Study of mumps virus invasiveness in monkeys.
Invasiveness of mumps virus strains, differing in the degree of attenuation was studied in green and Macaca mulatta monkeys infected either into salivary glands or intramuscularly. Peripheral infection with all strains under study resulted in their penetration into CNS irrespective of the attenuation degree. Specific morphological changes were observed in the brain of monkeys as confirmed by detection of virus antigen using fluorescent antibodies (FA) staining. Morphological changes and time of virus antigen detection in the brain differed depending on the neurovirulence of the strains based on different degree of their attenuation.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000473:pathology; D002490:Central Nervous System / Q000382:microbiology; D005455:Fluorescent Antibody Technique; D008253:Macaca mulatta; D009107:Mumps / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D009109:Mumps virus / Q000254:growth & development* / Q000276:immunology / Q000472:pathogenicity; D010306:Parotid Gland / Q000382:microbiology; D012469:Salivary Glands / Q000473:pathology; D014774:Virulence
D000914:Antibodies, Viral; D000956:Antigens, Viral