title: [Influence of S-methylmethionine on the metabolism of nucleic acids in Escherichia coli].
abstract: The influence of S-methylmethionine (SMM) on metabolism of nucleic acids in E. coli MRE-600 has been studied. The influence of SMM was compared with that of methionine. Addition of SMM to the medium at the concentration of 2.7 . 10(-5) M increased the incorporation of 5-methyl-3H-thymidine into DNA by about 20% and the incorporation of 2-14C-uridine into the total RNA of the cells by about 47%. The electrophoretic separation of RNA in polyacrylamide gels showed that SMM stimulated the incorporation of the label into 4 S, 5 S, 16 S and 23 S RNA with different intensity. The highest stimulation of the label incorporation has been observed in 16 S RNA.
mesh_terms: D004269:DNA, Bacterial / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D012329:RNA, Bacterial / Q000096:biosynthesis*; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism; D014814:Vitamin U / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D004269:DNA, Bacterial; D012329:RNA, Bacterial; D014815:Vitamins; D014814:Vitamin U; D013936:Thymidine; D014529:Uridine
vernacular_title: Vliianie S-metilmetionine na metabolizm nukleinovykh kislot y E. coli.