The role of general practitioner research groups in the study of benzodiazepines.
The advantages of a once a day regime of a long half life benzodiazepine are illustrated by a general pratitioner study in the U.K., which showed that in a group of over 100 patients, clorazepate 15 mg nocte was equally as effective as diazepam 5 mg three times a day. Another study carried out on 50 patients randomly allocated to lorazepam 1 mg t.d.s. or to clorazepate, which was directly related to the low incidence of side effects and simplicity of dosage.
D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001007:Anxiety / Q000188:drug therapy*; D002986:Clinical Trials as Topic / Q000379:methods; D003009:Clorazepate Dipotassium / Q000008:administration & dosage* / Q000009:adverse effects; D003975:Diazepam / Q000008:administration & dosage*; D005194:Family Practice; D006207:Half-Life; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy
D014151:Anti-Anxiety Agents; D003009:Clorazepate Dipotassium; D008140:Lorazepam; D003975:Diazepam