Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen.
Several recently isolated monoclonal antibodies which reacted with simian virus 40 T antigens also reacted with proteins found in uninfected and untransformed cells. The proteins were different from each other, PAb419 reacting with a 35,000-molecular-weight protein, PAb427 reacting with a 75,000-molecular-weight phosphoprotein, PAb405 reacting with a 150,000-molecular-weight phosphoprotein, and PAb204 reacting with a 68,000-molecular-weight protein. It is suggested that although some of these cross-reactions may be fortuitous, they may, as an alternative, reflect similarities of shape and perhaps function between domains of the viral T antigen and the relevant host proteins.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology*; D000957:Antigens, Viral, Tumor; D002460:Cell Line; D002522:Chlorocebus aethiops; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008394:Marsupialia; D051379:Mice; D010750:Phosphoproteins / Q000276:immunology; D011506:Proteins / Q000276:immunology*; D013539:Simian virus 40 / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor; D000939:Epitopes; D010750:Phosphoproteins; D011506:Proteins