Depletion of striatal somatostatin by local cysteamine injection.
Local injection of cysteamine into rat striatum resulted in a dose-dependent reduction in somatostatin-like immunoreactivity (SLI). The effect was seen at 1 h, and persisted for up to 72 h, but was reversible at 1 week. The maximal depletion of SLI was approximately 50%. Histologic damage was largely confined to the needle tract. Of interest was a depletion of SLI in the contralateral striatum beginning at 3 h and maximal at 72 h. Cysteamine induced depletion of striatal SLI was not accompanied by alterations in dopamine or serotonin metabolism. Cysteamine is a useful pharmacologic tool for local somatostatin depletion.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003543:Cysteamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019856:Ethanolamine; D004983:Ethanolamines / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
D002395:Catecholamines; D004983:Ethanolamines; D013004:Somatostatin; D019856:Ethanolamine; D003543:Cysteamine