Adjuvant interferon treatment and the late development of cerebral metastases in a patient with osteosarcoma.
A consecutive series of patients with osteocarcoma have been receiving adjuvant interferon therapy at the Karolinska Hospital in Stockholm. We report here a case of tibial chondroblastic Grade III osteosarcoma, a boy aged 17 years, who received interferon therapy for 15 months and survived more than 5 years. The first sign of tumour spread was multiple cerebral metaseases--an observation suggesting an antitumour effect of human leucocyte interferon on osteosarcoma.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D001859:Bone Neoplasms / Q000473:pathology / Q000628:therapy*; D001932:Brain Neoplasms / Q000556:secondary*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary; D012516:Osteosarcoma / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D013977:Tibia / Q000473:pathology
D000276:Adjuvants, Immunologic; D007372:Interferons