[Use of neonatal induction of enzymes for the correction of experimental hereditary enzymopathies].
Administration of enzyme-inducing agents into newborn animals resulted in stable changes of the activities of the relevant inducible enzymes for long periods of their life in adulthood. The phenomenon designated as enzymic imprinting was used for correction of inherited enzymopathies in animals. Neonatal administration of galactose into the W/ssm rats with inherited galactosemia stably decreased galactose transport into the erythrocytes, increased activities of hexose oxidizing enzymes and prevented development of cataracts and other galactosemia symptoms. Neonatal administration of the inducer of mixed function oxidases into the SWR/J mice with inherited hypercholesterolemia stably increased the activities of these cholesterol oxidizing enzymes and abolished the hypercholesterolemia symptoms in adulthood. It is suggested that enzymic imprinting is due to amplification of genes coding the inducible enzymes on account of preferential copying of the induced mRNA's by reverse transcription. It is shown that the enzymic induction was accompanied by activation of RNA dependent DNA synthesis and the activity of this enzymatic system was distinctly higher in newborn animals.
D000818:Animals; D000831:Animals, Newborn; D004247:DNA / Q000096:biosynthesis; D004259:DNA-Directed DNA Polymerase / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D005690:Galactose / Q000008:administration & dosage; D005693:Galactosemias / Q000188:drug therapy / Q000201:enzymology*; D006854:Hydrocortisone / Q000008:administration & dosage; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D051379:Mice; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D009713:Nucleotidyltransferases / Q000096:biosynthesis*; D010088:Oxidoreductases / Q000096:biosynthesis*; D011284:Pregnenolone / Q000008:administration & dosage / Q000031:analogs & derivatives; D012194:RNA-Directed DNA Polymerase / Q000096:biosynthesis; D051381:Rats; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase / Q000096:biosynthesis*
D011284:Pregnenolone; D004247:DNA; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D009713:Nucleotidyltransferases; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase; D012194:RNA-Directed DNA Polymerase; D004259:DNA-Directed DNA Polymerase; D006854:Hydrocortisone; D005690:Galactose
Korrektsiia nasledstvennykh fermentopatiĭ v éksperimente putem neonatal'noĭ induktsii fermentov.