Identification of Anaplasmataceae (Haemobartonella) antigen and antibodies in systemic lupus erythematosus.
Free antigen related to Anaplasma marginale (AM) (Haemobartonella) was demonstrated in the glomeruli of one patient with lupus nephritis. Indirect fluorescent antibodies against this rickettsia were demonstrated in all of 22 lupus sera tested, with titers ranging from 1:20 to 1:1280. Geometric mean titer (GMT) was 116. Fifty-eight percent of 102 controls did not react to AM by indirect fluorescent antibody technique, and GMT of all controls was 10.7 Immunofluorescence was eliminated by neutralization and blocking techniques.
D000328:Adult; D000710:Anaplasmataceae / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D002417:Cattle; D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000276:immunology*; D005719:gamma-Globulins / Q000096:biosynthesis
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D005719:gamma-Globulins