Single-dose antimicrobial prophylaxis in open heart surgery.
A single one-gram pre-operative dose of ceftriaxone was compared with seven one-gram doses of cefazolin administered peri-operatively with the aim of preventing infections associated with coronary artery bypass graft surgery. Ninety-four evaluable cases were analyzed; 49 patients received ceftriaxone and 45 received cefazolin. There was no significant difference in the number of infectious complications between the two groups. Ceftriaxone had a terminal half-life of approximately 15.7 hours. There was no toxicity associated with either antibiotic. Because of the reduced number of doses, single-dose prophylaxis may result in considerable savings. Single-dose prophylaxis with ceftriaxone was found to be an effective modality for prevention of infection in open heart surgery.
D001424:Bacterial Infections / Q000517:prevention & control; D002437:Cefazolin / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D002439:Cefotaxime / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D002443:Ceftriaxone; D001026:Coronary Artery Bypass; D003365:Costs and Cost Analysis; D004311:Double-Blind Method; D006801:Humans; D007700:Kinetics; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control
D002443:Ceftriaxone; D002437:Cefazolin; D002439:Cefotaxime