Antagonism of gamma-hydroxybutyric acid-induced frequency shifts in the cortical EEG of rats by dipropylacetate.
An automated technique for the continuous analysis of selected EEG frequency bands as a function of drug treatment is described. Experiments utilizing this analytical method have shown that the convulsive effects of GHB are antagonized by dipropylacetate, but that the effects of GHB exhibit a latent irreversibility.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004569:Electroencephalography / Q000379:methods; D006885:Hydroxybutyrates / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D012978:Sodium Oxybate; D014635:Valproic Acid / Q000494:pharmacology*
D006885:Hydroxybutyrates; D014635:Valproic Acid; D012978:Sodium Oxybate