The use of liposomes in the topical application of steroids.
The effect of topical application of the androgen 5 alpha-dihydrotestosterone (DHT), both encapsulated in liposomes and solved in acetone, has been evaluated using the female hamster flank organ as a model system. Systemic absorption of DHT was significant from the acetone solution, but negligible from the liposome system. The topical biological effect is, however, proportionally diminished when the liposome system is used. Under the experimental conditions used, the lited using the female hamster flank organ as a model system. Systemic absorption of DHT was significant from the acetone solution, but negligible from the liposome system. The topical biological effect is, however, proportionally diminished when the liposome system is used. Under the experimental conditions used, the liposome system had no advantages over application in acetone in this model.
D000287:Administration, Topical; D000818:Animals; D006224:Cricetinae; D013196:Dihydrotestosterone / Q000008:administration & dosage; D005260:Female; D008081:Liposomes / Q000008:administration & dosage*; D012627:Sebaceous Glands / Q000502:physiology; D012867:Skin / Q000033:anatomy & histology; D013256:Steroids / Q000008:administration & dosage*
D008081:Liposomes; D013256:Steroids; D013196:Dihydrotestosterone