Immunohistochemical distribution of pro-somatostatin-related peptides in hippocampus.
By using immune sera which recognize one or more of the 3 peptides, somatostatin-14 (SS14), somatostatin-28 (SS28) and somatostatin-28(1-12) (SS28(1-12)) we have characterized their immunohistochemical distribution in the hippocampal formation. There exist at least two independent neuronal systems containing pro-somatostatin-related peptides: an intrinsic system of cells in the polymorphic layers which branch locally, and a dense terminal field in the molecular layer of the dentate gyrus that may constitute a portion of the entorhinal-dentate projection. In addition, SS28 is the dominant form present in cell bodies, whereas SS28(1-12) is preferentially localized in neuronal processes and terminals. We could not detect SS14 immunohistochemically.
D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000276:immunology*; D006651:Histocytochemistry; D007106:Immune Sera / Q000276:immunology; D007158:Immunologic Techniques; D009474:Neurons / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D051381:Rats; D013004:Somatostatin / Q000276:immunology*; D053561:Somatostatin-28; D014018:Tissue Distribution
D007106:Immune Sera; D010446:Peptide Fragments; D013004:Somatostatin; D053561:Somatostatin-28; C037197:somatostatin 28-(1-12)