The effect of different histamine H2-receptor antagonists on the gastric acid secretion of the isolated whole stomach of the mouse and on the heart rate of spontaneously beating atrium of the guinea-pig.
The effect of metiamide, cimetidine and 2-[2-[5-(dimethylaminomethyl)furan-2-ylmethylthio]ethylamino]- 5-(6-methylpyrid-3-ylmethyl)-pyrimidin-4-one (SK & F 93 479) was studied on the acid secretion of the isolated stomach of the mouse and on the heart rate of the right atrium of the guinea-pig. The order of potency of histamine H2-antagonists investigated was identical on atrium and stomach, however, the pA2 values obtained on acid secretion were approximately 10 times lower than those found on atrium.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008785:Metiamide / Q000494:pharmacology; D051379:Mice; D011744:Pyrimidinones / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D011744:Pyrimidinones; D008785:Metiamide; C033275:SK&F 93479; D002927:Cimetidine