Effect of the alpha globulin fraction on the survival time of C3H mice (C3H/Sumice and C3H/VUFB) with a solid Gardner lymphosarcoma.
The effect of the alpha globulin fractions of human serum administered before the inoculum of tumour cells was studied in two sublines of C3H mice (C3H/VUFB and C3H/Sumice) showing a different resistance to a solid Gardner lymphosarcoma. The survival time of animals was shortened in both sublines, but more markedly in C3H/VUFB mice that were more resistant to the tumour. The survival was found to depend on the dose and the immunosuppressive activity of the alpha globulin fractions as revealed in other in vitro and in vivo tests. We believe that the tumour model using C3H/VUFB mice may be used as a further test for determining the activity of alpha globulin fractions.
D000510:Alpha-Globulins / Q000494:pharmacology*; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D005260:Female; D008213:Lymphocyte Activation; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000401:mortality*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology / Q000401:mortality; D012397:Rosette Formation; D012709:Serum Albumin / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000494:pharmacology
D000510:Alpha-Globulins; D000961:Antilymphocyte Serum; D012709:Serum Albumin; D012710:Serum Albumin, Bovine