Effects of bradykinin and various synthetic analogs on rat polymorphonuclear chemotaxis.
Rat polymorphonuclear chemotaxis was inhibited by bradykinin (BK). Among various synthetic analogs of BK it was demonstrated that some compounds exerted the same effect while others have none. It is suggested that we might distinguish two types of kinin receptors and that rat PMN possesses membrane receptors of B2 type.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D051381:Rats; D018002:Receptors, Bradykinin; D011956:Receptors, Cell Surface / Q000187:drug effects; D013329:Structure-Activity Relationship
D018002:Receptors, Bradykinin; D011956:Receptors, Cell Surface; D001920:Bradykinin