title: [Antiviral activity of modified RNAses].
abstract: Antiviral activity of pancreatic RNase and RNase from Act.rimosus modified by various dextran derivatives was studied with respect to aphthosa and Ayzeku disease viruses. Antiviral activity of pancreatic RNase modified by dextran m-aminobenzylhydroxymethyl ether was lower than biological activity of RNase from Act.rimosus modified by the same dextran. Antiviral activity of pancreatic enzyme modified by dialdehyde dextran also changed insignificantly. Modification by dextran hydroxyethylsulfonylanisole ether, dextran m-aminobenzylhydroxymethyl ether in the presence of pyridine or dextran sulfate resulted in a more pronounced increase in antiviral activity of pancreatic enzyme. Therefore, biological activity of the modified nucleases depended on the nature of the enzyme and dextran modifying it.
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D005537:Aphthovirus / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004720:Endonucleases / Q000494:pharmacology*; D004987:Ethers / Q000494:pharmacology; D005536:Foot-and-Mouth Disease / Q000188:drug therapy; D011558:Herpesvirus 1, Suid / Q000187:drug effects; D051379:Mice; D010179:Pancreas / Q000201:enzymology; D011485:Protein Binding / Q000187:drug effects; D006163:Ribonuclease T1 / Q000494:pharmacology*; D012259:Ribonuclease, Pancreatic; D012260:Ribonucleases / Q000494:pharmacology*; D013302:Streptomyces / Q000201:enzymology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D003911:Dextrans; D004987:Ethers; D004720:Endonucleases; D012260:Ribonucleases; D006163:Ribonuclease T1; D012259:Ribonuclease, Pancreatic
vernacular_title: Protivovirusnaia aktivnost' modifitsirovannykh RNK-az.