Effect of anti-inflammatory drugs on partitioning characteristics of propranolol and oxprenolol.
The influence of a range of nine anti-inflammatory drugs on the octan-1-ol aqueous phosphate buffer pH 7.4 apparent partition coefficients of propranolol and oxprenolol has been examined. All produced a change in the apparent partition coefficient which can be explained in terms of partitioning of hydrophobic ion-pairs formed between the ionic anti-inflammatory compound and the protonated cationic drug.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D010096:Oxprenolol; D011433:Propranolol; D012995:Solubility
D000893:Anti-Inflammatory Agents; D010096:Oxprenolol; D011433:Propranolol