title: [57Co-bleomycin kinetics after local and systemic administration].
abstract: Using a mouse tumor model, an attempt was made to determine whether demonstrable differences could be established for the excretion and organ distribution of labeled bleomycin, whereby the tumor and local lymph node concentration were given special consideration. No significant differences could be established for the excretory behavior with different methods of application (i.t., i.v.). Organ distribution studies however showed that the blood and organ load after intravenous administration of 57Co bleomycin was higher and the tumor concentration significantly lower than after injection directly into the tumor. The lower organ load following injection directly into the tumor was investigated with a toxicity test.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D051379:Mice; D009062:Mouth Neoplasms / Q000188:drug therapy*; D014018:Tissue Distribution
chemical_list: D001761:Bleomycin
vernacular_title: 57Co-Bleomycinkinetik nach lokaler und systemischer Applikation.