Organ-specific difference in the sugar chains of gamma-glutamyltranspeptidase.
Sugar chains of gamma-glutamyltranspeptidase purified from neonatal mouse liver and adult mouse kidney were quantitatively released as oligosaccharides from the polypeptide backbone by hydrazinolysis. A comparative study of the structures of the oligosaccharides has revealed that the GlcNAc beta 1 leads to 4Man beta 1 leads to group is found in the sugar chains of kidney enzyme but not in those of liver enzyme. This is considered as an organ-specific difference common to mammals because the same phenomenon was found in bovine and rat enzymes.
D000217:Acyltransferases / Q000302:isolation & purification; D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D009844:Oligosaccharides / Q000302:isolation & purification*; D009928:Organ Specificity; D013329:Structure-Activity Relationship; D011503:Transglutaminases
D009844:Oligosaccharides; D000217:Acyltransferases; D011503:Transglutaminases