[Morphological composition and functions of the human blood coagulating and anticoagulating systems in prolonged exposure to low ammonia concentrations in a sealed environment].
A group of test subjects was kept in a chamber in which the ammonia concentrations 5.1 +/- 0.05 mg/m3 and 2.1 +/- 0.1 mg/m3 were maintained for 17 and 31 days, respectively; on days 22 and 38 the ammonia concentration was increased to 9.3 +/- 0.1 mg/m3. During this exposure, the morphological composition (red blood cells, hemoglobin, reticulocytes, platelets, white blood cells and their various types), as well as the coagulative-anticoagulative system (factor IV of platelets, index of blood clot retraction, recalcification time, thrombin time, ethanol and protamine sulphate paracoagulation tests, fibrinogen degradation products, fibrinolytic activity, fibrinogen and prothrombin content) were investigated. The parameters characterizing hemopoiesis and status of the coagulative-anticoagulative system did not show any significant changes. However, a slight decrease in the counts of leukocytes, neutrophils, eosinophils is of concern, because in space flight resistance to different infections declines.
D000641:Ammonia / Q000009:adverse effects*; D001773:Blood Cells / Q000187:drug effects*; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D018504:Ecological Systems, Closed; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D013997:Time Factors
D000641:Ammonia
Morfologicheskiĭ sostav i funktsii svertyvaiushcheĭ-antisvertyvaiushcheĭ sistem krovi u cheloveka pri dlitel'nom vozdeĭstvii malykh kontsentratsiĭ ammiaka v usloviiahk germoob"ekta.