DNA sequences flanking the insulin gene on chromosome 11 confer risk of atherosclerosis.
The allelic frequency of DNA restriction fragments of a large size class (U alleles) in the polymorphic region flanking the 5'-end of the human insulin gene on chromosome 11 was 2 X 5 times higher in a group of patients with extensive atherosclerosis than in subjects in whom atherosclerosis could not be demonstrated by coronary arteriography and careful clinical examination. The U alleles apparently do not confer risk of atherosclerosis through conventional risk factors such as body weight or blood pressure or levels of blood glucose, triglycerides, cholesterol, or lipoproteins.
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000453:epidemiology / Q000235:genetics*; D001483:Base Sequence; D002906:Chromosomes, Human, 6-12 and X; D003176:Complement C3 / Q000235:genetics; D004247:DNA / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012737:Sex Factors
D003176:Complement C3; D005819:Genetic Markers; D007328:Insulin; D004247:DNA