Modification of the haemoglobin oxygen dissociation curve in whole blood by a compound with dual action.
2-Ethoxy-6-(5-tetrazolyl)xanthone reduces the oxygen affinity of blood by two mechanisms; firstly, by a direct effect on the haemoglobin molecule and secondly by maintaining levels of 2,3-diphosphoglycerate (DPG) in stored blood. This compound thus has potential as a blood storage additive which will improve the oxygen delivery of stored blood.
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000097:blood; D001793:Blood Preservation; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood*; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D014966:Xanthenes; D044004:Xanthones; D019794:2,3-Diphosphoglycerate; C041880:2-ethoxy-6(5-tetrazolyl)xanthone; D000255:Adenosine Triphosphate; D010100:Oxygen