Beta-adrenoceptor stimulants and mesovarian leiomyomas in the rat.
The experiment reported here shows that mesovarian leiomyomas may be induced in rats by the administration of 2 chemically distinct adrenergic stimulants, salbutamol or terbutaline. That the induction of these benign tumours is a function of adrenergic stimulation is shown by the fact that the concurrent administration of the adrenergic blocker propranolol prevented their development.
D000290:Adnexa Uteri / Q000187:drug effects*; D000318:Adrenergic beta-Agonists / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000420:Albuterol / Q000097:blood / Q000633:toxicity; D000818:Animals; D001956:Broad Ligament / Q000187:drug effects*; D005260:Female; D005833:Genital Neoplasms, Female / Q000139:chemically induced*; D007889:Leiomyoma / Q000139:chemically induced*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013726:Terbutaline / Q000097:blood / Q000633:toxicity
D000318:Adrenergic beta-Agonists; D011433:Propranolol; D013726:Terbutaline; D000420:Albuterol