title: Pregnancy specific beta 1-glycoprotein and alpha 2-pregnancy associated globulin in tumours of the female genital tract.
abstract: Tumour tissues obtained from 35 patients with malignancies of the female genital tract were investigated for production of pregnancy specific beta 1-glycoprotein (PS beta 1G) and alpha 2-pregnancy associated globulin (alpha 2-PAG). PS beta 1G was found in all five trophoblastic tumours studied and in 10 of the 30 nontrophoblastic cancers. alpha 2-PAG was not detected in any of the neoplastic tissues. In 18 of the patients with non-trophoblastic tumours PS beta 1G and alpha 2-PAG serum concentrations were also determined. No correlation between serum and tissue findings were noted. Thus, PS beta 1G does not seem to be a valuable serum indicator for monitoring the extent or variation of tumour mass in nontrophoblastic gynecological malignancies. Likewise, alpha 2-PAG is unlikely to serve as a clinical useful tumour marker in various gynecological cancers.
mesh_terms: D000510:Alpha-Globulins / Q000032:analysis* / Q000097:blood; D005260:Female; D005833:Genital Neoplasms, Female / Q000032:analysis* / Q000097:blood; D006023:Glycoproteins / Q000032:analysis* / Q000097:blood; D006801:Humans
chemical_list: D000510:Alpha-Globulins; D006023:Glycoproteins