[Antiviral action of swine leukocyte interferon in mouse experiments].
Swine leukocytes had previously been found to produce interferon which has an antiviral effect not only in swine cells but also in human cells. Preliminary experiments in tissue cultures showed the culture of primarily trypsinized mouse embryo fibroblasts to be as sensitive to swine interferon as human diploid cells. The experiment studying the antiviral effect of swine leukocyte interferon in the animals demonstrated it to protect mice against the pathogenic A/Aishi/68 (H3N2) strain; with a reduction of virus doses to 10 the protective effect of swine interferon increased 2-fold as compared with the experiments using 100-1000 virus doses. Inhibition of virus reproduction in lung tissues of experimental mice inoculated with A/Moscow/23/78 (H1N1), A/Wisconsin/19/67 (Hsw1N1) and A/Aishi/68 (H3N2) strains as compared with the controls. The experimental results suggest that the swine interferon produces the antiviral effect both in tissue culture and experimental animals.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000628:therapy; D007372:Interferons / Q000627:therapeutic use*; D007739:L Cells / Q000187:drug effects; D007962:Leukocytes / Q000276:immunology*; D051379:Mice; D009522:Newcastle disease virus / Q000187:drug effects; D013552:Swine / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014776:Virus Cultivation
D007372:Interferons
Antivirusnoe deĭstvie svinogo leĭkotsitarnogo interferona v éksperimentakh na myshakh.