[Effect of pretreatment with isoprenaline on functional and metabolic characteristics of isolated rat heart].
Mechanical performance and tissue content of high-energy phosphates were studied in working rat hearts, isolated from normal rats, or from daily subcutaneously injected with isoproterenol for one day or seven days (5 mg/kg b.w.) and atrially perfused. Isoproterenol pretreatment led to a significant decrease in myocardial content of ATP, ADP. After 75-min perfusion, the content of ATP, ADP, AMP and CP was significantly lower in pretreated hearts than in untreated. On the other hand, isoproterenol-treated hearts exhibited higher aortic pressure, oxygen consumption, left ventricular systolic pressure and d (L.V.P.) max/dt and heart work. It is suggested from these findings that isoproterenol pretreatment of rats improve cardiac work and decrease efficiency in ISO.24 h group and improve cardiac work and efficiency in ISO.7 days group.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats
D000227:Adenine Nucleotides; D010725:Phosphocreatine; D007545:Isoproterenol
Effet d'un prétraitement à l'isoprénaline sur les caractéristiques fonctionnelles et métaboliques du coeur isolé de rat.