Genetic control of antibody production to myelin basic protein in mice.
Experimental allergic encephalomyelitis (EAE) is a disease produced by inoculation of myelin basic protein (BP) into susceptible animals. Data in this report link the production of anti-BP antibody to the murine H-2 histocompatibility background. H-2k and H-2a animals produce high levels of anti-BP antibodies as measuring during both primary and secondary immune responses. Strains with H-2b,d,p,q,s haplotypes are poor responders after primary immunization; however some H-2s and H-2d animals showed an increase in antibody after boosting. The use of M. tuberculosis instead of M. butyricum resulted in greater antibody production in H-2d strains. The response observed in 4 congenic pairs of mice support the association between antibody formation and the H-2 complex. Experiments with recombination inbred strains indicate that responsible genes reside in the I-A region of the H-2 complex.
D000818:Animals; D000917:Antibody Formation; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D004676:Myelin Basic Protein / Q000276:immunology*; D011863:Radioimmunoassay; D051381:Rats; D013045:Species Specificity
D006183:H-2 Antigens; D004676:Myelin Basic Protein