Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during, and after cimetidine treatment.
Eight healthy subjects were studied half-hourly or hourly for 24 h periods before, during, and after cimetidine treatment. No significant differences in intragastric bacterial counts or bacterial species or in intragastric nitrite or N-nitroso-compound concentrations were found as a result of cimetidine treatment. Bacterial counts and nitrite concentrations tended to increase with pH, but N-nitroso-compound concentrations did not. This study provides no evidence that cimetidine treatment may increase the risk of gastric carcinoma by raising N-nitroso-compound concentrations.
D001419:Bacteria / Q000187:drug effects / Q000378:metabolism*; D002927:Cimetidine / Q000494:pharmacology*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism*; D009603:Nitroso Compounds / Q000378:metabolism*
D006146:Guanidines; D009566:Nitrates; D009573:Nitrites; D009603:Nitroso Compounds; D002927:Cimetidine