[Comparative effectiveness of epsilon-aminocaproic acid and contrical in preventing complement activation on immune complexes].
Experiments on formation of circulatory immune complexes followed by activation of the complement components were made on sensitized guinea-pigs after intravenous injection of human gamma-globulin as specific antigen. epsilon-Aminocaproic acid did not affect the formation of circulatory immune complexes but significantly inhibited complement activation. Contrykal did not alter the formation of the immune complexes but slightly inhibited activation of the complement components.
D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D007611:Aprotinin / Q000494:pharmacology*; D003167:Complement Activation / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D005719:gamma-Globulins / Q000276:immunology
D000614:Aminocaproates; D005719:gamma-Globulins; D007611:Aprotinin; D015119:Aminocaproic Acid
Sravnitel'naia éffektivnost' epsilon-aminokapronovoĭ kisloty i kontrikala v predotvrashchenii aktivirovaniia komplementa na immunnykh kompleksakh.