title: A cupric ion-copper bioaccumulation relationship in coho salmon exposed to copper-containing treated sewage.
abstract: Exposure of coho salmon for 25 days to dilutions of sewage treatment plant effluent with river water containing added Cu (either 35 or 70 micrograms total Cu 1(-1) and an array of Cu2+ concentrations resulted in accumulations of Cu in gill and liver tissues that (a) correlated positively with the Cu2+ contents of the solutions; (b) reached a plateau coincident with onset of mortalities; and (c) correlated positively between these two tissues. Increases in hematocrit percentage and plasma albumin levels occurred in response to 7 micrograms Cu2+ 1(-1), indicating hemoconcentration. Treatment of blood in vitro under similar conditions resulted in association of Cu with the plasma rather than with the erythrocyte fraction.
mesh_terms: D000818:Animals; D003300:Copper / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005880:Gills / Q000378:metabolism; D006400:Hematocrit; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012474:Salmon / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism; D012722:Sewage / Q000032:analysis*; D013054:Spectrophotometry, Atomic; D013696:Temperature; D014873:Water Pollutants / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D011506:Proteins; D012709:Serum Albumin; D012722:Sewage; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D003300:Copper