[Pharmacological correction of neurogenic disorders of cerebral circulation].
The paper discusses the data on the effect of adrenergic innervation on the cerebral circulation and possible approaches to the pharmacological action on cerebral blood vessels constriction. Attention is also paid to the effect of alpha-adrenoblockers (dihydroergotoxin, phenoxybenzamine, phentolamine, etc) on adrenoreactive structures and of that of sympatholytics (reserpine, octadin, ornid) on the presynaptic membrane of the adrenoreceptor. Relaxation or elimination of cerebral vessels spasms was observed under the influence of the drugs capable of affecting the central component of cerebral circulation control. Drugs with central adrenergic (nialamide, nitroglycerin) and GABA-ergic (GABA, sodium hydroxybutyrate, depaquin, diazepam, phenazepam, etc) activity exerted the same effect.
D000320:Adrenergic Fibers / Q000033:anatomy & histology / Q000187:drug effects; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects / Q000294:innervation; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000209:etiology; D004837:Epinephrine / Q000494:pharmacology; D018756:GABA Antagonists; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000150:complications* / Q000188:drug therapy; D013565:Sympatholytics / Q000627:therapeutic use; D014655:Vascular Resistance / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D018756:GABA Antagonists; D008996:Monoamine Oxidase Inhibitors; D013565:Sympatholytics; D005680:gamma-Aminobutyric Acid; D004837:Epinephrine
Farmakologicheskaia korrektsiia neĭrogennykh rasstroĭstv mozgovogo krovoobrashcheniia.