Immunology of sarcomas.
There is evidence for common sarcoma antigens expressed on a variety of sarcomas of bone and soft tissues. Antibodies and cell-mediated responses to sarcoma-associated if not sarcoma-specific antigens have been demonstrated in tumor-bearing patients. Antibodies have also been found in contacts and parents of affected individuals. Common antigenicity and a response to sarcoma antigens by ostensibly normal individuals provide circumstantial evidence for a viral etiology, supported by experiments inducing sarcomas with known viruses in rodents. Immunotherapy that takes advantage of the immunogenicity of sarcomas is in its infancy, but has significant promise.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D001859:Bone Neoplasms / Q000276:immunology*; D000939:Epitopes; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D009858:Oncogenic Viruses; D012516:Osteosarcoma / Q000276:immunology; D012509:Sarcoma / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000276:immunology; D012983:Soft Tissue Neoplasms / Q000276:immunology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D000939:Epitopes