title: Possible role of brain dopaminergic systems in the memory effects of central stimulants.
abstract: In experiments on male Wistar rats trained and tested for memory retention on an active avoidance task in a maze, it was found that haloperidol at doses of 0.2 and 2 mg/kg injected intraperitoneally one hour prior to or immediately after training impaired learning and/or memory. The central stimulants caffeine (20 mg/kg), strychinine (1 mg/kg) and amphetamine (1 mg/kg) injected intraperitoneally immediately after training improved long-term retention; the central stimulants administered at the same doses but in combination with haloperidol (2 mg/kg) after training did not manifest their retention-facilitating effect. It is assumed that dopaminergic mechanisms underlie learning and memory processes in active avoidance conditioning and that an optimum activity of these mechanisms is necessary for the memory-facilitating effect of the central stimulants to appear.
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000502:physiology*; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013331:Strychnine / Q000494:pharmacology
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine; D000661:Amphetamine; D013331:Strychnine; D006220:Haloperidol; D004298:Dopamine