[Toxic, anaphylactoid, and sensitizing properties of mercaptoquinolinates, metals of the 8th and 3d group].
A study was made of sensitizing, toxic and anaphylactoid action of eitht compounds of metals belonging to groups VIII and III of the periodic system. It was established that the activity depends on the nature of the central atom in the electronic structure of a complex salt ligand. The mechanism of histamine release was shown to be similar to that of specific antigen and to be related to preservation of the respiratory processes, of the microtubular and cell cyclic nucleotide systems. The sensitizing action of the compounds was shown by the reactions of the immediate and delayed types. Moreover, its realization did not require the presence of high molecular carriers, thus indicating that the latter is formed in the body.
D000485:Allergens; D000818:Animals; D003035:Cobalt / Q000276:immunology; D005260:Female; D005708:Gallium / Q000276:immunology; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D007204:Indium / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D009532:Nickel / Q000276:immunology; D009942:Organometallic Compounds / Q000276:immunology* / Q000633:toxicity; D010101:Oxygen Consumption / Q000187:drug effects; D010165:Palladium / Q000276:immunology; D010984:Platinum / Q000276:immunology; D011725:Pyridines / Q000276:immunology*; D011805:Quinolinic Acids / Q000276:immunology* / Q000633:toxicity; D013438:Sulfhydryl Compounds / Q000276:immunology* / Q000633:toxicity; D013793:Thallium / Q000276:immunology
D000485:Allergens; D009942:Organometallic Compounds; D011725:Pyridines; D011805:Quinolinic Acids; D013438:Sulfhydryl Compounds; D007204:Indium; D003035:Cobalt; D010984:Platinum; D010165:Palladium; D009532:Nickel; D013793:Thallium; D005708:Gallium
Toksicheskie, anafilaktoidnye i sensibiliziruiushchie svoĭstva merkaptokhinolinatov metallov VIII i III grupp.