Extent of vaginal absorption of sulphated polysaccharide from A-gen 53 in the rabbit.
The vaginal absorption of a sulphated polysaccharide (SAEP), the active substance of A-gen 53+, was studied in rabbits using the 35S-labelled product. After intra-vaginal administration of 35S-SAEP, measurements of 35S in urine, faeces, plasma and tissues of the reticulo-endothelial system indicated that the small proportion of the dose (ca. 5%) absorbed from the vagina was associated mainly with inorganic material (i.e. 35S-sulphate), present as an impurity in the 35S-dose.
D000042:Absorption; D000818:Animals; D003271:Contraceptive Agents, Female / Q000378:metabolism*; D005260:Female; D011134:Polysaccharides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D011817:Rabbits; D013488:Suppositories; D014018:Tissue Distribution; D014621:Vagina / Q000378:metabolism*
D003271:Contraceptive Agents, Female; D011134:Polysaccharides; D013488:Suppositories