title: Some properties of monoamine oxidase in carp heart.
abstract: Studies using clorgyline, deprenyl and semicarbazide as inhibitors showed that carp heart homogenate contained a new type of monoamine oxidase (MAO) and a clorgyline- and deprenyl-resistant amine oxidase (CRAO). The deamination of monoamines by carp heart MAO proceeded in two steps by a double-displacement (ping-pong) mechanism. The Km values of the MAO for oxygen (K0 values) with tyramine, 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA) as substrates were identical (59 microM).
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism*; D003010:Clorgyline / Q000494:pharmacology; D003530:Cyprinidae / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008995:Monoamine Oxidase / Q000032:analysis* / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors; D009124:Muscle Proteins / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D012642:Selegiline / Q000494:pharmacology; D013379:Substrate Specificity / Q000187:drug effects
chemical_list: D008996:Monoamine Oxidase Inhibitors; D009124:Muscle Proteins; D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline