[11C-Ro15-1788 and 11C-flunitrazepam, two coordinates for the study by positron emission tomography of benzodiazepine binding sites].
In vivo binding of a benzodiazepine (flunitrazepam-C11) and a benzodiazepine antagonist (Ro 15-1788-C11) were studied with positron emission tomography. Advantages and disadvantages of each drug for studying specific in vivo binding sites are presented. The results obtained indicate that Ro 15-1788-C11 is a better in vivo radiocoordinat than flunitrazepam-C11.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001569:Benzodiazepines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D001570:Benzodiazepinones / Q000378:metabolism*; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D005442:Flumazenil; D005445:Flunitrazepam / Q000378:metabolism*; D007700:Kinetics; D010215:Papio; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011963:Receptors, GABA-A; D014055:Tomography, Emission-Computed / Q000379:methods
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005442:Flumazenil; D005445:Flunitrazepam
11C-Ro 15-1788 et 11C-flunitrazepam, deux coordinats pour l'étude par tomographie par positons des sites de liaison des benzodiazépines.