title: Plasma pyroglutamic acid levels after oral administration of monosodium glutamate to human volunteers.
abstract: Plasma levels of pyroglutamic (PY) and glutamic (GA) acids have been measured after oral administration of monosodium glutamate (MSG) to 6 human volunteers. MSG (43 mg/kg) was administered either after an overnight fast or immediately after a normal meal. In fasting subjects plasma GA peak levels were about 2.3 times the basal levels whereas the increase in plasma PY levels were only 1.5-fold. When MSG was administered with a meal plasma GA levels were raised, to a lesser extent, while no increase could be observed in plasma PY.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005971:Glutamates / Q000097:blood / Q000378:metabolism*; D018698:Glutamic Acid; D006801:Humans; D008297:Male; D011760:Pyrrolidinones / Q000097:blood*; D011761:Pyrrolidonecarboxylic Acid / Q000097:blood*; D012970:Sodium Glutamate / Q000378:metabolism*
chemical_list: D005971:Glutamates; D011760:Pyrrolidinones; D018698:Glutamic Acid; D011761:Pyrrolidonecarboxylic Acid; D012970:Sodium Glutamate