title: [Clinico-chemical diagnosis of the cholestasis syndrome].
abstract: 1. Cholestatic reactions of various etiology are biochemically established by determination of alkaline phosphatase, gamma-glutamyltranspeptidase (and leucinaminopeptidase) activities and of bile acid concentrations in serum. 2. The pathomechanisms of elevated serum activities of AP, gamma-GT and LAP in cholestatic diseases are - an induction of these canalicular membrane bound enzymes, probably due to an intracellular increase of bile acids, - a partial solubilization of canalicular membrane structure (detergent effect of bile acids), - a histochemically and morphologically demonstrable change of liver cell polarity. 3. A discrimination of intra- or extrahepatic cholestasis only by means of biochemical parameters is impossible. 4. Additional serological and immunological parameters often demonstrate the etiology of cholestatic diseases; a short review is given.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D001647:Bile Acids and Salts / Q000097:blood; D001663:Bilirubin / Q000378:metabolism; D002570:Ceruloplasmin / Q000097:blood; D002779:Cholestasis / Q000175:diagnosis*; D003300:Copper / Q000097:blood; D003937:Diagnosis, Differential; D006525:Hepatitis, Viral, Human / Q000175:diagnosis; D006527:Hepatolenticular Degeneration / Q000175:diagnosis; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008103:Liver Cirrhosis / Q000175:diagnosis; D008113:Liver Neoplasms / Q000175:diagnosis; D013577:Syndrome; D000637:Transaminases / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D003300:Copper; D002570:Ceruloplasmin; D005723:gamma-Glutamyltransferase; D000637:Transaminases; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase; D001663:Bilirubin
vernacular_title: Klinisch-chemische Diagnostik des Cholestase-Syndroms.