Effects of hypoglycemia on the transmitter pool and the metabolic pool of glutamate in rat brain.
The glutamate terminals in rat neostriatum were removed by unilateral frontal decortication. Insulin-induced hypoglycemia was accompanied by different changes in amino acids in rostral neostriatum on the intact and lesion side. Thus the glutamate/aspartate ratio, glutamate concentration and glutamine concentration were significantly more reduced and the aspartate concentration more elevated on the non-operated than on the operated side. The results show a higher turnover of glutamate in the non-operated side indicating a higher turnover of the transmitter pool than of the metabolic pool of glutamate. The combination of brain lesions with drugs inhibiting the metabolism points to a new method to investigate the compartmentation of glutamate in the mammalian brain.
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D005973:Glutamine / Q000378:metabolism; D007328:Insulin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission
D001786:Blood Glucose; D005971:Glutamates; D007328:Insulin; D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid