Estradiol is concentrated in tyrosine hydroxylase-containing neurons of the hypothalamus.
Localization of [3H]estradiol in tyrosine hydroxylase-containing neurons of rat brain was shown by a combined technique of autoradiography and immunohistochemistry. [3H]Estradiol was concentrated in the nuclei of tyrosine hydroxylase-containing neurons in the nucleus arcuatus, nucleus periventricularis hypothalami, and the zona incerta. These results suggest that estradiol acts directly on dopamine-producing neurons of the tuberoinfundibular system and incertohypothalamic system.
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000032:analysis / Q000201:enzymology; D002467:Cell Nucleus / Q000032:analysis; D004958:Estradiol / Q000032:analysis*; D005260:Female; D007031:Hypothalamus / Q000032:analysis* / Q000201:enzymology; D009474:Neurons / Q000032:analysis* / Q000201:enzymology; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D004958:Estradiol; D014446:Tyrosine 3-Monooxygenase