title: [Ultrastructural changes in hepatocyte nuclei reflecting genome expression and nuclear RNA biosynthesis in the early premitotic period of rat liver regeneration].
abstract: Modifications of the nucleus ultrastructure and specific radioactivity of nuclear and cytoplasmic RNA from hepatocytes were studied at early stages of liver regeneration using 14C-orotic acid as a labelled precursor. It is shown that the first three hours after partial hepatectomy are characterized by mobilization of inherent abilities of the nucleus and initiation of chromatin activation. Then three hours after operation the activity of nucleolar and extranucleolar apparatus increases. By 12 hours chromatin associates with a nuclear membrane for preparing DNA replication.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D005786:Gene Expression Regulation; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000502:physiology / Q000648:ultrastructure*; D008115:Liver Regeneration; D008297:Male; D008854:Microscopy, Electron; D008938:Mitosis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013997:Time Factors
chemical_list: D012313:RNA
vernacular_title: Ul'trastrukturnye izmeneniia iader gepatotsitov, otrazhaiushchie ékspressiiu genoma, i biosintez iadernoĭ RNK v rannem predmitoticheskom periode regeneratsii pecheni krys.