[Serological study of Ia antigens determined at the I-A and I-E sub-regions of the H-E complex in the H-2 complex of mice].
Immune serum B10.S (7R) anti-B10.S (9R)(anti I-JEkCd) contained as expected an anti-Ia7 antibody. A series of weaker but reproducible extra-reactions might recognize Ia3 specificity coded at the I-A subregion of the H-2 complex. Results with recombinant haplotypes confirmed this mapping. Such a reactivity could be interpreted as an interlocus cross-reaction (I-E/I-A) since the immunization was induced against an I-E subregion product. Another interpretation was possible: the immune serum would thus contain an antibody recognizing Ia7 (on the E alpha k Ia chain) and another antibody recognizing an antigenic determinant carried by the E beta k Ia chain. The latter antibody might recognize by cross-reaction as specificity carried by the A beta chain of various haplotypes (H-2b,k,q).
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002874:Chromosome Mapping; D003429:Cross Reactions; D000939:Epitopes; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D051379:Mice
D000939:Epitopes; D006183:H-2 Antigens
Etude sérologique des antigènes Ia déterminés aux sous-régions I-A et I-E du complexe H-E du complexe H-2 de la Souris.