[Immunohistochemical localization of inducible tyrosine aminotransferase isoenzyme in the cells of the normal rat liver and in hydrocortisone induction].
Using immunofluorescent technique, a soluble antigen--hydrocortisone induced isoenzyme of tyrosineaminotransferase--was localized in sections of the intact rat liver. Tyrosineaminotransferase was not detected in all the hepatocytes. 5 hours following hydrocortisone  to rats, the intensity of specific fluorescence that characterizes trosineaminotransferase activity in hepatocytes, was found to increase, and clearly outlined zones of entire fluorescence were seen in the liver sections. The data obtained are discussed in terms of hormonal induction mechanisms.
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D004790:Enzyme Induction / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006854:Hydrocortisone / Q000494:pharmacology*; D007114:Immunization; D007122:Immunoelectrophoresis; D007527:Isoenzymes / Q000032:analysis / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014444:Tyrosine Transaminase / Q000032:analysis / Q000096:biosynthesis*
D007527:Isoenzymes; D014444:Tyrosine Transaminase; D006854:Hydrocortisone
Immunogistokhimicheskaia lokalizatsiia indutsibel'nogo izofermenta tirozinaminotransferazy v kletkakh pecheni krysy v norme i pri induktsii gidrokortizonom.