Clinical experiences with prenalterol as an antidote to Beta-adrenoceptor blockade.
The cases presented in this paper suggest that prenalterol is useful in the treatment of myocardial depression due to beta-blockade. According to its pharmacological properties, prenalterol might even be the drug of choice in these situations. It is wellknown that massive beta-blocker overdosage may be difficult to manage and as the therapeutic guidelines in these cases have not yet been definitely stated, it is obvious that prenalterol in this context will be of utmost importance. What remains to be solved is the dosage level. So far, experience has shown that high doses, widely exceeding the recommended initial dose of 50-100 micrograms/kg, are necessary to restore normal circulation in massive beta-blocker overdosage.
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000319:Adrenergic beta-Antagonists / Q000037:antagonists & inhibitors*; D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000009:adverse effects; D006328:Cardiac Catheterization / Q000009:adverse effects; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008790:Metoprolol / Q000037:antagonists & inhibitors; D009203:Myocardial Infarction / Q000188:drug therapy; D011217:Practolol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011294:Prenalterol; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000633:toxicity
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D008790:Metoprolol; D011294:Prenalterol; D011217:Practolol