[Effect of combination of inderal with nitrites on the contractile function of the heart in experimental coronary occlusion].
In acute experiments on 29 dogs with coronary occlusion changes in cardiohaemodynamics, epicardial electrogram and the regional contractility of the myocardium were studied with the aid of echocardiography after combined administration of inderal with nitroglycerin or sodium nitroprusside. It was established that under these conditions nitrites retain their ability to decrease the load on the heart: they decrease the end diastolic pressure and the volume of the cavity of the left ventricle, enhance the productivity of the heart Nitrites given with inderal do not change the contractility of the ischemized area and also do not affect the magnitude of the rise of ST segment of the epicardium electrogram of the ischaemic zone. It is concluded that the use of nitrites in acute myocardial ischaemia combined with inderal is justified to decrease congestive insufficiency of the heart, excepting cases with marked hypotension.
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005292:Ferricyanides / Q000008:administration & dosage*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D005996:Nitroglycerin / Q000008:administration & dosage*; D009599:Nitroprusside / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage*
D000319:Adrenergic beta-Antagonists; D005292:Ferricyanides; D009599:Nitroprusside; D011433:Propranolol; D005996:Nitroglycerin
Vliianie kombinatsii inderala s nitritami na sokratitel'nuiu funktsiiu serdtsa pri eksperimental'noĭ koronarnoĭ okkliuzii.