Identification of new murine lymphocyte alloantigens: antisera prepared between C57L, 129 and related strains define new loci.
Antisera prepared by immunizing between the strains 129 and C57L and other related strains identified new antigens expressed on lymphocytes and in particular on thymocytes. Absorption analysis demonstrated that the antisera were complex, and contained several new antibodies including some which were not cytotoxic, but could be detected by rosetting. The loci defined by these antibodies are referred to as Ly-9, Ly-11, Ly-12, Ly-13, and Ly-14, although several of the antigens were not confined to lymphocytes. In addition, the Ea-7 specificities, previously considered to be purely red-cell alloantigens, were also found on thymocytes.
D000042:Absorption; D000417:Albinism / Q000235:genetics / Q000276:immunology; D000483:Alleles; D000818:Animals; D000961:Antilymphocyte Serum / Q000235:genetics / Q000494:pharmacology; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D007519:Isoantigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012397:Rosette Formation
D000961:Antilymphocyte Serum; D000939:Epitopes; D007519:Isoantigens