Effect of neoplasms on the content and activity of alkaline phosphatase and gamma-glutamyl transpeptidase in uninvolved host tissues.
In rats carrying s.c. or i.p. neoplasms, there were striking (3- to 20-fold) rises in the gamma-glutamyl transpeptidase and alkaline phosphatase activity of several tissues. These included liver, lung, spleen, bone marrow, and circulating granulocytes but not lymphocytes. In response to mammary carcinoma 5A, for example, the gamma-glutamyl transpeptidase activity changed from 0.27 to 1.18 units/g lung and from 0.3 to 4.0 milliunits/million granulocytes; from 2.3 to 17 units and from 2.4 to 46 milliunits were the accompanying increases in alkaline phosphatase. These abnormalities in each host tissue were reversible in that 3 to 7 days after tumor resection the enzymes returned to control levels. Among the secondary factors which might have been responsible for the host tissue changes, it was possible to exclude stimulated adrenocortical secretion, tissue necrosis, and transplantation trauma. Comparisons of the effects of two mammary carcinomas, a fibrosarcoma, and two hepatomas on the gamma-glutamyl transpeptidase and alkaline phosphatase of various "noninvolved" tissues indicate that the faster the growth rate of the tumors, the more striking is this host syndrome.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001853:Bone Marrow / Q000201:enzymology; D006854:Hydrocortisone / Q000494:pharmacology; D007422:Intestines / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D007962:Leukocytes / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008168:Lung / Q000201:enzymology; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D006854:Hydrocortisone