Early detection of multiple gestations following hMG-hCG therapy by ultrasonography and midluteal phase progesterone determinations.
Multiple gestations after human menopausal gonadotropin (hMG)-human chorionic gonadotropin (hCG) therapy were detected within 7 gestational weeks (GW) by ultrasound examinations and also by "midluteal phase" (MLP) progesterone (P) concentrations. The mean MLP-P level in nonconception cycles following hMG-hCG therapy was 25.1 +/- 2.1 ng/ml. In the pregnancies following hMG-hCG therapy, MLP-P levels were 32 ng/ml, 37 ng/ml, and 56 ng/ml. These values were associated with a singleton, twin, and triplet pregnancies, respectively. Ultrasonography revealed the number of gestational sacs within 7 GW in each instance. We suggest that assay of MLP-P is useful in women receiving regimens for induction of ovulation. Efforts may as well be made to ascertain multiple conceptions by ultrasound examinations in patients whose MLP-P levels are far above the mean MLP-P level in hMG-hCG-induced cycles.
D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D019411:Clinical Laboratory Techniques; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D008596:Menotropins / Q000627:therapeutic use*; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis; D011374:Progesterone / Q000097:blood*; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D011374:Progesterone; D008596:Menotropins