Relation between the antihistaminic effect and the alpha-adrenolytic one of thymoxamine.
Thymoxamine, suggested by some authors as a useful drug in the asthma therapy associated with beta-adreno-stimulant agents, tested on smooth tracheal muscle of guinea-pig, showed a stronger antihistaminic activity compared to the alpha-adrenolytic action.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D013948:Moxisylyte / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects
D006634:Histamine H1 Antagonists; D011942:Receptors, Adrenergic, alpha; D013948:Moxisylyte; D009638:Norepinephrine