Muscle relaxation with an infusion of vecuronium.
Vecuronium was administered by a continuous intravenous infusion following a bolus dose of 0.1 mg kg-1 in 10 patients. Following recovery of twitch height to 10% of control, steady state dose requirement for maintaining a 90% block was attained in an average of 15.4 min. The average dose required was 0.083 mg kg-1 h-1 or 3.27 mg m-2 h-1. Large individual variations were observed but each patient required an approximately constant dose over periods up to 4.5 h. Recovery was prompt following cessation of infusion.
D000328:Adult; D000758:Anesthesia; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009126:Muscle Relaxation; D009466:Neuromuscular Blocking Agents; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013514:Surgical Procedures, Operative; D014673:Vecuronium Bromide
D009466:Neuromuscular Blocking Agents; D014673:Vecuronium Bromide; D010197:Pancuronium