A study of the atropine-resistant component of the neurogenic response of the rabbit urinary bladder.
Rabbit bladder body was stimulated to contract by a number of agonists, of which bradykinin was the most potent, and ATP one of the least potent substances tested. The atropine-resistant component of the neurogenic response was unaffected by 2 X 10(-5) M chlorpheniramine or 10(-6) M methysergide, doses which suppressed responses to histamine or 5HT. Indomethacin 10(-5) M, or 10(-5) M capsaicin both reduced the atropine-resistant component. Following treatment with 10(-6) M atropine and 10(-5) M prazosin, 10(-4) M ANAPP3 produced a further suppression of the response, but did not antagonize the response to ATP. In the bladder body, the transmitter(s) responsible for the neurogenic response may be acetylcholine and prostaglandins and possibly ATP and substance P.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002211:Capsaicin / Q000494:pharmacology; D002744:Chlorpheniramine / Q000494:pharmacology; D004351:Drug Resistance; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000502:physiology*; D011817:Rabbits; D001743:Urinary Bladder / Q000187:drug effects* / Q000294:innervation
D018377:Neurotransmitter Agents; D002744:Chlorpheniramine; D001285:Atropine; D002211:Capsaicin; D007213:Indomethacin; D008784:Methysergide