title: Cytoprotection - organoprotection by somatostatin: gastric and hepatic lesions.
abstract: In rats, the hemorrhagic gastric erosions produced by ethanol, and the fatal hemorrhagic hepatic necrosis induced by phalloidin, were significantly reduced by regular somatostatin, but not by derivatives devoid of -SH containing cysteines. These effects of the hormone were abolished in animals which received, in addition, the sulfhydryl blocker n-ethylmaleimide before the toxic chemicals. Thus, somatostatin exhibits organoprotection dependent on endogenous sulfhydryls.
mesh_terms: D000818:Animals; D000431:Ethanol; D005033:Ethylmaleimide / Q000494:pharmacology; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy*; D008107:Liver Diseases / Q000188:drug therapy*; D010590:Phalloidine; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000627:therapeutic use*; D013272:Stomach Diseases / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000502:physiology
chemical_list: D013438:Sulfhydryl Compounds; D010590:Phalloidine; D000431:Ethanol; D013004:Somatostatin; D005033:Ethylmaleimide