Structure re-assignment of a metabolite of ampicillin and amoxycillin and epimerization of their penicilloic acids.
Products formed in-vitro from ampicillin and amoxycillin penicilloates have been examined by high-performance liquid chromatography, ultraviolet and nuclear magnetic resonance spectroscopy and thiol group determination and were found to be the 5S epimers of the penicilloic acids. This is in contrast to a published claim that the corresponding penamaldic acids were formed by the treatment used.
D000658:Amoxicillin / Q000032:analysis*; D000667:Ampicillin / Q000032:analysis*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D010397:Penicillanic Acid / Q000032:analysis* / Q000031:analogs & derivatives; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000032:analysis
D013438:Sulfhydryl Compounds; C008782:penicilloic acid; D000667:Ampicillin; D000658:Amoxicillin; D010397:Penicillanic Acid