Generalized lipidosis in newborn rats and Guinea pigs induced during prenatal development by administration of amphiphilic drugs to pregnant animals.
Pregnant rats and guinea pigs were treated throughout the second half of gestation with amphiphilic drugs (chlorphentermine, chlorcyclizine, chloroquine) known to induce generalized lipidosis. The offspring were sacrificed immediately after birth, and several tissues (lung, liver, kidney, spleen, pituitary gland, adrenal gland, spinal cord, hypothalamus) were examined by electron microscopy. Generalized lipidosis was found in the offspring of both species, albeit of lesser degree than in the mothers. The results show that fetal and adult tissues respond to lipidosis-inducing drugs in a qualitatively similar way; the quantitative differences found may be related to pharmacokinetic and cellular factors.
D000311:Adrenal Glands / Q000648:ultrastructure; D000818:Animals; D002738:Chloroquine; D002745:Chlorphentermine; D005260:Female; D006168:Guinea Pigs; D007031:Hypothalamus / Q000648:ultrastructure; D007668:Kidney / Q000648:ultrastructure; D008064:Lipidoses / Q000139:chemically induced*; D008099:Liver / Q000648:ultrastructure; D008168:Lung / Q000648:ultrastructure; D008431:Maternal-Fetal Exchange; D008854:Microscopy, Electron; D010645:Phentermine / Q000031:analogs & derivatives; D010879:Piperazines; D010902:Pituitary Gland / Q000648:ultrastructure; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000648:ultrastructure; D013154:Spleen / Q000648:ultrastructure
D010879:Piperazines; D002738:Chloroquine; D010645:Phentermine; D002745:Chlorphentermine