[Animal experiments on direct drug effects on disseminated intravascular coagulation (DIC) in asphyxic shock].
In a total of 41 rabbit fetus it could be demonstrated in an asphyxia model to what extent disseminated intravascular coagulation may be influenced by directly applying drugs in the foetal circulation. Administration of heparin or streptokinase in the umbilical vessels led to a decrease of fibrin sediments in the areas of terminal coagulation, whereas an increase was caused by injecting noradrenalin or PAMBA.
D010129:4-Aminobenzoic Acid / Q000009:adverse effects; D000818:Animals; D001237:Asphyxia / Q000150:complications*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D005333:Fetus; D006493:Heparin / Q000627:therapeutic use*; D007275:Injections, Intravenous; D009638:Norepinephrine / Q000009:adverse effects; D011817:Rabbits; D013300:Streptokinase / Q000627:therapeutic use*; D014471:Umbilical Veins; D062366:para-Aminobenzoates
D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D006493:Heparin; D013300:Streptokinase; D010129:4-Aminobenzoic Acid; D009638:Norepinephrine
Tierexperimente zur direkten Beeinflussung der disseminierten intravasalen Gerinnung (DIC) im asphyktischen Schock.