Human B cell alloantigens: expression of MB and MT determinants.
Four HLA-DR-homozygous cell lines were examined in detail to compare alpha and beta subunits precipitated by chimpanzee antisera and alloantisera directed against HLA-DR, MB, or MT determinants. For the HLA-DR5-homozygous cell line Sweig, chimpanzee antisera directed against MT2 and against the HLA-DR5 specificity yielded identical patterns. Similar findings for MT and MB vs HLA-DR were obtained for the cell lines LG14 (HLA-DR3-homozygous), PBur (HLA-DR7-homozygous), and Eld (HLA-DRw6-homozygous). Therefore, on some cell lines MT and/or MB specificities appear to be detectable only on the same or electrophoretically identical alpha-beta complexes as HLA-DR determinants.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes; D000949:Histocompatibility Antigens Class II / Q000145:classification / Q000235:genetics*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007518:Isoantibodies / Q000276:immunology; D007519:Isoantigens / Q000145:classification / Q000235:genetics*; D002679:Pan troglodytes; D011817:Rabbits; D051381:Rats
D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera; D007518:Isoantibodies; D007519:Isoantigens