Induction of cytosolic tyrosine aminotransferase by dexamethasone in organ culture of fetal human liver.
Total tyrosine aminotransferase activity in organ culture of fetal human liver is increased by 347% after 15 h incubation with 2 micro M of dexamethasone. Isoelectric focusing reveals that the increased activity is due to induction of cytosolic tyrosine aminotransferase (EC 2.6.1.5) while the activity of the nonspecific mitochondrial aspartate aminotransferase (EC 2.6.1.1) remains unchanged.
D001219:Aspartate Aminotransferases / Q000096:biosynthesis; D046508:Culture Techniques; D003600:Cytosol / Q000201:enzymology; D003907:Dexamethasone / Q000494:pharmacology*; D004790:Enzyme Induction; D005333:Fetus / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000196:embryology / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D003907:Dexamethasone; D001219:Aspartate Aminotransferases; D014444:Tyrosine Transaminase