Indomethacin inhibits the in vivo formation of the lipoxygenase product HETE (12-hydroxy-5,8,10,14-eicosatetraenoic acid) during granulomatous inflammation in the rat.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D001095:Arachidonic Acids / Q000096:biosynthesis* / Q000378:metabolism; D002351:Carrageenan / Q000494:pharmacology; D006099:Granuloma / Q000139:chemically induced / Q000201:enzymology*; D007213:Indomethacin / Q000494:pharmacology*; D007249:Inflammation / Q000201:enzymology*; D016859:Lipoxygenase Inhibitors; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D001095:Arachidonic Acids; D016859:Lipoxygenase Inhibitors; D011458:Prostaglandins E; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D002351:Carrageenan; D007213:Indomethacin