The fibrinolytic activity of cerebrospinal fluid after subarachnoid hemorrhage.
Fibrinolytic activity of cerebrospinal fluid and peripheral blood was studied in 14 patients with subarachnoid hemorrhage during the high-risk period of subarachnoid rebleeding. Fibrinolytic activity of cerebrospinal fluid or peripheral blood could not be demonstrated. Determination of fibrin degradation products showed high levels in cerebrospinal fluid, being a result of meningeal irritation. The findings in this study--as well as other observations--suggest, that antifibrinolytic therapy should not be administered in patients with subarachnoid hemorrhage.
D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D005338:Fibrin Fibrinogen Degradation Products / Q000134:cerebrospinal fluid; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D002532:Intracranial Aneurysm / Q000134:cerebrospinal fluid; D007700:Kinetics; D011379:Prognosis; D012008:Recurrence; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000188:drug therapy
D000933:Antifibrinolytic Agents; D005338:Fibrin Fibrinogen Degradation Products