Inhibition of polyadenylation of mRNA by gonadotropin releasing hormone.
The mechanism of extra pituitary inhibitory action of gonadotropin releasing hormone (GnRH) was investigated. Simultaneous injection of GnRH caused dose dependent inhibition of dihydrotestosterone (DHT) induced poly(A) polymerase in the ventral prostate of rat. In addition injection of GnRH to DHT treated animals caused reduced incorporation of 3H-uridine into poly(A)+ mRNA. Since poly(A) segment is known to help in translation of mRNA, it is possible that the inhibitory effect of GnRH is due to the inhibition of polyadenylation of mRNA.
D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D011061:Poly A / Q000378:metabolism*; D011062:Polynucleotide Adenylyltransferase / Q000037:antagonists & inhibitors*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014529:Uridine / Q000378:metabolism
D012333:RNA, Messenger; D013196:Dihydrotestosterone; D011061:Poly A; D007987:Gonadotropin-Releasing Hormone; C010661:surfagon; D009713:Nucleotidyltransferases; D011062:Polynucleotide Adenylyltransferase; D014529:Uridine