title: A brief history of depot neuroleptics.
abstract: The development of phenothiazines used to treat psychotic states, and later of long-acting injectable forms, is discussed. Considerations affecting the clinical use of these drugs, including patient compliance and relapse, are reviewed briefly. The depot neuroleptics appear particularly useful for noncompliant, forgetful, and treatment-resistant patients.
mesh_terms: D014150:Antipsychotic Agents / Q000266:history* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D049673:History, 20th Century; D006801:Humans; D010349:Patient Compliance; D010640:Phenothiazines; D011618:Psychotic Disorders / Q000188:drug therapy / Q000523:psychology; D012008:Recurrence
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D010640:Phenothiazines