Pneumococcal vaccination in patients with chronic renal disease and renal allograft recipients.
Polyvalent pneumococcal vaccine was administered to 7 patients with chronic renal failure, 14 patients on chronic hemodialysis, 14 splenectomized and 11 nonsplenectomized renal allograft recipients, and 14 normal adults. Ninety-three percent of normal subjects had at least a twofold rise in serum antibody concentration after vaccination, with a geometric mean antibody concentration after vaccination greater than 200 ng N/ml. The response to vaccination in hemodialysis patients was similar to that in normal persons. Renal failure patients showed impaired antibody synthesis in response to the vaccine, with 43% achieving at least a twofold rise in antibody concentration. Allograft recipients had a lower antibody concentration before as well as after vaccination, and among splenectomized recipients the prevaccination antibody concentration was directly related to the interval between transplantation and antibody determination. But, 80% of allograft recipients achieved a twofold rise in antibody concentration after vaccination. The response to pneumococcal vaccine was quantitatively similar for splenectomized and nonsplenectomized allograft recipients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D001428:Bacterial Vaccines; D000939:Epitopes; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000517:prevention & control*; D006435:Renal Dialysis; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014181:Transplantation Immunology; D014611:Vaccination
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D000939:Epitopes