[Effect of neuropeptides modulating memory on the background and evoked electrical activity of the cerebral cortex in the rabbit].
The encephalographic correlations of behavioural activity of oligopeptides from the group of memory neuromodulators and similar substances (arginine-vasopressin, a fragment of adrenocorticotropine ACTH4-7 and four its analogues, leu-enkephalin and melanostatine) were studied in rabbits. The encephalogram was activated by these drugs. The fraction of low-frequency components decreased, that of high frequency increased, the amplitude decreased. The effect of ACTH4-7 and vasopressin on the parameters of visual summary evoked potential was dose-dependent. Neuropeptides reduced the latent period and increased the amplitude of summary potentials or depressed these parameters depending on dose. The effects of vasopressin were long-term in nature and lasted for several weeks. The effects of fragments of ACTH and leu-enkephalin lasted for several hours.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects*; D002682:Chinchilla; D004569:Electroencephalography; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D008297:Male; D008568:Memory / Q000502:physiology; D010446:Peptide Fragments / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D013004:Somatostatin / Q000494:pharmacology*; D013997:Time Factors
D010446:Peptide Fragments; D001127:Arginine Vasopressin; C029578:ACTH (4-7); D013004:Somatostatin; D004743:Enkephalin, Leucine; D000324:Adrenocorticotropic Hormone
Izmeneniia fonovoĭ i vyzvannoĭ élektricheskoĭ aktivnosti kory bol'shikh polushariĭ krolika pod vliianiem neĭropeptidov--moduliatorov pamiati.