title: Effect of opiate analgesia and opioid blockade on urethral mucosal sensitivity threshold.
abstract: The effect of opiate analgesics (omnopon, pethidine, pentazocine) on the urethral mucosal sensitivity threshold in 37 patients, and of the potent opiate/opioid antagonist naloxone on 10 volunteers is described. Omnopon and pentazocine caused a significant decrease in sensitivity (p less than 0.02) and naloxone caused a significant increase in sensitivity (p less than 0.02). The results confirm a role for the endogenous opioids in modulating urethral sensitivity, and the implications of this are discussed.
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D004723:Endorphins / Q000037:antagonists & inhibitors* / Q000502:physiology; D006801:Humans; D008297:Male; D008614:Meperidine / Q000494:pharmacology; D009092:Mucous Membrane / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D009892:Opium / Q000494:pharmacology; D010423:Pentazocine / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects; D012677:Sensation / Q000187:drug effects*; D012684:Sensory Thresholds / Q000187:drug effects; D014521:Urethra / Q000187:drug effects*; D014563:Urodynamics
chemical_list: D000701:Analgesics, Opioid; D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D009892:Opium; D008614:Meperidine; D010423:Pentazocine