[A new synthesis of somatostatin].
The synthesis of somatostatin by linking together Boc-Ala-Gly-Cys(Bzl)-Lys(Z)-Asn-Phe-NHNH2 and H-Phe-Trp-Lys[Z(pCl)]-Thr-Phe-Thr-Ser-Cys(Bzl)-OBzl is described. The two partial sequences were obtained from segments which in general are also used in preparing somatostatin analogues. The synthesis of the partial sequences was optimized. The intracerebroventricular application of the somatostatin thus obtained to rats produced an increase of the dopamine and serotonin contents in the striatum. The results achieved were identical with those realized with standard somatostatin (Serono).
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D007276:Injections, Intraventricular; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013004:Somatostatin / Q000138:chemical synthesis* / Q000494:pharmacology
D012701:Serotonin; D013004:Somatostatin; D004298:Dopamine
Eine neue Synthese von Somatostatin.