Studies in constitutionally tall adolescents: somatostatin decrease associated with growth hormone increase after TRH injection.
The paradoxical GH response to TRH observed in certain adolescents with constitutional tall stature is associated with a 60% fall in plasma levels of somatostatin. Conversely, those tall subjects who do not show a GH increase after TRH, or during a saline control infusion maintain steady levels of somatostatin in plasma. It is thus hypothesized that the GH release after TRH is due to a decreased inhibitory effect of somatostatin at the pituitary level and that this reduced effect may play an aetiological role in certain children with 'constitutional' tall stature.
D000293:Adolescent; D001827:Body Height; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000097:blood* / Q000503:physiopathology; D013006:Growth Hormone / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D010455:Peptides / Q000097:blood*; D013004:Somatostatin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D010455:Peptides; C029993:somatostatin-like peptides; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone