Eimeria stiedai in rabbits: the demonstration of responses to chemotherapy.
The activity of sulphaquinoxaline, robenidine, methyl benzoquate, clopidol and a mixture of methyl benzoquate and clopidol (Lerbek; Dow), was studied in rabbits infected with hepatic coccidiosis due to Eimeria stiedai. Growth inhibition, oocyst production and the activity in the serum of glutamate dehydrogenase and gamma glutamyltransferase were studied as indicators of parasite development. Only sulphaquinoxaline and Lerbek gave satisfactory control of this parasite. The latter formulation was more effective than either of its constituents used alone.
D000818:Animals; D003007:Clopidol / Q000627:therapeutic use; D003048:Coccidiosis / Q000188:drug therapy / Q000201:enzymology / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D004338:Drug Combinations; D005969:Glutamate Dehydrogenase / Q000097:blood; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000201:enzymology / Q000662:veterinary*; D011804:Quinolines / Q000627:therapeutic use; D015363:Quinolones; D011817:Rabbits; D012370:Robenidine / Q000627:therapeutic use; D013428:Sulfaquinoxaline / Q000627:therapeutic use; D005723:gamma-Glutamyltransferase / Q000097:blood
D003049:Coccidiostats; D004338:Drug Combinations; D011804:Quinolines; D015363:Quinolones; D012370:Robenidine; D003007:Clopidol; C057040:nequinate; D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D013428:Sulfaquinoxaline