Intracellular Ca2+ elevation induced by a neurotransmitter in a glial cell clone.
By fluorometry using a Ca2+-indicator Quin 2, we found an elevation of intracellular Ca2+ concentration ([Ca2+]i) in response to an application of serotonin in a rat clonal glial cell (C6BU-1). The [Ca2+]i rise depended on the dose of applied serotonin and the level of environmental Ca2+. The possibility was suggested that neuron-glia interactions might be controlled by a receptor-coupled [Ca2+]i-regulation system.
D000818:Animals; D002118:Calcium / Q000032:analysis* / Q000502:physiology; D002450:Cell Communication; D002999:Clone Cells; D009457:Neuroglia / Q000032:analysis* / Q000502:physiology; D009474:Neurons / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D018377:Neurotransmitter Agents; D012701:Serotonin; D002118:Calcium