T-T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen-specific T helper cells release nonspecific mediator(s) able to help induction of H-2-restricted  cytotoxic T lymphocyte responses across cell-impermeable membranes.
T helper cell induction and the specificity of T cell-mediated help as generated during alloreactive and H-2-restricted, virus- or hapten-specific cytotoxic T lymphocyte (CTL) responses have been compared. With the use of a double-chamber culture system, it was possible to dissect and separately analyze the induction phase of T helper cells from the T helper cell effector function. The data obtained revealed that during alloreactive as well as H-2-restricted T cell responses, antigen-specific T helper cells are induced. Upon specific restimulation of T helper cells, helper cell function is mediated across a cell-impermeable membrane via soluble products in an apparently nonspecific and nonrestricted manner. The data suggest that similar rules govern T-T cell interactions in alloreactive and H-2-restricted CTL responses.
D000818:Animals; D002463:Cell Membrane Permeability; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006183:H-2 Antigens; D007519:Isoantigens; D008211:Lymphocyte Cooperation; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010222:Parainfluenza Virus 1, Human / Q000276:immunology; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D014301:Trinitrobenzenes / Q000276:immunology
D000939:Epitopes; D006183:H-2 Antigens; D007519:Isoantigens; D014301:Trinitrobenzenes