Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3.
A murine monoclonal antibody directed against a human B cell surface antigen with the characteristics of HLA-DR is described. The antigen detected is tightly linked to HLA and is correlated with the alloantigen HLA-Dw/DR3. Reactivity with a fraction of Dw/DRw6 cells is also observed. The determinant recognized by this antibody has been shown to be present on the smaller molecular weight beta subunit of the HLA-DR antigen.
D000818:Animals; D000911:Antibodies, Monoclonal; D015478:Antigens, Heterophile / Q000276:immunology; D055598:Chemical Phenomena; D002621:Chemistry; D000939:Epitopes; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D008545:Melanoma / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight
D000911:Antibodies, Monoclonal; D015478:Antigens, Heterophile; D000939:Epitopes; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D007126:Immunoglobulin Allotypes