Effect of chloroquine and some other antimalarials on the immune mechanism in experimental animals.
The effects of chloroquine and some other antimalarials on the immune responses in experimental animals have been examined. Chloroquine and quinine caused significant decrease of serum anti-SRBC haemagglutination titre. Chloroquine lowered the serum IgM level and also reduced plaque-forming cells in the spleen of mice. The delayed-type hypersensitivity responses to SRBC and the passive cutaneous anaphylaxis were also diminished in rats treated with chloroquine. Thus, the immunosuppressant activity of chloroquine may explain its efficacy in various types of immune disorders.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000962:Antimalarials / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D000962:Antimalarials; D002738:Chloroquine; D001205:Ascorbic Acid