[The use of midodrin in the treatment of the orthostatic syndrome (author's transl)].
Midodrin, a new alpha-mimetic drug, has been studied with respect to its therapeutic effectiveness in children suffering from orthostatic hypotension. The study was carried out as a double blind trial against placebo. A statistically significant improvement was found only in relation to the following symptoms: "tendency to collapse", "dizziness", "headache", "change of colour". Blood pressure- and ECG alterations within the framework of the Schellong orthostatic and functional test were not significantly different statistically. This might be due to the small number of patients examined, to a placebo-effect or perhaps due to the inconsistent findings inherent in this last test.
D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004983:Ethanolamines / Q000627:therapeutic use*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy* / Q000503:physiopathology; D008879:Midodrine / Q000009:adverse effects / Q000627:therapeutic use*
D004983:Ethanolamines; D008879:Midodrine
Die Behandlung des Orthostasesyndroms mit Midodrin. Eine klinische Prüfung seiner Wirksamkeit mit Hilfe des Orthostaseversuches im Doppelblindverfahren.