title: Hemodynamics following normovolemic hemodilution in elderly patients.
abstract: The hemodynamic effects of acute hemodilution with dextran 70 as dilutional agent were evaluated in a group of elderly patients (mean age 68, range 60-79 years) anesthetized with neurolept analgesia. The isovolemic exchange of 1.1 liter of blood (mean) with a 6% solution of dextran 70 decreased the hematocrit value from 41 to 28%. As cardiac index did not exchange, the oxygen transport capacity was significantly reduced. The main compensating mechanism for this was an increased extraction of oxygen in the tissues and, to a minor extent, a raised arterial oxygen tension. The results of this study suggest that intentional hemodilution should be used with caution in aged patients.
mesh_terms: D000368:Aged; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002404:Catheterization; D002496:Central Venous Pressure / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D005260:Female; D006438:Hemodilution; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood
chemical_list: D003911:Dextrans; D010100:Oxygen