The effects of somatostatin on serum growth hormone levels in the goldfish, Carassius auratus.
In the present study the effects of somatostatin on serum growth hormone (GH) levels in the goldfish, Carassius auratus, were investigated. A single intraperitoneal injection of either 0.1 or 1.0 micrograms somatostatin/g body wt caused a significant decrease in serum GH levels at 1 h postinjection compared to vehicle-injected controls. Two intraperitoneal injections of somatostatin (1.0 micrograms/g body wt), given 12 hr apart, caused a significant decrease in serum GH levels, compared to both presample and vehicle-injected control groups at 1.5 and 6 hr following the second injection. In fish given two injections of somatostatin, a post inhibitory rebound in serum GH levels occurred by 24 hr following the second injection. Thyrotropin-releasing hormone (1 micrograms/g body wt), given as a control peptide, caused a significant increase in serum GH levels at 24 hr, but no significant changes were found at 1.5 or 6 hr following the second of two intraperitoneal injections given 12 hr apart. The increases in serum GH at 24 hr may be due to stress. The results demonstrate that somatostatin causes a transient decrease in blood GH levels in goldfish.
D000818:Animals; D005260:Female; D006054:Goldfish; D013006:Growth Hormone / Q000097:blood*; D007700:Kinetics; D008297:Male; D012741:Sexual Maturation; D013004:Somatostatin / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone