The effect of phenobarbital on chlorphentermine-induced lipidosis-like alterations in renal tissue of adult and newborn rats.
Daily oral administration of 20 or 60 mg/kg chlorphentermine for 1 week produced a dose-related increase in the number of myeloid bodies in renal tissue of both adult and newborn rats. In adults myeloid bodies were present throughout the kidney while in neonates these bodies were found predominantly in the medullary region. Simultaneous administration of phenobarbital and either chlorphentermine dose resulted in a reduction in the number of myeloid bodies in kidneys of adults and newborns. Our data show that phenobarbital prevented the chlorphentermine-induced lipidosis in renal tissue and that newborns appear less sensitive than adults to the histopathologic action of anorectic on kidney.
D000818:Animals; D000831:Animals, Newborn; D002745:Chlorphentermine / Q000494:pharmacology; D004347:Drug Interactions; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology*; D008064:Lipidoses / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D002745:Chlorphentermine; D010634:Phenobarbital