title: Growth of tissue into a porous, low modulus coating on intramedullary nails: an experimental study.
abstract: The ingrowth of tissue into a coating of inert, highly porous, low-modulus composite of polytetrafluorethylene polymer and pyrolytic graphite on four-fluted intramedullary nails was used for stabilization of middiaphyseal femoral osteotomies and examined by microangiography. The observations were correlated with information obtained by histologic, microradiographic and tetracycline fluorescence technology. There was rapid healing of the osteotomy. The coating was invaded throughout by blood vessels and fibrous tissue. Invasion by bone was negligible. The composite thus appeared to retain its initial flexibility when implanted into the femoral intramedullary cavity. The force to distract both coated and uncoated nails was measured on intact femora. The unit retention strength increased to an average of 6.3 kg/cm2 up to 24 weeks, which is consistent with reported values. The composite would thus appear to have potential use as a coating for endoprostheses to produce enduring physiologic fixation.
mesh_terms: D000818:Animals; D001858:Bone Nails; D001861:Bone Regeneration; D003238:Connective Tissue / Q000502:physiology*; D004285:Dogs; D005269:Femur / Q000098:blood supply / Q000166:cytology / Q000502:physiology*; D006108:Graphite; D006622:Hip Prosthesis; D009389:Neovascularization, Pathologic; D011138:Polytetrafluoroethylene
chemical_list: D006108:Graphite; D011138:Polytetrafluoroethylene