[Changes of neurotransmitter, lipid peroxide and their metabolic related enzyme activities in the brain of rats exposed to noise and vitamin E].
Effects of noise on locomotor activities were analysed in rat. In addition, changes in lipid peroxide (LPX), their metabolic related enzyme activities, and neurotransmitter in the rat brain due to noise exposure and the effects of vitamin E on the rats were studied. The results obtained were as follows: After white noise exposure of 95 dB (A), the locomotor activities of rat increased. But 3 weeks after noise exposure, the activities began to decrease. LPX and glutathione peroxidase (GSH-Px) activities in hypothalamus and cortex increased at the 14th day after noise exposure or at the 21st day after noise exposure. Superoxide dismutase (SOD) activities increased in hippocampus at the 4th day after noise exposure, and decreased in midbrain and thalamus at the 14th day and the 21th day after noise exposure. Norepinephrine (NE) increased in hypothalamus at the 1st day, the 2nd day and the 7th day after noise exposure, and increased in striatum at the 7th day after noise exposure, in cortex at the 4th day and the 7th day after exposure. At the 14th day after noise exposure, NE decreased in cerebellum, in medulla and pons, in midbrain and thalamus, and in cortex. In cortex NE also decreased at the 21st day after noise exposure. Serotonin increased in hypothalamus and in midbrain and thalamus at the 1st and 4th day after noise exposure, and increased in striatum at the 7th day after noise exposure. Decrease in serotonin was observed in cerebellum at the 14th day after noise exposure. Vitamin E decreased LPX in rat brain and the liver.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006624:Hippocampus / Q000201:enzymology; D008054:Lipid Peroxides / Q000378:metabolism*; D008124:Locomotion; D008297:Male; D009043:Motor Activity; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009622:Noise; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D008054:Lipid Peroxides; D018377:Neurotransmitter Agents; D014810:Vitamin E; D012701:Serotonin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D009638:Norepinephrine