title: Cytophotometric and morphometric studies of postnatal rat hippocampal neurons and perineuronal gliocytes after electroconvulsive shock.
abstract: Electroconvulsive shock was evoked by transcorneal electric current (50 Hz, 50 mA; 3 times by 0.2s with 10-min pauses) in 10-day and 20-day old rats. 2 hours after the end of the convulsions, the total cytoplasmic RNA and protein content per cell in CA3 hippocampal neurons has been shown cytospectrophotometrically to increase markedly in 10-day old rats without statistically significant changes in 20-day old animals. No changes in the RNA and protein content were found in perineuronal neuroglia cells in the CA3 hippocampus in both age groups of rats. Morphometric determinations revealed a pronounced augmentation of volumes of the hippocampal neuronal bodies, nuclei, and cytoplasm as well as of nucleo-cytoplasmic ratio in 10-day old rats under effect of electroconvulsive shock. In 20-day old rats, the shock led to less marked increase in volumes of the hippocampal neurons, with  no changes in nucleo-cytoplasmic ratio.
mesh_terms: D000375:Aging; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003584:Cytological Techniques; D003593:Cytoplasm / Q000648:ultrastructure; D004597:Electroshock; D005260:Female; D006624:Hippocampus / Q000166:cytology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009419:Nerve Tissue Proteins; D012313:RNA