Profound suppression of kindled seizures by cysteamine: possible role of somatostatin to kindled seizures.
Recently we reported significant increase in immunoreactive somatostatin content in various brain regions of amygdaloid-kindled rats. We report here that acute intraperitoneal administration of cysteamine, an agent reported to deplete brain and gastrointestinal immunoreactive somatostatin content in kindled rats, led to profound suppression of kindled seizures. Purified anti-somatostatin antibody injected intracerebroventricularly also blocked the kindled seizures. The results show that endogenous immunoreactive somatostatin has a role in the development of seizures in amygdaloid kindled rats.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D003543:Cysteamine / Q000494:pharmacology*; D004558:Electric Stimulation; D007696:Kindling, Neurologic / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*; D013004:Somatostatin / Q000502:physiology*
D013004:Somatostatin; D003543:Cysteamine