High somatostatin uptake by the isolated perfused dog pancreas consistent with "insulo-acinar" axis.
The canine pancreas takes up 50-80% of somatostatin perfused over a concentration range of 20 to 4000 pg/ml, compared to less than 21% of insulin or glucagon. This high uptake by acinar tissue of somatostatin, a potent inhibitor of acinar function, is compatible with a system for selective intrapancreatic control of exocrine pancreatic function via the insulo-acinar portal venous system.
D000818:Animals; D004285:Dogs; D005934:Glucagon / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010477:Perfusion; D013004:Somatostatin / Q000378:metabolism*
D007328:Insulin; D013004:Somatostatin; D005934:Glucagon