[Reactions of an identified edible snail neuron to application of peptides, mediators, prostaglandins, and cyclic nucleotides].
Extracellular application of some peptides (oxytocin, Lys-vasopressin, Leu-enkephalin) to neuron RPal induced pacemaker potentials generation and initiated or increased bursting activity. Norepinephrine and prostaglandins E1 and E2 effects on neuron RPal electric activity were qualitatively similar to those produced by oxytocin and Lys-vasopressin. Dibutyryl-cAMP, papaverine (phosphodiesterase inhibitor) and sodium fluoride (nonspecific adenylate cyclase activator) induced or potentiated bursting activity. It is supposed that oxytocin, Lys-vasopressin, Leu-enkephalin, norepinephrine and E group prostaglandins effects are mediated by intracellular processes related to activation of adenylate cyclase and increase of cAMP level in the neuron.
D000818:Animals; D005724:Ganglia / Q000166:cytology / Q000187:drug effects; D006372:Helix, Snails / Q000502:physiology*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D009712:Nucleotides, Cyclic / Q000494:pharmacology*; D010208:Papaverine / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*; D012969:Sodium Fluoride / Q000494:pharmacology
D018377:Neurotransmitter Agents; D009712:Nucleotides, Cyclic; D010455:Peptides; D011453:Prostaglandins; D012969:Sodium Fluoride; D010208:Papaverine
Reaktsii identifitsirovannogo neĭrona vinogradnoĭ ulitki na applikatsiiu peptidov, mediatorov, prostaglandinov i tsiklicheskikh nukleotidov.