Pharmacokinetics of high molecular weight hydroxyethyl starch in dogs.
The elimination of high molecular weight hydroxyethyl starch (HMW-HES) was determined in dogs. . Eight dogs were divided into two groups; one of which was bled 25 ml/kg. Both groups were given 25 ml/kg of 6% HMW-HES solution over a 30 min period. There was no significant difference in plasma concentration vs time profiles between the two groups. The biological half-life estimated between days 7-28, averaged 7.5 and 8.4 days in control and bled dogs, respectively. The renal clearance of HMW-HES diminished considerably in both groups during the 7 day period. Despite large interanimal variations in renal clearance, there was not a significant difference between groups.
D000818:Animals; D004285:Dogs; D006207:Half-Life; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000378:metabolism*; D007700:Kinetics; D008970:Molecular Weight; D051381:Rats; D013045:Species Specificity; D013213:Starch / Q000031:analogs & derivatives*; D000516:alpha-Amylases / Q000378:metabolism
D006895:Hydroxyethyl Starch Derivatives; D013213:Starch; D000516:alpha-Amylases