Effects of nitroheterocyclic sensitizers on erythrocyte membranes ATP-ase activity.
The effect of two nitroimidazoles, 1(2'-hydroxy-3'-chloropropyl)-2-methyl-4-nitroimidazol and 1(2'-hydroxy-3'-chloropropyl)-2-methyl-5-nitroimidazol and irradiation on erythrocyte membrane ATP-ase activity was studied. The action of nitroimidazole derivatives on the erythrocyte membrane ATP-ase activity differed depending on the nitro group position. 5-Nitroimidazole derivative in the concentration of 300 micrograms/mg protein inhibited significantly the non-irradiated erythrocyte membrane (Na+, K+) ATP-ase activity, while 4-NO2 in the concentration of 3 micrograms/mg protein influenced this activity, but only after an exposure at dose of 60 Krad. In the concentration of 300 micrograms/mg membrane protein it activated this ATP-ase.
D000251:Adenosine Triphosphatases / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism; D017301:Ca(2+) Mg(2+)-ATPase; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D009593:Nitroimidazoles / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D001798:Blood Proteins; D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase