Effect of a new analeptic drug, almitrine, on fentanyl-induced respiratory depression and analgesia in man.
Five female patients received fentanyl 0.0066 mg kg-1 i.v. (group A); five other female patients received the same dose of fentanyl, followed immediately by almitrine 0.5 mg kg-1 i.v. (group B) and 20 minor gynaecological operations were performed under a combination of almitrine 0.5 mg kg-1 and fentanyl 0.0066 mg kg-1 (group C). In group A, fentanyl produced a marked and significant respiratory depression (P less than 0.001). In group B and C, almitrine antagonized the fentanyl-induced respiratory depression. Analgesia did not seem to be affected.
D000328:Adult; D015765:Almitrine; D000698:Analgesia; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D005283:Fentanyl / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D010879:Piperazines / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
D000697:Central Nervous System Stimulants; D010879:Piperazines; D015765:Almitrine; D005283:Fentanyl