Behavioral pharmacologic studies in the monkey with DD-3480.
A comparative study has been made of the catalepsy-inducing and antiapomorphine effects of DD-3480, a new butyrophenone derivative, and haloperidol in monkeys. DD-3480 exhibited catalepsy-inducing effects in a dose-dependent manner at oral doses of 2.5-10 mg/kg. This effect was comparable to that of haloperidol, but its duration was shorter in DD-3480 than in haloperidol. An evident anti-apomorphine effect was observed at 2.5 mg/kg of DD-3480 (p.o.); it was slightly stronger than that of haloperidol.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002090:Butyrophenones / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008252:Macaca fascicularis; D008253:Macaca mulatta; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D014150:Antipsychotic Agents; D002090:Butyrophenones; D011954:Receptors, Dopamine; C024159:timiperone; D006220:Haloperidol; D001058:Apomorphine