title: Cefmenoxime: in vitro activity.
abstract: The in vitro activity of cefmenoxime (SCE-1365 or A-50912), a new semisynthetic cephalosporin antibiotic, was determined for a broad spectrum of 1,234 organisms isolated as part of a multiclinic study. The minimum inhibitory concentration (MIC) of cefmenoxime required to inhibit at least 90 percent of strains tested (MIC90) ranged from 0.12 to 8 micrograms/ml for Enterobacteriaceae. MIC90S were 0.015 and 0.06 microgram/ml for Streptococcus pneumoniae and S. pyogenes, respectively, and 4 micrograms/ml for Staphylococcus aureus. Group D streptococci were less susceptible. The MIC90 of cefmenoxime for Neisseria gonorrhoeae and Hemophilus influenzae was 0.06 microgram/ml. Cefmenoxime was less active against Pseudomonas aeruginosa, Acinetobacter species, and Bacteroides fragilis (MIC50 = 16 micrograms/ml).
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: D015281:Cefmenoxime; D002439:Cefotaxime