Induction of interferon by levamisole and concanavalin A in HA/ICR and NZB/W mouse spleen cells.
Levamisole alone and in combination with concanavalin A (Con A) induced interferon in splenic cultures of NZB/W and HA/ICR mice. Levamisole did not potentiate interferon induction by Con A. HA/ICR mice consistently produced greater amounts of interferon than NZB/W.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D005260:Female; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis*; D007700:Kinetics; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013154:Spleen / Q000187:drug effects / Q000378:metabolism*
D007369:Interferon Inducers; D003208:Concanavalin A; D007978:Levamisole; D007372:Interferons