Efficacy of ACTH 4-9 analog, methylphenidate, and placebo on attention deficit disorder with hyperkinesis.
The present study compared the efficacy of ACTH 4-9 analog, methylphenidate, and placebo on attention deficit disorder with 30 (HK) children with attention deficit disorder and psychometric measurements. HK children were randomly placed into three groups, according to body weight, and treated with placebo, methylphenidate, and adrenocorticotropic hormone fractions (ACTH 4-9 analog). The results revealed that HK children on methylphenidate manifested a significantly greater vasomotor reactivity, behavioral improvement, and learning receptivity than HK children taking ACTH 4-9 analog and/or placebo. Future research implications with ACTH 4-9 and HK children are discussed.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002648:Child; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000627:therapeutic use*; D011897:Random Allocation
D010446:Peptide Fragments; D008774:Methylphenidate; C028024:ACTH (4-9); D000324:Adrenocorticotropic Hormone