The effects of single and repeated doses of maprotiline, oxaprotiline and its enantiomers on foot-shock induced fighting in rats.
Foot-shock induced fighting behavior (SIF) in rats was tested after single and repeated dose-treatment (10 mg/kg IP twice daily for 10 days) of maprotiline, oxaprotiline and of (+)- and (-)-enantiomers of oxaprotiline. Marked facilitation of SIF was observed after repeated but not single administration of all drugs including the NA-uptake inactive (-)-enantiomer of oxaprotiline. No enhancement of SIF was seen after multiple dose-treatment with promethazine, an antihistaminic, or atropine. The mechanism of the facilitation of SIF induced by antidepressants maprotiline and oxaprotiline as well as by its enantiomers is unclear. The clear-cut dissociation of the effect of (+)- and (-)-oxaprotiline on the rate of NA-disappearance, but their similar enhancing effect on SIF challenges the assumption of a primary importance of central NA-system in this behavior. By contrast, the increase in jumping behavior recorded additionally to SIF, seems to be a great extent dependent on NA-uptake inhibiting properties of tested drugs.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D002540:Cerebral Cortex / Q000201:enzymology; D004597:Electroshock; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000031:analogs & derivatives / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D011398:Promethazine / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
D000873:Anthracenes; D008376:Maprotiline; C027299:hydroxymaprotilin; D001285:Atropine; D014446:Tyrosine 3-Monooxygenase; D011398:Promethazine; D009638:Norepinephrine