Cellular biology of the renin-angiotensin systems.
The renin-angiotensin system is a major determinant of arterial pressure and intravascular volume in human beings. Recent evidence, however, suggests that renin can be synthesized at local tissue sites and that these local renin-angiotensin systems subserve important physiologic functions. In addition, it appears that there exist intracellular renin-angiotensin "systems" capable of generating angiotensin II intracellularly.
D000804:Angiotensin II / Q000378:metabolism; D000805:Angiotensin III / Q000378:metabolism; D000818:Animals; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology; D012083:Renin / Q000096:biosynthesis / Q000502:physiology; D012084:Renin-Angiotensin System; D014018:Tissue Distribution
D011956:Receptors, Cell Surface; D000804:Angiotensin II; D000805:Angiotensin III; D012083:Renin