[Effect of talinolol on the activity of the mixed-function oxidases of rat liver].
Experiments with male rats were performed to compare the in vitro and in vivo effects of talinolol with those of propranolol, alprenolol, practolol, proadifen (SKF 525-A) and barbital. Three in vitro model reactions (amino-phenazone N-demethylation, p-nitroanisol O-demethylation and aniline hydroxylation) as well as the hexobarbital lateral-position time served as parameters. The results obtained show that talinolol, like the other beta-receptor blockers, can inhibit polyfunctional oxidases. There were no indications of an inductive action.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001462:Barbital / Q000494:pharmacology; D001711:Biotransformation; D008099:Liver / Q000201:enzymology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D011335:Proadifen / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C011550:talinolol; D001462:Barbital; D011335:Proadifen; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases
Untersuchungen über die Wirkung von Talinolol auf die Aktivität der mischfunktionellen Oxidasen der Rattenleber.