[Ionic mechanisms of depolarization responses induced by glutamate application to nerve cells of Helix pomatia].
The reversal potentials for transmembrane ionic currents induced by glutamate were measured in different D-neurons of the snail Helix pomatia. The first group of neurons had a mean reversal potential--10.6 +/- 1.2 mV and the second one--40.0 +/- 0.6 mV. Under normal conditions glutamate evoked spike discharges in the first group of neurons but not in the second one. At higher concentrations of glutamate the amplitude of D-responses in the latter group increased only to a certain level, not reaching the critical level for cell firing. Decrease in external Cl concentration led to a shift of their reversal potential in depolarizing direction. Ionic mechanisms of depolarizing responses induced by glutamate in these groups of neurons are discussed.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology; D005724:Ganglia / Q000187:drug effects*; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D006372:Helix, Snails; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D002712:Chlorides; D005971:Glutamates; D018698:Glutamic Acid; D012964:Sodium; D011188:Potassium; D002118:Calcium
Ionnye mekhanizmy depoliarizatsionnykh otvetov, vyzyvaemykh applikatsieĭ glutamata, v nervnykh kletkakh vinogradnoĭ ulitki.