The periaqueductal gray-raphe magnus projection contains somatostatin, neurotensin and serotonin but not cholecystokinin.
The retrograde transport-HRP-immunocytochemical technique was employed to ascertain if the periaqueductal gray-raphe magnus projection arises from neurons containing somatostatin, neurotensin, serotonin or cholecystokinin. Following HRP injections into the raphe magnus (NRM) double-labeled cells containing HRP reaction product and somatostatin-, neurotensin- or serotonin-like immunoreactivity were identified in the midbrain periaqueductal gray (PAG). No cholecystokinin-like immunoreactive double-labeled neurons were found in the PAG. These results indicate that the PAG-NRM pathway contains somatostatin, neurotensin and serotonin but not cholecystokinin.
D000818:Animals; D001933:Brain Stem / Q000033:anatomy & histology*; D002766:Cholecystokinin / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology; D009474:Neurons / Q000648:ultrastructure; D009496:Neurotensin / Q000378:metabolism*; D009619:Nociceptors / Q000033:anatomy & histology; D010487:Periaqueductal Gray / Q000033:anatomy & histology*; D011903:Raphe Nuclei / Q000033:anatomy & histology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism*
D012701:Serotonin; D009496:Neurotensin; D013004:Somatostatin; D002766:Cholecystokinin