Sensitization capacity of acrylated prepolymers in ultraviolet curing inks tested in the guinea pig.
One commonly used prepolymer in ultraviolet (UV) curing inks is epoxy acrylate. Of 6 men with dermatitis contracted from UV-curing inks, 2 had positive patch test reaction to epoxy acrylate. None reacted to the chemically related bisphenol A dimethacrylate. The sensitization capacity of epoxy acrylate and bisphenol A dimethacrylate performed with the "Guinea pig maximization test" (GPM) shows epoxy acrylate to be an extreme sensitizer and bisphenol A dimethacrylate a moderate sensitizer. Cross-reaction between the two substances occurs. The epoxy resin oligomer MW 340 present in the epoxy acrylate also sensitized some animals.
D000179:Acrylates / Q000009:adverse effects / Q000633:toxicity*; D000818:Animals; D001559:Benzhydryl Compounds; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced; D004853:Epoxy Resins / Q000009:adverse effects / Q000633:toxicity*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D007281:Ink; D008689:Methacrylates / Q000009:adverse effects / Q000633:toxicity*; D010328:Patch Tests; D011327:Printing / Q000379:methods; D014466:Ultraviolet Rays; D000098826:Bisphenol A Compounds
D000179:Acrylates; D001559:Benzhydryl Compounds; D004853:Epoxy Resins; D008689:Methacrylates; C029420:bisphenol A epoxy resin diacrylate ester; D000098826:Bisphenol A Compounds; C002462:4,4'-isopropylidenediphenol dimethacrylate