Topical cholesterol treatment of recessive X-linked ichthyosis.
In an open prospective half-side trial, creams containing 10% cholesterol or 10% urea were applied to lesions in 20 steroid-sulphatase-deficient male patients with recessive X-linked ichthyosis. In 18 there was a good response to the cholesterol cream. In 13 patients the response to cholesterol was better than that to urea. None showed a better response to urea than to cholesterol. A reduction in the cholesterol content of the stratum corneum may be responsible for abnormal cornification in recessive X-linked ichthyosis.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000008:administration & dosage*; D002788:Cholesterol Esters / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D005808:Genes, Recessive; D008040:Genetic Linkage; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy* / Q000235:genetics; D007223:Infant; D008297:Male; D011446:Prospective Studies
D002788:Cholesterol Esters; D002784:Cholesterol; C007045:cholesteryl sulfate