[Antisecretory and mucosa-protecting drugs in the acute care of peptic ulcer. Review of action principles, healing rates and side effects of approved ulcer drugs and drugs under clinical trial].
Peptic ulcers can be treated successfully with antisecretory drugs and drugs which have a protective effect. Thanks to their good tolerance and a form of administration acceptable to patients, the H2-receptor antagonists have won a leading position amongst the other ulcer therapeutics. It remains to be seen whether the substituted benzimidazoles will develop into a serious competitor. Until now the clinical experiences with the prostaglandins in the treatment of ulcers are not very encouraging.
D000208:Acute Disease; D000535:Aluminum / Q000009:adverse effects / Q000627:therapeutic use; D000863:Antacids / Q000009:adverse effects / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001570:Benzodiazepinones / Q000009:adverse effects / Q000627:therapeutic use; D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D010890:Pirenzepine; D011899:Ranitidine / Q000009:adverse effects / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000188:drug therapy*; D013392:Sucralfate; D014945:Wound Healing / Q000187:drug effects
D000863:Antacids; D000897:Anti-Ulcer Agents; D001570:Benzodiazepinones; D006635:Histamine H2 Antagonists; D010890:Pirenzepine; D013392:Sucralfate; D002927:Cimetidine; D011899:Ranitidine; D000535:Aluminum
Antisekretorische und Schleimhautprotektive Pharmaka in der akutbehandlung des peptischen Ulkusleidens. Eine Ubersicht über Wirkungsprinzipien, Abheilungsraten und Nebenwirkungen eingeführter und noch in klinischer Erprobung befindlicher Ulkustherapeutika.