Abnormal serum alpha 2-macroglobulin in Dyggve-Melchior-Clausen syndrome.
The high levels of alpha 2-macroglobulin found in the serum of three patients suffering from Dyggve-Melchior-Clausen syndrome, an autosomal recessive metabolic disorder, resembling mucopolysaccharidoses, have been further characterised by crossed immunoelectrophoresis. The immunoprecipitate of patients' alpha 2-macroglobulin forms a double arc, this may be helpful in the diagnosis of the syndrome.
D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D008607:Intellectual Disability / Q000097:blood; D009083:Mucopolysaccharidoses / Q000097:blood*; D013577:Syndrome; D000511:alpha-Macroglobulins / Q000032:analysis*
D000511:alpha-Macroglobulins