Hemoglobin Kariya [alpha 40 (C5) Lys leads to Glu]: a new hemoglobin variant with an increased oxygen affinity.
A new abnormal hemoglobin, Hb Kariya [alpha 40 (C5) Lys leads to Glu], with an amino acid substitution at the alpha 1 beta 2 contact was discovered in a young Japanese man. This variant migrated to the anode faster than Hb A, being nearly the same as Hb I in electrophoretic mobility. It amounted to about 6% of the total hemoglobin of the hemolysate. This hemoglobin showed an increased oxygen affinity, decreased heme-heme interaction and a lowered 2,3-DPG effect.
D000328:Adult; D000596:Amino Acids / Q000032:analysis; D014644:Genetic Variation; D005971:Glutamates; D018698:Glutamic Acid; D006455:Hemoglobins, Abnormal / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008239:Lysine; D008297:Male; D010100:Oxygen / Q000097:blood; D010446:Peptide Fragments / Q000032:analysis
D000596:Amino Acids; D005971:Glutamates; D006455:Hemoglobins, Abnormal; D010446:Peptide Fragments; D018698:Glutamic Acid; C038013:hemoglobin Kariya; D008239:Lysine; D010100:Oxygen