title: [3H] dynorphin binding to guinea pig and rat brain.
abstract: [3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorphin binding is displaced by morphine, suggesting a mu as well as kappa component. Consequently, in rat, dynorphin may show effects at both mu and kappa receptors in vivo.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004399:Dynorphins; D004723:Endorphins / Q000378:metabolism*; D006168:Guinea Pigs; D007700:Kinetics; D009020:Morphine / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism*; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu
chemical_list: D004723:Endorphins; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; C030738:dynorphin receptor; D004399:Dynorphins; D009020:Morphine