Comparative effect of the induction of the subunits of rat liver glutathione S-transferases by butylated hydroxytoluene.
When butylated hydroxytoluene (BHT) was administered to rats, the smallest subunit Ya (Mr 22,000) of rat liver GSH S-transferases was found to undergo maximum induction. It is suggested that the differential induction of GSH S-transferase activities by BHT towards different substrates may be due to the differences in the induction of the constituent subunits of GSH S-transferases.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000096:biosynthesis* / Q000302:isolation & purification / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002084:Butylated Hydroxytoluene; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase