Beta-adrenoceptor blocker pharmacokinetics and the oral contraceptive pill.
Higher AUC and Cmax values were obtained for metoprolol, oxprenolol and propranolol in groups receiving the low-dose oestrogen-ethinyl oestradiol oral contraceptive, but statistical significance was reached only with metoprolol AUC. The oral contraceptive had the opposite effect on acebutolol AUC and Cmax but this was not significant. The oral contraceptive had no detectable effects on the tmax and t 1/2 values of any of the beta-adrenoceptor blockers.
D000070:Acebutolol / Q000378:metabolism; D000319:Adrenergic beta-Antagonists / Q000378:metabolism*; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007700:Kinetics; D008790:Metoprolol / Q000378:metabolism; D010096:Oxprenolol / Q000378:metabolism; D011433:Propranolol / Q000378:metabolism; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D010096:Oxprenolol; D000070:Acebutolol; D011433:Propranolol; D008790:Metoprolol