IgA-dependent, monocyte-mediated, antibacterial activity.
IgA purified from the sera of patients convalescing from disseminated group C meningococcal disease induced human monocyte-mediated anti-meningococcal activity in vitro in the absence of complement. Both IgA- and IgG-dependent activity were directed against the group C meningococcal polysaccharide (Csss) capsule. The amount of IgA that was effective bound less than 1 ng of Csss. Antibacterial activity was dependent upon the length and the temperature of the test incubation and on the concentration of monocytes. The implications of this mechanism for local cell-mediated antibacterial immunity are discussed.
D000920:Antibody-Dependent Cell Cytotoxicity; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D009345:Neisseria meningitidis / Q000187:drug effects / Q000276:immunology*; D013696:Temperature; D013997:Time Factors
D000939:Epitopes; D007070:Immunoglobulin A