Phagocytosis of outer segments by cultured rat pigment epithelium. Reduction by cyclic AMP and phosphodiesterase inhibitors.
Phagocytosis of isolated outer segments by cultured rat pigment epithelium was decreased by cyclic 3',5'adenosine monophosphate (cyclic AMP), dibutyryl cyclic AMP, and three phosphodiesterase inhibitors (isobutylmethylxanthine, papaverine, and SQ 65442). Cyclic GMP and its dibutyryl derivative had little effect on phagocytosis. Phagocytosis was moderately reduced by several other purine nucleotides and nucleosides and substantially reduced by adenine.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D066298:In Vitro Techniques; D009539:Nicotinic Acids / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010857:Pigment Epithelium of Eye / Q000187:drug effects*; D051381:Rats; D012374:Rod Cell Outer Segment / Q000187:drug effects
D009539:Nicotinic Acids; D010726:Phosphodiesterase Inhibitors; C027166:SQ 65442; D003994:Bucladesine; D010208:Papaverine; D000242:Cyclic AMP; D015056:1-Methyl-3-isobutylxanthine