Generation of immune specificity: a working hypothesis.
A speculative model for epigenetic generation of immune specificity is presented. It is based on the idea that combinatorial splicing within the same pre-mRNA molecule could generate a variety o mRNAs leading to a diversity of immunoglobulins. The model postulates a special role for the nuclear envelope where translation of intron sequences into messenger maturation proteins would take place. The postulates are justified and experimental implications of the model are discussed.
D000939:Epitopes; D008962:Models, Theoretical
D000939:Epitopes