Prostaglandin A compounds as antiviral agents.
Prostaglandins of the A series strongly inhibit the production of Sendai virus in African green monkey kidney cells and are able to prevent the establishment of persistent infection ("carrier" state). This action is specific for prostaglandin A and is not due to alteration in the host cell metabolism or in the virus infectivity. The possibility that this effect is mediated by interferon is discussed.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D000882:Haplorhini; D007372:Interferons / Q000494:pharmacology; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology; D011454:Prostaglandins A / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013931:Thromboxanes / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D001095:Arachidonic Acids; D011453:Prostaglandins; D011454:Prostaglandins A; D013931:Thromboxanes; D007372:Interferons