Tyr-MIF-1 affects passive avoidance behavior but not motor activity in rats.
The effects of the brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) were tested with several behavioral tests after peripheral injection in rats. In a passive avoidance test, Tyr-MIF-1 (1 mg/kg SC) resulted in significantly faster entry into the second compartment of a two-chamber shuttle box than was found with MIF-1 or diluent. Tyr-MIF-1 also resulted in flinch and escape responses that occurred at reliably lower amperage than the control. No significant effects were obtained on measures of ambulation, rearing, or defecation. The results demonstrate that Tyr-MIF-1 can affect behavior and that this action can differ from that of the same dose of MIF-1.
D000818:Animals; D001143:Arousal / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects; D009075:MSH Release-Inhibiting Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
C036930:tyrosyl-prolyl-leucyl-glycinamide; D009075:MSH Release-Inhibiting Hormone