title: Multimethodological approach in psychiatric predictor research.
abstract: The discussion of some methodological problems of predictor studies led to the following conclusions: 1. Different outcome criteria result in a different classification of patients as responders or non-responders. 2. Predictor variables and outcome criteria should be better defined. 3. The clinical relevance of a result can be estimated by calculating the proportion of explained variance. 4. Cross validation of results is necessary. 5. Changes during a test therapy of 10 days result in a relatively reliable prediction of outcome in acute schizophrenia and depression.
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000523:psychology; D011379:Prognosis; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents