title: Hepatic microsomal O-de-ethylases in cod (Gadus morhua): their induction by Aroclor 1254 but not by Aroclor 1016.
abstract: 1. The characteristics of hepatic ethoxycoumarin and ethoxyresorufin O-de-ethylases in juvenile cod (Gadus morhua) from the North Sea are described. 2. Feeding Aroclor 1254 to juvenile cod to produce liver concentrations of approx 900 microgram X g-1 (wet wt) induced ethoxycoumarin O-de-ethylase approx 30-fold, but had no effect on ethoxyresorufin O-deethylase activity. 3. Feeding Aroclor 1016 to juvenile cod to produce liver concentrations of approx 300 micrograms X g-1 (wet wt.) did not induce ethoxycoumarin O-de-ethylase activity.
mesh_terms: D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D001140:Aroclors / Q000494:pharmacology*; D020111:Chlorodiphenyl (54% Chlorine); D019363:Cytochrome P-450 CYP1A1; D005399:Fishes; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology*; D010088:Oxidoreductases / Q000096:biosynthesis*; D010105:Oxygenases / Q000096:biosynthesis*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D001140:Aroclors; D020111:Chlorodiphenyl (54% Chlorine); C027386:Aroclor 1016; D011078:Polychlorinated Biphenyls; D010088:Oxidoreductases; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D019363:Cytochrome P-450 CYP1A1