title: [The plasma turnover of 125I beta 2 microglobulin in healthy humans and patients with renal insufficiency (author's transl)].
abstract: The plasma turnover of 125I beta 2 microglobulin (B2m) was studied in two healthy adults, two anuric patients (one of them without kidneys) and eight patients with various degrees of renal insufficiency. Results were analyzed according to a bicompartmental model. The fractional metabolic rate was positively correlated with inulin clearance, and little (less than 3.5%) extrarenal catabolism was demonstrated. The half-life of B2m in intravascular compartment varied from 107 min in normals to more than 39 hrs in the anephric patient.
mesh_terms: D001609:Beta-Globulins / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
chemical_list: D001609:Beta-Globulins; D001613:beta 2-Microglobulin
vernacular_title: Métabolisme de la beta 2 microglobuline chez l'homme normal et chez l'insuffisant rénal.