title: Silica fragments from millet bran in mucosa surrounding oesophageal tumours in patients in northern China.
abstract: Millet bran is a component of the diet in the area of highest oesophageal cancer incidence in northern China. Millet bran was found to contain up to 20% by weight of silica; some of this silica occurs as friable sheets or sharply-pointed fibres. These types of silica in millet bran are the most likely source of an unusual contamination with fragments of silica found in the oesophageal mucosa surrounding tumours in patients in northern China. A group of mucosal samples analysed together contained over 5,000 particles/g (100 parts per million by weight), ten times as many as were found in tissue from normal controls taken at necropsy in London. The modal diameter was 10 microgram (1-70 microgram). The particles were in the body of the mucosa and were not simply a surface contaminant. Silica fragments and fibres of similar size originating from other plant species occur in the diet in the two other regions of greatest incidence of oesophageal cancer, the Transkei and Iran. If such fragments enter the mucosa, they must cause some degree of trauma, and they may also be able to stimulate proliferation by providing anchorage. These findings suggest the possibility that silica particles might be involved in the aetiology of oesophageal cancer.
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D002523:Edible Grain / Q000009:adverse effects* / Q000032:analysis; D004938:Esophageal Neoplasms / Q000032:analysis / Q000209:etiology*; D004947:Esophagus / Q000032:analysis; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008897:Panicum / Q000009:adverse effects* / Q000032:analysis; D010316:Particle Size; D012822:Silicon Dioxide / Q000009:adverse effects* / Q000032:analysis
chemical_list: D012822:Silicon Dioxide