The influence of a new corticosteroid, budesonide, on anaphylactic bronchoconstriction and SRS-A release in the guinea pig.
Groups of guinea pigs sensitized with ovalbumin were treated with budesonide and beclomethasone dipropionate, respectively, in an intraperitoneal dose of 50 mg/kg. 20 h later, the anaphylactic release of histamine and slow reacting substance of anaphylaxis (SRS-A) from chopped lung tissue was studied. Whereas the corticosteroids studied had no effect on the tissue content of histamine or on the amount of antigen-induced release of this autacoid, budesonide and beclomethasone dipropionate to a great extent inhibited the release of SRS-A. The anti-anaphylactic effect of budesonide and beclomethasone was also shown in sensitized guinea pigs pretreated with mepyramine, 2.5 mg/kg intraperitoneally, and challenged with nebulized ovalbumin. We suggest that the partial protection given by the corticosteroids budesonide and beclomethasone dipropionate is due to the inhibiton of SRS-A release.
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D001507:Beclomethasone / Q000494:pharmacology; D001986:Bronchial Spasm / Q000517:prevention & control*; D019819:Budesonide; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D007114:Immunization; D008297:Male; D011282:Pregnenediones / Q000494:pharmacology*; D012140:Respiratory Tract Diseases / Q000139:chemically induced; D013189:SRS-A / Q000378:metabolism*
D005938:Glucocorticoids; D011282:Pregnenediones; D013189:SRS-A; D019819:Budesonide; D001507:Beclomethasone