Retinol-binding protein and beta 2-microglobulin in urine of cadmium-fed rhesus monkeys.
Retinol-binding protein (RBP) in the Rhesus monkey had the same electrophoretic mobility, molecular weight, and common antigens as human RBP; beta 2-microglobulin protein (MG) had similar electrophoretic mobility and partial common antigens to human MG. After a prolonged oral administration of cadmium chloride to 10 monkeys over a period of 55 weeks, one monkey of the 30 mg Cd/day group indicated RBPuria and MGuria with the use of anti-human RBP and MG sera when proteinuria appeared. The immunological assay of low-molecular-weight proteins in urine was not applicable for the early detection of cadmium health effects in monkeys.
D000818:Animals; D001609:Beta-Globulins / Q000652:urine*; D002105:Cadmium Poisoning; D003429:Cross Reactions; D008253:Macaca mulatta; D008297:Male; D008970:Molecular Weight; D011507:Proteinuria / Q000139:chemically induced*; D012177:Retinol-Binding Proteins / Q000276:immunology / Q000652:urine*; D001613:beta 2-Microglobulin / Q000276:immunology / Q000652:urine*
D001609:Beta-Globulins; D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin