title: Hemoglobin Brisbane: beta68 Leu replaced by His. A new high oxygen affinity variant.
abstract: Hemoglobin Brisbane is a new hemoglobin variant which produces a mile erythrocytosis. It is not detectable by electrophoresis at pH 8.6 or by isoelectric focusing but it is mildly unstable and gives a positive result with standard stability tests. The new hemoglobin has increased oxygen affinity and reduced co-operativity with a normal Bohr effect and 2,3-DPG binding. Structural analysis shows that a histidine residue has replaced the leucine normally found at position beta 68 (E12).
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001315:Australia; D004163:Diphosphoglyceric Acids / Q000097:blood; D005260:Female; D005319:Fetal Hemoglobin; D014644:Genetic Variation; D006441:Hemoglobin A; D006455:Hemoglobins, Abnormal; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010455:Peptides; D014357:Trypsin / Q000494:pharmacology
chemical_list: D004163:Diphosphoglyceric Acids; D006455:Hemoglobins, Abnormal; D010455:Peptides; C030901:hemoglobin Brisbane; D006441:Hemoglobin A; D005319:Fetal Hemoglobin; D014357:Trypsin