title: A saturable binding site for high density lipoprotein3 on human liver membranes.
abstract: The binding of High Density Lipoprotein3 (HDL) to human liver membranes obtained from male normolipemic subjects was studied. High Density Lipoprotein3 binds in a specific, saturable manner to liver membranes; furthermore, this binding site appears to be distinct from these previously described for Low Density Lipoprotein (LDL) and chylomicron remnants. Competition experiments using Apo A-I reconstituted lipoproteins suggest that Apo A-I could be the determinant of the binding.
mesh_terms: D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000378:metabolism; D001665:Binding Sites; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007700:Kinetics; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008297:Male; D008566:Membranes / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D007457:Iodine Radioisotopes; D008055:Lipids; D008075:Lipoproteins, HDL; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D011956:Receptors, Cell Surface