Maldescended testes and fertility: a review of 68 cases.
We report an analysis of 68 of 1112 couples who attended an infertility clinic where the man had past or present evidence of testis maldescent. The age at orchiopexy for these 68 men was later than would be expected, taking into account surgical practice in Scotland for the relevant time period and this supports the view that late orchiopexy is a risk factor for subsequent infertility. There was no evidence that antisperm antibodies are responsible for the damage to spermatogenesis in unilateral cases; however, measurement of the serum hormones showed elevations of LH and FSH which cannot be entirely explained as secondary to the damaged spermatogenesis. There was weak but nevertheless significant evidence that testis maldescent may be a poor prognostic factor as far as subsequent fertility is concerned and that this is independent of the length of time the couple have been trying and the man's motile sperm density. In two men there was intra-abdominal undescent and both were found to have testis tumours; we would re-emphasise that abdominal exploration is mandatory in such cases.
D000328:Adult; D000367:Age Factors; D000906:Antibodies / Q000032:analysis; D003456:Cryptorchidism / Q000150:complications* / Q000276:immunology / Q000601:surgery; D012739:Gonadal Steroid Hormones / Q000032:analysis; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013094:Spermatozoa / Q000276:immunology; D013736:Testicular Neoplasms / Q000150:complications
D000906:Antibodies; D012739:Gonadal Steroid Hormones