Chronic administration of antidepressant drugs increases the density of cortical [3H]prazosin binding sites in the rat.
Administration of antidepressants (imipramine, citalopram) or antidepressant neuroleptics (levomepromazine, chlorprothixene) for 14-24 days enhanced by 20-30% the density of [3H]prazosin binding sites in the membranes from the cerebral cortex of the rat, without significant change in their affinity.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism*; D002749:Chlorprothixene / Q000494:pharmacology; D015283:Citalopram; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D008728:Methotrimeprazine / Q000494:pharmacology; D011224:Prazosin / Q000378:metabolism*; D011437:Propylamines / Q000494:pharmacology; D011799:Quinazolines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013134:Spiperone / Q000494:pharmacology
D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D011437:Propylamines; D011799:Quinazolines; D015283:Citalopram; D013134:Spiperone; D008728:Methotrimeprazine; D002749:Chlorprothixene; D007099:Imipramine; D011224:Prazosin