Endocytosis and exocytosis: current concepts of vesicle traffic in animal cells.
Animal cells have specific pathways to transport macromolecules from their surrounding environment to their interior, and from internal compartments to the cell surface or other intracellular locations. Many of these movements appear to be receptor-dependent processes in which specific membrane receptors bind macromolecules, segregate them into discrete membrane-limited compartments, and move the molecules to new locations. Such processes include the clustering and internalization of receptor-bound ligands at the cell surface in clathrin-coated pits, the formation of endocytic vesicles (receptosomes) from coated pits, the movement of receptosomes by saltatory motion to the Golgi system, the concentration of materials in the coated pits of the Golgi system that are destined for delivery to lysosomes, and the directed traffic of materials destined for exocytosis out of the Golgi to the cell surface. This review describes some of the experiments which have led to our current understanding of the various organelles involved in this traffic and some of the biochemical mechanisms involved.
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D002966:Clathrin / Q000502:physiology; D003034:Coated Pits, Cell-Membrane / Q000502:physiology* / Q000648:ultrastructure; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000502:physiology; D011992:Endosomes / Q000502:physiology*; D005089:Exocytosis; D006056:Golgi Apparatus / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008247:Lysosomes / Q000502:physiology; D009940:Organoids / Q000502:physiology* / Q000648:ultrastructure
D002966:Clathrin; D006728:Hormones