Exogenously stimulated gastric secretion in dogs after ganglion and sympathetic blockade and antral acidification.
1 In conscious dogs with gastric fistulae, Heidenhain pouches and in some cases, innervated pyloric pouches, ganglionic blockade augmented Heidenhain pouch acid secretion only if the gastric fistula remained closed in animals receiving pentagastrin. 2 Ganglionic blockade depressed methacholine-stimulated acid and pepsin secretion from the Heidenhain pouch whether or not the fistula was open. 3 Acidification of the antral pouch consistently augmented the acid and pepsin secretion from the Heidenhain pouch when either pentagastrin or methacholine was the stimulus. Ganglionic blockade prevented this.
D000818:Animals; D004285:Dogs; D005730:Ganglionic Blockers / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000294:innervation / Q000378:metabolism / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010425:Pentolinium Tartrate / Q000494:pharmacology; D010434:Pepsin A / Q000494:pharmacology; D011706:Pyloric Antrum / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology*
D005730:Ganglionic Blockers; D011943:Receptors, Adrenergic, beta; D013565:Sympatholytics; D010425:Pentolinium Tartrate; D010434:Pepsin A; D010418:Pentagastrin