Hydrochloric acid hydrolysis of bromazepam. Identification and relevance of some additional products.
With MS and NMR spectroscopic methods the structures of three additional by-products formed in the hydrochloric acid hydrolysis of bromazepam were established. Some attention was paid to the analytical relevance of the by-products and indications are given to perform the hydrolysis in such a way that one specific product can be obtained.
D014151:Anti-Anxiety Agents / Q000032:analysis; D001960:Bromazepam / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D008401:Gas Chromatography-Mass Spectrometry; D006851:Hydrochloric Acid; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy
D014151:Anti-Anxiety Agents; D006851:Hydrochloric Acid; D001960:Bromazepam