A contribution to the postnatal enzymatic state of maturity of gyrus hippocampi in the embryofetal alcohol syndrome of the rat.
The influence of maternal chronic alcoholism on fetal brain development was investigated in rats. A decrease in the activity of succinate, glycerin-1-phosphate, glucose-6-phosphate dehydrogenases and of tetrazolium reductases was found. The amount of total RNA was reduced in the neonates with alcohol damage. Moreover, a retardation of myelinisation at the time of birth was observed.
D000818:Animals; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006624:Hippocampus / Q000201:enzymology*; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D011247:Pregnancy; D012313:RNA / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D012313:RNA; D010088:Oxidoreductases; D005993:Glycerolphosphate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D009246:NADH Tetrazolium Reductase