Cutaneous histamine-releasing activity of dimethylsulphoxide (DMSO) in guinea pigs.
Dimethylsulphoxide (DMSO) induced swelling in guinea pig ears was found to be abolished by H1- and H2-receptor blocking agents. On histological examination of the ears some degranulation of mast cells was seen. It was concluded that the swelling was mediated by histamine release.
D000818:Animals; D004121:Dimethyl Sulfoxide / Q000633:toxicity*; D004423:Ear / Q000033:anatomy & histology / Q000187:drug effects; D004487:Edema / Q000139:chemically induced; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism
D004121:Dimethyl Sulfoxide