[Effect of changes in the lipids of mitochondrial membranes on the activity of Mg2+-dependent ATPase].
The results obtained permit to assume that irradiation causes dysfunction of the regulatory system that provides the interdependence between the antioxidative activity of lipids, their composition and the activity of membrane-bound enzymes. There is virtually no correlation between the changes in hydrolase activity of the enzyme and the quantity of phosphatidylethanolamine (PE) and cardiolipin (CL). During the first hours following irradiation the dependence between the changes in the synthetase activity of ATPase and the fluidity of the lipid component of the membrane is directly proportional (just as it is observed in normal conditions); the lesser the fluidity of the lipid component the higher the hydrolase activity of the enzyme.
D000251:Adenosine Triphosphatases / Q000528:radiation effects*; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D002308:Cardiolipins / Q000528:radiation effects; D007425:Intracellular Membranes / Q000201:enzymology / Q000528:radiation effects*; D008563:Membrane Lipids / Q000528:radiation effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008930:Mitochondria, Liver / Q000201:enzymology / Q000528:radiation effects*; D010714:Phosphatidylethanolamines / Q000528:radiation effects; D011485:Protein Binding / Q000528:radiation effects; D013997:Time Factors; D014783:Viscosity
D002308:Cardiolipins; D008563:Membrane Lipids; D010714:Phosphatidylethanolamines; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase
Vliianie izmeneniĭ v lipidakh membran mitokhondriĭ na aktivnost' Mg2+-zavisimoĭ ATFazy.