Mixed lymphocyte reactivity in chimpanzees. II. Family studies and identification of D locus antigens.
A large number of related chimpanzees were tested in mixed lymphocyte cultures against each other. Several similarities among the D locus products coded for by different ChLA haplotypes were observed. Six animals were found to be homozygous for D locus antigens and two of these animals carried the same D specificity. Hence, the available "typing cells" permitted the identification of five D locus antigens of the chimpanzee. So far, no linkage disequilibrium has been found between any of the D locus antigens and ChLA-A or -B locus antigens.
D000818:Animals; D002874:Chromosome Mapping; D000939:Epitopes; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006238:Haploidy; D006649:Histocompatibility Antigens / Q000235:genetics*; D006720:Homozygote; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D002679:Pan troglodytes / Q000235:genetics / Q000276:immunology*
D000939:Epitopes; D006649:Histocompatibility Antigens