Demethylation in vivo of a xanthine-related respiratory analeptic, ethimizol.
Demethylation of ethimizol in humans yielded 1-ethyl-4-carbamoyl-5-methyl-carbamoylimidazole. The formation, and the excretion in urine or saliva, of the other mono-N-demethylated ethimizol isomer, 1-ethyl-5-carbamoyl-4-methylcarbamoylimidazole has not been detected.
D000697:Central Nervous System Stimulants / Q000378:metabolism*; D003640:Dealkylation; D005042:Etimizol / Q000031:analogs & derivatives / Q000378:metabolism*; D006801:Humans; D007093:Imidazoles / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism
D000697:Central Nervous System Stimulants; D007093:Imidazoles; C040923:desmethyletimizol; D005042:Etimizol