Effects of beta-adrenergic agents on the murine lymphocyte response to mitogen stimulation.
The presence of beta-adrenergic receptors on murine lymphocytes has recently been demonstrated (8). beta-adrenergic agonists and antagonists have been found to alter the murine lymphocyte's response to either Concanavalin A or Lipopolysaccharide B. The regulation of the response to Concanavalin A or Lipopolysaccharide B by these beta-adrenergic ligands is most effective if the beta-adrenergic ligand is added within one hour of the addition of mitogen and at concentrations greater than 1 x 10(-7) M. The possibility that adrenergic modulation of the lymphocyte response may be beta-receptor mediated is supported by the observation of competition between adrenergic agonists and antagonists.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D008934:Mitogens; D011943:Receptors, Adrenergic, beta