The hemolytic activity of suberitine.
1. The hemolytic activity of suberitine, a neurotoxic protein isolated from Suberites domuncula, has been examined. 2. The toxin has no phospholipase A activity. 3. The hemolytic activity of suberitine does not exhibit the induction period and is completely inhibited by sucrose. 4. A study of the effect of temperature on the rate of hemolysis shows that suberitine has two values of the critical thermal increment. The optimum pH for the hemolytic activity was 6.0. 5. There was a correlation between the hemolytic and toxic activity.
D000818:Animals; D003386:Brachyura; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D008387:Marine Toxins / Q000494:pharmacology* / Q000633:toxicity; D009498:Neurotoxins; D010741:Phospholipases A / Q000032:analysis; D011506:Proteins / Q000494:pharmacology* / Q000633:toxicity; D013696:Temperature
D008387:Marine Toxins; D009498:Neurotoxins; D011506:Proteins; C031284:suberitine protein, Suberites domuncula; D010741:Phospholipases A