title: Nadolol binding to human serum proteins.
abstract: Nadolol protein binding was measured in serum from 95 healthy subjects. Binding was found to range between 4 and 27%, with a mean of 14 +/- 4% (s.d.). There was a small but significant correlation found between the degree of nadolol binding and the serum alpha-1-acid glycoprotein concentration. However it was concluded that changes in the serum protein binding of nadolol were unlikely to give rise to any untoward clinical effects.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000097:blood*; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009248:Nadolol; D009961:Orosomucoid / Q000378:metabolism; D011412:Propanolamines / Q000097:blood*; D011485:Protein Binding
chemical_list: D000319:Adrenergic beta-Antagonists; D001798:Blood Proteins; D009961:Orosomucoid; D011412:Propanolamines; D009248:Nadolol