Eye drops of RU 486-6, a peripheral steroid blocker, lower intraocular pressure in rabbits.
A peripheral corticosteroid blocker RU 486-6, instilled as a 1% suspension at random into one eye of 12 rabbits, produced a consistent fall in intraocular pressure as measured by a hand-held applanation tonometer, when compared with the fellow control eye. This or a similar drug may be applicable for treatment of human open-angle glaucoma, or ocular hypertension, by eliminating that part of ocular tension attributable to the effect on aqueous outflow of the normal and fluctuating level of tissue corticosteroids.
D000818:Animals; D002908:Chronic Disease; D004963:Estrenes / Q000494:pharmacology* / Q000627:therapeutic use; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D015735:Mifepristone; D009798:Ocular Hypertension / Q000188:drug therapy; D009883:Ophthalmic Solutions; D011817:Rabbits
D004963:Estrenes; D009883:Ophthalmic Solutions; D015735:Mifepristone