title: Survey with follow-up of 67 dogs with testicular sertoli cell tumours.
abstract: Sixty-seven cases of canine sertoli cell tumour are reviewed. The mean age at diagnosis was 9.5 years (sd +/- 2.1, range 3 to 17). The most commonly affected breeds were boxer, cairn terrier, labrador retriever, border collie, German shepherd and rough collie. The left side was affected in 28 dogs (42 per cent), the right in 35 (52.5 per cent) and both sides in four (6 per cent). Twenty testicles were abdominal (left, seven; right, 13), seven were inguinal (left, four; right, three) and 44 were scrotal (left, 21; right, 23). Hormonal signs were evident in 38 (57 per cent) animals (feminisation with alopecia in 21, symmetrical alopecia alone in 17). Other types of testicular tumours were found in 12 dogs (18 per cent) of this series. Of 42 dogs which were castrated and discharged, 38 were available for follow-up study and survived for between one week and five years. Two of the 15 dogs which were subject to post mortem examination had metastases. Two others which died after failure of remission, or a recurrence of the hormonal changes probably also had metastases. Two of the 25 dogs which were presented initially for other reasons, but had sertoli cell tumours, were found to have metastases post mortem. The boxer, cairn terrier, border collie, Shetland collie and pekingese had a higher risk of sertoli cell tumour than other breeds.
mesh_terms: D000818:Animals; D002369:Castration; D003456:Cryptorchidism / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology* / Q000601:surgery; D004285:Dogs; D005262:Feminization / Q000662:veterinary; D008297:Male; D009362:Neoplasm Metastasis; D012707:Sertoli Cell Tumor / Q000473:pathology / Q000662:veterinary*; D013736:Testicular Neoplasms / Q000473:pathology / Q000662:veterinary*