Receptors for pyelonephritogenic Escherichia coli in primates.
P-fimbriated Escherichia coli adhere to uroepithelial cells of monkeys by binding to receptors which are identical or very similar to those of man. In atraumatic experimental infections of monkeys, a P-fimbriated Escherichia coli strain induced ureteral malfunction with subsequent pyelonephritis. A non-P-fimbriated Escherichia coli strain did not. Thus, P-fimbriation of Escherichia coli represents a true virulence factor in the acquisition of pyelonephritis.
D000268:Adhesiveness; D000818:Animals; D004848:Epithelium / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D004926:Escherichia coli / Q000472:pathogenicity / Q000648:ultrastructure; D004927:Escherichia coli Infections / Q000378:metabolism / Q000382:microbiology*; D005260:Female; D010861:Fimbriae, Bacterial / Q000378:metabolism; D066298:In Vitro Techniques; D008252:Macaca fascicularis; D008253:Macaca mulatta; D010215:Papio; D011704:Pyelonephritis / Q000382:microbiology*; D014774:Virulence