Simultaneous application of influenza chemovaccine and "Vaxigrip" preparations with BCG.
Experiments in guinea pigs and rabbits have shown that simultaneous immunization against influenza and tuberculosis had no effect on the reactogenic properties of both vaccines. No inhibitory effect of the BCG vaccine on the influenza virus antibody production was observed. Production of antituberculosis antibodies was the most intensive following a simultaneous immunization of animals with BCG and inactivated influenza vaccines. Both separate and simultaneous immunization conferred to animals a similar grade of protection against virulent tuberculosis mycobacteria. Application of the combined preparation "Vaxigrip" & BCG (in mixture) caused complicated local reactions and had little immunogenic effect.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000914:Antibodies, Viral / Q000096:biosynthesis; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D006168:Guinea Pigs; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011817:Rabbits
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D001500:BCG Vaccine; D007252:Influenza Vaccines