title: Effect of caerulein administration on portal plasma somatostatin in dogs.
abstract: The effect of administration of synthetic caerulein on canine plasma somatostatin concentration in the portal vein was investigated using specific radioimmunoassay of acid-acetone extracted plasma. Gel chromatography revealed that the main component of the plasma somatostatin in the portal vein was identical with somatostatin-14. After administration of caerulein (5 ng/kg), the somatostatin level increased significantly while the gastrin level remained unchanged. These results suggested that caerulein affects D cell function but not gastrin secretion.
mesh_terms: D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D004285:Dogs; D011169:Portal Vein; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood*
chemical_list: D013004:Somatostatin; D002108:Ceruletide