[Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium].
A 26-year-old female patient was admitted 30 minutes after suicidal poisoning with 750 mg amitriptyline (Saroten), 4800 mg dibenzepine (Noveril retard) and 2100 mg thioridazine (Melleril). Life threatening disturbances of cardiac rhythm occurred in addition to coma, pulmonary insufficiency requiring assisted ventilation, and hypotension. Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl.
D000639:Amitriptyline / Q000506:poisoning; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000188:drug therapy; D003984:Dibenzazepines / Q000506:poisoning; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D010830:Physostigmine / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000627:therapeutic use*; D013881:Thioridazine / Q000506:poisoning
D000929:Antidepressive Agents, Tricyclic; D003984:Dibenzazepines; D000639:Amitriptyline; D012965:Sodium Chloride; D010830:Physostigmine; D013881:Thioridazine
Arrhythmien bei Vergiftung durch trizyklische Antidepressiva. Erfolgreiche Behandlung mit Physostigmin und Natrium.