title: Effect of combined antibiotic therapy on fertility in brood bitches infected with Brucella canis.
abstract: Bitches with naturally occurring Brucella canis infection were treated with combined antibiotic therapy consisting of tetracycline, dihydrostreptomycin, and trimethoprim-sulfadiazine. After treatment, all but 1 bitch became abacteremic, and serologic titers declined for a variable length of time (3 months to 1 years). Abortion did not occur while these bitches were abacteremic. Although sequential antibiotic therapy for 6 weeks did not eradicate Brucella canis from affected bitches, it did not prevent abortion. The number of live pups whelped and weaned by treated bitches was comparable with that in bitches before they became infected.
mesh_terms: D000031:Abortion, Septic / Q000517:prevention & control / Q000662:veterinary; D000034:Abortion, Veterinary / Q000517:prevention & control*; D000818:Animals; D002006:Brucellosis / Q000188:drug therapy / Q000662:veterinary*; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004971:Estrus / Q000187:drug effects; D005260:Female; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000662:veterinary*; D018805:Sepsis / Q000188:drug therapy / Q000662:veterinary; D013411:Sulfadiazine / Q000008:administration & dosage* / Q000627:therapeutic use; D013752:Tetracycline / Q000008:administration & dosage* / Q000627:therapeutic use; D014295:Trimethoprim / Q000008:administration & dosage* / Q000627:therapeutic use; D000096926:Benzenesulfonamides
chemical_list: D004096:Dihydrostreptomycin Sulfate; D004338:Drug Combinations; D013411:Sulfadiazine; D013752:Tetracycline; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides