Effects of H2O2 on the dogfish (Mustelus canis) ocular lens.
The influence of in vitro exposure of dogfish (Mustelus canis) lenses to H2O2 was studied. Concentrations of H2O2 greater than 10(-4)M caused opacities in the outer cortex of the lens within a few hr. Evidence of protein aggregation within the lens and in extracted lens protein solutions was found. Dithiothreitol inhibits aggregation. Little if any influence of H2O2 was observed on 86Rb exchange of the dogfish lens.
D000818:Animals; D003459:Crystallins / Q000032:analysis; D004284:Dogfish; D004591:Electrophoresis, Polyacrylamide Gel; D006861:Hydrogen Peroxide / Q000633:toxicity*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000187:drug effects*; D013997:Time Factors
D003459:Crystallins; D006861:Hydrogen Peroxide