Bordetella pertussis-induced impairment of relaxation of rat trachea to isoprenaline and histamine and its reversal with hydrocortisone.
Bordetella pertussis vaccination of rats resulted in impairment of relaxation to isoprenaline and histamine of partially contracted tracheal smooth muscle. The concentration range of carbachol (10(-6) to 5 x 10(-6) M) required for contraction (ED50) did not differ from the control group. Pretreatment of vaccinated animals with hydrocortisone was found to reverse the inhibition of spasmolytic activity.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006635:Histamine H2 Antagonists; D006854:Hydrocortisone / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D010567:Pertussis Vaccine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014132:Trachea / Q000187:drug effects*
D006635:Histamine H2 Antagonists; D010567:Pertussis Vaccine; D006632:Histamine; D002217:Carbachol; D007545:Isoproterenol; D006854:Hydrocortisone