Mouse lymph node germinal centers contain a selected subset of T cells--the helper phenotype.
Cells staining for Lyt-1 are more frequent than cells staining for Lyt-2 in both primary follicles and the cuffs of secondary follicles; there is an even more striking predominance of cells bearing only Lyt-1 in germinal centers. In addition, there is an increase in the total percentage of cells bearing T cell antigens in germinal centers compared to primary follicles. These differences in phenotype and distribution of T cell populations indicate the T cells in B cell areas, and especially in germinal centers, are not randomly selected, but rather represent a specific subpopulation of T cells enriched for the helper phenotype (Lyt-1+2-), perhaps involved in the development and/or function of germinal centers.
D000818:Animals; D000950:Antigens, Ly / Q000145:classification / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002454:Cell Differentiation; D005260:Female; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010641:Phenotype; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D018800:Thy-1 Antigens
D000950:Antigens, Ly; D000954:Antigens, Surface; D000961:Antilymphocyte Serum; D008565:Membrane Proteins; D018800:Thy-1 Antigens