[Optimization of the schemes for using interferon inducers].
The results of study on 2 Soviet interferon inductors, i.e. the synthetic polyguacyl polynucleotide and natural double-strand phage RNA or dsRNA were studied. It was shown that the time course of accumulation and period of circulation of interferon depended on the route of the inductor administration. The antiviral activity of polyguacyl and dsRNA in experimental influenza and tick-borne encephalitis is described. The maximum protective effect with respect to experimental influenza was observed with intranasal administration of the drugs 4 hours before inoculation. A pronounced protective effect with respect to tick-borne encephalitis was observed with intraperitoneal administration of the inductors or their use in the form of aerosols. Direct correlation between interferon production and the final protective effect was found.
D000818:Animals; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy; D007369:Interferon Inducers / Q000008:administration & dosage*; D007372:Interferons / Q000032:analysis; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D011066:Poly C / Q000008:administration & dosage; D011068:Poly G / Q000008:administration & dosage; D012330:RNA, Double-Stranded / Q000008:administration & dosage; D012367:RNA, Viral / Q000008:administration & dosage; D013997:Time Factors
D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012367:RNA, Viral; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; D007372:Interferons
Optimizatsiia skhem ispol'zovaniia induktorov interferona.