Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover.
D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000032:analysis; D000818:Animals; D001011:Aorta / Q000187:drug effects; D006152:Cyclic GMP / Q000378:metabolism* / Q000494:pharmacology; D004361:Drug Tolerance; D006162:Guanylate Cyclase / Q000032:analysis; D066298:In Vitro Techniques; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology*; D011494:Protein Kinases / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D011494:Protein Kinases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D006162:Guanylate Cyclase; D005996:Nitroglycerin; D006152:Cyclic GMP