title: Kinetics of individual polychlorinated biphenyl (PCB) components in juvenile sole (Solea solea) in relation to their concentrations in food and to lipid metabolism.
abstract: PCBs were administered to juvenile soles (Solea solea) with food. Homogenates of gut, liver, brain, dark skin, muscle and gills were analysed for their contents of individual PCB components. The relative contributions of individual components to total PCB were virtually identical in the various organs sampled at the same day in a 275-day period. During the experiment concentrations on a (pentane-extractable) lipid basis of most PCB components declined in all organs regardless of lipid metabolism. The results suggest that PCB patterns in organs are determined by equilibrium partitioning. So components remained mobilizable from organs whose lipid contents increased. This is in contrast with the idea that PCBs are taken up and stored in lipids under circumstances of increasing lipid content in organs. The plateau-values of the steady-states of lipid based concentrations of PCB components decreased in all organs. This might have been due to changes in lipid contents or lipid composition in some organs.
mesh_terms: D000821:Animal Feed; D000818:Animals; D005399:Fishes / Q000378:metabolism*; D007700:Kinetics; D050356:Lipid Metabolism; D011078:Polychlorinated Biphenyls / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology; D012997:Solvents; D013696:Temperature; D013997:Time Factors; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D012997:Solvents; D014874:Water Pollutants, Chemical; D012965:Sodium Chloride; D011078:Polychlorinated Biphenyls