Central nervous system sites of action of bombesin and somatostatin to influence plasma epinephrine levels.
Bombesin acts within dog brain to increase plasma concentrations of glucose and epinephrine. Microinjection of bombesin into a variety of brain regions demonstrates that this peptide's site of action is within the dorsal hypothalamic area. Microinjection of the somatostatin analog, desAA1,2,4,5,12,13 [D-Trp8]-somatostatin (ODT8-SS) into the dorsal hypothalamic area but not into other brain areas prevents bombesin-induced elevation of plasma glucose and epinephrine. Thus bombesin and ODT8-SS act within specific brain areas to influence plasma concentrations of glucose and epinephrine.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001839:Bombesin / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D001931:Brain Mapping; D004285:Dogs; D004837:Epinephrine / Q000097:blood*; D007034:Hypothalamus, Posterior / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D013004:Somatostatin / Q000494:pharmacology* / Q000031:analogs & derivatives
D001786:Blood Glucose; D010446:Peptide Fragments; D010455:Peptides; D013004:Somatostatin; C017583:somatostatin, octapeptide-Trp(8)-; D001839:Bombesin; D004837:Epinephrine