title: Pathogenicity of newly isolated coxsackievirus B4 for mouse pancreas.
abstract: Coxsackievirus B4 fresh isolates from patients with upper respiratory illness and aseptic meningitis were studied for their pathogenicity in the pancreas of SJL/J mice. Out of 12 virus isolates, 7 induced hypoglycaemia in mice 2 to 4 days after virus inoculation. All 3 isolates from faeces of patients induced hypoglycaemia in contrast to 3 viruses isolated from the cerebrospinal fluid which did not. Six isolates from throat swabs were either pathogenic (4 isolates) or non-pathogenic (2 isolates). It is concluded that at least two biologically distinct coxsackieviruses B4 prevail among humans.
mesh_terms: D000818:Animals; D029822:Enterovirus B, Human / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D051379:Mice; D010179:Pancreas / Q000382:microbiology; D010182:Pancreatic Diseases / Q000382:microbiology*; D013045:Species Specificity