GABA synthesis in isolated vestibulary tissue of chick inner ear.
This study was undertaken to assess the possible participation of GABA in neurotransmission in the inner ear of higher vertebrates utilizing isolated chick vestibulary cristae as a model. GABA synthesis was investigated as a suitable criterion for postulating this amino acid as a putative neurotransmitter. Enzyme-mediated GABA synthesis was demonstrated implying a possible neurotransmitter role of this amino acid in the chick vestibule.
D000818:Animals; D002645:Chickens; D005968:Glutamate Decarboxylase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D005973:Glutamine / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D014722:Vestibule, Labyrinth / Q000294:innervation / Q000378:metabolism* / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D005971:Glutamates; D005973:Glutamine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase