[Role of lipid peroxidation in inhibiting cardiac Na, K-ATPase during stress].
Induction of lipid peroxidation (LPO) under emotional painful stress in rats in vivo and by the Fe2+ plus ascorbate system in vitro results in inactivation of Na,K-ATPase in the sarcolemma-rich membrane fraction of the heart. Activity of Mg-ATPase remains practically unchanged. The scavenger of lipid free radicals 4-methyl-2,6-ditertbutylphenol (ionol) prevents Na,K-ATPase inactivation in both cases. It is concluded that LPO plays the key role in the impairment of the heart Na-pump function under stress and that such impairment can be prevented by free radical scavengers. The stress-induced shifts in the ionic homeostasis in cardiomyocytes are discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D017301:Ca(2+) Mg(2+)-ATPase; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013315:Stress, Psychological / Q000201:enzymology*
D000975:Antioxidants; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase
Rol' perekisnogo okisleniia lipidov v ingibirovanii Na, K-ATFazy serdtsa pri stresse.