Antibody-dependent plaque enhancement: its antigenic specificity in relation to Togaviridae.
The antigenic specificity of antibody-dependent plaque enhancement (ADPE) on the macrophage cell line P388D1 has been investigated using viruses in the flavivirus and alphavirus genera. Whereas ADPE detected group-specific antigenic determinants in the flaviviruses, narrower specificity (type and subgroup) was seen with alphaviruses. ADPE titres correlated well with haemagglutination inhibition titres.
D000524:Alphavirus / Q000254:growth & development / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D002460:Cell Line; D003429:Cross Reactions; D000939:Epitopes; D005416:Flavivirus / Q000254:growth & development / Q000276:immunology*; D008264:Macrophages; D051379:Mice; D010948:Viral Plaque Assay
D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes