Poly(A)-containing RNA in the livers of ethionine-treated rats.
Ethionine intoxication in nonfasted rats leads to a rapid change in the levels of poly(A)+ RNA. Prolonged fasting causes a decrease in poly(A)+ RNA which is not aggravated further by ethionine. The size distribution of poly(A) tracts at the 3' end of mRNA is not affected by ethionine. However, ethionine induces a change in the metabolism of the poly(A) sequence relative to the remainder of the mRNA.
D000225:Adenine / Q000378:metabolism; D000818:Animals; D005001:Ethionine / Q000494:pharmacology*; D005215:Fasting; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009963:Orotic Acid / Q000378:metabolism; D011061:Poly A / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D011061:Poly A; D009963:Orotic Acid; D012313:RNA; D000225:Adenine; D005001:Ethionine