Change in ratio of the two hepatic isometallothioneins with development from prenatal to neonatal rats.
Concentrations and contents of essential metals in the livers of prenatal and neonatal rats were determined simultaneously by inductively coupled plasma-atomic emission spectrometry. The concentrations and contents changed with development in a mode characteristic to the respective metals. Changes in the concentrations and contents of zinc and copper were correlated to those bound to metallothionein, the two metals being high in concentration during prenatal and neonatal periods. The relative ratio of the two isoforms of metallothionein changed with development, the form I being predominant in prenatal livers.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D005865:Gestational Age; D008099:Liver / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism*; D051381:Rats; D015032:Zinc / Q000378:metabolism
D003300:Copper; D008668:Metallothionein; D015032:Zinc