Quantitative analysis of melperone in human plasma by gas chromatography--mass spectrometry--selected ion monitoring.
A sensitive, specific and reliable assay utilizing a combined gas chromatography--mass spectrometry--selected ion monitoring technique is described for the quantitative determination of melperone, a neuroleptic agent, in human plasma. Using a 2-ml plasma sample, the method is sensitive and has acceptable precision in the range of 1 to 100 ng/ml. The method is applied in a limited bioavailability study and found to be adequate. A plasma metabolite was isolated and identified in the clinical samples.
D014150:Antipsychotic Agents / Q000097:blood; D002090:Butyrophenones / Q000097:blood* / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013997:Time Factors
D014150:Antipsychotic Agents; D002090:Butyrophenones; C008522:metylperon