Contractions in bronchial musculature of rabbit and man in response to various drugs.
1. The contractile behaviour of rabbit and man bronchial musculature has been tested in response to some commonly used substrates for cholinesterase, histamine and adrenaline by the kymograph technique. 2. The sensitivity of the smooth bronchial musculature from both rabbit and man was found to be highest for acetylcholine and acetyl-beta-methylcholine (6.3 X 10(-8) M) and lowest for butyrylcholine (6.3 X 10(-6) M). 3. The smooth bronchial musculature of man was slightly more sensitive to histamine and adrenaline than that of the rabbit. 4. The results indicate that the contractile behaviour in the smooth bronchial musculature of rabbit and man is remarkably similar.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001980:Bronchi / Q000502:physiology*; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000502:physiology*; D011817:Rabbits
D008688:Methacholine Compounds; D016210:Methacholine Chloride; C017100:butyrylcholine; D006632:Histamine; D002794:Choline; D000109:Acetylcholine; D004837:Epinephrine