Raised transmembrane oxalate flux in red blood cells in idiopathic calcium oxalate nephrolithiasis.
Red-blood-cell transmembrane oxalate flux was measured in a group of patients with idiopathic calcium oxalate nephrolithiasis and in normal controls. The mean transmembrane oxalate flux rate was significantly higher in stone-forming patients than in controls (0.93 +/- SD 0.31/min vs 0.29 +/- 0.11/min). 80% of stone-forming patients showed raised (greater than 2SD above the mean in controls) transmembrane oxalate flux. Anomalous cellular oxalate transport may be an important pathogenetic factor in calcium oxalate nephrolithiasis.
D000328:Adult; D001692:Biological Transport; D002129:Calcium Oxalate; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000097:blood*
D010070:Oxalates; D002129:Calcium Oxalate