Effects of dopaminergic agents on monoamine levels and motor behaviour in planaria.
1. Dopamine, serotonin and, in lesser amounts, norepinephrine were detected in Dugesia gonocephala using electrochemical detection coupled with liquid chromatography (LCED). 2. Treatment with L-dopa induced hyperkinesias, and a rise in dopamine, serotonin and norepinephrine content, whereas reserpine reduced motor activity and the concentrations of all three monoamines. 3. Haloperidol reduced motor activity and dopamine and norepinephrine levels. 4. Apomorphine induced hyperkinesias without altering monoamine levels.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism*; D010932:Planarians / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D014419:Turbellaria / Q000502:physiology*
D012701:Serotonin; D007980:Levodopa; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine