The congenital factor VII abnormalities (dysproconvertinemias). The genetic plot thickens.
Congenital factor VII deficiency is a well known clotting disorder first identified in 1951. Several congenital abnormalities of factor VII have been described during the past decade. These abnormalities were all characterized by the presence of a discrepancy between factor VII clotting activity and factor VII cross reacting material or antigen. Recently other factor VII abnormalities have been described which showed peculiar sensitivities to ox-brain thromboplastins as compared to thromboplastins of other origin. These discoveries have complicated the differential diagnosis of prothrombin complex factors deficiences and abnormalities. A correct diagnosis may be reached only by means of a battery of tests which employ tissue thromboplastins of different origin.
D000818:Animals; D000941:Antigens; D001778:Blood Coagulation Disorders / Q000151:congenital / Q000175:diagnosis*; D002417:Cattle; D003429:Cross Reactions; D005167:Factor VII / Q000276:immunology*; D006801:Humans; D013925:Thromboplastin
D000941:Antigens; D005167:Factor VII; D013925:Thromboplastin