Cytotoxic activity of unsaturated fatty acids to lymphocytes.
Cytotoxic activities of unsaturated fatty acids against lymphocytes were studied by demonstrating the inhibition of RNA synthetic activity of incubated lymphocytes. In general, the cytotoxic activity of fatty acids increases with decreasing number of carbon atoms and increasing number of double bonds. An empirical formula predicting the degree of impairment of lymphocytes by various fatty acids was proposed. Furthermore, protective effects of serum on cytotoxic actions of unsaturated fatty acids to lymphocytes were studied and the significance of these findings was discussed.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001769:Blood; D003603:Cytotoxins / Q000494:pharmacology; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology; D008042:Linolenic Acids / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010169:Palmitic Acids / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013329:Structure-Activity Relationship
D001095:Arachidonic Acids; D003603:Cytotoxins; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D008042:Linolenic Acids; D010169:Palmitic Acids; C008757:palmitoleic acid; D016718:Arachidonic Acid; D012313:RNA; D019787:Linoleic Acid