Serologic relatedness between Thy-1.2 and actin revealed by monoclonal antibody.
Monoclonal antibodies with affinity for Thy-1.2 on thymocytes also can bind to actin within marsupial, murine, and human cells. A similar cross-reactivity between Thy-1.1 and vimentin was revealed by Dulbecco and co-workers employing monoclonals. A computer-assisted analysis of the amino acid composition provided suggestive evidence for the occurrence of sequence homology between Thy-1.1 or Thy-1.2, actin, and vimentin that likely accounts for the serologic relatedness detected by hybridoma antibodies.
D000199:Actins / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D001666:Binding Sites, Antibody; D003429:Cross Reactions; D003599:Cytoskeleton / Q000276:immunology; D006801:Humans; D007152:Immunologic Capping; D007381:Intermediate Filament Proteins / Q000276:immunology; D007614:Macropodidae; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure; D018800:Thy-1 Antigens; D014746:Vimentin
D000199:Actins; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007381:Intermediate Filament Proteins; D018800:Thy-1 Antigens; D014746:Vimentin