Effects of synthetic rat C-peptide in normal and diabetic rats.
The effects of synthetic rat C-peptide 1 and C-peptide 2 on plasma insulin and blood glucose concentrations in the rat were studied. Infusion of rat C-peptide (500 micrograms X h-1 X kg-1) diminished glucose induced increase of plasma insulin by 56% (15.2 +/- 0.9 versus 6.6 +/- 0.6 ng/ml, p less than 0.01, mean +/- SEM). Somatostatin infused at a rate of 50 micrograms X h-1 X kg-1 body weight inhibited glucose-induced insulin secretion by 33%. In the presence of a mixture of both C-peptides or somatostatin, blood glucose after intravenous glucose was higher than in the control experiments. In alloxan-diabetic rats, C-peptide (160 micrograms/kg) significantly increased and prolonged the hypoglycaemic effect of exogenous insulin. It is suggested that C-peptide may not be a biologically inert substance.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000008:administration & dosage*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004347:Drug Interactions; D005947:Glucose / Q000008:administration & dosage; D006728:Hormones / Q000008:administration & dosage; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood*; D007329:Insulin Antagonists; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000008:administration & dosage
D001786:Blood Glucose; D002096:C-Peptide; D006728:Hormones; D007328:Insulin; D007329:Insulin Antagonists; D013004:Somatostatin; D005947:Glucose