The effect of five drugs in coma doses on neurotransmitter amino acids in the brains of guinea pigs.
The study has been carried out in order to investigate the effects of some drugs in coma doses on the concentration in brain of some amino acids involved in brain function. Six groups of 25 guinea pigs each were utilized. In each of the five groups a subcutaneous dose of diazepam, flunitrazepam, phenobarbital, phenytoin or alfaxalone, was injected and one group was utilized as control. Some neurotransmitter amino acids (glutamate, aspartate, glycine and taurine) and precursors of neurotransmitters (phenylalanine and tyrosine) were determined in brain preparations. The results are discussed.
D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry; D002491:Central Nervous System Agents / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D005445:Flunitrazepam / Q000494:pharmacology; D006168:Guinea Pigs; D018377:Neurotransmitter Agents / Q000032:analysis*; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D011277:Pregnanediones / Q000494:pharmacology
D000596:Amino Acids; D002491:Central Nervous System Agents; D002492:Central Nervous System Depressants; D018377:Neurotransmitter Agents; D011277:Pregnanediones; D010672:Phenytoin; D005445:Flunitrazepam; C006477:alphaxalone; D003975:Diazepam; D010634:Phenobarbital