Induction of tyrosine aminotransferase under the influence of D-galactosamine.
The induction of the tyrosine aminotransferase by tyrosine and by tryptophan + methionine is completely inhibited by 375 mg/kg D-galactosamine-HCl. The hydrocortisone induction is reduced in dependence on the amount of D-galactosamine. Tryptophan protects to some extent the influence of low doses of D-galactosamine on the hydrocortisone induction of tyrosine aminotransferase.
D000818:Animals; D004790:Enzyme Induction; D005688:Galactosamine / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008715:Methionine / Q000494:pharmacology; D009536:Niacinamide / Q000494:pharmacology; D051381:Rats; D014364:Tryptophan / Q000494:pharmacology; D014443:Tyrosine / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D009536:Niacinamide; D014443:Tyrosine; D005688:Galactosamine; D014364:Tryptophan; D008715:Methionine; D014444:Tyrosine Transaminase; D006854:Hydrocortisone