Hypertensive effect of yohimbine following selective injection into the nucleus tractus solitarii of normotensive rats.
We administered yohimbine (0.5 nmol in 0.2 microliter) directly into the nucleus tractus solitarii (NTS) of urethane-anesthetized normotensive male rats. We noted a prompt rise in blood pressure which lasted 30 min. These data suggest that the NTS is a central site in which the hypertensive effects of yohimbine can originate.
D000317:Adrenergic alpha-Antagonists; D000818:Animals; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D015016:Yohimbine / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D015016:Yohimbine