Reorganization of the axon membrane in demyelinated peripheral nerve fibers: morphological evidence.
Cytochemical staining of demyelinated peripheral axons revealed two types of axon membrane organization, one of which suggests that the demyelinated axolemma acquires a high density of sodium channels. Ferric ion-ferrocyanide stain was confined to a restricted region of axon membrane at the beginning of a demyelinated segment or was distributed throughout the demyelinated segment of axon. The latter pattern represents one possible morphological correlate of continuous conduction through a demyelinated segment and suggests a reorganization of the axolemma after demyelination.
D000818:Animals; D003711:Demyelinating Diseases / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D007473:Ion Channels / Q000378:metabolism*; D008297:Male; D009431:Neural Conduction; D009441:Neurilemma / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D013194:Staining and Labeling
D007473:Ion Channels