[Antihistaminic effect of a hydrogel with the components diphenhydramine, N,N-diethyl-m-toluamide and phthalic acid dimethyl ester].
The combination of the antihistamine diphenhydramine as well as the repellents N,N-diethyl-m-toluamide and dimethylphthalate as the active constituents of an insect repellent (Pellit) guarantees a remarkable antihistaminic effect. Surprisingly the repellent N,N-diethyl-m-toluamide proved itself to be an antihistamine. The UV-erythema model was used on the dorsal skin of male volunteers.
D000328:Adult; D001549:Benzamides / Q000494:pharmacology*; D003671:DEET / Q000494:pharmacology*; D004155:Diphenhydramine / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D004890:Erythema / Q000517:prevention & control; D005782:Gels; D006634:Histamine H1 Antagonists; D006801:Humans; D007302:Insect Repellents / Q000494:pharmacology*; D008297:Male; D010795:Phthalic Acids / Q000494:pharmacology*; D012882:Skin Tests; D013997:Time Factors
D001549:Benzamides; D004338:Drug Combinations; D005782:Gels; D006634:Histamine H1 Antagonists; D007302:Insect Repellents; D010795:Phthalic Acids; D003671:DEET; C037306:Pellit; D004155:Diphenhydramine
Uber den Antihistamin-Effekt eines Hydrogels mit den Komponenten Diphenhydramin, N,N-Diethyl-m-toluamid und Phthalsäuredimethylester.