Central nervous system immunoreactive somatostatin, substance P and metenkephalin concentrations in experimental hepatic encephalopathy in the rat.
Immunoreactive somatostatin, substance P and met-enkephalin concentrations were measured in various regions of the rat brain 65 hours after portacaval shunt and compared with concentrations in sham-operated animals. No significant difference was detected in any of the three peptides in the regions studied, suggesting that these peptides do not play a role ion the pathogenesis of hepatic encephalopathy.
D000818:Animals; D001923:Brain Chemistry; D004723:Endorphins / Q000032:analysis*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000032:analysis*; D006501:Hepatic Encephalopathy / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D013004:Somatostatin / Q000032:analysis*; D013373:Substance P / Q000032:analysis*
D004723:Endorphins; D004745:Enkephalins; D013373:Substance P; D013004:Somatostatin; D004744:Enkephalin, Methionine