title: Anaerobic vaginosis (non-specific vaginitis): clinical, microbiological, and therapeutic findings.
abstract: The effect of metronidazole on anaerobic vaginosis (non-specific vaginitis) was assessed in a double-blind, placebo-controlled study of 40 women. 19 of 20 women given metronidazole 400 mg twice a day for seven days were clinically and microbiologically cured by the time they completed treatment. All 20 women given a placebo were treatment failures, but when they were given a single 2 g dose of metronidazole, 15 showed clinical and microbiological cure a week later. 14 of the responders showed a recurrence of infection a month after treatment; this was probably due to reinfection, although persistence of infection cannot be ruled out. Findings in the clinic correlated closely with subsequent microbiological results in 133 out of 140 patient-visits, which suggests that there is no need for expensive and time-consuming laboratory investigations in this condition.
mesh_terms: D000332:Aerobiosis; D001421:Bacteria, Anaerobic / Q000302:isolation & purification; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D004311:Double-Blind Method; D005260:Female; D006194:Gardnerella vaginalis / Q000302:isolation & purification; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008795:Metronidazole / Q000627:therapeutic use*; D011897:Random Allocation; D009626:Terminology as Topic; D014621:Vagina / Q000378:metabolism / Q000382:microbiology; D014627:Vaginitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
chemical_list: D008795:Metronidazole