Ludwig's angina following dental extraction as a cause of necrotizing mediastinitis.
A fatal case of Ludwig's angina is reported in which penicillin was used as the sole antibiotic. Bacteroides melanogenicus resistant by virtue of production of Beta-lactamase was present. It is suggested that a combination of penicillin and an antibiotic effective against anaerobes such as metronidazole is the most appropriate initial chemotherapy pending confirmation from the bacteriology laboratory.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001442:Bacteroides Infections / Q000188:drug therapy / Q000209:etiology*; D004352:Drug Resistance, Microbial; D006801:Humans; D008158:Ludwig's Angina / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008480:Mediastinitis / Q000188:drug therapy / Q000209:etiology*; D010403:Penicillin Resistance; D001443:Prevotella melaninogenica; D014081:Tooth Extraction / Q000009:adverse effects*
D000900:Anti-Bacterial Agents