Hormonal treatment of cryptorchidism.
60 cryptorchid boys (39 unilateral and 21 bilateral) aged between 10 months and 14 years were treated by conservative methods. All boys received an initial therapy of 200 micrograms GnRH nasal spray (decapeptide) in each nostril three times daily for 4 weeks. Those who did not respond favorably to the GnRH treatment immediately received a follow-up therapy with 1,500 IU or boys over 7 years 2,000 IU of HCG per week for a total of 3 weeks. Immediately after completion of this therapy, the success rate was 80% (65/81 testes descended). 6 months afterwards 6 of the 48 testes suffered a relapse. Thus, 73% of the testicles were still descended 6 months after completion of therapy.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D003456:Cryptorchidism / Q000188:drug therapy* / Q000473:pathology; D004822:Epididymis / Q000473:pathology; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D013093:Spermatogonia / Q000473:pathology; D013737:Testis / Q000473:pathology
D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone