Suriclone, a new anxiolytic of the cyclopyrrolone family: evidence for possible interference with GABAergic systems.
The action of suriclone (R.P. 31,264), a new non-benzodiazepine compound of the cyclopyrrolone family with clinical anxiolytic activity was examined using biochemical and electrophysiological models supposed to be capable of revealing central GABAergic activity. Suriclone, which does not act directly on the gamma-aminobutyric acid (GABA) receptor (muscimol binding assay), markedly reduced the increase of striatal HVA level induced in the rat by a neuroleptic and decreased the cerebellar vermis cGMP content. Moreover, in the cat, suriclone was able to enhance dorsal root potential amplitude which reflects an increase of the presynaptic inhibition. In view of these results, a central GABAergic mechanism of action may be proposed for suriclone.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D002415:Cats; D002531:Cerebellum / Q000378:metabolism; D002707:Chlordiazepoxide / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects; D006152:Cyclic GMP / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D006719:Homovanillic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D009118:Muscimol / Q000378:metabolism; D009287:Naphthyridines; D009567:Nitrazepam / Q000494:pharmacology; D010640:Phenothiazines / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects; D013457:Sulfur Compounds; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D009287:Naphthyridines; D010640:Phenothiazines; D010879:Piperazines; D013457:Sulfur Compounds; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D002707:Chlordiazepoxide; D009567:Nitrazepam; D006152:Cyclic GMP; C037283:suriclone; D003975:Diazepam; D006719:Homovanillic Acid