A study of the hepatic microsomal monooxygenase of sea birds and its relationship to organochlorine pollutants.
1. The levels of hepatic microsomal monooxygenase in sea birds were determined using organochlorine substrates. Levels of cytochrome P450 and organochlorine residues were also measured. 2. The razorbill (Alca torda) and puffin (Fratercula arctica) showed highly variable activities which were resolved into multiple peaks on frequency diagrams. 3. The most active individuals amongst razorbills were early season females with large ovaries. 4. The properties of monooxygenase from individuals of low and high activity were compared. 5. The results are discussed in relation to PCB pollution.
D000818:Animals; D001717:Birds / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010088:Oxidoreductases / Q000378:metabolism*; D012621:Seasons; D013045:Species Specificity; D014873:Water Pollutants / Q000494:pharmacology*; D014874:Water Pollutants, Chemical / Q000494:pharmacology*
D006843:Hydrocarbons, Chlorinated; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases