Ethanol sensitivity and membrane lipid composition in three strains of mouse.
Strains of mouse (Swiss OF 1, DBA/2J Ico and C57 BL/6J Ico) with different sensitivities to the hypnotic effects of acute ethanol administration were also found to have differences in fatty acid composition in synaptosomal and erythrocyte membrane phospholipids. Chronic ethanol treatment altered membrane fatty acid composition in quantitatively different ways depending on whether the mice developed tolerance (DBA, C57) or not (Swiss). These results support the hypothesis that membrane lipid composition plays a role in the sensitivity to the effects of ethanol.
D000818:Animals; D004361:Drug Tolerance; D004910:Erythrocyte Membrane / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010743:Phospholipids / Q000378:metabolism; D012890:Sleep / Q000187:drug effects; D013045:Species Specificity; D013574:Synaptosomes / Q000378:metabolism
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D000431:Ethanol