Phosphatidic acid induces histamine secretion from rat peritoneal mast cells.
Phosphatidic acid produces a selective, dose-dependent release of histamine from rat peritoneal mast cells. The effect is independent of exogenous calcium and probably reflects mobilization of sequestered stores of the cation. The significance of these results is discussed in terms of the possible changes in membrane lipid metabolism involved in mast cell activation.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000378:metabolism*; D010712:Phosphatidic Acids / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats
D010712:Phosphatidic Acids; D010716:Phosphatidylinositols; D002118:Calcium