Progesterone and estrogens in rat brain: modulation of GABA (gamma-aminobutyric acid) receptor activity.
Our data indicate that estrogens and progesterone can regulate the number of GABA receptors (as detected by [3H]muscimol binding assay) in rat brain. Both hormones act in selected areas. The extent of the effect (up to 160% increase) and the number of areas responsive suggest that sex hormones may play a very important role in the regulation of the functions of GABAergic transmission in the central nervous system.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007555:Isoxazoles; D007700:Kinetics; D009118:Muscimol / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D004967:Estrogens; D007555:Isoxazoles; D009419:Nerve Tissue Proteins; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D009118:Muscimol; D011374:Progesterone; D005680:gamma-Aminobutyric Acid; C041650:isothaz