HLA-linked susceptibility gene of Takayasu Disease.
The HLA-A, B, DR and MB antigens were investigated in patients suffering from Takayasu disease (Aortitis syndrome). Out of twenty-one HLA-A and B antigens tested, only HLA-Bw52 was significantly deviated (30147, PF = 63.8%, RR = 7.8) from the controls (14/76, PF = 18.4%). Since in the Japanese, HLA-Bw52 is in positive linkage disequilibria with HLA-DR2 and MB1, the association of the DR2 and MB1 antigens with Takayasu disease was studied. The HLA-DR2 antigen was significantly increased (23/30, PF = 76.7%,, RR = 6.0) in patients compared with the control (18/51, PF = 35.3%). Moreover, an almost perfect association of MBI (29/30, PF = 96.7%, RR = 12.6) with Takayasu disease was demonstrated. This finding supports the hypothesis that the genes in the HLA-D region play a major role in determining the susceptibility to Takayasu disease.
D001015:Aortic Arch Syndromes / Q000235:genetics*; D001327:Autoimmune Diseases / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D007564:Japan; D011863:Radioimmunoassay; D013625:Takayasu Arteritis / Q000453:epidemiology / Q000235:genetics*
D006680:HLA Antigens; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II