[Racemic guanidinothiazoles with H2-antihistaminic activity. 13 H2-antihistaminics].
In studies on H2-antihistaminics with cyclic guanidine structure, side-chain branched racemic guanidinothiazoles were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium. A simple synthesis of alpha-branched guanidinothiazoles is described. Of the prepared substances the racemic 14a, b in particular show high H2-antagonistic activity.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D006146:Guanidines; D006635:Histamine H2 Antagonists; D013844:Thiazoles
Razemische Guanidinothiazole mit H2-antihistaminischer Wirkung. 13. Mitt.: H2-Antihistaminika.