[The effect of some beta-blocking drugs on plasma renin activity, platelet adhesiveness and dilute blood clot lysis time in patients with essential arterial hypertension].
Propranolol (160--240 mg/24 h) and Oxprenolol (80--240 mg/24 h) were given for different periods of time to 13 and, respectively, 7 patients with essential arterial hypertension stage II. Both these beta-blocking drugs induced a significant fall in plasma renin activity : after ten days of treatment, platelet adhesiveness decreased in the patients with a basal level over 50% and increased in those with basal level below 30% (p < 0.01). When this treatment was given for 30 consecutive days, platelet adhesiveness decreased even in the latter patients. The drugs were also found to accelerate dilute blood clot lysis time in patients who presented a delayed lysis time before therapy. Thus, it is inferred that both propranolol and oxprenolol eliminate, at least partly, several factors involved in the pathogenesis of atherosclerosis, a frequent complication of essential arterial hypertension.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008875:Middle Aged; D010096:Oxprenolol / Q000627:therapeutic use; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011433:Propranolol / Q000627:therapeutic use; D012083:Renin / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D010096:Oxprenolol; D011433:Propranolol; D012083:Renin