Successful bone-marrow transplantation for reticular dysgenesis.
A male infant with reticular dysgenesis received a bone-marrow transplant from his HLA-identical brother. Severe graft-versus-host disease developed but he responded to high-dose methylprednisolone. 3 years after grafting, the child is thriving with full haematological reconstitution and normal cell-mediated and humoral immunity. This is the first report of the survival beyond 17 weeks of a child with reticular dysgenesis.
D000208:Acute Disease; D000380:Agranulocytosis / Q000097:blood / Q000151:congenital / Q000628:therapy; D016026:Bone Marrow Transplantation; D001942:Breast Feeding; D005500:Follow-Up Studies; D006087:Graft vs Host Reaction; D006801:Humans; D007116:Immunization, Passive; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000151:congenital / Q000628:therapy*; D007223:Infant; D008297:Male; D008895:Milk, Human / Q000276:immunology