Peptides influence retinal ganglion cells.
Neurotensin, substance P and (D-Ala2, Met5)-enkephalinamide were iontophoresed onto ganglion cells of the amphibian retina. Substance P and neurotensin were found to be excitatory while (D-Ala2, Met5)-enkephalinamide suppressed all types of ganglion cells. These findings are consistent with a functional role for peptides in the vertebrate retina.
D000663:Amphibians; D000818:Animals; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives*; D004745:Enkephalins / Q000494:pharmacology; D007478:Iontophoresis; D009474:Neurons / Q000187:drug effects*; D009496:Neurotensin / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D010775:Photic Stimulation; D012160:Retina / Q000166:cytology*; D013373:Substance P / Q000494:pharmacology
D004745:Enkephalins; D010446:Peptide Fragments; D010455:Peptides; D013373:Substance P; D009496:Neurotensin; C032682:substance P (4-11); D004744:Enkephalin, Methionine; C022118:enkephalinamide-Met, Ala(2)-