Relationships between metabolic and hemostatic variables in uncomplicated diabetes.
Several metabolic (HbA1, HDL-C, triglycerides) and hemostatic (VIIIR: Ag, VIII:C, B-TG variables were investigated in 35 non-obese, insulin-dependent diabetics without clinically evident vascular complications. B-TG was high but did not correlate with other metabolic and hemostatic parameters, suggesting that elevated B-TG in diabetes might be an expression of in vitro platelet activation. VIIIR: Ag and the ratio of VIIIR: Ag to VIII: C were markedly increased. There was a significant correlation of the HbA1 and HDL-C levels with VIIIR: Ag, indicating that VIIIR:Ag is another reflection of metabolic control in diabetes. Additional pathogenic mechanisms, however, appear to be involved in causing the changes in VIIIR: Ag in diabetes.
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000032:analysis; D001609:Beta-Globulins / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D003920:Diabetes Mellitus / Q000097:blood*; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood; D001620:beta-Thromboglobulin / Q000032:analysis*; D014841:von Willebrand Factor
D000941:Antigens; D001609:Beta-Globulins; D001779:Blood Coagulation Factors; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D001620:beta-Thromboglobulin; D014841:von Willebrand Factor; D005169:Factor VIII; D006441:Hemoglobin A; D002784:Cholesterol