Glutamine-induced alterations in the content of brain amino acid neurotransmitters in rats with different alcohol motivation.
The 10-day administration of glutamine (500 mg/kg per day) with the drinking water to adult albino rats with different alcohol motivation resulted in a significant increase in the content of glutamate, GABA and taurine in the brain. The level of glycine was decreased only in the ethanol-preferring animals. The results obtained are discussed in terms of a possible role of the amino acid neurotransmitters, particularly GABA, in the antialcoholic action of glutamine.
D000428:Alcohol Drinking; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D005973:Glutamine / Q000494:pharmacology*; D009042:Motivation / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D005971:Glutamates; D018377:Neurotransmitter Agents; D005973:Glutamine; D013654:Taurine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid