title: A cis-acting regulator of enzyme tissue specificity in Drosophila is expressed at the RNA level.
abstract: Alcohol dehydrogenase (ADH) is expressed according to qualitatively different patterns in Drosophila grimshawi and two closely related species, D. orthofascia and D. formella. This regulatory difference is under control of a cis-acting genetic factor. The ADH of these species is very similar to ADH of D. melanogaster and a genomic ADH clone derived from the latter hybridizes specifically to ADH coding sequences of the other species. Using this hybridization probe, it is shown that the above cis-acting regulator acts before or shortly after transcription to control ADH expression.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D004330:Drosophila / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics; D005815:Genetic Code; D007814:Larva / Q000201:enzymology; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000235:genetics; D013045:Species Specificity; D014158:Transcription, Genetic
chemical_list: D012313:RNA; D004247:DNA; D000429:Alcohol Oxidoreductases