title: Use of pentagastrin test as a combined teaching and research project for medical students.
abstract: The pentagastrin acid-secretion test was used to teach medical students gastric investigation, the structure of a controlled trial, and the application of non-parametric statistics to the analysis of imperfect data. This teaching project also yielded considerable original data from 150 subjects on the extra-gastric effects of pentagastrin and histamine-receptor antagonists. Some, but not all, of the somatic symptoms induced by pentagastrin were abolished by cimetidine; however, the combination of pentagastrin and cimetidine induced a significant (p < 0.02) incidence of dizziness.
mesh_terms: D002927:Cimetidine / Q000494:pharmacology; D004311:Double-Blind Method; D004501:Education, Medical; D005745:Gastric Acidity Determination / Q000379:methods; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D010418:Pentagastrin / Q000009:adverse effects / Q000037:antagonists & inhibitors; D012107:Research Design; D013337:Students, Medical; D013663:Teaching
chemical_list: D002927:Cimetidine; D010418:Pentagastrin