title: Heme degradation with participation of the superoxide radical in the presence of NADH and lipoamide dehydrogenase.
abstract: Hemin degradation was observed in the presence of NADH and lipoamide dehydrogenase at pH 6.5-9.0. The degradation was inhibited by 80% by catalase and by 70% by superoxide dismutase. This system oxidized oxyhemoglobin to methemoglobin but only slightly degraded heme in hemoglobin.
mesh_terms: D000818:Animals; D002374:Catalase / Q000494:pharmacology; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism*; D006418:Heme / Q000378:metabolism*; D006427:Hemin / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D009243:NAD / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*
chemical_list: D009243:NAD; D013481:Superoxides; D006418:Heme; D006427:Hemin; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D008058:Dihydrolipoamide Dehydrogenase