Histamine releasing and histamine binding action of platinum and palladium compounds.
Platinum and palladium salts were shown to possess either histamine releasing or histamine binding properties. Both these effects were dependent on chemical structures of the tested compounds and might be drawn up in the following sequences; Pd greater than Pt, PtIV greater than PtII, NO2 greater than F greater than Cl greater than SCN greater than J, trans greater than cis. One of the possible mechanisms of anti-tumoral effect of platinum and palladium salts might be their marked histamine binding activity.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects*; D010165:Palladium / Q000378:metabolism / Q000494:pharmacology*; D010984:Platinum / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
D010984:Platinum; D010165:Palladium; D006632:Histamine