Possible prostaglandin-mediated effect of diethylcarbamazine on rat uterine contractility.
The effect of diethylcarbamazine pretreatment on uterine contractility was investigated in both pregnant and nonpregnant rats. The pretreatment potentiated the uterine responses to oxytocin and acetylcholine, and enhanced the spontaneous uterine contraction of rats in oestrus or 17-20 days pregnant. This enhanced contraction was antagonized both in-vivo and in-vitro by indomethacin, suggesting the involvement of prostaglandins.
D000818:Animals; D004049:Diethylcarbamazine / Q000494:pharmacology*; D004971:Estrus; D005260:Female; D009126:Muscle Relaxation / Q000187:drug effects; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D011453:Prostaglandins; D004049:Diethylcarbamazine