Study of biochemical and hormonal data in idiopathic scoliosis in girls.
Basic cause and factors determining the progression of idiopathic scoliosis are assumed to be multifarious. A deviating growth pattern has also been suspected. The influence of certain bone and growth-stimulating hormones and related biochemical values has been studied in girls with idiopathic scoliosis compared to controls. The mineral content (S-Ca, S-P and S-Alp) did not differ between idiopathic scoliosis and controls. a2-macroglobulin was slightly increased in the scoliotic group in all ages. Morning fast GH and Somatomedin A level in serum were also increased in the scoliotic group. Even a significant increase of 17-oxosteroids are metabolites of androgens in girls. 17-oxosteroids in urine mainly metabolites of cortisol, neither calcitonin or parathyroid hormone, in contrary, did not differ between scoliosis and controls.
D015068:17-Ketosteroids / Q000652:urine; D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008903:Minerals / Q000378:metabolism*; D010710:Phosphates / Q000097:blood; D012600:Scoliosis / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D015068:17-Ketosteroids; D006728:Hormones; D008903:Minerals; D010710:Phosphates; D012709:Serum Albumin; D000511:alpha-Macroglobulins; D013006:Growth Hormone; D003404:Creatinine; D000469:Alkaline Phosphatase; D002118:Calcium; D006854:Hydrocortisone