Leucotrienes, SRS-A and the vascular manifestations of PCA.
In order to study possible mediators of the vascular manifestations of passive cutaneous anaphylaxis (PCA), several arachidonic acid metabolites were injected into guinea-pig skin. SRS-A, LTB4, LTC and LTD increased vascular permeability, responses to LTs being enhanced by PGE2. Mepyramine inhibited responses to histamine, but not those to SRS-A and LTs; the latter were inhibited by the SRS-A antagonist FPL-55712. Both mepyramine and FPL-55712 exert limited inhibitory effects on vascular permeability during PCA. Leukotrienes may contribute towards vascular permeability during PCA.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D012898:Autacoids / Q000502:physiology*; D001798:Blood Proteins / Q000378:metabolism; D001808:Blood Vessels / Q000503:physiopathology*; D015232:Dinoprostone; D006168:Guinea Pigs; D006632:Histamine / Q000502:physiology; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism; D010323:Passive Cutaneous Anaphylaxis; D011458:Prostaglandins E / Q000494:pharmacology; D013189:SRS-A / Q000502:physiology*
D001095:Arachidonic Acids; D012898:Autacoids; D001798:Blood Proteins; D011458:Prostaglandins E; D013189:SRS-A; D016718:Arachidonic Acid; D006632:Histamine; D015232:Dinoprostone