title: Serum lipoproteins and susceptibility of men of Indian descent to coronary heart disease. The St James Survey, Trinidad.
abstract: Prevalence of coronary heart disease (CHD) and fasting serum lipoprotein concentrations in ethnic groups in Port of Spain, Trinidad, were compared. In a total community survey of 1416 men aged 35-69 years, angina pectoris, a history of possible myocardial infarction, and major Q waves on the electrocardiogram were significantly more common in men of Indian descent than in other ethnic groups (relative risk about 3/1). Indians had significantly lower high-density-lipoprotein-cholesterol (HDLCh) concentrations and significantly higher low-density-lipoprotein-cholesterol (LDLCh) concentrations than other groups. After allowance for age and ethnic group, men with major Q waves or a history of possible myocardial infarction had a significantly greater ratio of LDLCh/HDLCh that men without either. Comparison of surveys in the Caribbean suggests that in this region CHD is prevalent only in communities in which a sizeable proportion of men have an LDHCh/HDLCh ratio greater than 6 and an LDLCh concentration above 5 mmol/l.
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology*; D004198:Disease Susceptibility; D004641:Emigration and Immigration; D006801:Humans; D007197:Indians, Central American; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012306:Risk; D014300:Trinidad and Tobago
chemical_list: D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL