Chemical characterization of substance P-like immunoreactivity in primary afferent neurones.
Substance P-like immunoreactivity (SPLI) in rat dorsal root ganglia and dorsal spinal cord was characterized by high-performance liquid chromatography followed by radioimmunoassay. In spinal cord and ganglia, respectively, 87% and 64% of SPLI eluted with authentic SP. The remainder of the SPLI in ganglia eluted as a single peak which did not represent the sulphoxide of SP or any of its C-terminal fragments.
D000344:Afferent Pathways / Q000032:analysis*; D000818:Animals; D005727:Ganglia, Spinal / Q000032:analysis; D009474:Neurons / Q000032:analysis*; D009928:Organ Specificity; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000032:analysis; D013373:Substance P / Q000032:analysis*
D013373:Substance P