Immunochemical properties of Vi antigen from Salmonella typhi Ty2: presence of two antigenic determinants.
Antigen Vi of Salmonella typhi was found to have at least two antigenic determinants. In one of them, O-acetyl moiety played a dominant role. The second antigenic determinant did not involve O-acetyl residues, but both carboxyl and N-acetyl groups were necessary for the antigen-antibody reaction. These results were obtained by performing serological tests with antigen Vi, with its structural analog, polygalacturonic acid, and with the derivatives of both polysaccharides.
D000942:Antigens, Bacterial / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D007106:Immune Sera; D011233:Precipitin Tests; D012485:Salmonella typhi / Q000276:immunology*
D000942:Antigens, Bacterial; D000939:Epitopes; D007106:Immune Sera