[Effect of tranquilizing agents on the blood level of endogenous ethanol in alcoholics].
Experiments on alcohol addicts blood were made to study the time course of the endogenous ethanol level after a single administration of mebicar (1.5 g), a derivative of bicyclic bisuria, 50 ml of 5% sodium hydroxybutyric syrup, a derivative of gamma-hydroxybutyric acid, and 20 mg diazepam, a derivative of 1,4-benzodiazepines. The clinical effect was recorded simultaneously. It was established that different tranquilizers stimulate the increase in the endogenous ethanol level as regards the spectrum of psychotropic activity. This effect was the most pronounced with mebicar and to a less measure with diazepam.
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy*; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001569:Benzodiazepines; D001736:Biureas / Q000627:therapeutic use; D000431:Ethanol / Q000097:blood*; D006801:Humans; D008297:Male; D012978:Sodium Oxybate / Q000627:therapeutic use; D014149:Tranquilizing Agents / Q000627:therapeutic use*
D014151:Anti-Anxiety Agents; D001736:Biureas; D014149:Tranquilizing Agents; C015979:mebikar; D001569:Benzodiazepines; D000431:Ethanol; D012978:Sodium Oxybate
Vliianie trankvilizatorov na uroven' éndogennogo étanola v krovi bol'nykh alkogolizmom.