Neurochemical evaluation of chlordecone toxicity in the mouse.
Plasma and brain levels of chlordecone in chlordecone-induced motor impairment, lethal levels of chlordecone, and cumulative LD50 of chlordecone in the mouse are presented. In terms of biochemical events, the possible contributory role of neurotransmitters in chlordecone-induced neurotoxicity is also discussed. On the basis of the data obtained so far, it is suggested that the dopaminergic pathway and its interaction with other neurotransmitter systems in the basal ganglia may be primarily involved in chlordecone-induced neurotoxicity.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D007631:Chlordecone / Q000378:metabolism / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D007306:Insecticides; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D005680:gamma-Aminobutyric Acid; D007631:Chlordecone