[Effect of polyanions on macrophage-lymphocyte interaction].
The effect of polyanions on the interaction of antigen-stimulated macrophages and lymphocytes was studied in vivo. Treatment of cell mixture of macrophages and lymphocytes with poly = A : U or dextran sulfate induced a considerable increase in the number of lymphocytes contacting with macrophages during the first hours of cultivation. Under similar conditions yeast RNA had a certain anticooperative effect. According to the data obtained by scanning electron microscopy, the contacts between the interacting cells were realized by means of cytoplasmic bridges or close membrane connections.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology*; D008211:Lymphocyte Cooperation / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D008855:Microscopy, Electron, Scanning; D011063:Poly A-U / Q000494:pharmacology*; D012331:RNA, Fungal / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology
D003911:Dextrans; D012331:RNA, Fungal; D011063:Poly A-U; D016264:Dextran Sulfate
Vlliianie polianionov na vzaimodeĭstvie makrofagov i limfotsitov.