Cutaneous T cell lymphoma: characterization by monoclonal antibodies.
Monoclonal antibodies to human T cells permit the characterization of the surface phenotype of cutaneous T cell lymphoma (CTCL). The majority of CTCL cells are reactive with OKT1 and OKT3 monoclonals, which identify peripheral T cells and mature thymocytes. The neoplastic cells also react with OKT4, which recognizes the inducer T cell subset; they are, however, unreactive with OKT5 monoclonal, which identifies cytotoxic/suppressor T cell subsets. These data are in agreement with previous functional studies demonstrating that CTCL is a neoplasm of inducer (helper) T cells.
D000918:Antibody Specificity; D000954:Antigens, Surface; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D000939:Epitopes