Scopolamine-induced locomotor stimulation in mice: effect of diazepam and a benzodiazepine antagonist.
The benzodiazepine diazepam and the benzodiazepine antagonist Ro 15-1788 were tested alone or in combination for their influence on scopolamine-induced locomotor stimulation in mice. The benzodiazepine antagonist had no effect by itself, but prevented the enhancement of scopolamine-induced locomotor stimulation produced by diazepam.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors*; D001570:Benzodiazepinones / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D005442:Flumazenil; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D005442:Flumazenil; D012601:Scopolamine; D003975:Diazepam