[Modification of cardiac circulation and respiratory parameters by alfentanil].
In 93 patients (ASA I) undergoing orthopaedic operations respiratory and haemodynamic effects of alfentanil (steady state: spontaneous breathing halothane, N2O/O2) were measured. After injection of alfentanil apnoea was found be readily antagonized by Naloxone. A significant decrease of arterial pressure and heart rate occurred simultaneously independent of dose level. The decrease of arterial pressure could be prevented by pre-injection of atropine. Therefore an increased vagal tone must be responsible for depression of haemodynamic parameters.
D000328:Adult; D015760:Alfentanil; D000701:Analgesics, Opioid / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D000701:Analgesics, Opioid; D015760:Alfentanil; D001285:Atropine; D005283:Fentanyl
Beeinflussung der Herz-Kreislauf- und Ventilationsparameter durch Alfentanil.