[Changes in the synaptosomal membranes in the chronic neurotization of rats].
A study was made of the changes in synaptosomal membranes and in some synaptic processes under the development of experimental neurosis in rats. Neurotic rats demonstrated changes in the protein/lipid correlation and in the interaction of the fluorescent ANS probe and synaptosomal membranes. This can be accounted for by an increase in the membrane water repellency. The activity of Na, K-ATPase remains unchanged. The rate of noradrenaline, serotonin, dopamine and GABA synaptosomal reverse uptake in neurotic rats was found to be increased.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D005456:Fluorescent Dyes / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000032:analysis; D008297:Male; D009497:Neurotic Disorders / Q000503:physiopathology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D013570:Synaptic Membranes / Q000032:analysis / Q000502:physiology*; D013574:Synaptosomes / Q000032:analysis / Q000502:physiology*; D013997:Time Factors
D005456:Fluorescent Dyes; D008055:Lipids; D018377:Neurotransmitter Agents
Izmeneniia sinaptosomal'nykh membran pri khronicheskoĭ nevrotizatsii krys.