Stimulated release of 3H-glycine from retina.
The release of 3H-glycine was studied from rabbit retinas. Kainic acid (10(-5) M), a glutamate agonist, evoked prompt CA2+-dependent increased release of 3H-glycine. However, nuciferine (10(-4) M) could not suppress the effect of kainic acid. The effect of glutamic acid (10(-5) M) was significantly reduced in the presence of nuciferine (10(-4) M). The GABA analogues, muscimol and THIP, had no effect on the release of 3H-glycine. Aspartate and cystic acid were also without effect.
D000818:Animals; D001060:Aporphines / Q000494:pharmacology; D001224:Aspartic Acid / Q000494:pharmacology; D003544:Cysteic Acid / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D005998:Glycine / Q000378:metabolism*; D066298:In Vitro Techniques; D007555:Isoxazoles / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D009118:Muscimol / Q000494:pharmacology; D011817:Rabbits; D012160:Retina / Q000378:metabolism*
D001060:Aporphines; D005971:Glutamates; D007555:Isoxazoles; D009118:Muscimol; D001224:Aspartic Acid; D018698:Glutamic Acid; D003544:Cysteic Acid; C015542:gaboxadol; D007608:Kainic Acid; D005998:Glycine; C008692:nuciferine