[Changes in ocular tone, pH, ascorbic acid and lactic acid concentration in the aqueous humor of rabbits treated with aceclidine].
The Authors state the results of their research on the modification of the aqueous humor caused by the instillation of the Clonidina to the concentrations of 0,I25% in a group of ten rabbits. The results of these studies illustrate the variations of pH, the ocular tone, the concentration of lactic and ascorbic acid. In all the rabbits examined Clonidina was instillated in the RE while in the LE distilled water was instillated for the control. For two hours from the beginning of the experiment, every IO minutes measurements of the ocular tone in both eyes were taken. At the end of the two hours a sample of aqueous humor was taken from the RE and LE; It was found that: I) The drugs produced a very quick and prolonged decrease of the ocular tone. 2) There are no significant variations in the pH or in the concentration of lactic acid. 3) There was a notable reduction of the concentration of ascorbic acid.
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis* / Q000187:drug effects; D001205:Ascorbic Acid / Q000032:analysis*; D005123:Eye / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000032:analysis*; D019344:Lactic Acid; D011812:Quinuclidines / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
D007773:Lactates; D011812:Quinuclidines; D019344:Lactic Acid; D001205:Ascorbic Acid
Modificazioni del tono oculare, del pH, della concentrazione di acido ascorbico e di acido lattico nell'umore acqueo di coniglio trattato con aceclidina.