Metabolic activation of chemical carcinogens by kidney from rats and mice of various ages.
1. The ability of homogenates from kidney tissue of 4- to 26-month-old male Fischer F344 rats, 6- to 30-month-old male Sprague-Dawley rats, and 5- to 30-month-old male C57 BL/6J mice to metabolically activate the chemical procarcinogens 2-aminofluorene and aflatoxin B1 to mutagens was measured using the Ames Salmonella/microsome test. 2. The conversion of 2-aminofluorene to mutagenic compounds by kidney homogenates from Fischer F344 and Sprague-Dawley rats and C57 BL/6J mice decreased 35-50% with increasing age. 3. An age-related decrease (50-65%) in the ability of kidney homogenates from Fischer F344 rats and C57 BL/6J mice to convert aflatoxin B1 to mutagenic compounds was also observed.
D000375:Aging; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013347:Subcellular Fractions / Q000378:metabolism
D002273:Carcinogens