title: Distribution of antigenicity in chicken erythrocyte histone H5.
abstract: We have compared the inhibitory strengths of eight peptides from chicken histone H5 to that of the parent protein (189 residues) in complement fixation by guinea pig anti-H5 serum complexed with the homologous histone. Two precisely delineated regions (residues 59 to 65 and 94 to 99) and two less-defined regions (between 66 and 93; 100 and 189) are depicted. The sequences of particular consequences are quite conserved in avian histone H5 while the most variable N-terminal portion of 31 residues has no inhibitory effect.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens / Q000097:blood*; D003168:Complement Fixation Tests; D000939:Epitopes / Q000032:analysis*; D004912:Erythrocytes / Q000032:analysis*; D006168:Guinea Pigs; D006657:Histones / Q000097:blood / Q000276:immunology*; D007158:Immunologic Techniques; D010446:Peptide Fragments / Q000276:immunology
chemical_list: D000939:Epitopes; D006657:Histones; D010446:Peptide Fragments