title: Binding of beta 2-microglobulin by heterologous sera.
abstract: Purified human, rat or guinea-pig beta 2-microglobulin (beta 2m) was mixed with sera from guinea-pig, rat, mouse, rabbit, horse, goat, cow, rhesus monkey or man. The mixtures were incubated at 37 degrees C for various lengths of time. When the sera were separated by gel-chromatography on Sephadex G-200, beta 2m was traced not only in 'free' form but also in fractions with higher molecular weights. Evidence is presented suggesting that heterologous beta 2m binds to beta 2m-containing molecules in sera by exchange with the homologous counterpart.
mesh_terms: D000818:Animals; D001609:Beta-Globulins / Q000276:immunology*; D002850:Chromatography, Gel; D006801:Humans; D011485:Protein Binding; D011863:Radioimmunoassay; D013696:Temperature; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000276:immunology*
chemical_list: D001609:Beta-Globulins; D001613:beta 2-Microglobulin