Adrenocorticotropic hormone causes long-lasting potentiation of transmitter release from frog motor nerve terminals.
Exposure of frog neuromuscular preparations to adrenocorticotropic hormone for several minutes increased both nerve-evoked and spontaneous transmitter release for several hours. No changes in postsynaptic sensitivity to transmitter were detected. The long-lasting potentiation shows little sensitivity to changes in extracellular calcium concentration and seems to be entirely presynaptic in origin.
D000200:Action Potentials / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D002118:Calcium / Q000378:metabolism; D009045:Motor Endplate / Q000187:drug effects*; D009046:Motor Neurons / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats
D018377:Neurotransmitter Agents; D000324:Adrenocorticotropic Hormone; D002118:Calcium