Bromoderma caused by carbromalhydroxyzine hydrochloride.
A patient is described who developed a pyoderma-gangrenosum-like ulcer of the leg and acneiform eruption on the face following intake of carbromalhydroxyzine hydrochloride (Dormax). Serum levels of bromide were found to have risen to 105 mg%. There was a return to normal levels of serum bromide and regression of the skin lesions after one week of treatment with natrium chloride and erythromycin. The importance of increasing awareness of the potential hazards of bromide administration is stressed.
D000328:Adult; D001965:Bromides / Q000009:adverse effects; D001966:Bromine / Q000097:blood; D004338:Drug Combinations / Q000009:adverse effects; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000009:adverse effects*; D012871:Skin Diseases / Q000139:chemically induced* / Q000188:drug therapy; D012883:Skin Ulcer / Q000139:chemically induced*; D012965:Sodium Chloride / Q000627:therapeutic use; D014508:Urea / Q000009:adverse effects* / Q000031:analogs & derivatives
D001965:Bromides; D004338:Drug Combinations; C040657:dormax; D006919:Hydroxyzine; D012965:Sodium Chloride; D004917:Erythromycin; D014508:Urea; D001966:Bromine