Cross self-administration of delta 9-tetrahydrocannabinol and D-amphetamine in rats.
1. Schedule-induced intravenous self-injection of delta 9-tetrahydrocannabinol (delta 9-THC) and d-amphetamine was investigated in the same animals. 2. Rats self-injected significantly more amphetamine than delta 9-THC. However, the results suggested that delta 9-THC did not play a predisposing role to the increased amphetamine intake. When delta 9-THC was reinstated after amphetamine response rates were drastically reduced. 3. It is concluded that the reinforcing effects of delta 9-THC may be unrelated to its stimulant effects. The small number of responses for delta 9-THC is in agreement with reports of the poor reinforcing capability of cannabis compounds in rats.
D000818:Animals; D003913:Dextroamphetamine / Q000008:administration & dosage*; D013759:Dronabinol / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar / Q000502:physiology*; D012054:Reinforcement, Psychology; D012646:Self Administration; D019966:Substance-Related Disorders / Q000503:physiopathology*
D013759:Dronabinol; D003913:Dextroamphetamine