title: Studies on the plasma membrane of normal and psoriatic keratinocytes. 3. Uptake of labelled sugars and their incorporation into glycoconjugates.
abstract: We report the uptake of four labelled sugars by keratinocytes isolated from normal epidermis, psoriatic 'uninvolved' skin and psoriatic lesions. Our findings include the following: (1) The rate of uptake of all sugars by the psoriatic lesion is increased. (2) This abnormally high uptake diminishes dramatically during 22 h incubation in vitro. (3) There is a striking abnormality in the metabolism of fucose by psoriatic keratinocytes; our data suggest an increased rate of incorporation of fucose into glycoconjugates.
mesh_terms: D050260:Carbohydrate Metabolism; D002462:Cell Membrane / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism; D005643:Fucose / Q000378:metabolism; D006017:Glycolipids / Q000096:biosynthesis; D006023:Glycoproteins / Q000096:biosynthesis; D006801:Humans; D066298:In Vitro Techniques; D007633:Keratins; D011509:Proteoglycans / Q000096:biosynthesis; D011565:Psoriasis / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D006017:Glycolipids; D006023:Glycoproteins; D011509:Proteoglycans; D005643:Fucose; D007633:Keratins