title: Short-term regulation of hydroxylase cofactor activity in rat brain.
abstract: Differential drug effects on hydroxylase cofactor activities were observed in the corpus striatum and the locus coeruleus when conditions of sacrifice were controlled. A conformational stability-dependent variable degree of stoichiometric coupling between quinonoid dihydropteridine reductase and tyrosine hydroxylase is proposed as a short-latency influence on hydroxylase cofactor levels.
mesh_terms: D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives / Q000502:physiology*; D002940:Circadian Rhythm; D003342:Corpus Striatum / Q000201:enzymology*; D003913:Dextroamphetamine / Q000494:pharmacology; D007700:Kinetics; D008125:Locus Coeruleus / Q000201:enzymology*; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D010830:Physostigmine / Q000494:pharmacology; D011621:Pteridines / Q000502:physiology*; D011622:Pterins / Q000378:metabolism; D011809:Quinones / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
chemical_list: D011621:Pteridines; D011622:Pterins; D011809:Quinones; D001708:Biopterins; D012110:Reserpine; D010830:Physostigmine; D010088:Oxidoreductases; C022513:quinonoid dihydropterin reductase; D014446:Tyrosine 3-Monooxygenase; C003402:sapropterin; D003913:Dextroamphetamine