Effects of maternal ethanol ingestion on cerebral neurotransmitters and cyclic-AMP in the rat offspring.
1. To study the effects of maternal alcohol ingestion on brain parameters in offspring, rats were given ethanol for drinking (25% w/v) from the time of mating until sacrifice. Controls drank tap water. 2. Alcohol ingestion reduced daily food and liquid consumption but total caloric intake was only slightly diminished. 3. Maternal body weight increased and offspring body weight, size and brain weight were reduced in the animals receiving alcohol. 4. Brain concentrations of tryptophan, tyrosine and GABA were augmented in ethanol treated mothers at 1 day post-partum. 5. Comparison of brain parameters in offspring of alcoholic mothers with those of controls showed that tryptophan and 5HT concentrations were augmented in 4 day old neonates, NA was increased in 21 day fetuses and 1 day old neonates, and adenylate cyclase activity was also greater in the brains of 21 day fetuses and the cerebellums of 4 day old neonates. 6. Neither phosphodiesterase nor cyclic-AMP concentrations differed in offspring of alcoholic and control mothers. 7. Data showed alterations in brain NA and 5HT systems in the offspring of alcoholic mothers.
D000588:Amines / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism
D000588:Amines; D000596:Amino Acids; D018377:Neurotransmitter Agents; D012701:Serotonin; D000431:Ethanol; D000242:Cyclic AMP; D009638:Norepinephrine