Chlorpromazine and related antipsychotic tricyclic compounds competitively inhibit the interaction between tumor-promoting phorbol esters and their specific receptors.
Various antipsychotic and antidepressant drugs have been tested for their effects on the binding of [3H] phorbol-dibutyrate (PDBu) to its specific receptor. Chlorpromazine and related antipsychotic tricyclic compounds competitively inhibit the interaction between tumor-promoting phorbol esters and their specific receptors. The relative potency of drugs in competing for [3H]PDBU to receptors is fluphenzine greater than flupenthioxal greater than 2-chloroimipramine greater than chlorpromazine greater than imipramine. The significance of these findings is discussed with special reference to the potential tumor-promoting activity of these drugs.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D002458:Cell Fractionation; D002746:Chlorpromazine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D051379:Mice; D010703:Phorbol Esters / Q000378:metabolism*; D010704:Phorbols / Q000378:metabolism*; D011493:Protein Kinase C; D011955:Receptors, Drug / Q000378:metabolism*
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D010703:Phorbol Esters; D010704:Phorbols; D011955:Receptors, Drug; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D011493:Protein Kinase C; D002746:Chlorpromazine