Biochemical interaction of six OP delayed neurotoxicants with several neurotargets.
Five organophosphorous insecticides: Leptophos, EPN, Cyanofenphos, trichloronate and salithion proved to cause irreversible ataxia not only to chicken but also to mice and sheep. TOCP was included as a reference. Cyanofenphos blocked the catecholamine B-receptor binding activity with 3H-norepinephrine at a level similar to that of the specific inhibitor propranolol in the mouse heart preparation. In the lamb heart preparation, the B-receptor was more sensitive to Leptophos, salithion and TOCP than to propranolol. The six compounds and their oxons were screened for their in-vitro inhibition to monamine oxidase (MAO), acetyl cholinesterase (AChE) and neurotoxic esterase (NTE) in the brain of either mouse, lamb or chicken. It is believed that their AChE inhibition stands for their acute toxicity, while NTE inhibition is responsible for their paralytic ataxia.
D000818:Animals; D001259:Ataxia / Q000139:chemically induced*; D001921:Brain / Q000187:drug effects*; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors; D002645:Chickens; D002800:Cholinesterase Inhibitors; D005260:Female; D006321:Heart / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D010773:Leptophos / Q000633:toxicity / Q000031:analogs & derivatives; D008297:Male; D051379:Mice; D009410:Nerve Degeneration / Q000187:drug effects; D009498:Neurotoxins; D010755:Organophosphates / Q000633:toxicity; D009943:Organophosphorus Compounds / Q000633:toxicity; D063086:Organothiophosphates / Q000633:toxicity; D009946:Organothiophosphorus Compounds / Q000633:toxicity; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester / Q000031:analogs & derivatives / Q000633:toxicity; D012756:Sheep
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009498:Neurotoxins; D010755:Organophosphates; D009943:Organophosphorus Compounds; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; C002488:cyanophenphos; C032085:EPN oxon; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; C004372:trichloronate; C032089:salioxon; C032070:salithion; C032088:cyanofenphos oxon; C032087:trichloronate oxon; C008265:leptophos oxon; D010773:Leptophos; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase