Pre-operative ranitidine. Effect of a single intravenous dose on pH and volume of gastric aspirate.
Ninety-four patients undergoing elective surgery received ranitidine 100 mg or 50 mg intravenously one hour pre-operatively, or acted as controls. A gastric aspirate pH in excess of 2.5 one to two hours after administration was achieved in 93% of patients given 100 mg, 88% of those given 50 mg, and 61% of controls. There were no significant differences in the volumes of gastric aspirate.
D000328:Adult; D005260:Female; D005663:Furans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005750:Gastric Juice / Q000187:drug effects*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011899:Ranitidine; D013514:Surgical Procedures, Operative; D013997:Time Factors
D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine