The control of globin and other eukaryotic genes.
The hypothesis is advanced that eukaryotes control different parts of their genomes by the selective use of origins of replication. Replication of a gene from an origin upstream of the gene is postulated to open it for transcription under appropriate circumstances; replication of a gene from an origin downstream of the gene closes it. The applicability of this hypothesis to the control of the human beta-globin cluster of genes is considered.
D000818:Animals; D002843:Chromatin / Q000378:metabolism / Q000648:ultrastructure; D004261:DNA Replication; D004920:Erythropoiesis; D005319:Fetal Hemoglobin / Q000235:genetics; D005786:Gene Expression Regulation; D005796:Genes; D005914:Globins / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006454:Hemoglobins / Q000235:genetics; D006657:Histones / Q000378:metabolism; D006801:Humans; D008957:Models, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic
D002843:Chromatin; D006454:Hemoglobins; D006657:Histones; D005914:Globins; D005319:Fetal Hemoglobin