Gamma-glutamyl transpeptidase activity in human urine.
The gamma-glutamyl transpeptidase (EC 2.3.2.2) activity of the urine was determined in 369 cases, with L-gamma-glutamyl-p-nitranilide as substrate. Thermally stable, low molecular mass inhibitors were removed by dialysis. The enzyme activity was found to have a mean of 10.57 U/l for the normal neonate population, and a mean of 16.92 U/l for children. A significant increase in activity was observed in pyelonephritis, Alport's syndrome, Wilms' tumour and glomerulopathies. The highest activities were found in kidney diseases associated with renal insufficiency. This non-invasive test can be used for the evaluation of tubular disorders in childhood.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000652:urine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000652:urine*; D007680:Kidney Neoplasms / Q000652:urine; D008297:Male; D009394:Nephritis, Hereditary / Q000652:urine; D011704:Pyelonephritis / Q000652:urine; D012016:Reference Values; D009396:Wilms Tumor / Q000652:urine; D005723:gamma-Glutamyltransferase / Q000652:urine*
D005723:gamma-Glutamyltransferase