Genetic analysis of human salivary alpha-amylase isozymes by isoelectric focusing.
The isozymes of human salivary alpha-amylase have been separated by thin-layer gel isoelectric focusing in a pH 4-8 gradient followed by a starch-iodine zymogram procedure. The normal isozyme pattern (N) consisted of five major isozymes together with a number of minor ones. In addition, seven variant isozyme phenotypes were also observed, which had a combined frequency of 11.7% in a random population of 368 individuals. Analysis of familial data is indicative of the inheritance of autosomal codominant alleles.
D000681:Amylases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007526:Isoelectric Point; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic; D000516:alpha-Amylases / Q000235:genetics*
D007527:Isoenzymes; D000681:Amylases; D000516:alpha-Amylases