Effect of storage of penicillin-G solutions on sensitisation to penicillin-G after intravenous administration.
Intravenous administration of a total dose of more than 200 million IU of penicillin-G led to sensitisation of lymphocytes and formation of specific anti-penicilloyl antibodies of the IgG class. These effects were prevented when the penicillin solution used was freshly prepared and given as a bolus rather than as a slow infusion. The causative antigens seem to be related not to penicilloylated high molecular weight impurities in the penicillin preparations, but to the degradation and/or transformation products of penicillin-G that form when the drug is in solution even if only for a few hours, and not only at room temperature but also at 4 degrees C. Thus penicillin solutions should be freshly prepared and administered from vials containing less than 10 million IU so that bolus doses can be given.
D000328:Adult; D004342:Drug Hypersensitivity / Q000209:etiology*; D004356:Drug Storage; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007275:Injections, Intravenous; D007700:Kinetics; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D011852:Radioallergosorbent Test
D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010400:Penicillin G