title: Effects of beta-adrenoceptor blockade on prostacyclin mediated renin release in sheep.
abstract: The effect of prostacyclin (PGI2) infusion on plasma renin concentration (PRC) was examined before and after propranolol treatment in sheep. Increasing doses of prostacyclin (0.05, 0.1 or 0.3 micrograms/kg per min) produced dose dependent increases in PRC. There was a significantly lower PRC response after propranolol at 0.3 micrograms/kg per min only.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012083:Renin / Q000097:blood* / Q000378:metabolism; D012756:Sheep; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D011464:Epoprostenol; D012083:Renin; D007545:Isoproterenol