[Correlation of dopamin- and GABA-ergic mechanisms in the depressive effect of neuroleptics on pedal self-stimulation of the ventral tegmentum of the mesencephalon].
Inhibition of self-stimulation of the ventral tegmentum in male rats with droperidol, haloperidol, trifluoroperazine and chlorpromazine is realized by dopamin- and GABA-ergic mechanisms of the emotional-positive reinforcement system. The GABA-ergic rather than dopaminergic mechanisms of the positive reinforcement systems realize the fluphenazine-induced reduction of self-stimulation of the midbrain ventral tegmentum. Analogous effects of clozapine and thioridazine are realized outside the dopamin- and GABA-ergic mechanisms of the reinforcement system.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism*; D004644:Emotions / Q000187:drug effects; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects*; D011963:Receptors, GABA-A; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects*; D013681:Tegmentum Mesencephali / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D014150:Antipsychotic Agents; D011956:Receptors, Cell Surface; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D004298:Dopamine
O sootnoshenii dofamin- i GAMK-ergicheskikh mekhanizmov v ugnetaiushchem vliianii neĭroleptikov na pedal'nuiu samostimuliatsiiu ventral'noĭ pokryshki srednego mozga.