Plasma cholinesterase levels following pancuronium and vecuronium.
Plasma cholinesterase levels were measured in 52 patients following administration of pancuronium 1 mg/70 kg (10 patients) and 0.1 mg/kg (10 patients) and vecuronium in doses of 1 mg/70 kg (10 patients), 0.1 mg/kg (10 patients) and 0.2 mg/kg (12 patients). Both doses of pancuronium produced a significant (P less than 0.05 - less than 0.005) reduction in the enzyme levels. Vecuronium in a dose of 1 mg/70 kg was without any significant effects but the two higher doses produced a dose-related reduction of about 8 and 16% in the enzyme levels, respectively, which was statistically significant (P less than 0.05 - less than 0.001).
D000769:Anesthesia, Inhalation; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000097:blood*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D010197:Pancuronium / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D011229:Preanesthetic Medication; D013997:Time Factors; D014673:Vecuronium Bromide
D002800:Cholinesterase Inhibitors; D009125:Muscle Relaxants, Central; D014673:Vecuronium Bromide; D002802:Cholinesterases; D010197:Pancuronium