title: Hematopoietic microenvironment transfer by stromal fibroblasts derived from bone marrow varying in cellularity.
abstract: Autologous fibroblast derivatives of red and yellow marrow of rabbits were shown to differ in their capability to transfer a hematopoietic microenvironment upon implantation under the renal capsule. Although a heterotopic ossicle formed in each instance, the quality of the associated medullary tissue mirrored the quality of the bone marrow used to generate the stromal fibroblasts. Thus, fibroblasts cultured from a cellular marrow produced a stroma with numerous hematopoietic foci whereas those cultured from a severely hypocellular marrow produced a stroma with mainly fat cells. The results with 21 implants point to a transmittable regulatory role of a class of stromal fibroblasts.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002450:Cell Communication; D002452:Cell Count; D002478:Cells, Cultured; D005269:Femur / Q000166:cytology; D005347:Fibroblasts / Q000502:physiology / Q000637:transplantation; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D011817:Rabbits; D013977:Tibia / Q000166:cytology