[Participation of trigger membrane mechanisms in the effect of cardiac glycosides on the heart].
Strophanthine (5 X 10(-7) - 1 X 10(-5) g/ml) applied to the epicardium of the right and left auricles of an isolated frog heart produced negative chronotropic and positive inotropic effects. Specific effects of strophanthine developed during complete blockade of alpha-, beta- and M-cholinoreceptors of the heart. Upon isolated blockade or stimulating of the receptors indicated, the effects of strophanthine were shown to be changed. Attempts are made to prove the existence in the auricles and ventricles of the heart of glycoside inhibitory and stimulating receptors that form the constellation system of reciprocal relationships, with the mediator receptors, with this system participating in the triggering mechanism of heart membranes.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002301:Cardiac Glycosides / Q000494:pharmacology*; D003864:Depression, Chemical; D004088:Dihydroergotoxine / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D011896:Rana temporaria; D011950:Receptors, Cholinergic / Q000187:drug effects; D013268:Stimulation, Chemical; D013328:Strophanthins / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D002301:Cardiac Glycosides; D011950:Receptors, Cholinergic; D013328:Strophanthins; D004088:Dihydroergotoxine; D001285:Atropine; D011433:Propranolol
Ob uchastii triggernykh membrannykh mekhanizmov v deĭstvii sredechnykh glikozidov na serdtse.