Effect of dieldrin on rat liver plasma membrane enzymes.
Dieldrin, an organochlorine insecticide, when administered orally to male albino rats at a dose of 5 mg/kg body weight/day for 15 days inhibits the enzyme Mg2+ -ATPase and stimulates the activity of 5'-nucleotidase and NADH-dehydrogenase in liver plasma membrane. L-ascorbic acid supplementation offers some protection in relation to the inhibition of Mg2+ -ATPase.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D017301:Ca(2+) Mg(2+)-ATPase; D002462:Cell Membrane / Q000201:enzymology; D004026:Dieldrin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009245:NADH Dehydrogenase / Q000378:metabolism; D009708:Nucleotidases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D009245:NADH Dehydrogenase; D009708:Nucleotidases; C030287:nucleotidase; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D004026:Dieldrin; D001205:Ascorbic Acid