The anti-inflammatory action of flurbiprofen suppositories in paediatric urology in comparison with co-trimoxazole.
Fifty male children, aged between 3 and 10 years, were treated for a 12-day period with either trimethoprim (80-160 mg) plus sulphamethoxazole (400-800 mg) daily (co-trimoxazole) or 50-125 mg/day flurbiprofen rectally. The patients had been treated surgically for criptorchidism. Flurbiprofen showed good effectivity in controlling post-operative inflammation in urology. It is concluded that antimicrobial agents such as cotrimoxazole, because of their potential risks of damage at the cell's level, should be used only in presence of a bacterial infection.
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000601:surgery; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D004487:Edema / Q000517:prevention & control; D005480:Flurbiprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011422:Propionates / Q000627:therapeutic use*; D011897:Random Allocation; D012611:Scrotum; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D013488:Suppositories; D013810:Therapeutic Equivalency; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D011422:Propionates; D013488:Suppositories; D005480:Flurbiprofen; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole