Assessment of left-ventricular mass and its response to antihypertensive treatment.
50 patients with mild to moderate essential hypertension underwent M-mode echocardiography and continuous intra-arterial ambulatory monitoring of blood pressure. Indices of left-ventricular (LV) mass were derived from echocardiographic data by standard formulae. 43 of the patients were followed up for 12+/-7 months with repeat M-mode echocardiography, and casual blood-pressure measurements. 25 of these patients received antihypertensive therapy and 18 were untreated. Mean 24 h systolic blood pressure was significantly correlated with echocardiographic LV mass; mean 24 h diastolic blood pressure was also correlated, but the relation was weaker. In the treated group there was a significantly greater fall in blood pressure and LV mass index than in the untreated group, and there was a significant correlation between the fall in systolic blood pressure and the fall in LV mass index in the treated group. Systolic blood pressure appears to be an important factor in the pathogenesis of LV hypertrophy, and in hypertensive patients changes in LV mass assessed by echocardiography correlate with changes in blood pressure.
D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D006332:Cardiomegaly / Q000175:diagnosis / Q000209:etiology*; D004452:Echocardiography / Q000295:instrumentation; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013599:Systole / Q000187:drug effects
D000959:Antihypertensive Agents