Exclusion of cellular iron and reduced gamma-glutamyl transpeptidase activity in rat pancreas acinar cell hyperplastic nodules and adenomas induced by azaserine.
Rat acinar cells in the azaserine-induced hyperplastic nodules or adenomas in the siderotic pancreas produced by repeated iron injections were found to be resistant to iron accumulation. These iron-resistant acinar cell lesions coincided rather well with the lesions having markedly decreased activity of gamma-glutamyl transpeptidase. These properties of the acinar cells could be useful for the identification of early lesions in pancreatic carcinogenesis.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D001377:Azaserine / Q000633:toxicity*; D005290:Ferric Compounds / Q000494:pharmacology; D006651:Histocytochemistry; D006965:Hyperplasia; D007501:Iron / Q000378:metabolism*; D008297:Male; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives*; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D011230:Precancerous Conditions; D051381:Rats; D011912:Rats, Inbred ACI; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D005290:Ferric Compounds; D001377:Azaserine; D007501:Iron; D005723:gamma-Glutamyltransferase; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate