[Synthesis of alpha-fetoprotein in rat liver after a single injection of the liver carcinogen 4-dimethylaminoazobenzene and its noncarcinogenic isomer 4-diethylaminoazobenzene].
Single injection of the hepatospecific carcinogen 4-dimethylaminobenzene and its noncarcinogenic isomer 4-dimethylaminoazobenzene induced the foci of oval and transitional cells in the rat liver. Part of the cells synthesized alpha-fetoprotein. It is suggested that induction of the foci of the above cells and alpha-fetoprotein synthesis are likely to be due to the toxic effect of the two carcinogenic agents.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D005455:Fluorescent Antibody Technique; D007536:Isomerism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D000509:alpha-Fetoproteins / Q000096:biosynthesis*; D004124:p-Dimethylaminoazobenzene / Q000494:pharmacology*
D001551:Benz(a)Anthracenes; D000509:alpha-Fetoproteins; D015127:9,10-Dimethyl-1,2-benzanthracene; D004124:p-Dimethylaminoazobenzene
Sintez alpha-fetoproteina v pecheni krys posle odnokratnoi in"ektsii gepatokantserogena 4-dimetilaminoazobenzola i ego nekantserogennogo izomera 4-dietilaminoazobenzola.