Influence of beta blockade on gastric acid secretion and changes in gastric mucosal blood flow before and after parietal cell vagotomy in dogs and man.
The aim of the present study was, in paired experiments in dogs, to examine the effect of beta-receptor blockade on gastric acid secretion and mucosal blood flow before and after parietal cell vagotomy (PCV). The secretory response to pentagastrin was reduced after vagotomy. beta-Adrenergic blockade had no effect on pentagastrin-stimulated gastric acid secretion before PCV, but after PCV beta blockade caused a modest increase in acid secretion, mediated mainly by the beta 2 receptors. A similar trend was seen in man. A marked increase in mucosal blood flow occurred 30 min after propranolol and was followed by a late decrease. One may conclude that a modest beta-adrenergic tone, which reduces secretion, becomes manifest after vagal denervation and that an increase in the ratio between mucosal blood flow and acid secretion was induced by the PCV. This increase cannot be explained as a beta-receptor-mediated effect.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000818:Animals; D004285:Dogs; D004809:Ephedrine / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D014628:Vagotomy; D014629:Vagotomy, Proximal Gastric
D000319:Adrenergic beta-Antagonists; C004380:H 35-25; D011433:Propranolol; D010418:Pentagastrin; D004809:Ephedrine; D011217:Practolol