Guanylate cyclase stimulation by nitro-compounds is dependent on free Ca2+.
The stimulatory effect of nitro-compounds on arterial and hepatic guanylate cyclase became significantly depressed at 0.2 microM and higher concentrations of free Ca2+. The basal enzyme activity proved to be Ca2+-independent.
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide) / Q000031:analogs & derivatives*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002339:Carotid Arteries / Q000201:enzymology*; D006160:Guanosine Triphosphate / Q000378:metabolism; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007548:Isosorbide Dinitrate / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D009574:Nitro Compounds / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D013552:Swine
D009574:Nitro Compounds; D009599:Nitroprusside; C036852:magnesium GTP; D019830:Adenosine-5'-(N-ethylcarboxamide); C037047:manganese GTP; C038683:2',3'-di-O-nitro-(5'-N-ethylcarboxamido)adenosine; D006160:Guanosine Triphosphate; D006162:Guanylate Cyclase; D007548:Isosorbide Dinitrate; D000241:Adenosine; D002118:Calcium