title: The effect of D-alpha-aminoadipate on excitatory amino acid responses recorded intracellularly from motoneurones of the frog spinal cord.
abstract: The excitatory responses to amino acids were recorded intracellularly from motoneurones in the isolated frog spinal cord and the effect of the antagonist D-alpha-aminoadipate examined. An unusual profile of antagonism was obtained in that with 50-100 microM D-alpha-aminoadipate the depolarization to quisqualate was unaffected (or slightly potentiated) while those to L-glutamate, L-aspartate and N-methyl-D-aspartate were all considerably attenuated. D-alpha-aminoadipate did not influence passive membrane properties although a small hyperpolarization was sometimes evident. Dorsal root evoked excitations of motoneurones, particularly those using low strength stimulation, were also susceptible to antagonism by D-alpha-aminoadipate. These data suggest a separate neuroeffector/receptor mechanism for quisqualate compared to L-glutamate, L-aspartate and N-methyl-D-aspartate.
mesh_terms: D015074:2-Aminoadipic Acid / Q000494:pharmacology*; D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D000870:Anterior Horn Cells / Q000187:drug effects*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D005071:Evoked Potentials / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D066298:In Vitro Techniques; D009046:Motor Neurons / Q000187:drug effects*; D016202:N-Methylaspartate; D010069:Oxadiazoles / Q000037:antagonists & inhibitors; D016318:Quisqualic Acid; D011896:Rana temporaria; D013126:Spinal Nerve Roots / Q000502:physiology
chemical_list: D000596:Amino Acids; D000600:Amino Acids, Dicarboxylic; D018691:Excitatory Amino Acid Antagonists; D010069:Oxadiazoles; D015074:2-Aminoadipic Acid; D001224:Aspartic Acid; D018698:Glutamic Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid