title: [Comparative systemic analysis of experimental models of chemical hepatic carcinogenesis in the rat].
abstract: The aim of this work is to compare several experimental protocols inducing hepatocarcinogenesis in the rat. The results show that the experimental protocols using an initiator and a promotor are not equivalent (in term of latency period and premalignant lesions) to experimental protocols using a chronic administration of one carcinogenic compound.
mesh_terms: D015073:2-Acetylaminofluorene; D000818:Animals; D004052:Diethylnitrosamine; D008099:Liver / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D009602:Nitrosamines; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism
chemical_list: D009602:Nitrosamines; D004052:Diethylnitrosamine; C002741:N-nitrosomorpholine; D015073:2-Acetylaminofluorene; D005723:gamma-Glutamyltransferase
vernacular_title: Analyse systémique comparative de modèles expérimentaux de cancérogenèse hépatique induite chimiquement chez le rat.