Transgenic mice containing growth hormone fusion genes.
New genes composed of the mouse metallothionein I promoter-regulator and the rat or human growth hormone structural gene have been introduced into mice. A large proportion of mice containing these genes express them, and some animals grow to be up to twice as large as controls. The technique has been used in part to correct the genetic defect that results in the small stature of the mutant little mouse.
D000818:Animals; D005260:Female; D005796:Genes; D005809:Genes, Regulator; D013006:Growth Hormone / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D008297:Male; D008668:Metallothionein / Q000235:genetics*; D051379:Mice; D009154:Mutation; D010375:Pedigree; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D013006:Growth Hormone; D008668:Metallothionein