Some neurochemical consequences of repeated ethanol loading in rat brain.
Neurochemical consequences of repeated ethanol treatment on energy and ammonia metabolism were studied in different regions of rat brain. Energy production was decreased as indicated by lowered lactate dehydrogenase and succinate dehydrogenase activities with possible lacticacidimia. Transamination of alanine and aspartate increased while the deamination of glutamate decreased in all the regions of brain. The deamination of AMP was slightly elevated in cerebral cortex and brain stem while it was inhibited in cerebellum. Ammonia levels were persistently high, despite stepped up glutamine synthesis and ureogenesis. The synergistic action of ammonia during ethanol intoxication is envisaged.
D000659:AMP Deaminase / Q000378:metabolism; D000818:Animals; D001119:Arginase / Q000378:metabolism; D001124:Argininosuccinate Synthase / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004734:Energy Metabolism; D000431:Ethanol / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism; D000637:Transaminases / Q000378:metabolism
D005973:Glutamine; D000431:Ethanol; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase; D000637:Transaminases; D001119:Arginase; D000659:AMP Deaminase; D005974:Glutamate-Ammonia Ligase; D001124:Argininosuccinate Synthase