title: Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.
abstract: The plasma membranes of hamster, mouse, and human tumor cell lines that display multiple resistance to drugs were examined by gel electrophoresis and immunoblotting. In every case, increased expression of a 170,000-dalton surface antigen was found to be correlated with multidrug resistance. This membrane component is of identical molecular size and shares some immunogenic homology with the previously characterized P-glycoprotein of colchicine-resistant Chinese hamster ovary cells. This finding may have application to cancer therapy.
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D002460:Cell Line; D002463:Cell Membrane Permeability; D004351:Drug Resistance; D006023:Glycoproteins / Q000276:immunology / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D008970:Molecular Weight
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D006023:Glycoproteins; D008565:Membrane Proteins