Development of resistance to 2-(1-amino-ethyl)-bicyclo (2.2.1) heptane chlorohydrate in influenza A virus.
A resistant influenza virus has been obtained during successive passages of influenza A virus in 10 to 11-day-old chick embryos (CE) in the presence of 2-(1'-amino-ethyl)-bicyclo(2.2.1) heptane chlorohydrate possessing a high antiviral activity. The virus resistance to the inhibitor was not lost after one passage in the absence of the drug.
D000998:Antiviral Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D009980:Influenza A virus / Q000187:drug effects*; D009636:Norbornanes / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D009636:Norbornanes; C034486:2-(1'-aminoethyl)bicyclo(2.2.1)heptane