Determination of the alpha, beta-adrenoceptor blocker YM-09538 in urine by gas chromatography with a nitrogen-sensitive detector.
A gas chromatographic method for the quantitative determination of the alpha, beta-adrenoceptor blocker YM-09538 in urine is described. YM-09538 was extracted from alkalinized urine with ethyl acetate and converted to its cyclic methylboronate derivative. Analysis by gas chromatography using a nitrogen-sensitive detector allowed quantitation of the drug over a concentration range of 0.2-5.0 micrograms/ml. Urinary excretion of YM-09538 was determined in humans after oral administration of 50 mg.
D000317:Adrenergic alpha-Antagonists / Q000652:urine*; D000319:Adrenergic beta-Antagonists / Q000652:urine*; D000328:Adult; D002849:Chromatography, Gas / Q000379:methods; D004983:Ethanolamines / Q000652:urine*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008832:Microchemistry; D009584:Nitrogen; D000096926:Benzenesulfonamides
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D009584:Nitrogen; C032473:amosulalol; D000096926:Benzenesulfonamides