Actinomycin inhibits gastric mucosal protection by prostacyclin in rats.
The protective effect of prostacyclin on gastric mucosal damage by indomethacin or restraint in rats was inhibited by actinomycin-C. Protection by prostacyclin may therefore require new protein synthesis.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology*; D011464:Epoprostenol / Q000037:antagonists & inhibitors*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D010437:Peptic Ulcer / Q000139:chemically induced; D011448:Prostaglandin Antagonists; D051381:Rats; D012149:Restraint, Physical
D011448:Prostaglandin Antagonists; D003609:Dactinomycin; D011464:Epoprostenol; D007213:Indomethacin