The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
Repeated electroconvulsive shock did not alter the anticonvulsant effect of THIP in rats, although it did elevate basal rectal temperature and abolish the hypothermic response to THIP.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001812:Blood-Brain Barrier; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology; D012684:Sensory Thresholds / Q000502:physiology
D000927:Anticonvulsants; D007555:Isoxazoles; D010080:Oxazoles; D011963:Receptors, GABA-A; C015542:gaboxadol; D010433:Pentylenetetrazole