Effects of aconitine and veratrine on the isolated perfused heart of the common eel (Anguilla anguilla L.).
The effects of two alkaloids: aconitine and veratrine have been investigated in isolated perfused heart of the common eel (Anguilla anguilla L.). Low concentrations (less than 10(-6)M) of aconitine induced a decrease of the heart rate where high concentrations (greater than 10(-6)M) produced a tachycardia and finally led to a depolarization of cardiac cells. Veratrine induced a decrease of the heart rate depending on the concentration. A cardiac arrest was observed with high concentrations (greater than 10(-4)M). Removal of aconitine or veratrine from perfusion medium did not reverse the effects of high concentrations. The tachycardia and arrhythmias were triggered or enhanced.
D000157:Aconitine / Q000494:pharmacology*; D031841:Aconitum / Q000031:analogs & derivatives*; D000200:Action Potentials / Q000187:drug effects; D000811:Anguilla / Q000502:physiology*; D000818:Animals; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D014702:Veratrine / Q000494:pharmacology*
D007473:Ion Channels; D014702:Veratrine; D000157:Aconitine