Regional differences in microvascular responses in generalized scleroderma.
In 7 patients suffering from generalized scleroderma of the acrosclerosis type, a decreased reactivity towards changes in vascular transmural pressure was observed in subcutaneous tissue of finger, as compared with arm. Clinically, the fingers were regularly found to be more severely involved in the sclerodermal process, and the pathologic microvascular responses seem to parallel the tissue pathology.
D000328:Adult; D000368:Aged; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply