title: Studies on the metabolism of tulobuterol . HCl. Identification of basic urinary metabolites in the dog, rat, rabbit, and guinea pig.
abstract: The metabolism of tulobuterol, a new bronchodilating agent, has been studied in the dog, rat, rabbit, and guinea pig. Major basic metabolites of tulobuterol excreted in the urine were identified by comparison of the retention times of a gas chromatogram and/or a mass chromatogram, and of mass spectra with those of the authentic compounds. 4,5-Dihydroxytulobuterol and/or 4-hydroxy-3-methoxytulobuterol were identified in the urine of these species. There were species differences in the extent and direction of ring-hydroxylation and subsequent O-methylation.
mesh_terms: D000818:Animals; D001711:Biotransformation; D004285:Dogs; D008401:Gas Chromatography-Mass Spectrometry; D006168:Guinea Pigs; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013726:Terbutaline / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine
chemical_list: C010809:tulobuterol; D013726:Terbutaline