Synthesis of the nuclear protein cyclin in growing, senescent and morphologically transformed human skin fibroblasts.
Quantitative two-dimensional gel electrophoretic analysis (IEF) of the nuclear polypeptide cyclin in normal human skin biopsies, growing and senescent fibroblasts and morphologically transformed skin fibroblasts (limited life span) has revealed a direct correlation between the levels of this protein and proliferative state of the cells. These results strengthen the notion that cyclin may be a key component of the pathway(s) that control cell proliferation.
D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism*; D002470:Cell Survival; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D007525:Isoelectric Focusing; D009698:Nucleoproteins / Q000096:biosynthesis*; D018809:Proliferating Cell Nuclear Antigen; D012867:Skin / Q000166:cytology
D009698:Nucleoproteins; D018809:Proliferating Cell Nuclear Antigen