Studies on the H2-receptor antagonism of MK-208 in isolated rabbit gastric glands.
Using isolated rabbit gastric glands, the H2-receptor antagonist MK-208 was investigated with respect to its effects on [14C]aminopyrine uptake as an index of gastric acid secretion. In addition to shifting the histamine concentration-response curve to the right in a parallel fashion, the antagonism produced by MK-208 was reversible, contrary to that previously seen in the guinea pig atria. These observations suggest that the H2-receptors responsible for mediating gastric secretion in the rabbit and the chronotropic response in guinea pig atria are different.
D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D005088:Exocrine Glands / Q000187:drug effects* / Q000378:metabolism; D015738:Famotidine; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D006635:Histamine H2 Antagonists; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D013844:Thiazoles / Q000494:pharmacology*
D006635:Histamine H2 Antagonists; D013844:Thiazoles; D000632:Aminopyrine; D015738:Famotidine