Dietary protein intervention during the postdosing phase of aflatoxin B1-induced hepatic preneoplastic lesion development.
The effects of high and low dietary protein intervention on the growth and development of hepatic preneoplastic lesions were examined. Inbred male F344 rats fed a semipurified (AIN-76) 20% casein diet were given doses orally of aflatoxin B1 (10 doses, each 250 micrograms/kg). One week after the last dose, animals were fed diets containing either 5 or 20% casein. Animals fed a 5% casein diet throughout the 12-week postdosing period had a marked reduction in development of gamma-glutamyltransferase-positive foci. Animals fed a 20% casein diet throughout the same period had the highest response. Groups fed the 5% casein diet for half of the postdosing period and 20% for the other half had intermediate responses. The data show that the high response observed in animals fed a high-protein diet can be inhibited by the postinitiation intervention of a low-protein diet. Likewise, the low response observed in the animals fed a low-protein diet was increased by the introduction of a high-protein diet late in the experiment.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D001835:Body Weight; D002273:Carcinogens; D004044:Dietary Proteins / Q000494:pharmacology*; D004334:Drug Administration Schedule; D006651:Histocytochemistry; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009929:Organ Size; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000032:analysis
D000348:Aflatoxins; D002273:Carcinogens; D004044:Dietary Proteins; D016604:Aflatoxin B1; D005723:gamma-Glutamyltransferase