Demonstration of nitrogen coordination in metal--bleomycin complexes by electron spin--echo envelope spectroscopy.
We have studied the Cu(II), Co(II), and Fe(III) complexes of the antineoplastic drug bleomycin by using electron spin--echo envelope spectroscopy. For all three complexes, nitrogen coordination of the metal ions is demonstrated. For the Cu(II)-- and Co(II)--drug complexes, we have been able to identify imidazole as a metal ligand.
D001761:Bleomycin / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D004578:Electron Spin Resonance Spectroscopy; D007093:Imidazoles; D009584:Nitrogen
D007093:Imidazoles; C030187:cobalt bleomycin; C023502:copper bleomycin; C023503:iron bleomycin; D001761:Bleomycin; D009584:Nitrogen