Concentration and secretion of gastric somatostatin in streptozotocin-diabetic rats.
Both the release and the content of gastric somatostatin were investigated in streptozotocin-diabetic rats. Fundic and antral somatostatin contents were both increased in streptozotocin-diabetic rats compared with control animals. Basal somatostatin levels in the perfusates of streptozotocin-treated animals were not significantly different from those of the control animals. However, the peak values of somatostatin release induced by 5 x 10(-9) M glucagon in the diabetic animals were significantly higher than those of the controls. These results lead us to conclude that a hyperfunctioning state of the gastric D-Cells exists in hypoinsulinemic diabetes.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000378:metabolism*; D013311:Streptozocin
D001786:Blood Glucose; D007328:Insulin; D013004:Somatostatin; D013311:Streptozocin; D005934:Glucagon