Studies on the effect of paraquat on glycogen mobilization in liver of common carp (Cyprinus carpio L.).
1. A herbicide, paraquat (1,1'dimethyl-4,4'-bipyridilium-dichloride) was administered to carp in 0.5-10.0 ppm concentrations, respectively, and blood sugar level, glucose-6-phosphatase and glycogen phosphorylase activities of liver were determined. 2. Paraquat treatment caused an increase of blood sugar level and enhanced phosphorylase and glucose-6-phosphatase activities. 3. Paraquat can induce alterations in endoplasmic reticulum that might contribute to the changes in glucose-6-phosphatase activity, resulting in an increase of blood glucose level and/or all the effects can be attributed to a high level of circulating epinephrine produced by paraquat toxicosis.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002347:Carps / Q000378:metabolism*; D003530:Cyprinidae / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010269:Paraquat / Q000494:pharmacology*; D006005:Phosphorylases / Q000378:metabolism
D001786:Blood Glucose; D006003:Glycogen; D006005:Phosphorylases; D005952:Glucose-6-Phosphatase; D010269:Paraquat