Antibiotics and antivirals do not modify experimentally-induced Creutzfeldt-Jakob disease in mice.
Thiamphenicol, rifampicin, amantadine, cytosine arabinoside and isoprinosine were administered to mice which were inoculated with brain tissue containing Creutzfeldt-Jakob disease (CJD). All the mice developed disease within 3 to 6 months after inoculation. As there was no significant shift in incubation periods among animal groups of each drug administration and non-administration, these compounds had no effect in controlling experimental CJD.
D000547:Amantadine / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D007562:Creutzfeldt-Jakob Syndrome / Q000188:drug therapy*; D003561:Cytarabine / Q000627:therapeutic use; D006801:Humans; D007542:Inosine Pranobex / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012293:Rifampin / Q000627:therapeutic use; D013839:Thiamphenicol / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D003561:Cytarabine; D000547:Amantadine; D013839:Thiamphenicol; D012293:Rifampin; D007542:Inosine Pranobex