The effect of somatostatin on self-stimulation behavior in atropine- and methysergide-pretreated rats.
The effect of somatostatin on lateral hypothalamic self-stimulation was investigated in atropine- and methysergide-pretreated rats. Somatostatin markedly decreased the self-stimulation rate of the animals. Atropine in a dose which had no action on self-stimulation partly antagonized the effect of somatostatin. Methysergide potentiated the somatostatin-induced depression of self-stimulation behavior. These results suggest that the central cholinergic and serotoninergic systems may play a role in the somatostatin-induced inhibition of self-stimulation.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D008297:Male; D008784:Methysergide / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D013004:Somatostatin / Q000494:pharmacology*
D012701:Serotonin; D013004:Somatostatin; D001285:Atropine; D008784:Methysergide