title: Cigarette smoke contains anticoagulants against fibrin aggregation and factor XIIIa in plasma.
abstract: Gas-phase, water-soluble components of cigarette smoke cause delayed fibrin self-assembly and prevent fibrin cross-linking by inactivation of factor XIIIa (plasma transglutaminase). These anticoagulant properties of smoke are demonstrable in plasma, suggesting they play a role in the pathophysiology of smoking.
mesh_terms: D000925:Anticoagulants; D001780:Blood Coagulation Tests; D003432:Cross-Linking Reagents / Q000378:metabolism; D005176:Factor XIII / Q000378:metabolism*; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D010947:Plants, Toxic; D012906:Smoke / Q000032:analysis*; D012907:Smoking; D013918:Thrombin Time; D014026:Nicotiana; D011503:Transglutaminases
chemical_list: D000925:Anticoagulants; D003432:Cross-Linking Reagents; D012906:Smoke; D005337:Fibrin; D005340:Fibrinogen; D005176:Factor XIII; D011503:Transglutaminases