Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.
Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.
D001483:Base Sequence; D002116:Calcitonin / Q000235:genetics*; D015740:Calcitonin Gene-Related Peptide; D002460:Cell Line; D004247:DNA / Q000032:analysis; D005786:Gene Expression Regulation; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D013964:Thyroid Neoplasms / Q000032:analysis / Q000235:genetics
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D011061:Poly A; D002116:Calcitonin; D004247:DNA; D015740:Calcitonin Gene-Related Peptide