Decrease in N-acetyl-L-aspartic acid in brain of myodystrophic mice.
Brain tissue from myodystrophic mice (male 129/ReJ-dy and female 129 B6F1/J-dy) was examined to determine whether CNS abnormalities accompany the known muscular defects. Brain N-acetyl-L-aspartate, aspartate, and glutamate were significantly lower than in brain from control mice. These amino acids are only slightly reduced in brains of female dystrophic mice.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D005260:Female; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D012737:Sex Factors
D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; C000179:N-acetylaspartate