[Immunoprevention of staphylococcal infections at an industrial enterprise].
The immunogenicity, immunological and epidemiological effectiveness of the subcutaneous, enteral and combined immunizations of the workers at a steel plant with staphylococcal toxoid has been studied. The subcutaneous injection of the adsorbed toxoid in a dose of 0.2 ml by means of the jet injector, model, was accompanied by moderate reactogenicity (the frequency of local reactions was 26.8%, and the frequency of systemic reaction 18%) and produced 4-fold increase in antitoxin titers and 12-fold decrease in the morbidity rate of staphyloccal infection. Enteral immunization in 3 administrations proved to be nonreactogenic and only slightly effective (antitoxin titers increased more than 2-fold, morbidity rate fell 2-fold). Combined immunization (subcutaneous and enteral) with the toxoid, preceded by the injection of gamma globulin, reduced the frequency of reaction 2- to 3-fold and stimulated antitoxin production (the titer increased 8-fold), thus decreasing the morbidity rate of staphylococcal infection 3.1-fold.
D000284:Administration, Oral; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D005334:Fever / Q000209:etiology; D006801:Humans; D007279:Injections, Subcutaneous; D008213:Lymphocyte Activation; D009787:Occupational Medicine; D012871:Skin Diseases / Q000209:etiology; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013208:Staphylococcal Toxoid / Q000008:administration & dosage* / Q000009:adverse effects; D013232:Steel; D005719:gamma-Globulins / Q000008:administration & dosage*
D000907:Antibodies, Bacterial; D013208:Staphylococcal Toxoid; D005719:gamma-Globulins; D013232:Steel
Immunoprofilaktika stafilokokkovykh infektsiĭ na promyshlennom predpriiatii.