Evidence that drugs increasing 5-hydroxytryptamine transmission block jumping but not wet dog shakes in morphine-abstinent rats: a comparison with clonidine.
(+)-Fenfluramine, a 5-hydroxytryptamine (5-HT) releaser and uptake blocker, m-chlorophenylpiperazine (CPP), a 5-HT receptor agonist, and clonidine, an agonist at adrenoceptors, were studied for their ability to modify jumping and wet dog shakes in morphine abstinent rats. (+)-Fenfluramine and CPP blocked jumping with no effect on wet dog shakes whereas the reverse was true for clonidine. The results further show that 5-HT mechanisms are preferentially involved in the expression of jumping in morphine-abstinent rats.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D005277:Fenfluramine / Q000494:pharmacology; D006801:Humans; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
D010879:Piperazines; D011985:Receptors, Serotonin; D005277:Fenfluramine; D009020:Morphine; D003000:Clonidine; C015068:1-(3-chlorophenyl)piperazine