Benzodiazepine receptor number after acute administration of alprazolam and diazepam.
Acute administration of alprazolam and diazepam (50 mg/kg i.p.) significantly increased benzodiazepine receptors in distilled water-washed rat brain membrane preparation. Similar effects were not observed when rat brain membranes were washed with phosphate-buffered saline. Results are discussed with respect to solubilization of benzodiazepine receptors in distilled water.
D000525:Alprazolam; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D005445:Flunitrazepam / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008566:Membranes / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000187:drug effects*; D011963:Receptors, GABA-A
D014151:Anti-Anxiety Agents; D011955:Receptors, Drug; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005445:Flunitrazepam; D003975:Diazepam; D000525:Alprazolam