title: [Retrograde axonal transport and neurotransmitter specificity].
abstract: The hypothesis on transmitter specific, retrograde labeling of neuronal pathways and observations relevant to this hypothesis are discussed. After injection of (3H)-glycine into the pigeon optic tectum fast labeling of intrinsic elements in a restricted part of the subtectal n. isthmi, pars parvocellularis (Ipc), is found - strongly suggesting a rapid retrograde migration of radioactivity in neurons of the glycinergic Ipc-tectal pathway. Labeling of neuronal perikarya in the substantia nigra, in cell groups A8 and A10 and in the n. raphé dorsalis after (3H)-dopamine- and (3H)-serotonin-injection, however in the cortex and in the thalamus after (3H)-D-aspartate-injection into the rat caudoputamen and in the n. raphé dorsalis after (3H)-serotonin-injection but in the caudoputamen after (3H)-GABA-injection into the substantia nigra - all these patterns indicate a retrograde labeling with a certain - partly transmitter specific - selectivity in the pathways concerned. Transmitter related, retrograde transport may become a useful neuro-anatomical method. The cell biology and a possible biological function of the phenomenon remain to be investigated.
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001370:Axonal Transport; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D010856:Columbidae; D004298:Dopamine / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D008854:Microscopy, Electron; D009434:Neural Pathways / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011849:Radioactive Tracers; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D011849:Radioactive Tracers; D001224:Aspartic Acid; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D005998:Glycine; D004298:Dopamine
vernacular_title: Retrograder axonaler Transport und neuronale Transmittorspezifitiät.