The combined effect of DDT and polychlorinated biphenyls on the blood and heart rate of the white leghorn cockerel (Gallus domesticus).
1. The joint action of DDT and PCB (Aroclor 1254) on blood parameters and heart rate was studied in the White Leghorn cockerel (Gallus domesticus). 2. PCB alone or combined with DDT reduced heart rate, this change being non-permanent since it returned to normal values when the contaminated diet was replaced by normal diet. 3. PCB alone or combined with DDT had a detrimental effect on packed cell volume, hemoglobin concentration and total erythrocyte count. Hemoglobin concentrations from the experimental group remained lower than control values after removal of the contaminated diet. 4. An antagonistic action rather than a synergistic or additive effect in blood parameter was observed in birds after being exposed to PCB-DDT mixture.
D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002645:Chickens; D020111:Chlorodiphenyl (54% Chlorine); D003634:DDT / Q000494:pharmacology*; D004032:Diet; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects*; D006454:Hemoglobins / Q000032:analysis; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*
D001140:Aroclors; D006454:Hemoglobins; D020111:Chlorodiphenyl (54% Chlorine); D003634:DDT; D011078:Polychlorinated Biphenyls