Toxicology studies of fenbufen.
The acute, subacute, and chronic toxicity of gamma-oxo[1,1'-biphenyl]-4-butanoic acid (fenbufen), a new orally and parenterally effective non-steroidal antiinflammatory, analgesic, and antipyretic agent, was investigated in mice, rats, and dogs. In these studies, the gastrointestinal and renal changes associated with toxic doses of fenbufen resembled those described for this class of drug. In coadministration studies, there were no evidences of specific adverse interactions when fenbufen was given with dicoumarol or with triamcinolone; however, coadministration of acetylsalicylic acid (ASA) and fenbufen resulted in decreased plasma concentrations of fenbufen-related materials and a possible increase in the incidence of gastrointestinal hemorrhages or ulcers.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D001241:Aspirin / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000633:toxicity; D001728:Dicumarol / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D008297:Male; D051379:Mice; D010654:Phenylbutyrates; D011422:Propionates / Q000633:toxicity*; D051381:Rats; D013045:Species Specificity; D013997:Time Factors; D014221:Triamcinolone / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D001713:Biphenyl Compounds; D010654:Phenylbutyrates; D011422:Propionates; D014221:Triamcinolone; D001728:Dicumarol; C010725:fenbufen; D001241:Aspirin