Enzymes of pyrimidine deoxyribonucleotide metabolism in Mycoplasma mycoides subsp. mycoides.
Cell-free extracts of Mycoplasma mycoides subsp. mycoides were assayed for enzymes associated with the salvage synthesis of pyrimidine deoxyribonucleotides. They possessed kinases for deoxycytidine, (d)CMP, thymidine (deoxyuridine), dTMP, and nucleoside diphosphates; dCTPase and dUTPase; dCMP deaminase; thymidine (deoxyuridine) phosphorylase; and dUMP (dTMP) phosphatase. The existence of these enzymic activities together with ribonucleoside diphosphate reductase explains the capacity of cytidine to provide M. mycoides with deoxyribose for the synthesis of thymidine nucleotides from thymine.
D003844:DCMP Deaminase / Q000378:metabolism; D003842:Deoxycytidine Kinase / Q000378:metabolism; D009176:Mycoplasma mycoides / Q000201:enzymology*; D009701:Nucleoside-Diphosphate Kinase / Q000378:metabolism; D009703:Nucleoside-Phosphate Kinase / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011742:Pyrimidine Nucleotides / Q000378:metabolism*; D011755:Pyrophosphatases / Q000378:metabolism; D013937:Thymidine Kinase / Q000378:metabolism; D013939:Thymidine Phosphorylase / Q000378:metabolism
D011742:Pyrimidine Nucleotides; D013939:Thymidine Phosphorylase; D013937:Thymidine Kinase; D003842:Deoxycytidine Kinase; C019979:cytidylate kinase; D009703:Nucleoside-Phosphate Kinase; D009701:Nucleoside-Diphosphate Kinase; C020093:dTMP kinase; D010744:Phosphoric Monoester Hydrolases; D003844:DCMP Deaminase; D011755:Pyrophosphatases; C020007:dCTP pyrophosphatase; C020020:dUTP pyrophosphatase