Inhibitory activity of 2-aminooxazole derivatives against Coxsackie B1 virus in FL cells.
The antiviral activity of three-2-aminooxazoles was studied against coxsackie B1 virus in FL cells. The virus-induced cytopathic effect was nearly completely suppressed by two of the test compounds as revealed by spectrophotometric turbidity measurements. The plaque reduction amounted to 95--100 per cent. The compounds had no effect on extracellular virus or on absorption and penetration. The inhibition of infectious virus yield in one-step growth experiments reached 94--99.9 per cent. One of the compounds showed no inhibition of cellular RNA synthesis, whereas viral RNA synthesis was completely suppressed. The other two exerted only a small influence on cellular RNA synthesis. However, the results suggested an inhibition of uridine transport.
D000650:Amnion; D000998:Antiviral Agents; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D029822:Enterovirus B, Human / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D010080:Oxazoles / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D012367:RNA, Viral / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects
C027021:2-guanidino-4,5-di(n-propyl)oxazole; C027019:2-guanidino-4,5-diphenyloxazole; D000998:Antiviral Agents; D010080:Oxazoles; D012367:RNA, Viral; C027022:2-amino-4,5-diphenyloxazole; D012313:RNA