A corneal micropocket assay for angiogenesis in the rat eye.
A corneal micropocket assay for angiogenesis in the rat eye is described in detail. With our test system, a partially purified, low molecular-weight endothelial cell growth stimulatory factor isolated from the Walker 256 rat carcinosarcoma is demonstrated to have potent angiogenic activity in vivo. The advantages and applications of our rat corneal assay are discussed.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000503:physiopathology*; D003315:Cornea / Q000098:blood supply* / Q000473:pathology; D006133:Growth Substances / Q000502:physiology; D008297:Male; D009374:Neoplasms, Experimental / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D051381:Rats
D006133:Growth Substances