title: Binding of [3H]ADTN to rat striatal membranes.
abstract: The conformationally restricted dopamine analogue ADTN binds in a specific saturable manner to rat striatal membranes. Analysis of the data suggests a single binding site. Binding of [3H]ADTN is displaced by a wide range of dopamine agonists and antagonists (both typical and atypical). The potency of ADTN derivatives to displace [3H]ADTN correlates well with their activity as agonists in other tests both in vivo and in vitro.
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism; D001667:Binding, Competitive; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology*; D004876:Ergot Alkaloids / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008566:Membranes / Q000378:metabolism; D009281:Naphthalenes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013764:Tetrahydronaphthalenes / Q000378:metabolism*
chemical_list: D014150:Antipsychotic Agents; D004876:Ergot Alkaloids; D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; C011639:ADTN; D004298:Dopamine