title: Effects of oral supplementation with stable strontium.
abstract: The biologic effects of stable strontium, a naturally occurring trace element in the diet and the body, have been little investigated. This paper discusses the effects of oral supplementation with stable strontium in laboratory studies and clinical investigations. The extent of intestinal absorption of various doses of orally administered strontium was estimated by determining serum and tissue levels with atomic absorption spectrophotometry. The central observation is that increased oral intake produces a direct increase in serum levels and intracellular uptake of strontium. The results of these studies, as well as those of other investigators, demonstrate that a moderate dosage of stable strontium does not adversely affect the level of calcium either in the serum or in soft tissues. In studies of patients receiving 1 to 1.5 g/d of strontium gluconate, a sustained increase in the serum level of strontium produced a 100-fold increase in the strontium:calcium ratio. In rats, studies indicate that an increase in intracellular strontium content following supplementation may exert a protective effect on mitochondrial structure, probably by means of a stabilizing effect of strontium on membranes. The strontium:calcium ratio in animals receiving a standard diet is higher in the cell than in the extracellular fluid; this may be of physiologic significance.An increase in density that corresponded to the deposition of stable strontium was observed in areas of bone lesions due to metastatic cancer in patients receiving stable strontium supplementation. This suggests the possibility of using strontium to mineralize osteophenic areas and to relieve bone pain. Also, because of reports of an inverse relation between the incidence of dental caries and a high strontium content in drinking water, the use of natural water containing relatively high levels of stable strontium should be considered. In each of these instances it is important to maintain a normal dietary intake of calcium.
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000188:drug therapy; D001842:Bone and Bones / Q000187:drug effects*; D002118:Calcium / Q000032:analysis / Q000097:blood; D002779:Cholestasis / Q000188:drug therapy; D003063:Cnidaria; D006801:Humans; D008099:Liver / Q000032:analysis; D008274:Magnesium / Q000097:blood; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D012623:Seawater / Q000032:analysis; D013324:Strontium / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D014867:Water / Q000032:analysis; D014881:Water Supply / Q000032:analysis
chemical_list: D014867:Water; D008274:Magnesium; D002118:Calcium; D013324:Strontium