[In vivo induction of antigenic modulation in man by an anti-T cell monoclonal antibody (author's transl)].
The anti-T cell monoclonal antibody OKT3 was administered to renal allograft recipients. A dramatic depletion of peripheral T cells was immediately observed followed, after 2-5 days, by the reappearance of a limited but significant number of or OKT3-4+ or OKT3-8+T cells showing antigenic modulation of the OKT3-defined antigen. These cells recovered the OKT3 receptor after overnight in vitro incubation.
D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D000954:Antigens, Surface / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000939:Epitopes
Induction in vivo chez l'homme du phénomène de modulation antigénique par un anticorps monoclonal anti lymphocytes T.