title: Alfentanil in minor gynaecological surgery: use with etomidate and a comparison with halothane.
abstract: Etomidate was used to induce anaesthesia in 50 healthy subjects undergoing minor gynaecological surgery who were randomly divided into two groups, one receiving alfentanil 8 micrograms/kg intravenously immediately prior to induction of anaesthesia with etomidate, and the other halothane as required to maintain adequate anaesthesia. There was a highly significant reduction in the incidence of myoclonia and involuntary movement and significant reduction of pain on injection in the alfentanil group. Tests of recovery performed in the 60 minutes following anaesthesia suggested that supplementation with alfentanil led to more rapid recovery than halothane.
mesh_terms: D000759:Adjuvants, Anesthesia; D000293:Adolescent; D000328:Adult; D015760:Alfentanil; D000556:Ambulatory Surgical Procedures; D000701:Analgesics, Opioid; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D005045:Etomidate / Q000009:adverse effects; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives*; D006221:Halothane; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D011897:Random Allocation; D013997:Time Factors
chemical_list: D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D007093:Imidazoles; D015760:Alfentanil; D005283:Fentanyl; D006221:Halothane; D005045:Etomidate