Comparison of effects of adrenaline, ethylphenylephrine, isoprenaline and terbutaline on the vascular system.
The effects of a single therapeutic dose of sympathomimetics, adrenaline, ethylphenylephrine, isoprenaline and terbutaline on venous return and other peripheral vascular beds were compared in dogs subjected to controlled cardiac output. The intra-aortic administration of adrenaline (1 microgram/kg) produced increases in femoral arterial pressure (FAP), left auricular outflow (LAO) and superior vena-caval flow (S-VCF), while no significant change was observed in inferior vena-caval flow (I-VCF) and femoral venous pressure. Ethylphenylephrine (0.4 mg/kg), a selective alpha-adrenoceptor stimulant, showed almost the same pattern of change but of smaller magnitude as adrenaline, though the duration of the effect was longer. Isoprenaline (1 microgram/kg) showed decreases in FAP and LAO, and marked increases in S-VCF and I-VCF. Terbutaline (20 microgram/kg), a beta2-adrenoceptor stimulant, showed no significant effect on LAO, though other parameters changed with the same pattern produced by isoprenaline.
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D005039:Etilefrine / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*; D013726:Terbutaline / Q000494:pharmacology
D013566:Sympathomimetics; D007545:Isoproterenol; D013726:Terbutaline; D004837:Epinephrine; D005039:Etilefrine