Increased amine turnover in several hypothalamic noradrenaline nerve terminal systems and changes in prolactin secretion in the male rat by exposure to various concentrations of toluene.
Subacute exposure of rats to varying concentrations of toluene vapours leads to increases of amine levels and turnover in several types of hypothalamic noradrenaline nerve terminal systems. Furthermore, the exposure of toluene in concentrations ranging from 80-3000 ppm and benzene (1500 ppm) produced differential effects on dopamine and noradrenaline turnover within various parts of the hypothalamus. These regions are involved in neuroendocrine regulation and disturbances in the secretion of prolactin were demonstrated after exposure to toluene.
D000818:Animals; D001554:Benzene / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009411:Nerve Endings / Q000187:drug effects* / Q000378:metabolism; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012997:Solvents / Q000494:pharmacology; D014050:Toluene / Q000494:pharmacology*; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
D002395:Catecholamines; D010908:Pituitary Hormones, Anterior; D012997:Solvents; D014050:Toluene; D011388:Prolactin; D014446:Tyrosine 3-Monooxygenase; D001554:Benzene