title: [State of the adrenergic and cholinergic systems of schizophrenic patients during the process of psychopharmacotherapy].
abstract: The state of catecholamine and acetylcholine metabolism in schizophrenic patients with recurrent, attacklike-progressive and continuous forms was studied during the process of neuroleptical treatment. The level of doses, duration of administration and the dynamics of the mental state were taken into consideration. It was established that in schizophrenic patients the correlation of the studied system compared to the control group is changed. The study demonstrated different types of changes in catecholamine metabolism in patients with different forms of the schizophrenic process, prior to and during psychopharmacotherapy. The obtained results permitted to give some recommendations in the therapeutic approaches in schizophrenic patients with attack-like and continuous forms of the disease.
mesh_terms: D000109:Acetylcholine / Q000097:blood / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000097:blood; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002395:Catecholamines / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000652:urine; D004298:Dopamine / Q000652:urine; D004837:Epinephrine / Q000032:analysis; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D008875:Middle Aged; D009638:Norepinephrine / Q000032:analysis; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism; D013577:Syndrome; D014642:Vanilmandelic Acid / Q000652:urine
chemical_list: D014150:Antipsychotic Agents; D002395:Catecholamines; D014642:Vanilmandelic Acid; D004295:Dihydroxyphenylalanine; D000110:Acetylcholinesterase; D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine
vernacular_title: Sostoianie adrenergicheskoĭ i kholinergicheskoĭ sistem u bol'nykh shizofrenieĭ v protsesse psikhofarmakoterapii.