Further immunological studies on components of the kallikrein-kinin system. Immunomodulatory effect in mice.
Porcine pancreatic kallikrein and synthetic bradykinin usually applied for stimulation of sperm motility were administered in mice to study their effect on the immune response. Humoral immune response was recorded by the number of direct plaque-forming cells in spleen-cell suspension, and the cell-mediated immune response was determined by the survival rate of allogeneic skin grafts. Kallikrein exerted suppressive influence both on the primary and on the secondary humoral immune response accompanied by well-expressed splenomegaly but bradykinin stimulated the humoral immune response. Both substances did not affect the cell-mediated immune response.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology*; D005260:Female; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular / Q000187:drug effects*; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016038:Skin Transplantation; D013163:Splenomegaly / Q000139:chemically induced
D007610:Kallikreins; D001920:Bradykinin