beta-Adrenergic receptor-mediated increases in mouse cerebellar cyclic GMP levels in vitro.
Noradrenaline produced a stereospecific and dose-related stimulation of cyclic GMP levels in incubated mouse cerebellar slices. The effect was mimicked by beta-agonists such as isoprenaline while the alpha-agonist phenylephrine was only weakly active. Experiments with selective beta 1- and beta 2-adrenoceptor agonists and antagonists, indicated that beta 2-receptors are the dominant class involved in the cyclic GMP response.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002531:Cerebellum / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D018377:Neurotransmitter Agents; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D006152:Cyclic GMP; D009638:Norepinephrine