Low concentrations of potassium inhibit the Na-dependent [3H]glutamate binding to rat hippocampal membranes.
Potassium at low concentrations was found to inhibit the Na-dependent [3H]L-glutamate binding to rat hippocampal synaptic membranes. This inhibition was probably due to a competition between potassium and sodium at the ionic locus of the recognition site for glutamate of the uptake process. In addition, potassium inhibited the high-affinity [3H]L-glutamate uptake in hippocampal synaptosomes. These results provide an additional mechanism for the spreading of depression which accompanies seizure activity in the hippocampus.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000378:metabolism*; D066298:In Vitro Techniques; D008566:Membranes / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000502:physiology*; D013570:Synaptic Membranes / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism
D005971:Glutamates; D018698:Glutamic Acid; D011189:Potassium Chloride; D012964:Sodium; D011188:Potassium