Acute generalized pustular bacterid and immune complexes.
The case is described of a 39-year-old man with acute generalized pustular bacterid and high Clq-binding activity in the sera during the active stage. Histamine-induced vascular changes studied by immunofluorescence microscopy revealed a perivascular deposition of IgM and C3. These findings support the view that leukocytoclastic vasculitis underlying the subcorneal pustules is mediated by immune complex deposition.
D000328:Adult; D000936:Antigen-Antibody Complex; D001424:Bacterial Infections / Q000276:immunology* / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006229:Hand Dermatoses / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D012867:Skin / Q000276:immunology / Q000473:pathology; D012874:Skin Diseases, Infectious / Q000276:immunology* / Q000473:pathology; D013492:Suppuration
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007075:Immunoglobulin M