Decrease by glucagon in peroxide generation by isolated hepatocytes.
Exposure of isolated rat liver cells to glucagon or dibutyryl cyclic AMP leads to a prompt decrease in the rate of cellular peroxide generation as evidenced by (i) a reduced rate of [14C]formate oxidation and (ii) a lowered steady-state concentration of catalase Compound I.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D005561:Formates / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D005561:Formates; C030544:formic acid; D003994:Bucladesine; D005934:Glucagon; D006861:Hydrogen Peroxide; D002374:Catalase