A kinetic scattering approach to the non-linear instabilities of rat brain tyrosine hydroxylase preparations at several levels of tetrahydrobiopterin cofactor demonstrates evolutionary behavior characteristic of global dynamical systems.
Statistical patterns from the time-dependent fluctuations in kinetic scattering of a complex rat brain tyrosine hydroxylating system reveal near periodic, quasi-periodic, and chaotic regimes that alternate in a non-linear manner across linear changes in tetrahydrobiopterin cofactor concentrations, a phenomenon characteristic of the initial condition- and parameter-sensitive evolutionary behavior of global dynamical systems.
D000818:Animals; D005075:Biological Evolution; D001708:Biopterins / Q000031:analogs & derivatives / Q000378:metabolism*; D003342:Corpus Striatum / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D008956:Models, Chemical; D011621:Pteridines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000201:enzymology*; D014443:Tyrosine / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D011621:Pteridines; D001708:Biopterins; D014443:Tyrosine; D014446:Tyrosine 3-Monooxygenase; C003402:sapropterin