Evidence for a role of neurotransmitters in the mechanism of topical convulsant models.
In numerous studies on several species, alterations in putative neurotransmitters have been examined in a variety of topical models of epilepsy. The results of such studies provide evidence for alterations in the concentration of some neurotransmitters, alterations in the activity of synthetic and/or degradative enzymes, and alterations in uptake mechanisms and receptor density. The neurotransmitters for which the most consistent data are available include gamma-aminobutyric acid, acetylcholine, and glutamic and aspartic acids.
D000109:Acetylcholine / Q000502:physiology; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000502:physiology; D001921:Brain / Q000503:physiopathology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology; D004827:Epilepsy / Q000503:physiopathology*; D005971:Glutamates / Q000502:physiology; D018698:Glutamic Acid; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D012640:Seizures / Q000503:physiopathology*; D013654:Taurine / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005971:Glutamates; D018377:Neurotransmitter Agents; D013654:Taurine; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D000109:Acetylcholine; D004298:Dopamine; D009638:Norepinephrine