title: The effect of decortication on the excitatory amino acid sensitivity of striatal neurones.
abstract: Rat striatal neurones which are deprived of their cortical innervation become more sensitive to the excitatory actions of L-glutamate relative to kainate and probably to other amino acids. The density of sodium-independent binding sites for glutamate and kainate is unaltered. The enhanced glutamate sensitivity may be a 'denervation supersensitivity' since the corticostriate pathway is believed to be glutamate-mediated. It is argued that the cytotoxic effects of kainate are unlikely to involve receptors on the affected cells themselves.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D002540:Cerebral Cortex / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D007608:Kainic Acid / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats
chemical_list: D000596:Amino Acids; D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D007608:Kainic Acid