[Effect of N- and M- cholinoblockaders on experimental epileptogenesis].
It has been shown in chronic experiments on rabbits with epileptogenic foci provoked by microinjections of penicillin into the dorsal hippocamp that the N-cholinoblockers gangleron (3 mg/k, intravenously) and etherophen (5-10mg/kg, intravenously) possess marked anticonvulsant activity. Diphenin (50 mg/kg, intraperitoneally) was less potent. The M-cholinoblocker methamizil (1 mg/kg, intravenously), on the contrary, potentiated the epileptiform seizures. Emphasis is laid on the necessity of the goal-oriented synthesis and search for agents that would exhibit a "purely" central N-cholinoblocking action with a purpose of applying such agents as antiepileptic drugs. It is not recommended using the M-cholinoblockers for such purposes.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001535:Benactyzine / Q000031:analogs & derivatives / Q000627:therapeutic use; D001565:Benzoates / Q000627:therapeutic use; D004158:Diphenylacetic Acids / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D010276:Parasympatholytics / Q000627:therapeutic use*; D010672:Phenytoin / Q000627:therapeutic use; D011817:Rabbits; D012640:Seizures / Q000188:drug therapy*; D013565:Sympatholytics / Q000627:therapeutic use*
D000927:Anticonvulsants; D001565:Benzoates; D004158:Diphenylacetic Acids; D010276:Parasympatholytics; D013565:Sympatholytics; C002675:ethyldiphacil; C008380:metamizil; D001535:Benactyzine; D010672:Phenytoin; C007824:ganglerone
Vliianie N- i M-kholinoblokatorov na éksperimental'nyĭ épileptogenez.