title: Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, Papio papio.
abstract: Antagonists of excitation induced by dicarboxylic amino acids have been evaluated for acute anticonvulsant activity in baboons, Papio papio, with photosensitive epilepsy. 2-Amino-7-phosphonoheptanoic acid, 1 mmol/kg, i.v., abolishes myoclonic responses for 5 h. Less prolonged protection is seen after cis-2,3-piperidine-dicarboxylic acid, 1-3.3 mmol/kg; 2-amino-5-phosphonovaleric acid, 1-3.3 mmol/kg; or glutamic acid diethyl ester, 1-3.3 mmol/kg. Toxic side-effects are prominent after the latter two compounds. Antagonists of excitation due to N-methyl-D-aspartate possess acute anticonvulsant activity in a wider range of models epilepsy.
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants; D005971:Glutamates / Q000494:pharmacology*; D010215:Papio; D010775:Photic Stimulation; D010875:Pipecolic Acids / Q000494:pharmacology*; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology; D014633:Valine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D000927:Anticonvulsants; D005971:Glutamates; D010875:Pipecolic Acids; C011829:glutamic acid diethyl ester; C029262:2,3-piperidinedicarboxylic acid; D015763:2-Amino-5-phosphonovalerate; D014633:Valine; C031231:2-amino-7-phosphonoheptanoic acid