title: Comparison of inhibitory effects of substituted benzamides and classical neuroleptics on operant behavior in rats and squirrel monkeys.
abstract: The operant behavioral effects of the substituted benzamides metoclopramide, sultopride and sulpiride were compared with those of chlorpromazine and haloperidol using lateral hypothalamic self-stimulation of the brain in rats and Sidman avoidance responding in rats and squirrel monkeys. All the drugs inhibited both phenomena dose-dependently in rats. The order of potency was: haloperidol greater than chlorpromazine greater than metoclopramide greater than sultopride greater than sulpiride. Sulpiride only produced moderate inhibition even at 128 mg/kg s.c. All drugs also suppressed Sidman avoidance in squirrel monkeys, which were far more sensitive than rats to the inhibitory effects of all three benzamides. In monkeys, sulpiride 8 mg/kg i.m. apparently suppressed Sidman avoidance with a delayed onset and a prolonged duration, which contrasted with the rapid onset and short duration of metoclopramide action. Thus, long-term observation of the behavioral effects of benzamides in squirrel monkeys may provide more precise information on the clinical antipsychotic efficacy of substituted benzamides.
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D012453:Saimiri; D012653:Self Stimulation / Q000187:drug effects*; D013045:Species Specificity
chemical_list: D014150:Antipsychotic Agents; D001549:Benzamides