Use of the macrophage migration inhibition test to evaluate antigenic differences in golden hamster transplantable melanomas.
Macrophage migration inhibition test in the presence of melanotic and amelanotic melanoma cells was analyzed by means of signal detection theory reasoning. The cellular immune response as measured by MMI test was stronger in hamsters grafted with amelanotic melanoma. A statistical analysis indicated that the amelanotic melanoma antigenic strength was greater than that of its melanotic counterpart.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002464:Cell Migration Inhibition; D006224:Cricetinae; D000939:Epitopes; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008545:Melanoma / Q000276:immunology*; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D013154:Spleen / Q000166:cytology
D000951:Antigens, Neoplasm; D000939:Epitopes