title: [Factor VIII activity and factor VIII-associated antigen in healthy newborns and in newborns with stressing perinatal factors].
abstract: Factor VIII coagulation activity (VIII:C) and factor VIII associated antigen (VIII:AGN) were determined in healthy newborns and in children with charging perinatal factors ("risk children"). VIII:C values of healthy newborns may be compared with those of grown-ups with normal coagulation. Risk children have somewhat higher values than newborns, the difference, however, being statistically not significant. The concentration of VIII:AGN is clearly increased in both groups on the first day of life. Moreover, VIII:AGN is being eliminated more slowly in risk children. The increased VIII:AGN concentrations are considered as a sequel of stress conditions caused by birth, whereas the discrepancy between VIII:C and VIII:AGN is due to a thrombin effect.
mesh_terms: D001780:Blood Coagulation Tests; D002585:Cesarean Section; D005169:Factor VIII / Q000502:physiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D007744:Obstetric Labor Complications; D011247:Pregnancy; D012306:Risk; D013312:Stress, Physiological
chemical_list: D007519:Isoantigens; D005169:Factor VIII
vernacular_title: Faktor-VIII-Aktivität und Faktor-VIII-assoziiertes Antigen bei gesunden Neugeborenen und Neugeborenen mit belastenden perinatalen Faktoren.