The pharmacokinetic profile of carbidopa in dogs.
A pharmacokinetic study of carbidopa in beagle dogs has been carried out after intravenous (4 mg kg-1) and oral (75 mg) administration. An open model of three compartments was the best approach for the pharmacokinetic profile of carbidopa administered intravenously. The estimated biological t1/2 was 5 h and the plasma clearance 0.0053 (litre kg-1) min-1. The oral absorption of carbidopa was almost complete and the absolute bioavailability (F) was 88%.
D000818:Animals; D002230:Carbidopa / Q000378:metabolism*; D004285:Dogs; D006207:Half-Life; D007700:Kinetics; D008297:Male; D008954:Models, Biological
D002230:Carbidopa