title: [Early trials of substances claimed to be anxiolytic].
abstract: Phase I and phase II studies of anxiolytic compounds have been described in details in some guidelines issued by various authorities. Their methodology leads to original problems with regard to objectives, subjects, and experimental design. The performance of such studies remains difficult especially due to the use of volunteers in phase I and to the use of placebo and diagnostic criteria in phase II.
mesh_terms: D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards*; D004341:Drug Evaluation / Q000379:methods / Q000592:standards; D006801:Humans
chemical_list: D014151:Anti-Anxiety Agents
vernacular_title: Les essais précoces de substances réputées anxiolytiques.