Monoamine oxidase inhibition by the tremorogenic drug--LON 954.
N-Carbamoyl-2-(2,6-dichlorophenyl)acetamidine HCl (LON 954), a tremorogenic drug, inhibited MAO activity in various tissue preparations in a reversible, competitive manner showing some degree of selectivity towards type-B MAO.
D000818:Animals; D001921:Brain / Q000201:enzymology; D004298:Dopamine / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007700:Kinetics; D008930:Mitochondria, Liver / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D011817:Rabbits; D051381:Rats; D014202:Tremor / Q000139:chemically induced; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; C014908:LON 954; D014508:Urea; D004298:Dopamine