Studies on the influence of combustion exhaust gases and the products of their reaction with ammonia on the living organism. I. The influence on DNA, RNA and soluble proteins in the liver of guinea pig.
The paper presents the behaviour of DNA, RNA and soluble proteins in whole homogenate as well as the nuclear, mitochondrial and postmitochondrial liver fractions in guinea pigs exposed to combustion exhaust gases and the products of their reaction with ammonia. A decrease of RNA level was found in the liver of animals exposed to combustion exhaust gases together with a decrease of soluble proteins in all the studied fractions. On the other hand, in the group of animals subjected to the action of neutralization products of combustion gases by ammonia, the studied components were increased. This increase may be the result of the simultaneous action of industrial noise.
D000641:Ammonia / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D001335:Vehicle Emissions / Q000633:toxicity*
D001335:Vehicle Emissions; D012313:RNA; D000641:Ammonia; D004247:DNA