title: Clinical and audiological findings in a case of auditory agnosia.
abstract: A case is reported of severe agnosia for verbal and non-verbal sounds without associated aphasic disorder. A CT scan revealed bilateral, temporal lobe lesions from two ischaemic accidents that had occurred 9 months apart. The search for subtle deficits in the patient showed normal sensitivity to changes in the intensity and frequency of simple sounds; in contrast, his ability to discriminate sound duration and musical note sequences was severely impaired. The simultaneous recording of the whole auditory-evoked response pattern revealed no abnormality in the early components, which reflect the activation of the auditory nuclei and pathways of the brain stem. However, the middle and late components were delayed and slowed. These results and others in the literature suggest that the neocortex in man, as in other mammals, plays an essential role in the temporal aspects of hearing. Also, the two main ingredients commonly recognized in auditory agnosia, i.e. word deafness and the inability to interpret non-verbal sounds, are caused by the disruption of elementary, bilaterally represented cortical functions which start the processing of every kind of auditory information.
mesh_terms: D000377:Agnosia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D001308:Auditory Perceptual Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D002561:Cerebrovascular Disorders / Q000150:complications; D005072:Evoked Potentials, Auditory; D006801:Humans; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D010468:Perceptual Disorders / Q000503:physiopathology*; D013067:Speech Perception / Q000502:physiology; D013702:Temporal Lobe / Q000473:pathology