[Combined action of caffeine and sydnocarb].
Combined application of two stimulants caffeine and sydnocarb (a sydnonimine derivative) was studied in rabbits, rats and mice using the method of summation of impulses in the central nervous system, the method of conditioned avoidance response, forced swimming and hexobarbital sleep in order to find out the changes in their main and side effects. It was established that the main stimulant effect of the drug combination given in optimal doses appeared to be additive, while side effects on the ECG and blood pressure remained unchanged.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002110:Caffeine / Q000008:administration & dosage* / Q000633:toxicity; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000633:toxicity; D003214:Conditioning, Classical / Q000187:drug effects; D004357:Drug Synergism; D006591:Hexobarbital / Q000037:antagonists & inhibitors; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010069:Oxadiazoles / Q000008:administration & dosage*; D011817:Rabbits; D051381:Rats; D013558:Sydnones / Q000008:administration & dosage* / Q000633:toxicity
D000697:Central Nervous System Stimulants; D010069:Oxadiazoles; D013558:Sydnones; D002110:Caffeine; D006591:Hexobarbital; C009257:sidnocarb
Kombinirovannoe deĭstvie kofeina i sidnokarba.