title: Ketotifen: a new drug for prophylaxis of asthma in children.
abstract: Ketotifen, an orally active, prophylactic anti-asthmatic drug, was compared with placebo in a double-blind, three-month parallel-group trial in 20 children. Children receiving ketotifen were more likely to reduce concomitant medications and had significant improvement over time in asthma scores and mean flows at 75%, 50%, and 25% of vital capacity. They also had a significantly increased incidence of dry mouth and significant weight gain compared to those receiving placebo. In some children with asthma, ketotifen may be a useful alternative to existing drugs.
mesh_terms: D000208:Acute Disease; D001249:Asthma / Q000175:diagnosis / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D002648:Child; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007665:Ketotifen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D011674:Pulse / Q000187:drug effects; D012129:Respiratory Function Tests; D014987:Xerostomia / Q000139:chemically induced
chemical_list: D006634:Histamine H1 Antagonists; D007665:Ketotifen