[In vivo measurement, by differential pulse voltammetry, of 5-HIAA in the striatum of the rat].
Differential pulse voltammetry, performed with electrically treated carbon fiber electrodes, enables us to detect in vitro or in vivo in the striatum of anesthetized Rats, an oxidation peak 3 at a potential of +300 mV. Electrolytic, or 5,7-dihydroxytryptamine lesions of the medial forebrain bundle are followed by a decrease of respectively 59 and 62% of this peak. Biochemical measurements are significantly correlated to the measured peaks 3 and troughs. Thus, peak 3 increases obtained after injection of L-tryptophane and/or reserpine, as well as the troughs observed after injection of clorgyline and/or NSD 1015 confirm that the peak 3 is dependent upon 5-hydroxyindolacetic acid (5-HIAA) concentration.
D000818:Animals; D001592:Benzyl Alcohols / Q000494:pharmacology; D003010:Clorgyline / Q000494:pharmacology; D003342:Corpus Striatum / Q000032:analysis*; D004563:Electrochemistry; D005110:Extracellular Space / Q000032:analysis; D006834:Hydrazines / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008297:Male; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D014364:Tryptophan / Q000494:pharmacology
D001592:Benzyl Alcohols; D006834:Hydrazines; D006897:Hydroxyindoleacetic Acid; D012110:Reserpine; D014364:Tryptophan; C004297:3-hydroxybenzylhydrazine; D003010:Clorgyline
Mesure in vivo, par voltamétrie impulsionnele différentielle du 5-HIAA dans le striatum du rat.