Seizures induced by abrupt discontinuation of alprazolam.
Two patients had grand mal seizures following abrupt discontinuation of short-term treatment with alprazolam. Alprazolam's pharmacokinetic and clinical properties are discussed in relation to withdrawal reactions.
D000328:Adult; D000525:Alprazolam; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000378:metabolism; D001569:Benzodiazepines / Q000009:adverse effects* / Q000378:metabolism; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D000525:Alprazolam