title: Synthesis and pharmacological activity of some 1-alkylamino-3-(2'-methoxy-4'-diethylcarbamoyl-phenoxy)propan-2-ols.
abstract: The synthesis and pharmacological properties of some 1-alkylamino-3-(2'-methoxy-4'-diethylcarbamoylphenoxy)propan-2-ols, related to beta-adrenergic drugs, are described. The above compounds were found to possess beta 1 and beta 2-adrenolytic activity associated with local anesthetic and antiarrhythmic activities, which are clearly inferior to those of propranolol.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis*; D000777:Anesthetics; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001001:Anura; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats
chemical_list: D000319:Adrenergic beta-Antagonists; D000777:Anesthetics; D000889:Anti-Arrhythmia Agents; D011412:Propanolamines