The mammillary body is a potential site of antianxiety action of benzodiazepines.
The present study was designed to examine the anticonflict action of benzodiazepines injected into the mammillary body (MB) using the rat conflict-punishment procedure. Diazepam 20 micrograms/microliters, chlordiazepoxide 60 micrograms/microliters and midazolam 30 micrograms/microliters, bilaterally injected into the MB, produced a significant increase in the punished responses without changes in the unpunished responses. These findings have demonstrated for the first time that the MB could be a potential site of antianxiety action of benzodiazepines.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D007700:Kinetics; D008297:Male; D008326:Mammillary Bodies / Q000187:drug effects / Q000502:physiology*; D008874:Midazolam; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D002707:Chlordiazepoxide; D003975:Diazepam; D008874:Midazolam