[Comparative study of substance P and its fragments: analgesic properties, effect on behavior and monoaminergic processes].
The effect of substance P (SP) and of its fragments 5-11, 8-11, 9-11, 10-11 administered into the brain ventricles in doses of 5, 25 and 50 nM on the behavior and content of biogenic monoamines of the rat brain was studied. The analgetic properties of the substances under consideration and those of fragment SP 10-11 in doses of 5, 25, 50 and 100 nM were also subjected to examination. It was found that SP and fragment 5-11 stimulate and enhance the locomotor activity in rats, while fragments 8-11 and 9-11 provoke hypoactivity. The substances under study increase the serotonin and dopamine turnover, whereas SP and fragment 8-11 lower the serotonin content as well. After administration of SP and fragment 5-11 analgesia was seen to transform to hyperalgesia depending on the dose. Fragments 8-11 and 9-11 produce analgetic effect. It is suggested that both SP fragments and the whole SP molecule can influence the neurochemical process that regulate behavior and pain perception.
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000032:analysis; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D013373:Substance P / Q000494:pharmacology*
D000700:Analgesics; D001679:Biogenic Amines; D010446:Peptide Fragments; D012701:Serotonin; D013373:Substance P; D004298:Dopamine; D009638:Norepinephrine
Sravnitel'noe izuchenie veshchestva P i ego fragmentov: anal'geticheskie svoĭstva, vliianie na povedenie i monoaminergicheskie protsessy.