Effect of 1-DOPA on calcitonin secretion by thyroid C cells.
After administering 1-DOPA for 7 d a decreased number of secretory granules as well as pronounced rough endoplasmic reticulum and Golgi apparatus were noted in C cells. A single dose of 1-DOPA did not inhibit C cell stimulation induced by a single dose of calcium gluconate. On the other hand, parallel administration of alpha-methyl-DOPA and calcium gluconate did not decrease the number of C cell secretory granules, which were observed after administration of calcium gluconate alone. The data suggest that the presence of DOPAmine (formed the 1-DOPA) in the secretory granules is a prerequisite for normal functioning of secretory processes in thyroid C cells.
D001078:APUD Cells / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D000818:Animals; D002116:Calcitonin / Q000378:metabolism*; D002125:Calcium Gluconate / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006168:Guinea Pigs; D007980:Levodopa / Q000494:pharmacology*; D008750:Methyldopa / Q000494:pharmacology; D008854:Microscopy, Electron; D051381:Rats; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D007980:Levodopa; D008750:Methyldopa; D002116:Calcitonin; D002125:Calcium Gluconate