Maturation of B-cell clones.
The maturation of B-cells was investigated in adoptive transfers and splenic foci. Anti-idiotypic antigens were used to identify clones responding to PC and dextran. A distinct temporal hierarchy of responsiveness could be observed in which the anti-TNP response appears first, followed by anti-dextran and anti-PC. Tolerance induction and anti-idiotype suppression were used as markers for maturing B-cells responding in splenic foci. A differential susceptibility to these manipulations establishes two types of progenitor cells. A scheme for the maturational steps of B-cells is proposed.
D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D001854:Bone Marrow Cells; D002999:Clone Cells / Q000378:metabolism; D003911:Dextrans / Q000276:immunology; D007108:Immune Tolerance; D008099:Liver / Q000166:cytology; D051379:Mice; D010767:Phosphorylcholine / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology
D003911:Dextrans; D010767:Phosphorylcholine