More confined indications for use of combined passive and active immunization for preventing perinatal development of hepatitis B virus carrier-state--based on the natural history of hepatitis B virus-vertical transmission.
To find more confined criteria for use of passive and/or active immunization for preventing perinatal development of hepatitis B virus (HBV) carrier-state than maternal HBe antigenemia, maternal HBsAg-titers (R-PHA) around delivery and infantile HBeAg-titers-(EIA) are discussed. No children whose maternal HBsAg-titers around delivery were lower than 3(6) developed carrier-state in spite of maternal HBe antigenemia. In addition, at age 2 months serum HBeAg-titers of 6 children who had acquired persistent HBsAb were lower than 25, while those of 5 children who had developed carrier-state were higher than 70. These findings may contribute to the establishment of more confined indications for the administration of HBIG and/or HB vaccine to the children born to HBeAg-positive carrier women, saving not only HBIG and HB vaccine but all accompanied efforts of both patients and medical staff as well.
D002353:Carrier State / Q000276:immunology*; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control* / Q000635:transmission; D006511:Hepatitis B Antigens / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis* / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007231:Infant, Newborn; D011247:Pregnancy
D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens