Predictive value of plasma CEA levels: preoperative prognosis and postoperative monitoring of patients with colorectal carcinoma.
Plasma CEA levels were determined in 280 patients with histologically proven colorectal carcinoma: in 180 once or twice preoperatively and repeatedly postoperatively, and in 100 postoperatively only. Preoperative levels correlated directly with surgical-pathologic state and inversely with the time of recurrence; i.e., groups of patients with more advanced stage showed higher proportion of elevated CEA levels, and patients with higher levels had recurrences earlier. Levels above 20 ng/ml were strongly suggestive of liver metastases or disseminated disease. Postoperative plasma CEA levels displayed three patterns of variation. 1) Levels fluctuating within normal range, below 3.2 ng/ml, strongly evidenced that surgery was effective, and 2) those fluctuating below 7.5 ng/ml indicated usually nonmalignant concomitant disease; in either group no more than 10 per cent of the patients had recurrences. 3) Levels rising persistently from a postoperative nadir indicated recurrence or, when the rise was dramatic, liver metastases or disseminated cancer in at least 97 per cent of the patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003110:Colonic Neoplasms / Q000097:blood* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood; D009367:Neoplasm Staging; D010166:Palliative Care; D011184:Postoperative Period; D011379:Prognosis; D012004:Rectal Neoplasms / Q000097:blood* / Q000601:surgery
D002272:Carcinoembryonic Antigen