Autoantibodies specific to beta-2-microglobulin inhibit the Fc receptor-dependent phagocytosis of human monocytes.
Effect of anti-beta2-microglobulin (beta2m) antibodies was investigated on the in vitro Fc and C3 receptor dependent phagocytic capacity of human peripheral monocytes. Both rabbit and human anti-beta2m antibodies inhibit the Fc receptor-mediated phagocytosis. Anti-beta2m antibodies do not influence the spontaneous or C3b receptor-mediated ingestion. The inhibitory activity by human autoantibodies but not by rabbit anti-human beta2m antibodies was diminished when incubation was performed at 37 degrees C instead of 20 degrees C.
D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies; D001609:Beta-Globulins / Q000276:immunology*; D003176:Complement C3; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007074:Immunoglobulin G; D009000:Monocytes / Q000276:immunology*; D010587:Phagocytosis; D011817:Rabbits; D011961:Receptors, Fc; D015002:Yeast, Dried / Q000276:immunology; D001613:beta 2-Microglobulin / Q000276:immunology*
D001323:Autoantibodies; D001609:Beta-Globulins; D003176:Complement C3; D007074:Immunoglobulin G; D011961:Receptors, Fc; D001613:beta 2-Microglobulin