title: Principles and pitfalls of nerve conduction studies.
abstract: This report reviews the fundamental principles and the changing concepts of nerve stimulation techniques, and discusses the proper application of these techniques in the differential diagnosis of peripheral nerve disorders. Nerve conduction studies help delineate the extent and distribution of the neural lesion and distinguish two major categories of peripheral nerve disease: demyelination and axonal degeneration. Although the method is based on simple principles, pitfalls abound in practice. Variability in nerve conduction measurement may result from temperature change, variations among nerve segments, and the effects of age. Other sources of error include excessive spread of stimulation current, anomalous innervation, temporal dispersion, and inaccuracy of surface measurement. Unlike a bipolar derivation, which selectively records near-field potentials, a referential recording may give rise to stationary far-field peaks from a moving source. Overlooking this possibility can lead to an incorrect interpretation of findings. Conventional nerve conduction studies deal primarily with measurements of the distal nerve segments in an extremity. More recent techniques are applicable to less accessible anatomical regions, as illustrated by elicitation of the blink reflex, F wave, and H reflex, and the use of the inching technique. Other methods used to assess special aspects of nerve conduction include the ischemic test and studies of slow-conducting fibers.
mesh_terms: D001369:Axons / Q000502:physiology; D001767:Blinking; D003711:Demyelinating Diseases / Q000175:diagnosis; D004558:Electric Stimulation; D005071:Evoked Potentials; D006181:H-Reflex; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D009408:Nerve Compression Syndromes / Q000175:diagnosis; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D012677:Sensation / Q000502:physiology; D009435:Synaptic Transmission