title: Catecholamine control of enzymes involved in isocitrate oxidation of rat liver mitochondria.
abstract: Treatment of rats or liver homogenates with catecholamines (isoproterenol or noradrenaline) increased activities of both NAD+ -dependent isocitrate dehydrogenase and NAD(P)+-transhydrogenase (in the direction of hydrogen transfer NADPH----NAD+) with no change in NADP+ -dependent isocitrate dehydrogenase. These effects were realized via beta-adrenoceptors. Cyclic AMP mimicked the catecholamine action on incubation with liver homogenate. The effects of catecholamines and cyclic AMP were not additive.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D007523:Isocitrates / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009250:NADP Transhydrogenases / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007523:Isocitrates; C034219:isocitric acid; D011433:Propranolol; D000242:Cyclic AMP; D007521:Isocitrate Dehydrogenase; D009250:NADP Transhydrogenases; D007545:Isoproterenol; D009638:Norepinephrine; D010646:Phentolamine