title: Multinucleation in response to cytochalasin B: a common feature in several human tumor cell lines.
abstract: Human tumor cell lines derived from melanoma, glioblastoma, and carcinoma of the prostate, bladder, and kidney multinucleated in response to growth in cytochalasin B-supplemented medium, whereas cell lines derived from normal prostate, kidney, skin, lung, and other nonmalignant diseases remained predominantly binucleate under comparable conditions. The multinucleate cytochalasin B phenotype was dissociable from the anchorage-independent phenotype of tumor cells, suggesting that these markers of cellular transformation are under separate control. These results suggest that uncontrolled nuclear division by tumor cells may be a general marker of abnormal growth or regulation.
mesh_terms: D002460:Cell Line; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D003571:Cytochalasin B / Q000494:pharmacology*; D005910:Glioma / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008545:Melanoma / Q000648:ultrastructure; D009369:Neoplasms / Q000503:physiopathology / Q000648:ultrastructure*; D011467:Prostate / Q000648:ultrastructure; D011470:Prostatic Hyperplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000648:ultrastructure; D001749:Urinary Bladder Neoplasms / Q000648:ultrastructure
chemical_list: D003571:Cytochalasin B