title: Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control.
abstract: Power spectrum analysis of heart rate fluctuations provides a quantitative noninvasive means of assessing the functioning of the short-term cardiovascular control systems. We show that sympathetic and parasympathetic nervous activity make frequency-specific contributions to the heart rate power spectrum, and that renin-angiotensin system activity strongly modulates the amplitude of the spectral peak located at 0.04 hertz. Our data therefore provide evidence that the renin-angiotensin system plays a significant role in short-term cardiovascular control in the time scale of seconds to minutes.
mesh_terms: D000809:Angiotensins / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena; D003201:Computers; D004285:Dogs; D004791:Enzyme Inhibitors; D006024:Glycopyrrolate / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008722:Methods; D009599:Nitroprusside / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D012083:Renin / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D013722:Teprotide
chemical_list: D000809:Angiotensins; D004791:Enzyme Inhibitors; D009842:Oligopeptides; D009599:Nitroprusside; D011433:Propranolol; D013722:Teprotide; D012083:Renin; D006024:Glycopyrrolate