Stress-induced reduction of gastric acid in the rat is not associated with increased tissue somatostatin.
In zero, mildly and severely stressed rats, gastric acid secretion, aortal and portal venous gastrin, venous glucagon and somatostatin in gastric, duodenal mucosa and in pancreas were examined. Serum gastrin and gastric acid secretion are reduced markedly by both kinds of stress, whereas plasma glucagon rises steadily with stress. As somatostatin in the tissues of stressed rats is not different from unstressed controls, gastrin and gastric acid reduction may not be attributed to an endocrine or paracrine action of somatostatin.
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000032:analysis / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005934:Glucagon / Q000097:blood; D007413:Intestinal Mucosa / Q000032:analysis; D008297:Male; D010179:Pancreas / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000032:analysis / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*
D005755:Gastrins; D013004:Somatostatin; D005934:Glucagon