Effects of testosterone on renal ornithine decarboxylase and kidney function.
Testosterone injection caused a 2,000% increase in renal ornithine decarboxylase activity in intact male mice. A single injection of testosterone produced the same effect as repeated injections. The response was dose-dependent and could be blocked by actinomycin, diaminopropane, and cadaverine. Cycloheximide and putrescine had no inhibitory effect. Renal ODC response to arginine vasopressin was altered after castration; however, urine specific gravity and serum osmolality were unaffected by changes in renal ornithine decarboxylase activity.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000378:metabolism*; D002369:Castration; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000494:pharmacology*
D001127:Arginine Vasopressin; D003609:Dactinomycin; D013739:Testosterone; D003513:Cycloheximide; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase