Effects of antianxiety and antipsychotic drugs on DRL responding for brain stimulation.
Satiated rats could be trained to give stable rates of responding for rewarding stimulation of the lateral hypothalamus delivered on differential reinforcement of low rate (DRL) schedule requiring 2 to 8 sec interresponse intervals for reinforcement (DRL-2 to 8). The performance on a DRL-8 schedule was tested 30 min after the oral administration of benzodiazepines. Diazepam (5 and 10 mg/kg) and meprobamate (200 mg/kg) caused significant increases in response rates during the first 5 min of a session, but not thereafter. Bromazepam (1 and 5 mg/kg) also caused a significant increase in the rates during the first and second 5 min. On the other hand, chlorpromazine (20 mg/kg) caused no effect in the first 5 min but decrease in second and third 5 min. These results indicate that DRL schedules with a brain stimulation reward provided a useful tool for evaluation of antianxiety drugs. The advantage of the brain stimulation reward over food reward is that the possible effects of the drugs on hunger motivation need not be considered.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001960:Bromazepam / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D008297:Male; D008620:Meprobamate / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D008620:Meprobamate; D003975:Diazepam; D002746:Chlorpromazine; D001960:Bromazepam