Beta 2-adrenoceptor agonists reverse the leukotriene C4-induced release response of macrophages.
The experiments concerned the effects of beta-adrenoceptor agonists and antagonists on the leukotriene-C4 (LTC4)-induced secretory release response from carrageenan-elicited rat peritoneal macrophages. Both the non-selective beta-adrenoceptor agonist isoprenaline and the selective beta 2-adrenoceptor agonist salbutamol reversed the LTC4-induced release response. Addition of the non-selective beta-adrenoceptor antagonist sotalol or the beta 2-selective antagonist H3525 abolished these effects. Practolol, a selective beta 1-adrenoceptor antagonist was without any effect on the isoprenaline-LTC4 interaction. These results are consistent with the presence of beta 2-adrenoceptors on macrophages. The results of this study are discussed in view of a possible, cyclic adenosine 3'5'-monophosphate (cAMP)-mediated interaction between prostaglandin E2 and LTC4 in modulating macrophage function.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D004809:Ephedrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005966:Glucuronidase / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D008247:Lysosomes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D010537:Peritoneum / Q000187:drug effects*; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013015:Sotalol / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D011458:Prostaglandins E; D013189:SRS-A; C004380:H 35-25; D013929:Thromboxane B2; D013015:Sotalol; D005966:Glucuronidase; D004809:Ephedrine; D007545:Isoproterenol; D000420:Albuterol