Regulation of ornithine decarboxylase: studies on the effect of insulin and diaminopropane on transglutaminase activity.
Transglutaminase activity measurements in the liver of insulin- and diaminopropane treated chickens showed that insulin enhances activity in the supernatant, but has no effect on the nuclear fraction. In the absence of exogenous Ca++ ions, both fractions were more active, showing that insulin promotes an increase in the available Ca++ ions. No modification was observed after diaminopropane. It follows that changes in ornithine decarboxylase activity previously observed under these conditions are not dependent on transglutaminase activity.
D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D002645:Chickens; D003959:Diamines / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011503:Transglutaminases
D003959:Diamines; D007328:Insulin; C009475:trimethylenediamine; D000217:Acyltransferases; D011503:Transglutaminases; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase