Convulsive attacks due to antidepressant drug overdoses: case reports and discussion.
Antidepressant drug overdoses have been reported to induce seizures, but the etiology of this phenomenon is still unclear. Recently we treated three patients who suffered from epileptic seizures after acute overdoses of three antidepressant drugs: (a) Dibenzepin HCl (Noveril), (b) Maprotiline HCl (Ludiomil), and (c) Clorimipramine (Anafranil). After a review of the pertinent literature, the possible role of antidepressant drugs in the genesis of epileptic seizures is discussed.
D000328:Adult; D000928:Antidepressive Agents / Q000506:poisoning*; D002540:Cerebral Cortex / Q000187:drug effects; D002997:Clomipramine / Q000506:poisoning; D003984:Dibenzazepines / Q000506:poisoning; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000139:chemically induced; D004827:Epilepsy / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000506:poisoning; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced*; D013406:Suicide, Attempted
D000928:Antidepressive Agents; D003984:Dibenzazepines; D008376:Maprotiline; D002997:Clomipramine