Pharmacotherapy of agitational states in psychiatric gerontology: double-blind study: febarbamat-pipamperon.
The effects of febarbamat and pipamperon on agitational and aggressive states of patients with diffuse psycho-organic syndrome were compared in a double-blind study on patients over 60 years of age requiring nursing care. Such disorders, particularly in the field of psychiatric gerontology, represent an increasing problem. The neuroleptic agents hitherto prescribed for such agitational states are not only beset with serious side-effects (predyskinesia, drug-induced Parkinson syndrome, sedentary restlessness, postdyskinesia), but particularly with an unwanted suppression of the patients' reactions. It was therefore of particular interest to find out if febarbamat showed an equally good therapeutic effect on aggressive and agitational states, without causing these side-effects (especially suppression of cognitive performance). This could have a positive effect on social and other therapeutic activities. The test substances were therapeutically comparable in their effect on agitational and aggressive states. On the psychological level, febarbamat showed superiority in the cognitive performance parameters.
D000368:Aged; D000374:Aggression / Q000187:drug effects; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001463:Barbiturates / Q000627:therapeutic use*; D002090:Butyrophenones / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003704:Dementia / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000523:psychology
D014150:Antipsychotic Agents; D001463:Barbiturates; D002090:Butyrophenones; D006993:Hypnotics and Sedatives; C005569:pipamperone; C003087:febarbamate