In vitro activity of ticarcillin plus clavulanic acid against bacteria isolated in three centers.
Over 10,000 bacterial isolates were tested against ticarcillin alone or combined with clavulanic acid (2.0 micrograms/ml). Of 5,295 Enterobacteriaceae, 72% were susceptible to ticarcillin alone, whereas 91% were susceptible to the combination. Bacteroides fragilis and Bacteroides melaninogenicus isolates were more susceptible to the combination. The activity of ticarcillin against other microorganisms was not profoundly influenced.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004338:Drug Combinations; D004755:Enterobacteriaceae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D001443:Prevotella melaninogenica / Q000187:drug effects; D013982:Ticarcillin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004338:Drug Combinations; D010406:Penicillins; D019818:Clavulanic Acid; D013982:Ticarcillin