[Role of adrenergic receptors in the mechanism of action of catecholamines and DOPA on proliferative processes].
Catecholamines (adrenaline, isoproterenol) and L-DOPA decreased the mitotic index of L-cells in culture. The action of catecholamines was blocked by the beta-adrenergic antagonist propranolol, but was not abolished by the alpha-adrenoblocker phenoxybezamine. The L-DOPA-induced decrease in the mitotic index did not depend on the pretreatment with the adrenoblockers. Catecholamines inhibited the incorporation of 3H-thymidine and 3H-leucine into DNA and total protein of the cells, respectively. Preincubation of the culture with propranolol for 10-20 minutes before catecholamine administration prevented the action of catecholamines. Phenoxybenzamine, an alpha-adrenoreceptor blocker, did not produce such an effect. The data obtained point to the leading role of beta-adrenoreceptors in the mechanism of the effects of catecholamines on proliferative processes. The action of L-DOPA on cell proliferation does not seem to be linked with adrenoreceptor activation.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects*; D007980:Levodopa / Q000494:pharmacology*; D051379:Mice; D008940:Mitotic Index / Q000187:drug effects; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011941:Receptors, Adrenergic; D010643:Phenoxybenzamine; D007980:Levodopa; D011433:Propranolol; D007545:Isoproterenol; D004837:Epinephrine
Rol adrenergicheskikh retseptorov v mekhanizme vliianiia katekholaminov i DOFA na proliferativnye protsessy.