title: Glutamate uptake, glutamate decarboxylase and choline acetyltransferase in subcortical areas after sensorimotor cortical ablations in the cat.
abstract: High affinity glutamate uptake (HAGU), glutamate decarboxylase (GAD) and choline acetyltransferase (CAT) activities were measured from subcortical nuclei in the cat brain after ipsilateral ablation of the sensorimotor cortex. Results showed a drop in HAGU in all the structures assayed except the subthalamic nucleus. These changes in HAGU are generally accompanied by a decrease in GAD while CAT is unaffected. However, in the red nucleus the drop in HAGU is concomitant to an increase in GAD and CAT. In the subthalamic nucleus HAGU and CAT are increased while GAD is decreased. These results are consistent with the concept that most corticofugal fibres to subcortical structures use glutamate as their neurotransmitter. Results concerning GAD suggest that GABAergic subcortical neurons are under a cortical influence. This influence seems to be weak on cholinergic neurons.
mesh_terms: D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D002262:Carboxy-Lyases / Q000378:metabolism*; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D007839:Functional Laterality; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D009928:Organ Specificity
chemical_list: D005971:Glutamates; D018698:Glutamic Acid; D002795:Choline O-Acetyltransferase; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase