Oligoclonal gamma-globulin of cerebrospinal fluid in neurobrucellosis.
The clinical manifestations and laboratory findings of two cases of neurobrucellosis are described. The cerebrospinal fluid (CSF) protein electrophoresis showed increased gamma-globulins and decreased relative values of pre-albumin and albumin, associated to high values of total CSF protein. The evidence of oligoclonal morphology of CSF gamma-globulins suggests that part of them had an intrathecal origin, in addition to an increased crossing of the damaged blood-CSF barrier. Similar oligoclonal appearance of CSF gamma-globulins was observed in two additional cases of neurobrucellosis previously reported.
D002006:Brucellosis / Q000134:cerebrospinal fluid*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009461:Neurologic Manifestations; D005719:gamma-Globulins / Q000134:cerebrospinal fluid*
D002556:Cerebrospinal Fluid Proteins; D005719:gamma-Globulins