[Conditions for the appearance of parafollicular tumors in the thyroid gland of rats treated with thiamazole].
When rats are treated by an antithyroid drug as the thiamazole, an hyperplasia of the parafollicular thyroideal cells can occur during the treatment, as shown in our previous works, or not, as in the present experiment. This difference depends on the dose of drug used, but it both cases parafollicular tumours never appear during this treatment. Whatever was the initial reaction of the parafollicular cells during the treatment, an important hyperplasia of these cells always expands after its stop and is frequently followed by the development of parafollicular tumours. Then, the initial hyperplasia sometimes obtained is not prerequisite for the formation of neoplasm. The mechanism of tumoral formation must be investigated in the disorders which follow the stop of the treatment.
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology*; D006965:Hyperplasia / Q000139:chemically induced; D008297:Male; D008713:Methimazole / Q000494:pharmacology*; D051381:Rats; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D013956:Antithyroid Agents; D008713:Methimazole
Sur les conditions d'apparition des tumeurs parafolliculaires de la thyroïde du rat traité par le thiamazole.