title: The effects of somatostatin on serum growth hormone levels in the goldfish, Carassius auratus.
abstract: In the present study the effects of somatostatin on serum growth hormone (GH) levels in the goldfish, Carassius auratus, were investigated. A single intraperitoneal injection of either 0.1 or 1.0 micrograms somatostatin/g body wt caused a significant decrease in serum GH levels at 1 h postinjection compared to vehicle-injected controls. Two intraperitoneal injections of somatostatin (1.0 micrograms/g body wt), given 12 hr apart, caused a significant decrease in serum GH levels, compared to both presample and vehicle-injected control groups at 1.5 and 6 hr following the second injection. In fish given two injections of somatostatin, a post inhibitory rebound in serum GH levels occurred by 24 hr following the second injection. Thyrotropin-releasing hormone (1 micrograms/g body wt), given as a control peptide, caused a significant increase in serum GH levels at 24 hr, but no significant changes were found at 1.5 or 6 hr following the second of two intraperitoneal injections given 12 hr apart. The increases in serum GH at 24 hr may be due to stress. The results demonstrate that somatostatin causes a transient decrease in blood GH levels in goldfish.
mesh_terms: D000818:Animals; D005260:Female; D006054:Goldfish; D013006:Growth Hormone / Q000097:blood*; D007700:Kinetics; D008297:Male; D012741:Sexual Maturation; D013004:Somatostatin / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
chemical_list: D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone