title: [Pregnancy,-associated alpha 2-glycoprotein (alpha 2-PAG): a possible marker for tumor monitoring?].
abstract: To comment on the recurrence of tumours and metastasis the long term studies of the alpha 2-PAG determination in sera of patients with carcinoma of the breast, bronchial carcinoma, gynaecological carcinoma, melanomas have proved as a possible laboratory parameter. The results published till the present time on trophoblastic tumours and gastrointestinal carcinoma are still divergent. Because of the large individual range of alpha 2-PAG concentrations and because of the widely differing alpha 2-PAG levels in men and women single determinations of this protein are without value. Still missing is a detailed clarification of pathological mechanisms to which this protein is submitted and thereby a fundamental knowledge of diseases which lead apart from pregnancy and neoplasiae to changes in the physiological alpha 2-PAG serum sample.
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy; D001984:Bronchial Neoplasms / Q000628:therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000628:therapy; D008137:Longitudinal Studies; D008297:Male; D008545:Melanoma / Q000628:therapy; D009362:Neoplasm Metastasis / Q000175:diagnosis; D000511:alpha-Macroglobulins / Q000097:blood*
chemical_list: D000511:alpha-Macroglobulins
vernacular_title: Das schwangerschaftsassoziierte alpha 2 Glykoprotein (alpha 2 PAG) Ein möglicher Marker zur Tumorverlaufskontrolle?