[Effects of krestin and p-aminobenzoic-N-xyloside sodium salt on activities of drug-metabolizing enzymes and glutathione-related enzymes in rat liver].
Effects of krestin (PSK) and p-aminobenzoic-N-xyloside sodium salt (K-247) (both products of Kreha Chemical Co., Japan) on activities of drug-metabolizing enzymes and glutathione (GSH)-related enzymes were investigated in rat liver. When PSK was administered at a dose of 100 mg/kg body weight, ip every day for 7 or 14 days, the action of UDP-glucuronyltransferase (UDP-GT) on o-aminophenol (o-GT) and those of GSH S-transferase (GST) on both 1, 2-dichloro-4-nitrobenzene ( DCNB ) and 1-chloro-2, 4-dinitrobenzene (CDNB) slightly increased together with increased activities of GSH-peroxidase on both H2O2 and cumene hydroperoxide, were as GSH levels were decreased. When PSK or K-247 was administered at 1% in diet for 4 or 8 weeks, o-GT activity and GST activities with both substrates increased on K-247 feeding, while GST activity for CDNB decreased on PSK and K-247 feedings. These changes were statistically significant but very small. The content of P-450 and the activity of gamma-glutamyl transpeptidase changed little in any administration schedules mentioned above.
D010129:4-Aminobenzoic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D062365:Aminobenzoates / Q000494:pharmacology*; D000818:Animals; D004137:Dinitrochlorobenzene / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009578:Nitrobenzenes / Q000378:metabolism; D011509:Proteoglycans / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000378:metabolism; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes; D011509:Proteoglycans; D062366:para-Aminobenzoates; C035660:4-aminobenzoic acid-N-xyloside; C010770:polysaccharide-K; C028328:1,2-dichloro-4-nitrobenzene; D005979:Glutathione Peroxidase; D005723:gamma-Glutamyltransferase; D014453:Glucuronosyltransferase; D005978:Glutathione; D010129:4-Aminobenzoic Acid