[Effect of pretreatment with the alpha-adrenoblocker phentolamine and the beta-adrenoblocker inderal on the stress-induced decrease in adrenoreactivity of the portal vein].
The effect of the pretreatment with the alpha-adrenoblocker phentolamine and the beta-adrenoblocker inderal was studied on the disturbances of contractile function and adrenoreactivity which occurred after exposure to emotional-painful stress. The pretreatment of the animals exposed to emotional-painful stress with phentolamine prevented to a considerable degree the depression of portal vein contractility and raised adrenoreactivity of the smooth muscle that dramatically fell after emotional-painful stress to the basic level. Administration of inderal did not prevent the stress-induced disturbances. The data obtained suggest that the stress-induced injuring effect of catecholamine high concentrations is mediated via alpha-adrenoreceptors of portal vein smooth muscles.
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000818:Animals; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D010646:Phentolamine / Q000494:pharmacology*; D011169:Portal Vein / Q000503:physiopathology; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D010646:Phentolamine
Vliianie predvaritel'nogo vvedeniia al'fa-adrenoblokatora fentolamina i beta-adrenoblokatora inderala na stressornoe padenie adrenoreaktivnosti vorotnoĭ veny.