[Participation of GABA and other mediators in regulating the convulsive threshold].
The participation of GABA and some other transmitter systems in the regulation of the convulsive seizure threshold was studied using pharmacological tools. The convulsion were provoked by intravenous infusion of the GABAergic antagonists picrotoxin and bicuculline and, in some cases, of pentylenetetrazole and strychnine. The GABAergic transmitter mechanisms were established to play a major role in the regulation of the convulsive seizure threshold. Of some importance is also the participation of benzodiazepine receptors, cholinergic, dopaminergic, serotoninergic mechanisms, as well as of cyclic nucleotides. The interactions between the GABAergic and dopaminergic, cholinergic mechanisms, cyclic nucleotides, benzodiazepine receptors may also play a role in the convulsive threshold regulation. The changes in the threshold of convulsive reactions are closely related to the decrease or increase of both central inhibition (pre- or postsynaptic) and excitation.
D000818:Animals; D003292:Convulsants / Q000494:pharmacology; D018756:GABA Antagonists; D051379:Mice; D018377:Neurotransmitter Agents / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D003292:Convulsants; D018756:GABA Antagonists; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid
Uchastie GAMK i drugikh mediatorov v reguliatsii sudorozhnogo poroga.