Effect of acyclovir and interferon on human hematopoietic progenitor cells.
Continuous in vitro exposure of human bone marrow cells to acyclovir (approximately 200 microM) or human leukocyte interferon (approximately 250 U/ml) caused 50% inhibition of granulocyte colony-forming cell differentiation. Colonies expressed in the presence of either agent were reduced both in size and number. Erythroid progenitors were more resistant than granulocyte progenitors to the antiproliferative effects of acyclovir. Progenitor cells of patients recovering from cytotoxic chemotherapy were no more sensitive to the effects of acyclovir or interferon than were cells obtained from patients before chemotherapy.
D000212:Acyclovir; D000998:Antiviral Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006147:Guanine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007372:Interferons / Q000009:adverse effects*
D000998:Antiviral Agents; D006147:Guanine; D007372:Interferons; D000212:Acyclovir