title: [Indications and contraindications of beta blockaders in the treatment of glaucoma].
abstract: Local administration of beta-blockers to the eye has proven effective in the treatment of chronic simple glaucoma. However, varying degrees of impaired ventilation, even to the point of being life-threatening, have been reported. The effect of 1% pindolol and 0.5% timolol eye-drops, twice daily applied locally to the eye, on eyeball pressure and airway resistance was measured in 19 patients with chronic glaucoma. Compared with timolol eye-drops, pindolol had little effect on ventilatory functions, i. e. there was a significant difference between them. But the two preparations had similar effects in lowering eye-ball pressure. The likely explanation of this divergent action is the intrinsic sympathomimetic activity of pindolol.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010869:Pindolol / Q000008:administration & dosage; D012119:Respiration / Q000187:drug effects; D013999:Timolol / Q000008:administration & dosage
chemical_list: D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; D013999:Timolol; D010869:Pindolol
vernacular_title: Indikation und Kontraindikation der beta-Blocker zur Glaukombehandlung.