Synthesis and pharmacological activity of benzo[b]thiophene-3-carboxylic acid derivatives.
Several dialkylaminoethyl benzo[b]thiophene-3-carboxylates, N-(2-dialkylaminoethyl)benzo[b]thiophene-3-carboxamides, 2-dialkylaminoethyl benzo[b]thiophene-3-carbamates, and substituted ureas with benzo[b]thiophene moiety, were prepared and tested for local anesthetic, anticholinergic, and antihistaminic activities. Several of the compounds showed significant activity.
D000779:Anesthetics, Local / Q000138:chemical synthesis*; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003315:Cornea / Q000187:drug effects; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis*; D011817:Rabbits; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000779:Anesthetics, Local; D006634:Histamine H1 Antagonists; D010276:Parasympatholytics; D013876:Thiophenes