Synthesis of ent-17-(prop-1-ynyl-17 beta-hydroxy-11 beta-(4-(N,N-dimethylamino)-phenyl)-4,9-estradien-3-one, the antipode of RU-38 486.
The title compound was synthesized and tested for its biological activities. It showed neither antiprogesterone nor antiglucocorticoid properties.
D000019:Abortifacient Agents / Q000138:chemical synthesis*; D000021:Abortifacient Agents, Steroidal / Q000138:chemical synthesis*; D000818:Animals; D001755:Blastocyst / Q000187:drug effects; D004963:Estrenes; D005260:Female; D005938:Glucocorticoids / Q000037:antagonists & inhibitors; D007202:Indicators and Reagents; D008114:Liver Neoplasms, Experimental / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D015735:Mifepristone; D009904:Optical Rotation; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014444:Tyrosine Transaminase / Q000378:metabolism
D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D004963:Estrenes; D005938:Glucocorticoids; D007202:Indicators and Reagents; D015735:Mifepristone; D014444:Tyrosine Transaminase