Effect on influenza virus infection on the production of interferon by alveolar and peritoneal cells in vitro.
The investigation was carried on mice infected with influenza A/053/74/H3N2 virus. 129/Ao/Boy, inbred mice, were inoculated intranasally with influenza virus. The alveolar and peritoneal cells from infected and uninfected animals were induced in vitro with Newcastle disease virus. It was shown that the alveolar cells from infected mice produce more interferon than the cells from control mice, but the peritoneal cells from both groups of animals produced the same amount of interferon.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D066298:In Vitro Techniques; D009980:Influenza A virus; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009522:Newcastle disease virus; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D011650:Pulmonary Alveoli / Q000473:pathology
D007369:Interferon Inducers; D007372:Interferons