title: Induction of 'rage' following microinjections of glutamate into midbrain but not hypothalamus of cats.
abstract: Microinjections of glutamic acid were made into the same midbrain and hypothalamic sites of cats at which 'defensive-rage' behaviour was elicited by electrical stimulation. It was found that : (1) medial hypothalamic and midbrain tegmental glutamate injections were without behavioural effect; (2) midbrain periaqueductal grey injections elicited a 'rage' display. Since glutamate depolarizes cell bodies but not axons, the results suggest that there is a specific population of neurones in the midbrain whose excitation elicits this reaction.
mesh_terms: D000786:Anger / Q000187:drug effects*; D000818:Animals; D001931:Brain Mapping; D002415:Cats; D004558:Electric Stimulation; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D007031:Hypothalamus / Q000187:drug effects*; D008636:Mesencephalon / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D011889:Rage / Q000187:drug effects*
chemical_list: D005971:Glutamates; D018698:Glutamic Acid