Opioid peptides and seizures in the spontaneously epileptic Mongolian gerbil.
The naturally epileptic Mongolian gerbil was used to investigate the epileptogenic properties of beta-endorphin, dynorphin, met-enkephalin and morphine. The results indicate that opioid induced "seizures" are different from naturally spontaneous seizures in the gerbil in respect to EEG recording and motor behavior. Evidence for a protective role in preventing seizures is also presented.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004399:Dynorphins; D004723:Endorphins / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000494:pharmacology; D004827:Epilepsy / Q000503:physiopathology*; D005849:Gerbillinae; D009020:Morphine / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology; D012640:Seizures / Q000503:physiopathology*; D001615:beta-Endorphin
D004723:Endorphins; D009294:Narcotics; D004744:Enkephalin, Methionine; D009271:Naltrexone; D001615:beta-Endorphin; D004399:Dynorphins; D009020:Morphine