Compartment model of prenalterol.
In previous pharmacokinetic studies in healthy subjects the time course of plasma concentration of prenalterol was described by a short distribution phase (alpha-phase) with a mean half-life of about 8 minutes and an elimination phase (beta-phase) with an average half- life of about two hours [1, 2]. The aim of this joint study was to check the pharmacokinetic data obtained after intravenous single dose administration with the computer program TOPFIT [3] using different compartment models and to test the predictive power of the chosen kinetic model for plasma concentration data after repetitive intravenous prenalterol dosing.
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D003201:Computers; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D011217:Practolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D011294:Prenalterol; D013223:Statistics as Topic; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D011294:Prenalterol; D011217:Practolol