title: Enzymatic and mechanically induced subretinal neovascularization.
abstract: Mechanical and enzymatic disruption of Bruch's membrane and induction of subretinal neovascularization in an experimental primate model have produced limited success. The methods and results are reported here to identify some problems encountered in methodology and to detail the results of this approach to subretinal neovascularization.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D008251:Macaca; D008253:Macaca mulatta; D008268:Macular Degeneration / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D003012:Microbial Collagenase / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000187:drug effects*; D012160:Retina / Q000473:pathology; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D006821:Hyaluronoglucosaminidase; D003012:Microbial Collagenase