[Behavior of secretin-pancreozymin-stimulated pancreatic secretion, gallbladder contraction and choleresis after somatostatin administration].
The action of somatostatin (250 microgram i. v. + 125 microgram/30 min i. v.) on pancreatic secretion was studied in 8 volunteers and on biliary secretion as measured through a T-tube in 7 volunteers during background stimulation of secretin and pancreozymin (1 U/kg/h). Additional injection of somatostatin was accompanied by a significant (p less than 0,05) decrease in volume and in bicarbonate output for a short time and a significant (p less than 0,05) decrease in trypsin, amylase and lipase output for the studied period. There was no decrease in volume output and bicarbonate concentration as measured in the T-tube. The effect of somatostatin in abolishing the pancreozymin induced contraction of the gallbladder was documented by sonography. The temporary reduction of volume and bicarbonate output in the duodenal lumen could be considered as an inhibitory effect of somatostatin on gallbladder contraction and not as an effect on the exocrine pancreas.
D000328:Adult; D000681:Amylases / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D002766:Cholecystokinin / Q000494:pharmacology; D005704:Gallbladder / Q000187:drug effects*; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology*; D014357:Trypsin / Q000378:metabolism
D001639:Bicarbonates; D012633:Secretin; D013004:Somatostatin; D002766:Cholecystokinin; D008049:Lipase; D000681:Amylases; D014357:Trypsin
Das Verhalten der sekretin-pankreozymin-stimulierten Sekretion des Pankreas, der Gallenblasenkontraktion und der Cholerese unter Somatostatin.