Biological activities of isomers of 8,15-dihydroxyeicosatetraenoic acid.
Chemically synthesized 8(S), 15(S)-dihydroxy-5,11-cis-9, 13-trans-eicosatetraenoic acid and 8(R), 15(S)-dihydroxy-5,11-cis-9,13-trans-eicosatetraenoic acid were inactive, in comparison to leukotriene B4, in a human polymorphonuclear leukocyte chemokinetic assay and a rat polymorphonuclear leukocyte aggregation assay.
D000818:Animals; D002449:Cell Aggregation / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D007975:Leukotriene B4 / Q000031:analogs & derivatives* / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007975:Leukotriene B4; C030722:8,15-leukotriene B4