[Effect of sodium selenite, vitamin E, retabolil and their combination on the ATP, creatine phosphate and inorganic phosphorus content of organs of rats of different ages in the "aurantin" model of hypotrophy].
The effect of sodium selenite, vitamin E, retabolil and their combinations on the content of ATP, creatine phosphate (CP) and inorganic phosphorus in the liver and skeletal muscle was studied in 3 groups of white rats (one- and two-month old and adults). Sodium selenite (30 micrograms/kg), vitamin E (50 mg/kg), retabolil (4 mg/kg) and their combination administered in a single subcutaneous dose for 14 days increased the content of ATP, CP and inorganic phosphorus in the liver and skeletal muscle after these parameters had decreased because of aurantine administration (50 micrograms/kg). Combined use of sodium selenite, vitamin E and retabolil appeared to be most efficacious.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000375:Aging / Q000187:drug effects*; D045930:Anabolic Agents / Q000627:therapeutic use*; D000818:Animals; D003609:Dactinomycin; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D010725:Phosphocreatine / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
D045930:Anabolic Agents; D005419:Flavonoids; D010725:Phosphocreatine; D014810:Vitamin E; D003609:Dactinomycin; D010758:Phosphorus; C090194:aurantin; D009277:Nandrolone; D000255:Adenosine Triphosphate; D020887:Selenious Acid; D000077603:Nandrolone Decanoate; D012643:Selenium
Vliianie selenita natriia, vitamina E, retabolila i ikh kombinatsii na soderzhanie ATF, kreatinfosfata i neorganicheskogo fosfora v organakh krys raznogo vozrasta pri "aurantinovoĭ" modeli gipotrofii.