Binding of Phenothiazines to bovine hemoglobin.
Phenothiazines with bovine hemoglobin give solid complexes in phosphate buffer; this is due to the presence of ion-pairs between phenothiazines and phosphates. Using diluted solutions the number of sites available on each protein molecule and the intrinsic binding constants are determinated; the number of sites, in solutions and in solid complexes, is about the same for each drug, but different for the various phenothiazines.
D000818:Animals; D014150:Antipsychotic Agents / Q000097:blood*; D002417:Cattle; D003956:Dialysis; D004058:Diffusion; D006454:Hemoglobins / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D010640:Phenothiazines; D011485:Protein Binding
D014150:Antipsychotic Agents; D006454:Hemoglobins; D010640:Phenothiazines