The influence of lanthanons on morphology and function of rat exocrine pancreas in vivo.
The intravenously administered light lanthanon praseodymium selectively destroys the Golgi complex of rat exocrine pancreas. This effect impairs the normal secretion of proteolytic enzymes which manifests in a reduced output of amylase and trypsin from rat pancreas and a decrease of the basal level of amylase in serum after pilocarpine stimulation.
D000681:Amylases / Q000097:blood / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors; D005260:Female; D006056:Golgi Apparatus / Q000648:ultrastructure; D008854:Microscopy, Electron; D010179:Pancreas / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D010862:Pilocarpine; D011221:Praseodymium / Q000494:pharmacology*; D051381:Rats; D014357:Trypsin / Q000378:metabolism
D010862:Pilocarpine; D000681:Amylases; D014357:Trypsin; D011221:Praseodymium; D002118:Calcium