Influence of a continuous intragastric and intravenous infusion of somatostatin on stimulated gastric secretion.
Our study demonstrated that somatostatin given i.v. in a dose of 250 micrograms/kg per hour significantly inhibited pentagastrin-stimulated gastric secretion, whereas continuous intragastric administration of somatostatin (up to 3 mg/h) failed to do so. We concluded, therefore, that luminally secreted somatostatin plays only a minor role in the regulation of gastric secretion.
D000284:Administration, Oral; D000328:Adult; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*
D013004:Somatostatin; D010418:Pentagastrin