title: Cyclic AMP, 5-HT, and the modulation of transmitter release at the crayfish neuromuscular junction.
abstract: In this study it was found that several agents which elevate cAMP levels in cells also increase dramatically the quantity of transmitter released from crayfish excitatory nerve terminals in response to a stimulus. With respect to time course and magnitude, the increase produced by one of these agents, the cyclic nucleotide phosphodiesterase inhibitor Squibb 20,009 (SQ 20,009), is unlike any reported for such a drug at a synapse. Additionally, SQ 20,009 potentiated the facilitation of transmitter release produced by serotonin (5-HT) at this synapse. These results establish a possible role for cAMP in the control and modulation of transmitter release at the crayfish neuromuscular junction (NMJ). They further suggest that 5-HT functions here by activation of a presynaptically located adenylate cyclase.
mesh_terms: D000818:Animals; D003400:Astacoidea; D000242:Cyclic AMP / Q000494:pharmacology* / Q000502:physiology; D004974:Etazolate / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D018377:Neurotransmitter Agents; D012701:Serotonin; D000242:Cyclic AMP; D004974:Etazolate