title: The histamine releasing properties of some agents used in textile industry.
abstract: The inflammatory effect of some compounds (polyglycolamines and polyglycolalcohols condensated with various number of ethylene oxide groups) used in textile industry were investigated as to their action on skin vascular permeability in rats and histamine release from rat peritoneal mast cells. The intradermal injection of tested agents caused the inflammatory skin reactions of various intensity depending on time, dose and chemical structure of agent used. It has been also shown that these properties of tested compounds were correlated with their histamine releasing activity and seemed to be dependent on their chemical structure, namely, the number of ethylene oxide groups in molecule. It is suggested that the histamine release induced by tested compounds is of cytotoxic nature since it depends neither on metabolic energy nor on extracellular calcium.
mesh_terms: D000605:Amino Alcohols / Q000633:toxicity; D000818:Animals; D002199:Capillary Permeability; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D011092:Polyethylene Glycols / Q000633:toxicity*; D051381:Rats; D012867:Skin / Q000187:drug effects; D013783:Textile Industry
chemical_list: D000605:Amino Alcohols; D011092:Polyethylene Glycols