title: Influence of cisternal pressure on passage of neuropeptides from the cerebrospinal fluid into the peripheral circulation.
abstract: Passage of neuropeptides from the cerebrospinal fluid to circulation depends upon cisternal pressure. When cisternal collecting pressure was kept at -20 cm, plasma levels of gastrin-17 and somatostatin-14 remained at basal values despite perfusion of high doses of the peptides into the cerebro-ventricular system. Progressive reduction of this pressure above -15 cm results in a progressive rise of the peripheral concentration of the peptides. Discrimination between central and peripheral action of centrally administered neuropeptides is, therefore, possible.
mesh_terms: D000818:Animals; D005755:Gastrins / Q000097:blood / Q000134:cerebrospinal fluid*; D007427:Intracranial Pressure; D011817:Rabbits; D013004:Somatostatin / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D005755:Gastrins; D013004:Somatostatin; C013550:gastrin 17