Tropolone antagonism of the L-dopa-induced elevation of S-adenosylhomocysteine: S-adenosylmethionine ratio but not depletion of adrenaline in rat hypothalamus.
Tropolone, an inhibitor of catechol O-methyl transferase, largely prevented the increase in SAH : SAMe ratio in rat hypothalamus following L-dopa injection. Tropolone did not prevent but instead enhanced the decrease produced by L-dopa of adrenaline concentration in rat hypothalamus. The results imply that the decrease in hypothalamic adrenaline concentration following L-dopa injection was not caused by the increase in SAH : SAMe ratio.
D000818:Animals; D065098:Catechol O-Methyltransferase Inhibitors; D004837:Epinephrine / Q000378:metabolism*; D006710:Homocysteine / Q000031:analogs & derivatives*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007980:Levodopa / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012435:S-Adenosylhomocysteine / Q000378:metabolism*; D012436:S-Adenosylmethionine / Q000378:metabolism*; D014334:Tropolone / Q000494:pharmacology
D065098:Catechol O-Methyltransferase Inhibitors; D006710:Homocysteine; D007980:Levodopa; D014334:Tropolone; D012436:S-Adenosylmethionine; D012435:S-Adenosylhomocysteine; D004837:Epinephrine