[Effect of the protease inhibitor contrical on oxidative phosphorylation and proteolysis in kidney under thermal ischemia].
Morphological (at the tissue, cellular and subcellular levels) and biochemical (determination of the autolysis intensity, proteolytic activity for casein and BAPNA splitting, the level of oxidation phosphorylation) methods were used to show that a preliminary administration to the animal organism of contrical, an inhibitor of proteases partially prevents the kidneys, which endured a two-hour ischemia from development of irreversible changes, favours the preservation of the renal parenchyma structure, and stabilizes the energy status of cells.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D006358:Hot Temperature; D007511:Ischemia / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply / Q000378:metabolism* / Q000648:ultrastructure; D007700:Kinetics; D008297:Male; D008854:Microscopy, Electron; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D011506:Proteins; D007611:Aprotinin
Vliianie ingibitora proteaz kontrikala na okislitel'noe fosforilirovanie i proteoliz v pochkakh pri teplovoĭ ishemii.