Pathogenesis of osteopetrosis induced by rapid and slow onset plaque isolates of an avian osteopetrosis virus.
Examination of bone from chickens infected as 10-day-old embryos with isolates of an avian osteopetrosis virus revealed that MAV-2(O) plaque isolate 32/2/4 caused rapid bone growth, while MAV-2(O) plaque isolate 13 caused a mild form of bone growth. MAV-2(O) plaque isolate 32/2/4 caused anemia when injected into the 8-day-old hatched chick and bone growth in ovo when injected into the 4-day-old embryo. Passive administration of neutralizing antibody protected against MAV-2(O)-induced bone growth when antibody was given to the embryo 1 day after virus. Neutralizing antibody also protected against an acute anemia observed when normal and bursectomized chickens were given MAV-2(O) 32/2/4, but antibody did not prevent the appearance of a chronic anemia or osteopetrosis in bursectomized chickens. Repeated animal passage of a slow onset plaque isolate of MAV-2(O) caused the virus to progressively induce more severe bone growth and anemia.
D000740:Anemia / Q000209:etiology; D000818:Animals; D001353:Avian Leukosis; D001354:Avian Leukosis Virus / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology*; D002060:Bursa of Fabricius / Q000502:physiology; D002642:Chick Embryo; D002645:Chickens; D007116:Immunization, Passive; D010022:Osteopetrosis / Q000209:etiology / Q000473:pathology*; D013997:Time Factors