[Value of the determination of beta-2-microglobulin in the monitoring of myeloma. Apropos of 290 determinations].
The authors first established a correlation between serum 2 microglobulin (beta 2 m) and creatinine (beta 2m) mg/1) = 0.033 X creatinine (mumol/l) + 0.236) in order to be able to calculate the ratio of measured theoretical beta 2 m, as a function of cell production only. Comparison of this ratio with total tumour mass. calculated according to Durie and Salmon, for 290 estimations, gave a very significant correlation (r = 0.31; p less than 0.0001). This correlation was also significant for the 70 estimations made in cases of myelomas with little or no secretion (7 light chain, 1 non-secreting, 1 IgD and 1 IgM) where the estimation is of the greatest importance as an indication of the course.
D001609:Beta-Globulins / Q000032:analysis*; D003404:Creatinine / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D009367:Neoplasm Staging; D001613:beta 2-Microglobulin / Q000032:analysis*
D001609:Beta-Globulins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D001613:beta 2-Microglobulin; D003404:Creatinine
Intérêt du dosage de la bêta-2-microglobuline dans la surveillance des myélomes. A propos de 290 dosages.