Effect of sympathetic stimulation on inactive renin.
In the present study we investigated the effect of three manoeuvres known to be associated with enhanced sympathetic activity on plasma levels of active and inactive renin. To this end, active and trypsin-activatable renin were measured in blood drawn from 12 untreated essential hypertensive patients before, during and after any of the following tests: isometric exercise (handgrip), noise stimulation and 45 degrees head-up tilt. These studies were repeated after the patients had been treated with either atenolol (n = 6) or SL 77499 (n = 6), an alpha-1 adrenoceptor blocking agent for 10 days. The results indicate that active and inactive renin often change in an unpredictable way in response to sympathetic stimulation. There are, as yet, no conclusive explanations which describe the behaviour of both forms of renin during these manoeuvres.
D000161:Acoustic Stimulation; D000317:Adrenergic alpha-Antagonists; D000328:Adult; D001262:Atenolol; D001794:Blood Pressure / Q000187:drug effects; D004792:Enzyme Precursors / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008875:Middle Aged; D009930:Organic Chemicals; D005082:Physical Exertion; D011187:Posture; D012083:Renin / Q000097:blood*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D000317:Adrenergic alpha-Antagonists; D004792:Enzyme Precursors; D009930:Organic Chemicals; D001262:Atenolol; C036869:SL 77499; D012083:Renin