Hypouricaemic effect after oral administration in chickens of polyethylene glycol-modified uricase entrapped in liposomes.
Liposomal-entrapped methoxypolyethyleneglycol (PEG) modified uricase was used to study the plasma urate lowering effect after its oral administration to chickens. Plasma uric acid concentrations fell gradually and were accompanied by a rise in plasma uricolytic activity. Serum from chickens given PEG-modified uricase liposomes did not react with native uricase in immunodiffusion plates. These results suggested the clinical usefulness of liposome-entrapped PEG modified uricase in the treatment of hyperuricaemia.
D000818:Animals; D002645:Chickens; D005779:Immunodiffusion; D008081:Liposomes; D011092:Polyethylene Glycols / Q000494:pharmacology; D014503:Urate Oxidase / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood*
D008081:Liposomes; D014527:Uric Acid; D011092:Polyethylene Glycols; D014503:Urate Oxidase