Abnormalities of circulating lymphocyte subsets in haemophiliacs in an AIDS-free population.
Markers of the immune system were examined in 47 patients with haemophilia A and B who had been treated exclusively with blood products from a population apparently free from acquired immunodeficiency syndrome (AIDS). In haemophilia A the absolute number of T helper cells was depressed, resulting in a reduction in the helper/suppressor ratio in about half the patients. The serum IgG and IgA concentrations were raised and the serum IgG correlated with serum alanine aminotransferase. In haemophilia B, the helper/suppressor ratio was also depressed but this was attributable to a slight increase in the mean suppressor cell number and a slight decrease in the helper cells. These observations suggest that the abnormalities result from transfusion of foreign proteins and not from a specific infective agent and, further, that individuals may differ in susceptibility to the induced disturbances of immunity.
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005164:Factor IX / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use; D006467:Hemophilia A / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D002836:Hemophilia B / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007958:Leukocyte Count; D008111:Liver Function Tests; D008875:Middle Aged; D013601:T-Lymphocytes / Q000145:classification*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007136:Immunoglobulins; C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005164:Factor IX; D005340:Fibrinogen