Carbon dioxide response curves following midazolam and diazepam.
The ventilatory response to carbon dioxide was measured in volunteers before, and at intervals after the i.v. administration of midazolam 0.075 mg kg-1 and diazepam 0.15 mg kg-1. In the doses used neither drug caused any statistically significant respiratory depression and there were no differences between the drugs.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D002245:Carbon Dioxide; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008874:Midazolam; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D002245:Carbon Dioxide; D003975:Diazepam; D008874:Midazolam