title: Determinants of systemic availability of promethazine in rabbits.
abstract: Promethazine blood concentration-time curves have been determined in 7 rabbits following intravenous, oral and hepatic portal vein administration of promethazine. This phenothiazine has a large volume of distribution and a high metabolic clearance resulting in low blood concentrations particularly when the oral route is used. Analysis of the areas under the blood concentration-time curves indicates that hepatic first-pass metabolism is the major determinant of promethazine's low oral availability. Absorption from the gastrointestinal tract is essentially complete in most rabbits and the contribution of metabolism by the intestinal mucosa is minimal. The present findings are compared with the literature on other phenothiazines.
mesh_terms: D000818:Animals; D001682:Biological Availability; D006207:Half-Life; D007408:Intestinal Absorption; D008297:Male; D011398:Promethazine / Q000378:metabolism*; D011817:Rabbits
chemical_list: D011398:Promethazine