title: Secretion of gamma-interferon at the cellular level. Induction by Epstein-Barr virus.
abstract: Using a haemolytic plaque assay for gamma-interferon (IFN-gamma) secretion we found that in vitro Epstein-Barr virus (EBV) exposure of peripheral blood mononuclear cells from EBV immune individuals led to IFN-gamma secretion, which was apparent within 6 h after virus contact and peaked 12-24 h after induction. Live, ultraviolet-light-irradiated and heat-inactivated virions all caused IFN-gamma secretion. In contrast, blood mononuclear cells from EBV non-immune adults or neonates could not be activated to IFN-gamma production by EBV.
mesh_terms: D002478:Cells, Cultured; D006566:Herpesviridae Infections / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D013997:Time Factors
chemical_list: D007371:Interferon-gamma