Self-administration of central stimulants by rats: a comparison of the effects of d-amphetamine, methylphenidate and McNeil 4612.
Rats were trained to press a lever for the intravenous administration of d-amphetamine. The rate of responding was decreased in a dose-dependent and time-related manner by non-contingent injections of d-amphetamine, methylphenidate or McNeil 4612. Methylphenidate and McNeil 4612 also maintained self-administration behavior when they were substituted for d-amphetamine, whereas substitution of saline for d-amphetamine resulted in extinction of the self-administration behavior. These data suggest that methylphenidate and McNeil 4612, like d-amphetamine, can act as reinforcers in rats.
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012646:Self Administration
D000697:Central Nervous System Stimulants; D007546:Isoquinolines; D008774:Methylphenidate; C041059:McN 4612; D003913:Dextroamphetamine