[Concentration of heterogeneous leukocyte interferon].
A comparative study of different methods for concentration of porcine leukocyte interferon active in human cells was carried out. Ultrafiltration in an apparatus TCF-10 was found to be the most effective method of concentration by which preparations of porcine interferon showing antiviral activity up to 1 X 10(6) IU/ml were obtained. The total antiviral activity of concentrated interferon was twice as high as that of the native preparation. This increase of the total initial activity is due to the removal in the process of concentration of an inhibitor of antiviral activity which was isolated and concentrated. The concentrated preparation of porcine leukocyte interferon is now undergoing trials in veterinary and medicine.
D000818:Animals; D004355:Drug Stability; D006801:Humans; D007158:Immunologic Techniques; D007372:Interferons / Q000037:antagonists & inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D007962:Leukocytes / Q000276:immunology*; D051379:Mice; D011817:Rabbits; D013552:Swine; D014462:Ultrafiltration / Q000379:methods; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D007372:Interferons
Kontsentrirovanie geterogennogo leĭkotsitarnogo interferona.