[Effect of obzidan, tropaphen, adrenaline and euphylline on histamine bronchospasm in guinea pigs].
It has been demonstrated in experiments on guinea-pigs that the beta-adrenoblocker propranolol (1-2 mg/kg) substantially raises bronchial sensitivity to histamine (10 mg/kg). The alpha-adrenoblocker tropaphen (2 mg/kg) potentiates the protective action of adrenaline (5 micrograms/kg) and euphylline (8 mg/kg) in bronchospasm induced by histamine (10 micrograms/kg).
D000317:Adrenergic alpha-Antagonists / Q000633:toxicity*; D000628:Aminophylline / Q000627:therapeutic use*; D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000627:therapeutic use*; D006168:Guinea Pigs; D006632:Histamine / Q000633:toxicity*; D011433:Propranolol / Q000633:toxicity*; D014326:Tropanes / Q000633:toxicity*
D000317:Adrenergic alpha-Antagonists; D014326:Tropanes; D000628:Aminophylline; C009599:tropodifene; D006632:Histamine; D011433:Propranolol; D004837:Epinephrine
Vliianie obzidana, tropafena, adrenalina i éufillina na gistaminovyĭ bronkhospazm u morskikh svinok.