Demonstration of tissue 90 kD glycoprotein as antigen in circulating IgG immune complexes in dermatitis herpetiformis and coeliac disease.
Mannose-rich 90 kD glycoprotein, a constituent of skin and small-bowel mucosa, was identified as antigen in circulating IgG-type immune complexes in dermatitis herpetiformis and coeliac disease by means of an enzyme-linked immunosorbent assay. High levels of 90 kD glycoprotein-IgG complexes were found in 7 out of 12 patients with dermatitis herpetiformis and in 10 out of 20 patients with coeliac disease but in only 2 out of 20 patients with systemic lupus erythematosus. The highest levels of 90 kD antigen-IgG complexes were found in patients with dermatitis herpetiformis. The amount of these complexes did not correlate with the degree of jejunal villous atrophy. The 90 kD glycoprotein-containing immune complexes with targets in skin and gut may be involved in the pathogenesis of dermatitis herpetiformis and coeliac disease.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis*; D000941:Antigens / Q000032:analysis; D002446:Celiac Disease / Q000276:immunology*; D003874:Dermatitis Herpetiformis / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis*; D007413:Intestinal Mucosa / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008875:Middle Aged; D008970:Molecular Weight; D012217:Rheumatoid Factor / Q000276:immunology; D012867:Skin / Q000276:immunology
D000936:Antigen-Antibody Complex; D000941:Antigens; D006023:Glycoproteins; D007074:Immunoglobulin G; D012217:Rheumatoid Factor