Immune-type glomerulonephritis induced in the Brown-Norway rat with mercury-containing pharmaceutical products.
It has been shown that Brown-Norway rats develop an immune-type glomerulonephritis after treatment with various mercury-containing drugs. Anti-GBM antibodies were involved, at least in some animals. This glomerulonephritis induced a proteinuria. Strong evidence is given, suggesting that most mercury compounds, some of which, such as mercurial antiseptics, are widely used, could induce an immune-type glomerulonephritis. The question therefore arises, whether these drugs can be used any longer.
D000818:Animals; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000139:chemically induced / Q000276:immunology*; D008297:Male; D008622:Merbromin; D008627:Mercuric Chloride; D008628:Mercury; D011507:Proteinuria; D051381:Rats; D011914:Rats, Inbred BN
D008627:Mercuric Chloride; D008628:Mercury; D008622:Merbromin