[Catecholamine content in the myocardium of growing rats with alpha- and beta-adrenergic blockades].
Studies of the effect of a single intraperitoneal injection of the alpha-adrenoblockers, phentolamine and dibenamine (5 mg/kg) and the beta-adrenoblockers, anapriline and alpheprol (1 mg/kg) into rats aged 7, 30 days and 3-5 months have demonstrated that as regards the degree of the changes in noradrenaline and adrenaline levels, the 7-day-old animals are more susceptible to the alpha-adrenoblockers, while the 30-day-old ones to the drugs of both groups. A relationship has been noticed between the age, the grade of the development of the adrenergic apparatus of the heart, metabolism of this organ and the pharmacodynamics of the adrenoblockers.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004837:Epinephrine / Q000378:metabolism*; D006128:Growth / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D009638:Norepinephrine; D004837:Epinephrine
Soderzhanie katekholaminov v miokarde rastushchikh krys pri al'fa- i beta-adrenergicheskoĭ blokade.