title: Effects of short-wave ultraviolet light (UVB) on delayed hypersensitivity in the guinea pig.
abstract: Guinea pigs, previously sensitized to dinitrochlorobenzene (DNCB), were exposed to varying doses of UVB radiation on the right flank for a period of 12 days. The response to an elicitation dose of DNCB was diminished in the irradiated skin immediately after UV treatment. This effect was dose-dependent. No reduction in the response could be demonstrated in unexposed skin. One week after UVB treatment the response to DNCB was increased, and after 2 weeks there was a normal eczematous reaction after application of DNCB.
mesh_terms: D000818:Animals; D004137:Dinitrochlorobenzene; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000517:prevention & control*; D007121:Immunocompetence / Q000528:radiation effects; D012867:Skin / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D004137:Dinitrochlorobenzene