Effects of chemical modification on the L-glutamate receptors on the Onchidium neuron.
In the G-H cells of Onchidium oesophageal ganglia, L-glutamate (L-glu) elicited hyperpolarizations caused by an increase in potassium permeability. To identify the chemical groups of the structure of the L-glu receptor, which is involved in the L-glu response, the effects of chemical modifications were studied. Modifications of SH, guanidino, COOH, or NH2 groups depressed L-glu response. The modification of other polar amino acid residues and phospholipids, however, did not have an effect on the L-glu responses.
D000818:Animals; D003931:Diacetyl / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D005033:Ethylmaleimide / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D007531:Isoflurophate / Q000494:pharmacology; D008974:Mollusca / Q000502:physiology*; D008982:Molybdenum / Q000494:pharmacology; D009474:Neurons / Q000032:analysis*; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000187:drug effects; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000032:analysis*; D013329:Structure-Activity Relationship; D014302:Trinitrobenzenesulfonic Acid / Q000494:pharmacology
D005971:Glutamates; D011804:Quinolines; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D007531:Isoflurophate; D018698:Glutamic Acid; D011732:Pyridoxal Phosphate; C000470:EEDQ; D008982:Molybdenum; D014302:Trinitrobenzenesulfonic Acid; D003931:Diacetyl; D005033:Ethylmaleimide; C022175:ammonium molybdate; D004229:Dithiothreitol