In vivo effect of mercuric chloride on tissue ATPases of Notopterus notopterus.
Effect of sublethal concentrations, 0.088, 0.044, 0.029, 0.022 and 0.0176 mg HgCl2 per liter (1/5, 1/10, 1/15, 1/20, and 1/25 fractions of 96-h LC50) on Na+-K+, Mg2+, and total ATPase activities in brain, gills, kidney and liver of Notopterus notopterus have been studied after 30 days exposure. Na+-K+ ATPase were inhibited maximally and significantly in brain and minimally and insignificantly in liver. Mg2+ ATPase was inhibited maximally and significantly (P less than 0.01) in brain and minimally and insignificantly in kidney. The relative inhibition of total, Na+-K+ and Mg2+ ATPases for the tissues studied were brain greater than gill greater than kidney greater than liver. At the concentration (1/25 fraction) the enzyme activity returned to the normal range.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000201:enzymology; D017301:Ca(2+) Mg(2+)-ATPase; D005399:Fishes / Q000378:metabolism*; D005880:Gills / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008627:Mercuric Chloride; D008628:Mercury / Q000633:toxicity*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D008627:Mercuric Chloride; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D008628:Mercury