Prekallikrein-Kallikrein conversion rate as a predictor of contrast material catastrophies.
An in vitro is described that attempts to detect patients with a potential for adverse systemic reactions to contrast material. This test involves measuring the rate of conversion of prekallikrein to kallikrein under certain standard conditions. In a preliminary retrospective study, the test could be used to identify such patients with a sensitivity of 88%, a specificity of 82%, and a predictive value of 79%.
D000707:Anaphylaxis / Q000139:chemically induced / Q000175:diagnosis*; D003287:Contrast Media / Q000009:adverse effects*; D003911:Dextrans; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology; D066298:In Vitro Techniques; D007610:Kallikreins / Q000097:blood*; D008297:Male; D011288:Prekallikrein / Q000097:blood*; D012189:Retrospective Studies
D003287:Contrast Media; D003911:Dextrans; D011288:Prekallikrein; D007610:Kallikreins