[Evolution of the adaptive functions of hypophyseal hormones detected by using hypothalamic melanostatin].
The content of two pituitary tropins (MSH and ACTH) has been determined in rats which were injected by the synthetic melanostatin to suppress MSH of the intermediate part of pituitary by radioimmune analysis. Besides, the function of the adrenal cortex according the content of corticosterone in various tissues was estimated. It has been revealed that the pituitary-adrenal complex activation is caused by the hypothalamic melanostatin suppression of the MSH secretion. All these testify the ACTH and MSH definite role in organisms adaptive reactions at different evolution steps.
D000222:Adaptation, Physiological / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000818:Animals; D005075:Biological Evolution; D003345:Corticosterone / Q000032:analysis; D007028:Hypothalamic Hormones / Q000494:pharmacology*; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D010907:Pituitary Hormones / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000187:drug effects; D051381:Rats
D007028:Hypothalamic Hormones; D010907:Pituitary Hormones; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D009075:MSH Release-Inhibiting Hormone; D003345:Corticosterone
Evoliutsiia adaptivnykh funktsiĭ nekotorykh gipofizarnykh gormonov, vyiavlennaia s pomoshch'iu gipotalamicheskogo melanostatina.