[DNA changes in a nonischemic area of the rat myocardium in experimental myocardial infarct and its prevention].
DNA damage and repair in the nonischemic area of the heart were analyzed after experimental myocardial infarction to evaluate the effect on these processes of the beta-blocker inderal and lipid peroxidation inhibitor ionol. It was found that in the nonischemic area of the heart, DNA damage was manifested by the decreased polymerism averted to a significant degree by inderal and ionol which interfered with postinfarction activation of lipid peroxidation. Accordingly, inderal and, to a greater degree, ionol reduced postinfarction activation of DNA repair synthesis in the nonischemic area of the heart.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D003327:Coronary Disease / Q000378:metabolism* / Q000517:prevention & control; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism*; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D000319:Adrenergic beta-Antagonists; D002084:Butylated Hydroxytoluene; D004247:DNA; D011433:Propranolol
Povrezhdenie DNK v neishemizirovannoĭ zone serdechnoĭ myshtsy krys pri éksperimental'nom infarkte miokarda i ego preduprezhdenie.