U-43,465F: a triazolobenzodiazepine with pronounced antidepressant-like as well as anxiolytic activities in animals.
U-43,465F displays activity in a number of classical antidepressant assays in rodents. Mechanistically, it potentiates norepinephrine and blocks the uptake of this amine but not that of serotonin. It is not a monoamine oxidase inhibitor nor does it markedly enhance monamine release. In several behavioral assays based upon conditioned and non-conditioned behavioral suppression, U-43,465F displays anxiolytic properties. Thus this compound possesses both antidepressant-like and anxiolytic activities and may have a special utility in the treatment of depressive disorders.
D000525:Alprazolam / Q000031:analogs & derivatives*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001569:Benzodiazepines; D012701:Serotonin; C035971:U 43465F; D012110:Reserpine; D001058:Apomorphine; D009638:Norepinephrine; D000525:Alprazolam