Combined protective effects on interferon and interferon induction on herpes simplex and ectromelia virus infections in mice.
Mouse interferon or the induction of mouse interferon with polyriboinosinic acid-polyribocytidylic acid significantly protected mice against herpes simplex and ectromelia viral infections. When polyriboinosinic acid-polyribocytidylic acid was administered 24 h before herpes simplex or ectromelia viral infection and mouse interferon was administered shortly before and 24 h after infection, a combined protective effect against either herpes simplex or ectromelia viral infection in mice was evident. There was a significant decrease in the mortality rate with the combined treatment as compared either with the rate in group treated with interferon or polyriboinosinic acid-polyribocytidylic acid.
D000818:Animals; D004359:Drug Therapy, Combination; D004482:Ectromelia, Infectious / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D006561:Herpes Simplex / Q000401:mortality / Q000517:prevention & control*; D007372:Interferons / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011070:Poly I-C / Q000627:therapeutic use*; D011213:Poxviridae Infections / Q000517:prevention & control*
D007372:Interferons; D011070:Poly I-C