title: Neurochemical changes in Creutzfeldt-Jakob disease.
abstract: A biochemical study of a case affected by Creutzfeldt-Jakob disease is reported. Changes were found in soluble and insoluble proteins, glycoproteins and mucopolysaccharides and in total lipids, glycolipids, phospholipids and gangliosides. Also CNPase, choline acetyltransferase, 5'-nucleotidase and several glycosidases have an altered activity. All these data give a complete neurochemical pattern of the changes underlying the morphological and functional alterations in this disease.
mesh_terms: D000368:Aged; D001834:Body Water / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D007562:Creutzfeldt-Jakob Syndrome / Q000201:enzymology*; D005260:Female; D005732:Gangliosides / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism
chemical_list: D005732:Gangliosides; D006023:Glycoproteins; D006025:Glycosaminoglycans; D009419:Nerve Tissue Proteins; D006026:Glycoside Hydrolases