title: A comparison in germ-free mice of the pathogenesis of Sendai virus and mouse pneumonia virus infections.
abstract: The poathogenesis of Sendai virus and pneumonia virus of mice (PVM) was studied using the immunoperoxidase technique on paraffin lung sections. The pathology of Sendai virus corresponds to that of a bronchopneumonia, with virus demonstrated by immunoperoxidase in the bronchial epithelium, and sometimes in macrophages, for a period of 2--9 days post-infection. Pneumonia virus of mice produces an interstitial pneumonia with virus demonstrated in the bronchial epithelium but also in the alveolar walls and alveolar macrophages. This virus can be demonstrated between 2 and 7 days post-infection. This technique was used to demonstrate PVM in the case of a natural outbreak of this disease and may eventually become a routine technique for the screening of lung tissue for respiratory viruses.
mesh_terms: D000818:Animals; D001980:Bronchi / Q000473:pathology; D004801:Eosine Yellowish-(YS); D005856:Germ-Free Life; D006416:Hematoxylin; D007124:Immunoenzyme Techniques; D008168:Lung / Q000473:pathology*; D051379:Mice; D010222:Parainfluenza Virus 1, Human; D018184:Paramyxoviridae Infections / Q000473:pathology*; D011024:Pneumonia, Viral / Q000473:pathology*; D013997:Time Factors
chemical_list: D004801:Eosine Yellowish-(YS); D006416:Hematoxylin