Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells.
Oxatomide inhibits the release of histamine from rat peritoneal mast cells in vitro induced by C 48/80, antigen, anti-IgE and ionophore A 23 187, without effect on non-specific release by n-decylamine. Its effect is concentration- and pH-dependent and decreases with increasing extracellular Ca2+-concentrations. Prolonged incubation does not enhance the inhibition, which is lost after one single wash-out. Aminophylline and isoproterenol are not potentiated by oxatomide. The present study points to an effect of oxatomide on a Ca2+-dependent process at the level of cell membrane common to antigen, C 48/80 and ionophore A 23 187.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001202:Ascitic Fluid / Q000166:cytology; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D010879:Piperazines; D007073:Immunoglobulin E; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; C015408:oxatomide; D002118:Calcium