Cholecystokinin octapeptide levels in rat brain are changed after subchronic neuroleptic treatment.
Cholecystokinin octapeptide sulfate (CCK-8-S), nonsulfated cholecystokinin octapeptide (CCK-8-NS) and cholecystokinin tetrapeptide (CCK-4) levels in rat brain were measured by a combination of high pressure liquid chromatography (HPLC) and radioimmunoassay (RIA) after acute and subchronic treatment of the animals with haloperidol. CCK levels did not change after acute treatment. However, CCK-8-S concentrations were increased in the striatum and the mesolimbic system after two weeks of haloperidol treatment and remained increased after four weeks of haloperidol treatment. A transient decrease in CCK-8-S concentrations was observed in the cortex. Treatment with chlorpromazine or clozapine gave similar results. No changes in CCK-8-NS or CCK-4 concentrations were seen in any of the experiments.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D002766:Cholecystokinin / Q000378:metabolism*; D003024:Clozapine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000378:metabolism; D013758:Tetragastrin / Q000378:metabolism
D014150:Antipsychotic Agents; D013758:Tetragastrin; D002766:Cholecystokinin; D003024:Clozapine; D006220:Haloperidol; D012844:Sincalide; D002746:Chlorpromazine