[Formation of immune interferon and blast transformation in stimulated cultures of human lymphocytes].
Lymphocyte blast transformation (LBT) and interferon (IF) production were studied in 55 phytohemagglutinin- and dry purified tuberculin-stimulated lymphocyte cultures obtained from normal subjects (7 adults and 24 children). A relationship has been disclosed between LBT and interferon production. However, in some of the culture with marked LBT there occurred a defective IF production. On the contrary, with suppressed PHA-induced transformation, IF production was within normal. The role of the interferon production test for estimation of the functional activity of human lymphocytes is discussed.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D014373:Tuberculin / Q000494:pharmacology*
D010835:Phytohemagglutinins; D014373:Tuberculin; D007372:Interferons
Obrazovanie immunogo interferona i blastnaia transformatsiia v stimulirovannykh kul'turakh limfotsitov cheloveka.