Stress- and (1-24)ACTH-induced alterations in adrenal and testicular steroidogenesis in Mongolian gerbils (Meriones unguiculatus): comparison of plasma levels, tissue content and in vitro secretion.
Plasma glucocorticosteroid levels were significantly elevated 1 hr after confinement stress or (1-24)ACTH administration. Both adrenal content and in vitro secretion of glucocorticosteroids and progesterone from adrenals of stressed or (1-24)ACTH-injected animals were higher than values measured in controls. Neither adrenal testosterone content nor output of testosterone or progesterone from superfused testes were changed. Significant correlations were obtained between glucocorticosteroid plasma levels and corresponding adrenal content/in vitro secretion, adrenal progesterone content and output, and between adrenal glucocorticosteroid and progesterone content.
D000305:Adrenal Cortex Hormones / Q000097:blood / Q000378:metabolism*; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D003366:Cosyntropin / Q000494:pharmacology*; D005849:Gerbillinae / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D011374:Progesterone / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*; D013737:Testis / Q000187:drug effects / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D003366:Cosyntropin; D011374:Progesterone; D000324:Adrenocorticotropic Hormone