Implication of iron in seizure syndrome of mutant chicks (Gallus domesticus).
1. An investigation was made of systemic iron in paroxysmal (px) chicks. 2. Serum transferrin levels in px chicks are greatly increased (P less than 0.05) over control levels, but iron-binding capacity is decreased (P less than 0.05). 3. The delayed (by 10 days) increase in px hemoglobin (P less than 0.01) may be due to the general debilitation seen in px syndrome. 4. An attempt to determine brain iron showed no deposits comparable to mammalian brain iron distribution, but this was consistent with inability of others to locate iron in adult chicken brain tissue.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002645:Chickens; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D008297:Male; D009154:Mutation; D012640:Seizures / Q000235:genetics / Q000503:physiopathology*; D013577:Syndrome; D014168:Transferrin / Q000378:metabolism*
D001798:Blood Proteins; D006454:Hemoglobins; D014168:Transferrin; D007501:Iron