Pregnancy and cystinuria.
46 pregnancies in patients with cystinuria treated with a high fluid intake alone or in combination with D-penicillamine resulted in 41 normal births. New stones formed in 18 pregnancies, with stone passage early in 4 of them. No patient required stone removal during pregnancy. Other pregnancy-related problems included hypertension and urinary-tract infection, which responded to conventional management. Assiduous maintenance of a sustained high fluid intake is even more important than usual during pregnancy and the puerperium. D-penicillamine appears relatively safe for severe cases, although most patients can be managed without it. With careful medical management stone-forming cystinurics can be safely conducted through pregnancy without increased risks to the mother or fetus.
D001724:Birth Weight; D003555:Cystinuria / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005817:Genetic Counseling; D006801:Humans; D010396:Penicillamine / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D012306:Risk; D014545:Urinary Calculi / Q000150:complications / Q000517:prevention & control / Q000601:surgery
D010396:Penicillamine