Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects; D001284:Atrophy; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D004298:Dopamine / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000134:cerebrospinal fluid*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D008875:Middle Aged; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D051381:Rats; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents; D010648:Phenylacetates; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine; D006719:Homovanillic Acid