title: [Interferon-inducing and protective action of polyguacyl in an experimental influenza infection].
abstract: A comparative study of the interferon-inducing and anti-influenza activity of polyguacyl, an interferon inducer, given to human volunteers intranasally and as an aerosol, was carried out. The induction of endogenous interferon in the blood to 100-127 units/ml was observed only after intranasal administration of 5 mg polyguacyl. By both routes of administration the inducer did not diminish the implantation of the virus and development of postvaccination reactions in volunteers to intranasal administration of live influenza A (H1N1) vaccine.
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D004341:Drug Evaluation; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000188:drug therapy* / Q000276:immunology; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use*; D007372:Interferons / Q000097:blood; D008875:Middle Aged; D010919:Placebos; D011066:Poly C / Q000008:administration & dosage / Q000627:therapeutic use*; D011068:Poly G / Q000008:administration & dosage / Q000627:therapeutic use*; D011131:Polyribonucleotides / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000336:Aerosols; D007252:Influenza Vaccines; D007369:Interferon Inducers; D010919:Placebos; D011131:Polyribonucleotides; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; D007372:Interferons
vernacular_title: Izuchenie interferonindutsiruiushchego i zashchitnogo deĭstviia poliguatsila pri éksperimental'noĭ grippoznoĭ infektsii.