Potentiation of antitumor effect of virus-induced interferon by mouse immune interferon preparations.
In inbred DBA/2 mice, the antitumor activities of separate and combined preparations of mouse immune interferon and mouse virus-induced interferon on the development of P388 tumors were studied. Immune interferon alone (25 U/day) did not affect tumor development. Virus-induced interferon alone (25,000 U/day) delayed tumor development and increased survival time. The mouse immune interferon preparations significantly enhanced or potentiated the antitumor effects of mouse virus-induced interferon when the interferons were used in combined therapy.
D000818:Animals; D004768:Enterotoxins / Q000276:immunology; D005260:Female; D007369:Interferon Inducers; D007372:Interferons / Q000276:immunology / Q000627:therapeutic use*; D007941:Leukemia P388 / Q000401:mortality / Q000628:therapy*; D007942:Leukemia, Experimental / Q000628:therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D009522:Newcastle disease virus; D013210:Staphylococcus / Q000276:immunology
D004768:Enterotoxins; D007369:Interferon Inducers; D007372:Interferons