title: The little-known determinants of virus pathogenicity.
abstract: Of the four cardinal facets of microbial pathogenicity: (1) entry to the host usually by penetrating mucous membranes; (2) multiplication in the host tissues; (3) interference with host defence; and (4) damage to the host; only multiplication (replication) has received much attention in studies of virus pathogenicity. This article points out the gaps in our knowledge of the other three areas emphasising that although some observations have been made on the invasive and pathological processes involved, the viral determinants concerned are mostly unknown.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001424:Bacterial Infections / Q000150:complications; D003588:Cytopathogenic Effect, Viral; D005334:Fever / Q000276:immunology; D006801:Humans; D007372:Interferons / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009092:Mucous Membrane / Q000382:microbiology; D009093:Mucus / Q000276:immunology; D014774:Virulence; D014777:Virus Diseases / Q000150:complications / Q000276:immunology / Q000382:microbiology; D014779:Virus Replication; D014780:Viruses / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D000914:Antibodies, Viral; D007372:Interferons