title: The genetic and enzymic regulation of the synthesis of the A and B determinants in the ABO blood group system.
abstract: Possible genetic models for the inheritance of the ABO blood groups are discussed in terms of the glycosyltransferase enzymes which complete the synthesis of the A and B determinants. Recent immunologic evidence in support of the allelic status of the ABO genes is reviewed. Results are presented of experiments which demonstrate that the B gene associated alpha-3-D-galactosyltransferase can be used to synthesis blood group A determinants.
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000116:Acetylgalactosamine / Q000494:pharmacology; D000483:Alleles; D000818:Animals; D000939:Epitopes; D005700:Galactosyltransferases / Q000276:immunology / Q000494:pharmacology; D005815:Genetic Code; D005964:Glucosyltransferases / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D017350:N-Acetylgalactosaminyltransferases; D011817:Rabbits
chemical_list: D000017:ABO Blood-Group System; D000939:Epitopes; D005700:Galactosyltransferases; D005964:Glucosyltransferases; D017350:N-Acetylgalactosaminyltransferases; C003742:UDPgalactosamine-galactose acetylgalactosaminyltransferase; D000116:Acetylgalactosamine