Vasoconstrictory effects of adrenalin on the perfused head of the eel (Anguilla anguilla L.).
Adrenalin (5.0 X 10(-5) M) increases gill vascular resistance up to 23.2 +/- 6.8% in the isolated and perfused head of the european eel (Anguilla anguilla L.). This vasoactive response is nearly abolished by the alpha-adrenergic blocking agent phentolamine mesylate (5.0 X 10(-5) M), while it is increased by the beta-blocker propranolol (5.0 X 10(-4) M). From these results it may be inferred that, in our experimental conditions, the major response to the catecholamine is a vasoconstriction mediated via alpha-adrenoceptors.
D000818:Animals; D004524:Eels / Q000502:physiology*; D004837:Epinephrine / Q000494:pharmacology*; D005880:Gills / Q000098:blood supply; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D011433:Propranolol; D004837:Epinephrine; D010646:Phentolamine