On the synthesis of alpha-fetoprotein during liver carcinogenesis by N-2-fluorenylacetamide and its relationships with the intracellular localization of the carcinogen.
Adult female Sprague-Dawley rats fed with 0.06% N-2-fluorenylacetamide presented an augmentation of plasma alpha-fetoprotein 2 days after the beginning of the experiment. This very early synthesis of alpha-fetoprotein was concomitant with the penetration of N-2-fluorenylacetamide detected by fluorescence microscopy, in the cytoplasm of the hepatocytes.
D015073:2-Acetylaminofluorene / Q000032:analysis; D000818:Animals; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000032:analysis / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D000509:alpha-Fetoproteins / Q000032:analysis / Q000096:biosynthesis*
D000509:alpha-Fetoproteins; D015073:2-Acetylaminofluorene