Some anti-inflammatory activities of copper complexes of amino acids.
Whereas the two isomers of histidine equally enhanced the dextran and Con A anaphylactoid reactions in rats, their copper complexes were potent inhibitors of these reactions. On the other hand, the two isomers of cystine and their copper complexes inhibited the oedema reactions in rat paws induced by dextran, carrageenan and concanavalin A.
D000596:Amino Acids; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D002351:Carrageenan / Q000037:antagonists & inhibitors; D002570:Ceruloplasmin / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D003300:Copper / Q000097:blood / Q000494:pharmacology*; D003553:Cystine / Q000494:pharmacology; D003911:Dextrans / Q000037:antagonists & inhibitors; D006636:Histamine Release / Q000187:drug effects; D006639:Histidine / Q000494:pharmacology; D007536:Isomerism; D051381:Rats; D014364:Tryptophan / Q000494:pharmacology
D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D003911:Dextrans; D003208:Concanavalin A; D003553:Cystine; D006639:Histidine; D003300:Copper; D014364:Tryptophan; D002351:Carrageenan; D002570:Ceruloplasmin