[Humoral and cellular autoimmunity in genuine vitiligo studied by means of an antigen produced from melanoma cells].
Serum and lymphocytes of 11 vitiligo patients were examined for humoral antibodies and a specific sensibilization towards pigment cell protein by a melanom extract. Precipitating antibodies (Ouchterlony technique) and a specific sensibilization of vitiligo lymphocytes (lymphocyte transformation test) could not be identified by means of this antigen. The reason for the negative results obtained are discussed, with the antigen gained from malign degenerated cells being unsuitable with respect to the specific lymphocyte transformation test to identify a T-cell sensibilization of vitiligo patients towards melanocytes. It is probable that antigen changes due to the degeneration of melanocytes will render the antigen recognition more difficult because of lymphocytes sensibilized towards normal melanocytes and their components.
D000917:Antibody Formation; D000951:Antigens, Neoplasm / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D005779:Immunodiffusion; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000276:immunology*; D008875:Middle Aged; D014820:Vitiligo / Q000276:immunology*
D000951:Antigens, Neoplasm; D001323:Autoantibodies
Untersuchungen zur humoralen und zellulären Autoimmunität bei genuiner Vitiligo unter Verwendung eines aus Melanomzellen gewonnenen Antigens.