[Coagulation studies and rheological measurements during streptokinase therapy of myocardial infarction (author's transl)].
In a multicenter, randomized trial of streptokinase in acute myocardial infarction one group of patients was given streptokinase for 24 h; the remainder served as controls and received a placebo infusion instead. Coagulation assays and rheological measurements were serially performed on patients entered into the trial at one of the participating centers. Streptokinase was found to improve considerably the flow properties of blood for a period of time exceeding the duration of its administration. These results may well explain the positive clinical effect of streptokinase therapy observed in this trial.
D000208:Acute Disease; D001777:Blood Coagulation / Q000187:drug effects*; D001809:Blood Viscosity / Q000187:drug effects; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D012712:Serum Globulins / Q000378:metabolism; D013300:Streptokinase / Q000627:therapeutic use*; D000511:alpha-Macroglobulins / Q000378:metabolism
D005338:Fibrin Fibrinogen Degradation Products; D012712:Serum Globulins; D000511:alpha-Macroglobulins; D005340:Fibrinogen; D013300:Streptokinase
Gerinnungsbefunde und rheologische Messungen bei Streptokinasebehandlung des akuten Myokardinfarktes.