Metabolism of amrinone in animals.
The biotransformation of 14C-amrinone was studied in rats, dogs, and monkeys by automated gradient high-performance liquid chromatography. The major pathways of metabolism elucidated are: A) glucuronidation at the primary amino nitrogen atom and/or the enolized oxygen atom of the pyridone ring; B) addition of glutathione at the pyridone 2-position and ultimate hydrolysis of this compound to the 2-S-cysteinyl metabolite; C) formation of the primary amino N-acetyl derivative and subsequent oxidation of this to the corresponding N-glycolate. In each species studied, urine was the primary route of elimination and unchanged amrinone was the major urinary excretion product, the other known pathways being: rat, A and C; dog, A and B; monkey, A.
D000284:Administration, Oral; D000631:Aminopyridines / Q000008:administration & dosage / Q000378:metabolism*; D000676:Amrinone; D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005260:Female; D005965:Glucuronates / Q000652:urine; D006016:Glycolates / Q000652:urine; D008658:Inactivation, Metabolic; D008253:Macaca mulatta; D051381:Rats; D011919:Rats, Inbred Strains
D000631:Aminopyridines; D002316:Cardiotonic Agents; D005965:Glucuronates; D006016:Glycolates; D000676:Amrinone