Association between HLA-B antigens and acute graft-versus-host disease.
130 patients with severe aplastic anaemia, conditioned with high-dose cyclophosphamide, showed sustained engraftment of marrow from HLA-identical siblings. Most patients (55%) had no acute graft-versus-host disease (GVHD), 11% had transient grade I, and 34% had moderate to severe (grades II-IV) acute GVHD. The relation between the donors' (and the patients') HLA antigens and the incidence of grades I-IV acute GVHD was explored. There was no association with HLA-A antigens, but a significant correlation with HLA-B antigens. Patients with HLA-B18 had an estimated acute GVHD incidence nearly three times that of other patients, whereas the incidence in the presence of HLA-B8 or HLA-Bw35 was estimated to be about half that in the absence of these alleles.
D000208:Acute Disease; D000483:Alleles; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D006801:Humans; D011379:Prognosis
D006680:HLA Antigens; D015235:HLA-B Antigens