Coexistence of substances related to enkephalin and somatostatin in granules of the guinea-pig median eminence: demonstration by use of colloidal gold immunocytochemical methods.
Using two different immunocytochemical approaches at the electron microscopic level, it was shown that substances related to enkephalin and somatostatin coexist in the same granules in the median eminence of the guinea-pig. This finding means that the two neuropeptides are simultaneously released. The possible inhibiting action of enkephalins on somatostatin release is discussed related to other data.
D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism*; D006168:Guinea Pigs; D007124:Immunoenzyme Techniques; D008473:Median Eminence / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*
D004745:Enkephalins; D013004:Somatostatin; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine