title: Synthesis and antianxiety activity of (omega-piperazinylalkoxy)indan derivatives.
abstract: A series of (omega-piperazinylalkoxy)indan derivatives has been synthesized and screened for potential antianxiety activities. The effect of structural modification of these molecules on activities has been systemically examined. Antianxiety activity was displayed by 5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (2), 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]-propoxy]indan (8), 6-fluoro-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (33), and 6-methyl-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (42), as determined in antifighting and anti-morphine tests. These derivatives in antianxiety tests were equipotent or more potent than chlordiazepoxide with less muscle-relaxant effect. They also showed weak neuroleptic-like action.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis*; D001833:Body Temperature Regulation / Q000187:drug effects; D002375:Catalepsy / Q000503:physiopathology; D006801:Humans; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007192:Indenes / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors; D009043:Motor Activity / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D014151:Anti-Anxiety Agents; D007189:Indans; D007192:Indenes; D007202:Indicators and Reagents; D010879:Piperazines; D009020:Morphine