Comparative study of lorazepam and trimeprazine for oral premedication in paediatric anaesthesia.
One hundred and ninety-nine children received lorazepam 0.05 mg kg-1 or trimeprazine 3 mg kg-1 as oral premedication in a double-blind trial. Lorazepam proved more palatable and produced a cheerful demeanour, but possessed no significant advantages on overall assessment before surgery. Following operation, restlessness with vomiting, and evidence of retrograde amnesia occurred more frequently with lorazepam.
D000284:Administration, Oral; D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D002675:Child, Preschool; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D011229:Preanesthetic Medication; D014291:Trimeprazine / Q000008:administration & dosage / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D014291:Trimeprazine; D008140:Lorazepam