Elicitation of natural killer cells in beige mice by infection with vesicular stomatitis virus.
Vesicular stomatitis virus (VSV) infection of beige (bg/bg) mice induced levels of natural killer cytolytic activity comparable to that of uninfected normal bg/+ controls, but considerably less than natural killer activity in VSV-infected bg/+ mice. In contrast, VSV-infected bg/bg and bg/+ mice had essentially equivalent amounts of anti-VSV cytotoxic T-lymphocyte and antibody activity. VSV infection induced comparable levels of interferon in both bg/bg and bg/+ mice. Therefore, the decreased natural killer activity in bg/bg mice could not be attributed to an inability to produce interferon.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000961:Antilymphocyte Serum / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic; D005260:Female; D006168:Guinea Pigs; D006183:H-2 Antigens / Q000276:immunology; D007372:Interferons / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology / Q000382:microbiology*; D008223:Lymphoma / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013280:Stomatitis / Q000276:immunology / Q000382:microbiology*; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000382:microbiology*
D000914:Antibodies, Viral; D000961:Antilymphocyte Serum; D006183:H-2 Antigens; D007372:Interferons