Studies on sound-induced epilepsy in mice.
The cerebral concentrations of pyridoxal-5'-phosphate and divalent transition metal ions (Cu2+ and Zn2+) are appreciably higher in the seizure-susceptible strain of mouse (DBA/2J) than those in normal strains (CBA/Ca and Parkes ). By injecting metal ions intracranially and pyridoxal-5'-phosphate intraperitoneally, we could render the normal mouse prone to sound-induced epilepsy. The behaviour of the treated seizure-susceptible strain of mouse. The levels of glutamate and aspartate in its inferior colliculus were elevated and the concentration of gamma-aminobutyrate was lowered. Glutaminase inhibitors, 6-diazo-5-oxo-L-norleucine (DON) and 0-diazo-acetyl-L-serine (azaserine), and a transaminase inhibitor, 4-amino-3- isoxazolidone (L-cycloserine), when injected intraperitoneally, protected the seizure-susceptible mouse from undergoing convulsions, whereas pyridoxal-5'-phosphate and methionine sulphoximine, a glutamine synthetase inhibitor, exacerbated its epileptic condition. We propose a possible sequence of biochemical events associated with susceptibility to audiogenic seizures.
D000161:Acoustic Stimulation; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D004827:Epilepsy / Q000209:etiology* / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008954:Models, Biological; D011732:Pyridoxal Phosphate / Q000378:metabolism; D000637:Transaminases / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D000596:Amino Acids; D011732:Pyridoxal Phosphate; D003300:Copper; D000637:Transaminases; D015032:Zinc