H1-histaminergic activation stimulates phosphatidylinositol labeling in rabbit aorta.
Histamine and 2-(2-aminoethyl)-thiazole induced dose-dependent increases in the labeling of phosphatidylinositol in rabbit aorta whereas impromidine was without effect. The effect of histamine was inhibited by antihistamines with the following order of potency: mepyramine greater than or equal to pyrilamine much greater than cimetidine. The data indicate that H1-histaminergic activation stimulates phosphatidylinositol labeling in rabbit aorta and suggest the involvement of a calcium-signaling process in the action of H1-histaminergic receptors.
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D017446:Impromidine; D010716:Phosphatidylinositols / Q000378:metabolism*; D011817:Rabbits; D011968:Receptors, Histamine / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology; D013844:Thiazoles / Q000494:pharmacology
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D007093:Imidazoles; D010716:Phosphatidylinositols; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D013844:Thiazoles; C029345:2-(2-aminoethyl)thiazole; D006632:Histamine; D017446:Impromidine