Effect of ganglionic blockade with trimethaphan on corticosteroid responses to metoclopramide in rhesus monkeys.
In order to investigate whether metoclopramide stimulates 18-hydroxycorticosterone and aldosterone production directly by way of the autonomic nervous system, we have examined the effects of ganglionic blockade with trimethaphan on the responses to metoclopramide (200 micrograms/kg) in rhesus monkeys. Trimethaphan, infused at a rate (200 micrograms/kg/min) which significantly decreased mean arterial pressure from 122 +/- 7 to 62 +/- 4 mmHg, did not alter the peak plasma 18-OHB and aldosterone responses to metoclopramide. These results suggest that 18-hydroxycorticosterone and aldosterone responses to metoclopramide occur independently of adrenergic neuronal input.
D015069:18-Hydroxycorticosterone / Q000378:metabolism*; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003345:Corticosterone / Q000031:analogs & derivatives*; D005730:Ganglionic Blockers; D006854:Hydrocortisone / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D012083:Renin / Q000097:blood; D014294:Trimethaphan / Q000494:pharmacology*
D005730:Ganglionic Blockers; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D014294:Trimethaphan; D011388:Prolactin; D012083:Renin; D008787:Metoclopramide; D003345:Corticosterone; D006854:Hydrocortisone