Comparative anxiolytic and hypnotic effects of 3 benzodiazepines on baboons.
The ECoG and behavioural effects of administering 3 benzodiazepines (diazepam, nitrazepam, lorazepam) were tested in baboons restrained in a chair, with arms fastened (a situation which is considered 'anxiogenic'). Considering our previous data with ECoG recording of focal rhythms from area somatic I, the 3 drugs were revealed as 'anxiolytic'. Differences were noticed with respect to their hypnotic effects: no sleep was elicited under diazepam; a considerable amount of slow sleep was observed with lorazepam; nitrazepam produced a succession of short waking/sleep cycles.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D001143:Arousal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008140:Lorazepam / Q000494:pharmacology; D009567:Nitrazepam / Q000494:pharmacology; D010215:Papio
D014151:Anti-Anxiety Agents; D009567:Nitrazepam; D008140:Lorazepam; D003975:Diazepam