Inhibition of the glutamate uptake in the excitatory neuromuscular synapse of the locust by delta-philanthotoxin; a component of the venom of the solitary wasp Philanthus triangulum F. A high resolution autoradiographic study.
Glutamate uptake in insect neuromuscular junctions is inhibited by delta-philanthotoxin. Two other components of the philanthus venom (beta- and gamma-philanthotoxin) do not affect this glutamate uptake. No synergism between the active delta-philanthotoxin and the two inactive components had to be assumed to explain the inhibition by the Philanthus venom.
D000818:Animals; D001345:Autoradiography; D001514:Bee Venoms / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006110:Grasshoppers / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism*; D011073:Polyamines; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*; D014862:Wasp Venoms / Q000494:pharmacology*
D001514:Bee Venoms; D005971:Glutamates; D011073:Polyamines; D014862:Wasp Venoms; D018698:Glutamic Acid; C034092:delta-philanthotoxin