Comparison of airway obstruction induced by propranolol and YM-09538 (a combined alpha- and beta-adrenoceptor blocking drug).
In the isolated guinea-pig right atria and tracheal strips, both propranolol and YM-09538 caused a parallel shift of the dose-response curve for isoproterenol to the right, indicating that these two drugs block nonselectively the beta 1 1- and beta 2-adrenoceptors. Propranolol potentiated the histamine-induced bronchoconstriction in the anesthetized dogs, whereas YM-09538 did not affect the histamine-induced bronchoconstriction. Propranolol degranulated the isolated rat mesenteric mast cells in contrast to YM-09538 which had no significant effect on mast cells. Neither propranolol nor YM-09538 affected the hapten specific IgE antibody response in female BDF1 mice. These results suggest that YM-09538 has a much lesser effect on airway function than propranolol.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000402:Airway Obstruction / Q000139:chemically induced*; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004205:Cromolyn Sodium / Q000494:pharmacology; D004285:Dogs; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000276:immunology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000096926:Benzenesulfonamides
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004205:Cromolyn Sodium; D004983:Ethanolamines; D007073:Immunoglobulin E; D007545:Isoproterenol; D011433:Propranolol; C032473:amosulalol; D000096926:Benzenesulfonamides