title: Dopaminergic agonists: comparative actions of amine and sulfonium analogues of dopamine.
abstract: We have investigated the possibility that structural modifications of the sulfonium analogue of dopamine (4) would produce the same pattern of biological activity as structural modifications of dopamine. A series of methyl- tetralinyl -, and naphthalenylsulfonium analogues 5-7 were prepared and tested for their ability to inhibit the potassium-evoked release of [3H]acetylcholine from striatal slices. All compounds were tested under normal conditions and after depletion of dopamine stores with reserpine and alpha-methyl-p-tyrosine. The amine and sulfonium analogues 2-6 all showed direct agonist activity. The sulfonium analogue 7 produced, predominantly, indirect activity. In contrast to the amine analogues, chemical modifications of the sulfonium compounds produced little change in their dopamine agonist activity.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D011188:Potassium / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013452:Sulfonium Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors; D019805:alpha-Methyltyrosine
chemical_list: D000588:Amines; D007202:Indicators and Reagents; D008781:Methyltyrosines; D013452:Sulfonium Compounds; D019805:alpha-Methyltyrosine; D012110:Reserpine; D014446:Tyrosine 3-Monooxygenase; D000109:Acetylcholine; D011188:Potassium; D004298:Dopamine