title: Rapid thymomas induced by Abelson murine leukemia virus.
abstract: Abelson murine leukemia virus (A-MuLV) is derived from the thymotropic Moloney leukemia virus. However, injection of mice with A-MuLV by conventional routes results in rapidly arising peripheral and bone marrow lymphomas, not thymomas or T cell tumors. In this study thymomas have been induced by intrathymic injection of A-MuLV into BALB/c and C57BL/Ka mice. In both strains thymomas arose with short latent periods, comparable with the latencies of nonthymic tumors induced by intraperitoneal injection of A-MuLV and significantly shorter than those of thymomas induced by intrathymic injection of Moloney leukemia virus. Cells of the BALB/c thymomas were predominantly Thy-1-; those of C57BL/Ka thymomas were predominantly Thy-1+. Tissue culture lines were established and cloned. Some of these expressed low amounts of Thy-1 and one also expressed Lyt-1. Virus from cloned lines transformed 3T3 cells in vitro and induced Abelson disease in vivo when injected intraperitoneally into neonates. The A-MuLV p120 protein has been precipitated from metabolically labeled cell lysates of one cloned Thy-1+ line. These results show that A-MuLV can transform cells in the T lymphocyte lineage.
mesh_terms: D000011:Abelson murine leukemia virus / Q000472:pathogenicity*; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D002460:Cell Line; D002472:Cell Transformation, Viral; D005260:Female; D009052:Leukemia Virus, Murine / Q000472:pathogenicity*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology / Q000382:microbiology; D018800:Thy-1 Antigens; D013945:Thymoma / Q000276:immunology / Q000382:microbiology*; D013953:Thymus Neoplasms / Q000276:immunology / Q000382:microbiology*; D014779:Virus Replication
chemical_list: D000954:Antigens, Surface; D018800:Thy-1 Antigens