title: The role of cell surface proteins in the induction of histogenetic differentiative responses by some human breast tumours and hamster tumors implanted into chick embryos.
abstract: Cells of human breast tumours and fibrocystic hyperplasia grown in culture, and three hamster tumours were implanted between the cell layers of 18-hour-old chick blastoderm. Their ability to induce histogenetic responses in the ectodermal and endodermal embryonic tissues was investigated. The surface proteins of these tumour cells were labelled by lactoperoxidase-catalysed radioiodination. It is shown that the ability to induce the histogenetic effects may be related to the expression of 265K (K = 10(3) daltons) and 233K proteins on the surface of human tumour cells and of 115K proteins on the hamster tumour cells. The antiproteinase, aprotinin, inhibits the induction of the histogenetic responses by and apparently also prevents the deletion of 115K proteins from the hamster tumour cells. It is therefore suggested that cell surface proteins are involved in the complex processes of interaction between embryonic and tumour cells and in the recognition by the embryonic cells of the tumour cells implanted into their midst.
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001943:Breast Neoplasms / Q000648:ultrastructure*; D002454:Cell Differentiation / Q000187:drug effects; D002642:Chick Embryo; D006224:Cricetinae; D005354:Fibrosarcoma / Q000648:ultrastructure; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000648:ultrastructure; D008565:Membrane Proteins / Q000502:physiology*; D012513:Sarcoma, Experimental / Q000648:ultrastructure*
chemical_list: D008565:Membrane Proteins; D007611:Aprotinin