Enumeration of immune interferon-producing cells induced by allogeneic stimulation.
We succeeded in enumerating interferon-producing cells induced by allogeneic stimulation, and proved that they were indeed T lymphocytes. The peak level of these cells in spleen was attained on day 5 after immunication, was maintained for about 2 days, and declined thereafter. Titers of interferon produced in vitro by sensitized spleen cells were maximum on day 7. This suggests that the maturation of immune interferon-producing cells follows cell proliferation after antigen stimulation.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D003513:Cycloheximide / Q000494:pharmacology; D007106:Immune Sera; D007372:Interferons / Q000096:biosynthesis*; D007519:Isoantigens / Q000276:immunology*; D007739:L Cells / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D007106:Immune Sera; D007519:Isoantigens; D007372:Interferons; D003513:Cycloheximide