Plasma somatostatin increases during hypoglycaemia in insulin-dependent patients with and without B-cell function.
Responses of somatostatin-like immunoreactivity (SLI) to hypoglycaemia were investigated in seven type 1 (insulin-dependent) patients with residual B-cell function, eight patients without B-cell function, and six healthy controls. A higher basal level of SLI was found in the group with B-cell function when compared with the group without B-cell function. The basal level in the normal subjects was in between the two diabetic groups. All the diabetics had a somatostatin response to hypoglycaemia which was independent of residual B-cell function and no different from that of normal subjects.
D000293:Adolescent; D000328:Adult; D003920:Diabetes Mellitus / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007003:Hypoglycemia / Q000097:blood*; D007332:Insulin Infusion Systems; D007515:Islets of Langerhans / Q000503:physiopathology*; D008297:Male; D013004:Somatostatin / Q000097:blood*
D013004:Somatostatin