Influence of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidaz ole difumarate (KB-2413), a new antiallergic, on ciliary movement.
Influence of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazol e difumarate (KB-2413), a new antiallergic agent, on tracheal ciliary movement of pigeons and its local anaesthetic effect were investigated in comparison with reference drugs. KB-2413 (0.3 and 3 mg/kg i.v.) did not affect ciliary movement, but ketotifen, diphenhydramine, chlorpheniramine, lidocaine and tetracaine showed a significantly inhibitory effect on ciliary movement at a dose of 3 mg/kg i.v. KB-2413 (4% solution) did not inhibit corneal reflex in guinea pigs, but ketotifen, diphenhydramine and chlorpheniramine inhibited corneal reflex at 1%, 1% and 4% solution, respectively. KB-2413 (5 X 10(-4) mol/l) did not inhibit action potentials of desheathed frog sciatic nerve fiber, but ketotifen, chlorpheniramine and diphenhydramine inhibited significantly action potentials at 5 X 10(-4) mol/l. These results suggested that KB-2413 did not influence tracheal ciliary movement because of having no local anaesthetic effect.
D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D002923:Cilia / Q000187:drug effects*; D010856:Columbidae; D005260:Female; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D011892:Rana catesbeiana; D012584:Sciatic Nerve / Q000187:drug effects; D014132:Trachea / Q000187:drug effects*
D000779:Anesthetics, Local; D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D008012:Lidocaine; C043345:emedastine