title: Developmental changes in the presence of specific chicken fetal-leukemic antigen determinants in the chicken, Japanese quail, and the interspecific hybrid.
abstract: The pattern and timing of expression of chicken fetal-leukemic antigen (CFA) on peripheral red blood cells (RBCs) is reported for specific periods of postembryonic development in chickens, Japanese quail, and quail-chicken hybrids. Individual CFA determinants were lost from the peripheral RBCs of chickens and hybrids at specific times of development. The sequential pattern of phasing in these sources suggests that at least some of the CFA determinants may be expressed independently on the cell surface. In addition, the time of phasing for each determinant may represent a developmentally-controlled change in the internal or external environment of the differentiating erythrocyte. In contrast, three CFA determinants appeared to be lost simultaneously, or over a short period of time, from the RBCs of Japanese quail. This phasing event appears to occur approximately one week prior to the onset of egg production. In the interspecific hybrid, the same three CFA determinants appeared to be independent with regard to the periods in which they were expressed on peripheral RBCs.
mesh_terms: D000818:Animals; D000941:Antigens / Q000502:physiology; D002645:Chickens / Q000276:immunology*; D003370:Coturnix / Q000276:immunology*; D000939:Epitopes; D007962:Leukocytes / Q000276:immunology
chemical_list: D000941:Antigens; D000939:Epitopes