[Metabolism of various biogenic amines in diabetes mellitus].
Serotonin (5-HT) and histamine metabolism was studied in 50 patients with diabetes melitus. Simultaneously the blood and urine content of their precursors and metabolites tryptophane, 5-hydroxytryptophane (5-HTP), 5-hydroxyindolylacetic acid (5-HIAA) and histidine was examined. An increase in 5-HT metabolism intensification (the augmented 5-HTP and 5-HT blood levels and enhanced 5-HTP and 5-HIAA excretion with the urine) was determined, whereas the blood and urine contents of histamine and histadine were within normal. Moreover, significantly higher increase in 5-HT blood level and enhanced 5-HIAA excretion with the urine were seen in patients with juvenile diabetes mellitus comparatively to those with insulin-depending type of the disease. Possible significance of changes, being discovered in 5-HT metabolism of patients with diabetes mellitus, in the disease pathogenesis is discussed.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D001679:Biogenic Amines / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D006632:Histamine / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014364:Tryptophan / Q000378:metabolism
D001679:Biogenic Amines; D006639:Histidine; D006897:Hydroxyindoleacetic Acid; D006632:Histamine; D014364:Tryptophan; D006916:5-Hydroxytryptophan
Issledovanie obmena nekotorykh biogennykh aminov u bol'nykh sakharnym diabetom.