An 'on grid' electron microscopic method for studying the interaction and fusion of influenza A virus with human erythrocyte membranes.
An 'on grid' negative staining method was developed to study the interaction of influenza virus with erythrocyte membranes. The virus was reacted in situ with cells which had been immobilised on an electron microscope grid. Fusion between influenza virus and the membrane of erythrocyte ghosts was clearly seen using this method.
D004910:Erythrocyte Membrane / Q000502:physiology / Q000648:ultrastructure*; D004912:Erythrocytes / Q000648:ultrastructure*; D006801:Humans; D009980:Influenza A virus / Q000502:physiology / Q000648:ultrastructure*; D008854:Microscopy, Electron / Q000379:methods*; D013194:Staining and Labeling