title: [Replication and transcription in Drosophila cells treated with novobiocin].
abstract: The effect of novobiocin on replication and transcription in the cells of Drosophila was investigated by incorporation of 3H-thymidine and 3H-uridine into the diploid cell nuclei of the ganglia and imaginal discs, as well as into the polythene nuclei of the salivary gland cells of the Drosophila larvae. An inhibitory effect of the antibiotic on these processes was shown. Possible mechanisms of the novobiocin effect on DNA and RNA synthesis are discussed.
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects*; D004171:Diploidy; D004331:Drosophila melanogaster / Q000187:drug effects; D007814:Larva / Q000187:drug effects; D009675:Novobiocin / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D009675:Novobiocin; D012313:RNA; D004247:DNA
vernacular_title: Replikatsiia i transkriptsiia v kletkakh drozofily, obrabotannykh novobiotsinom.