[Trial of using neurotropic preparations (difenin and pyrroxan) for the purpose of prophylactic anticrisis treatment of hypertension].
A preventive effect of diphenylhydantoin and pyrroxan was studied in 35 hypertensive patients with frequent hypertensive crises. A course application of placebo served as a control. There were determined critical and neurophysiological (bioelectrical) changes before and after treatment. Determination of bioelectrical changes was conducted using the BFA EEG (qualitative, visual description of frequency and their quantitative values). Diphenylhydantoin and pyrroxan were found to prevent the development of hypertensive crises and improve cerebral bioelectrical parameters in most of patients.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D002986:Clinical Trials as Topic; D004146:Dioxanes / Q000627:therapeutic use*; D004147:Dioxins / Q000627:therapeutic use*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use*; D010919:Placebos
D000317:Adrenergic alpha-Antagonists; D000927:Anticonvulsants; D000959:Antihypertensive Agents; D004146:Dioxanes; D004147:Dioxins; D010919:Placebos; D010672:Phenytoin; C009143:proroxan
Opyt primeneniia neĭrotropnykh preparatov (difenina i pirroksana) s tsel'iu profilakticheskogo protivokrizovogo lecheniia bol'nykh gipertonicheskoĭ bolezn'iu.