The role of the sympathetic nervous system in atropine-induced tachycardia in conscious cats.
Injection of atropine sulphate induces tachycardia in conscious unrestrained cats. Injection of the same dose of atropine sulphate after a beta-blocking agent is accompanied by less severe tachycardia. We suggest that atropine sulphate-induced tachycardia in conscious cats, and in anaesthetized animals, is linked to changes in sympathetic-vagal balance, to activation of sympathetic centres and obviously to muscarinic antagonistic effects of atropine in sympathetic nerves.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D001286:Atropine Derivatives; D011433:Propranolol