Insulin inhibition of tyrosine aminotransferase induction by dexamethasone is species-related.
Dexamethasone induces TAT in the embryonic chick liver, but this effect is not blocked by prior administration of insulin at a dose sufficient to increase the hepatic protein/DNA ratio. Similarly, insulin does not block dexamethasone induction of TAT in chick embryo hepatocytes in vitro. In contrast, insulin reduces TAT induction by dexamethasone in fetal rat hepatocytes by 35-40%. No significant differences in insulin binding were noted between chick and rat hepatocytes.
D000818:Animals; D002642:Chick Embryo; D003907:Dexamethasone / Q000037:antagonists & inhibitors*; D004790:Enzyme Induction; D005260:Female; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D013045:Species Specificity; D013997:Time Factors; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D007328:Insulin; D003907:Dexamethasone; D014444:Tyrosine Transaminase