Purine receptors in trachea: studies with adenosine deaminase and dipyridamole.
ATP, adenosine, adenine and inosine exhibited similar potency in relaxing transverse strips of guinea-pig trachea. Dipyridamole potentiated responses to ATP and adenosine equally but antagonized responses to inosine and failed to affect responses to adenine. In dipyridamole-treated preparations, adenosine deaminase markedly reduced responses to ATP and adenosine; responses to adenine and inosine were unaffected. The results suggest that ATP acts via its adenosine metabolite and that inhibitory ATP receptors are absent.
D000241:Adenosine / Q000494:pharmacology; D000243:Adenosine Deaminase / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D004176:Dipyridamole / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007288:Inosine / Q000494:pharmacology; D008297:Male; D009130:Muscle, Smooth / Q000378:metabolism*; D009700:Nucleoside Deaminases / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011983:Receptors, Purinergic; D014132:Trachea / Q000378:metabolism
D017981:Receptors, Neurotransmitter; D011983:Receptors, Purinergic; D007288:Inosine; D004176:Dipyridamole; D000255:Adenosine Triphosphate; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D000241:Adenosine