Movement disorders with neuroleptic drug treatment.
Antipsychotic drugs produce several neurologic complications including acute dyskinesia, parkinsonism, neuroleptic malignant syndrome, akathisia, and tardive dyskinesia. Despite increased awareness of these syndromes, they continue to be underdiagnosed among patients receiving antipsychotic drugs. The clinical features, possible pathophysiologic mechanisms, and treatment of these conditions are discussed in this review.
D000208:Acute Disease; D017109:Akathisia, Drug-Induced; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D003937:Diagnosis, Differential; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis; D007980:Levodopa / Q000627:therapeutic use; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology; D010276:Parasympatholytics / Q000627:therapeutic use; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D011954:Receptors, Dopamine / Q000187:drug effects; D013997:Time Factors; D005879:Tourette Syndrome / Q000175:diagnosis
D014150:Antipsychotic Agents; D018492:Dopamine Antagonists; D010276:Parasympatholytics; D011954:Receptors, Dopamine; D007980:Levodopa; D004298:Dopamine