Uptake of D-[3H]aspartic acid by hippocampal slices: the influence of low and high frequency activation of nerve endings.
Schaffer collaterals (Sch. coll.) projection and perforant path (PP) fibers in the hippocampal slices were stimulated in the presence of 0.8 microM D-[3H]aspartic acid--a marker of glutamergic nerve terminals. The activation of these fibers evoked a frequency and sodium-dependent increase of D-[3H]aspartate uptake. The increase of D-aspartate uptake during Schaffer collaterals stimulation was much higher than during perforant path stimulation. The stimulation of Sch. coll. nerve endings, which was preceded by a high frequency stimulation of these fibers (potentiation), evoked a decrease of D-aspartate uptake as compared to stimulated controls.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D046508:Culture Techniques; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006624:Hippocampus / Q000502:physiology*; D008564:Membrane Potentials; D009411:Nerve Endings / Q000502:physiology*; D051381:Rats; D009435:Synaptic Transmission
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid