The immediate haemodynamic effects of MPV 295 (4(5)-2-(2,6-dimethylphenyl)ethylimidazole), a new vasoactive agent with alpha-adrenoceptor agonistic properties, in the anaesthetized dog.
We have evaluated the immediate (0-30 min) circulatory effects of an i.v. bolus of a new compound, MPV 295, an imidazole derivative (1 to 120 micrograms/kg of b.w.) on anaesthetized (morphine, pentobarbital), normotensive, artificially ventilated beagle dogs using catheterization technique. MPV 295 firstly raised and then decreased aortic pressures at dose 30 micrograms/kg. Systolic pressure decreased also at doses 15 and 60 micrograms/kg. Heart rate and cardiac output decreased but the change in cardiac output was significant only at dose 30 micrograms/kg. Peripheral vascular resistance increased. Pulmonary arterial systolic pressure decreased at dose 15 micrograms/kg but did not respond significantly to other doses. In conclusion, MPV 295 exerted an initial sympathomimetic action which was followed by hypotensive effect with the former being peripheral and the latter central in origin. It showed a narrow dosage range for the hypotensive action and, like clonidine, appeared to be an alpha 2-agonist in qualification experiments.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D011652:Pulmonary Circulation / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; C038226:4(5)-2-(2,6-dimethylphenyl)ethylimidazole