[Do the HLA-A2 genes prevent tumor development? A hypothesis].
The statistical evaluation of the results of 22 HLA antigen typing in 132 patients with tumors (Wilms' tumor, neuroblastoma, germinative testicular non-seminoma-like tumors, benign teratomata) which are probably of common origin during early embryogenesis showed a substantial, after correction of p an insignificant decrease of HLA-A2 frequency against 301 controls. The lower frequency of HLA-A2 was also found in some other tumors. A hypothesis on the protective action of HLA-A2 against tumor development was proposed. The mechanism of this phenomenon may utilize the enhancing effect of HLA-A2 gene on the membrane and humoral immune reactivity of the organism, thus presenting an analogy of HLA-A2 effect on the survival of renal graft and transfused thrombocytes.
D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000235:genetics*; D013724:Teratoma / Q000235:genetics*; D013736:Testicular Neoplasms / Q000235:genetics*; D009396:Wilms Tumor / Q000235:genetics*
D006680:HLA Antigens
Schützen die HLA-A2-Gene vor der Entwicklung eines Tumors? Eine Hypothese.