Variations in the numbers and dimensions of tissue channels after injury.
The dimensions and numbers of tissue channels were estimated, using transmission electron microscopy after filling them with ferri-ferrocyanide precipitate, in the subcutaneous tissue of mice. They were studied in the normal condition, and at varying times after a simple incised wound. After this injury they increased very greatly indeed in numbers and dimensions, being maximal at 1 week. Six months elapsed before they returned to normal. The hydraulic conductivity was calculated. It increased by 10(5) times at the maximum, when clinical oedema was present.
D000818:Animals; D004058:Diffusion; D005110:Extracellular Space / Q000502:physiology; D051379:Mice; D008833:Microcirculation; D008854:Microscopy, Electron; D012867:Skin / Q000293:injuries; D013194:Staining and Labeling; D013997:Time Factors; D014947:Wounds and Injuries / Q000473:pathology*