Failure to demonstrate mu-isoreceptors.
Attempts have been made to confirm reports that naloxonazine and Mr2034 are able to selectively antagonise morphine-induced analgesia and respiratory depression respectively. In the present studies these antagonists proved to be equi-effective against both the analgesic and respiratory depressant effects of morphine, suggesting that these two actions are mediated by a common receptor.
D000818:Animals; D001575:Benzomorphans / Q000494:pharmacology; D005260:Female; D051379:Mice; D009270:Naloxone / Q000031:analogs & derivatives / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D017450:Receptors, Opioid, mu; D012119:Respiration / Q000187:drug effects
D001575:Benzomorphans; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D009270:Naloxone; C032478:MR 2034; C034643:naloxonazine