Biochemical controls of liver cholesterol biosynthesis.
Major endogenous regulatory controls of cholesterol synthesis including dietary-feedback inhibition, circadian rhythms, feeding/fasting fluctuations, and enterohepatic bile acid circulation are discussed in terms of biochemical control mechanisms of liver cholesterol biosynthesis. Other likely control mechanisms such as cofactors, enzyme levels, and enzyme activities are noted. The current state of the biochemical knowledge is very dependent upon integrated data from one experimental animal - the rat. Inferences and implications in the human are thus limited.
D000085:Acetates / Q000378:metabolism; D000105:Acetyl Coenzyme A / Q000378:metabolism; D000214:Acyl Coenzyme A / Q000378:metabolism; D000494:Allosteric Regulation / Q000187:drug effects; D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology; D002478:Cells, Cultured; D002784:Cholesterol / Q000096:biosynthesis*; D002791:Cholesterol, Dietary / Q000494:pharmacology; D002940:Circadian Rhythm; D004032:Diet; D011756:Diphosphates / Q000378:metabolism; D004764:Enterohepatic Circulation; D005215:Fasting; D005246:Feedback; D005260:Female; D005502:Food; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D015093:Meglutol / Q000031:analogs & derivatives / Q000378:metabolism; D008798:Mevalonic Acid / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D011973:Receptors, LDL; D013185:Squalene / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology
D000085:Acetates; D000214:Acyl Coenzyme A; D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D011756:Diphosphates; D008077:Lipoproteins, LDL; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; C008047:3-hydroxy-3-methylglutaryl-coenzyme A; D014212:Tretinoin; D000105:Acetyl Coenzyme A; D013185:Squalene; D002784:Cholesterol; D015093:Meglutol; D006903:Hydroxymethylglutaryl CoA Reductases; D008798:Mevalonic Acid