title: A central role for the polyamines in the aetiology of schizophrenia.
abstract: The general consensus of opinion in psychopharmacology is that the basic lesion in schizophrenia is a defect of the dopaminergic mechanism in some part or parts of the brain. In this article I wish to show that there is sufficient evidence to indicate that the central lesion involves the polyamines rather than dopamine.
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology*; D006213:Hallucinogens / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D011073:Polyamines / Q000502:physiology*; D011433:Propranolol; D012559:Schizophrenia / Q000209:etiology* / Q000503:physiopathology; D013095:Spermidine / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D014150:Antipsychotic Agents; D006213:Hallucinogens; D011073:Polyamines; D011433:Propranolol; D013095:Spermidine