[Use of the probenecid test for the diagnosis and treatment of Parkinsonism. Review of the literature and personal experience (author's transl)].
After describing the clinical picture of Parkinsonism, other Parkinson and depressive syndromes, the authors clarify ascending dopaminergic and serotoninergic pathways in the central nervous system as well as current knowledge on the nigro-striatal pathway. They also underline the interest of the probenecid test in the diagnosis of Parkinsonsism with or without depression. Neurochemical criteria of dopa-sensititivy and dopa-resistance are proposed as well as criteria aimed at serotoninergic therapy. Finally, the use of this neurochemical test in treatment and follow up is illustrated by a clinical case report.
D000368:Aged; D001921:Brain / Q000378:metabolism / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology; D010302:Parkinson Disease, Secondary / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D011339:Probenecid; D012701:Serotonin / Q000378:metabolism
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D011339:Probenecid; D004298:Dopamine; D006719:Homovanillic Acid
Apports du test au probénécide au diagnostic et à la thérapeutique des parkinsoniens. Revue de la littérature et études personnelles.