Intraductal infusion of mono-octanoin: experience in 24 patients with retained common-duct stones.
Mono-octanoin (glyceryl-l-mono-octanoate), 2-4 ml/h, was instilled into the bile or hepatic ducts of twenty-four patients with retained gallstones after cholecystectomy and choledochotomy. After treatment, fifteen patients no longer had stones. In five the stones were smaller or reduced in number; and in four of these the stones were extracted mechanically via the T-tube tract. Mechanical extraction was also possible in one of the four patients with unaltered stones. With a battery-operated pump or hand injection, mono-octanoin can be safely infused as early as the 8th postoperative day and some patients can continue the treatment outside hospital.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001653:Bile Ducts, Intrahepatic; D002210:Caprylates; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D042882:Gallstones / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D005989:Glycerides / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D012997:Solvents
D002210:Caprylates; D005989:Glycerides; D012997:Solvents; D002784:Cholesterol; C025343:monooctanoin