[Experimental study of the interaction of nonsteroidal anti-inflammatory agents--voltaren and acetylsalicylic acid--with beta-adrenoblockers].
It has been demonstrated in rat experiments that the beta-adrenoblockers propranolol and pindolol differ in the influence on the therapeutic and toxic effects of voltaren and acetylsalicylic acid. Propranolol has an analgetic action of its own, reducing the analgetic and antiinflammatory effects of voltaren and acetylsalicylic acid. It potentiates the antipyretic effect of voltaren and ulcerogenic action of both nonsteroidal antiinflammatory drugs. Pindolol exerts both analgetic and antiinflammatory action and does not affect the antipyretic effect of voltaren and ulcerogenic action of nonsteroidal antiinflammatory drugs. The difference in the action of the beta-adrenoblockers under study is likely to be linked with the characteristics of their pharmacological action spectrum.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D010648:Phenylacetates / Q000494:pharmacology*; D010869:Pindolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D000319:Adrenergic beta-Antagonists; D000893:Anti-Inflammatory Agents; D010648:Phenylacetates; D004008:Diclofenac; D011433:Propranolol; D010869:Pindolol; D001241:Aspirin
Izuchenie vzaimodeĭstviia nesteroidnykh protivospalitel'nykh sredstv--vol'tarena i atsetilsalitsilovoĭ kisloty--s beta-adrenoblokatorami v éksperimente.