title: [Role of adenylate kinase, AMP deaminase and 5'-nucleotidase in the metabolism of adenylic nucleotides].
abstract: The activities of adenylate kinase, AMP-deaminase and 5'-nucleotidase in various tissues of the rat were studied. The activity of the forward adenylate kinase reaction (ATP + AMP----2 ADP) against the back one (2 ADP----ATP + AMP) was predominant. The liver was shown to contain two, while the blood serum--three adenylate kinase isoenzymes. In the skeletal muscles, the catabolism of adenylic acid involving AMP-deaminase and 5'-nucleotidase predominantly occurred via deamination, in the liver--via dephosphorylation, while in the leucocytes, erythrocytes and blood serum the activity of these processes was essentially the same. In vitro, ATP enhanced the activity of AMP-deaminase in the liver, leucocytes and erythrocytes and decreased it in the blood serum. Under effects of ATP, the activity of 5'-nucleotidase in the leucocytes and blood serum was markedly elevated, that in the liver and erythrocytes was unaffected.
mesh_terms: D015720:5'-Nucleotidase; D000659:AMP Deaminase / Q000097:blood / Q000378:metabolism*; D000227:Adenine Nucleotides / Q000097:blood / Q000378:metabolism*; D000263:Adenylate Kinase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000201:enzymology; D009708:Nucleotidases / Q000097:blood / Q000378:metabolism*; D009709:Nucleotide Deaminases / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D000227:Adenine Nucleotides; D007527:Isoenzymes; D010770:Phosphotransferases; D000263:Adenylate Kinase; D009708:Nucleotidases; D015720:5'-Nucleotidase; D009709:Nucleotide Deaminases; D000659:AMP Deaminase
vernacular_title: Rol' adenilatkinazy, AMP-dezaminazy i 5'-nukleotidazy v metabolizme adenilovykh nukleotidov.