[Neuroleptics in geriatrics. Pharmacological criteria for a responsible choice and a correct use].
Elderly patients are very vulnerable to the effects of neuroleptic drugs. By a right choice and an adequate individual dosage adjustment many side-effects can be avoided. Pharmacological data can provide a useful tool to achieve this. They can predict the possibility of cardiovascular, parasympathicolytic and hypnosedative side-effects. Extrapyramidal side-effects induced by neuroleptic treatment can almost always be overcome by dosage-adjustment. Potent neuroleptics, with a specific mode of action, are to be preferred as antipsychotic agents especially in the elderly.
D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000378:metabolism*; D006801:Humans; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism
D014150:Antipsychotic Agents; D011942:Receptors, Adrenergic, alpha; D011956:Receptors, Cell Surface; D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D011968:Receptors, Histamine; D011985:Receptors, Serotonin
Neuroleptica in de geriatrie. Farmacologische criteria voor een verantwoorde keuze en een juist gebruik.