[Effect of narcotic analgesics of nociceptive transmission in the spinal cord].
The action of morphine, promedol, fentanyl and pentazocin on nociceptive transmission in the spinal cord was studied in unanesthetized spinal rats with the use of intraarterial injection of bradykinin. When used in the same doses, the opiates also reduced the firing of the axons of the ascending portions of the spinal cord. Naloxon rapidly antagonized the action of the narcotics.
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors; D005283:Fentanyl / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D010423:Pentazocine / Q000494:pharmacology; D011396:Promedol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D000701:Analgesics, Opioid; D011396:Promedol; D009020:Morphine; D010423:Pentazocine; D001920:Bradykinin; D005283:Fentanyl
O vliianii narkoticheskikh anal'getikov na peredachu notsitseptivnogo vozbuzhdeniia v spinnom mozge.