Chromosomal aberrations in the peripheral lymphocytes of cancer patients treated with high-energy electrons and bleomycin.
5 patients with inoperable bronchogenic carcinomas on a weekly therapy with a low dose of bleomycin (BL) plus irradiation with high-energy electrons, were analysed cytogenetically by cultivating peripheral lymphocytes taken immediately before the BL treatments and some hours before the irradiations. For the induction of dicentric chromosomes, linear dose-effect relationships were found: 3 of the patients responded with similar dose-effect relationships. The other 2 were different: they were not comparable with those 3 or with each other. These results were unexpected because all 5 patients received similar types of treatment.
D000368:Aged; D001761:Bleomycin / Q000627:therapeutic use*; D002283:Carcinoma, Bronchogenic / Q000235:genetics* / Q000628:therapy; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000628:therapy; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D014965:X-Rays
D001761:Bleomycin