Influence of beta-adrenergic antagonism on the response of bovine neonatal lungs to intravenous histamine.
The effects of IV histamine infusion  and beta-adrenergic blockade on pulmonary function were studied in neonatal Holstein calves, beta-Adrenergic blockade with IV propranolol increased total pulmonary resistance, but was without effect on lung compliance, lung volumes, and gas exchange. beta-Adrenergic blockade enhanced the histamine-induced increase in total pulmonary resistance and the decrease in dynamic and quasistatic compliance, lung volumes, and arterial oxygen tension. These data indicate that beta-adrenergic receptors may be present in the large and small airways of cattle and they modulate the effects of bronchoconstrictor agents as in other species.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002417:Cattle / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects*; D008170:Lung Compliance / Q000187:drug effects; D008176:Lung Volume Measurements / Q000662:veterinary; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D006632:Histamine; D011433:Propranolol