Carrier and hapten functions in immune deviation. III. Possible antigenic competition between hapten and carrier determinants at the macrophage level.
The effects of the intravenous injection of DNP-Ficoll on delayed hypersensitivity reactions to bovine gamma globulins (BGG) and anaphylactic reactions to the hapten induced by immunization with DNP-BGG in Freund's adjuvant were studied in guinea pigs. Animals treated with DNP-Ficoll exhibited stronger delayed hypersensitivity to BGG and lower anaphylactic reactions to the hapten than control animals treated with saline, Ficoll alone or with an unrelated protein antigen. These results could be explained by antigen competition between hapten and carrier determinants occurring at the macrophage level.
D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000276:immunology*; D002417:Cattle; D004136:Dinitrobenzenes / Q000276:immunology; D000939:Epitopes; D005260:Female; D005362:Ficoll / Q000276:immunology; D006168:Guinea Pigs; D006241:Haptens / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology
D002352:Carrier Proteins; D004136:Dinitrobenzenes; D000939:Epitopes; D006241:Haptens; D005719:gamma-Globulins; D005362:Ficoll