Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma.
The two-component hypothesis of acute inflammation postulates that the acute inflammatory response depends on both increased local blood flow and increased microvascular permeability: the validity of this concept has previously been established in animals and was tested here in man. A mixture of the mediators prostaglandin E2 and bradykinin produces a larger cutaneous wheal (volume) response than can be accounted for either by summation of the responses to the individual substances or by the slopes of their dose-response curves. This enhanced response is inhibited by noradrenaline (consistent with the vasoconstrictor property of noradrenaline) and by salbutamol (consistent with the anti-permeability property of salbutamol). These observations indicate that the two-component hypothesis of acute inflammation applies to man as well as animals; this finding is important in the evaluation of the role of putative mediators in the pathogenesis of asthma and other diseases in which inflammation plays a part.
D000208:Acute Disease; D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000209:etiology*; D001920:Bradykinin / Q000494:pharmacology / Q000502:physiology*; D002199:Capillary Permeability / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008954:Models, Biological; D011458:Prostaglandins E / Q000494:pharmacology / Q000502:physiology*
D011458:Prostaglandins E; D001920:Bradykinin