[Molecular bases for the action of etimizol].
Experiments on rats were made to study the molecular mechanism of the action of a new original neurotropic drug etimizol administered in a dose of 10-25 mg/kg. It was shown that it activates brain cAMP, increases the concentration of Ca2+ and membrane permeability of brain synaptosomes. The drug was also shown to enhance genome activity of the brain cells and to intensity energy metabolism. It is concluded that the molecular mechanism of etimizol action is related to the activation of the adenyl cyclase system and to the increased cAMP content, thereby leading to the activation of gene transcription, intensification of metabolic processes, and to the increased synaptic conduction.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005042:Etimizol / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013268:Stimulation, Chemical; D013574:Synaptosomes / Q000187:drug effects
D007093:Imidazoles; D012313:RNA; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases; D005042:Etimizol; D002118:Calcium
Molekuliaryne osnovy deĭstviia étimizola.