title: Old and new inotropic drugs.
abstract: An ideal cardiotonic agent should improve cardiac contractility and increase the oxygen supply to various tissues without inducing tachycardia, arrhythmias, decrease in coronary blood flow or increment in oxygen requirements of the myocardium. It should also be safe and orally active and have a persistent action. The aim of this paper is to describe various positive inotropic drugs at our disposal. The hemodynamic effects and the indications of adrenaline, noradrenaline, isoprenaline, dopamine, dobutamine and cardiac glycosides are presented first. Then several new promising orally active compounds are discussed.
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000631:Aminopyridines / Q000494:pharmacology; D000676:Amrinone; D002301:Cardiac Glycosides / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D002395:Catecholamines / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D011217:Practolol / Q000031:analogs & derivatives / Q000494:pharmacology; D011294:Prenalterol; D011412:Propanolamines / Q000494:pharmacology; D013268:Stimulation, Chemical; D017307:Xamoterol
chemical_list: D000318:Adrenergic beta-Agonists; D000631:Aminopyridines; D002301:Cardiac Glycosides; D002316:Cardiotonic Agents; D002395:Catecholamines; D007093:Imidazoles; D011412:Propanolamines; D017307:Xamoterol; D005934:Glucagon; C029758:sulmazole; D000676:Amrinone; D007545:Isoproterenol; D011294:Prenalterol; D011217:Practolol