Opposite effects of lorazepam on two kinds of myoclonus in the photosensitive Papio papio.
The action of lorazepam was studied in photosensitive baboons. Animals were either naturally very photosensitive or rendered photosensitive by a previous injection of allylglycine. Intravenous administration of varying doses, from 0.05 to 0.5 mg/kg, of lorazepam blocked the myoclonus induced by intermittent light stimulation in all the animals. However, in the naturally photosensitive baboon the injection of lorazepam favoured the appearance of spontaneous myoclonus with no important EEG modification. This myoclonus is different from that induced by intermittent light stimulation, which is always preceded by spike-wave cortical discharges. Lorazepam-induced myoclonus appears during the period when the animal is not photosensitive and its origin is probably in the medulla or in the brain stem.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000188:drug therapy*; D005071:Evoked Potentials / Q000187:drug effects; D008140:Lorazepam / Q000097:blood / Q000627:therapeutic use*; D010215:Papio; D010775:Photic Stimulation; D012640:Seizures / Q000188:drug therapy*
D014151:Anti-Anxiety Agents; D008140:Lorazepam