title: Adrenoreceptor development in rat cerebrum and the effects of ionizing radiation.
abstract: Previous studies in the rat have shown that neonatal radiation alters certain aspects of CNS monoaminergic systems including altering cerebral norepinephrine levels [17]. To determine if cerebral adrenoreceptor development is also altered by neonatal ionizing radiation, a single dose of whole body gamma-radiation was administered to rats on postnatal day two. This treatment did not alter (3H)-dihydroalprenolol (beta adrenoreceptor) or (3H)-WB4101 (alpha1 adrenoreceptor) binding when cerebra from irradiated animals were compared to age-matched sham-irradiated controls on postnatal days 9, 15 and 35. In contrast, (3H)-yohimbine (alpha2-adrenoreceptor) binding was altered in gamma-irradiation, a change manifested on postnatal days 9, 15 and 35 by lower than normal receptor densities (pmoles/g wet weight of tissue) although no radiation-induced changes in KD were apparent.
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000378:metabolism; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000528:radiation effects; D001921:Brain / Q000254:growth & development* / Q000528:radiation effects; D004146:Dioxanes / Q000378:metabolism; D007700:Kinetics; D009929:Organ Size / Q000528:radiation effects; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000528:radiation effects*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism / Q000528:radiation effects*; D015016:Yohimbine / Q000378:metabolism
chemical_list: D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D015016:Yohimbine; C010654:(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane