title: Short- and long-term changes in adrenal tyrosine hydroxylase activity during insulin-induced hypoglycemia and cold stress.
abstract: Insulin-induced hypoglycemia increases the capacity for catecholamine biosynthesis in the rat adrenal medulla by two temporally distinct processes: a rapid increase in the affinity of tyrosine hydroxylase (TH) for cofactor and a more gradual increase in the maximal TH activity. Cold exposure leads to comparable long-term increases in adrenal TH activity, apparently without causing a prior activation of TH.
mesh_terms: D000313:Adrenal Medulla / Q000187:drug effects* / Q000201:enzymology; D000818:Animals; D003080:Cold Temperature; D004789:Enzyme Activation; D006706:Homeostasis; D007003:Hypoglycemia / Q000139:chemically induced* / Q000201:enzymology; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
chemical_list: D007328:Insulin; D014446:Tyrosine 3-Monooxygenase