A possible correlate of the postsynaptic condition for long-lasting potentiation in the guinea pig hippocampus in vitro.
Picrotoxin and 2-amino-5-phosphonovalerate (APV) have previously been reported to influence the production of long-lasting potentiation in the hippocampus (facilitation and depression, respectively). We have examined how these drugs modify the postsynaptic responses to tetanic afferent activation used to elicit long-lasting potentiation. The experiments were performed in the CA1 area of transverse hippocampal slices maintained in vitro. A slow extracellular dendritic negativity-interpreted as a sign of a dendritic depolarizing process-was enhanced by picrotoxin and depressed by APV. This dendritic potential may represent a postsynaptic event involved in the production of long-lasting potentiation.
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D004594:Electrophysiology; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D010852:Picrotoxin / Q000494:pharmacology; D013569:Synapses / Q000502:physiology*; D013997:Time Factors; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D015763:2-Amino-5-phosphonovalerate; D010852:Picrotoxin; D014633:Valine