A controlled trial of brotizolam versus flunitrazepam as a hypnotic.
Brotizolam, a new thieno-triazolodiazepine, was tested against flunitrazepam and placebo on patients the night before surgery. Flunitrazepam had a shorter onset of action while brotizolam caused longer and deeper sleep with no gastro-intestinal side-effects. It was preferred to flunitrazepam by the patients.
D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001381:Azepines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005445:Flunitrazepam / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D011300:Preoperative Care; D011897:Random Allocation; D012890:Sleep / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D001381:Azepines; D006993:Hypnotics and Sedatives; C020960:brotizolam; D005445:Flunitrazepam