Carotid wall as an isotropic mechanical system.
The morphological organization of the structural components in the dog carotid wall is investigated by X-ray diffraction and microscopic analysis. Histological analysis confirms an anisotropic morphology of smooth muscle cells and elastic fibers in the tissue. Collagen fibers, as revealed by X-ray diffraction technique, are organized in an isotropic network in the unstretched carotid media. Collagen fibers stretch without a preferential direction of orientation when a carotid segment is deformed in the physiological range under intraluminal pressure. A mathematical model which takes into account the isotropic distribution of the collagen fibers is developed. The validity of this model has been tested by computing several mechanical parameters using Anliker's data on the axial and radial oscillation obtained for carotids of living dogs. In spite of the anisotropic morphology of the main constituents of the carotid media layer, from a mechanical point of view the tissue can be considered as an isotropic material for the random distribution of the collagen fibers which represent the component of higher tensile strength.
D000818:Animals; D001696:Biomechanical Phenomena; D002339:Carotid Arteries / Q000033:anatomy & histology / Q000502:physiology*; D004285:Dogs; D004548:Elasticity; D008433:Mathematics; D008955:Models, Cardiovascular; D009131:Muscle, Smooth, Vascular / Q000033:anatomy & histology / Q000502:physiology*; D012212:Rheology; D014961:X-Ray Diffraction