On the contractile activity and reactivity of sheep myometrial strips in juvenile, anoestral and gravid periods.
Spontaneous contractions of uterine muscle strips from juvenile, anoestral and pregnant sheep were recorded in vitro isometrically. There is a spontaneous contractile activity irrespective of hormonal status of the animals. Acetylcholine increases the tone and frequency of the phasic contractions of uterine corpus and horn preparations from the three groups of animals. The adrenaline excitatory effect on the myometrial contractions was mediated by alpha-adrenoreceptors. The pregnant uterine strips showed strengthening of the inhibitory effect mediated by the beta-adrenoreceptors.
D000109:Acetylcholine / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000780:Anestrus; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D004971:Estrus; D005260:Female; D066298:In Vitro Techniques; D011247:Pregnancy; D011270:Pregnancy, Animal; D012741:Sexual Maturation; D012756:Sheep; D014590:Uterine Contraction / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000109:Acetylcholine; D004837:Epinephrine