[Amino liberation in Brown-Norway rats].
When injected intravenously with dextran or O-hydroxyethyl derivatives of rutoside, rat Brown Norway BN/Mai Pfd f exhibit a fall in the blood pressure and an increase of vascular permeability with oedema formation. As the rat is genetically deprived of plasmatic prekallikrein an of kininogens, activation of the kinin system is not necessary neither for mast-cell degranulation nor for amine release.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D003911:Dextrans / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced; D006896:Hydroxyethylrutoside / Q000494:pharmacology; D007022:Hypotension / Q000139:chemically induced; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines; D003911:Dextrans; D006896:Hydroxyethylrutoside
Amino-libération chez le rat Brown-Norway.