Comparison between human IgM and IgG antibodies to dextran, regarding their activities in antibody-dependent cellular cytotoxicity (ADCC).
Human sera containing dextran-reactive antibodies of various immunoglobulin classes were tested for their capacity to induce ADCC against dextran-coated chicken red blood cells (CRBC). It was found that only IgG antibodies were active in ADCC, while IgM antibodies were not, thus providing further evidence that IgM antibodies do not contribute to ADCC even when human antibodies are used.
D000818:Animals; D000906:Antibodies; D000920:Antibody-Dependent Cell Cytotoxicity; D002645:Chickens; D003911:Dextrans / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D011817:Rabbits
D000906:Antibodies; D003911:Dextrans; D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M