title: Treatment of Gilles de la Tourette's syndrome with clonidine and neuroleptics.
abstract: In an open clinical trial of clonidine hydrochloride and neuroleptics in patients with Gilles de la Tourette's syndrome, neuroleptics resulted in greater improvement across the range of symptoms in a larger proportion of patients than did clonidine. A small subgroup of patients may have benefited from treatment with clonidine. Carefully controlled, randomized, and double-blind studies are necessary to resolve the divergent views about the effectiveness of clonidine in the treatment of Gilles de la Tourette's syndrome.
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001294:Attitude to Health; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005476:Fluphenazine / Q000627:therapeutic use; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010352:Patient Dropouts; D010868:Pimozide / Q000627:therapeutic use; D005879:Tourette Syndrome / Q000188:drug therapy* / Q000523:psychology
chemical_list: D014150:Antipsychotic Agents; D010868:Pimozide; D006220:Haloperidol; D003000:Clonidine; D005476:Fluphenazine