Sensitivity to radiations of Mg2+ and (Ca2+ + Mg2+) ATPase activities associated with erythrocyte membrane fragments.
Treatment of disrupted erythrocyte membranes with ionizing radiation induces a partial oxidation of -SH groups (as expected from reported data) and a loss of membrane phospholipids as confirmed by the decrease of membrane amino groups. The resulting disturbance of the membrane assembly strongly affects the membrane bound divalent cation-dependent ATPase activities, possibly by causing the formation of a dead-end enzyme complex unable to complete the ATP splitting cycle.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000528:radiation effects*; D004912:Erythrocytes / Q000528:radiation effects*; D006801:Humans; D010084:Oxidation-Reduction
D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases