title: Electron-microscopic localization of Trypanosoma brucei gambiense transmitted by Glossina morsitans centralis in Microtus montanus.
abstract: In Microtus montanus infected with T. b. gambiense, electron microscopic examination of lymph nodes, spleen, liver, heart, choroid plexus and brain demonstrated extravascular populations of trypanosomes distributed throughout interstitial spaces, accompanied by a moderate cellular infiltration of plasma cells. The trypanosomes exhibited numerous profiles; some were dividing, others were in different stages of lysis, or phagocytosed. Penetration of trypanosomes into hepatocytes was observed. The present investigation indicated that trypanosomes migrated to the brain parenchyma from the Virchow-Robin spaces but could not confirm whether the parasites reached the Virchow-Robin spaces by traversing the ependymal cells lining the choroid plexus or by migrating through the endothelial cells of the cerebral blood vessels.
mesh_terms: D000818:Animals; D003411:Arvicolinae; D001921:Brain / Q000469:parasitology*; D002196:Capillaries / Q000469:parasitology; D002455:Cell Division; D002831:Choroid Plexus / Q000469:parasitology; D005110:Extracellular Space / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008198:Lymph Nodes / Q000469:parasitology / Q000473:pathology; D008214:Lymphocytes; D008264:Macrophages / Q000469:parasitology; D008854:Microscopy, Electron; D010587:Phagocytosis; D010950:Plasma Cells; D013154:Spleen / Q000469:parasitology / Q000473:pathology; D014347:Trypanosoma brucei gambiense / Q000502:physiology* / Q000648:ultrastructure; D014353:Trypanosomiasis, African / Q000469:parasitology* / Q000473:pathology / Q000635:transmission; D014370:Tsetse Flies / Q000469:parasitology