Some biochemical aspects of phosphine action and resistance in three species of stored product beetles.
The inhibitory effects of phosphine on cytochrome-c oxidase and catalase have been investigated. Cytochrome-c oxidase is inhibited by treatment of insect homogenates in vitro. Catalase is inhibited in susceptible insects poisoned with phosphine in vivo. Resistant insects absorb less phosphine than susceptibles.
D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors*; D001517:Coleoptera / Q000201:enzymology*; D004351:Drug Resistance; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D010720:Phosphines / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity
D010720:Phosphines; D002374:Catalase; D003576:Electron Transport Complex IV