Inhibitory studies of DNA, RNA and protein synthesis in Escherichia coli by platinum containing complexes.
Previous studies have shown various platinum containing compounds to be effective anti-tumor agents in man and animals. Many of these compounds have also been shown to be effective inhibitors of bacterial DNA, RNA and protein synthesis. Data is presented here which compares the inhibitory effectiveness of a number of recently synthesized platinum compounds toward the inhibition of the synthesis of DNA, RNA and protein in Escherichia coli. We also compared the effectiveness of these compounds toward the inhibition of bacterial growth. Some of these new derivatives appear to be nearly 3-fold more potent than the more thoroughly studied cis-diamminedichloroplatinum(II) (cis-PDD) and trans-diamminedichloroplatinum(II) (trans-PDD).
D001426:Bacterial Proteins / Q000096:biosynthesis*; D002945:Cisplatin / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D012329:RNA, Bacterial / Q000096:biosynthesis*; D013237:Stereoisomerism
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D002945:Cisplatin