The effects of prolyl-leucyl-glycine amide on drug-induced rotation in lesioned rats.
1. The effects of L-prolyl-L-leucyl-glycine amide (PLG) on drug-induced rotational behavior were studied in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra. 2. Although PLG alone was found to be ineffective at inducing rotation in these animals, pretreatment with PLG at various doses was found to enhance both amphetamine and apomorphine-induced rotation. 3. This response proved to be biphasic with loss of activity in the higher dose ranges. 4. The pattern of effects observed suggests that PLG may act postsynaptically at a non-striatal site.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006892:Hydroxydopamines / Q000494:pharmacology; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013238:Stereotaxic Techniques; D013378:Substantia Nigra / Q000187:drug effects
D006892:Hydroxydopamines; D016627:Oxidopamine; D009075:MSH Release-Inhibiting Hormone; D000661:Amphetamine; D001058:Apomorphine