Karabemycin, a new antimetabolite of glutamine produced by a strain of streptomycete.
Karabemycin, a new peptide antibiotic, was isolated from the culture filtrate of Streptomyces sp. AM-6424, a soil isolate. The molecular formula of the antibiotic was determined as C15H24N4O6 on the basis of elemental analysis, FD-mass spectrum and 1H and 13C NMR. Acid hydrolysate of karabemycin contains one mol each of valine, alanine and an unknown amino acid. The antibiotic is active against Gram-positive and -negative bacteria on a synthetic medium. The inhibitory activity is reversed by L-glutamine and L-glutamic acid.
D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001419:Bacteria / Q000187:drug effects; D003470:Culture Media; D005285:Fermentation; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D005973:Glutamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D010455:Peptides / Q000302:isolation & purification / Q000633:toxicity; D013302:Streptomyces / Q000254:growth & development* / Q000648:ultrastructure
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D003470:Culture Media; D005971:Glutamates; D010455:Peptides; D005973:Glutamine; D018698:Glutamic Acid; C039619:karabemycin