Wilms' tumour: association with cellular sensitivity to mitomycin C in patients and first-degree relatives.
To investigate whether predisposition to Wilms' tumour is associated with a particular defect in the handling of DNA damage, cell-lines from families in which the tumour had occurred were tested for sensitivity to a variety of DNA-damaging agents. Lymphoblastoid lines from both Wilms' tumour patients and their first-degree relatives showed increased sensitivity to the cross-linking agent, mitomycin C, but normal sensitivity to ultraviolet (UV) and gamma irradiation. Thus sensitivity to mitomycin C damage can be associated with the Wilms'-tumour-susceptible genotype and could be a genetic factor responsible for the modification of expression of this genotype.
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002648:Child; D002869:Chromosome Aberrations; D004198:Disease Susceptibility; D005260:Female; D005720:Gamma Rays; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000648:ultrastructure; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays; D009396:Wilms Tumor / Q000235:genetics* / Q000648:ultrastructure
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D016685:Mitomycin