Transplantation of unpurged autologous bone-marrow in acute myeloid leukaemia in first remission.
Twelve consecutive patients aged 18-53 were given autologous remission bonemarrow and cyclophosphamide and total-body irradiation to maintain first remission of acute myeloid leukaemia. Follow-up lasted at least 6 months. Seven patients remain in complete unmaintained remission 26-140 weeks post-autograft with overall remissions of 42-202 weeks. The prediction of leukaemia-free survival based on these results is 58% at 3 years. The procedure was well tolerated and resulted in little morbidity and no mortality.
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous; D014916:Whole-Body Irradiation
D003520:Cyclophosphamide