[Effect of antianginal agents on nicotinamide coenzyme content and NAD-dependent dehydrogenase activity].
Intraperitoneal administration of pituitrin (2 units/kg) decreases the number of oxidized forms of nicotinamide coenzymes in the rat myocardium and raises the level of reduced forms and LDH activity. Nitroglycerin (1 mg/kg) prevents pituitrin-induced changes in the content of coenzymes and in LDH activity.
D000818:Animals; D003327:Coronary Disease / Q000139:chemically induced; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology; D009243:NAD / Q000032:analysis*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009249:NADP / Q000032:analysis*; D005996:Nitroglycerin / Q000494:pharmacology*; D010208:Papaverine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010909:Pituitary Hormones, Posterior / Q000494:pharmacology; D051381:Rats
D010909:Pituitary Hormones, Posterior; D009243:NAD; D009249:NADP; C005317:drotaverin; D010208:Papaverine; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases; D005996:Nitroglycerin
Vliianie antianginal'nykh sredstv na soderzhanie nikotinamidnykh kofermentov i aktivnost' NAD-zavisimykh degidrogenaz.