Dopamine receptor-mediated depression of spinal monosynaptic transmission.
The effects of the dopamine agonists apomorphine, lisuride and lergotrile were evaluated on cat spinal cord monosynaptic transmission by stimulating the dorsal root and recording the ventral root compound action potential. All 3 agonists decreased the area of the monosynaptic response. This effect was prevented by pretreatment with the dopamine antagonists haloperidol and metoclopramide, but not with the alpha-adrenergic antagonist phentolamine. These results suggest the existence of spinal cord dopamine receptors which can modulate motor output.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002415:Cats; D004873:Ergolines / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008090:Lisuride / Q000494:pharmacology*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D004873:Ergolines; D011954:Receptors, Dopamine; D008090:Lisuride; D006220:Haloperidol; D008787:Metoclopramide; D001058:Apomorphine; C031875:lergotrile; D010646:Phentolamine