DNA damage induced by the antihistaminic drug methapyrilene hydrochloride.
Treatment of primary cultures of rat hepatocytes with the antihistaminic drug, methapyrilene hydrochloride, stimulated DNA-repair synthesis up to 7-fold and caused the formation of alkaline-labile lesions in hepatocellular DNA. These data clearly demonstrate that methapyrilene hydrochloride is a DNA damaging agent. In view of a recent report and our own findings we suggest that this antihistamine has the properties of a complete carcinogen.
D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects; D008297:Male; D008701:Methapyrilene / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D000631:Aminopyridines; D002273:Carcinogens; D006634:Histamine H1 Antagonists; D004247:DNA; D008701:Methapyrilene