The haemodynamic effects of dopamine and prenalterol in patients after cardiac valve surgery.
The haemodynamic effects of prenalterol and dopamine were compared in 10 patients about 4 h after cardiac valve replacement during a phase of temporarily depressed myocardial function. The rate of infusion was adjusted to give similar increases in stroke volume with the two drugs (dopamine + 17% and prenalterol + 18%). Both drugs produced marked inotropic and chronotropic effects with significant increases in heart rate, cardiac output, arterial blood pressure, and left and right ventricular stroke work. The arterial blood pressure and the left ventricular stroke work increased significantly more with dopamine than with prenalterol, however. The systemic vascular resistance decreased significantly with prenalterol, whereas it was unchanged with dopamine. The effects of prenalterol could be traced after 90 min, whereas the effects of dopamine vanished within 15 min.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery; D006351:Heart Valves / Q000601:surgery*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D011184:Postoperative Period; D011217:Practolol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011294:Prenalterol; D013318:Stroke Volume / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D011294:Prenalterol; D011217:Practolol; D004298:Dopamine