title: [Ecotoxicological study of chlorinated pesticides].
abstract: The authors describe a model for the ecotoxicological investigation of pesticide residues guided by the analysis of various links of the food chain and of human materials. It is pointed to the possibility of studying the dynamics of the exposure to human beings by analyzing gynaecological material (prenatal stage) and samples obtained at necropsy from human beings of varying age (different durations of exposure). The observations of the relative accumulation of hexachlorobenzene, beta-BHC and DDT in butter, human milk and human fat in a region with intensive cultivation revealed a considerble accumulation of hexachlorobenzene which reaches the level of DDT. The conclusion drawn from ecotoxicological studies indicates that a reduction of the tolerances of pesticide residues in raw materials for baby foods is imperative. The analyses of gynaecological material (202 samples of the available content of the uterus and 24 placental and embryonic specimens) permitted to evidence a significant difference between two regions and a specific relationship of the observed substances and their metabolites to the fat-dissolving power of the analyzed materials.
mesh_terms: D000273:Adipose Tissue / Q000032:analysis; D000328:Adult; D002079:Butter / Q000032:analysis; D003604:Czechoslovakia; D003634:DDT / Q000032:analysis; D004463:Ecology; D004622:Embryo, Mammalian / Q000032:analysis; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects; D005260:Female; D005504:Food Analysis; D006581:Hexachlorobenzene / Q000032:analysis; D001556:Hexachlorocyclohexane / Q000032:analysis; D006801:Humans; D007306:Insecticides / Q000009:adverse effects* / Q000032:analysis; D008895:Milk, Human / Q000032:analysis; D010573:Pesticide Residues / Q000009:adverse effects* / Q000032:analysis; D010920:Placenta / Q000032:analysis; D011247:Pregnancy
chemical_list: D004785:Environmental Pollutants; D007306:Insecticides; D010573:Pesticide Residues; D006581:Hexachlorobenzene; D001556:Hexachlorocyclohexane; D002079:Butter; D003634:DDT
vernacular_title: Okotoxikologische Studien über chlorierte Pestizide.