title: Cimetidine-drug interactions.
abstract: The use of cimetidine, the histamine H2 receptor antagonist, is associated with a relatively low incidence of adverse reactions. However, its liberal use has led to the identification of several clinically significant cimetidine-drug interactions that can lead to drug accumulation, toxicity, and life-threatening sequelae. A review of the literature and the clinical significance and physiologic basis of these interactions are presented. Recommended management of cimetidine-drug interactions is discussed.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000378:metabolism; D000927:Anticonvulsants / Q000378:metabolism; D001569:Benzodiazepines / Q000378:metabolism; D002719:Chlormethiazole / Q000378:metabolism; D002927:Cimetidine / Q000009:adverse effects* / Q000494:pharmacology; D004347:Drug Interactions; D006801:Humans; D007654:Ketoconazole / Q000378:metabolism; D007668:Kidney / Q000187:drug effects; D008012:Lidocaine / Q000378:metabolism; D009020:Morphine / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism; D013806:Theophylline / Q000378:metabolism
chemical_list: D000319:Adrenergic beta-Antagonists; D000927:Anticonvulsants; D010406:Penicillins; D002719:Chlormethiazole; D001569:Benzodiazepines; D009020:Morphine; D002927:Cimetidine; D008012:Lidocaine; D013806:Theophylline; D007654:Ketoconazole