Intragastric self-administration in rhesus monkeys under limited access conditions: methodological studies.
Rhesus monkeys were trained to self-administer psychoactive drugs by the intragastric route of administration under limited access conditions and intermittent schedules of drug delivery. Under a fixed-ratio 10 schedule, pentobarbital, diazepam, and cocaine maintained self-administration in some monkeys. Responding was not maintained by d-amphetamine under these conditions. Under fixed-ratio 10 (timeout 2 min) conditions, cocaine maintained self-administration in all animals (5/5) tested, while pentobarbital maintained responding in 2/3. At doses higher than that which maintained maximal rates, responding was inversely related to dose/injection. Drug intake was relatively constant across dose/injection of cocaine, but was a direct function of dose/injection of pentobarbital and diazepam. The procedure may be useful in assessing behavioral and pharmacological variables controlling oral self-administration of drugs.
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal; D008253:Macaca mulatta; D008297:Male; D011619:Psychotropic Drugs / Q000008:administration & dosage*; D012055:Reinforcement Schedule; D012646:Self Administration
D000697:Central Nervous System Stimulants; D011619:Psychotropic Drugs; D003042:Cocaine