title: [Bufuralol: do beta blockers reduce blood circulation in the kidneys?].
abstract: In 8 ambulatory patients with stable essential hypertension (WHO grade I and II) the effects of a new beta-blocker with marked sympathomimetic activity on arterial blood pressure, creatinin clearance and renal plasma flow, as measured by total PAH clearance (constant infusion technique), were studied. In contrast to previous findings no significant reduction in creatinin clearance or renal blood flow was observed during a 3-5 weeks' observation period. The small reduction in calculated renal vascular resistance was not statistically significant. In addition to its postulated peripheral vasodilatory effect, bufuralol appears to interfere less than propranolol with renal hemodynamics and renal excretory function.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000494:pharmacology; D000328:Adult; D004983:Ethanolamines / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; C010831:bufuralol
vernacular_title: Bufuralol: reduzieren beta-blocker die Nierendurchblutung?