[Neuropharmacological drugs effect on functional activity of rat brain].
The influence of some neuropharmacological drugs was studied as applied to RNA synthesis and animal behaviour. The phosphodiesterase, adenyl cyclase and monoaminoxidase activities in glial cells were investigated as well. The glial cells are stated to possess a high activity of phosphodiesterase, adenyl cyclase and monoaminoxidase A. Neuropharmacological drugs, reserpine and transamine produce a different influence of RNA synthesis in vivo, but have no effect in vitro. Transamine and reserpine accelerate the formation of conditioned defensive reflex but they strongly inhibited the reproduction of this reflex.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D014148:Tranexamic Acid
D012313:RNA; D014148:Tranexamic Acid; D012110:Reserpine; D008995:Monoamine Oxidase; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases
Issledovanie vliianiia neprofarmakologicheskikh veshchestv na funktsional'nuiu aktivnost'golovnogo mozga krys.