Differentiation of human T lymphocytes: II. Phenotypic difference in skin and blood malignant T-cells in cutaneous T-cell lymphoma.
The cell surface antigen phenotype of circulating and skin malignant T-cells in patients with cutaneous T-cell lymphoma were studied. The mature T-cell antigen phenotype of the malignant T-cells was identical for circulating and skin malignant T-cells. In contrast, skin malignant T-cells expressed the immature human T-cell antigen Thy-1, surface membrane transferrin receptors, and Ia-like determinants while circulating malignant T-cells did not express these antigens. Skin infiltrating T-cells in benign dermatoses also expressed Thy-1 and Ia-like determinants. These observations support the notion that the skin is a major site of extrathymic T-cell differentiation and may promote phenotypic changes in circulating T-cells that home to skin.
D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis*; D006023:Glycoproteins / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000032:analysis; D009182:Mycosis Fungoides / Q000276:immunology; D010641:Phenotype; D011956:Receptors, Cell Surface / Q000032:analysis; D011990:Receptors, Transferrin; D012751:Sezary Syndrome / Q000276:immunology*; D012867:Skin / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018800:Thy-1 Antigens
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D006023:Glycoproteins; D000949:Histocompatibility Antigens Class II; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D018800:Thy-1 Antigens; C028388:thymus-leukemia antigens