[Sidnocarb correction of the adverse effects of benzodiazepine tranquilizers].
The correcting action of sydnocarb on the side effects of phenazepam was studied in experimental and clinical conditions. The effect of sydnocarb on the myorelaxant, hypnotic, and tranquilizing effects of phenazepam was determined on 144 mice and 87 rats. Comparative clinical trials of phenazepam with regard to the same effects were carried out on 102 patients with anxious-depressive states. The patients received phenazepam both in combination with sydnocarb and alone. The experiments and the clinical trials have shown that sydnocarb reduces the myorelaxant and hypnotic effects of phenazepam without influencing its tranquilizing action. The phenazepam: sydnocarb ratio optimal for correcting the side effects of the tranquilizer was found to range with 1: 1.25 to 1:2.5.
D000328:Adult; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D001007:Anxiety / Q000188:drug therapy*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D003244:Consciousness Disorders / Q000517:prevention & control; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000517:prevention & control; D010069:Oxadiazoles / Q000008:administration & dosage*; D051381:Rats; D012894:Sleep Stages; D013558:Sydnones / Q000008:administration & dosage*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D010069:Oxadiazoles; D013558:Sydnones; D001569:Benzodiazepines; C017928:phenazepam; C009257:sidnocarb
Korrektsiia sidnokarbom pobochnogo deĭstviia trankvilizatorov benzodiazepinovogo riada.