Effects of hypothalamic lesions on the content of dynorphin immunoreactivity in pituitary.
Radiofrequency lesion of medial basal hypothalamus (MBH) caused a approximately 50% depletion of immunoreactive dynorphin (ir-dyn) both in the anterior and neurointermediate lobe of the pituitary, whereas radiofrequency lesions of both supraoptic and paraventricular nuclei (SON, PVN) resulted in an approximately 30% reduction in neurointermediate lobe only. MBH cells and/or fibers contribute, therefore, to adenohypophysis pool of ir-dyn. Moreover, since the loss of ir-dyn in neurohypophysis ascertained after MBH lesion is significantly higher than that obtained with SON and PVN destruction, it may be assumed that MBH also participate to ir-dyn pool in neurohypophysis.
D000818:Animals; D004399:Dynorphins; D004723:Endorphins / Q000378:metabolism*; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011846:Radio Waves; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D004399:Dynorphins