Effect of neuroleptics on release on acetylcholine to the lateral cerebral ventricle in the rat.
Release of acetylcholine (ACh) to the lateral brain ventricle of non-anaesthetised rats was investigated 24 h after intraperitoneal administration of neuroleptics or simultaneous administration of clonidine or apomorphine given subcutaneously. The only significant observed effect was an increase of ACh release by clozapine.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D002552:Cerebral Ventricles / Q000378:metabolism*; D003000:Clonidine / Q000494:pharmacology; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D010830:Physostigmine; D003000:Clonidine; D001058:Apomorphine; D000109:Acetylcholine