Antiviral action of dipyridamole and its derivatives against influenza virus A.
Dipyridamole proved to be active against influenza viruses A/England 42/72, A/Bangkok 1/79 and A/fowl plague (FPV). The antiviral activities assayed by various methods varied from 90-99 per cent. No inhibition was found against influenza virus B/Leningrad 235/74 in vitro. Three dipyridamole derivatives were significantly active in tissue cultures against influenza virus A/England 42/72 and A/FPV. In white mice infected with influenza virus A/England 42/72 dipyridamole administered orally showed a protection rate of 62.5 per cent.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004176:Dipyridamole / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D009980:Influenza A virus / Q000187:drug effects*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D012299:Rimantadine / Q000627:therapeutic use
D000998:Antiviral Agents; D012299:Rimantadine; D004176:Dipyridamole