Inhibition of cell motility by interferon.
Interferon derived from human leukocytes, human fibroblasts, and mouse fibroblasts was found to inhibit the motility of cultured cells. It inhibits the tumor-induced motility of capillary endothelial cells as well as the spontaneous migration of other cell types. The ability of a given preparation of interferon to inhibit the motility of a given cell type is proportional to its antiviral activity in that particular cell type. Antiserum to human leukocyte interferon neutralizes both the motility-inhibitory activity and the antiviral activity of this preparation.
D000818:Animals; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002196:Capillaries / Q000166:cytology; D002417:Cattle; D002465:Cell Movement; D002478:Cells, Cultured / Q000502:physiology; D004727:Endothelium / Q000166:cytology; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007962:Leukocytes / Q000502:physiology; D051379:Mice; D009369:Neoplasms / Q000473:pathology
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D007372:Interferons