On the character of the electrical activity of the stomach, pyloric sphincter and duodenum of cats.
In cats with chronically implanted electrodes in the muscle wall of the gastro-intestinal tract, the electrical activity of the stomach (S) pyloric sphincter (PS) and duodenum (D) is characterized by cycles consisting of two phases: active--whereby 2 to 3 slow potential changes (SPC) are accompanied by spike potentials (SP) and a pause during which for 60-90 s only SPC are recorded. After bilateral transthoracic vagotomy there is a disruption of the cyclic character of the electrical activity in the investigated regions of the gastro-intestinal tract--SP from S and PS are recorded with each SPC. The active phase of the cycle from D is strongly prolonged at the expense of the shorter pause. This lasts for 1-2 days, after which there is a tendency towards shaping the cycles characteristic of the electrical activity of S, PS and D of cats. The pauses, however remain relatively short and the number of SP in the group is much greater. Gradually during the second month the character of the electrical activity of S, PS, and D approaches that prior to the vagotomy, but even until the 6th month after vagotomy the number of SP in the group is greater and the active phase of the cycle is longer. On the background of antagonists of the adrenoreceptors (propranolol--2 mg/kg and dihydroergotamine--300 micrograms/kg), the cyclic character of the electrical activity of S, PS and D is disturbed. The relatively rapid restoration of the cyclic character of cat S, PS and D after vagotomy is assumed to be the result of the organizing role of the intrinsic nervous system. The disturbance of the cyclic character after adrenoblockers demonstrates the significance of the balance between the cholinergic and adrenergic parts of the intrinsic nervous system for the realization of the cyclic character of the electrical activity of S, PS and D of cats.
D000818:Animals; D002415:Cats; D004087:Dihydroergotamine / Q000494:pharmacology; D004386:Duodenum / Q000294:innervation / Q000502:physiology*; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D011708:Pylorus / Q000294:innervation / Q000502:physiology*; D013270:Stomach / Q000294:innervation / Q000502:physiology*; D014628:Vagotomy
D006584:Hexamethonium Compounds; D018738:Hexamethonium; D004087:Dihydroergotamine; D011433:Propranolol