Antigen-specific production of immune interferon by T Cells lines.
Continuous cultures of T cells reactive to the hapten 4-ethoxymethylene-2-phenyloxazolone were tested for interferon production after antigenic stimulation in vitro. Induction of interferon was antigen-specific and also restricted by the I region of the major histocompatibility complex. Kinetics of antigen induced interferon production were different from those reported for mitogen induced synthesis.
D000818:Animals; D002460:Cell Line; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes; D007372:Interferons / Q000096:biosynthesis* / Q000276:immunology; D007700:Kinetics; D008285:Major Histocompatibility Complex; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010081:Oxazolone / Q000276:immunology; D013601:T-Lymphocytes / Q000378:metabolism*
D000939:Epitopes; D010081:Oxazolone; D007372:Interferons