Roles of cyclic nucleotides in the synaptic transmission in sympathetic ganglia of rabbits.
1. Two kinds of slow postsynaptic potentials can be elicitable in the rabbit superior cervical ganglion: a dopaminergic hyperpolarizing (slow IPSP) one and a muscarinic depolarizing (slow EPSP) one, respectively. 2. Cyclic AMP may not be involved in the generation of slow IPSP, whereas it certainly mediates the dopamine-induced enduring modulatory enhancement of the slow EPSP response. 3. Cyclic GMP appears to mediate at least one of the components in the mechanism underlying the slow EPSP by generating a depolarization with no change in membrane conductance. 4. Cyclic GMP does additionally regulate the dopamine for cyclic AMP)-induced modulatory enhancement of the slow EPSP by antagonizing it in a uniquely time-dependent fashion.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004594:Electrophysiology; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009712:Nucleotides, Cyclic / Q000502:physiology*; D011817:Rabbits; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP; D000109:Acetylcholine; D004298:Dopamine