CGS 8216 fails to modify novelty-related behaviour in mice: further evidence for differential actions of benzodiazepine antagonists.
Recent evidence has indicated that, in rats, benzodiazepine antagonists exhibit low-dose intrinsic behavioural properties. In this study, the influence of CGS 8216 (1-20 mg/kg, i.p.) on the responsiveness of male mice to environmental novelty was examined. Unlike Ro 15-1788, which has previously been reported to enhance rearing under the present test conditions, analysis revealed that CGS 8216 was without effect on novelty-related responding. Results are discussed in relation to possible differences in the mode of action of various benzodiazepine antagonists.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000037:antagonists & inhibitors*; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000494:pharmacology; D005442:Flumazenil; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D011720:Pyrazoles; D005442:Flumazenil; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one