Antiviral activity of enzymatically oxidized caffeic acid against herpesvirus hominis type 1 and type 2.
The cytotoxicity and antiviral activity of the caffeic acid oxidation product (KOP), a higher molecular polyphenolic compound of strong antiviral activity against herpesvirus hominis type 1 and type 2 (HVH 1, HVH 2), were tested in 6 cell cultures: rabbit kidney primary cells (RKP), rabbit testis primary cells (RTP), primary human embryo lung fibroblasts (LF), calf testis primary cells (CTP), FL- and HEp-2 cells. A marked inhibitory effect on the multiplication of HVH 1 and 2 has been observed in all cell systems at non-cytotoxic concentrations of 0.1-20 micrograms/ml KOP. The adsorption of the virus to cell surface was the most KOP-sensitive phase of herpesvirus multiplication cycle.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002109:Caffeic Acids / Q000494:pharmacology*; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002934:Cinnamates / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology
D000998:Antiviral Agents; D002109:Caffeic Acids; D002934:Cinnamates