Menstrual blood loss in dysmenorrhoea: effects of proquazone and indomethacin.
Abnormal production of uterine prostaglandins (PG) causes primary dysmenorrhoea and excessive menstrual blood loss (MBL). We measured here MBL in primary dysmenorrhoea and found it to be normal during treatment with opiate analgesics (33.5 +/- 21.6 ml; mean +/- SD. n = 13), placebo (33.4 +/- 18.6 ml; n = 8), proquazone (31.8 +/- 18.0 ml; n = 8) and indomethacin (26.4 +/- 18.7 ml; n = 8). Proquazone and indomethacin relieved pain and other dysmenorrhoeic symptoms similarly in 33 women.
D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors; D004412:Dysmenorrhea / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008598:Menstruation / Q000187:drug effects; D011799:Quinazolines / Q000627:therapeutic use*
D000700:Analgesics; D000701:Analgesics, Opioid; D016861:Cyclooxygenase Inhibitors; D011799:Quinazolines; C011385:proquazone; D007213:Indomethacin