Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells.
Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes. Thus, analogues of retroviral transforming genes are both present and frequently expressed in human neoplastic cells.
D001483:Base Sequence; D002460:Cell Line; D002472:Cell Transformation, Viral; D005260:Female; D005814:Genes, Viral; D005909:Glioblastoma; D006801:Humans; D008545:Melanoma; D009369:Neoplasms / Q000235:genetics*; D011061:Poly A / Q000235:genetics*; D014176:Protein Biosynthesis; D012313:RNA / Q000235:genetics*; D012333:RNA, Messenger; D012190:Retroviridae / Q000235:genetics*; D012509:Sarcoma; D013724:Teratoma; D014158:Transcription, Genetic
D012333:RNA, Messenger; D011061:Poly A; D012313:RNA