Low doses of somatostatin do not suppress postprandial serum gastrin levels in dogs.
MUe effect of 0.1, 0.4, 1.0, 2.0 and 5.0 micrograms kg-1 h-1 somatostatin on food-induced rise of serum gastrin concentrations was studied in 4 dogs. Whereas it has been shown previously that these doses of somatostatin reduce postprandial release of other gastroenteropancreatic hormones, there was no evidence of suppression of serum gastrin levels. A dose of 12.6 micrograms kg-1 h-1 somatostatin abolished the gastrin response completely. The study shows that low doses of somatostatin are not a uniform suppressor of gastroenteropancreatic hormones.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004435:Eating; D005260:Female; D005755:Gastrins / Q000097:blood*; D008832:Microchemistry; D013004:Somatostatin / Q000494:pharmacology*
D005755:Gastrins; D013004:Somatostatin