Response of brain and pituitary pools of dynorphin as compared to vasopressin to acute stress in the rat.
5 min foot-shock resulted in an elevation in levels of immunoreactive (ir)-dynorphin (DYN) and ir-vasopressin (VP) in the hypothalamus whereas their levels were not significantly modified in the neurointermediate pituitary. In the anterior pituitary, however, a fall in ir-DYN in the absence of any change in ir-VP was detected. Further, in the thalamus and medulla/pons, respectively, a decrease and increase in levels of ir-VP was observed whilst the content of ir-DYN therein was not significantly affected. These findings support the concept of a common origin and co-modulation of DYN and VP in the hypothalamic-neural lobe axis and that, extrinsic to this, DYN and VP are localized and modulated independently of each other.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004399:Dynorphins; D004597:Electroshock; D004723:Endorphins / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology*; D014667:Vasopressins / Q000378:metabolism*
D004723:Endorphins; D014667:Vasopressins; D004399:Dynorphins