Reduction of dopaminergic supersensitivity by a single dose of amphetamine.
Chronic administration of haloperidol in rats resulted in a supersensitivity to apomorphine-induced stereotypy. This behavioral supersensitivity was reduced by a single administration of d-amphetamine given 2 days after the termination of haloperidol injections. The reduction of haloperidol-induced supersensitivity by amphetamine lasted for at least 3 days after amphetamine injection.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects
D014150:Antipsychotic Agents; D006220:Haloperidol; D003913:Dextroamphetamine; D004298:Dopamine