Interferon enhances the amount of membrane-bound beta2-microglobulin and its release from human Burkitt cells.
Human leukocytes interferon (HuIFN-A) increased the amount of beta2-microglobulin on the surface of human Burkitt lymphoma cells (Ramos) and also increased the amount released into the culture medium. The effect was observed 1 h after addition of IFN. These results suggest that the increase in beta2-microglobulin on the cell surface of IFN-treated cells is not due to a decreased shedding of antigen from the cell surface, nor an "unmasking" of surface antigen, but rather to an increased synthesis of antigen.
D001609:Beta-Globulins / Q000378:metabolism*; D002051:Burkitt Lymphoma / Q000276:immunology / Q000378:metabolism*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007700:Kinetics; D008565:Membrane Proteins; D001613:beta 2-Microglobulin / Q000276:immunology / Q000378:metabolism*
D001609:Beta-Globulins; D003470:Culture Media; D008565:Membrane Proteins; D001613:beta 2-Microglobulin; D007372:Interferons