Buspirone: a potential atypical neuroleptic.
Buspirone produces a dose-dependent but short-lived elevation in striatal dopamine (DA) metabolites in the rat. In vitro, buspirone possesses an affinity similar to sulpiride for DA receptors (3H-spiperone). A moderate affinity for alpha 1 receptors was also observed while buspirone was inactive at alpha 2, beta, muscarinic and serotonin2 receptors. This pharmacological profile as well as previous behavioral data indicate that buspirone may be a potential "atypical" neuroleptic.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002065:Buspirone; D003024:Clozapine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism; D013469:Sulpiride / Q000494:pharmacology; D013997:Time Factors
D014150:Antipsychotic Agents; D011743:Pyrimidines; D011954:Receptors, Dopamine; D013469:Sulpiride; D003024:Clozapine; D006220:Haloperidol; D002065:Buspirone; D004298:Dopamine