Possible association between DNA sequences flanking the insulin gene and atherosclerosis.
The proportion of subjects homozygous for DNA restriction fragments of a large size class (U alleles), in the polymorphic region flanking the 5' end of the insulin gene of chromosome 11, was higher in a group of non-insulin-dependent diabetic (NIDDM) patients than in normal controls. This finding confirms that the U allele is associated with at least one form of NIDDM. The U alleles were also found to be strongly associated with macroangiopathy in diabetic as well as in non-diabetic subjects. Thus, DNA sequences contained in the U alleles might be associated with the development of atherosclerosis in an as yet unknown way.
D000483:Alleles; D001161:Arteriosclerosis / Q000235:genetics*; D002906:Chromosomes, Human, 6-12 and X; D004262:DNA Restriction Enzymes; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000235:genetics; D003925:Diabetic Angiopathies / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007328:Insulin / Q000235:genetics* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D007328:Insulin; D004262:DNA Restriction Enzymes