[The effect of exclusion of thyroid hormones on cardiac adaptation to increased work load in rabbits].
The authors studied, in experiments in rabbits (26), the effect of exclusion of thyroid hormones on the formation and evolution of cardiac hypertrophy in animals with artificial insufficiency of the aortic valves. Lack of thyroid hormones due to thyroidectomy, according to the observation of the authors, led to slowing down of the growth of the mass of the heart muscle and to increased concentrations of ribonucleic acid, i. e. to changes usually observed during increased work loads of the heart. Thyroidectomy also prevented the occurrence of certain changes in the concentration of proteins in the subcellular structures of the heart muscle, which usually accompany the formation and evolution of hypertrophy. The authors present the hypothesis that the hormones of the thyroid gland play an important role in adaptation of the heart to increased work loads, but they are not indispensable for the onset and evolution of cardiac hypertrophy.
D000222:Adaptation, Physiological; D000818:Animals; D001022:Aortic Valve Insufficiency / Q000503:physiopathology*; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology*; D004247:DNA / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009929:Organ Size; D012313:RNA / Q000378:metabolism; D011817:Rabbits; D013963:Thyroid Hormones / Q000502:physiology*
D013963:Thyroid Hormones; D012313:RNA; D004247:DNA
Vplyv vyradenia tyreoidálnych hormónov v procese adaptácie srdca na zvýsené pracovné zatazenie u králikov.