The influence of topical beta-blockers on the breakup time.
In a double-blind masked study with 100 young and healthy subjects we compared the influence of the beta-blocking agents timolol and metipranol on breakup time and their tolerance. While metipranolol provoked a slight burning sensation, timolol was well tolerated. Both beta-blockers, however, led to an equally enormous reduction in BUT in short-term observations.
D000328:Adult; D004311:Double-Blind Method; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D014290:Metipranolol / Q000009:adverse effects*; D009883:Ophthalmic Solutions; D011412:Propanolamines / Q000009:adverse effects*; D013666:Tears / Q000187:drug effects*; D013999:Timolol / Q000009:adverse effects*
D009883:Ophthalmic Solutions; D011412:Propanolamines; D013999:Timolol; D014290:Metipranolol