Leukotriene B4, an inflammatory mediator in gout.
Leukotriene B4 (LTB4), a metabolite of arachidonic acid and a potent cytotaxin, is generated by human peripheral polymorphonuclear leucocytes (PMNs) exposed to monosodium urate crystals (MSU). The leukotriene is present in gouty effusions in concentrations significantly greater than those found in synovial fluid from patients with active rheumatoid arthritis or osteoarthritis. Further metabolism and biological deactivation of LTB4 by PMNs are partly inhibited by MSU. It is concluded that LTB4 is an important chemical mediator in an acute gouty attack.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002630:Chemotactic Factors / Q000502:physiology; D003460:Crystallization; D006073:Gout / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007975:Leukotriene B4 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
D002630:Chemotactic Factors; D007975:Leukotriene B4; D014527:Uric Acid