Cell differentiation and L-ornithine decarboxylase activity in the small intestine of rats fed low and high protein diets.
L-Ornithine decarboxylase activity is higher in enterocytes from rats fed low protein rather than high protein diets. Intestinal cell proliferation rate is 50% higher in rats fed high protein than low protein diets. This is not consistent with a direct role of ornithine decarboxylase in intestinal proliferation. It is shown that ornithine decarboxylase is preferentially associated with differentiating villus cells in intestine from rats fed low protein diets.
D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects; D004044:Dietary Proteins / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D007700:Kinetics; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000503:physiopathology; D051381:Rats; D011503:Transglutaminases
D004044:Dietary Proteins; D000217:Acyltransferases; D011503:Transglutaminases; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase