Immune response to different tick-borne encephalitis vaccines as revealed by lymphocyte blast transformation and virus neutralization tests.
Immunological memory has been demonstrated in lymphocytes of persons vaccinated against tick-borne encephalitis (TBE). Stimulation indices (SI) of lymphocytes in response to TBE virus antigens in lymphocyte blast transformation test increased after complete vaccination course with the commercial vaccine; by this time, sera of vaccinees contained virus neutralizing antibodies. The concentrated purified vaccine had a higher immunogenic activity, as evidenced by increased SI and virus neutralizing antibodies (NA) in the vaccinated subjects already after the first and second vaccinations.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D008297:Male; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D014765:Viral Vaccines