Relationship between the cellular expression of the antiviral and anticellular activities of interferon.
This study suggests that the expression of the antiviral and anticellular activities of interferon in rat cells treated with homologous interferon are closely linked. After addition and subsequent removal of interferon, the two activities appeared and disappeared simultaneously. Both activities were equally influenced by the exposure time and by the temperature during exposure to interferon. Pretreatment of the cells with cholera toxin inhibited both activities to the same extent at low interferon levels.
D000818:Animals; D000998:Antiviral Agents; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002772:Cholera Toxin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007372:Interferons / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007700:Kinetics; D051381:Rats; D013696:Temperature; D013997:Time Factors
D000998:Antiviral Agents; D007372:Interferons; D002772:Cholera Toxin