Sister-chromatid exchanges: a report of the GENE-TOX program.
The effects of a number of chemicals on sister-chromatid exchange (SCE) frequencies in in vivo and in vitro systems are reviewed. Standardized protocols for future SCE testing in important systems, as well as for evaluation of test results, are presented. Data reported thus far suggest that SCE analysis may prove useful, especially at a secondary level, as a test of mutagenic carcinogens. Strengths and limitations of SCE analysis are summarized as a guide for future evaluation and use of this procedure.
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D001973:Bromodeoxyuridine; D002273:Carcinogens / Q000494:pharmacology; D002642:Chick Embryo; D002875:Chromosomes / Q000187:drug effects; D006224:Cricetinae; D003434:Crossing Over, Genetic / Q000187:drug effects; D003584:Cytological Techniques; D004247:DNA / Q000235:genetics; D006801:Humans; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013194:Staining and Labeling
D000477:Alkylating Agents; D002273:Carcinogens; D009153:Mutagens; D004247:DNA; D001973:Bromodeoxyuridine