title: Mathematical model for hormonal therapy (vasopressin, corticoids) in cerebral collapse and malignant tumors of the brain (36 cases).
abstract: A mathematical model of the adrenal postpituitary system has been used in cases of brain disease in which endocrine disturbances play an aggravating role. A computer simulation has suggested a type of therapy adding vasopressin to corticoids; this association seems to elicit better results than corticoids alone. Posttraumatic disorders of the cerebral hydration, on one hand, and inoperable or recurrent tumors, on the other hand, take advantage of such a systemic, formalized approach.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000368:Aged; D001127:Arginine Vasopressin; D001254:Astrocytoma / Q000188:drug therapy*; D001927:Brain Diseases / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary; D003201:Computers; D003681:Dehydration / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives; D008962:Models, Theoretical; D009364:Neoplasm Recurrence, Local; D013788:Thalamus; D014667:Vasopressins / Q000008:administration & dosage*
chemical_list: D000305:Adrenal Cortex Hormones; C016671:pitressin tannate; D014667:Vasopressins; D001127:Arginine Vasopressin; C021650:hydrocortisone acetate; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; C018038:dexamethasone acetate; D006854:Hydrocortisone