The effect of intravenous cimetidine on the absorption of orally administered diazepam and lorazepam.
1 The effect of intravenous cimetidine 200 mg or 400 mg on the absorption of lorazepam 2.5 mg tablet and diazepam 10 mg tablet and capsule was studied. 2 Considerable individual variation in plasma concentrations was found with all preparations. 3 Cimetidine increased the absorption of diazepam and lorazepam. 4 Capsule preparations of diazepam generally produced higher drug plasma concentrations than the tablets.
D000284:Administration, Oral; D000328:Adult; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D002214:Capsules; D002927:Cimetidine / Q000494:pharmacology*; D003975:Diazepam / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects*; D008140:Lorazepam / Q000378:metabolism*; D013607:Tablets
D014151:Anti-Anxiety Agents; D002214:Capsules; D006146:Guanidines; D013607:Tablets; D002927:Cimetidine; D008140:Lorazepam; D003975:Diazepam