The ontogeny of substance P fibers in the mouse trigeminal nerve.
The putative neurotransmitter substance P was localized in the embryonic and neonatal mouse trigeminal nerve by indirect immunofluorescence. Central terminals in the nucleus caudalis gave a positive substance P-like immunofluorescence (SPLI) reaction of E13-E14. SPLI subsequently appeared in the peripheral mucous and cutaneous nerves at E16-17 at which time trigeminal nucleus cell bodies were also positive. These findings indicate the early development of primary afferent nociceptive pathways.
D000375:Aging; D000818:Animals; D005260:Female; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D051379:Mice; D009092:Mucous Membrane; D010614:Pharynx / Q000294:innervation; D011247:Pregnancy; D013373:Substance P / Q000032:analysis*; D014276:Trigeminal Nerve / Q000196:embryology* / Q000254:growth & development
D013373:Substance P