[Glutamate and GABA concentration in the brain and cerebrospinal fluid of rats treated with phosphatidylcholine].
Phosphatidylcholine increases CNS concentrations of acetylcholine. In rats we investigated whether or not phosphatidylcholine also influences the neurotransmitters glutamate and GABA. In 17 rats 1.5 gram/kg Lethicon perorally was administered daily for 2 weeks, 15 rats served as controls. In tissue from frontal cortex, striatum, substantia nigra, cerebellar cortex no significant differences between treated and untreated animals were found in glutamate or GABA concentrations. A central nervous interaction between the cholinergic system and the neurotransmitters glutamate and GABA, therefore, could not be demonstrated after 2 weeks of phosphatidylcholine intake.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002525:Cerebellar Cortex / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D008297:Male; D009115:Muridae; D010713:Phosphatidylcholines / Q000494:pharmacology*; D013378:Substantia Nigra / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D010713:Phosphatidylcholines; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid
Glutamat- und GABA-Konzentration in Gehirn und Liquor Cerebrospinalis von Ratten unter Behandlung mit Phosphatidylcholin.