Brain fibroblast growth factors do not stimulate myelination or remyelination in tissue culture.
Myelin basic protein fragments that stimulated proliferation of fibroblasts in vitro did not enchance myelin formation or remyelination in nervous system tissue cultures. Similar fragments are present during demyelination in multiple sclerosis, but the lack of myelin stimulating activity in vitro suggests that they may not play a role in remyelination in vivo.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002417:Cattle; D002478:Cells, Cultured; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology; D004261:DNA Replication / Q000187:drug effects; D004622:Embryo, Mammalian; D005346:Fibroblast Growth Factors; D051379:Mice; D008807:Mice, Inbred BALB C; D004676:Myelin Basic Protein / Q000494:pharmacology*; D009186:Myelin Sheath / Q000187:drug effects / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*
D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins; D010455:Peptides; D005346:Fibroblast Growth Factors