Altered ocular absorption and disposition of sodium cromoglycate upon ion-pair and complex coacervate formation with dodecylbenzyldimethylammonium chloride.
Ion-pair formation between the dianionic drug sodium cromoglycate and dodecylbenzyldimethylammonium chloride has been found to alter the extent and rate of corneal penetration of both large ions upon their coadministration. Additionally, using a complex coacervate of the two large ions as the applied dose form (in which the complex is in equilibrium with the ion pairs), a change in the overall disposition of both large ions to the various components of the eye is observed.
D000042:Absorption; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001548:Benzalkonium Compounds / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002626:Chemistry, Pharmaceutical; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000378:metabolism*; D005123:Eye / Q000378:metabolism*; D005260:Female; D007477:Ions; D011817:Rabbits; D013501:Surface-Active Agents / Q000008:administration & dosage*
D001548:Benzalkonium Compounds; D007477:Ions; D013501:Surface-Active Agents; C015163:dimethyldodecylbenzylammonium; D004205:Cromolyn Sodium