The beta-adrenergic receptor in heart failure.
Although the role of the autonomic nervous system in the pathophysiology of heart failure has been studied for decades, only within the past few years have adrenergic receptors and their alterations occupied center stage. There is now considerable evidence linking such receptors to many of the phenomena of heart failure; recent work appears to have significant therapeutic implications.
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology; D001665:Binding Sites / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000502:physiology; D011485:Protein Binding / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000032:analysis / Q000187:drug effects / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000187:drug effects / Q000502:physiology*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D008024:Ligands; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine