title: Ontogenic restriction of colonization of the bursa of Fabricius.
abstract: The capacity of hemopoietic precursor cells (HPC) to home to embryonic bursal and thymic grafts was investigated in embryonic and newly hatched chickens. Whereas thymic grafts developed normal histogenesis in both types of recipients, the bursal rudiment was colonized and developed in embryonic, but not in newly hatched hosts. In the latter, noncolonized bursal grafts developed neither lymphoid follicles nor granulopoiesis in the mesenchyme. These results are interpreted in terms of ontogenic "maturation" of the HPC which lose their homing potential towards the bursa while they preserve their thymic seeding capacity. This hypothesis is consistent with previously reported data which indicated cyclic continuous recruitment of the thymic lymphoid population, but restricted bursal colonization to a relatively brief period of embryonic life.
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius / Q000166:cytology / Q000276:immunology / Q000637:transplantation*; D002642:Chick Embryo; D002645:Chickens; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000276:immunology; D012867:Skin / Q000276:immunology; D013045:Species Specificity; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D014185:Transplantation, Isogeneic