Effects of interferon on the cAMP-adenylate cyclase system of human, mouse, and bovine thyroid tissue.
This report studied the action of interferon on the thyroidal adenylate cyclase-cAMP system. It was found that human interferon did not increase cAMP levels in human or bovine thyroid slices during a 60-min incubation. Mouse interferon also had no effect on cAMP levels in mouse thyroidal lobes over the 60-min incubation, nor did it increase adenylate cyclase activity in mouse homogenates.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D013961:Thyroid Gland / Q000032:analysis / Q000187:drug effects*
D007372:Interferons; D000242:Cyclic AMP; D000262:Adenylyl Cyclases