title: Gametic equilibrium of four loci on chromosome 1.
abstract: The present study is the first to investigate gametic disequilibrium of loosely linked loci (recombination greater than 22%) of known map distance in humans. The study population consisted of 302 healthy unrelated individuals of whit mixed-European ancestry living in the Denver, Colorado area. Pair-wise combinations of four loci on chromosome 1 (Rhesus, Duffy, phosphoglucomutase-1, and amylase-2) were examined for nonrandom association of alleles at different loci. Observed and expected values were compared with chi-square goodness-of-fit tests. There was no evidence of first-order interaction, i.e., gametic disequilibrium. From these findings it seems that gametic disequilibrium may not be important in the genetic organization of chromosome 1.
mesh_terms: D000681:Amylases / Q000235:genetics; D002900:Chromosomes, Human, 1-3 / Q000648:ultrastructure; D004375:Duffy Blood-Group System / Q000235:genetics; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008433:Mathematics; D010179:Pancreas / Q000201:enzymology; D010733:Phosphoglucomutase / Q000235:genetics; D011995:Recombination, Genetic; D012204:Rh-Hr Blood-Group System / Q000235:genetics
chemical_list: D004375:Duffy Blood-Group System; D012204:Rh-Hr Blood-Group System; D000681:Amylases; D010733:Phosphoglucomutase