Induction of somatic and male crossing-over by bleomycin in Drosophila melanogaster.
Bleomycin (BLM) is well known as an antibiotic as well as for its antineoplastic activity. A clinical preparation of BLM was tested for its recombinogenicity in a higher eukaryotic organism, Drosophila melanogaster. Feeding of the F1 larvae on a medium with BLM increased somatic crossing-over spots on female tergites and induced recombination in male germ cells. However, nonlinear dose-response curves were obtained. Malformed tergites were also observed in females treated with BLM.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D008297:Male; D010641:Phenotype; D013090:Spermatocytes / Q000648:ultrastructure
D001761:Bleomycin