[Genetic differences in the excretion of phenazepam-14C].
Content of 14C-phenazepame and its metabolites was studied in feces and urine of mice strains C57BL/6 and BALB/ c after intraperitoneal administration of the preparation at a dose of 14 mg/kg. Concentration of phenazepame and of its trihydroderivative was higher in urine of the BALB/c strain mice than in C57BL/6 strain that corresponded to genetic differences of the tranquilizer metabolism in the animal strains studied.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000652:urine*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000652:urine*; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002250:Carbon Radioisotopes; D001569:Benzodiazepines; C017928:phenazepam
Izuchenie geneticheskikh razlichiĭ v vyvedenii fenezepama-14C.