Effects of metyrapone on plasma corticosterone concentration in Gallus domesticus.
Metyrapone (75 or 150 mg/kg body wt) was injected into fed and starving birds and their plasma corticosterone concentrations monitored. Metyrapone stimulated a hypercorticosteronaemia in fed but not in starving birds. It persisted for up to 4 hr. No significant hypocorticosteronaemia was noted subsequently. Pretreatment (2 hr) with metyrapone inhibited the response to exogenous ACTH.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002645:Chickens; D003345:Corticosterone / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D012737:Sex Factors; D013217:Starvation / Q000378:metabolism
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone; D008797:Metyrapone