Failure of somatostatin to inhibit the stimulatory effect of different compounds on the lower esophageal sphincter of the rat.
In the present paper the tetradecapeptide somatostatin was investigated for its possible inhibitory effect on the lower esophageal sphincter (LES) of the rat. Somatostatin, which is known to inhibit both release of several hormones and also their actions, was found to be ineffective on the isolated rat LES. The hormone did not inhibit basal tone and did not antagonize the stimulatory effect of different peptidic and non-peptidic biological substances. The meaning and the importance of the above observations are discussed.
D000818:Animals; D004347:Drug Interactions; D004943:Esophagogastric Junction / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin