title: Migraine is a food-allergic disease.
abstract: Foods which provoked migraine in 9 patients with severe migraine refractory to drug therapy were identified. The patients were then given either sodium cromoglycate or placebo orally in a double-blind manner, with foods previously identified as provocants. Sodium cromoglycate exerted a protective effect, thus confirming that it can prevent a hypersensitivity mechanism as well as the symptoms of migraine. Immune complexes were not produced in those patients who were protected by sodium cromoglycate. These observations confirm that a food-allergic reaction is the cause of migraine in this group of patients.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D011897:Random Allocation; D012882:Skin Tests
chemical_list: D000936:Antigen-Antibody Complex; D007073:Immunoglobulin E; D004205:Cromolyn Sodium