Studies into the mode of action of non-steroidal anti-inflammatory drugs using a model of facsimile synovium.
The effect of non-steroidal anti-inflammation produced in the 6-day old air pouch by carrageenan or calcium pyrophosphate crystals has been examined. The system is a very reproducible way of studying the cellular and vascular components of inflammation. Non-steroidal drugs have different profiles of activity when tested on the inflammation produced with the two irritants. In general, however, the tested compounds showed similar activity on individual models.
D000388:Air; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002131:Calcium Pyrophosphate; D002351:Carrageenan; D004195:Disease Models, Animal; D007509:Irritants; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013583:Synovial Membrane / Q000187:drug effects*; D013585:Synovitis / Q000139:chemically induced / Q000503:physiopathology; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D007509:Irritants; D002351:Carrageenan; D002131:Calcium Pyrophosphate