title: An in-vivo-in-vitro correlation for the bioavailability of frusemide tablets.
abstract: The dissolution behaviour of four commercial and two experimental formulations of frusemide tablets has been investigated using the USP rotating basket apparatus and pH 5.0 buffer at 37 degrees C as the test medium. There is a linear relationship between the percentage dissolution in 30 min and the bioavailability relative to an oral solution of frusemide over the bioavailability range 76-97%. Predicted bioavailabilities differed by no more than 2% from the measured values.
mesh_terms: D001682:Biological Availability; D005665:Furosemide / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D013607:Tablets; D005665:Furosemide