Action of glutamate in the cat labyrinth.
Glutamate solutions of either 50 mM applied on the membranous labyrinth or 1 mM perfused into the lateral canal in cats increased spontaneous and stimulus-evoked activity of vestibular neurons. Kainic acid (10(-4) M) perfused into the labyrinth produced a depolarizing action on vestibular afferents. These results indicate that glutamate could be an excitatory neurotransmitter at the synapse between vestibular hair cells and afferent nerve fibers in the cat.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D007758:Ear, Inner / Q000294:innervation*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology*; D007608:Kainic Acid / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D018377:Neurotransmitter Agents; D013997:Time Factors; D014722:Vestibule, Labyrinth / Q000294:innervation
D005971:Glutamates; D018377:Neurotransmitter Agents; D007608:Kainic Acid