Rifampicin induction of myopathy: lack of a direct effect on rat neuromuscular system.
The effect of acute administration of rifampicin on neuromuscular transmission was tested, in-vivo, in the rat. Rifampicin did not alter the strength of contraction of the muscle indirectly stimulated at various frequencies. Additional isoniazid pretreatment did not alter the absence of effect of rifampicin on neuromuscular action.
D000818:Animals; D008297:Male; D009135:Muscular Diseases / Q000139:chemically induced*; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012293:Rifampin / Q000633:toxicity*
D012293:Rifampin