Influence of ricinoleic acid on the contractions elicited by PGE2 on the guinea-pig ileum.
The effect of ricinoleic acid on prostaglandin E2 (PGE2)-evoked contractions was studied on guinea-pig isolated ileum. Addition of ricinoleic acid (10 micrograms ml-1) to the organ bath increased the amplitude of the PGE2-evoked responses. Ricinoleic acid (10 micrograms ml-1) also sensitized the guinea-pig isolated ileum to acetylcholine and histamine. The effect of the ricinoleic acid was greatly reduced by indomethacin either in-vivo (10 mg ml-1) or in-vitro (2 micrograms ml-1).
D000818:Animals; D015232:Dinoprostone; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology*; D012277:Ricinoleic Acids / Q000494:pharmacology*
D005231:Fatty Acids, Unsaturated; D011458:Prostaglandins E; D012277:Ricinoleic Acids; C030521:ricinoleic acid; D015232:Dinoprostone; D007213:Indomethacin