Effect of secoverine and atropine on intestinal secretion and motor activity in the rat small intestine in-vivo.
The actions of secoverine and atropine on bethanechol-induced intestinal secretion, hypermotility and transintestinal potential difference were investigated in the rat jejunum in-vivo. Both secoverine (10(-7) mol kg-1) and atropine (1.2 X 10(-9) mol kg-1) inhibited motility at doses that did not affect secretion or transintestinal potential difference. However, secoverine was a less potent antagonist of all the bethanechol-induced changes than atropine. Increases in transintestinal potential difference were more closely related to production of fluid secretion than to increases in motility.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001626:Bethanechol Compounds / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007419:Intestinal Secretions / Q000187:drug effects*; D007583:Jejunum / Q000502:physiology; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D010627:Phenethylamines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects
D001626:Bethanechol Compounds; D010276:Parasympatholytics; D010627:Phenethylamines; D011976:Receptors, Muscarinic; C028187:secoverine; D001285:Atropine