Pharmacological comparison of bPTH-(1-34) and other hypotensive peptides in the dog.
The purpose of the present study was to compare the potency, effectiveness and duration of action of synthetic bPTH-(1-34) with those of other known hypotensive peptides in the anesthetized dog. Of sixteen peptides tested in the present study only 8 were demonstrated to possess hypotensive activity. While bPTh-(1-34) was one of the least potent of the hypotensive peptides, it was equal to or greater than the other peptides in terms of effectiveness and duration of action. Of all the peptides studied, substance P and eledosin were the most potent in terms of their hypotensive action. It is suggested that perhaps substance P and eledoisin might act at a different site or through different mechanisms than do vasoactive intestinal peptide (V.I.P.), corticotropin inhibiting peptide (C.I.P.), neurotensin, xenopsin, bradykinin and bPTH-(1-34).
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D004285:Dogs; D004600:Eledoisin / Q000494:pharmacology; D005260:Female; D008297:Male; D009496:Neurotensin / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D013373:Substance P / Q000494:pharmacology; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology; D029867:Xenopus Proteins
D000959:Antihypertensive Agents; D009842:Oligopeptides; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D010455:Peptides; D029867:Xenopus Proteins; C025076:parathyroid hormone (1-34), bovine; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin; C016832:xenopsin; C026034:ACTH (7-38); D004600:Eledoisin; D000324:Adrenocorticotropic Hormone; D001920:Bradykinin