title: Interactions between developing autonomic neurons and their target tissues.
abstract: Neurons critically depend on contact with the correct target tissue in order to survive and mature. The number of neurons surviving in a nerve centre directly depends on the size of the peripheral field in innervates. It has been proposed that target tissues release a neurotrophic substance (retrophin) which is internalized by nerve terminals and retrogradely transported to the perikarya where its action results in the survival of appropriate neurons. In the sympathetic nervous system, nerve growth factor probably acts as a retrophin. Similar retrophins must exist for other neuronal systems. In order to identify a parasympathetic retrophin two approaches have been taken. One was to grow appropriate target tissues with radiolabelled amino acids and to determine whether the proteins synthesized and released by these target tissues were retrogradely transported by parasympathetic neurons in vivo. The other approach was to show that a purified neurotrophic factor for the chick ciliary ganglion could be retrogradely transported by parasympathetic neurons. The results have suggested that at least two retrophins are involved in the normal development of the autonomic nervous system: one, nerve growth factor, for the sympathetic nervous system and the other, as yet unnamed, for the parasympathetic system.
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D001370:Axonal Transport; D002478:Cells, Cultured; D005728:Ganglia, Sympathetic / Q000502:physiology*; D009414:Nerve Growth Factors / Q000494:pharmacology / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012160:Retina / Q000502:physiology; D012469:Salivary Glands / Q000294:innervation
chemical_list: D009414:Nerve Growth Factors