[Effect of C-terminal tetrapeptide cholecystokinin (CCK-4) on the function of the islands of Langerhans and the adenohypophysis].
A study was made of the action of C-terminal tetrapeptide cholecystokinin (CCK-4) on the secretory function of A-, B- and D-cells of the islets of Langerhans and on the lactotropic function of the hypophysis. Intravenous injection into rats of CCK-4 in doses of 5 and 50 micrograms/kg bw resulted within 2 min in increased blood immunoreactive insulin. Tetrapeptide also exerted a stimulant dose-dependent action on the function of insulin-, glucagon- and somatostatin-secreting pancreatic cells of the pancreatic islets in culture at concentrations ranging within 10(-9)-10(-6)M. When given in the same doses CCK-4 did not affect basal or dopamine-inhibited prolactin secretion by cultured adenohypophyseal cells. It is concluded that CCK-4 stimulates insulin, glucagon and somatostatin secretion by direct contact with target cells.
D000818:Animals; D005755:Gastrins / Q000494:pharmacology*; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism; D013758:Tetragastrin / Q000494:pharmacology*
D005755:Gastrins; D007328:Insulin; D013758:Tetragastrin; D013004:Somatostatin; D011388:Prolactin; D005934:Glucagon
Vliianie C-kontsevogo tetrapeptida kholetsistokinina (CCK-4) na funktsiiu ostrovkov Langergansa i adenogipofiza.