Cyclosporin improves Graves' ophthalmopathy.
Cyclosporin given to two patients with Graves' ophthalmopathy produced a rapid objective improvement in both, including restoration of ocular-muscle function and visual acuity, improvement in exophthalmos, and reduction in orbital muscle swelling judged by computed tomographic scan. Thyroid autoantibody levels fell with treatment, and T-cell subset abnormalities returned towards normal. In one patient an absent thyrotropin response to thyrotropin-releasing hormone became normal after treatment. These results suggest that cyclospirin treatment should be considered in patients with the congestive ophthalmopathy of Graves' disease.
D000208:Acute Disease; D001323:Autoantibodies / Q000032:analysis; D003524:Cyclosporins / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006111:Graves Disease / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000000981:diagnostic imaging; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity / Q000187:drug effects
D001323:Autoantibodies; D003524:Cyclosporins; D013954:Thyroglobulin