Hepatic effects of R-goitrin in Sprague-Dawley rats.
In male and female rats, R-goitrin treatment increased the relative liver weights; in some of the enlarged livers a high incidence of mitotic figures was observed. R-goitrin treatment increased the relative thyroid weight, more in male rats than in females. The thyroids of R-goitrin treated rats were either hyperplastic or had most follicles filled with pale-staining colloid and rarely follicles with normal, well-stained colloid. At certain doses, R-goitrin increased serum triglycerides, cholesterol, total protein, albumin and calcium, but it decreased serum thyroxine and urea. However, most of these changes in serum chemistry were small. R-goitrin caused a temporary increase in urinary ascorbic acid output in both sexes, but the liver ascorbic acid level was increased only in female rats. The duration of pentobarbital-induced sleep was significantly prolonged by R-goitrin pretreatment only in male rats.
D000818:Animals; D013956:Antithyroid Agents / Q000633:toxicity*; D001205:Ascorbic Acid / Q000652:urine; D001774:Blood Chemical Analysis; D004121:Dimethyl Sulfoxide / Q000633:toxicity; D004326:Drinking / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D008934:Mitogens; D009929:Organ Size / Q000187:drug effects; D010080:Oxazoles / Q000633:toxicity*; D023303:Oxazolidinones; D011409:Propylene Glycols / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects
D013956:Antithyroid Agents; D008934:Mitogens; D010080:Oxazoles; D023303:Oxazolidinones; D011409:Propylene Glycols; C004333:goitrin; D001205:Ascorbic Acid; D004121:Dimethyl Sulfoxide