Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect.
Male and female progeny of a cross between CBA/N female and BALB/c male mice were tested for their ability to generate autoantigen-specific suppressor cells as a result of stimulation with crossreacting rat RBC. Male mice, hemizygous for the X-linked defect, were unable to generate these antigen-specific suppressor cells, whereas their female littermates behaved like the normal (CBA/Ca x BALB/c)F1 mice.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D003433:Crosses, Genetic; D000939:Epitopes; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D012727:Sex Characteristics; D012729:Sex Chromosome Aberrations / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014960:X Chromosome
D000941:Antigens; D001324:Autoantigens; D000939:Epitopes; D003208:Concanavalin A