[Studies on the effects of a modified immunoglobulin and beta-lactam antibiotics in the experimental mouse septicemia (author's transl)].
A new gamma-globulin preparation obtained by partial enzymatic cleavage of Fc-regions (Gamma-Venin), was effective in i.v. monotherapy in mice, infected with Streptococcus Aronson B, Pneumococcus mucosus and Salmonella typhimurium. These septicemias are characterized by protracted mortality. There was no measurable effect of the gamma-globulin preparation monotherapy in infections with acute course (Staphylococcus aureus 108, E. coli 078). But in all five experimental septicemias the additional administration of the gamma-globulin formulation enhanced the effectivity of cefotaxime or ampicillin. In those animals both antibiotics were effective in lower doses than in animals having obtained only chemotherapy.
D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002439:Cefotaxime / Q000627:therapeutic use; D051379:Mice; D018805:Sepsis / Q000188:drug therapy*; D013997:Time Factors; D047090:beta-Lactams / Q000627:therapeutic use; D005719:gamma-Globulins / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D005719:gamma-Globulins; C031151:pepsinated immunoglobulin G; D000667:Ampicillin; D002439:Cefotaxime
Untersuchungen zur Wirkung von einem modifizierten Immunoglobulin und beta-Laktam-Antibiotika in der experimentellen Mäuse-Septikämie.