A comparison of the psychotropic profiles of tofisopam and diazepam.
Twelve normal subjects were tested on a number of measures both before and 1,3 and 5 h after 10 mg diazepam, 100 and 200 mg tofisopam and a placebo. The measures included self-ratings of mood, bodily symptoms, hostility and sleep, the electroencephalogram (EEG), reaction time, tapping, digit symbol substitution, the symbol copying test, and plasma levels. Diazepam showed a clear profile of action, producing EEG changes, pronounced sedation and psychological impairment. The last two effects were maximal at 1 h and had worn off by 5 h. The EEG was recorded at 3 h only. Tofisopam in no way resembled diazepam. It produced no changes on the EEG or psychological tests and a very mild stimulant effect was apparent on the ratings. While diazepam was easily detectable in the blood, tofisopam did not bind to benzodiazepine receptors.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000097:blood / Q000494:pharmacology*; D001569:Benzodiazepines / Q000097:blood / Q000494:pharmacology*; D003975:Diazepam / Q000097:blood / Q000494:pharmacology*; D004569:Electroencephalography; D004644:Emotions / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
D014151:Anti-Anxiety Agents; D011619:Psychotropic Drugs; D001569:Benzodiazepines; D003975:Diazepam; C012582:tofisopam