[Effect of neuroleptics on foot-pedal self stimulation from the ventral tegmentum mesencephali in rats and its correlation with cataleptogenic action].
Experiments on rats have shown that droperidol, fluorophenazine, haloperidol, triphtazine, aminazin, thioridazin and clozapin are capable to reduce pedal self-stimulation from the ventral tegmen of the midbrain, which is not related to the cataleptogenic action of the neuroleptics or to their effect on the actuating motor mechanisms but is a consequence of the action on the emotional-positive reinforcement system. A significant positive correlation was disclosed between the ability of the neuroleptics given in effective doses to reduce pedal self-stimulation from the ventral tegmen and their cataleptogenic action.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced*; D002746:Chlorpromazine / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D004329:Droperidol / Q000494:pharmacology; D005476:Fluphenazine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D013681:Tegmentum Mesencephali / Q000502:physiology*; D013881:Thioridazine / Q000494:pharmacology; D014268:Trifluoperazine / Q000494:pharmacology
D014150:Antipsychotic Agents; D014268:Trifluoperazine; D003024:Clozapine; D006220:Haloperidol; D013881:Thioridazine; D004329:Droperidol; D005476:Fluphenazine; D002746:Chlorpromazine
Vliianie neĭroleptikov na reaktsiiu pedal'noĭ samostimuliatsii krys s ventral'noĭ pokryshki srednego mozga e ego korreliatsiia s ikh kataleptogennym deĭstviem.