Possible role of histamine in rheumatoid arthritis. Treatment with cimetidine and mepyramine.
Basophilocytes from patients with rheumatoid arthritis (RA) responded to leukocyte nuclei from normal persons with histamine release; a similar histamine release induced by the nuclear components RNA and DNA has been demonstrated previously. A role of histamine in RA is also supported by the findings of clinical improvement during treatment with H1 and H2 antihistamines in six of 12 patients with RA in active phase, whereas four showed definite deterioration.
D000293:Adolescent; D000328:Adult; D000631:Aminopyridines / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D002927:Cimetidine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006636:Histamine Release; D006801:Humans; D008297:Male; D008875:Middle Aged; D011738:Pyrilamine / Q000627:therapeutic use*
D000631:Aminopyridines; D006146:Guanidines; D006634:Histamine H1 Antagonists; D002927:Cimetidine; D011738:Pyrilamine