Serum factor blocking the activity of virus-induced autoreactive T lymphocytes of mice.
Normal mouse serum was found to contain a factor blocking in vivo the effect of autoreactive cells accumulating in spleens of mice infected with tick-borne encephalitis (TBE), Langat, dengue type 2 (D2), and attenuated yellow fever (17D strain) viruses. The activity of the factor was manifested only, when the autoreactive lymphocytes had H-2 antigens identical with H-2 antigens of the serum donors. The hypothesis is discussed that serum factor protects the host against clones of autoreactive T lymphocytes generated in viral infections.
D000818:Animals; D005416:Flavivirus / Q000276:immunology; D006087:Graft vs Host Reaction; D006183:H-2 Antigens / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA / Q000097:blood*; D008815:Mice, Inbred Strains / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014036:Togaviridae Infections / Q000276:immunology*
D006183:H-2 Antigens