Receptors for bradykinin in murine peritoneal macrophages: modulation of short-term spreading.
The order of potency of bradykinin (bk) and four analogues, with respect to their modulation of peritoneal macrophage short-term spreading, suggests the presence of two peptide receptors in these cells which are responsible for antagonistic effects. Spreading inhibition and stimulation are mediated by the B1- and B2-types respectively. The implications of these results are highlighted in view of the hypothesis that the anti-inflammatory compound of the 1500--1000 molecular weight peptide fraction purified from malignant cell culture supernatants could be a kinin metabolite and a feedback mediator of inflammatory reactions.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008970:Molecular Weight; D018002:Receptors, Bradykinin; D011956:Receptors, Cell Surface / Q000378:metabolism*
D018002:Receptors, Bradykinin; D011956:Receptors, Cell Surface