title: Induction of IgM memory with RNA from the spleens of immunized mice.
abstract: Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming cell (PFC) assay. IgM antibody formation was markedly higher in iRNA-treated than in any other mice. The effect of iRNA was antigen-specific and similar materials from non-immunized mice had no activity.
mesh_terms: D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes / Q000032:analysis; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007156:Immunologic Memory / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D012313:RNA / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
chemical_list: D000939:Epitopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012313:RNA