title: Biochemistry, pathophysiology and pharmacology of slow-reacting substances/leukotrienes.
abstract: The chemistry, biosynthesis and general pharmacology of leukotrienes C4 and D4 are reviewed, with emphasis on the cardiovascular and smooth muscle effects of these agents. Pathways controlling the formation of the leukotrienes are considered together with their possible pathophysiological roles.
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D012898:Autacoids / Q000378:metabolism / Q000502:physiology*; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D009119:Muscle Contraction / Q000187:drug effects; D013189:SRS-A / Q000302:isolation & purification / Q000378:metabolism; D013045:Species Specificity
chemical_list: D001095:Arachidonic Acids; D012898:Autacoids; D013189:SRS-A; D016718:Arachidonic Acid