Influence of cisternal pressure on passage of neuropeptides from the cerebrospinal fluid into the peripheral circulation.
Passage of neuropeptides from the cerebrospinal fluid to circulation depends upon cisternal pressure. When cisternal collecting pressure was kept at -20 cm, plasma levels of gastrin-17 and somatostatin-14 remained at basal values despite perfusion of high doses of the peptides into the cerebro-ventricular system. Progressive reduction of this pressure above -15 cm results in a progressive rise of the peripheral concentration of the peptides. Discrimination between central and peripheral action of centrally administered neuropeptides is, therefore, possible.
D000818:Animals; D005755:Gastrins / Q000097:blood / Q000134:cerebrospinal fluid*; D007427:Intracranial Pressure; D011817:Rabbits; D013004:Somatostatin / Q000097:blood / Q000134:cerebrospinal fluid*
D005755:Gastrins; D013004:Somatostatin; C013550:gastrin 17