Presence and characterization of prolactin receptors in human benign breast tumours.
Prolactin receptors have been determined in 64 benign breast tumours. A specific binding of 0.5% or more (with a range of 0.5-3.3%) was found in 34.4% of the cases and was considered prolactin-receptor-positive. The binding was found to be specific only for lactogenic hormones. By Scatchard analysis the dissociation constant was 2.55 X 10(-10) mol/l and the binding capacity was 4.6 fmol/mg protein.
D000232:Adenofibroma / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000032:analysis; D006177:Gynecomastia / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000032:analysis*; D011956:Receptors, Cell Surface / Q000032:analysis*; D011981:Receptors, Prolactin
D011956:Receptors, Cell Surface; D011981:Receptors, Prolactin; D011388:Prolactin