2-Benzazepines. 2. Thiazolo[5,4-d][2]benzazepines.
As part of a program in the area of annelated 2-benzazepines, several thiazolo[5,4-d))[2]benzazepines were prepared. Treatment of the bromo ketones 7-9 with various thio amides gave the thiazoles 10-15, which when treated with methylamine gave the title compounds. The preliminary pharmacology of these compounds showed that they had central nervous system activity similar to the 1,4-benzodiazepines, such as diazepam. The thiazolo[5,4-d][2]benzazepines were also found to bind to the benzodiazepine-receptor complex, indicating that their pharmacological actions are probably related to the 1,4-benzodiazepines.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis*; D001552:Benzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001667:Binding, Competitive; D055598:Chemical Phenomena; D002621:Chemistry; D003975:Diazepam / Q000378:metabolism; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors
D014151:Anti-Anxiety Agents; D001552:Benzazepines; D003975:Diazepam; D010433:Pentylenetetrazole