Surface immunoglobulin-bearing rabbit lymphocytes express both VH and L chain allotypic determinants.
The cell surface distributions of a locus and b lucus rabbit immunoglobulin allotypes have been examined simultaneously, using immunoelectronmicroscopic techniques. Most rabbit lymphocytes that bear surface immunoglobulin express both a and b markers. This is true of lymphocytes from blood, spleen, and lymph node of normal and immunized rabbits. A preponderance of cells bearing VH markers (a locus) but not L chain markers (b locus) was not observed.
D000818:Animals; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D000939:Epitopes; D006433:Hemocyanins / Q000276:immunology; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D008214:Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D011817:Rabbits; D011947:Receptors, Antigen, B-Cell; D013997:Time Factors
D000939:Epitopes; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D011947:Receptors, Antigen, B-Cell; D006433:Hemocyanins