Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy.
Post-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts. Reduction or discontinuance of immunosuppression caused regression of the lesions, often without subsequent rejection of the grafts. Chemotherapy and irradiation were not valuable. The findings may influence policies about treating other kinds of post-transplantation neoplasms.
D000293:Adolescent; D000328:Adult; D002102:Cadaver; D003524:Cyclosporins / Q000009:adverse effects*; D005260:Female; D016027:Heart Transplantation; D006566:Herpesviridae Infections / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation; D016031:Liver Transplantation; D016040:Lung Transplantation; D008223:Lymphoma / Q000209:etiology*; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D011241:Prednisone / Q000009:adverse effects*; D014184:Transplantation, Homologous
D003524:Cyclosporins; D011241:Prednisone