Antibodies to immunoglobulin heavy chain variable regions protect helper cells from specific suicide by radiolabeled antigen.
The antigen-binding receptor of helper T cells was studied by radioactive antigen-caused suicide in vitro. Purified antibodies to immunoglobulin variable regions, obtained from sera of rabbits immunized with isolated VH and VL fragments of mouse myeloma proteins (MOPC 315, XRPC 25), were used to inhibit the binding of radiotoxic antigen. Anti-VH, but not anti-V lambda or anti-V chi inhibited suicide of carrier-primed cells.
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001665:Binding Sites; D001666:Binding Sites, Antibody; D002470:Cell Survival; D000939:Epitopes; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D008211:Lymphocyte Cooperation; D009194:Myeloma Proteins / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D000939:Epitopes; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D009194:Myeloma Proteins; D011971:Receptors, Immunologic