Active secretion of bicarbonate by rabbit colon.
A serosa-mucosa movement of bicarbonate against concentration gradient was detected at this intestinal level. This movement is partially dependent on oxidative phosphorylation since it is abolished by DNP administration, but as it is not affected by acetazolamide administration it can be supposed as dependent on carbonic anhydrase activity.
D019297:2,4-Dinitrophenol; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D003106:Colon / Q000187:drug effects / Q000502:physiology*; D004140:Dinitrophenols / Q000494:pharmacology; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010085:Oxidative Phosphorylation; D011817:Rabbits
D001639:Bicarbonates; D004140:Dinitrophenols; D004573:Electrolytes; D019297:2,4-Dinitrophenol