Insulin effect in vitro on human erythrocyte plasma membrane.
The effect of porcine insulin has been tested in vitro on human erythrocyte plasma membrane (Na+-K+) and Mg2+-ATPase activities as well as on membrane fluidity. The results indicate that the hormonal treatment significantly inhibits (Na+-K+)-ATPase activity, and at the same time decreases membrane fluidity.
D000251:Adenosine Triphosphatases / Q000097:blood*; D017301:Ca(2+) Mg(2+)-ATPase; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008560:Membrane Fluidity / Q000187:drug effects; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000097:blood
D007328:Insulin; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase