Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis.
The peripheral venous plasma levels of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were determined by radioimmunoassay in 23 control subjects, 14 patients with essential hypertension, 19 patients with cerebrovascular disease (CVD) not taking aspirin, 12 patients with DVD taking aspirin, and 12 patients with Takayasu's arteritis. There was no significant difference in 6-keto-PGF1 alpha levels between the control subjects and hypertensive patients. In CVD patients and patients with Takayasu's arteritis, the plasma 6-keto-PGF1 alpha levels were significantly lower than those in control subjects. The internal jugular venous and femoral arterial plasma levels of 6-keto-PGF1 alpha and thromboxane B2 (TxB2) were measured in 10 CVD patients not taking aspirin. The patients with occlusive lesions of major arteries exhibited higher TxB2/6-keto-PGF1 alpha ratios in the internal jugular venous plasma.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001015:Aortic Arch Syndromes / Q000097:blood*; D001167:Arteritis / Q000097:blood; D001241:Aspirin / Q000627:therapeutic use; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005263:Femoral Artery / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007601:Jugular Veins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011460:Prostaglandins F / Q000097:blood*; D011863:Radioimmunoassay; D013625:Takayasu Arteritis / Q000097:blood*; D013929:Thromboxane B2
D011460:Prostaglandins F; D013929:Thromboxane B2; D001241:Aspirin; C100006:prostaglandin F1