Influence of biologically active substances isolated from Galleria mellonella on neurons of Lymnaea stagnalis in culture.
A procedure for isolating biologically active substances from Galleria mellonella using a culture of isolated giant neurons of mollusc Lymnaea stagnalis as a test-system is described. Fractions capable of activating neurites and inhibiting aggregation of neuronal cells within a range of concentrations from 1 to 30 micrograms/ml were isolated. The fractions obtained have in their chemical composition about 10.5% N, also contain P and S. They have a carbohydrate component.
D000818:Animals; D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology*; D002449:Cell Aggregation / Q000187:drug effects; D002478:Cells, Cultured; D007814:Larva / Q000032:analysis; D007915:Lepidoptera / Q000032:analysis*; D008195:Lymnaea / Q000187:drug effects / Q000378:metabolism*; D009036:Moths / Q000032:analysis*; D009474:Neurons / Q000166:cytology* / Q000187:drug effects
D001688:Biological Products