Biotin enhances guanylate cyclase activity.
Biotin and its analog, (+)-biotin-p-nitrophenyl ester enhanced guanylate cyclase activity two- to threefold in rat liver, kidney, colon, cerebellum, and heart. Dose-response relationships revealed that at concentrations as low as 1 micromolar, both biotin and its analog caused maximal augmentation of guanylate cyclase activity. These data suggest a role for the activation of guanylate cyclase in the mechanism of action of this vitamin.
D000818:Animals; D001710:Biotin / Q000031:analogs & derivatives / Q000494:pharmacology*; D002531:Cerebellum / Q000201:enzymology; D003106:Colon / Q000201:enzymology; D006162:Guanylate Cyclase / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
C002677:biotinyl-4-nitrophenyl ester; D001710:Biotin; D006162:Guanylate Cyclase