The effects of beta-adrenergic receptor blockade on the inhibition of gastric acid secretion, and the release of pancreatic polypeptide by antral distension in healthy subjects.
In a randomized double-blind study of seven healthy subjects an intravenous injection of metoprolol and propranolol did not change the submaximal gastric acid response to pentagastrin. The inhibition of pentagastrin-stimulated acid secretion by balloon distension of the antrum was unchanged by a preceding intravenous injection of metoprolol or propranolol. The plasma level of pancreatic polypeptide in peripheral venous blood showed a significant rise during antral distension. This rise was unaltered by a preceding injection of metoprolol and slightly depressed by propranolol. We conclude that the inhibitory effect of antral distension on gastric acid secretion in healthy subjects is not mediated by beta 1 or beta 2-adrenergic mechanisms. The reflex release of pancreatic polypeptide by antral distension may possibly involve a weak beta 2-adrenergic component.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D011706:Pyloric Antrum / Q000502:physiology*; D011897:Random Allocation; D012636:Secretory Rate / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D010455:Peptides; D011433:Propranolol; D010418:Pentagastrin; D008790:Metoprolol