Effects of antibodies against nerve growth factor on the postnatal development of substance P-containing sensory neurons.
Administration of anti-nerve growth factor (NGF)-antibodies to newborn rats produces a marked but reversible reduction of the substance P content in dorsal root ganglia. This is in contrast to the effect of anti-NGF-antibodies on sympathetic ganglia, where they cause a destruction of the adrenergic neurons as is evident in the irreversible reduction of tyrosine hydroxylase activity.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D000906:Antibodies / Q000276:immunology*; D005727:Ganglia, Spinal / Q000032:analysis; D009414:Nerve Growth Factors / Q000276:immunology*; D009475:Neurons, Afferent / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000032:analysis; D013373:Substance P / Q000032:analysis / Q000502:physiology*; D013997:Time Factors
D000906:Antibodies; D009414:Nerve Growth Factors; D013373:Substance P