Brain abscess due to penicillin- and clindamycin-resistant Bacteroides melaninogenicus.
The case of a patient with severe anaerobic infection, a brain abscess, is presented. The causative organism was a penicillinase-producing, clindamycin-resistant strain of Bacteroides melaninogenicus. Treatment with adequate doses of penicillin G failed. Findings in this case suggest caution when basing therapy on the untested assumption that B. melaninogenicus is routinely susceptible to penicillin and clindamycin therapy.
D000328:Adult; D001442:Bacteroides Infections / Q000150:complications* / Q000188:drug therapy; D001922:Brain Abscess / Q000188:drug therapy / Q000209:etiology*; D002981:Clindamycin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use; D001443:Prevotella melaninogenica / Q000187:drug effects
D010406:Penicillins; D002981:Clindamycin