Differential sensitivity of selected rat brain areas to excitatory neurotransmitters released by K+ depolarization.
The depolarization of brain slices by high K+ concentrations in the presence of Ca2+ ions leads to the release from nerve terminals of endogenous excitatory neurotransmitters that interact with subsynaptic receptors controlling the neuronal membrane permeability to Na+ ions. This interaction has been studied by following the K+-evoked Ca2+-dependent 22Na+ efflux from 22Na+-preloaded slices from the cortex, striatum, hippocampus, cerebellum, substantia nigra and hypothalamus of the rat. The results indicate that the so-called N-methyl-D-aspartate receptor mediates the bulk of the excitatory transactions in the cortex and striatum whereas a subsynaptic glutamate receptor may mediate those in the hippocampus and cerebellum.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D066298:In Vitro Techniques; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D012964:Sodium / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects
D018377:Neurotransmitter Agents; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D012964:Sodium; D011188:Potassium