title: A diabetes insipidus-like syndrome in the intact Yucatan miniature boar following implantation of desoxycorticosterone-acetate (DOCA).
abstract: A syndrome of polydipsia and polyuria is described in the intact adult Yucatan miniature boar following implantation of silicone rubber strips impregnated with desoxycorticosterone-acetate (DOCA). Water intake was significantly greater than control 5 days post-DOCA. Urine output was significantly greater than control 7 days post-DOCA, and urine osmolality was significantly decreased 8 days post-DOCA. Serum potassium was significantly less than control 24 hr post-DOCA, and serum sodium was consistently and significantly greater than control by 1 week post-DOCA. As suggested in the dog, the increase in water turnover following DOCA administration in the pig is initiated by an increased thirst followed by an increase in urine output.
mesh_terms: D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D003919:Diabetes Insipidus / Q000139:chemically induced* / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects; D004326:Drinking; D004343:Drug Implants; D007700:Kinetics; D009994:Osmolar Concentration; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013552:Swine; D013556:Swine, Miniature / Q000502:physiology*; D014556:Urine
chemical_list: D004343:Drug Implants; D003900:Desoxycorticosterone; D012964:Sodium; D011188:Potassium