Immunohistochemical demonstration of peptide hormones in cervical adenocarcinomas with argyrophil cells.
Thirty patients with cervical adenocarcinoma were analyzed clinicopathologically with special reference to argyrophil cells. In contrast to argyrophil small cell carcinoma of the cervix, four adenocarcinomas with argyrophil cells were not more aggressive than the remaining 26 usual ones. One or two peptide hormones were demonstrated in three out of four tumors with argyrophil cells which were examined by immunohistochemistry. Somatostatin- and gastrin-containing cells were found in one tumor, but were located differently from each other. Either gastrin- or adrenocorticotropic hormone (ACTH)-containing cells were detected in two other tumors. They all corresponded to argyrophil cells, but were less numerous.
D000230:Adenocarcinoma / Q000032:analysis* / Q000473:pathology; D000328:Adult; D004759:Enterochromaffin Cells / Q000032:analysis; D005260:Female; D005755:Gastrins / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D010455:Peptides / Q000032:analysis*; D013004:Somatostatin / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000032:analysis* / Q000473:pathology
D005755:Gastrins; D010455:Peptides; D013004:Somatostatin