Antisickling effects of membrane-interacting compounds.
Several anti-psychotic drugs were found to have an in vitro antisickling effect. A linear relationship was found between the antisickling activity and the inhibition of calmodulin stimulated phosphodiesterase activity. These membrane-interacting compounds produce a "cup-shaped" red blood cell at the concentration where they demonstrate an antisickling effect. The volume of a "cup-shaped" red cell (with chlorpromazine) does not change significantly from that of an untreated control red cell. The anti-sickling mechanism of these membrane-interacting compounds is not known at this point.
D000755:Anemia, Sickle Cell / Q000097:blood; D014150:Antipsychotic Agents / Q000494:pharmacology*; D000986:Antisickling Agents / Q000494:pharmacology*; D002147:Calmodulin / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D004913:Erythrocytes, Abnormal / Q000187:drug effects*; D006801:Humans; D013449:Sulfonamides / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D014150:Antipsychotic Agents; D000986:Antisickling Agents; D002147:Calmodulin; D013449:Sulfonamides; D014665:Vasodilator Agents; C017967:W 7; D002746:Chlorpromazine