[Theoretical-experimental study of the process of phage lysis].
The mathematical model of phagolytic process is proposed, taking into account the preexponential phase in the growth of the biomass of bacteria and phages. This phase seems to be connected with the existence of biological inertia in the synthesis of phage and bacterial proteins. Proceeding from the comparison with experiments on E. coli and the corresponding phage, the numerical values of the constants of the model were determined by one of the optimization methods. The comparison of theoretical calculations with the results of experimental studies showed that this mathematical model correctly described the dynamics of phagolysis both in qualitative and quantitative aspects.
D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000096:biosynthesis; D001435:Bacteriophages / Q000502:physiology*; D003090:Coliphages / Q000502:physiology; D003201:Computers; D012321:DNA-Directed RNA Polymerases / Q000096:biosynthesis; D004926:Escherichia coli / Q000502:physiology; D008242:Lysogeny; D008433:Mathematics; D008954:Models, Biological; D012329:RNA, Bacterial / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism
D001426:Bacterial Proteins; D012329:RNA, Bacterial; D012321:DNA-Directed RNA Polymerases
Teoretiko-eksperimental'noe issledovanie protsessa fagolizisa.