Diurnal variations in circulating hormone levels and brown adipose tissue activity in "cafeteria"-fed rats.
Circulating hormone levels and interscapular brown adipose tissue (BAT) mitochondrial GDP-binding capacity were measured at 4-hr intervals over 24 hr in rats fed a stock diet or a palatable "cafeteria" diet. Plasma thyroxine, insulin and glucagon levels were unaffected by diet, but plasma triiodothyronine, BAT mass, mitochondrial protein content and GDP-binding were higher in cafeteria-fed rats. Blood glucose levels and BAT mitochondrial GDP-binding were higher at night in the cafeteria rats. The diurnal variations in these parameters correlated with changes in diet-induced thermogenesis previously observed in cafeteria-fed rats.
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002940:Circadian Rhythm; D004032:Diet; D005934:Glucagon / Q000097:blood; D006728:Hormones / Q000097:blood*; D007328:Insulin / Q000097:blood; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D006728:Hormones; D007328:Insulin; D005934:Glucagon