Tumor cells adhere to intraperitoneal injection sites.
Tumor cells injected intraperitoneally form cell plaques at injection sites in the abdominal wall of mice within a few minutes. Tumor cells appear to be transported passively and chemotactic factors are not involved. Dihydrocortisol blocks cell adherence and silica particles , assumed to destroy macrophages, abolish cell plaque formation.
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002633:Chemotaxis; D006854:Hydrocortisone / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009366:Neoplasm Seeding; D009369:Neoplasms / Q000503:physiopathology*; D010537:Peritoneum / Q000503:physiopathology*; D012822:Silicon Dioxide / Q000494:pharmacology; D013997:Time Factors
D012822:Silicon Dioxide; D006854:Hydrocortisone