title: Ha-117 and Ha-118 are potent dopamine receptor agonists.
abstract: In-vitro studies evaluated the presynaptic dopamine receptor activities of trans-N-propyl-7,9-dihydroxyoctahydrobenzo[f]quinoline (Ha-117) and trans-N-ethyl-7,9-dihydroxyoctahydrobenzo[f]quinoline (Ha-118) using isolated field-stimulated cat right atria. Ha-117 and Ha-118 were found to be potent dopamine receptor agonists since their effects were antagonized by haloperidol. Compounds were inactive on presynaptic alpha 2-adrenoceptors using rat vas deferens and guinea-pig ileum. Results show that both resorcinol derivatives of octahydrobenzo[f]quinoline are potent dopamine receptor agonists without having presynaptic alpha 2-adrenoceptor stimulating activity.
mesh_terms: D000316:Adrenergic alpha-Agonists; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D006168:Guinea Pigs; D006220:Haloperidol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D000316:Adrenergic alpha-Agonists; D011804:Quinolines; D011954:Receptors, Dopamine; C041540:Ha 118; C041539:Ha 117; D006220:Haloperidol