Effects of tiapride on homovanillic acid levels in human cerebrospinal fluid drawn at pneumoencephalography.
The effect of tiapride on HVA and 5-HIAA levels in the CSF drawn at pneumoencephalography (PEG) was studied. Five consecutive 5 ml fractions of CSF were drawn from control and tiapride-treated subjects. In both groups, a linear increase in HVA concentrations was found between the first and subsequent fractions. On the contrary, no significant difference in 5-HIAA concentrations was found in sequential CSF samples. Tiapride increased the mean HVA concentrations and caused a steeper caudocranial gradient of this metabolite but failed to modify 5-HIAA concentrations. The results suggest that tiapride blocks dopamine (DA) receptors and increases DA synthesis.
D000328:Adult; D001549:Benzamides / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D011011:Pneumoencephalography; D013976:Tiapamil Hydrochloride / Q000494:pharmacology*
D001549:Benzamides; D010648:Phenylacetates; D006897:Hydroxyindoleacetic Acid; D013976:Tiapamil Hydrochloride; D006719:Homovanillic Acid