A synthetic ionophore for Ca2+: studies with model and biological systems.
We show that the relatively simple beta-diketone, 1.1.1.2.2.3.3-heptafluoro-7,7-dimethyloctane-4,6-dione, known as "fod", will solvate Ca2+ ions in an organic phase. In consequence it will transport Ca2+ across phospholipid bilayers. It acts as predicted for a Ca2+-transporting ionophore in two biological systems: it will stimulate Ca2+-dependent K+ efflux from human red blood cells, and Ca2+-dependent histamine secretion from rat peritoneal mast cells.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002784:Cholesterol; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology*; D007476:Ionophores / Q000494:pharmacology*; D008081:Liposomes; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D010713:Phosphatidylcholines; D011188:Potassium / Q000097:blood; D051381:Rats; D005466:Fluorocarbons
D002118:Calcium; D002784:Cholesterol; D006845:Hydrocarbons, Fluorinated; D007476:Ionophores; D008081:Liposomes; D010713:Phosphatidylcholines; D011188:Potassium; C029279:6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedione; D005466:Fluorocarbons