Contractile actions of lysophosphatidic acids with a chemically-defined fatty acyl group on longitudinal muscle from guinea-pig ileum.
Various lysophosphatidic acids caused phasic contractions of longitudinal muscle from guinea-pig ileum, followed by rhythmical contractions of lower magnitude. Polyunsaturated lysophosphatidic acids were more potent than saturated lysophosphatidic acids. Among the lysophosphatidic acids tested, linolenoyl-lysophosphatidic acid was the most active, but its activity was about 3-5 times less than that of prostaglandin F2 alpha. Contractile responses to various lysophosphatidic acids, were partially suppressed by tetrodotoxin, atropine and chlorpheniramine. In addition, lysophosphatidic acid-induced contractions were considerably reduced by pretreatment of the muscle with indomethacin.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D005227:Fatty Acids / Q000032:analysis; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008246:Lysophospholipids; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010712:Phosphatidic Acids / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology
D005227:Fatty Acids; D008246:Lysophospholipids; D010712:Phosphatidic Acids; D011453:Prostaglandins; D007213:Indomethacin