Influence of dimercaprol (2,3-dimercapto-1-propanol) on the pharmacokinetics of 111In-bleomycin in the P-1798 lymphoma-bearing BALB/c mouse.
The pharmacokinetics of 111 indium-labeled bleomycin were altered in the P-1798 tumor-bearing BALB/c mouse when pretreated with the dithiol 2,3-dimercapto-1-propanol (Bal). 1 mg of BAL administered 1 h prior to 20 microCi of 111In-bleomycin resulted in 2:1 tumor loading and 3:1 liver loading of 111In-bleomycin over controls (p less than or equal to 0.05 at the 2- to 3-hour interval). Muscle uptake during this interval remained at unity.
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000378:metabolism*; D004112:Dimercaprol / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D007204:Indium; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008223:Lymphoma / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009132:Muscles / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011868:Radioisotopes
D011868:Radioisotopes; D007204:Indium; D004112:Dimercaprol; D001761:Bleomycin