Hyperthermic action of somatostatin-28.
An intracisternal injection of somatostatin-28 produced hyperthermia in rats at cold, thermoneutral, warm ambient temperatures. The hyperthermic response to somatostatin-28 was not prevented by pretreatment of rats with the following agents: alpha-methylparatyrosine, phenoxybenzamine, propranolol, sulpiride, atropine, methysergide or naloxone. Somatostatin-28 prevented hypothermia induced by bombesin and gamma-MSH when it was administered simultaneously, but it left the hyperthermic response to TRH intact. The results indicate that somatostatin-28 produces hyperthermia by elevating a "set point" or regulated level of temperature. Under the conditions tested, the hyperthermic response to somatostatin-28 does not appear to be dependent on muscarinic cholinergic, serotonergic, alpha- or beta-adrenergic, dopaminergic or endogenous opiate system.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D001839:Bombesin / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced*; D007035:Hypothermia / Q000517:prevention & control; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D011749:Pyrogens; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*; D053561:Somatostatin-28
D011749:Pyrogens; D013004:Somatostatin; D053561:Somatostatin-28; D009074:Melanocyte-Stimulating Hormones; D001839:Bombesin