Memory enhancement induced in chicks by L-prolyl-L-leucyl-glycinamide.
Two-day-old chicks were injected either intraventricularly or intraperitoneally with saline or a L-prolyl-L-leucyl-glycinamide solution. This C-terminal tripeptide of oxytocin produced retrograde enhancement when injected centrally but not peripherally. Possible memory mechanisms are discussed in light of this peptide's relationship to oxytocin, MSH, and dopaminergic systems.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D010121:Oxytocin / Q000494:pharmacology*; D012153:Retention, Psychology / Q000187:drug effects*; D013649:Taste / Q000187:drug effects
D010121:Oxytocin; D009075:MSH Release-Inhibiting Hormone