Zinc metabolism in testicular feminization and surgical cryptorchid testes in rats.
Rats with testicular feminization (Tfm) had been reported to have a testis specific zinc deficiency. In this report it is demonstrated that this organ specific zinc deficiency was not corrected by intraperitoneal zinc administration. Normal littermates on the other hand showed a positive testicular response to zinc administration. The increased testicular zinc level in control animals returned to normal 1 week after the zinc treatment probably due to the fast turnover of this element in the testis. Not only surgically induced cryptorchidism but also surgical cryptorchidism and epididymodeferentectomy (to simulate Tfm conditions in normal adult rats) caused a drastic reduction in testicular zinc level. Unlike in Tfm rats, however, the decrease in zinc content in operated animals was not accompanied by a corresponding decrease in alkaline phosphatase activity. Zinc concentration and alkaline phosphatase activity in plasma or other organs were not affected by the surgical procedure. The testicular copper content in the operated animals was higher than that of the unoperated controls.
D000469:Alkaline Phosphatase / Q000378:metabolism; D013734:Androgen-Insensitivity Syndrome / Q000378:metabolism*; D000818:Animals; D003300:Copper / Q000378:metabolism; D003456:Cryptorchidism / Q000378:metabolism*; D008297:Male; D051381:Rats; D013737:Testis / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
D003300:Copper; D000469:Alkaline Phosphatase; D015032:Zinc