Sensitivity of hippocampal neurons to glutamic acid and its analogues.
In thin slices of the guinea-pig hippocampus, depolarizations induced by glutamate (Glu) and its analogues were studied by intracellular recording. It was found that Glu induced stereospecific responses, that L-Glu was more potent than homocysteate and N-methyl-D-aspartate. It is probable that the high-affinity uptake mechanism played a decisive role in termination of L-Glu excitation.
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects*; D006710:Homocysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008968:Molecular Conformation; D011956:Receptors, Cell Surface / Q000502:physiology; D017470:Receptors, Glutamate; D013237:Stereoisomerism
D005971:Glutamates; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate; D006710:Homocysteine; C007956:homocysteic acid; D001224:Aspartic Acid; D018698:Glutamic Acid