Reduction in brain serotonin synthesis rate in streptozotocin-diabetic rats.
The rate of serotonin synthesis in brain was determined in streptozotocin-diabetic and normal rats using two methods. Both the rate of 5-hydroxytryptophan accumulation after aromatic amino acid decarboxylase inhibition, and the decline rate of 5-hydroxyindole acetic acid after pargyline treatment were significantly reduced in diabetic rats. The reduced rate of synthesis may be a direct result of significantly lowered brain tryptophan levels in diabetic rats.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000096:biosynthesis*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline