Effect of cholinomimetics on the release and uptake of L-[3H] glutamic acid in rat neostriatum.
The effects of cholinomimetics on the release and uptake of L-glutamic acid have been studied by means of local superfusion of rat neostriatum (in vivo) and using striatum slices (in vitro). Cholinomimetics regulate the release of L-glutamic acid through both muscarinic (m-) and nicotinic (n-) choline receptors according to the mechanism of negative feedback. Cholinomimetics regulate release through presynaptic receptors. The effect of n-cholinomimetics is mediated by neostriatum interneurons.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000502:physiology; D002799:Cholinergic Fibers / Q000502:physiology; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology; D005971:Glutamates / Q000378:metabolism* / Q000502:physiology; D018698:Glutamic Acid; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission
D005971:Glutamates; D018698:Glutamic Acid; D009538:Nicotine; D002217:Carbachol