[Nootropic and anxiolytic properties of endogenous ligands of benzodiazepine receptors and their structural analogs].
Experiments on mice and rats were made to study the nootropic and anxiolytic properties of endogenous ligands of benzodiazepine receptors of nicotinamide and inosin and of their new structural analogs--NMF and AZN. They were shown to have overt antihypoxic and anxiolytic effects. NMF and AZN given in 10-fold lower doses than endogenous benzodiazepine ligands appeared more active than these compounds and almost similar to diazepam as regards the activity. The data obtained point to the possibility of a purposeful search for new efficacious psychotropic and nootropic substances in the series of compounds structurally related to endogenous ligand of benzodiazepine receptors.
D000647:Amnesia / Q000188:drug therapy*; D000648:Amnesia, Retrograde / Q000188:drug therapy*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy*; D001362:Avoidance Learning / Q000187:drug effects; D003220:Conflict, Psychological; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy*; D007288:Inosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008024:Ligands; D008297:Male; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A
D014151:Anti-Anxiety Agents; D008024:Ligands; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D009536:Niacinamide; D007288:Inosine
Nootropnye i anksioliticheskie svoĭstva éndogennykh ligandov benzdiazepinovykh retseptorov i ikh strukturnykh analogov.