[Neuropeptides and psychiatry report presented at the French-Swiss Psychiatric meeting in Bel-Air, Geneva, 4 May 1980].
In this mini-review the definition, some localizations and effects of 18 neuropeptides (as known at the beginning of 1980) are recalled, as well as some of the methods used. The hypothesis that neuropeptides may modify both functions and structures is presented. After a brief comment on the neuropeptides/monoamines relations and on some pharmacological results, the possible implications of neuropeptides dysfunctions in various psychiatric disorders are discussed. Some facts leading to the suspicion that both substance P and endorphines are increased in some psychoses are mentioned. The results of therapeutic trials are discussed. The importance of neuropeptides for the maintenance of internal homeostasis and behavioural adjustments is stressed.
D000818:Animals; D001519:Behavior / Q000502:physiology; D001921:Brain / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011618:Psychotic Disorders / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013373:Substance P / Q000378:metabolism
D004723:Endorphins; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter; D013373:Substance P
Neuropeptides et psychiatrie. (texte du rapport présenté à la réunion Franco-Suisse de Psychiatrie, à Bel-Air, Genève, le 4 mai 1980).