Dissociation between interferon production induced by phytohemagglutinin and concanavalin A in spleen cell cultures of nude mice.
Spleen cells of homozygous nude mice did not react with lymphoproliferation to both phytohemagglutinin (PHA) and concanavalin A (Con A), and there was no detectable interferon production in response to Con A. However, PHA-induced interferon production was equal in spleen cells of nu/nu mice and nu/+ mice. One possible explanation for these findings is that a subset of T cells responds to PHA with interferon production different from that responding to Con A with interferon production.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D051379:Mice; D008819:Mice, Nude; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013154:Spleen
D007369:Interferon Inducers; D010835:Phytohemagglutinins; D003208:Concanavalin A; D007372:Interferons