Pharmacokinetics of subcutaneously administered human, porcine and bovine neutral soluble insulin to normal man.
Highly purified neutral soluble human, porcine and bovine insulin (0.075 U/kg body weight) were administered randomly by subcutaneous injection to six normal men. Somatostatin by continuous intravenous infusion (100 micrograms/h) was used to suppress endogenous insulin secretion. The effects of the three species of insulins on plasma glucose, immunoreactive insulin (IRI), C-peptide and intermediary metabolite concentrations were essentially similar. The onset of hypoglycaemic action of bovine insulin was delayed compared to human and porcine insulin due possibly to a lower receptor binding of the bovine insulin. No local or systemic adverse reactions to the insulins were observed.
D020155:3-Hydroxybutyric Acid; D000328:Adult; D000409:Alanine / Q000097:blood; D000818:Animals; D002096:C-Peptide / Q000097:blood; D002417:Cattle; D005990:Glycerol / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D013004:Somatostatin; D013552:Swine
D002096:C-Peptide; D006885:Hydroxybutyrates; D007328:Insulin; D007773:Lactates; D019344:Lactic Acid; D013004:Somatostatin; D000409:Alanine; D005990:Glycerol; D020155:3-Hydroxybutyric Acid