Sequestration of heat damaged rat erythrocytes during experimental action of methyl palmitate on RES.
The effect of an i.v. injection of methyl palmitate emulsion (MP) on the clearance of heat damaged erythrocytes from the blood and their sequestration in organs of rats was followed. Twenty-four hours following application of MP in the dose of 1.5 g/kg of body weight the survival half time of erythrocytes (T1/2(51)Cr) significantly increased, whereas the amount of sequestrated red cells in the spleen decreased. The subsequent intervals of examination, however, showed no differences as compared to the controls.
D000818:Animals; D004905:Erythrocyte Aging / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D006358:Hot Temperature; D008297:Male; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D009929:Organ Size; D010168:Palmitates / Q000494:pharmacology*; D010169:Palmitic Acids / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000187:drug effects
D010168:Palmitates; D010169:Palmitic Acids; C019012:methyl palmitate