title: Psychiatric abnormality and brain calcification over four generations.
abstract: An association between basal ganglia calcification and psychiatric abnormality, mainly schizophrenia, is described in three generations of a family; schizophrenia is also recorded in the previous generation. The mode of inheritance appears to be an X-linked dominant one. Unusual sensitivity to neuroleptics also occurred in four members of the family. No comparable family study is believed by the authors to have been reported previously.
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects; D001480:Basal Ganglia Diseases / Q000150:complications / Q000235:genetics*; D002114:Calcinosis / Q000150:complications / Q000235:genetics*; D002648:Child; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011618:Psychotic Disorders / Q000150:complications / Q000235:genetics*; D014960:X Chromosome
chemical_list: D014150:Antipsychotic Agents