The absence of substance P from guinea pig auditory structures.
The following auditory structures were examined for Substance-P-Containing cells and fibres using a monoclonal antibody: organ of Corti, spiral ganglion, auditory nerve, cochlear nucleus. No substance P was detected in any of these structures. Giving due consideration to the sensitivity and specificity of this method of detection, it was concluded that Substance P has no function in the lower auditory system of the guinea pig.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D003051:Cochlea / Q000032:analysis*; D003056:Cochlear Nerve / Q000032:analysis; D006168:Guinea Pigs; D009925:Organ of Corti / Q000032:analysis; D013136:Spiral Ganglion / Q000032:analysis; D013373:Substance P / Q000032:analysis*; D000159:Vestibulocochlear Nerve / Q000032:analysis*
D000911:Antibodies, Monoclonal; D013373:Substance P