Coordinated synthesis of the nuclear protein cyclin and DNA in serum-stimulated quiescent 3T3 cells.
Quantitative two-dimensional gel electrophoretic analysis (IEF) of the nuclear polypeptide cyclin together with autoradiographic studies have revealed a coordinate synthesis of cyclin and DNA after serum stimulation of quiescent 3T3 cells. These results strengthen the notion that cyclin may be a central component of the pathway(s) that regulate cell proliferation.
D000818:Animals; D001345:Autoradiography; D001769:Blood; D002460:Cell Line; D004261:DNA Replication; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000378:metabolism; D007525:Isoelectric Focusing; D051379:Mice; D009698:Nucleoproteins / Q000096:biosynthesis*; D018809:Proliferating Cell Nuclear Antigen
D009698:Nucleoproteins; D018809:Proliferating Cell Nuclear Antigen