Vanadate and aqueous humor dynamics. Proctor Lecture.
Topical administration of 0.5% vanadate lowers intraocular pressure in monkey and rabbit eyes. This appears to be a consequence of a reduction in the rate of aqueous humor secretion, probably resulting from the inhibition of ciliary epithelium membrane. NaK ATPase. The ubiquitous vanadate and its interactions with catecholamines and ascorbate may play a role in regulating the sodium pump of the ciliary epithelium. Adrenergic blocking agents may also lower intraocular pressure by inhibiting the NaK ATPase of the ciliary epithelium.
D000319:Adrenergic beta-Antagonists; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects*; D001205:Ascorbic Acid / Q000502:physiology; D002395:Catecholamines / Q000502:physiology; D002924:Ciliary Body / Q000187:drug effects / Q000201:enzymology; D000882:Haplorhini; D006801:Humans; D066298:In Vitro Techniques; D007429:Intraocular Pressure / Q000187:drug effects*; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology; D014639:Vanadium / Q000494:pharmacology* / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D014639:Vanadium; D000254:Sodium-Potassium-Exchanging ATPase; D001205:Ascorbic Acid