Contribution of the genetic status of oxidative metabolism to variability in the plasma concentrations of beta-adrenoceptor blocking agents.
The oxidative metabolism of bufuralol is under the same genetic control as that of debrisoquine and sparteine. 154 fasting volunteers received a 30 mg tablet of bufuralol and a blood sample was taken 3 h later. In poor metabolizers (8% of the sample) the plasma bufuralol concentrations were very high and the metabolite concentrations were low. The genetic oxidative status is a major source of interindividual variation in the plasma concentration of drugs that undergo oxidative metabolism.
D000319:Adrenergic beta-Antagonists / Q000097:blood*; D000328:Adult; D004983:Ethanolamines / Q000097:blood; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D000432:Methanol / Q000097:blood; D010084:Oxidation-Reduction; D010641:Phenotype
D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; C010831:bufuralol; D000432:Methanol