Circulating antithrombins in pregnancy.
In a cross-sectional study circulating levels of antithrombins, antithrombin III, alpha 1-antitrypsin and alpha 2-macroglobulin were measured in groups of 20 women before pregnancy, during each trimester and post partum. Blood levels of antithrombin III were significantly lower, alpha 1-antitrypsin higher and alpha 2-macroglobulin no different when compared with those of the non-pregnant and puerperal states. These findings suggest that there may be not only an increase in total antithrombin production, but also a qualitative change in antithrombin 'activity', the principal protein during pregnancy being alpha 1-antitrypsin.
D000510:Alpha-Globulins / Q000032:analysis*; D000990:Antithrombin III / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000510:Alpha-Globulins; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D000990:Antithrombin III