title: On the nature of the deep cellular disturbances in human-papilloma-virus infection of the squamous cervical epithelium.
abstract: In the squamous epithelium of the cervix, disturbed deep cells, usually regarded as dysplastic, often underlie superficial koilocytes. Recognition of koilocytosis as a cytopathic effect of human papilloma virus (HPV) prompts reconsideration of the state of the deep cells, which could be non-dysplastic or dysplastic. In the dysplastic states HPV could be non-causative or causative. For dysplastic causation by HPV, a cell-differentiation hypothesis reconciles the coexistence in the epithelium of a permissive HPV infection of the superficial layers (koilocytosis) and a non-permissive cellular infection of the deep layers, which may undergo transformation to dysplasia.
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D002584:Cervix Uteri / Q000382:microbiology / Q000473:pathology*; D004848:Epithelium / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D008954:Models, Biological; D027383:Papillomaviridae / Q000254:growth & development; D018139:Simplexvirus / Q000254:growth & development; D014412:Tumor Virus Infections / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000382:microbiology / Q000473:pathology; D014779:Virus Replication