Beta-blocker therapy evaluated by radionuclide angiography: a study in chronic stable angina.
In order to evaluate the negative inotropic effects of sotalol, metoprolol, and propranolol in patients with chronic stable angina pectoris, left ventricular ejection fraction (LVEF) was measured with radionuclide angiography and echocardiography. Fifteen patients entered the study, which was designed as a randomized crossover trial. The patients served as their own control at all times. Surprisingly, LVEF increased when measured by echocardiography in all three treatment periods, and decreased in the propranolol period when measured by radionuclide methods. The changes were not significant. There was no negative inotropic effect registered during any of the three drug treatments.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002306:Cardiac Volume / Q000187:drug effects; D002908:Chronic Disease; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000627:therapeutic use; D011877:Radionuclide Imaging; D013015:Sotalol / Q000627:therapeutic use; D013318:Stroke Volume / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D013015:Sotalol; D008790:Metoprolol