title: [Measurement of serum activity in short and long-term application of various hormonal contraceptives].
abstract: The influence of several oral contraceptives on various serum enzymes was tested during a short-term and a prolonged (24 therapeutic cycles) application period. A total of 8,790 examinations was performed in 211 females, each patient being examined up to 8 times during the cycles 0, 1, 3, 6, 12, 18, 24 and the first cycle following termination of oral contraception. Since sufficiently sensitive steroid-dependent makers are lacking, it cannot be dispensed with determining the serum enzymes gamma-GT, GPT, GOT, and LAP altogether, in order to detect early damage of the liver.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004798:Enzymes / Q000097:blood*; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D004798:Enzymes; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
vernacular_title: Serumaktivitätsmessungen bei Kurz- und Langzeitapplikation verschiedener hormonaler Kontrazeptiva.