Origin of amniocentesis-induced rises of alpha-fetoprotein concentrations in maternal serum.
An elevation of alpha-fetoprotein concentration in maternal serum occurred in 7 of 65 patients (11 per cent) following amniocentesis. Analysis of the molecular heterogeneity of the alpha-fetoprotein by chromatography on concanavalin A-agarose indicated that the source of the alpha-fetoprotein was fetal serum in three patients and amniotic fluid in four patients.
D000649:Amniocentesis / Q000009:adverse effects*; D000653:Amniotic Fluid / Q000032:analysis; D003208:Concanavalin A; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins; D003208:Concanavalin A