[Effect of glutamic acid on the course of recovery processes in the adrenal cortex].
Glutamic acid in a dose of 1/100 of the LD50 was injected in the form of sodium salt into male and female Wistar rats for 7 days after 8- and 12-day injections of dexazone. During the first 3 days of injections, female rats received a low dexazone dose (5 micrograms/100 g bw). Injection of glutamic acid in conjunction with dexazone reduced the inhibitory effect of the latter drug on the adrenals but did not avert its inhibitory effect on the central nervous system. Prolonged injections of glutamic acid after dexazone treatment promoted more rapid and more complete recovery of adrenal function.
D015062:11-Hydroxycorticosteroids / Q000378:metabolism; D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000309:Adrenal Insufficiency / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D003907:Dexamethasone / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005260:Female; D005971:Glutamates / Q000627:therapeutic use*; D018698:Glutamic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D015062:11-Hydroxycorticosteroids; D005971:Glutamates; D018698:Glutamic Acid; D003907:Dexamethasone
Vliianie glutaminovoĭ kisloty na techenie vosstanovitel'nykh protsessov v kore nadpochechnikov.