In-vivo and in-vitro assessment of chloroquine-resistant Plasmodium falciparum malaria in Zanzibar.
A population-based field study was conducted in Zanzibar Town, Zanzibar, Tanzania, to assess the in-vivo and in-vitro susceptibility to chloroquine of Plasmodium falciparum. Single-dose therapy with chloroquine (10 mg base/kg) failed to clear parasitaemia in 11 of 22 (50%) treated subjects, and a standard therapeutic regimen of chloroquine (25 mg base/kg) failed to clear parasitaemia in 11 of 32 (34%) treated subjects. Concurrent in-vitro testing by the Rieckmann micromethod showed that 8 of 12 (66%) isolates were chloroquine-resistant.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy; D010963:Plasmodium falciparum / Q000187:drug effects*; D013636:Tanzania
D002738:Chloroquine