[Repair of bleomycin-induced damage to Escherichia coli DNA. II. Participation of inducible processes].
The role of inducible cell functions in repair and mutagenesis after bleomycin-induced DNA damages was studied in Escherichia coli. Influence on these processes of some rec genes as well as sbcB, the structural gene for exonuclease I, was investigated. The data obtained suggest that this enzyme plays a negative role in the repair of DNA damaged by bleomycin. The hypersensitivity of recA mutant to bleomycin and recAlexA-dependence of bleomycin-induced mutagenesis do not suggest any principal differences between UV-induced pyrimidine dimers and apyrimidinic sites in the case of post-replication repair.
D001426:Bacterial Proteins / Q000096:biosynthesis; D001761:Bleomycin / Q000494:pharmacology*; D004260:DNA Repair; D004269:DNA, Bacterial / Q000528:radiation effects; D004352:Drug Resistance, Microbial; D004790:Enzyme Induction; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005796:Genes / Q000187:drug effects*; D009154:Mutation; D013045:Species Specificity; D014466:Ultraviolet Rays
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D001761:Bleomycin
Reparatsiia indutsirovannykh bleomitsinom povrezhdeniĭ DNK u Escherichia coli. Soobshchenie II. Uchastie indutsibel'nykh protsessov.