title: The relation between tumor cell proliferation and vascularization in differentiated and undifferentiated colon carcinomas in the rat.
abstract: Tumor cell proliferation and tumor vascularization were investigated in differentiated and undifferentiated colon carcinomas of the rat. The following results were found: 1, in both tumor types, vascularization is developed equally well; 2, both in the differentiated and in the undifferentiated carcinomas, the number of proliferating tumor cells decreases with increasing distance from the capillaries; at a distance of about 80 microns, there is no longer any noteworthy tumor cell proliferation; 3, the differentiated and undifferentiated carcinomas differ both in the level of the mitosis index and 3H-thymidine labeling index as well as in their local proliferation pattern despite equal vascularization; 4, these differences must be based on factors which are independent of vascularization; they are attributed to proliferation properties which are inherent in the differently differentiated tumor cell populations. It is concluded from this that the actual proliferation behavior of a carcinoma is primarily dependent on the proliferation properties of the tumor cell population.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002455:Cell Division; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000473:pathology; D008940:Mitotic Index; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology; D051381:Rats; D013936:Thymidine / Q000378:metabolism
chemical_list: D013936:Thymidine