Degeneration of retinal neuroblasts by chinoform-ferric chelate.
The possible mechanism of neuropathic effect of chinoform was investigated using cultured retinal neuroblasts from chick embryos. Retinal neuroblasts completely degenerated by chinoform-ferric chelate within a day. This change, however,, was not observed with free chinoform or ferric ion alpha-Tocopherol had a potent protective effect on the toxicity of the chelate. From these results, it was concluded that the lipid peroxidation due to ferric ion chelated with chinoform incorporated into the membrane of nerve tissues is the most important step in induction of the neuropathy.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D007464:Clioquinol / Q000494:pharmacology*; D004923:Erythrosine; D007502:Iron Chelating Agents / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D012160:Retina / Q000166:cytology / Q000196:embryology*; D013194:Staining and Labeling; D014810:Vitamin E / Q000494:pharmacology
D007502:Iron Chelating Agents; D014810:Vitamin E; D007464:Clioquinol; D004923:Erythrosine