Cyproterone acetate in treatment of post-orchidectomy hot flushes. Double-blind cross-over trial.
12 patients with troublesome hot flushes after orchidectomy (as a primary treatment for prostatic carcinoma) were treated with cyproterone acetate or placebo in a double-blind cross-over trial. The frequency of hot flushes was significantly reduced during the three weeks that cyproterone acetate (100 mg three times a day) was given. 5 patients complained of lassitude while on cyproterone acetate, but in none was it necessary to discontinue treatment.
D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use*; D002369:Castration / Q000009:adverse effects*; D002979:Climacteric / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017373:Cyproterone Acetate; D004311:Double-Blind Method; D005483:Flushing / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000628:therapy; D011897:Random Allocation
D000726:Androgen Antagonists; D017373:Cyproterone Acetate; D003534:Cyproterone