title: Specificity of fibronectin--fibrin cross-linking.
abstract: Our experiments indicate that (1) non-covalent binding of fibronectin to fibrin is mediated by sites in a 27 kd NH2-terminal region and a 31 kd COOH-terminal region of fibronectin; (2) the 31 kd region is probably present in both chains of the fibronectin dimer; and (3) covalent (factor XIIIa-mediated) cross-linking of fibronectin and fibrin is between a glutaminyl residue in the 27 kd region of fibronectin and a lysyl residue in the COOH-terminal two-thirds of the fibrin alpha chain.
mesh_terms: D000595:Amino Acid Sequence; D002846:Chromatography, Affinity; D005176:Factor XIII / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D013379:Substrate Specificity; D013997:Time Factors; D011503:Transglutaminases; D014357:Trypsin / Q000378:metabolism
chemical_list: D005353:Fibronectins; D005337:Fibrin; D005176:Factor XIII; D011503:Transglutaminases; D014357:Trypsin