Effect of food, fluid and dosage form on the absorption of 52-522, a potential antianxiety agent, in the dog.
The absorption of 52-522 in the dog was studied by measuring blood concentrations of radioactivity after single oral doses of [14C] 52-522 in a capsule with and without water, also as a food-drug mixture, and a solution in polyethylene glycol 400. Absorption was rapid, and its rate moderate with no significant differences in peak times among treatments. The extent of absorption was lowest after the capsulated [14C] 52-522. The solution dose gave elevated blood concentrations, that were statistically significantly different when compared with the capsules. Hence, it appears that the absorption of [14C] 52-522 is governed by the degree of dispersion of drug in the dosage form.
D000042:Absorption; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000378:metabolism*; D004285:Dogs; D004326:Drinking; D004435:Eating; D008297:Male; D011728:Pyridones / Q000378:metabolism*
D014151:Anti-Anxiety Agents; D011728:Pyridones; C040429:SAN 52522