title: Improvement in aerobic and hemodynamic responses to exercise following aorta-coronary bypass grafting.
abstract: Preoperative and postoperative hemodynamic studies were performed during exercise in 70 patients having aorta-coronary bypass grafting for the treatment of angina. There was significant symptomatic improvement with 88% of patients free of angina postoperatively. In patients with complete revascularization there was a marked improvement during exercise in maximal oxygen consumption, cardiac index, and maximal pressure-rate product. In addition, there was a fall in pulmonary arterial pressure postoperatively. In contrast, patients with incomplete revascularization showed a small but insignificant rise in maximal oxygen consumption and cardiac index. The major reason for the increase in cardiac index was a marked increase in heart rate rather than a change in stroke index. In patients with complete revascularization there was a significant increase in stroke work index at maximal exercise.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000787:Angina Pectoris / Q000503:physiopathology / Q000601:surgery*; D001794:Blood Pressure; D001026:Coronary Artery Bypass; D005080:Exercise Test; D006339:Heart Rate; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D010101:Oxygen Consumption; D011651:Pulmonary Artery / Q000503:physiopathology; D012146:Rest; D013318:Stroke Volume
chemical_list: D000319:Adrenergic beta-Antagonists