6-sulphanilamidoindazole arthritis of rats: relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor.
During 6-sulphanilamidoindazole (6-SAI) arthritis a significant increase of serum levels of the protease inhibitor alpha 2 macroglobulin (= alpha 2 acute phase globulin) and of Darcy's glycoprotein was found, whereas the content of female specific protein and of sulfhydryl groups was proved to be significantly decreased. Intravenous administration of 5 mg/kg soybean trypsin inhibitor, twice daily for 4 days, was without any inhibitory effect on paw swelling in 6-SAI arthritis but it caused increased serum levels of alpha 2 macroglobulin and Darcy's glycoprotein. Thus, spontaneous remission of 6-SAI arthritis occurring, despite continued administration of 6-SAI, seems hardly likely to be caused by acute-phase reactants, e.g. via protease inhibition. Evidence is presented which shows that spontaneous remission of 6-SAI arthritis could be due to local processes.
D000818:Animals; D001168:Arthritis / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D007191:Indazoles; D008297:Male; D051381:Rats; D012075:Remission, Spontaneous; D013424:Sulfanilamides; D013997:Time Factors; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D006023:Glycoproteins; D007191:Indazoles; D013424:Sulfanilamides; D014361:Trypsin Inhibitors; D000511:alpha-Macroglobulins; C009347:6-sulfanilamidoindazole