Lipoxygenase inhibitors exert secretagogue-specific effects on mast cell exocytosis.
The lipoxygenase inhibitors HTYA (5,8,11,14-henicosatetraynoic acid, 25-150 microM) and ITYA (4,7,10,13-icosatetraynoic acid, 25-75 microM), inhibited histamine secretion from rat mast cells evoked by concanavalin A but that elicited by compound 48/80 or polymyxin B. Arachidonic acid (100 microM) did not inhibit concanavalin A-induced histamine secretion. The results are consistent with the notion that lipoxygenase inhibitors affect an early stage of stimulus-secretion coupling in the mast cell, peculiar to antibody-directed secretagogues, perhaps that involving calcium influx.
D015117:5,8,11,14-Eicosatetraynoic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D005089:Exocytosis / Q000187:drug effects*; D006636:Histamine Release / Q000187:drug effects; D016859:Lipoxygenase Inhibitors; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D011112:Polymyxin B / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D016859:Lipoxygenase Inhibitors; D003208:Concanavalin A; D015117:5,8,11,14-Eicosatetraynoic Acid; C029511:5,8,11,14-heneicosatetraynoic acid; D003189:p-Methoxy-N-methylphenethylamine; C029510:4,7,10,13-eicosatetraynoic acid; D011112:Polymyxin B