Indirect adrenergic effect of histamine in human cerebral arteries: influence of post-mortem period.
Histamine (10(-4) M) increased the radioactivity released from human cerebral arteries obtained within 6 h of death and preincubated with [3H]noradrenaline. In the presence of 10(-6) M cocaine or if 7 or more hours had elapsed since death, 10(-4) M histamine was unable to change basal levels of tritium outflow. The radioactivity retained by the tissue was higher when cerebral blood vessels were obtained within a post-mortem period of 6 h. These results suggest that histamine may release noradrenaline from the sympathetic innervation of human cerebral arteries and that the function of this innervation lasts only 6 h after death.
D000328:Adult; D000368:Aged; D002536:Cerebral Arteries / Q000187:drug effects*; D002648:Child; D003042:Cocaine / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D011180:Postmortem Changes; D013564:Sympathetic Nervous System / Q000187:drug effects*
D006632:Histamine; D003042:Cocaine; D009638:Norepinephrine