Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones.
The receptor-mediated endocytosis of alpha 2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.
D000588:Amines / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D003260:Contact Inhibition; D006224:Cricetinae; D004705:Endocytosis / Q000187:drug effects; D006728:Hormones / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D010455:Peptides; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism*; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000588:Amines; D006728:Hormones; D008565:Membrane Proteins; D010455:Peptides; D011955:Receptors, Drug; D000511:alpha-Macroglobulins; D005723:gamma-Glutamyltransferase