title: Beta-adrenoceptor blocker toxicity: clinical features and therapy.
abstract: Therapy for severe beta-blocker poisoning should be based upon careful supportive therapy. In most cases of poisoning, elimination techniques cannot be expected to remove significant amounts of the drug. Inotropic drugs such as isoproterenol, prenalterol and glucagon in adequate (i.e. large) doses may be necessary to counteract cardiac failure.
mesh_terms: D000042:Absorption; D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000097:blood / Q000378:metabolism / Q000506:poisoning; D000328:Adult; D000368:Aged; D001682:Biological Availability; D002316:Cardiotonic Agents / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced; D005260:Female; D005751:Gastric Lavage; D006207:Half-Life; D006339:Heart Rate; D006464:Hemoperfusion; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced; D012737:Sex Factors; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D013406:Suicide, Attempted; D013548:Sweden; D014018:Tissue Distribution
chemical_list: D000319:Adrenergic beta-Antagonists; D002316:Cardiotonic Agents