Cross induced coagulations between human and crustacean clotting factors. Considerations on the clotting processes.
1. Cross induced coagulations show that human factor XIII and crustacean coagulin are to some extent functionally equivalent and may be substituted for each other. 2. In crustacea, fibrinogen and coagulin appear as in situ activated products since they are both able to react with non-activated human clotting factors. 3. The coagulin catalyzed transamidation which stabilizes the clot and renders it insoluble in 1-5% monochloroacetic acid solutions seems to be the basic reaction of the clotting process in the animals in which coagulation occurs. 4. The possibility of a two step clotting in crustacea is discussed.
D000217:Acyltransferases / Q000502:physiology; D000818:Animals; D001777:Blood Coagulation; D003386:Brachyura / Q000502:physiology*; D005176:Factor XIII / Q000502:physiology*; D005260:Female; D005340:Fibrinogen / Q000502:physiology; D006801:Humans; D008297:Male; D013045:Species Specificity; D013925:Thromboplastin / Q000502:physiology*; D011503:Transglutaminases
D005340:Fibrinogen; D005176:Factor XIII; D013925:Thromboplastin; D000217:Acyltransferases; D011503:Transglutaminases