Fragments of prosomatostatin isolated from a human pancreatic tumour.
Six peptides from an extract of a human pancreatic tumour were purified to homogeneity by HPLC. Amino acid composition and chemical properties indicated probable structures the same as somatostatin-14, somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-12), [Met(O)8]somatostatin-28 (1-10), somatostatin-25 (1-9) and [Met(O)5]somatostatin-25 (1-9). The structure of somatostatin-14 was confirmed by sequence analysis. The isolation of these peptides provides insight into the processing of prosomatostatin in the tumour cells.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010084:Oxidation-Reduction; D010190:Pancreatic Neoplasms / Q000032:analysis*; D010446:Peptide Fragments / Q000302:isolation & purification*; D011498:Protein Precursors / Q000302:isolation & purification*; D013004:Somatostatin / Q000302:isolation & purification*; D053561:Somatostatin-28
D000596:Amino Acids; D010446:Peptide Fragments; D011498:Protein Precursors; D013004:Somatostatin; C028456:prosomatostatin; D053561:Somatostatin-28; C037197:somatostatin 28-(1-12); C044224:somatostatin 25-(1-9)