Aryl sulfatase A in acute nonlymphocytic leukemia.
To ascertain whether estimation of urinary aryl sulfatase A (ASA) is a reliable noninvasive technique for monitoring disease activity in adult acute nonlymphocytic leukemia, we studied the excretion pattern of this enzyme during active disease, partial remission, and complete remission in ten patients and compared the results with those of ten healthy volunteers. There was no significant difference in enzyme excretion between complete remission cases and the control group. Patients with partial remission and active disease had significantly different urinary enzyme levels from each other and from the control and complete remission groups. Estimation of urinary ASA is a useful noninvasive method of monitoring disease activity in adult acute nonlymphocytic leukemia.
D000208:Acute Disease; D002553:Cerebroside-Sulfatase / Q000652:urine*; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D007938:Leukemia / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D013429:Sulfatases / Q000652:urine*
D013429:Sulfatases; D002553:Cerebroside-Sulfatase