title: Double-blind controlled crossover trial of 4% intranasal sodium cromoglycate solution in patients with seasonal allergic rhinitis.
abstract: In a double-blind, controlled, crossover study involving 47 subjects documented with seasonal allergic rhinitis, repeated intranasal administration of 4% sodium cromoglycate solution was associated with significant reduction in symptoms and decrease in consumption of antihistaminic drugs. Side effects were mild and transitory. It is concluded that intranasal sodium cromoglycate administration is an efficacious preventive and therapeutic approach in the management of patients with seasonal allergic rhinitis.
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D006634:Histamine H1 Antagonists; D004205:Cromolyn Sodium