Endothelium-dependent vasodilator-and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation.
D000818:Animals; D001013:Aorta, Thoracic; D006152:Cyclic GMP / Q000096:biosynthesis* / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D004727:Endothelium / Q000502:physiology*; D004789:Enzyme Activation; D006162:Guanylate Cyclase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D014664:Vasodilation; D014665:Vasodilator Agents / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D010750:Phosphoproteins; D014665:Vasodilator Agents; D009599:Nitroprusside; D010741:Phospholipases A; D006162:Guanylate Cyclase; D006152:Cyclic GMP