Susceptibility of Plasmodium falciparum to pyrimethamine and sulfadoxine/pyrimethamine in Kisumu, Kenya.
Field studies were conducted in Kisumu, Kenya, to assess the susceptibility of local strains of Plasmodium falciparum to pyrimethamine alone (by a standard 7-day in-vivo test and a 48 h in-vitro field test) and to sulfadoxine-pyrimethamine (by a 7-day in-vivo test). Both in-vivo (10/11) and in-vitro (19/21) tests demonstrated that pyrimethamine resistance was very common. Parasite susceptibility to sulfadoxine-pyrimethamine was uniformly greater when 24 isolates were tested in vivo, thus indicating that this drug combination remains valuable despite the high frequency of resistance to pyrimethamine alone.
D002648:Child; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007630:Kenya; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000008:administration & dosage / Q000494:pharmacology*; D013413:Sulfadoxine / Q000008:administration & dosage / Q000494:pharmacology*; D013424:Sulfanilamides / Q000494:pharmacology*
D013424:Sulfanilamides; D013413:Sulfadoxine; D011739:Pyrimethamine