title: [The influence of persistent crowding on the spontaneous motor activity of the aging rat (author's transl)].
abstract: In the course of a long-term cohort study of stress and aging, the spontaneous activity of 169 male Sprague-Dawley rats was measured at various ages from 9 to 30 months. 84 animals were submitted to crowding from the age of 5 months onwards by housing them in groups of 12 per Makrolon-IV cage. 85 rats, kept as usual in groups of 6 per makrolon-IV cage, served as a control. Spontaneous activity was assessed by an electronic instrument (Animex Activity Meter), which also enabled us to distinguish between total and large movements. During senescence, the spontaneous activity of the control animals decreased slightly by approximately 20% after the age of 18 months. In addition to the quantitative change, a progressive flattening of the activity rhythm was observed. The animals kept under crowded conditions did not reveal any age-related decrease in spontaneous activity. At an advanced age, this resulted in significantly higher activity values in the crowded group as compared with the controls. The differences appeared even earlier and seemed to be more pronounced in the number of large movements. However, the progressive disappearance of the endogenous rhythm was apparent in both the crowded and the control group. It can be concluded that at least two types of change in the central nervous system may be responsible for the aging-changes in spontaneous activity: one which disintegrates the "time structure" of the organism, and a second one which affects motivational centers. Crowded conditions seem to improve the latter, whereas they have no effect on the aging of the "biological clock".
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D001522:Behavior, Animal; D003441:Crowding; D008297:Male; D009043:Motor Activity; D051381:Rats
vernacular_title: Der Einfluss anhaltend erhöhtr Populationsdichte auf die Spontanaktivität der alternden Ratte.