Expression of Lyt-1 by a subset of B lymphocytes.
Using two-color flow cytometry and multiparameter data analysis, we have shown that the IgM bright, large subset of mouse splenic B lymphocytes express Lyt-1. This is not due to B cell uptake of immune complexes of Lyt-1 and antibody from T cells. The IgM bright cells of autoimmune NZB mice express more Lyt-1 than normal controls. This is because IgM containing plasmablasts, which are greatly increased in NZB spleens, are Lyt-1+. NZB spleen also contains more cells that are Lyt-1+ (but perhaps Lyt-1.2-), Thy-1.2 dull, and smaller in size than cells in normal mice. Thus, Lyt-1 is common to the T and B cell precursor or is induced independently during the ontogeny of T and at least one subset of B cells. We suggest that it be called Lyt-1.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics* / Q000276:immunology; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology; D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology*; D001666:Binding Sites, Antibody; D002469:Cell Separation; D000939:Epitopes / Q000235:genetics; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D007075:Immunoglobulin M / Q000235:genetics / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D051381:Rats; D011917:Rats, Inbred Lew; D011961:Receptors, Fc; D013154:Spleen / Q000166:cytology / Q000276:immunology; D018800:Thy-1 Antigens
D000950:Antigens, Ly; D000954:Antigens, Surface; D000939:Epitopes; D007075:Immunoglobulin M; D011961:Receptors, Fc; D018800:Thy-1 Antigens