Severe pulmonary hypersensitivity associated with passive transfusion of a neutrophil-specific antibody.
A life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia and transient hypocomplementaemia developed in a 73-year-old man after repair of an abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2) was demonstrated by granulocyte immunofluorescence and microagglutination in one of the transfused donor units. In addition, activated complement component C5a was generated in vitro by incubation of the patient's serum with the aortic graft material. This severe clinical reaction may have resulted from the interaction of the transfused anti-NA2 antibody with complement activation induced by the aortic graft material.
D000368:Aged; D000906:Antibodies / Q000032:analysis*; D001014:Aortic Aneurysm / Q000601:surgery; D001788:Blood Grouping and Crossmatching; D003167:Complement Activation; D003182:Complement C5 / Q000172:deficiency; D015936:Complement C5a; D006801:Humans; D007116:Immunization, Passive; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D009503:Neutropenia / Q000209:etiology; D009504:Neutrophils / Q000276:immunology*; D011654:Pulmonary Edema / Q000209:etiology; D012130:Respiratory Hypersensitivity / Q000209:etiology*; D065227:Transfusion Reaction
D000906:Antibodies; D003182:Complement C5; D015936:Complement C5a