The effect of temperature on the alpha-adrenoceptor antagonist potency of indoramin and labetalol in the rat perfused mesenteric vascular bed.
The effect of reduction in temperature of perfusion from 37 to 27 degrees C and 20 degrees C on the ability of the adrenoceptor antagonists indoramin and labetalol to block pressor responses to noradrenaline in the perfused mesenteric vascular bed of the rat was examined. The results suggest that in rat mesenteric bed, antagonist potency of both agents is increased at low temperatures.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D004983:Ethanolamines / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007217:Indoramin / Q000494:pharmacology*; D007741:Labetalol / Q000494:pharmacology*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013152:Splanchnic Circulation / Q000187:drug effects*; D013696:Temperature
D000317:Adrenergic alpha-Antagonists; D004983:Ethanolamines; D007211:Indoles; D007217:Indoramin; D007741:Labetalol