Effect of L-dopa on glutamate decarboxylase activity in the hypothalamic and amygdaloid nuclei.
Repeated administration of L-dopa methylester produced a significant increase in glutamate decarboxylase (GAD) activity without pyridoxal-5'-phosphate in the lateral hypothalamic area and medial amygdaloid nucleus. The effect of L-dopa on GAD activity was opposite to that of haloperidol in the lateral hypothalamic area.
D000679:Amygdala / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007980:Levodopa; D011732:Pyridoxal Phosphate; D005968:Glutamate Decarboxylase; D006220:Haloperidol