Effect of immunosuppression on morphological changes in CNS of monkeys infected with different measles virus vaccine strains.
Residual neurovirulence of measles virus vaccine strains "Leningrad-16", "Moscow-5" and of cloned variant of L-16 strain--clone 3, differing in the degree of attenuation, was studied in intracerebrally (i.c.) infected Cercopithecus aethiops monkeys, receiving cortisone and/or antilymphocyte serum (ALS). Whereas the sensitivity for detection of the potential neurovirulence of vaccine strains was not increased by cortisone treatment. ALS had such effect in detection of neurotropic properties of the L-16 strain and its cloned variants.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001921:Brain / Q000473:pathology*; D002522:Chlorocebus aethiops; D003348:Cortisone / Q000494:pharmacology; D004679:Encephalomyelitis / Q000473:pathology*; D007165:Immunosuppression Therapy; D008457:Measles / Q000276:immunology / Q000473:pathology*; D008458:Measles Vaccine; D008459:Measles virus / Q000472:pathogenicity*; D013116:Spinal Cord / Q000473:pathology*; D014613:Vaccines, Attenuated; D014774:Virulence / Q000187:drug effects
D000961:Antilymphocyte Serum; D008458:Measles Vaccine; D014613:Vaccines, Attenuated; D003348:Cortisone