title: The effects of diltiazem on Periplaneta americana.
abstract: The effects of the calcium antagonist diltiazem on nerve and muscle in the cockroach Periplaneta americana were examined. Diltiazem was observed to inhibit myogenic and glutamate-induced contractions of the visceral muscle while having either a potentiating, an inhibiting or a biphasic effect against proctolin-induced contractions. Against the isolated nervous system, diltiazem induced an increase in spontaneous discharge activity, followed by nerve block. Injection of diltiazem into cockroaches produced behavioral and toxic effects.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D003058:Cockroaches / Q000187:drug effects*; D004110:Diltiazem / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D007422:Intestines / Q000294:innervation; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D010526:Periplaneta / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D001552:Benzazepines; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D004110:Diltiazem