Electrophoretically pure mouse interferon exerts multiple biological effects.
Electrophoretically pure (EP) mouse interferon (IF), was examined for a number of biological effects of previously ascribed to crude or partially purified interferon preparations. The following effects were observed: inhibition of antibody formation in vitro; inhibition or enhancement of sensitization to sheep erythrocytes in the mouse, depending on time of administration of IF, and dosage of antigen; inhibition of the expression of delayed type hypersensitivity in vivo; enhancement of natural killer cell activity in vitro and in vivo; inhibition of mouse tumor cells multiplication in vitro; inhibition of the growth of a transplantable tumor in mice. EP mouse IF had a very pronounced priming effect but had no blocking activity.
D000818:Animals; D000917:Antibody Formation; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002478:Cells, Cultured; D005260:Female; D007111:Immunity, Cellular; D007372:Interferons / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains
D007372:Interferons