NMR determination of isosorbide dinitrate and beta-adrenergic blocking agents in tablets.
An NMR spectroscopic method for the determination of isosorbide dinitrate, alone or together with alprenolol or propranolol, is described. Spectra are determined in dimethyl sulfoxide-d6 containing maleic acid or 1,4-dinitrobenzene as internal standards. Both synthetic mixtures and commercial formulations were assayed, and the results were compared using compendial procedures.
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D000526:Alprenolol / Q000032:analysis; D007548:Isosorbide Dinitrate / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D011433:Propranolol / Q000032:analysis; D013607:Tablets / Q000032:analysis
D000319:Adrenergic beta-Antagonists; D013607:Tablets; D000526:Alprenolol; D011433:Propranolol; D007548:Isosorbide Dinitrate