Altered copper metabolism in heterozygous tortoiseshell (Moto/+) female mice, Mus musculus.
1. The copper concentration of various tissues and excrement of normal (+/+) and heterozygous tortoiseshell (Moto/+) female mice were examined by atomic absorption spectrophotometry (AAS). 2. The kidney, duodenum and spleen of Moto/+ female mice exhibited increased copper levels. 3. A reduced copper content was detected in the plasma and erythrocytes of Moto/+ females. 4. The feces and urine of Moto/+ females exhibited elevated copper concentrations. 5. The other tissues examined (e.g. liver, lung) showed no significant copper level alterations.
D000818:Animals; D003300:Copper / Q000378:metabolism*; D005260:Female; D006579:Heterozygote; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D013045:Species Specificity; D014018:Tissue Distribution
D003300:Copper