Enhancement of Fc gamma receptor expression in interferon-treated mice.
Treatment of C3H mice with partially purified or highly purified virus-induced interferon resulted in a marked increase in the expression of Fcgamma receptors (Fcgamma R) on splenic lymphocytes, mesenteric lymph node cells and thymocytes from cortisone-treated mice. An increase on Fcgamma R on splenic lymphocytes was seen as early as 5 h and lasted at least 72 h after a single injection of interferon. We suggest that enhancement of Fcgamma R is one of the mechanisms by which interferon exerts some immunostimulating effects in vivo.
D000818:Animals; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism; D007372:Interferons / Q000494:pharmacology*; D007457:Iodine Radioisotopes; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology*; D008819:Mice, Nude / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D011961:Receptors, Fc; D007372:Interferons