Association of a Sindbis-like virus with Ockelbo disease in Sweden.
An alphavirus isolated from Culiseta mosquitoes has been associated with Ockelbo disease, an exanthema arthralgia syndrome occurring in Sweden. The isolate was made from mosquitoes collected in Edsbyn (central Sweden), an area with considerable Ockelbo disease morbidity. This isolate proved to be indistinguishable from Sindbis virus by complement-fixation and hemagglutination-inhibition tests, and was antigenically related to Sindbis in plaque reduction neutralization tests. Patients with Ockelbo disease developed neutralizing antibodies to the virus in their convalescent sera, suggesting that it is the etiologic agent of the disease.
D000330:Aedes / Q000382:microbiology; D000524:Alphavirus / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D003168:Complement Fixation Tests; D009033:Culicidae / Q000382:microbiology; D004683:Encephalomyelitis, Equine / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007303:Insect Vectors / Q000382:microbiology; D009500:Neutralization Tests; D012843:Simuliidae / Q000382:microbiology; D012845:Sindbis Virus / Q000276:immunology / Q000302:isolation & purification*; D013548:Sweden; D014036:Togaviridae Infections / Q000382:microbiology* / Q000635:transmission
D000914:Antibodies, Viral