Adrenaline and the development of genetic hypertension.
The effects, on the development of a raised blood pressure in spontaneously hypertensive (SHR) rats, of bilateral adrenal demedullation and subcutaneous slow-release implants containing adrenaline, salbutamol and procaterol were studied. Systolic blood pressure (SBP) measurements were made, using an indirect tail-cuff method in groups of male SHR rats aged from three to 14 weeks, which were sham-operated or bilaterally adrenal demedullated under ether anaesthesia at four weeks of age. Bilateral adrenal demedullation attenuated the development of a raised blood pressure, while slow-release implants of adrenaline restored the development of hypertension in adrenal demedullated rats and this effect was abolished by concomitant treatment with the beta 2-adrenoceptor antagonist [C] 118551. Implants of salbutamol and procaterol were also effective in restoring hypertension development in adrenal demedullated rats. It is suggested that adrenaline exerts its pro-hypertensive effects via an action at beta 2-adrenoceptors; possibly those located prejunctionally which are involved in the facilitation of sympathetic neurotransmission.
D000313:Adrenal Medulla / Q000502:physiology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D004343:Drug Implants; D004837:Epinephrine / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D051379:Mice; D017265:Procaterol; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D003692:Delayed-Action Preparations; D004343:Drug Implants; D004983:Ethanolamines; D011412:Propanolamines; C026777:ICI 118551; D000420:Albuterol; D017265:Procaterol; D004837:Epinephrine