Possible effects of prostaglandin (PGE2) on hypothalamo-hypophyseal-gonadal axis in male rhesus monkeys (Macaca mulatta).
The effect of hypothalamo-hypophyseal-gonadal axis of prostaglandin E2 (PGE2) administered in a dose of 500 micrograms/kg body weight/day for 15 days to adult monkeys is reported. It altered the functional integrity of the testis and accessory sex organs as reflected by the changes in the estimations of the alkaline phosphatase, acid phosphatase, succinic dehydrogenase in the testis, sialic acids in caput and cauda epididymis, citric acid in the seminal vesicles, and fructose in the prostate and seminal vesicles. Histologically, PGE2 produced a marked decrease in the sperm count and an increase in the number of and size of exfoliated granulocytes was observed, which might have been due to the stimulatory effect of PGE2 on gonadotrophin release. The alterations induced in the electroencephalograph also suggest an involvement of hypothalamic mechanisms for gonadotrophin release, for which certain plausible explanations have been provided. The results suggest that the changes in reproductive parameters might be a consequence of endocrinological and functional disturbance induced by PGE2 and there is a strong likelihood of involvement of hypothalamo-pituitary integration in this complex.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D015232:Dinoprostone; D004569:Electroencephalography; D005632:Fructose / Q000032:analysis; D005837:Genitalia, Male / Q000187:drug effects; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008253:Macaca mulatta; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D013091:Spermatogenesis / Q000187:drug effects; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D011458:Prostaglandins E; D005632:Fructose; D013385:Succinate Dehydrogenase; D000469:Alkaline Phosphatase; D015232:Dinoprostone