[Relation between thymosin fraction 5, prostaglandin release and Thy-1 antigen appearance in mice lymphocytes].
Incubation with Thymosin Fraction 5 induces a dose-dependent release of PGE2 by lymphocytes obtained from adult thymectomized mice; Indomethacin inhibits this effect. The same result was not observed in lymphocytes obtained from normal mice. PGE2 release is correlated with Thy-1 appearance on Thy-1 negative lymphocytes, after incubation with Thymosin, valutated with Bach's rosette inhibition test.
D000818:Animals; D000954:Antigens, Surface / Q000096:biosynthesis*; D015232:Dinoprostone; D007213:Indomethacin / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011458:Prostaglandins E / Q000097:blood*; D018800:Thy-1 Antigens; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000954:Antigens, Surface; D011458:Prostaglandins E; D018800:Thy-1 Antigens; C033782:thymosin fraction 5; D013947:Thymosin; D015232:Dinoprostone; D007213:Indomethacin
Correlazione tra timosina Fr 5, rilascio di prostaglandine e comparsa dell'antigene Thy-1 in linfociti di topo.