Preparation and characterization of the anti-idiotypic properties of rabbit anti-timothy antigen B helper factor and anti-mouse timothy IgE antisera.
with AgB-primed B or T cells and injected into syngeneic X-irradiated recipients. Anti-THF and anti-Eid purified by an AgB-specific T suppressor factor (TSF) affi-gel adsorbent retain their ability to specifically initiate [3H]-thymidine incorporation of AgB-primed T cells. The data indicate that both anti-THF and anti-Eid recognize unique determinants present on AgB-specific T-helper, T-suppressor and B cells, and suggest that the receptors on AgB-specific T and B cells share cross-reactive idiotypic determinants.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology* / Q000302:isolation & purification; D001402:B-Lymphocytes / Q000276:immunology; D002846:Chromatography, Affinity; D000939:Epitopes / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007375:Interleukin-1; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D011058:Pollen / Q000276:immunology*; D011506:Proteins / Q000276:immunology*; D011946:Receptors, Antigen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D007106:Immune Sera; D007130:Immunoglobulin Idiotypes; D007375:Interleukin-1; D011506:Proteins; D011946:Receptors, Antigen; D007073:Immunoglobulin E