title: Inhibition by enkephalins of peristaltic activity of the rabbit ileum and its reversal by naloxone.
abstract: Two pentapeptides, the enkephalins have been isolated and identified from the mammalian gastrointestinal tract and have been shown to be potent opiate agonists (Hughes 1975; Lord et al 1977; Hughes et al 1977). Further work has demonstrated that methionine (met-)-enkephalin and D-Ala2-Leu-enkephalinamide affected the peristaltic reflex of the guinea-pig isolated ileum (van Nueten et al 1977; Kromer et al 1980). On the other hand, the rabbit isolated ileum has been scarcely used as model to study the peristaltic reflex (Feldberg & Lin 1949; Beleslin et al 1978). However, after evidence of the existence of met- and leucine (leu)-enkephalin as well as of enkephalin receptors in the rabbit intestine was reported (Hughes et al 1977; Oka 1980) it became interesting to investigate the action of enkephalins on the peristaltic activity of rabbit isolated ileum.
mesh_terms: D000818:Animals; D004744:Enkephalin, Methionine / Q000494:pharmacology; D004745:Enkephalins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D010528:Peristalsis / Q000187:drug effects*; D011817:Rabbits
chemical_list: D004745:Enkephalins; D009270:Naloxone; D004744:Enkephalin, Methionine