title: Multidrug resistance.
abstract: Mutations resulting in a complex phenotype of cross-resistance and collateral-sensitivity are frequently observed in mammalian cell lines. A cell surface 170 000 dalton glycoprotein (P-glycoprotein) has been identified to be intimately associated with this multidrug resistance phenotype. We speculate that such mutations also occur in advanced cancers and play a major role in contributing to the non-response to combination chemotherapy. In this context, P-glycoprotein may be a useful molecular marker for diagnostic and therapeutic applications.
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D005260:Female; D005819:Genetic Markers; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D010053:Ovary; D010641:Phenotype
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D005819:Genetic Markers; D006023:Glycoproteins