title: Effect of triiodothyronine on renal growth and renal sodium reabsorption in hypothyroid rats.
abstract: Experiments were carried out to compare temporal changes in the paraaminohippuric acid clearance (CPAH), renal sodium reabsorption (RNa+), ribonucleic acid (RNA), and deoxyribonucleic acid (DNA) content in hypothyroid rats after a single injection of triiodothyronine (T3) (50 micrograms/100 g body wt). CPAH and RNa+ showed no changes at 24 and 48 h. At 72 h, however, significant increases of 41% and 42% (per g kidney wet wt) were observed in CPAH and RNa+, respectively. The cortex in T3-treated hypothyroid rats showed a significant increase in the protein/DNA and RNA/DNA ratios at 24 h and progressive increases to a level of 24%, and 37%, respectively, at 48 h. No changes in DNA content were observed at either time-points. The results show that the increases in RNA/DNA and protein/DNA ratios upon T3 treatment preceded the increases in CPAH and RNa+, suggesting a direct effect of T3 on renal cortical growth, rather than a secondary response to a primary increase in renal functions.
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D007037:Hypothyroidism / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D008297:Male; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D014284:Triiodothyronine / Q000494:pharmacology*; D010130:p-Aminohippuric Acid / Q000378:metabolism
chemical_list: D011506:Proteins; D014284:Triiodothyronine; D012313:RNA; D004247:DNA; D012964:Sodium; D010130:p-Aminohippuric Acid