Antiviral activity of aryl-furfurane derivatives.
Of 27 aryl-furfurane derivatives (AFD) studied, 13 compounds were found to have antiviral activity against ECHO 6, herpes simplex, vaccinia, and influenza A/Hong Kong/1/68 (H3N2) viruses, the highest inhibition being observed with ECHO 6 virus. The maximum tolerated concentrations (MaTC) of AFD inhibited the macromolecular syntheses in ECHO 6 virus-infected cell cultures.
D000998:Antiviral Agents; D029822:Enterovirus B, Human / Q000187:drug effects; D005663:Furans / Q000494:pharmacology*; D009980:Influenza A virus / Q000187:drug effects; D012367:RNA, Viral / Q000096:biosynthesis; D018139:Simplexvirus / Q000187:drug effects; D014616:Vaccinia virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D005663:Furans; D012367:RNA, Viral