Isolation from murine myeloma and leukemia cells of a selective inhibitor of DNA polymerases.
An inhibitor of two ribopolymer-transcribing DNA polymerases can be isolated from MOPC-21 myeloma tumors, from the sera of mice bearing these tumors, or from MCDV-12 ascitic leukemia. The peritoneal fluid of mice bearing the latter neoplasm is also a source of the inhibitor. The inhibitor is a small DNA molecule which displays inhibitory activity in both double- and single-stranded form.
D000818:Animals; D002460:Cell Line; D004258:DNA Polymerase III / Q000037:antagonists & inhibitors; D004273:DNA, Neoplasm / Q000302:isolation & purification / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000201:enzymology*; D051379:Mice; D008928:Mitochondria / Q000201:enzymology; D019384:Nucleic Acid Synthesis Inhibitors; D010954:Plasmacytoma / Q000201:enzymology*; D018894:Reverse Transcriptase Inhibitors; D013379:Substrate Specificity
D004273:DNA, Neoplasm; D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D004258:DNA Polymerase III