Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy.
The frequency of the cases which showed the toxic levels and the relationship between the serum levels and mental symptoms were discussed on the basis of determination of the serum antiepileptic drugs. This was aimed at recognizing the effects of drug therapy in the appearance of some psychiatric symptoms in patients with epilepsy. The serum levels of folate and vitamin B12 were measured simultaneously to examine the relationship with some mental change. The direct cause-and-effect relationship could not be demonstrated between the serum levels and the mental symptoms.
D000927:Anticonvulsants / Q000009:adverse effects*; D001463:Barbiturates / Q000009:adverse effects; D002220:Carbamazepine / Q000009:adverse effects; D004827:Epilepsy / Q000188:drug therapy*; D005492:Folic Acid / Q000097:blood; D006801:Humans; D007700:Kinetics; D001523:Mental Disorders / Q000139:chemically induced*; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D011324:Primidone / Q000009:adverse effects; D014635:Valproic Acid / Q000009:adverse effects; D014805:Vitamin B 12 / Q000097:blood
D000927:Anticonvulsants; D001463:Barbiturates; D011324:Primidone; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D005492:Folic Acid; D014805:Vitamin B 12; D010634:Phenobarbital