Expression of Thy1, TL and LYT antigens on spontaneous leukemias of BALB/MO strain of mice.
The expression of Thy1, TL and Tyt antigens on spontaneous BALB/Mo leukemias has been studied. The results obtained thus far indicate that a majority of leukemias express TL antigen and differentiated Lyt phenotype. This observation and other findings demonstrating the existence of TL+ thymocytes with different Lyt phenotypes in normal thymus of young mice lends support for the hypothesis that TL+Lyt2+ phenotype defines this stage in the T cell differentiation pathway, which is particularly sensitive to leukemic transformation.
D000818:Animals; D000941:Antigens; D000950:Antigens, Ly; D000954:Antigens, Surface; D007938:Leukemia / Q000276:immunology*; D008565:Membrane Proteins; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*; D018800:Thy-1 Antigens
D000941:Antigens; D000950:Antigens, Ly; D000954:Antigens, Surface; D008565:Membrane Proteins; D018800:Thy-1 Antigens