Inhibition of pancreatic hormone secretion by somatostatin-28 and somatostatin-14 in man.
The effects of a 210 min infusion of 1.8 nmol/kg somatostatin-14 (SS-14), somatostatin-28 (SS-28), and vehicle (Haemaccel) alone, on arginine- and insulin-stimulated release of pancreatic hormones were tested in 5 normal male subjects. Arginine administered at 30-60 min induced an increase in plasma glucose concentrations which was enhanced by SS-14 and further increased by SS-28. SS-28 was more effective than SS-14 in suppressing the arginine-induced secretion of insulin. Arginine-stimulated and insulin-stimulated (at 120 min) glucagon release was equally suppressed by SS-14 and SS-28, as was insulin-stimulated pancreatic polypeptide secretion. At the end of the SS-14 infusion the mean plasma somatostatin level was approximately 28% of that which occurred during the SS-28 infusion. The results are discussed in relation to similar studies in vitro and in vivo in laboratory animals and to a possible role of the two forms of SS in carbohydrate homeostasis.
D000328:Adult; D001120:Arginine / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D050260:Carbohydrate Metabolism; D005934:Glucagon / Q000097:blood; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010187:Pancreatic Hormones / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000097:blood / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*; D053561:Somatostatin-28; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D010187:Pancreatic Hormones; D010906:Pituitary Hormone-Releasing Hormones; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D013973:Thyrotropin-Releasing Hormone; D053561:Somatostatin-28; D005934:Glucagon; D001120:Arginine