Effect of Inosiplex on BHK cells "in vitro".
The effect of different Inosiplex doses in tissue culture was studied utilizing a cellular line derived from the Hamster Kidney (BHK). Inosiplex doses used were 0.1, 1, 10 and 100 mg/ml of Eagle basal medium adding 10 per cent of heat inactivated fetal calf serum. Increase in cellular growth that was statistically significant was observed in 10 and 100 microgram/ml Inosiplex doses. Also this substance was studied at same concentrations in other two cellular lines, one derived from loose connective tissue in mice (L-929) and the other from cervical carcinoma (HeLa). In the first, 10 and 100 microgram/ml doses produced growth inhibition while in the second no effect was observed.
D000818:Animals; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D003239:Connective Tissue Cells; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology; D051379:Mice
D007288:Inosine; D007542:Inosine Pranobex