The effect of the dioxolanes on amino acid induced excitation in the mammalian spinal cord.
The effects of the dissociative anaesthetic, etoxadrol, and the stereoisomers of dioxadrol, dexoxadrol and levoxadrol, were examined on the excitation of spinal neurones by electrophoretically administered amino acids in pentobarbitone- or urethane-anaesthetized rats, or pentobarbitone-anaesthetized cats. Both etoxadrol and the (+)isomer of dioxadrol, dexoxadrol, administered locally or systemically, exhibited a selective antagonism of N-methyl-D,L-aspartate relative to quisqualate and kainate. This selective antagonism was not observed with the (-)isomer of dioxadrol, levoxadrol. Since such a stereoselective antagonism of the excitation of spinal neurones by N-methyl-D,L-aspartate is also displayed by the dissociative anaesthetics phencyclidine and ketamine, it is suggested that a reduced efficiency at excitatory synapses utilising N-methyl-D,L-aspartate receptors contributes to that part of the pharmacological spectrum common to both arylcyclohexylamines and dioxolanes.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D002415:Cats; D004148:Dioxolanes / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D007608:Kainic Acid / Q000037:antagonists & inhibitors; D007649:Ketamine / Q000494:pharmacology; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000037:antagonists & inhibitors; D010622:Phencyclidine / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D013045:Species Specificity; D013116:Spinal Cord / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004148:Dioxolanes; D004149:Dioxoles; D010069:Oxadiazoles; D001224:Aspartic Acid; D016202:N-Methylaspartate; D007649:Ketamine; D016318:Quisqualic Acid; D010622:Phencyclidine; D007608:Kainic Acid