title: Acute changes in the renin-angiotensin-aldosterone system, catecholamines and prostaglandins during captopril in man.
abstract: The acute hypotensive effect of 25 mg captopril was investigated in 26 hypertensive patients (11 essential and 15 with renal arterial disease). Intra-arterial blood pressure was recorded continuously and arterial blood was sampled for renin, angiotensin I and II, aldosterone, kininase II, catecholamines and prostaglandins. Captopril provoked increases in plasma renin activity, active and total plasma renin concentration and angiotensin I; decreases in plasma kininase II activity, angiotensin II, aldosterone, prostaglandins E2 and F2 alpha and no changes in plasma (nor)adrenaline, dopamine and inactive renin concentration.
mesh_terms: D000328:Adult; D002216:Captopril / Q000494:pharmacology* / Q000627:therapeutic use; D002395:Catecholamines / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D011453:Prostaglandins / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects*
chemical_list: D002395:Catecholamines; D011453:Prostaglandins; D002216:Captopril