Effect of drugs on brain acetylcholine level in Gerbillus pyramidum.
1. The quantitative estimation of total acetylcholine content in the whole brain tissue in normal Egyptian gerbil Gerbillus pyramidum, gives an average of 1.43 +/- 0.06 micrograms of acetylcholine chloride/g fresh brain tissue. 2. The brain acetylcholine level in Gerbillus pyramidum was generally found to vary with the changes induced in the brain activity by drugs. 3. Depressants caused a increase and convulsants a decrease in total brain acetylcholine level. 4. Phenytoin depressed the brain activity but lowered brain acetylcholine level.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005849:Gerbillinae; D008297:Male; D008620:Meprobamate / Q000494:pharmacology; D008694:Methamphetamine / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology
D008694:Methamphetamine; D010672:Phenytoin; D009020:Morphine; D012110:Reserpine; D008620:Meprobamate; D010424:Pentobarbital; D000109:Acetylcholine; D010634:Phenobarbital