The influence of haloperidol and aminooxyacetic acid on etonitazene, alcohol, diazepam and barbital consumption.
Four groups of rats were given free choice between water and solutions of either 3 micrograms/ml etonitazene, 5% ethanol (v/v), 0.1 mg/ml diazepam or 3 mg/ml barbital for 10-14 days. With the exception of barbital, some rats spontaneously preferred the drug solutions to water. This preference was reduced by addition of 7 micrograms/ml haolperidol. In a forced drug fluid consumption procedure, the daily administration of 15 mg/kg i.p. of the gamma-aminobutyric acid (GABA)-transaminase blocker aminooxyacetic acid (AOAA) led to a reduction of ethanol and diazepam intake, but not of etonitazene and barbital. It is suggested that the diminished consumption of ethanol and diazepam as caused by GABA-T-inhibition may also be mediated by dopamine which seems to act indirectly, via benzodiazepine receptors and GABA neurons.
D000085:Acetates / Q000494:pharmacology*; D000428:Alcohol Drinking; D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D001462:Barbital; D001463:Barbiturates; D001562:Benzimidazoles; D001921:Brain / Q000187:drug effects; D003975:Diazepam; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects; D012646:Self Administration; D019966:Substance-Related Disorders / Q000517:prevention & control*
D000085:Acetates; D001463:Barbiturates; D001562:Benzimidazoles; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D000625:Aminooxyacetic Acid; D001462:Barbital; D006220:Haloperidol; D003975:Diazepam