The interaction of sea anemone and scorpion neurotoxins with tetrodotoxin-resistant Na+ channels in rat myoblasts. A comparison with Na+ channels in other excitable and non-excitable cells.
The properties of interactions of several polypeptide neurotoxins isolated from sea anemone and scorpion venom with Na+ channels of rat myoblasts, chick myotubes, neuroblastoma cells, and fibroblasts have been compared. Tetrodotoxin (TTX)-resistant Na+ channels appear to be much more sensitive to the action of sea anemone toxins than TTX-sensitive Na+ channels but have the same affinity for scorpion neurotoxins. This conclusion holds both for Na+ channels that can be activated electrically and for silent forms of Na+ channels. The sensitivity to sea anemone toxins of the different types of Na+ channels that have been studied suggests the existence of multiple forms of Na+ channels.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D003064:Cnidarian Venoms / Q000633:toxicity*; D004347:Drug Interactions; D004351:Drug Resistance; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D007700:Kinetics; D009132:Muscles / Q000502:physiology*; D009498:Neurotoxins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012604:Scorpion Venoms / Q000633:toxicity*; D012615:Sea Anemones; D012964:Sodium / Q000378:metabolism; D013779:Tetrodotoxin / Q000633:toxicity*
D003064:Cnidarian Venoms; D007473:Ion Channels; D009498:Neurotoxins; D012604:Scorpion Venoms; D013779:Tetrodotoxin; D012964:Sodium