[N-nitrososarcosine formation from predecessors in the body].
A method has been developed for isolation and analysis of the non-volatile carcinogen N-nitrososarcosine in different media. It has been found that in aqueous solution and gastric juice of the dog, N-nitrososarcozine is formed in an acid medium, with maximum yield being attained at pH 3 and at an equal molar ratio of the precursors. Endogenous formation of the carcinogen in the rat stomach has been studied.
D000818:Animals; D004285:Dogs; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D009602:Nitrosamines / Q000096:biosynthesis*; D051381:Rats; D012521:Sarcosine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D012977:Sodium Nitrite / Q000378:metabolism; D012996:Solutions
D009602:Nitrosamines; D012996:Solutions; C013162:N-nitrososarcosine; D012977:Sodium Nitrite; D012521:Sarcosine
Obrazovanie N-nitrozosarkozina iz predshestvennikov v organizme.