Successful control of refractory ventricular premature beat with an estrogen-progesterone compound.
Drug resistant ventricular premature contractions (VPCs) in a 35-yr-old woman were successfully controlled with a contraceptive agent containing estrogen-progesterone. The VPCs in this patient always showed an R on T phenomenon resulting in occasional short run of ventricular tachycardia. Apart from the VPCs, her ECG exhibited no abnormalities. The family history revealed 9 instances of sudden unexpected death over 3 generations. The findings of myocardial biopsy of the right ventricular endocardium were characteristic of cardiomyopathy. This report discusses the possibility that a contraceptive agent successfully suppressed VPCs in a particular woman who showed a close relation between a certain period of her menstrual cycle and the occurrence of VPCs.
D000328:Adult; D005117:Cardiac Complexes, Premature / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D009202:Cardiomyopathies / Q000150:complications / Q000473:pathology; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use*; D003645:Death, Sudden; D004562:Electrocardiography; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008598:Menstruation; D009206:Myocardium / Q000473:pathology; D011374:Progesterone / Q000008:administration & dosage*
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens; D011374:Progesterone