Interaction of targeted liposomes with human peripheral mononuclear blood cells and lymphocytes of chronic lymphoid leukaemic patients.
Association of small unilamellar vesicles (SUV) can be effectively targeted to normal human peripheral mononuclear blood cells (PMBC). - Lymphocytes of chronic lymphoid leukaemic (CLL) patients show a low rate of liposome association, which cannot be improved by targeting with anti-lymphocyte globulin (ALG). Presence of serum evoked an enhanced association of liposomes to PMBC.
D000818:Animals; D000961:Antilymphocyte Serum; D006801:Humans; D007074:Immunoglobulin G; D007945:Leukemia, Lymphoid / Q000097:blood*; D008081:Liposomes; D008214:Lymphocytes / Q000502:physiology*; D009000:Monocytes / Q000502:physiology*; D009439:Neuraminidase / Q000494:pharmacology; D011402:Pronase / Q000494:pharmacology; D011817:Rabbits; D000511:alpha-Macroglobulins
D000961:Antilymphocyte Serum; D007074:Immunoglobulin G; D008081:Liposomes; D000511:alpha-Macroglobulins; D009439:Neuraminidase; D011402:Pronase