Extracellular calcium ions modify the effects of Anemonia sulcata toxin (ATX II) in guinea-pig papillary muscles.
In isolated guinea-pig papillary muscle ATX II prolonged the action potential duration to a lesser extent at high extracellular Ca++-concentrations. This is interpreted as an interference of Ca++ with ATX II-binding sites.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D002118:Calcium / Q000494:pharmacology*; D003064:Cnidarian Venoms / Q000633:toxicity*; D004347:Drug Interactions; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*
D003064:Cnidarian Venoms; C028800:toxin II (Anemonia sulcata); D002118:Calcium