title: SF-1771, a new antibiotic related to bleomycin.
abstract: A new antibiotic, substance SF-1771, has been isolated for the fermentation broth of Streptomyces toyocaensis SF-1771. The antibiotic is highly active against Gram-positive and -negative bacteria and effective against sarcoma 180 cells of ascites type in mice. It belonged to the phleomycin-bleomycin group antibiotics, but has been differentiated from the known antibiotics by the physiochemical properties, chromatographic behaviors and amino acid analysis.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001761:Bleomycin / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media; D004352:Drug Resistance, Microbial; D051379:Mice; D012510:Sarcoma 180 / Q000473:pathology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D003470:Culture Media; C030871:SF-1771 substance; D001761:Bleomycin