[In vitro properties of various growth factors and in vivo effects].
This article summarizes some of the data that have been accumulated on several growth factors. Biochemical and biological properties of the Epidermal, Fibroblast, Astrocytes and Tumor growth factors (EGF, FGF, AGF, TGF) and those of growth factors derived from Platelets (PDGF), Brain (BDGF, ECGF), Eye (EDGF) and Cartilage (CDGF) are reviewed, as well as the in vitro mechanism of action of EGF and PDGF. The in vivo effects of these growth factors, particularly the experiments achieved to understand the physiological or physiopathological significance are described. The potential interest of these molecules in pharmacology and their use as wound healing agents is discussed.
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor; D002453:Cell Cycle / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006133:Growth Substances / Q000302:isolation & purification / Q000494:pharmacology* / Q000502:physiology; D009928:Organ Specificity; D010455:Peptides / Q000494:pharmacology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000502:physiology; D015291:Transforming Growth Factors
D019208:Brain-Derived Neurotrophic Factor; D006133:Growth Substances; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D011506:Proteins; D011956:Receptors, Cell Surface; C019277:brain-derived growth factor; C039825:eye-derived growth factor; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors
Propriétés in vitro de quelques facteurs de croissance et effets in vivo.