[Effect of hydrocortisone on gamma-glutamyl transferase activity of the rat liver and hepatoma].
The activity of membrane-bound enzyme gamma-glutamyl transferase (GGT) is twice increased in the liver of normal and tumour-bearing rats after hydrocortisone intramuscular injections (10 mg/kg body weight). At the same time GGT activity is not increased in serum and hepatoma G-27. The glutathione-reductase activity and contents of G-SH and G-S-S-G in the rat liver and hepatoma are not altered by Hydrocortisone action at the different means of hormone administration. Effect of hydrocortisone is studied also on the GGT activity in the liver of newborn rats. The stimulation of GGT activity by hydrocortisone is probably due to an induction of protein synthesis.
D000818:Animals; D000831:Animals, Newborn; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005260:Female; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000201:enzymology*; D008297:Male; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism*
D005980:Glutathione Reductase; D005723:gamma-Glutamyltransferase; D006854:Hydrocortisone; D004121:Dimethyl Sulfoxide
Vliianie gidrokortizona na aktivnost' gamma-glutamiltransferazy pecheni i gepatomy krys.