Effect of des-Tyr1-gamma-endorphin on serotonin metabolism in rat brain regions.
Intracerebroventricular (i.c.v.) administration of des-Tyr1-gamma-endorphin (0.1 and 1.0 microgram) caused a decrease of the serotonin (5-HT) concentration of the hippocampus. The concentration of 5-HIAA and the pargyline-induced alterations in 5-HT and 5-HIAA were not affected. No effects were noticed in other brain regions.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004723:Endorphins / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D004723:Endorphins; D010446:Peptide Fragments; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C018903:gamma-endorphin, des-Tyr(1)-; D010293:Pargyline