Effect of egg yolk phospholipids plasma elimination and tissue distribution of coenzyme Q10 administered in an emulsion to rats.
When coenzyme Q10 (CoQ10) in fat emulsion emulsified with egg yolk phospholipids (PL) was administered intravenously to rats, CoQ10 was eliminated more rapidly than when it was solubilized with a polyoxyethylene derivative of hydrogenated castor oil. Although CoQ10 in emulsion form is distributed mainly to liver, increase of PL concentration in the emulsion increased the distribution of CoQ10 to heart which is a target organ for CoQ10.
D000818:Animals; D003067:Coenzymes; D004530:Egg Yolk; D004655:Emulsions; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D010743:Phospholipids / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism
D003067:Coenzymes; D004655:Emulsions; D010743:Phospholipids; D014451:Ubiquinone; C024989:coenzyme Q10