Effect of penicillins on the level of inorganic pyrophosphatase in Escherichia coli K 12.
The relative rate of DNA synthesis increases over control level and the synthesis of inorganic pyrophosphatase is stimulated when cells of E. coli are cultured in the presence of penicillins which inhibit cell division and cause filamentation of the cells. In contrast to that in temperature sensitive cell division mutants filamentation at 42 degrees C does not change the DNA/cell mass ratio and the synthesis of inorganic pyrophosphatase is not stimulated. This suggests that the change in the synthesis of the enzyme is not correlated with the filamentation but is a consequence of the supernormal DNA/cell mass ratio that appears in the presence of penicillins.
D004926:Escherichia coli / Q000201:enzymology*; D043564:Inorganic Pyrophosphatase; D007700:Kinetics; D010406:Penicillins / Q000494:pharmacology*; D011755:Pyrophosphatases / Q000378:metabolism*; D013329:Structure-Activity Relationship
D010406:Penicillins; D011755:Pyrophosphatases; D043564:Inorganic Pyrophosphatase