A comparison in rat and mouse heart of the ability of several local anesthetics to inhibit monoamine oxidase.
Several local anesthetics were examined and compared in rat and mouse heart for MAO inhibitory action. Procaine, chloroprocaine, procainamide and tetracaine were more potent in rat than mouse heart. Piperocaine, cyclomethycaine, hexylcaine and butacaine were somewhat more potent in mouse than rat heart. Propoxycaine and dibucaine were essentially equipotent in the two tissues. Since rat heart possesses primarily type A and mouse heart primarily type B MAO, these results suggest that some local anesthetics have a preferential action on one form of the enzyme while others have a preferential action on the other. Still another group has a non-preferential action.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D008996:Monoamine Oxidase Inhibitors; D009206:Myocardium / Q000201:enzymology*; D013045:Species Specificity
D000779:Anesthetics, Local; D008996:Monoamine Oxidase Inhibitors