Response of rat exocrine pancreas to chronic pulmonary ethanol intoxication.
Rats were intoxicated over a 32-day period by continuous exposure to an ethanol-enriched atmosphere. Under these conditions, body weights increased up to day 26 and blood ethanol levels increased to approximately 2 g/liter. Pancreatic and hepatic histologies were normal. Amylase levels and total pancreatic protein decreased, while lipase levels rose. These changes appear to be independent of the caloric balance of the diet.
D000435:Alcoholic Intoxication / Q000378:metabolism* / Q000473:pathology; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002919:Chymotrypsinogen / Q000378:metabolism; D004032:Diet; D000431:Ethanol / Q000097:blood; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000201:enzymology* / Q000473:pathology; D051381:Rats; D014362:Trypsinogen / Q000378:metabolism
D000431:Ethanol; D014362:Trypsinogen; D002919:Chymotrypsinogen; D008049:Lipase; D000681:Amylases