[Vasoactive peptides in the structure of defensive motivational excitation].
In experiments on rabbits, the action was studied of vasoactive peptides angiotensin-II, bradykinin and lysyl-vasopressin, injected into the brain ventricles, on a passive defensive reaction to electrical stimulation of the ventromedial hypothalamus. It was found that angiotensin-II and lysyl-vasopressin had a pronounced inhibitory influence, while bradykinin had a facilitatory effect on this reaction. Electrical stimulation of the ventromedial hypothalamus predominantly facilitated reactions of individual neurones of the sensorimotor cortex to angiotensin-II and bradykinin. Intraperitoneal injection of P-substance to rats in conditions of an acute conflict situation producing an emotional stress, brought about a significant diminution of sudden death incidence from cardiovascular insufficiency.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001920:Bradykinin / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000139:chemically induced; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects; D008236:Lypressin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013373:Substance P / Q000494:pharmacology
D010455:Peptides; D000804:Angiotensin II; D013373:Substance P; D008236:Lypressin; D001920:Bradykinin
Vazoaktivnye peptidy v strukture oboronitel'nogo motivatsionnogo vozbuzhdeniia.