[Antibodies against interspecies erythrokaryocyte antigen in patients with partial red cell aplasia of the bone marrow].
Immunofluorescense and cytotoxicity test in vitro were used to demonstrate specific antibodies in sera of 11 out of 19 patients with partial red cell aplasia (PRCA). The antibodies reacted with erythroblast cells from embryos and adult men, with bone marrow cells from a female patient suffering from acute erythroleukemia, with erythrokaryocytes of mouse embryos and cells of Rauscher's viral erythroleukemia. The results of cross adsorption and blockade of the immunofluorescent reaction of the sera of PRCA patients with antibodies against mouse erythroblast antigen bearing an interspecies determinant suggest that in the pathogenesis of PRCA there takes part an autoimmune reaction against specific interspecies antigen to erythrokaryocytes. This antigen is apparently similar to antigen against mouse erythroblast cells.
D000741:Anemia, Aplastic / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007942:Leukemia, Experimental / Q000276:immunology; D008099:Liver / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C; D011925:Rauscher Virus; D013045:Species Specificity
D001323:Autoantibodies; D000939:Epitopes
Antitela protiv mezhvidovogo antigena éritrokariotsitov u bol'nykh partsial'noĭ krasnokletochnoĭ aplazieĭ kostnogo mozga.