Effects of solvent medium on solubility. A linear free energy relationship treatment.
Linear relationships exist between the logarithms of the solubility equilibria of structurally closely related compounds, as they vary with changes in solvent or solvent composition in water and water-like solvents. The slope Py of these linear free energy relationships quantitatively accounts for the direction and intensity of the relative solubility variations due to medium effects. Results obtained by applying the concept to series of both p-hydroxy-and p-aminobenzoic esters, and alpha-aminoacids, are presented. These results are explained by a simple model in terms of solute-solvent interactions.
D010129:4-Aminobenzoic Acid; D002626:Chemistry, Pharmaceutical; D003510:Cyclohexanes; D000431:Ethanol; D062385:Hydroxybenzoates; D008956:Models, Chemical; D012995:Solubility; D012997:Solvents; D013816:Thermodynamics; D014867:Water
D003510:Cyclohexanes; D062385:Hydroxybenzoates; D012997:Solvents; D014867:Water; D000431:Ethanol; D010129:4-Aminobenzoic Acid