Prenylamine and the myocardial response to ischaemia and reperfusion: effects of acute and chronic treatment.
The ability of prenylamine gluconate (Segontin) to influence the extent of myocardial ischaemic injury was investigated in the isolated 'working' rat heart preparation. The drug was administered either acutely alone (4 microM litre-1 in the perfusion medium) or chronically plus acutely in which case animals were pre-treated (10 mg kg-1 day-1 orally) for 10 days and the drug was then also added (4 microM litre-1) to the perfusate. Acute administration alone resulted in a small reduction in spontaneous functional performance in the aerobic isolated heart in comparison with gluconate treated controls. It also increased the percentage of hearts able to recover functional activity after a period of severe ischaemia and decreased ischaemia induced injury as assessed by enzyme leakage. In contrast to the acute results the combination of chronic and acute administration of prenylamine did not significantly alter spontaneous cardiac function. Although a small increase in the number of hearts that recovered function was apparent, there was a concomitant decrease in post-ischaemic functional performance with no reduction of ischaemia induced enzyme leakage.
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000201:enzymology; D011299:Prenylamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011299:Prenylamine