title: Release of aspartate and glutamate caused by chloride reduction in synaptosomal incubation media.
abstract: Release of the amino acid neurotransmitter candidates aspartate and glutamate from synaptosomes can be stimulated by reduction of [Cl-] in the incubation medium by replacement with the impermeant anions propionate and isethionate. Replacement by the permeant anion Br- is without effect on amino acid release. This release offers a biochemical method of studying the Cl-ion channel in CNS membrane.
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D066298:In Vitro Techniques; D007700:Kinetics; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
chemical_list: D002712:Chlorides; D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid