Organophosphate inhibition of avian salt gland Na, K-ATPase activity.
1. Adult black ducks (Anas rubripes) were given freshwater or saltwater (1.5% NaCl) for 11 days and half of each group was also given an organophosphate (17 p.p.m. fenthion) in the diet on days 6-11. 2. After 11 days, ducks drinking saltwater had lost more weight and had higher plasma Na and uric acid concentrations and osmolalities than birds drinking freshwater. 3. Saltwater treatment stimulated the salt gland to increased weight and Na, K-ATPase activity. 4. Fenthion generally reduced plasma and brain cholinesterase activity and depressed cholinesterase and Na, K-ATPase activities in salt glands of birds drinking saltwater.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004372:Ducks / Q000378:metabolism*; D005284:Fenthion / Q000494:pharmacology; D006400:Hematocrit; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D012491:Salt Gland / Q000201:enzymology*; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D009943:Organophosphorus Compounds; D012964:Sodium; D005284:Fenthion; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium