On the use of clonidine and thioproperazine in a woman with Gilles de la Tourette's disease.
A 25-year-old woman with Gilles de la Tourette's disease was successfully treated with clonidine (an inhibitor of noradrenaline release). However, the drug was stopped because of side effects. Thioproperazine, a phenothiazine derivative which blocks subcortical dopaminergic receptors, suppressed Gilles de la Tourette's symptoms totally. The patient has tolerated the drug well for over a year since its introduction. The pharmacomanometric investigation performed in this patient showed hyperactivity of her noradrenergic system.
D000328:Adult; D003000:Clonidine / Q000627:therapeutic use*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D010640:Phenothiazines / Q000627:therapeutic use*; D011941:Receptors, Adrenergic / Q000187:drug effects; D005879:Tourette Syndrome / Q000175:diagnosis / Q000188:drug therapy*
D010640:Phenothiazines; D011941:Receptors, Adrenergic; D003000:Clonidine