Effect of histamine-receptor blocking on human spontaneous lymphocyte-mediated cytotoxicity.
The effect of H1- and h2-receptor-blocking agents on spontaneous lymphocyte-mediated cytotoxicity (SLMC) was studied. The H1-receptor blocker clemastinum and the H2-receptor blocker cimetidine inhibited the spontaneous cytotoxic activity of normal human peripheral blood lymphocytes on K-562 target cells dose-dependently. The inhibition cannot be explained either by a direct toxic effect on natural killer (NK) cells or by blocking of Fc receptors. The possible involvement of histamine receptor-bearing lymphocytes in human SLMC is suggested.
D002927:Cimetidine / Q000494:pharmacology; D002974:Clemastine / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D011968:Receptors, Histamine / Q000276:immunology*; D011969:Receptors, Histamine H1 / Q000276:immunology*; D011970:Receptors, Histamine H2 / Q000276:immunology*
D006634:Histamine H1 Antagonists; D007141:Immunoglobulin Fc Fragments; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D002927:Cimetidine; D002974:Clemastine