Picrotoxin-like lactones.
Preparation of some simple lactone analogues of picrotoxin and their biological evaluation is reported. Certain analogues possessed activity, but at potencies insufficient to warrant further work.
D000478:Alkylation; D000818:Animals; D000697:Central Nervous System Stimulants / Q000138:chemical synthesis*; D005260:Female; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D010852:Picrotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000697:Central Nervous System Stimulants; D007783:Lactones; D010852:Picrotoxin