Sinoaortic denervation-induced changes in central serotonergic neurons.
Sinoaortic denervation in rats induced changes in endogenous levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in brain areas. The midbrain showed a sustained increase for 7 days after the operation, while in pons and medulla oblongata a marked rise was only observed during the first 24 h. No changes were obtained in spinal cord. It is thought that the changes in serotonergic activity described could be related to the neurogenic hypertension induced by sinoaortic denervation.
D000818:Animals; D001794:Blood Pressure; D001923:Brain Chemistry; D002490:Central Nervous System / Q000032:analysis*; D003714:Denervation; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D009474:Neurons / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000032:analysis*; D012850:Sinus of Valsalva / Q000294:innervation*; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid