Drug metabolism in adult white leghorn hens--response to enzyme inducers.
1. Adult hens were given a mixture of polychlorinated biphenyls (0.5 and 2 g/kg Aroclor 1254), 3-methylcholanthrene (80 mg/kg) or beta-napthoflavone (80 mg/kg). 2. beta-Napthoflavone elevated activities of both microsomal and nonmicrosomal enzymes 48 hr after dosing, with cytochrome P-450 p-nitroanisole O-demethylase, aniline hydroxylase, and glutathione S-epoxytransferase at 319% +/- 25, 157% +/- 12, 410% +/- 26 and 120% +/- 3 of control values, respectively. 3. Aroclor 1254 and 3-methylcholanthrane also elevated microsomal enzyme activities, but did not increase the activity of glutathione S-epoxytransferase. 4. Drug metabolizing capability in control and experimental hens differed from that in rats and mice.
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001140:Aroclors / Q000378:metabolism*; D001571:Benzoflavones / Q000378:metabolism*; D002645:Chickens / Q000378:metabolism*; D020111:Chlorodiphenyl (54% Chlorine); D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005419:Flavonoids / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D008297:Male; D008748:Methylcholanthrene / Q000378:metabolism*; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010090:Oxidoreductases, O-Demethylating / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000378:metabolism*; D051381:Rats; D019324:beta-Naphthoflavone
D001140:Aroclors; D001571:Benzoflavones; D005419:Flavonoids; D020111:Chlorodiphenyl (54% Chlorine); D008748:Methylcholanthrene; D019324:beta-Naphthoflavone; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D010090:Oxidoreductases, O-Demethylating; D000815:Aniline Hydroxylase; D005982:Glutathione Transferase