title: Ion transport, prostaglandins, and essential hypertension.
abstract: Prostaglandins (including PGE1, PGE2 and PGI2) showed little or no effect on Na+ and K+ transport across human red cell membranes. Conversely, they were able to: i) inhibit Na+, K+ cotransport system, ii) stimulate Na+, K+-pump and iii) stimulate Na+, Ca2+ exchange in mouse macrophages. These effects which seem to be mediated by cyclic AMP, provoke a more rapid extrusion of a cell Na+ -load. This may counterbalance the abnormal cell Na+ regulation that appears to be associated with essential hypertension.
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007213:Indomethacin / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D011188:Potassium / Q000378:metabolism; D011453:Prostaglandins / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D002118:Calcium; D007213:Indomethacin