Central nervous system regulation of adrenocorticotropin secretion: role of somatostatins.
Somatostatin-28 (SS-28) and desAA1,2,4,5,12,13[D-Trp8]somatostatin (ODT8-SS), but not somatostatin-14, given intracerebroventricularly, but not when given iv, inhibit stress-induced pituitary ACTH and adrenomedullary epinephrine secretion in rats. The elevation of ACTH after tail-suspension stress is totally prevented by iv administration of antisera raised against corticotropin-releasing factor (CRF). SS-28 and ODT8-SS do not inhibit CRF-induced ACTH secretion in vivo or in vitro. These results are consistent with the hypothesis that SS-28 and ODT8-SS prevent stress-induced ACTH secretion by inhibition of CRF release.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004837:Epinephrine / Q000097:blood; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology* / Q000031:analogs & derivatives; D053561:Somatostatin-28; D013312:Stress, Physiological / Q000378:metabolism*
D010446:Peptide Fragments; D013004:Somatostatin; C017583:somatostatin, octapeptide-Trp(8)-; D053561:Somatostatin-28; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine; D004837:Epinephrine