Antibodies to P2 and P1 myelin antigens in experimental allergic neuritis and allergic encephalomyelitis.
We confirmed earlier observations that experimental allergic neuritis (EAN) in Lewis rats induced by injection of bovine peripheral nerve myelin in complete Freund's adjuvant is not accompanied by development of experimental allergic encephalomyelitis. However, sera of these animals contained elevated titers of antibodies against central nervous system myelin basic protein (BP), likely induced by peripheral nerve P1 protein. Anti-BP antibodies were not seen in sera of rats with EAN induced by peripheral nerve P2 protein. Lack of encephalogenicity of bovine myelin in Lewis rats does not reflect simply lack of immune responses induced against BP.
D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D000941:Antigens / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006168:Guinea Pigs; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology; D009185:Myelin Proteins / Q000276:immunology*; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology*; D010525:Peripheral Nerves / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew
D000906:Antibodies; D000941:Antigens; D004676:Myelin Basic Protein; D009185:Myelin Proteins