Occurrence of amantadine- and rimantadine-resistant influenza A virus strains during the 1980 epidemic.
The sensitivities to amantadine and rimantadine of influenza A virus epidemic strains were assayed by the haem-adsorption reduction test in mouse Ehrlich ascites cells in comparison with prototype strains and a rimantadine-resistant mutant. Besides a majority of sensitive strains, two relatively resistant epidemic strains were identified. The possible origin of resistant strains and their importance for medical practice are discussed.
D000218:Adamantane / Q000031:analogs & derivatives*; D000547:Amantadine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D012299:Rimantadine / Q000494:pharmacology*
D012299:Rimantadine; D000547:Amantadine; D000218:Adamantane