title: [Treatment of undescended testis with IH-RH nasal spray].
abstract: 23 boys from one to 12 years old with 39 undescended testes were treated with LH-RH. This releasing hormone was administered in the form of a nasal spray six times a day. Irrespective of the body weight, the daily dose was 1.2 mg. The treatment was continued for a total of four weeks, even when success was already visible after two weeks. 16 testes reached the desired scrotal position. In addition, pendulous testes developed four times; five testes showed a partial descensus. Of twelve testes which did not alter their position in the craniocaudal direction, four were significantly better mobilizable than previously. Genital and extragenital side effects were rare. In this novel treatment principle, children are spared intramuscular injection (up to now with chorionic gonadotropin). According to available communications, the descensus rate is between 22 and 68% and is comparable to that after HCG therapy. With the release of LH and FSH, LH-RH imitates a physiological hormone phase and thereby leads to descensus. Accordingly, the side effects are less than after HCG. Taking into account the guidelines for treatment of maldescensus testis worked out by the National Health Foundation, this new therapy principle is to be recommended.
mesh_terms: D000336:Aerosols; D002648:Child; D002675:Child, Preschool; D003456:Cryptorchidism / Q000188:drug therapy*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D000336:Aerosols; D007987:Gonadotropin-Releasing Hormone
vernacular_title: Die Behandlung des Maldescensus testis mit LH-RH-Nasalspray.