title: [Catecholamine metabolism and mitochondrial enzyme activity].
abstract: Specific effects of various catecholamines as well as functional dependence of mitochondrial enzymes activity on catecholamine metabolism were studied. Dopamine activated cytochrome c oxidase in heart mitochondria and decreased this enzymatic activity in liver tissue. Noradrenaline and adrenaline activated cytochrome c oxidase in liver, brain and kidney tissues. The effect of dopamine on cytochrome c oxidase was prevented by activation of dopamine beta-hydroxylase. Increased activity of monoamine oxidase caused accumulation of catecholamine metabolites, which inhibited the succinate dehydrogenase activity in liver tissue and the cytochrome c oxidase activity in brain, kidney and liver tissues. In the catecholamine regulation of succinate dehydrogenase and ATPase activities in all the tissues studied as well as of cytochrome c oxidase activity in heart tissue the quinoid oxidation products were apparently involved.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000323:Adrenochrome / Q000494:pharmacology; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D002395:Catecholamines / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D003576:Electron Transport Complex IV / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D009638:Norepinephrine / Q000494:pharmacology; D009928:Organ Specificity; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D000323:Adrenochrome; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
vernacular_title: Metabolizm katekholaminov i aktivnost' fermentov mitokhondriĭ.