The reactivation of human interferons by guanidine thiocyanate.
The addition of 1.5 M guanidine thiocyanate (GuSCN) reactivates inactive human leukocyte interferon. The biological activity of inactivated human fibroblast interferon can be only partially recovered with GuSCN if additional (thermal) energy is supplied.
D005347:Fibroblasts; D006146:Guanidines / Q000494:pharmacology*; D006358:Hot Temperature; D006801:Humans; D007372:Interferons; D007962:Leukocytes; D011487:Protein Conformation / Q000187:drug effects; D011489:Protein Denaturation / Q000187:drug effects
D006146:Guanidines; D007372:Interferons