title: Coordinate synthesis of the enzymes of pyrimidine biosynthesis in Bacillus subtilis.
abstract: Strains of Bacillus subtilis that were resistant to repression of pyrimidine nucleotide biosynthetic enzymes were selected by isolating spontaneous uracil-tolerant derivatives of a uracil-sensitive strain, which lacks arginine-repressible carbamyl phosphate synthetase. The relative content of all six enzymes of uridylic acid biosynthesis de novo in these strains was in a constant ratio over a 10-fold range of derepression, which indicates that synthesis of these enzymes is coordinately regulated.
mesh_terms: D001221:Aspartate Carbamoyltransferase / Q000096:biosynthesis; D001412:Bacillus subtilis / Q000201:enzymology*; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000096:biosynthesis; D004080:Dihydroorotase / Q000096:biosynthesis; D004081:Dihydroorotate Oxidase / Q000096:biosynthesis; D009962:Orotate Phosphoribosyltransferase / Q000096:biosynthesis; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000096:biosynthesis; D011743:Pyrimidines / Q000096:biosynthesis*
chemical_list: D011743:Pyrimidines; D004081:Dihydroorotate Oxidase; D001221:Aspartate Carbamoyltransferase; D009962:Orotate Phosphoribosyltransferase; D004080:Dihydroorotase; D009964:Orotidine-5'-Phosphate Decarboxylase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)