Chromosomal breakage in multiple endocrine adenomatosis (types I and II).
Chromosomal analyses of cultured lymphocytes from nine patients with familial multiple endocrine adenomatosis (MEA) syndrome type I from six families and two patients - father and daughter - with familial MEA syndrome type II showed an increased frequency of chromosomal breakage. The frequency of sister chromatid exchanges was not increased.
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D009377:Multiple Endocrine Neoplasia / Q000235:genetics* / Q000473:pathology; D010375:Pedigree