Synthesis and CNS activities of some 2-alkyl-3(2-substituted indol-3-yl)-methyl, 6-substituted-quinazolin-4(3H)-ones.
Nineteen title compounds (1-3, Fig. 1) have been synthesised by Mannich reaction of the corresponding 2,6-disubstituted-quinazolones, 2-substituted-indole and formaldehyde. Some of them have been found to be CNS stimulants while some others were CNS depressants. Compounds 2c and 2d have been found to possess good anticonvulsant activity in MES protection test at the dose level of 100 mg/kg.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000138:chemical synthesis; D000697:Central Nervous System Stimulants / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D051379:Mice; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D012110:Reserpine / Q000037:antagonists & inhibitors; D014203:Tremorine / Q000037:antagonists & inhibitors
D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D000697:Central Nervous System Stimulants; D011799:Quinazolines; D012110:Reserpine; D014203:Tremorine