title: Recombinant human leukocyte interferon produced in bacteria has antiproliferative activity.
abstract: Recombinant human leukocyte interferon synthesized by Escherichia coli possesses antiproliferative activity in addition to antiviral activity. When the ability to inhibit multiplication of lymphoblastoid Daudi cells was examined, the growth-inhibitory capacity of recombinant leukocyte interferon was equivalent to that exhibited by crude human leukocyte interferon or by the homogeneous gamma 2 species of leukocyte interferon synthesized by human cells.
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004274:DNA, Recombinant / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D007962:Leukocytes / Q000378:metabolism*; D008214:Lymphocytes
chemical_list: D004274:DNA, Recombinant; D007372:Interferons