Effect of prolonged beta-adrenoceptor blockade on heart weight and ultrastructure in young rabbits.
1 Young rabbits were treated for 30 days or 6 weeks with propranolol or oxprenolol to provide dose-levels similar to those used clinically. 2 Relative to litter matched controls the treated rabbits exhibited a reduced rate of growth. 3 Morphometric studies showed that prolonged beta-adrenoceptor blockade had no effect on the myofibrillar volume as a proportion of cell volume. 4 Prolonged beta-blockade increased the proportion of the extracellular space occupied by vascular tissue.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005110:Extracellular Space; D006128:Growth / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects; D009206:Myocardium / Q000648:ultrastructure; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits
D000319:Adrenergic beta-Antagonists