[Degenerative changes in cerebrospinal fluid electrophoresis recordings during spinocerebellar hereditary degenerative disorders. A study of 111 cases (author's transl)].
The authors describe the results of electrophoresis studies of 111 cerebrospinal fluids from 110 patients with various spinocerebellar degenerative diseases (58 cases of Friedreich's disease, 14 of Pierre-Marie's ataxia, 12 of Strumpell-Lorrain paraplegia, 23 cerebellar atrophies, and 4 cases of Roussy-Levy disease). The degenerative profile of the electrophoresis findings were characterized by an overall reduction in CSF proteins, an increase in pre-albumin, and a reduction in gammaglobulin, and this was noted in 82 cases (73.8 p. 100). Low levels (less than or equal to 0.17 g/l) of proteins were observed in 19 cases (17.1 p. 100), and increased pre-albumin in 43 cases (38.7 p. 100). Reduced gammaglobulin was present in 20 cases (18.0 p. 100), and the cerebrospinal fluid was normal in only 29 cases (26.1 p. 100). These modifications could result from a particular type of physiopathological process of cell degeneration in the nervous system.
D001284:Atrophy / Q000134:cerebrospinal fluid; D002524:Cerebellar Ataxia / Q000134:cerebrospinal fluid*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D004587:Electrophoresis, Agar Gel; D004588:Electrophoresis, Cellulose Acetate; D005621:Friedreich Ataxia / Q000134:cerebrospinal fluid; D006801:Humans; D010264:Paraplegia / Q000134:cerebrospinal fluid; D011228:Prealbumin / Q000134:cerebrospinal fluid; D005719:gamma-Globulins / Q000134:cerebrospinal fluid
D002556:Cerebrospinal Fluid Proteins; D011228:Prealbumin; D005719:gamma-Globulins
Electrophorèse du liquide céphalo-rachidien au cours des hérédodégénérescences spino-cérébelleuses. Etude de 111 observations.