Influence of histamine or dimaprit on histamine release induced by anti-ige from human whole blood.
In human subjects histamine release from whole blood by anti-IgE and studied under several concentrations of histamine and dimaprit. The results obtained in our experiments led us to question the autoregulatory feed-back mechanism postulated by BOURNE et al. [1]. Apparently this mechanism does not apply for all patients particularly at doses which resemble physiological concentrations of histamine.
D000906:Antibodies; D017259:Dimaprit; D006632:Histamine / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013890:Thiourea / Q000494:pharmacology*
D000906:Antibodies; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D007073:Immunoglobulin E; D006632:Histamine; D013890:Thiourea; D017259:Dimaprit