Fate of orally given isosorbide dinitrate in man: factors of variability.
After oral administration of isosorbide dinitrate, plasma concentrations of isosorbide dinitrate and mononitrates can be measured. An attempt was made to identify a number of factors which influence these plasma concentrations. Presence of renal failure, acute or chronic treatment with beta-blocking agents, and chronic cimetidine treatment did not influence the plasma concentrations. In a number of patients with cirrhosis, however, plasma concentrations of isosorbide dinitrate were found to be higher than in noncirrhotic patients.
D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008297:Male
D000319:Adrenergic beta-Antagonists; D002927:Cimetidine; D007548:Isosorbide Dinitrate