[Use of different precursors of fatty acid biosynthesis in the brain in chronic hyperphenylalaninemia].
The incorporation of 14C from 2-14C-acetate, 1-6-14C-glucose and 5-14-C-glutamate into fatty acids of brain lipids under chronic hyperphenylalaninemia (HPA) was investigated. A decrease of lipogenesis intensity was demonstrated in young rat brain. In the HPA a decrease in the labelling of fatty acids occurred due to inhibition of the enzymes of fatty acid biosynthesis and to disturbance of metabolic pathways involved in lipogenesis via acentyl-CoA.
D000085:Acetates / Q000378:metabolism; D000105:Acetyl Coenzyme A / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002250:Carbon Radioisotopes / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis* / Q000097:blood; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D010649:Phenylalanine / Q000097:blood*; D051381:Rats
D000085:Acetates; D002250:Carbon Radioisotopes; D005227:Fatty Acids; D005971:Glutamates; D018698:Glutamic Acid; D010649:Phenylalanine; D000105:Acetyl Coenzyme A; D007521:Isocitrate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005947:Glucose
Ispol'zovanie razlichnykh predshestvennikov dlia biosinteza zhirnykh kislot v golovnom mozge v usloviiakh khronicheskoĭ giperfenilalaninemii.