Genetic control of progressive autonomic failure: evidence for an association with an HLA antigen.
In 16 patients with progressive autonomic failure, a rare disease of unknown cause, the frequency of the HLA antigen Aw32 was 13 times more common than in healthy controls, giving a relative risk of progressive autonomic failure with Aw32 of 28.7. Such genetic predisposition to the disease might cause a defect of catecholamine metabolism In the brain or possibly affect the immune response to a virus.
D001342:Autonomic Nervous System Diseases / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D015234:HLA-A Antigens; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; D006801:Humans; D007024:Hypotension, Orthostatic / Q000235:genetics / Q000276:immunology; D012306:Risk
D006680:HLA Antigens; D015234:HLA-A Antigens; C531148:HLA-A*32 antigen; D015789:HLA-A2 Antigen; D015235:HLA-B Antigens; C035015:HLA-B12 antigen