Antiviral activity of Norakin (triperiden) and related anticholinergic antiparkinsonism drugs.
In view of the coincidence of antiviral and antiparkinsonism activities of amantadine four antiparkinsonism drugs, NorakinR (triperiden), ParkopanR (trihexyphenidyl), AntiparkinR (diethylbenzhydramine) and AkinetonR (biperiden) were tested for antiviral activity in various virus-cell systems. Norakin inhibited the replication of influenza A viruses in chick embryo fibroblast, MDCK and Ehrlich ascites tumour cells. It also inhibited the replication of measles virus in Vero cells, 50% inhibitory concentrations being 2-6 micrograms/ml. The drugs were also active against influenza B virus. Several representatives of other virus families, e.g. vaccinia, vesicular stomatitis, polio type 1 and herpes simplex type 1 viruses were insensitive to the compounds.
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D009980:Influenza A virus / Q000254:growth & development; D008459:Measles virus / Q000254:growth & development; D010252:Paramyxoviridae / Q000254:growth & development; D017955:Poliovirus / Q000254:growth & development; D013329:Structure-Activity Relationship; D014282:Trihexyphenidyl / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000978:Antiparkinson Agents; D014282:Trihexyphenidyl