Post-partum rubella immunisation: a controlled trial of two vaccines.
The effectiveness of two rubella vaccines (RA 27/3 and Cendehill) in women vaccinated post partum was compared. Significantly more women who received RA 27/3 gave satisfactory seroconversion responses than women who received Cendehill (97.6% vs 82.2%). This difference was reflected in the geometric mean titres (43.6 vs 17.0). More women who received RA 27/3 had minor side-effects, but the difference was not significant. The serological response to both vaccines was not affected by the concurrent administration of anti-D immunoglobulin. In view of these findings, the replacement of Cendehill vaccine with RA 27/3 vaccine for women vaccinated post partum should be considered.
D000914:Antibodies, Viral / Q000032:analysis*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage; D049590:Postpartum Period; D011247:Pregnancy; D011446:Prospective Studies; D011897:Random Allocation; D012409:Rubella / Q000517:prevention & control*; D012411:Rubella Vaccine; D012412:Rubella virus / Q000276:immunology
D000914:Antibodies, Viral; C008104:IgO; D007136:Immunoglobulins; D012411:Rubella Vaccine