Analgesic actions of mu- and kappa-opiate agonists in rats.
The antinociceptive profiles of mu- and kappa-opiate agonists were determined in a combined tail immersion plus tail pressure nociceptive test in rats. Combined analysis of potencies for pressure against heat noxia enabled differentiation between all mu- and kappa-agonists tested, thus confirming previous studies in other animal species and paralleling observations from studies on isolated tissue preparations. The distinct antinociceptive profiles produced by mu- and kappa-agonists provide further quantitative evidence that these agents are behaviourally different.
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D003496:Cyclazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016314:Ethylketocyclazocine / Q000031:analogs & derivatives*; D006358:Hot Temperature; D008297:Male; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu
D000701:Analgesics, Opioid; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D016314:Ethylketocyclazocine; C012395:ketazocine; D003496:Cyclazocine