Effect of oestrogen replacement therapy on blood coagulation factors in postmenopausal women.
Natural oestrogens "Premarin", (Ayerst, conjugated equine oestrogens) "Harmogen", (Abbott, piperazine oestrone sulphate) and "Progynova" (Schering, oestradiol valerate) alone and in combination with proestational agents such as "Primolut N", (Schering, norethisterone) "Neogest", (Schering, norgestrel), "Norgeston", (Schering, levonorgestrel), "Duphaston" (Duphar, dydrogesterone) did not have adverse effects on clotting factors. One patient developed deep vein thrombosis following treatment using "Progynova" (oestradiol valerate) alone and a second patient suffered from mild myocardial infarction following the use of "Premarin" (conjugated equine oestrogens) alone.
D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors; D001780:Blood Coagulation Tests; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D045166:Estradiol Congeners / Q000627:therapeutic use*; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D004970:Estrone / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D008593:Menopause; D008875:Middle Aged; D009640:Norethindrone / Q000627:therapeutic use; D009644:Norgestrel / Q000627:therapeutic use; D045167:Progesterone Congeners / Q000627:therapeutic use*; D013997:Time Factors
D001779:Blood Coagulation Factors; D003277:Contraceptives, Oral, Combined; D045166:Estradiol Congeners; D004966:Estrogens, Conjugated (USP); D045167:Progesterone Congeners; D004970:Estrone; D009644:Norgestrel; D004958:Estradiol; D016912:Levonorgestrel; C009927:estropipate; D009640:Norethindrone