title: A hypothesis on the possible role of interferon in the initiation of acute gouty arthritis attack.
abstract: There is some evidence that unidentified factors might play a role in the initial events of acute gouty arthritis. Serum interferon activity was found to be high in several arthritides; interferon stimulates the production of prostaglandin E, an established mediator of inflammation. It is postulated that interferon can play a role in the pathogenesis of an acute gouty arthritis.
mesh_terms: D000208:Acute Disease; D006073:Gout / Q000503:physiopathology*; D006801:Humans; D007372:Interferons / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D008954:Models, Biological; D010587:Phagocytosis; D011458:Prostaglandins E / Q000096:biosynthesis; D013582:Synovial Fluid / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
chemical_list: D011458:Prostaglandins E; D014527:Uric Acid; D007372:Interferons