The use of beta-thromboglobulin to detect platelet damage by therapeutic ultrasound in vivo.
Three sequential blood samples were drawn from arms of adult human volunteers by means of a cannula technique, and the plasma levels of beta-thromboglobulin (beta-TG an index of platelet damage) were measured. Ultrasound (0.75 MHz, continuous wave; spatially averaged intensity 0.34 to 0.5 W/cm-2) was applied to the blood vessels while the second sample of each series was being taken. No elevation of beta-TG was detected, indicating that under these conditions ultrasonic irradiation had not damaged an appreciable number of platelets. There was, however, an indication of decreased platelet sensitivity following insonation; and it is postulated that this may be the result of either increased production or secretion of the potent endothelial platelet inhibitor, prostacyclin, or both.
D000328:Adult; D001609:Beta-Globulins / Q000032:analysis*; D001792:Blood Platelets; D001831:Body Temperature; D006801:Humans; D008297:Male; D014465:Ultrasonics / Q000009:adverse effects*; D001620:beta-Thromboglobulin / Q000032:analysis*
D001609:Beta-Globulins; D001620:beta-Thromboglobulin