Polygenic control of interferon production induced by poly I:C in vivo. Brief report.
Poly I:C-induced interferon production shows quantitative differences in various mouse strains depending on multiple interactions among genes located both inside and outside the major histocompatibility complex. Moreover, circulating interferon levels do not appear to be under direct genetic control but, rather, to depend on the gene-coded intensity of specific recognition of the inducer.
D000818:Animals; D005796:Genes; D006183:H-2 Antigens / Q000235:genetics; D007372:Interferons / Q000097:blood* / Q000235:genetics; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains / Q000097:blood / Q000235:genetics*; D011070:Poly I-C / Q000494:pharmacology*; D011995:Recombination, Genetic; D013045:Species Specificity
D006183:H-2 Antigens; D007372:Interferons; D011070:Poly I-C