[The measurement of DNA in material obtained by cyto-puncture of the prostate. Diagnostic, prognostic and therapeutic value (author's transl)].
The results of the measurement of deoxyribonucleic acid (DNA) by absorption cytophotometry after Feulgen reaction, in smears of trans-rectal fine needle aspiration of prostate cancers are exposed. The histograms may be distributed in 3 categories: poorly, moderately and highly aneuploïds and heteroplöids. The correlation between the category of ploïdy and the cytological grade is fair but the measurement of DNA offers a diagnostic and prognostic refinement: it distinguishes, among the grade 2 cancers (moderately differenciated) tumours with different potential evolutivity. Repeated measurements in treated patients (with orchiectomy or estrogens) give objective criterias of therapeutical response. Following our experience, the persistence or the reappearance of important abnormalities in the histogram in a treated patient are objective and often premonitory signs of therapeutical escape which invite, even in the absence of clinical evidence of progression, to change the treatment.
D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D010783:Photometry; D011379:Prognosis; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000473:pathology / Q000628:therapy
D004273:DNA, Neoplasm
La mesure de l'ADN dans le produit de cyto-ponction des cancers de la prostate. Intérêt diagnostique, pronostique et thérapeutique.