title: Ketoconazole in Trichophyton rubrum.
abstract: 10 patients with T. rubrum infection were treated with Ketoconazole 200-400 mg a day for 8 weeks. All patients had a skin infection and 2 in addition infection of the toe nails. Previous treatment with Griseofulvin and at least two different antifungal topicals had been ineffective. The infection was evaluated by clinical findings and mycological examination. The skin lesions disappeared in 6 patients, while none of the nail lesions were cured. However, at a follow-up 2 months after the end of the Ketonocazole treatment, recurrence was observed in 3 of 6 patients. It is suggested that Ketoconazole treatment of previously resistant T. rubrum infection should be continued for more than 2 months.
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007654:Ketoconazole; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D014005:Tinea / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D007654:Ketoconazole