Five new Gc variants detected by isoelectric focusing in agarose gel.
Five new genetically determined Gc variants were observed by isoelectric focusing. Seven rare variants 1A4, 1Cl, 1C3, 1C9, 1C11, 2A2, and 2A5 were also found in the material comprising Danish and Swedish paternity cases. All the variants were further analysed by electrophoresis in agarose gel. Two of the new variants had double bands of which the anodal one was susceptible to neuraminidase treatment (Gc 1C13 and 1C14). The three other new variants appeared as a single band, which was unaffected by neuraminidase treatment (Gc 2A9, 2C5, and 2C6). The Gc Ar variant originally detected by electrophoresis was reexamined by isoelectric focusing and named 2C4.
D000328:Adult; D000510:Alpha-Globulins / Q000235:genetics*; D000665:Ampholyte Mixtures; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D004587:Electrophoresis, Agar Gel; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D009439:Neuraminidase / Q000494:pharmacology; D010334:Paternity; D010375:Pedigree; D014809:Vitamin D-Binding Protein
D000510:Alpha-Globulins; D000665:Ampholyte Mixtures; D002352:Carrier Proteins; D014809:Vitamin D-Binding Protein; D009439:Neuraminidase