Methylphenidate-like stimulants in vitro release [3H]tyramines but not [14C]dopamine.
The effects of methylphenidate, cocaine, nomifensine and amfonelic acid on the simultaneous uptake and release of [14C]dopamine and [3H]p-tyramine or [3H]m-tyramine were examined in rat striatal slices. While the uptake of each amine was inhibited equally by each drug, only [3H]tyramines were released. The d-amphetamine-induced release of [14C]dopamine and [3H]p-tyramine was antagonized by these drugs. These findings suggest that the tyramines can be transported independently from dopamine.
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D051381:Rats; D014439:Tyramine / Q000378:metabolism*
D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D003913:Dextroamphetamine; D004298:Dopamine; D014439:Tyramine