Immune response in neonates to hepatitis B vaccine.
Three injections of alum hepatitis B vaccine (HB vaccine) were given to 26 Senegalese infants, the first when they were less than 1 month old, and the second and third after 1-month intervals. 94.7% of the neonates whose serum was negative for hepatitis B surface antigen and antibodies against the surface antigen (anti-HBs) showed a specific anti-HBs response. Anti-HBs titres in the neonates were similar to those previously obtained in Senegalese children aged aged 1-24 months. HB vaccine was without sid-effects and was immunogenic in the neonates, irrespective of the hepatitis-B-marker status of the mothers or the children.
D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000517:prevention & control*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012675:Senegal; D014765:Viral Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D014765:Viral Vaccines