[Hormonal induction of tyrosine aminotransferase in animal liver during chronic poisoning with ethanol and carbon tetrachloride].
Repeated administration of ethanol into animals within 14 and 21 days decreased or completely abolished the inducing effect of ethanol on the tyrosine aminotransferase activity (TAT) in liver tissue. At the same time, the inducing effect of hydrocortisone was maintained although at the lower level as compared with the intact animals. Chronic poisoning of the animals with CCl4 within 4 weeks inhibited the inducing effect. As compared with controls the inducing effect of hydrocortisone was distinctly lower in the animals poisoned with CCl4.
D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D004790:Enzyme Induction; D006638:Histidine Ammonia-Lyase / Q000096:biosynthesis; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008808:Mice, Inbred CBA; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D014444:Tyrosine Transaminase; D006638:Histidine Ammonia-Lyase; D006854:Hydrocortisone
Gormonal'naia induktsiia tirozinaminotransferazy pecheni zhivotnykh pri khronicheskoĭ intoksikatsii étanolom i chetyrekhkhloristym uglerodom.