title: Hypnotic effects of a benzodiazepine derivative: a clinical observation.
abstract: A double-blind study was conducted on triazolam, using nitrazepam and placebo as control compounds; statistically significant differences were demonstrated in favor of triazolam compared with placebo and with nitrazepam in many aspects of efficacy, but there was no significant difference between triazolam and nitrazepam in the incidence of concomitant symptoms and side effects. The fact that a certain quantity of triazolam is equivalent in strength to ten times that quantity of nitrazepam suggests the high potency of the former. These data indicate that triazolam is a valuable sleep inducer, with highly-rated efficacy and safety.
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006760:Hospitalization; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D001523:Mental Disorders / Q000150:complications; D008875:Middle Aged; D009567:Nitrazepam / Q000494:pharmacology / Q000627:therapeutic use; D010919:Placebos; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000188:drug therapy; D014229:Triazolam / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D010919:Placebos; D014229:Triazolam; D009567:Nitrazepam