title: Hemoglobin chain recombination and the pattern of composition of hemoglobin S and D in heterozygotes.
abstract: The pattern of composition of hemoglobin in different heterozygotes for S and D hemoglobins is quantitatively accounted for by the relative rates of combination of the different chains alpha + beta A greater than alpha + beta D greatern than alpha + beta S greater than alpha + gamma. It is suggested that the recombination step may be one of the rate-limiting steps in hemoglobin assembly.
mesh_terms: D000328:Adult; D000468:Alkalies / Q000494:pharmacology; D002852:Chromatography, Ion Exchange; D005319:Fetal Hemoglobin / Q000235:genetics; D006207:Half-Life; D006451:Hemoglobin, Sickle / Q000235:genetics*; D006454:Hemoglobins / Q000096:biosynthesis / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D011995:Recombination, Genetic
chemical_list: D000468:Alkalies; D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D005319:Fetal Hemoglobin