Effect of age on the establishment of muscle paralysis induced in anaesthetized adult subjects by ORG NC 45.
The establishment of muscle paralysis produced by a single dose of 70 micrograms . kg-1 of ORG NC 45 was studied in 30 healthy anaesthetized patients, aged 15-85 years, by recording adductor pollicis isometric mechanical activity-twitch height (TH). Significant correlations were observed between age and the latency of ORG NC 45 action, defined as the reduction of TH to 95% of its initial value (r:0.315, P less than 0.05) and between age and the onset time, defined as the time elapsing between ORG NC 45 administration and maximum TH depression observed (r:0.454, P less than 0.005). Correlation between age and maximum TH depression was not significant. These results show that if the maximum TH depression observed after a standard dose of ORG NC 45 is not altered by the age of the patient, the establishment of the paralysis is delayed by ageing.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000758:Anesthesia; D005283:Fentanyl; D006801:Humans; D008723:Methohexital; D008875:Middle Aged; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000494:pharmacology; D010243:Paralysis / Q000139:chemically induced*; D013997:Time Factors; D014673:Vecuronium Bromide
D014673:Vecuronium Bromide; D008723:Methohexital; D010197:Pancuronium; D005283:Fentanyl