Effect of aldehydes on polyamine metabolism. II. Methylglyoxal-induced changes in S-adenosylmethionine decarboxylase (SAMD) activity and RNA synthesis and degradation in isolated hepatocytes.
In isolated rat liver cells methylglyoxal (MeG) inhibits S-adenosylmethionine decarboxylase activity and RNA and protein synthesis; MeG also stimulated RNA degradation. The changes induced by MeG in RNA metabolism are partially prevented (in the case of RNA synthesis inhibition) or totally abolished (in the case of RNA degradation stimulation) by exogenous spermidine addition. This suggests the effects of MeG on RNA metabolism are dependent, at least in part, on SAMD inhibition.
D012437:Adenosylmethionine Decarboxylase / Q000037:antagonists & inhibitors*; D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D009963:Orotic Acid / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D011700:Putrescine / Q000378:metabolism*; D011765:Pyruvaldehyde / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D013095:Spermidine / Q000494:pharmacology
D000447:Aldehydes; D011506:Proteins; D009963:Orotic Acid; D012313:RNA; D011765:Pyruvaldehyde; D002262:Carboxy-Lyases; D012437:Adenosylmethionine Decarboxylase; D013095:Spermidine; D011700:Putrescine