Efficacy of some drugs on Leishmania donovani in the golden hamster, Mesocricetus auratus.
The therapeutic and prophylactic effect of dehydroemetine and pentostam on Leishmania donovani in experimentally infected golden hamsters (Mesocricetus auratus) have been investigated. The intracardially infected hamsters with L. donovani and treated with dehydroemetine showed significantly lower weights in liver and spleen, and less in spleen length than those treated with pentostam. Dehydroemetine and pentostam failed to provide these animals with any protection against experimental infection with L. donovani when the drugs were administered prophylactically.
D000818:Animals; D000967:Antimony Sodium Gluconate / Q000009:adverse effects / Q000627:therapeutic use*; D006224:Cricetinae; D004640:Emetine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005942:Gluconates / Q000627:therapeutic use*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000517:prevention & control; D007928:Lethal Dose 50; D008297:Male; D008647:Mesocricetus
D005942:Gluconates; D000967:Antimony Sodium Gluconate; D004640:Emetine