Substance P: does it produce analgesia or hyperalgesia?
In the hot plate test, substance P given intravenously at doses of 5 x 10-5 and 5 x 10-4 gram per kilogram caused analgesia, while lower doses caused hyperalgesia. The influence of substance P on nociception depended on the individual mouse's sensitivity to pain (control response latency). Analgesia was produced by substance P administered to mice with high sensitivity to thermic stimulation, whereas hyperalgesia occurred in mice whose control latencies were longer than normal. This result is interpreted as an indication that substance P is capable of normalizing responsiveness to pain and could be classified as a regulatory peptide.
D000085:Acetates; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced*; D006941:Hyperesthesia / Q000139:chemically induced*; D051379:Mice; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000503:physiopathology*; D010465:Perception / Q000187:drug effects*; D011955:Receptors, Drug / Q000502:physiology; D013373:Substance P / Q000494:pharmacology*
D000085:Acetates; D011955:Receptors, Drug; D013373:Substance P