title: Synchronous epileptiform bursts without chemical transmission in CA2, CA3 and dentate areas of the hippocampus.
abstract: Slices of rat hippocampus maintained in a medium containing Mn2+ and lowered Ca2+ concentration, which demonstrably blocked chemical synapses, generated spontaneous bursts of population spikes in all cell body layers after 30-60 min of incubation. Therefore, electrical interactions alone can synchronize neuronal activity in the hippocampus, and they are probably important during epileptiform events.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D046508:Culture Techniques; D004827:Epilepsy / Q000503:physiopathology*; D005071:Evoked Potentials; D006624:Hippocampus / Q000503:physiopathology*; D008274:Magnesium / Q000378:metabolism; D009474:Neurons / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D018377:Neurotransmitter Agents; D008274:Magnesium; D002118:Calcium