Fiber splitting in tonic and phasic skeletal muscles following denervation, chloroquine and triton WR-1339 treatments.
Fiber splitting was studied in the tonic, anterior (ALD) and phasic, posterior (PLD) latissimus dorsi muscles using three experimental models, denervation, chloroquine administration and Triton WR-1339 administration. Fiber splitting was observed in the PLD in all three models, but in the ALD only after chloroquine administration. A basement membrane was always present in the split fibers, and acid phosphatase was localized between the split fibers in the PLD. However, no evidence of lysosomal involvement in the fiber splitting process was observed.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D002645:Chickens; D002738:Chloroquine / Q000494:pharmacology; D008247:Lysosomes / Q000648:ultrastructure; D008854:Microscopy, Electron; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D011092:Polyethylene Glycols / Q000494:pharmacology
D011092:Polyethylene Glycols; D002738:Chloroquine; D000135:Acid Phosphatase; C016811:tyloxapol