Detection by radioimmunoassay of antigens related to the P30 polypeptides of primate type C oncoviruses in peripheral leukocytes from patients with chronic myelogenous leukaemia.
Leukocytes from patients with chronic myelogenous leukaemia were examined for antigens related to the p30 polypeptides of baboon endogenous virus (BaEV) and gibbon ape leukaemia virus (GaLV). Samples from patients with the quiescent phase of the disease proved to be negative or contained p30 of BaEV as the only viral antigen. In cases of blastoid crisis or acceleration, an antigen related to p30 of GaLV could be detected. In 5 of 6 patients, acceleration or blastoid crisis was preceded by expression of GaLV p30.
D000956:Antigens, Viral / Q000032:analysis*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*; D007962:Leukocytes / Q000276:immunology*; D011863:Radioimmunoassay; D012190:Retroviridae / Q000276:immunology*; D014758:Viral Core Proteins; D014764:Viral Proteins / Q000276:immunology*
D000956:Antigens, Viral; D014758:Viral Core Proteins; D014764:Viral Proteins