Detection of the leukocyte group-5 antigens on normal and leukemic lymphocytes with the antibody-dependent cell-mediated cytotoxicity assay.
We have found that the antibody-dependent call-mediated cytotoxicity (ADCC) assay is capable of detecting the alleles of the group-5 antigenic system on peripheral blood lymphocytes. This finding should facilitate additional study of this system, as illustrated by the detection of group-5 antigens on leukemic cells, indicating that they are not lost from the cell surface upon malignant transformation.
D000372:Agglutination Tests; D000483:Alleles; D000920:Antibody-Dependent Cell Cytotoxicity; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*
D000939:Epitopes; D006680:HLA Antigens