Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.
D000818:Animals; D002478:Cells, Cultured; D008114:Liver Neoplasms, Experimental / Q000201:enzymology / Q000378:metabolism; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D010455:Peptides / Q000633:toxicity*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013936:Thymidine / Q000096:biosynthesis
D010455:Peptides; D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D013762:Tetrahydrofolate Dehydrogenase; D013936:Thymidine; D008727:Methotrexate