title: Lack of effect of ranitidine on the disposition of lignocaine.
abstract: Cimetidine has been shown to alter the disposition of lignocaine and other drugs that are highly extracted by the liver. In a placebo controlled study ranitidine (150 mg twice daily) did not alter the elimination half-life, systemic clearance or distribution of lignocaine (mg/kg) in six healthy subjects. The interaction with cimetidine appears to be unrelated to histamine H2-receptor antagonism.
mesh_terms: D000328:Adult; D005260:Female; D005663:Furans / Q000494:pharmacology*; D006207:Half-Life; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008012:Lidocaine / Q000378:metabolism*; D008297:Male; D011899:Ranitidine
chemical_list: D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D008012:Lidocaine