Effect of adding albumin to solutions of somatostatin on inhibiting pentagastrin-stimulated acid secretion in dogs.
In five conscious dogs with chronic gastric fistulas we studied the effect of somatostatin solutions on pentagastrin-stimulated acid secretion. Somatostatin was dissolved in 0.154 M NaCl alone or in the same amount of saline to which dog albumin had been added to give a 0.5% solution. Somatostatin produced a dose-dependent inhibition of pentagastrin-stimulated gastric secretion. However, the inhibition was significantly less when somatostatin was dissolved in saline as compared to saline plus albumin. This study suggests that albumin should be added to somatostatin solutions to preserve biological activity, and it confirms previous reports indicating that, without albumin, basic peptides have a tendency to stick to infusion systems.
D000418:Albumins / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000502:physiology; D010418:Pentagastrin / Q000494:pharmacology; D012996:Solutions; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*
D000418:Albumins; D004338:Drug Combinations; D012996:Solutions; D013004:Somatostatin; D010418:Pentagastrin