title: Effect of gamma radiation on enzymatic activity and sulphydryl groups of human erythrocyte membrane.
abstract: The effect of ionizing radiation on human erythrocyte ghost membranes was studied by following changes in membrane -SH groups and activities of four membrane bound enzymes: Na+K+Mg2+ ATP-ase, Mg2+Ca2+ ATP-ase, Na+K+ATP-ase, and AChE. Irradiation up to 100 Gy gamma X-rays produced a significant decrease in the activity of ATP-ase and an increase in AChE activity. At higher radiation doses a marked decrease in the activities of all the enzymes was observed. A correlation between radiation-induced perturbations in enzyme activities and changes in membrane -SH groups was found.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism*
chemical_list: D003037:Cobalt Radioisotopes; D013438:Sulfhydryl Compounds; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; C030704:magnesium sodium potassium ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase