[Myoclonus induced by some benzodiazepines in the Papio papio. Comparison with myoclonus induced by intermittent light stimulation (author's transl)].
Papio papio may show two different kinds of myoclonus. A first type corresponds to myoclonus induced by photic stimulation (25 Hz). This type is always preceded by paroxysmal discharges. Another type of myoclonus may be induced, or at least facilitated, by some benzodiazepines, especially lorazepam and, to a lesser extent, diazepam. This type is neither preceded nor accompanied by paroxysmal discharges. A single injection of lorazepam (1 mg/kg i.v.) blocks the first type of myoclonus but favors the appearance of the second. However, these effects do not follow the same evolution; while myoclonus induced by photic stimulation disappears immediately after the injection, benzodiazepine-induced myoclonus appears only 10-15 min. Furthermore, whereas the former reappears after 150-210 min, the latter may persist for a longer time (up to 1 h). A preliminary pharmacologic study of benzodiazepine-induced myoclonus indicates that drugs increasing brain GABA level block this type of myoclonus. The possible reticular origin of benzodiazepine-induced myoclonus is suggested.
D000501:Allylglycine / Q000633:toxicity; D000818:Animals; D014151:Anti-Anxiety Agents; D001058:Apomorphine / Q000627:therapeutic use; D003975:Diazepam; D007980:Levodopa / Q000627:therapeutic use; D008140:Lorazepam; D009207:Myoclonus / Q000139:chemically induced* / Q000188:drug therapy / Q000209:etiology; D010215:Papio; D010775:Photic Stimulation / Q000009:adverse effects; D012701:Serotonin / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D000501:Allylglycine; D012701:Serotonin; D007980:Levodopa; D014635:Valproic Acid; D001058:Apomorphine; D008140:Lorazepam; D003975:Diazepam
Myoclonies induites par certaines benzodiazepines chez le Papio papio. Comparaison avec les myoclonies induites par la stimulation lumineuse intermittente.