title: Participation of the beta-adrenergic receptor in the enteroruminal reflex and enteroenteric reflex.
abstract: In sheep with chronic fistulae of the small intestine and rumen the participation of the beta-adrenergic receptor was investigated in the enteroruminal reflex and enteroenteric reflex using the method of pharmacological analysis. The movements of the segments of the digestive tract with fistulae were recorded by the balloon method. A solution of hydrochloric acid administered into the ileum caused a reflex stimulation of its motor activity and inhibited the movements of the rumen. Intravenous administration of propranolol before instillation of the acid into the intestine abolished or reduced greatly the reflex inhibition of the movements of the rumen and in the small intestine it enhanced significantly the studied reflex reaction. Thus stimulation of the beta-adrenergic receptor plays an important role in the reflex stimulation of the motor activity of the rumen, and stimulation of the motor activity of the small intestine in the enteroenteric reflex is limited by the effects derived from this receptor.
mesh_terms: D000818:Animals; D005769:Gastrointestinal Motility / Q000187:drug effects; D006851:Hydrochloric Acid / Q000494:pharmacology; D007082:Ileum; D007263:Infusions, Parenteral; D007267:Injections; D007422:Intestines / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D012417:Rumen / Q000187:drug effects / Q000502:physiology*; D012756:Sheep
chemical_list: D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D007545:Isoproterenol; D006851:Hydrochloric Acid