The histopathologic features which follow repeated applications of tobacco tar to rat lip mucosa.
The response of rat lip mucosa to two tobacco tar preparations combined with heat was examined histopathologically. It was shown that the magnitude of irritational hyperplasia produced was related to the level of irritation. This was greatest in those rats subjected to the longest period of application of the tobacco extract with the greatest concentration of tar combined with heating the site of application. Neoplastic changes were not produced.
D000818:Animals; D004848:Epithelium / Q000473:pathology; D005260:Female; D006358:Hot Temperature; D007509:Irritants; D007633:Keratins / Q000378:metabolism; D008046:Lip / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D013638:Tars; D014026:Nicotiana
D007509:Irritants; D013638:Tars; C024746:tobacco tar; D007633:Keratins