title: Effect of desferrioxamine on removal of aluminum and iron by coated charcoal haemoperfusion and haemodialysis.
abstract: An intravenous infusion of desferrioxamine (3 g) was given to 17 chronic renal failure patients stabilised on standard haemodialysis. Aluminium clearance 48 h after desferrioxamine was 65.3 +/- 11.0 ml/min for 'Dialaid 4000' with 70 g coated charcoal haemoperfusion system; 44.6 +/- 13.7 ml/min for 'Rhondial 75' with polyacrylonitrate membrane; 35.8 +/- 11.0 ml/min for 'Monitral' with polyacrylonitrate membrane; and 4.0 +/- 17.8 ml/min for haemodialysers with a 'Cupraphane' membrane. None of these 4 systems removed any aluminium in the absence of desferrioxamine in the same patients. Even at a desferrioxamine concentration of 40 mg/dl, coated activated charcoal (CAC) was not saturated. CAC did not absorb ferric ions in vitro. But when 40 mg/dl of desferrioxamine was present CAC absorbed increasing concentrations of ferric ions in a linear fashion.
mesh_terms: D000327:Adsorption; D000535:Aluminum / Q000378:metabolism*; D002606:Charcoal; D002986:Clinical Trials as Topic; D003676:Deferoxamine / Q000494:pharmacology*; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000628:therapy; D006435:Renal Dialysis / Q000379:methods
chemical_list: D002606:Charcoal; D000535:Aluminum; D007501:Iron; D003676:Deferoxamine