Reduced tyrosine hydroxylase activity in nigrostriatal system of sinoaortic-denervated rats.
Tyrosine hydroxylase activity was measured in the caudate nucleus and substantia nigra (pars compacta) of sinoaortic-denervated (SAD) and sham-operated (SO) rats 3 days after operation. The SAD groups had approximately a 50%, statistically significant, reduction of enzyme activity in both regions and also a significant reduction of dopamine in caudate nucleus. These results suggest a probable link between cortico-somatomotor integration and neural input from arterial baroreceptor neural pathways.
D000818:Animals; D001011:Aorta / Q000294:innervation; D001794:Blood Pressure; D002346:Carotid Sinus / Q000294:innervation; D003342:Corpus Striatum / Q000201:enzymology*; D004298:Dopamine / Q000502:physiology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine