Beta-adrenoceptor agonist responses in the skin and lungs of asthmatic subjects.
Concomitant intradermal injection of salbutamol inhibits histamine-induced weal volume in the skin of atopic asthmatic subjects and the degree of this inhibition (index of beta-adrenergic effect in the skin) correlates with the bronchodilator effect of inhaled salbutamol in the same subjects (index of beta-adrenergic effect in the lung).
D000318:Adrenergic beta-Agonists / Q000502:physiology*; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D004727:Endothelium / Q000187:drug effects*; D005541:Forced Expiratory Volume; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007271:Injections, Intradermal; D008168:Lung / Q000187:drug effects; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology; D010366:Peak Expiratory Flow Rate; D012138:Respiratory Therapy; D012882:Skin Tests; D014797:Vital Capacity
D000318:Adrenergic beta-Agonists; D006632:Histamine; D000420:Albuterol; D009638:Norepinephrine