Anti-coagulant and anti-thrombotic effects of some protease inhibitors.
Several synthetic tri-peptide enzyme inhibitors of the general sequence Phe-Pro-Arg were studied in vitro and in vivo. Extent and specificity of inhibition of thrombin were different. The inhibitors exert anti-coagulant effects in vitro. The anti-coagulant effect in vivo was used as a measure of bioavailability and duration of action. The tri-peptide inhibitors are rapidly eliminated from the circulation and produce a decrease in blood pressure. Anti-thrombotic effects were demonstrated in a thrombosis model in rabbits.
D000818:Animals; D000925:Anticoagulants; D001777:Blood Coagulation / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D005343:Fibrinolytic Agents; D006801:Humans; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013917:Thrombin / Q000037:antagonists & inhibitors
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D009842:Oligopeptides; D011480:Protease Inhibitors; D013917:Thrombin