title: Wearable artificial endocrine pancrease with needle-type glucose sensor.
abstract: Miniaturisation of the bedside artificial endocrine pancreas in necessary to provide a means of restoring physiological glycaemic excursions in diabetic patients in the long term. One of the remaining problems in producing such a sophisticated device is the difficulty in developing a sufficiently small glucose-monitoring system. A needle-type glucose sensor has been developed which is suitable for use in a closed-loop glycaemic control system. The wearable artificial endocrine pancreas, incorporating the needle-type glucose sensor, a computer calculating infusion rates of insulin, glucagon, or both, and infusion pumps, was tested in pancreatectomised dogs: the device produced perfect control of blood glucose for up to 7 days.
mesh_terms: D000818:Animals; D001786:Blood Glucose; D004285:Dogs; D004566:Electrodes; D005934:Glucagon / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage; D007003:Hypoglycemia / Q000517:prevention & control; D007332:Insulin Infusion Systems; D008838:Microcomputers; D009339:Needles
chemical_list: D001786:Blood Glucose; D005934:Glucagon; D005947:Glucose