The nuclear localization of a putative neurotransmitter receptor.
A high affinity strychnine binding site has been identified within a membrane fraction prepared from partially purified rat brain nuclei. This interaction appears similar in its characteristics to that occurring in the non-nuclear membrane fraction which is thought to occur at the synaptic glycine receptor complex. Both the nuclear and non-nuclear membrane binding of tritiated strychnine is greater within the pons-medulla region than in the cerebral cortex. Nuclear membrane binding sites for dopamine, norepinephrine (beta-adrenergic), acetylcholine (muscarinic), GABA, and diazepam were not detected.
D000818:Animals; D001921:Brain / Q000378:metabolism; D008024:Ligands / Q000032:analysis / Q000378:metabolism; D008297:Male; D018377:Neurotransmitter Agents / Q000032:analysis; D009685:Nuclear Envelope / Q000032:analysis / Q000648:ultrastructure; D051381:Rats; D011916:Rats, Inbred F344; D011956:Receptors, Cell Surface / Q000032:analysis / Q000378:metabolism; D011955:Receptors, Drug / Q000032:analysis* / Q000378:metabolism; D018009:Receptors, Glycine; D013569:Synapses / Q000032:analysis / Q000378:metabolism
D008024:Ligands; D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface; D011955:Receptors, Drug; D018009:Receptors, Glycine; C027822:strychnine receptor