Immunoregulatory action of type I interferon in the mouse.
The effect of type I interferon production on immunity to the interferon-inducing virus was examined using the Newcastle disease virus [NDV]-mouse model and comparing If-1h and If-1l animals. The degree of cell-mediated immunity, as measured by delayed hypersensitivity [DH] to NDV, was influenced by the levels of interferon produced. Anti-interferon globulin given immediately after immunization decreased sensitization to NDV, whereas additional, exogenous, interferon, given to low interferon producers, stimulated sensitization to NDV. The alleles at the If-1 locus influenced the extent of DH to NDV, in that If-1h mice developed much stronger DH than did If-1l mice. However, results from recombinant inbred strains, F2 and backcross generations showed that for interferon production to stimulate DH to NDV, other genes, present in the C57BL/6 background but as yet not characterized, are required. Thus DH to NDV is determined on the one hand by the alleles at If-1, influencing interferon production, and on the other hand by a combination of several genes affecting the interaction of interferon with cells of the immune system.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D005802:Genes, MHC Class II; D006968:Hypersensitivity, Delayed; D007109:Immunity / Q000187:drug effects; D007111:Immunity, Cellular; D007372:Interferons / Q000276:immunology* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009522:Newcastle disease virus / Q000276:immunology; D013997:Time Factors
D000941:Antigens; D007372:Interferons