title: [Endogenous inhibitors of specific benzodiazepine binding in the cerebral cortex of the bull].
abstract: Chromatography of an acidic extract from bovine brain cortex on a Sephadex G-10 column demonstrated 7 fractions capable of inhibiting specific binding of 3H-diazepam to brain cortex membranes. It was established by ultrafiltration that the molecular weights of the inhibitors were not higher than 5000 dalton. Scatchard analysis of 4 main fractions has revealed a type of inhibition similar to the competitive one. Activity of all the fractions remained unchanged after pronase treatment.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003975:Diazepam / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D011402:Pronase / Q000494:pharmacology; D014020:Tissue Extracts / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D014020:Tissue Extracts; D011402:Pronase; D003975:Diazepam
vernacular_title: Endogennye ingibitory spetsificheskogo sviazyvaniia benzodiazepinov v kore golovnogo mozga byka.