[Results of artificial immunization of Rh-negative persons for the production of anti-D(RhO)-antibodies].
By means of a recording sheet the data about 62 artificially immunised male persons are evaluated retrospectively. 51 of them (82.3%) were anti-D-antibodies, with 41 of them having a high titer sufficient for gaining plasma. 2/3 of all test persons formed an accompanying antibody anti-C. In order to avoid this, persons of Rh-formula Cde may be included into artificial immunisation. An anti-E as an accompanying antibody was found in 2/3 of those test persons who had received injections of cDE blood. The blood of this Rh-formula will yield better immunising results than cDe blood. It was only in three immunised persons (4.8%) that side effects with a light or medium course of seriousness could be observed. It is necessary to develop immunobiological investigation methods to recognize those persons prior to the arteficial immunisation, who are suitable or unsuitable for anti-D-antibody formation.
D000328:Adult; D000917:Antibody Formation; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007114:Immunization; D007231:Infant, Newborn; D007518:Isoantibodies; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System
Ergebnisse der artefiziellen Immunisierung Rh-negativer Personen zur Erzeugung von Anti-D(Rh0)-Antikörpern.