Haemodynamic effects of alpha-receptor blockade during acute administration and chronic treatment.
Acute administration of relatively large doses of the postsynaptic alpha-adrenoceptor blocking agent prazosin results in a marked vasodilatation and blood-pressure reduction, often combined with tachycardia. Chronic administration results in a decrease in total peripheral resistance and blood pressure at rest and during exercise. Cardiac output is unchanged at rest but shows a slight increase during exercise. Peripheral blood flow is increased during chronic treatment. It is concluded that alpha-receptor antagonists may be able to normalize - completely or partly - the pathological haemodynamics of the hypertensive patient.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D011224:Prazosin / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D011224:Prazosin