Oxidation of beta-DL-thiaproline, a possible natural substrate of D-aminoacid oxidase.
Beta-DL-Thiaproline (thiazolidine 2-carboxylic acid) is a good substrate for hog kidney D-aminoacid oxidase. Unlike other known substrates, beta-thiaproline is better oxidized at neutral than at alkaline pH. At neutral pH beta-thiaproline is a better substrate than D-proline. Beta-DL-thiaproline is fully oxidized to delta 2 thiazoline 2-carboxylic acid, which in acidic medium is hydrolyzed to N-oxalylcysteamine. These results may support the suggestion that beta-thiaproline, arising in vivo from cysteamine and glyoxylate, can be a possible physiological substrate for D-aminoacid oxidase.
D000603:Amino Acids, Sulfur; D000818:Animals; D003605:D-Amino-Acid Oxidase / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D011392:Proline / Q000031:analogs & derivatives*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013552:Swine; D053778:Thiazolidines
D000603:Amino Acids, Sulfur; D053778:Thiazolidines; C021760:thiazolidine-2-carboxylic acid; D011392:Proline; D003605:D-Amino-Acid Oxidase