The effect of carazolol on the cardiovascular responses to adrenaline in stress sensitive pigs.
The effect of propranolol, carazolol and acebutolol on the heart rate and blood pressure responses to intravenous adrenaline were examined in conscious Pietrain pigs. All three drugs blocked the tachycardia and vasodilatory responses to adrenaline and induced an increase in vasopressor responsiveness. The likely complications from using non-cardioselective beta blockers for preventing stress-induced deaths in pigs are discussed.
D000070:Acebutolol / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004837:Epinephrine / Q000037:antagonists & inhibitors*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011292:Premedication / Q000662:veterinary; D011412:Propanolamines / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D011433:Propranolol / Q000494:pharmacology; D013312:Stress, Physiological / Q000188:drug therapy / Q000662:veterinary; D013552:Swine / Q000502:physiology*; D013553:Swine Diseases / Q000188:drug therapy
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C014382:carazolol; D000070:Acebutolol; D011433:Propranolol; D004837:Epinephrine