[Increase in the concentration of alpha-fetoprotein in the blood of mice following a single dose of cyclophosphane].
Activation of extramedullar hemopoiesis in the liver together with an appreciable elevation of the alpha-fetoprotein (alpha-FP) level in the blood were observed in CBA, C3H/HeJ, DD, C57BL/6 and CC57BR/Mv mice after a single injection of cyclophosphane in a dose of 200 mg/kg bw. The alpha-FP concentration reached maximum days 2-4 after cyclophosphane administration, amounting of 290-560 ng/ml which surpasses 2-5-fold the basal level of the protein. In mice with an earlier serum alpha-FP elevation (CBA, C3H/HeJ and DD), the liver hemopoiesis also started earlier than in those with a delayed alpha-FP maximum (C57BL/6 and CC57BR/Mv).
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins; D003520:Cyclophosphamide
Uvelichenie kontsentratsii alpha-fetoproteina v krovi mysheĭ posle odnokratnogo vvedeniia tsiklofosfana.