Iron overload in mild sideroblastic anaemias.
Life-threatening iron overload may occur without severe anaemia in patients with sideroblastic disorders. Assessment of erythroid expansion in bone-marrow aspirates may be as useful as ferrokinetic studies in predicting both the risk of iron loading and the need for prophylactic phlebotomy or iron-chelation therapy.
D000328:Adult; D000756:Anemia, Sideroblastic / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D001815:Bloodletting; D002614:Chelating Agents / Q000627:therapeutic use; D004032:Diet; D004909:Erythrocyte Indices; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012306:Risk
D002614:Chelating Agents; D006680:HLA Antigens; D007501:Iron