title: The stability of trifluorothymidine: hydrolysis in buffered aqueous solutions.
abstract: The decomposition of trifluorothymidine in aqueous solution, and borate and phosphate buffers has been studied using an h.p.l.c. method. In aqueous solution accelerated studies demonstrate that a storage life, to 10% loss, of more than 30 years at 4 degrees C is predicted, but steam sterilization causes extensive breakdown. Considerable differences occur in the kinetics and routes of decomposition in borate and phosphate buffers in the pH range 4-8. Hydroxide ion attack producing 5-carboxy-2'-deoxyuridine is suppressed in borate buffers. Complex kinetics of decomposition in phosphate buffer are found and possible explanations suggested. Steam sterilization in buffered solution also leads to unacceptable breakdown.
mesh_terms: D001881:Borates; D002021:Buffers; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D010710:Phosphates; D012996:Solutions; D013936:Thymidine / Q000031:analogs & derivatives; D014271:Trifluridine
chemical_list: D001881:Borates; D002021:Buffers; D010710:Phosphates; D012996:Solutions; D014271:Trifluridine; D013936:Thymidine