[Use of plasma calcitonin levels in the detection of Sipple syndrome in siblings (clinicopathological conference)].
In a 22-year old man plasma calcitonin was normal in the basal state but elevated to 2.6 ng/ml after stimulation with calcium and pentagastrin. Two other family members had had bilateral pheochromocytoma accompanied by medullary carcinoma of the thyroid in one case and by adenomas of the parathyroid glands in the other. The literature of Sipple's syndrome, the value of calcitonin assay and the grounds for screening in affected families are reviewed. Surgery (total thyroidectomy) confirmed the clinical suspicion of C-cell hyperplasia and medullary microcarcinoma of the thyroid gland. Hyperplasia of the parathyroid glands was also found.
D000328:Adult; D002116:Calcitonin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000097:blood / Q000175:diagnosis* / Q000235:genetics
D002116:Calcitonin
Confrontation anatomo-clinique. Dépistage par la calcitonine plasmatique dans une fratrie atteinte de syndrome de Sipple.