Inhibition by lymph node cells and promotion by fetal hepatocytes of murine tumours without or with chemotherapy.
The growth of a syngeneic Moloney lymphoma in CBA mice was inhibited by the injection of lymph node cells from normal CBA donors. This cytotherapeutic effect was also seen after chemotherapy with cyclophosphamide (CY) or dimethylmyleran (DMM). Two other murine tumours, the Meth A sarcoma in Balb/c mice and the L1210 leukemia in BDF1 mice, did not respond to treatment with normal syngeneic cells. In the L1210 system, tumour-promoting effects of fetal liver cells were demonstrated. The tumour inhibitory effects of normal lymph node cells against the Moloney lymphoma may be a virus-dependent phenomenon mediated through interferon and natural killer' cells. The experiments also showed the sensitivity of the Moloney lymphoma and the Meth A sarcoma to CY and DMM and the responsiveness of the L1210 leukemia to AAFC.
D003504:Ancitabine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002066:Busulfan / Q000031:analogs & derivatives / Q000627:therapeutic use; D002273:Carcinogens; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology; D008099:Liver / Q000196:embryology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008979:Moloney murine leukemia virus; D009374:Neoplasms, Experimental / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000276:immunology
D000970:Antineoplastic Agents; D002273:Carcinogens; C002037:dimethylmyleran; C011168:5-fluoro-2,2'-cyclocytidine; D003520:Cyclophosphamide; D003504:Ancitabine; D002066:Busulfan