title: Lack of effect of ranitidine on warfarin action.
abstract: 1 In five volunteers taking daily subtherapeutic doses of warfarin the addition of ranitidine 200 mg twice daily for 14 days did not affect prothrombin time or plasma warfarin concentration. 2 Ranitidine had no effect on the single dose pharmacodynamics and pharmacokinetics of warfarin in the rat. 3 Ranitidine had no effect on pentobarbitone sleeping time in the rat whereas cimetidine significantly prolonged the sleeping time. 4 The interaction between cimetidine and oral anticoagulants is unrelated to histamine H2-receptor antagonism.
mesh_terms: D000328:Adult; D000818:Animals; D004347:Drug Interactions; D005663:Furans / Q000494:pharmacology*; D006207:Half-Life; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D011517:Prothrombin Time; D011899:Ranitidine; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D014859:Warfarin / Q000097:blood / Q000494:pharmacology*
chemical_list: D005663:Furans; D006635:Histamine H2 Antagonists; D014859:Warfarin; D011899:Ranitidine; D010424:Pentobarbital