SCH 23390 can enhance field stimulation-induced contractions of longitudinal smooth muscle from guinea-pig stomach.
Field stimulation-induced contractions of guinea-pig stomach longitudinal muscle strips were enhanced by metoclopramide (a D-2 receptor antagonist) and SCH 23390 (a D-1 receptor antagonist) but not by cis-flupenthixol (a D-1 and D-2 receptor antagonist) or sulpiride (a D-2 receptor antagonist). SCH 23390 is the first non-benzamide neuroleptic drug shown to enhance cholinergic mediated contraction responses of gastric smooth muscle, but the response does not appear to reflect a D-1 receptor antagonism.
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004347:Drug Interactions; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects*; D013270:Stomach / Q000187:drug effects
D001552:Benzazepines; D011954:Receptors, Dopamine