title: [Effectiveness of commercial polyvalent proteinase inhibitors. Comparative analysis of their effect on kallikreins from different sources and trypsin].
abstract: Polyvalent peptide-protein inhibitors of proteinases trasilol, contrical, hordox and pantrypine were studied using purified preparations of kallikreins from human blood plasma and hog pancreas as well as of trypsin. All the trade grade preparations of the inhibitors studied exhibited more distinct affinity to trypsin and tissue kallikrein as compared with blood plasma kallikrein. Trasilol inhibited most effectively the activity of trypsin, contrical--of pancreatic kallikrein. Contrical, trasilol and hordox inactivated blood plasma kallikrein at similar rates, pantrypine was several times less effective.
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D006801:Humans; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000097:blood / Q000302:isolation & purification; D010179:Pancreas / Q000201:enzymology; D010455:Peptides / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D013045:Species Specificity; D013552:Swine; D014361:Trypsin Inhibitors / Q000494:pharmacology
chemical_list: D010455:Peptides; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; C011475:gordox; C003041:pantripin; D007611:Aprotinin; D007610:Kallikreins
vernacular_title: Effektivnost' deĭstviia kommercheskikh polivalentnykh ingibitorov proteinaz. Sravnitel'nyĭ analiz deĭstviia na kallikreiny razlichnogo proiskhozhdeniia i tripsin.