Correlation between reproductive and interfering activities of epidemic and thermosensitive influenza virus strains.
Differences in interfering activities were demonstrated between low-passage epidemic and thermosensitive cold-adapted strains of influenza viruses A and B in experiments on chick embryos inoculated on the chorioallantoic membranes and on white mice. At a high multiplicity of infection the thermosensitive variants showed a higher interfering activity as compared with the original viruses which had undergone a limited number of chick embryo passages.
D000818:Animals; D002642:Chick Embryo; D006387:Hemagglutination, Viral; D006358:Hot Temperature; D051379:Mice; D009975:Orthomyxoviridae / Q000472:pathogenicity / Q000502:physiology*; D014762:Viral Interference; D014774:Virulence; D014779:Virus Replication