Effect of alpha-methyl-p-tyrosine on neuroleptic-induced catalepsy in rat.
Pretreatment with alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, was found to increase the intensity of catalepsy induced by haloperidol, chlorpromazine and molindone. The drug probably decreases the synthesis of dopamine and makes less dopamine available for release and to compete with the neuroleptic for the postsynaptic striatal dopamine receptor sites with resultant potentiation of the neuroleptic-induced catalepsy.
D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity*; D002375:Catalepsy / Q000139:chemically induced*; D002746:Chlorpromazine / Q000633:toxicity; D004298:Dopamine / Q000096:biosynthesis; D004357:Drug Synergism; D006220:Haloperidol / Q000633:toxicity; D006801:Humans; D008297:Male; D008781:Methyltyrosines / Q000633:toxicity*; D008972:Molindone / Q000633:toxicity; D051381:Rats; D019805:alpha-Methyltyrosine
D014150:Antipsychotic Agents; D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D006220:Haloperidol; D008972:Molindone; D002746:Chlorpromazine; D004298:Dopamine