[Human gammaglobulin tolerance: shared idiotypy of T-cell suppressor factor and antibodies (author's transl)].
A factor from human gammaglobulin (HGG) high-zone-tolerant CBA splenic T cells has been produced in optimal conditions after a 16-h culture in CBA mice. A CBA anti-(CBA anti-HGG) serum, purified on HGG, and referred to as antiidiotypic serum, has been coupled to Sepharose-4B. The factor can be adsorbed by this antiidiotypic serum but to a smaller extent than by anti-Iak. The existence of shared idiotypic determinants by factor and antibodies is discussed.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D007108:Immune Tolerance; D007130:Immunoglobulin Idiotypes; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes; D005719:gamma-Globulins
Tolérance à haute dose à la gammaglobuline humaine: idiotypie croisée du facteur suppressif et des anticorps anti-HGG.