[Induction of alpha-fetoprotein synthesis in nonproliferating hepatocytes].
The localization of alpha-fetoprotein (alpha-FP) and the proliferative activity of hepatocytes were studied after an insignificant liver damage. On the 3rd--6th day after the operation alpha-FP was detectable in hepatocytes localized on the boundary with the zone of damage. The most intensely stained cells were found adjacent to some vessels lying near this zone. The overwhelming majority of alpha-FP-containing hepatocytes did not incorporate 3H-thymidine. The data obtained allow a conclusion that the synthesis of alpha-FP is not related to cell proliferation.
D000818:Animals; D005260:Female; D006498:Hepatectomy; D007124:Immunoenzyme Techniques; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008938:Mitosis; D013936:Thymidine / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins; D013936:Thymidine
Induktsiia sinteza alpha-fetoproteina v neproliferiruiushchikh gepatotsitakh.