[Comparative activity of dibekacin and several cephalosporins on Pseudomonas aeruginosa].
Dibekacin is a semisynthetic aminonglycoside derivative of kanamicin B, with highly activity against most gram-positive and gramnegative bacteria. It is also active against bacteria relatively resistant to other antibiotics. Since Pseudomonas aeruginosa seems to be the most common strain recent clinical isolated, we compared the in vitro activity of dibekacin with other eigh cephalosporins against 579 clinical isolates of sensitive and gentamicin-carbenicillin resistant Pseudomonas aeruginosa. The results indicate that dibekacin was more active than any of the other antibiotics tested against all the organisms tested, including carbenicillin-resistant Pseudomonas aeruginosa.
D002435:Cefamandole / Q000494:pharmacology; D002438:Cefoperazone / Q000494:pharmacology; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000494:pharmacology; D002441:Cefsulodin / Q000494:pharmacology; D002443:Ceftriaxone; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D003982:Dibekacin / Q000494:pharmacology*; D007612:Kanamycin / Q000031:analogs & derivatives*; D009070:Moxalactam / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D002511:Cephalosporins; D003982:Dibekacin; D007612:Kanamycin; D002435:Cefamandole; D002443:Ceftriaxone; D002438:Cefoperazone; D002439:Cefotaxime; D002444:Cefuroxime; D002441:Cefsulodin; D009070:Moxalactam
Attivita' comparativa in vitro della dibekacina e di alcune cefalosporine su Pseudomonas aeruginosa.