Species and tissue differences of histamine storage and release.
Histamine release by compound 48/80 was studied in vivo and in vitro in different tissues of the cat and rat. A good correlation was fond between both kinds of experiment. The histamine stores in the cat salivary gland are poorly sensitive to this histamine-liberating substance. In vitro studies with heart and lungs of the rat and guinea pig showed no correlation between the spontaneous histamine release and the release induced by compound 48/80. This finding suggests the existence of two pools of tissue histamine, both with different storage and release properties, and most probably with different functions in the body.
D000818:Animals; D002415:Cats; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D006636:Histamine Release; D008168:Lung / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism; D013045:Species Specificity; D013363:Submandibular Gland / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine