Flubendazole versus mebendazole in intestinal helminthic infections.
In a double-blind study the vermicidal effect of flubendazole, a new benzimidazole derivative, was evaluated and compared to mebendazole. Both drugs were administered in a single dose of 600 mg. While in the treatment of Ascaris and hookworm infestations flubendazole and mebendazole showed a similar efficacy, mebendazole seemed to be slightly superior in the treatment of trichuriasis. Both drugs were well tolerated and no side effects were observed even in patients with a heavy worm load.
D000293:Adolescent; D000328:Adult; D001196:Ascariasis / Q000188:drug therapy; D001562:Benzimidazoles / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006725:Hookworm Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000031:analogs & derivatives / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy*; D013622:Taeniasis / Q000188:drug therapy*; D014257:Trichuriasis / Q000188:drug therapy
D001562:Benzimidazoles; D008463:Mebendazole; C018945:flubendazole