Pregnancy following combined therapy with thyroid hormone and bromocriptine in a patient with amenorrhea-galactorrhea due to primary hypothyroidism.
Combined therapy with thyroid hormone (desiccated thyroid) and bromocriptine (CB-154) was applied in a 29-year-old patient with amenorrhea-galactorrhea due to primary hypothyroidism. Two months after commencing administration of desiccated thyroid, the elevated serum level of TSH returned to the normal range while that of PRL remained within the supranormal range (from 134 ng/ml to 86.7 ng/ml). However, it fell to the normal range 2 weeks after administration of CB-154 with thyroid hormone. Subsequently, the galactorrhea completely ceased and ovulatory menstruation resumed with 3 months, and conception was achieved directly after that menstrual period. Only desiccated thyroid was administered during pregnancy and the patient delivered a male infant weighing 2,800 g without difficulty.
D000328:Adult; D000568:Amenorrhea / Q000150:complications / Q000209:etiology; D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D005687:Galactorrhea / Q000150:complications / Q000209:etiology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D013962:Thyroid (USP) / Q000627:therapeutic use*; D013963:Thyroid Hormones / Q000627:therapeutic use*
D013962:Thyroid (USP); D013963:Thyroid Hormones; D001971:Bromocriptine