Effects of diltiazem hydrochloride on serum lipids: comparison with beta-blockers.
The effects of diltiazem hydrochloride, a vasodilator often used to treat hypertension, and beta-blockers (pindolol and propranolol hydrochloride) on lipid metabolism and carbohydrate metabolism were assessed by measuring serum levels of total cholesterol, high-density-lipoproteins (HDL)-cholesterol, triglycerides, and glucose in patients taking these drugs for three months. No significant changes were observed in any of the values in patients taking either diltiazem hydrochloride (180 mg/day) or beta-blockers (15 mg of pindolol or 60 mg of propranolol daily). The decrease in HDL-cholesterol levels and increase in triglyceride levels reported in 1978 to be associated with use of propranolol, and with the concomitant use of hydrochlorothiazide and propranolol, was not found.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000375:Aging; D001552:Benzazepines / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003920:Diabetes Mellitus / Q000097:blood; D004110:Diltiazem / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D000319:Adrenergic beta-Antagonists; D001552:Benzazepines; D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides; D004110:Diltiazem