title: Diesel exhaust - an occupational carcinogen?
abstract: The existence of polycyclic aromatic hydrocarbons (PAH) in the particulate phase of diesel engine exhaust has raised concern about a carcinogenic effect in workers exposed to exhaust from diesel engines. Some of the PAH are carcinogenic following inhalation by experimental animals and are associated with excess cancer mortality in some occupational exposures. Studies of occupational exposure to diesel exhaust show concentrations of PAH are above ambient levels but below the very high levels in occupations with demonstrated excess cancer mortality. A critical review of the epidemiologic evidence on the carcinogenicity of workplace exposure to diesel engine exhaust is suggestive of a carcinogenic effect but the existing data are sparse and contradictory. Further epidemiologic studies of this question are needed.
mesh_terms: D001580:Benzopyrenes / Q000506:poisoning; D002274:Carcinogens, Environmental; D005387:Finland; D005648:Fuel Oils; D006801:Humans; D008131:London; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology; D008906:Mining; D009784:Occupational Diseases / Q000209:etiology*; D010578:Petroleum; D011083:Polycyclic Compounds / Q000506:poisoning; D011890:Railroads; D014481:United States; D001335:Vehicle Emissions / Q000506:poisoning*
chemical_list: D001580:Benzopyrenes; D002274:Carcinogens, Environmental; D005648:Fuel Oils; D010578:Petroleum; D011083:Polycyclic Compounds; D001335:Vehicle Emissions