Pipradrol-induced hyperthermia in the rabbit.
Intravenous administration of the stimulant drug pipradrol evoked a dose-dependent hyperthermic response in rabbits. This drug effect was significantly reduced by pretreatment with chlorpromazine, phenoxybenzamine, intravenous BE-2254 or intracerebroventricular BE-2254. In animals pretreated with cyproheptadine or atropine, the hyperthermic effect was significantly potentiated. However, haloperidol, pimozide, diphenhydramine and pentobarbital failed to appreciably influence the drug response. These findings suggest that pipradrol-induced hyperthermia in the rabbit involves activation of central alpha-adrenergic receptors and is apparently enhanced by blockade of serotonergic or cholinergic receptors.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004347:Drug Interactions; D007276:Injections, Intraventricular; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D011817:Rabbits; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D013997:Time Factors
D010880:Piperidines; D011942:Receptors, Adrenergic, alpha; D011950:Receptors, Cholinergic; D011985:Receptors, Serotonin