Axonal transport of glycoproteins in regenerating olfactory nerve: enhanced glycopeptide concanavalin A-binding.
The size and concanavalin A-binding characteristics of glycopeptides derived from axonally transported glycoproteins were studied in regenerating garfish olfactory nerve. A regeneration related increase was observed in the proportion of total glycopeptide radioactivity associated with the lower molecular weight, dialyzable fraction. There was also a 3-5 fold increase in the axonal transport of low molecular weight concanavalin. A-binding glycopeptides in regenerating nerve. These results suggest a shift to an enhanced synthesis and axonal transport of glycoproteins containing low molecular weight, concanavalin A-binding carbohydrate chains in regenerating nerve.
D000818:Animals; D001370:Axonal Transport; D003208:Concanavalin A; D005399:Fishes; D006020:Glycopeptides / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D009416:Nerve Regeneration; D009832:Olfactory Nerve / Q000502:physiology*; D011485:Protein Binding
D006020:Glycopeptides; D006023:Glycoproteins; D003208:Concanavalin A