Inflammatory potency of antigen-antibody complexes and C-reactive protein in a wound chamber model in rats.
In the present study, the inflammatory potencies of antigens carrying different numbers of determinants, i.e. penicilloyl 5-rat serum albumin and penicilloyl 28-rat serum albumin were compared in a wound chamber model in immunized rats. The results revealed that the antigen with more determinants had a more potent inflammatory effect. The kinetics of the inflammatory responses to the two antigens were similar, however. The inflammation in the chambers was also analyzed against antigen, penicilloyl 26-bovine gamma-globulin and antigen together with the acute phase reactant C-reactive protein of human source (CRP). CRP significantly increased the severity of the inflammation with antigen alone but the kinetics of the responses were similar.
D000818:Animals; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000276:immunology; D002097:C-Reactive Protein / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D007114:Immunization; D066298:In Vitro Techniques; D007249:Inflammation / Q000209:etiology* / Q000276:immunology; D007700:Kinetics; D051381:Rats
D000936:Antigen-Antibody Complex; D000941:Antigens; D000939:Epitopes; D002097:C-Reactive Protein