Binding sites for L-glutamate in the central nervous system of the rat.
The regional distribution of 2-amino-4-phosphonobutyrate (APB)/chloride-insensitive L-[3H]glutamate binding sites in the rat central nervous system was compared with that of APB/chloride-sensitive and with sodium-dependent binding sites. The distribution of APB-sensitive and APB-insensitive sites was not correlated, but the latter was identical to that of the sodium-dependent sites. The pharmacological specificity of the APB-insensitive sites was not consistent with that of an N-methylaspartate-preferring receptor, and was also different from the specificity determined for the sodium-dependent sites. The APB-insensitive sites appear to be unrelated to any other previously described excitatory amino acid binding site.
D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D017470:Receptors, Glutamate; D013116:Spinal Cord / Q000378:metabolism*; D014018:Tissue Distribution
D000613:Aminobutyrates; D002712:Chlorides; D005971:Glutamates; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate; D018698:Glutamic Acid; C012729:2-amino-4-phosphonobutyric acid