Dissolution, stability, and absorption characteristics of dicumarol in polyethylene glycol 4000 solid dispersions.
The dissolution characteristics of dicumarol were markedly enhanced by preparing dispersions of drug in polyethylene glycol 4000. Solid dispersions of varying weight fractions were formed by a melt method without measurable drug degradation or evaporation. There were no significant differences in dissolution rates among weight fractions, with dynamic solubilities being approximately 2.5 times greater than dicumarol's equilibrium solubility. No indications of drug polymer complexation were noted from equilibrium or in situ absorption experiments. Incorporation of solid dispersions into direct compression tablets provided dosage forms with fast-release properties relative to test tablets of physical mixtures and a commercially available product. Percentages dissolved in 30 min were 370% greater for 1:3 and 1:5 (w/w) solid dispersion tablets compared to a commercial tablet at 37 degrees with a pH 7.5 dissolution buffer. X-ray diffraction of test powder revealed that the crystalline nature of the drug had altered during fusion preparation. Dissolution traits and drug stability for solid dispersions were maintained over 1 year of storage.
D000042:Absorption; D001728:Dicumarol / Q000008:administration & dosage*; D004339:Drug Compounding; D004355:Drug Stability; D011092:Polyethylene Glycols; D011208:Powders; D012995:Solubility; D013607:Tablets; D013997:Time Factors; D014961:X-Ray Diffraction
D011208:Powders; D013607:Tablets; D011092:Polyethylene Glycols; D001728:Dicumarol