[Antibiotics as inhibitors of the prokaryotic protein biosynthesis: action and resistance mechanisms (author's transl)].
Most of the known antibiotics interfere with the translational apparatus due to the extraordinary complexity of the translational organelle, the ribosome. After a short survey on structure and function of the ribosome the action of some antibiotics is explained and integrated in an extended scheme of ribosomal functions. Furthermore, various resistance strategies of the translational apparatus against the antibiotics are described.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D001666:Binding Sites, Antibody; D000939:Epitopes; D004926:Escherichia coli / Q000648:ultrastructure; D005672:Fusidic Acid / Q000378:metabolism; D010445:Peptide Elongation Factors / Q000378:metabolism; D011691:Puromycin / Q000378:metabolism; D011728:Pyridones / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D000939:Epitopes; D010445:Peptide Elongation Factors; D011728:Pyridones; D012335:RNA, Ribosomal; D011691:Puromycin; D005672:Fusidic Acid; D012343:RNA, Transfer; C008536:mocimycin
Antibiotika als Inhibitoren der bakteriellen Proteinbiosynthese: Wirkungsweise und Resistenzmechanismen.