Inotropic effect of prenalterol in amitriptyline poisoning.
A case of severe amitriptyline poisoning with grade IV coma, seizures, bradycardia and hypotension who did not respond to dopamine was successfully treated with prenalterol, a new cardioselective beta-agonist. The case is discussed with respect to plasma concentrations of dopamine, prenalterol and amitriptyline. Prenalterol, hydrocortisone and insulin may be useful as inotropic agents in tricyclic poisoning where dopamine fails to provide an adequate response.
D000318:Adrenergic beta-Agonists / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D000639:Amitriptyline / Q000097:blood / Q000506:poisoning*; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011217:Practolol / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D011294:Prenalterol
D000318:Adrenergic beta-Agonists; D000639:Amitriptyline; D011294:Prenalterol; D011217:Practolol