title: Chemotherapy of disseminated seminoma.
abstract: Nineteen patients with disseminated seminoma were treated with platinum + vinblastine + bleomycin +/- Adriamycin. All patients have been followed for at least 1 year. Nine patients had elevated HCG and two also had elevated AFP. Twelve of 19 patients (63%) achieved a complete remission, with a median duration of 18 months, and none of these patients have relapsed. Four of these patients have been in a continuous complete remission for over 2 years. The results of chemotherapy in metastatic seminoma are comparable to those achieved in nonseminomatous germ-cell tumors, and similar treatment strategies should be employed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage; D006063:Chorionic Gonadotropin / Q000097:blood; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004407:Dysgerminoma / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013736:Testicular Neoplasms / Q000097:blood / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000970:Antineoplastic Agents; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D001761:Bleomycin; D014747:Vinblastine; D004317:Doxorubicin; D002945:Cisplatin