title: Oral acute toxicity with stimulants and blockers of beta-adrenoceptors in singly-housed or aggregated mice.
abstract: Acute oral toxicity of the three Beta-adrenoceptor stimulants Orciprenalin, Fenoterol and Salbutamol as well as the two Beta-adrenoceptor blockers Pindolol and Bunitrolol was studied in singly-housed and aggregated male and female mice (ICR-JCL) and the results were compared with those in grouped mice (background studies). With a few exceptions, the acute toxic potency of the five test substances in mice appeared to be: Aggregated mice greater than grouped mice greater than singly-housed mice.
mesh_terms: D000284:Administration, Oral; D000318:Adrenergic beta-Agonists / Q000633:toxicity*; D000319:Adrenergic beta-Antagonists / Q000633:toxicity*; D000374:Aggression / Q000187:drug effects; D000818:Animals; D005260:Female; D006799:Housing, Animal; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists