title: Dynorphin-immunoreactive neurons in the autonomic nervous system.
abstract: The distribution of dynorphin-like immunoreactivity in the autonomic nervous system of the rat and guinea-pig was investigated using an antiserum raised against dynorphin-(1-17). Dynorphin-like immunoreactivity was observed in fiber networks in the prevertebral sympathetic ganglia, in fibers in the enteric plexa , circular muscle layer and a few in the lamina muscularis of the mucosa of the gastrointestinal tract. After colchicine treatment dynorphin-immunoreactive cell bodies were observed both in the myenteric and submucous ganglia of the gut. The paravertebral ganglia contained occasional dynorphin-positive fibers and a few immunoreactive small intensely fluorescent cells. The distribution of the dynorphin-like immunoreactivity was compared to the distribution of enkephalin-like immunoreactivity, and it was found that in some areas there were similarities in the distribution patterns, although in other areas there were clear differences, indicating a non-identity of these two systems.
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001341:Autonomic Nervous System / Q000378:metabolism*; D004064:Digestive System / Q000294:innervation; D004399:Dynorphins; D004723:Endorphins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D005728:Ganglia, Sympathetic / Q000378:metabolism; D006168:Guinea Pigs; D008297:Male; D009197:Myenteric Plexus / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004723:Endorphins; D010446:Peptide Fragments; D004399:Dynorphins