title: Resistance to thiostrepton, siomycin, and sporangiomycin in actinomycetes that produce them.
abstract: The antibiotics thiostrepton, siomycin, and sporangiomycin are closely related both in structure and in mode of action. Actinomycetes which produce this group of compounds possess ribonucleic acid-pentose methylases, which act upon 23S ribosomal ribonucleic acid and render ribosomes resistant to the action of these antibiotics. This is achieved via the formation of a single residue of 2'-O-methyladenosine per ribosome.
mesh_terms: D000192:Actinomycetales / Q000187:drug effects* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D036341:Intercellular Signaling Peptides and Proteins; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology; D012329:RNA, Bacterial / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D013302:Streptomyces / Q000187:drug effects* / Q000378:metabolism; D013883:Thiostrepton / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; C025311:siomycin; C003339:sporangiomycin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; D013883:Thiostrepton