[Influence of ranitidine on antipyrine metabolism (author's transl)].
Antipyrine kinetics were determined in 6 healthy volunteers before and after the end of a 1 week treatment period of ranitidine 150 mg twice a day. The mean antipyrine half-life (h) was before 12.6 +/- 4.6 h and after ranitidine treatment 12.0 +/- 2.6 h. Antipyrine clearance (ml/min) and volume of distribution (1) were not altered following ranitidine administration. The results suggest that ranitidine has no influence on antipyrine-metabolism in healthy volunteers.
D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D005260:Female; D005663:Furans / Q000494:pharmacology*; D006207:Half-Life; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011899:Ranitidine; D013997:Time Factors
D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D000983:Antipyrine
Untersuchungen zur Wirkung von Ranitidin auf den Antipyrin-Metabolismus.