Lorazepam in children. A double-blind trial comparing lorazepam, diazepam, trimeprazine and placebo.
One hundred patients aged 5-13 yr were randomly allocated to four groups in a double-blind study of premedication. Drugs studied were lorazepam, diazepam and trimeprazine. A placebo group was included. All the drugs appeared satisfactory as premedicants. Lorazepam induced the most sedation immediately after surgery, but by 4 h lorazepam and diazepam appeared similar. Lorazepam produced better amnesia than the other drugs. There were no untoward side-effects and no cardiorespiratory depression in any group. Lorazepam appears a suitable premedicant for children.
D000293:Adolescent; D000647:Amnesia; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000494:pharmacology; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology; D011229:Preanesthetic Medication; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects; D013997:Time Factors; D014291:Trimeprazine / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D014291:Trimeprazine; D008140:Lorazepam; D003975:Diazepam