[Relation between extra- and intracardiac anti-strophanthin properties of anti-arrhythmic agents].
Animal experiments have shown that beta-adrenoblockers have the most marked antistrophanthin properties while antiarrhythmic agents with locally anesthetic attributes are less active. All the substances studied have proved to be ineffective on the cellular model of strophanthin arrhythmia. The data obtained suggest that the antiarrhythmic effect of the substances under study including beta-adrenoblockers is exercised on the level of the receptor apparatus of the postsynaptic membrane. The membrane stabilizing properties do not play the decisive role in ensuring the antiarrhythmic effect in strophanthin arrhythmia.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002462:Cell Membrane / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D013328:Strophanthins / Q000037:antagonists & inhibitors*
D000319:Adrenergic beta-Antagonists; D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D013328:Strophanthins; C029082:strophanthin K
Sootnoshenie ékstra- i intrakardial'nykh antistrofantinovykh svoĭstv antiaritmicheskikh veshchestv.