Effect of hyperbaric oxygenation on experimental scrapie in mice.
The effect of hyperbaric oxygenation upon experimental infection of BALB/c mice with the scrapie agent was investigated by virological methods, histology and electron microscopy. A multiple exposure of scrapie-infected mice to hyberbaric oxygenation during the incubational period led to a certain aggravation of infection as evidenced by a greater accumulation of the agent in the central nervous system (CNS) and spleen, as well as by more pronounced ultramicroscopic changes in CNS. A single exposure to hypoxia failed to alter any manifestations of infection.
D000818:Animals; D001921:Brain / Q000473:pathology; D006931:Hyperbaric Oxygenation; D000860:Hypoxia; D051379:Mice; D008807:Mice, Inbred BALB C; D012608:Scrapie / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D012756:Sheep; D013154:Spleen / Q000473:pathology