The involvement of proteases and protease inhibitors in neovascularization.
Bovine capillary endothelial cells have been found to respond to several stimuli by producing increased amounts of plasminogen activator and latent collagenase. These stimulators include the tumor promoter tetradecanoyl phorbol-13-acetate as well as crude preparations from a human hepatoma, bovine retinae, and mouse adipocytes, all of which are known to contain angiogenic factors. Endothelial cells and skin fibroblasts do not respond to these stimuli in the same way, indicating a specificity of the response. In addition, inhibitors of plasmin and vertebrate collagenase have been isolated from cartilage, a tissue resistant to neovascularization. We have proposed that these specific protease inhibitors confer on cartilage its antiangiogenic properties.
D000273:Adipose Tissue / Q000502:physiology; D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000201:enzymology*; D006528:Carcinoma, Hepatocellular / Q000503:physiopathology; D002356:Cartilage / Q000201:enzymology; D002417:Cattle; D002999:Clone Cells; D004727:Endothelium / Q000201:enzymology; D008113:Liver Neoplasms; D003012:Microbial Collagenase / Q000378:metabolism; D009389:Neovascularization, Pathologic; D010447:Peptide Hydrolases / Q000502:physiology*; D010960:Plasminogen Activators / Q000378:metabolism; D011480:Protease Inhibitors / Q000502:physiology*; D012160:Retina / Q000502:physiology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D043925:Angiogenesis Inducing Agents; D011480:Protease Inhibitors; D010447:Peptide Hydrolases; D010960:Plasminogen Activators; D003012:Microbial Collagenase; D013755:Tetradecanoylphorbol Acetate