title: Studies on the plasma membrane of normal and psoriatic keratinocytes. 5. Lectin binding.
abstract: The glycocalyx of epidermal keratinocytes from psoriatic patients has been investigated by means of lectins. Striking changes were found in the levels of glucose and/or mannose (concanavalin A) and of N-acetylglucosamine and/or sialic acid (wheat germ agglutinin) on the surface of cells from the psoriatic lesion. Smaller but significant changes were seen in the clinically uninvolved epidermis of the patient. A marked increase in the affinity of the cell surface for Ulex europus agglutinin (fucose-specific) confirms our previous reports of structural alterations in fucose-containing oligosaccharides in psoriasis.
mesh_terms: D001665:Binding Sites; D050260:Carbohydrate Metabolism; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D007633:Keratins / Q000378:metabolism; D037102:Lectins / Q000378:metabolism*; D011565:Psoriasis / Q000378:metabolism*; D012867:Skin / Q000166:cytology / Q000378:metabolism*
chemical_list: D037102:Lectins; D007633:Keratins