The mechanism of the histamine-induced desensitization of guinea-pig ileum.
Histamine and the selective H1 receptor agonist 2-pyridylethylamine show cross-desensitization when tested in guinea-pig ileum. The H1 receptor blocking agent produces a smaller parallel shift in desensitized tissues when compared with non-desensitized controls. We conclude that desensitization in this system occurs at the receptor level and is reflected by a decreased sensitivity to both agonists and antagonists.
D000818:Animals; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects*
D006634:Histamine H1 Antagonists; D008761:Methylhistamines; D011725:Pyridines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D006632:Histamine; C006183:2-(2-aminoethyl)pyridine; C026259:2-methylhistamine; D011738:Pyrilamine