Modulation of N-nitrosodimethylamine kidney tumorigenesis by unilateral hydronephrosis and multiple putrescine administrations.
The effects of unilateral hydronephrosis by ligation of the right ureter and/or multiple injections of putrescine on kidney tumorigenesis by a single intrarenal injection of N-nitrosodimethylamine (DMN) were studied. Inbred female W rats in the unilateral hydronephrotic groups given or not given putrescine developed kidney tumors and/or neoplastic or preneoplastic lesions of the liver at an incidence of 55.6%. Almost all kidney tumors developed in the contralateral kidneys, which showed hypertrophy due to unilateral hydronephrosis. Rats having unilateral hydronephrosis and subjected to long-term putrescine administration after DMN injection frequently contracted large mesenchymal cell tumors (83%), whereas the group not given putrescine developed no mesenchymal cell tumors. Histologically, epithelial cell tumors showed a marked decrease in both gamma-glutamyltransferase activity and trypan blue uptake, but mesenchymal cell tumors did not.
D000818:Animals; D001835:Body Weight; D004128:Dimethylnitrosamine / Q000633:toxicity*; D005260:Female; D006869:Hydronephrosis; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced; D009392:Nephrectomy; D009929:Organ Size; D011700:Putrescine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D014343:Trypan Blue / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D005723:gamma-Glutamyltransferase; D014343:Trypan Blue; D004128:Dimethylnitrosamine; D011700:Putrescine