[Serum concentration and AV-conduction time in oral treatment with propafenone during a several-days period (author's transl)].
In 6 patients with stable cardiac dysrhythmias (ectopic beats) an oral dose of 300 mg propafenone was given in eight-hour intervals for 4-6 days. A significant correlation between serum concentration and prolongation of PQ-time interval was found. Therefore the changes of PQ-time interval can be used for the control of dose of propafenone.
D000328:Adult; D000368:Aged; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011405:Propafenone; D011427:Propiophenones / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
D011427:Propiophenones; D011405:Propafenone
Serumnkonzentration und AV-Uberleitungszeit unter mehrtägiger oraler Behandlung mit Propafenon.