Immunological studies in human ageing. II. Associated increase in anti-RNA and anti-DNA antibodies.
Antibodies against nucleic acids have been studied by counter-immunoelectrophoresis in 95 aged subjects. Increased levels of anti-DNA and/or anti-RNA antibodies were found in 74% of the cases, and immune complexes were detected in 21% of the cases. The increase of anti-DNA antibodies was correlated with that of rheumatoid factor and increased serum IgG levels, whereas the increase of anti-RNA antibodies was associated with decreased serum IgM level and decreased lymphocyte response to PHA.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D000974:Antibodies, Antinuclear / Q000032:analysis; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D004247:DNA / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D012313:RNA / Q000276:immunology*; D012217:Rheumatoid Factor / Q000032:analysis
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010835:Phytohemagglutinins; D012313:RNA; D004247:DNA; D012217:Rheumatoid Factor