Influence of smoking on serum protein composition and the protein binding of drugs.
The influence of smoking an alpha 1-acid glycoprotein (alpha 1-AGP) and serum albumin concentrations and the protein binding of phenytoin and propranolol in healthy volunteers was investigated. alpha 1-AGP concentrations were found to be statistically different (P less than 0.05) in the smokers (mean = 84.3 mg dl-1) versus non-smokers (mean = 62.8 mg dl-1). There was a trend for lower serum albumin concentrations and lower fraction unbound of propranolol in the smokers. Smoking did not affect the protein binding of phenytoin.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000097:blood*; D010672:Phenytoin / Q000097:blood; D011433:Propranolol / Q000097:blood; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism; D012907:Smoking
D001798:Blood Proteins; D009961:Orosomucoid; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; D010672:Phenytoin; D011433:Propranolol