The efficacy and safety of enalapril in moderate to severe essential hypertension.
When added to hydrochlorothiazide, enalapril is as effective as captopril in the treatment of moderate to severe hypertension. It is also effective when used as monotherapy, and may be incorporated into a regimen with diuretic and methyldopa or timolol for the treatment of more resistant patients. Enalapril has a good safety profile as measured by frequency of clinical and laboratory adverse experiences.
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D008875:Middle Aged; D011897:Random Allocation; D013223:Statistics as Topic
D000806:Angiotensin-Converting Enzyme Inhibitors; D006852:Hydrochlorothiazide; D008750:Methyldopa; D004656:Enalapril; D002216:Captopril