title: The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo.
abstract: The quinolines PK 8165 and PK 9084 bind to brain benzodiazepine receptors in vitro. However, unlike diazepam, these molecules do not reduce GABA turnover, possess anxiolytic properties, or displace [3H]flunitrazepam from benzodiazepine receptors in vivo. The pharmacological properties of PK 8165 and PK 9084 in vivo are thus unrelated to the benzodiazepine receptor.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology; D005445:Flunitrazepam / Q000378:metabolism; D066298:In Vitro Techniques; D051379:Mice; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
chemical_list: D014151:Anti-Anxiety Agents; D011804:Quinolines; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid; D005445:Flunitrazepam; C030079:PK 9084; C030078:pipequaline; D003975:Diazepam