Beneficial effect of a low-fat low-calorie diet on myocardial energy metabolism in patients with angina pectoris.
8 patients with exertional angina pectoris were treated for 3 months with a low-fat, low-calorie diet. Serum cholesterol was reduced by 28% and body-weight by 7.9 kg on average. The effect of the dietary intervention was assessed by a heart metabolic study during pacing-induced tachycardia. After dietary treatment coronary sinus blood-flow and myocardial oxygen consumption were considerably reduced, but pacing time before angina developed increased. Other improvements were a reduction in lactate release during pacing, a reduction in citrate release during recovery, a reduction in alanine output during rest and recovery, and a lower uptake of glutamate. The results suggest a beneficial effect of low-fat, low-calorie dietary treatment on myocardial energy metabolism in patients with exertional angina pectoris.
D000409:Alanine / Q000378:metabolism; D000787:Angina Pectoris / Q000178:diet therapy* / Q000378:metabolism / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D004734:Energy Metabolism; D005971:Glutamates / Q000378:metabolism; D006339:Heart Rate; D006801:Humans; D007773:Lactates / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption
D002951:Citrates; D004041:Dietary Fats; D005971:Glutamates; D007773:Lactates; D019343:Citric Acid; D000409:Alanine