Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines.
9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] did not undergo metabolic changes in any of the eleven cell lines tested. In these, it exhibited a varying antiviral activity against vesicular stomatitis virus (VSV), which appeared to correlate with the relative amounts of (S)-DHPA that had become cell-associated during virus infection.
D000225:Adenine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D002415:Cats; D002460:Cell Line; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D011817:Rabbits; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000998:Antiviral Agents; C016391:9-(2,3-dihydroxypropyl)adenine; D000225:Adenine