Ipomeanol 4-glucuronide, a major urinary metabolite of 4-ipomeanol in the rat.
Urinary excretion and metabolism of 4-ipomeanol was studied in rats injected ip with the radiolabeled compound. There was a rapid elimination of radioactivity in the urine, amounting to 47% of the administrated dose within 4hr. One major metabolite was isolated and purified by HPLC. Analysis by analytical HPLC, beta-glucuronidase hydrolysis, and mass spectrometry identified this material as ipo-meanol 4-glucuronide. The large amount of this metabolite excreted suggests that 4-glucuronidation is an important detoxication reaction in vivo for 4-ipomeanol in rats.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005663:Furans / Q000378:metabolism / Q000652:urine; D005965:Glucuronates / Q000652:urine*; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000378:metabolism* / Q000652:urine*; D014118:Toxins, Biological / Q000378:metabolism*
D005663:Furans; D005965:Glucuronates; D013729:Terpenes; D014118:Toxins, Biological; C034043:ipomeanol 4-glucuronide; C001470:4-ipomeanol