Reversal of clonidine induced miosis by the alpha 2-adrenoreceptor antagonist RX 781094.
Clonidine given i.v. at a dose of 0.1 mg and 0.2 mg was found to cause miosis in a placebo controlled double-blind study in six healthy volunteers. In a further single-blind placebo controlled study in three of these volunteers, the alpha 2-adrenoreceptor antagonist RX 781094 at a dose of 0.1 mg/kg i.v. reversed the miosis induced by i.v. clonidine 0.2 mg. At a dose of 0.05 mg/kg the miosis was partially reversed.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D003000:Clonidine / Q000037:antagonists & inhibitors*; D004147:Dioxins / Q000494:pharmacology*; D006801:Humans; D019329:Idazoxan; D011680:Pupil / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D004147:Dioxins; D003000:Clonidine; D019329:Idazoxan