title: Hepatic metallothionein production and resistance to heavy metals by rainbow trout (Salmo gairdneri)--II. Held in a series of contaminated lakes.
abstract: Rainbow trout held in net pens for 4 weeks in three locations contaminated by heavy metals developed elevated levels of hepatic metallothionein but no acclimation to a combination of zinc, copper and cadmium. Toxicity of the mixture of zinc, copper and cadmium in a ratio of 400:20:1 increased with temperature in the range of 6-21 degrees C. Hepatic metallothionein concentrations after 4 weeks of exposure in situ was correlated with the degree of contamination as measured by zinc concentrations (P less than 0.01).
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002119:Calcium Carbonate / Q000032:analysis; D004361:Drug Tolerance; D005618:Fresh Water; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008668:Metallothionein / Q000096:biosynthesis*; D008670:Metals / Q000032:analysis / Q000494:pharmacology*; D012487:Salmonidae / Q000502:physiology*; D012621:Seasons; D013696:Temperature; D014337:Trout / Q000502:physiology*; D014867:Water / Q000032:analysis; D014877:Water Pollution, Chemical / Q000032:analysis
chemical_list: D008670:Metals; D014867:Water; D008668:Metallothionein; D002119:Calcium Carbonate