[Quantitative changes of rat's alpha 2 macroglobulin concentration by influence of carbon tetrachloride (author's transl)].
We examined the influence of carbon tetrachloride on the rat liver by means of some biological parameters (body mass, GPT-activity, time of hexobarbital narcosis, aminophenazone demethylation) in comparison to the relative concentration of alpha 2 AP under conditions of a long time experiment (8 weeks). The results show, that merely the alpha 2 AP is altered significant in test groups after 1 d of treatment in comparison to the other parameters. Afterwards, under lasting carbon tetrachloride influence the macroglobulin decreases below normal levels. The potential diagnostic value of the alpha 2 AP for toxicological examinations is discussed.
D000410:Alanine Transaminase / Q000378:metabolism; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D006591:Hexobarbital / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D000511:alpha-Macroglobulins / Q000378:metabolism*
D000511:alpha-Macroglobulins; D000632:Aminopyrine; D006591:Hexobarbital; D000410:Alanine Transaminase
Quantitative Veränderungen des alpha 2 Makroglobulins der Ratte unter Tetrachlorkohlenstoffbelastung.