Influence of increased temperature on the inhibition of rat osteosarcoma cell multiplication "in vitro" by interferon.
Purified rat interferon preparations proved effective in inhibiting cell multiplication in a rat osteosarcoma cell line. A pronounced increase in the inhibitory activity was found with increasing temperature. At 39 degrees C 20 Interferon units/ml appeared to be cytotoxic whereas incubation of cells with 2,000 Interferon units/ml at 35 degrees C resulted in a cytostatic effect.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D006358:Hot Temperature; D007372:Interferons / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012516:Osteosarcoma / Q000188:drug therapy*; D051381:Rats
D007372:Interferons