The activity of lysyl oxidase in experimental hepatic fibrosis.
Hepatic collagen synthesis was studied during progressive fibrosis induced by carbon tetrachloride in male Sprague-Dawley rats by determination of lysyl oxidase activity, hydroxyproline levels and morphological assessment. The activity of lysyl oxidase was increased significantly when fibrosis became apparent histologically.
D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D003094:Collagen / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D003094:Collagen; D000594:Amino Acid Oxidoreductases; D008249:Protein-Lysine 6-Oxidase; D006909:Hydroxyproline