Effects of taxol and nocodazole on insulin secretion from isolated rat islets of Langerhans.
Taxol, a promotor of microtubule polymerization, and nocodazole, which induces microtubule depolymerization, used at concentrations known to be specific for these effects in other cell types, were each shown to inhibit glucose-stimulated insulin secretion from isolated rat islets of Langerhans. These findings suggest that the dynamic regulation of microtubule polymerization-depolymerization in pancreatic B cells may be important for insulin secretion via the microtubule-microfilamentous system.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D015739:Nocodazole; D017239:Paclitaxel; D051381:Rats; D011919:Rats, Inbred Strains
D000470:Alkaloids; D001562:Benzimidazoles; D007328:Insulin; D005947:Glucose; D017239:Paclitaxel; D015739:Nocodazole