Cytomegalovirus infection of the uterine cervix: local cervical infection and antibody response.
Thirty-three women were examined on three or more occasions, each at 2-month intervals. The overall recovery rate of cytomegalovirus (CMV) was 28% (60/215). CMV was recovered from 53% of the cases where the local antibody was 1 : 64 or greater but the greatest difference occurred below titers of 1 : 32. Below that level virus was recovered in less than 5%, compared to a prevalence of 35% for cases with a titer of 1 : 32 (P less than 0.001). Twenty-eight cases in whom CMV was sought underwent colposcopy examination and had cytologic smears examined by the papanicolaou method. The external uterine cervix with columnar cells only yield a CMV prevalence of 3/17 (18%). However, if colposcopy showed either atypical transformation or metaplasia the prevalence was 4/11 (36%). Similarly, it is provocative that the prevalence of CMV appears to increase with abnormal cytologic findings to 33% recovery in severe dysplasia or carcinoma in situ.
D000914:Antibodies, Viral / Q000276:immunology; D001706:Biopsy; D001826:Body Fluids / Q000276:immunology; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology; D003464:Culdoscopy; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D008679:Metaplasia; D065006:Papanicolaou Test; D002577:Uterine Cervical Diseases / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D014626:Vaginal Smears
D000914:Antibodies, Viral