title: Effect of alloxan on the transport of dicarboxylate, tricarboxylate, pyruvate and glutamate in isolated mouse liver mitochondria.
abstract: The effect of alloxan on anion transport in isolated mouse liver mitochondria was studied with the swelling technique. Mitochondria pre-incubated with alloxan exhibited partial inhibition of the transport of malate, citrate, pyruvate and glutamate. 2n-butylmalonate caused complete inhibition of malate transport, and the translocation of citrate was completely blocked by 1,2,3-benzenetricarboxylate, while N-ethylmaleimide inhibited glutamate transport partially. The observation that alloxan inhibits different mitochondrial anion transport mechanisms emphasizes that the drug profoundly affects mitochondrial function.
mesh_terms: D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002951:Citrates / Q000378:metabolism*; D019343:Citric Acid; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D007700:Kinetics; D008293:Malates / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism*; D019289:Pyruvic Acid
chemical_list: D002951:Citrates; D005971:Glutamates; D008293:Malates; D011773:Pyruvates; D019343:Citric Acid; D018698:Glutamic Acid; D000496:Alloxan; C030298:malic acid; D019289:Pyruvic Acid