Glutamate and aspartate do not modify the ataxic gait of acrylamide treated animals.
The purpose of this experiment was to examine the effects of intraventricular injections of glutamate and aspartate on the gait of animals rendered ataxic by the administration of acrylamide. Contrary to their previously reported corrective influence on ataxia induced by 3-acetyl pyridine, these amino acids did not modify the ataxic gait of acrylamide treated animals. This suggests that glutamate and aspartate can act in cerebellar but not in peripheral types of ataxia in animals.
D000178:Acrylamides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D005684:Gait; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
D000178:Acrylamides; D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid