[Effect of beta-adrenoagonists on peroxidation of lipids in the myocardium of the rat].
The intravenous 80 mg/kg injection of isadrine and novodrine decreases the amount of malonic dialdehyde in the rat myocardium tissue, which is explained by the active participation of lipid peroxides of the mitochondrial matrix in the respiratory processes. Beta-adrenoagonists are supposed to promote intensive expenditure of energy and to slow down its production. They may be both antioxidants and prooxidants depending on the dose, way of administration and initial state of the material under study.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000032:analysis / Q000378:metabolism*; D051381:Rats
D000318:Adrenergic beta-Agonists; D008054:Lipid Peroxides; D008315:Malondialdehyde; D003402:Creatine Kinase; D007545:Isoproterenol
Vliianie beta-adrenoagonistov na perekisnoe okislenie lipidov v miokarde krys.