Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum.
An intracerebroventricular injection of d-coclaurine (50 micrograms), a benzyltetrahydroisoquinoline alkaloid extracted from Magnolia salicifolia, produced a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. Another alkaloid d-reticuline (200 micrograms) increased only homovanillic acid level. An intracerebroventricular pretreatment with d-coclaurine (50 micrograms) did not antagonize suppressive effect of apomorphine on l-dopa formation produced by gamma-butyrolactone (750 mg/kg i.p.) plus aromatic amino acid decarboxylase inhibitor, NSD-1015 (100 mg/kg i.p.). These results suggest that d-coclaurine blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D015107:4-Butyrolactone / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D044182:Benzylisoquinolines; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism*; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000494:pharmacology*; D007980:Levodopa / Q000096:biosynthesis; D008297:Male; D051379:Mice; D010648:Phenylacetates / Q000378:metabolism*
D000470:Alkaloids; D014150:Antipsychotic Agents; D044182:Benzylisoquinolines; D007546:Isoquinolines; D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; D007980:Levodopa; C004690:coclaurine; D015107:4-Butyrolactone; C003298:reticuline; D006719:Homovanillic Acid