F-cells are preferentially distributed among high density erythrocytes.
Red blood cells from normal subjects and subjects with heterocellular hereditary persistence of fatal haemoglobin and beta-thalassaemia were fractionated according to density by centrifugation on a discontinuous gradient of Stractan II. F-cells were studied by immunofluorescence and their proportion was evaluated in each separated population. This approach has permitted to show that F-cells were preferentially distributed among high density erythrocytes. This phenomenon reflects a peculiar characteristic of F-cells.
D000818:Animals; D002469:Cell Separation; D002499:Centrifugation, Density Gradient; D004912:Erythrocytes / Q000032:analysis* / Q000166:cytology; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011817:Rabbits; D013789:Thalassemia / Q000097:blood*; D014461:Ultracentrifugation
D005319:Fetal Hemoglobin