[Discovery of a unique strain-specific idiotypic antigenic determinant of mouse T-lymphocyte antigen-recognizing receptors].
The cellular radioimmunoassay using rabbit anti-CBA-anti-C57BL/6 antiidiotypic serum was performed to detect a private strain-specific antigenic idiotypic determinant (s) on activated CBA-anti-C57BL/6 T cells. This private idiotype was not expressed on other activated T cells under study: CBA-anti-BALB/C; C3H-anti-C57BL/6; AKR-anti-C57BL/6; A/Sn-anti-C57BL/6; BALB/C-anti-C57BL/6; DBA/2-anti-C57BL/6. It is suggested that gene (s) coding the private strain-specific idiotypic antigenic determinant of the antigen-recognition receptor of T cells is not localized on the H-2 complex of mice.
D000818:Animals; D000939:Epitopes / Q000302:isolation & purification*; D007130:Immunoglobulin Idiotypes / Q000302:isolation & purification*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits; D011863:Radioimmunoassay / Q000379:methods; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013045:Species Specificity
D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D011948:Receptors, Antigen, T-Cell
Obnaruzhenie unikal'noĭ lineĭno-spetsificheskoĭ idiotipicheskoĭ antigennoĭ determinaty antigenraspoznaiushchikh retseptorov T-limfotsitov mysheĭ.