[Mechanism of action of the new antibiotic kirromycin].
The discovery and the elucidation of the mechanism of action of a new family of antibiotics is described. These antibiotics, here represented by kirromycin, all inhibit bacterial protein synthesis by acting on the protein elongation factor Tu, blocking its release from the ribosome during the elongation cycle and thereby inhibiting peptide bond formation. A number of these compounds have been successfully used as feed additives.
D000821:Animal Feed; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D020963:GTP Phosphohydrolase-Linked Elongation Factors / Q000378:metabolism; D009154:Mutation; D010445:Peptide Elongation Factors / Q000037:antagonists & inhibitors; D011728:Pyridones / Q000494:pharmacology; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D010445:Peptide Elongation Factors; D011728:Pyridones; D012346:RNA, Transfer, Amino Acyl; D020963:GTP Phosphohydrolase-Linked Elongation Factors; C008536:mocimycin
Mécanisme d'action du nouvel antibiotique kirromycine.