A new mathematical approach to describe transmural gastric potential difference changes (great moments in pharmacodynamics).
The time moments of a gastric potential difference (PD) vs. time curve may be used to determine its time characteristics (mean time, and variance around the mean time). In addition, the PD moments determine its PD characteristics (mean PD, and variance around the mean PD). Such characteristics are useful in comparing the irritation on the gastric mucosa caused by different drugs and dosages and in evaluating the histamine blocking effect of compounds.
D000082:Acetaminophen / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D013806:Theophylline / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D000082:Acetaminophen; D000431:Ethanol; D013806:Theophylline; D001241:Aspirin