Interferon inhibits the redistribution of cell surface components.
Interferon treatment impairs the ability of cells to redistribute cell surface receptors for concanavalin A (Con A). The effect of interferon becomes evident within 3-6 h and is maximal within 36-48 h. Highly purified human fibroblast interferon (> 2 x 10(8) U/mg of protein sp act; concentration; 640 U/ml) caused approximately 85% inhibition of capping of fluorescein-conjugated Con A in interferon-sensitive HeLa-S3 cells at 36 h from the beginning of treatment.
D002462:Cell Membrane / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006367:HeLa Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D011952:Receptors, Concanavalin A / Q000187:drug effects*; D013997:Time Factors
D011952:Receptors, Concanavalin A; D007372:Interferons