title: [RNA synthesis in rat brain during pharmacological modification of norepinephrine metabolism].
abstract: Norepinephrine metabolism and nuclear RNA (nRNA) synthesis in the rat brain are found to be conjugated. Under the effect of preparations inducing a disturbance in the norepinephrine (sodium diethyldithiocarbamate and reserpine) its content in the brain tissue lowers and the nRNA synthesis intensity decreases. Accumulation on total resources of norepinephrine in the brain under the effect of ipraside or its synaptic form (melipramine, Lu-5) intensifies the nRNA synthesis.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D004050:Ditiocarb / Q000494:pharmacology; D007099:Imipramine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
chemical_list: D012313:RNA; D012110:Reserpine; D004050:Ditiocarb; D007099:Imipramine; D009638:Norepinephrine
vernacular_title: Sintez RNK v golovnom mozge krys pri farmakologischeskikh vozdeĭstviiakh na obmen noradrenalina.