title: Intestinal uptake of fatty acids and cholesterol in four animals species and man: role of unstirred water layer and bile salt micelle.
abstract: The uptake (Jd) of fatty acids (FA), fatty alcohols (Alc) and cholesterol (C) into the jejunum of rats (R, Rattus norvegicus), rabbits (RAB, Oryctolagus cuniculus), guinea pigs (GB, Cavia porcellus), and hamsters (H, Mesocricetus auratus) was assessed in vitro. Using jejunal discs the Jd of Alc was H greater than R = GP greater than RAB, the Jd of FA was H-RAB greater than R greater than GP, but the Jd of C was R greater than H greater than RAB greater than GP. The Jd of FA was quantitatively and qualitatively different when using jejunal biopsies; in man the Jd of FA into biopsies was greater than in the other animal species, but there was no difference in Jd of FA into normal human jejunal biopsies and those showing severe abnormalities in villus architecture. There are marked species differences in the passive permeability properties of the jejunum and in the effective resistance of the overlying unstirred water layer, but these differences do not explain the species variations in the uptake of cholesterol.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D002463:Cell Membrane Permeability; D002784:Cholesterol / Q000378:metabolism*; D006224:Cricetinae; D005227:Fatty Acids / Q000378:metabolism*; D005233:Fatty Alcohols / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007583:Jejunum / Q000378:metabolism*; D008051:Lipid Bilayers; D008297:Male; D008647:Mesocricetus; D008823:Micelles; D008875:Middle Aged; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014867:Water
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D005233:Fatty Alcohols; D008051:Lipid Bilayers; D008823:Micelles; D014867:Water; D002784:Cholesterol