Effect of alpha-difluoromethylornithine, an irreversible ornithine decarboxylase inhibitor, on formation of GGTase-positive foci.
The importance of the induction of ornithine decarboxylase to the development of GGTase foci is examined in the classic initiation-promotion assay. This was accomplished by examining the complete foci system in the presence and absence of alpha-DFMO, an irreversible inhibitor of ornithine decarboxylase, at concentrations capable of inhibiting both phenobarbital stimulated and control levels of the enzyme. Although the hepatic enzyme was inhibited by the alpha-DFMO, there was no decrease in the progression of formation of the GGTase foci.
D000818:Animals; D000518:Eflornithine; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D008297:Male; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D065108:Ornithine Decarboxylase Inhibitors; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000032:analysis*
D065108:Ornithine Decarboxylase Inhibitors; D009952:Ornithine; D005723:gamma-Glutamyltransferase; D010634:Phenobarbital; D000518:Eflornithine