A strain survey of age-dependent changes in antigen elimination, antibody formation and tolerance.
A strain survey has been undertaken to examine polymorphism of age-dependent changes in antigen elimination, immune responsiveness and tolerance inducibility. In young mice of tested strains, other than C57BL/6J, aggregate-freed mouse Ig was eliminated faster than was the xenogeneic Ig(RGG); C57BL/6J was the only exception. The rate of elimination increased with age in all strains, tested. Antibody formation to RGG decreased in 3 (BALB/cJ, 129/J, DBA/2J) out of the eleven strains tested at 5--7 and 31--40 weeks of age; there was a considerable strain variation in the extent of this decrease. Age-dependent resistance to tolerance induction was observed in a fraction of animals of H-2 haplotypes, H-2k and H-2d.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D005260:Female; D007108:Immune Tolerance; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010447:Peptide Hydrolases / Q000096:biosynthesis; D011817:Rabbits; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D005719:gamma-Globulins / Q000276:immunology
D000941:Antigens; D005719:gamma-Globulins; D010447:Peptide Hydrolases