Histamine H2-antagonists modify gastric emptying in the rat.
1 Histamine H2-receptor antagonists were tested for their effect on gastric emptying in the rat. 2 At low doses all the compounds were inactive except for burimamide which delayed and ranitidine which accelerated gastric emptying. 3 At high doses burimamide, metiamide, cimetidine and oxmetidine delayed, whereas ranitidine accelerated gastric emptying; tiotidine remained ineffective. 4 Changes in emptying rate were not accompanied by changes in emptying pattern which, with all the compounds examined, proceeded, as in the controls, by apparent first order kinetics. 5 The mechanism of the ranitidine-induced acceleration of gastric emptying seemed to be connected with an interference with the cholinergic system, whereas the mechanism of cimetidine- and oxmetidine-induced slowing of gastric emptying was apparently related to cholinolytic and possibly also relaxant effects of the compounds. 6 These different effects of the various H2-blockers are consistent with the idea that changes in emptying rate are independent of H2-receptor blockade.
D000818:Animals; D005663:Furans / Q000494:pharmacology; D005746:Gastric Emptying / Q000187:drug effects*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D011899:Ranitidine; D051381:Rats; D011919:Rats, Inbred Strains
D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine