title: Effect of somatostatin on liver blood flow in the rat.
abstract: The effect of portal and systemic intravenous boluses of somatostatin on total liver blood flow in rats was studied using the xenon-133 clearance technique. No change in liver blood flow was found when somatostatin was delivered into the portal circulation, but there was a significant reduction in liver blood flow when somatostatin was delivered into the systemic venous circulation. The results suggest that somatostatin exerts its effect on liver blood flow through the pre-hepatic splanchnic circulation rather than directly on the portal vein.
mesh_terms: D000818:Animals; D008102:Liver Circulation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D013004:Somatostatin