Reduction of pituitary nucleic acids, proteins, LH and FSH by melatonin-free pineal extract in rats stimulated with gonadotropin releasing hormone.
The effect of a pineal treatment on the pituitary gland under exogenous stimulation with gonadotropin releasing hormone (GnRH) was assessed in the rat. A pretreatment with melatonin-free pineal extract under the above conditions caused a statistically significant decrease in the pituitary concentrations of DNA--by 21%, RNA--by 28%, proteins--by 19%, LH--by 25% and FSH--by 22%. Authors' findings show that the melatonin-free pineal extract plays a role in the metabolism of nucleic acids and pituitary proteins besides being implied in the synthesis of gonadotropic hormones.
D000818:Animals; D004247:DNA / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000502:physiology; D010870:Pineal Gland / Q000502:physiology*; D010902:Pituitary Gland / Q000378:metabolism*; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology
D010906:Pituitary Hormone-Releasing Hormones; D011506:Proteins; D014020:Tissue Extracts; D012313:RNA; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004247:DNA; D008550:Melatonin