On the prevention of haematogenous tumour metastasis to liver and lung.
Vascular endothelium is lined by a layer of alpha, 2, macroglobulin (AMG). This protide is believed to regulate the rate of extravasation of tumor cells. Experiments are described which show that increasing the deposition of AMG (enhancing its production and blocking its lysis) reduces the incidence of tumour metastases to liver and lung.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D005260:Female; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008297:Male; D009374:Neoplasms, Experimental / Q000473:pathology; D009360:Neoplastic Cells, Circulating; D051381:Rats; D000511:alpha-Macroglobulins / Q000378:metabolism*
D000511:alpha-Macroglobulins; D007611:Aprotinin