Transfer factor treatment in bullous pemphigoid. Impaired T cell function.
A patient with bullous pemphigoid, not responding to prednisone, had impaired cellular immunity. Transfer factor (TF) was given in doses of 10 U/m2 intramuscularly to improve T cell immunity, at a frequency of 3 times to once a week. Clinical improvement fluctuated with changes in the frequency of TF injections. The skin has been clear of the lesions for the past 9 months. Her T cell functions became normal and serum IgE decreased from 900 U/ml to 270 U/ml. She has received a total of 1,732 U of TF. This report is intended to encourage investigation into T cell functions in patients with bullous pemphigoid and controlled trials of TF in this disease.
D001327:Autoimmune Diseases / Q000276:immunology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007372:Interferons / Q000502:physiology; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014165:Transfer Factor / Q000008:administration & dosage / Q000627:therapeutic use*
D014165:Transfer Factor; D007372:Interferons