title: [Acute transformation of chronic myeloid leukemia: disappearance of the Philadelphia chromosome after autograft].
abstract: Two patients with chronic granulocytic leukemia (C.G.L.) undergoing transformation were treated by high dose chemotherapy and total body irradiation followed by autografting of hematopoietic stem cells collected and cryo-preserved at the time of diagnosis. Recovery of hematopoiesis was characterized by disappearance of the Philadelphia chromosome in most metaphases. A new approach of the management of C.G.L. is discussed.
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002904:Chromosomes, Human, 21-22 and Y; D003131:Combined Modality Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008938:Mitosis; D011379:Prognosis; D014916:Whole-Body Irradiation
vernacular_title: Transformation aiguë de leucémie myéloïde chronique: disparition du chromosome Philadelphie après autogreffe.