Prevention of the platelet alpha-granule release reaction by membrane-active drugs.
A range of membrane-active drugs were tested for their ability to prevent beta-thromboglobulin and platelet factor 4 release from freshly collected blood platelets. While all the drugs tested could inhibit collagen-induced platelet aggregation, only a few, notably procaine and the anti-malarial drugs chloroquine, hydroxychloroquine, camoquine and quinacrine (mepacrine), effectively prevented the alpha-granule release reaction.
D000527:Alprostadil; D000925:Anticoagulants / Q000494:pharmacology; D001609:Beta-Globulins / Q000378:metabolism*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects; D003594:Cytoplasmic Granules / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004492:Edetic Acid / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006886:Hydroxychloroquine / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010978:Platelet Factor 4 / Q000378:metabolism*; D011343:Procaine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D013696:Temperature; D013806:Theophylline / Q000494:pharmacology; D001620:beta-Thromboglobulin / Q000378:metabolism*
D000925:Anticoagulants; D001609:Beta-Globulins; D001779:Blood Coagulation Factors; D010879:Piperazines; D011458:Prostaglandins E; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D006886:Hydroxychloroquine; D011343:Procaine; C006589:piperazine citrate; D004492:Edetic Acid; D011433:Propranolol; D013806:Theophylline; D000527:Alprostadil