[Prognostic evolution of Graves' disease treated by synthetic antithyroid (author's transl)].
A follow-up of at least 4 years after withdrawal of a medical treatment of 77 patients with Graves' disease is presented. The treatment consisted in Carbimazole (15-30 mg/d), LT3 (75 ug/d), Propranolol (30-60 mg/d), Hydroxyzine (75 mg/d). A normal thyroid suppressibility (20 mm 99m Tc uptake test) is obtained in patients without goiter faster than in those with goiter. A normal early uptake at the sixth month therapy is a good index for cure. Despite this result the authors recommend a treatment of 12 to 18 months duration because of the probable immunodepressive effect of the antithyroid drugs.
D013956:Antithyroid Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002231:Carbimazole / Q000627:therapeutic use; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use; D011379:Prognosis; D011433:Propranolol / Q000627:therapeutic use; D014284:Triiodothyronine / Q000627:therapeutic use
D013956:Antithyroid Agents; D014284:Triiodothyronine; D006919:Hydroxyzine; D002231:Carbimazole; D011433:Propranolol
Pronostic évolutif de la maladie de Basedown traitée par les antithyroïdiens de synthèse.