title: Absence of L-histidine lyase and histidine imidazole metabolites in human adenomatous prostate.
abstract: The histidine metabolism in homogenates of human tissues of nontreated benign prostatic hyperplasia has been examined by means of the determination of L-histidine ammonia lyase activity (EC 4.3.1.3;histidine alpha-deaminase, histidase) and the histidine imidazole metabolites which were separated by means of ion exchange chromatography. Neither enzymatic activity nor metabolites of histidine could be detected. It is concluded that non-treated benign prostatic hyperplasia lacks L-histidine ammonia lyase activity and subsequently the metabolic pathway of histidine.
mesh_terms: D000642:Ammonia-Lyases / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism*; D006638:Histidine Ammonia-Lyase / Q000378:metabolism*; D006801:Humans; D007093:Imidazoles / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000601:surgery
chemical_list: D007093:Imidazoles; D006639:Histidine; D000642:Ammonia-Lyases; D006638:Histidine Ammonia-Lyase