Plaque morphology and pathogenicity for newborn mice of swine vesicular disease virus. II. Temperature-dependent mutants and their clones.
From wild swine vesicular disease virus (SVDV) strains temperature-dependent (td) mutants td 27 degrees C, td 32 degrees C and td 42 degrees C were derived. Differences were noted in their pathogenicity for newborn mice. The non-homogeneity of the td populations was manifested by formation of plaques of various sizes and confirmed by differential pathogenicity of the clones derived from them. A higher pathogenicity of the td mutants and their clones was associated not only with larger plaques, but also with higher temperature permissive for the given mutant. The td 27 degrees C mutants were not virulent for newborn mice, similarly to the attenuated SVDV strain and its clones.
D000818:Animals; D000831:Animals, Newborn / Q000382:microbiology; D004770:Enterovirus / Q000472:pathogenicity*; D004771:Enteroviruses, Porcine / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D005814:Genes, Viral; D051379:Mice; D009154:Mutation; D013696:Temperature; D010948:Viral Plaque Assay; D014774:Virulence