Early and late systemic effects of colchicine on muscle permeability to inorganic phosphate.
A single systemic injection of 75 micrograms colchicine/100 g body weight in the lumbar muscles increases within 6 h the permeability of the extensor digitorum longus muscle to inorganic phosphate. Twenty four hours after the injection the specific activities and isotope uptakes of both inorganic and organic-bound acid-soluble phosphates are markedly increased. By the third day a maximal four-fold increase in rate of inorganic phosphate exchange is reached. The observed effects are slowly reversible, a near normal situation obtaining after 30 days. They are qualitatively different from those observed after administration of vincristine sulphate and bupivacaïne (Marcaine).
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D010539:Permeability; D010710:Phosphates / Q000378:metabolism*; D051381:Rats
D010710:Phosphates; D003078:Colchicine