Chromosome analysis in a human hepato-blastoma cell line producing alpha-fetoprotein.
Analysis of the chromosomes of a cloned human hepato-blastoma cell line, HUH-6-clone 5 by Q-, G- and C-banding revealed numerical and structural chromosome aberrations. The modal number of chromosomes was 49. Trisomies #12 and 20 were present in most of the cells, and 8q isochromosome was detected in all of the cells analyzed. High levels of alpha-fetoprotein production by this cell strain were also demonstrated.
D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D002869:Chromosome Aberrations; D002903:Chromosomes, Human, 19-20 / Q000648:ultrastructure; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism; D014314:Trisomy; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins