Development of three Thy 1 + cell populations induced by distinct thymic stromal elements.
Thymectomized, X-irradiated mice, reconstituted with T cell-deprived bone marrow, were treated for 10 weeks with various thymic stromal fractions. Their splenocytes were then assayed for Thy 1 antigen. Three Thy 1 + populations were identified: cells of population 1 were found in mice treated with a membrane extract of thymic stroma. They had a high Thy 1 concentration which could be reduced (Population 2) after incubation with a thymic hormone preparation (STF). Population 3 was also composed of high Thy 1 cells but these were induced by STF treatment in vivo and could not be further differentiated into low Thy 1 cells.
D000818:Animals; D000954:Antigens, Surface; D002454:Cell Differentiation / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011828:Radiation Chimera; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D018800:Thy-1 Antigens; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D013951:Thymus Hormones / Q000494:pharmacology
D000954:Antigens, Surface; D018800:Thy-1 Antigens; D013951:Thymus Hormones