Leukocyte migration inhibition with Epstein-Barr virus negative and positive cell extracts.
Leukocyte migration inhibition of seronegative and seropositive healthy children and that of patients with infectious mononucleosis was studied in the presence of EBV-negative and -positive cell extracts. Seronegative children showed no alteration of the leukocyte migration in the presence of the extracts. EBV-positive cell extracts caused significant migration inhibition in the group of seropositive healthy children and of IM patients. The effect was specific, since the EBV-negative cell extract had no inhibitory effect. In the acute phase of infectious mononucleosis a depressed response was observed, while after recovery the same migration inhibition could be detected. The possible cause of the depressed cell-mediated immune response in the acute phase of the disease is discussed.
D000293:Adolescent; D000956:Antigens, Viral; D002460:Cell Line; D002464:Cell Migration Inhibition; D002648:Child; D002675:Child, Preschool; D000939:Epitopes; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007244:Infectious Mononucleosis / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008297:Male
D000956:Antigens, Viral; D000939:Epitopes; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M