[Development of tolerance to haloperidol in the rat striatum].
Microiontophoretic application of dopamine effects in the rat's striatum a dose-dependent inhibition of the glutamate-induced pulse activities. Acute systemic applications of haloperidol are able to abolish this dopamine-induced inhibition. After chronic pretreatment with haloperidol, however, acute administration of haloperidol can no longer antagonize the dopamine-induced inhibition of the pulse activity. Hence, it is likely that tolerance to haloperidol , as described in individual behavioral studies can develop also on the cellular level.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006220:Haloperidol / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D018698:Glutamic Acid; D006220:Haloperidol; D004298:Dopamine
Toleranzentwicklung gegenüber Haloperidol im Striatum der Ratte.