Investigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors.
Investigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors. Groups of rats were treated orally for four weeks with either dibenzepin, lithiumcarbonate, or dibenzepine + lithium carbonate. Serotonin2 receptors were labelled with the new selective ligand [3H]mesulergine. Chronic treatment with dibenzepin caused down-regulation of serotonin2 receptors in the frontal cortex. Chronic treatment with lithiumcarbonate alone did not change the specific [3H]mesulergine binding. Given simultaneously with dibenzepin lithium did not prevent the down-regulation of serotonin2 receptors seen after dibenzepin alone.
D000818:Animals; D003984:Dibenzazepines / Q000494:pharmacology*; D004873:Ergolines; D005625:Frontal Lobe / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D013997:Time Factors
D003984:Dibenzazepines; D004873:Ergolines; D011985:Receptors, Serotonin; D008094:Lithium; C031649:mesulergine