HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression.
A new human erythroleukemia cell line has been established. This line, designated HEL, is capable of spontaneous and induced globin synthesis, producing mainly G gamma and A gamma chains. Embryonic chains (epsilon, zeta) and alpha chains are detectable in very small amounts; beta chains are undetectable. This line provides a new model system for studying aspects of erythroid cell differentiation and differential globin gene expression.
D002460:Cell Line; D005319:Fetal Hemoglobin / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D005914:Globins / Q000096:biosynthesis* / Q000235:genetics; D006427:Hemin / Q000494:pharmacology; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000378:metabolism
D006427:Hemin; D005914:Globins; D005319:Fetal Hemoglobin