Effect of malnutrition during pregnancy on the development of the mammary glands of rats.
Sprague-Dawley rats fed 50% of normal food intake from day 5 of gestation had a marked reduction in the weight of their left mammary glands compared with control nonrestricted animals. The affected glands had a significant reduction in DNA, RNA and protein content. Protein/DNA ratio was also reduced while RNA/DNA ratio was unchanged. Histological studies of the glands revealed a reduced number of parenchymal cells, reduced cell size and larger lumen within the alveoli.
D000818:Animals; D004247:DNA / Q000378:metabolism; D005260:Female; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D009929:Organ Size; D011247:Pregnancy; D011270:Pregnancy, Animal; D011488:Protein Deficiency / Q000503:physiopathology*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D011506:Proteins; D012313:RNA; D004247:DNA