Identification of the altered ribosomal component responsible for resistance to micrococcin in mutants of Bacillus megaterium.
A mutant strain of Bacillus megaterium, arising spontaneously and resistant to micrococcin , possesses ribosomes which contain an altered form of protein BM-L11 (the homologue of Escherichia coli protein L11). Reconstitution analysis has revealed that the alteration to protein BM-L11 is the sole cause of resistance in this strain.
D000900:Anti-Bacterial Agents; D001410:Bacillus megaterium / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000302:isolation & purification* / Q000502:physiology; D001430:Bacteriocins; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D020558:GTP Phosphohydrolases / Q000302:isolation & purification; D009154:Mutation; D010455:Peptides / Q000494:pharmacology; D012335:RNA, Ribosomal / Q000302:isolation & purification; D012269:Ribosomal Proteins / Q000302:isolation & purification* / Q000494:pharmacology; D012270:Ribosomes / Q000201:enzymology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001430:Bacteriocins; D010455:Peptides; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins; C027624:ribosomal protein L11; C009779:micrococcin; D020558:GTP Phosphohydrolases