[Effect of specific antibodies on active immunity development in those inoculated with an antirabies vaccine].
The study of the effect of gamma globulin introduced in different doses (0.5 and 0.25 ml/mg) in combination with Fermi rabies vaccine (observations on humans were made) and with cerebral rabies vaccine inactivated by UV irradiation (in animal experiments) demonstrated that the injection of the higher doses of gamma globulin resulted in lower geometrical mean of antibody titers. Therefore, in combined administration of rabies vaccine and gamma globulin for postexposure rabies prevention it is advisable to reduce the dose of gamma globulin by one-half.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D001733:Bites and Stings / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007110:Immunity, Active; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000528:radiation effects; D051381:Rats; D014466:Ultraviolet Rays; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000528:radiation effects; D005719:gamma-Globulins / Q000008:administration & dosage
D000914:Antibodies, Viral; D011819:Rabies Vaccines; D014613:Vaccines, Attenuated; D005719:gamma-Globulins
Vliianie spetsificheskikh antitel na vyrabotku aktivnogo immuniteta u privitykh antirabicheskoĭ vaktsinoĭ.