Surface proteins of radiation-induced and radiation leukemia virus-induced thymic lymphosarcomas in mice.
Thymic lymphosarcomas (TLS) were induced in C57BL mice by X-rays or by Radiation Leukemia Virus (RadLV) and their surface glycoproteins (gps) compared after cell-surface radioiodination and polyacrylamide gel electrophoresis (SDS-PAGE). All lymphocytic antigens tested (T200, 170/100, Thy-1) and proteins with apparent molecular weight (Mr) around 120,000 and 100,000 were present on all tumours, as well as retrovirus--encoded proteins but considerable variation in the Mr of several serologically-related proteins was observed. Therefore, the TLS in C57BL mice form a heterogeneous group, suggesting that T cells can be transformed at different stages of maturation. The possibility that transformation allows or even triggers differentiation is also entertained.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001345:Autoradiography; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009363:Neoplasm Proteins / Q000032:analysis*; D009374:Neoplasms, Experimental / Q000209:etiology / Q000378:metabolism; D009381:Neoplasms, Radiation-Induced / Q000378:metabolism*; D013601:T-Lymphocytes; D018800:Thy-1 Antigens; D014412:Tumor Virus Infections / Q000378:metabolism*; D014764:Viral Proteins / Q000032:analysis
D000954:Antigens, Surface; D006023:Glycoproteins; D009363:Neoplasm Proteins; D018800:Thy-1 Antigens; D014764:Viral Proteins