Effect of stimulation or inhibition of muscarinic or nicotinic receptors on the content of biogenic amines in various parts of rat brain.
For studying the interactions of the cholinergic and noradrenergic systems in the central nervous system rats were given muscarine or nicotine and the peripheral receptors were blocked with atropine or pempidine. After killing the animals the level of biogenic amines was determined in various parts of the brain. Evident changes were found in the levels of biogenic amines after stimulation or blockade of muscarinic or nicotinic receptors.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D004347:Drug Interactions; D008297:Male; D009116:Muscarine / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009538:Nicotine / Q000494:pharmacology; D010393:Pempidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism
D018377:Neurotransmitter Agents; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D009538:Nicotine; D001285:Atropine; D009116:Muscarine; D010393:Pempidine