Beta-adrenergic drug induced hyperplasia in the immature rat parotid and submandibular glands.
In this study the proliferative response of rat parotid (PRG) and submandibular (SMG) gland acinar cells to beta-adrenergic stimulation with Isoproterenol (a non-selective beta-agonist) or terbutaline (a relatively selective beta 2-agonist) was determined during the 4th-5th postnatal weeks in intact and guanethidine-sympathectomized (Sx) rats. Rats were divided into 2 age groups (21 and 28 days) and 6 experimental groups (control-intact (C), guanethidine-treated (Sx), intact + TER (C + TER), intact + Isoproterenol (C + IPR), guanethidine-treated + TER (Sx + TER), and guanethidine-treated + isoproterenol (Sx + IPR]. Intact and Sx rats were treated with either IPR or TER for 3 days (days 21, 22, and 23 or days 28, 29 and 30). On day 24 or 31 all rats were injected with [3H]-thymidine and killed 1 h later. PRG of Sx and C + TER rats showed no significant differences from controls in wet weight while SMG from Sx rats demonstrated a reduced wet weight compared to C rats. [3H]Thymidine labelling index and mitotic index were not significantly different in Sx and C + TER rats in either PRG or SMG. C + IPR rats showed increased wet weight, labelling and mitotic index compared to controls (P less than 0.01). Sx + IPR increased values over controls (P less than 0.01) and above C + IPR values (P less than 0.01). Sx + TER values were significantly higher than controls.(ABSTRACT TRUNCATED AT 250 WORDS)
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division; D005260:Female; D006965:Hyperplasia; D007545:Isoproterenol / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010306:Parotid Gland / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D013363:Submandibular Gland / Q000187:drug effects* / Q000473:pathology; D013562:Sympathectomy; D013726:Terbutaline / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; D013726:Terbutaline