title: Metabolism of parathion and brain cholinesterase inhibition in aroclor 1254-treated and untreated Caspian terrapin (Mauremys caspica rivulata, Emydidae, Chelonia) in comparison with two species of wild birds.
abstract: The mean level of PCB residues in the liver of the Caspian turtle collected in nature was 23 ppm, or approximately 20-fold greater than that detected in the two bird species tested. Treatment of the turtles with aroclor 1254 resulted in a 30-fold increase in the level of PCB residues in the liver but did not cause any increase in the content of cytochrome P-450 and the desulfurase activity of this hemoprotein. The Ki value for acetylcholinesterase inhibition by paraoxon in brain homogenate of the Caspain terrapin was 3 and 2 orders of magnitude higher than that found in the African bulbul and the barn owl, respectively.
mesh_terms: D000818:Animals; D001140:Aroclors / Q000494:pharmacology*; D001717:Birds / Q000378:metabolism*; D001921:Brain / Q000201:enzymology*; D020111:Chlorodiphenyl (54% Chlorine); D002800:Cholinesterase Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D008099:Liver / Q000378:metabolism; D008297:Male; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010261:Paraoxon / Q000378:metabolism; D010278:Parathion / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D013045:Species Specificity; D014426:Turtles / Q000378:metabolism*
chemical_list: D001140:Aroclors; D002800:Cholinesterase Inhibitors; D003573:Cytochrome b Group; D020111:Chlorodiphenyl (54% Chlorine); D010278:Parathion; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D009251:NADPH-Ferrihemoprotein Reductase; D010261:Paraoxon