Cholinergic effects of cimetidine and ranitidine.
Cimetidine and ranitidine were submitted to eight in vitro assays: their intrinsic activity was evaluated on guinea-pig auricles and ileum, acetylcholine synergism on guinea-pig tracheal muscle, frog rectus abdominis, guinea-pig vas and rat phrenic nerve diaphragm, and antagonism on guinea-pig auricles and rat jejunum estimated at a range of concentrations. Ranitidine alone opposed 1-hyoscyamine antagonism in guinea-pig ileum when acetylcholine was the agonist, but not when the agonist was bethanechol.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001001:Anura; D001285:Atropine / Q000494:pharmacology; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology*; D004357:Drug Synergism; D005663:Furans / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010277:Parasympathomimetics; D011899:Ranitidine; D051381:Rats
D001626:Bethanechol Compounds; D005663:Furans; D006146:Guanidines; D010277:Parasympathomimetics; D018723:Bethanechol; D001285:Atropine; D002927:Cimetidine; D011899:Ranitidine; D000109:Acetylcholine