title: Symptoms after primary immunisation with DTP and with DT vaccine.
abstract: Symptoms after routine primary immunisation of 6004 infants with diphtheria/tetanus/pertussis (DTP) vaccine and 4024 infants with diphtheria/tetanus (DT) vaccine have been compared. After each dose, crying, screaming, and feverishness were more frequent with adsorbed DTP than adsorbed DT, but the difference was small. Attacks of high-pitched screaming, episodes of pallor or cyanosis with limpness, convulsions, and local reactions occurred with similar frequency after both vaccines. There was a considerable increase in local reactions after the 3rd dose with both vaccines. Over 1000 doses of plain DTP (with no aluminium hydroxide adjuvant) were given during the study. Post-vaccination symptoms were more common after the plain than after the 2 adsorbed preparations.
mesh_terms: D003448:Crying; D003490:Cyanosis / Q000209:etiology; D004168:Diphtheria Toxoid / Q000009:adverse effects* / Q000276:immunology; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations / Q000009:adverse effects / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010167:Pallor / Q000209:etiology; D010567:Pertussis Vaccine / Q000009:adverse effects* / Q000276:immunology; D012640:Seizures / Q000209:etiology; D013398:Sudden Infant Death / Q000209:etiology; D013745:Tetanus Toxoid / Q000009:adverse effects* / Q000276:immunology; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid