[Pharmacoprophylaxis of an experimental neurogenic pancreatic injury].
Experimental neurogenous injury to the rabbit pancreas was used to show that mechanical traumatization of the pyloroduodenal region leads to a considerable decrease in the creatine phosphate content and to the rise in the level of lactic acid in the gland tissue. Pharmacological analysis of the changes obtained demonstrated the reflex nature of the injury under consideration. High doses of noradrenaline were also found to cause pronounced metabolic alterations in the pancreatic tissue.
D000818:Animals; D004386:Duodenum / Q000293:injuries; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000627:therapeutic use*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage; D010179:Pancreas / Q000187:drug effects / Q000293:injuries* / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D011433:Propranolol / Q000627:therapeutic use*; D011708:Pylorus / Q000293:injuries; D011817:Rabbits; D012018:Reflex / Q000502:physiology
D006584:Hexamethonium Compounds; D007773:Lactates; D010725:Phosphocreatine; D019344:Lactic Acid; D018738:Hexamethonium; D011433:Propranolol; D009638:Norepinephrine
Farmakoprofilaktika éksperimental'nogo neĭrogennogo povrezhdeniia podzheludochnoĭ zhelezy.