Absence of L-histidine lyase and histidine imidazole metabolites in human adenomatous prostate.
The histidine metabolism in homogenates of human tissues of nontreated benign prostatic hyperplasia has been examined by means of the determination of L-histidine ammonia lyase activity (EC 4.3.1.3;histidine alpha-deaminase, histidase) and the histidine imidazole metabolites which were separated by means of ion exchange chromatography. Neither enzymatic activity nor metabolites of histidine could be detected. It is concluded that non-treated benign prostatic hyperplasia lacks L-histidine ammonia lyase activity and subsequently the metabolic pathway of histidine.
D000642:Ammonia-Lyases / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism*; D006638:Histidine Ammonia-Lyase / Q000378:metabolism*; D006801:Humans; D007093:Imidazoles / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000601:surgery
D007093:Imidazoles; D006639:Histidine; D000642:Ammonia-Lyases; D006638:Histidine Ammonia-Lyase