Venous complications after i.v. administration of Diazemuls (diazepam) and Dormicum (midazolam).
Local venous reactions during and after the injection i.v. of diazepam in oil (Diazemuls) and the water-soluble benzodiazepine midazolam (Dormicum) were studied in 100 patients undergoing gastroscopy. Observation time was 2 weeks. Of the patients receiving diazepam in oil, 8% experienced pain on injection and 6% subsequently developed clinical evidence of thrombophlebitis. Corresponding figures for midazolam were 6% and 10% respectively. No significant differences were observed between the effects of the two drugs.
D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects*; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D013924:Thrombophlebitis / Q000139:chemically induced*
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003975:Diazepam; D008874:Midazolam