title: Clinical studies with terfenadine in seasonal allergic rhinitis in France.
abstract: The results of a multicentre investigation carried out on 312 pollinic patients are presented. Efficacy of alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1- piperidinebutanol (terfenadine, RMI 9918, Triludan, Teldane, resp.) has been estimated from a global appreciation and the evolution of 11 symptoms, and tolerance on the frequency of diurnal sleepiness. The results showed a very good efficacy of terfenadine and the absence of a depressant effect.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002744:Chlorpheniramine / Q000009:adverse effects / Q000627:therapeutic use; D002940:Circadian Rhythm; D005260:Female; D005602:France; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008875:Middle Aged; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*; D016593:Terfenadine
chemical_list: D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; D006993:Hypnotics and Sedatives; C018904:dexchlorpheniramine; D002744:Chlorpheniramine; D016593:Terfenadine