[Effect of prednisolone on the intensity of nucleic acid synthesis by granulation tissue fibroblasts].
An experimental study was made of the effect exerted by prednisolone in a dose of 4 mg/kg body weight on wound healing. It was shown that prednisolone reduces the period of inflammation, accelerates the formation of granulation tissue and epidermis. All these effects are accompanied by diminution of the mitotic activity of fibroblasts and dramatic increase in the intensity of RNA synthesis in them. Dislocation of newly synthetized RNA from the nucleus to the cytoplasm proceeds at a greater rate as compared to control. The differentiation of fibroblasts is accelerated.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000378:metabolism*; D006097:Granulation Tissue / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009132:Muscles / Q000293:injuries; D011239:Prednisolone / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D012867:Skin / Q000293:injuries; D014529:Uridine / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects
D012313:RNA; D004247:DNA; D011239:Prednisolone; D014529:Uridine
Vliianie prednizolona na intensivnost' sinteza nukleinovykh kislot fibroblastami granuliatsionnoĭ tkani.