[Effects of zotepine, a psychotropic agent, on the serum uric acid level of inpatients at a psychiatric hospital].
Serum uric acid levels were examined and compared to diagnostic groups of inpatients of a mental hospital. An action lowering serum uric acid level of zotepine was further evaluated in those patients.


RESULTS
(1) In patients receiving some kind of psychotropic drugs, except for zotepine, mean serum uric acid level of patients with epilepsy in both sexes was significantly lowered in comparison with that of schizophrenia. Mean serum uric acid levels of male and female patients with alcoholism and organic brain disease were higher than that of schizophrenia without any statistical significance. (2) Mean serum uric acid level of patients treated with various psychotropic drugs, except for zotepine, was higher than that of patients receiving zotepine. (3) Zotepine decreased serum uric acid level parallel with its dosage (r=0.70, p less than 0.001) with a mean reduced rate of 54.1% (p less than 0.001), when serum uric acid levels of 32 patients were examined 3 times over 3 months before and during zotepine administration, respectively. (4) Maximum reduction of serum uric acid level occurred in 3-6 days following zotepine application. Controversely, it takes about 4 weeks to recover baseline level of serum uric acid after stopping zotepine administration. (5) Zotepine had no significant effect not only on the results of creatinine clearance test, but also on BUN level. However, it significantly increased level of uric acid clearance, and rate between uric acid clearance and creatinine clearance. The rate of uric acid clearance vs creatinine clearance correlated with the dosage of zotepine given. Zotepine is thought to decrease serum uric acid level via selective blocking of tubular reabsorption of uric acid in the kidney.
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003404:Creatinine / Q000652:urine; D003988:Dibenzothiepins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000097:blood*; D008875:Middle Aged; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood* / Q000652:urine
D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D014527:Uric Acid; D003404:Creatinine; C022172:zotepine