title: [Effect of mitogens on suppression of antibody formation and proliferation in dense cultures].
abstract: A study was made of the effect of mitogens on general proliferation and primary immune response to sheep red blood cells in density-inhibited cultures of mouse spleen cells. The mitogens applied included fetal calf serum and both B cell- and T cell-specific mitogens (dextran sulfate, LPS and ConA). Experiments with 3H-thymidine incorporation demonstrated that the proliferation was equally enhanced by any mitogen in both optimal and density-inhibited cultures. The mitogens did not remove the density inhibition of antibody formation.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology; D004926:Escherichia coli / Q000032:analysis; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008934:Mitogens / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D013154:Spleen / Q000187:drug effects*
chemical_list: D003911:Dextrans; D008070:Lipopolysaccharides; D008934:Mitogens; D003208:Concanavalin A; D016264:Dextran Sulfate
vernacular_title: Vliianie mitogenov na podavlenie antiteloobrazovaniia i proliferatsii v plotnykh kul'turakh.