title: The influence of vascular beta-adrenoceptors on the position and mobility of the rabbit incisor tooth.
abstract: The influence of vascular beta-adrenoceptors on the tooth-supporting functions of the periodontal ligament were studied in 30 anesthetized rabbits. Propranolol and the beta 2-adrenoceptor antagonists ICI 118,551 and H 35/25 induced a marked extrusion of the incisor, probably due to reduced vasodilator tone in periodontal postcapillary blood vessels. Isoprenaline reversed the movement. beta 1- and beta 2-receptor antagonists decreased the intrusive responses to sympathetic nerve stimulation in teeth close to control position, but had no effect on responses in fully extruded teeth. Intrusive mobility, as tested by intermittent loading with 5-10 g, remained unaffected by beta-adrenoceptor blockade. The results suggest that vascular beta 2-adrenoceptors are important in the regulation of tooth position by their control of periodontal postcapillary resistance. Prejunctional beta-receptors enhancing the vasoconstrictor--and intrusive--responses to sympathetic nerve stimulation are probably a mixture of beta 1- and beta 2-receptors. It would seem that the periodontal vasculature is important for the position of the rabbit tooth but, due to rapid adaptive mechanisms of the tooth-supporting tissues, the vasculature contributes little to the resistance against load-induced intrusive movements of the tooth.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007180:Incisor / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D010513:Periodontal Ligament / Q000098:blood supply*; D011412:Propanolamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D013564:Sympathetic Nervous System / Q000502:physiology; D014086:Tooth Mobility; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C004380:H 35-25; C026777:ICI 118551; D011433:Propranolol; D008790:Metoprolol; D004809:Ephedrine; D007545:Isoproterenol