Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation.
Microiontophoretic application of the histamine H2-receptor antagonist cimetidine selectively attenuated the histamine-induced, but not the gamma-aminobutyric acid (GABA)-induced, depression of serotoninergic cells recorded in the dorsal raphe nucleus of the rat. These data support the view that an H2-receptor mediates the effects of histamine on these serotoninergic neurons. We also now ascribe a previous report of GABA-like properties of cimetidine and metiamide to an impurity in the lots of these compounds used originally.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007478:Iontophoresis / Q000379:methods; D008297:Male; D009118:Muscimol / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D006635:Histamine H2 Antagonists; D009118:Muscimol; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D002927:Cimetidine; D006632:Histamine