Regulation of phosphoprotein phosphatase by somatostatin.
Cyclic somatostatin inhibited phosphoprotein phosphatase activity in rat liver slices, as well as a partially purified phosphoprotein phosphatase from rat liver. This change was accompanied by a concomitant decrease in cyclic AMP-dependent protein kinase. Studies in vivo showed similar trends in the variation of both enzymes.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D013004:Somatostatin / Q000502:physiology*
D013004:Somatostatin; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases