title: [Whipple disease of the CNS].
abstract: By the example of two cases that could only be cleared up by a postmortem examination the affection of the central nervous system by Whipple's disease is dealt with. The granulomatous inflammatory process which is almost exclusively localised in the grisea and shows a particular concentration in the diencephalon, in the cortex of the frontal, temporal and islet regions as well as in the deeper brain stem, had resulted in a variety of neurological-psychiatric symptoms, in most cases a systemic psychosyndrome, myoclonism and paresis of ocular movement. In both cases the diagnoses was verified by the electromicroscopic identification of the bacteria in the typical SPC cells.
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology*; D004660:Encephalitis / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D019965:Neurocognitive Disorders / Q000473:pathology; D008061:Whipple Disease / Q000473:pathology*
vernacular_title: Morbus Whipple des ZNS.