Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats.
Goat leukoencephalitis-arthritis virus (GLV) has the density of a retrovirus in sucrose and contains an endogenous RNA-dependent DNA polymerase (reverse transcriptase). The virion reverse transcriptase utilizes the synthetic RNA template poly(rA). (dT)12 but not the synthetic DNA template poly(dA). (dT)12. A high mol. wt. RNA similar in size to visna virus RNA was isolated from 3H-uridine-labelled virions. The major structural protein of GLV has the same mol. wt. as that of visna virus. From these data the GLV appears to be a retrovirus.
D000820:Animal Diseases / Q000382:microbiology*; D000818:Animals; D001170:Arthritis, Infectious / Q000382:microbiology* / Q000662:veterinary; D002499:Centrifugation, Density Gradient; D004660:Encephalitis / Q000382:microbiology / Q000662:veterinary; D006041:Goats; D012367:RNA, Viral / Q000302:isolation & purification; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012190:Retroviridae / Q000032:analysis*; D014764:Viral Proteins / Q000032:analysis
D012367:RNA, Viral; D014764:Viral Proteins; D012194:RNA-Directed DNA Polymerase