Tryptophol-induced change in Brain 5-hydroxytryptamine Metabolism.
The effects of tryptoiphol (TOL) on brain 5-hydroxytryptamine (5-HT) metabolism were studied. After TOL injection (200 mg/kg IP), brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels were increased, 5-HT synthesis rate was decreased, and monoamine oxidase (MAO) activity remained unchanged. Pretreatment of mice with p-chlorophenylalanine (PCPA), a potent inhibitor of 5-HT synthesis, did not affect the anticonvulsant action of TOL.. These results suggest that alteration of 5-HT metabolism after TOL injection is not directly related to the anticonvulsant action of TOL
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008995:Monoamine Oxidase / Q000378:metabolism; D010433:Pentylenetetrazole / Q000494:pharmacology; D012701:Serotonin / Q000096:biosynthesis / Q000378:metabolism*; D000438:Alcohols
D000927:Anticonvulsants; D010134:Fenclonine; D006897:Hydroxyindoleacetic Acid; D007211:Indoles; D008995:Monoamine Oxidase; D010433:Pentylenetetrazole; D012701:Serotonin; C005949:tryptophol; D000438:Alcohols