Role of alpha and beta adrenoceptors on the salivary secretion in the mandibular gland of the rabbit.
The stimulation of the superior cervical ganglion increased the salivary flow rate (about five-fold) in all 35 rabbits studied but two. The administration of alpha or beta adrenoceptor blocking drugs was unable to eliminate the positive effect of the sympathetic stimulation on the salivary flow, though the flow rate fell about 50% with the administration of each of the blockers. According to these results both types of receptors may be involved in the secretory response of this gland. Nevertheless it seems that the beta-adrenoceptors play a more important role in the secretory response and the alpha-adrenoceptors in the motor one.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D011817:Rabbits; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012472:Salivation / Q000187:drug effects; D013363:Submandibular Gland / Q000098:blood supply / Q000294:innervation / Q000378:metabolism*; D014661:Vasoconstriction
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta