The influence of drugs on the response of a cell culture preparation to bacterial toxins.
The influence was studied of lanthanum chloride, chlorpromazine hydrochloride, indomethacin and sodium cromoglycate on the morphological changes induced in Vero cells by the action of the cholera toxin, the thermolabile enterotoxin (LT) and the Vero cell cytotoxin (VT) of Escherichia coli, the enterotoxin of Clostridium perfringens, and the cytotoxin of Clostridium difficile. These drugs were able to inhibit the effects produced by C. difficile cytotoxin but not by the other toxins examined.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D002746:Chlorpromazine / Q000494:pharmacology; D002772:Cholera Toxin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology; D003603:Cytotoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004357:Drug Synergism; D004768:Enterotoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D029968:Escherichia coli Proteins; D006162:Guanylate Cyclase / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney; D007811:Lanthanum / Q000494:pharmacology; D009712:Nucleotides, Cyclic / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D022622:Shiga Toxin 1
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D002147:Calmodulin; D003603:Cytotoxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D022622:Shiga Toxin 1; C035598:enterotoxin, Clostridium; C031815:toxB protein, Clostridium difficile; C028521:lanthanum chloride; D007811:Lanthanum; D002772:Cholera Toxin; C027538:heat-labile enterotoxin, E coli; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D004205:Cromolyn Sodium; D002118:Calcium; D002746:Chlorpromazine; D007213:Indomethacin