Acrylamide and 2,5-hexanedione neuropathies: abnormal bidirectional transport rate in distal axons.
Events taking place in the distal axon including delivery, turn-around and return of labelled materials toward the cell body were examined in 2,5-hexanedione (2,5-HD) and acrylamide-induced neuropathies. Retrograde transport profiles obtained from 2,5-HD as well as acrylamide intoxicated axons demonstrated a delay in the time of onset of accumulation and a decrease in the amount of returning activity to the distal collection segment. Integral analysis of the data indicated a decrease in bidirectional transport rate within the distal axons rather than a failure in the turn-around process at the nerve terminal.
D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D006588:Hexanones / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*
D000178:Acrylamides; D006588:Hexanones; D007659:Ketones; C011269:2,5-hexanedione