Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat.
In this study of the rat hippocampal CA1 stratum radiatum 4 days after 20 min transient cerebral ischaemia, we demonstrated ultrastructural dendritic degeneration and loss, whereas most axons appeared undamaged. Autoradiographs 4 days after ischaemia showed unchanged Na+-dependent glutamate high affinity uptake. The role of glutamate and Ca2+ for this selective postsynaptic vulnerability is discussed.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism; D003712:Dendrites / Q000648:ultrastructure; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D018698:Glutamic Acid; D002118:Calcium