title: [Guanidinothiazoles with H2-antihistaminic activity. 12: H2-antihistamines].
abstract: In studies on H2-antihistaminics, guanidinothiazoles were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium. Whereas the N,N'-disubstituted cyanoguanidines 3 and 5 possess stronger H2-activity than tiotidine, the 5-substituted 4-pyrimidinones 7a, b proved to be as effective as the reference substance.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D006146:Guanidines; D006635:Histamine H2 Antagonists; D013844:Thiazoles
vernacular_title: Guanidinothiazole mit H2-antihistaminischer Wirkung. 12. Mitt: H2-antihistaminika.