title: Studies on retinal neovascularization. Friedenwald Lecture.
abstract: Evidence supporting the original concept of Michaelson and Ashton of a vasoproliferative or angiogenesis factor responsible for retinal neovascularization is discussed. The oxygen model of retinal neovascularization is described as a key example in this evidence. Newer studies on experimental retinal neovascularization and its control are summarized.
mesh_terms: D000368:Aged; D043925:Angiogenesis Inducing Agents / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002415:Cats; D003930:Diabetic Retinopathy / Q000209:etiology; D004285:Dogs; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D009389:Neovascularization, Pathologic; D010100:Oxygen / Q000009:adverse effects*; D011817:Rabbits; D012164:Retinal Diseases / Q000209:etiology*; D012171:Retinal Vessels / Q000473:pathology*; D012178:Retinopathy of Prematurity / Q000209:etiology
chemical_list: D043925:Angiogenesis Inducing Agents; D010100:Oxygen