title: Uptake of D-[3H]aspartic acid by hippocampal slices: the influence of low and high frequency activation of nerve endings.
abstract: Schaffer collaterals (Sch. coll.) projection and perforant path (PP) fibers in the hippocampal slices were stimulated in the presence of 0.8 microM D-[3H]aspartic acid--a marker of glutamergic nerve terminals. The activation of these fibers evoked a frequency and sodium-dependent increase of D-[3H]aspartate uptake. The increase of D-aspartate uptake during Schaffer collaterals stimulation was much higher than during perforant path stimulation. The stimulation of Sch. coll. nerve endings, which was preceded by a high frequency stimulation of these fibers (potentiation), evoked a decrease of D-aspartate uptake as compared to stimulated controls.
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D046508:Culture Techniques; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006624:Hippocampus / Q000502:physiology*; D008564:Membrane Potentials; D009411:Nerve Endings / Q000502:physiology*; D051381:Rats; D009435:Synaptic Transmission
chemical_list: D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid