[Na+, K+ -ATPase inactivation as a trigger coupling factor of mediator depolarization and secretion].
The paper deals with an analysis of ouabain-induced processes: a decrease in transmembrane potential of neurone, an increase in the intensity of passive Na+, K+ and Ca2+ transport, secretion of different mediators by nerve endings. A hypothesis on inactivation of Na+, K+-ATPase as a trigger coupling factor of depolarization and secretion of mediators (and hormones) is discussed. According to this hypothesis inhibition of the Na, K-pump "work" may induce an additional opening of ion-selective canals, cause Ca2+ outflow from synaptic mitochondria to synaptoplasm due to intracellular accumulation of Na+, promote penetration of Ca2+ into a cell through the Ca2+ and Na+ metabolism.
D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009411:Nerve Endings / Q000378:metabolism; D009431:Neural Conduction / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
D007473:Ion Channels; D018377:Neurotransmitter Agents; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase
Inaktivatsiia Na+, K+ -ATPazy kak triggernyĭ faktor sopriazheniia depoliarizatsii i sekretsii mediatorov.