title: Studies on the biochemistry of the brain during aging.
abstract: There is little doubt that aging changes occur in specific brain cells and neural pathways. Since some of these changes occur in short-lived rodents which probably have no major vascular pathology [48], there may be a general phenomenon of aging in the brain neurotransmitter functions in short- and long-lived mammals. It remains to be discovered how the genome regulates the changes in catecholamine neurotransmitter functions and, further, how these changes relate to normal and pathologic age changes.
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D002395:Catecholamines / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D051381:Rats; D012098:Reproduction
chemical_list: D002395:Catecholamines; D012739:Gonadal Steroid Hormones; D018377:Neurotransmitter Agents; D012333:RNA, Messenger; D012335:RNA, Ribosomal; D012313:RNA