[Dye concentration measurements for the determination of leakage during and following normothermic cytostatic perfusion in the treatment of tumors of the extremities].
The regional normothermic cytostatic perfusion with 3000 mg Methotrexate and 1.5 mg Vincristine under rescue conditions (leucovorine) during 120 minutes was carried out in patients with malignant melanoma stage II by Sylven or other tumors of the lower extremities in the surgical university hospital Halle since 1980. Dye concentration measurements with indigo carmine for monitoring the isolation between systemic circulation and perfusion circulation were carried out during and after cytostatic perfusion. The measurements took place with a Spekol 10 of the VEB Carl Zeiss, Jena, by wave-length of 605 nm. The leakage streams of 30 perfusions amounted from 0 to 46% during the phase - regional perfusion. The dye quantity which was secreted by the kidneys during 16 hours post perfusion despite plentiful lavage of the extremity (MTX quantity) amounted from 2 to 7%.
D010478:Chemotherapy, Cancer, Regional Perfusion; D005121:Extremities; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy*; D006801:Humans; D007203:Indigo Carmine / Q000097:blood*; D007211:Indoles / Q000097:blood*; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D008727:Methotrexate / Q000378:metabolism* / Q000627:therapeutic use; D012516:Osteosarcoma / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*; D013053:Spectrophotometry; D014750:Vincristine / Q000627:therapeutic use
D007211:Indoles; D014750:Vincristine; D007203:Indigo Carmine; D008727:Methotrexate
Farbstoffkonzentrationsmessungen zur Abstrombestimmung während und nach der normothermen zytostatischen Perfusion zur Behandlung von Extremitätentumoren.