[Electroencephalographically determined sedative effects (vigilosomnography) of the new Thienodiazepin-derivate clotiazepam (author's transl)].
In a double blind, randomized clinical study eighteen volunteers received either placebo or 5 mg diazepam or 5 mg clotiazepam at three different times at an interval of one week. Beside other parameters which have been measured a 60-minute polygraphic EEG recording was made thirty minutes after administration of the drugs. The vigilosomnograms revealed clear and reliable differences between placebo and the two active substances and suggest a sedative effect of both substances at the dose level used. There was only a slight difference between the two active substances. 5 mg clotiazepam produced a slightly stronger sedation than 5 mg diazepam. However, the records of autonomic side effects and subjective statements regarding the patients' condition showed that clotiazepam is associated with less side effects than diazepam.
D000328:Adult; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects; D001381:Azepines / Q000009:adverse effects*; D003975:Diazepam / Q000009:adverse effects; D004311:Double-Blind Method; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008297:Male; D012894:Sleep Stages / Q000187:drug effects*
D001381:Azepines; D003975:Diazepam
Die elektroenzephalographisch bestimmte sedierende Wirkung (Vigilosomnographie) des neuen Thienodiazepin-Derivates Clotiazepam (Trecalmo).