title: Somatostatin-28 is an hormonally active peptide secreted into hypophysial portal vessel blood.
abstract: Somatostatin 14 and 28 (SS-14 and SS-28) have been measured in hypophysial portal blood of male Wistar rats. The concentration and total amount of SS released into portal blood were increased 6- to 7-fold by electrical stimulation of the median eminence. On HPLC, only two peaks of immunoreactivity were detected in extracts of portal plasma and these peaks corresponded with SS-14 and SS-28, respectively. The amount of SS-28 in portal plasma was, on a molar basis, similar or greater than that of SS-14 and this together with other evidence suggests that SS-28 is an hormonally active peptide.
mesh_terms: D000818:Animals; D008297:Male; D008473:Median Eminence / Q000502:physiology; D010902:Pituitary Gland / Q000294:innervation / Q000378:metabolism*; D011498:Protein Precursors / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000097:blood*; D053561:Somatostatin-28
chemical_list: D011498:Protein Precursors; D013004:Somatostatin; D053561:Somatostatin-28