Effects of glucagon in vivo on the N-acetylglutamate, glutamate and glutamine contents of rat liver.
Glucagon injected into rats caused an increase in liver N-acetylglutamate content, and coincidentally the glutamate content decreased. The liver glutamine content decreased only after 10 min, consistent with an activation of glutaminase after a lag. These observations indicate that the increased N-acetylglutamate content was not due to an increase in glutamate content caused by an activation of glutaminase (EC 3.5.1.2).
D000818:Animals; D005934:Glucagon / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D005973:Glutamine / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D005973:Glutamine; D018698:Glutamic Acid; D005934:Glucagon; C016195:N-acetylglutamic acid