Guanethidine-induced destruction of peripheral sympathetic neurons occurs by an immune-mediated mechanism.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D006145:Guanethidine / Q000494:pharmacology*; D007108:Immune Tolerance / Q000528:radiation effects*; D008297:Male; D009474:Neurons / Q000502:physiology*; D051381:Rats; D011917:Rats, Inbred Lew; D013563:Sympathectomy, Chemical; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D000954:Antigens, Surface; D014446:Tyrosine 3-Monooxygenase; D006145:Guanethidine