title: Glucose utilization in the auditory system: cochlear dysfunctions and species differences.
abstract: Deoxyglucose uptake in peripheral auditory tissues and inferior colliculus of the young CBA or C57BL/6J mouse increases with intensity of an acoustic stimulus from 25 to 85 dBA and decreases from 85 to 115 dBA. In 36-month-old CBA and 9-month-old C57BL with sensorineural hearing loss the metabolic response to stimulation is attenuated 50% or more. Metabolic responses to stimuli are qualitatively and quantitatively different in the gerbil and in the guinea-pig. It is concluded that cochlear dysfunctions are characterized by abnormal evoked metabolism; and that the stimulus-response pattern varies with species.
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003051:Cochlea / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007759:Labyrinth Diseases / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains / Q000378:metabolism*
chemical_list: D003847:Deoxyglucose; D005947:Glucose