[Hormonal induction of liver tyrosine aminotransferase in animals with chronic poisoning by hepatotropic poisons].
A study has been made of the effect of ethanol and CCl4 on hormonal induction of tyrosine aminotransferase in mouse liver. Both the hepatotropic poisons administered for a long time lose the induction effect and considerably reduce the same effect exerted by hydrocortisone. Microscopic study has revealed fatty dystrophy of the liver cells and even the formation of the areas of necrosis as a result of administering CCl4. The liver tissue stroma has been shown to develop reactive inflammation.
D000437:Alcoholism / Q000201:enzymology* / Q000473:pathology; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology* / Q000473:pathology; D002908:Chronic Disease; D004790:Enzyme Induction / Q000187:drug effects; D006651:Histocytochemistry; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D008808:Mice, Inbred CBA; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D014444:Tyrosine Transaminase; D006854:Hydrocortisone
Gormonal'naia induktsiia tirozinaminotransferazy pecheni zhivotnykh v usloviiakh khronicheskoĭ intoksikatsii nekotorymi gepatotropnymi iadami.