title: The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord.
abstract: The effects of the dissociative anaesthetic, etoxadrol, and the stereoisomers of dioxadrol, dexoxadrol and levoxadrol, were examined on the excitation of spinal neurones by electrophoretically administered amino acids in pentobarbitone- or urethane-anaesthetized rats, or pentobarbitone-anaesthetized cats. Both etoxadrol and the (+)isomer of dioxadrol, dexoxadrol, administered locally or systemically, exhibited a selective antagonism of N-methyl-D,L-aspartate relative to quisqualate and kainate. This selective antagonism was not observed with the (-)isomer of dioxadrol, levoxadrol. Since such a stereoselective antagonism of the excitation of spinal neurones by N-methyl-D,L-aspartate is also displayed by the dissociative anaesthetics phencyclidine and ketamine, it is suggested that a reduced efficiency at excitatory synapses utilising N-methyl-D,L-aspartate receptors contributes to that part of the pharmacological spectrum common to both arylcyclohexylamines and dioxolanes.
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D002415:Cats; D004148:Dioxolanes / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D007608:Kainic Acid / Q000037:antagonists & inhibitors; D007649:Ketamine / Q000494:pharmacology; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000037:antagonists & inhibitors; D010622:Phencyclidine / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D013045:Species Specificity; D013116:Spinal Cord / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004148:Dioxolanes; D004149:Dioxoles; D010069:Oxadiazoles; D001224:Aspartic Acid; D016202:N-Methylaspartate; D007649:Ketamine; D016318:Quisqualic Acid; D010622:Phencyclidine; D007608:Kainic Acid