Subchronic toxicity of photomirex in the female rat: results of 28- and 90-day feeding studies.
Photomirex (8-monohydromirex) was administered to female Sprague-Dawley rats at dietary levels of 0.2, 1.0, 5.0, 25.0 and 125 ppm. Food intake and body weight gain were significantly depressed at the 125 ppm level in the 28- but not in the 90-day study. Significant alterations were observed in some hematological and biochemical parameters at the highest dietary level in the 90-day study. Photomirex residues accumulated in a dose-dependent manner in perirenal fat, liver, brain, kidney, and spleen. Dose-dependent histotoxic effects were observed in liver and thyroid at and above 1 ppm; hepatomegaly was observed at 25.0 and 125 ppm. These results indicate that photomirex was approximately five times more toxic than mirex in terms of liver histology. When these results are compared with those observed in an earlier study in the male rat, it is evident that the female is less susceptible to photomirex than the male.
D000273:Adipose Tissue / Q000473:pathology; D000815:Aniline Hydroxylase / Q000032:analysis; D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000473:pathology; D007631:Chlordecone / Q000633:toxicity; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D005836:Genitalia, Female / Q000473:pathology; D006403:Hematologic Tests; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008917:Mirex / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity*; D009026:Mortality; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012737:Sex Factors; D013961:Thyroid Gland / Q000473:pathology; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014018:Tissue Distribution
D004785:Environmental Pollutants; D007306:Insecticides; C016665:photomirex; D002784:Cholesterol; D000815:Aniline Hydroxylase; D013974:Thyroxine; D007631:Chlordecone; D008917:Mirex