title: [Mouse macrophage interferons].
abstract: Mouse peritoneal macrophages produce two types of interferon: type 1 interferon resistant to pH 2.0 is produced in response to the inoculation of virus and poly(I) . poly(C), type 2 interferon (immune), sensitive to pH 2.0 is induced by phytohemagglutinin and is formed due to phagocytosis of sheep erythrocytes treated with specific antiserum. The virus-induced interferon is produced by macrophages very rapidly (maximum within 1-2 hours), and the antiviral state resulting from it develops within 1-3 hours after inoculation of the inducer. Immunization of mice as well as pretreatment of macrophages with small doses of interferon did not affect their interferon-synthesizing activity. Type 2 interferon produced a marked antiproliferative effect in L cell culture.
mesh_terms: D000818:Animals; D003637:DEAE-Dextran / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007114:Immunization; D007372:Interferons / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009522:Newcastle disease virus / Q000276:immunology; D010587:Phagocytosis; D010835:Phytohemagglutinins / Q000494:pharmacology; D011070:Poly I-C / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology
chemical_list: D010835:Phytohemagglutinins; D007372:Interferons; D003637:DEAE-Dextran; D011070:Poly I-C
vernacular_title: Makrofagal'nye interferony mysheĭ.