Isolation of human T-lymphotropic retrovirus (LAV) from Zairian married couple, one with AIDS, one with prodromes.
A Zairian married couple had been living in France since 1981. The man had acquired immunodeficiency syndrome (AIDS) and his wife had prodromes of the disorder. Infection with a human T-lymphotropic retrovirus (lymphadenopathy-associated virus) was demonstrated in both by isolation of the virus from their cultured lymphocytes and the detection of specific antibodies in serum samples. Since this virus has been isolated from patients in other AIDS risk categories, the finding of the virus in AIDS patients from the African group adds further support to the hypothesis that this human retrovirus is the AIDS aetiological agent.
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology / Q000235:genetics / Q000276:immunology / Q000382:microbiology*; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D017977:Deltaretrovirus / Q000276:immunology; D015023:Democratic Republic of the Congo / Q000208:ethnology; D005260:Female; D005602:France; D006801:Humans; D006967:Hypersensitivity; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000382:microbiology*; D008297:Male; D012190:Retroviridae / Q000276:immunology / Q000302:isolation & purification*; D013601:T-Lymphocytes / Q000145:classification
D000914:Antibodies, Viral