Steroid sulphatase deficiency associated with testis cancer.
2 patients with recessive X-linked ichthyosis and steroid sulphatase (STS) deficiency were found to have testis cancer. It is suggested that STS deficiency may predispose both to cryptorchidism and to testis cancer.
D000328:Adult; D004407:Dysgerminoma / Q000209:etiology / Q000235:genetics; D006801:Humans; D007057:Ichthyosis / Q000235:genetics; D008297:Male; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000172:deficiency* / Q000235:genetics; D013724:Teratoma / Q000209:etiology / Q000235:genetics; D013736:Testicular Neoplasms / Q000209:etiology* / Q000235:genetics
D013429:Sulfatases; D043266:Steryl-Sulfatase