In vitro occurrence of m-octopamine in the cultured cephalic ganglion of Locusta migratoria L. after L-dopa administration.
Cephalic ganglia of the locust Locusta migratoria L. were cultured in the presence of L-DOPA and inhibitors of dopa decarboxylase or dopamine beta hydroxylase. The addition of L-DOPA to the culture medium resulted in a marked increase of m-octopamine, following higher levels of dopamine. L-DOPA produced an increase of m-tyramine. RO 44602 considerably reduced the levels of p and m-octopamines, m-tyramine, dopamine and noradrenaline while fusaric acid reduced only those of p and m-octopamines, m-tyramine and noradrenaline. Though not normally found in the locust nervous system, m-octopamine appears to be closely related to catecholamines and to be produced via their biosynthesizing enzymes through a hypothetical dehydroxylation step.
D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D001679:Biogenic Amines / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D005669:Fusaric Acid / Q000494:pharmacology; D005724:Ganglia / Q000187:drug effects*; D006110:Grasshoppers / Q000378:metabolism*; D006257:Head; D007700:Kinetics; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D009655:Octopamine / Q000378:metabolism*; D009924:Organ Culture Techniques; D014439:Tyramine / Q000378:metabolism
D001679:Biogenic Amines; D002395:Catecholamines; D009655:Octopamine; D007980:Levodopa; D001545:Benserazide; C028435:2-octopamine; D005669:Fusaric Acid; D014439:Tyramine