Angiotensin II receptors in the brain and adrenal glands of rats with experimental and spontaneous hypertension.
Angiotensin II receptors in the brain and adrenal glands of rats with experimental and spontaneous hypertension were studied. The data have shown that the capacity of binding sites does not change substantially in the adrenal gland while in the brain of spontaneous hypertensive rats it is lower and increases in those with experimental hypertension. There is also a change in the affinity of binding in both the adrenal gland and the brain of the spontaneously hypertensive rats. The data suggest some changes in tissue sensitivity to hormone in the spontaneously hypertensive rats.
D000311:Adrenal Glands / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry; D006973:Hypertension / Q000378:metabolism*; D006977:Hypertension, Renal / Q000209:etiology / Q000378:metabolism; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007700:Kinetics; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D011945:Receptors, Angiotensin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D007457:Iodine Radioisotopes; D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D000804:Angiotensin II