Declining T-cell immunity to influenza, 1977-82.
Influenza-A-virus-specific, HLA-restricted, cytotoxic T-cell immunity, measured in 189 volunteers in the six years 1977-82, showed a sharp decline from 1978. It is shown that natural infection with influenza-A virus boosts cytotoxic T-cell memory. The decline in T-cell immunity is probably associated with the low prevalence of influenza-A-virus infection since 1978.
D000293:Adolescent; D000328:Adult; D003602:Cytotoxicity, Immunologic; D004739:England; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D009980:Influenza A virus / Q000276:immunology; D007251:Influenza, Human / Q000266:history / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*