Impaired TSH response to TRH after intravenous ranitidine in man.
Ranitidine, given by i.v. infusion, decreased TSH response to TRH in 7 subjects. This effect, completely different from that obtained with cimetidine, suggests that the action of ranitidine is likely to be independent of H2-receptor blockade and rather may be related to the cholinergic-like effect of this drug.
D000328:Adult; D005663:Furans / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011899:Ranitidine; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D005663:Furans; D006635:Histamine H2 Antagonists; D013973:Thyrotropin-Releasing Hormone; D011899:Ranitidine; D013972:Thyrotropin