Progesterone-binding globulin and progesterone in guinea-pigs after ovariectomy, abortion and parturition.
The level of progesterone in the serum of pregnant guinea-pigs which continued their pregnancies after ovariectomy on Day 30 fell and then rose again. In contrast, progesterone-binding globulin (PBG) was apparently not affected. PBG did however fall in guinea-pigs which aborted and also after parturition. It is apparent therefore that high PBG levels were associated with continued pregnancy. The half life of PBG was found to be approximately 2 days.
D000022:Abortion, Spontaneous; D000510:Alpha-Globulins / Q000097:blood*; D000818:Animals; D002369:Castration; D005260:Female; D005865:Gestational Age; D006168:Guinea Pigs; D010053:Ovary / Q000502:physiology*; D049590:Postpartum Period; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011376:Progesterone-Binding Globulin / Q000097:blood*
D000510:Alpha-Globulins; D011376:Progesterone-Binding Globulin; D011374:Progesterone