[Action of compounds which predominantly affect the peripheral M-cholinoreactive systems on the bone marrow eosinophils].
Experiments on rats have shown that the blockade of M-cholinoreceptors with atropine (50,100 and 150 mg/kg) delays, while the stimulation of the M-cholinoreceptors with aceclidine (5, 10 and 15 mg/kg) intensifies the release of mature eosinophils from the bone marrow to the circulating blood. It is concluded that the peripheral M-cholinoreactive systems participate in the control of the release of the mature bone marrow eosinophils into the blood.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001854:Bone Marrow Cells; D004802:Eosinophilia / Q000503:physiopathology*; D004804:Eosinophils / Q000187:drug effects*; D005260:Female; D007958:Leukocyte Count; D011812:Quinuclidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000502:physiology
D011812:Quinuclidines; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D001285:Atropine
Vliianie preparatov, deĭstvuiushchikh preimushchestvenno v oblasti M-kholinoreaktivnykh sistem, na éozinofily kostnogo mozga.