[Effect of ranitidine on secretion of gastric intrinsic factor and absorption of vitamin B 12].
The effects of ranitidine, a new potent histamine H2-receptor antagonist, on gastric intrinsic factor (IF) secretion and protein-bound cobalamin absorption were evaluated in 6 patients with duodenal ulcer, before, during and after discontinuation of ranitidine therapy. Oral ranitidine (150 mg twice a day) resulted in a non significant decrease of IF concentration and IF output but was responsible for malabsorption of protein-bound cobalamin. This malabsorption was reversible upon discontinuation of ranitidine. These results indicate that occurrence of cobalamin deficiency cannot be excluded during long-term ranitidine treatment and emphasize the need for careful follow-up in these patients.
D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000188:drug therapy; D005663:Furans / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007437:Intrinsic Factor / Q000378:metabolism*; D008875:Middle Aged; D011899:Ranitidine; D014805:Vitamin B 12 / Q000378:metabolism*
D000897:Anti-Ulcer Agents; D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D007437:Intrinsic Factor; D014805:Vitamin B 12
Effet de la ranitidine sur la sécrétion de facteur intrinsèque gastrique et sur l'absorption de la vitamine B12.