Na+/K+ ATPase and cell growth: EGF modulates enzymatic activity in cultured fibroblasts.
The behaviour of Na+/K+ ATPase during cell growth has been studied. Enzymatic activity, which is slightly affected during normal growth, is strongly reduced if the cells are incubated with epidermal growth factor (EGF). Evidence indicates that there is a double mechanism of action of the hormone.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D017301:Ca(2+) Mg(2+)-ATPase; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005347:Fibroblasts; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D004815:Epidermal Growth Factor; D000242:Cyclic AMP; D011494:Protein Kinases; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase