[Effect of beta-adrenoblockaders on the smooth muscles of the trachea and bronchi].
It has been shown in experiments on anesthetized guinea-pigs that (+/-) and (+) propranolol produced a dose-dependent increase in the resistance of the air ways. Meanwhile oxprenolol, trimepranol and atenolol had a poor bronchoconstrictor effect, and labetalol evoked no changes in the tone of the bronchi. On an isolated trachea of the guinea-pig both forms of propranolol, as well as trimepranol and oxprenolol produced contractions, atenolol did not cause any changes in the tone of the smooth muscles, while labetalol made the smooth muscles relax. It has been also demonstrated on an isolated trachea that pretreatment with atropine, diphenhydramine, and diethylamide of lysergic acid did not lead to any noticeable changes in the bronchoconstrictive action of propranolol. At the same time verapamil and Ca2+-free Krebs solution reversed the propranolol effect.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects
D000319:Adrenergic beta-Antagonists
Vliianie beta-adrenoblokatorov na gladkie myshtsy trakhei i bronkhov.