[Effect of somatostatin on gastric hydrochloric acid secretion and serum gastrin concentration in the dog].
I.v. administration of somatostatin (1.5 micrograms/kg/g) reduced the gastric secretion induced by pentagastrin and histamine. Microapplication of somatostatin to globus pallidus (10 micrograms in 3 ml) increased the acid secretion in the dog stomach. The serum gastrin level was decreased both in the i.v. administration of somatostatin and in its cerebral application.
D000818:Animals; D001931:Brain Mapping; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D005917:Globus Pallidus / Q000187:drug effects*; D006632:Histamine / Q000008:administration & dosage; D007275:Injections, Intravenous; D008845:Microinjections; D010418:Pentagastrin / Q000008:administration & dosage; D013004:Somatostatin / Q000008:administration & dosage*
D005755:Gastrins; D013004:Somatostatin; D006632:Histamine; D010418:Pentagastrin
Vliianie somatostatina na sekretsiiu gidrokhloristoĭ kisloty zheludkom sobak i na kontsentratsiiu gastrina syvorotki krovi.