Orcein-positive hepatitis B surface antigen and liver carcinoma: their association in an Eastern US population.
We retrospectively examined the association of hepatitis B infection and hepatocellular carcinoma (HCC) in a US East Coast population using orcein staining of fixed liver tissue. Hepatitis B surface antigen (HBsAg) was present in non-neoplastic hepatocytes in eight of 53 cases of HCC, but in no cases of cholangiocarcinoma or metastatic tumor. In five of the eight positive cases, macronodular cirrhosis was present; in three positive cases, cirrhosis was absent. The rate of positivity in livers with both HCC and macronodular cirrhosis was 28%, compared with 4.7% in livers with macronodular cirrhosis but no carcinoma. The low, but significant association of HBsAg and HCC, both in the presence and absence of cirrhosis, suggests that HCC may develop in a subset of patients in the United States as a result of infection with hepatitis B virus.
D002759:Adenoma, Bile Duct / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology*; D008297:Male; D010078:Oxazines; D012189:Retrospective Studies; D013194:Staining and Labeling
D006514:Hepatitis B Surface Antigens; D010078:Oxazines; C002313:PAcein