Binding of tubocurarine, fazadinium, pancuronium and Org NC 45 to serum proteins in normal man and in patients with cirrhosis.
The protein binding of four non-depolarizing neuromuscular blocking drugs-tubocurarine, fazadinium, pancuronium and Org NC45-was measured, in serum from normal patients and from patients with cirrhosis of the liver, by an ultracentrifugation method. The fraction bound to serum protein in normal patients was 56% for tubocurarine, 51% for fazadinium, 29% for pancuronium and 30% for Org NC 45. In patients with cirrhosis, the protein binding of the four drugs was similar to that obtained in the normal patient.
D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D003473:Neuromuscular Nondepolarizing Agents / Q000097:blood*; D010197:Pancuronium / Q000031:analogs & derivatives / Q000097:blood; D011485:Protein Binding; D011726:Pyridinium Compounds / Q000097:blood; D014403:Tubocurarine / Q000097:blood; D014673:Vecuronium Bromide
D001798:Blood Proteins; D003473:Neuromuscular Nondepolarizing Agents; D011726:Pyridinium Compounds; D014673:Vecuronium Bromide; D010197:Pancuronium; D014403:Tubocurarine