title: Neuroleptic drug effect on platelet monoamine oxidase and plasma amine oxidase in schizophrenia.
abstract: Activity levels of platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) were determined in eight chronic schizophrenic patients who had been treated with neuroleptic drugs for 3 months. The mean reduction in platelet MAO activity was 18.6%. The extent of decrease was statistically significant. The reduction in enzyme activity was unrelated to serum iron levels. PAO activity was unaltered. The implications for schizophrenia research are discussed.
mesh_terms: D000328:Adult; D006631:Amine Oxidase (Copper-Containing); D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects* / Q000201:enzymology; D002746:Chlorpromazine / Q000627:therapeutic use; D005260:Female; D005476:Fluphenazine / Q000627:therapeutic use; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000097:blood*; D012559:Schizophrenia / Q000188:drug therapy* / Q000201:enzymology
chemical_list: D014150:Antipsychotic Agents; D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase; D000587:Oxidoreductases Acting on CH-NH Group Donors; D006220:Haloperidol; D005476:Fluphenazine; D002746:Chlorpromazine