Acidosis lowers in-vivo potency of narcotics and narcotic antagonists and can even abolish narcotic antagonist activity.
D000138:Acidosis / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009292:Narcotic Antagonists / Q000378:metabolism / Q000494:pharmacology*; D009294:Narcotics / Q000378:metabolism / Q000494:pharmacology*; D012995:Solubility
D009292:Narcotic Antagonists; D009294:Narcotics