Transient glomerular proteinuria, enzymuria, and nephrotoxic reaction induced by radiocontrast media.
Contrast nephropathy is a recognized complication of arteriographic procedures; usually, it consists of a mild deterioration of renal function. In an attempt to understand better the mechanisms involved, we conducted a prospective study before and after arteriography that monitored the urinary elimination of high- and low-molecular weight proteins, the urinary activity of tubular enzymes, and renal clearances of 27 patients. We detected a noticeable and transient nonselective proteinuria of glomerular origin together with moderate signs of tubular damage and a stable renal function. We did not identify any risk factor. Contrast media may alter the disposition of charges along the glomerular filtering membrane in a way that promotes proteinuria; consequently, the massive flow of proteins may injure the tubular cells.
D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000139:chemically induced; D000626:Aminopeptidases / Q000652:urine; D018826:CD13 Antigens; D002648:Child; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000652:urine; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011507:Proteinuria / Q000139:chemically induced*; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging; D014168:Transferrin / Q000652:urine
D003287:Contrast Media; D007074:Immunoglobulin G; D014168:Transferrin; D003404:Creatinine; D000118:Acetylglucosaminidase; D000626:Aminopeptidases; D018826:CD13 Antigens