Controlled release of radioprotective agents from matrix tablets--effect of preparative conditions on release rates.
Release rates of radioprotective agents from insoluble matrix tablets were measured as a function of ethylcellulose/stearic acid ratio and active ingredient concentration in the matrix. The influence of the compacting pressure applied during tablet formation on the release of these aminothiol compounds was also examined. The kinetic data conformed with the Higuchi square root equation and first order release. As both plots were linearly acceptable, a statistical method for release mechanism identification using the kinetic experimental results obtained without any further transformation was used. This non-linear regression search procedure accompanied by the chi 2-square test has shown that that aminothiol release from the matrix tablets definitely follows the Higuchi square root equation. Increasing the ethylcellulose amount in the matrix consequently improves the degree of wettability and leads to a faster rate of solvent penetration. This tends to release the aminothiols more rapidly from the matrix tablets. Solvent penetration, which also follows a square root of time relationship, is probably the rate-limiting factor in the release process. The linear increase in release rates of the aminothiols observed with ethylcellulose concentration is explained by a parallel increase in the porosity of the matrix tablets. Increase in the drug concentration in the tablet increases the cysteine hydrochloride release rate and decreases the cysteamine hydrochloride release rate. A similar effect was also observed by applying increasing compacting pressure during matrix tablet formation. It was suggested that these two experimental factors differently affect the internal structure of the matrix during the preparation process.(ABSTRACT TRUNCATED AT 250 WORDS)
D002482:Cellulose / Q000031:analogs & derivatives / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D003543:Cysteamine / Q000008:administration & dosage; D003545:Cysteine / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010316:Particle Size; D011312:Pressure; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D014783:Viscosity
D003692:Delayed-Action Preparations; D011837:Radiation-Protective Agents; D003543:Cysteamine; C013517:ethyl cellulose; D002482:Cellulose; D003545:Cysteine