Effect of 7,12-dimethylbenz(a)anthracene on the integument of the hibernating and nonhibernating 13-lined ground squirrel.
1. DMBA, a chemical carcinogen, was topically applied to skin patches of hibernating and nonhibernating ground squirrels (Spermophilus tridecemlineatus). 2. Macroscopically, hyperpigmentation, hair loss and excessive skin sloughing were evident in all treated nonhibernator skin patches. 3. Histological sections of skin revealed hyperkeratosis, epidermal vesicles, acanthosis, an indistinct basal layer and increased vascularization in nonhibernators. 4. Skin patches on hibernators were unaffected by treatment showing hibernation confers protection from the pathological effects of DMBA.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D006605:Hibernation; D012589:Sciuridae / Q000033:anatomy & histology / Q000502:physiology*; D012867:Skin / Q000187:drug effects* / Q000648:ultrastructure
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene