Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice.
Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects; D009619:Nociceptors / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology; D013373:Substance P / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D013373:Substance P; D009020:Morphine