Helper cells active in the generation of cytotoxicity to a syngeneic tumor.
We have examined a population of thymic lymphocytes that augment the generation in vitro of specific cytotoxic T cells against P815.X2, a syngeneic tumor in DBA/2 mice. These helper cells are evident in the thymus of DBA/2 mice 5 to 7 days after subcutaneous injection of live P815 cells. They are Thy-1 positive, resistant to gamma radiation, antigen specific, and appear to exert their influence most effectively when added at the beginning of the culture.
D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D005260:Female; D007939:Leukemia L1210 / Q000276:immunology*; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000939:Epitopes