Regional fibrinolytic study in coronary artery disease.
In a group of coronary patients studies of fibrinolysis were carried out during cardiac bilateral catheterization. The following tests were evaluated: Euglobulin lysis time, fibrinogen, plasminogen, AT III, alpha 1-antitrypsin and alpha 2-macroglobulin. Fibrinolytic activity was reduced in various cardiac chambers. Plasminogen levels were elevated probably because of reduced utilization or consumption. Alpha 1-antitrypsin and alpha 2-macroglobulin levels were greatly reduced both in the arterial and in the venous system. From these results the fibrinolytic system may be concluded to be defective in coronary patients.
D000328:Adult; D000991:Antithrombins / Q000032:analysis; D001013:Aorta, Thoracic; D001800:Blood Specimen Collection; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D006325:Heart Atria; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis; D011651:Pulmonary Artery; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000991:Antithrombins; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D005340:Fibrinogen; D010958:Plasminogen