Neurotoxicity of lanthanum chloride in newborn chicks.
Acute intraperitoneal administration of lanthanum chloride to newborn chicks at the single dose of 250 mg/kg body weight inhibits calcium binding to brain synaptosomal membrane. There is also marked depression in the activities of neural Ca2+-ATPase, Mg2+-ATPase, and cholinesterase after acute lanthanum chloride intoxication. The inhibition of these enzymes in relation to depletion of calcium binding to the synaptosomal membrane has been discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D017301:Ca(2+) Mg(2+)-ATPase; D002118:Calcium / Q000494:pharmacology; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002645:Chickens; D002802:Cholinesterases / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007811:Lanthanum / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D009422:Nervous System Diseases / Q000139:chemically induced*; D013574:Synaptosomes / Q000201:enzymology
C028521:lanthanum chloride; D007811:Lanthanum; D002802:Cholinesterases; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D002118:Calcium