title: Alpine skiing and acute beta-blockade.
abstract: The effect of acute unselective (propranolol) and beta 1-selective (atenolol) beta-adrenoceptor blockade was studied on alpine skiing in six leisure and seven elite skiers. Prior to the skiing tests a short time "all out" cycle ergometer test (Wingate muscle power test) was performed to confirm whether a beta-blocking effect (80 mg propranolol and 100 mg atenolol orally) was present or not. Peak and average power of the Wingate test showed an impairment in the order of 4%--6% (P less than 0.05--0.001). Peak blood lactate was only reduced after propranolol (0.05 greater than P greater than 0.01). During leisure skiing under submaximal exercise conditions peak blood lactate was increased (P less than 0.05) as compared to placebo, but rated perceived exertion (RPE) was unchanged as well as the estimated skiing technique. The elite skiers showed prolonged performance times (P less than 0.05) after beta-blockade and in the case of propranolol also reduced peak and mean blood lactates (P less than 0.05). It is suggested that during intense exercise propranolol reduced lactate formation, which is in line with previous reports. This might impair short time, "explosive" type muscular exercise. If there is a risk factor for injury during beta-blockade and alpine skiing, it might be connected to the impaired performance and metabolism in relation to intense exercise and propranolol treatment.
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001262:Atenolol; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007773:Lactates / Q000494:pharmacology; D008875:Middle Aged; D010807:Physical Endurance; D005082:Physical Exertion; D011433:Propranolol / Q000494:pharmacology; D012865:Skiing; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D007773:Lactates; D001262:Atenolol; D011433:Propranolol