Rectal absorption of some glycosaminoglycan sulphates and heparin in rats.
A standardized extract of glycosaminoglycan sulphates containing heparin, with a low affinity for antithrombin III, and a commercial heparin were administered to rats, by the rectal route. When the glycosaminoglycan sulphates were given in oil emulsion with sodium laurylsarcosinate as surfactant, 1 mg kg-1 and 3 mg kg-1 were sufficient for the clearing and anticoagulant activities, respectively. The rectal absorption of glycosaminoglycans after dosing with a suitable 'promoter' produced dose-dependent effects and their kinetics were comparable to those obtained after intramuscular administration. The oil emulsion improved the bioavailability of glycosaminoglycan sulphates at least 20 times.
D000042:Absorption; D000818:Animals; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000494:pharmacology; D014677:Pharmaceutical Vehicles; D051381:Rats; D012007:Rectum / Q000378:metabolism*
D006025:Glycosaminoglycans; D014677:Pharmaceutical Vehicles; D006493:Heparin; D008071:Lipoprotein Lipase