Establishment of an experimental model of human hepatoblastoma.
Establishment of xenografts or cell culture lines in which the alpha-fetoprotein (AFP) characteristic of clinical hepatoblastoma persists have been difficult. The serially transplantable strain (HB-3) of highly AFP-producing hepatoblastoma was successfully established in nude mice. And a highly AFP producing cell line (c-HB-3) is easily obtained by HB-3. This strain and line give us an ideal experimental model of hepatoblastoma in vivo and in vitro.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D002460:Cell Line; D005260:Female; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008114:Liver Neoplasms, Experimental; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins