title: [Peculiarities of neurohumoral regulation of stomach function in the human in later and advanced age].
abstract: The process of aging of the human organism is accompanied by certain changes in the regulation of the secretory activity of the stomach. This applies to the neural mechanisms of regulation just as much as to the humoral ones. Quite often such changes are opposed. The significance of cholinergic mechanisms is reduced whereas that of adrenergic mechanisms is growing; the nerve influences get increasingly weaker and the humoral influences comparatively greater; the effect of the central structures decreases and the influence of the intramural nervous apparatus increases. The changed responsiveness of secretory cells from the stomach with respect to regulatory factors calls for the development of mechanisms of adaptation to the new level of the correlation between the neural and humoral factors, which represents a senile evolution of the system of neurohumoral regulation. In our opinion the observed changes in the neurohumoral regulation of the secretory activity of the stomach constitute one of the chief causes of the peculiarities of the functional state of the secretory apparatus in man which develop in advanced age.
mesh_terms: D000368:Aged; D001921:Brain / Q000503:physiopathology; D004837:Epinephrine / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000503:physiopathology; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000502:physiology; D011950:Receptors, Cholinergic / Q000502:physiology; D013270:Stomach / Q000294:innervation*; D014630:Vagus Nerve / Q000503:physiopathology
chemical_list: D005755:Gastrins; D018377:Neurotransmitter Agents; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D004837:Epinephrine
vernacular_title: Besonderheiten der neurohumoralen Regulation der Magenfunktion bei Menschen höheren und hohen Alters.