Effects of retinal and pineal low molecular weight fractions and antipsychotic drugs on hydroxyindole-O-methyltransferase.
Fractions from bovine retinas and sheep pineals of low molecular weight decrease the activity of purified hydroxyindole-O-methyltransferase (HIOMT). The antipsychotic drugs chlorpromazine and haloperidol show a similar effect under the same experimental conditions. It is suggested that they may imitate the effect of (an) unknown natural suppressor(s) of HIOMT-activity, present in retina and pineal, decreasing the biosynthesis of methoxyindoles.
D000121:Acetylserotonin O-Methyltransferase / Q000037:antagonists & inhibitors*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002417:Cattle; D002746:Chlorpromazine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D008970:Molecular Weight; D010870:Pineal Gland; D012160:Retina; D012756:Sheep; D014020:Tissue Extracts / Q000494:pharmacology*
D014150:Antipsychotic Agents; D014020:Tissue Extracts; D008780:Methyltransferases; D000121:Acetylserotonin O-Methyltransferase; D006220:Haloperidol; D002746:Chlorpromazine