[Age-related characteristics of potassium glutamate pharmacokinetics].
Experiments on young and old rabbits and rats were made to study the age-associated features of the pharmacokinetics of a new drug--potassium glutamate developed at the Laboratory of Experimental Pharmacology, Institute of Gerontology, Academy of Medical Sciences of the USSR. The age-associated differences in some pharmacokinetic parameters of potassium glutamate were disclosed: an increase in the half-life, a decrease in the overall clearance and a reduction in the elimination coefficient, an increase in the extent of distribution and area of the pharmacokinetic curve in old animals. A correlation was found between the pharmacokinetic parameters and drug pharmacological activity in animals of different age groups. The use of the pharmacokinetic data made it possible to calculate the optimal doses and to develop the schemes of effective application of potassium glutamate for young and old animals, as well as to extrapolate the experimental data to the drug clinical trials.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000378:metabolism / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D005971:Glutamates / Q000378:metabolism* / Q000627:therapeutic use; D018698:Glutamic Acid; D006207:Half-Life; D007700:Kinetics; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D005971:Glutamates; D018698:Glutamic Acid
Vozrastnye osobennsoti farmakokinetiki kaliia glutaminata.