Excellent outcome after transplantation of renal allografts from HLA-DRw6-positive donors even in HLA-DR mismatches.
The effect of the presence or absence in the donor of HLA-DRw6 on the survival of renal allografts was studied in 759 HLA-DRw6-negative recipients. The definition of HLA-DRw6 was consistent throughout the study period. 578 patients received an allograft with one HLA-DR mismatch and 181 an allograft with two HLA-DR mismatches. Allograft survival at 1 year was significantly better when the donors were HLA-DRw6-positive than when they were HLA-DRw6-negative, for both one-DR-mismatched (86% vs 65%) and two-DR-mismatched (85% vs 59%) allografts.
D003601:Cytotoxicity Tests, Immunologic; D005500:Follow-Up Studies; D005787:Gene Frequency; D005802:Genes, MHC Class II; D006085:Graft Survival; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation
D000949:Histocompatibility Antigens Class II