Cardiovascular effects of etilefrine hydrochloride during abdominal aortic surgery.
To counteract the decrease in blood pressure after release of the aortic cross-clamp, 2 mg etilefrine hydrochloride (Effortil; Boehringer Ingelheim) was administered intravenously to 13 patients undergoing aortofemoral bypass operations. It caused a statistically significant increase in mean arterial pressure, cardiac index, pulmonary capillary wedge pressure and left and right ventricular stroke work index. No significant changes were found in total peripheral resistance.
D000368:Aged; D001012:Aorta, Abdominal / Q000601:surgery*; D001014:Aortic Aneurysm / Q000503:physiopathology / Q000601:surgery; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery; D005039:Etilefrine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D010656:Phenylephrine / Q000031:analogs & derivatives*; D013268:Stimulation, Chemical
D010656:Phenylephrine; D005039:Etilefrine