[Changes in catecholamine metabolism in the brains of rabbits after treatment with anti-brain antibodies and lithium ions].
The authors studied the changes in the activity of tyrosine hydroxylase and dopamine-beta-hydroxylase (the principal enzymes controlling the synthesis of catecholamines) in the whole brain of rabbits on intracisternal injection of immunoglobulin G isolated from the blood of brain-sensitized dogs or from the serum of schizophrenic humans. Also the changes of the content of principal catecholamines (DOPA, noradrenaline, adrenaline) in the animals brain on intravenous injection of lithium chloride after preliminary treatment of the animals with anticerebral antibodies were studied. The changes of the activity of both enzymes in both series of the experiments appeared to be uniformly directed, the fact, that gives one grounds to regard the mechanisms underlying these disturbances as similar. A positive effect of lithium on the catecholamine metabolism in the rabbit CNS was observed. This makes is possible to recommend the model used in this study for examining the efficacy and mode of action of a number of psychotropic drugs.
D000818:Animals; D000906:Antibodies; D001921:Brain / Q000276:immunology* / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D002712:Chlorides / Q000494:pharmacology*; D004285:Dogs / Q000276:immunology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D011817:Rabbits; D012559:Schizophrenia / Q000276:immunology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D000906:Antibodies; D002395:Catecholamines; D002712:Chlorides; D008094:Lithium; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D018021:Lithium Chloride
Izmenenie obmena katekholaminov v mozgu krolikov pod vliianiem protivomozgovykh antitel i ionov litiia.