title: [Effect of neurotransmitters and psychotropic drugs on the immune system. Mediator role of hormones and clinical implications].
abstract: Neurotransmitters and psychotropic drugs may affect the immune system by direct action on immunocompetent cells or indirectly via hormonal secretions induced by these drugs. The effect of centrally acting drugs (lithium, antipsychotic, antiepileptic, hypotensive and opioid agents) on the immune system is reviewed and the mediator role of hormonal changes is assessed. Clinical implications resulting from these immune modulations are analyzed within the framework of autoimmune, allergic, infectious and neoplastic diseases.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001327:Autoimmune Diseases / Q000188:drug therapy; D001921:Brain / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D014150:Antipsychotic Agents; D002395:Catecholamines; D006728:Hormones; D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs; D005680:gamma-Aminobutyric Acid; D008094:Lithium; D000109:Acetylcholine; D004298:Dopamine
vernacular_title: Action des neurotransmetteurs et des médicaments psychotropes sur le système immunitaire. Rôle médiateur des hormones et implications cliniques.