title: Treatment of carcinoma of the head and neck with combined irradiation and chemotherapy.
abstract: Radiation therapy was combined with simultaneous administration of bleomycin, cyclophosphamide and 5-fluorouracil for the treatment of 33 patients with carcinoma of the head and neck. This combination increased the toxicity to the normal tissue. Complete response was obtained in 46 per cent, partial response in 36 per cent and no response in 18 per cent. Patients with a complete response had a significantly longer survival than patients with a partial or no response. An increased cytotoxicity was noted after the combined treatment when compared with irradiation alone. However, no evidence of an increased therapeutic effect was obtained with the addition of simultaneous chemotherapy to irradiation.
mesh_terms: D001761:Bleomycin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D011379:Prognosis; D011879:Radiotherapy Dosage
chemical_list: D001761:Bleomycin; D003520:Cyclophosphamide; D005472:Fluorouracil