Interaction of neuroleptic drugs with a synthetic calcium-binding peptide analog of site III of rabbit skeletal troponin C. Phenothiazine selective binding.
The effects of nine drugs on the CD spectra of a synthetic calcium binding analog of site III of rabbit skeletal troponin C, can generally be divided into 3 groups: (1) that consisting of haloperidol, benperidol, molindone and promethazine, had no effect on the CD spectrum or calcium sensitivity of the apopeptide; (2) that composed of structurally rigid thioxanthenes, induced CD-detectable structural change in the apopeptide but prevented Ca2+-induced structural change; (3) that consisting of chlorpromazine, trifluoperazine and fluphenazine, induced structural change in the peptide but had no effect on the Ca2+-induced structural change.
D000818:Animals; D014150:Antipsychotic Agents / Q000378:metabolism*; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D002417:Cattle; D002942:Circular Dichroism; D009124:Muscle Proteins / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D010640:Phenothiazines; D013329:Structure-Activity Relationship; D014336:Troponin / Q000378:metabolism*; D019209:Troponin C
D014150:Antipsychotic Agents; D002147:Calmodulin; D009124:Muscle Proteins; D010455:Peptides; D010640:Phenothiazines; D014336:Troponin; D019209:Troponin C; D002118:Calcium