In vitro influence of theophylline on anti-IgE-induced release from leucocytes and whole blood in asthmatic children.
Two groups of asthmatic children were found with regard to the influence of theophylline on the anti-IgE-induced histamine release from whole blood. In th first group (21 children), histamine release was obtained both from whole blood and washed leucocytes and was inhibited by 10(-4) M theophylline. In the second group (5 children), histamine release required the presence of plasma and was not inhibited by 10(-4) M theophylline. Theophylline treatment was efficacious only in children of the first group.
D000293:Adolescent; D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D013806:Theophylline / Q000494:pharmacology*
D007073:Immunoglobulin E; D013806:Theophylline