Cholesterol synthesis and related enzymes in rat liver during pregnancy.
During pregnancy the synthesis of cholesterol and the activity of 3-hydroxy 3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase fell markedly before parturition; HMGCoA synthase activity was low during pregnancy and fell again immediately before delivery while acetoacetyl-CoA-thiolase was always low and constant.
D000101:Acetyl-CoA C-Acetyltransferase / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D005260:Female; D005865:Gestational Age; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats
D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D000101:Acetyl-CoA C-Acetyltransferase; D006904:Hydroxymethylglutaryl-CoA Synthase