Evaluation of the effects of SKF 82526 and LY 171555 on presynaptic (DA2) and postsynaptic (DA1) dopamine receptors in rat kidney.
Effects of dopamine receptor agonists, SKF 82526 and LY 171555 on presynaptic (DA2) and postsynaptic (DA1) dopamine receptors were studied in the isolated perfused rat kidney. SKF 82526 failed to alter [3H]NA release elicited during periarterial nerve stimulation in the kidney whereas LY 171555 caused a concentration-dependent inhibition of the stimulus-induced release of [3H]NA. This inhibitory action of LY 171555 could be antagonized by sulpiride but not by SCH 23390. SKF 82526 caused concentration-dependent renal vasodilation which could be antagonized by SCH 23390. LY 171555 did not produce significant changes in renal perfusion pressure over a wide range of concentrations. These results show that SKF 82526 and LY 171555 are selective agonists at DA1 and DA2 receptors respectively. These agents represent an important class of compounds that would be useful for pharmacological characterization of peripheral dopamine receptors.
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004558:Electric Stimulation; D004873:Ergolines / Q000494:pharmacology*; D018818:Fenoldopam; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects
D001552:Benzazepines; D004873:Ergolines; D011954:Receptors, Dopamine; D017981:Receptors, Neurotransmitter; D019257:Quinpirole; D013469:Sulpiride; D018818:Fenoldopam; D009638:Norepinephrine