[Human viral carcinogenesis. RNA-tumor-virus like structures in human leukemia, lymphomas and sarcomas].
As a contribution to the solution of the etiological question of human neoplasias, human leukemias, lymphomas and sarcomas were shown to contain viral structures and/or virus-like particles that resembled analogous animal RNA tumor viruses or their structures. The human particles possess 1. a single stranded, high molecular weight 70s RNA, 2. a RNA-dependent DNA-polymerase, 3. a characteristic density of 1.16--1.19 g/cm3, and 4. a base sequence of their RNA related to the RNA of analogous animal RNA tumor viruses. Although a biological activity of these particles has not been shown, their similarity with analogous animal viruses, their presence in certain neoplasias, and their absence in normal, non-embryonal tissues make some function of these particles in human carcinogenesis likely.
D000818:Animals; D006801:Humans; D007938:Leukemia / Q000382:microbiology*; D008223:Lymphoma / Q000382:microbiology*; D012328:RNA Viruses / Q000302:isolation & purification*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis / Q000378:metabolism; D012190:Retroviridae / Q000302:isolation & purification; D012509:Sarcoma / Q000382:microbiology*; D014412:Tumor Virus Infections / Q000382:microbiology
D012194:RNA-Directed DNA Polymerase
Zur viralen Karzinogenese beim Menschen. RNS-Tumorvirus-ähnliche Strukturen in menschlichen Leukämien, Lymphomen und Sarkomen.