Evidence for a glycinergic cortico-lateral hypothalamic inhibitory pathway in the rat.
To determine the neurotransmitter involved in the frontal cortex (FC)-lateral hypothalamic (LHA) inhibitory pathway, the effects of transmitter candidates and their antagonists on FC-evoked inhibitions in LHA neurons were analyzed using multibarrel iontophoretic and extracellular recording methods. The result suggests that glycine is involved in this inhibitory pathway.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001931:Brain Mapping; D005625:Frontal Lobe / Q000502:physiology*; D005998:Glycine / Q000502:physiology*; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects
D018377:Neurotransmitter Agents; D013331:Strychnine; D005998:Glycine; D001640:Bicuculline