Reduction of calcium currents in identified neurons of Helix pomatia: intracellular injection of D890.
The actions of intracellularly applied D890 on membrane currents of the identified neurons B1, B2 and B3 of Helix pomatia were investigated. The TTX-resistant component of the inward current, the inward currents in Na+-free sucrose solution and in Ca2+-free Ba2+ solution were reduced. In Ca2+-free Co2+ solution the inward current was not affected. The late outward currents were strongly reduced. In solutions containing 20 mmol/l NiCl2 the remaining parts of these currents were blocked only to a lesser extent. The early outward current remained unchanged. It is concluded that intracellularly applied D890 mainly exerts its effects on the calcium current.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005711:Gallopamil / Q000031:analogs & derivatives* / Q000494:pharmacology; D006372:Helix, Snails / Q000378:metabolism*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014700:Verapamil / Q000031:analogs & derivatives*
D007473:Ion Channels; D005711:Gallopamil; C041386:D 890; D012964:Sodium; D014700:Verapamil; D002118:Calcium