Activation by stress of the habenulo-interpeduncular substance P neurons in the rat.
Substance P levels were significantly decreased in the ventro-tegmental area and the interpeduncular nucleus of rats submitted for 20 min to electric foot-shocks. Substance P levels in the substantia nigra and in the prefrontal cortex were not affected. These results are discussed in light of the selective activation of the mesocortico-prefrontal dopaminergic neurons induced by this stress situation.
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D008473:Median Eminence / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*; D013373:Substance P / Q000502:physiology*; D013378:Substantia Nigra / Q000502:physiology; D009435:Synaptic Transmission; D013681:Tegmentum Mesencephali / Q000502:physiology
D013373:Substance P; D004298:Dopamine