title: [Study of the volt-ampere characteristics of ion channels by transmembrane current harmonics].
abstract: A method is proposed for measuring the coefficient of non--linearity beta of current--voltage characteristics of the class i (U) approximately U (1 + beta U2) of ionic channels formed by grammicidine A (Gra) and amphotericine B by the 3rd harmonics of the membrane current. For Gra A beta depends on the concentration of electrolyte c increasing lg c from -17 B-2 at 0.03 M to 8 B-2 at 3.4 M KCl turning to 0 at c0 = 0.3 divided by 1 M. The membranes of egg lecithin and glycerylmonooleate (GMO) differ in c0 value. Substitution of K+ ion for Li+, of the membrane solvent (n-heptane for n-hexadecane) and freezing of the GMO membrane do not affect beta.
mesh_terms: D000666:Amphotericin B; D055598:Chemical Phenomena; D002621:Chemistry; D004553:Electric Conductivity; D005989:Glycerides; D006096:Gramicidin; D007473:Ion Channels; D008094:Lithium; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D011188:Potassium
chemical_list: D005989:Glycerides; D007473:Ion Channels; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D006096:Gramicidin; D000666:Amphotericin B; D008094:Lithium; C005953:monoolein; D011188:Potassium
vernacular_title: Izuchenie vol't-ampernykh kharakteristik ionnykh kanalov po garmonikam transmembrannogo toka.