title: Alprazolam in clinically anxious patients with depressed mood.
abstract: A double-blind study compared alprazolam and placebo in 462 clinically anxious patients with accompanying depressed mood. Alprazolam was more effective than placebo as measured by the Hamilton Anxiety Rating Scale, the Self-Rating Symptom Scale, Target Symptoms, Physician's Global Impressions, and Patient's Global Impressions. Alprazolam was not significantly different from placebo in the number of patients reporting drowsiness, the most frequent side effect.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000525:Alprazolam; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D000525:Alprazolam