Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease.
We report a patient with a disease characterized by proliferation of T cells with Fc receptors for IgG (TG). However, unlike lymphoid cells from normal individuals or from patients with other lymphoid malignancies, the patient's lymphocytes spontaneously produced gamma interferon (IFN-gamma) in vitro. The peripheral lymphocytes consisted of 95% TG cells, which exhibited the morphological characteristics of T-cell chronic lymphocytic leukemia (CLL) and were normal on cytochemical and chromosome analysis. The majority of TG cells were OKT3+, OKT8+, and OKT4-, 3A1-. These cells failed to express suppressor cell activity and displayed depressed levels of natural killer activity, but mediated antibody-dependent cell-mediated cytotoxicity. The spontaneous production of IFN-gamma by human peripheral lymphoid cells as demonstrated in this study may serve as a probe for studying the relationship between IFN-gamma and the proliferation of human T-cell subsets.
D002478:Cells, Cultured; D006801:Humans; D007074:Immunoglobulin G; D007372:Interferons / Q000096:biosynthesis*; D007945:Leukemia, Lymphoid / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism*; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011961:Receptors, Fc; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D007074:Immunoglobulin G; D011961:Receptors, Fc; D007372:Interferons