Stimulation of neutrophil locomotion by inosiplex.
Experiments were performed to investigate the in vitro effects of inosiplex on the locomotion and oxidative metabolism of human neutrophils. The drug, when used at the concentration of 500 micrograms/ml, significantly increased neutrophil random migration and chemotaxis. Enhancement of chemotaxis was due to an increased rate of locomotion as well as toan increased true chemotactic response. Inosiplex appeared to exert its effect on the whole migrating cell population. No significant effect on the oxidative metabolism of both resting and phagocytizing neutrophils was found. The results suggest that the effect of inosiplex may be related chiefly to its effect on neutrophil locomotion.
D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006600:Hexosephosphates / Q000378:metabolism; D006801:Humans; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects*; D009712:Nucleotides, Cyclic / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D006600:Hexosephosphates; D009712:Nucleotides, Cyclic; D007288:Inosine; D007542:Inosine Pranobex