6-Hydroxydopamine produces a weight increase in toads.
A large increase in body weight occurred after injection of 6-hydroxydopamine (6-OHDA, 100 mg kg-1) into the iliac lymph sac of toads. The body weight increase was apparently due to retention of fluid and only occurred when toads could not avoid contact of their ventral skin with water. Lower doses of 6-OHDA (25 or 50 mg kg-1) did not cause a weight increase although they were sufficient to eliminate fluorescence from peripheral adrenergic nerves. A peripheral injection of 6-OHDA did not affect the appearance of central aminergic nerves. Removal of the pituitary and median eminence did not affect the weight increase. Although the primary action of 6-OHDA in upsetting water balance in toads has not been revealed by this study, it is clearly not related to the chemical sympathectomy of adrenergic nerves.
D000320:Adrenergic Fibers / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002024:Bufo marinus; D002395:Catecholamines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D016627:Oxidopamine; D010525:Peripheral Nerves / Q000502:physiology; D010902:Pituitary Gland / Q000502:physiology
D002395:Catecholamines; D006892:Hydroxydopamines; D016627:Oxidopamine