Somatostatin-induced apnea: interaction with hypoxia and hypercapnea in the rat.
The effects of hypoxia and hypercapnea in the production of somatostatin (SRIF)-induced apnea were studied during rebreathing experiments. Hypoxia and hypercapnea resulted in a shortening of the latency of SRIF-induced apnea. In order to exclude the effect of stimulation of central chemoreceptors by mock-CSF solution, control experiments using mock-CSF in combination with hypoxia and hypercapnea were done. No apnea could be produced by the mock-CSF in combination with hypoxia and hypercapnea. The shortening of apneic latency from 480 +/- 8 s (S.E.M.) to 148 +/- 30 s with the addition of a chemostimulus (hypoxia and hypercapnea) in SRIF-induced respiratory depression demonstrates that chemostimulation interacts with the centrally originating apnea to enhance its apneic response.
D000818:Animals; D001049:Apnea / Q000139:chemically induced* / Q000150:complications; D001931:Brain Mapping; D002628:Chemoreceptor Cells / Q000502:physiology; D006935:Hypercapnia / Q000150:complications*; D000860:Hypoxia / Q000150:complications*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin