Response of the renal pacemaker to beta 1-adrenoceptor agonist: difference from the cardiac pacemaker.
Electromyographic responses of the canine-pyeloureter to dobutamine, a beta 1-adrenoceptor agonist were investigated in vitro. Dobutamine produced a marked enhancement of potential in the pelvicalyceal (PC-) border, but failed to evoke noticeable responses in the renal pelvis and ureter. Dobutamine, however, made the pacemaker rhythm a little slow. This finding shows that the renal pacemaker is somewhat different form the cardiac pacemaker, pace of which is quickened by dobutamine.
D000200:Action Potentials / Q000187:drug effects; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology*; D004285:Dogs; D004576:Electromyography; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006329:Heart Conduction System / Q000502:physiology; D066298:In Vitro Techniques; D010528:Peristalsis / Q000187:drug effects*; D011312:Pressure; D014513:Ureter / Q000294:innervation* / Q000502:physiology
D000318:Adrenergic beta-Agonists; D002395:Catecholamines; D004280:Dobutamine