Narcolepsy, paranoid psychosis, major depression, and tardive dyskinesia.
This report describes a man with narcolepsy, paranoid psychosis, major depression, and tardive dyskinesia. The case illustrates the treatment difficulties such a patient presents and also raises questions about interactions between the putative neurotransmitters involved in each of these conditions. It is suggested that the presence of narcolepsy may facilitate the appearance of unwanted effects of antidepressants and neuroleptics such as psychosis and depression.
D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003866:Depressive Disorder / Q000139:chemically induced* / Q000628:therapy; D003913:Dextroamphetamine / Q000009:adverse effects; D004409:Dyskinesia, Drug-Induced / Q000150:complications / Q000209:etiology*; D004565:Electroconvulsive Therapy; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D008297:Male; D009290:Narcolepsy / Q000188:drug therapy*; D010259:Paranoid Disorders / Q000139:chemically induced*
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D006220:Haloperidol; D003913:Dextroamphetamine