title: Hypnotic efficacy and safety of midazolam and oxazepam in hospitalized female patients.
abstract: This double-blind study in 60 hospitalized female patients comparing midazolam 15 mg, oxazepam 15 mg and placebo, demonstrated an inter-group difference in favour of midazolam with regard to efficacy. The sleep parameters of onset latency and duration were improved by midazolam. All three compounds were very well tolerated and no withdrawal symptoms were observed. Midazolam, in an oral dose of 15 mg, can thus be regarded as an effective, well-tolerated agent for the treatment of sleep disorders.
mesh_terms: D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004325:Dreams; D005260:Female; D006760:Hospitalization; D006801:Humans; D008874:Midazolam; D008875:Middle Aged; D010076:Oxazepam / Q000009:adverse effects / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000188:drug therapy*
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D010076:Oxazepam; D008874:Midazolam