title: [The role of mediators in the genesis of convulsive activity. Biogenic monoamine content of the brain of rats with various predispositions to audiogenic convulsions].
abstract: Content of serotonin, tryptophane, adrenaline, noradrenaline, dopamine, DOPA and tyrosine in was studied in cerebellum, truncus cerebri, hypothalamus and brain hemispheres of rats with various predisposition to audiogenic convulsions. Distinct decrease in content of brain serotonin, noradrenaline and increase in dopamine content was noted in rats with high level of audiogenic convulsive activity. The data obtained suggest that the increase in dopamine and decrease in serotonin and noradrenaline content in brain tissue may be among the factors responsible for elevation of potential convulsive activity of central nervous system.
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012640:Seizures / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Izuchenie roli mediatorov v formirovanii sudorozhnoĭ gotovnosti. Soderzhanie biogennykh monoaminov v golovnom mozge krys s razlichnoĭ predraspolozhennost'iu k audiogennym sudorogam.