Aculeximycin, a new antibiotic from Streptosporangium albidum. II. Isolation, physicochemical and biological properties.
A new larvicidal antibiotic, aculeximycin, was found in the culture broth of an actinomycete identified as Streptosporangium albidum. Aculeximycin was isolated from the culture filtrate by adsorption on a Diaion HP-20 column and successive elution with acidic aqueous acetone. It was extracted from the concentrated active fraction with 1-butanol and subjected to column chromatography on a Sephadex LH-20 column. Aculeximycin exhibited strong larvicidal activity against mosquito larvae as well as antimicrobial activities against Gram-positive and Gram-negative bacteria, yeasts and molds.
D000192:Actinomycetales / Q000032:analysis*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D009033:Culicidae / Q000254:growth & development; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects; D007814:Larva / Q000187:drug effects; D018942:Macrolides; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D018942:Macrolides; C039610:aculeximycin