title: Desacetyl-1-nantradol: a selective prostaglandin antagonist.
abstract: Progress in understanding the action of specific prostaglandins will be facilitated by the discovery of specific antagonists to different types of prostaglandin receptors. It has been suggested that nantradol, a cannabinoid-related compound with strong analgetic properties, is an antagonist for prostaglandin receptors. The interaction of nantradol with the receptors for prostaglandin D2 and prostaglandin I2/E1 on human platelets was examined. Desacetyl-1-nantradol, the active form of the drug, blocked the binding of prostaglandin D2 to platelets and the PGD2-induced stimulation of adenylate cyclase activity, but had no effect on the interaction of prostaglandin E1 with platelets. The data support the hypothesis that desacetyl-1-nantradol binds selectively to some classes of prostaglandin receptors and also suggest that it may be useful for distinguishing among different types of prostaglandin receptors.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000527:Alprostadil; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D010617:Phenanthridines / Q000494:pharmacology*; D011457:Prostaglandins D / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin / Q000187:drug effects*; D018078:Receptors, Prostaglandin E
chemical_list: D010617:Phenanthridines; D011457:Prostaglandins D; D011458:Prostaglandins E; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; D018078:Receptors, Prostaglandin E; C032426:desacetylnantradol; D000262:Adenylyl Cyclases; D000527:Alprostadil; C036293:prostaglandin D2 receptor