title: [Electronmicroscopic study on the molecular shape of non-stabilized fibrin break-down products produced by complex heparin compounds].
abstract: Experimental data indicate that products develop from non-stabilized fibrin because of nonfermentative splitting by complex heparin connections. These products have a globular form with a diameter of 10-250 A and are similar to morphological fibrinogen molecules. The identified products show no marked lytic effect towards non-stabilized fibrin. The application of S35 labelled heparin in combination with preparative ultracentrifugation and electron microscopy enabled the determination to be established that heparin complexes will combine with particles of fibrinomeres, thus causing their transfer from the fibrillary to the globular condition. The destruction of the connections of heparin complexes with their globular molecule structures of fibrinmonomere, e.g. by protamine sulfate, guarantees their development and primary polymerization. With factor XIIIa being present, the structurally reconstructed fibrin will form a stabilized coagulum of full value which is similar in its ultrastructure to fibrin obtained in control tests.
mesh_terms: D004837:Epinephrine; D005338:Fibrin Fibrinogen Degradation Products; D006493:Heparin; D006801:Humans; D008854:Microscopy, Electron; D008968:Molecular Conformation; D014508:Urea
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D014508:Urea; D006493:Heparin; D004837:Epinephrine
vernacular_title: Elektronenmikroskopische Untersuchung der Molekülformen von Spaltprodukten nichtstabilisierten Fibrins durch komplexe Heparinverbindungen.