title: Effects of hyperthermia on plasma glycoprotein catabolism by the isolated perfused rat liver.
abstract: Clearance and degradation of the glycoprotein, asialofetuin (AF), by the isolated perfused rat liver at supranormal temperatures were investigated. The half-life for disappearance of AF was similar at 37, 41, and 42 degrees C, P greater than 0.05. There was a significant difference between the amount of hydrolysis of AF at 37, 41, and 42 degrees C, P less than 0.05. This indicates that there was significant retardation of lysosomal proteolysis or receptor endocytosis by the hepatocyte at elevated temperatures.
mesh_terms: D000818:Animals; D006023:Glycoproteins / Q000097:blood / Q000378:metabolism*; D006358:Hot Temperature; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D006023:Glycoproteins; D007457:Iodine Radioisotopes