title: The mammalian metabolism of R-(-)-m-synephrine.
abstract: The metabolism of R-(-)-m-synephrine (administered orally and by inhalation in man and intraperitoneally in rats) was studied quantitatively by a gas chromatography-mass spectrometry-selected ion monitoring (g.c.-m.s.-s.i.m.) method using deuterated internal standards. When m-synephrine hydrochloride was administered orally to humans in normal dosage regimens four main metabolites were excreted in urine: (i) unconjugated m-hydroxymandelic acid (MHMA, 30%), (ii) m-hydroxyphenylglycol (MHPG) sulphate (6%), (iii) m-synephrine sulphate (47%) and (iv) m-synephrine glucuronide (12%). The comparable figures after inhalation of the drug were 24, 6, 56 and 5%. Intraperitoneal injection of m-synephrine into rats gave: unconjugated MHMA (5%), MHPG sulphate (35%), unconjugated m-synephrine (7%) and conjugates of m-synephrine (9%:4% as the glucuronide and 5% as the sulphate).
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000336:Aerosols; D000818:Animals; D001711:Biotransformation; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006018:Glycols / Q000652:urine*; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D008333:Mandelic Acids / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains; D013578:Synephrine / Q000008:administration & dosage / Q000652:urine*
chemical_list: D000336:Aerosols; D006018:Glycols; D008333:Mandelic Acids; C024037:3-hydroxymandelic acid; C034487:3-hydroxyphenyl glycol; D013578:Synephrine