Prolonged suppression of experimental allergic encephalomyelitis in the Lewis rats: the effect of lipopolysaccharides.
The current investigations have revealed that Lewis rats preimmunized with BP in CFA, and after recovery from the first episode of EAE, developed a second mild attack of EAE after challenge with BP/CFA at specified times. However, preimmunization of Lewis rats with BP complexed to LPS in CFA protects animals for a longer time from a second attack induced by BP/CFA challenge.
D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000276:immunology / Q000627:therapeutic use*; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D004676:Myelin Basic Protein