[Serum concentrations of alpha 1-fetoprotein in acute hepatic failure treated by hemoperfusion with baboon livers (author's transl)].
9 patients with acute hepatic necrosis following virus hepatitis or hepatic intoxication and 2 patients with acute necrosis of cirrhotic liver, all with stage IV or V hepatic coma, were treated by hemoperfusions with baboon livers. Serum levels of alpha 1-fetoprotein (AFP) were examined prae-, intra- and post perfusion by radioimmunoassay. In 4 patients who survived, the AFP-levels increased from 20 to 65 ng/ml to 180 to 480 ng/ml and remained raised for more than one week. In the patients who died of liver insufficiency, the AFP-levels were only slightly or temporarily increased. The alpha 1-fetoprotein determination is a reliable criterium for the prognosis of hepatic coma patients treated by hemoperfusion.
D000328:Adult; D000818:Animals; D002648:Child; D005260:Female; D006464:Hemoperfusion / Q000379:methods*; D006501:Hepatic Encephalopathy / Q000097:blood / Q000628:therapy*; D006801:Humans; D008099:Liver; D008297:Male; D008875:Middle Aged; D010215:Papio; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins
Serumkonzentration von Alpha 1-Fetoprotein bei extrakorporaler Pavianleberperfusion zur Behandlung von Patienten mit akutem Leberversagen.