Failure of peptides (angiotensin, bradykinin, substance P, physalaemin, Met-enkephalin) to influence the cardiac action potential.
Angiotensin, bradykinin, substance P, physalaemin, and Met-enkephalin were tested for their ability to affect the action potential (AP) of the isolated guinea pig papillary muscle driven at 1/sec and 3/sec. Variables studied were height and duration of AP, dV/dtmax, half-life of recovery of dV/dtmax, and refractory period. At relevant concentrations the peptides were not effective.
D000200:Action Potentials / Q000187:drug effects; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D008297:Male; D010210:Papillary Muscles / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D010803:Physalaemin / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology
D004745:Enkephalins; D010455:Peptides; D000804:Angiotensin II; D010803:Physalaemin; D013373:Substance P; D004744:Enkephalin, Methionine; D001920:Bradykinin