title: Independent origin and modulation of vasopressin as compared to dynorphin and alpha-neo-endorphin in the medulla-pons of the rat.
abstract: Bilateral, radiofrequency destruction of the hypothalamic paraventricular nucleus resulted in a pronounced depression in levels of immunoreactive (ir-) vasopressin (VP) in the medulla-pons of rats. The contents of ir-dynorphin1-17 (DYN), ir-DYN1-8 and ir-alpha-neo-endorphin (alpha-NE) therein were not, in contrast, affected. Exposure of naive rats to acute foot-shock stress was associated with an elevation in levels of ir-VP in the medulla-pons whereas those of ir-DYN, ir-DYN1-8 and ir-alpha-NE were not significantly altered. The data indicate that the paraventricular nucleus is a major source of ir-VP but not of ir-DYN, ir-DYN1-8 or ir-alpha-NE in the medulla-pons, and that these pools of ir-VP, in contrast to those of ir-DYN, ir-DYN1-8 and ir-alpha-NE, are involved in the response to stress. It is concluded that ir-DYN, ir-DYN1-8 and ir-alpha-NE exist in (a) neuronal network(s) independent of that of ir-VP in the medulla-pons of the rat.
mesh_terms: D000818:Animals; D004399:Dynorphins; D004597:Electroshock; D004723:Endorphins / Q000096:biosynthesis*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism; D011149:Pons / Q000502:physiology*; D011498:Protein Precursors / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism; D014667:Vasopressins / Q000096:biosynthesis*
chemical_list: D004723:Endorphins; D011498:Protein Precursors; D014667:Vasopressins; C025681:alpha-neoendorphin; D004399:Dynorphins