title: Benzodiazepines: selective use to avoid addiction.
abstract: When judiciously used, benzodiazepines are therapeutically effective and remarkably safe. Long-term use may result in addiction and physical dependence in some patients. The physician's awareness of this risk helps in the prevention of dependence. Four variables play a part in the development of dependence, ie, dose, duration of treatment, the history, and the patient's personality. A dosage higher than the usual therapeutic dose not only is not needed in most patients but produces more side effects. Short term therapy carries a low risk of dependence and is preferred. It is advisable not to use benzodiazepines in patients with a history of alcohol or drug abuse, as dependent personalities pose a higher risk than other personality types.
mesh_terms: D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy; D001569:Benzodiazepines; D006801:Humans; D019966:Substance-Related Disorders / Q000517:prevention & control
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines