[Presence of macromolecular HBe antigen linked to HBs antigen with masked epitopes in the serum of patients actively reproducing hepatitis B virus].
At the onset of hepatitis B and more generally in some other types of this infection implying active replication of hepatitis B virus, HBe Ag is detected in the serum as macromolecular complexes with more or less masked epitopes. At the same time, HBe Ag appears bound to HBs Ag as shown by a radioimmunological assay on solid phase, implying anti-HBs and anti-HBe specificities in the same test.
D000939:Epitopes; D006509:Hepatitis B / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006801:Humans; D046911:Macromolecular Substances; D013861:Thiocyanates / Q000494:pharmacology; D014779:Virus Replication
D000939:Epitopes; D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D046911:Macromolecular Substances; D013861:Thiocyanates
Présence d'antigène HBe macromoléculaire lié à l'antigène HBs avec épitopes masqués, dans le sérum de sujets répliquant activement le virus de l'hépatite B.