[Prevention and therapy of delirium tremens with tiapride and chlordesmethyldiazepam].
Forty alcohol abusers (with a history of long-time alcohol addiction and mean daily use over 360 grams of alcohol) were treated with tiapride or chlordesmethyldiazepam when stopped their overdrinking. The aim of such pharmacological treatment was both a valuation of effectiveness towards ten target-symptoms and the attempt to avoid the development of a withdrawal syndrome-or, at least, to shorten its course. Chlordesmethyldiazepam resulted to be on the whole more effective than tiapride in dominating all most dramatic symptoms of Delirium Tremens and in avoiding--in a significantly higher number of patients--the onset of a DT syndrome in all its typical features. Moreover, CDDz appeared as a manageable drug and free from important side-effects, and could control symptoms without need of further therapies.
D000328:Adult; D000368:Aged; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy* / Q000517:prevention & control; D000437:Alcoholism / Q000188:drug therapy; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D001569:Benzodiazepines; D003975:Diazepam / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011604:Psychoses, Alcoholic / Q000188:drug therapy*; D013976:Tiapamil Hydrochloride / Q000627:therapeutic use*
D014151:Anti-Anxiety Agents; D001549:Benzamides; D001569:Benzodiazepines; D003708:Nordazepam; C013434:chlordesmethyldiazepam; D003975:Diazepam; D013976:Tiapamil Hydrochloride
Prevenzione e terapia del delirium tremens con tiapride e clordemetildiazepam.