title: [Side-effects of beta-receptor blockaders on the skin].
abstract: Cutaneous side effects due to beta-adrenoreceptor-blocking agents are clinically polymorphous. Apparently they appear after several months of continuous therapy. Atypical psoriasiform, lichen planus-like, and eczematous "chronic" rashes are mainly observed. The histological picture usually corresponds to a lichenoid drug reaction. More rarely the so-called pseudo-lupus erythematodes-syndrome is found, which cannot be differentiated from the "idiopathic" disease. Noteworthy extracutaneous manifestations are fibrosing processes, which may be irreversible. Pathogenetically, a delayed hypersensitivity reaction, and an action on the epidermal chalone system (epinephrine-adenylcyclase-c-AMP-complex) may be assumed. Consequently, continuous observation of the skin and mucous membranes is necessary, and medication should be withdrawn if cutaneous side-effects appear.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D005076:Exanthema / Q000139:chemically induced; D006801:Humans; D008010:Lichen Planus / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced; D012871:Skin Diseases / Q000139:chemically induced*
chemical_list: D000319:Adrenergic beta-Antagonists
vernacular_title: Nebenwirkungen der Beta-Rezeptorenblocker an der Haut.