Recent studies on 'hyalinized' glomeruli.
Hyalinized glomeruli in tissue sections those isolated from kidneys of subjected with end-stage and diabetic nephropathies and from aged persons (older than 75 years) were studied by histochemical, immunohistochemical, electron microscopic, and chemical methods. Our purposes were as follows: (1) to clarify the pathogenic mechanisms of glomerular hyalinization; (2) to resolve some of the controversies on terminology in the literature. Results showed significant increases in the amounts of collagen (13% to 30%), carbohydrates (30% to 47%), and lipids (58% to 82%), and decreases in the amounts of DNA (40%) and RNA (40% to 50%) in the hyalinized glomeruli of diseases compared with normally sized matched glomeruli. I conclude that glomerular hyalinization is a complex molecular pathogenic process.
D000368:Aged; D002241:Carbohydrates / Q000032:analysis; D003094:Collagen / Q000032:analysis; D004247:DNA / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006652:Histological Techniques; D006801:Humans; D006818:Hyalin / Q000032:analysis* / Q000166:cytology / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008055:Lipids / Q000032:analysis; D008854:Microscopy, Electron; D009929:Organ Size; D012313:RNA / Q000032:analysis; D013997:Time Factors
D002241:Carbohydrates; D007136:Immunoglobulins; D008055:Lipids; D012313:RNA; D003094:Collagen; D004247:DNA