Observation on the capping of spleen lymphocytes from scrapie infected mice after treatment with anti Ig.
Staining of lymphocytes from scrapie-infected STU mice with FITC-labelled anti-mouse Ig revealed disturbances in the capping process when compared with lymphocytes from mock-infected animals. Quantitative evaluation indicates that 10-15% of cells from scrapie-infected animals show an altered capping behaviour. These phenomena are discussed with special reference to the role of the lymphoreticular system in early scrapie agent replication.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D005260:Female; D007152:Immunologic Capping; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D012608:Scrapie / Q000276:immunology*; D012756:Sheep; D013154:Spleen / Q000166:cytology; D013194:Staining and Labeling
D000888:Antibodies, Anti-Idiotypic