Effect of dopaminergic agents on levels of dynorphin1-8 in rat striatum.
In this study, the possibility that striatal dynorphin1-8 levels would be altered by either acute or chronic treatment with dopaminergic agonists or antagonists is examined. Animals were treated chronically (3 weeks) with daily injections of d-amphetamine, phencyclidine or haloperidol. For the acute studies, animals were given a single dose of either d-amphetamine or haloperidol. Dynorphin1-8 levels were estimated using a radioimmunoassay. Only chronic treatment with d-amphetamine has any effect on dynorphin1-8 levels. Following 3 weeks of chronic d-amphetamine, the level of dynorphin1-8 increased in 2 separate experiments. Acute d-amphetamine or haloperidol treatment or chronic haloperidol or phencyclidine treatment had no effect on striatal dynorphin1-8 levels. However, chronic (but not acute) d-amphetamine administration does produce a small increase in striatal dynorphin1-8 levels.
D000818:Animals; D003342:Corpus Striatum / Q000032:analysis*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004399:Dynorphins / Q000032:analysis*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D010622:Phencyclidine / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D004399:Dynorphins; D010622:Phencyclidine; D006220:Haloperidol; D003913:Dextroamphetamine