[Dynamics of the change in Na, K-ATPase activity during the development of isoproterenol-induced myocardial necrosis in rats].
Na, K-ATPase activity of heart tissue homogenates was found to be depressed 6 and 24 h after the last injection of isoproterenol to rats (100 mg/kg s. c. daily for 2 consecutive days) whereas after 1 h it was essentially unchanged. The extent of the reduction in the enzyme activity was virtually the same both 6 and 24 h after myocardial necrosis induction (18 and 19%, respectively). The time-course of changes in the activity of the sarcolemmal marker enzyme was compared to the reported data on the increased sarcolemmal permeability in isoproterenol-induced myocardial necrosis.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D008024:Ligands; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D012508:Sarcolemma / Q000187:drug effects / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013997:Time Factors
D008024:Ligands; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D007545:Isoproterenol
Dinamika izmeneniia Na, K-ATFaznoĭ aktivnosti v protsesse razvitiia vyzvannogo izoproterenolom nekroza miokarda krys.