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D006224:Cricetinae; D004317:Doxorubicin / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology*
D000880:Anthraquinones; D006131:Growth Inhibitors; D004317:Doxorubicin