Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes.
The specificity repertoire of H-2Kb-specific cytolytic T lymphocytes (CTL) has been examined in B10.D2,BALB/c, and the allotype congenic line CB-20. Comparing their expression of recurrent specificities that serve as markers for the repertoire of each strain indicates that the CTL repertoire of B10.D2 (Ighb) and BALB/c (Igha) differ extensively. In contrast, the repertoires expressed by B10.D2 and CB-20 (Ighb) are essentially identical with respect to their expression of the same recurrent specificities. Taken together with results previously obtained, it is concluded that both major histocompatibility complex and Igh-linked genes affect the CTL specificity repertoire.
D000818:Animals; D002874:Chromosome Mapping; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000235:genetics; D005796:Genes; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D007143:Immunoglobulin Heavy Chains / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D000939:Epitopes; D006183:H-2 Antigens; D007143:Immunoglobulin Heavy Chains; D011948:Receptors, Antigen, T-Cell