Relative potencies of the stereoisomers of bethanechol on muscarinic receptor.
The two enantiomers and the racemic form of bethanechol have been synthesized and their muscarinic activities evaluated on isolated rat jejunum. The stereoselectivity observed for bethanechol parallels that previously reported for acetyl-beta-methylcholine and muscarine on the same biological object.
D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001626:Bethanechol Compounds; D011976:Receptors, Muscarinic; D018723:Bethanechol