Non-gastrin secretogogue in ulcerogenic tumors of the pancreas.
In 18 patients with hypersecretion of acid, severe ulcer diathesis, and pancreatic islet cell tumor or hyperplasia, 14 had hypergastrinemia and 4 had normal plasma gastrin concentration. The neoplasms contained several gut peptides beside gastrin. The immunoreactive gastrin in the tumor extracts measured less than 7 ng/g, less than the amount previously reported. The extracts of each patient's tumor also contained a secretogogue other than gastrin that stimulated gastric acid secretion in rats. In addition, the plasma extracts of 2 patients also contained a secretogogue that stimulated acid secretion. After surgical resection of a recurrent metastatic tumor in 1 patient, basal acid secretion decreased from 13.9 to less than 1 meq/h, and the bioactivity of the plasma disappeared. These observations suggest the existence of a secretogogue that appears to be a protein in the pancreatic tumors of some patients with severe ulcer diathesis and hypersecretion.
D000236:Adenoma / Q000378:metabolism; D007516:Adenoma, Islet Cell / Q000378:metabolism; D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D005455:Fluorescent Antibody Technique; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000097:blood / Q000150:complications / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology*; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts