Beta-endorphin. Binding activity of synthetic analogs with various chain lengths in neuroblastoma x glioma NG108-15 cell membranes.
Inhibition of binding of beta h-endorphin or Leu-enkephalin by beta h-endorphin analogs of various chain lengths in memmbrane preparations of the neuroblastoma x glioma NG108-15 cells has been investigated. The removal of even a single residue from the C-terminus results in the inability of the resulting peptide to completely displace beta h-endorphin. In addition, the proportion of nondisplaceable binding increases with decreasing chain length.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000378:metabolism; D005910:Glioma; D066298:In Vitro Techniques; D007700:Kinetics; D009447:Neuroblastoma; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism*; D013329:Structure-Activity Relationship; D001615:beta-Endorphin
D004723:Endorphins; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine; D001615:beta-Endorphin