Comparison of antisecretory potency and duration of action of the H2-receptor antagonists AH 22216, cimetidine, ranitidine and SK & F 93479 in the dog.
The antisecretory potency and duration of action of the new histamine H2-receptor antagonist AH 22216 have been compared with those of cimetidine, ranitidine and SK & F 93479 against histamine-induced gastric acid secretion in the conscious Heidenhain pouch dog. Ranitidine was 4-6 times more potent than cimetidine, with a similar duration of action. SK & F 93479 was approximately twice as potent as ranitidine and had a slightly longer duration of action. AH 22216 was most potent of the four H2-antagonists, some 20-30 times more active than cimetidine, and had an extremely prolonged duration of action.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D004285:Dogs; D005663:Furans / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D011744:Pyrimidinones / Q000494:pharmacology*; D011899:Ranitidine; D013997:Time Factors; D014230:Triazoles
D005663:Furans; D006146:Guanidines; D006635:Histamine H2 Antagonists; D010880:Piperidines; D011744:Pyrimidinones; D014230:Triazoles; C033275:SK&F 93479; D002927:Cimetidine; D011899:Ranitidine; C038304:lamtidine