Response of adrenal catecholamine to a newly synthesized chemical radioprotector.
This study was undertaken to try a newly synthesized compound (1-acetyl hydrazinyl thiophenyl formamidine dihydrochlorie) as a chemical radioprotector and to observe its effects on adrenal catecholamine and protein bound iodine (PBI). After whole-body irradiation, the catecholamine and serum PBI levels decreased significantly but treatment with the drug before irradiation increased the same. The whole-body irradiation resulted in a 50% mortality within a fortnight whereas the use of the drug prevented it.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D013960:Thyroid Function Tests
D000578:Amidines; D002395:Catecholamines; D011837:Radiation-Protective Agents; C030806:1-acetylhydrazinylthiophene formamidine