Comparison of some pharmacological properties of 4-aminopyridine and 3,4-diaminopyridine in vivo.
4-Aminopyridine and 3,4-diaminopyridine have been compared with respect to their interactions with morphine in the mouse in vivo. In contrast to 4-aminopyridine, 3,4-diaminopyridine was capable of reducing morphine-induced respiratory rate depression in doses which did not produce signs of toxicity.
D015761:4-Aminopyridine; D000077770:Amifampridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003864:Depression, Chemical; D004347:Drug Interactions; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects
D000631:Aminopyridines; D000697:Central Nervous System Stimulants; D009020:Morphine; D015761:4-Aminopyridine; D000077770:Amifampridine