title: Relationship of intracerebral pituitary grafts to central neuropeptide systems.
abstract: Variable amounts of pituitary tissue from neonatal or 30-day-old donor rats were implanted in the recessus triangularis or third ventricle of hypophysectomized male host rats. The pituitary tissue was implanted either immediately or 30 days after hypophysectomy of the host rat. Grafts from donors of either age were capable of maintaining a significant degree of testicular weight in one-third of the implanted animals. Neonatal grafts were not capable of restoring testicular weight when implanted 30 days after hypophysectomy. Final body weights of all graft-bearing animals were greater than those of hypophysectomized controls. The pars distalis of all grafts contained large numbers of cells immunore-active for LH, GH, and ACTH; TSH-immunoreactive cells were sparse. Prolactin-positive cells were extensive in grafts of animals in which the testes were maintained, and virtually absent in grafts of animals with atrophic testes. The fiber systems of three central neuropeptides, LRF, SRIF, and ACTH, were stained and found not to enter the graft. The results suggest that pituitary grafts in the third ventricle may receive their hypophysiotropic neuropeptides from the CSF.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000276:immunology; D000818:Animals; D001921:Brain / Q000601:surgery*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006651:Histocytochemistry; D007016:Hypophysectomy; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D009929:Organ Size; D010902:Pituitary Gland / Q000276:immunology / Q000378:metabolism / Q000637:transplantation*; D010907:Pituitary Hormones / Q000378:metabolism*; D051381:Rats; D013004:Somatostatin / Q000378:metabolism; D013737:Testis / Q000033:anatomy & histology; D014184:Transplantation, Homologous
chemical_list: D010907:Pituitary Hormones; D007987:Gonadotropin-Releasing Hormone; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones