title: Brain and ring gland cyclic AMP and cyclic GMP levels during initiation and termination of pupal diapause in flesh flies.
abstract: Brain and ring gland concentrations of cyclic AMP were much higher shortly after pupariation in long day (non-diapause destined) flesh flies than in short day (destined for pupal diapause) flies. This difference was most striking in the ring gland (6 times higher in long day flies). Cholera toxin elevated brain-ring gland cAMP four-fold, thus accounting for its efficacy in averting diapause. No differences in cyclic GMP levels were detected between long and short day flies at pupariation. At diapause termination cAMP and cGMP concentrations in the brain and ring gland and cAMP in whole body homogenates changed only slightly, but whole body concentrations of cGMP rose markedly.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004175:Diptera / Q000502:physiology*; D008675:Metamorphosis, Biological; D011679:Pupa
chemical_list: D000242:Cyclic AMP; D006152:Cyclic GMP