Antigenic association between kidney and thymocyte.
Commonly shared antigens between the renal tissue and lymphocytes, especially the thymocyte were studied in rats by immunofluorescent technique. To clarify the specificity of antisera, absorption analysis was carried out. The brain-associated thymocyte antigen, presumably Thy 1 antigen, was detected by anti-rat thymocyte serum (ATS) or anti-rat brain serum (ABS) not only on the surface of thymocytes but also in renal glomeruli. The distribution or localization of the antigen in glomeruli was considerably different between acetone-fixed and unfixed kidney sections. On the fixed section the antigen was shown exclusively in the glomerular mesangium. However, it appeared to be diffusely dispersed on glomerular tissue on the unfixed section. On the other hand, antisera against kidney-related antigens, anti-Fx1A, anti-GBM, and anti-CIG, did not react with the surface of thymocytes, or they were not absorbed with brain homogenate.
D000096:Acetone / Q000494:pharmacology; D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D001921:Brain / Q000276:immunology; D003429:Cross Reactions; D005260:Female; D005455:Fluorescent Antibody Technique; D007106:Immune Sera; D007668:Kidney / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D051381:Rats; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D007106:Immune Sera; D018800:Thy-1 Antigens; D000096:Acetone