title: A potent, structurally specific stimulant action of procaine in bullfrog lung.
abstract: 1. Local anesthetics with a procaine-like structure are exceptionally potent smooth muscle stimulation in Rana catesbeiana. 2. Procaine completely reverses the relaxant effect of 1 mM theophylline, an action that cannot be duplicated with carbachol, histamine or 5-hydroxytryptamine. 3. Stimulant activity is related to the procaine-like structure rather than local anesthetic potency, and is independent of pH between 7.0 and 8.4. 4. The high potency and structural specificity of this effect suggests an action at a specific receptor site rather than a diffuse action on membrane structure.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008012:Lidocaine / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D011343:Procaine / Q000494:pharmacology*; D011892:Rana catesbeiana; D013270:Stomach / Q000187:drug effects; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000494:pharmacology
chemical_list: D011343:Procaine; D001285:Atropine; D008012:Lidocaine; D013806:Theophylline; D000109:Acetylcholine