title: [Preclinical study of the safety of the new Soviet tranquilizer gindarin].
abstract: The Soviet plant tranquilizer gindarin (an isoquinoline series alkaloid I-tetrahydropalmatine) isolated from the tubers of Stephania glabra Miers was subjected to a preclinical study. As regards the toxicity measured during a single administration to the laboratory animals, gindarin may be classified with moderately toxic substances. Daily intragastric administration of gindarin to rats in doses of 20 and 60 mg/kg for 3 months is likely to give rise to the changes in functions of the CNS, liver and blood. In doses of 1--50 mg/kg gindarin does not exhibit any allergizing, mutagenic or teratogenic properties. Administration of the drug in doses of 1--50 mg/kg from the 1st to the 20th day of pregnancy has shown it to produce marked embryotoxic action. In view of this fact gindarin is contraindicated in pregnancy.
mesh_terms: D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D014150:Antipsychotic Agents / Q000633:toxicity*; D001600:Berberine Alkaloids / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
chemical_list: D000470:Alkaloids; D014150:Antipsychotic Agents; D001600:Berberine Alkaloids; C014215:tetrahydropalmatine
vernacular_title: Doklinicheskoe izuchenie bezvrednosti novogo otechestvennogo trankvilizatora gindarina.