[Analysis of the neurochemical mechanisms of the psychotropic action of tuftsin and its analogs].
A study was made of the central effects of tuftsin (Thr-Lys-Pro-Arg) and its analogs (Leu1-tuftsin, D-Arg4-tuftsin) on the dopamine-dependent behavior and tyrosine hydroxylase (TH) activity. It was shown that the absence of direct effect of tuftsin and Leu1-tuftsin on postsynaptic dopaminergic receptors, revealed in experimental rotational behavior, correlates with a decrease in TH activity in the rat hypothalamus and striatum. Depression of the rotational behavior and increased activity of TH under the effect of D-Arg4-tuftsin suggest that this analog can modulate postsynaptic dopaminergic receptors by the antagonism type.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007128:Immunoglobulin Fragments / Q000494:pharmacology*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012399:Rotation; D014405:Tuftsin / Q000031:analogs & derivatives / Q000494:pharmacology*
D007128:Immunoglobulin Fragments; D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs; D011954:Receptors, Dopamine; D014405:Tuftsin
Analiz neĭrokhimicheskikh mekhanizmov psikhotropnogo deĭstviia taftsina i ego analogov.