title: Relationships between chromosomal patterns and protooncogenes in human benign salivary gland tumors.
abstract: By banding methods the chromosomes were studied in 20 cultured benign mixed salivary gland tumors. The results were considered together with the findings in 61 previously studied adenomas. About 55% of the 81 adenomas had a normal stemline. A total of 39 abnormal stemlines were found in the remaining 36 cases. The abnormal stemlines could be divided into four groups: 1) A large group with chromosome 8 involvement, mostly translocations of segments distal to 8q12; 2) A small group with chromosome 12 involvement, usually translocations of segments distal to 12q13-15;3) A small group with translocations and/or deletions affecting a distal segment of either the short or the long arm of chromosome 3; 4) A heterogeneous and small group with deviations related to those seen in variant cells in cases with normal stemlines. Comparisons with the known localization of proto-oncogenes revealed that almost 60% of the abnormal stemlines showed anomalies which could fit with oncogene activation. Future mapping studies of proto-oncogenes, as well as studies of combined actions of proto-oncogenes, different viral genes and some poorly understood oncogenic factors, will no doubt, enable a more complete characterization of the roles played by oncogenes in the genesis and progression of mixed tumors.
mesh_terms: D008949:Adenoma, Pleomorphic / Q000235:genetics*; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D010307:Parotid Neoplasms / Q000235:genetics*; D012468:Salivary Gland Neoplasms / Q000235:genetics; D013363:Submandibular Gland; D014178:Translocation, Genetic