title: Neonatal nesidioblastosis--diagnosis and preoperative management.
abstract: Two infants were admitted for severe, intractable hypoglycemia. "Fasting" tests lasting 45 and 30 minutes respectively revealed hypoglycemia with inappropriately elevated levels of plasma insulin and plasma C-peptide. Subsequently, somatostatin was infused to test the individual sensitivity of the B-cells. Basal and glucose-induced insulin and C-peptide secretion were significantly reduced. Preoperative treatment with somatostatin was introduced, which controlled the hypoglycemia. In both patients, subtotal pancreatectomy was effective in restoring normal glucose homeostasis.
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006946:Hyperinsulinism / Q000175:diagnosis; D007003:Hypoglycemia / Q000175:diagnosis; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D010182:Pancreatic Diseases / Q000151:congenital* / Q000175:diagnosis / Q000601:surgery; D011300:Preoperative Care; D013004:Somatostatin
chemical_list: D001786:Blood Glucose; D013004:Somatostatin; D005947:Glucose