title: Central nervous system sites of action of bombesin and somatostatin to influence plasma epinephrine levels.
abstract: Bombesin acts within dog brain to increase plasma concentrations of glucose and epinephrine. Microinjection of bombesin into a variety of brain regions demonstrates that this peptide's site of action is within the dorsal hypothalamic area. Microinjection of the somatostatin analog, desAA1,2,4,5,12,13 [D-Trp8]-somatostatin (ODT8-SS) into the dorsal hypothalamic area but not into other brain areas prevents bombesin-induced elevation of plasma glucose and epinephrine. Thus bombesin and ODT8-SS act within specific brain areas to influence plasma concentrations of glucose and epinephrine.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001839:Bombesin / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D001931:Brain Mapping; D004285:Dogs; D004837:Epinephrine / Q000097:blood*; D007034:Hypothalamus, Posterior / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D013004:Somatostatin / Q000494:pharmacology* / Q000031:analogs & derivatives
chemical_list: D001786:Blood Glucose; D010446:Peptide Fragments; D010455:Peptides; D013004:Somatostatin; C017583:somatostatin, octapeptide-Trp(8)-; D001839:Bombesin; D004837:Epinephrine