Serum concentrations and enzyme induction in epileptic children treated with phenytoin and valproate.
In a group of 59 epileptic children treated with phenytoin (PHT) and valproate sodium (VPA), either alone or in combination, the following effects were studied: (1) the reciprocal effect on the serum levels of the two drugs, and (2) the enzyme-inducing effects of both drugs. VPA had no effect on PHT levels, but PHT significantly decreased VPA concentrations. PHT enhanced both gamma-glutamyltranspeptidase activity (gamma-GT) and D-glucaric acid excretion (GLA); these effects were potentiated by VPA. VPA alone did not affect gamma-GT, but significantly enhanced GLA.
D002648:Child; D004790:Enzyme Induction; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D006801:Humans; D010672:Phenytoin / Q000097:blood / Q000627:therapeutic use*; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use*; D005723:gamma-Glutamyltransferase / Q000097:blood*
D014635:Valproic Acid; D010672:Phenytoin; D005723:gamma-Glutamyltransferase