The aggressive surgical management of hypercalcemia due to ectopic parathormone production.
A patient with slowly progressive metastatic renal cell carcinoma had life-threatening hypercalcemia secondary to ectopic parathormone production. Aggressive surgical debulking resulted in prolonged control of the hypercalcemia. This case illustrates the value of this surgery in the control of paraneoplastic endocrine syndromes refractory to medical management in patients with slow-growing metastatic disease.
D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D002118:Calcium / Q000378:metabolism; D005260:Female; D006729:Hormones, Ectopic / Q000096:biosynthesis*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000378:metabolism / Q000601:surgery; D007680:Kidney Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D009362:Neoplasm Metastasis; D010166:Palliative Care; D009384:Paraneoplastic Endocrine Syndromes / Q000209:etiology*; D010281:Parathyroid Hormone / Q000096:biosynthesis*; D011788:Quality of Life
D006729:Hormones, Ectopic; D010281:Parathyroid Hormone; D002118:Calcium