Neuropeptide Y in phaeochromocytomas and ganglioneuroblastomas.
Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straightforward to measure and relatively stable, its estimation may prove helpful as a screening tests for phaeochromocytoma.
D000310:Adrenal Gland Neoplasms / Q000032:analysis*; D002850:Chromatography, Gel; D005729:Ganglioneuroma / Q000032:analysis*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009478:Neuropeptide Y; D010673:Pheochromocytoma / Q000032:analysis*; D011863:Radioimmunoassay
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y