The spectrum of actions of thyrotropin-releasing hormone on the CNS: a polygraphic study on rabbits.
The effects of i.c.v. administered thyrotropin-releasing hormone (TRH) on EEG, rectal temperature and behaviour were studied on rabbits in basal conditions and after different pretreatments. The effects of TRH on the EEG and behaviour do not seem to involve serotoninergic, catecholaminergic and cholinergic systems. A possible involvement of the GABAergic system is hypothesized.
D000818:Animals; D001143:Arousal / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D004569:Electroencephalography; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007276:Injections, Intraventricular; D018377:Neurotransmitter Agents / Q000502:physiology; D011817:Rabbits; D013239:Stereotyped Behavior / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D018377:Neurotransmitter Agents; D013973:Thyrotropin-Releasing Hormone