title: Further assessment of benzodiazepine-tricyclic antidepressant interaction. Effectiveness of combined treatment with ketazolam-nortriptyline on conflict behaviour in rats.
abstract: Using Geller and Seifter's conflict behaviour test, ketazolam in rat increases the rate of responses emitted both with and without punishment. Nortriptyline decrease the non-punished component of the schedule without influencing the punished one. With combined treatment, nortriptyline does not modify the effects of ketazolam on punished responses while nortriptyline, 1 h after administration, decreases, though not significantly, the facilitating action of ketazolam. After 24 h it significantly increases the depressant action of this benzodiazepine. The results suggest that with the combination tricyclic anti-depressant-benzodiazepine, as with these two categories of drugs, there is not always an increase in disinhibiting action, while depressant action has characteristics closely dependent on the properties of the benzodiazepine used.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D003220:Conflict, Psychological; D004347:Drug Interactions; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009661:Nortriptyline / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C002072:ketazolam; D009661:Nortriptyline