Hepatic biotransformation in farmed blue fox and raccoon dog.
In farmed raccoon dogs and blue foxes, the hepatic content of cytochrome P-450 and the activity of polysubstrate mono-oxygenase with benzo(a)pyrene and 7-ethoxycoumarin as substrates, as well as activity of UDP glucuronosyltransferase were of the same order of magnitude as those in the laboratory rat. The amount of reduced glutathione tended to be higher in canids. There existed differences in the biotransformation activities between raccoon dogs from different farms. These cannot, however, be systematically related to the quality of food, body composition and succinate dehydrogenase activity.
D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004032:Diet; D004285:Dogs / Q000502:physiology*; D005589:Foxes / Q000502:physiology*; D008862:Microsomes, Liver / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D003577:Cytochrome P-450 Enzyme System; D013385:Succinate Dehydrogenase