Behavioral and electrophysiological manifestations of bombesin: excessive grooming and elimination of sleep.
The effect of bombesin, applied intraventricularly in the rat, was examined with regard to the central control of behavior and arousal. Infusion of 1.0 micrograms bombesin produced stereotypic grooming activity and completely eliminated observable sleep. EEG frequency analysis confirmed the absence of sleep and demonstrated normal waking patterns during behavioral stereotypy. These results support a possible physiologic function for bombesin-like peptides in grooming and the sleep-waking cycle.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000187:drug effects; D001839:Bombesin / Q000494:pharmacology*; D004569:Electroencephalography; D006120:Grooming / Q000187:drug effects*; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D013004:Somatostatin / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*
D010455:Peptides; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D001839:Bombesin