Do prostaglandins mediate the somatostatin preventive effect on gastric lesion?
The inhibition of endogenous prostaglandin synthesis by indomethacin treatment blocks the somatostatin preventive effect on the gastric lesions induced in a stress model and has no preventive effect on an intragastric distension model.
D000818:Animals; D016861:Cyclooxygenase Inhibitors; D004195:Disease Models, Animal; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000627:therapeutic use*; D013270:Stomach / Q000502:physiology; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D013004:Somatostatin; D007213:Indomethacin