Analysis of ts mutations of cold-adapted influenza A/Leningrad/134/57 virus variants.
By recombination of ts mutants of fowl plague virus belonging to different complementation groups with two cold-adapted variants of human influenza virus, the number and gene localization of ts mutations occurring in these variants was determined. In the course of passaging of human influenza virus at lowered temperature, the number of genes with ts mutations increased.
D003080:Cold Temperature; D005814:Genes, Viral; D005816:Genetic Complementation Test; D009980:Influenza A virus / Q000235:genetics*; D009154:Mutation; D011995:Recombination, Genetic