Effect of cocaine on rat brain enzymes.
Acute administration of cocaine (20 mg/kg, i.p.) stimulated activity of striatal tyrosine hydroxylase (TH) which reached its maximum level at 10 min and returned to normal between 20-40 min. However, tryptophan hydroxylase (TPH) activity in the pons-medulla was reduced to a minimum at 10 min after its injection and returned to normal between 20-40 min. Activity of monoamine oxidase (MAO) was significantly reduced at 10 min and increased MAO (Type A) at 20 min showing a biphasic effect of cocaine on this enzyme. Relation of the time-courses of cocaine effects on the activity of these enzymes and the levels of related neurotransmitters is discussed.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D003042:Cocaine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014365:Tryptophan Hydroxylase / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase; D003042:Cocaine