title: A calcium-dependent transient outward current in Xenopus laevis oocytes.
abstract: Membrane currents were investigated in Xenopus laevis oocytes under voltage clamp. Depolarizing pulses, given from a holding potential of about-100 mV, elicited a transient outward current when the membrane potential was made more positive than about-20 mV. As the potential was made increasingly positive the transient outward current first increased and then decreased. The amplitude of the transient current increased when the external Ca2+ concentration was raised; and the current was abolished by Mn2+. It appears that when the membrane is depolarized Ca2+ ions enter the oocyte and trigger an outward current, possibly by opening C1- channels.
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D005260:Female; D007473:Ion Channels / Q000502:physiology; D007700:Kinetics; D009865:Oocytes / Q000502:physiology*; D010063:Ovum / Q000502:physiology*; D014982:Xenopus laevis
chemical_list: D007473:Ion Channels; D002118:Calcium