Sodium-dependent interaction of benzamides with dopamine receptors in rat and dog anterior pituitary glands.
Sulpiride and other benzamides' displacement of [3H]-spiroperidol binding to rat and dog anterior pituitary dopaminergic receptors was found to be selectively sodium dependent, while typical neuroleptic activity was not influenced by NaCl. These results indicate the existence in the anterior pituitary of a subpopulation of dopaminergic receptors with which benzamides interact.
D000818:Animals; D001549:Benzamides / Q000378:metabolism*; D002069:Butaclamol / Q000378:metabolism; D004285:Dogs; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology*; D013134:Spiperone / Q000378:metabolism; D013469:Sulpiride / Q000378:metabolism; D013764:Tetrahydronaphthalenes / Q000378:metabolism
D001549:Benzamides; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; D012965:Sodium Chloride; D013134:Spiperone; C011639:ADTN; D013469:Sulpiride; D002069:Butaclamol