Effect of dibutylnitrosamine and saccharin on glutamyl transpeptidase-positive foci and liver cancer.
Consistent with the proposed precursor relationship of GGTase-positive foci to hepatocarcinogenesis, the induction of foci by DBN was associated with the induction of hyperplastic nodules and hepatocellular carcinoma and the concurrent administration of sodium saccharin in the diet with DBN in the drinking water increased the tumorigenic response in the liver to DBN.
D000818:Animals; D003043:Cocarcinogenesis; D008113:Liver Neoplasms / Q000139:chemically induced*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D009602:Nitrosamines; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000201:enzymology; D051381:Rats; D012439:Saccharin / Q000633:toxicity; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D009602:Nitrosamines; C012279:dibutylnitrosamine; D005723:gamma-Glutamyltransferase; D012439:Saccharin