[Mediators in the mechanism of the neurotropic action of thyroliberin].
The involvement of acetylcholine (ACH), noradrenaline, gamma-aminobutyric acid (GABA) in the mechanism of neurotropic action of thyrotropin-releasing hormone (TRH) was studied by pharmacological analysis. Spontaneous locomotor activity of mice and antagonism to hexenal according to the awakening effect in mice were used as parameters of the physiologic action of TRH. Agonists and antagonists of appropriate neurotransmitters were employed for pharmacological analysis. TRH appeared to bean antagonist of atropine and physostigmine by locomotor activity and hypnotic effect of hexenal and to be an agonist of phenylephrine, isadrin, amphetamine and an antagonist of phentolamine and propranolol as shown by behavioral tests. According to the same tests TRH was found to be an antagonist of muscimol and an agonist of bicuculline. Thus, it may be assumed that ACH, NA and GABA are involved in TRH mechanism of action.
D000818:Animals; D004347:Drug Interactions; D006591:Hexobarbital / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors
D018377:Neurotransmitter Agents; D013973:Thyrotropin-Releasing Hormone; D006591:Hexobarbital
Mediatroy v mekhanizme neĭrotropnogo deĭstviia tiroliberina.