Elevated motilin levels in patients treated with antidepressant and neuroleptic drugs.
Constipation is a frequent effect of treatment with antidepressant and neuroleptic drugs as a result of interference with neuronal control of colonic muscular activity. Motilin, a circulating peptide, is involved in induction of myoelectric complexes in the colon. Significantly elevated circulating basal motilin levels were found in patients receiving tricyclic antidepressant drugs, mean 128 +/- 33 pmol/l (control 48 +/- 6 pmol/l) or neuroleptic therapy, mean 213 +/- 29 pmol/l (control 87 +/- 8 pmol/l).
D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D005768:Gastrointestinal Hormones / Q000097:blood*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D009037:Motilin / Q000097:blood*
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D005768:Gastrointestinal Hormones; D009037:Motilin