Ataranalgesia. A review.
A review is given of the pharmacodynamic effects of Ketamine and the commonly used Benzodiazepines especially regarding the clinical application of the substances in combination as socalled ataranalgesia. The literature as well as own experimental results show the advantages of ataranalgetic combinations for induction and maintenance of general anesthesia. Special comment is given for new results about the reversal of hypnotic action by means of 4-aminopyridine.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology; D000758:Anesthesia / Q000379:methods*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001569:Benzodiazepines; D004338:Drug Combinations; D006321:Heart / Q000187:drug effects; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D009469:Neuromuscular Junction / Q000187:drug effects
D000631:Aminopyridines; D014151:Anti-Anxiety Agents; D004338:Drug Combinations; D001569:Benzodiazepines; D007649:Ketamine; D015761:4-Aminopyridine