Rate of formation of hydrogen peroxide (H2O2) in IUD-fitted human endometrium--a preliminary report.
Endometrial biopsy samples of (i) women (20-40 yr) using no contraceptive methods and (ii) women (25-45 yr) fitted with intrauterine contraceptive devices (CuT/Lippes loop) were analysed for the rate of H2O2 formation. The mean value for a normal proliferative endometrium was 10.56 +/- 1.45 nmoles H2O2 per milligram protein per 2 min, whereas the rate observed for samples of the same phase of the IUCD-fitted group without any bleeding episodes was 14.76 +/- 1.28 and that for members of the same group but who experienced excessive menstrual blood loss (menorrhagia) was 17.26 +/- 2.00, which was significantly higher than that of the control group.
D000328:Adult; D001706:Biopsy; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007435:Intrauterine Devices, Copper
D006861:Hydrogen Peroxide