Therapeutic effect of bleomycin on experimental infection of mice with Trypanosoma gambiense and Trypanosoma evansi.
Intraperitoneal injection of 10 mg/Kg bleomycin into mice 24 h after inoculation with Trypanosoma gambiense or Trypanosoma evansi, reduced the incidence of infection 62.1%, and 95.2%, respectively. No parasitemia was not found in these mice. Treatment of mice with parasitemia with 30 mg/Kg of bleomycin decreased the number of parasites within about 5 h and caused complete cure without relapse in 45% and 75% of mice infected with T. gambiense and T. evansi, respectively. Treatment of mice infected with T. gambiense with bleomycin in combination with ethidium bromide was highly effective and resulted in a high incidence of complete cure, even in heavily infected mice. The mode of action of bleomycin and ethidium bromide on trypanosomes in relation to p-rosaniline resistance is discussed.
D000818:Animals; D001761:Bleomycin / Q000627:therapeutic use*; D004351:Drug Resistance; D004996:Ethidium / Q000627:therapeutic use; D051379:Mice; D012394:Rosaniline Dyes / Q000494:pharmacology; D014345:Trypanosoma / Q000187:drug effects; D014347:Trypanosoma brucei gambiense; D014352:Trypanosomiasis / Q000188:drug therapy*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D012394:Rosaniline Dyes; D001761:Bleomycin; C025485:basic fuchsin; D004996:Ethidium