[Characteristics of the thermoregulatory reactions of mice and rats to mediator-active substances].
The effect of dopaminomimetics (apomorphine, piribedil, bromocriptine), cholinomimetics (oxotremorine, arecoline, pylocarpine), and neuroleptics (chlorpromazine, haloperidol, triperidol) on rectal temperature (Tr) and temperature of different parts of the skin has been investigated in albino mice and rats of either sex. In rats these drugs cause the decrease of Tr and significantly increase tail temperature (Tt), as well as the temperature of the fore- and hindpaws (Tfp and Thp correspondingly). In mice the drug-induced fall of Tr is more significant than in rats; however, only neuroleptics essentially increase Tfp and Thp, the increase in Tt being inconsistent and small. Cholinomimetics and usually dopaminomimetics decrease Tt. Cholinomimetics do not affect and dopaminomimetics cause only transient and small rise in Tfp and Thp. The data do not confirm the key role of enhanced heat dissipation through the skin as a mechanism of hypothermic effect of cholino- and dopaminomimetic drugs in mice under the room temperature. In contrast to mice, thermoregulatory skin reactions to drugs in rats are much more pronounced, and together with palmar and plantar surfaces of the paws the same role in thermoregulationss is played by the skin of the tail.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D010277:Parasympathomimetics / Q000494:pharmacology*; D051381:Rats; D012881:Skin Temperature / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*; D013821:Thermometers; D013997:Time Factors
D014150:Antipsychotic Agents; D010277:Parasympathomimetics; D013566:Sympathomimetics
Osobennosti termoreguliatornykh reaktsiĭ mysheĭ i krys na mediatorno-aktivnye veshchestva.