[Effect of alcoholic patients' serum on the reproductive activity of human embryo fibroblasts].
Alcoholics' blood serum produces a greater stimulation of the growth of human embryonic cells as compared with the serum from healthy individuals. In the course of treatment, the serum stimulating influence on the growth of human embryonic cells tended to diminish, approaching that of control. The authors ascertained a statistically significant positive correlation between the intensity of the embryonic cells growth under the influence of blood serum from alcoholic patients on the one hand and some hematologic parameters of these subjects on the other. Sensitizing therapy with teturam had no substantial effect on either the biological properties of alcoholics' serum or on the reproductive activity of fibroblasts, whereas the administration of neuroleptics was associated with a statistically significant decrease in the proliferation of fibroblasts.
D000437:Alcoholism / Q000097:blood* / Q000628:therapy; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002455:Cell Division; D002478:Cells, Cultured; D004221:Disulfiram / Q000627:therapeutic use; D004622:Embryo, Mammalian; D005347:Fibroblasts; D006133:Growth Substances / Q000097:blood*; D006801:Humans
D014150:Antipsychotic Agents; D006133:Growth Substances; D004221:Disulfiram
Vliianie syvorotki krovi bol'nykh alkogolizmom na reproduktivnuiu aktivnost' fibroblastov émbrionov cheloveka.