Selective inhibition of adenosine triphosphatase from plasma membranes of cultured endothelial cells by calcium antagonists.
A study has been made of the inhibitory effect of various kinds of hypotensive agents on ATPase of cultured endothelial cells from bovine carotid artery stimulated with Ca2+. The ATPase activity was selectively inhibited by calcium antagonists including a new compound, 6-ethoxycarbonyl-5,7-dimethyl-1-[3-(4-phenethyl-1-piperazinyl)propyl]-3- (alpha, alpha, alpha-trifluoro-o-tolyl)-2,4(1H,3H)-quinazolinedione dihydrochloride, while not by other hypotensive agents.
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D002417:Cattle; D002462:Cell Membrane / Q000201:enzymology; D002478:Cells, Cultured; D004727:Endothelium / Q000201:enzymology*; D009543:Nifedipine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology
D002121:Calcium Channel Blockers; D011799:Quinazolines; C042606:SP 294; D011433:Propranolol; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D009543:Nifedipine