Hemidesmosomes of normal and regenerating mouse corneal epithelium.
Hemidesmosomes of normal mouse corneal epithelium observed in tangential thin sections, occupy 14% of the basal plasma membrane. They consist of linear chains of densities with an orientation that is not random with respect to the radial axis of the cornea, tending to parallel it. During the repair of a small epithelial defect, cells of the corneal epithelium peripheral to the defect show chains of hemidesmosomes arranged parallel to the direction of migration of the epithelial sheet. This is parallel to the radius, like the orientation of the normal chains. Cells of the area that was denuded of epithelium, and is being resurfaced, show no hemidesmosomes. During repair of a large defect of the corneal epithelium hemidesmosomes are present on the cells covering the denuded area but they are small, few in number compared to the normal, and many are not arranged in chains. These small hemidesmosomes appear to be points of attachment of very fine basal filaments, possibly actin.
D000818:Animals; D003315:Cornea / Q000502:physiology / Q000648:ultrastructure*; D003316:Corneal Diseases / Q000473:pathology; D003896:Desmosomes / Q000648:ultrastructure*; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D008297:Male; D051379:Mice; D012038:Regeneration