[Effect of the antihistaminic preparation fencarol on cardio- and hemodynamics and the energy processes in the myocardium in an infarct-like immune lesion of the heart].
Experiments were made on anesthesized dogs with closed chest to examine the effect of the Soviet antihistaminic drug phencarol on the cardio- and hemodynamics energy metabolism and microcirculatory bed of the myocardium under focal immune injury to the heart. Preliminary administration of phencarol reduced the shifts in the cardio- and hemodynamics and energy metabolism in the myocardium, characteristic for immune injury. The affected area manifested a less marked rop of the systemic arterial pressure, myocardial contractility, the content of adenyl nucleotides, glycogen and phosphorylase activity. There was a considerable decrease in size of the affected area of the left ventricular myocardium.
D000818:Animals; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D007106:Immune Sera / Q000008:administration & dosage; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000276:immunology / Q000378:metabolism*
D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D007106:Immune Sera; C014742:quifenadine
Vliianie protivogistaminnogo preparata fankarola na kardio- i gemodinamiku i énergeticheskie protsessy v miokarde pri infarktopodobnom immunnom povrezhdenii serdtsa.