Binding of antibodies against human prealbumin to intestinal and bronchial carcinoids and to pancreatic endocrine tumours.
Antibodies against human prealbumin (HPA) give a strong immunoperoxidase staining of the A (glucagon) pancreatic cells and of glucagon-, insulin- and gastrin-producing pancreatic tumours. The majority of intestinal and bronchial carcinoids are also reactive. The staining may be related to presence in the C-terminal sequence of HPA of determinants in common with polypeptide (pro-) hormones.
D007516:Adenoma, Islet Cell / Q000032:analysis*; D001666:Binding Sites, Antibody / Q000032:analysis*; D001984:Bronchial Neoplasms / Q000032:analysis*; D002276:Carcinoid Tumor / Q000032:analysis*; D002277:Carcinoma / Q000032:analysis; D005935:Glucagonoma / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007340:Insulinoma / Q000032:analysis; D007414:Intestinal Neoplasms / Q000032:analysis*; D010190:Pancreatic Neoplasms / Q000032:analysis*; D011228:Prealbumin / Q000276:immunology*; D015043:Zollinger-Ellison Syndrome / Q000032:analysis
D011228:Prealbumin