[Serum lipid levels under chronical treatment with beta-receptor blocking agents in patients with coronary artery disease (author's transl)].
Concerning the effects of beta-receptor blocking agents (beta-RB) on serum lipids levels of total cholesterol, HDL cholesterol and triglycerides were determined in 237 consecutive male patients with coronarographically proven coronary artery disease. 43% (n = 101) of all patients were taking beta-RB. The percentage of factors apt to influence serum lipid levels and the extent of coronary artery disease were similar in the subsets with (group 1) and without (group 2) chronical beta-RB therapy.-The mean values of total cholesterol (group 1: 242 mg%, group 2: 239 mg%) and HDL cholesterol (group 1: 42 mg%, group 2: 41 mg%) were nearly identical; there were, however, significantly enhanced triglyceride concentration under beta-RB therapy (group 1: 222 mg%, group 2: 184 mg%, p less than 0.0125). This difference was most pronounced in patients with one-vessel disease. Patients treated with beta-1-selective RB had lower triglyceride levels than those treated with nonselective RB (208 mg% vs. 222 mg%, n.s.). In accordance with findings of other authors, these data might indicate that serum triglycerides are elevated by chronical administration of beta-RB. It should be a topic of further investigations if the present results can be interpreted the way that chronical application of beta-RB might favour development and/or deterioration of coronary artery disease.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000428:Alcohol Drinking; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D003920:Diabetes Mellitus / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D008875:Middle Aged; D010869:Pindolol / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D012907:Smoking; D014280:Triglycerides / Q000097:blood
D000319:Adrenergic beta-Antagonists; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol; D011433:Propranolol; D010869:Pindolol; D008790:Metoprolol
Serumlipide unter chronischer Behandlung mit beta-Rezeptroenblockern bei Patienten mit koronarer Herzkrankheit.