[Neuroleptics as antagonists of gamma-aminobutyric acid].
Experiments on the neurons of isolated spinal cord of rats aged 9-14 days have revealed that like picrotoxin, the neuroleptics reduce the GABA-induced depolarization of primary afferents, hyperpolarization of the motoneurons and inhibition of the function of the interneurons which exercise the inhibitory control of motoneuronal activity. The highest GABA-lytic activity was displayed by the butirophenon derivatives (droperidol and haloperidol). Triphthazin slightly yields to these drugs as regards the activity. Aminazin and levomepromazin have a moderate GABA-lytic activity, whereas thioridazin and ftorphenazin have none. A possible role of the GABA-lytic activity of the neuroleptics in their antipsychotic action is discussed.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D018756:GABA Antagonists; D066298:In Vitro Techniques; D009046:Motor Neurons / Q000187:drug effects; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D013126:Spinal Nerve Roots / Q000187:drug effects
D014150:Antipsychotic Agents; D018756:GABA Antagonists; D010852:Picrotoxin
Neĭroleptiki kak antagonisty gamma-aminomaslianoĭ kisloty.