[In vitro studies on the adsorption of various resins of the Wofatit type for drugs].
The capacities of the resins Wofatit Y 29, Y 55 and Y 56 (VEB Chemiekombinat Bitterfeld) to adsorb various medicaments were compared with that of the resin XAD-4. Methaquelone, diazepam, krotylbarbital, promazine phosphate and ethyloxamine were used as test substances. The resin Y 56 proved to have an adsorption capacity similar to that of XAD-4 (e.g. maximum saturation for methaquelone 98%, half-maximum saturation at 7 minutes). In further tests on various batches of this resin the best results were given by the resin Y 56/7. Adsorption was quite clearly shown to be dependent on concentration. At a blood-flow of 100 ml/min clearance values of 34.5 ml/min for krotylbarbitol and 22.1 ml/min for methaquelone were calculated. According to these findings the resin Y 56/7 is suitable for further testing in a haemoperfusion system with a view to clinical use.
D001463:Barbiturates / Q000031:analogs & derivatives / Q000097:blood; D003975:Diazepam / Q000097:blood; D006464:Hemoperfusion; D006801:Humans; D008702:Methaqualone / Q000097:blood; D011041:Poisoning / Q000097:blood / Q000628:therapy*; D011395:Promazine / Q000097:blood; D012117:Resins, Synthetic
D001463:Barbiturates; D012117:Resins, Synthetic; D008702:Methaqualone; D011395:Promazine; D003975:Diazepam; C000517:crotarbital
In vitro-Untersuchungen zur Adsorption verschiedener Harze vom Typ Wofatit für Arzneimittel.