title: Hypotensive mechanisms of beta blockers.
abstract: A review of the available evidence suggests that the antihypertensive action of beta blockers depends partly upon a reduction in plasma renin activity. Since there are abnormalities of cardiac function in hypertension the reduction in cardiac output and heart rate may also contribute to the fall in blood pressure.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D011453:Prostaglandins / Q000378:metabolism; D012083:Renin / Q000097:blood; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D011453:Prostaglandins; D012083:Renin