Fertility regulation in male rats and hamsters with alkylating agents.
A single intratesticular injection of TEPA or Thio-TEPA induced a period of infertility lasting 1-2 months. Restoration of fertility was characterized by a reduction of the litter size resulting from the first inpregnation post-treatment. There was no evidence of tissue pathogenesis 6-12 months after treatment.
D000818:Animals; D001389:Azirines / Q000008:administration & dosage*; D003272:Contraceptive Agents, Male; D006224:Cricetinae; D005260:Female; D005298:Fertility; D007267:Injections; D008098:Litter Size; D008297:Male; D011247:Pregnancy; D051381:Rats; D013737:Testis; D013852:Thiotepa / Q000008:administration & dosage*; D013721:Triethylenephosphoramide / Q000008:administration & dosage*
D001389:Azirines; D003272:Contraceptive Agents, Male; D013852:Thiotepa; D013721:Triethylenephosphoramide