title: Site of action of N,N'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine in the vaccinia virus replication cycle.
abstract: N,N'-Bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine inhibits late function or synthesis of a late component in the replication cycle of vaccinia virus. The kinetics of formation of the component sensitive to the inhibition with N,N'-bis(methylisatin-beta-thiosemicarbazone)-2-methylpiperazine precedes that of appearance of infectious virus by 30 min. The finding is in accord with the site of action of unsubstituted isatin-beta-thiosemicarbazone.
mesh_terms: D000998:Antiviral Agents; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008720:Methisazone / Q000031:analogs & derivatives / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D013882:Thiosemicarbazones; C023484:TSKI-VI; D008720:Methisazone