title: Intraocular pressure reduction induced by hornet venom in the normal eye.
abstract: Intravenous injection into rabbits and cats of an aqueous extract of hornet venom sac, produced a significant reduction in the intraocular pressure. The mean reduction of the ocular pressure was between 7 and 15 mm Hg within one hour past injection and it lasted 6-12 h or in several instances even more than 24 h. The effect is produced by some thermolabile high-molecular-weight fraction(s), is dose-dependent and is reproducible by repetitive injections. Side effects may include diarrhea, micturition and lethargy, but usually there is no marked effect on the size of the pupil.
mesh_terms: D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D007429:Intraocular Pressure; D011817:Rabbits; D013997:Time Factors; D014862:Wasp Venoms / Q000494:pharmacology*
chemical_list: D001514:Bee Venoms; D014862:Wasp Venoms