[Interstrain differences in the serotonin and 5-hydroxyindoleacetic acid levels in the postnatal ontogeny of C57BL/6J and BALB/cLac strain mice].
The content of serotonin and 5-hydroxy-indole-acetic acid (5-HIAA) was determined in the brain stem and hemispheres in 1 and 3 months old C57BL/6J and BALB/cLac mice. The characteristic dynamics of serotonin and its metabolite content related to the age was found in different brain regions and proved to be similar in both the strains, but the rate of serotonin system development in C57BL/6J mice was higher than in BALB/c Lac mice. An intensive catabolism of serotonin, possibly, related to the reaction to new environment was noted in the newborn animals. Sex differences in the rate of serotonin system maturation and serotonin and 5-HIAA content were shown for 12--16 days old mice: 12 days old males were characterized by more intensive metabolism than females while 16 days old males had less serotonin than females.
D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry; D001933:Brain Stem / Q000032:analysis; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000254:growth & development* / Q000378:metabolism; D008810:Mice, Inbred C57BL / Q000254:growth & development* / Q000378:metabolism; D012701:Serotonin / Q000032:analysis*; D012737:Sex Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid
Mezhlineĭnye razlichiia v urovne serotonina i 5-gidorksiindoluksusnoĭ kisloty v postnatal'nom ontogeneze mysheĭ liniĭ C57BL/6J i BALB/cLac.