Sustained release aminophylline in asthma and its interaction with rimiterol.
Twenty chronic asthmatics who completed a double-blind cross-over study comparing sustained release aminophylline tablets with placebo had a significant improvement in airways obstruction. Inhaled rimiterol and the aminophylline tablets were shown to act in an additive manner. There was a significant reduction in asthmatic symptoms on active tablets. A further nine patients had to be withdrawn from the study because of adverse side effects.
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002396:Catechols / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D010919:Placebos
D000336:Aerosols; D002396:Catechols; D003692:Delayed-Action Preparations; D010880:Piperidines; D010919:Placebos; C084590:rimiterol; D000628:Aminophylline