[Synthesis of oligosaccharide determinants with amide spacers of T-type antigens].
The hapten of the T-antigen was synthesized with a peptide-like amide-spacer as 2-(4-methoxycarbonylbutanecarboxamido)ethyl 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside and coupled with serum albumin to give a synthetic antigen. Other O-beta-D-galactopyranosyl haptens, 2-(4-methoxycarbonylbutanecarboxamido)ethyl 2-acetamido-2-deoxy-4-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside, O-beta-D-galactopyranosyl-(1 leads to 3)-O-[beta-D-galactopyranosyl-(1 leads to 4)]-2-acetamido-2-deoxy-alpha-D-galactopyranoside, and 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside, the last compound being the determinant of the Lewis Lec antigen, were also synthesized.
D000577:Amides; D000955:Antigens, T-Independent; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D000939:Epitopes; D006241:Haptens; D007202:Indicators and Reagents; D008722:Methods; D009844:Oligosaccharides / Q000138:chemical synthesis*
D000577:Amides; D000955:Antigens, T-Independent; D000939:Epitopes; D006241:Haptens; D007202:Indicators and Reagents; D009844:Oligosaccharides
Synthese von Oligosaccharid-Determinanten mit Amidspacer vom Typ des T-Antigens.