title: Necrotizing arteritis and spinal subarachnoid hemorrhage in Sjögren syndrome.
abstract: A 37-year-old woman with primary Sjögren syndrome developed mixed cryoglobulinemia and systemic vasculitis. Subarachnoid hemorrhage occurred as a result of necrotizing anterior spinal arteritis. Although rarely seen in mixed cryoglobulinemia, central nervous system complications have recently been documented in Sjögren syndrome. The patient's serum contained antibodies to the Ro(SSA) cytoplasmic antigen, and these antibodies were concentrated in the cryoglobulin fraction. Anti-Ro(SSA) antibodies are associated with the occurrence of vasculitis in patients with Sjögren syndrome, which suggests that the spinal arteritis and subarachnoid hemorrhage in this patient may have been directly related to the underlying connective tissue disorder.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010488:Polyarteritis Nodosa / Q000150:complications*; D012859:Sjogren's Syndrome / Q000150:complications*; D013118:Spinal Cord Diseases / Q000209:etiology* / Q000473:pathology; D013345:Subarachnoid Hemorrhage / Q000209:etiology* / Q000473:pathology