Effect of naloxone in a previously undescribed hypothalamic syndrome. A disorder of the endogenous opioid peptide system?
A syndrome of disordered hypothalamic function with abnormal control of temperature, appetite, and thirst, hyperprolactinaemia, and inappropriate vasopressin release is described in a 13-year-old boy who, in addition, had insensitivity to pain and a more general disorder affecting mood, sleep, and control of respiration. A disturbance of the opioid peptide system is postulated. Naloxone reversed central analgesia, altered urine fluid and electrolyte excretion, modified the hormonal response to gonadotrophin-releasing and thyrotrophin-releasing hormones, and improved the auditory and visual reaction times. Specific opioid antagonists may have a therapeutic role.
D000293:Adolescent; D001066:Appetite / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004644:Emotions / Q000187:drug effects; D004723:Endorphins / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects*; D007177:Inappropriate ADH Syndrome / Q000188:drug therapy*; D008297:Male; D009270:Naloxone / Q000627:therapeutic use*; D000699:Pain Insensitivity, Congenital / Q000188:drug therapy*; D012119:Respiration / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013577:Syndrome; D013894:Thirst / Q000187:drug effects
D004723:Endorphins; D009270:Naloxone