Effects of streptozotocin-diabetes and L-thyroxine treatment on TSH and GH, and circulating glucose and glycerol in thyroidectomized rats.
The response to exogenous thyroxine in thyroidectomized rats made diabetic by treatment with streptozotocin was greatly impaired, as shown by their growth retardation and the lack of increase in plasma GH and pituitary GH and TSH concentrations. Insulin administration partially compensated for these endocrine alterations in diabetic thyroidectomized rats. When these animals received enough exogenous thyroxine to normalize their plasma PBI and TSH levels, insulin administration did not decrease their augmented glucose and glycerol concentrations. These findings show the permissive action between thyroid hormones and insulin although some effects of the former counteract those of insulin.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000150:complications; D005990:Glycerol / Q000097:blood; D013006:Growth Hormone / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood* / Q000150:complications; D008297:Male; D051381:Rats; D013972:Thyrotropin / Q000097:blood*
D001786:Blood Glucose; D013972:Thyrotropin; D013006:Growth Hormone; D005990:Glycerol