2-Propanol treatment induces selectively the metabolism of carbon tetrachloride to phosgene. Implications for carbon tetrachloride hepatotoxicity.
D000433:1-Propanol / Q000494:pharmacology*; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002245:Carbon Dioxide / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D002725:Chloroform / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004357:Drug Synergism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D010705:Phosgene / Q000378:metabolism*; D051381:Rats
D010705:Phosgene; D002245:Carbon Dioxide; D002248:Carbon Monoxide; D002725:Chloroform; D003577:Cytochrome P-450 Enzyme System; D000433:1-Propanol; D002251:Carbon Tetrachloride; D010634:Phenobarbital