Calcium causes the biphasic dose-response curve for pancreatic amylase secretion.
High concentrations of bethanechol (10(-4) to 10(-3) M) were effective stimulants of amylase secretion from the mouse pancreas if incubations are performed in low [Ca2+] (0.1 mM) solutions but not if normal Krebs solution (2.56 mM Ca2+) was used. This inhibitory effect of Ca2+ at high secretagogue concentrations did not appear to be mediated through the microtubules or microfilaments.
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D003571:Cytochalasin B / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*
D001626:Bethanechol Compounds; D003571:Cytochalasin B; D000681:Amylases; D002118:Calcium