Effects of excitatory amino acids on dopamine synthesis in the rat retina.
Intraocular administration of quisqualate but not of N-methyl-D-aspartate or kainate augments dopamine synthesis in the retinas of dark-maintained rats. The effect of quisqualate is dosage-dependent but not blocked by the glutamate antagonist, glutamate diethyl ester. These results are the first to show that the quiescent dopamine neurons of the dark-adapted rat retina can be activated by an excitatory amino acid analogue of the putative endogenous neurotransmitter, glutamate.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D004298:Dopamine / Q000096:biosynthesis*; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects* / Q000378:metabolism
D000596:Amino Acids; D005971:Glutamates; D010069:Oxadiazoles; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D007608:Kainic Acid; D004298:Dopamine