Effect of substance P and its natural analogues on gastric emptying of the conscious rat.
1 Substance P and its natural analogues were tested for their effect on gastric emptying in the rat. 2 Substance P and kassinin were virtually inactive even at the maximum dose tests. 3 The other tachykinins significantly delayed gastric emptying their effect being quite remarkable with 100 micrograms/kg. The lowest doses (30 microgram/kg) caused a slight and non-significant increase in emptying rate. 4 The effect on gastric emptying was most probably correlated with a spasmogenic effect on the gastroduodenal junction, as pointed out in previous work.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005746:Gastric Emptying / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology*
D013373:Substance P