Osteopetrosis in the Grüneberg (mi) mouse can be cured by cultured allogeneic bone marrow.
H2 compatible allogeneic bone marrow cultured for four weeks was effective in inducing bone resorption when injected intravenously into osteopetrotic mi mouse. The active cell line or its progenitors can therefore be established in culture and is probably derived from a haematopoietic stem cell (HSC).
D000818:Animals; D001862:Bone Resorption; D002478:Cells, Cultured; D005269:Femur / Q000473:pathology*; D005500:Follow-Up Studies; D006183:H-2 Antigens / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D007275:Injections, Intravenous; D051379:Mice; D010022:Osteopetrosis / Q000628:therapy*; D013997:Time Factors; D014184:Transplantation, Homologous
D006183:H-2 Antigens