[Hydrogenated and cyclohomologous derivatives of phenothiazine. Synthesis and pharmacological activity of various cycloalkyl derivatives of 4H-benzo(b)(1,4)thiazine].
The synthesis and the results of pharmacological screening of 4H-benzo[b][1,4]thiazine derivatives are described. These substances were prepared by reacting 2,2'-dithiodianiline with ethyl-2-oxocycloalkanecarboxylates followed by NaBH4 reduction. The pharmacological results indicate remarkable depressive activity [see (IV b) (n = 3)] shown by 100% potentiation of barbituric-induced sleeping time.
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D051379:Mice; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D014150:Antipsychotic Agents; D013843:Thiazines
Ricerche su derivati idrogenati e ciclomologhi della fenotiazina. Sintesi ed attivit farmacologica di alcuni derivati cicloalchilici della 4H-benzo[b][1,4]tiazina.