Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones.
Glutamate and the glutamate analogue AMPA ((RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid) caused depolarizations of cultured rat spinal and brainstem neurones which were reversibly antagonized by the glutamate antagonist glutamic acid diethylester (GDEE) but not by 2-amino-5-phosphonovalerate (APV), an N-methyl-D-aspartate (NMDA) antagonist. In contrast, depolarizations by NMDA were blocked by APV but not by GDEE. These results suggest that the depolarization by AMPA is caused by the activation of glutamate/quisqualate-preferring receptors.
D015763:2-Amino-5-phosphonovalerate; D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D001933:Brain Stem / Q000187:drug effects*; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D005971:Glutamates / Q000008:administration & dosage; D007051:Ibotenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D016202:N-Methylaspartate; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D013116:Spinal Cord / Q000187:drug effects*; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D005971:Glutamates; D010080:Oxazoles; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; C011829:glutamic acid diethyl ester; D007051:Ibotenic Acid; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D014633:Valine