title: Does substance P participate in water transport and excretion?
abstract: Substance P is located in wide distribution in the central nervous system and synthesized, stored and released like other classical neurotransmitters. There is theoretical and experimental evidence that substance P may regulate water excretion by at least two different mechanisms. The peptide may control water metabolism by renal and central nervous system actions.
mesh_terms: D000818:Animals; D010856:Columbidae; D004285:Dogs; D004327:Drinking Behavior / Q000187:drug effects; D051381:Rats; D013373:Substance P / Q000502:physiology*; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water; D013373:Substance P