Presence of N-methyl-D-aspartate-like and kainate-like activities in bovine brain.
Searching for the natural ligands interacting with brain excitatory amino acid receptors, we have isolated from cow brain a low-Mr ampholyte fraction containing molecules with excitatory properties similar to those of N-methyl-D-aspartate and kainate, which cannot be accounted for by any of the known brain excitants. This finding supports the hypothesis of the existence of excitatory neurotransmitters other than L-glutamate and L-aspartate.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D001923:Brain Chemistry; D002250:Carbon Radioisotopes; D002417:Cattle; D005971:Glutamates / Q000032:analysis; D018698:Glutamic Acid; D007608:Kainic Acid / Q000032:analysis*; D016202:N-Methylaspartate; D018377:Neurotransmitter Agents / Q000032:analysis*; D011759:Pyrrolidines / Q000032:analysis*
D002250:Carbon Radioisotopes; D005971:Glutamates; D018377:Neurotransmitter Agents; D011759:Pyrrolidines; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D007608:Kainic Acid