title: Ultrastructural study of transganglionic degeneration following dental lesions.
abstract: Transganglionic degeneration in the trigeminal main sensory nucleus (MSN) and pars interpolaris (PI) was studied in cats following dental lesions. At early survival times, three types of terminal alteration were seen in both MSN and PI: (1) flocculent degeneration, (2) neurofilamentous hyperplasia and, (3) glycogen accumulation. With longer survival times, the magnitude of these terminal alterations increases. Electron dense degeneration was only seen in the ventral half of PI. Phagocytosis of the altered terminals was also observed. The study suggests a plausible explanation for the variations observed in the CNS projection of primary afferents with degeneration and with HRP transport studies.
mesh_terms: D000818:Animals; D002415:Cats; D003599:Cytoskeleton / Q000648:ultrastructure; D006003:Glycogen / Q000378:metabolism; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000648:ultrastructure; D010587:Phagocytosis; D011670:Pulpectomy; D014070:Tooth / Q000294:innervation*; D014081:Tooth Extraction; D018677:Tooth Injuries; D014278:Trigeminal Nuclei / Q000648:ultrastructure*
chemical_list: D006003:Glycogen