[Table for determining minimal toxic dosage].
The authors suggest a rapid, simple and economical method for the measurement of the minimal toxic dose for the drugs with marked dose-effect dependence. The method is based on the use of the precalculated tables, with minimal consumption of laboratory animals. The data obtained, while providing for statistical significance, make it possible to measure, as the minimal toxic dose, the TD10 rather than the TD16, which raises the method sensitivity.
D000654:Amobarbital / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000633:toxicity; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D008722:Methods; D051379:Mice; D011336:Probability
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D000654:Amobarbital
Tablichnyĭ metod opredeleniia minimal'noĭ toksicheskoĭ dozy.