Antigen sharing between Fasciola hepatica and human erythrocytes.
Several lyophilized bovine and ovine liver flukes (Fasciola hepatica) extracts were examined for the presence of blood group like antigens using an automated haemagglutination inhibition procedure. This sensitive method allowed the detection of A, B, H. Lea, Leb, P1, and Pk group specific substances. Their immunogenicity was confirmed in anti-Fasciola hyperimmunized rabbits. Immunofluorescent probes showed that these substances are located on cell membranes of the tegumental syncytium and caeca epithelium cells of the fluke. These data were discussed along with current concepts concerning, the origin, the consequences ant the biological significance of the occurrence of blood group like substances in parasites.
D000017:ABO Blood-Group System / Q000276:immunology; D000818:Animals; D001789:Blood Group Antigens / Q000276:immunology*; D000939:Epitopes; D004910:Erythrocyte Membrane / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005210:Fasciola hepatica / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology; D010127:P Blood-Group System / Q000276:immunology
D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D000939:Epitopes; D007983:Lewis Blood Group Antigens; D010127:P Blood-Group System