Specific and non-specific multiple unit activities during pentylenetetrazol seizures. I. Animals with 'encéphale isolé'.
The present report describes the sequence of activation and deactivation of multiple unit activities (MUA) in the brain stem reticular formation and pyramidal tract, in relation to the clinical seizure and electroencephalographic and electromyographic tonic-clonic discharges induced by pentylenetetrazol (PTZ), in cats immobilized by high spinal transection ('encéphale isolé'). Threshold doses of PTZ (20 mg/kg i.v.) produced the following events: (1) Significant increase in mesencephalic and pontine MUA, anticipating 2 (+/- 1) sec the clinical and electromyographic seizures and 5 (+/- 2) sec the onset of EEG and pyramidal tract tonic-clonic discharges. (2) A further increase in mesencephalic and pontine reticular MUA and electromyogram MUA at the onset of EEG and pyramidal tract tonic-clonic discharges. (3) Significant decrease of EEG spike activity and pyramidal tract MUA to levels below the control period 16 (+/- 8) sec later, while mesencephalic and pontine MUA and electromyogram remained very high. Results suggest that (i) PTZ-induced seizures start in the brain stem reticular formation and propagate to muscles by at least two different pathways: a pyramidal and an extrapyramidal pathway; (ii) that inhibition of seizure activity may start at the cortical level.
D000200:Action Potentials; D000818:Animals; D002415:Cats; D003655:Decerebrate State / Q000503:physiopathology*; D004569:Electroencephalography; D004576:Electromyography; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology; D010433:Pentylenetetrazole; D011712:Pyramidal Tracts / Q000503:physiopathology; D012154:Reticular Formation / Q000503:physiopathology; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D010433:Pentylenetetrazole