The responses of isolated preparations of Bunodosoma caissarum (Correa, 1964) (Cnidaria, Anthozoa) to drugs.
Body wall strips and oral rings of Bunodosoma caissarum respond to the application of at least four categories of drugs with sustained contractions. Propionylcholine, butyrylcholine and nicotine never failed to evoke a response; acetylcholine eventually was inactive. Occasionally, a correlation between dose and response was possible. Adrenaline and noradrenaline also elicited responses, although, occasionally, both were ineffective. Tryptamine and serotonin (less) were also effective. L-Glutamate was particularly effective and its action could be depressed by GABA. Histamine, betaine, taurine and aspartate were ineffective. The results are discussed in terms of depolarization due to specific membrane receptors or to unspecific causes.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D003063:Cnidaria / Q000502:physiology*; D004837:Epinephrine / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D012615:Sea Anemones / Q000502:physiology*; D013997:Time Factors
D005971:Glutamates; D006584:Hexamethonium Compounds; D000644:Quaternary Ammonium Compounds; D010862:Pilocarpine; C017100:butyrylcholine; D018698:Glutamic Acid; D002794:Choline; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine