[Computerized analysis of cardiovascular activity in the conscious unrestrained rat. Application to the study of a new antihypertensive agent].
A more precise knowledge of cardiovascular activity in rats needs its direct recording for long periods of time, in conscious unrestrained animals. A system has been developed, which allows direct recording of blood pressure (BP) in freely moving rats, by means of a floating catheter chronically inserted in the abdominal aorta, connected to a rotating swivel, and then to a pressure transducer. A mini-computer performs on-line processing of BP curves, and stores the values of 5 cardiovascular parameters on hard disk: systolic, diastolic and mean arterial pressures, heart rate and dp/dt max. Off line processing allows graphic and statistical analysis of the data. Simultaneously recording from two rats is very useful in pharmacology because a treated animal and a control one are studied at the same time and in the same conditions. This methodology was used to evaluate the effects of a chronic treatment (2 mg/kg, ip, during 8 days) and of single injections (0.5 and 3 mg/kg, iv) of a new antihypertensive substance, CM 40441a, in 15 W old males SHR.
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008905:Minicomputers; D009930:Organic Chemicals; D051381:Rats; D011918:Rats, Inbred SHR
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D009930:Organic Chemicals; C044439:CM 40441a
Analyse informatisée de l'activité cardiovasculaire chez le rat conscient et non restreint. Application à l'étude d'un nouvel antihypertenseur.