Elevated glycosyltransferase activities in infected or traumatized hosts: nonspecific response to inflammation.
Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver during inflammatory processes. Serum sialyltransferase became elevated in bacteria-infected or burned rats and sandfly fever-infected humans, but did not correlate with acute-phase serum protein changes. These data suggest that nonparenchymal liver cells, such as macrophages, may contribute substantially to elevated sialyltransferase activity in the circulation during infection and, as such, represent a general host response to infection and tissue trauma.
D000117:Acetylglucosamine / Q000378:metabolism; D000818:Animals; D002056:Burns / Q000201:enzymology*; D005647:Fucosyltransferases / Q000378:metabolism; D005700:Galactosyltransferases / Q000378:metabolism; D005964:Glucosyltransferases / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008297:Male; D017351:N-Acetylglucosaminyltransferases; D010217:Phlebotomus Fever / Q000201:enzymology*; D011008:Pneumococcal Infections / Q000201:enzymology*; D051381:Rats; D012799:Sialyltransferases / Q000378:metabolism; D014166:Transferases / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism
D000511:alpha-Macroglobulins; D014166:Transferases; D005647:Fucosyltransferases; D005700:Galactosyltransferases; D005964:Glucosyltransferases; D017351:N-Acetylglucosaminyltransferases; C037649:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase; D012799:Sialyltransferases; D000117:Acetylglucosamine