Kappa-opioid diuretic effects of tifluadom, a benzodiazepine opioid agonist.
Tifluadom produced a dose-related (0.08-5 mg kg-1) diuresis in normally hydrated rats. This diuretic effect was antagonized by kappa-antagonist doses of naloxone and blocked by morphine administration. This is further in-vivo evidence that tifluadom is a fairly specific kappa-opioid agonist.
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects*; D017473:Receptors, Opioid, kappa; D013997:Time Factors
D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D001569:Benzodiazepines; D009270:Naloxone; D009020:Morphine; C035470:tifluadom