A comparison of some psychological and physiological effects exerted by zetidoline (DL308) and by oxazepam.
In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-308 (20 mg) exerted a strong sedative effect as judged by self-reported coordination scores and performance on logical reasoning and reaction time tests. The effect was evident almost immediately and, on the coordination and reasoning tests, lasted up to 8 h following ingestion. Attention is drawn to the need to extend performance testing in order to maximise test sensitivity. No drug had any consistent or strong influence on cardiovascular measures.
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004311:Double-Blind Method; D004644:Emotions / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D010076:Oxazepam / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D014785:Vision, Ocular / Q000187:drug effects
D014150:Antipsychotic Agents; D007093:Imidazoles; C027277:zetidoline; D010076:Oxazepam