N2O and urine methylmalonic acid in man.
The excretion of methylmalonic acid was measured and deoxyuridine suppression test (dU-test) was performed in 5 patients before and after 24 h of ventilation with nitrous oxide. The mean urinary 2-methylmalonic acid was increased from 90 to 320 mumol/24 h and the dU-tests became abnormal. These findings indicate that the 2 vitamin B-12 dependent enzymes, methylmalonyl-CoA-mutase and methione synthetase, are depressed by nitrous oxide.
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000502:physiology; D000769:Anesthesia, Inhalation; D003857:Deoxyuridine; D006801:Humans; D008314:Malonates / Q000652:urine*; D008764:Methylmalonic Acid / Q000652:urine*; D008765:Methylmalonyl-CoA Mutase / Q000502:physiology; D009609:Nitrous Oxide / Q000494:pharmacology*
D008314:Malonates; D008764:Methylmalonic Acid; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D008765:Methylmalonyl-CoA Mutase; D009609:Nitrous Oxide; D003857:Deoxyuridine