An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus.
The adenosine agonist 2-chloroadenosine inhibited the K+-induced release of endogenously synthesized [3H]glutamate but not [3H]GABA from slices of rat dentate gyrus. In contrast, the K+-stimulated release of [3H]glutamate was augmented by the adenosine antagonist theophylline and was further enhanced by the cyclic AMP analogue 8-bromo-cyclic AMP in the presence of theophylline.
D015762:2-Chloroadenosine; D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology*; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D015762:2-Chloroadenosine; D015124:8-Bromo Cyclic Adenosine Monophosphate; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D013806:Theophylline; D000241:Adenosine; D011188:Potassium