Autoimmune thrombocytopenia acquired from an allogeneic bone-marrow graft.
Severe thrombocytopenia developed after an allogeneic bone-marrow graft in a 40-year-old woman in first remission from acute myeloblastic leukaemia. The thrombocytopenia had an autoimmune basis and was acquired from the bone-marrow donor who had an identical platelet autoantibody. The patient responded to high-dose intravenous IgG, and she has a normal platelet count 10 months after the graft. This study suggests that the immune defect in autoimmune thrombocytopenia can be transferred in cells capable of proliferating in a bone-marrow graft.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001792:Blood Platelets / Q000276:immunology*; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage; D007075:Immunoglobulin M / Q000032:analysis / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D011183:Postoperative Complications / Q000097:blood; D013921:Thrombocytopenia / Q000209:etiology / Q000276:immunology* / Q000628:therapy
D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M