Uraniosomes produced in cultured rabbit kidney cells by uranyl acetate.
Cultured rabbit kidney cells were exposed to uranyl acetate. This produced single-membrane-bound presumably lysosomal bodies (called 'uraniosomes') containing electron-dense crystals in the cultured cells. Similar crystalline deposits were seen in extracellular locations also. All uraniosomes and extracellular uranium deposits analyzed by electron-probe x-ray analysis were found to contain uranium, potassium, calcium and phosphorus. Traces of sulphur were detected in some but not all uraniosomes and extracellular uranium deposits.
D000818:Animals; D002118:Calcium / Q000032:analysis; D002478:Cells, Cultured / Q000187:drug effects; D005110:Extracellular Space / Q000032:analysis; D002479:Inclusion Bodies / Q000032:analysis / Q000648:ultrastructure*; D007668:Kidney / Q000187:drug effects*; D008247:Lysosomes / Q000648:ultrastructure; D008854:Microscopy, Electron; D010758:Phosphorus / Q000032:analysis; D011188:Potassium / Q000032:analysis; D011817:Rabbits; D013455:Sulfur / Q000032:analysis; D014501:Uranium / Q000494:pharmacology*
D010758:Phosphorus; D014501:Uranium; D013455:Sulfur; D011188:Potassium; D002118:Calcium