The effect of alpha- and beta-receptor blocking agents on gastric acid secretion in guinea-pigs.
The effects of alpha- and beta-receptor blocking agents on gastric acid secretion were tested on 95 female guinea-pigs. Alpha blockade insignificantly inhibited the gastric acid secretion in the unstimulated animals, whereas in those stimulated with histamine, significant reduction was seen. Beta blockade had no influence on gastric secretion in the unstimulated animals but significantly enhanced the histamine-stimulated secretion of acid.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D010643:Phenoxybenzamine; D006632:Histamine; D011433:Propranolol