[Action of human leukocyte interferon on poliomyelitis virus reproduction in resistant MIO(r) cells].
The effect of human leukocyte interferon on reproduction of poliomyelitis virus in MIO cells resistant to this virus (MIOr) and sensitive MIO cells was studied. Interferon was shown to exert a short-time protective effect in the sensitive cells and to induce virus reproduction in the resistant cells. It is suggested that poliomyelitis virus reproduction in the resistant cells is due to activation of lysosomal enzyme, cathepsin D, in this system.
D002403:Cathepsins / Q000378:metabolism; D004352:Drug Resistance, Microbial; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007962:Leukocytes / Q000276:immunology*; D008247:Lysosomes / Q000201:enzymology; D017955:Poliovirus / Q000187:drug effects*; D013997:Time Factors; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D007372:Interferons; D002403:Cathepsins
Deistvie chelovecheskogo leĭkotsitarnogo interferona na reproduktsiiu virusa poliomielita v rezistentnykh kletkakh MIO(r).