Humoral factors involved in the regulation of sodium-fluid balance in normal man. II. Effect of indomethacin on sodium concentration, renal prostaglandins, vasopressin and renin-angiotensin-aldosterone system.
The effect of drastic sodium chloride changes (performed by using low-Na diet + furanthril and high-Na diet) on renin-angiotensin-aldosterone system, vasopressin and renal prostaglandins was studied in normal subjects after inhibition of prostaglandin synthesis by indomethacin (0.35 mg/kg three times daily for 13 days). The purpose of the investigation was to evaluate the mechanism of prostaglandin-vasopressin interrelationship. Indomethacin inhibition of PG-synthesis was performed, and after high-Na provocation, an increase of vasopressin and cyclic AMP excretion by 15% and 376% more than that without indomethacin was found. Indomethacin by itself caused sodium retention and antidiuretic effect. The results confirmed the assumption that renal prostaglandins are modulators of renin release from the kidney and that they alternate vasopressin effect on urine concentration, most probably through adenylate cyclase-cAMP system.
D000328:Adult; D000450:Aldosterone / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011453:Prostaglandins / Q000378:metabolism* / Q000502:physiology; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012964:Sodium / Q000378:metabolism*; D014667:Vasopressins / Q000378:metabolism* / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000187:drug effects
D011453:Prostaglandins; D014667:Vasopressins; D000450:Aldosterone; D012964:Sodium; D000242:Cyclic AMP; D007213:Indomethacin