Polyacrylamide gel electrophoresis of cerebrospinal fluid proteins in children with nontumoral hydrocephalus.
The changes occurring in the electrophoretic pattern of the cerebrospinal fluid (CSF) proteins in 37 children with nontumoral hydrocephalus, and the protein pattern of 12 children without organic neurological disease, were studied with polyacrylamide gel electrophoresis. In nontumoral hydrocephalus protein was frequently increased in lumbar and ventricular fluid, in this condition, in intraventricular obstruction, the protein fractions showed a decrease in the prealbumin and an increase in the gamma-globulin fractions, and in extraventricular obstruction, the protein fractions showed a decrease in the prealbumin and an increase in the gamma-globulin and alpha 2-globulin fractions. With CSF proteins within normal ranges we found that in intraventricular obstruction, the proteins of the ventricular-CSF showed an increase in the prealbumin and/or albumin fractions, and in extraventricular obstruction, the proteins of the ventricular CSF showed an increase in the prealbumin and beta-globulin fractions, and the proteins of the lumbar CSF showed an increase in the prealbumin fraction. The diagnostic implications of these findings are discussed.
D000418:Albumins / Q000032:analysis; D000510:Alpha-Globulins / Q000032:analysis; D001609:Beta-Globulins / Q000032:analysis; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D002648:Child; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005916:Globulins / Q000032:analysis; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D011228:Prealbumin / Q000032:analysis; D005719:gamma-Globulins / Q000032:analysis
D000418:Albumins; D000510:Alpha-Globulins; D001609:Beta-Globulins; D002556:Cerebrospinal Fluid Proteins; D005916:Globulins; D011228:Prealbumin; D005719:gamma-Globulins