The effect of parasitization by Leishmania mexicana mexicana on macrophage function in vitro.
Macrophages infected with amastigotes of Leishmania mexicana mexicana as compared to normal macrophages show decreased migration both randomly and through a 5 microns pore in response to a known chemotaxin, an increased ability to pinocytose and an increased bactericidal ability. Unless very heavily parasitized their ability to phagocytose is unaltered. Parasitized macrophages are unaltered in their ability to secrete extracellularly lysosomal enzymes, prostaglandins and lysozyme in response to known stimuli, or to kill target cells in an antibody dependent cell mediated cytotoxicity assay.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001770:Blood Bactericidal Activity; D002464:Cell Migration Inhibition; D066298:In Vitro Techniques; D007891:Leishmania / Q000276:immunology*; D008247:Lysosomes / Q000378:metabolism; D008264:Macrophages / Q000276:immunology* / Q000502:physiology; D051379:Mice; D010587:Phagocytosis; D010873:Pinocytosis