A close correlation between the amount of met-enkephalin-immunoreactivity and epinephrine in adrenal pheochromocytoma tissue from patients with Sipple's syndrome.
The concentration of epinephrine, norepinephrine, dopamine, met-enkephalin-, ACTH-, calcitonin- and somatostatin-like immunoreactivity (IR) were determined in the extracts of 9 adrenal pheochromocytomas from 7 patients. Six of these patients had Sipple's syndrome. There was a close correlation between the amounts of met-enkephalin-IR and of epinephrine present in the tumor tissue (p less than 0.01). Such a correlation was not found between catecholamines and the other polypeptide hormones investigated. The relevance of the close parallel in the occurrence of met-enkephalin-IR and epinephrine in human adrenal pheochromocytoma tissue is unknown, but it underlines earlier observations in the normal bovine and rat adrenal medulla on a co-storage and co-release of these substances in normal circumstances.
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000032:analysis* / Q000235:genetics; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000328:Adult; D002116:Calcitonin / Q000032:analysis; D004744:Enkephalin, Methionine / Q000032:analysis*; D004837:Epinephrine / Q000032:analysis*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000032:analysis* / Q000235:genetics; D011863:Radioimmunoassay; D013004:Somatostatin / Q000032:analysis; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000235:genetics
D013004:Somatostatin; D004744:Enkephalin, Methionine; D000324:Adrenocorticotropic Hormone; D002116:Calcitonin; D004837:Epinephrine