Haemodynamic effects of beta-receptor blockade during acute administration and chronic treatment.
In early essential hypertension, an increase in cardiac output (CO) is seen in about two-thirds of the patients. In established essential hypertension, CO is usually normal or subnormal, while total peripheral resistance (TPR) is increased. Treatment with beta-adrenergic blocking agents accentuates these haemodynamic changes; in particular CO is further decreased. Comparison of the effects of beta-blockers with and without beta 1-selectivity and intrinsic activity reveals slight differences in the haemodynamic responses. Although none of the beta-blockers normalizes the haemodynamics, satisfactory blood-pressure reduction may be achieved at rest and during exercise with minimal side effects.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D013566:Sympathomimetics / Q000627:therapeutic use; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D013566:Sympathomimetics