Prazosin lowers plasma triglyceride concentration in rats: a preliminary report.
Prazosin was administered by intraperitoneal injection (0.3 or 3.0 mg/kg) to normal chow-fed male rats for 14 days. Mean +/- SEM plasma triglyceride levels were lower (p less than 0.001) in the prazosin-treated rats (74 +/- 12 mg/dl and 72 +/- 9 mg/dl) than in saline-injected control rats (115 +/- 11 mg/dl). This effect was associated with commensurate reductions in very low density lipoprotein-triglyceride secretion in prazosin-treated rats. No changes were noted in either plasma total or high density lipoprotein cholesterol concentrations. In addition, prazosin was capable of reducing by approximately 50% the elevation in plasma triglyceride concentration produced by a high glucose diet in control rats. The mechanism of the observed effect of prazosin on very low density lipoprotein metabolism in the rat remains to be defined.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D008075:Lipoproteins, HDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D011799:Quinazolines; D014280:Triglycerides; D002784:Cholesterol; D011224:Prazosin