Mechanism of action of antiviral hetarylhydrazones in vitro.
Three antiviral hetarylhydrazones showed a depression of 3H-uridine incorporation into RNA of FL cells as a consequence of inhibition of uridine transport into the cells. By eliminating the action of the compounds on transport processes with the prelabelling method, only one compound showed a nearly 50% reduction of cellular RNA synthesis during the whole incubation period, whereas the other two compounds had no influence during the first 6 hr. Under prelabelling conditions all three compounds completely inhibited the synthesis of Mengo virus RNA. One compound did not affect cellular DNA synthesis, but presumably depressed thymidine transport into the cells.
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D006835:Hydrazones / Q000494:pharmacology*; D007739:L Cells; D008574:Mengovirus / Q000187:drug effects* / Q000378:metabolism; D010080:Oxazoles / Q000031:analogs & derivatives / Q000494:pharmacology*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012367:RNA, Viral / Q000096:biosynthesis
D000998:Antiviral Agents; D006835:Hydrazones; D010080:Oxazoles; D012367:RNA, Viral; C016864:IMET 98-69; C030528:Z 124-73; C030527:ZIMET 38-74; D012313:RNA; D004247:DNA