[Activity of various liver enzymes in rats following a flight aboard the Cosmos-936 biosatellite].
After the 18.5-day flight on board the biosatellite Cosmos-936, the activity of 6 glucocorticoid-activated enzymes in the rat liver was investigated. It was found that at R+O activities of tyrosine aminotransferase and tryptophane pyrrolase, as well as fructose-1,6-diphosphatase, glucose-6-phosphatase, aspartate aminotransferase and alanine aminotransferase increased. The two former enzymes react rapidly (within several hours) to an increase in the glucocorticoid level, whereas those latter react only to a continuous prolonged effect of glucocorticoids. These increases were paralleled by a growth in the glycogen concentration in the liver. The findings indicate that during the flight the rats underwent a chronic stress induced by weightlessness.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D014366:Tryptophan Oxygenase / Q000378:metabolism; D014444:Tyrosine Transaminase / Q000378:metabolism
D014366:Tryptophan Oxygenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D014444:Tyrosine Transaminase; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D010729:Phosphoenolpyruvate Carboxykinase (GTP)
Aktivnost' nekotorykh fermentov v pecheni krys posle poleta na biosputnike "Kosmos-936'.