title: Phylogenetic changes in sensitivity to Anemonia sulcata toxin (ATX II), and impact of first interaction with the toxin (imprinting) on later response to it.
abstract: The Anemonia sulcata toxin ATX II is cardiotoxic and neurotoxic, and--at a high dose level--even lethal for the mouse, neurotoxic, but non-lethal for the frog, and has no adverse influence whatever on the Planaria and Tetrahymena; it even stimulates the growth of the Tetrahymena at a low dose level. It also induces imprinting in the Tetrahymena, as judged from the altered response of the latter to ATX II on re-exposure. No similar imprinting effect was demonstrable in mice.
mesh_terms: D000818:Animals; D003064:Cnidarian Venoms / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D051379:Mice / Q000502:physiology*; D009420:Nervous System / Q000187:drug effects*; D010802:Phylogeny; D010932:Planarians / Q000187:drug effects*; D011893:Rana esculenta / Q000502:physiology*; D013045:Species Specificity; D013769:Tetrahymena pyriformis / Q000187:drug effects*; D014419:Turbellaria / Q000187:drug effects*
chemical_list: D003064:Cnidarian Venoms; C028800:toxin II (Anemonia sulcata)