A single dose of benzodiazepine hypnotics alters the sleep EEG in the subsequent drug-free night.
All-night spectral analysis of the sleep EEG was used to study the effect and after-effect of a single bedtime dose of flunitrazepam (2 mg), flurazepam (30 mg) or triazolam (0.5 mg) in healthy young males. In the night of drug treatment all 3 hypnotics reduced the EEG slow waves and enhanced the activity in the frequency range of sleep spindles. In the subsequent drug-free night, the latter changes were no longer present after triazolam, whereas the reduction of slow wave activity persisted after all compounds.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D004569:Electroencephalography; D005445:Flunitrazepam / Q000494:pharmacology; D006801:Humans; D008297:Male; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors; D014229:Triazolam / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D014229:Triazolam; D005445:Flunitrazepam