title: Bleomycin-mediated DNA cross-links are dependent on closed-circular molecules with superhelical turns.
abstract: Non-covalent intermolecular DNA cross-links are created by reaction with the antitumor antibiotic, bleomycin. The cross-links are observed only when the reactant covalently closed circular duplex DNA contains either positive or negative superhelical turns. Multiple sites of cross-linking often extend over 500 base-pairs or more in length.
mesh_terms: D001435:Bacteriophages; D001761:Bleomycin / Q000494:pharmacology*; D003432:Cross-Linking Reagents; D004270:DNA, Circular / Q000378:metabolism*; D004278:DNA, Superhelical / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism
chemical_list: D003432:Cross-Linking Reagents; D004270:DNA, Circular; D004278:DNA, Superhelical; D004279:DNA, Viral; D001761:Bleomycin