[Comparative analysis of the behavioral, neurochemical and autonomotropic effects of mebikar and diazepam].
It has been shown that the tranquilizers, diazepam (a 1,4-benzodiazepine derivative) and mebicar (a derivative of bicyclic bisureas) produce one-line inhibition of the production of the conditioned reflex of active avoidance in rats and of their "open-field" motor activity. Both the drugs change the balance of neuroactive amino acids in the animals' brain. However they produce different changes: diazepam increases the content of asparaginic and glutamic acids, while mebicar raises that of gamma-butyric acid. No interrelationship was found between psychotropic and vegetotropic effects of the tranquilizers.
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001341:Autonomic Nervous System / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D001736:Biureas / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003214:Conditioning, Classical / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D051381:Rats; D014149:Tranquilizing Agents / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D001736:Biureas; D005971:Glutamates; D014149:Tranquilizing Agents; C015979:mebikar; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D003975:Diazepam
Sravnitel'nyĭ analiz nekotorykh povedencheskikh, neĭrokhimicheskikh i vegetotropnykh éffektov mebikara i diazepama.