Effect of alinidine (St 567) on sympathetic and vagal activities.
A depressor effect on spontaneous preganglionic sympathetic discharge rate could be shown in anaesthetized, debuffered cats after i.v.-injection of 2.5 mg/kg alinidine. This effect developed gradually and did not parallel the marked bradycardia which was of prompt onset. In anaesthetized dogs with beta-adrenoceptors blocked, alinidine (2.5 mg/kg i.v. or 0.5 mg/kg intracisternally) proved to be without effect on vagally mediated reflex bradycardia. This reaction pattern (inhibition of sympathetic discharges, no effect on vagal baroreflex activity) differentiates alinidine from clonidine-like substances, which are known to decrease sympathetic tone and to increase vagally mediated reflex bradycardia.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014630:Vagus Nerve / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; C022192:alinidine; D003000:Clonidine