Regulation of rat renal (Na+ + K+)-adenosine triphosphatase activity by triiodothyronine and corticosterone.
The present study concerns the effects of corticosterone and T3 on renal cortical and outer medullary NaK-ATPase activities in the rat. The results show that corticosterone increases cortical and outer medullary NaK-ATPase activities when administered as either a single or multiple doses. Corticosterone and T3 are known to enhance NaK-ATPase activity. We investigate the possibility of interaction between the effects of corticosterone and T3 on renal NaK-ATPase activity. Our studies indicate that corticosterone and T3 regulate renal cortical NaK-ATPase activity via parallel independent pathways, and that corticosterone appears to regulate medullary NaK-ATPase activity without participation by thyroid hormone.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D003345:Corticosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D003345:Corticosterone