Inhibition of neutrophil-mediated cytotoxicity by alpha 2 macroglobulin.
Highly purified human alpha 2 macroglobulin (1.2--10 mg/ml) was shown to inhibit phytohemagglutinin-induced or antibody-induced lysis of chicken erythrocytes by polymorphonuclear neutrophils. Inhibition was not associated with impaired contact between effector and target cells but rather with the antiprotease activity of alpha 2 macroglobulin.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D037102:Lectins; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D000511:alpha-Macroglobulins / Q000494:pharmacology*
D037102:Lectins; D000511:alpha-Macroglobulins