title: The dopamine receptor in the intermediate lobe of the rat pituitary gland is negatively coupled to adenylate cyclase.
abstract: The potency of a series of drugs to inhibit cyclic AMP accumulation in cells of the intermediate lobe of the rat pituitary gland in culture is typically dopaminergic. Dopaminergic antagonists reverse the inhibition of cyclic AMP levels according to their known pharmacological activity. The present data show that activation of the dopamine receptor in pars intermedia cells leads to inhibition of basal cyclic AMP accumulation and thus suggest that this receptor is negatively coupled to adenylate cyclase.
mesh_terms: D000262:Adenylyl Cyclases / Q000502:physiology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D000242:Cyclic AMP / Q000032:analysis; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology*
chemical_list: D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D009074:Melanocyte-Stimulating Hormones; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D004298:Dopamine