[Effect of vitamin B3-active compounds on the content of free and combined gamma-aminobutyric acid and glutamic acid in the brain of mice].
The bound and free GABA and glutamic acid content in the brain of F1 (CBA X C57B1/6) hybrid mice was investigated by the Eliott method. A tendency to a decrease of GABA and glutamate content in the brain with their practically constant bound/free ratio was observed 24 h after calcium-D-pantothenate injections (150 mumole/kg, 9 injections for 3 days). Calcium-D-homopantothenate injected in the same way caused a significant decrease in the GABA content, and a sharp drop of the bound/free GABA ratio. The effect is not associated with the influence of calcium ions in the composition of the injected compounds.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D051379:Mice; D008815:Mice, Inbred Strains; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology
D005971:Glutamates; C016030:pantogab; D010205:Pantothenic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D002118:Calcium
Vliianie B3-vitaminoaktivnykh soedineniĭ na soderzhanie svobodnykh i sviazannykh gamma-aminomaslianoĭ i glutaminovoĭ kislot v golovnom mozgu mysheĭ.