title: Early morning insomnia with rapidly eliminated benzodiazepines.
abstract: Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.
mesh_terms: D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D005479:Flurazepam / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D008874:Midazolam; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy / Q000209:etiology*; D014229:Triazolam / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D014229:Triazolam; D005479:Flurazepam; C025130:quazepam; D008874:Midazolam