Induction in rainbow trout of an acute phase (C-reactive) protein by chemicals of environmental concern.
1. Rainbow trout, Salmo gairdneri, produce elevated amounts of a serum acute phase (C-reactive) protein (CRP) when administered a variety of chemicals of environmental importance. 2. Compounds administered in doses which induce the cytochrome(s) P450 catalytic enzymes in trout hepatic microsomes also induce serum CRP. 3. However, an interferon-inducing virus does not induce CRP. Interferon induction by the virus is not significantly inhibited by chemicals which induce trout cytochrome(s) P450. 4. Simultaneous administration of chemicals and virus or virus alone results in depression of P450 protein production and only minor induction of CRP. 5. Thus, as with mammals, a reciprocating relationship appears to exist between the hemeprotein monooxygenase and immune systems of this freshwater teleost, and C-reactive protein appears to fit the reciprocating scheme closer to the cytochromes P450 response.
D000818:Animals; D002097:C-Reactive Protein / Q000097:blood*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D005260:Female; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D012487:Salmonidae / Q000097:blood*; D014337:Trout / Q000097:blood*; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D014877:Water Pollution, Chemical
D007306:Insecticides; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D008748:Methylcholanthrene; D002097:C-Reactive Protein; D003577:Cytochrome P-450 Enzyme System