Albumin and beta 2-microglobulin excretion in patients on long-term lithium treatment.
Albumin and beta 2-microglobulin excretions were studied in 85 unselected patients treated with lithium for more than 6 months. In 15 patients a lithium-induced impaired renal concentrating ability was found, 13 of these patients revealed a chronic interstitial nephropathy on renal biopsy. There was no significant increase in albumin excretion, and a markedly increased beta 2-microglobulin excretion was seen in only 1 patient. This study supports the hypothesis that the lithium-induced renal lesion in confirmed to the distal part of the nephron.
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000139:chemically induced*; D001609:Beta-Globulins / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects; D008094:Lithium / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D009399:Nephrons / Q000187:drug effects; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000652:urine*
D001609:Beta-Globulins; D001613:beta 2-Microglobulin; D008094:Lithium