Triazolam concentration-effect relationships in healthy subjects.
Triazolam was used to study the plasma concentration-effect relationship of a benzodiazepine because it has a very short plasma t1/2. A standard hypnotic dose of 0.25 mg was given by mouth to six healthy subjects, and blood samples were drawn when the subjects had to perform a battery of psychologic tests. Only the digit-symbol substitution test, the card-sorting test according to numbers, and the visual analog scale (energetic-lethargic) gave significant results. Analysis of the concentration-effect relationship in individuals indicated a wide scatter of the data. Mean values revealed a trend for a learning effect in the card-sorting test. The results are consistent with the hypothesis that triazolam is well suited for a study of concentration-effect relationships, but better psychologic tests would be desirable.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008606:Mental Processes / Q000187:drug effects*; D011581:Psychological Tests; D011597:Psychomotor Performance / Q000187:drug effects; D014145:Trail Making Test; D014229:Triazolam / Q000097:blood* / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D014229:Triazolam