title: [Somatostatin in a case of nesidioblastosis (author's transl)].
abstract: The authors report the case of a three-month-old infant presenting with hypoglycaemia. The etiology, i.e. nesidioblastosis, was asserted by simultaneous dosage of insulin and glucose and by histologic study of the pancreas. Initial therapy was a combination of diazoxide, continuous enteral alimentation and glucose injections. It's ineffectiveness led to an operative decision and 4/5 ths of the pancreas were removed. After a transitory improvement symptoms recurred. Data provided by studies of baseline levels and response to exogenous somatostatin then allowed to determine the correct dosage for treatment with long-acting somatostatin. The authors also discuss the importance of somatostatin in pathogenesis as well as for diagnosis and therapy of nesidioblasosis.
mesh_terms: D006801:Humans; D006946:Hyperinsulinism / Q000175:diagnosis / Q000209:etiology*; D007231:Infant, Newborn; D008297:Male; D010182:Pancreatic Diseases / Q000188:drug therapy / Q000473:pathology*; D013004:Somatostatin / Q000627:therapeutic use
chemical_list: D013004:Somatostatin
vernacular_title: Etude de la somatostatine dans un cas d'hyperinsulinisme sév 53ere par nésidioblastose.