The role of the substantia nigra in the control of amygdaloid paroxysmal activity.
Both in acute and chronic cats focal paroxysmal activity evoked in the ventro-basal complex of the amygdala has been inhibited by substantia nigra conditioning stimulation, to a greater extent, than by caudate nucleus activation. Injection of kainic acid into substantia nigra resulted in the disappearance of the caudate inhibition. It is suggested that the final control, exerted by the striatum on the amygdaloid seizures, occurs by means of the substantia nigra.
D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000503:physiopathology; D004597:Electroshock; D007608:Kainic Acid; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013378:Substantia Nigra / Q000503:physiopathology*
D007608:Kainic Acid