Hepatic enzyme induction patterns and phenothiazine side effects.
D-Glucaric acid excretion was followed in psychotic patients treated with phenothiazines for 12 days and in a control group of subjects who had no psychiatric disease. About half the psychiatric patients had a treatment-related rise in D-glucaric acid excretion compatible with enzyme induction. These patients had fewer and less severe neurologic side effects than those who did not have a significant rise in urinary D-glucaric acid levels. It is concluded that individual differences in metabolism of phenothiazines may in part account for the variability in clinical response to these drugs.
D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005937:Glucaric Acid / Q000652:urine*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines; D011618:Psychotic Disorders / Q000188:drug therapy*; D013400:Sugar Acids / Q000652:urine*
D014150:Antipsychotic Agents; D010640:Phenothiazines; D013400:Sugar Acids; D005937:Glucaric Acid