[Induction of liver microsomal enzymes in epileptics under treatment with carbamazepine].
Serum gamma-GT activity was significantly (0.01 greater than P greater than 0.001) elevated in 18 out of 30 epileptics receiving carbamazepine (CBZ), i.e. in 60%. The incidence of abnormal gamma-GT levels in the control group (25 neurotic patients taking minor tranquilizers) was lower (12%). The possible relationships between the enzyme induction or chronic hepatic toxicity and the elevation of serum gamma-GT activity in epileptics taking CBZ are discussed.
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002220:Carbamazepine / Q000627:therapeutic use*; D004790:Enzyme Induction; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000201:enzymology; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000097:blood
D002220:Carbamazepine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase
Induzione degli enzimi microsomiali epatici in epilettici in trattamento con carbamazepina.