title: Effect of drugs on brain acetylcholine level in Gerbillus pyramidum.
abstract: 1. The quantitative estimation of total acetylcholine content in the whole brain tissue in normal Egyptian gerbil Gerbillus pyramidum, gives an average of 1.43 +/- 0.06 micrograms of acetylcholine chloride/g fresh brain tissue. 2. The brain acetylcholine level in Gerbillus pyramidum was generally found to vary with the changes induced in the brain activity by drugs. 3. Depressants caused a increase and convulsants a decrease in total brain acetylcholine level. 4. Phenytoin depressed the brain activity but lowered brain acetylcholine level.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005849:Gerbillinae; D008297:Male; D008620:Meprobamate / Q000494:pharmacology; D008694:Methamphetamine / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology
chemical_list: D008694:Methamphetamine; D010672:Phenytoin; D009020:Morphine; D012110:Reserpine; D008620:Meprobamate; D010424:Pentobarbital; D000109:Acetylcholine; D010634:Phenobarbital