Dissociation of beta-adrenoceptor-induced effects on amylase secretion and cyclic adenosine 3', 5' monophosphate accumulation.
By using a multi-channel microperifusion system the effects of noradrenaline, the beta1-adrenoceptor agonist prenalterol, and the beta2-selective agonist terbutaline were studied on amylase pig submandibular glands. 2 Noradrenaline caused significant amylase discharge and cyclic AMP accumulation. 3 Prenalterol was as effective as noradrenaline in causing amylase release but did not significantly affect the cyclic AMP content. 4 Terbutaline stimulated cyclic AMP accumulation, but had little effect on amylase secretion. 5 The present study reveals that there is a dissociation of the beta-adrenoceptor-induced amylase release and cyclic AMP formation, and that this dissociation may be due to different beta-adrenoceptor subtypes.
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D009638:Norepinephrine / Q000494:pharmacology; D010306:Parotid Gland / Q000378:metabolism; D011217:Practolol / Q000031:analogs & derivatives / Q000494:pharmacology; D011294:Prenalterol; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism*; D013363:Submandibular Gland / Q000378:metabolism; D013726:Terbutaline / Q000494:pharmacology; D013997:Time Factors
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D000681:Amylases; D011294:Prenalterol; D013726:Terbutaline; D011217:Practolol; D009638:Norepinephrine