The susceptibility of BALB/C and other inbred mouse strains to Brugia pahangi.
The susceptibility of several strains of inbred mice to infection with the filarial worm Brugia pahangi has been examined. BALB/C, C57BL/10, C3H/He, 101, CBA/Ca mice, congenitally asplenic (DH/+) mice and their normal litter-mates (+/+) were each challenged by the intraperitoneal inoculation of 50 infective larvae. During the first four weeks of infection high (19-42%) larval recoveries were obtained from the CBA/Ca, BALB/C and Dh/+ mice but fewer than 10% of inoculated larvae were recovered from C3H/He, 101; C57BL/10 and +/+ mice. Larval growth rates in all mice were similar. BALB/C and Dh/+ mice only were examined later than four weeks after infection. The yield of adult worms from BALB/C was 7.5% at 16 weeks and from Dh/+ 4.2% at 21 weeks. Microfilariae were present in the peritoneal fluids but not the blood of some mice harbouring both adult male and female worms.
D000818:Animals; D002009:Brugia / Q000254:growth & development*; D005368:Filariasis / Q000469:parasitology; D005370:Filarioidea / Q000254:growth & development*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000469:parasitology*; D008809:Mice, Inbred C3H / Q000469:parasitology; D008810:Mice, Inbred C57BL / Q000469:parasitology; D008808:Mice, Inbred CBA / Q000469:parasitology; D008815:Mice, Inbred Strains / Q000469:parasitology*; D013154:Spleen / Q000002:abnormalities