Production of interferon and other lymphokines during murine tumour growth. I. Lymphokines in cell--free fluid of rat Zajdela ascites hepatoma.
Cell-free ascites of rat Zajdela hepatoma was assayed for the presence of lymphokine-like factors. Macrophage migration inhibitory and microbial growth inhibitory cytokines were detected with peak activities at day 4-8 and 10-11 after tumour inoculation, respectively. Occasionally, skin reactive activity was found, whereas only borderline titres of an interferon-like substance were demonstrated. Preliminary studies indicated that both migration inhibitory and microbial growth inhibitory factors are proteins resembling the corresponding lymphocyte-derived lymphokines. The cellular site of formation of these factors remains to be determined.
D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism*; D002918:Chymotrypsin / Q000378:metabolism; D004355:Drug Stability; D006168:Guinea Pigs; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008222:Lymphokines / Q000096:biosynthesis* / Q000494:pharmacology; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism; D013696:Temperature
D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D007372:Interferons; D012260:Ribonucleases; D002918:Chymotrypsin