title: Identification of shellfish fatty acids and their effects on lipogenic enzymes.
abstract: The fatty acids which are common to and characteristic of shellfish, were identified by mass spectrometry and NMR  spectral analyses as being: octadecatetraenoioc acid, eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid. When the fatty acids isolated by high performance liquid chromatography were separately intubated into rats, hepatic glucose-6-phosphate dehydrogenase (EC 1.1.1.49), malic enzyme (EC 1.1.1.40) and acetyl-CoA carboxylase (EC 6.4.1.2) were reduced more effectively as compared with linoleic acid intubation. These enzymes were reduced most markedly by eicosapentaenoic acid-intubation. The fatty acids seem to be effective components in reduction of triacylglycerol and lipogenic enzyme levels in rats fed on shellfish.
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000818:Animals; D004281:Docosahexaenoic Acids; D004537:Eicosanoic Acids / Q000032:analysis; D015118:Eicosapentaenoic Acid; D005231:Fatty Acids, Unsaturated / Q000032:analysis* / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008974:Mollusca / Q000032:analysis*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D004537:Eicosanoic Acids; D005231:Fatty Acids, Unsaturated; D014280:Triglycerides; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D008025:Ligases; D000103:Acetyl-CoA Carboxylase; C026219:docosapentaenoic acid; C013641:parinaric acid