The effect of sinusoidal vibration on the uniformity of packing of powder beds.
Sinusoidal vibration, at a number of defined sets of conditions, has been applied to packings of certain particle size fractions of lactose. The distribution of local porosity within these vibrated packings was determined using a gamma-ray attenuation technique, and could be compared with porosity data for samples not subjected to vibration. It was found that the application of vibration in a vertical mode markedly increased the uniformity of packing; horizontal vibration was less effective in this respect. The relationship between local porosity and position with a packing, observed in most non-vibrated samples, was generally absent from vibrated packings.
D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D007785:Lactose; D010316:Particle Size; D011208:Powders; D014732:Vibration
D011208:Powders; D007785:Lactose