Cadmium-induced changes in the histoenzymatic activity in liver, kidney and duodenum of pregnant rats.
Cadmium was administered in drinking water at a concentration of 50 ppm to female Wistar rats for 5 months before mating, and then continued during gestation. The histochemical evaluation revealed a relative decrease in succinic dehydrogenase (SDH) and Mg+2-stimulated ATPase activities in duodenum, liver and kidney in the exposed rats. It is suggested that the resulting decrease in metabolic efficiency in maternal organs would be expected to exert an indirect, inhibitive effect on maternal-fetal transfer of nutrients, as reflected by fetal growth retardation.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D002104:Cadmium / Q000633:toxicity*; D003300:Copper / Q000378:metabolism; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology*; D005260:Female; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D002104:Cadmium; D003300:Copper; D007501:Iron; D013385:Succinate Dehydrogenase; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D015032:Zinc