[Effects of dithiocarbamate: "in vitro" and "in vivo" changes in gamma-glutamyltransferase induced by sodium diethyldithiocarbamate].
Experiments of NaDDTC effect on kidney and 10,000 X g liver supernatant fraction have shown no modification of normal GGT activity, also after dialysis. A decrease of about 75% of the GGT activity was observed in rabbit 10,000 X g liver supernatant fraction after i.p. treatment with 100 mg/kg of NaDDTC for three days. It is suggested that liver MFO produces SH groups derived from NaDDTC metabolism able to interact with GGT and consequential inactivation of the enzyme.
D000818:Animals; D004050:Ditiocarb / Q000031:analogs & derivatives / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D011817:Rabbits; D013859:Thiocarbamates / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D013859:Thiocarbamates; D004050:Ditiocarb; D005723:gamma-Glutamyltransferase
Azione dei ditiocarbamati (DTC): alterazioni della gamma-glutamiltransferasi (GGT) "in vitro" ed "in vivo" indotte da sodiodietilditiocarbamato (NaDDTC).