Functional properties of catecholamine-sensitive adenylate cyclase system in embryonic chick skeletal muscle.
1. At the embryonic stages the adenylate cyclase of chick skeletal muscle possesses high catalytic activity, which is about 10 times higher than its mature level. 2. The reactivity of adenylate cyclase system to catecholamines appears in embryogenesis by the end of the second week, whereas the dose dependence only appears in the third week. 3. The stimulatory effect of catecholamines on adenylate cyclase in chick skeletal muscle is mediated through the beta-adrenoreceptor. 4. The suggestion is made that the limiting factor in the development of adrenoreactivity of membrane adenylate cyclase system is the number of receptors.
D000262:Adenylyl Cyclases / Q000502:physiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology*; D002642:Chick Embryo; D002645:Chickens; D000242:Cyclic AMP / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D009132:Muscles / Q000196:embryology / Q000201:enzymology*; D011433:Propranolol / Q000494:pharmacology; D013997:Time Factors
D002395:Catecholamines; D011433:Propranolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol