title: Postnatal development of the mixed function oxidase system in nestling barn owls and baby chicks and induction of this system in the mature forms by Aroclor 1254.
abstract: Postnatal changes in content and activity of the mixed-function oxidase system in nestling barn owls and baby chicks showed the following: 1. Increase in liver weight in both. 2. Significantly higher cytochrome P-450 level in 1-day old chicks but lower in 1-day old owls than at any other age. 3. Ratio of cytochrome b5 to P-450 was lower than one in nestling owls but higher than one in chicks. 4. Aroclor 1254 (PCBs) increased the level and catalytic activity of cytochrome P-450 more in the owl than in the chick. 5. The ratio 455:430 nm characteristic of ethylisocyanide binding was not altered in the barn owl due to PCB treatment but changed significantly in the treated chicken.
mesh_terms: D000375:Aging; D000818:Animals; D001140:Aroclors / Q000494:pharmacology*; D001717:Birds / Q000254:growth & development* / Q000378:metabolism; D002645:Chickens / Q000254:growth & development* / Q000378:metabolism; D020111:Chlorodiphenyl (54% Chlorine); D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D004579:Electron Transport / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*
chemical_list: D001140:Aroclors; D003573:Cytochrome b Group; D020111:Chlorodiphenyl (54% Chlorine); D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases