Artificial excretion of weakly bound middle molecules by hemoanadiafiltration.
The concept of a subtractive therapeutic intervention in several diseases (shock, acute liver, failure, poisoning) to remove toxic middle molecules (MM) has led to the devising of a particular ultrafiltration system (anadiafiltration) to clear weakly bound MM. Clinical hemoanadiafiltration (HADF) with a polyacrylonitrile filter and in vitro experiments with a series of marker substances, have shown HADF efficacy in clearing MM, irrespective of their molecular weight, with protein binding K between 50 and 150.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002417:Cattle; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009369:Neoplasms / Q000097:blood; D010455:Peptides / Q000097:blood* / Q000378:metabolism; D011485:Protein Binding; D014118:Toxins, Biological / Q000097:blood; D014462:Ultrafiltration / Q000379:methods*; D005719:gamma-Globulins / Q000378:metabolism
D001798:Blood Proteins; D010455:Peptides; D014118:Toxins, Biological; D005719:gamma-Globulins