The toxic effect of kainic acid on neurotransmitters in nucleus accumbens.
Neurotransmitter parameters (GAD, ChAT, high affinity glutamate uptake and QNB binding) in nucleus accumbens showed a dose-dependent sensitivity towards in situ injections of the toxic agent kainic acid. We found that the effect of kainic acid was only to a small part dependent on the main glutamergic input from the subiculum. The study shows that muscarinic receptors in the nucleus accumbens are mostly located on intrinsic neurons.
D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004296:Dopa Decarboxylase / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects*; D011759:Pyrrolidines / Q000633:toxicity*; D051381:Rats; D011976:Receptors, Muscarinic / Q000378:metabolism; D012686:Septal Nuclei / Q000187:drug effects*; D014316:Tritium
D005971:Glutamates; D018377:Neurotransmitter Agents; D011759:Pyrrolidines; D011976:Receptors, Muscarinic; D014316:Tritium; D018698:Glutamic Acid; D002795:Choline O-Acetyltransferase; D004296:Dopa Decarboxylase; D007608:Kainic Acid