[Ultrastructural characteristics of bone marrow subendosteal region cells in T-cell virus-induced leukemia].
The experiments were carried out to study hemopoietic and stromal cells of bone marrow subendosteal regions during T-cell lymphomagenesis in AKR mice, using transmission electron microscopy and electron microscopic immunocytochemistry methods. It is shown that the subendosteal region of mice with lympholeukosis is replaced by lymphocytes at different stages of differentiation with certain ultrastructural peculiarities. The association of alkaline-phosphatase positive reticulum cells with granulocytes is destroyed. The alkaline phosphatase activity in reticulum cells of the subendosteal region of mice with spontaneous lympholeukosis is very low or absent. The results obtained may be useful for understanding the AKR lymphomagenesis.
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure*; D006412:Hematopoietic Stem Cells / Q000648:ultrastructure; D007942:Leukemia, Experimental / Q000209:etiology / Q000473:pathology*; D051379:Mice; D008806:Mice, Inbred AKR; D008854:Microscopy, Electron; D012190:Retroviridae; D012192:Retroviridae Infections / Q000473:pathology*; D013601:T-Lymphocytes / Q000648:ultrastructure
Ul'trastrukturnye osobennosti kletok subéndostal'noĭ oblasti kostnogo mozga pri T-kletochnom virusindutsirovannom leĭkoze.