title: Effects of naloxone on the insulin and GH responses to alpha-adrenergic stimulation with clonidine.
abstract: To find if endorphins can influence hormonal responses mediated by noradrenergic pathways, we examined the effects of naloxone, an opiate receptor blocker, on the GH and insulin responses to clonidine, a drug which acts by stimulation of alpha-adrenergic receptors. Intravenous clonidine (0.15 mg in 10 min) induced a significant fall of plasma insulin and a marked increase of plasma GH. Intravenous naloxone (bolus of 1.6 mg followed by 50 micrograms/min) did not change the insulin response to clonidine, and seemed to induce only a slight delay in the GH response.
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003000:Clonidine / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects
chemical_list: D000316:Adrenergic alpha-Agonists; D001786:Blood Glucose; D007328:Insulin; D011957:Receptors, Opioid; D009270:Naloxone; D013006:Growth Hormone; D003000:Clonidine