Maturation of the fetal lung II. Effect of hyperoxia on phosphatidic acid phosphatase, pyruvate kinase and superoxide dismutase activity in the newborn rat lung.
Oxygen-induced lung toxicity was studied in newborn rats. Three-day-old rats were exposed to 85-90% oxygen or air for 48 h. The activity of pulmonary antioxidant defenses, as measured by the activity of superoxide dismutase (SOD), showed a progressive increase in activity. The activity of phosphatidic acid phosphatase (PAPase) showed a statistically significant decrease in the oxygen-poisoned lung. In the activity of pulmonary pyruvate kinase no significant change occurred. After two days of oxygen exposure (FiO2 085-0.9) marked histological changes appeared including an increased number of interstitial cells, atelectasis, pulmonary oedema, diminution of lamellar content, loose lamellar bodies and increasing tubular myelin in the alveolar space.
D000818:Animals; D000831:Animals, Newborn; D001273:Atmosphere Exposure Chambers; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008854:Microscopy, Electron; D010100:Oxygen / Q000633:toxicity*; D010711:Phosphatidate Phosphatase / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D011770:Pyruvate Kinase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism*
D013482:Superoxide Dismutase; D011770:Pyruvate Kinase; D010744:Phosphoric Monoester Hydrolases; D010711:Phosphatidate Phosphatase; D010100:Oxygen