Enhancement of hemopoietic stem cell proliferation by prostaglandin inhibitory drugs.
The in vivo effect of several prostaglandin inhibitory drugs on the hemopoietic stem cell was studied in SJL/J mice. Repeated intramuscular administration of Indomethacin increased the total number of bone marrow (BM) and spleen pluripotent hemopoietic stem cells (CFUS). The number of spleen colonies in lethally-irradiated normal BM recipients, which had been treated with Indomethacin, Aspirin or Flufenamic acid (all prostaglandin inhibitory drugs), was significantly greater than controls' spleen colonies. After exposure of SJL/J mice to different amounts of irradiation, more endogenous spleen colonies and a greater splenic weight were found among mice which had been treated with Indomethacin in comparison to PBS-treated mice. According to our results, treatment with prostaglandin inhibitory drugs stimulates murine hemopoietic stem cell proliferation and enhances stem cell recovery following irradiation.
D000082:Acetaminophen / Q000008:administration & dosage; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage; D016026:Bone Marrow Transplantation; D005260:Female; D005439:Flufenamic Acid / Q000008:administration & dosage; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D011448:Prostaglandin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D011828:Radiation Chimera; D013154:Spleen / Q000033:anatomy & histology
D011448:Prostaglandin Antagonists; D000082:Acetaminophen; D005439:Flufenamic Acid; D001241:Aspirin; D007213:Indomethacin