The palliative role of hepatic arterial infusion and arterial occlusion in colorectal carcinoma metastatic to the liver.
Fifty-five patients with metastatic colorectal carcinoma confined to the liver were treated with hepatic arterial infusion of floxuridine and mitomycin C. Tumour response rate was 43.4% and median overall survival was 11 months. Prolonged survival was associated with intentional or inadvertent occlusion of the hepatic artery. The median survival of twenty-four patients with arterial occlusion (15 months) was significantly higher than that of thirty-one patients without arterial occlusion (8 months).
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003110:Colonic Neoplasms / Q000601:surgery; D004621:Embolization, Therapeutic; D005467:Floxuridine / Q000008:administration & dosage; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008026:Ligation; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000556:secondary / Q000628:therapy*; D008937:Mitomycins / Q000008:administration & dosage; D010166:Palliative Care; D012004:Rectal Neoplasms / Q000601:surgery
D000970:Antineoplastic Agents; D008937:Mitomycins; D005467:Floxuridine