title: Huntington's disease: new approaches to an old problem. The Robert Wartenberg lecture.
abstract: Huntington's disease (HD) is an autosomal dominant disorder of midlife onset, characterized by progressive involuntary choreiform movements, psychologic change, and dementia. In 1980, funded by the NINCDS, we established a center for the study of HD. This report presents a summary of our contributions to the investigation of this tragic disorder and a review of current ideas about the disease.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000328:Adult; D000367:Age Factors; D001479:Basal Ganglia / Q000378:metabolism / Q000473:pathology; D004247:DNA / Q000235:genetics; D004298:Dopamine / Q000378:metabolism; D005799:Genes, Dominant; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D011110:Polymorphism, Genetic; D011296:Prenatal Diagnosis; D013004:Somatostatin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005971:Glutamates; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D004247:DNA; D000109:Acetylcholine; D004298:Dopamine