Selective inhibition by betamethasone of allergen-induced release of SRS-A from human lung.
Passively sensitized human lung, when incubated with the appropriate allergen, released histamine and slow-reacting substance (SRS-A). Betamethasone sodium phosphate (5-100 microgram/ml), preincubated with the lung overnight, suppressed, in a dose-related manner, the release of SRS-A without having an effect on the release of histamine. Preincubation for only 1 h produced little effect on the release of SRS-A or of histamine. These results may help to explain some of the beneficial effects of glucocorticoids in allergic asthma.
D000485:Allergens; D001623:Betamethasone / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006969:Hypersensitivity, Immediate; D007116:Immunization, Passive; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects* / Q000276:immunology; D013189:SRS-A / Q000378:metabolism*
D000485:Allergens; D013189:SRS-A; D001623:Betamethasone