Possible risks of general anesthesia in patients with intraventricular conduction disturbances.
In order to assess the risk of complete AV block in patients with intraventricular conduction disturbances who undergo general anesthesia, 20 patients with various conduction defects (7 LBBB, 1 RBBB and 1st degree AV block, 1 incomplete RBBB, 9 RBBB + LAH and 2 RBBB + LPH) were studied by means of His bundle recording and corrected sinus node recovery time (CSNRT) before and after the subministration of thiopental (0.2 g I.V.), succinylcholine (1 mg/kg I.V.), Fluothane (1%) and Ethrane (1.6%). Nineteen patients displayed signs of dizziness or syncope; both the sinus rate and the CSNRT, did not undergo significant variations. A slight and not significant variation of intranodal conduction during sinus rhythm was observed after Fluothane administration (AH was prolonged by 8%). A less evident negative dromotropic action of thiopental and Ethrane was only revealed by atrial pacing. No significant variations were demonstrated in His-ventricular conduction after administration of the various drugs. The maximum average increase (1.5%) of the H-V interval was observed after administration of succinylcholine. Acute AV block distal to the His bundle appeared in three patients after succinylcholine administration.
D000768:Anesthesia, General / Q000009:adverse effects*; D002037:Bundle-Branch Block; D002304:Cardiac Pacing, Artificial; D004594:Electrophysiology; D004737:Enflurane / Q000009:adverse effects; D006221:Halothane / Q000009:adverse effects; D006327:Heart Block; D006801:Humans; D012306:Risk; D013390:Succinylcholine / Q000009:adverse effects; D013874:Thiopental / Q000009:adverse effects
D004737:Enflurane; D013390:Succinylcholine; D013874:Thiopental; D006221:Halothane