Decreased disrupting effect of neuroleptics on conditioned avoidance in rats with lesions in the mid-brain raphe nuclei.
The present study evaluated the effects of some neuroleptics (Chlorpromazine, haloperidol, spiroperidol) on general activity and avoidance behavior (one-way and two-way) in rats with lesions in the midbrain raphe nuclei (the nucleus raphe medianus and nucleus raphe dorsalis). Animals with lesions showed reduced response to neuroleptics when compared with sham-operated animals. The resistance of raphe-lesioned rats to neuroleptics is discussed on the basis of possible interaction between catecholamine and serotonin brain neurons.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001933:Brain Stem / Q000502:physiology*; D002746:Chlorpromazine / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology; D013134:Spiperone / Q000494:pharmacology
D014150:Antipsychotic Agents; D012701:Serotonin; D013134:Spiperone; D006220:Haloperidol; D002746:Chlorpromazine