[Diaplacental influence on the disseminated intravascular coagulation (DIC) in an asphyxia model. I. Influence on the vasal tonus and on the vasal wall (author's transl)].
With the aid of an asphyxia model in rabbit fetuses the possibility of diaplacental influence on the hypoxic effects of the fetal organism has been investigated. The trial to change the vasotonia during the asphyctic shock by sympathicomimetic or -lytic drugs (Dilatol, Obsidan, Ergocomb, Regitin) remained to be without any effect on the DIC in the fetal organism. Trying to seal the vascular wall by the high-molecular-weight basic polypeptide Aprotinin there seemed rather to be an increase of the intravascular fibrin sedimentation.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use; D001808:Blood Vessels / Q000187:drug effects*; D004211:Disseminated Intravascular Coagulation / Q000628:therapy*; D005260:Female; D005315:Fetal Diseases; D005311:Fetal Hypoxia / Q000628:therapy*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011817:Rabbits
D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D007611:Aprotinin
Diaplazentare Einwirkung auf die disseminierte intravasale Gerinnung (DIC) im Asphyxiemodell I. Gefässtonus- und Gefässwandbeeinflussung.