Calculation and registration of the same motor unit action potential.
In order to increase insight into the electrical phenomena of active motor units, a computer simulation model has been developed. With this model motor unit action potentials (MUAPs) have been calculated. The model has been based on the superposition of the muscle fibre potentials of the fibres of one motor unit. For verification, calculated MUAPs have been compared with the matching recorded MUAPs. During experiments one motor unit was stimulated and the MUAP of this unit was measured with intramuscular wire electrodes. After the experiments the positions of the activated fibres of this unit and of the electrodes were determined by means of histochemical techniques. Other parameters were derived from other experiments or the literature. Using the obtained set of parameters in the model MUAPs were calculated. These MUAPs were compared with the measured MUAPs. From this comparison it has been concluded that the model predicts the MUAP to an appreciable degree. The results clearly show the dominating effect of muscle fibres in close vicinity of the electrode and the important effect of the activation moment of those fibres on the shape of the MUAP.
D000200:Action Potentials; D000818:Animals; D004553:Electric Conductivity; D004576:Electromyography; D008433:Mathematics; D009045:Motor Endplate / Q000033:anatomy & histology; D009046:Motor Neurons / Q000502:physiology; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology*; D009431:Neural Conduction; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors