Differential effects of cyclic AMP on DNA synthesis by germ cells and non-germ cells in mouse testicular culture.
The effect of dibutyryl cyclic AMP (dbcAMP) on DNA synthesis in mouse cryptorchid explants with only type A spermatogonia was examined in vitro. Low concentration of dbcAMP (0.08 mmol/l) stimulated DNA synthesis by germ cells but inhibited that by non-germ cells.
D000818:Animals; D001345:Autoradiography; D003994:Bucladesine / Q000494:pharmacology*; D003456:Cryptorchidism / Q000378:metabolism; D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology
D003994:Bucladesine; D004247:DNA; D013806:Theophylline