[Palatal myoclonus associated with a decrease in 5-hydroxy-indole acetic acid in cerebrospinal fluid and responding to clonazepam].
A patient representing with palatal myoclonus was diagnosed as suffering from possible multiple sclerosis. A reduction of cerebrospinal 5-hydroxy-indole-acetic acid suggested a decreased central serotonergic turnover. A therapeutic trial with clonazepam, a serotonergic agonist, improved the myoclonus symptomatically. The possible involvement of serotonergic inhibitory systems in the expression of palatal myoclonus is discussed.
D001570:Benzodiazepinones / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis; D009132:Muscles; D009207:Myoclonus / Q000134:cerebrospinal fluid* / Q000150:complications / Q000188:drug therapy; D010156:Palatal Muscles; D014364:Tryptophan / Q000134:cerebrospinal fluid
D001570:Benzodiazepinones; D006897:Hydroxyindoleacetic Acid; D002998:Clonazepam; D014364:Tryptophan
Myoclonies du voile associées à une diminution de l'acide 5-hydroxy-indole-acétique céphalo-rachidien et répondant au clonazépam.