[Inhibitory action of histamine on the isolated rat uterus].
1. The present work investigates in vitro the inhibitory dose-response curves to histamine, 4-methyl-histamine and 2-pyridylethylamine in depolarized (KCl 37 mM) uterus from estrogenous sensitized rats. 2. Dose-response curves for the various agonists were obtained in the absence and presence of selective histaminergic (clemizole and cimetidine) and adrenergic (propranolol and reserpine) blocking drugs. 3. Histamine and 4-methyl-histamine, but not 2-pyridylethylamine, produced dose-dependent relaxations of the uterus. 4. Neither clemizole nor propranolol displaced the inhibitory dose-response curves for histamine. 5. After adrenergic blockade with either propranolol or reserpine, cimetidine produced a rightward displacement of the dose-response curves to histamine. 6. Theses results suggest that the inhibitory effect of histamine is mediated through activation of H2 histamine uterine receptors.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008761:Methylhistamines / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*
D001562:Benzimidazoles; D008761:Methylhistamines; D011725:Pyridines; C025566:4-methylhistamine; D011189:Potassium Chloride; D002927:Cimetidine; D006632:Histamine; D012110:Reserpine; D011433:Propranolol; C006183:2-(2-aminoethyl)pyridine
Action inhibitrice de l'histamine sur l'utérus isolé de ratte.