Interactions of cholecystokinin octapeptide and dopamine on nucleus accumbens neurons.
Local microiontophoretic administration of cholecystokinin octapeptide (CCK) increased the firing rates of neurons in the dorsomedial nucleus accumbens (NAc), but exerted little to no effect on lateral NAc neurons. This regionally defined CCK-effect corresponds to the topographical distribution of CCK-like immunoreactive nerve terminal fiber networks and CCK receptors within the NAc. The excitatory effects of CCK were selectively antagonized by the CCK antagonist proglumide. Dopamine (DA) decreased the firing of NAc cells and reversed CCK-induced excitation. These results suggest that CCK and DA may interact to influence the activity of neurons within the dorsomedial NAc.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D004347:Drug Interactions; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006801:Humans; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects*; D011377:Proglumide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000502:physiology; D011949:Receptors, Cholecystokinin; D012559:Schizophrenia / Q000188:drug therapy; D012686:Septal Nuclei / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology
D014150:Antipsychotic Agents; D005971:Glutamates; D011956:Receptors, Cell Surface; D011949:Receptors, Cholecystokinin; D018698:Glutamic Acid; D011377:Proglumide; D012844:Sincalide; D004298:Dopamine