The action of thallium acetate on spontaneous transmitter release in the rat neuromuscular junction.
Frequencies and amplitudes of miniature endplate potentials (MEPP's) were recorded from neuromuscular junctions of the rat phrenic nerve-diaphragm preparation in vitro. Superfusion of the preparations with Ringer solution containing thallium acetate (Tlac) gradually increased the frequency of MEPP's by a factor of 10 within 30 min (1 X 10(-3) mol/l Tlac) and 180 min (5 X 10(-4) mol/l Tlac), whereas the amplitude of MEPP's remained unchanged. Frequency of MEPP's fitted a Poisson-distribution which persisted during superfusion with Tl+-Ringer. Sub-MEPP amplitudes remained unaffected by the action of thallium. It is concluded that thallium interferes presynaptically with spontaneous transmitter release.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009942:Organometallic Compounds; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D013793:Thallium / Q000633:toxicity*
D018377:Neurotransmitter Agents; D009942:Organometallic Compounds; D013793:Thallium; D008274:Magnesium; C026995:thallium acetate; D011188:Potassium