title: Regulation of amidase formation in mutants from Pseudomonas aeruginosa PAO lacking glutamine synthetase activity.
abstract: The formation of amidase was studied in mutants from Pseudomonas aeruginosa PAO lacking glutamine synthetase activity. It appeared that catabolite repression of amidase synthesis by succinate was partially relieved when cellular growth was limited by glutamine. Under these conditions, a correlation between amidase and urease formation was observed. The results suggest that amidase formation in strain PAO is subject to nitrogen control and that glutamine or some compound derived from it mediates the nitrogen repression of amidase.
mesh_terms: D000581:Amidohydrolases / Q000096:biosynthesis*; D004794:Enzyme Repression; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism*; D005973:Glutamine / Q000494:pharmacology; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000201:enzymology* / Q000235:genetics; D013386:Succinates / Q000494:pharmacology; D019802:Succinic Acid
chemical_list: D013386:Succinates; D005973:Glutamine; D019802:Succinic Acid; D000581:Amidohydrolases; C019665:amidase; D005974:Glutamate-Ammonia Ligase