[Comparative study of the anticoagulant activity of sulfated polysaccharides from red marine algae].
Experiments in vitro and in vivo were made to study and compare anticoagulant activity and acute toxicity of a great number of sulfate polysaccharides isolated from red sea algae. Polysaccharides were identified, producing an appreciable anticoagulant effect similar to that of heparin. The heparin-like effect of polysaccharides from red sea algae depends on the structure of the carbohydrate chain and the degree of macromolecule sulfation.
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology* / Q000633:toxicity; D001777:Blood Coagulation / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006493:Heparin / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D000461:Rhodophyta; D013329:Structure-Activity Relationship
D000925:Anticoagulants; D011134:Polysaccharides; D006493:Heparin
Sravnitel'noe issledovanie antikoaguliantnoĭ aktivnosti sul'fatirovannykh polisakharidov krasnykh morskikh vodorosleĭ.