Beta-thromboglobulin and platelet factor 4 plasma levels during haemodialysis: effect of indobufen.
The effect of a single dose of indobufen (100 mg i.v.) on the release of beta-thromboglobulin and of the platelet factor 4 was investigated during dialysis in 20 uraemic subjects by a within-subjects, single-blind, indobufen versus placebo study. Plasma levels were measured in baseline conditions and 15, 30, 60, 120 and 240 minutes after the beginning of dialysis. Pre-treatment with indobufen clearly inhibited beta-TG and PF 4 output. The difference from placebo was highly significant (p less than 0.01) from the 30-minute control up to the end of dialysis. No changes in platelet count before and after dialysis were observed.
D000328:Adult; D001609:Beta-Globulins / Q000378:metabolism*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D010654:Phenylbutyrates / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010978:Platelet Factor 4 / Q000378:metabolism*; D006435:Renal Dialysis; D013997:Time Factors; D001620:beta-Thromboglobulin / Q000378:metabolism*
D001609:Beta-Globulins; D001779:Blood Coagulation Factors; D007211:Indoles; D054833:Isoindoles; D010654:Phenylbutyrates; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; C020371:indobufen