[The effect of stress factors on the ultrastructure of the myocardium and creatinine kinase activity in the blood of rats premedicated with metipranolol].
After a four-hour long immobilization stress, heart muscle cells, viewed in the electron microscope, showed a fine swelling of the endothelium of the capillaries, a fine dilatation of the sarcoplasmatic reticulum, but formation of fat drops was rare. Following sudden withdrawal of the application of metipronolol stress caused more serious damage to the ultrastructure of the heart muscle cells than if the animals were subjected to stress alone. The authors observed large accumulations of fat droplets, dilatation of the sarcoplasmatic reticulum, swollen mitochondria and spindle shaped dehiscences in the intercalated discs. Immobilization stress led to increased activity of creatine kinase in the serum, while previous application of metipranolol caused its decrease.
D000818:Animals; D003402:Creatine Kinase / Q000097:blood*; D006321:Heart / Q000187:drug effects; D007103:Immobilization; D008297:Male; D014290:Metipranolol / Q000494:pharmacology*; D009206:Myocardium / Q000648:ultrastructure*; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000201:enzymology / Q000473:pathology*
D011412:Propanolamines; D003402:Creatine Kinase; D014290:Metipranolol
Vplyv stresových faktorov na ultraśtruktúru myokardu a aktivitu sérovej kreatinkinázy u potkanov premedikovaných metipranololom.