title: Blood coagulation and platelet function following maximal exercise: effects of beta-adrenoceptor blockade.
abstract: Alterations of platelet function and blood coagulation may occur with exercise or beta-adrenoceptor blockade. To determine if beta-blockade could modify exercise-induced changes in haemostatic factors we performed a double-blind study of acute strenuous exercise in normal males with and without beta-blockade. Exercise increased prostacyclin and plasminogen activator levels but there was no evidence of thrombin generation as indicated by unchanged platelet aggregation responses, beta-thromboglobulin and fibrinopeptide A levels. The only alteration in coagulation by beta-blockade was a reduction in the factor VIII:C and VIII:RAg rise after exercise and this modification may be relevant to the protective effect of these drugs in patients with coronary artery disease.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000941:Antigens / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects*; D005169:Factor VIII / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008297:Male; D005082:Physical Exertion; D010960:Plasminogen Activators / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects*; D011460:Prostaglandins F / Q000378:metabolism; D014841:von Willebrand Factor
chemical_list: D000319:Adrenergic beta-Antagonists; D000941:Antigens; D011460:Prostaglandins F; D014841:von Willebrand Factor; D005169:Factor VIII; D010960:Plasminogen Activators; C100006:prostaglandin F1