Inhibition of cholinergic response by taurine in frog isolated skeletal muscle.
Carbamylcholine-stimulated contractions of isolated frog gastrocnemius muscle were inhibited in a non-competitive fashion by 5-25 mM taurine. Taurine had no effect on the resting length of the muscle. Caffeine-induced contractures were unaffected by taurine which indicates that the sarcoplasmic reticulum is not an important site of action for taurine. A possible functional role for taurine in skeletal muscle is discussed.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002217:Carbachol / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D011896:Rana temporaria; D013654:Taurine / Q000494:pharmacology*
D010276:Parasympatholytics; D013654:Taurine; D002110:Caffeine; D002217:Carbachol