Experimental transmission of macaque AIDS by means of inoculation of macaque lymphoma tissue.
Acquired immuno-deficiency syndrome (AIDS) of macaques, an animal model for human AIDS, was transmitted to previously healthy macaque monkeys by means of inoculation of either tissue or a cell-free filtrate of a macaque lymphoma. The recipients showed evidence of profound lymphocyte dysfunction or died with infections from such opportunistic agents as Candida albicans, Cryptosporidium, and cytomegalovirus.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000635:transmission / Q000662:veterinary*; D000818:Animals; D002177:Candidiasis / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D007414:Intestinal Neoplasms / Q000635:transmission; D008223:Lymphoma / Q000635:transmission / Q000662:veterinary*; D008251:Macaca / Q000382:microbiology*; D008252:Macaca fascicularis / Q000382:microbiology*; D008253:Macaca mulatta / Q000382:microbiology*; D008297:Male; D008992:Monkey Diseases / Q000635:transmission*; D009374:Neoplasms, Experimental / Q000635:transmission; D013601:T-Lymphocytes / Q000276:immunology