Accelerated appearance of an ascitic tumour after long-term application of interferon to NZB/W mice.
In two similarly designed experiments female NZB/W mice treated with mouse L-cell interferon developed an ascitic tumour when the treatment was begun at 3.5 months of age. But no tumour appeared within a 6 months' observation period when 6 months old mice were used. A transient rise of anti-DNA antibodies preceded the tumour appearance in mice. The ascitic tumour was sensitive to antimetabolites and insensitive, or marginally sensitive, to alkylating agents or interferon. The tumour cells were adapted to growth in suspension in vitro. They caused tumour growth in various inbred and random-bred mouse lines. Attempts to transfer the tumour to Swiss mice with cell free preparations were unsuccessful.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001202:Ascitic Fluid; D002455:Cell Division; D002460:Cell Line; D006224:Cricetinae; D005260:Female; D007372:Interferons / Q000009:adverse effects* / Q000096:biosynthesis / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014771:Virion / Q000648:ultrastructure
D000974:Antibodies, Antinuclear; D000970:Antineoplastic Agents; D007372:Interferons