Effect of benzodiazepine derivatives on amygdaloid-kindled convulsion.
An evaluation of the anticonvulsant effect of five kinds of benzodiazepine derivatives using amygdaloid-kindled rats yielded the following pharmacological properties of benzodiazepine derivatives: (1) Bromazepam, lorazepam and nitrazepam block the behavioral seizure response and also shorten the after-discharge duration simultaneously in both primary and secondary epileptogenic foci. (2) Diazepam has little effect on shortening the after-discharge duration at least in the primary epileptogenic focus though it blocks the behavioral seizure response. (3) Although clonazepam can block the behavioral seizure response and shorten the after-discharge duration, further investigations are necessary to define its efficacy.
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants; D001960:Bromazepam / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000187:drug effects*; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D009567:Nitrazepam / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002998:Clonazepam; D009567:Nitrazepam; D008140:Lorazepam; D003975:Diazepam; D001960:Bromazepam