[Effect of central adrenergic alpha receptor blockader IEM-611 on the activity of alcohol and aldehyde dehydrogenase in rat liver].
The effect of IEM-611 (30 mg/kg) on alcohol consumption in rats under the conditions of voluntary choice between water and 15% ethanol was studied as that on alcohol dehydrogenase (ADH) in postmitochondrial supernatant and in NAD-dependent aldehyde dehydrogenases (A1DH) in liver mitochondria. Administration of IEM-611 during 6 or 12 days reduces ethanol consumption by 29 and 30%, respectively, activates ADH and appreciably decreases overall activity of NAD-dependent A1DH. At the same time the ADH/A1DH ratio increases. Activation of ADH and A1DH and the decreased ADH/A1DH ratio were disclosed in alcohol preferring rats as compared to water preferring animals. IEM-611 shifts enzymatic activity of ethanol metabolism towards the level characteristic for water preferring rats. It is suggested that variation of the ADH/A1DH ratio is one of the mechanisms responsible for the decreased ethanol consumption in rats.
D000317:Adrenergic alpha-Antagonists; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism / Q000523:psychology; D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000818:Animals; D044482:Benzeneacetamides; D002755:Choice Behavior; D004789:Enzyme Activation; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D044482:Benzeneacetamides; D010627:Phenethylamines; C022075:IEM 611; D000429:Alcohol Oxidoreductases; D000445:Aldehyde Oxidoreductases
Vliianie tsentral'nogo alpha-adrenoblokatora IEM-611 na aktivnost' alkogol'- i al'degiddegidrogenaz v pecheni krys.