Persistent bipolar illness after steroid administration.
A 28-year-old woman received a single course of corticosteroids for treatment of ulcerative colitis. She subsequently became depressed; shortly thereafter, signs of mania developed. Despite discontinuation of corticosteroid therapy, the patient has had five bouts of mania, closely followed by severe depression, in the past 1 1/2 years. This seems to be the first case of persistent bipolar illness after exogenous steroid administration.
D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008775:Methylprednisolone / Q000009:adverse effects / Q000031:analogs & derivatives; D000077555:Methylprednisolone Acetate; D011241:Prednisone / Q000009:adverse effects
D005938:Glucocorticoids; D000077555:Methylprednisolone Acetate; D011241:Prednisone; D008775:Methylprednisolone