title: Reactivity with rabbit immunoglobulin G of cold agglutinins isolated from group C streptococcal antisera.
abstract: Cold agglutinin antibodies were isolated from group C streptococcal antisera by thermal elution from rabbit erythrocytes. These antibodies reacted with bovine submaxillary mucin, fetuin, immunoglobulin G, and the Fc fragment of immunoglobulin G in hemolytic inhibition assays. Further, in radioimmunoassay these antibodies reacted with the major glycopeptide fragment of rabbit immunoglobulin G. Affinity-purified group carbohydrate-specific antibodies reacted weakly with glycopeptide. These data suggest that certain populations of antibody in group C streptococcal antisera may participate in tissue reactivity via interaction with cell surface glycoproteins, including immunoglobulin G.
mesh_terms: D000373:Agglutinins / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial; D000918:Antibody Specificity; D003429:Cross Reactions; D000939:Epitopes; D006023:Glycoproteins / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M; D011817:Rabbits; D013291:Streptococcus / Q000276:immunology*; D013329:Structure-Activity Relationship
chemical_list: D000373:Agglutinins; D000907:Antibodies, Bacterial; D000939:Epitopes; D006023:Glycoproteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M