[Evidence for the hormonal and nerve regulation of pancreatic secretion: demonstration of an enteropancreatic reflex].
The hypothesis that the pancreatic enzyme response to intestinal stimulants is mediated in part by a vagovagal enteropancreatic reflex was investigated by comparing the effect of intestinal stimulants on the innervated, intact pancreas and the denervated, autotransplanted uncinate process of the pancreas in the same dogs. Furthermore the latency for increase in pancreatic amylase secretion after intraportal injection of cholecystokinin was compared with the latency for the increase in pancreatic amylase secretion after intraduodenal injection of known stimulants of cholecystokinin release. Experiments were done with and without atropine and before and after truncal vagotomy. The results of this study provide strong evidence for the existence of an enteropancreatic reflex.
D000681:Amylases / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D005768:Gastrointestinal Hormones / Q000502:physiology*; D010179:Pancreas / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D010187:Pancreatic Hormones / Q000378:metabolism; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D005768:Gastrointestinal Hormones; D010187:Pancreatic Hormones; D001285:Atropine; D002766:Cholecystokinin; D000681:Amylases
Untersuchungen zur hormonalen und nervalen Regulation der Pankreassekretion: Nachweis eines enteropankreatischen Reflexes.