Electrophysiologic evidence for involvement of acetylcholine as a neurotransmitter in the lateral vestibular nucleus.
Monosynaptic spike generation of lateral vestibular nucleus (LVN) neurons with vestibular nerve stimulation in cats was inhibited by microiontophoretic atropine and gamma-aminobutyric acid (GABA). Spontaneous firing of the LVN monosynaptic neuron was increased by iontophoretic acetylcholine and glutamate. Atropine inhibited acetylcholine-induced firing without affecting glutamate-induced firing, while GABA blocked spike generation produced by acetylcholine and glutamate. Acetylcholine probably plays a role in transmission from the vestibular nerve to the LVN monosynaptic neurons.
D000109:Acetylcholine / Q000502:physiology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D005971:Glutamates / Q000494:pharmacology; D009434:Neural Pathways; D018377:Neurotransmitter Agents; D014725:Vestibular Nerve / Q000502:physiology*; D014726:Vestibular Nuclei / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005971:Glutamates; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D001285:Atropine; D000109:Acetylcholine