title: Hypertensive effect of yohimbine following selective injection into the nucleus tractus solitarii of normotensive rats.
abstract: We administered yohimbine (0.5 nmol in 0.2 microliter) directly into the nucleus tractus solitarii (NTS) of urethane-anesthetized normotensive male rats. We noted a prompt rise in blood pressure which lasted 30 min. These data suggest that the NTS is a central site in which the hypertensive effects of yohimbine can originate.
mesh_terms: D000317:Adrenergic alpha-Antagonists; D000818:Animals; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D015016:Yohimbine / Q000494:pharmacology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D015016:Yohimbine