title: [Urinary enzyme excretion in cephalothin therapy in adults and children].
abstract: A damage of the kidney, particularly of proximal tubular cells, can be indicated by an increased concentration of definite enzymes in urine. After gynecological operation the repeated application of 8 g cephalothin daily provokes an higher increase of enzyme concentrations in urine than the application of ampicillin under the same conditions. These results show that cephalothin produces a slight alteration of tubular cells, probably without practical importance. In contrast to this, in children a total dose of 1.5 up to 6 g cephalothin, administered after an operative correction of vesikoureterale reflux, provokes no marked changes in urinary enzyme excretion. Probably, in these children the determination of urinary enzyme excretion is not a suitable parameter to demonstrate a slight tubulotoxic damage.
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000652:urine; D000626:Aminopeptidases / Q000652:urine; D000667:Ampicillin / Q000009:adverse effects / Q000627:therapeutic use; D018826:CD13 Antigens; D002512:Cephalothin / Q000009:adverse effects* / Q000627:therapeutic use; D004798:Enzymes / Q000652:urine*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D007931:Leucyl Aminopeptidase / Q000652:urine; D008871:Microvilli / Q000187:drug effects; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000517:prevention & control; D005723:gamma-Glutamyltransferase / Q000652:urine
chemical_list: D004798:Enzymes; D000667:Ampicillin; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; D018826:CD13 Antigens; D002512:Cephalothin
vernacular_title: Harnenzymausscheidung während einer Therapie mit Cephalothin bei Erwachsenen und Kindern.