Evaluation of phenoxetol-chlorhexidine cream as a prophylactic antibacterial agent in burns.
A controlled clinical trial was conducted to compare the value of a cream containing 2% phenoxetol and 0.2% chlorhexidine as a prophylactic agent against wound infection in patients with burns affecting up to 15% total body surface area. The acquisition of bacteria was similar in the two treatment groups but the incidence of Staphylococcus aureus in the burns treated with phenoxetol-chlorhexidine cream significantly lower. The incidence of gram-negative bacilli was low in the two treatment groups, and no wound yielded Pseudomonas aeruginosa. Unlike preparations containing silver, phenoxetol-chlorhexidine does not cause electrolyte imbalance or stain materials with which it comes into contact, and it did not produce adverse effects during this trial.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002056:Burns / Q000150:complications* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005026:Ethylene Glycols / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014946:Wound Infection / Q000517:prevention & control*
D005026:Ethylene Glycols; C005398:phenoxyethanol; D002710:Chlorhexidine