title: A possible role for somatostatin in depression of insulin and glucagon levels during hemorrhage.
abstract: The hypothesis that depression of insulin and glucagon levels during rapid, acute hemorrhage is controlled by somatostatin was supported by hormonal changes measured in the cat. By 5 min of hemorrhage to 50 mmHg (1 mmHg = 133.322 Pa) arterial blood pressure, insulin and glucagon were severely depressed and somatostatin levels rose to 232% of basal levels. Insulin and glucagon suppression was maintained for the 30-min period of hemorrhage. Following return of the blood, somatostatin levels remained high and insulin and glucagon suppression was maintained. The data support, but do not prove, the hypothesis.
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology; D002415:Cats; D005260:Female; D005934:Glucagon / Q000097:blood*; D006470:Hemorrhage / Q000097:blood* / Q000503:physiopathology; D007328:Insulin / Q000097:blood*; D008297:Male; D013004:Somatostatin / Q000097:blood / Q000502:physiology*
chemical_list: D007328:Insulin; D013004:Somatostatin; D005934:Glucagon