title: Serotonin metabolism of animal model of depression.
abstract: All results presented here would indicate that serotonin plays an important role in animal behavior such as locomotor depression and that, taking into consideration the effects of antidepressants on 5-HT receptor activity as well as recent biochemical findings of human depression, some forms of human depression could be induced by a cerebral serotonergic receptor hyperactivity contrary to a conventional theory of serotonin deficiency in the synaptic cleft in the brain.
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism; D003213:Conditioning, Psychological; D003863:Depression / Q000139:chemically induced / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009043:Motor Activity; D009068:Movement; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013747:Tetrabenazine / Q000494:pharmacology
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine; D013747:Tetrabenazine