A comparison of demyelinating and myelination-inhibiting factor induction by whole peripheral nerve tissue and P2 protein.
Sera from rabbits sensitized with whole bovine spinal roots demyelinated and inhibited myelination in both peripheral and central nervous system tissue cultures. Antisera directed against the peripheral nerve myelin basic protein, P2, demonstrated no antimyelin activity in vitro. These results suggest that demyelinating and myelination-inhibiting factors are directed against some peripheral nerve component(s) other than the P2 protein.
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D007106:Immune Sera; D007118:Immunoassay; D051379:Mice; D004676:Myelin Basic Protein / Q000494:pharmacology*; D018996:Myelin P2 Protein; D009186:Myelin Sheath / Q000187:drug effects / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology
D007106:Immune Sera; D004676:Myelin Basic Protein; D018996:Myelin P2 Protein