On metabolic effects of diuretics and beta-blockers. Results from a cross-sectional and longitudinal population study of women.
A population sample of women in Göteborg, Sweden, was studied in 1968-69 and restudied in 1974-75. A number of metabolic variables could be studied cross-sectionally (in 1974-75) and longitudinally (intraindividual changes between 1968-69 and 1974-75). When studied cross-sectionally, increased serum urate concentrations were observed in women on diuretics and increased serum triglycerides in women on beta-blockers, compared to other women, while no obvious differences were found in blood glucose and serum cholesterol concentrations or in packed red cell volume (PCV). When studied longitudinally, a slight decrease in serum triglyceride concentration was found in women who started to take diuretics and an increase in women who started to beta-blockers compared to other women. Serum urate concentration tended to increase in women who started to take diuretics and PCV tended to decrease in women who started to take beta-blockers. Blood glucose was unimpaired. In conclusion, the differences observed were rather small and seemed to be rather unimportant compared to the threat presented by the arterial hypertension itself.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D004232:Diuretics / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D013548:Sweden; D013972:Thyrotropin / Q000097:blood; D014280:Triglycerides / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood; D014527:Uric Acid / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D004232:Diuretics; D014280:Triglycerides; D014284:Triiodothyronine; D014527:Uric Acid; D013972:Thyrotropin; D002784:Cholesterol