Brain 5-hydroxytryptamine metabolism after portocaval anastomosis: relationship with ambulation.
Chronic portocaval anastomosis (PCA) increased tryptophan and 5-hydroxyindoles in rat brain regions. PCA rats ambulated less than sham operated animals but showed positive correlations between ambulation and indices of brain 5-hydroxytryptamine (5-HT) metabolism, i.e., plasma free tryptophan, plasma non-esterified fatty acid, tryptophan in all brain regions, and 5-HT or 5-hydroxyindoleacetic acid in some regions. Results suggest a positive and non-causal association between motor activity and 5-HT metabolism in the PCA rats reflecting parallel responses of both variables to environmental stimulation. This may be superimposed on a normal inverse and causal relationship between motor activity and 5-HT metabolism.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008124:Locomotion; D008297:Male; D011167:Portacaval Shunt, Surgical; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000097:blood
D005230:Fatty Acids, Nonesterified; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan