title: Acidic amino acid antagonists of lateral perforant path synaptic transmission: agonist-antagonist interactions in the dentate gyrus.
abstract: Acidic amino acid antagonists were tested for their ability to block depolarizations produced by excitatory amino acids in the outer molecular layer of the dentate gyrus in hippocampal slices. 2-Amino-4-phosphonobutyrate (APB) and serine-O-phosphate (SOP), potent synaptic blockers of the lateral perforant path input to this system, are moderately selective antagonists of kainate and N-methyl-DL-aspartate depolarizations, but not depolarizations produced by L-glutamate, quisqualate, or serine-O-sulfate. N-Methyl-DL-aspartate responses were potently blocked by 2-amino-5-phosphonovalerate, but this antagonist is less potent than APB or SOP against the synaptic response.
mesh_terms: D015763:2-Amino-5-phosphonovalerate; D000596:Amino Acids / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D004553:Electric Conductivity; D006624:Hippocampus / Q000187:drug effects*; D007478:Iontophoresis; D008297:Male; D010768:Phosphoserine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D000613:Aminobutyrates; D010768:Phosphoserine; D015763:2-Amino-5-phosphonovalerate; C012729:2-amino-4-phosphonobutyric acid; D014633:Valine