Anticoagulant effects of sulphated polysaccharides in normal and antithrombin III-deficient plasmas.
1 Comparison of the effects of sulphated polysaccharides on thrombin-induced clotting of normal and antithrombin III-deficient plasmas suggests the involvement of antithrombin III (AT III) in the anticoagulant activities of cellulose, dextran and xylan sulphates. 2 AT III appears to play little or no role in the anticoagulant activity of carrageenans.
D000925:Anticoagulants; D020152:Antithrombin III Deficiency; D001777:Blood Coagulation / Q000187:drug effects*; D002351:Carrageenan / Q000494:pharmacology; D002482:Cellulose / Q000494:pharmacology*; D003871:Dermatan Sulfate / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D013918:Thrombin Time; D014990:Xylans / Q000494:pharmacology
D000925:Anticoagulants; D003911:Dextrans; D006025:Glycosaminoglycans; D014990:Xylans; D003871:Dermatan Sulfate; D002351:Carrageenan; D002482:Cellulose; D006493:Heparin