title: Factors relating to the beta blocker withdrawal syndrome.
abstract: Clinical studies were performed with groups of patients with ischaemic heart disease, patients with hyperthyroidism, and normal subjects, to investigate the possibility of a beta blocker withdrawal syndrome, by measurments of heart rate under conditions of increased sympathetic drive provided by standing with vasodilatation or by Valsalva's manoeuvre. A rebound increase in heart rate to levels significantly higher than the control heart rate off treatment was observed 2-5 days after stopping one or more weeks' treatment with dl-propranolol (160 mg/day), atenolol (200 mg/day), acebutolol (400 mg/day) or oxprenolol (160 mg/day).
mesh_terms: D000070:Acebutolol / Q000009:adverse effects; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D001262:Atenolol / Q000009:adverse effects; D003327:Coronary Disease / Q000188:drug therapy; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D010096:Oxprenolol / Q000009:adverse effects; D011433:Propranolol / Q000009:adverse effects; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D014636:Valsalva Maneuver
chemical_list: D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D010096:Oxprenolol; D000070:Acebutolol; D011433:Propranolol