Dose-response study of somatostatin on meal-stimulated levels of pancreatic polypeptide and insulin in the dog.
A dose-response study of the effect of 0.1-5.0 micrograms kg-1 h-1 somatostatin was performed on food-induced rise of pancreatic polypeptide and insulin in 4 dogs. There was a dose-dependent suppression of the release of pancreatic polypeptide and insulin with an ED50 of approximately 0.65 and 0.8 microgram kg-1 h-1, respectively, during the first 45-min period. In the second 45-min period, high doses of somatostatin failed to suppress insulin concentrations whereas, the serum concentrations of pancreatic polypeptide were reduced by a similar degree as in the first 45 min. The differing effects of somatostatin on food-stimulated serum concentrations of insulin and pancreatic polypeptide indicate that somatostatin does not represent a uniform suppressor of pancreatic hormones.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005502:Food; D007328:Insulin / Q000378:metabolism*; D007329:Insulin Antagonists; D000078790:Insulin Secretion; D010191:Pancreatic Polypeptide / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology*; D013997:Time Factors
D007328:Insulin; D007329:Insulin Antagonists; D013004:Somatostatin; D010191:Pancreatic Polypeptide