Autoregulation of the coronary vascular resistance after beta-adrenergic receptor blockade.
It was previously observed that at the beginning of a 10 sec multiple arterial haemorrhage, vascular elasticity induces an increase of coronary vascular resistance, which in the late part of the haemorrhage is counteracted by the relaxation of the vascular smooth muscle fibres. In the present study the effect of multiple arterial haemorrhage on the coronary vascular resistance was studied after beta-adrenergic receptor blockade. The results suggest that also in these circumstances an elastic mechanism precedes a myogenic mechanism in the regulation of coronary vascular resistance.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006470:Hemorrhage / Q000503:physiopathology; D006706:Homeostasis / Q000187:drug effects; D011311:Pressoreceptors / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D011433:Propranolol