The effect of dextran 70 on the structure of plasma-derived fibrin gels.
Measurements of fiber mass-length ratios and fibrin gel elastic modulus as a function of dextran 70 concentration are reported for fibrin gels derived from human plasma. Dextran 70 at 0.1 mg/ml produces a 50% reduction in the storage modulus of fibrin gels obtained from human plasma diluted 1:10 with saline. Since the fibrin fiber diameter increases as only a weak function of the dextran 70 concentration, the lower elastic modulus most likely results from a reduction in network branch points. Aprotinin is also shown to modulate the dextran effect.
D007611:Aprotinin / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology*; D004548:Elasticity; D005337:Fibrin / Q000032:analysis*; D006801:Humans; D007700:Kinetics; D009391:Nephelometry and Turbidimetry
D003911:Dextrans; D005337:Fibrin; D007611:Aprotinin