Neuroactive amino acids influence gonadotrophin output by a suprapituitary mechanism in either rodents or primates.
Systemic administration of excitatory amino acids (Glu or NMA) rapidly enhances LH release (rodents or primates) and GABA blocks this action (rodents). In the present study rodent and primate pituitaries were incubated with NMA, Glu and/or GABA, with or without added LH-RH. Only LH-RH affected LH release. Therefore the probable site of NMA, Glu or GABA action on LH release in both rodents and primates is suprapituitary.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000378:metabolism*; D008252:Macaca fascicularis; D008254:Macaca nemestrina; D008297:Male; D016202:N-Methylaspartate; D010215:Papio; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000596:Amino Acids; D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D016202:N-Methylaspartate; D007986:Luteinizing Hormone