Immunological cross-reactivity in the absence of DNA homology between Pseudomonas toxin A and diphtheria toxin.
The immunodominant determinant of Pseudomonas toxin A was shown to cross-react with a normally inaccessible determinant in fragment A of diphtheria toxin. Trypsin-treated diphtheria toxin and fragment A of diphtheria toxin inhibited binding of toxin A antibody to whole toxin A, whereas whole diphtheria toxin did not inhibit this reaction. However, even at the lowest stringency no hybridization was detected between diphtheria tox probe and Pseudomonas aeruginosa DNA.
D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D001483:Base Sequence; D003429:Cross Reactions; D004269:DNA, Bacterial; D004167:Diphtheria Toxin / Q000235:genetics / Q000276:immunology*; D000939:Epitopes; D005098:Exotoxins / Q000235:genetics / Q000276:immunology*; D009693:Nucleic Acid Hybridization; D011550:Pseudomonas aeruginosa / Q000235:genetics; D011863:Radioimmunoassay; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D004269:DNA, Bacterial; D004167:Diphtheria Toxin; D000939:Epitopes; D005098:Exotoxins; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A