title: The link between exercise, respiratory heat exchange, and the mast cell in bronchial asthma.
abstract: There are two apparently conflicting theories on the pathogenesis of exercise-induced asthma. One view is that exercise-induced asthma is directly related to respiratory heat exchange and that mast cells are not involved. The other theory explains exercise-induced asthma on the basis of a temperature-independent release of mast-cell mediators. A theory is put forward here that airway cooling in asthmatic subjects during exercise leads directly to mast-cell degranulation and that this explains the association between exercise, respiratory heat exchange, and mediator release.
mesh_terms: D001249:Asthma / Q000209:etiology*; D001250:Asthma, Exercise-Induced / Q000209:etiology* / Q000503:physiopathology; D002631:Chemotactic Factors, Eosinophil / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism*; D008954:Models, Biological; D005082:Physical Exertion; D012119:Respiration
chemical_list: D002631:Chemotactic Factors, Eosinophil