Thrombin inhibitors in women on oral contraceptives.
Progressive antithrombin activity and the immunological levels of antithrombin III, alpha 2-macroglobulin, and alpha 1-antitrypsin were measured in women at various intervals during treatment with oral contraceptives and in a group of untreated women. No significant changes were observed in any of the above parameters. In both control and treated women, there was a positive statistical correlation between progressive antithrombin activity and antithrombin III immunological levels, whereas no correlation was found between the former and alpha 1-antitrypsin or alpha 2-macroglobulin immunological levels. This study questions the possibility of thrombin inhibitors being selective signs of hypercoagulability during treatment with oral contraceptives.
D000293:Adolescent; D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D000991:Antithrombins / Q000378:metabolism*; D003276:Contraceptives, Oral / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008598:Menstruation; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D000991:Antithrombins; D003276:Contraceptives, Oral; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D000990:Antithrombin III; D005340:Fibrinogen