Retrogradely transported nerve growth factor increases ornithine decarboxylase activity in rat superior cervical ganglia.
Nerve growth factor (NGF) transported intraaxonally from the adrenergic nerve terminals in the iris to the cell bodies in the superior cervical ganglion resulted in an increase in the activity of the enzyme ornithine decarboxylase in the ganglion. This occurred in both six-day-old and adult rats with the relative effect of the retrogradely transported NGF being greater in adult animals. These results suggest that the induction of ornithine decarboxylase by NGF may be due to the stimulation of intracellular receptors.
D000375:Aging; D000818:Animals; D001370:Axonal Transport; D002262:Carboxy-Lyases / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D007700:Kinetics; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D009414:Nerve Growth Factors; D014446:Tyrosine 3-Monooxygenase; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase