[Antiviral and anticellular activity of human leukocytic and fibroblastic interferons in homo- and heterologous cells].
Investigations of the antiviral and antiproliferative activities of human alpha and beta interferons were carried out in homologous and heterologous cell cultures (EBTr and TR - human embryo trachea cells). Both interferons were shown to inhibit the cytopathic effect of vesicular stomatitis virus and incorporation of 3H-thymidine in homologous cells. In heterologous cells of bovine embryo trachea the antiviral and antiproliferative effect was observed only with human alpha interferon.
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007962:Leukocytes; D051379:Mice; D009522:Newcastle disease virus / Q000187:drug effects*; D051381:Rats; D013045:Species Specificity; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D007372:Interferons
Antivirusnaia i antikletochnaia aktivnost' leikotsitarnogo i fibroblastnogo interfronov v gomo- i geterologicheskikh kletkakh.