[Reaction of the Gomori-positive hypothalamo-hypophyseal neurosecretory system of the rat to a single dose of thyroliberin].
A decrease in the functional neurosecretory cell activity of the rat hypothalamic supraoptical and paraventricular nuclei was seen 30 minutes after a single intramuscular thyroliberin injection (8 micrograms). The size of the neurosecretory cell nucleoli significantly diminished in both centers, while a large amount of intranuclear nucleoli-like bodies appeared in the paraventricular nucleus. The neurosecretory substance content in the posterior hypophysis significantly decreased, indicating an active neurohormone excretion. A possibility of negative feedback between the body thyroliberin level and the state of the Gomori-positive hypothalamic neurosecretory centers is discussed.
D000818:Animals; D003864:Depression, Chemical; D006728:Hormones / Q000008:administration & dosage; D007031:Hypothalamus / Q000378:metabolism*; D007273:Injections, Intramuscular; D008297:Male; D009489:Neurosecretion / Q000187:drug effects; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000378:metabolism*; D051381:Rats; D013194:Staining and Labeling; D013495:Supraoptic Nucleus / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage*
D006728:Hormones; D013973:Thyrotropin-Releasing Hormone
Reaktsiia Gomoripolozhitel'noĭ gipotalamo-gipofizarnoĭ neĭrosekretornoĭ sistemy krysy na odnokratnoe vvedenie tiroliberina.