Enzyme induction in rat liver: the effects of Be2+ in vivo.
Rats given an LD50 dose of Be2+ showed reduced activities of ornithine decarboxylase and tyrosine aminotransferase in liver in response to dexamethasone induction. Control fed animals showed 'superinduction'. Be2+ also inhibited the uptake of [3H]orotic acid into rapidly labelled RNA of ribonucleoprotein particles extracted from liver nuclei in isomolar solutions at pH 8.0. Consistent with inhibition of cytoplasmic protein kinase reported previously (Kaser et al., 1980), the uptake of [32P]Pi into proteins in the ribonucleoprotein particles was also diminished.
D000818:Animals; D001608:Beryllium / Q000494:pharmacology*; D002262:Carboxy-Lyases / Q000096:biosynthesis*; D003907:Dexamethasone / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000201:enzymology*; D008297:Male; D009698:Nucleoproteins / Q000378:metabolism*; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D009963:Orotic Acid / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012261:Ribonucleoproteins / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D009698:Nucleoproteins; D010710:Phosphates; D012261:Ribonucleoproteins; D009963:Orotic Acid; D012313:RNA; D003907:Dexamethasone; D014444:Tyrosine Transaminase; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D001608:Beryllium