title: Effect of monocular deprivation on uptake and binding of [3H]glutamate in the visual system of rat brain.
abstract: [3H]Glutamate uptake and binding studies were performed in the visual cortices, lateral geniculate nuclei (LGN), and superior colliculi of 3-month-old rats with one eyelid surgically closed from postnatal day 10 (monocular deprivation). Uptake and binding were highest in the lateral geniculate nucleus followed by the visual cortex (69% and 15%, respectively compared to LGN values) and the superior colliculus (32% and 59% of LGN values). Monocular deprivation did not affect [3H]glutamate uptake in any of the visual regions examined. However, a 46% decrease in [3H]glutamate binding in the lateral geniculate nucleus ipsilateral to the sutured eye was detected. Binding levels in other regions were not affected.
mesh_terms: D000818:Animals; D001766:Blindness; D001921:Brain / Q000254:growth & development*; D005260:Female; D005829:Geniculate Bodies / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D008297:Male; D051381:Rats; D013477:Superior Colliculi / Q000378:metabolism*; D014785:Vision, Ocular / Q000502:physiology*; D014793:Visual Cortex / Q000378:metabolism*
chemical_list: D005971:Glutamates; D018698:Glutamic Acid