Membrane-associated nucleotide pyrophosphatase activity on leucocytes from different compartments.
The distribution of membrane-associated nucleotide pyrophosphatase activity has been investigated on mouse leucocytes of different origin. It is shown that enzyme-specific activity is higher on bone-marrow cells than on cells derived from peripheral organs. Since thymus lymphocytes show the lowest activity, it is obvious that the thymus environment can influence the enzyme activity on bone-marrow stem cells which have entered this organ. Spleen cells from thymus-deficient nude mice displayed more enzyme activity than spleen cells from normal mice, although the percentage of lymphocytes was similar in both donor-cell populations.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000201:enzymology; D001853:Bone Marrow / Q000201:enzymology; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002462:Cell Membrane / Q000201:enzymology; D002470:Cell Survival; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007962:Leukocytes / Q000145:classification / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011480:Protease Inhibitors / Q000494:pharmacology; D011755:Pyrophosphatases / Q000378:metabolism*; D013154:Spleen / Q000166:cytology / Q000201:enzymology; D013601:T-Lymphocytes / Q000201:enzymology
D011480:Protease Inhibitors; D011755:Pyrophosphatases; C021899:nucleotide pyrophosphatase