title: Studies on the effect of the pyrethroid insecticide Decamethrin on ionic transport through the in vitro skin of Rana esculenta.
abstract: The effect of the insecticide Decamethrin on ionic transport through the isolated skin of Rana esculenta was studied; the skins were bathed with 1-2 mEq Na2SO4 or choline-Cl solutions (exterior), and with Ringer normal (interior). Under open circuit (OC) conditions, mucosal Decamethrin (10(-6) M), did not provoke changes in Na+ fluxes. At 10(-5) M there was a slight inhibition of the JoNa+ after 30 min. The Cl- fluxes did not change. With longer treatments (60-90 min, OC, 10(-5) M) the JnNa+ was inhibited; at 10(-4) M it was augmented. The JnH+ was not affected. Serosal Decamethrin did not modify Na+ and H+ fluxes. In short circuit conditions, Decamethrin (10(-5) M) in the mucosal face inhibited the JnNa+; the JnH+ did not change in these conditions. The abscence of interaction of mucosal Decamethrin with Amiloride was shown.
mesh_terms: D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002712:Chlorides; D007306:Insecticides / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D009570:Nitriles; D011522:Protons; D011722:Pyrethrins / Q000494:pharmacology*; D011893:Rana esculenta; D012867:Skin / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
chemical_list: D002712:Chlorides; D007306:Insecticides; D007473:Ion Channels; D009570:Nitriles; D011522:Protons; D011722:Pyrethrins; C017180:decamethrin; D000584:Amiloride; D012964:Sodium