title: Focal and generalized experimental seizures induced by homocysteine.
abstract: Electrocorticographic and behavioral effects of parenteral injections of homocysteine in rats are described. Homocysteine activates experimental foci and produces focal seizures in experimental animals with pre-existing lesions. It produces generalized ECoG seizures and generalized convulsions in unlesioned animals in higher doses.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006710:Homocysteine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012640:Seizures / Q000139:chemically induced*
chemical_list: D006710:Homocysteine