[Physiological activity of polymethylene and polyoxyethylene bis-(2-amino-1,3-diazepiniuim) iodides].
A study was made of physiological activity of a series of new bisquaternary compounds in which the role of cation heads is played by the residues of 2-amino-1,3-diazepinium. Studies performed on a frog neuromuscular preparation showed that the compounds under test effectively block the responses of the postsynaptic membrane to acetylchinoline. The derivatives of diazepinium have pronounced hypotensive and ganglion-blocking properties. Octamethylene-bis-(2-amino-1,3-diazepinium) iodide that appeared to be the most effective of the compounds under test compares very favourably with benzohexonium. It was found to be 1.5 times more powerful as regards the ganglion-blocking and hypotensive activity.
D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D005730:Ganglionic Blockers / Q000494:pharmacology; D007421:Intestine, Small / Q000187:drug effects; D051379:Mice; D009132:Muscles / Q000187:drug effects; D011898:Ranidae; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D001381:Azepines; D005730:Ganglionic Blockers; D011950:Receptors, Cholinergic
Fiziologicheskaia aktivnost' polimetilen- o pilioksiétilen-bis- -(2-amino-1,3-diazepiniĭ)ĭodidov.