Phenoxybenzamine antagonizes somatostatin-induced antiamnesia in rats.
The effects of pretreatment with atropine, haloperidol and phenoxybenzamine on somatostatin-induced antiamnesia were investigated. Somatostatin itself blocked electroconvulsive shock (ECS)-induced amnesia. The receptor blockers per se had no influence on the ECS-induced avoidance latency. Atropine and haloperidol did not inhibit somatostatin-induced antiamnesia, whereas phenoxybenzamine blocked it completely. The results suggest that the central noradrenergic system plays an important role in the mediation of the antiamnesic action of somatostatin.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004597:Electroshock; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D010643:Phenoxybenzamine / Q000494:pharmacology*; D051381:Rats; D013004:Somatostatin / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D010643:Phenoxybenzamine; D013004:Somatostatin; D001285:Atropine; D006220:Haloperidol