Negative inotropic effect of some H2-receptor antagonists on the isolated human atria.
H2-Receptor antagonists were found to possess in various degrees a negative inotropic effect on human atria in vitro. This effect seemed to be independent of H2-receptor blockade and, at least in the case of oxmetidine, seemed to involve calcium ion transport and/or utilization.
D002118:Calcium / Q000494:pharmacology; D002927:Cimetidine / Q000031:analogs & derivatives / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006325:Heart Atria; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D011744:Pyrimidinones / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D007093:Imidazoles; D011744:Pyrimidinones; C039796:mifentidine; C033275:SK&F 93479; D002927:Cimetidine; D014700:Verapamil; C023990:tiotidine; D002118:Calcium; C027703:oxmetidine