Confirmation of F13A assignment and sequence information concerning F13A-HLA-GLO.
The polymorphism of the blood clotting factor F13A was examined in some of our Danish material of normal families. A total of four alleles were recognized, with allele frequencies as follows: F13A *1 = 0.817, F13A *2 = 0.177, F13A *4 = 0.003 and a new allele F13A *5 = 0.003. The distribution of unrelated individuals did not deviate significantly from the Hardy-Weinberg expectation. Linkage of F13A with HLA was confirmed (z = 5.18, theta = 0.17 in males and z = 0.14, theta = 0.37 in females). The sequence of the three systems F13A, HLA and GLO was found to be F13A-HLA-GLO as judged from two families each with a recombinant within the HLA system in males.
D005176:Factor XIII / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012737:Sex Factors; D011503:Transglutaminases
D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D005176:Factor XIII; D011503:Transglutaminases