title: A call for caution in the use of aminoglutethimide: negative interactions with dexamethasone and beta blocker treatment.
abstract: Two case reports are described, both breast carcinoma patients with metastatic disease. One of the patients had a dexamethasone dependent brain metastatic condition. The second patient suffered from high blood pressure, which was controlled with beta-blocker drugs. Both patients developed severe complications when treated with aminoglutethimide as a cancer hormonal therapy. The case reports are described and possible drug interaction mechanisms are discussed.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000368:Aged; D000616:Aminoglutethimide / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000188:drug therapy*; D003907:Dexamethasone / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008875:Middle Aged; D011433:Propranolol / Q000009:adverse effects
chemical_list: D000319:Adrenergic beta-Antagonists; D000616:Aminoglutethimide; D003907:Dexamethasone; D011433:Propranolol