Cells resistant to cytotoxic drugs are recognized by monoclonal antibody.
A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons. This molecule may be the P-glycoprotein previously associated with a drug-resistance permeability barrier (Riordan JR, Ling V: J Biol Chem 254:12701-12705, 1979).
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D003078:Colchicine / Q000494:pharmacology; D006224:Cricetinae; D003630:Daunorubicin / Q000494:pharmacology; D004351:Drug Resistance; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D008565:Membrane Proteins / Q000276:immunology; D008970:Molecular Weight; D014747:Vinblastine / Q000494:pharmacology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D006023:Glycoproteins; D008565:Membrane Proteins; D014747:Vinblastine; D003078:Colchicine; D003630:Daunorubicin