A possible cytochrome P-450-mediated N-oxidation of diethylcarbamazine.
There was a marked sex difference in the N-oxidation of diethylcarbamazine (DEC) in the rat. In 72 h, 41 and 20% of the administered DEC was excreted in urine as the N-oxide in male and female rats respectively. Safrole, metyrapone and ethanol inhibited this N-oxide formation in male rats by 71, 37 and 44% whereas in female rats the values were 20, 25 and 0% respectively. Phenobarbitone and anthracene enhanced N-oxide formation in male rats by 17 and 20% and in female rats by 50 and 90% respectively, but the amount of the N-oxide formed was more in the males. The result suggests a possible involvement of a sub-population of cytochrome P-450 isozyme (which is more in male rats) in the N-oxidation of DEC.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004049:Diethylcarbamazine / Q000378:metabolism*; D005260:Female; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D004049:Diethylcarbamazine