Effects of contrast media on aortic endothelium. Experiments in the rat with non-ionic monomeric and monoacidic dimeric contrast media.
Injury to the aortic endothelium in rats was evaluated under a light microscope by a silver staining method after application of ionic monomeric (diatrizoate and metrizoate), non-ionic monomeric (C29 with different pH and buffers, 593, iohexol and metrizamide) and monoacidic dimeric (ioxaglate) contrast media, and iso- and hypertonic solutions of sodium chloride. In iodine equivalent concentrations the ionic monomers were significantly more toxic than the other contrast media. No significant was found between the non-ionic monomers, monoacidic dimer and sodium chloride solutions equiosmolal to the ionic monomers. Isotonic saline was the least harmful solution.
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004727:Endothelium / Q000166:cytology; D007463:Iodobenzoates / Q000494:pharmacology*; D007472:Iohexol; D007479:Iopamidol / Q000031:analogs & derivatives*; D007483:Iothalamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007485:Ioxaglic Acid; D008297:Male; D008536:Meglumine / Q000494:pharmacology; D008793:Metrizamide / Q000494:pharmacology; D008794:Metrizoic Acid / Q000494:pharmacology; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling / Q000379:methods; D014283:Triiodobenzoic Acids / Q000494:pharmacology*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; D007472:Iohexol; D008536:Meglumine; C020687:C 29 (contrast media); D008794:Metrizoic Acid; D007479:Iopamidol; D008793:Metrizamide; D007485:Ioxaglic Acid