The complete amino-acid sequence of anglerfish somatostatin-28 II. A new octacosapeptide containing the (Tyr7, Gly10) derivative of somatostatin-14 I.
A new somatostatin-28 has been isolated from the Teleostean fish (Lophius piscatorius) Brockmann organs. Determination of its aminoacid sequence indicates that it corresponds to an octacosapeptide containing in its C-terminal end the Tyr-7 Gly-10 derivative of somatostatin-14 I. This structure is in agreement with the one predicted by Hobart et al. (Nature (1980) 288, 137-141) from a cDNA nucleotide sequence. It demonstrates that, since the corresponding somatostatin-14 II cannot be detected in this organ, S-28 II is a terminal product of prosomatostatin II processing in anglerfish pancreatic islets.
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005399:Fishes; D007515:Islets of Langerhans / Q000032:analysis; D011498:Protein Precursors / Q000302:isolation & purification*; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000302:isolation & purification; D053561:Somatostatin-28 / Q000031:analogs & derivatives
D011498:Protein Precursors; D013004:Somatostatin; D053561:Somatostatin-28; C043024:somatostatin 14, Tyr(7)-Gly(10)-; C043025:somatostatin 28, Tyr(7)-Gly(10)-