Platelet phenolsulphotransferase deficiency in dietary migraine.
Patients with dietary migraine were found to have significantly lower levels of platelet phenolsulphotransferase activity than either migrainous patients without a history of dietary provocation or normal controls. Of the two known human variants of this enzyme, the phenol-inactivating P form, for which no endogenous substrate has so far been identified, was more severely involved than the M enzyme, which inactivates monoamines (including tyramine). Such commonly implicated dietary triggering agents as chocolate and cheese may contain as-yet-unidentified phenolic substrates of phenolsulphotransferase P; if the platelet enzyme deficiency were mirrored by low gut activity, abnormally large amounts of potentially toxic substances might gain access to the circulation in consequence.
D000328:Adult; D015239:Arylsulfotransferase; D001792:Blood Platelets / Q000201:enzymology*; D004032:Diet / Q000009:adverse effects*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000201:enzymology* / Q000209:etiology; D008995:Monoamine Oxidase / Q000378:metabolism; D013466:Sulfurtransferases / Q000172:deficiency*
D008995:Monoamine Oxidase; D013466:Sulfurtransferases; D015239:Arylsulfotransferase