title: Altered neuropeptide concentrations in cerebrospinal fluid of psychiatric patients.
abstract: Immunoreactive somatostatin, bombesin, and cholecystokinin were measured in cerebrospinal fluid of normal subjects and patients with anorexia nervosa, depression, mania, and schizophrenia. Somatostatin-like immunoreactivity was decreased in anorexic and depressed patients. Bombesin-like immunoreactivity tended to be decreased in schizophrenics. Cholecystokinin-like immunoreactivity did not differ between groups. These data suggest a possible function for neuropeptides in regulation of human behavior.
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000134:cerebrospinal fluid; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid; D001839:Bombesin / Q000134:cerebrospinal fluid*; D002766:Cholecystokinin / Q000134:cerebrospinal fluid*; D003866:Depressive Disorder / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000134:cerebrospinal fluid*; D010455:Peptides / Q000134:cerebrospinal fluid*; D012559:Schizophrenia / Q000134:cerebrospinal fluid; D013004:Somatostatin / Q000134:cerebrospinal fluid*
chemical_list: D010455:Peptides; D013004:Somatostatin; D002766:Cholecystokinin; D001839:Bombesin