Screening for circulating immune complexes in blood donors as an effective method of further HBsAg carriers detection.
The loss of counterimmunoelectrophoretic (CIEP) HBsAg reactivity resulting from circulating immune complexes (CIC) formation, observed earlier, prompted us to evaluation the CIC screening in blood donors as an aid in HBsAg detecting. CIC were examined by means of a simple screening modification of the Pegikem test. Among 2.150 normal blood donors there were 21 (0.98%) CIC carriers found, in 13 (61.90%) of them HBsAg was then proved by means of a third generation test. In this population, CIC presence indicated twice as many HBsAg carriers as the CIEP. HBsAg is evidently a very important source of CIC in normal population. The CIC presence is supposed to be a good indicator of HBsAg as well. Therefore, before being accepted as blood donors, CIC carriers should be tested by sensitive test for HBsAg presence.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001782:Blood Donors; D001803:Blood Transfusion; D002353:Carrier State / Q000276:immunology*; D003378:Counterimmunoelectrophoresis; D006509:Hepatitis B / Q000276:immunology* / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans
D000936:Antigen-Antibody Complex; D006514:Hepatitis B Surface Antigens