Effect of DDE on the Ca metabolism of the duck eggshell gland and its subcellular fractions; relation to the functional stage.
Administration of DDE to Indian Runner ducks (Anas platyrhynchos var.) reduced the eggshell index by 28% and the calcium content of the secreted fluid in the shell gland by 25%. DDE inhibited the functional decrease of the calcium content of the gland cells that occurred during eggshell formation. DDE reduced the functional increase in the ATP-dependent binding of Ca2+ to a microsomal subfraction FIII prepared from Ca-secreting glands forming an eggshell. In subfraction FI the Ca2+ binding was decreased by DDE even when the gland contained a mature shell. FIII probably contained calcium-secreting granules, whereas FI contained plasma membrane fragments of the gland cells.
D000818:Animals; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D003633:Dichlorodiphenyl Dichloroethylene / Q000494:pharmacology*; D004372:Ducks; D004528:Egg Shell; D005088:Exocrine Glands / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009092:Mucous Membrane / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism*
D003633:Dichlorodiphenyl Dichloroethylene; D002118:Calcium