Forskolin stimulates renin release from the isolated perfused rat kidney.
Forskolin, a novel receptor-independent adenylate cyclase activator, stimulated renin release from the isolated perfused rat kidney twofold at 10(-7) M and threefold at 10(-6) M. This stimulation was blocked by angiotensin II but not by the beta-adrenoceptor antagonist atenolol. These findings strengthen the concept that an intracellular increase of 3',5'-cyclic AMP by adenylate cyclase activation can induce stimulation of renin release.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D005576:Colforsin; D000242:Cyclic AMP / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*
D000318:Adrenergic beta-Agonists; D004224:Diterpenes; D010726:Phosphodiesterase Inhibitors; D000804:Angiotensin II; D005576:Colforsin; D003994:Bucladesine; D000242:Cyclic AMP; D012083:Renin; D000262:Adenylyl Cyclases