title: Basic understanding of the electrophysiologic actions of antiarrhythmic drugs. Sources, sinks, and matrices of information.
abstract: The author creates an intellectual framework consisting of key electrophysiologic principles, basic mechanisms of arrhythmogenesis, and important drug reactions that will allow the rational use of antiarrhythmic drugs. Basic principles have been emphasized because current understanding requires it.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001950:Bretylium Tosylate / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects; D004071:Digitalis Glycosides / Q000494:pharmacology; D004594:Electrophysiology; D006329:Heart Conduction System / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D008563:Membrane Lipids / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D013565:Sympatholytics / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D004071:Digitalis Glycosides; D007473:Ion Channels; D008563:Membrane Lipids; D013565:Sympatholytics; D001950:Bretylium Tosylate; D012964:Sodium