[Effect of tetrodotoxin and ethmozine on arrhythmias of a dog heart isolated in the late stage of experimental myocardial infarct].
Dog hearts with ventricular extrasystole that developed 24 hours after coronary artery occlusion were isolated and perfused with blood from support dogs. After heart isolation the rhythm disturbances persisted regardless the decreased frequency of the ventricular beats. Administration of tetrodotoxin (4 X 10-8--10-7 g/ml) and ethmozine (3--5X X10-5 g/ml) abolished ventricular arrhythmias and restored the sinus rhythm. Potential mechanisms of the increased susceptibility of ischemic myocardial fibers to tetrodotoxin and antiarrhythmic drugs are discussed.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D066298:In Vitro Techniques; D016293:Moricizine; D009025:Morpholines / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000150:complications*; D010640:Phenothiazines / Q000627:therapeutic use*; D013779:Tetrodotoxin / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D009025:Morpholines; D010640:Phenothiazines; D016293:Moricizine; D013779:Tetrodotoxin
Vliianie   tetrodotoksina i étmozina na aritmii serdtsa sobaki, izolirovannogo v pozdneĭ stadii éksperimental'nogo infarkta miokarda.