Bile enzyme activities following choledochotomy and the effect of steroid treatment.
The alkaline phosphatase (AP) and gamma-glutamyl-transpeptidase (GGT) activities and the effect of steroid treatment were studied in human bile and serum following choledochotomy. Activity of the two enzymes in the bile changed in parallel. Following the operation the enzyme activities initially decreased, but after 3 days they showed a progressive increase and reached their maximum on day 6. It appears that the bile is a major route for the elimination of both enzymes from the damaged liver. 60 mg Prednisolone on the day of operation and 2 days after surgical intervention prevented the initial decline in enzyme activity and significantly increased the excretion of enzymes. The possible pathogenesis of enzymatic changes after choledochotomy is discussed.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D001646:Bile / Q000201:enzymology*; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000188:drug therapy / Q000201:enzymology / Q000601:surgery; D003135:Common Bile Duct / Q000601:surgery*; D005260:Female; D042882:Gallstones / Q000188:drug therapy / Q000201:enzymology / Q000601:surgery; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D011239:Prednisolone; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase