Brain monoamine levels and E1 mouse convulsions.
E1 mice had higher levels of brain dopamine (DA) and serotonin (5-HT) and a lower level of brain norepinephrine (NE) compared with the other strains of inbred mice. In the interictal stage of "stimulated" E1 mouse, the brain DA, NE and 5-HT levels were significantly lower compared with the non-stimulated E1 mouse. The administration of 5-hydroxytryptophan with MK486 markedly depressed the incidence of seizures in the E1 mouse. Evidence of abnormal DA, NE and 5-HT metabolism was found at the development age when the seizures became frequent. These results show that 5-HT may be closely related to the E1 mouse seizure susceptibility.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism; D004149:Dioxoles / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D005071:Evoked Potentials / Q000187:drug effects; D005669:Fusaric Acid / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007980:Levodopa / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D008818:Mice, Neurologic Mutants; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D019805:alpha-Methyltyrosine
D004149:Dioxoles; D008781:Methyltyrosines; D018377:Neurotransmitter Agents; D012701:Serotonin; D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D019805:alpha-Methyltyrosine; D012110:Reserpine; D006916:5-Hydroxytryptophan; C013242:safrazine; D005669:Fusaric Acid; D004298:Dopamine; D009638:Norepinephrine