Beta-adrenoceptor blockade and anaesthesia for thyroidectomy.
The administration of beta-adrenoceptor blocking drugs in the pre-operative preparation and operative management of thyrotoxic patients undergoing subtotal thyroidectomy is reviewed. Particular reference is made to some of the recent advances and it is emphasised that there has been a considerable reduction in the incidence of problems following judicious use of these drugs. The choice of anaesthetic technique employed for thyroidectomy is less important than the degree of control of thyrotoxicosis by the beta-adrenoceptor blocking drug. Propranolol has proved safe and effective for the majority of patients. The longer acting agent nadolol is easier to administer, particularly in the peri-operative period. Patients are rendered less thyrotoxic and safety thereby enhanced by adding potassium iodide for 10 days preoperatively. The combination of nadolol and potassium iodide offers real advantages in the preparation of the thyrotoxic patient for surgery.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000768:Anesthesia, General; D001786:Blood Glucose / Q000032:analysis; D004359:Drug Therapy, Combination; D006728:Hormones / Q000097:blood; D006801:Humans; D009248:Nadolol; D011193:Potassium Iodide / Q000627:therapeutic use; D011292:Premedication; D011412:Propanolamines / Q000627:therapeutic use; D011433:Propranolol / Q000097:blood / Q000627:therapeutic use; D013958:Thyroid Crisis / Q000209:etiology; D013965:Thyroidectomy; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D006728:Hormones; D011412:Propanolamines; D011193:Potassium Iodide; D009248:Nadolol; D011433:Propranolol