Antiviral activity of hetarylhydrazones.
Some hetarylhydrazones showed antiviral activity against Mengo virus in vitro. The replication of influenza A and B viruses was affected neither in vitro (chick chorioallantoic membranes) nor in vivo (mice). Based on dose response curves of the active hetarylhydrazones the compound Z 98/69 appeared most effective in vitro. This compound neither inactivated the extracellular virus nor inhibited its adsorption and penetration; it reduced virus replication when added 1-3 hr after Mengo virus inoculation. As shown by plaque reduction test vaccinia virus was also inhibited. A partial inhibition of rhinovirus 1B multiplication was observed whereas other picornaviruses were not affected.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002642:Chick Embryo; D006801:Humans; D006835:Hydrazones / Q000494:pharmacology*; D008574:Mengovirus / Q000187:drug effects; D009975:Orthomyxoviridae / Q000187:drug effects; D010849:Picornaviridae / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents; D006835:Hydrazones