Endocrine dependence of prostatic cancer upon dihydrotestosterone and not upon testosterone.
Growth of the Dunning R3327-H prostatic adenocarcinoma, implanted in the rat, is inhibited by 6-methylene progesterone. This compound is a potent inhibitor of rat prostatic 5-alpha-reductase and in-vivo produced marked involution of the prostate. Thus the tumor requires dihydrotestosterone and not testosterone for growth.
D000230:Adenocarcinoma / Q000503:physiopathology*; D000818:Animals; D002478:Cells, Cultured; D013196:Dihydrotestosterone / Q000502:physiology*; D008297:Male; D009368:Neoplasm Transplantation; D009376:Neoplasms, Hormone-Dependent / Q000503:physiopathology*; D011374:Progesterone / Q000031:analogs & derivatives / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000503:physiopathology*; D051381:Rats; D013739:Testosterone / Q000502:physiology*
D013196:Dihydrotestosterone; C036790:6-methylene-4-pregnene-3,20-dione; D013739:Testosterone; D011374:Progesterone