Effect of formulation on the bioavailability of retinol, D-alpha-tocopherol and riboflavine.
Formulation factors influencing vitamin bioavailability have been investigated, with vitamins A, E and B2, formulated in a new liquid vehicle (Aqua-Biosorb) and encapsulated into soft gelatin capsules, being compared with commercial formulations. There was an enhanced vitamin bioavailability from the new vehicle which appeared to be related to the surfactant system employed and the absence of vegetable oil in the formulation.
D000328:Adult; D001682:Biological Availability; D004304:Dosage Forms; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D012256:Riboflavin / Q000378:metabolism*; D012995:Solubility; D013501:Surface-Active Agents / Q000494:pharmacology; D014801:Vitamin A / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism*; D014815:Vitamins / Q000008:administration & dosage
D004304:Dosage Forms; D013501:Surface-Active Agents; D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D012256:Riboflavin