title: Basic properties of beta adrenergic receptors mediating melanosome dispersion of melanophores in a cyprinid fish, Zacco temmincki.
abstract: In melanophores of a cyprinid fish, Zacco temmincki, receptor mechanisms of melanosome dispersion induced by catecholamines were examined. While possessing a melanosome-aggregating action in higher concentrations, isoproterenol and epinephrine in lower concentrations acted to disperse melanosomes. Norepinephrine, epinine and dopamine altered their action from melanosome aggregation to melanosome dispersion after alpha adrenergic blockade. The catecholamine-induced melanosome dispersion was inhibited by beta adrenergic blocking agents. Mediation of dispersion is regulated through beta adrenergic receptors. The beta adrenergic responses were unaffected by mersalyl, a sulfhydryl inhibitor. A prospective substance acting in dispersing melanosomes appears to be adrenaline, but not noradrenaline.
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D003530:Cyprinidae / Q000378:metabolism* / Q000502:physiology*; D008544:Melanocytes / Q000378:metabolism*; D008547:Melanophores / Q000378:metabolism*; D008550:Melatonin / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
chemical_list: D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; D008550:Melatonin