Diverse mechanisms in the generation of human beta-tubulin pseudogenes.
The sequence of two human beta-tubulin pseudogenes is described. One contains an intervening sequence but lacks sequences encoding the 55 N-terminal amino acids of the polypeptide chain. A second has no introns but has a polyadenylate signal and an oligoadenylate tract at its 3' end, and it is flanked by a short direct repeat. These sequences have arisen by different mechanisms, including one that probably involves reverse transcription of a processed messenger RNA and reintegration of the complementary DNA copy into the genome.
D001483:Base Sequence; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D004251:DNA Transposable Elements; D004274:DNA, Recombinant; D005786:Gene Expression Regulation; D006801:Humans; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000235:genetics; D012326:RNA Splicing; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D011995:Recombination, Genetic; D014404:Tubulin / Q000235:genetics*
D004251:DNA Transposable Elements; D004274:DNA, Recombinant; D014404:Tubulin; D011061:Poly A; D004247:DNA; D012194:RNA-Directed DNA Polymerase; D004262:DNA Restriction Enzymes