title: Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
abstract: Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects; D001284:Atrophy; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D004298:Dopamine / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000134:cerebrospinal fluid*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D008875:Middle Aged; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D051381:Rats; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D014057:Tomography, X-Ray Computed
chemical_list: D014150:Antipsychotic Agents; D010648:Phenylacetates; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine; D006719:Homovanillic Acid