Induction of intestinal tumors in rats by dextran sulfate sodium.
The carcinogenicity of dextran sulfate sodium was studied in inbred ACI rats. In group 1, 10 male rats were fed a 10% dextran sulfate sodium diet; in group 2, 14 male and 12 female rats were fed a 5% dextran sulfate sodium diet; and in the control group, 9 male and 9 female rats were given the basal diet without dextran sulfate sodium. After the start of the feeding regimen, all rats given the 10% dextran sulfate sodium diet died of severe diarrhea and anemia within 14 days and 15 of 23 surviving rats fed a 5% dextran sulfate sodium diet developed intestinal tumors between 134 and 215 days. These tumors were induced in the colon and cecum and consisted of adenomas, adenocarcinomas, and papillomas.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D002273:Carcinogens; D002430:Cecal Neoplasms / Q000139:chemically induced; D003110:Colonic Neoplasms / Q000139:chemically induced; D016264:Dextran Sulfate; D003911:Dextrans / Q000633:toxicity*; D004032:Diet; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced*; D051381:Rats; D011912:Rats, Inbred ACI
D002273:Carcinogens; D003911:Dextrans; D016264:Dextran Sulfate