Nature of polypeptides synthesized in influenza a virus-infected nonpermissive cells of the immune system.
Inoculation with influenza A virus of nonpermissive cells from the immune system of Wistar rats was followed by an abortive reproduction cycle accompanied by the synthesis of viral polypeptides on the background of substantially decreased total protein synthesis. The de novo synthesized proteins in virus-infected immune system cells were shown to represent at least two types of viral protein, namely the nucleocapsid (NP) and matrix (M) proteins. The ability of influenza virus to partial expression of the genome in immunocytes along with the reversible injury to the cell metabolism should be taken into account in evaluating the possible mechanisms of action of influenza A virus on the functional activity of cells of the immune system.
D000818:Animals; D002213:Capsid / Q000096:biosynthesis; D002460:Cell Line; D004285:Dogs; D006023:Glycoproteins / Q000096:biosynthesis; D009980:Influenza A virus / Q000502:physiology*; D007668:Kidney; D008214:Lymphocytes / Q000378:metabolism / Q000382:microbiology*; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology*; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology; D014763:Viral Matrix Proteins; D014764:Viral Proteins / Q000096:biosynthesis*
D006023:Glycoproteins; D014763:Viral Matrix Proteins; D014764:Viral Proteins