Clinical and pharmacological actions of a bolus injection of suxamethonium: two phenomena of distinct duration.
Twenty-five healthy adult patients undergoing general anaesthesia for elective surgery were randomly allocated to five groups (n = 5) and their mechanical isometric adductor pollicis activity (twitch height (TH)), was monitored. The patients in groups I, II and III received suxamethonium 1 mg kg-1 followed by Org NC 45 40 micrograms kg-1 5 min (group I), 15 min (group II) or 30 min (group III) after complete recovery from muscle paralysis. The patients in groups IV and V received only Org NC 45 and 80 micrograms kg-1, respectively. Mean maximum TH depression (about 42% of initial value in group IV and 5% in group V) decreased to less than 4% in groups I, II and III regardless of the time interval between the injections of suxamethonium and Org NC 45. Mean duration to 90% recovery of Org NC 45-induced blockade was prolonged in patients in groups I, II and III when compared with the patients in group IV (28 min v. 12 min).
D000328:Adult; D000768:Anesthesia, General; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013390:Succinylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D013390:Succinylcholine; D010197:Pancuronium