Naloxone reserves the inhibitory effects of dynorphin A on motor activity in the mouse.
Dynorphin-(1-17) (dynorphin A) significantly reduced the linear locomotion, rearing and grooming behaviors in mice using a newly devised multi-dimensional behavioral analyser. The behaviors inhibited by dynorphin A were dose-dependently antagonized by prior treatment with naloxone. The results suggest that dynorphin A-induced behavioral depression is mediated via opioid receptors in the mouse brain.
D000818:Animals; D004399:Dynorphins; D004723:Endorphins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects; D013997:Time Factors
D004723:Endorphins; D010446:Peptide Fragments; D011957:Receptors, Opioid; D009270:Naloxone; D004399:Dynorphins