Calcium binding to normal, regenerating and diabetic liver plasma membrane.
Calcium binding to liver plasma membrane isolated from diabetic and regenerating livers was significantly reduced (P less than 0.01) when compared to Ca binding to the normal membrane. Procaine at different concentrations inhibited significantly (P less than 0.01) calcium binding to the normal, diabetic and regenerating liver plasma membrane, with the most pronounced inhibition noticed in the normal. Colchicine at a concentration exceeding 5 X 10(-4)M showed a significant decrease (P less than 0.01) in calcium binding to the normal, diabetic and regenerating liver plasma membrane with the maximum inhibition noticed in the regenerating liver membrane.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003078:Colchicine / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D011343:Procaine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011343:Procaine; D003078:Colchicine; D002118:Calcium