Effects of 6-methoxytetrahydro-beta-carboline on 5-hydroxytryptamine binding in rat brain.
6-MeOTHBC competes for 5-HT binding sites in rat brain in-vitro and in-vivo. The beta-carboline is significantly more active at the type 1 [3H]-5-HT, than the type 2 [3H]spiperone receptors, in-vitro. Following injection, 6-MeOTHBC significantly decreases [3H]-5-HT binding in the cortex. The ineffectiveness on [3H]spiperone binding in-vivo corresponds with the low affinity in-vitro. The effect of 6-MeOTHBC on central 5-HT binding may be a significant aspect of its 5-HT-ergic activity.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002243:Carbolines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
D000927:Anticonvulsants; D002243:Carbolines; D007211:Indoles; D011985:Receptors, Serotonin; C002272:6-methoxytryptoline; D012701:Serotonin; D013134:Spiperone