Actions of angiotensin II and acetylcholine at the rabbit superior cervical ganglion.
A sucrose-gap recording technique was used to record the depolarizations produced by angiotensin II and by acetylcholine (ACh) in the isolated rabbit superior cervical ganglion (SCG). Angiotensin (0.9 microM-112.8 microM) produced small depolarizations, whereas ACh (5 microM-9 mM) produced large depolarizations in the rabbit SCG. Hexamethonium (0.7 microM) only slightly reduced the angiotensin-induced depolarizations, while it greatly decreased those produced by ACh. Isoprenaline (1 microM) greatly increased the depolarizations produced by angiotensin, while it only slightly decreased those produced by ACh. It was concluded that angiotensin produces only small depolarizations in the rabbit SCG. The depolarization produced by angiotensin may be attributed to a postsynaptic effect of the peptide, but the possibility that the peptide is acting via presynaptic mechanisms is not entirely ruled out in the rabbit SCG.
D000109:Acetylcholine / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D009435:Synaptic Transmission / Q000187:drug effects
D006584:Hexamethonium Compounds; D000804:Angiotensin II; D018738:Hexamethonium; D007545:Isoproterenol; D000109:Acetylcholine