Short-term regulation of hydroxylase cofactor activity in rat brain.
Differential drug effects on hydroxylase cofactor activities were observed in the corpus striatum and the locus coeruleus when conditions of sacrifice were controlled. A conformational stability-dependent variable degree of stoichiometric coupling between quinonoid dihydropteridine reductase and tyrosine hydroxylase is proposed as a short-latency influence on hydroxylase cofactor levels.
D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives / Q000502:physiology*; D002940:Circadian Rhythm; D003342:Corpus Striatum / Q000201:enzymology*; D003913:Dextroamphetamine / Q000494:pharmacology; D007700:Kinetics; D008125:Locus Coeruleus / Q000201:enzymology*; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D010830:Physostigmine / Q000494:pharmacology; D011621:Pteridines / Q000502:physiology*; D011622:Pterins / Q000378:metabolism; D011809:Quinones / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D011621:Pteridines; D011622:Pterins; D011809:Quinones; D001708:Biopterins; D012110:Reserpine; D010830:Physostigmine; D010088:Oxidoreductases; C022513:quinonoid dihydropterin reductase; D014446:Tyrosine 3-Monooxygenase; C003402:sapropterin; D003913:Dextroamphetamine