title: Fine-needle intrarenal manometry: a new test for rejection in cyclosporin-treated recipients of kidney transplants.
abstract: Intrarenal pressure was measured in kidney-transplant recipients in an attempt to differentiate between graft rejection and cyclosporin nephrotoxicity. Intrarenal pressure was measured directly through a fine needle inserted into the kidney and connected to a manometer. Blood cyclosporin levels were monitored regularly, and renal biopsy specimens were obtained whenever renal function deteriorated. 32 recipients of renal allografts were studied 1 to 270 days after transplantation. 129 pressure readings were obtained during normal renal function, rejection, nephrotoxicity, and acute tubular necrosis (ATN). Rejection but not toxicity or ATN caused a highly significant rise in intrarenal pressure. No complications were encountered apart from transient haematuria in 1 patient. This simple test may therefore be of value in monitoring renal-transplant patients who are receiving cyclosporin.
mesh_terms: D001794:Blood Pressure; D003524:Cyclosporins / Q000009:adverse effects*; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D016030:Kidney Transplantation; D007683:Kidney Tubular Necrosis, Acute / Q000175:diagnosis / Q000209:etiology; D008365:Manometry / Q000295:instrumentation / Q000379:methods; D009339:Needles; D011312:Pressure
chemical_list: D003524:Cyclosporins