The occurrence of the Leloir pathway in non-pathogenic mycobacteria.
It has been found that saprophytic strains of mycobacteria can utilize D-galactose via the Leloir pathway which involves galactokinase, galactose-1-phosphate uridyl transferase and UDP-galactose-4-epimerase. The resulted glucose-1-phosphate is further converted by phosphoglucomutase to glucose-6-phosphate and the latter catabolized in glycolitic cycle to pyruvate. The particular enzymes of the galactose pathway have been fully separated by chromatography on a DEAE-cellulose column and some of them partially characterized.
D002238:Carbohydrate Epimerases / Q000378:metabolism*; D005686:Galactokinase / Q000302:isolation & purification / Q000378:metabolism*; D005690:Galactose / Q000378:metabolism*; D007700:Kinetics; D009161:Mycobacterium / Q000201:enzymology*; D009713:Nucleotidyltransferases / Q000378:metabolism*; D013045:Species Specificity; D014534:UDPglucose 4-Epimerase / Q000302:isolation & purification / Q000378:metabolism*; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase / Q000302:isolation & purification / Q000378:metabolism*
D005686:Galactokinase; D009713:Nucleotidyltransferases; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase; D002238:Carbohydrate Epimerases; D014534:UDPglucose 4-Epimerase; D005690:Galactose