title: [Reactions of primed lymphocytes (PLT) and their genetic determination (author's transl)].
abstract: Lymphocytes of one family member, if cultured in a primary culture with HLA haploidentical lymphocytes of another family member are primed by the foreign HLA haplotype. Primed lymphocytes can recognize cells bearing the priming haplotype in a secondary culture. The kinetics of this reaction (primed lymphocyte typing, PLT) and its genetic regulation were investigated in one family with a HLA-DR homozygous, HLA-D heterozygous member, one family with two HLA-D homozygous probands, one family with a recombination within the HLA system and in three normal families.
mesh_terms: D000939:Epitopes; D006680:HLA Antigens; D006579:Heterozygote; D000949:Histocompatibility Antigens Class II; D006720:Homozygote; D006801:Humans; D007700:Kinetics; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D011995:Recombination, Genetic
chemical_list: D000939:Epitopes; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II
vernacular_title: Reaktionen geprägter Lymphozyten (PLT) und deren genetische Steuerung.