Ranitidine influences the uptake of oral midazolam.
In a randomised crossover study in volunteers plasma midazolam levels were estimated for 24 h following 15 mg by mouth, either preceded by no medication or following 24 h therapy with ranitidine. Administration of the H2-receptor blocker significantly increased bioavailability of the benzodiazepine and resulted in higher plasma levels for the first 6 h after taking midazolam. This was accompanied by a greater soporific effect.
D001569:Benzodiazepines / Q000378:metabolism*; D001682:Biological Availability; D004347:Drug Interactions; D005663:Furans / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008874:Midazolam; D011899:Ranitidine; D013997:Time Factors
D005663:Furans; D006635:Histamine H2 Antagonists; D001569:Benzodiazepines; D011899:Ranitidine; D008874:Midazolam