Fatal pulmonary bleomycin toxicity in cisplatin-induced acute renal failure.
A 53-year-old male being treated for a metastatic squamous cell carcinoma had fatal pulmonary toxicity as a result of bleomycin therapy. The toxic reaction was observed when the conventional dose regimen of bleomycin was given to the patient who had unrecognized cisplatin-induced acute renal failure. Bleomycin dosage should be reduced in patients with established acute renal failure and the combination of cisplatin and bleomycin should be carefully followed.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
D001761:Bleomycin; D002945:Cisplatin