title: Randomised double-blind cross-over trial of potassium on blood-pressure in normal subjects.
abstract: A randomised double-blind cross-over study of increased oral potassium 64 mmol a day versus placebo was conducted in 20 young healthy males on normal sodium unrestricted diet. A significantly greater proportion had lower systolic and diastolic blood-pressures on potassium than on placebo. The mean diastolic pressure was significantly lowered, by 2.4 mm Hg, during potassium supplementation. Change in diastolic pressure correlated negatively with change in 24-hour urinary potassium and positively which change in 24-hour urinary sodium/potassium ratio in individual subjects.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003971:Diastole / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D011188:Potassium / Q000008:administration & dosage / Q000494:pharmacology* / Q000652:urine; D011897:Random Allocation; D012964:Sodium / Q000652:urine
chemical_list: D012964:Sodium; D011188:Potassium