title: [Characteristics of fenazepam excretion in rats and mice].
abstract: Study of excretion of the tranquilizer phenazepam [7-bromo-1,3-dihydro-5-(2'-chlorophenyl)-2H-1,4-benzodiazepine-2-one] and its pharmacologically active metabolite 3-hydroxyphenazepam with urine and feces of rats and mice has shown that the drug is excreted unchanged in extremely negligible amounts. During 5 days, 11.4% of phenazepam with reference to the dose administered is excreted with mouse urine. In rats, this metabolite is detectable in the urine only after phenazepam administration in a dose of 100 mg/kg.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000652:urine*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000652:urine*; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D006207:Half-Life; D007700:Kinetics; D008297:Male; D051379:Mice; D051381:Rats; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; C038294:3-hydroxyphenazepam
vernacular_title: Osobennosti ékskretsii fenazepama u krys i mysheĭ.