[Fidelity of a polymerization reaction according to the proximity to equilibrium].
Pyrophosphorolysis, the reverse reaction of nucleotide polymerisation during replication or transcription must influence error-rates. Calculations suggest, for a wide range of reaction mechanisms, a linear dependency between pyrophosphate concentration and the ratio correct/incorrect substrate incorporation. Errors in A.T -rich regions should be particularly sensitive to changes in pyrophosphate concentration.
D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication; D011756:Diphosphates; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D012313:RNA / Q000096:biosynthesis*; D012265:Ribonucleotides / Q000378:metabolism; D014158:Transcription, Genetic
D011756:Diphosphates; D012265:Ribonucleotides; D012313:RNA; D004247:DNA
Fidélité d'une réaction de polymérisation selon la proximité de l'équilibre.