Effect of gramicidin D on the acidogenic properties of oral streptococci and human dental plaque.
The effect of gramicidin D, Gramicidin S, and carbonylcyanide p-trifluoromethoxyphenyl hydrazone on the glycolysis of various oral streptococci was investigated. Gramicidin D was the most effective and inhibited the glycolysis of all the streptococci studied in the presence of the most common sugars found in man's diet (sucrose, lactose, glucose, and fructose). A concentration of 2.5 X 10(-6) M gramicidin D was sufficient to decrease significantly the rate of glycolysis of human dental plaque in the presence of sucrose. The use of this ionophore as a caries preventive agent is discussed.
D000143:Acids / Q000378:metabolism; D002327:Cariostatic Agents; D003773:Dental Plaque / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects; D006096:Gramicidin / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009055:Mouth / Q000382:microbiology*; D013291:Streptococcus / Q000378:metabolism*; D013295:Streptococcus mutans / Q000378:metabolism; D013298:Streptococcus sanguis / Q000378:metabolism; D013997:Time Factors
D000143:Acids; D002327:Cariostatic Agents; D006096:Gramicidin