title: Antigen-specific T-cell factors.
abstract: Antigen-specific T-cell factors are mediator molecules which are produced by helper and suppressor T cells and which can perform the function of those cells in an antigen-specific manner. They probably play an important part in immunoregulation. The major histocompatibility complex has a controlling influence on their structure and activity, while their antigen-recognition properties may be conferred by immunoglobulin V regions. Interest in the factors derives from three related areas of research, namely (i) the problem of T-cell recognition of antigen; (ii) the mechanisms of cellular interactions in antibody production and cell-mediated immunity; and (iii) the genetic control of immune responses. This review discusses the literature up to June 1980 on their production, structure, genetic restriction and mechanism of action.
mesh_terms: D000818:Animals; D002460:Cell Line; D000939:Epitopes / Q000032:analysis / Q000235:genetics; D005802:Genes, MHC Class II; D006801:Humans; D006822:Hybrid Cells; D007118:Immunoassay / Q000379:methods; D007135:Immunoglobulin Variable Region / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D008957:Models, Genetic; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000939:Epitopes; D007135:Immunoglobulin Variable Region