Plasma histamine levels in patients in the course of several standard operations: influence of anaesthesia, surgical trauma and blood transfusion.
A prospective controlled clinical trial was conducted on changes in plasma histamine and catecholamine levels during 5 standard operations. This communication, as the first part of the trial, deals only with the feasibility of such a trial and the changes in plasma histamine levels. Elevated histamine concentrations corresponding to histamine-release responses of greater than 1 ng/ml occurred in 8 of 25 operations. In an explorative analysis these responses were associated with distinct phases of anaesthesia or the surgical procedure. Blood transfusion carried the risk of infusion of "free histamine" into the patient--especially when administered under pressure. Since during operations "free histamine" enters the circulation with a rather high incidence and may cause harmful effects, premedication with H1-+H2-receptor antagonists seems worth consideration.
D000328:Adult; D000368:Aged; D000758:Anesthesia / Q000009:adverse effects; D002986:Clinical Trials as Topic; D005260:Female; D006632:Histamine / Q000097:blood*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011292:Premedication; D011446:Prospective Studies; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D065227:Transfusion Reaction
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D006632:Histamine