The effect of intracerebroventricular infusion of morphine, methionine-enkephalin and D-Ala2-enkephalinamide on body temperature of rabbits.
The effect of intracerebroventricular infusions of two synthetically obtained peptides: Met-enkephalin hydrochloride and D-Ala2-Met-enkephalinamide hydrochloride, and of morphine hydrochloride on rectal temperature was investigated in conscious rabbits. Morphine hydrochloride in a dose of 240 micrograms and D-Ala2-Met-enkephalinamide hydrochloride in doses of 240 and 3000 micrograms produced a hyperthermia which was accompanied by ear vasoconstriction and shivering. No such effect ensued after Met-enkephalin, possibly due to rapid enzymatic degradation of this compound. The concept of opioid involvement in the central thermoregulatory mechanism is discussed.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004723:Endorphins / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives; D004745:Enkephalins / Q000494:pharmacology*; D005260:Female; D005334:Fever / Q000139:chemically induced; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D011817:Rabbits; D012768:Shivering / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D004723:Endorphins; D004745:Enkephalins; D004744:Enkephalin, Methionine; C013801:enkephalin-Met, Ala(2)-; D009020:Morphine