Analysis of the gamma chains in a homozygote for HPFH Negro type and in three related heterozygotes.
The gamma-chain structure of a homozygote for HPFH Negro type, previously described by Acquaye and co-workers, and of 3 heterozygotes of the same family has been evaluated. G gamma and A gamma chains were present in a ratio of fetal type (7/3) in the homozygote and in ratios of 2/3 and 1/1 in the heterozygotes, in agreement with data of the literature. T gamma chains were absent in all the cases. Our results, compared with those previously reported for Negro and Greek HPFH, suggest that the T gamma gene is never linked with the HPFH determinant.
D000596:Amino Acids / Q000032:analysis*; D005260:Female; D005319:Fetal Hemoglobin / Q000235:genetics / Q000302:isolation & purification*; D006441:Hemoglobin A / Q000302:isolation & purification; D006443:Hemoglobin A2 / Q000302:isolation & purification; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D010375:Pedigree
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D006441:Hemoglobin A; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin