Repeated electroconvulsive shock has no specific anxiolytic effect but reduces social interaction and exploration in rats.
Administration of repeated electroconvulsive shock (ECS) to rats did not result in a specific anxiolytic profile in the social interaction test, but did significantly reduce several spontaneous behaviours: social interaction, locomotor activity, exploratory head-dipping and rearing. None of these behavioural changes was reversed by the administration of pentylenetetrazol prior to each seizure, a treatment that abolishes ECS-induced changes in GABA and 5-HT in the brain.
D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents; D001522:Behavior, Animal / Q000187:drug effects*; D004597:Electroshock; D007398:Interpersonal Relations; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D014151:Anti-Anxiety Agents; D010433:Pentylenetetrazole