Effect of beta-blocking agents on peroperative changes in serum phosphate.
Hypophosphataemia in association with surgical trauma is usually attributed to hyperalimentation with glucose solution, or of phosphaturia due to haemodilution. We have shown that it can be induced by trauma, and probably forms part of the humoral response of trauma. In experimental studies on pigs we found that the post-traumatic fall in serum phosphate is bi-phasic, and that the first phase can be prevented by beta-blocking agents. In the present study we compared the peroperative phosphate variations in 7 thyrotoxic patients undergoing elective thyroid surgery while under treatment with beta-blocking agents with those 10 patients submitted to elective surgery (5 thyroid and 5 knee operations) but not receiving beta-blocking agents. We found that the peroperative fall in serum phosphate was prevented in patients receiving beta-blocking agents. This supports the hypothesis that the rapid fall in serum phosphate in immediate association with operative trauma is mediated through the release of catecholamines.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D002118:Calcium / Q000097:blood; D004837:Epinephrine / Q000652:urine; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000601:surgery; D007432:Intraoperative Period; D007717:Knee / Q000601:surgery; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood* / Q000652:urine; D013961:Thyroid Gland / Q000601:surgery
D000319:Adrenergic beta-Antagonists; D010710:Phosphates; D008274:Magnesium; D002118:Calcium; D004837:Epinephrine