[Effect of neurohormone C and hexapeptide on incorporation of labeled amino acids into the proteins of different organs].
The influence of two coronarodilatatory substances (neurohormone "C" and hexapeptide) on the rate of protein synthesis was investigated. The stimulation of incorporation of labelled (14C- and 3H-) leucine into proteins of rat brain, heart and liver tissues characterized the hormonal regulation of the protein synthesis in these organs in vivo. Activation of the protein synthesis depended on the dose of the hormone administered. 5 mg of hexapeptide markedly inhibited the amino acid incorporation into proteins, while 0.5 mg produced the effect, which was contrary to the effect caused by 5 mg of the hormone. The data obtained suggest that hypothalamic neurohormonal preparations exhibit an important effect on protein metabolism in different organs.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007028:Hypothalamic Hormones / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D009842:Oligopeptides / Q000494:pharmacology*; D014176:Protein Biosynthesis; D012313:RNA / Q000032:analysis; D051381:Rats
D007028:Hypothalamic Hormones; D009419:Nerve Tissue Proteins; D009842:Oligopeptides; C022984:cardioactive hexapeptide; D012313:RNA; C022043:neurohormone C; D007930:Leucine
Vliianie neĭrogormona C i geksapeptida na vkliuchenie mechenykh aminokislot v belki razlichnykh organov.