Increased leucocyte oxidative metabolism in hyperlipoproteinaemia.
Polymorphonuclear leucocytes (PMN) from a group of subjects with hyperlipoproteinaemia (HLP) had higher oxidative metabolism with greater release of superoxide anion (O2-) than PMN from age-matched controls. Release of O2- was significantly correlated with serum cholesterol and light-density-lipoprotein-cholesterol levels, PMN from HLP subjects also has higher hexose monophosphate shunt activity and chemiluminescence than controls. A causal relation was suggested by the finding that oxidative metabolism was normal in a group of HLP subjects whose lipid levels were lowered by treatment with cholestyramine.
D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology; D002792:Cholestyramine Resin / Q000627:therapeutic use; D005609:Free Radicals; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood* / Q000188:drug therapy; D008074:Lipoproteins / Q000097:blood; D009249:NADP / Q000096:biosynthesis; D009504:Neutrophils / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000097:blood*; D012306:Risk; D013481:Superoxides / Q000097:blood*
D005609:Free Radicals; D008074:Lipoproteins; D002792:Cholestyramine Resin; D013481:Superoxides; D009249:NADP; D010100:Oxygen