title: Monoamine oxidase activity in several tissues of the goldfish. Carassius auratus.
abstract: 1. Monoamine oxidase (MAO) was determined fluorometrically in male goldfish tissues, and the effects of specific inhibitors determined. 2. MAO activity in kidney greater than intestine greater than pancreas greater than brain approximately liver greater than testis. Apparent Michaelis constant (Km) was higher in the first three and lower in the last three tissues. 3. Specific MAO type A inhibitors (harmaline, clorgyline) were much more effective than a type B inhibitor (deprenyl) in reducing MAO activity. 4. Apparently goldfish tissues contain only a single type A-like MAO.
mesh_terms: D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D003530:Cyprinidae / Q000378:metabolism*; D006054:Goldfish / Q000378:metabolism*; D006246:Harmaline / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D012642:Selegiline / Q000494:pharmacology
chemical_list: D012642:Selegiline; D006246:Harmaline; D008995:Monoamine Oxidase; D003010:Clorgyline