Graft-versus-host disease after treatment for chronic granulocytic leukaemia in transformation.
Two patients with chronic granulocytic leukaemia in blast cell transformation treated with high-dose cytotoxic drugs and transfusion of cryopreserved chronic phase buffy coat stem cells developed a clinical and pathological syndrome that closely resembled graft-versus-host disease (GVHD). It was possible (1) that both patients had true GVHD resulting from transfusion of HLA-identical blood products, or (2) that both cases were examples of the 'pseudo-GVHD' seen by others following syngeneic transplants. The laboratory findings did not support one postulated pathogenetic mechanism for 'pseudo-GVHD'--namely a lack of suppressor T-lymphocytes.
D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007951:Leukemia, Myeloid / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014182:Transplantation, Autologous