Antiviral and interferon-inducing properties of interferon inducers administered with prostaglandins.
Prostaglandins enhanced the interferon response and therapeutic activity of interferon inducers in Friend leukemia virus-infected mice. A similar enhancement in interfron responsiveness but not antiviral activity was observed in mice infected with rapidly acute viruses.
D000818:Animals; D004357:Drug Synergism; D005260:Female; D005622:Friend murine leukemia virus; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000097:blood; D007942:Leukemia, Experimental / Q000097:blood / Q000188:drug therapy*; D008297:Male; D051379:Mice; D011070:Poly I-C / Q000627:therapeutic use; D011458:Prostaglandins E / Q000627:therapeutic use*; D011460:Prostaglandins F / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D013994:Tilorone / Q000627:therapeutic use; D014777:Virus Diseases / Q000188:drug therapy*
D007369:Interferon Inducers; D011458:Prostaglandins E; D011460:Prostaglandins F; D011743:Pyrimidines; C014927:2-amino-5-bromo-6-methyl-4-pyrimidinol; D007372:Interferons; D013994:Tilorone; D011070:Poly I-C