Metabolic effects of prenalterol in healthy volunteers.
The effect of the beta 1-adrenoceptor agonist prenalterol on the metabolic parameters glucose, lactate, free fatty acids and serum-insulin were studied in 8 healthy volunteers. Prenalterol was administered intravenously in geometrically increasing doses from 5 to 80 micrograms/kg. The only metabolic effect of prenalterol that could be proved was a significant dose-dependent rise in FFA-concentration. The stimulating effect of prenalterol on lipolysis was significant not only at the time points of maximal effect following each injection, but also 30 min later. Serum-insulin-concentration and glucose- and lactate-concentration failed, however, to show a significant rise after prenalterol administration. This behaviour is a strong indication of a beta 1-selectivity of prenalterol over the whole dose range given.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000097:blood*; D007773:Lactates / Q000097:blood*; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D011217:Practolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011294:Prenalterol; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007773:Lactates; D011294:Prenalterol; D011217:Practolol