Effect of inhibitors of catecholamine synthesis on the pituitary response to LH-RH.
Cathecolamines have an important role in the regulation of LH secretion. The effect of two selective blocking drugs of cathecolamines synthesis upon pituitary response to LH-RH was studies. Basal levels of serum LH in rats treated with alpha-methyl-p-tyrosine and diethyldithiocarbamate were significantly lower than those of control rats. Diethyldithiocarbamate induced a greater decrease of LH levels than alpha-methyl-p-tyrosine. The rats treated with diethyldithiocarbamate showed an LH increase after LH-RH stimulation that was significantly higher as compared with control group as well as in alpha-methyl-p-tyrosine treated group.
D000818:Animals; D002369:Castration; D004050:Ditiocarb / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013859:Thiocarbamates / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors*; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D013859:Thiocarbamates; D007987:Gonadotropin-Releasing Hormone; D019805:alpha-Methyltyrosine; D007986:Luteinizing Hormone; D004050:Ditiocarb; D014446:Tyrosine 3-Monooxygenase