[Effect of emotional pain stress on Na, K-ATPase activity in the myocardium].
Emotional-pain stress results in a 25% decrease in Na K-ATPase activity in the heart. Injection of beta-adreno-blocker inderal in a dose of 1 mg/Kg bw 10 minutes before exposure to stress completely averts and decrease in the enzyme activity. This effect of inderal may be due to the inhibition of catecholamines which release in abundance during emotional-pain stress and which can indirectly damage the sarcolemma by means of lipid peroxidation activation.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D006321:Heart / Q000187:drug effects; D006801:Humans; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D010146:Pain / Q000201:enzymology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013315:Stress, Psychological / Q000201:enzymology*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D000254:Sodium-Potassium-Exchanging ATPase
Vliianie émotsional'no-bolevogo stressa na aktivnost' Na, K-ATF-azy v serdechnoĭ myshtse.