[Proliferation of the secretory cells of the pancreatic islets of white rats and mice].
Endocrine cells proliferation in the pancreas of white rats and mice during the postnatal period of ontogenesis (1-365 days) and daily fluctuations of RNA synthesis and mitotic activity in mature animals have been studied by means of radioautographic and statmokinetic methods. A sharp decrease in reproductive activity of the islet cells is noted during the investigation. The pancreatic islet cells in mature white rats and mice demonstrate a low level of the proliferative activity. The maximal mitotic coefficient (0.03%) is noted in the evening and at night. the greatest index of 3H-thymidine labelling (0.44%) is noted at 4 P.M.
D000818:Animals; D002940:Circadian Rhythm; D004247:DNA / Q000096:biosynthesis; D007515:Islets of Langerhans / Q000166:cytology* / Q000254:growth & development; D008297:Male; D051379:Mice; D008938:Mitosis; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013936:Thymidine / Q000378:metabolism
D012313:RNA; D004247:DNA; D013936:Thymidine
Proliferatsiia sekretornykh kletok pankreaticheskikh ostrovkov belykh krys i mysheĭ.