Prophylaxis of deep vein thrombosis in patients with fracture of the femoral neck: a prospective comparison between dextran and a sulphated polysaccharide.
A prospective and randomized study of 100 patients with fracture of the femoral neck was carried out. The aim was to compare the thromboembolic prophylactic effect of dextran 70 and a sulphated polysaccharide, PZ 68. Deep vein thrombosis was diagnosed using the 125I-fibrinogen test and phlebography, and pulmonary embolism with a perfusion and ventilation scan. The number of thromboses and emboli did not differ significantly between the two groups. However, there was a general tendency for predominance of thrombosis on the operated side. Six patients were excluded in the PZ 68 group because of major haemorrhage.
D000368:Aged; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D005265:Femoral Neck Fractures / Q000601:surgery*; D005340:Fibrinogen; D005593:Fracture Fixation, Internal; D006493:Heparin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000517:prevention & control; D011897:Random Allocation; D013924:Thrombophlebitis / Q000517:prevention & control*
D003911:Dextrans; D007457:Iodine Radioisotopes; C029848:PZ68B; D005340:Fibrinogen; D006493:Heparin