Specific [3H]-spiroperidol binding sites in human prefrontal cortex: potential site multiplicity and overall serotonin-like selectivity.
[3H]-Spiroperidol specifically binds at sites in human prefrontal cortex. The binding of this ligand is apparently anomalous at 37 degrees C, with a substantial loss of specific binding occurring between 5 and 40 min incubation. However, at 21 degrees C, this loss of binding is not observed even at 60 min. At 21 degrees C, [3H]-spiroperidol binding in human prefrontal cortex is apparently occurring at multiple sites or multiple affinity states of single classes of sites, or at a combination of both. The overall selectivity is predominantly serotonergic, rather than dopaminergic.
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D001665:Binding Sites; D002090:Butyrophenones / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008024:Ligands; D012701:Serotonin / Q000502:physiology; D013134:Spiperone / Q000378:metabolism*; D013696:Temperature; D014316:Tritium
D014150:Antipsychotic Agents; D002090:Butyrophenones; D008024:Ligands; D014316:Tritium; D012701:Serotonin; D013134:Spiperone