Enhanced effect of haloperidol and apomorphine after hypophysectomy: pharmacokinetic considerations.
The behavioural effects of both apomorphine (stereotypies) and haloperidol (catalepsy and reversal of stereotypies) were significantly enhanced in hypophysectomized rats compared with sham-operated rats. Both the efficacy and duration of action were increased Hypophysectomized animals had significantly greater brain haloperidol concentrations than did sham-operated animals. The data suggest that changes in brain drug concentrations following hypophysectomy at least partially explain the behavioural alterations seen in this test situation.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002375:Catalepsy / Q000139:chemically induced; D006220:Haloperidol / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007016:Hypophysectomy; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D006220:Haloperidol; D001058:Apomorphine