Rapid migration of inositol phospholipids with axonally transported substances in the rabbit optic pathway.
Following an intraocular injection of myo-[2-3H]inositol, the axonal transport of labelled water-soluble substances and inositol phospholipids was investigated. Evidence was obtained for a rapid axonal transport of a relatively small amount of labelled inositol phospholipids. In contrast to other axonally transported phospholipids, there was no significant accumulation of labelled, rapidly transported inositol phospholipids in the nerve terminal region at later time intervals following the isotope administration.
D000818:Animals; D001370:Axonal Transport; D005829:Geniculate Bodies / Q000378:metabolism; D007294:Inositol / Q000378:metabolism; D009434:Neural Pathways / Q000378:metabolism; D009900:Optic Nerve / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D011817:Rabbits; D012160:Retina / Q000378:metabolism; D013477:Superior Colliculi / Q000378:metabolism
D010716:Phosphatidylinositols; D007294:Inositol