title: [Calcification of the arterial wall in the aging process. Electron microscopic and biochemical studies of a model of vitamin D3 overdose].
abstract: The following mechanisms for inactivating excessive Ca++ are found in the vessel wall (e.g. in old age, arteriosclerosis, hypertension, or overdosage with Vitamin D3): 1. The production of Matrix Vesicles, which reduce biologically active extracellular Ca++ by precipitating it during the initial stage of calcification. 2. An increase in the number of muscle cells changed from the "k" to the "m" form. These also possess a mechanism for reducing the intracellular Ca++ level. If in spite of these mechanisms the extracellular Ca++ concentration remains raised, this can result in calcification of the interzellular substance, particularly the elastic material.
mesh_terms: D000368:Aged; D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology; D002114:Calcinosis / Q000139:chemically induced / Q000473:pathology*; D002118:Calcium / Q000378:metabolism*; D002762:Cholecalciferol / Q000009:adverse effects*; D003327:Coronary Disease / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D004547:Elastic Tissue / Q000473:pathology; D006801:Humans; D008055:Lipids / Q000097:blood; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D012306:Risk
chemical_list: D008055:Lipids; D002762:Cholecalciferol; D002118:Calcium
vernacular_title: Kalzifizierung der Arterienwand als Alternsprozess. Elektronenmikroskopische und biochemische Untersuchungen am Modell der Vitamin-D3-Uberdosierung.