Effect of alinidine on experimental cardiac arrhythmias.
Alinidine (2.9 +/- 0.7 mg/kg) prevented an adrenaline-induced ventricular arrhythmia in dogs respired with halothane. In ouabain-induced ventricular tachycardia, a cumulative dose of alinidine (15.5 mg/kg) reduced the number of ventricular beats by 91.6 +/- 1.9%. The drug was much less effective in abolishing the ventricular tachycardia 24 h after ligation of a coronary artery, with only a 36 +/- 15% reduction in ventricular ectopic beats after 15.5 mg/kg. The administration of alinidine (0.5-1.0 mg/kg) to anaesthetized dogs with no cardiac arrhythmia reduced sinus node rate with little effect on the response of the node to vagal stimulation.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D004837:Epinephrine; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D012849:Sinoatrial Node / Q000502:physiology
D000889:Anti-Arrhythmia Agents; D010042:Ouabain; C022192:alinidine; D003000:Clonidine; D006221:Halothane; D004837:Epinephrine