[Effect of interferon on the inhibition of tumor cell growth by human peripheral leukocytes].
Human leukocyte interferon (HL-IF) enhanced the growth inhibition of tumor cells by the human peripheral leukocytes. There was a dose relation between the enhancement of the growth inhibition of tumor cells and the antiviral activity of interferon. When the ratio of lymphocyte to tumor cell was 10:1 or 50:1, it was recognized that HL-IF enhanced the growth inhibition of tumor cells by lymphocyte. The heterologous IFs--mouse and rabbit IFs--or heat-inactivated or trypsinized IF did not enhance the growth inhibition of tumor cells by lymphocytes. RNase treatment did not reduce the antiviral activity and the growth inhibition.
D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007372:Interferons / Q000302:isolation & purification / Q000494:pharmacology*; D007962:Leukocytes / Q000502:physiology*; D008214:Lymphocytes / Q000502:physiology*; D010222:Parainfluenza Virus 1, Human
D007372:Interferons
Effet de l'interféron sur l'inhibition de la croissance des cellules malignes par les leucocytes périphériques humains.