The metabolism and elimination of S-carboxymethyl-L-cysteine in man.
The metabolism of 14C- and 35S-labeled S-carboxymethylcysteine (SCMC) has been compared. The majority of the dose appeared in urine in the first 24 hr; no activity was detectable in feces. Use of 25S-labeled compound gave small amounts of inorganic 35S-sulfate, whereas 14C-labeled material was degraded to give some [14C]urea. Peak excretion of the parent compound occurred first after administration of SCMC; metabolites requiring one chemical modification for their formation were maximally excreted 1-4 hr after the dose and those involving more metabolic processes appeared later (4-8 hr).
D001711:Biotransformation; D002233:Carbocysteine / Q000378:metabolism* / Q000652:urine; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D003545:Cysteine / Q000031:analogs & derivatives*; D005243:Feces / Q000032:analysis; D006801:Humans; D013462:Sulfur Radioisotopes
D002250:Carbon Radioisotopes; D013462:Sulfur Radioisotopes; D002233:Carbocysteine; D003545:Cysteine