Co-existence of thyrotrophin releasing hormone and 5-hydroxytryptamine in the skin of Xenopus laevis.
1. The location, release and re-synthesis of thyrotrophin releasing hormone (TRH) and 5-hydroxytryptamine (5-HT) in the skin of Xenopus laevis (the South African clawed toad) have been determined using both morphological and analytical procedures. 2. High levels of TRH and 5-HT are located specifically within the dermal granular glands of X. laevis and discharged from these glands following alpha-adrenergic stimulation. 4. The common occurrence and separate production of high levels of TRH and 5-HT in amphibian skin may provide a model for studying the mechanisms of biosynthesis, interaction and release of these substances in mammalian tissues such as ventral spinal cord, where TRH and 5-HT are found in the same neurones.
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D012701:Serotonin / Q000378:metabolism*; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*; D014982:Xenopus laevis / Q000378:metabolism*
D012701:Serotonin; D013973:Thyrotropin-Releasing Hormone; D004837:Epinephrine