[Goitrogens of vegetable origin as possible aetiological factors in endemic goiter (author's transl)].
Ingestion of unsoaked cassava is followed by an increase of the thiocyanate production in men and in rats. Even a moderate increase of serum SCN concentration induces, in chronic conditions, a clearcut goitrogenic effect characterized by the aggravation of the effects of a preexisting iodine deficiency. The mechanism of the antithyroid action of SCN at low concentrations, lies in an acceleration of the exit rate of thyroidal iodide; this effect cannot be identified by the usual clinical investigation with Iodine131.
D000818:Animals; D013956:Antithyroid Agents; D006043:Goiter, Endemic / Q000139:chemically induced*; D006801:Humans; D051381:Rats; D013861:Thiocyanates / Q000009:adverse effects* / Q000097:blood; D014675:Vegetables
D013956:Antithyroid Agents; D013861:Thiocyanates
Intervention de goitrigènes d'origine végétale dans l'étiologie du goitre endémique.