Alpha-receptor mediated inhibition of A2 noradrenergic neurons.
A series of adrenergic agonists and antagonists was applied by iontophoresis in the vicinity of noradrenergic neurons in the nucleus commissuralis of the rat. Alpha-2 receptor-mediated inhibition of these neurons was observed with single-unit recording techniques. The excitatory effects of the alpha-2 receptor antagonist piperoxane provided evidence that these receptors are of functional significance in vivo.
D000818:Animals; D004553:Electric Conductivity; D004837:Epinephrine / Q000494:pharmacology*; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D010880:Piperidines / Q000494:pharmacology*; D010883:Piperoxan / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D013015:Sotalol / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005971:Glutamates; D010880:Piperidines; D011942:Receptors, Adrenergic, alpha; D012701:Serotonin; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D010883:Piperoxan; D013015:Sotalol; D009638:Norepinephrine; D004837:Epinephrine