Influenza A prophylaxis with amantadine in a boarding school.
In a boarding school for boys, where routine influenza vaccination is carried out annually, 267 boys were given amantadine (100 mg daily) and 269 received no specific treatment during an influenza A (H1N1) outbreak. 3 boys receiving amantadine and 29 boys receiving no medication had laboratory-proven influenza A. There are circumstances when the prophylactic use of amantadine may be justified for the control of influenza A outbreaks in boarding schools and other institutions where high attack-rates are experienced.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000547:Amantadine / Q000008:administration & dosage / Q000627:therapeutic use*; D004196:Disease Outbreaks / Q000517:prevention & control*; D006801:Humans; D009980:Influenza A virus / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000517:prevention & control* / Q000635:transmission; D008297:Male; D012112:Residential Facilities; D006113:United Kingdom
D007252:Influenza Vaccines; D000547:Amantadine