["Low-dose heparin" and other methods to prevent thrombo-embolism in gynaecological surgery (author's transl)].
The effectiveness of low-dose heparin has been compared with other methods of thrombo-embolism prophylaxis, on the basis of 892 gynaecological operations. No case of acute venous thrombosis or lethal pulmonary embolism was established in the Infukoll-M-40 group. No effective prophylaxis against thrombo-embolism was obtainable from acetylsalicylic acid (Micristin). More postoperative bleeding was recorded from the low-dose heparin group. Two far-reaching thromboses and three cases of lethal pulmonary embolism occurred in the wake of low-dose heparin prophylaxis. The most favourable effect, in terms of preventing postoperative leg thrombosis and pulmonary embolism, was recorded from low-molecular dextran (Infukoll M 40). Anaphylactoid reactions, such as bronchospasm, flush, urticaria, and hypotension, were not observed. A therapy standard for gynaecological operations is recommended, with reference being made to the authors' own findings.
D001241:Aspirin / Q000627:therapeutic use; D003911:Dextrans / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004928:Escin / Q000627:therapeutic use; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D013923:Thromboembolism / Q000517:prevention & control*
D003911:Dextrans; D004928:Escin; D006493:Heparin; D001241:Aspirin
"Low-dose-Heparin" und andere Verfahren zur Thromboembolic-Prophylaxe bei gynäkologischen Operationen.