Organ scaling in mammals: the kidneys.
Values of kidney weight in adult male and female mammals, both terrestrial and aquatic, as well as values for renal blood flow and glomerular number and diameter, were submitted to linear (log-log) regression analysis. The slope of the regression line for kidney weight in 63 species of adult terrestrial mammals was 0.85 %/- 0.01. No statistically significant difference was found between the slopes of the regression lines for male and female terrestrial mammals. The slope of regression line for kidney weight in eight species of adult aquatic mammals was 0.92 +/- 0.01. Again, no statistically significant difference was found between the slopes for males and females. However, the slope (0.92) of the regression line for aquatic mammals was significantly different from the slope (0.85) for terrestrial mammals (P much less than 0.001). The slope of the regression of renal blood flow on body weight was 0.82 +/- 0.01. This value is consistent with the hypothesis that renal blood flow represents a constant fraction of cardiac output (over about 3.4 orders of magnitude in body weight). The slopes of the regression lines for glomerular number (per kidney) and mean glomerular diameter were 0.59 +/- 0.02 and 0.11 +/- 0.01, respectively. A schematic model representing the scaling of energy-partitioning in mammals is introduced.
D000818:Animals; D004734:Energy Metabolism; D007668:Kidney / Q000033:anatomy & histology* / Q000378:metabolism; D007678:Kidney Glomerulus / Q000033:anatomy & histology; D008322:Mammals / Q000033:anatomy & histology* / Q000378:metabolism; D009929:Organ Size; D012044:Regression Analysis; D012079:Renal Circulation