Origin and significance of intranuclear tubular inclusions in type II pulmonary alveolar epithelial cells of patients with bleomycin and busulfan toxicity.
Abundant intranuclear tubular structures were observed in type II alveolar pneumocytes in lung biopsies from patients with bleomycin and busulfan toxicity. It is proposed that since chromatin-membrane interactions in eukaryotic cell nuclei do occur, the intranuclear proliferation of the tubular structures occurs as a result of the interaction of the drug with perichromatin.
D001761:Bleomycin / Q000009:adverse effects*; D002066:Busulfan / Q000009:adverse effects*; D002467:Cell Nucleus / Q000648:ultrastructure*; D002843:Chromatin / Q000648:ultrastructure; D004848:Epithelium / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008870:Microtubules / Q000648:ultrastructure*; D011658:Pulmonary Fibrosis / Q000209:etiology
D002843:Chromatin; D001761:Bleomycin; D002066:Busulfan