[Screening, detection and biotransformation of lormetazepam, a new hypnotic agent from the 1,4-benzodiazepine series (author's transl)].
The paper describes a screening procedure for 7-chloro-5-(2-chlorphenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin- 2-one (lormetazepam, Noctamid) and other important analytical data (TLC, GLC, UV-, IR- and mass spectra) of this new benzodiazepine derivative. Screening results after a single p.o. dose of 1 mg lormetazepam (Noctamid-1) are also reported.
D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001569:Benzodiazepines; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006993:Hypnotics and Sedatives / Q000032:analysis / Q000378:metabolism*; D008140:Lorazepam / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; C023842:lormetazepam; D008140:Lorazepam
Screening, Nachweis und Biotransformation von Lormetazepam, einem neuen Hypnotikum aus der Reihe der 1,4-Benzodiazepine.