The pathogenesis of hepatitis in alcohol abuse and jejunoileal bypass.
Acetaldehyde, produced in excessive amounts in alcohol abuse or after jejunoileal bypass, binds to hepatocyte plasma membranes by way of formation of an intermediate Schiff's base. This binding has no effect on cellular metabolism or membrane function but causes physical changes in membrane properties which activate the complement cascade and this results in hepatocellular damage.
D000079:Acetaldehyde / Q000096:biosynthesis* / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D003167:Complement Activation; D004910:Erythrocyte Membrane / Q000276:immunology; D000431:Ethanol / Q000009:adverse effects / Q000378:metabolism; D005260:Female; D006505:Hepatitis / Q000209:etiology*; D006519:Hepatitis, Alcoholic / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007422:Intestines / Q000382:microbiology; D007583:Jejunum / Q000601:surgery*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D011183:Postoperative Complications
D000431:Ethanol; D000079:Acetaldehyde