Prolactin secretion response to TRH stimulation in acute and chronic schizophrenic patients under neuroleptic treatment.
Prolactin (PRL) serum levels in a group of patients with acute schizophrenia (AS) and in a group of patients with chronic schizophrenia (CS) have been investigated in order to differentiate the dopaminergic sensitivity in response to chlorpromazine (CPZ) treatment. AS patients show both a greater dopaminergic sensitivity to CPZ and a stronger response in PRL secretion to TRH stimulation after a 14-day CPZ treatment.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002746:Chlorpromazine / Q000494:pharmacology* / Q000627:therapeutic use; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D011389:Prolactin Release-Inhibiting Factors / Q000097:blood; D011954:Receptors, Dopamine / Q000187:drug effects; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D011389:Prolactin Release-Inhibiting Factors; D002746:Chlorpromazine