title: Effect of somatostatin and its fragments on turning behaviour induced by unilateral substantia nigra lesion in the rat.
abstract: The effect of somatostatin and its two tetrapeptide fragments was investigated on turning activity induced by unilateral substantia nigra lesion in rats. Somatostatin in a dose of 0.6 nM had no action on the turning behavior, while a dose of 6 nM increased slightly while a dose of 12 nM significantly the contralateral turning. Cys-Lys-Asn-Phe and Phe-Trp-Lys-Thr had no action in low or high doses on the turning activity of the animals. The results suggest that somatostatin has a direct postsynaptic dopamine receptor stimulating effect. It seems that for dopamine receptor stimulating action the complete somatostatin molecule is needed.
mesh_terms: D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D016627:Oxidopamine; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*; D013378:Substantia Nigra / Q000378:metabolism / Q000502:physiology*
chemical_list: D000662:Amphetamines; D006892:Hydroxydopamines; D010446:Peptide Fragments; D013004:Somatostatin; D016627:Oxidopamine; C043313:somatostatin(3-6); C043312:somatostatin(7-10); D001058:Apomorphine; D004298:Dopamine