Effects of growth hormone on lipogenesis and glucose oxidation in genetically GH-deficient mice.
Late inhibitory effects of growth hormone were observed when the hormone (0.1-1.0 microgram/ml) was incubated with adipose tissue from GH-deficient and normal mice. Early insulin-like effects of GH occurred only when glucose was used as precursor. Adult GH-deficient mice have a much higher basal acetyl-CoA carboxylase activity than normal mice. Administration of GH caused a marked reduction of enzyme activity in both groups.
D000103:Acetyl-CoA Carboxylase / Q000037:antagonists & inhibitors; D000818:Animals; D004392:Dwarfism / Q000378:metabolism*; D005227:Fatty Acids / Q000096:biosynthesis*; D005947:Glucose / Q000378:metabolism*; D013006:Growth Hormone / Q000172:deficiency / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010084:Oxidation-Reduction
D005227:Fatty Acids; D013006:Growth Hormone; D000103:Acetyl-CoA Carboxylase; D005947:Glucose