Total and SHBG-bound testosterone and 5 alpha-dihydrotestosterone serum concentrations in normal elderly men and patients with benign prostatic hypertrophy before and after removal of the adenoma.
Serum testosterone, 5 alpha-dihydrotestosterone and their binding by sex hormone binding globulin (SHBG) were quantified in 10 patients with prostatic hypertrophy, before and after retropubic prostatectomy, and in an age-matched control group. Testosterone was significantly higher in the sera of the BPH patients. The SHBG-bound testosterone and 5 alpha-dihydrotestosterone were identical in both groups, but the fraction of testosterone and 5 alpha-dihydrotestosterone not bound to SHBG was higher in the group with BPH. Therefore patients with prostatic hypertrophy are exposed to increased androgen action. Prostatectomy did not lead to significant changes in serum testosterone, 5 alpha-dihydrotestosterone or their binding to SHBG.
D000368:Aged; D013196:Dihydrotestosterone / Q000097:blood*; D006801:Humans; D008297:Male; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000601:surgery; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*
D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone