Interleukin 2 production by both Ly2+ and Ly2- T-cell subsets.
Homogeneous T-cell populations produced by activating lymphocytes to I-, K-, or K+ D- region-encoded determinants of the mouse H-2 complex release interleukin 2 when restimulated by concanavalin A. Contrary to earlier reports on the cellular origin of the lymphokine, we find that interleukin 2 production can be either Ly2+ or Ly2- T-cell-dependent.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D000939:Epitopes; D006183:H-2 Antigens / Q000276:immunology; D006238:Haploidy; D007519:Isoantigens / Q000276:immunology; D008222:Lymphokines / Q000096:biosynthesis*; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D000939:Epitopes; D006183:H-2 Antigens; D007519:Isoantigens; D008222:Lymphokines; D003208:Concanavalin A