Delivery of antiviral chemotherapeutic agents to neurons by retrograde axonal transport.
It may be possible to eliminate herpes simplex or zoster viruses from the neurons of carriers by treatment with an antiviral chemotherapeutic agent such as adenine arabinoside, ribavirin or acyclovir, coupled to a compound such as horseradish peroxidase that undergoes retrograde axonal transport.
D000212:Acyclovir; D001370:Axonal Transport; D055598:Chemical Phenomena; D002621:Chemistry; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006561:Herpes Simplex / Q000188:drug therapy*; D006562:Herpes Zoster / Q000188:drug therapy*; D006735:Horseradish Peroxidase / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D010544:Peroxidases / Q000627:therapeutic use*; D012254:Ribavirin / Q000627:therapeutic use; D014740:Vidarabine / Q000627:therapeutic use*
D012254:Ribavirin; D006147:Guanine; D006735:Horseradish Peroxidase; D010544:Peroxidases; D014740:Vidarabine; D000212:Acyclovir