Metal-protein binding patterns in the hepatopancreas of the crayfish (Austropotamobius pallipes) during short term cadmium stress.
Cd-binding patterns in the hepatopancreas of the crayfish (Austropotamobius pallipes) have been analysed in response to the administration of a single dose of Cd ions. Four main components, with apparent molecular weights of 3-4, 12, 20 and greater than 70 K daltons, have been isolated from soluble cell fractions. The variation in molar metal/protein ratios of these components is discussed in terms of the uptake, transfer and detoxification of Cd in the hepatopancreas. A model is proposed which describes Cd flux at the subcellular level and indicates that metallothionein-like proteins may mediate in this process.
D000818:Animals; D003400:Astacoidea / Q000378:metabolism*; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D008099:Liver / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism; D011485:Protein Binding; D013347:Subcellular Fractions / Q000378:metabolism; D013997:Time Factors
C004203:cadmium-binding protein; D002104:Cadmium; D008668:Metallothionein