Influence of dopamine receptor agonists on gastric acid secretion induced by intraventricular administration of thyrotropin-releasing hormone in the perfused stomach of anaesthetized rats.
1 The influence of dopamine receptor agonists on gastric acid secretion stimulated by thyrotropin-releasing hormone (TRH) was studied in the perfused stomach of anaesthetized rats. 2 Intraventricular TRH produced a dose-dependent stimulation of basal gastric acid secretion. 3 Pretreatment with apomorphine, bromocriptine or methamphetamine inhibited the TRH-stimulated gastric acid secretion; these drugs did not influence bethanechol-induced acid secretion. 4 Haloperidol and metoclopramide prevented the antisecretory effects of apomorphine, bromocriptine and methamphetamine. 5 The present study suggests that central dopamine receptor stimulation inhibits intraventricular TRH-induced gastric acid secretion in rats.
D000758:Anesthesia; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology; D004347:Drug Interactions; D005744:Gastric Acid / Q000378:metabolism*; D007276:Injections, Intraventricular; D007441:Intubation, Gastrointestinal; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D001626:Bethanechol Compounds; D011954:Receptors, Dopamine; D018723:Bethanechol; D001971:Bromocriptine; D008694:Methamphetamine; D013973:Thyrotropin-Releasing Hormone; D001058:Apomorphine