Is the Na+,K+-ATPase symmetrically distributed in the neuroepithelium of the vestibular system in the axolotl (Ambyostoma mexicanum)?
This study was undertaken to assess the localization of the Na+,K+-ATPase in the neuroepithelial cells of the macula sacculi. In vitro perilymphatic (basolateral) perfusion with ouabain produced a significant drop in the membrane potential. Endolymphatic (apical) application of ouabain had practically no effect on membrane potentials. This suggests that Na+,K+-ATPase is asymmetrically distributed in the neuroepithelial cells.
D008267:Acoustic Maculae / Q000201:enzymology*; D000558:Ambystoma mexicanum; D000818:Animals; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D010498:Perilymph / Q000187:drug effects; D012444:Saccule and Utricle / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis*
D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase