Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence.
In this double-blind comparison of propoxyphene napsylate (PN) 800 mg in two divided doses versus methadone 20 mg, methadone 10 mg or placebo methadone, it was found that PN: 1) did not alleviate withdrawal symptoms in patients previously maintained on methadone 20 mg; 2) produced a slightly overmedicated effect in the detoxified group of exmethadone patients; and 3) compared favorably to methadone 10 mg in suppressing withdrawal symptoms without producing evidence of overmedication in those patients previously stabilized on a methadone maintenance dose of 10 mg.
D000328:Adult; D011431:Dextropropoxyphene / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004311:Double-Blind Method; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D011897:Random Allocation; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy
D011431:Dextropropoxyphene; D008691:Methadone