The effect of hyperglycaemia on the rates of appearance and metabolic clearance of glucose in sheep (Ovis aries).
Glucose appearance and utilization before and during glucose infusions were examined in insulin treated alloxan-diabetic (ITA) and intact sheep. During hyperglycaemia in ITA sheep glucose appearance was reduced to 35% of the preinfusion values whereas in intact sheep it was 17% of preinfusion values. Hyperglycaemia per se appears to inhibit glucose appearance. The utilization of glucose was not proportional to glucose concentrations in ITA sheep, but was in intact sheep where insulin concentrations increased during hyperglycaemia.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D008657:Metabolic Clearance Rate; D012756:Sheep / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon