[Hyperthermia with acute rhabdomyolysis in a psychotic treated with neuroleptics].
A 36 year old psychotic man receiving treatment with slow-release pipotiazine and trihexyphenidyl developed nine days after addition of droperidol signs suggestive of a malignant neuroleptic syndrome: altered general condition, diffuse hypertonia, akinesia, fever and vomiting. Results of biologic tests and a muscle biopsy were suggestive of a severe rhabdomyolysis. Cessation of neuroleptic therapy and the administrative of nifedipine brought a gradual return return to normal conditions, and progressively increasing doses of neuroleptic could be given without complications 12 days later. Onset of hyperthermia during neuroleptic treatment raises two questions: 1) is the etiology related to a malignant neuroleptic syndrome or acute catatonia, or a heat stroke? 2) to what extent are neuroleptics responsible for these disorders?
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D004329:Droperidol / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use; D010640:Phenothiazines / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000188:drug therapy; D012562:Schizophrenia, Disorganized / Q000188:drug therapy; D014282:Trihexyphenidyl / Q000009:adverse effects*
D014150:Antipsychotic Agents; D010640:Phenothiazines; D014282:Trihexyphenidyl; D009543:Nifedipine; D004329:Droperidol
Hyperthermie avec rhabdomyolyse aiguë chez un psychotique traité par neuroleptiques.