Efficient removal of abnormal immunoglobulin G from plasma of a multiple myeloma patient. Description of a new method for treatment of the hyperviscosity syndrome.
Patients with multiple myeloma who have complications secondary to hyperviscosity are treated by chemotherapy and/or plasmapheresis. Because the response to chemotherapy is usually delayed, plasmapheresis is required for the removal of larger concentrations of plasma proteins to avoid life-threatening complications. Until now there has been no available means to decrease the abnormal plasma proteins in a selective manner. This report describes a new method for the selective removal of immunoglobulin G from the plasma of a patient suffering from IgG-type multiple myeloma. Results obtained from plasmapheresis and selective immunoadsorption of IgG are compared. It appears that the technique described herein may offer a new, more efficient method for the palliative treatment of diseases associated with elevated concentrations of plasma immunoglobulin G.
D000328:Adult; D001809:Blood Viscosity; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D007163:Immunosorbent Techniques; D009101:Multiple Myeloma / Q000097:blood*; D010166:Palliative Care; D010956:Plasmapheresis; D013211:Staphylococcus aureus / Q000276:immunology
D007074:Immunoglobulin G