Modulation of the slow inward Ca2+ current by adrenaline in bullfrog sympathetic ganglion cells.
The slow inward current, which is carried almost exclusively by Ca2+, was disclosed by voltage-clamp study on bullfrog sympathetic ganglion cells in Ringer solution. This current was confirmed to be markedly depressed by the action of adrenaline, suggesting that adrenaline modulates the Ca2+ influx of ganglion cells under physiological conditions.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000502:physiology*; D004837:Epinephrine / Q000494:pharmacology / Q000502:physiology*; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D018377:Neurotransmitter Agents; D011892:Rana catesbeiana; D013779:Tetrodotoxin / Q000494:pharmacology
D007473:Ion Channels; D018377:Neurotransmitter Agents; D013779:Tetrodotoxin; D002118:Calcium; D004837:Epinephrine