[Effect of melanostatin on the central nervous system].
The effect of melanostatin (MIF), L-DOPA and morphine on the behaviour and electrical activity in the neocortex and lymbic structures in rats has been strudied. All substances were administered intraventricularly. There was a recorded increase of the energy of the delta and theta slow waves in the hypothalamus, amygdala and neocortex and also of the energy of the alfa waves in the amygdala and neocortex. In addition the administration of L-DOPA and morphine facilitated the effect of MIF while preliminary administration of MIF blocked the effect of morphine given in threshold doses.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004357:Drug Synergism; D004569:Electroencephalography; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D010455:Peptides; D004295:Dihydroxyphenylalanine; D009020:Morphine; D009075:MSH Release-Inhibiting Hormone
Vliianie melanostatina na tsentral'nuiu nervnuiu sistemu.