Ribavirin suppresses replication of lymphadenopathy-associated virus in cultures of human adult T lymphocytes.
The in-vitro effect of ribavirin on the replication of lymphadenopathy-associated virus (LAV), one of the prototype viruses aetiologically associated with lymphadenopathy syndrome and acquired immunodeficiency syndrome, was tested. Ribavirin, a nucleoside, suppressed the replication of LAV in cultures of human adult T lymphocytes. Suppression occurred at ribavirin concentrations of 50 micrograms/ml or higher.
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D002478:Cells, Cultured; D017977:Deltaretrovirus / Q000276:immunology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005455:Fluorescent Antibody Technique; D006801:Humans; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects*
D000956:Antigens, Viral; D012263:Ribonucleosides; D012254:Ribavirin