Effect of some beta-adrenoceptor blockers and of (+) propranolol on adrenaline-induced pulmonary edema in mice.
(+) Propranolol is considered to prevent adrenaline-induced pulmonary edema (A.P.E.) due to the beta-adrenoceptor blockade. However, local anaesthetics also are known to prevent pulmonary edema. To assess the role of beta-adrenergic blockade in A.P.E., the effect of a beta 1-blocker possessing local anaesthetic action (+/- Metaprolol) and a beta 1-blocker possessing no local anaesthetic action (+/- practolol) was studied along with propranolol derivatives. The study revealed that (+), (-), (+/-) propranolol and (+/-) metaprolol completely prevented A.P.E. whereas (+/-) practolol did not. This shows that local anaesthetic action but not the-beta adrenergic blockade may be responsible for prevention of A.P.E.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006470:Hemorrhage / Q000503:physiopathology; D008297:Male; D051379:Mice; D009929:Organ Size; D011433:Propranolol / Q000494:pharmacology*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology*
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D004837:Epinephrine