[Interaction of gramicidins with the cellular phospholipids of the producer Bacillus brevis].
Phospholipid fractions were isolated from the cells of Bacillus brevis var. G.-B. variants, some, of which produced gramicidin S and some did not. As was found by thin layer chromatography, phosphatidyl ethanolamine predominated in the fraction of phospholipids. Interaction of the isolated phospholipids with gramicidin S in vitro resulted in a loss of the antibiotic activity. Presumably, formation of a complex between the polypeptide and phospholipids may decrease the actual concentration of gramicidin S in cells producing the antibiotic.
D001407:Bacillus / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D004347:Drug Interactions; D006096:Gramicidin / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D008055:Lipids / Q000032:analysis; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*
D008055:Lipids; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D006096:Gramicidin
Vzaimodeĭstvie gramitsidina S s fosfolipidami kletok produtsenta Bacillus brevis.