Antiandrogenic effects of cyproterone acetate and chloromadinone acetate on the rat hypothalamus as revealed by electroencephalographic responses.
Bipolar stainless steel electrodes were implanted stereotaxically into given hypothalamic and cortical regions of the brain of 48 rats. The animals were divided into two groups of equal numbers and the electrical activity of the given regions was recorded electroencephalographically (EEG). The effect of the acute and chronic administration of cyproterone acetate (CPA) or chloromadinone acetate (CHA), in doses inducing sterility, on EEG activity were observed. Apart from slight inhibition in the preoptic region, no appreciable EEG changes were found after CPA, while CHA reduced the discharge frequency in both the preoptic and the posterior hypothalamus. These findings can be attributed to the presence of two different types of androgen receptors in the hypothalamus.
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D002715:Chlormadinone Acetate / Q000494:pharmacology*; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D004569:Electroencephalography; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology; D051381:Rats
D000726:Androgen Antagonists; D003272:Contraceptive Agents, Male; D002715:Chlormadinone Acetate; D017373:Cyproterone Acetate; D003534:Cyproterone