Role of arginase in sciatectomized muscle.
Substrate kinetics of arginase were investigated in normal and sciatectomized gastrocnemius muscle of frog. Sciatectomized muscle arginase showed 47% elevation in V while Km showed no change. Sciatectomic activation of muscle arginase accounted for the stepped up urea levels which may be of significant use in combating ammonia toxicity and maintaining chemohomeostasis.
D000818:Animals; D001119:Arginase / Q000378:metabolism*; D004789:Enzyme Activation; D007700:Kinetics; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology*; D011898:Ranidae; D012584:Sciatic Nerve / Q000502:physiology*; D014508:Urea / Q000378:metabolism
D014508:Urea; D001119:Arginase