Isolation of new lymphotropic retrovirus from two siblings with haemophilia B, one with AIDS.
A human T-lymphotropic retrovirus was isolated from cultured T lymphocytes from two siblings with haemophilia B. Patient 2 was healthy, but patient 1 had acquired immunodeficiency syndrome. The retrovirus differed from human T-cell leukaemia virus (HTLV) but it was similar to the lymphadenopathy-associated retrovirus (LAV) in its morphology and its major core protein (P25). Both patients had antibodies against LAV and patient 1's retrovirus, detected by an enzyme-linked immunosorbent assay or a radioimmunoprecipitation assay. Seroepidemiological data indicated the transmission of this retrovirus by plasma products.
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology / Q000635:transmission*; D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001779:Blood Coagulation Factors / Q000009:adverse effects; D002478:Cells, Cultured; D000090266:Chromobox Protein Homolog 5; D017977:Deltaretrovirus / Q000276:immunology / Q000302:isolation & purification*; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D002836:Hemophilia B / Q000235:genetics / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis; D050378:T-Lymphocytes, Regulatory / Q000032:analysis; D014764:Viral Proteins / Q000032:analysis
D000914:Antibodies, Viral; D000954:Antigens, Surface; D001779:Blood Coagulation Factors; C000715594:CBX5 protein, human; D014764:Viral Proteins; D000090266:Chromobox Protein Homolog 5; C025667:prothrombin complex concentrates