[Effect of adrenomimetic, adreno- and ganglionic-blocking agents during hyperbaric oxygenation].
Experiments on rats were made to study the action of hypotension and vasopressive agents. The effects obtained as a result of administering the drugs under common gas medium and hyperbaric oxygenation were compared. A considerable reduction of hypotensive action of alpha- and beta-adrenoblockers, ganglioblockers, beta-adrenomimetics and elimination of the effect of central alpha-adrenomimetics were discovered. The pressor effects of direct- and particularly of indirect-action alpha-adrenomimetics, as well as cardiotropic effects of beta-adrenoblockers were found to be potentiated. It is suggested that the action mode of oxygen is mediated via its direct- and primarily indirect-action adrenomimetic and beta-adrenoblocking effects. A classification of the periods of combined action of the drugs and hyperbaric oxygenation is suggested.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D004146:Dioxanes / Q000494:pharmacology; D004809:Ephedrine / Q000494:pharmacology; D005730:Ganglionic Blockers / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006931:Hyperbaric Oxygenation; D007545:Isoproterenol / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D013566:Sympathomimetics / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004146:Dioxanes; D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D011759:Pyrrolidines; D013566:Sympathomimetics; D010656:Phenylephrine; D011433:Propranolol; D004809:Ephedrine; D007545:Isoproterenol; D003000:Clonidine; C009143:proroxan; C021628:benzohexonium
Deĭstvie nekotorykh adrenomimeticheskikh, adreno- i ganglioblokiruiushchikh sredstv v usloviiakh giperbaricheskoĭ oksigenatsii.