Electron microscopic study of the regeneration in vivo of rat peritoneal mast cells after histamine secretion.
Peritoneal mast cells regenerate their histamine granules in 5-6 weeks after intraperitoneal injection of the degranulating agent compound 48/80. In the beginning of the regeneration the small exocytic cavities containing the non-secreted granule remnants coalesce to a single large cavity. Later on this cavity decreases in size and becomes a small vacuole containing a very condensed material. After two weeks of regeneration mast cells are already capable of another secretory event.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002467:Cell Nucleus / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005089:Exocytosis; D006056:Golgi Apparatus / Q000648:ultrastructure; D006636:Histamine Release; D008297:Male; D008407:Mast Cells / Q000502:physiology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains