Antimicrobial activity of topical beta-adrenergic blocking agents.
Three topical beta-adrenergic blocking agents without preservatives were tested for their ability to inhibit the growth of five microorganisms in vitro. Timolol maleate and befunolol hydrochloride showed no antimicrobial activity; however, bupranolol hydrochloride inhibited microbial growth. The minimum inhibitory concentration of bupranolol hydrochloride was 0.1% for Bacillus subtilis and 0.05% for Staphylococcus aureus and Escherichia coli.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002046:Bupranolol / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D066298:In Vitro Techniques; D011412:Propanolamines / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013999:Timolol / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C006034:befunolol; D013999:Timolol; D002046:Bupranolol