Absorption of beta-adrenoceptor antagonists to Amberlite resin.
The adsorption of beta-adrenoceptor blockers and the partial beta-adrenoceptor agonist prenalterol was studied in an in vitro haemoperfusion (HP) model. Metoprolol, alprenolol, propranolol and prenalterol adsorb well from the blood to the resin with extraction ratios nearing 1.0. Extraction ratio for practolol was 0.68 and for atenolol 0.49. Protein binding has little effect on the degree of adsorption, which is more dependent on water solubility.
D000317:Adrenergic alpha-Antagonists; D000327:Adsorption; D000526:Alprenolol; D006464:Hemoperfusion; D006801:Humans; D066298:In Vitro Techniques; D007475:Ion Exchange Resins; D008790:Metoprolol; D011217:Practolol / Q000031:analogs & derivatives; D011294:Prenalterol
D000317:Adrenergic alpha-Antagonists; D007475:Ion Exchange Resins; D000526:Alprenolol; D008790:Metoprolol; D011294:Prenalterol; D011217:Practolol