The in vivo effects of interleukin 2 (TCGF).
This brief review of our experiments concerning the in vivo activity of crude Il-2 led us to the following conclusion: The first is the existence, in vivo, of a cyclophosphamide-sensitive T-cell controlling the activity of a serum born Il-2 inhibitor in thymus-bearing normal mice. Under in vivo conditions which are characterized by high Il-2 inhibitor activities, locally applied Il-2 administered along with antigen amplified in vivo CTL-responsiveness, yet the effect observed was poor. Crude Il-2 proved to be a potent immuno-enhancing agent in the athymic (nu/nu) mouse, which lacks Il-2 inhibitor activity. It was found that together with antigen administration of Il-2 to nude mice results in the generation of highly reactive T-helper cells, as well as in the generation of alloreactive CTL.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008211:Lymphocyte Cooperation; D008222:Lymphokines / Q000097:blood / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D007376:Interleukin-2; D008222:Lymphokines