The mechanism of ketotifen-induced histamine release from human peripheral leucocytes.
Ketotifen-induced histamine release from human leucocytes is independent of extracellular calcium and does not require metabolic energy. Furthermore, histamine release is accompanied by a loss of cellular cytoplasmic contents. This suggests that the mechanism of ketotifen-induced histamine release at high concentrations is non-specific and is similar to that of clemastine, a typical H1 antagonist.
D002118:Calcium / Q000378:metabolism; D002974:Clemastine / Q000494:pharmacology; D003593:Cytoplasm / Q000378:metabolism; D004306:Dose-Response Relationship, Immunologic; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007665:Ketotifen / Q000494:pharmacology*; D007962:Leukocytes / Q000276:immunology*
D002974:Clemastine; D002118:Calcium; D007665:Ketotifen