[Non-A non-B hepatitis virus: demonstration of a double antigenic and structural kinship with hepatitis B virus].
Major antigenic identity has been demonstrated by immunodiffusion between the Ag described by Shirachi and confirmed by us (NANB/e) in the serum on non A non B hepatitis and the HBe/3 specificity of hepatitis B virus (HBV). A second Ag (NANB/c) linked to the core of a new virion morphologically similar to HBV and also associated with ADN polymerase activity as recently described, has been identified and purified from an infected liver. This NANB/c Ag also cross reacts with HBc Ag. These results confirm that HBV and the NANB virus defined here belong to the same new class of DNA viruses.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D004259:DNA-Directed DNA Polymerase / Q000032:analysis; D000939:Epitopes; D006511:Hepatitis B Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000201:enzymology / Q000276:immunology* / Q000648:ultrastructure; D006526:Hepatitis C / Q000276:immunology; D006518:Hepatitis Viruses / Q000201:enzymology / Q000276:immunology* / Q000648:ultrastructure; D006801:Humans
D000956:Antigens, Viral; D000939:Epitopes; D006511:Hepatitis B Antigens; D004259:DNA-Directed DNA Polymerase
Virus de l'hépatite non A non B: démonstration d'une double parenté antigénique et structurale avec le virus de l'hépatite B.