[Comparison in genetically hyperlipoproteinemic and normal rats of the captation and incorporation of isotopic oleic acid and glycerol at high concentration by the perfused liver].
Perfusions of isolated livers from genetically hyperlipoproteinemic Zucker fa/fa and normolipemic Zucker Fa/- rats are performed with loads of ]9,10-3H2] oleic acid and [1-14C] glycerol. The hepatic acylglycerols anabolism from these precursors is higher in the fa/fa rat than in the control Fa/- rats. Synthesis by esterification (of oleic acid) is more increased than de novo synthesis (from glycerol). The increase in lipid anabolism is due to an augmentation of the hepatic cellular mass, but this anabolism is not regulated in the same way than in the normal rat.
D000818:Animals; D005990:Glycerol / Q000378:metabolism*; D006951:Hyperlipoproteinemias / Q000235:genetics / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D009829:Oleic Acids / Q000378:metabolism*; D010477:Perfusion; D010743:Phospholipids / Q000096:biosynthesis; D051381:Rats; D014280:Triglycerides / Q000096:biosynthesis; D014316:Tritium
D009829:Oleic Acids; D010743:Phospholipids; D014280:Triglycerides; D014316:Tritium; D005990:Glycerol
Comparison chez des rats génétiquement hyperlipoprotéinémiques et des rats normaux, de la captation et de l'incorporation d' acide oléique et de glycérol marqués perfusés en quantité de charge dans le foie isolé.