[Importance of cross-reacting antibodies in creating resistance to influenza].
Hyperimmune rabbit serum to A/PR8/34 virus was analysed by selective adsorption of antibody by viruses belonging to hemagglutinin subtypes H0, H1 and Hsw1. The presence of three antigenic determinants was demonstrated in viral HA: one was common for HA of H0, H1, and Hsw1 viruses, the other was common for HA of H0, H1 and Hsw1 viruses, and the third was strain-specific for this virus. The protective effect of formalin-inactivated influenza vaccines prepared from virus variants with H0 and H1 hemagglutinins against challenge with A/PR8/34 virus was studied. The presence in the vaccine influenza virus of at least one antigenic determinant common with that of the challenge virus was shown to create a certain degree of protection in mice against influenza. The presence of two antigenic determinants in HA of vaccine and challenge virus increased considerably the protective effect of the vaccine.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000914:Antibodies, Viral / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis; D007106:Immune Sera / Q000302:isolation & purification; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D011817:Rabbits
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D000939:Epitopes; D007106:Immune Sera; D007252:Influenza Vaccines
Znachenie perekrestno reagiruiushchikh antitel v sozdanii rzistentnosti k grippoznoĭ infektsii.