Late-onset akathisia--an indicant of covert dyskinesia: two case reports.
Two patients receiving long-term depot antipsychotic treatment developed late-onset akathisia characterized by emergence toward the end of each injection interval. Drug dose reduction provoked exacerbation of the akathisia and the appearance of choreiform limb dyskinesia. The authors discuss a possible pathophysiological mechanism.
D000328:Adult; D017109:Akathisia, Drug-Induced; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000503:physiopathology; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D011595:Psychomotor Agitation / Q000503:physiopathology; D011954:Receptors, Dopamine / Q000502:physiology
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine