Intravenous buspirone self-administration in rhesus monkeys.
Rhesus monkeys trained to press levers for intravenous cocaine injections were tested with saline and various doses of buspirone, chlordiazepoxide, and clorazepate. Buspirone was not self-administered at rates significantly above saline control levels. Chlordiazepoxide and clorazepate also failed to serve as reinforcers under these conditions. The lack of reinforcing properties, taken together with the results of other preclinical behavioral studies, suggests a low potential for recreational use of buspirone in man.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002065:Buspirone; D002707:Chlordiazepoxide / Q000008:administration & dosage / Q000494:pharmacology; D003009:Clorazepate Dipotassium / Q000008:administration & dosage / Q000494:pharmacology; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D007275:Injections, Intravenous; D008253:Macaca mulatta; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D012054:Reinforcement, Psychology; D012646:Self Administration; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D012965:Sodium Chloride; D003009:Clorazepate Dipotassium; D002707:Chlordiazepoxide; D003042:Cocaine; D002065:Buspirone