Evidence for a neuroactive component in the toxic extract from Gonyaulax monilata.
1. A toxic extract has been isolated from the red-tide dinoflagellate Gonyaulax monilata by a phenol-water extraction. 2. The compound action potential in the desheathed frog sciatic nerve is irreversibly blocked by topical application of the extract in concentrations as low as 40 ppm (w/v) in frog Ringer solution. 3. The toxin liberated by this algae has the potential for causing the neurological symptoms exhibited by animals following the administration of the toxic extract.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004141:Dinoflagellida; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008387:Marine Toxins / Q000494:pharmacology*; D009186:Myelin Sheath / Q000502:physiology; D009498:Neurotoxins / Q000494:pharmacology*; D011894:Rana pipiens; D012584:Sciatic Nerve / Q000502:physiology
D008387:Marine Toxins; D009498:Neurotoxins