[Mg2+-ATPase activity of brain mitochondria fractions in chronic stress and its correction by psychotropic agents].
The activity of Mg2+-ATPase was determined in the cortex mitochondrial fraction, limbic system and medulla oblongata under conditions of chronic stress as well as against a background of preliminary therapy by psychotropic drugs. At the inanition stage of animals the chronic stress is shown to inhibit sharply the process of respiration and phosphorylation (by dissociation) and to decrease the content of brain macroergs. The activity of Mg2+-ATPase in the mitochondrial fractions is lowered. It practically restores to the control level against a background of stress with preliminary course of administering nicotinic acid and GABA derivatives (lithonite, nicogamol and phenibut) to rats in average therapeutic doses. Mebicar, meprobamate and chlorodiazepoxide produce a less pronounced normalizing effect on the activity under study. It is substantiated to be expedient to apply psychotropic drugs as stress-protectors for normalization of energy metabolism of brain neurons.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use; D001569:Benzodiazepines; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D017301:Ca(2+) Mg(2+)-ATPase; D002908:Chronic Disease; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000201:enzymology* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000188:drug therapy / Q000201:enzymology*
D014151:Anti-Anxiety Agents; D011619:Psychotropic Drugs; D001569:Benzodiazepines; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase
Aktivnost' Mg2+-ATPazy fraktsii mitokhondriĭ mozga pri khronicheskom stresse i ego korrektsii psikhotropnymi sredstvami.