Natural killer cell response to lymphocytic choriomeningitis virus in beige mice.
Lymphocytic choriomeningitis virus (LCMV) induced low levels of natural killer (NK) cell acitivity in C57BL6 mutant beige (bg/bg) mice, which had previously been reported to have no cytotoxic NK cells. NK cell-mediated lysis by bg/bg splenocytes was observed against a cell line (YAC-1) very sensitive to NK cell cytotoxicity, but not appreciably against a less sensitive cell line (L-929). The bg/bg mutant mice with this very low NK cell activity and control strains of mice (by/+, C57BL6) with high NK cell activity synthesized comparable amounts of virus and interferon in the spleen, suggesting that NK cells may not play a significant role, but not appreciably against a less sensitive cell line (L-929). The bg/bg mutant mice with this very low NK cell activity and control strains of mice (by/+, C57BL6) with high NK cell activity synthesized comparable amounts of virus and interferon in the spleen, suggesting that NK cells may not play a significant role, but not appreciably against a less sensitive cell line (L-929). The bg/bg mutant mice with this very low NK cell activity and control strains of mice (by/+, C57BL6) with high NK cell activity synthesized comparable amounts of virus and interferon in the spleen, suggesting that NK cells may not play a significant role in curtailing viral synthesis before the advent of the specific immune response mechanisms.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D007372:Interferons / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008216:Lymphocytic Choriomeningitis / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology*; D010948:Viral Plaque Assay
D007372:Interferons