Effect of beta-blocking drugs on peripheral blood flow in intermittent claudication.
To determine the possible effects of beta-adrenergic blocking drugs on blood flow in arteriosclerotic peripheral vascular disease, we have measured muscle blood flow in eight patients with intermittent claudication who were taking beta-blocking drugs for mild uncomplicated hypertension. Patients completed daily, pindolol 5 mg three times daily, atenolol 100 mg daily, or placebo. Mean exercise muscle blood flow fell by approximately 30% after each active drug when compared to placebo. beta-Blocking drugs may be contraindicated in the presence of peripheral vascular disease. Cardioselectivity and partial agonist activity appear to confer no advantages in such patients.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000368:Aged; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply; D012039:Regional Blood Flow / Q000187:drug effects
D000319:Adrenergic beta-Antagonists