Follow-up of blood donors positive for hepatitis B surface antigen.
From 1973 to 1977 in Amsterdam the incidence of hepatitis B surface antigen (HBsAg) in blood donations from new donors was 0.224 and from known donors 0.034%. 65 donors, previously found positive for HBsAg, were re-examined. Persistence of HBsAg in new donors (28 of 31) occurred significantly (p less than 0.0005) more often than in known donors (15 of 34). All carriers were classified into HBeAg (21%) or anti-HBe (79%) by a sensitive Elisa technique. Abnormal liver function tests (LFTs) were observed in 30% of the carriers and were significantly (p less than 0.005) more often found in HBeAg than in anti-HBe-positive carriers. When the LFTs remained abnormal, in almost all (8 of 9) carriers moderate to severe histological liver disease was diagnosed.
D001782:Blood Donors; D002353:Carrier State / Q000276:immunology; D000939:Epitopes; D005260:Female; D005500:Follow-Up Studies; D006386:Hemagglutination Tests; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009426:Netherlands
D000939:Epitopes; D006514:Hepatitis B Surface Antigens