title: Hypothesis: when is a seminoma not a seminoma?
abstract: A xenograft line, HX 53, has been established in immune-suppressed mice from a specimen of a lymph node metastasis in a patient with a histological diagnosis of seminoma but with markedly raised circulating levels of alpha-fetoprotein. Histological, immunocytochemical, and ultrastructural studies of this xenograft line have suggested that a solid variant of yolk sac carcinoma may exist, which morphologically resembles seminoma, or that a continuum of differentiation exists between seminoma and yolk sac carcinoma.
mesh_terms: D000328:Adult; D000818:Animals; D002460:Cell Line; D003937:Diagnosis, Differential; D004407:Dysgerminoma / Q000097:blood / Q000175:diagnosis / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008649:Mesonephroma / Q000175:diagnosis / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D013736:Testicular Neoplasms / Q000097:blood / Q000648:ultrastructure*; D014183:Transplantation, Heterologous; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins