title: Post-excitatory depression of neuronal firing by acidic amino acids and acetylcholine in the cat spinal cord.
abstract: In the spinal cord of cats anaesthetized with pentobarbitone, the excitation of interneurones and Renshaw cells by acidic amino acids or acetylcholine (Renshaw cells) is followed by a period of depressed excitability. This depression appears to be the consequence of prolonged repetitive firing rather than of the enzymic or chemical conversion of the excitants to neuronal depressants.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D002415:Cats; D005071:Evoked Potentials / Q000187:drug effects; D005727:Ganglia, Spinal / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007395:Interneurons / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D000109:Acetylcholine