[Effect of hypotensive preparations on humoral factors in blood circulation regulation].
A total of 178 patients with labile arterial hypertension were examined for the effect of propranolol and clonidine on the central hemodynamics, plasma renin, dopamine- beta-hydroxylase, urine kallikrein, and blood prekallikrein and kallikrein. The results suggest that basic to changes in the hemodynamics produced by a single administration of propranolol is its beta-adrenoblocking effect proper. The decrease in the general peripheral resistance due to prolonged propranolol therapy may be determined by activation of the blood kallikrein-kinin system and enhancement of the descending inhibition of the sympathetic nervous system because of activation of the central alpha-adrenoreceptors under long-term blockade of beta-adrenoreceptors of the central nervous system. The changes in the hemodynamics produced by low doses of clonidine may be accounted for by its central alpha-adrenomimetic effect.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001775:Blood Circulation / Q000187:drug effects*; D003000:Clonidine / Q000627:therapeutic use; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000502:physiology*; D011433:Propranolol / Q000627:therapeutic use; D013997:Time Factors
D000959:Antihypertensive Agents; D018377:Neurotransmitter Agents; D011433:Propranolol; D003000:Clonidine
Vliianie gipotenzivnykh preparatov na gumoral'nye faktory reguliatsii krovoobrashcheniia.