Effect of angiotensin I converting enzyme inhibitor, SQ 14225, on renin production and release.
Renin production and release induced by angiotensin I converting enzyme inhibitor (CEI), SQ 14225, were studied in male Wistar rats. Acute studies on the effects of CEI (4.6 mumol/kg, i.m. every 6 h for 48 H) in rats revealed a significant reduction in angiotensin II levels and a marked increase in plasma renin activity (PRA). There were no appreciable changes in renal content (RRC) and the juxtaglomerular cell granulation index (JGI). In rats which had received CEI in their drinking water (0.92 mumol/ml) for 12 days, angiotensin II levels were decreased markedly and urinary excretion of sodium was increased, but the reduction in blood pressure was slight. PRA, JGI and RRC were markedly increased in these animals. The kidneys of CEI-treated rats exhibited conspicuous vascular dilatation. CEI treatment of sodium-depleted rats resulted in a reduction of the increased JGI and RRC and in a further increase in PRA. Our findings suggest that CEI administration may initially effect stimulation of renin release from the juxtaglomerular apparatus and that prolonged CEI administration results in a gradual stimulation of renin production.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D007606:Juxtaglomerular Apparatus / Q000187:drug effects; D007668:Kidney / Q000378:metabolism; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000096:biosynthesis*; D012084:Renin-Angiotensin System / Q000187:drug effects; D013268:Stimulation, Chemical; D013722:Teprotide
D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; D011392:Proline; D002216:Captopril; D013722:Teprotide; D012083:Renin