title: [Clinical experiences with a fibrin-nebacetin-spongy bone seal in the treatment of chronic bone infections and as local prophylaxis of infection in uninfected bones].
abstract: Clinical experiences with Fibrin-Nebacetin-bone marrow combination for the treatment of chronic bone infection and as local prophylaxis by operation of non-infected bone diseases. Since 1979 we have carried out 33 autologous bone graftings in children and used the Fibrin-Nebacetin-bone marrow combination. Nebacetin provides a most effective local antibiotic therapy as supplementary and consecutive treatment are surgical procedures executed in bone infection. The chronic bone infection of 15 children subsided completely. In 18 children with bone transplants no infections was observed and all the patients showed primary healing. The use of fibrin did not disturb the bone reconstruction. After 12 weeks the reconstruction of the bone was almost complete. In two cases only we had to make a reoperation, caused by a recurrent cyst. We could not observe any hepatitis in our patients. The operative technique and advantages of treatment were discussed.
mesh_terms: D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001414:Bacitracin / Q000008:administration & dosage*; D001845:Bone Cysts / Q000601:surgery; D001847:Bone Diseases / Q000601:surgery*; D016025:Bone Transplantation; D002648:Child; D004338:Drug Combinations / Q000008:administration & dosage; D005176:Factor XIII / Q000008:administration & dosage*; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009355:Neomycin / Q000008:administration & dosage*; D010019:Osteomyelitis / Q000601:surgery*; D011292:Premedication; D011542:Pseudarthrosis / Q000601:surgery; D013917:Thrombin / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D001414:Bacitracin; C003903:Nebacetin; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin; D009355:Neomycin
vernacular_title: Klinische Erfahrungen mit einer Fibrin-Nebacetin-Spongiosaplombe zur Behandlung der chronischen Knocheninfektionen und als lokale Infektionsprophylaxe bei nicht infiziertem Knochenherd.