[Determination of sulfapyridine levels in serum--a possibility for the control of dose related therapy with sulfasalazine].
For determination of the sulphapyridine level there were used 83 sera of 57 patients with Crohn's disease or ulcerative colitis which were treated with salazosulphapyridine. In 22,8 percent there was a sulphapyridine level higher than the therapeutic range of the whole sulphapyridine of 20-50 micrograms/ml. The serum levels are below this range frequently. Sulphonamide containing drugs yield too high values. Generally no sulphapyridine is shown in the serum because of the missing splitting of the salazosulphapyridine in patients with colectomie. Low serum values are found at low patient-compliance. In diarrhoea sulphapyridine levels in the serum are decreased. Determination of the sulphapyridine level is suitable: a) for recognition of too high serum levels and therefore for prevention of side effects b) to make sure that the therapeutic range is reached.
D000328:Adult; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000097:blood / Q000188:drug therapy*; D003424:Crohn Disease / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D013424:Sulfanilamides / Q000097:blood*; D013427:Sulfapyridine / Q000097:blood*; D012460:Sulfasalazine / Q000627:therapeutic use*
D013424:Sulfanilamides; D012460:Sulfasalazine; D013427:Sulfapyridine
Die Bestimmung des Sulfapyridinspiegels im Serum--eine Möglichkeit der Kontrolle einer dosisgerechten Therapie mit Sulfasalazin.