[HLA compatibility and survival of 51 chromium-labeled allogeneic thrombocytes].
In 37 patients with thrombocytopenia (mostly with ITP) the survival time of 51Cr-labeled allogeneic platelets was investigated. The HLA antigens were typed in donors and recipients and the presence of HLA cytotoxins and specific thrombocyte antibodies in sera of patients were examined. In 7 cases the identity of 2 HLA antigens, in 15 cases that of 1 HLA antigen and in 15 cases the HLA incompatibility between donor and patient were found. The survival of platelets did not depend on the degree of HLA compatibility, unless the HLA cytotoxins in sera of patients appeared. The HLA, as well the specific platelet antibodies brought about the shortened platelet survival to 1 day and less. The importance of these observations for platelet kinetics is discussed.
D001792:Blood Platelets / Q000502:physiology*; D001803:Blood Transfusion; D002470:Cell Survival; D002860:Chromium Radioisotopes; D006680:HLA Antigens / Q000032:analysis; D006648:Histocompatibility; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D017713:Platelet Transfusion; D011696:Purpura, Thrombocytopenic / Q000097:blood; D013921:Thrombocytopenia / Q000097:blood
D002860:Chromium Radioisotopes; D006680:HLA Antigens
HLA-Komp]atibilität und Uberlebenszeit von 51Cr-markierten allogenen Thrombozyten.