Behaviour in biotin-deficient rats of thymic peptides controlling DNA transcription.
Biotin-deficient rats show a slowing down of the growth and an involution of the thymus. The amount of the thymic peptides controlling DNA template, if referred to the thymus weight is higher in deficient than in control rats; no significant difference is noticed among the contents of the active peptides when evaluated per rat. The inhibiting activity on RNA synthesis is the same for the peptides extracted from normal and from biotin-deficient rat thymus.
D000818:Animals; D001710:Biotin / Q000172:deficiency*; D001835:Body Weight; D005260:Female; D009929:Organ Size; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013950:Thymus Gland / Q000503:physiopathology*; D014158:Transcription, Genetic / Q000187:drug effects*
D010455:Peptides; D012313:RNA; D001710:Biotin