[Pharmacokinetics and pharmacodynamics of vecuronium in children].
Pharmacodynamics of vecuronium have been studied in children 1 to 10 years old. Doses from 0.015 to 0.1 mg/kg were given and the effects measured mechanically and by electromyography. For 0.1 mg/kg the pharmacokinetics were established. A smaller distribution volume and higher plasma clearance in children as compared to adults have been found, while the dose-effect ratio is the same. The action of vecuronium is shorter in children than in adults.
D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D005260:Female; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D008838:Microcomputers; D009119:Muscle Contraction / Q000187:drug effects; D009213:Myography; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D010197:Pancuronium
Pharmacocinétique et pharmacodynamique du vécuronium chez l'enfant.