Fundamental studies on a new antitumor antibiotic peplomycin.
Results of testing in mice and rats revealed that peplomycin has a stronger antitumor effect than bleomycin (BLM). Peplomycin, a BLM analogue, also has superior organ distribution characteristics and localizes in the rat prostate. Pulmonary toxicity associated with peplomycin therapy is less severe than that which accompanies BLM therapy.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism / Q000627:therapeutic use* / Q000633:toxicity; D001761:Bleomycin / Q000378:metabolism / Q000627:therapeutic use* / Q000633:toxicity; D008168:Lung / Q000187:drug effects; D051379:Mice; D017663:Peplomycin; D051381:Rats; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D017663:Peplomycin