Anticonflict action of sodium valproate. Interaction with convulsant benzodiazepine (Ro 5-3663) and imidazodiazepine (Ro 15-1788).
The possibility that Ro 15-1788, a specific benzodiazepine antagonist would reverse the anxiolytic effect of VPA (200 mg/kg) in the Geller-Seifter paradigm was tested, using male albino rats. VPA (200 mg/kg) induced disinhibition which was antagonized by a convulsant benzodiazepine, Ro 5-3663 (1 mg/kg), but not by imidazobenzodiazepine, Ro 15-1788 at doses of 10 mg/kg, or 30 mg/kg. However, Ro 15-1788 (30 mg/kg) did have a short lasting antagonistic effect on VPA when tested in a "condensed" form (see text) of the conflict test. The nature of the anticonflict potency of VPA is discussed.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology*; D003220:Conflict, Psychological; D003292:Convulsants / Q000494:pharmacology; D004347:Drug Interactions; D005442:Flumazenil; D008297:Male; D014635:Valproic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D003292:Convulsants; D005442:Flumazenil; D014635:Valproic Acid; C022193:Ro 5-3663