Effect of silver on sodium transport across toad skin.
Silver attenuated the insulin-induced short-circuit current and transmural potential difference. Silver diminished the ethacrynic acid-induced short-circuit current and transmural potential difference. Ouabain inhibited short-circuit current and transmural potential difference, equivalently, whether silver was present or not. The low concentration silver-induced short-circuit current is carried by a net active sodium transfer from the outside to the inside bathing solution.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002024:Bufo marinus; D004976:Ethacrynic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D010042:Ouabain / Q000494:pharmacology; D012834:Silver / Q000494:pharmacology*; D012867:Skin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D007328:Insulin; D012834:Silver; D010042:Ouabain; D012964:Sodium; D004976:Ethacrynic Acid