[Distribution of human interferon in organs and tissues after its administration to man and animals].
After intramuscular inoculation of interferon to mice and rabbits it accumulated in serum (6 hours after inoculation) and some organs (16 hours) and subsequently disappeared. Intravenous inoculation produced an earlier appearance (within 6 hours) of interferon in organs and more rapid disappearance. Neither intramuscular nor intravenous inoculation resulted in interferon penetration into the bone marrow. A similar picture was observed in children with acute leukemia after intramuscular inoculation of interferon. Inoculation of interferon into bones of the children resulted in its deposition for a few days in the bone marrow with subsequent transition into the blood stream.
D000818:Animals; D001853:Bone Marrow; D002648:Child; D006801:Humans; D007267:Injections; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007372:Interferons / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007938:Leukemia / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D011817:Rabbits; D014018:Tissue Distribution
D007372:Interferons
Rasprostranenie chelovecheskogo interferona po organam i tkaniam pri vvedenii ego cheloveku i zhivotnym.