Interferon stabilization and enhancement by rare earth salts.
The addition of salts of the rare earth elements (lanthanides) enhances by a factor of two or more the initial activity of human fibroblast, leukocyte and immune interferons as well as mouse L-cell interferon. Furthermore, the salts of the lanthanides (0.01 to 0.002 M) preserve the activity of human fibroblast interferon not only after 4 days of heating at 37 degrees C but also after exposure to severe shearing forces; human leukocyte interferon was stabilized to a lesser degree, albeit significantly.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005347:Fibroblasts; D006358:Hot Temperature; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D007962:Leukocytes; D008674:Metals, Rare Earth / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013314:Stress, Mechanical
D008674:Metals, Rare Earth; D007372:Interferons