title: N4-hydroxycytidine: a mutagen specific for AT to GC transitions.
abstract: N4-Hydroxycytidine is a mutagen of the base-analog type and one of the products formed by treatment of cytidine with hydroxylamine. In this communication evidence is presented showing that, in contrast with other known base analogs, N4-hydroxycytidine results mainly, if not exclusively, in AT leads to GC transitional alterations in Escherichia coli K12.
mesh_terms: D003562:Cytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004260:DNA Repair; D004269:DNA, Bacterial / Q000096:biosynthesis; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D007763:Lac Operon / Q000187:drug effects; D009153:Mutagens; D012318:RNA Polymerase I / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis; D013379:Substrate Specificity
chemical_list: D004269:DNA, Bacterial; D009153:Mutagens; D012329:RNA, Bacterial; D003562:Cytidine; C010737:N(4)-hydroxycytidine; D012318:RNA Polymerase I; D004259:DNA-Directed DNA Polymerase