[Effect of antihistaminic agents on the blood supply to the brain in stimulation of the vestibular apparatus].
It has been established in chronic experiments on intact rabbits by the hydrogen clearance method that stimulation of the vestibular apparatus leads to an appreciable increase in the overall brain blood flow and in the regional blood flow in the frontal, occipital and temporal areas of the brain along with the development of motion sickness. Intravenous injections of diprazine (1 mg/kg) and suprastin (2 mg/kg) noticeably reduce the brain vascular reactions during vestibular disorders, diminish or prevent the increased blood flow in the brain or in its individual areas, occurring in motion disease of animals.
D000054:Acceleration; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004567:Electrodes, Implanted; D006439:Hemodynamics / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D009041:Motion Sickness / Q000503:physiopathology; D011817:Rabbits; D013997:Time Factors; D014722:Vestibule, Labyrinth / Q000502:physiology*
D006634:Histamine H1 Antagonists
Vliianie antigistaminnykh sredstv na krovosnabzhenie golovnogo mozga pri razdrazhenii vestibuliarnogo apparata.