title: Family history and CSF homovanillic acid pattern during neuroleptic treatment.
abstract: In 24 patients receiving neuroleptics, the 11 patients whose CSF homovanillic acid showed no tolerance to neuroleptics at 1 month had significantly more residual symptoms, extrapyramidal side effects, and history of psychiatric hospitalization in first-degree relatives.
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D011379:Prognosis; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000523:psychology
chemical_list: D014150:Antipsychotic Agents; D010648:Phenylacetates; D006719:Homovanillic Acid