Properties of an encephalitogenic canine parainfluenza virus.
An isolate of canine parainfluenza (CPI) virus from the cerebrospinal fluid of a dog with neurological dysfunction was characterized in vitro in comparison to a prototype strain of CPI virus, D008. The virus, designated 78-238 was found to be antigenically related to CPI virus (Manhatten strain) and simian virus 5 (SV5), but not to mumps virus (Enders strain). Ultrastructural observation of gradient-purified 78-238 virus revealed enveloped pleomorphic virions with helical nucleocapsid symmetry. Preliminary pathological studies indicated that 78-238 virus was encephalitogenic for gnotobiotic dogs when inoculated by the intracerebral route.
D000818:Animals; D004285:Dogs; D004660:Encephalitis / Q000134:cerebrospinal fluid* / Q000150:complications; D000939:Epitopes; D008854:Microscopy, Electron; D009109:Mumps virus / Q000276:immunology; D018184:Paramyxoviridae Infections / Q000134:cerebrospinal fluid* / Q000150:complications; D018108:Respirovirus / Q000276:immunology* / Q000472:pathogenicity / Q000648:ultrastructure
D000939:Epitopes