Influence of chlorpromazine, reserpine and lithium carbonate upon the induction of the tyrosine aminotransferase (TAT) in the rat liver.
The influence of chlorpromazine, reserpine, and lithium carbonate upon the induction of the tyrosine aminotransferase (TAT) in the rat liver of normal and adrenalectomized animals as well as in the presence of nicotinamide, DL-tryptophan, and L-methionine was studied. In normal animals, the TAT is significantly induced only by chlorpromazine, not, however, by reserpine and lithium carbonate. Especially the effect of chlorpromazine upon the induction is enhanced by methionine or by a combination of tryptophan and methionine. An additional administration of prednisolone slightly inhibits the induction. In adrenalectomized animals, the psychotropic substances used are very toxic. By a combination with tryptophan, a minimal induction can be observed. Prednisolone causes a complete restoration of the induction. In combination with the hormone, lithium carbonate produces the highest values. This effect can be intensified by a simultaneous administration of tryptophan.
D000315:Adrenalectomy; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008094:Lithium / Q000494:pharmacology*; D016651:Lithium Carbonate; D008099:Liver / Q000201:enzymology*; D008715:Methionine / Q000494:pharmacology; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology*; D014364:Tryptophan / Q000494:pharmacology; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D009536:Niacinamide; D016651:Lithium Carbonate; D012110:Reserpine; D014364:Tryptophan; D008094:Lithium; D011239:Prednisolone; D008715:Methionine; D014444:Tyrosine Transaminase; D002746:Chlorpromazine; C024058:N(1)-methylnicotinamide