Effect of acute aluminium overload on calcium and parathyroid-hormone metabolism.
Accidental exposure of 25 patients on continuous ambulatory peritoneal dialysis to a high aluminium level in the dialysate for a month provided an opportunity to investigate the interrelation between the metabolism of parathyroid hormone (PTH), calcium, and aluminium. After exposure to the high-aluminium dialysate, the mean serum aluminium had risen from 1.85 to 7.11 mumol/l and serum calcium from 2.27 to 2.44 mmol/l, and serum PTH had fallen from 744 to 580 ng/l. After a further 2 months, during which time the dialysate was aluminium-free, the mean serum aluminium and calcium fell to previous levels. There were no changes in calcium or vitamin-D therapy which could have influenced these results. The rise in serum calcium and fall in PTH during a period of aluminium toxicity strongly support the hypothesis that aluminium suppresses PTH through an elevation of serum calcium.
D000061:Accidents, Home; D000535:Aluminum / Q000506:poisoning*; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D004340:Drug Contamination; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012996:Solutions; D014018:Tissue Distribution
D010281:Parathyroid Hormone; D012996:Solutions; D000535:Aluminum; D002118:Calcium