[Storage stability of 14 plasma proteins in ACD-AG banked blood].
In summarizing the results it can be stated that, when stored, the proteins haemopexin, alpha 1-antichymotrypsin, alpha 1-antitrypsin, which are rich of neuraminic acid, and IgA are predominantly characterized by a diminution of electrophoretic mobility and thus of concentration in electro-immunodiffusion, with the neuraminic acid content decreasing at the same time. These changes are probably caused by bacteria and/or virus neuraminidase. The decrease of pre-albumin concentration to be observed in radial-immunodiffusion and electro-immunodiffusion is caused by other mechanisms because pre-albumin contains no neuraminic acid. In accordance with these findings the most important changes of single proteins which can be measured by our equipment concern the percentage of non-proteins, whereas the antigen binding places will remain relatively stable during storage (ep. findings of radial immunodiffusion).
D001793:Blood Preservation; D001798:Blood Proteins / Q000032:analysis*; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D003451:Cryoprotective Agents; D006466:Hemopexin / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D009438:Neuraminic Acids / Q000032:analysis; D011228:Prealbumin / Q000032:analysis; D013997:Time Factors; D000515:alpha 1-Antitrypsin / Q000032:analysis
D001798:Blood Proteins; D003451:Cryoprotective Agents; D007070:Immunoglobulin A; D009438:Neuraminic Acids; D011228:Prealbumin; D000515:alpha 1-Antitrypsin; D006466:Hemopexin; D002918:Chymotrypsin
Untersuchungen zur Lagerungsstabilität von 14 Plasmaproteinen in ACD-AG-Blutkonserven.