Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.
D000818:Animals; D019328:Buthionine Sulfoximine; D005721:Glutamate-Cysteine Ligase / Q000037:antagonists & inhibitors*; D005978:Glutathione / Q000096:biosynthesis*; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013552:Swine
D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D010453:Peptide Synthases; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione