Persistence of dihydrotestosterone inhibition of lordosis in estrogen-primed rats fed a tryptophan-deficient diet.
Administering increasing dosages of 5alpha-dihydrotestosterone propionate (DHTP) (0, 40, or 80 microgram/100 g in oil daily) to ovariectomized female rats treated concurrently with estradiol benzoate (EB) (1 microgram/100 g in oil daily) caused significant, equivalent reduction in lordotic responsiveness in rats maintained either on a tryptophan-deficient corn diet or on a corn diet to which L-tryptophan was added. Whole brain concentrations of 5-hydroxytryptamine (5-HT) and of 5-hydroxyindoleacetic acid were approximately two times higher in rats fed corn+tryptophan versus corn alone. These findings suggest that the ability of DHTP to inhibit lordosis probably depends upon some mechanism other than a facilitation of 5HT release from serotonergic neurons.
D000818:Animals; D001921:Brain / Q000378:metabolism; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014364:Tryptophan / Q000172:deficiency*
D013196:Dihydrotestosterone; D012701:Serotonin; D011374:Progesterone; D004958:Estradiol; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan