Effects of iontophoretic 5-hydroxytryptamine on the unitary discharge frequency of caudate nucleus neurons in the rat.
Microiontophoretic application of 5-hydroxytryptamine (5-HT) on rat caudate nucleus neurons has both facilitatory and inhibitory effects on the discharge frequency of the neurons; in many cases 5-HT has a two-phase action. An analysis was made of the behaviour of facilitatory and inhibitory responses in time considering the mean firing rate variations during and after 5-HT iontophoretic release. The experimental results were statistically elaborated.
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D004553:Electric Conductivity; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin