Unchanged antigenic properties of a nuclear non-histone protein during phylogenesis.
The phyletic distribution of Sm antigen in eukaryotes has been investigated by means of immuno-chemical techniques. This nuclear antigen, which is an acidic glycoprotein of about 7S with DNA binding ability, is present in all organisms examined. Such evidence suggests a very slow evolutionary rate for at least the antigenic determinant(s) of the Sm antigen.
D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000276:immunology; D000939:Epitopes / Q000235:genetics*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera; D007668:Kidney / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051379:Mice; D010802:Phylogeny
D002868:Chromosomal Proteins, Non-Histone; D000939:Epitopes; D007106:Immune Sera