Assessment of haemodynamic changes and acid-base equilibrium during hypovolaemia and after infusion of plasma substitutes in dogs.
The following haemodynamic values were determined in anaesthetized mongrel dogs: heart rate, systolic blood pressure in the ascending aorta, left ventricular pressure at the peak dp/dt, left ventricular end-diastolic pressure, time interval from Q in ECG to the onset of the systolic wave of dp/dt, time interval from Q in ECG to peak dp/dt, maximum rate of left ventricular pressure rise, femoral arterial flow, and certain indices of left ventricular contractility. It was concluded from the results of these experiments that infusion of a modified gelatin solution Fluigel prevented haemodynamic and metabolic changes produced by experimental hypovolaemia more effectively than infusion of Plasmagel.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D001810:Blood Volume; D001815:Bloodletting; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005780:Gelatin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D006470:Hemorrhage / Q000188:drug therapy / Q000503:physiopathology; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000494:pharmacology*
D003911:Dextrans; D010952:Plasma Substitutes; C025916:modified fluid gelatins; C025915:plasmagel; D005780:Gelatin