Cellular immunity in glomerulonephritis.
58 patients (25 with GN, 13 with PN, 10 with hypernephroma, and 10 healthy controls) were tested for t-cell activity against glomerular basement membrane antigen (GBMA), total renal antigen (TRA), hypernephroma antigen (HyA), HEP, and PPD by means of the electrophoretic mobility test described by Field and Caspary. Positive reactions to GMBA were demonstrated in 21 to 25 GN patients, and 2 of 13 PN patients. There was no reaction among the hypernephroma patients or the controls. Lymphocytes from all 10 hypernephroma patients, but only 1 of the other 37 patients tested, were sensitized against HyA. No conclusion may be drawn regarding the pathogenetic relevance of the findings, but attention is drawn to the diagnostic value of tests based on these results.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology
D000941:Antigens; D000951:Antigens, Neoplasm; D004676:Myelin Basic Protein; D014373:Tuberculin