Barrier pressure and muscle relaxants. Comparison of the effects of pancuronium and vecuronium on the lower oesophageal sphincter.
The effects of pancuronium and vecuronium on the lower oesophageal sphincter pressure were studied in 24 healthy patients anaesthetised with 0.5% halothane in nitrous oxide and oxygen. Following pancuronium 0.1 mg/kg intravenously, there was a significant increase in barrier pressure from a control value of 2.0 (SEM 0.14) kPa to 3.0 (SEM 0.27) kPa 1 minute after injection (p less than 0.05). This increase was sustained throughout the 15 minute period of recording and was accompanied by a significant increase in heart rate (p less than 0.001). Following administration of vecuronium 0.1 mg/kg intravenously there was an initial modest, though not significant increase in barrier pressure. This increase was significant (p less than 0.05) at 15 minutes. There were no cardiovascular changes following vecuronium.
D000769:Anesthesia, Inhalation; D001794:Blood Pressure / Q000187:drug effects; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009609:Nitrous Oxide; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011312:Pressure; D011897:Random Allocation; D013270:Stomach / Q000502:physiology; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium; D009609:Nitrous Oxide; D006221:Halothane