Rat lymphoid leukemia of T cell type induced by 7,12-dimethylbenz(alpha)anthracene. Immunological and enzymological characterization.
Lymphoid leukemia induced by 7,12-dimethylbenz(alpha)anthracene (DMBA) in rats and maintained by serial intraperitoneal transplantations in newborn rats was subjected to immunological and enzymological characterization. The Thy-1 antigen positivity rendered evidence for the T cell origin of the leukemia studied. Expression of cell surface complement binding receptors and patterns of cytoplasmic acid phosphatase and nonspecific acid alpha-naphthyl acetate esterase enzymes drew the attention to the dominance of lymphoblasts and prolymphocytes.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D005455:Fluorescent Antibody Technique; D007942:Leukemia, Experimental / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000139:chemically induced / Q000201:enzymology / Q000276:immunology*; D008565:Membrane Proteins / Q000032:analysis; D009283:Naphthol AS D Esterase / Q000032:analysis; D051381:Rats; D011951:Receptors, Complement / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D008565:Membrane Proteins; D011951:Receptors, Complement; D011961:Receptors, Fc; D018800:Thy-1 Antigens; D015127:9,10-Dimethyl-1,2-benzanthracene; D009283:Naphthol AS D Esterase; D000135:Acid Phosphatase