Action of antischistosomal drugs, hycanthone and its analog 1A-4 N-oxide, on viral interferon induction.
Two antischistosomal drugs, hycanthone and its indazole analog 1A-4 N-soxide, of which the former is a potent mutagen, differed markedly in their ability to depress interferon induction by influenza virus in rhesus monkey kidney (LLC-MK2) cell cultures. At the concentration of 10 micron/ml, hycanthone reduced interferon yields as much as 73%; the same quantity of analog had no adverse effect on interferon induction. Pretreatment of cell cultures with the analog negated the inhibitory activity of hycanthone on viral interferon induction; however, this did not occur when the sequence was reversed. Interferon-mediated antiviral cellular resistance was not affected when cell cultures were pretreated with either hycanthone or 1A-4 N-oxide. A possible association may exist between the mutagenicity of antischistosomal drugs and their ability to affect interferon synthesis.
D000818:Animals; D006826:Hycanthone / Q000031:analogs & derivatives / Q000494:pharmacology*; D007191:Indazoles / Q000494:pharmacology*; D007372:Interferons / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects; D008251:Macaca; D009975:Orthomyxoviridae / Q000187:drug effects; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology*; D013892:Thioxanthenes / Q000494:pharmacology*
C026923:1A-4N oxide; D007191:Indazoles; D011720:Pyrazoles; D013892:Thioxanthenes; D006826:Hycanthone; D007372:Interferons