Enhancement of rectal absorption of insulin using salicylates in dogs.
Sodium salicylate and 5-methoxysalicylate both increased the rectal absorption of insulin in dogs when co-administered with insulin in various formulations. Microenema formulations containing 4% gelatin showed the highest insulin bioavailability of the formulations studied whereas microenemas (without gelatin) and suppository formulations were not as effective in enhancing the rectal absorption of insulin.
D000818:Animals; D001682:Biological Availability; D004285:Dogs; D004733:Enema; D062425:Hydroxybenzoate Ethers; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D012007:Rectum / Q000378:metabolism*; D012459:Salicylates / Q000494:pharmacology*; D012980:Sodium Salicylate / Q000494:pharmacology*; D013488:Suppositories
D062425:Hydroxybenzoate Ethers; D007328:Insulin; D012459:Salicylates; D013488:Suppositories; C033304:5-methoxysalicylic acid; D012980:Sodium Salicylate