[Action of perorally administered sodium ribonucleinate on RNA biosynthesis in the aortic, cardiac, liver and kidney tissue of animals with experimental diabetes mellitus].
Experiments were made on albino rats with alloxan diabetes. Half of the animals received sodium ribonucleate (20 mg/100 g) per os daily for two weeks. The intensity of RNA biosynthesis was judged from 32P incorporation. It was established that insulin deficiency abolished the biosynthesis of mitochondrial, cytoplasmic and nuclear RNA in the liver and kidneys, of mitochondrial and cytoplasmic RNA in the heart muscle, and of total RNA in the aorta tissue. Oral administration of sodium ribonucleate gave rise to the increased biosynthesis of RNA in these organs. A conclusion is drawn that oral application of the drug may be used in combined treatment of diabetes mellitus in general, and of that complicated by angiopathy, in particular.
D000284:Administration, Oral; D000818:Animals; D001011:Aorta / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009696:Nucleic Acids / Q000008:administration & dosage*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D009696:Nucleic Acids; D012313:RNA; C013683:sodium nucleinate
Deĭstvie peroral'no vvedennogo natriia ribonukleinata na biosintez RNK v tkaniakh aorty, serdtsa, pecheni i pochek u zhivotnykh s éksperimental'nym sakharnym diabetom.