A10 lesion and passive avoidance latency: correlation with limbic tyrosine-hydroxylase-activity.
Experiments were carried out with female tree-shrews (Tupaia belangeri). Following 6-hydroxydopamine injections into the ventral tegmental area, considerable variations in tyrosine-hydroxylase activity in the respective target regions of the A10 area occurred. Depletion of the THY-activity in the septum (SE), the entorhinal cortex (ECO), the frontal cortex and the basal ganglia correlated with an impairment in the performance of a passive avoidance task (indicated by testing 24 hours postshock). Partial correlation analysis revealed that the variations of THY-activity in the SE and ECO are primarily related to this failure in passive avoidance acquisition.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D008032:Limbic System / Q000201:enzymology*; D013238:Stereotaxic Techniques; D013681:Tegmentum Mesencephali / Q000502:physiology*; D014418:Tupaiidae / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D006892:Hydroxydopamines; D014446:Tyrosine 3-Monooxygenase