Respiratory syncytial virus infection in Syrian hamsters. II. Regulation of the immune response.
The dynamics of immune cell responsiveness in the process of development of primary and secondary immune responses after infection of adult Syrian hamsters with native respiratory syncytial virus (RSV) was studied. In primary immune response, the enhancement of functional responsiveness of lymphocytes to mitogens and the maximum level of their spontaneous proliferative activity were found to precede the optimal level of antibody synthesis. Regulation of the dynamics of immunogenesis after reinfection of animals showed typical features of the secondary immune response.
D000818:Animals; D000917:Antibody Formation; D006224:Cricetinae; D007109:Immunity; D008213:Lymphocyte Activation; D008647:Mesocricetus; D012136:Respiratory Syncytial Viruses; D010253:Respirovirus Infections / Q000276:immunology*; D013154:Spleen / Q000276:immunology