Clonidine decreases rat urine kallikrein excretion by alpha-adrenergic receptor stimulation.
In normal conscious female Sprague-Dawley rats, clonidine dose-dependently (10-300 micrograms/kg) decreased urine kallikrein excretion to approximately 40% of the control value. The effect of clonidine on urine enzyme excretion was inversely related to diuresis-natriuresis. Phenoxybenzamine (1 mg/kg) or phentolamine (10 mg/kg) antagonized the effect of clonidine on urine enzyme excretion. Consequently, rat urine kallikrein excretion might be reduced when alpha-adrenergic receptors are stimulated by clonidine.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D007610:Kallikreins / Q000652:urine*; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine
D000316:Adrenergic alpha-Agonists; D010643:Phenoxybenzamine; D012964:Sodium; D007610:Kallikreins; D003000:Clonidine; D010646:Phentolamine