Response of protein C and protein C inhibitor to warfarin therapy in patient with combined deficiency of Factors V and VIII.
The role of Protein C in combined factor V/VIII deficiency was examined by reducing the Protein C concentration using warfarin therapy in a patient with the combined deficiency. The factor VIII deficiency was like Hemophilia-A, with deficiency of VIII:C and VIII:C(Ag), but normal VIIIR:Ag and VIIIR:cof. The factor V deficiency was due to loss of the V antigen. During warfarin therapy the Protein C level was reduced, but concentrations of factors V and VIII did not change. Protein C Inhibitor was normal throughout. Thus combined factor V/VIII deficiency is not related to Protein C levels.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D005166:Factor V Deficiency / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D011486:Protein C; D018046:Protein C Inhibitor; D014859:Warfarin / Q000627:therapeutic use*
D001798:Blood Proteins; D006023:Glycoproteins; D011486:Protein C; D018046:Protein C Inhibitor; D014859:Warfarin