Effect of sympathetic stimulation on salivary secretion in submandibular gland in the rabbit stimulated by pilocarpine.
The sympathetic stimulation under slow pilocarpine-induced flow conditions brought about a decrease in this flow rate that could be due to vasoconstriction, since such an effect was not observed after the administration of phentolamine (4 mg/kg i.v.). Contrariwise the injection of a beta-adrenergic blocking agent (propranolol 2-2.5 mg/kg i.v.) produced a decrease of the salivary flow rate that was even greater than in the control animals. These results suggest that the secretory effect in this gland and species is predominantly beta-adrenergic. The stated results are related to the changes observed in the blood outflow from the gland.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D010646:Phentolamine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D012472:Salivation / Q000187:drug effects; D013363:Submandibular Gland / Q000098:blood supply / Q000294:innervation / Q000378:metabolism*; D014661:Vasoconstriction
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D010862:Pilocarpine; D011433:Propranolol; D010646:Phentolamine