title: Histamine stimulates renin release from the isolated perfused rat kidney.
abstract: The renal effects of histamine, histamine receptor agonists and antagonists were studied in the isolated rat kidney, which was perfused with a synthetic medium at constant perfusion pressure in a single pass system. Histamine induced a concentration-dependent increase of renin release ranging from a two-fold increase at 0.5 microM to a four-fold increase at 10 microM. No change in renal vascular resistance, glomerular filtration rate and sodium excretion occurred. Histamine-H2-antagonists (ranitidine and cimetidine) were more effective to block the response to histamine than was the histamine H1-antagonist diphenhydramine. Histamine-H2-agonists (impromidine and dimaprit, 2.5 microM each) were potent stimulators of renin release, their effect was blunted by H2-antagonists. The histamine-H1-agonist pyridyl-2-ethylamine had a low stimulatory activity at 10 microM final concentration, which may reflect partial H2-agonistic effects. It is concluded that histamine stimulates renin release via H2-receptor activation.
mesh_terms: D000818:Animals; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects; D012083:Renin / Q000378:metabolism*
chemical_list: D006634:Histamine H1 Antagonists; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D006632:Histamine; D012083:Renin