Hepatic injury in dermatitis herpetiformis.
Liver function tests were performed in 60 patients with dermatitis herpetiformis. Abnormalities of bilirubin or elevated liver enzyme levels were found in 17% of the patients. 13% had abnormal liver enzymes or elevated bilirubin levels not due to haemolysis. In 8% of patients bilirubin levels were elevated as a result of dapsone-induced haemolysis. The incidence of liver function abnormalities was higher (19%) in those on a normal diet than those on a gluten-free diet (9%). The abnormalities were not associated with the presence of immune complexes, anti-mitochondrial or anti-smooth muscle antibodies.
D003622:Dapsone / Q000627:therapeutic use; D003874:Dermatitis Herpetiformis / Q000150:complications* / Q000628:therapy; D004032:Diet; D005260:Female; D005983:Glutens; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D008111:Liver Function Tests; D008297:Male
D005983:Glutens; D003622:Dapsone