title: Somatostatin-like immunoreactive neurons in the hippocampus: an immunocytochemical study in the rat.
abstract: Using antibodies to somatostatin in combination with the avidin-biotin immunohistochemical method, the laminar distribution and morphology of somatostatin-like (SOM-L) immunoreactive cells have been studied in the hippocampal formation of the rat. SOM-L positive cells are present throughout the longitudinal axis of the hippocampus. Most of these neurons are of medium (15-20 micrometers) to large (25-30 micrometers) size with soma of multipolar or fusiform shape. No pyramidal or granule cells contained SOM-L immunoreactivity. SOM-L-positive cells show a preferential distribution in the stratum oriens and stratum pyramidalae of Ammon's horn, and match the description of the polymorphic cells of the hilus area dentata. This geographic segregation may imply a chemical compartmentation of function in the hippocampus.
mesh_terms: D000818:Animals; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*
chemical_list: D010455:Peptides; C029993:somatostatin-like peptides; D013004:Somatostatin