The role of opioid receptor sub-types in tifluadom-induced feeding.
There is now considerable evidence that opioid agonists and benzodiazepines increase food and water intake in a variety of animal species. The appetitive effects of the novel opioid-benzodiazepine tifluadom have been investigated. (+/-)-Tifluadom significantly increased food intake in freely-feeding rats. This stimulation of appetite was attributable principally to the activity of the (+)-isomer. Furthermore tifluadom-induced feeding was blocked by the opioid antagonists naloxone, naltrexone, Mr 1452 and Mr 2266 but not by the delta-opioid receptor antagonist ICI 154, 129, or by the benzodiazepine antagonist Ro 15-1788. These results suggest that tifluadom exerts its effect on food intake by interaction with opioid as opposed to benzodiazepine receptors and that this activity is mediated by kappa and/or mu- rather than delta-opioid receptor sub-types.
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D001575:Benzomorphans / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D005442:Flumazenil; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*; D013237:Stereoisomerism
D001570:Benzodiazepinones; D001575:Benzomorphans; D003292:Convulsants; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D001569:Benzodiazepines; D009270:Naloxone; D005442:Flumazenil; C027247:MR 2266; D004743:Enkephalin, Leucine; D009271:Naltrexone; C029552:Mr 1452; C036405:ICI 154129; C035470:tifluadom