title: [Analysis of factors limiting the applications of binomial statistics in studies of mediator secretion at neuromuscular synapses].
abstract: Binomial parameters of transmitter secretion were calculated on the basis of synaptic potential analyses at frog sartorius muscle. In some synapses negative values of parameter of the p were found. These negative values often occurred at low concentrations of Ca2+ ions and small amplitude of miniature end plate potentials. The obtained data were interpreted in terms of a model which presupposes the heterogeneity of the quantum transmitter release at different sites. A computer imitation of transmitter secretion showed that the appearance of the negative p parameter values and erroneous n estimations in the experiment are related with the shape of the distribution of quantum transmitter release probability and the amplitude of miniature end plate potentials.
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000378:metabolism*; D009482:Neurophysiology / Q000379:methods*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D013223:Statistics as Topic / Q000379:methods*; D009435:Synaptic Transmission
chemical_list: D018377:Neurotransmitter Agents; D002118:Calcium
vernacular_title: Analiz faktorov, ogranichivaiushchikh primenenie binomial'noĭ statistiki dlia issledovaniia sekretsii mediatora v nervno-myshechnoĭ sinapse.