Progress towards a unified theory of the mechanisms of carcinogenesis: role of cell cycle restriction points.
Cancer is characterized by a relatively autonomous growth of cells due to a reduced responsiveness to normal controls of proliferation and differentiation. The proliferation of normal cells is regulated at arrest (restriction) points in the cell cycle. Relatively autonomous growth (tumors) can result from various mechanisms which circumvent the normal regulatory controls of the cell cycle.
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D005353:Fibronectins / Q000502:physiology; D006131:Growth Inhibitors / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology*
D005353:Fibronectins; D006131:Growth Inhibitors; D006133:Growth Substances; D007372:Interferons; D000242:Cyclic AMP; D006152:Cyclic GMP