Failure to produce axon reflex-sweating in the volar skin of Japanese monkey (Macaca fuscata) and crab-eating monkey (Macaca irus).
The functional properties of the sweat glands and their innervation in the volar skin of three Japanese monkeys and two crab-eating monkeys were investigated. The sweat glands responded to both cholinomimetic and adrenomimetic agents, the former being highly predominant in the sudorific effect. Spontaneous emotional sweating was strongly or completely inhibited by atropine at 10(-8)-10(-7) g/ml, but not by dihydroergotamine at 10(-5)-10(-4) g/ml. Axon reflex sweating could not be produced by nicotine at 10(-5)-10(-4) g/ml in all of primates tested. The nerve fibers surrounding the sweat glands were histochemically confirmed to contain both acetyl- and butyrylcholinesterase.
D000109:Acetylcholine / Q000494:pharmacology; D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000201:enzymology / Q000502:physiology*; D002091:Butyrylcholinesterase / Q000378:metabolism; D002217:Carbachol / Q000494:pharmacology; D002802:Cholinesterases / Q000378:metabolism; D005260:Female; D008251:Macaca; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D012018:Reflex; D012867:Skin / Q000294:innervation*; D013045:Species Specificity; D013545:Sweat Glands / Q000187:drug effects; D013546:Sweating / Q000187:drug effects
D002217:Carbachol; D010830:Physostigmine; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D000109:Acetylcholine