The antihypertensive effect of taurine in DOCA-salt rats.
We studied the role of the sympathetic nervous system in the antihypertensive actions of taurine in DOCA (deoxycorticosterone acetate)-salt hypertensive rats. Supplementation with 1% taurine could moderate the development of the DOCA-salt hypertension. Norepinephrine turnover was measured from the rate of decline of tissue norepinephrine concentration after the administration of alpha-methyl-p-tyrosine. Cardiac and splenic norepinephrine turnover was markedly accelerated in the DOCA-salt rats compared with the vehicle-treated control rats, but the 1% taurine supplements could normalize this. These results suggest that the normalization of the increased sympathetic activity may be involved in the antihypertensive actions of taurine in DOCA-salt hypertensive rats.
D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009392:Nephrectomy; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000187:drug effects; D013654:Taurine / Q000627:therapeutic use*; D014446:Tyrosine 3-Monooxygenase / Q000037:antagonists & inhibitors
D000959:Antihypertensive Agents; D013654:Taurine; D003900:Desoxycorticosterone; D014446:Tyrosine 3-Monooxygenase; D009638:Norepinephrine