Reversible azoospermia induced by the anabolic steroid 19-nortestosterone.
Esterified 19-nortestosterone, an anabolic steroid which has been in clinical use for over 20 years, was administered intramuscularly to five healthy volunteers in doses of 100 mg/week for 3 weeks followed by 200 mg/week for a further 10 weeks. Azoospermia occurred 7 to 13 weeks after initiation of treatment and persisted for 4-14 weeks after the last injection. Serum gonadotropin and testosterone levels were reduced, but androgenic effects were maintained as indicated by unchanged libido and potency. No serious side-effects were noted. 19-nortestosterone appears to be a potential agent for male fertility control.
D000328:Adult; D045930:Anabolic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D004920:Erythropoiesis / Q000187:drug effects; D006801:Humans; D007989:Libido / Q000187:drug effects; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009845:Oligospermia / Q000139:chemically induced*; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects
D045930:Anabolic Agents; D003272:Contraceptive Agents, Male; C034345:19-nortestosterone 4-hexoxyphenylpropionate; D009277:Nandrolone