[Blood pressure during isometric and dynamic exercise under long-term antihypertensive treatment with beta receptor blockaders and diuretics].
In 34 men with essential hypertension the increase in blood pressure during static and dynamic exercise, after long-term antihypertensive medication, was investigated in a randomized prospective study. The patients were randomized to either hydrochlorothiazide or to atenolol. The exercise tests were performed after a mean treatment duration of 14 months. At this time, the entering blood pressure was significantly and equally lowered from 163/108 to 148/96 mm Hg with a mean dose of 71 mg hydrochlorothiazide and from 164/108 to 147/91 mm Hg with a mean dose of 144 mg atenolol. The heart rate was significantly lower under beta-blocker therapy (62 min-1) than with diuretics (78 min-1). There were no significant differences in the systolic and diastolic blood pressure rise between the two therapy groups during static exercise with the hand grip (33% of the earlier determined individual maximum for 2 min duration) and with the squatting technique (for 2 min). During dynamic exercise on the bicycle ergometer (50-100 W) the increase in the systolic blood pressure was significantly lower between 70 and 100 W, with a range from 12 to 28 mm Hg, in the beta-blocker group than in the diuretic group. There were no differences in diastolic blood pressure between the two therapy groups. Rate-pressure product as a parameter for the myocardial oxygen consumption and heart rate were significant lower in the beta-blocker group as compared with the diuretic group, at rest and during both kinds of exercise and at all exercise steps.(ABSTRACT TRUNCATED AT 250 WORDS)
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D001262:Atenolol / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology*; D005080:Exercise Test; D006339:Heart Rate; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D005082:Physical Exertion; D011897:Random Allocation; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D004232:Diuretics; D006852:Hydrochlorothiazide; D001262:Atenolol
Blutdruckverhalten während isometrischer und dynamischer Belastung unter antihypertensiver Langzeittherapie mit Beta-Rezeptorenblockern und Diuretika.