title: Sickle cell traits in Canada. Trimodal distribution of Hb S as a result of interaction with alpha-thalassaemia gene.
abstract: A trimodal distribution of the amounts of Hb S in 56 sickle cell heterozygotes was observed. The variable amounts of Hb S were directly related to the mean cell volume and the mean cell Hb and were a result of the difference in net synthesis of Hb S due to the presence of the alpha-thalassaemia. Double heterozygotes for the Hb S and alpha-thalassaemia-1 genes, besides having a lower amount of Hb S in the red blood cells, were found to have lower Hb and slightly elevated Hb A2 levels.
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000235:genetics*; D002170:Canada; D002648:Child; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006441:Hemoglobin A / Q000032:analysis / Q000235:genetics*; D006443:Hemoglobin A2 / Q000032:analysis / Q000235:genetics*; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006579:Heterozygote; D006801:Humans; D008297:Male; D012805:Sickle Cell Trait / Q000097:blood / Q000235:genetics*; D013789:Thalassemia / Q000097:blood / Q000235:genetics*
chemical_list: D006451:Hemoglobin, Sickle; D006441:Hemoglobin A; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin