An homogeneous population of beta 1-adrenoceptors subserves inhibitory responses in guinea-pig ileal preparations.
In transmurally stimulated guinea-pig ileal preparations, the pA2 values obtained with the selective beta 1- and beta 2-adrenoceptor antagonists atenolol and ICI 118,551 were independent of the beta-adrenoceptor agonist used [-)-isoprenaline or fenoterol) and were similar to values reported in isolated cardiac tissue. On the basis of these results, the relaxant responses to beta-adrenoceptor agonists in guinea-pig ileal preparations appear to be mediated by an homogeneous population of beta 1-adrenoceptors.
D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D005280:Fenoterol / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology
D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; D005280:Fenoterol; C026777:ICI 118551; D001262:Atenolol; D007545:Isoproterenol