[Effect of various xenobiotics on the in vivo incorporation of 14C-acetate into cholesterol and other lipids in the rat].
Effects of some xenobiotics on the incorporation in vivo of [14C]-acetate into cholesterol and other lipids of the rat DDT, HCH, polychlorinated biphenyl, chlorcholine chloride, ethylenthiourea and mixtures of these substances were given to rats with the feed for 7 days. After that the incorporation of [14C]-acetate into phospholipids, triglycerides and cholesterol was studied in liver, serum, heart and brain. The influence of the xenobiotics on the synthesis, transport and accumulation differed among the various organs and lipids. Outstanding was an increase of 14C-phospholipids, -triglycerides and -cholesterol in the heart after administration of polychlorinated biphenyl. The effects in the peripheral organs were generally more distinct than on the liver.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D002250:Carbon Radioisotopes; D002716:Chlormequat / Q000494:pharmacology; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D003634:DDT / Q000494:pharmacology; D004338:Drug Combinations; D005031:Ethylenethiourea / Q000494:pharmacology; D001556:Hexachlorocyclohexane / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis* / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D002250:Carbon Radioisotopes; D004338:Drug Combinations; D008055:Lipids; D005031:Ethylenethiourea; D001556:Hexachlorocyclohexane; C025647:clophen A50; D002716:Chlormequat; D002784:Cholesterol; D003634:DDT; D011078:Polychlorinated Biphenyls
Die Wirkung einiger Fremdstoffe auf den in vivo-Einbau von [14C]-Azetat in Cholesterol und andere Lipide der Ratte.