title: In vivo modulation of human lymphocyte Fc gamma-receptors in response to oral antigen (cows' milk) challenge.
abstract: Following consumption of 1.2 litres of cows' milk by normal human adults there was a rapid fall in the proportion of peripheral blood lymphocytes bearing receptors for the reacted Fc of IgG (Fc gamma-receptors). This phenomenon was transient and apparently confined to the lymphocyte Fc gamma-receptor+ve subpopulation. Similar observations were made in rats but only in those animals pre-exposed to cows' milk suggesting that an immunological mechanism is involved. In man it was found that Fc gamma-receptors could only be re-expressed following incubation of post-milk lymphocytes in normal human serum. It is proposed that rapid in vivo modulation of lymphocyte Fc gamma-receptors occurs following oral antigen (cows' milk) challenge probably mediated by soluble food antigen-antibody complexes. The subsequent recovery of these receptors in vivo and in vitro may be due to the binding of 'fluid-phase' Fc gamma-receptors found in normal human serum.
mesh_terms: D000328:Adult; D000818:Animals; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000008:administration & dosage*; D002417:Cattle; D006801:Humans; D007782:Lactoglobulins / Q000276:immunology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008892:Milk / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D012397:Rosette Formation; D012710:Serum Albumin, Bovine / Q000276:immunology; D005719:gamma-Globulins / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D000941:Antigens; D007782:Lactoglobulins; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine