[Therapy of duodenal ulcer with H2-blockers. 2 x 150 mg ranitidine versus 2 x 400 mg cimetidine].
60 out-patients with acute duodenal ulcers were treated in an open randomized trial with 2 x 150 mg ranitidine or 2 x 400 mg cimetidine, respectively. At endoscopy after 12 and 24 days there was evidence of complete healing in 63% and 93% in the ranitidine- and 57% and 83% in the cimetidine-treated group. Although the symptoms in both groups improved during treatment with H2-blockers, there was a more rapid relief in pain in the ranitidine-group (p less than 0.01). The more favorable results with ranitidine, 150 mg twice daily, warrant further clinical evaluation.
D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D011899:Ranitidine
D005663:Furans; D006146:Guanidines; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine
Therapie des Ulcus duodeni mit H2-Blockern. 2 x 150 mg Ranitidin versus 2 x 400 mg Cimetidin.