Effects of acetylcholine and cholinolytics on the synaptic transmission in the ampullae of Lorenzini of the skate.
1. The effects of ACh, D-tubocuraine and atropine on the electrical activity of the ampullae of Lorenzini of the skate were studied. 2. ACh (10(-5)M) caused an increase in frequency of afferent discharges in all receptors under study. 3. When excitability was abolished by high Mg2+ solution (50 mM) perfusion with 50 mM Mg2+ plus ACh did not induce firing in the afferent fibres. 4. Cholinergic antagonists (D-tub and atr) did not block the synaptic transmission. 5. The results suggest that ACh is unlikely to be the synaptic transmitter in the ampullae of Lorenzini.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004553:Electric Conductivity; D004558:Electric Stimulation; D008274:Magnesium / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology
D001285:Atropine; D008274:Magnesium; D000109:Acetylcholine; D014403:Tubocurarine