Cytotoxic-induced fulminant hyperpyrexia.
Two cases of fulminant hyperpyrexia induced by cytotoxic agents (bleomycin in a patient with lymphoma, and daunorubicin in a patient with acute myeloblastic leukemia) are presented. Each patient had a fever greater than 42 degrees C, with a shock-like reaction and coma. Evidence of disseminated intravascular coagulopathy developed in the patient with bleomycin-induced hyperpyrexia and she died 24 hours afterwards. The pathogenesis and management of hyperpyrexial reactions to cytotoxic drugs are discussed.
D000328:Adult; D001761:Bleomycin / Q000009:adverse effects*; D003630:Daunorubicin / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008875:Middle Aged; D011749:Pyrogens / Q000378:metabolism
D011749:Pyrogens; D001761:Bleomycin; D003630:Daunorubicin