title: Lorazepam premedication for labour.
abstract: Fifty primigravidae were given either lorazepam (2 mg) or identical dummy tablets in early labour, in a randomized double-blind fashion. Analgesia (standardized at pethidine 100 mg) was given as required, and pain relief was assessed by visual analogue scale. Analgesia was significantly better in those mothers who had received lorazepam. There was a higher incidence of respiratory depression at birth in the infants in this group, although this was not statistically significant. Patients given lorazepam were all satisfied with their analgesic regimen compared with half of those given an inactive tablet. There was a higher incidence of amnesia for labour in the active group. There is a need for a similar study of the effects of other drugs which are given to supplement pethidine in labour.
mesh_terms: D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D008140:Lorazepam / Q000627:therapeutic use*; D008431:Maternal-Fetal Exchange; D008614:Meperidine / Q000627:therapeutic use; D011247:Pregnancy; D011292:Premedication; D011897:Random Allocation
chemical_list: D014151:Anti-Anxiety Agents; D008614:Meperidine; D008140:Lorazepam