title: Hypnotic action and residual effects of a single bedtime dose of temazepam.
abstract: The hypnotic action and residual effects of a single bedtime dose of 7-chloro-3-hydroxy-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)one (temazepam, Planum) were investigated in young, healthy adults. Two different doses of the drug (20 or 30 mg) or placebo were administered as soft-gelatin capsules 30 min before bedtime. Motor activity was recorded by a wrist-worn activity monitor. In comparison to placebo both doses of temazepam reduced night-time motor activity, an effect that was significant only for the first half of the night. After temazepam subjects rated their sleep as deeper and more quiet. A dose of 30 mg caused increased ratings of "grogginess" in the morning and at noon. There was no evidence for rebound insomnia in the 3 nights following drug intake. The results indicate that temazepam 20 mg in young adults has a reliable hypnotic effect without significant residual sequelae.
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013693:Temazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D013693:Temazepam