title: Clinical implications of recent advances in hemoglobin disorders.
abstract: The greater availability of sophisticated diagnostic procedures has led to the discovery of more than 350 abnormal human hemoglobins. Whereas most are clinically silent, in a sizeable number of variants, function anomalies and disease states. Their more clinically relevant aspects are discussed.
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D001803:Blood Transfusion; D005260:Female; D005319:Fetal Hemoglobin / Q000096:biosynthesis; D005914:Globins / Q000235:genetics; D006453:Hemoglobinopathies / Q000175:diagnosis*; D006455:Hemoglobins, Abnormal; D006358:Hot Temperature; D006801:Humans; D008107:Liver Diseases / Q000150:complications; D008171:Lung Diseases / Q000150:complications; D009154:Mutation; D010100:Oxygen / Q000097:blood; D011086:Polycythemia / Q000209:etiology; D011247:Pregnancy; D013789:Thalassemia / Q000145:classification / Q000235:genetics
chemical_list: D006455:Hemoglobins, Abnormal; D005914:Globins; D005319:Fetal Hemoglobin; D010100:Oxygen