Intra-abdominal carcinomatosis after prophylactic oophorectomy in ovarian-cancer-prone families.
Prophylactic oophorectomy was performed in 28 female members of 16 families at high risk of ovarian carcinoma. 3 of these women subsequently developed disseminated intra-abdominal malignancy; there was uncertainty about the primary site despite extensive investigation. These tumours were indistinguishable histopathologically from ovarian carcinoma. It would seem that in cancer-prone families the susceptible tissue is not limited to the ovary, but includes other derivatives of the coelomic epithelium, from which primary peritoneal neoplasms may arise.
D000008:Abdominal Neoplasms / Q000209:etiology*; D000231:Adenocarcinoma, Papillary / Q000209:etiology / Q000473:pathology; D000328:Adult; D002277:Carcinoma / Q000209:etiology*; D002369:Castration / Q000009:adverse effects* / Q000379:methods; D003537:Cystadenoma / Q000209:etiology / Q000473:pathology; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000517:prevention & control; D010375:Pedigree; D012306:Risk; D013997:Time Factors