Stilboestrol toxicity in a dog.
A case of stilboestrol toxicity is described in a dog which was treated for prostatic hyperplasia with stilboestrol dipropionate (10 mg) daily for 5 days. An initial anaemia and thrombocytopaenia of 19,500/microliters was recorded on day 11, and a severe leukocytosis of 125,300/microliters on day 15 was followed by a precipitous drop to 8,400/microliters on day 21. The dog received antibiotic treatment for concurrent peritonitis and prostatitis/cystitis between days 7 and 15. The dog died on day 41 with marrow aplasia.
D000741:Anemia, Aplastic / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D004054:Diethylstilbestrol / Q000506:poisoning* / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D008297:Male; D011470:Prostatic Hyperplasia / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*
D004054:Diethylstilbestrol