[Relationship between arsenic-induced hypothermia and brain monoamines. (2). The roles of noradrenaline and dopamine].
It has been reported that hypothermia induced by intravenous administration of As2O3 3 mg/kg in rabbits is due to a decrease of noradrenaline (NA) in the hypothalamus. In this paper, the role of NA or dopamine (DA) on As2O3-induced hypothermia in rabbits were investigated. As2O3-induced hypothermia was not inhibited by pretreatment with FLA-63, a potent dopamine-beta-hydroxylase inhibitor, which produces an increase of DA and a decrease of NA in rabbit brain; and it was also inhibited by pretreatment with haloperidol or pimozide, potent DA-receptor blocking agents. On the contrary, pretreatment with phenoxybenzamine or dibenamine, alpha-receptor blocking agents, completely inhibited these hypothermia. These findings indicated that NA took an important part in thermoregulation in rabbits and certified that DA or DA-receptors were not involved As2O3-induced hypothermia.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001151:Arsenic / Q000494:pharmacology*; D000077237:Arsenic Trioxide; D001152:Arsenicals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004299:Dopamine beta-Hydroxylase / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D010087:Oxides; D011817:Rabbits
D000317:Adrenergic alpha-Antagonists; D001152:Arsenicals; D010087:Oxides; D004299:Dopamine beta-Hydroxylase; D006220:Haloperidol; D001151:Arsenic; D000077237:Arsenic Trioxide; D004298:Dopamine; D009638:Norepinephrine