title: Clonal inheritance of rRNA gene activity: cytological evidence in human cells.
abstract: Clone-specific silver staining patterns of the nucleolus organizers (NOs) were observed in clones deriving from a human diploid fibroblast culture. Each specific staining pattern corresponds to one of the nine patterns observed in the general population. Since silver stainability of the NOs is related to rRNA gene function, these data demonstrate the clonal inheritance of rRNA gene activity.
mesh_terms: D002478:Cells, Cultured; D002871:Chromosome Banding; D002877:Chromosomes, Human / Q000648:ultrastructure*; D002999:Clone Cells / Q000648:ultrastructure; D005260:Female; D005796:Genes; D006801:Humans; D007621:Karyotyping; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D012335:RNA, Ribosomal / Q000235:genetics*; D012834:Silver; D012867:Skin / Q000166:cytology; D013194:Staining and Labeling
chemical_list: D012335:RNA, Ribosomal; D012834:Silver