title: Clinical effects of hyposensitization using a purified allergen preparation from Timothy pollen as compared to crude aqueous extracts from Timothy pollen and a four-grass pollen mixture respectively.
abstract: Most extracts used in hyposensitization are complex and ill-defined mixtures of a large number of antigenic components. A highly refined (purified) and well-characterized allergen preparation from Timothy pollen (Phleum pratense) is now available. This paper describes the results of hyposensitization for 3 years comparing the purified preparation Timothy N, the crude extract Timothy O and a four-grass mix in sixty patients with allergic rhinitis due to grass pollen. The sixty patients were randomized into three groups and compared with a control group not hyposensitized. All three groups showed a significant decrease in clinical symptoms compared with the control group. The Timothy N group had a significantly higher nasal tolerance shown by nasal challenge test after 3 years' treatment than the group treated with the crude extract (P = 0.05). In addition, the Timothy-N-treated patients needed significantly less antihistaminic medication than the patients having received the crude extract or the four-grass mix (P = 0.02 and P = 0.01, respectively).
mesh_terms: D000328:Adult; D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology / Q000592:standards; D003231:Conjunctivitis / Q000150:complications / Q000628:therapy; D003888:Desensitization, Immunologic / Q000379:methods*; D004306:Dose-Response Relationship, Immunologic; D004355:Drug Stability; D006634:Histamine H1 Antagonists / Q000008:administration & dosage; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D009297:Nasal Mucosa / Q000503:physiopathology; D009299:Nasal Provocation Tests; D010349:Patient Compliance; D006109:Poaceae / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D012647:Self-Assessment
chemical_list: D000485:Allergens; D006634:Histamine H1 Antagonists; D007073:Immunoglobulin E