A study of inhibition of cholera toxin-induced intestinal hypersecretion by neuroleptics.
Various types of neuroleptics and other agents were examined for inhibitory effect in cholera toxin-induced hypersecretion in ligated loops of mice jejunum. Several agents belonging to the phenothiazine group or thioxanthene group were inhibitory. Only three other neuroleptics, loxapin, haloperidol and penfluridol, inhibited the hypersecretion. Among the miscellaneous agents the calcium antagonist nifedipine was inhibitory. The potencies of the neuroleptics did not correlate with the dopamine antagonistic potencies. The results indicate that the site of antisecretory action of the drugs is to be found outside the central nervous system.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002772:Cholera Toxin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D014150:Antipsychotic Agents; D011954:Receptors, Dopamine; D008774:Methylphenidate; D002772:Cholera Toxin