Effect of lindane on antibody response to typhoid vaccine in weanling rats.
The immunosuppressive effect of lindane was assessed in weanling rats over a period of 5 weeks. Agglutinin titres against S. typhi 'O' and 'H', S. paratyphi 'AH' and 'BR' antigens were determined following TAB vaccination in control and lindane-fed animals. The titres attained in non-treated controls were higher significantly than those in treated animals indicating a suppressive effect of lindane on humoral immune responses.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D005260:Female; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007166:Immunosuppressive Agents; D008297:Male; D051381:Rats; D014436:Typhoid-Paratyphoid Vaccines / Q000276:immunology
D007166:Immunosuppressive Agents; D014436:Typhoid-Paratyphoid Vaccines; D001556:Hexachlorocyclohexane