Correlation between postsialographical changes of salivary isoamylase levels in serum and histopathological findings in sublingual glands in patients with Sjögren's syndrome.
Salivary isoamylase values in sera were evaluated before and after sialography in 14 patients with Sjögren's syndrome (SS) and were compared with those in non-SS patients. Non-SS patients consisted of cases of systemic lupus erythematosus, rheumatoid arthritis and ulcerative colitis. In non-SS patients, salivary isoamylase 3 to 6 hours after injection of Conray-400 increased to 2.3 +/- 0.5 fold higher than that prior to the injection and returned to the previous values after 48 hours. On the basis of increases in salivary isoamylase after injection of Conray-400, SS could be divided into three groups: the high response group, the group showing the same values as in non-SS patients and the low response group. The high response group was further classified into two subgroups. Salivary isoamylase before injection in the high response group was higher in patients who showed mild mononuclear cell infiltration histopathologically in their sublingual glands and was lower in patients whose sublingual glands showed diffuse infiltration of mononuclear cells. Mononuclear cells had infiltrated severely in the sublingual glands of patients in the low response group, although they showed salivary isoamylase values before injection within the same ranges as in non-SS patients. These data suggest that both salivary isoamylase before injection and maximum salivary isoamylase increased significantly in cases of mild sialadenitis, the former value decreased with increasing infiltration of mononuclear cells into the sublingual glands, and both values were lower in cases of severe sialadenitis.
D000681:Amylases / Q000097:blood; D006026:Glycoside Hydrolases / Q000097:blood*; D006801:Humans; D007517:Isoamylase / Q000097:blood*; D012463:Saliva / Q000201:enzymology*; D012796:Sialography; D012859:Sjogren's Syndrome / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000473:pathology; D013361:Sublingual Gland / Q000473:pathology*
D000681:Amylases; D006026:Glycoside Hydrolases; D007517:Isoamylase