title: Origin and significance of intranuclear tubular inclusions in type II pulmonary alveolar epithelial cells of patients with bleomycin and busulfan toxicity.
abstract: Abundant intranuclear tubular structures were observed in type II alveolar pneumocytes in lung biopsies from patients with bleomycin and busulfan toxicity. It is proposed that since chromatin-membrane interactions in eukaryotic cell nuclei do occur, the intranuclear proliferation of the tubular structures occurs as a result of the interaction of the drug with perichromatin.
mesh_terms: D001761:Bleomycin / Q000009:adverse effects*; D002066:Busulfan / Q000009:adverse effects*; D002467:Cell Nucleus / Q000648:ultrastructure*; D002843:Chromatin / Q000648:ultrastructure; D004848:Epithelium / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008870:Microtubules / Q000648:ultrastructure*; D011658:Pulmonary Fibrosis / Q000209:etiology
chemical_list: D002843:Chromatin; D001761:Bleomycin; D002066:Busulfan