Comparative effects of p-chloroamphetamine and 1-(p-chlorophenyl)piperazine on 5-hydroxyindole concentration in rat brain.
1-(p-Chlorophenyl)piperazine (PCPP), a structural analog of p-chloroamphetamine (PCA), increased serotonin and decreased 5-hydroxyindoleacetic acid (5-HIAA) concentration in rat brain at 6 hours. At one day and one week, serotonin and 5-HIAA concentrations were normal. In contrast, PCA lowered serotonin and 5-HIAA at all three times. These different effects on 5-hydroxyindole concentrations in brain were not due to differences in brain levels of the two compounds, since these were approximately equal. PCPP lacks the ability of PCA to deplete brain 5-hydroxyindoles.
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003864:Depression, Chemical; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013997:Time Factors; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D000662:Amphetamines; D010879:Piperazines; D012701:Serotonin; C026386:1-(4-chlorophenyl)piperazine; D006897:Hydroxyindoleacetic Acid; D010133:p-Chloroamphetamine