Mechanism of interferon action. Interferon-mediated inhibition of reovirus mRNA translation in the absence of detectable mRNA degradation but in the presence of protein phosphorylation.
D000818:Animals; D002474:Cell-Free System; D007372:Interferons / Q000494:pharmacology*; D007700:Kinetics; D007739:L Cells / Q000187:drug effects; D012089:Mammalian orthoreovirus 3 / Q000187:drug effects*; D051379:Mice; D008836:Micrococcal Nuclease / Q000494:pharmacology; D010448:Peptide Initiation Factors / Q000378:metabolism; D010766:Phosphorylation; D014176:Protein Biosynthesis / Q000187:drug effects*; D012330:RNA, Double-Stranded / Q000378:metabolism / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000494:pharmacology; D012367:RNA, Viral / Q000378:metabolism; D012087:Reoviridae / Q000187:drug effects*; D012269:Ribosomal Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D010448:Peptide Initiation Factors; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D012367:RNA, Viral; D012269:Ribosomal Proteins; D014764:Viral Proteins; D007372:Interferons; D012343:RNA, Transfer; D008836:Micrococcal Nuclease