Comparison of iohexol with metrizoate in urography. A single blind parallel investigation.
Iohexol 300 and 350 mg I/ml were compared with Na-Ca-Mg metrizoate 350 mg I/ml at the dose levels 200 and 350 mg I/kg body weight. Independent of dosage, iohexol caused a lower incidence of patient reactions during urography than metrizoate. The intensities of the patient reactions in the iohexol groups were consistently milder than those in the corresponding metrizoate groups. Both contrast media gave equally good diagnostic quality, and no unexpected changes in laboratory or physiologic components occurred. Both tolerability and patient reactions indicate that iohexol should be preferred to metrizoate in urography.
D000328:Adult; D000368:Aged; D000626:Aminopeptidases / Q000652:urine; D001794:Blood Pressure / Q000187:drug effects; D018826:CD13 Antigens; D003287:Contrast Media / Q000633:toxicity; D003404:Creatinine / Q000652:urine; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007463:Iodobenzoates; D007472:Iohexol; D008297:Male; D008794:Metrizoic Acid / Q000633:toxicity; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D009325:Nausea / Q000139:chemically induced; D010292:Paresthesia / Q000139:chemically induced; D011897:Random Allocation; D014283:Triiodobenzoic Acids / Q000633:toxicity; D014567:Urography; D014581:Urticaria / Q000139:chemically induced; D014839:Vomiting / Q000139:chemically induced; D001613:beta 2-Microglobulin / Q000652:urine
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D001613:beta 2-Microglobulin; D007472:Iohexol; D003404:Creatinine; D008794:Metrizoic Acid; D000626:Aminopeptidases; D018826:CD13 Antigens