title: I-N: a newly described H-2 I subregion between K and I-A.
abstract: Strong, primary mixed leukocyte culture-proliferative responses in certain K region-incompatible strain combinations led us to consider whether an I region-like locus might exist between K and I-A. Results obtained with an (A. TL X B10.D2)F1 anti-B10.BR serum provided serological evidence for a new locus; B10.T(6R)-absorbed serum retained reactivity on AQR lymphocytes. This finding demonstrates an antigen, Ia.W41, encoded by a locus, Ia-7, within a new I subregion, I-N.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D002874:Chromosome Mapping; D000939:Epitopes; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000939:Epitopes; D006183:H-2 Antigens