ATP as a co-transmitter in rat tail artery.
In rat tail artery the electrical response to nerve stimulation was biphasic, consisting of a fast, transient depolarisation which was resistant to alpha-adrenoceptor antagonists and a slow, prolonged depolarisation which was abolished by them. In the presence of alpha, beta-methylene-adenosine 5'-triphosphate (alpha, beta-methylene-ATP), which abolishes responses mediated via P2-purinoceptors, the fast depolarisation was abolished, whilst the slow depolarisation persisted. We propose that both adenosine 5'-triphosphate (ATP) and noradrenaline (NA) are involved in sympathetic neurotransmission in the rat tail artery.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001158:Arteries / Q000294:innervation / Q000502:physiology*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D011983:Receptors, Purinergic; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D013623:Tail / Q000098:blood supply
D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate; D010646:Phentolamine