Bromocriptine lowers intraocular pressure without affecting blood pressure.
Oral bromocriptine (1.25 mg) was given to 8 healthy volunteers in a double-blind placebo controlled cross-over study. 3 and 4 h after taking the tablet there was a significant reduction in intraocular pressure but no change in pupil diameter. There were no changes in heart rate, blood pressure, and systolic time intervals in 6 other healthy volunteers within 3 h of being given 1.25 mg bromocriptine. These results suggest that dopamine receptors may be involved in the control of intraocular pressure.
D001794:Blood Pressure / Q000187:drug effects*; D001971:Bromocriptine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*
D001971:Bromocriptine