title: Short-term and long-term effects of ranitidine and oxmetidine on gastrointestinal motility in sheep.
abstract: Short-term and specific motor effects of ranitidine on gastrointestinal motility of conscious sheep were recorded. These effects were prevented by atropine, but tachyphylaxis was observed after a second injection. Short-term effects on motility were not obtained with oxmetidine. Long-term effects for both ranitidine and oxmetidine, at high doses, were reducing the frequency of reticular contractions and shortening the interval between MMCs in a similar manner.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004347:Drug Interactions; D004386:Duodenum / Q000187:drug effects; D004576:Electromyography; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology*; D012756:Sheep; D013997:Time Factors
chemical_list: D006635:Histamine H2 Antagonists; D007093:Imidazoles; D001285:Atropine; D011899:Ranitidine; C027703:oxmetidine