Cytotoxic T cell interactions with antigen. Potential relevance for drug-related lupus.
Understanding of cytotoxic T cell recognition may be relevant to the study of drug-related lupus because either cell-mediated cytotoxicity (CMC) contributes to triggering the disease or CMC provides an informative model to study T cell recognition of foreign antigen. As a model, CMC demonstrates the following: 1) Antigen presentation can occur by membrane insertion of the antigen, covalent modification of the cell surface, or cell surface adsorption of the antigen; these may be modes of presentation by which drug-related antigens induce adverse responses. 2) HLA antigens regulate a wide variety of immune responses; this may be crucial in drug-related lupus since HLA antigens may regulate autoimmune responses, may affect an individual's susceptibility to lupus, and may increase the risk for other specific adverse drug reactions.
D000941:Antigens; D002450:Cell Communication; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006680:HLA Antigens; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009928:Organ Specificity; D013601:T-Lymphocytes / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
D000941:Antigens; D000939:Epitopes; D006680:HLA Antigens; D014301:Trinitrobenzenes