title: Inter-relationships between sodium and potassium intake and the blood pressure effects of ACTH in sheep.
abstract: These studies examine the effect of sodium (Na) and potassium (K) intake on the pressor and metabolic actions of ACTH (20 micrograms/kg/day) in sheep. After 21 days on each of five regimens in which Na and K intake varied from 0 to 100 mmol/day, no simple relationship between Na and K intake and blood pressure was found. After five days of ACTH treatment, mean arterial pressure (MAP) rose + 5 mmHg in sheep on 0 mmol Na, 0 mmol K (expressed as 0 Na 0 K); + 13 mmHg on 10 Na 100 K; + 5 mmHg on 0 Na 100 K; + 20 mmHg on 100 Na 0 K and + 24 mmHg on 100 Na 100 K. Plasma [K] was unchanged by ACTH on 0 Na 0 K but fell in sheep on the other electrolyte regimens. Water intake increased with ACTH on all regimens except 100 Na 0 K. Blood aldosterone concentration was high in sheep maintained on 0 Na regimens but lower after five days of ACTH treatment in all groups. Blood cortisol and corticosterone concentrations increased with ACTH on all regimens studied.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001834:Body Water / Q000378:metabolism; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced; D011188:Potassium / Q000008:administration & dosage* / Q000378:metabolism; D012756:Sheep; D012964:Sodium / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D000324:Adrenocorticotropic Hormone; D012964:Sodium; D011188:Potassium