Beta-adrenoceptor antagonists may attenuate hyponeophagia in the rat through a serotonergic mechanism.
The unconditioned inhibition of feeding in a novel setting (hyponeophagia) was reduced by propranolol and another potentially centrally acting beta-adrenoceptor antagonist, pindolol but not by a peripherally acting one, atenolol. A similar attenuation of hyponeophagia was seen following the 5-HT antagonist methysergide but no consistent effects were observed following some dopamine antagonist drugs. 5-Methoxy N,N-dimethyltryptamine (5-MeODMT), a compound with central 5-HT agonist properties, consistently potentiated hyponeophagia, an effect which was reversed by the centrally acting beta-adrenoceptor antagonists and by methysergide. The results are interpreted as evidence for a 5-HT mediation of hyponeophagia and for a probable central 5-HT antagonist role for propranolol and pindolol.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D005260:Female; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D008732:Methoxydimethyltryptamines; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D011433:Propranolol; D010869:Pindolol; D002746:Chlorpromazine; D008784:Methysergide