Effect of central prostaglandins on carrageenan-induced pedal oedema in rats.
The possible modulatory effect of central prostaglandins (PGs) on carrageenan-induced pedal inflammation, was investigated in rats. Intracerebroventricularly (i.c.v.) administered arachidonic acid, the PG precursor, produced a statistically insignificant increase in the inflammatory response, though PG synthesis inhibitors, administered by the same route, markedly attenuated the oedema. Centrally administered PGE2 had a significant pro-inflammatory effect, whereas PGF2 alpha exerted an anti-inflammatory action. The results indicate that central PGs may modulate peripheral inflammation and that, at least partly, the anti-inflammatory activity of PG synthesis-inhibiting non-steroidal anti-inflammatory agents may involve central PGs, as has been proposed for their analgesic effect.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D002351:Carrageenan; D004008:Diclofenac / Q000494:pharmacology; D015237:Dinoprost; D015232:Dinoprostone; D004487:Edema / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats
D001095:Arachidonic Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D004008:Diclofenac; D016718:Arachidonic Acid; D002351:Carrageenan; D015237:Dinoprost; D015232:Dinoprostone; D001241:Aspirin