title: Circulating beta-adrenoceptor blocking factors in asthma.
abstract: The hypothesis that a generalized defect in beta-adrenoceptor function characterized asthma and atopy has been proposed by Szentivanyi. Such a defect may be intrinsic to the beta-adrenoceptor mechanism or could be attributed to circulating factors which interfere with the binding of catecholamines to beta-adrenoceptors. This study shows that sera from a proportion of the asthmatic population studied contain beta-adrenoceptor blocking activity and that the degree of inhibition correlates with some of the clinical indices of asthma.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000097:blood*; D001249:Asthma / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D001665:Binding Sites; D004802:Eosinophilia / Q000209:etiology; D006801:Humans; D008168:Lung / Q000378:metabolism; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D013806:Theophylline / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000319:Adrenergic beta-Antagonists; C012357:hydroxybenzylpindolol; D010869:Pindolol; D013806:Theophylline