title: [Noveril treatment of patients with treatment-resistant depressions (comparative evaluation of technics of intravenous drip administration)].
abstract: Patients with manic-depressive psychosis, schizophrenia and traumatic encephalopathy were treated with noveril to control prolonged therapy resistant depressions. Noveril was used in the form of intravenous infusions given in courses in a dose of 720 ml/day with the subsequent transition to oral administration. In 21 patients (Group I), noveril was infused for two days while in another 14 patients (Group II), the course of intravenous infusions lasted ten days. The clinical effect of noveril was found to vary considerably depending on the regimen utilized. Positive clinical effect of the drug in group II manifested itself earlier and was higher than in group I, being 64.3% and 38.1%, respectively. The higher psychotropic activity of noveril with the ten-day intravenous infusion, major indications for its use and associated side effects are discussed. The question is raised concerning the specification of the notion of therapeutic resistance.
mesh_terms: D000284:Administration, Oral; D001714:Bipolar Disorder / Q000188:drug therapy*; D001930:Brain Injuries / Q000150:complications*; D003866:Depressive Disorder / Q000188:drug therapy*; D003984:Dibenzazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy*; D013577:Syndrome; D013997:Time Factors
chemical_list: D003984:Dibenzazepines
vernacular_title: Lechenie noverilom bol'nykh s terapevticheski rezistentnymi depressiiami (sravnitel'naia otsenka metodik vnutrivenno kapel'no vvedeniia).