Mercapturic acid pathway enzymes in bovine ocular lens, cornea, retina and retinal pigmented epithelium.
Analogous to the liver, ocular tissues contain large concentrations of glutathione and are exposed to potentially damaging chemical compounds. Since glutathione has been shown to have a detoxification function, via mercapturic acid production in the liver, we investigated whether glutathione has a similar function in ocular tissues. We have demonstrated the presence of all of the enzymes involved in the mercapturic acid pathway i.e. glutathione S-transferase, gamma-glutamyl transpeptidase, cysteinylglycinase, and N-acetyl transferase, in the ocular tissues of bovine lens, cornea, retina, and retinal pigmented epithelium. Therefore glutathione may have another function in ocular tissues, that of the detoxification of xenobiotics.
D000111:Acetylcysteine / Q000502:physiology*; D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D002417:Cattle; D003315:Cornea / Q000201:enzymology*; D004150:Dipeptidases / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007908:Lens, Crystalline / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D010857:Pigment Epithelium of Eye / Q000201:enzymology*; D012160:Retina / Q000201:enzymology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D000123:Acetyltransferases; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; C019974:cysteinyl-glycine dipeptidase; D004150:Dipeptidases; D000111:Acetylcysteine