The prolonged retention of sodium cromoglycate in the rabbit eye.
The retention of sodium cromoglycate in the rabbit eye over a 6 h period following its administration in two different vehicles is reported. When formulated as a dispersion in a hypo-allergenic acetylated lanolin/paraffins base, prolonged retention was observed. Thus, the concentration of sodium cromoglycate in the tears, conjunctiva and cornea 6 h after administration equalled or exceeded the concentration obtained with an aqueous solution 1 h post-instillation.
D000818:Animals; D003228:Conjunctiva / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000378:metabolism*; D005123:Eye / Q000378:metabolism*; D011817:Rabbits; D013666:Tears / Q000378:metabolism
D004205:Cromolyn Sodium