title: Efficacy of ethylenediamine dihydriodide as an agent to prevent experimentally induced bovine foot rot.
abstract: Ethylenediamine dihydriodide (EDDI) was administered by capsule and as a feed premix to cattle in 2 studies. In study I (32 steers), EDDI was given at 0, 12.5, 50, and 200 mg/animal each day and in study II (36 steers) at 0, 30, and 200 mg/animal each day. Serum iodine levels were monitored during the studies. The cattle were inoculated intradermally in the interdigital space with a mixture of Fusobacterium necrophorum and Bacteroides melaninogenicus to induce acute foot rot at day 15 (study I) or day 28 (study II) after EDDI administration was started. Lesions and lameness were evaluated 5 days after challenge exposure, using a subjective scoring system. The cattle receiving EDDI had significantly less severe lesions and lameness than control cattle in both studies (study I, P less than 0.003; study II, P less than 0.001). The results indicated that EDDI was efficacious in prevention of foot rot. The studies demonstrated a direct relationship between dosage levels of EDDI and serum iodine levels. However, at the large dosage level (200 mg) there were some individuals that showed an inability to metabolize and excrete the iodine as demonstrated by high serum iodine levels (600 to 700 micrograms of iodine/dl of serum).
mesh_terms: D000818:Animals; D001442:Bacteroides Infections / Q000517:prevention & control / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D004195:Disease Models, Animal; D005029:Ethylenediamines / Q000627:therapeutic use*; D005260:Female; D005535:Foot Rot / Q000517:prevention & control*; D005674:Fusobacterium Infections / Q000517:prevention & control / Q000662:veterinary*; D005675:Fusobacterium necrophorum; D007455:Iodine / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D001443:Prevotella melaninogenica
chemical_list: D005029:Ethylenediamines; C031234:ethylenediamine; D007455:Iodine