Induction of implantation in rats by a nonsteroidal antifertility agent, 1,2-diethyl-1,3-bis(p-methoxyphenyl)-1-propene.
A nonsteroidal antifertility agent 1,2-diethyl-1,3-bis(p-methoxyphenyl)-1-propene has been investigated to assess its capacity to induce implantation in delayed rats. The administration of the compound successfully induced the implantation in all rats. We have concluded that the process of induction of implantation in such rats may be due to a frank estrogenic action of the compound. Furthermore, the use of the compound as a new oral substitute for diethylstilbestrol is suggested.
D000818:Animals; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D010064:Embryo Implantation / Q000187:drug effects*; D010065:Embryo Implantation, Delayed / Q000187:drug effects*; D005260:Female; D008297:Male; D051381:Rats
D004054:Diethylstilbestrol; C027438:1,2-diethyl-1,3-bis(4-methoxyphenyl)-1-propene