title: Effect of L-tryptophan supplementation on ischemic pain.
abstract: The synthesis of neurotransmitter amines in mammalian brain is known to respond to changes in precursor availability. After dietary manipulation including L-tryptophan supplementation 3 subjects out of 11 showed a significant reduction of experimentally induced ischemic pain. It is suggested that dietary manipulation aimed at an increase in central nervous system serotonin can alter pain perception in some individuals.
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood; D001132:Arm / Q000098:blood supply*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000097:blood / Q000188:drug therapy*; D014364:Tryptophan / Q000097:blood / Q000627:therapeutic use*
chemical_list: D000596:Amino Acids; D014364:Tryptophan