Production of anti-self H-2 antibodies by hybrid mice immune to a viral tumour.
During the course of immunization of hybrid mice (genotype H-2b/k) with a parental Abelson virus-induced lymphoma (genotype H-2b/b), antibodies were produced to the H-2Kb or H-2Db antigens of the immunizing cells. Such 'anti-self H-2' antibodies demonstrate the existence of autoreactive B-cell clones in hybrid mice, and pose intriguing questions for the nature of self-tolerance.
D000011:Abelson murine leukemia virus / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D000939:Epitopes; D006183:H-2 Antigens; D007108:Immune Tolerance; D007114:Immunization; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D009368:Neoplasm Transplantation; D013154:Spleen / Q000276:immunology
D001323:Autoantibodies; D000939:Epitopes; D006183:H-2 Antigens