[Effect of 2 new derivatives of imidazoline and their optical isomers on postsynaptic alpha adrenergic receptors in pithed rats].
The effects of the stereoisomers of two alpha adrenoceptor antagonists [S 10089 (Imidazolinyl-2)-2 benzocyclobutane and S 9871 (Imidazolinyl-2)-2 dihydro 2,3 benzofuran] were studied in pithed Rats. Vasoconstriction elicited via stimulation of alpha 1 adrenoceptors by cirazoline was antagonized, stimulation of alpha 2 adrenoceptors by azepexole was also antagonized by all these derivatives except (-) S 9871 which was ineffective on the pressor response of azepexole.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D013116:Spinal Cord / Q000502:physiology; D013237:Stereoisomerism
D000317:Adrenergic alpha-Antagonists; D001572:Benzofurans; D007093:Imidazoles; D011942:Receptors, Adrenergic, alpha; C042254:S 9871; C043651:2-benzocyclobutane-4,5-dihydro-1-H-imidazole
Action de deux nouveaux dérivés de l'imidazoline et de leurs isomères optiques sur les récepteurs adrénergiques alpha postsynaptiques du rat amyélé.