Partial splenic embolization using polyvinyl alcohol foam, dextran, polystyrene, or silicone. An experimental study in dogs.
Partial splenic arterial embolization (50% reduction in flow) was evaluated in dogs using polyvinyl alcohol foam or microspheres (20-500 mu) made of dextran, polystyrene, or silicone. Dextran and polystyrene were found to be superior for several reasons: they were easier to use, did not shatter when agitated, and produced permanent, homogeneous, peripheral occlusion with only one administration. Partial embolization with dextran or polystyrene increased platelet levels within 1 week and markedly reduced splenic size with minimal if any collateral filling within 6 weeks. Microscopically, no acute infarction or necrosis was seen at 6 weeks; there was some fibrosis, but the remaining parenchyma appeared normal.
D000818:Animals; D000837:Anion Exchange Resins; D003911:Dextrans; D004285:Dogs; D004621:Embolization, Therapeutic; D005782:Gels; D006971:Hypersplenism / Q000628:therapy; D007475:Ion Exchange Resins; D008863:Microspheres; D010976:Platelet Count; D011145:Polyvinyls; D012117:Resins, Synthetic; D012828:Silicones; D013157:Splenic Artery
D000837:Anion Exchange Resins; D003911:Dextrans; D005782:Gels; D007475:Ion Exchange Resins; D011145:Polyvinyls; D012117:Resins, Synthetic; D012828:Silicones; C026699:ivalon sponge; C013471:dextranomer; C027972:Dowex; C025614:sephadex