Substance P decreases a potassium conductance of spinal cord neurons in cell culture.
Substance P (SP) produced membrane depolarization and decreased membrane conductance of mouse spinal cord neurons in primary dissociated cell culture. SP-responses were abolished by intracellular tetraethylammonium suggesting that SP decreased potassium conductance. Reversal of SP-responses was not observed with membrane hyperpolarization suggesting that SP reduced a voltage-dependent potassium conductance that was activated by membrane depolarization.
D000818:Animals; D002478:Cells, Cultured; D005727:Ganglia, Spinal / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009474:Neurons / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D013116:Spinal Cord / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology
D013373:Substance P; D013779:Tetrodotoxin; D011188:Potassium