title: The hydroxy-hexanydronaphthoxazines: a new group of very potent and selective dopamine agonists.
abstract: Replacement of the pyrrole ring system in the dopaminergic oxaergolines (e.g. RU 29717) by a phenolic OH group leads to the hydroxy-hexahydronaphthoxazines, a new group of potent dopamine agonists which exhibit increased selectivity due to their lower affinity for adrenergic and 5-HT receptors.
mesh_terms: D015107:4-Butyrolactone / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003000:Clonidine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004873:Ergolines / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008803:Mianserin / Q000378:metabolism; D010078:Oxazines / Q000494:pharmacology*; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: C043445:4-propyl-7-hydroxy-1,2,3,4a,5,6-hexahydronaphthoxazine; D004873:Ergolines; D010078:Oxazines; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; C042631:naxagolide; D008803:Mianserin; C037493:N-propyl-9-oxaergoline; D003000:Clonidine; D015107:4-Butyrolactone; D004298:Dopamine; D006719:Homovanillic Acid; D011224:Prazosin