A simple and sensitive method for the determination of the biological activity of bleomycin using isolated rat liver nuclei.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001761:Bleomycin / Q000097:blood / Q000494:pharmacology*; D002467:Cell Nucleus / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008722:Methods; D051381:Rats; D013347:Subcellular Fractions / Q000032:analysis; D013942:Thymine Nucleotides / Q000378:metabolism
D013942:Thymine Nucleotides; D001761:Bleomycin; D004259:DNA-Directed DNA Polymerase; D001205:Ascorbic Acid; C024157:thymidine 5'-triphosphate