[Stimulation of antigen Thy-1 expression in mouse bone marrow cells by thymus extracts].
The expression of antigen Thy-1 was studied in bone marrow cells of CBA line mice under the effect of thymus extracts. Extracts of the calf thymus--thymosine (fraction 5) and the preparation free of the Comsa factor were obtained by a combination of the Goldstein and Comsa extraction methods. The both extracts stimulate the expression of antigen Thy-1 in bone marrow cells. Incorporation of [14 C]sodium acetate into fragments containing antigen Thy-1 and absorbed by the column with anti-Thy-1-antibodies remains unchanged after stimulation. It is supposed that antigen Thy-1 ability to stimulate expression in bone marrow precursors of T-cells is not due to the synthesis of the antigen and is a property of one of the thymus factors with molecular mass of about 5000.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D002417:Cattle; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D051379:Mice; D008808:Mice, Inbred CBA; D011817:Rabbits; D018800:Thy-1 Antigens; D013947:Thymosin / Q000276:immunology*; D013949:Thymus Extracts / Q000276:immunology* / Q000302:isolation & purification; D013951:Thymus Hormones / Q000276:immunology*
D000954:Antigens, Surface; D018800:Thy-1 Antigens; D013949:Thymus Extracts; D013951:Thymus Hormones; D013947:Thymosin
Stimuliatsiia ékspressii antigena Thy-1 kletok kostnogo mozga mysheĭ ékstraktami timusa.