title: [Endolymphatic use of solutions of alkylating substances in a mixture with iodolipol in malignant neoplasms].
abstract: The results of endolymphatic chemotherapy and lymphography in 57 cases of different malignant neoplasms in the lymphatic system are presented. Procedures for making alcohol-oil solution of benzo-TEP, ether-oil solution of tio-TEP and alcohol-oil emulsion of cyclophosphamide are discussed and the clinical evaluation of the results of their application is given. The therapeutic effect of endolymphatic infusions of the mixtures of alkylating agents and iodolipol was assessed on the basis of clinical, histological and radiological examination of malignant lesions of lymph nodes. It is shown that the efficacy of endolymphatic chemotherapy is determined by the susceptibility of neoplasms to antitumor drugs and the availability of the latter at lymph node metastases.
mesh_terms: D000477:Alkylating Agents / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007272:Injections, Intralymphatic; D007459:Iodized Oil / Q000008:administration & dosage*; D008207:Lymphatic Metastasis; D008220:Lymphography / Q000379:methods; D008297:Male; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D012996:Solutions; D013852:Thiotepa / Q000008:administration & dosage; D013997:Time Factors; D013721:Triethylenephosphoramide / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D000477:Alkylating Agents; D012996:Solutions; C000136:benzo-tepa; D007459:Iodized Oil; D003520:Cyclophosphamide; D013852:Thiotepa; D013721:Triethylenephosphoramide
vernacular_title: Ob éndolimfaticheskom primenenii rastvorov alkiliruiushchikh veshchestv v smesi s ĭodolipolom pri zlokachestvennykh novoobrazovaniiakh.