Phloretin inhibition of glucose transport by the tapeworm Hymenolepis diminuta: a kinetic analysis.
Phloretin non-competitively inhibits glucose and methionine absorption by Hymenolepis diminuta (Ki = 0.24 and 1.48 mM, respectively). Inhibition of glucose transport by phloretin is reversible. Phloretin and phlorizin binding sites on the surface of H. diminuta are distinct. Phloretin does not inhibit Na+ transport independent of glucose transport in H. diminuta. The data suggest that phloretin inhibits absorptive functions across the surface of H. diminuta via non-specific binding sites associated with the lipid portion of the worm outer membrane.
D000818:Animals; D001667:Binding, Competitive; D001693:Biological Transport, Active / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006926:Hymenolepis / Q000378:metabolism*; D007700:Kinetics; D010693:Phloretin / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D005947:Glucose; D010693:Phloretin