Expression of recA-gene dependent SOS functions in Salmonella typhimurium.
Thymine starvation of RecA+ Thy- strains of Salmonella typhimurium does not induce the inhibition of cellular respiration, one of the recA-gene dependent SOS functions. Nevertheless, thymine deprivation is able to produce a normal induction of prophage and thymineless death in these same strains However, when these mutants are treated, in the presence of thymine, with UV-irradiation or bleomycin, they show a normal inhibition of cellular respiration and other SOS functions. Thus, one injurious treatment (thymine deprivation) may trigger prophage induction but not cessation of respiration, whereas another agent (UV-irradiation) may induce both. Together, these results suggest a possible discrimination in the pathways and conditions of expression of various SOS functions.
D001761:Bleomycin / Q000494:pharmacology; D003470:Culture Media; D005786:Gene Expression Regulation / Q000187:drug effects / Q000528:radiation effects; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D013941:Thymine; D014466:Ultraviolet Rays / Q000009:adverse effects
D003470:Culture Media; D001761:Bleomycin; D013941:Thymine