The viability of transplants of mesencephalic raphe nuclei in the IVth ventricle of the adult rat.
Mesencephalic raphe nuclei were transplanted via the cisterna magna near the locus coeruleus. The transplants were observed at different time intervals ranging from 24 h to 4 months. Microscopic observations revealed that from 3 weeks to 4 months the transplant developed with a well-defined neural organization. Radioautographic results showed that some of the neurons in the implant at 3 weeks captured and retained [3H] serotonin. These results indicate that the intact IVth ventricle seems to be a likely culturing floor for mesencephalic raphe nuclei.
D000818:Animals; D001370:Axonal Transport; D001933:Brain Stem / Q000637:transplantation*; D002552:Cerebral Ventricles / Q000502:physiology*; D007700:Kinetics; D008636:Mesencephalon / Q000502:physiology / Q000637:transplantation*; D009474:Neurons / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D012701:Serotonin