Myo-inositol action on gerbil intestine: reversal of a diet-induced lipodystrophy and change in microsomal lipase activity.
An intestinal lipodystrophy induced by dietary fat in female Mongolian gerbils (Meriones unguiculatus) was reversed to normal by myo-inositol given in the diet or by injection within 1-4 days. An increase in plasma chylomicron and lipid concentrations was observed before the occurrence of rapid disappearance of accumulated lipids from the intestine. Dietary myo-inositol also caused an increase in triacylglycerol release from everted gut sacs. Thus, myo-inositol might act on the intestine to stimulate the production and secretion of chylomicrons, travelling via the lymphatic pathway into the bloodstream. The activity of pH 9.0 microsomal lipase (EC 3.1.1.3) of gerbil intestine was decreased due to myo-inositol deficiency. The lowered activity could be restored to high levels by feeding of injecting myo-inositol in vivo. A time-course study during intestinal recovery indicates that the increase in microsomal lipase activity correlated with the rapid lipid removal phase of the intestine, but not the initial increase in plasma chylomicron and triacylglycerol concentrations.
D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects; D005260:Female; D005849:Gerbillinae; D007294:Inositol / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D008049:Lipase / Q000378:metabolism*; D008861:Microsomes / Q000201:enzymology; D014280:Triglycerides / Q000378:metabolism; D008061:Whipple Disease / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism
D004041:Dietary Fats; D014280:Triglycerides; D007294:Inositol; D008049:Lipase