title: Effect of a highly purified hyaluronidase preparation (GL enzyme) on electrocardiographic changes in acute myocardial infarction.
abstract: A highly purified preparation of hyaluronidase (GL enzyme) was given in a double-blind, placebo-controlled, randomised study to 192 consecutive patients within 12 h of suspected myocardial infarction. Compared with those receiving placebo, patients with definite myocardial infarction given GL enzyme had significantly less change in QRS complexes; in those with anterior infarction the development of Q waves was less prominent. At 4 months the overall mortality among those with definite and possible myocardial infarction receiving GL enzyme (6 out of 83 patients, 7.2%) was lower than that in those receiving placebo (11 out of 79, 14%); this difference was not significant. No adverse effects were observed.
mesh_terms: D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004562:Electrocardiography; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D011897:Random Allocation
chemical_list: D006821:Hyaluronoglucosaminidase