[Changes in the GABA-transaminase activity in various structures of the rat brain after administration of benzodiazepine tranquilizers].
Quantitative histochemistry was used to study the effects of phenazepam, medazepam, diazepam, and nitrazepam on GABA-transaminase activity in different rat brain structures. Phenazepam and diazepam, which produced anxiolytic effect in low doses, selectively inhibited GABA-transaminase of the hippocamp. The degree of GABA-transaminase inhibition corresponded with pharmacological activity of the test benzodiazepines. It is assumed that inhibition of brain GABA-transaminase by benzodiazepines is linked with their interaction with GABA-benzodiazepine receptor complex.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D002525:Cerebellar Cortex / Q000201:enzymology; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005239:Fear / Q000187:drug effects; D005625:Frontal Lobe / Q000201:enzymology; D006624:Hippocampus / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008472:Medazepam / Q000494:pharmacology; D051381:Rats; D000637:Transaminases / Q000037:antagonists & inhibitors*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D000637:Transaminases; D000612:4-Aminobutyrate Transaminase; D008472:Medazepam; D003975:Diazepam
Izmenenie aktivnosti GAMK-transaminazy v razlichnykh strukturakh mozga krys pod vliianiem trankvilizatorov benzodiazepinovogo riada.