The role of stable complexes that repress and activate eukaryotic genes.
The state of activity or repression of 5S RNA genes is built into the chromatin in the form of stable complexes. The characteristics and composition of these complexes will be described. Stable transcription complexes that activate 5S RNA genes consist of multiple factors bound tightly to a control region of the gene. Repressed 5S RNA genes do not have these factors bound to them; their repressed state is maintained by nucleosomes.
D000818:Animals; D002843:Chromatin / Q000378:metabolism; D003001:Cloning, Molecular; D005260:Female; D005786:Gene Expression Regulation; D005796:Genes; D006657:Histones / Q000235:genetics; D009865:Oocytes / Q000378:metabolism; D012335:RNA, Ribosomal / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D014981:Xenopus
D002843:Chromatin; D006657:Histones; D012335:RNA, Ribosomal; D014157:Transcription Factors