Isolation and characterization of palystatins A-D.
Four new and relatively low molecular weight (approximately 3,000-5,000), cell growth (PS) inhibitory peptides designated palystatins A-D have been isolated from the Indian Ocean Palythao liscia Haddon and Duerden. The Isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100) guided by bioassay with the P388 murine lymphocytic leukemia (PS system). Palystatins A-D exhibited PS cytotoxicity in the range ED50 0.02-0.0023 microgram/ml.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D003063:Cnidaria / Q000032:analysis*; D006020:Glycopeptides / Q000302:isolation & purification*; D051379:Mice; D008970:Molecular Weight; D009374:Neoplasms, Experimental / Q000188:drug therapy
D000596:Amino Acids; D000970:Antineoplastic Agents; D006020:Glycopeptides; C035113:polystatin