Chronic non-cytopathic infection of human continuous cell lines with mumps virus.
Chronic infection with a vaccine strain of mumps virus (MV) was produced and studied in human cell cultures L-41 and HEp-2. The establishment and course of the infection was not accompanied by cytopathic changes. Among probable protective factors (mechanisms) interferon (IFN) was detected in L-41 culture and defective interfering particles in either cell culture. Their role in the establishment and maintenance of chronic infection was not confirmed, however.
D000818:Animals; D002478:Cells, Cultured; D002999:Clone Cells; D003370:Coturnix; D004279:DNA, Viral / Q000032:analysis; D003673:Defective Viruses / Q000254:growth & development; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D006801:Humans; D007370:Interferon Type I / Q000502:physiology; D009109:Mumps virus / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D014762:Viral Interference; D014776:Virus Cultivation
D004279:DNA, Viral; D007370:Interferon Type I