Acute myoglobinuric renal failure. A consequence of the neuroleptic malignant syndrome.
Neuroleptic malignant syndrome and acute myoglobinuric renal failure developed in three patients after they had received a combination of a major tranquilizer and a tricyclic antidepressant or after a large dose of haloperidol. Rhabdomyolysis was demonstrated by biochemical methods as well as by a muscle biopsy. Myoglobinuria was confirmed by radioimmunodiffusion and also was verified in a necropsy specimen. Dehydration and drug interaction with tricyclic antidepressants seem to be predisposing factors. Renal function recovered when the patient survived the acute episode, but neurologic sequelae persisted. Recommendations that may avert further cases are made.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003681:Dehydration / Q000150:complications; D005260:Female; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009212:Myoglobinuria / Q000139:chemically induced* / Q000175:diagnosis; D009422:Nervous System Diseases / Q000139:chemically induced; D013577:Syndrome
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D006220:Haloperidol