Ca-antagonistic substance from soft coral of the genus Sarcophyton.
A 14-membered ring diterpenoid named cembrane, possessing Ca-antagonistic action on the isolated rabbit aorta, has been isolated from a soft coral of the genus Sarcophyton, and its structure established by X-ray and spectroscopic data.
D000818:Animals; D001011:Aorta / Q000502:physiology; D002118:Calcium / Q000037:antagonists & inhibitors*; D055598:Chemical Phenomena; D002621:Chemistry; D003063:Cnidaria / Q000032:analysis*; D004224:Diterpenes / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D011817:Rabbits; D014961:X-Ray Diffraction
D004224:Diterpenes; C037071:cembrane; D002118:Calcium