title: The effect of sulphydryl block on the binding of H1-antagonists to the muscarinic receptor.
abstract: The treatment of brain muscarinic receptors by p-chlormercuribenzoate is known to change structure-activity relationships for antagonists. The changes in binding affinity of H1-antagonists for this receptor have been measured; the changes are similar to those for intrinsic muscarinic antagonists.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002729:Chloromercuribenzoates / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000378:metabolism*; D066298:In Vitro Techniques; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000378:metabolism; D013439:Sulfhydryl Reagents / Q000494:pharmacology*; D020245:p-Chloromercuribenzoic Acid
chemical_list: D002729:Chloromercuribenzoates; D006634:Histamine H1 Antagonists; D011976:Receptors, Muscarinic; D013439:Sulfhydryl Reagents; D020245:p-Chloromercuribenzoic Acid