Action of aspartate on the 32Pi incorporation into phospholipids of cerebral cortex.
The effect of L-aspartate on the 32Pi incorporation of phospholipids, was studied on slices of rat cerebral cortex. This amino acid produced an inhibitory effect in concentrations 0.01-10 mM, which was more evident at 120 min. This effect was not stereospecific and did not imply a change in Pi uptake and in nucleotides approximately P precursors. The inhibition was present in PS, PC, PE and to a lesser extent in PI. On liver slices 1 mM L-aspartate had the opposite effect, stimulating the incorporation of 32Pi into total phospholipids. Our results suggest that the effect of L-aspartate is by a non-specific mechanism, probably not mediated by a receptor.
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism*; D010761:Phosphorus Radioisotopes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects
D018377:Neurotransmitter Agents; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D001224:Aspartic Acid