Studies on an interferon-sensitive mutant of mengovirus: effects on host RNA and protein syntheses.
Interferon induces an activity which strongly inhibits the growth of is-1, an interferon-response mutant of mengovirus. This activity is not expressed in protected cells infected with either is+ (the wild-type parent) or vaccinia virus, or in cells infected with is-1 in the presence of actinomycin D. A failure of is-1 to shut off host RNA and/or protein synthesis could explain these observations. The present paper, however, shows that is-1 and is+ are equally effective in suppressing host synthesis, and suggests that is+ actively inhibits the interferon-mediated activity directed against is-1.
D000818:Animals; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D008574:Mengovirus / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009154:Mutation; D011061:Poly A / Q000096:biosynthesis; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D012333:RNA, Messenger
D012333:RNA, Messenger; D011061:Poly A; D012313:RNA; D007372:Interferons