Homovanillic acid in caudate and pre-frontal cortex following neuroleptics.
Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex 3 h following a single dose of a variety of neuroleptics. Thioridazine, haloperidol, fluphenazine, and metoclopramide increased HVA levels in caudate more than in pre-frontal cortex; whereas sulpiride and clozapine produced greater increases in HVA in pre-frontal cortex. These results are consistent with the proposal that rat pre-frontal cortex is relatively deficient in dopamine autoreceptors.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000378:metabolism*; D006719:Homovanillic Acid / Q000096:biosynthesis*; D008297:Male; D010648:Phenylacetates / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D010648:Phenylacetates; D006719:Homovanillic Acid