[The cells with a transient adrenergic phenotype in the embryonic intestines of rodents are neuronal in nature].
In the gut of Rat and Mouse embryos, a cell population transiently expresses tyrosine hydroxylase (TOH), as well as other adrenergic phenotypic characters, during the initial stages of the formation of the intrinsic innervation. The nature of these cells has been determined by immunohistochemical methods, using anti-neurofilament (NF) protein antibodies. NF first appear at 10.5 days of gestation and are detectable in most TOH-containing cells between 10.5 and 12.5 days of gestation. Consequently, the transient adrenergic gut cells are neurons. In turn, this indicates their neural crest origin. They form a large proportion of the initial cell population of enteric neurons.
D000818:Animals; D005260:Female; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis*; D007422:Intestines / Q000166:cytology / Q000196:embryology* / Q000201:enzymology; D051379:Mice / Q000196:embryology; D009474:Neurons / Q000032:analysis*; D010641:Phenotype; D011247:Pregnancy; D012377:Rodentia / Q000196:embryology*; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*
D007381:Intermediate Filament Proteins; D014446:Tyrosine 3-Monooxygenase
Les cellules à phénotype adrénergique transitoire de l'intestin embryonnaire des rongeurs sont de nature neuronale.