Late-passage SC-1 cells resistant to N- and B-tropic viruses but sensitive to NB-tropic viruses.
A late-passage derivative of SC-1 cells with stable relative resistance to N- and B-tropic viruses but with retained sensitivity to NB-tropic viruses has been identified. Dual resistance was seen with the XC plaque assay, as well as reverse transcriptase assay and radioimmunoassay for viral p30. Evidence was found for resistance in clonal derivatives. These findings suggest a possible instability in determinants of cellular resistance to endogenous retroviruses and may be useful in further analysis of resistance to retrovirus infection.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D002999:Clone Cells / Q000382:microbiology; D004622:Embryo, Mammalian; D051379:Mice; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012190:Retroviridae / Q000254:growth & development*; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000032:analysis
D014764:Viral Proteins; D012194:RNA-Directed DNA Polymerase