Induction of metallothionein and effect on essential metals in cadmium-loaded frog Xenopus laevis.
1. Cadmium (Cd) was administered orally as metallothionein (MT) in food or intramuscularly as MT and Cd2+ into a frog Xenopus laevis. 2. Oral administration resulted in low accumulation of Cd without affecting essential metal levels. 3. Intramuscular administrations of Cd as MT and Cd2+ resulted in accumulation of Cd in the kidney and in the liver and kidney, respectively, by inducing a Cd-binding protein which has properties characteristic of MT.
D000284:Administration, Oral; D000818:Animals; D002104:Cadmium / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D007273:Injections, Intramuscular; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008667:Metalloproteins / Q000378:metabolism*; D008668:Metallothionein / Q000378:metabolism*; D011817:Rabbits; D014982:Xenopus laevis
D008667:Metalloproteins; D002104:Cadmium; D008668:Metallothionein