Responses of solitary retinal horizontal cells to L-glutamate and kainic acid are antagonized by D-aspartate.
Solitary horizontal cells dissociated from goldfish retinas depolarized when exposed to micromolar doses of either L-glutamate or kainic acid. The responses to both of these agonists were antagonized by D-aspartate, and unaffected by L-aspartate, L-glutamic acid diethyl ester and folic acid. the results of the present study thus suggest that L-glutamate and kainic acid may produce depolarizations of horizontal cells by interacting with pharmacologically similar membrane receptors.
D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D003530:Cyprinidae / Q000033:anatomy & histology*; D018691:Excitatory Amino Acid Antagonists; D005492:Folic Acid / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006054:Goldfish / Q000033:anatomy & histology*; D007395:Interneurons / Q000187:drug effects; D007608:Kainic Acid / Q000037:antagonists & inhibitors*; D011759:Pyrrolidines / Q000037:antagonists & inhibitors*; D012160:Retina / Q000187:drug effects*; D013237:Stereoisomerism
D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D011759:Pyrrolidines; C011829:glutamic acid diethyl ester; D001224:Aspartic Acid; D018698:Glutamic Acid; D005492:Folic Acid; D007608:Kainic Acid