title: In vitro and in vivo effects of ditazol on human platelets malonylaldehyde (MDA) production.
abstract: Ditazol (4,5-diphenyl-2 bis-hydroxyethylaminoxazol) was tested with regard to its effect in vivo and in vitro on platelet malonyladehyde (MDA) production which seems to be a good marker of prostaglandins metabolism. The drug is a powerful inhibitor of platelet MDA Production induced by thrombin in vitro and this action seems to be due to a "competitive" type effect. "In vivo" experiments showed a significant inhibitory effect on platelet MDA production 4--6 hours after administration of the drug, with return to basal levels within 24 hours.
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008314:Malonates / Q000378:metabolism*; D008315:Malondialdehyde / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008875:Middle Aged; D010080:Oxazoles / Q000494:pharmacology*; D013917:Thrombin / Q000494:pharmacology
chemical_list: D008314:Malonates; D010080:Oxazoles; D008315:Malondialdehyde; D013917:Thrombin