title: [Gamma-glutamyltransferase in maternal serum and prenatal screening for the fetal alcohol syndrome].
abstract: In order to investigate prospectively in pregnant women a correlation between serum levels of a biological marker of alcohol and the clinical status of the newborn, we measured the gamma-glutamyltransferase (GGT) in 630 women between 14 and 20 weeks of pregnancy. In 7% of the cases, an elevated value was observed while history confirmed alcohol consumption in only 1%. Preliminary statistical analysis established upon the blind examination of 308 newborns show a correlation between maternal GGT levels and birthweight as well as the pre- and perinatal complications. However, the sensitivity of this test is weak.
mesh_terms: D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000201:enzymology*; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011296:Prenatal Diagnosis / Q000379:methods*; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase
vernacular_title: Gamma-glutamyltransférase sérique maternelle et dépistage prénatal du syndrome de l'alcoolisme foetal.