title: A comparative study of neurotensin inactivation by brain peptidases from different vertebrate species.
abstract: The products formed from mammalian neurotensin by peptidases in two subcellular fractions from rat, mouse, dove, terrapin and goldfish brain were separated and identified using high-performance liquid chromatography. The main neurotensin metabolites were [1-8]-, [1-10]- and [1-7]-sequences; goldfish and terrapin brain fractions also produced [1-11]- and [1-12]-fragments. Avian neurotensin was cleaved by peptidases in rat and dove brain fractions to [1-8]-, [9-13]-, [1-10]- and [1-12]-fragments. Similar mechanisms of inactivation were found for both mammalian and avian neurotensins .
mesh_terms: D000818:Animals; D001717:Birds / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D005260:Female; D006054:Goldfish / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009496:Neurotensin / Q000378:metabolism*; D011894:Rana pipiens / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013347:Subcellular Fractions / Q000378:metabolism; D014426:Turtles / Q000378:metabolism
chemical_list: D009496:Neurotensin; D010450:Endopeptidases