Biological activity of synthetic analogs of serum thymic factor.
A series of analogs of serum thymic factor (Facteur Thymique Sérique; FTS) devoid of C- and N-terminal few residues were synthesized and their ability to induce Thy-l (theta) antigen in vitro on mouse T lymphocyte precursors was examined. The pentapeptide moiety (Lys-Ser-Gln-Gly-Gly) seems to be important for the expression of agonistic activity. Some of the short chain peptides showed antagonistic properties. Synergistic activation by two inactive analogs was observed.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D002851:Chromatography, High Pressure Liquid; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012397:Rosette Formation; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D018800:Thy-1 Antigens; D013935:Thymic Factor, Circulating / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D013951:Thymus Hormones / Q000138:chemical synthesis*
D000596:Amino Acids; D000954:Antigens, Surface; D007202:Indicators and Reagents; D018800:Thy-1 Antigens; D013951:Thymus Hormones; D013935:Thymic Factor, Circulating