Recent studies on antibiotics and small molecular immunomodulators with potential usefulness in treating lung cancer: Part I - Antitumor antibiotics and their derivatives.
Aclacinomycin, isolated from the culture of a Streptomyces, and 4'-O-tetrahydropyranyladriamycin, prepared by chemical derivation, exhibit significantly low cardiac toxicity and more effectiveness than does adriamycin. Pepleomycin, a new derivative of bleomycin, has 4-5 times lower pulmonary toxicity and more potent activity than the parent antibiotic. The future prospects of studies on antibiotics with potential usefulness in treatment of lung cancer are discussed.
D015250:Aclarubicin / Q000031:analogs & derivatives*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology; D003630:Daunorubicin / Q000494:pharmacology; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D008168:Lung / Q000187:drug effects*; D008175:Lung Neoplasms / Q000188:drug therapy*; D051379:Mice; D008970:Molecular Weight; D009279:Naphthacenes / Q000494:pharmacology; D017663:Peplomycin; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C011157:aclacinomycins; D001761:Bleomycin; D017663:Peplomycin; D015250:Aclarubicin; D004317:Doxorubicin; C027260:pirarubicin; D003630:Daunorubicin