Synthesis and neuroleptic activity of N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfonamidobenzamide s.
A series of some novel N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamides involving replacement of the sulfamoyl group in sulpiride with a sulfonamido group was synthesized and tested for dopamine receptor blockade. In comparison with sulpiride, several compounds were considerably more potent than sulpiride as dopamine receptor blockers. The structure-activity relationships are discussed.
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis*; D001549:Benzamides / Q000138:chemical synthesis*; D004285:Dogs; D051379:Mice; D011759:Pyrrolidines / Q000138:chemical synthesis*; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D014150:Antipsychotic Agents; D001549:Benzamides; D011759:Pyrrolidines; D013469:Sulpiride