The effect of gamma-hydroxybutyrate and anticonvulsants on opioid peptide content in the rat brain.
Gamma-hydroxybutyrate administered in anaesthetic doses produced a profound increase in the levels of dynorphin A (DYN) in the hippocampus and pituitary. Simultaneously, a significant, short-lasting decrease in beta-endorphin (B-E) levels occurred in the brain and pituitary. Antiepileptic drugs strongly, though in various ways, influenced the brain DYN and B-E concentrations; though most of them caused a decrease in the hypothalamic opioid peptide content.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004399:Dynorphins; D004723:Endorphins / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012978:Sodium Oxybate / Q000494:pharmacology*; D001615:beta-Endorphin
D000927:Anticonvulsants; D004723:Endorphins; D006885:Hydroxybutyrates; D001615:beta-Endorphin; D004399:Dynorphins; D012978:Sodium Oxybate