Immunoglobulin allotype markers in gluten-sensitive enteropathy.
Immunoglobulin allotype markers and HLA-A, HLA-B, and HLA-DR locus antigens were determined in 30 White patients with gluten-sensitive enteropathy and 30 controls matched for age, ethnic background, and geographic origin. All patients lacking HLA-B8 and HLA-DR3 had the IgG (Gm) immunoglobulin heavy-chain phenotype Gm (f;n;b). Thus, in addition to major histocompatibility locus genes, it appears that genes linked to the immunoglobulin heavy-chain allotype locus on chromosome 14 may influence susceptibility in gluten-sensitive enteropathy.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000235:genetics*; D002901:Chromosomes, Human, 13-15; D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012306:Risk
D006680:HLA Antigens; D007126:Immunoglobulin Allotypes