Elevated beta-thromboglobulin in patients with chronic renal failure: effect of hemodialysis.
Elevated plasma concentrations of beta-thromboglobulin were observed in 25 consecutive patients with chronic renal failure. Further increases in this platelet protein were observed during hemodialysis but not during peritoneal dialysis. The hemodialysis-induced increases were not prevented by either aspirin or dipyridamole, a fact which suggested that release of this protein was not dependent on platelet functional activity. Measurement of beta-thromboglobulin provides a sensitive indicator of platelet disruption during hemodialysis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001609:Beta-Globulins / Q000032:analysis*; D001792:Blood Platelets / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D001620:beta-Thromboglobulin / Q000032:analysis*
D001609:Beta-Globulins; D001620:beta-Thromboglobulin