title: Arteriolar vasoconstriction in rat cremaster muscle induced by local heat stress.
abstract: The effect of moderate local heat stress on arteriolar tone in the cremaster muscle of anesthetized rats was investigated by direct microscopic observation. Muscle temperature was raised from the in vivo temperature of 34.5 to 38 degrees C, over a 5-min period, by elevating bath temperature. Muscle temperature, arteriolar lumen diameter, and arteriolar red blood cell velocity were continuously recorded. A number of the smallest arterioles studied (approximately 30 micrometers lumen diam) underwent a rapid and significant vasoconstriction near 36 degrees C. Denervation  of the muscle eliminated the constrictor response. Addition of an alpha-blocking agent (dibenzyline to the denervated muscle unmasked the constriction, but the percent of arterioles demonstrating thermal reactivity remained decreased. We conclude that in some skeletal muscle beds a local thermoregulatory mechanism may exist whereby blood is shunted away from the tissue during heat stress at rest.
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001160:Arterioles / Q000502:physiology; D004909:Erythrocyte Indices; D006358:Hot Temperature; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000098:blood supply*; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000317:Adrenergic alpha-Antagonists; D010643:Phenoxybenzamine