Insulin release pattern after blockade of catecholamine synthesis with alpha-methyl tyrosine in vivo.
Insulin release pattern in vivo was studied using 30 control rats and 30 rats treated with alpha-methyl tyrosine to block catecholamine synthesis in vivo four days before the time of investigation. The drug treated animals exhibited significantly higher fasting insulin levels, and also the first phase insulin release after the B cell was challenged with a glucose load was significantly higher in these animals than occurred in the controls. This observation implies that the B cell is modulated by the sympathetic nervous system in its function and the insulin release would vary according to the emotional state of the individual.
D000818:Animals; D002395:Catecholamines / Q000096:biosynthesis*; D005215:Fasting; D005260:Female; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors*; D019805:alpha-Methyltyrosine
D002395:Catecholamines; D007328:Insulin; D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D014446:Tyrosine 3-Monooxygenase