[Seasonal changes in the gamma-aminobutyric acid system of the mouse brain].
Dynamics of gamma-aminobutyric acid (GABA) content, the level of glutamate and total content of dicarboxylic amino acids and their amides as well as glutamate decarboxylase and GABA-alpha-ketoglutarate aminotransferase activities in the brain of F1CBAXC57BL/6 hybrid mice were determined during a year. The content of GABA and adicarboxylic acids in the brain in autumn-winter is higher than in summer. An analogous regularity is observed in the activity of basic enzymes of the GABA metabolism. Against a background of the common regularity (higher values of these indices in winter and autumn and comparatively low in summer) a particularly pronounced significant increase (as compared with the minimum level) is found in March for the activity of GABA-shunt enzymes, the content of GABA and dicarboxylic amino acids. The data obtained testify to the fact that in autumn-winter the brain tissue is characterized by a comparatively high content of dicarboxylic amino acids, their amides and GABA as well as by a more intensive functioning of the GABA-shunt, which is confirmed by the activation of the enzymes of GABA production and utilization in the corresponding seasons.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000600:Amino Acids, Dicarboxylic / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008297:Male; D051379:Mice; D012621:Seasons; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000600:Amino Acids, Dicarboxylic; D005971:Glutamates; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase
Sezonnye izmeneniia v sisteme gamma-aminomaslianoĭ kisloty golovnogo mozga mysheĭ.