Enhancement of cortical Na+,K+-ATPase by increased oxygen tensions: evidence of a new controlling mechanism.
This study describes the preliminary isolation of substances from beef brain cortex which are required to produce an oxygen-induced enhancing effect on Na, K-ATPase. Evidence is presented that at least 3 fractions--a heat stable, low molecular weight proteinaceous substance, a cholesterol rich, membranous component, and an as yet unidentified substance--are required to produce oxygen enhancement of Na, K-ATPase activity. These findings have specific ramifications in neurocellular physiology, especially as related to seizures.
D000251:Adenosine Triphosphatases / Q000302:isolation & purification / Q000378:metabolism; D000332:Aerobiosis; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D002417:Cattle; D002540:Cerebral Cortex / Q000201:enzymology*; D007700:Kinetics; D010100:Oxygen; D000254:Sodium-Potassium-Exchanging ATPase / Q000302:isolation & purification / Q000378:metabolism*
D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D010100:Oxygen