In vivo inhibition of phospholipase A2 in rat lung by an beta-adrenergic agonist.
Phospholipase A2 is the key enzyme for the release of arachidonic acid derived mediators via cycloxygenase or lipoxygenase pathways in inflammation and immunological processes. Activity of microsomal phospholipase A2 in rat lung can be inhibited by in vivo application of the beta-adrenergic drug fenoterol both in control and diseased animals.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D008168:Lung / Q000201:enzymology*; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D051381:Rats
D000318:Adrenergic beta-Agonists; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2