title: [Non-allergic drug exanthemas].
abstract: Drug reactions similar to allergic reactions according to the differentiation by Coombs and Gell--type I to type V--can be triggered by drugs without the interaction of antibodies and lymphocytes. The immediate hypersensitivity reaction (type I) is imitated in three ways: 1. Histamine release from mast cells or basophiles by drugs without regines (IgE, IgG4), 2. complement activation by a drug via the classic or alternative pathway without reaction with an antibody. 2. intolerance reaction, that means a chronic urticaria triggered by an inhibitor of the prostaglandin synthesis (Aspirin, other analgesics, food additives and dyes). In contrast to the above reactions, non-immune mechanisms mimicking type II to type V reactions are of inferior clinical importance.
mesh_terms: D003167:Complement Activation / Q000187:drug effects*; D003875:Drug Eruptions / Q000503:physiopathology*; D004361:Drug Tolerance; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D011448:Prostaglandin Antagonists; D014581:Urticaria / Q000503:physiopathology
chemical_list: D011448:Prostaglandin Antagonists
vernacular_title: Nicht-allergische Arzneimittel-Exantheme an der Haut.