Increased urinary beta 2-microglobulin after cancer chemotherapy.
The serum and urinary concentrations of beta 2-microglobulin (beta 2-m) and creatinine and the urinary concentration of albumin and IgG were measured in 14 patients with hematologic malignancies before and during chemotherapy. There was a transient increase in urinary beta 2-m in nine of the 14 patients during chemotherapy. All of the nine patients but only one of the other five patients had had recent multiple chemotherapy. The urinary beta 2-m increased in 24 courses of chemotherapy given to these nine patients and was already abnormal before 13 of these courses. The increase in urinary beta 2-m was not associated with an increase in serum beta 2-m or a significant increase in urinary albumin or IgG excretion. These results suggest that chemotherapy causes a marked transient tubular proteinuria, particularly in patients who have had previous chemotherapy.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001609:Beta-Globulins / Q000652:urine*; D005260:Female; D006689:Hodgkin Disease / Q000652:urine; D006801:Humans; D007945:Leukemia, Lymphoid / Q000652:urine; D015470:Leukemia, Myeloid, Acute / Q000652:urine; D008223:Lymphoma / Q000652:urine; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000652:urine*; D009404:Nephrotic Syndrome / Q000652:urine; D011507:Proteinuria / Q000139:chemically induced; D001613:beta 2-Microglobulin / Q000652:urine*
D000970:Antineoplastic Agents; D001609:Beta-Globulins; D001613:beta 2-Microglobulin