The relationship between molecular connectivity and partition coefficients.
Kier & Hall (1976) demonstrated that a relationship existed between molecular connectivity and Log P (the Log of the octanol/water partition coefficient) for several classes of compounds and also for the combined classes. This work utilized a number of Log P values calculated using Pi values. We have reinvestigated this relationship using experimentally determined Log P values. The results confirm Kier & Hall's findings although different connectivity indices are brought into the equations.
D000438:Alcohols; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D012995:Solubility; D014867:Water
D000438:Alcohols; D014867:Water