title: Vasodilatation augments the blood-brain barrier lesions induced by an acute rise in intracarotid pressure.
abstract: The vessel wall tension is the product of pressure and internal radius divided by the vessel wall thickness. Hence, dilated vessels will be exposed to higher tension at a given intraluminal pressure. Provided the rise in cerebrovascular intraluminal pressure is sufficiently prominent, transient opening of the morphologic blood-brain barrier will occur. In the present study pressure increase, not sufficient in itself to cause barrier opening, was induced. However, at concomitant dilatation of the vessels--as induced by CO2 or papaverine--under otherwise identical pressure conditions a barrier opening was obtained. Hence, vasodilatation of cerebral vessels will increase their vulnerability to hypertension.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001812:Blood-Brain Barrier; D002339:Carotid Arteries; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D051381:Rats; D013194:Staining and Labeling; D014664:Vasodilation
chemical_list: D010208:Papaverine