title: Comparative study with oxmetidine and ranitidine on acid secretion and gastrin release in the dog.
abstract: The antisecretory potency of oxmetidine was compared with that of ranitidine for its action against gastric acid secretion induced by histamine and by 2-deoxy-D-glucose (2DG) in the conscious gastric-fistula dog. Oxmetidine, administered i.v. during histamine stimulation, was nearly as effective as ranitidine, with a similar duration of action, but it was about twice as potent as ranitidine against 2DG-stimulated acid secretion. In experiments with bombesin, both oxmetidine and ranitidine significantly decreased gastric acid secretion to a similar extent, without affecting plasma gastrin levels.
mesh_terms: D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D003847:Deoxyglucose / Q000494:pharmacology; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005755:Gastrins / Q000097:blood*; D006632:Histamine / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology*; D013268:Stimulation, Chemical
chemical_list: D005755:Gastrins; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D006632:Histamine; D011899:Ranitidine; D003847:Deoxyglucose; D001839:Bombesin; C027703:oxmetidine