Rheology of pharmaceutical granulations.
The rheological transformations that take place when granulating fluid is added to pharmaceutical powders have been monitored by means of a laboratory scale (approx. 50 g amounts) torque rheometer. The three formulations studied, based on lactose, sulfadiazine, and benoxaprofen, had common characteristics in that each passed through a granulation peak of maximum torque. In the zone immediately before the peak the granules were growing, while after it the material had properties of a cohesive, viscoelastic mass. Therefore, the rheological state of the material under process is not specified by a single torque reading, but by the rheological history of the granulation.
D002626:Chemistry, Pharmaceutical; D007785:Lactose; D011208:Powders; D011422:Propionates; D012212:Rheology; D013411:Sulfadiazine; D013997:Time Factors
D011208:Powders; D011422:Propionates; D013411:Sulfadiazine; C011677:benoxaprofen; D007785:Lactose