Characterization of catecholamine binding sites in the rat brain.
A systematic study of the effect of neurotoxic agents upon neurotransmitter binding to specific receptors requires the simultaneous assay of several closely related ligand-receptor interactions. Conditions are presented which allow the determination of dopaminergic, alpha-noradrenergic and beta-noradrenergic receptor sites within the same brain areas without major overlap of selectivity. As a result, regional distribution of catecholaminergic receptor sites and some characteristics of such binding are described.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002069:Butaclamol / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D004088:Dihydroergotoxine / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
D002395:Catecholamines; D011941:Receptors, Adrenergic; D004088:Dihydroergotoxine; D013134:Spiperone; D004082:Dihydroalprenolol; D002069:Butaclamol; D006220:Haloperidol