Possible involvement of glutamate in electrocortical activity.
Microinjections of the excitatory amino acid L-glutamic acid into the mesencephalic reticular formation lead to activation or desynchronization of the electrocorticogram, whereas its topical application to the exposed cortex induces an increase in the amplitude of electrocortical activity. The results indicate that L-glutamic acid may well be involved directly or indirectly with transmission of reticular cell populations related to the control of electrocortical activity and may also act directly on the cortical neurones.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004553:Electric Conductivity; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D012154:Reticular Formation / Q000187:drug effects / Q000502:physiology*
D005971:Glutamates; D018698:Glutamic Acid