[The treatment of Wilm's tumor, improvements and new trends. A study of 724 cases treated at the Gustave-Roussy Institute. 1952-1980 (author's transl)].
Study of 724 cases of Wilm's tumor treated between 1952 and 1980 at the Gustave-Roussy Institute, according to 5 successive therapeutic protocols with or without chemotherapy (Actinomycin alone or Actinomycin and Vincristine). Recovery rates change from 44 to over 90% during this period. Improvement of survival was first obtained by the efficient treatment of metastases, then by preventing their development with systematic chemotherapy with Actinomycin and Vincristine. Rate of survival without relapse changed from 38 to 71 and 86%. Thus, the decrease in the number of patent metastases subjected to heavy treatments responsible for severe respiratory and orthopedic sequelae improved the quality of survival of these children.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003609:Dactinomycin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D009392:Nephrectomy; D011379:Prognosis; D014750:Vincristine / Q000008:administration & dosage*; D009396:Wilms Tumor / Q000556:secondary / Q000628:therapy*
D003609:Dactinomycin; D014750:Vincristine
Progrès et perspectives dans le traitement du néphroblastome. Etude de 724 cas traités à l'Institut Gustave-Roussy de 1952 à 1980.