Recurrent hemolytic uremic syndrome during oral contraception.
A 23-year-old multiparous normotensive woman developed a hemolytic uremic syndrome (HUS) five months postpartum, and four months after starting estro-progestogen contraception. Eight years later a recurrence appeared, five years after a successful cadaver kidney transplantation and ten months after resumption of the estro-progestogen intake. In the interval a pure progestogen contraceptive was prescribed without problems. This observation is consistent with the hypothesis that HUS can be triggered by oral estrogen intake in predisposed individuals.
D000328:Adult; D000368:Aged; D002715:Chlormadinone Acetate / Q000009:adverse effects*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003279:Contraceptives, Oral, Sequential / Q000009:adverse effects*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000139:chemically induced*; D006801:Humans; D006973:Hypertension / Q000150:complications; D016030:Kidney Transplantation; D008656:Mestranol / Q000009:adverse effects*; D008875:Middle Aged; D012008:Recurrence
D003276:Contraceptives, Oral; D003279:Contraceptives, Oral, Sequential; D002715:Chlormadinone Acetate; D008656:Mestranol