REM-latency in neuroleptic drug withdrawal. A case report.
This case report is one of the few observations in man showing REM-latency reduction as one of the neurophysiological consequences of abrupt neuroleptic suspension. One should take care not to attribute diagnostic significance to EEG or sleep-features which may be drug-dependent. The underlying neurochemical mechanisms are discussed, transient cholinergic overactivity is emphasized in neuroleptic withdrawal.
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004569:Electroencephalography; D006801:Humans; D008297:Male; D011950:Receptors, Cholinergic / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D014150:Antipsychotic Agents; D011950:Receptors, Cholinergic