Fundus changes in histologically confirmed sarcoidosis.
We reviewed the clinical features, natural history and visual prognosis of 26 patients with histologically confirmed sarcoidosis. Compatible chest x-ray changes were found in 75% of patients. Periphlebitis was the commonest fundus feature. Disc changes were seen in a substantial number of patients, and the condition can present as unilateral disc oedema. The disease seems primarily to involve equatorial retinal veins, and occlusions of a hemisphere branch vein or central retinal vein did not occur. Changes in the subretinal pigment epithelium were noted in a substantial number of patients but did not produce visual morbidity, and these patients seemed to have less florid periphlebitis than others. The disease has a low visual morbidity unless neovascularisation develops; the treatment of this remains controversial.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005128:Eye Diseases / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D010211:Papilledema / Q000473:pathology; D010689:Phlebitis / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology; D010859:Pigmentation Disorders / Q000473:pathology; D011379:Prognosis; D012507:Sarcoidosis / Q000473:pathology*; D014792:Visual Acuity