Preferential glutamine uptake by cochlear hair cells: implications for the afferent cochlear transmitter.
The cochlear uptake of amino acids which are putative neurotransmitters, or closely-related compounds, was examined autoradiographically in the gerbil. Hair cells showed no preferential uptake of most compounds tested. However, preferential accumulation of glutamine by cochlear hair cells was striking. Vestibular hair cells showed no affinity for this amino acid. Glutamine uptake by cochlear hair cells may play an important role in afferent synaptic transmission, by providing transmitter precursor and/or by clearing the synaptic cleft.
D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D003051:Cochlea / Q000502:physiology*; D005849:Gerbillinae; D005973:Glutamine / Q000378:metabolism*; D006198:Hair Cells, Auditory / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D014316:Tritium
D018377:Neurotransmitter Agents; D005973:Glutamine; D014316:Tritium