Abnormalities of erythrocyte stromal lipids in atresia of the intrahepatic bile ducts.
Detailed analysis of plasma and erythrocytes lipid composition of patient with intrahepatic biliary atresia is presented. Abnormalities have been outlined and are characterized as following: (1) an increase of total cholesterol compounds and total phospholipids in serum; (2) an increase of free cholesterol and lecithin up to 50 per cent of total phosphatides in red cells; (3) the fatty-acids pattern isolated from total phospholipids of red cells shows a rise of palmitic and palmitoleic acids and a decrease of stearic and longer-chain fatty acids; (4) in PC and PE of red cells, there is an overall tendency for the degree of unsaturation of long-chain fatty acids to increase. In addition to these lipid changes, it was demonstrated by polyacrylamide-gel electrophoresis that the composition of membrane proteins was normal. It is of particular interest to establish whether these abnormalities are either induced by complex metabolic pathways and exchange processes between the lipids of circulating erythrocytes and the altered lipids of serum environment or are the direct result of modified hepatic cellular or enzymatic function.
D001653:Bile Ducts, Intrahepatic / Q000002:abnormalities*; D002648:Child; D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008565:Membrane Proteins / Q000097:blood; D010743:Phospholipids / Q000097:blood
D005227:Fatty Acids; D008055:Lipids; D008565:Membrane Proteins; D010743:Phospholipids; D002784:Cholesterol