title: [Trial of the safety, reactivity and therapeutic effectiveness of an ointment containing swine leukocytic interferon].
abstract: An ointment containing porcine leucocytic interferon (PLI) with the use of lanolin as the base and addition of human serum albumin for stabilization of the antiviral activity and Tris-or Hepes-buffer solutions for stabilization of the medium pH value was studied. The trials on volunteers with herpetic affections of the face and genitalia showed absolute safety of the drug, its areactivity and sufficiently high therapeutic efficacy as compared to an ointment containing human leucocytic interferon. The positive effect was observed in 52 out of 78 patients. On the basis of these data the PLI may be recommended for further clinical trials.
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004361:Drug Tolerance; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D007372:Interferons / Q000009:adverse effects / Q000627:therapeutic use*; D007962:Leukocytes / Q000276:immunology; D008297:Male; D009824:Ointments; D013552:Swine
chemical_list: D009824:Ointments; D007372:Interferons
vernacular_title: Ispytanie bezvrednosti, reaktogennosti i lechebnoĭ éffektivnosti mazi, soderzhashcheí svinoĭ leikotsitarnyĭ interferon.