Complexation of tetracyclines with metal ions in relation to photosensitization.
It has been shown by spectroscopy and by a Photosensitive Index method, involving measurements of interfacial tension, that Cu2+ and Ni2+ form 2:1 complexes with oxytetracycline and 1:1 complexes with demethylchlortetracycline. Fe2+, Zn2+, Mg2+ and Ca2+ form weaker 1:1 complexes with both drugs. The possibility is discussed of using metal ions to reduce photosensitization by tetracyclines in-vivo.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003707:Demeclocycline / Q000032:analysis; D006801:Humans; D008670:Metals / Q000032:analysis*; D010118:Oxytetracycline / Q000032:analysis; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D013056:Spectrophotometry, Ultraviolet; D013754:Tetracyclines / Q000009:adverse effects / Q000032:analysis*
D008670:Metals; D013754:Tetracyclines; D003707:Demeclocycline; D010118:Oxytetracycline