A comparative double-blind study of loprazolam, 1 mg and 2 mg, versus placebo in anxiety-induced insomnia.
A double-blind trial was carried out in 40 anxious in-patients with insomnia to compare the hypnotic effectiveness and tolerance of loprazolam, 1 mg and 2 mg, versus placebo. Groups of 10 patients received one or other dose of loprazolam or placebo for 7 nights and then placebo for the following 3 nights. Sleep quality and morning residual effects were assessed each morning during the 10-day trial period by means of a sleep questionnaire. The results showed that 1 mg loprazolam was superior to placebo but less effective than 2 mg loprazolam. No side-effects were reported at either dose level.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001008:Anxiety Disorders / Q000150:complications*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011897:Random Allocation; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000209:etiology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D010919:Placebos; D001569:Benzodiazepines; C020168:triazulenone