title: Intestinal lavage in the treatment of Crohn's disease: a pilot study.
abstract: Taking into account that a damaged mucosal barrier may be responsible for the impairment and some systemic complications in Crohn's disease, we employed intestinal lavage as a therapeutic method in six patients suffering from active Crohn's disease. The results were compared with those obtained from a control group that received similar treatment with the exception of the lavage. Intestinal lavage was carried out with 18 1 of normal saline administered via a jejunal tube over a period of 2 h. The lavage procedure was tolerated well by all patients. A significant decrease of the Crohn's disease activity index and a significantly lower hospitalization time suggest a benefit in using the lavage method. Provided that these results can be confirmed in a larger series of patients, intestinal lavage may contribute to the strategy of conservative treatment of Crohn's disease.
mesh_terms: D000863:Antacids / Q000627:therapeutic use; D003348:Cortisone / Q000627:therapeutic use; D003424:Crohn Disease / Q000628:therapy*; D004043:Dietary Fiber / Q000009:adverse effects; D005260:Female; D006801:Humans; D007583:Jejunum; D010288:Parenteral Nutrition; D012460:Sulfasalazine / Q000627:therapeutic use; D007507:Therapeutic Irrigation / Q000379:methods*
chemical_list: D000863:Antacids; D004043:Dietary Fiber; D012460:Sulfasalazine; D003348:Cortisone