Fibrinopeptide A and sudden coronary death.
Fibrinopeptide A (FPA) concentrations were measured in blood taken by direct cardiac puncture from 31 patients who had died suddenly of ischaemic heart disease (IHD) and from 8 patients who had died suddenly of other causes. Mean FPA concentration in the IHD group was five times higher than that in the non-IHD group. This difference was almost entirely due to the high FPA level in the IHD subjects with a history of the disease. The FPA difference between the IHD and non-IHD groups is unlikely to have been due to differences in methods of resuscitation. A possible interpretation of the findings is that thrombin production causes or aggravates the course of events leading to sudden IHD death, particularly in subjects with a past history of IHD.
D000368:Aged; D003327:Coronary Disease / Q000401:mortality* / Q000628:therapy; D003645:Death, Sudden / Q000209:etiology*; D005260:Female; D005340:Fibrinogen / Q000097:blood*; D005344:Fibrinopeptide A / Q000097:blood*; D006321:Heart; D006801:Humans; D008297:Male; D008405:Massage; D008875:Middle Aged; D011677:Punctures; D012151:Resuscitation; D013917:Thrombin / Q000096:biosynthesis; D013997:Time Factors
D005344:Fibrinopeptide A; D005340:Fibrinogen; D013917:Thrombin