Evidence that the pathophysiology of depression and the mechanism of action of antidepressant drugs both involve alterations in circadian rhythms.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D006224:Cricetinae; D003866:Depressive Disorder / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D012895:Sleep, REM / Q000502:physiology
D000928:Antidepressive Agents; D018377:Neurotransmitter Agents; D006854:Hydrocortisone