[Glutamate as a transmitter in the CNS and its presumed significance in the pathogenesis of cerebral seizure forms--recent aspects].
Glutamate is believed to be quantitatively the most outstanding of the excitatory transmitters in the CNS. Certain conformationally related analogues, e. g. kainate, N-methyl-D-aspartate, ibotenate, and homocysteate, act as glutamate agonists. The local or systemic administration of these "excitotoxic" compounds induces epileptiform activity pointing out new and deeper insights into the epileptic process. Additionally, the glutamate transmitter hypothesis is expected to give a chance of a causal comprehension for choreatic processes as well as for the mode of action of anticonvulsant and antispastic agents.
D001921:Brain / Q000503:physiopathology; D004827:Epilepsy / Q000503:physiopathology*; D005071:Evoked Potentials; D005971:Glutamates / Q000502:physiology*; D018698:Glutamic Acid; D006801:Humans; D009434:Neural Pathways / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005971:Glutamates; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid
Glutamat als Transmitter im ZNS und seine mutmassliche Bedeutung für die Pathogenese zerebraler Anfallsformen--neuere Aspekte.