title: Reduction by two benzodiazepines and pentobarbitone of the multiunit activity in substantia nigra, hippocampus, nucleus locus coeruleus and nucleus raphé dorsalis of encéphale isolé rats.
abstract: Multiunit activity was recorded simultaneously in the substantia nigra pars compacta, the pyramidal layer of the hippocampus dorsalis CA 1 area, the nucleus locus coeruleus and the nucleus raphé dorsalis of encéphale isolé rats; drugs were injected intravenously in increasing doses. Chlordiazepoxide decreased multiunit activity dose-dependently to a similar extent in substantia nigra, hippocampus and dorsal raphé, but was less effective in the locus coeruleus. Midazolam reduced multiunit activity in all 4 nuclei to a similar degree and was more potent than chlordiazepoxide. Specific benzodiazepine antagonists completely reversed the effects of the two benzodiazepines. Pentobarbitone was a less potent depressant than chlordiazepoxide, and its effect was not reversed by the benzodiazepine antagonist Ro 15-1788.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000494:pharmacology*; D001921:Brain / Q000502:physiology; D001933:Brain Stem / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003655:Decerebrate State; D006624:Hippocampus / Q000187:drug effects*; D008125:Locus Coeruleus / Q000187:drug effects*; D008297:Male; D008874:Midazolam; D010424:Pentobarbital / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects*
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D002707:Chlordiazepoxide; D010424:Pentobarbital; D008874:Midazolam