The role of alpha-adrenoceptor blockade in the treatment of hypertension.
Early attempts to use alpha-adrenoceptor blockers in the treatment of hypertension were unsuccessful due to a high prevalence of side-effects. Now that the concept of two alpha-adrenoceptors, alpha 1 and alpha 2 has been investigated, specific alpha 1 postsynaptic adrenoceptor blocking drugs have become available to treat hypertension. Their efficacy, tolerance and acceptability are discussed, and indications for their usage suggested.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007217:Indoramin / Q000009:adverse effects / Q000627:therapeutic use; D011224:Prazosin / Q000009:adverse effects / Q000627:therapeutic use; D011942:Receptors, Adrenergic, alpha / Q000502:physiology
D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D007217:Indoramin; D011224:Prazosin