Cholinergic manipulation of perioral behaviour induced by chronic neuroleptic administration to rats.
Rats treated continuously for 4 months with haloperidol (1.4-1.6 mg/kg/day), trifluoperazine (4.5-5.1 mg/kg/day), or sulpiride (102-110 mg/kg/day), but not clozapine (23-26 mg/kg/day), exhibited an increased frequency of chewing jaw movements. Chewing in both control and haloperidol-treated rats was increased by acute administration of the cholinergic agents pilocarpine or physostigmine. Physostigmine or pilocarpine also induced abnormal gaping jaw movements; physostigmine-induced gaping was more prevalent in haloperidol-treated rats than control rats receiving physostigmine alone. Acute administration of the anticholinergic agents scopolamine and atropine decreased chewing in control animals and reduced haloperidol-induced chewing to control values or below. The effects of these cholinergic manipulations suggest that neuroleptic-induced perioral responses in rats do not resemble tardive dyskinesia in man.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D005145:Face; D008297:Male; D009055:Mouth; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010276:Parasympatholytics / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D010276:Parasympatholytics; D010277:Parasympathomimetics