title: Bi-hemispheric CBF and its CO2 reactivity of TIAs and completed strokes in ICA occlusions.
abstract: Bi-hemispheric cerebral blood flow (CBF) measurements during rest and hyperventilation, with intra-arterial 133Xe injection method, were investigated in 19 cases, angiographically diagnosed as unilateral internal carotid artery (ICA) occlusion, including 8 cases with TIAs and 11 cases with completed strokes as the onset. Indices of cerebral vascular resistance and CO2 reactivity with decreasing arterial PCO2 were also investigated. A significant decrease (P less than 0.05) of hemispheric mean CBF was noted in the ischemic hemisphere, but normal flow values in the unaffected hemisphere and preserved CO2 responsiveness during hyperventilation were observed in both the affected and unaffected hemispheres in patients with TIAs. Moreover, a direct relationship between CBF and blood pressure, observed in 11 cases with completed strokes, was not recognized in 8 cases with TIAs. A degree of the abnormalities of the affected hemisphere in cerebral circulation was suggested to be somewhat different between TIAs and completed strokes in ICA occlusions, and bi-hemispheric CBF measurements would be an useful method for evaluating the various indices of the CBF in ICA occlusions.
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002340:Carotid Artery Diseases / Q000503:physiopathology*; D002343:Carotid Artery, Internal; D002560:Cerebrovascular Circulation; D006801:Humans; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008875:Middle Aged; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D002245:Carbon Dioxide