IgE antibodies for penicillins and cephalosporins in rats. III. Antigenic specificity of rat anti-cephalosporin-OvA IgE sera.
Sprague Dawley (SD) rats were immunized with various cephalosporin- and penicillin-ovalbumin (OvA) in combination with aluminium hydroxide (alum) and thimerosal-killed Bordetella pertussis. Anti-cephalosporin IgE antibody production was inferior to anti-penicillin IgE antibody production. Cefsulodin (CFS), sulbenicillin (SBPC) and alpha-sulfophenyl acetic acid (SPAA) cross-reacted with each other but did not react with cephaloridine (CER), cefazolin (CEZ) and penicillin G (PCG). CER and PCG slightly cross-reacted with each other but did not cross-react with the others tested. Anti-CFS and anti-SBPC IgE sera were related specifically to the SPAA moiety.
D000818:Animals; D000917:Antibody Formation; D002511:Cephalosporins / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes; D006241:Haptens / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D010406:Penicillins / Q000276:immunology*; D051381:Rats
D002511:Cephalosporins; D000939:Epitopes; D006241:Haptens; D007106:Immune Sera; D010406:Penicillins; D007073:Immunoglobulin E; D010047:Ovalbumin