Activity of di-beta-lysyl-capreomycin IIA and palmitoyl tuberactinamine N against drug-resistant mutants with altered ribosomes.
The effects of 61 synthetic tuberactinomycin derivatives on polypeptide synthesis were tested in bacterial cell-free systems. Di-beta-lys-capreomycin IIA was more effective than the natural product. Palmitoyl tuberactinamine N inhibited the growth of tuberactinomycin-resistant mutants and was not a ribosome inhibitor.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics; D002207:Capreomycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004776:Enviomycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D009154:Mutation; D012270:Ribosomes / Q000187:drug effects*; D014756:Viomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002207:Capreomycin; C033359:di-beta-lysyl capreomycin IIA; C033358:palmitoyl tuberactinamine N; C015563:tuberactinomycin; D004776:Enviomycin; D014756:Viomycin