title: Early changes in serum protein and liver LDH isoenzymes in mice exposed to technical grade hexachlorocyclohexane (BHC) and their possible relationship to liver tumours.
abstract: Mice were exposed to hexachlorocyclohexane (BHC) in order to study the changes in the serum protein pattern and in the LDH isoenzymes of the liver. After 2 months of exposure the protein pattern showed a new band which persisted even after the development of a tumour. The LDH isoenzymes pattern showed a gradual decrease of the faster moving LDH-1 and LDH-2 bands which later disappeared completely when hepatic tumours formed. The significance of these results is discussed.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D007527:Isoenzymes; D001556:Hexachlorocyclohexane; D007770:L-Lactate Dehydrogenase