Effects of gamma-aminobutyric acid on insulin, glucagon, and somatostatin release from isolated perfused dog pancreas.
The effects of gamma-aminobutyric acid (GABA) on the secretion of insulin, glucagon, and somatostatin were studied in the isolated dog pancreas. Insulin secretion was inhibited in a dose-related fashion for 10 min or more by as little as 1 microM GABA. A prompt but small and transitory rise in somatostatin secretion, lasting only 1 min, occurred at GABA concentrations of 10 and 100 microM, levels that exert inhibitory effects on nervous tissue. Bicuculline, a GABA antagonist, inhibited insulin secretion and did not antagonize GABA-mediated insulin inhibition. The results suggest that GABA in concentrations that are known to exist in islet tissue can influence the secretion of islet hormones.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004285:Dogs; D005934:Glucagon / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D013004:Somatostatin / Q000378:metabolism*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D007328:Insulin; D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D005934:Glucagon; D001640:Bicuculline