title: Acute leukemia following combination chemotherapy for cancer of the lung.
abstract: A 64-year-old male with recurrent metastatic squamous cell carcinoma was successfully treated with intensive combination chemotherapy. His complete remission was maintained with a nitrosourea, nitrogen mustard and methotrexate for 3 years. While in remission the patient developed acute leukemia. It appears that this secondary malignancy was due to his prolonged chemotherapy.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001761:Bleomycin / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D004317:Doxorubicin / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008130:Lomustine / Q000009:adverse effects; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D014750:Vincristine / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D001761:Bleomycin; D008466:Mechlorethamine; D014750:Vincristine; D008130:Lomustine; D004317:Doxorubicin; D008727:Methotrexate