[Light and electron microscopic data on the characteristics of the utiliztion of amikin and aminozol, preparations for parenteral feeding].
It has been extablished that in the course of protein starvation in dogs, parenteral administration of amikin or aminozol normalizes, to a greater of less extent, the disturbed metabolism of proteins, nucleoproteins, glycogen and lipids. Electron microscopy has shown that the ingredients of the preparations enter the cells at an equal intensity from the microcirculatory bed by means of active transendothelial transport. In the course of utilization of the substances supplied to the cells, no marked changes were seen in protein synthesis or in its participation in intracellular reparative regeneration. There occurs a pronounced cytosegresomal response to unutilized substances accumulated by hepatocytes. The clinical efficacy of the preparations used is related to the processes of gluconeognesis of amino acids supplied as a result of which energy formation does not require structural or endogenously formed protein.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D004247:DNA / Q000378:metabolism; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000473:pathology; D008854:Microscopy, Electron; D009584:Nitrogen / Q000378:metabolism*; D010288:Parenteral Nutrition; D011488:Protein Deficiency / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D011492:Protein Hydrolysates / Q000378:metabolism*; D012313:RNA / Q000378:metabolism
D000596:Amino Acids; D011492:Protein Hydrolysates; C018816:amikin (amino acid); D012313:RNA; C010025:aminosol; D004247:DNA; D009584:Nitrogen
Osobennosti utilizatsii preparatov dlia parenteral'nogo pitaniia amikina i aminozola po dannym svetovoĭ i élektronnoĭ mikroskopii.