Dose-response studies with pancuronium, vecuronium and their combination.
Pancuronium, vecuronium and a combination of these were administered in an incremental fashion to study any potentiation of effect with the combination of the two relaxants. The ED95 (dose producing a 95% block) of the combination was 29 micrograms kg-1 for each component in comparison to 57 micrograms kg-1 for vecuronium and 59 micrograms kg-1 for pancuronium. The dose-response curves for the three groups did not differ from each other and no potentiation was demonstrated.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009411:Nerve Endings / Q000187:drug effects; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014673:Vecuronium Bromide
D004338:Drug Combinations; D014673:Vecuronium Bromide; D010197:Pancuronium