[Effect of the adrenaline, euphyllin, phentolamine and obzidan on serotonin bronchospasm in guinea pigs].
It has been shown in experiments on 81 guinea-pigs that variation of the functional status of alpha- and beta-adrenoreceptors produces a substantial effect on marked serotonin bronchospasm. The blockade of beta-adrenoreceptors with obsidan (1--2 mg/kg) increases the spasm of bronchial smooth muscles in response to serotonin (10 micrograms/kg). The alpha-adrenolytic phentolamine (2 mg/kg) and the myotropic spasmolytic euphylline (8 mg/kg) remove the hypersensitivity of the bronchi to serotonin 20 min after adrenaline administration and potentiate its protective effect in serotonin bronchospasm after administering the beta-adrenoblocker obsidan.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000628:Aminophylline / Q000627:therapeutic use*; D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced* / Q000188:drug therapy; D004837:Epinephrine / Q000627:therapeutic use*; D006168:Guinea Pigs; D010646:Phentolamine / Q000627:therapeutic use*; D011433:Propranolol / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D012702:Serotonin Antagonists; D000628:Aminophylline; D011433:Propranolol; D004837:Epinephrine; D010646:Phentolamine
Vliianie adrenalina, éufillina, fentolamina i obzidana na serotoninovyĭ bronkhospazm u morskikh svinok.