Diagnosis of cerebral Whipple's disease by cerebrospinal fluid cytology.
In a case of Whipple's disease the diagnosis was made by careful cytologic evaluation of the cerebrospinal fluid (CSF), identifying "Sieracki cells". A basal granuloma invaded the hypothalamus, diencephalon, and rostral parts of the brainstem. An exploration in the initial stage led to misdiagnosis as a granular cell tumor. Diagnosis was then confirmed by intestinal biopsy.
D000328:Adult; D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008934:Mitogens; D008061:Whipple Disease / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis / Q000628:therapy
D007070:Immunoglobulin A; D008934:Mitogens