A physiologically active kainic acid-preferring receptor in chicken retina.
Neurotoxicity induced by intravitreal injections of kainic acid in the chicken retina was effectively antagonized by piperidine 2,3-dicarboxylic acid and to a lesser extent D-gamma-glutamylglycine. 2-Amino-5-phosphonovaleric acid and glutamic acid diethyl ester were much less effective antagonists. These effects probably result from interactions with a kainic acid-preferring receptor localized on the OFF-centre bipolar cells. Piperidine 2,3-dicarboxylic acid and D-gamma-glutamylglycine also blocked selectively the OFF-responses of ganglion cells while glutamic acid diethyl ester was without effect. 2-Amino-5-phosphonovaleric acid rapidly blocked ON and, much more slowly, OFF-responses. These results are consistent with a role for kainic acid-preferring receptors located on the OFF-centre bipolar cells in chicken retina in physiological transmission between photoreceptors and the OFF-centre bipolar cells.
D015763:2-Amino-5-phosphonovalerate; D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D004151:Dipeptides / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D010786:Photoreceptor Cells / Q000502:physiology; D010875:Pipecolic Acids / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018092:Kainic Acid Receptors; D012160:Retina / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
D015763:2-Amino-5-phosphonovalerate; D000613:Aminobutyrates; D004151:Dipeptides; D007608:Kainic Acid; D010875:Pipecolic Acids; D011956:Receptors, Cell Surface; D018092:Kainic Acid Receptors; D014633:Valine; C028929:gamma-glutamylglycine; C029262:2,3-piperidinedicarboxylic acid; C012729:2-amino-4-phosphonobutyric acid