title: Amoebicidal activity of the antifungal antibiotic sinefungin against Entamoeba histolytica.
abstract: The antifungal antibiotic sinefungin, a potent inhibitor of methyl transferases and a potential inhibitor of polyamine biosynthesis, exhibited marked cytolytic activity against Entamoeba histolytica in vitro with respect to all the amoeba strains tested. Strains of high and low virulence displayed equal sensitivity to the antibiotic. Minimal Amoebicidal Concentration was 5 to 10 micrograms/ml.
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000563:Amebicides; D000818:Animals; D000935:Antifungal Agents; D004748:Entamoeba histolytica / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D000563:Amebicides; D000935:Antifungal Agents; D000241:Adenosine; C006235:sinefungin