[Effect of phenazepam on the body organs and systems of rats subjected to prolonged ethanol exposure].
Experiments made on 80 randombred male rats have demonstrated that the tranquilizer phenazepam in a daily dose of 1 mg/kg administered per os to intact animals for 14 days produces no adverse changes in the hematological, biochemical and morphological indicators that characterize the status of the most important organs and systems of the body. Administration of phenazepam to rats preexposed to ethanol (4 g/kg per os once a day for a month) has been found to retard the elimination of morphological alterations in the liver and brain induced by ethanol. The results obtained allow recommending the use of appropriate experimental models in the preclinical study of the safety of new antialcoholic agents.
D000437:Alcoholism / Q000188:drug therapy*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000009:adverse effects*; D001769:Blood / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D051381:Rats; D013737:Testis / Q000187:drug effects; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
Vliianie fenazepama na sostoianie organov i sistem organizma krys, podvergnutykh dlitel'nomu vozdeĭstviiu étanola.