[Interferon as a protector in human cells treated with 4-nitroquinoline-1-oxide].
Interferon having the activity 25-37 and 375 IU/ml decreases the frequency of chromosome aberrations induced with the cancerogen 4-nitroquinoline-1-oxide in diploid human cells. The protective effect of interferon is not connected with stimulation or inhibition of cell division. It has been revealed that interferon with the activity 25-37 IU/ml has a stimulating effect on mitotic activity of cells, while interferon with the activity 375 IU/ml inhibits cell division.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004171:Diploidy; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D009600:Nitroquinolines / Q000494:pharmacology*
D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide; D007372:Interferons
Izuchenie interferona kak protektora v kletkakh cheloveka, obrabotannykh 4-nitrokinolin-1-oksidom.