Renal blood-flow changes during renal nerve stimulation in rats treated with alpha-adrenergic and dopaminergic blockers.
1. Blood flow through the inner cortex and outer medulla of the rat kidney was measured by the hydrogen wash-out technique. 2. Renal nerve stimulation caused vasoconstriction in both cortex and medulla. This constriction was abolished or reduced by phenoxybenzamine (9 mumole/kg I.V.), phentolamine (100 n-mole/kg) or prazosin (1.5 mumole/kg). 3. After prazosin (6 mumole/kg I.V.), renal nerve stimulation caused small but significant renal cortical vasodilatation. This vasodilatation was reversed by sulpiride (0.7 mumole kg-1 min-1), but was unaffected by propranolol (10 mumole/kg) or atropine (4.3 mumole/kg). 4. These results indicate the existence of dopaminergic vasodilator nerves to the renal cortex of the rat.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D007668:Kidney / Q000294:innervation*; D007672:Kidney Cortex / Q000098:blood supply; D007679:Kidney Medulla / Q000098:blood supply; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects*; D013469:Sulpiride / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D011799:Quinazolines; D011954:Receptors, Dopamine; D013469:Sulpiride; D011224:Prazosin