title: Clinical and biological correlates of sleep deprivation in depression.
abstract: Sleep deprivation is reported to have therapeutic effectiveness in depressive illness. Furthermore, the response to sleep deprivation has important research implications. Recent conceptual advances, resulting in increased understanding of the role of abnormal biological rhythms and neurotransmitter function of the pathophysiology of affective disorder, highlight the future role of sleep deprivation in the research and treatment of these disorders.
mesh_terms: D001714:Bipolar Disorder / Q000503:physiopathology / Q000628:therapy; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000503:physiopathology / Q000628:therapy*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008550:Melatonin / Q000378:metabolism; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis; D018377:Neurotransmitter Agents / Q000502:physiology; D011388:Prolactin / Q000378:metabolism; D012892:Sleep Deprivation / Q000502:physiology; D012894:Sleep Stages / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D008734:Methoxyhydroxyphenylglycol; D011388:Prolactin; D008550:Melatonin; D006854:Hydrocortisone; D006719:Homovanillic Acid