Captopril combined with minoxidil, beta-blocker and furosemide in the treatment of refractory hypertension.
14 patients with refractory hypertension did not respond either to captopril, an angiotensin II converting enzyme inhibitor, combined with a diuretic, a beta-blocker and hydralazine or minoxidil, a potent vasodilator, but they did respond to the combination of captopril, minoxidil, furosemide and a beta-blocker. There were no disturbing side effects from this combination. There may be a synergistic effect between captopril and minoxidil in the treatment of refractory hypertension. The combination is an interesting and novel method of treating patients with refractory hypertension.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000627:therapeutic use*; D011392:Proline / Q000031:analogs & derivatives*; D011743:Pyrimidines / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D011743:Pyrimidines; D008914:Minoxidil; D005665:Furosemide; D011392:Proline; D002216:Captopril; D003404:Creatinine