Failure of MIF-1 or naloxone to reverse ischemic-induced neurologic deficits in gerbils.
MIF-1 and naloxone exert similar actions in several situations. Since naloxone, at a dose of 1 mg/kg IP, has been reported to reverse the neurologic deficits of gerbils whose right common carotid artery had been occluded, MIF-1 was tested under the same conditions and the effects compared with naloxone. Doses of 0.1, 1.0, and 10.0 mg/kg IP of MIF-1 and naloxone did not significantly alter the signs of either moderate or severe neurologic deficits. Thus, the results of this study with gerbils do not add evidence for the use of these opiate antagonists in strokes.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005849:Gerbillinae; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009420:Nervous System / Q000187:drug effects*
D009292:Narcotic Antagonists; D009270:Naloxone; D009075:MSH Release-Inhibiting Hormone