Beta 2-adrenoceptor-induced hypotension in the ganglion-blocked angiotensin II-supported rat.
An in vivo method is described to demonstrate vascular beta 2-adrenoceptor agonist and antagonist activity. Agonist activity was shown by the ability of i.v. injected compounds to reduce blood pressure in ganglion-blocked, phenoxybenzamine-treated, angiotensin II-supported rats. Procaterol was employed to assess the relative beta 2 blocking activity of propranolol IPS 339 and atenolol. Arunlakshana and Schild analysis of the data revealed that all these compounds were competitively beta 2 antagonists, their relative potencies being 100 : 80 : 0.56 respectively.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005727:Ganglia, Spinal / Q000293:injuries; D007022:Hypotension / Q000209:etiology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D000804:Angiotensin II