Relationship between plasma concentration and arousal in normal subjects after single oral and parenteral doses of melperone, a butyrophenone neuroleptic.
The relationship between plasma concentration and effect on arousal was studied in normal subjects after single oral and parenteral doses of melperone. A strong correlation between plasma concentration and effect was found when the effector compartment and central compartment were in equilibrium. The relationship was independent of the route of administration.
D000284:Administration, Oral; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002090:Butyrophenones / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004562:Electrocardiography; D005425:Flicker Fusion / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives; D007267:Injections; D008297:Male
D014150:Antipsychotic Agents; D002090:Butyrophenones; D006993:Hypnotics and Sedatives; C008522:metylperon