Natural killer and killer cell activities in patients with primary immunodeficiencies or defects in immune interferon production.
Natural cell-mediated cytotoxicity (NCMC) against K-562 target cells was explored in patients with various primary immunodeficiencies. (a) NCMC was present in 2 patients lacking detectable B cells. Conversely, NCMC was depressed in 2 patients with severe combined immunodeficiency presenting a normal number of circulating B cells. These data exclude a major role for B cells in NCMC. (b) NCMC was depressed mainly in patients with severe combined immunodeficiency or with defects affecting cellular immunity, which suggests a major role in NCMC for cells of T lineage. (c) Four patients with various clinical features associated with a lack of immune interferon production exhibited a strikingly depressed NCMC. Interferon thus appears as a major in vivo activator of natural killer (NK) cell activity. (d) Eight patients exhibiting a depressed NK cell activity had a normal killer (K) cell activity against L1210 cells in the presence of rabbit anti-L1210 antiserum. These data are consistent with the assumption that NK and K cell activity are mediated through two distinct cellular mechanisms.
D000293:Adolescent; D000920:Antibody-Dependent Cell Cytotoxicity; D002648:Child; D002675:Child, Preschool; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007223:Infant; D007372:Interferons / Q000172:deficiency*; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male
D007372:Interferons