Low forestomach acidity in the rat and the role of the gastric bolus.
pH measurements were recorded from the mucosal surfaces of the rat forestomach and glandular stomach following stimulation of acid-secretion by pentagastrin. Animals containing a normal gastric bolus showed lower forestomach acidity (pH 4.3, cf. 3.2) as did coprophagic animals that contained a fecal gastric bolus (pH 6.0, cf. 3.6). Animals without a gastric bolus showed higher forestomach acidity (pH 2.3, cf. 3.0). It is concluded that the presence of a food bolus is prerequisite to maintenance of lower forestomach acidity in rats.
D000818:Animals; D003303:Coprophagia / Q000378:metabolism; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism; D013270:Stomach / Q000033:anatomy & histology; D014018:Tissue Distribution