Selective inhibition of thromboxane synthetase by dazoxiben increases prostacyclin production by leukocytes in angina patients and healthy volunteers.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood*; D004311:Double-Blind Method; D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007962:Leukocytes / Q000378:metabolism*; D008875:Middle Aged; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011453:Prostaglandins / Q000096:biosynthesis*; D011897:Random Allocation; D013268:Stimulation, Chemical; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D007093:Imidazoles; D011453:Prostaglandins; C029166:dazoxiben; D011464:Epoprostenol; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase