Cross-species extrapolation in hydrocarbon neuropathy.
Not all species demonstrate the same vulnerability to hydrocarbon neuropathy. These differences are related to axonal length and diameter as well as to variations in toxicokinetics. While cross-species extrapolation is made difficult by these factors, understanding the basis for the differences provides insight into pathogenesis.
D000818:Animals; D001369:Axons; D002645:Chickens; D003599:Cytoskeleton / Q000187:drug effects; D004198:Disease Susceptibility; D006586:Hexanes / Q000633:toxicity; D006588:Hexanones / Q000633:toxicity; D006801:Humans; D006838:Hydrocarbons / Q000633:toxicity*; D051379:Mice; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D051381:Rats; D013045:Species Specificity
D006586:Hexanes; D006588:Hexanones; D006838:Hydrocarbons; C039195:3,4-dimethyl-2,5-hexanedione; C026385:n-hexane; C011269:2,5-hexanedione