Separate origins for the dynorphin and enkephalin immunoreactive fibers in the inferior mesenteric ganglion of the guinea pig.
By different denervation procedures the origin of dynorphin-(1-17) and enkephalin immunoreactive fibers in the guinea pig inferior mesenteric ganglion was investigated. It was found that the dynorphin-(1-17)-positive fibers reached the ganglion predominantly via the colonic nerves and to a lesser extent via the hypogastric and intermesenteric nerves whereas the enkephalin-positive fibers reached the ganglion via the lumbar splanchnic nerves. These findings show that the dynorphin-(1-17) and enkephalin systems are separate in this ganglion.
D000818:Animals; D004399:Dynorphins; D004723:Endorphins / Q000276:immunology*; D004745:Enkephalins / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D005728:Ganglia, Sympathetic / Q000033:anatomy & histology* / Q000276:immunology; D006168:Guinea Pigs; D008297:Male; D009412:Nerve Fibers / Q000033:anatomy & histology* / Q000276:immunology
D004723:Endorphins; D004745:Enkephalins; D004399:Dynorphins