Drug-induced antibodies: interaction of the drug with a polymorphic platelet-antigen.
Preincubation of donor platelets with ticarcillin will prevent the reactivity of a platelet antibody against these platelets, whereas no influence was observed on antisera against HLA, 5A, 5b and ZWa. The implications for the mechanism of drug-induced antibodies with restricted specificity will be discussed.
D000917:Antibody Formation / Q000187:drug effects*; D000918:Antibody Specificity / Q000187:drug effects; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D001792:Blood Platelets / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D010406:Penicillins / Q000494:pharmacology*; D013982:Ticarcillin / Q000494:pharmacology*
D000939:Epitopes; D006680:HLA Antigens; D010406:Penicillins; D013982:Ticarcillin