[Pathomechanism of dyskinesia associated with treatment of Parkinson disease with levodopa].
The 5-HIAA/HVA ratio was determined in the cerebrospinal fluid in 5 patients with Parkinson's disease with L-DOPA preparations in which drug-induced  dyskineses developed, in 5 patients treated with L-DOPA without dyskineses, and 10 controls. A decrease in the 5-HIAA/HVA ratio was observed in the group with dyskineses as compared with patients without dyskineses and in controls. The directions of further investigations on hte pathomechanism of drug-induced dyskineses are discussed.
D004409:Dyskinesia, Drug-Induced / Q000134:cerebrospinal fluid / Q000209:etiology*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000188:drug therapy
D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid
W sprawie patomechanizmu dyskinez zwiazanych z leczeniem choroby parkinsona preparatami L-dopa. Doniesienie wstepne.