[Action of etmozin and ethacizin on dopaminergic adenylate cyclase of the striate system of the brain].
The authors studied the effect of phenothiazine and butyrophenone neuroleptics and that of the antiarrhythmic drugs etmozine and etacizine on the dopamine--activated adenylate cyclase of the rabbit brain striatum. It was shown that all the neuroleptics under study prevented the development of the activating effect of dopamine, whereas the antiarrhythmic drugs administered at the same concentrations did not influence adenylate cyclase stimulation with dopamine. The affinity of etmozine and etacizine for dopamine receptors was 15-20 times less than the affinity of the typical neuroleptic trifluoroperazine. It is concluded that application of etmozine and etacizine to the treatment of arrhythmias is not complicated by neuroleptic or other dopaminergic effects of these drugs.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology; D002090:Butyrophenones; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology; D004298:Dopamine / Q000378:metabolism; D066298:In Vitro Techniques; D016293:Moricizine / Q000031:analogs & derivatives; D010640:Phenothiazines / Q000494:pharmacology*; D011817:Rabbits; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D014150:Antipsychotic Agents; D002090:Butyrophenones; D010640:Phenothiazines; D011954:Receptors, Dopamine; C027240:diethylamino-ethmozine; D016293:Moricizine; D000262:Adenylyl Cyclases; D004298:Dopamine
Deĭstvie étmozina i étatsizina na dofaminergicheskuiu adenilattsiklazu straitnoĭ sistemy mozga.