title: Antiviral activity in plants of a mycoviral double-strained RNA from Trichothecium roseum.
abstract: Hexagonal virus-like particles (VLPs) measuring 45 nm across were detected in mycelial extracts from Trichothecium roseum Himachal strain, the source fungus for the production of T-poly (Trichothecium polysaccharide), a known inhibitor of plant viruses. VLPs were found to contain double-stranded RNA (ds RNA) and the purified ds RNA was capable of inhibiting tobacco mosaic virus infection in Nicotiana glutinosa plants. Active preparations of T-poly were found to contain traces of ds RNA, probably of mycoviral origin.
mesh_terms: D003904:Mitosporic Fungi / Q000648:ultrastructure*; D011134:Polysaccharides / Q000302:isolation & purification; D012330:RNA, Double-Stranded / Q000302:isolation & purification*; D012331:RNA, Fungal / Q000302:isolation & purification*; D012367:RNA, Viral / Q000302:isolation & purification*; D014027:Tobacco Mosaic Virus / Q000187:drug effects; D014762:Viral Interference; D014771:Virion / Q000648:ultrastructure; D014779:Virus Replication / Q000187:drug effects
chemical_list: D011134:Polysaccharides; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D012367:RNA, Viral; C033609:tricothecium polysaccharide