Ammonium chloride and chloroquine inhibit rabies virus infection in neuroblastoma cells. Brief report.
Two lysosomotropic agents, ammonium chloride and chloroquine inhibit the infection of murine neuroblastoma cells by rabies virus. The experiments indicate that rabies virus infects the neuronal cells through an endosome pH dependent entry pathway.
D000643:Ammonium Chloride / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology*; D004705:Endocytosis; D011992:Endosomes / Q000502:physiology; D008247:Lysosomes / Q000187:drug effects; D051379:Mice; D009447:Neuroblastoma; D009474:Neurons / Q000382:microbiology*; D011820:Rabies virus / Q000254:growth & development*; D014779:Virus Replication / Q000187:drug effects
D000643:Ammonium Chloride; D002738:Chloroquine