First pass conjugation of phenol following rectal administration in rats.
The systemic availability of phenol following rectal administration to rats has been compared to intraduodenal and intravenous administration via the hepatic portal and jugular veins. Phenol blood concentration-time curves after the rectal route of dosing indicate that first pass conjugation by the intestinal mucosa and liver is drastically reduced when compared to the other routes of administration.
D000818:Animals; D001711:Biotransformation; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000378:metabolism; D007441:Intubation, Gastrointestinal; D008099:Liver / Q000378:metabolism; D008297:Male; D019800:Phenol; D010636:Phenols / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013488:Suppositories
D010636:Phenols; D013488:Suppositories; D019800:Phenol