[Effects of several beta-blockers and penfluzide, a thiazide diuretic, on the blood pressure, urinary water output and excretion of Na and K in DOCA-saline-induced hypertension in rats].
Effects of beta-blockers on the blood pressure (BP), urinary output (V) and excretion of Na% (UNaV) and K+ (UKV) were studied in DOCA-saline hypertensive rats in comparison with those of a thiazide diuretic drug, penfluzide. Pindolol produced a hypotension at all infusion rates of Ringer's solution used and a decrease in V with a retention of Na+ and K+ at a low infusion rate. There was a parallel shift of Guyton's renal function curve back to the lower pressure ranges. Similar effects were observed with labetalol. Propranolol induced an increase in UKV at all infusion rates and had a diuretic action at a high infusion rate without producing a significant fall of BP. UKV tended to be increased after atenolol, with essentially no change in other parameters. A new beta-blocker with alpha-blocking action, K-351, produced a hypotension at intermediate and high infusion rates and an increase in UNaV (low infusion rate) and UKV (low and high rates). UKV tended to be increased with another new beta-blocker, N-696, with a fall of BP at high infusion rate. Penfluzide produced a significant decrease in BP at intermediate and high infusion rates and an increase in UKV at all infusion rates.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001581:Benzothiadiazines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D003900:Desoxycorticosterone; C008781:penfluzide; D012964:Sodium; D011188:Potassium