title: [Comparative study of the effect of famotidine and cimetidine on antipyrine pharmacokinetics in the human].
abstract: In a randomized order the pharmacokinetics of antipyrine were studied following a 5 days treatment period with placebo, 1000 mg cimetidine and 40 mg famotidine daily, respectively in 7 healthy volunteers. In contrast to cimetidine, famotidine did not significantly affect the disposition of antipyrine in these subjects. Famotidine like the other guanidino-thiazole containing compound tiotidine appears to be free from this unwanted effect on drug metabolism in the liver.
mesh_terms: D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D002927:Cimetidine / Q000494:pharmacology*; D015738:Famotidine; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D006634:Histamine H1 Antagonists; D013844:Thiazoles; D015738:Famotidine; D002927:Cimetidine; D000983:Antipyrine
vernacular_title: Vergleichende Untersuchungen über den Einfluss von Famotidin und Cimetidin auf die Antipyrin-Pharmakokinetik beim Menschen.