Inhibition of the active transport of D-glucose and L-tyrosine by DDT and DDE in the rat small intestine.
1. The effect of DDT and DDE on the active transport of D-glucose and L-tyrosine was studied in everted sacs of small intestine. 2. DDT and DDE (10(-5) and 10(-4) M) inhibit the active transport of D-glucose and L-tyrosine. 3. These organochlorine compounds also inhibit the (Na+ + K+)-ATPase from the same tissue, to about the same extent. 4. These results suggest that the inhibition of the active transport is due to an action of DDT and DDE on the sodium pump.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D003634:DDT / Q000494:pharmacology*; D003633:Dichlorodiphenyl Dichloroethylene / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism*
D014443:Tyrosine; D003633:Dichlorodiphenyl Dichloroethylene; D003634:DDT; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose