Evidence for linkage of murine beta 2-microglobulin to H-3 and Ly-4.
Murine beta 2-microglobulin exists in 2 electrophoretically distinct forms; C57BL/6 mice possess the basic allele whereas BALB/c, CBA, AKR, and NZB possess the acidic allele. Mice heterozygous for beta 2-microglobulin express both alleles. Analysis of recombinant inbred mice suggests linkage of beta 2-microglobulin to H-2 or H-3. B10.C (28NX) mice (which possess the H-3c allele of BALB/c on a C57BL/10 background) possess the acid allele. Taken together, these results are consistent with the beta 2-microglobulin gene lying on chromosome 2, and being linked to H-3 and Ly-4.
D000483:Alleles; D000818:Animals; D001609:Beta-Globulins / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000276:immunology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D001613:beta 2-Microglobulin / Q000235:genetics*
D001609:Beta-Globulins; D006183:H-2 Antigens; D001613:beta 2-Microglobulin