Nature of the antigenic determinants of T locus antigens.
The nature of the antigenic specificities of several antigens associated with the T/t complex in the mouse were analyzed by means of glycosidase and haptene inhibition studies. Results indicate that on testicular cells sugar residues are involved in at least six different T/t antigenic determinants. The immunodominant sugar appears to be different for each of the specificities. The specificity for the following T/t antigens resides predominantly in the sugars indicated: T:sialic acid; t12:beta-D-galactose; tw32:beta-D-galactose; t0:L-fucose; tw1:N-acetyl-D-galactosamine; tw18:L-fucose. It seems probable that these sugars are found at the terminal reducing ends of the carbohydrate portion of T/t-bearing moleculse. These studies imply that at least some of the genes in the T locus code for glycosyltransferases or regulators of glycosyltransferases which modigy oligosaccharide structures and impart specificity to the T/t antigens by alteration of their terminal sugar residues.
D000116:Acetylgalactosamine / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000235:genetics / Q000276:immunology*; D002241:Carbohydrates / Q000276:immunology*; D000939:Epitopes; D005643:Fucose / Q000276:immunology; D005690:Galactose / Q000276:immunology; D005796:Genes; D008297:Male; D051379:Mice; D009439:Neuraminidase / Q000494:pharmacology; D013737:Testis / Q000166:cytology / Q000276:immunology*
D000941:Antigens; D002241:Carbohydrates; D000939:Epitopes; D005643:Fucose; D009439:Neuraminidase; D000116:Acetylgalactosamine; D005690:Galactose