Differential inhibition of mitochondrial respiratory control by N-1-substituted, 3-,4-substituted pyridinium halides.
Several N-1-alkyl-, 3-, and 4-carbamidopyridinium halides were synthesized and determined to be inhibitors of mitochondrial oxidative phosphorylation. L-Glutamate respiration was most depressed by N-1-dodecylpyridinium bromide whereas succinate respiration was most depressed by N-1-dodecylisonicotinamide bromide. Combination of inhibitors with mitochondrial sites may involve lipophilic interactions as modified by steric restrictions.
D000818:Animals; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D009536:Niacinamide / Q000031:analogs & derivatives*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011726:Pyridinium Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
D005971:Glutamates; D011726:Pyridinium Compounds; D013386:Succinates; C001524:Laurosept; D009536:Niacinamide; D018698:Glutamic Acid; D019802:Succinic Acid