title: Hydrocarbon metabolism and cortisol balance in oil-exposed ringed seals, Phoca hispida.
abstract: 1. Ringed seals were exposed experimentally to oil contamination, by feeding of a [14C]naphthalene marked crude oil in fish for up to 4 days at a rate of 5 ml/day. 2. Mixed function oxygenase (MFO) activity, measured as aryl hydrocarbon hydroxylase in liver and kidney, was found to be induced, in particular in kidney tissue where the activity increased 3-fold. 3. MFO induction correlated with a high degree of conversion of crude oil hydrocarbons to water-soluble metabolites. Most of the radioactivity was found in the polar fraction of plasma and urine. 4. Plasma cortisol levels were somewhat elevated by captive holding, and increased markedly after oil-exposure. Cortisol half-life decreased after oil exposure from 1 3/4 to 1 hr.
mesh_terms: D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D010872:Caniformia / Q000378:metabolism*; D004032:Diet; D005648:Fuel Oils / Q000633:toxicity*; D006854:Hydrocortisone / Q000097:blood*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010578:Petroleum / Q000633:toxicity*; D046048:Seals, Earless / Q000378:metabolism*
chemical_list: D005648:Fuel Oils; D010578:Petroleum; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D001189:Aryl Hydrocarbon Hydroxylases; D006854:Hydrocortisone