[Drug therapy and prevention of acute upper gastrointestinal hemorrhage].
As medical treatment of haemorrhage from esophageal varices vasopressin is discussed. The analogue triglycyl-vasopressin has less side-effects and a longer plasma half-life. According to the first randomized study with only a small number of patients bleeding from varices triglycyl-vasopressin was superior to vasopressin. The efficacy of somatostatin to reduce splanchnic blood flow in patients with liver cirrhosis is controversial. In a placebo-controlled trial propranolol prevented rebleeding from varices in patients with cirrhosis. However, beta-blockers should not be given to patients with advanced cirrhosis. Several controlled studies prove cimetidine not to be effective in ulcer bleeding. Somatostatin and secretin could be candidates for pharmacotherapy of haemorrhage from ulcers and erosions. In an own randomized and multicenter trial on 100 patients with stopped ulcer bleeding it was proven that the combination of the synergistically acting receptor antagonists cimetidine and pirenzepine prevent rebleeding significantly better than a prophylactic treatment of either cimetidine or pirenzepine alone. An improvement of mortality rates of upper gastrointestinal bleeding seems also to be possible by using such a combined prophylaxis. As prophylaxis of stress-ulcer bleeding cimetidine - recently ranitidine, too - and antacids are applied. Instead of a widely used enhancement of the doses of H2-blockers a combined application of H2-receptor antagonists and pirenzepine is also recommended in this indication which offers theoretical and practical advantages.
D000208:Acute Disease; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002927:Cimetidine / Q000627:therapeutic use; D004932:Esophageal and Gastric Varices / Q000188:drug therapy; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control; D012008:Recurrence; D013004:Somatostatin / Q000627:therapeutic use; D014667:Vasopressins / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D014667:Vasopressins; D013004:Somatostatin; D002927:Cimetidine
Pharmakotherapie und Prophylaxe der akuten oberen gastrointestinalen Blutung.