Effect of histamine on cyclic AMP levels in the submandibular gland.
Histamine and 4-methylhistamine increased on cyclic AMP level in chopped guinea-pig submandibular glands. 4-Methylhistamine was more active than histamine. 2-(2-Pyridyl)ethylamine was less active than histamine or almost inactive. Metiamide markedly antagonized the histamine-induced cyclic AMP increase but mepyramine had no inhibitory effect on this increase. These results suggest that there are H2-receptors which mediate the cyclic AMP response to histamine in the guinea-pig submandibular gland.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D008761:Methylhistamines / Q000494:pharmacology; D008785:Metiamide / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D013363:Submandibular Gland / Q000378:metabolism*
D008761:Methylhistamines; D008785:Metiamide; C025566:4-methylhistamine; D006632:Histamine; D000242:Cyclic AMP; D011738:Pyrilamine; D015056:1-Methyl-3-isobutylxanthine