Synthesis and pharmacologic assessment of carbamic and carbonic acid esters with 1-aryl-3-dimethylamino-1-propanols. Part 3.
The synthesis and results of the pharmacologic assessment of new carbamic and carbonic acid esters with a stimulatory effect on the CNS are described. The structural analogues of carbamic acids are less toxic as compared to imipramine and to the respective derivatives of carbonic acid, and are also more active pharmacologically than some of the screening tests for antidepressant action. According to the test of antagonizing reserpine-induced hypothermia, the compounds coded 3a, 4a, 4c, 4d exert a stronger effect by comparison with that of imipramine.
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D002254:Carbonates / Q000138:chemical synthesis* / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D007099:Imipramine / Q000633:toxicity; D051379:Mice; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D012110:Reserpine / Q000037:antagonists & inhibitors
D000928:Antidepressive Agents; D002219:Carbamates; D002254:Carbonates; D000697:Central Nervous System Stimulants; D011412:Propanolamines; D012110:Reserpine; D007099:Imipramine