title: [Age dependence of increase in heart rate after vagolysis (author's transl)].
abstract: Age dependent decrease of heart rate in sinus rhythm at rest was shown under clinical and experimental conditions and correlated with a decrease of sympathetic storage granula and membranes indicated by the tissue concentrations of c-AMP, which can be regarded as a messenger at the receptor sites. A slower maximal heart rate after Atropine and a reduced increase during oral medication with Ipratropium bromide can be explained by a reduced cardiac sympathetic threshold. The mentioned age dependent differences of the sympathetic stimulation can not be deduced to myocardial changes, because CPK and CK-MB activities were similar in the different age groups.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001919:Bradycardia / Q000188:drug therapy; D004285:Dogs; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use; D009921:Metaproterenol / Q000494:pharmacology; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology; D013564:Sympathetic Nervous System / Q000187:drug effects; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
chemical_list: D009921:Metaproterenol; D001285:Atropine; D004299:Dopamine beta-Hydroxylase; D009241:Ipratropium
vernacular_title: Altersabhängigkeit der Frequenzsteigerung nach Vagolyse.