Effect of somatostatin on basal concentrations of gastrin and pancreatic polypeptide in the fetal sheep.
The effect of somatostatin infusion on basal plasma gastrin and pancreatic polypeptide (PP) has been examined in the chronically cannulated fetal sheep and in adult sheep. Somatostatin decreased basal gastrin and PP in the fetal sheep. Similar changes were seen in the adult sheep. A rebound of gastrin and PP above control levels occurred when the somatostatin infusion ceased in the adult, but this rebound was not seen in the fetus, probably from the absence of a fetal acid-gastrin feed back loop. The data is compatible with the hypothesis that in the fetus, the low plasma levels of gastrin and PP in mid-gestation are from the inhibition of their secretion by somatostatin.
D000818:Animals; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005755:Gastrins / Q000097:blood*; D010191:Pancreatic Polypeptide / Q000097:blood*; D011247:Pregnancy; D012756:Sheep / Q000196:embryology*; D013004:Somatostatin / Q000494:pharmacology*
D005755:Gastrins; D013004:Somatostatin; D010191:Pancreatic Polypeptide