[Inhibitory effect of combined administration of neuraminidase and interferon in mice with Rauscher leukemia].
A study was made of the effect of cholera vibrio neuraminidase and mouse interferon on the development of Rauscher's leukemia in BALB/c mice. It was shown that administration of 1500 units interferon to mice 4 hours before and 5 days after inoculation of Rauscher's leukemia virus prolonged the animals' lifespan. Preliminary treatment of the virus-containing material with neuraminidase prevented the death of one third of the experimental animals. Meanwhile the remainder of the animals inoculated with the same virus showed a longer lifespan. Combined use of both the preparations proved the most effective, enabling the prevention from death of 90% of the experimental animals. The mechanism of antiviral action of neuraminidase and interferon is discussed.
D000818:Animals; D004359:Drug Therapy, Combination; D007372:Interferons / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000627:therapeutic use*; D011925:Rauscher Virus
D007372:Interferons; D009439:Neuraminidase
Ingibiruiushchee deĭstvie sochetannogo primeneniia neĭraminidazy i interferona pri leĭkoze mysheĭ Raushera.