A role for somatostatin in the impaired insulin secretory response to glucose by islets from aging rats.
The purpose of this study was to investigate a possible contribution by somatostatin to the impairment in glucose-stimulated secretion of insulin during aging. Pancreatic islets of Langerhans were isolated from male Sprague-Dawley rats aged 2- to 24-months and challenged in vitro with effectors of insulin secretion. Concentrations of insulin, glucagon, and somatostatin were determined by radioimmunoassay. The impairment of glucose-stimulated secretion of insulin which characterizes islets isolated from aged rats may be overcome by treatment of islets with antibodies to somatostatin. Enhanced availability and/or effectiveness of endogenous pancreatic somatostatin during aging may be responsible for the modified pattern of glucose-stimulated secretion of insulin.
D000375:Aging; D000818:Animals; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
D007328:Insulin; D013004:Somatostatin; D005947:Glucose