title: The effect of histamine stimulation and H2 -receptor inhibition on the pituitary prolactin and ACTH release and on cortisol secretion in human males.
abstract: The effects of histamine (HA) on prolactin (PRL), ACTH, and cortisol secretion in human males were investigated. Specific H2 -receptor blockade caused an immediate and significant PRL release, while specific H2 -receptor stimulation (HA and mepyramine) was without effect on PRL secretion. HA significantly stimulated both ACTH and cortisol secretion, and this stimulation was probably mediated through H2 -receptors, H2 -receptor blockade caused a late, but significant ACTH release. This release was not accompanied by a release of cortisol, and might therefore be due to a spontaneous oscillation in ACTH secretion. The results support the theory that HA acts as a modulator of human ACTH secretion. A similar effect on PRL secretion as postulated by others could not be confirmed in this study.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D000368:Aged; D005663:Furans / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D011738:Pyrilamine / Q000494:pharmacology; D011899:Ranitidine
chemical_list: D005663:Furans; D006635:Histamine H2 Antagonists; D006632:Histamine; D011899:Ranitidine; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D011738:Pyrilamine; D006854:Hydrocortisone