Polybrominated biphenyls as promoters in experimental hepatocarcinogenesis in rats.
Female Sprague Dawley rats were fed polybrominated biphenyls (PBB) for six months after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if PBB could serve as a tumor promoter in a two stage hepatocarcinogenesis test system. Firemaster BP-6, a commercial mixture of PBB, and its major congener, 2,2',4,4',5,5'-hexabromobiphenyl (HBB) were used in this study. Tumor promoting ability was assessed by measuring enzyme altered foci exhibiting gamma glutamyl transpeptidase activity. Dietary concentrations of 10 and 100 p.p.m. of the mixture of PBB and of HBB were found to be promoters of hepatocarcinogenesis. The mixture of PBB had a greater tumor promoting ability than HBB.
D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D002273:Carcinogens; D004052:Diethylnitrosamine; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008113:Liver Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010634:Phenobarbital / Q000494:pharmacology; D011075:Polybrominated Biphenyls / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011503:Transglutaminases
D001713:Biphenyl Compounds; D002273:Carcinogens; D011075:Polybrominated Biphenyls; D004052:Diethylnitrosamine; D000217:Acyltransferases; D011503:Transglutaminases; D010634:Phenobarbital