title: Stimulation of D2-dopamine receptors in rat neostriatum inhibits the release of acetylcholine and dopamine but does not affect the release of gamma-aminobutyric acid, glutamate or serotonin.
abstract: D1-dopamine receptor stimulation did not affect the K+-induced release of [3H]GABA, [3H]glutamate, [3H]serotonin, [3H]dopamine and [14C]acetylcholine from slices of rat neostriatum. D2-dopamine receptor stimulation did not change the release of [3H]GABA, [3H]glutamate and [3H]serotonin, but inhibited the release of both [3H]dopamine and [14C]acetylcholine; this inhibition was antagonized by (-)-sulpiride. The release-inhibiting dopamine autoreceptors and the post synaptic dopamine receptors mediating the inhibition of acetylcholine release appear to be pharmacologically similar and can be classified as D2-receptors.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008297:Male; D011188:Potassium / Q000494:pharmacology; D011699:Putamen / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005971:Glutamates; D011954:Receptors, Dopamine; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D011188:Potassium; D004298:Dopamine