[The central nervous system, regulation of blood pressure and hypertension. Recent advances in the role of the central nervous system in the regulation of blood pressure].
Evidence for a contribution of the central nervous system to the development and maintenance of high blood pressure disease is accumulating. Increased activity of the sympathetic nervous system has been demonstrated experimentally and clinically. Centrally acting drugs such as a-methyldopa, clonidine or reserpine effectively lower blood pressure. CNS dysregulation, as seen by alterations in neurotransmitter concentrations or baroreceptor reflex function, have been detected in early stages of hypertension. In animal experiments renal hypertension could be prevented by central chemical sympathectomy. Finally, psychosocial stress can induce sustained hypertension and a relationship between personality pattern, conflict behaviour and high blood pressure has been established.
D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000503:physiopathology*; D001927:Brain Diseases / Q000150:complications; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000502:physiology; D051381:Rats
D018377:Neurotransmitter Agents
Zentralnervensystem, Blutdruckregulation und Hypertonie. Neuere Erkenntnisse zur zentralnervösen Steuerung des Blutdrucks.