Marrow transplantation for patients in the chronic phase of chronic granulocytic leukaemia.
In 1979 two patients with Philadelphia (Ph1)-chromosome-positive chronic granulocytic leukaemia (CGL) were treated with chemoradiotherapy and transplantation of bone marrow from their respective identical twins. Subsequently twelve patients with Ph1-positive CGL in chronic phase were treated with chemoradiotherapy followed by transplantation of bone marrow from their HLA-identical sibs. Two of the fourteen patients have died of complications of the transplant procedure; twelve patients are alive and well. All the survivors have normal or nearly normal blood counts; there is no evidence of recurrent leukaemia or Ph1-positive cells in any patient after follow-up periods ranging from 97 to 1112 days. Bone-marrow transplantation should be considered in the management of any young patient with CGL who has a suitable marrow donor.
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D016026:Bone Marrow Transplantation; D002648:Child; D002904:Chromosomes, Human, 21-22 and Y; D004359:Drug Therapy, Combination; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics / Q000401:mortality / Q000628:therapy*; D008297:Male; D011183:Postoperative Complications / Q000401:mortality; D011300:Preoperative Care; D011897:Random Allocation; D014185:Transplantation, Isogeneic
D000970:Antineoplastic Agents; D006680:HLA Antigens