Fetal heart rate response to a controlled sound stimulus after propranolol administration to the mother.
The fetal heart rate response to a controlled sound stimulus was recorded in 36 pregnant women before and after a maternal peroral dose of either 80 mg propranolol, or placebo. The sound stimulation was repeated 60 minutes, 120 minutes and 180 minutes after the drug administration. The fetal heart rate response to sound was significantly depressed by this moderate dose of propranolol. The sound stimulation method is found to reflect sensitively the immediate influence of propranolol on the fetus.
D000161:Acoustic Stimulation; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D005260:Female; D005318:Fetal Heart / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D011247:Pregnancy; D011433:Propranolol / Q000494:pharmacology*; D013016:Sound
D000319:Adrenergic beta-Antagonists; D011433:Propranolol