[Prostacyclin synthesis-stimulating plasma factor in different age groups].
The vascular synthesis of prostacyclin (PGI2), the most powerful endogenous inhibitor of platelet aggregation and vasodilator, plays a central role in prevention of vascular damages by uncontrolled platelet aggregation. PGI2 seems to be an important defense mechanism of vascular system against, among others, the development of atherosclerosis. The PGI2-production of blood vessels is stimulated and thereby decisively influenced by a plasma factor (PF). This PF participates in the pathogenesis of several diseases. This activity of PF is for instance increased in renal insufficiency, which explains partly the haemorrhagic diathesis occurring in this illness. On the other hand there seems to be a hereditary lack of PF in patients suffering from thrombotic-thrombocytopenic purpura or haemolytic-uraemic syndrome. The PF was estimated in 62 healthy subjects collected in 8 age groups by means of bioassays and RIA-determination of 6-oxo-PGF1 alpha, the stable PGI2-metabolite, in tissue cultures. No differences of PF in the different age groups could be demonstrated. These findings support the view, that the PF as an important regulator of vascular PGI2-synthesis is functioning absolutely normal in older age.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D001011:Aorta / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D011464:Epoprostenol / Q000096:biosynthesis*; D005263:Femoral Artery / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
D011453:Prostaglandins; D011464:Epoprostenol
Der die Prostazyklinsynthese stimulierende Plasmafaktor in verschiedenen Altersgruppen.