An efficient chronic conflict paradigm: lick suppression by incremental footshock.
A conflict paradigm was designed which uses water as the reinforcer and incremental footshock as the punishment. It is easy to initiate responding and to maintain stable baselines over long periods of time. This paradigm proved selective for clinically effective anxiolytic compounds while a number of psychotropic compounds, which have no clinical anxiolytic activity, were not effective.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D003220:Conflict, Psychological; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology; D014867:Water; D014868:Water Deprivation / Q000502:physiology
D014151:Anti-Anxiety Agents; D014867:Water