Dextran sulphate induced arthritis in rabbits.
Persistent effects of a short course of intra-articular dextran sulphate, dextrans, or chondroitin sulphate were examined in rabbit knees. Only dextran sulphate produced gross arthritis, associated with high synovial acid phosphatase and beta-glucuronidase activities. Synovial degradative capacity in synovium-cartilage cocultures was increased 2-fold by dextran sulphate and 1.5-fold by chondroitin sulphate treatments. Stimulation of cartilage breakdown in vitro paralleled the content of synovial marker enzyme at death of the animal, but the 2 responses could be dissociated.
D000818:Animals; D001168:Arthritis / Q000139:chemically induced* / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism; D002807:Chondroitin / Q000031:analogs & derivatives; D002809:Chondroitin Sulfates; D046508:Culture Techniques; D003911:Dextrans; D007719:Knee Joint; D011509:Proteoglycans / Q000378:metabolism; D011817:Rabbits; D013431:Sulfates; D013583:Synovial Membrane / Q000201:enzymology
D003911:Dextrans; D011509:Proteoglycans; D013431:Sulfates; D002807:Chondroitin; D002809:Chondroitin Sulfates