The effects of somatostatin, its fragments and an analog on electroconvulsive shock-induced amnesia in rats.
In the present study the effects of intracerebroventricularly [icv] administered somatostatin [linear and cyclic], somatostatin3-6, somatostatin7-10 and des AA1,2,4,5,12,13 [D-Trp8] somatostatin [ODT8-SS] were investigated on electroconvulsive shock [ECS]-induced retrograde amnesia in rats. The ECS significantly decreased the foot shock-induced avoidance latency, and thus caused retrograde amnesia. Somatostatin [linear and cyclic] in a dose of 0.6 nM had no action on the ECS-induced retrograde amnesia, while in doses of 3 nM and [cyclic only] 6 nM it significantly prevented it. Somatostatin3-6, somatostatin7-10 and ODT8-SS in doses of 0.6, 3 and 6 nM had no effect on the ECS-induced amnesia. These results indicate that the whole sequence of the original somatostatin molecule is needed to block the ECS-caused retrograde amnesia.
D000647:Amnesia / Q000503:physiopathology*; D000648:Amnesia, Retrograde / Q000503:physiopathology*; D000818:Animals; D004597:Electroshock; D006801:Humans; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D013004:Somatostatin