Association of minimal change nephrotic syndrome (MCNS) with HLA-B8 an B13.
HLA antigens of 45 children with idiopathic nephrotic syndrome were typed for 26 phenotypic specificities. A significant association of MCNS with HLA-B 8 and B 13 was found. There was also a significantly increased frequency of the antigen combination HLA-A 1/B 8 (most presumably the haplo-type). The association with HLA-B 8 provides further evidence of an important role of immune mechanisms in the pathogenesis of MCNS.
D002648:Child; D000939:Epitopes / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D015235:HLA-B Antigens; D006801:Humans; D009404:Nephrotic Syndrome / Q000276:immunology*
D000939:Epitopes; D006680:HLA Antigens; D015235:HLA-B Antigens