Induction of action potentials in frog slow muscle fibres paralysed by alpha -bungarotoxin.
Slow muscle fibres in the frog are normally incapable of generating action potentials. However, several days after an intramuscular injection of alpha - bungarotoxin, they acquire the ability to generate action potentials. It appears that alpha -bungarotoxin induces the action potential mechanism in slow fibres because it blocks acetylcholine receptors, and thus interferes with the action of non-quantal acetylcholine leaking from nerve terminals, or because the toxin has some other, as yet undefined, action on nerve or muscle.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology*; D004558:Electric Stimulation; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects; D011896:Rana temporaria; D011950:Receptors, Cholinergic / Q000187:drug effects
D002038:Bungarotoxins; D011950:Receptors, Cholinergic