[Noradrenaline as a RNA and Na K ATPase biosynthesis regulator in the neurons].
Noradrenaline (10(-5)M) inhibits the summary RNA synthesis in isolated neurone nuclei. In the presence of the dissolvable cytoplasmic fraction noradrenaline effect is transformed: 3H-UTP inclusion into RNA is activated. Similar results were seen in experiments with adenosine-3',5'-cyclophosphate and previously with acetylcholine. The data obtained indicate the presence of the neurone cytoplasmic factor (factors) interacting with biogenic amines and cyclic nucleotides and influencing RNA synthesis in such a complex. In the cell-free system noradrenaline inhibits Na, K-ATPase synthesis, its effect being directed at RNA synthesis inhibition upon DNA gene of Na, K-ATPase. These findings allow a conclusion that a part of neurone genes undergo noradrenaline control: the expression of several ones is activated and of the other is inhibited--the former being higher than the latter, according to noradrenaline effect on the summary RNA synthesis. Noradrenaline does not influence the glial cell RNA and DNA syntheses.
D000818:Animals; D001921:Brain / Q000166:cytology; D002467:Cell Nucleus / Q000378:metabolism*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000494:pharmacology; D003864:Depression, Chemical; D005260:Female; D006728:Hormones / Q000494:pharmacology; D009457:Neuroglia / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure*; D009638:Norepinephrine / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000096:biosynthesis*
D006728:Hormones; D012313:RNA; D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine
Noradrenalin kak reguliator sinteza RNK i Na, K-ATF-azy v nervnykh kletkakh.