title: [Review. Endotoxins and blood coagulation].
abstract: The impact of blood coagulation caused by endotoxins (ET) is reported in a survey. In this connection the activation of factor XII by ET and the activation of the intrinsic system of coagulation due to it are discussed, the mechanism of blood platelet damage with subsequent thrombocytopenia is dealt with, and the induction for liberating of a thromboplastin-like procoagulant from leukocytes as well as the factors influencing this liberation are described. Furthermore, the mechanisms leading to the damage of the endothelia cell are discussed and the correlations to the complement system are described. On the basis of facts known up till now special attention is devoted to the role of the thromboplastin-like procoagulant and the activation of the extrinsic system caused by it in developing a DIC syndrome.
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects; D003167:Complement Activation / Q000187:drug effects; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D004727:Endothelium / Q000187:drug effects; D004731:Endotoxins / Q000009:adverse effects*; D005167:Factor VII / Q000502:physiology; D005174:Factor XII / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D013925:Thromboplastin / Q000096:biosynthesis
chemical_list: D004731:Endotoxins; D005167:Factor VII; D005174:Factor XII; D013925:Thromboplastin
vernacular_title: Ubersicht. Endotoxine und Blutgerinnung.