title: Bordetella pertussis-induced impairment of relaxation of rat trachea to isoprenaline and histamine and its reversal with hydrocortisone.
abstract: Bordetella pertussis vaccination of rats resulted in impairment of relaxation to isoprenaline and histamine of partially contracted tracheal smooth muscle. The concentration range of carbachol (10(-6) to 5 x 10(-6) M) required for contraction (ED50) did not differ from the control group. Pretreatment of vaccinated animals with hydrocortisone was found to reverse the inhibition of spasmolytic activity.
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006635:Histamine H2 Antagonists; D006854:Hydrocortisone / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D010567:Pertussis Vaccine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014132:Trachea / Q000187:drug effects*
chemical_list: D006635:Histamine H2 Antagonists; D010567:Pertussis Vaccine; D006632:Histamine; D002217:Carbachol; D007545:Isoproterenol; D006854:Hydrocortisone