[Indices of autoimmunity in schizophrenic patients with an unfavorable course after long-term treatment with neuroleptics].
The authors examined 176 patients with schizophrenia running an unfavourable course, treated with neuroleptics for a long time; 20 oligophrenics on prolonged neuroleptic therapy and 47 healthy subjects. The immunological status of the patients was characterized by high neutrophil damage in the presence of a complex of brain antigens, in particular those of the subcortical area (trunk and optic tuber), marked formation of hemolytic plaques, inhibition of spontaneous rosette-formation, low antithymic activity of the serum, and by a slightly elevated level of blood histamine. Administration of chlorpromazine in different concentrations led to a stimulation of plaque formation and inhibition of rosette-formation. The groups of patients with high and low responsiveness were distinguished.
D000961:Antilymphocyte Serum; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000209:etiology*; D001921:Brain / Q000276:immunology; D006462:Hemolytic Plaque Technique; D006632:Histamine / Q000097:blood; D006801:Humans; D007958:Leukocyte Count; D009504:Neutrophils / Q000276:immunology; D012559:Schizophrenia / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes
D000961:Antilymphocyte Serum; D014150:Antipsychotic Agents; D006632:Histamine
Pokazateli autoimmuniteta u bol'nykh s neblagopriiatnym techeniem shizofrenii, dlitel'no lechennykh neĭroleptikami.