[The effect of substance P on the regeneration of nerve fibres in vitro (author's transl)].
Explants of the ganglion trigeminale from chick embryos (PNS) and of the hippocampus from fetal rats (CNS) were cultivated in maximow chambers in the presence of synthetic substance P (SP). SP Stimulated the outgrowth of neuronal processes in PNS-culture. In SP-treated CNS cultures a stimulation was not observed. The density of SP-treated medio-dorsal neuroblasts decreased. The possible role of SP as a system in controlling in-vitro-processes of nerve fibre regeneration is discussed.
D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D005333:Fetus; D009412:Nerve Fibers / Q000187:drug effects* / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000187:drug effects*; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D013373:Substance P / Q000494:pharmacology*; D012668:Trigeminal Ganglion / Q000166:cytology
D013373:Substance P
Uber die Wirkung von Substanz P auf das Wachstum von Nervenfasern unter In-vitro-Bedingungen.