Experimental verification of Marr-Albus' plasticity assumption for the cerebellum.
Marr-Albus model of the cerebellum is based on the assumption that parallel fiber-Purkinje cell synapses are plastically modifiable under influences of conjunctive activation of a climbing fiber and a mossy fiber on the same Purkinje cell. This article introduces a positive support for this assumption derived from the recent experiment by Ito. Sakurai and Tongroach on rabbit flocculus. Possible reasons why the experimental verification of Marr-Albus' assumption has been so difficult are considered, and applicability of Marr-Albus model of the cerebellum to problems of motor learning is discussed.
D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D004558:Electric Stimulation; D005133:Eye Movements; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006801:Humans; D008959:Models, Neurological; D009043:Motor Activity; D009473:Neuronal Plasticity; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology; D012018:Reflex
D005971:Glutamates; D018698:Glutamic Acid