title: Relationship between systolic time interval measurements and the extent of regional ventricular asynergy in coronary artery disease.
abstract: Systolic time interval (STI) measurements were made in 44 patients with coronary artery disease: 38 had regional left ventricular (LV) asynergy, and the remaining 6 had normal ventricular contraction patterns on left ventricular angiography. There was a significant correlation between both the preejection period (PEP) (r = 0.70) and the PEP/LVET (LV ejection time) ratio (r = 0.66), with the extent of regional ventricular dysfunction measured quantitatively on the left ventricular angiogram (P less than 0.001). A PEP/LVET ratio greater than 0.50 was associated with ventricular asynergy involving more than 40% of the LV circumference at end diastole. STI measurements also correlated with ejection fraction but not with ventricular end diastolic pressure nor with the number of obstructed coronary arteries.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D003327:Coronary Disease / Q000503:physiopathology*; D004077:Digoxin / Q000494:pharmacology; D006352:Heart Ventricles; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D009200:Myocardial Contraction / Q000187:drug effects; D013599:Systole / Q000187:drug effects; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D004077:Digoxin