A comparison of the effects of N-methyl-D-aspartate and quinolinate on central neurones of the rat.
The apparent potencies of quinolinate, N-methyl-D-aspartate (NMDA) and quisqualate as excitants administered microelectrophoretically to single central neurones have been compared. In the cerebral cortex of rats NMDA has about 10% and quinolinate about 1% of the potency of quisqualate; in spinal cord quinolinate appears to be 5-fold less active. The excitations evoked by quinolinate and NMDA are blocked in parallel by 2-amino-5-phosphonovalerate, suggesting that they react with a common receptor.
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D007478:Iontophoresis; D008845:Microinjections; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects; D010069:Oxadiazoles / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D016318:Quisqualic Acid; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*; D013268:Stimulation, Chemical; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D010069:Oxadiazoles; D011725:Pyridines; D011805:Quinolinic Acids; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D016318:Quisqualic Acid; D017378:Quinolinic Acid; D014633:Valine