[Effect of organophosphate and organochlorine pesticides on the physical work capacity of rats under a varying temperature regimen].
The effect of chlorophos (CP), diazinone (DZ) and lindane (Ln) on the physical endurance of rats was assayed by compelling the animals to swim just short of drowning. Once having received pesticide treatment, part of the animals were placed under conditions of high or low temperature. It was found that a change of 4 degrees C in the heat regimen of intact rats led to increase in their working capacity. CP, Dz and Ln lowered the working capacity. This effect was most pronounced, when animals were previously placed in environment of high temperature, milder, but still significant--when placed at low temperature, and insignificant--at room temperature. Even low pesticide doses, ordinarily producing no clinical symptoms of poisoning, exerted this effect. The pesticides included in this study decreased the working capacity of rats, when the animals were placed at temperature extremes by interfering with the ability of animals for adjustment and by inhibiting the normal stimulation of their working capacity in response to low environmental temperature.
D000818:Animals; D003976:Diazinon / Q000494:pharmacology*; D005260:Female; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D010807:Physical Endurance / Q000187:drug effects*; D051381:Rats; D013550:Swimming; D013696:Temperature; D013997:Time Factors; D014236:Trichlorfon / Q000494:pharmacology*
D007306:Insecticides; D001556:Hexachlorocyclohexane; D014236:Trichlorfon; D003976:Diazinon
Vliianie na fosfor- i khlororganichni pestitsidi vurkhu fizicheskata rabotosposobnost na plukhove pri razlichen temperaturen rezhim.