Morphometrical analysis of T- and B-cell compartments of spleens in Hodgkin's disease.
One possible explanation for the defective cellular immunity in Hodgkin's disease is an abnormal distribution of T lymphocytes. To study this possibility a morphometric analysis of T- and B-areas in non involved and involved spleens of patients with Hodgkin's disease was undertaken. We found that in involved spleens a significant reduction of the T dependent area could be demonstrated. We concluded that this reduction is caused by an abnormal distribution of T lymphocytes in the spleen and may partly explain the defects in cellular immunity. In addition, the absence of overlap between the T/B area ratios of involved and non-involved spleens suggests, that a prediction on involvement of spleen can be made by morphometrical analysis of a small, random taken non-involved area.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D009708:Nucleotidases / Q000032:analysis; D013154:Spleen / Q000473:pathology*; D013160:Splenic Neoplasms / Q000473:pathology; D013601:T-Lymphocytes
D009708:Nucleotidases