title: [Mineralocorticoid function of the adrenal glands in adolescents with primary arterial hypertension before and after treatment with beta-blocking agents].
abstract: A study of adrenal mineral corticoid function in adolescents with primary arterial hypertension, stage Ib, revealed hyperaldosteronism in more than half of the patients (57%). Treatment with beta-blocking agents (anaprilin and obsidan) was only effective (producing a drop in arterial pressure) in patients with initial high plasma aldosterone levels. beta-blocking agents administered to patients with normal blood aldosterone content did not result in arterial pressure change (failure of treatment). The results obtained suggest that the effect of beta-blocking agents on adrenal mineral corticoid activity in adolescent patients with primary arterial hypertension depends on its baseline level; they are also indicative of a dependence of the hypotensive effect of beta-adrenoreceptor blockers on the state of mineral corticoid function.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000302:Adrenal Cortex / Q000503:physiopathology*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000336:Aerosols; D000450:Aldosterone / Q000097:blood* / Q000652:urine; D002648:Child; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000319:Adrenergic beta-Antagonists; D000336:Aerosols; D000450:Aldosterone; D006854:Hydrocortisone
vernacular_title: Sostoianie mineralokortikoidnoĭ funktsii nadpochechnikov u podrostkov s pervichnoĭ arterial'noĭ gipertoniei do i posle lecheniia beta-blokatorami.