Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver.
The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats to enhance the incidence of gamma-glutamyltranspeptidase (GGTase)-positive foci was determined. In rats that received either DENA followed by a basal agar diet or hexachlorobenzene or lindane without prior administration of DENA, the incidence of GGTase-positive foci was negligible. When hexachlorobenzene or lindane were administered in the diet to rats that previously received a 2/3 partial hepatectomy prior to the DENA. The results suggest that hepatocarcinogenicity of hexachlorobenzene and lindane results from tumor promotion.
D000818:Animals; D002722:Chlorobenzenes / Q000494:pharmacology*; D004032:Diet; D004052:Diethylnitrosamine; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006498:Hepatectomy; D006581:Hexachlorobenzene / Q000494:pharmacology*; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D002722:Chlorobenzenes; D004052:Diethylnitrosamine; D006581:Hexachlorobenzene; D001556:Hexachlorocyclohexane; D005723:gamma-Glutamyltransferase