[Effect of parasympathetic agents on renin secretion in vitro].
A study was made of the effect of the parasympathetic agents on renin secretion by rat kidney sections after blockade of alpha- and beta-adrenoreceptors by obsidan and dihydroergotamine. The substances under study were administered at the concentrations 10(-8), 10(-6) or 10(-4) M. Renin activity was determined by radioimmunoassay. n-Cholinomimetics (nicotine, cytiton) were discovered to have a marked inhibitory action on renin secretion, reducing it to almost zero at a concentration of 10(-4) M. n-Cholinolytics (spasmolytin, benzohexonium) produced a dose-dependent stimulation of renin secretion with a 10-20-fold maximal increase. m-Cholinomimetics (aceclidin, proserin) and quateron provoked a 3-5-fold increase in secretion without a dose-dependent effect, whereas galanthamine exerted a negligible effect. Pilocarpine and m-cholinolytics (platyphylline, atropine) reduced the secretion by 2 times without a dose-dependent effect. It is assumed that the renal cortex contains n-cholinoreactive systems that have a direct or mediated action on renin secretion and m-cholinoreactive systems that modulate the activity of the former systems.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004158:Diphenylacetic Acids / Q000494:pharmacology; D005702:Galantamine / Q000494:pharmacology; D005730:Ganglionic Blockers / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D009388:Neostigmine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology; D051381:Rats; D012083:Renin / Q000378:metabolism*
D004158:Diphenylacetic Acids; D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D010276:Parasympatholytics; D010277:Parasympathomimetics; D011763:Pyrrolizidine Alkaloids; D000644:Quaternary Ammonium Compounds; D011812:Quinuclidines; D010862:Pilocarpine; D005702:Galantamine; C008342:quateron; D009388:Neostigmine; D001285:Atropine; C008937:platyphylline; D012083:Renin; C021628:benzohexonium
Vozdeĭstviia parasimpaticheskikh agentov na sekretsiiu renina in vitro.