title: [Modification of the half-life of poly (A+)mRNA in liver and brain cells of the rat during embryogenesis and postnatal development].
abstract: The poly(A+)/poly(A-)mRNA ratio and the half-life time of poly(A+)mRNA for mRNA metabolism in the liver and brain of rat in the course of ontogensis, late embryogenesis, postnatal development and upon ageing were determined. It was shown that in the course of ontogenesis both the ratio of poly(A+)/poly(A-)mRNA of free and membrane-bound polyribosomes and the half-life time of poly(A+)mRNA determined from the degradation kinetics in the presence of actinomycin D are changed. A possible role of poly(A) sequences in the regulation of mRNA life-time is discussed.
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D004622:Embryo, Mammalian; D006207:Half-Life; D007700:Kinetics; D008099:Liver / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D011061:Poly A / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D012333:RNA, Messenger; D051381:Rats
chemical_list: D012333:RNA, Messenger; D011061:Poly A; D012313:RNA
vernacular_title: Moduliatsiia vremeni poluzhizni poli (A+)mRNK v kletkakh pecheni i mozga krys v embrional'nom i postnatal'nom razvitii.