[Gamma globulin as a prophylactic measure in an outbreak of hepatitis A in an institution for mentally retarded children (author's transl)].
An outbreak of hepatitis A was observed in an institution for mentally handicapped children. Within 2 months 21 cases occurred in 4 out of 7 groups. By means of gamma-globulin administration and measures of general hygiene, the outbreak, although not immediately stopped, was brought under control. The number of overt cases was reduced and further transmission to 3 other groups was prevented. The detection of IgM antibodies to hepatitis A virus proved to be very suitable for diagnostic purposes. Subsequently it turned out that the gamma-globulin used had a very low titre in comparison with other preparations. Recommendations are given to prevent similar outbreaks in the future.
D000917:Antibody Formation; D001317:Austria; D002648:Child; D004196:Disease Outbreaks / Q000517:prevention & control*; D004495:Education of Persons with Intellectual Disabilities; D006506:Hepatitis A / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007326:Institutionalization; D005719:gamma-Globulins / Q000008:administration & dosage*
D007075:Immunoglobulin M; D005719:gamma-Globulins
Gammaglobulinprophylaxe bei einem Hepatitis-A-Ausbruch in einem Heim für geistig behinderte Kinder.