Uterine responsiveness of oxytocin and prostaglandin F2 alpha in heat-acclimated rats.
1. Contractility, in vitro, was examined in uterine horns of rats acclimated to 35 degrees C and controls (22 degrees C). 2. Responses to oxytocin and prostaglandin F2 alpha were measured in the four stages of the estrus cycle and on day 4 of pregnancy. 3. Responses to oxytocin of uteri from heat acclimated rats were significantly depressed in estrus, metestrus and diestrus, while responses to prostaglandin F2 alpha were decreased in estrus and metestrus. 4. Responses to oxytocin and prostaglandin were slightly but insignificantly decreased in uteri from pregnant day 4 heat-acclimated rats.
D000064:Acclimatization; D000818:Animals; D015237:Dinoprost; D004971:Estrus; D005260:Female; D006358:Hot Temperature; D010121:Oxytocin / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D011460:Prostaglandins F; D011374:Progesterone; D010121:Oxytocin; D015237:Dinoprost