[Effect of benzodiazepine and GABA derivatives on the energy metabolism indices in brain edema].
The development of toxic and traumatic brain edema in rats is accompanied by a decrease in the ATP level, in the total amount of adenyl nucleotides, the magnitude of the energy charge in the ATP-ADP-AMP system, and by an elevation in the content of AMP. Diazepam (0.5 mg/kg) and phenibut (50 mg/kg) that exert an antiedematous action reduce the amplitude of bioenergetic shifts during edema. As for piracetam (1000 mg/kg) it exhibits an insignificant effect. It is assumed that positive action of diazepam and phenibut on brain bioenergetics in edema is realized via the GABA-ergic system.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001929:Brain Edema / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D008297:Male; D051381:Rats; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid
Vliianie proizvodnykh benzdiazepina i GAMK na nekotorye pokazateli énergeticheskogo obmena pri oteke golovnogo mozga.