Isolation and structure of guinea pig gastric and pancreatic somatostatin.
Somatostatin-14 has been isolated from guinea pig pancreas and stomach and purified to homogeneity by gel filtration, ion-exchange chromatography and reverse phase HPLC. Amino acid composition and sequence analysis indicated that guinea pig somatostatin from both tissues has the same structure as somatostatin-14 from all other mammalian species yet studied. The study has demonstrated that somatostatin-14 from gastric tissue has the same structure as the peptide from hypothalamus and pancreas.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D006168:Guinea Pigs; D007031:Hypothalamus / Q000032:analysis; D010179:Pancreas / Q000032:analysis*; D013004:Somatostatin / Q000302:isolation & purification*; D013270:Stomach / Q000032:analysis*
D000596:Amino Acids; D013004:Somatostatin