[Mechanism of silybin action, IV. Structure-action relationship (author's transl)].
In order to find out those structural elements of the flavonolignane silybin which are essential for its stimulatory effect on RNA synthesis, a series of flavonoids etc. has been tested for efficiency. Isolated liver cell nuclei in vitro and hepatocyte cultures have been used to follow RNA synthesis. Only a few compounds show effects similar to those of silybin. Possible structural parameters essential for stimulation are discussed.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012838:Silymarin / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D005419:Flavonoids; D012838:Silymarin; D012313:RNA
Untersuchungen zum Wirkungsmechanismus von Silybin IV. Struktur-Wirkungsbeziehungen.