title: [The endocrine pancreas in pluriglandular neoplasia type I. A report of two cases and review of the literature].
abstract: The changes of the endocrine pancreas in two cases of pluriglandular neoplasia type I were studied. A 15 year-old girl showed an amyloid containing ductuloinsular B cell adenoma, microadenomas and nesidioblastic processes. The simultaneous presence of hyperprolactinemia and nephrolithiasis indicates the existence of the endocrine polyadenomatosis. A 33 year-old woman had four amyloid containing B cell adenomas with ductular proliferation, a main cell adenoma of the parathyroid and a prolactinoma of the adenohypophysis. Solitary or multiple ductuloinsular adenomas, amyloid of the endocrine type and nesidioblastic activity are not specific features of the endocrine pancreas in pluriglandular adenomatosis. Similar structures can be found in isolated islet cell tumors or in nesidioblastosis. Ductuloinsular proliferations can also be observed in chronic pancreatitis.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007340:Insulinoma / Q000473:pathology; D007515:Islets of Langerhans / Q000473:pathology*; D007669:Kidney Calculi / Q000473:pathology; D009377:Multiple Endocrine Neoplasia / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology; D011388:Prolactin / Q000097:blood
chemical_list: D011388:Prolactin
vernacular_title: Das endokrine Pankreas bei pluriglandulärer Neoplasie Typ I. Fallbericht und Literaturüberblick.