title: Regulation of cyclic nucleotides in retinal photoreceptors. An ultracytochemical approach on the role of cyclases.
abstract: The distribution of cyclases in retinal photoreceptors of dark- and light-adapted brook trout was studied by means of a cytochemical method (lead precipitation). It confirms earlier reports that retinal photoreceptors contain high levels of cyclic nucleotides, and that cAMP predominates in cones and cGMP in rods. There is an apparent difference in the level of the cyclases with the adaptive states. In addition, the catalytic unit of cyclase is interlamellar in cones. In rods, adenylate cyclase is intradiscal, while the location of guanylate cyclase varies with the adaptive state. The variation of cyclase with adaptation indicates that this enzyme has a role in the process of visual transduction.
mesh_terms: D000262:Adenylyl Cyclases / Q000502:physiology; D000818:Animals; D006162:Guanylate Cyclase / Q000502:physiology; D009712:Nucleotides, Cyclic / Q000502:physiology*; D010786:Photoreceptor Cells / Q000502:physiology*; D012160:Retina / Q000201:enzymology / Q000502:physiology*; D014337:Trout; D014785:Vision, Ocular
chemical_list: D009712:Nucleotides, Cyclic; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase