title: On the mechanism of variation of pancreatic amylase levels in mouse strains.
abstract: The relative levels of pancreatic amylase mRNA closely parallel the 3-fold variation of pancreatic amylase protein levels observed in several mouse strains studied. In contrast pancreatic elastase mRNA levels were similar in these strains. Each of the strains contained the same number of amylase-like genes (about 8). The selective variation in the pancreatic amylase gene expression could be due either to differences in the numbers of active amylase genes or to different rates of synthesis and/or degradation of the amylase mRNA from a constant number of genes.
mesh_terms: D000681:Amylases / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D004247:DNA; D004262:DNA Restriction Enzymes; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats
chemical_list: D007527:Isoenzymes; D012333:RNA, Messenger; D004247:DNA; D004262:DNA Restriction Enzymes; D000681:Amylases; D010196:Pancreatic Elastase