Pharmacodynamics of vecuronium and pancuronium in cats with and without ligated renal pedicles.
The pharmacodynamic behaviour upon continuous infusion and bolus administration of pancuronium and vecuronium was studied in cats with and without ligated renal pedicles. In all circumstances vecuronium had a shorter time course of action than pancuronium. Ligation of the renal pedicles, i.e. acute renal failure, did not significantly influence the time course of the respective neuromuscular blockades. It is suggested that uptake by aspecific binding sites of the compounds is the main determining factor in termination of the blockade. A difference between acute and chronic renal failure is expected to exist.
D058186:Acute Kidney Injury / Q000378:metabolism*; D000771:Anesthesia, Intravenous; D000818:Animals; D002415:Cats; D005260:Female; D006207:Half-Life; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D009466:Neuromuscular Blocking Agents / Q000378:metabolism*; D010197:Pancuronium / Q000031:analogs & derivatives* / Q000378:metabolism*; D014403:Tubocurarine / Q000378:metabolism; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium; D014403:Tubocurarine