Thy-1 determinants are present on many murine hematopoietic cells other than T cells.
The development of a highly amplified immunofluorescence assay and the availability of monoclonal anti-Thy-1 antibodies have provided the methodology to reexamine the presence of Thy-1 antigen on murine lymphohematopoietic cells. The representation of this antigen is not, as previously believed, restricted to the T cell compartment of these cells. It is present on a significant number of mouse bone marrow cells (25-30%), including, as in the rat, multipotential stem cells, prothymocytes and some B cell precursors. Eosinophils and some immature myeloid cells are also antigen-positive.
D000818:Animals; D000954:Antigens, Surface; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002469:Cell Separation; D003114:Colony-Forming Units Assay; D005434:Flow Cytometry; D006098:Granulocytes / Q000166:cytology / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007106:Immune Sera / Q000494:pharmacology; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009000:Monocytes / Q000166:cytology / Q000276:immunology; D011817:Rabbits; D051381:Rats; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology / Q000276:immunology*; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D007106:Immune Sera; D018800:Thy-1 Antigens