The involvement of 5-hydroxytryptamine in the release of dendritic dopamine from slices of rat substantia nigra.
[3H]dopamine (DA) accumulated by slices of rat substantia nigra was released following superfusion with Krebs solution containing 5-hydroxytryptamine (5-HT) in a dose-dependent fashion with maximal release being produced by 1 X 10(-4) M. This 5-HT-induced release of [3H]DA was calcium-dependent and was inhibited by pretreatment with the 5-HT antagonist cinanserin. These results are interpreted as supporting the possibility that 5-HT has a role in regulating dopaminergic activity in the nigro-striatal pathway.
D000818:Animals; D002118:Calcium / Q000502:physiology; D002928:Cinanserin / Q000494:pharmacology; D003712:Dendrites / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013378:Substantia Nigra / Q000378:metabolism*; D013997:Time Factors
D012701:Serotonin; D002928:Cinanserin; D002118:Calcium; D004298:Dopamine