Interferon-inducing activity of dipyridamole in mice.
The kinetics of interferon (IFN) production was studied in mice after intraperitoneal (i.p.) and oral administrations of dipyridamole. The substance showed a high IFN-inducing activity when given orally at single doses ranging from 12.5 to 100 mg/kg (1/21.5-1/172 of the single LD50 value): peak titres of 2048-4096 IU/ml in the blood serum were reached at 48 hr; elevated IFN levels persisted until day 5 after administration of the inducer. Significantly lower IFN titres were found after i.p. injection.
D000284:Administration, Oral; D000818:Animals; D004176:Dipyridamole / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007274:Injections, Intraperitoneal; D007369:Interferon Inducers; D007370:Interferon Type I / Q000096:biosynthesis*; D007700:Kinetics; D007739:L Cells / Q000187:drug effects; D051379:Mice
D007369:Interferon Inducers; D007370:Interferon Type I; D004176:Dipyridamole