Persistence of the effects of benzodiazepines. Pharmacodynamic studies in man.
The dynamic correlates of the pharmacokinetic profiles of various benzodiazepines used as hypnotics are described using impairment of performance. In particular, rate of absorption and the nature of the distribution phase are discussed, and the way in which the pharmacokinetic profile relates to clinical use.
D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000378:metabolism*; D001569:Benzodiazepines; D004304:Dosage Forms; D006801:Humans; D006993:Hypnotics and Sedatives; D007408:Intestinal Absorption; D007700:Kinetics; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D014151:Anti-Anxiety Agents; D004304:Dosage Forms; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines