Dynorphin-(1-13)-like immunoreactivity in central nervous system and pituitary gland of spontaneously hypertensive rats.
We determined by radioimmunoassay concentration of dynorphin-(1-13)-like immunoreactivity in the central nervous system and pituitary gland of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto rats (WKYs). Compared to WKYs, SHRs had significantly lower levels of dynorphin-(1-13)-like immunoreactivity in the hypothalamus and pituitary gland. However, such immunoreactivity in the cerebral cortex, caudate nucleus, diencephalon, brainstem and spinal cord of SHRs and WKYs were similar.
D000818:Animals; D000941:Antigens; D002490:Central Nervous System / Q000032:analysis / Q000276:immunology*; D004399:Dynorphins; D004723:Endorphins / Q000032:analysis / Q000276:immunology*; D006973:Hypertension / Q000276:immunology* / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments / Q000032:analysis / Q000276:immunology*; D010902:Pituitary Gland / Q000032:analysis / Q000276:immunology*; D011863:Radioimmunoassay; D051381:Rats
D000941:Antigens; D004723:Endorphins; D010446:Peptide Fragments; D004399:Dynorphins