The effect of captopril on plasma histamine and histamine release in vitro.
Plasma histamine and the release of histamine from blood in vitro has been determined in patients being treated for hypertension or heart failure with captopril. This drug does not alter plasma histamine levels in either group of patients or release histamine from human basophils, rat peritoneal mast cells or guinea pig lung slices upon challenge in vitro. We conclude that histamine release does not contribute to the cardiovascular or side effects of captopril.
D000328:Adult; D000368:Aged; D002216:Captopril / Q000494:pharmacology*; D006333:Heart Failure / Q000097:blood; D006632:Histamine / Q000097:blood*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D006973:Hypertension / Q000097:blood; D008407:Mast Cells / Q000378:metabolism; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*; D012882:Skin Tests
D006632:Histamine; D011392:Proline; D002216:Captopril