Lack of cholinergic deficit in the neocortex in Pick's disease.
Choline acetyltransferase activity was decreased in the frontal cortex in Alzheimer's and Gerstmann-Straussler dementias but not in Pick's disease. Cortical somatostatin was only decreased in Alzheimer's dementia. Postsynaptic muscarinic binding sites appeared to be decreased in a subpopulation of Alzheimer's patients. Our data indicate that a loss of cholinergic innervation of the cortex is not common to all dementias.
D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003704:Dementia / Q000201:enzymology*; D005625:Frontal Lobe / Q000201:enzymology*; D006801:Humans; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism
D011976:Receptors, Muscarinic; D013004:Somatostatin; D011813:Quinuclidinyl Benzilate; D002795:Choline O-Acetyltransferase