Effects of alcohol and flunitrazepam on mood and performance in healthy young men.
Alcohol and flunitrazepam did not have any pharmacokinetic interactions when ingested 30 minutes apart at night. Flunitrazepam, 2.0 mg, but not 0.8 Gm/kg alcohol had a strong deleterious effect on performance shortly after ingestion. The combination of flunitrazepam and alcohol impaired tracking in a divided attention task the following morning.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001944:Breath Tests; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D005445:Flunitrazepam / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D013647:Task Performance and Analysis
D014151:Anti-Anxiety Agents; D000431:Ethanol; D005445:Flunitrazepam