Relationship of the central ACTH-immunoreactive opiocortin system to the supraoptic and paraventricular nuclei of the hypothalamus of the rat.
ACTH-immunoreactive (ir) fibers of the central opiocortin system are present in high density in the mid-portion of the paraventricular nucleus (PVN). ACTH-ir fibers, however, do not appear to directly contact oxytocin-ir vasopressin-ir, containing perikarya or axons of vasopressinergic neurons. Magnocellular neurons located more anteriorly and posteriorly in the PVN as well as those located laterally have few ACTH-ir fibers associated with them. No ACTH-ir fibers are present in the supraoptic nucleus.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D001370:Axonal Transport; D003712:Dendrites / Q000648:ultrastructure; D004723:Endorphins / Q000378:metabolism*; D007031:Hypothalamus / Q000033:anatomy & histology*; D008297:Male; D008473:Median Eminence / Q000033:anatomy & histology; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D009412:Nerve Fibers / Q000648:ultrastructure; D010121:Oxytocin / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000033:anatomy & histology*; D051381:Rats; D011919:Rats, Inbred Strains; D013495:Supraoptic Nucleus / Q000033:anatomy & histology*; D008083:beta-Lipotropin / Q000378:metabolism*
D004723:Endorphins; D001127:Arginine Vasopressin; D010121:Oxytocin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin