Production of interferon and other lymphokines during murine tumour growth. II. Induction of an interferon by Ehrlich ascites cells in outbred mice.
A viral inhibitor produced in the peritoneal cavity of outbred Swiss mice inoculated with allogeneic Ehrlich ascites cells was identified as an interferon. It was antigenically related to viral interferons of type 1 and seems to be produced by macrophages. The interferon activity in the peritoneum reached maximal levels at 24 hr after tumour challenge. Interferon induction by Ehrlich ascites cells was not inhibited in lipopolysaccharide-hyporeactive mice. In addition, cell growth inhibition, enhanced interferon production after priming with small doses of this interferon, and increased susceptibility of cells treated with this interferon to the toxic effect of double-stranded RNA was demonstrated.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D003609:Dactinomycin / Q000494:pharmacology; D004355:Drug Stability; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007372:Interferons / Q000096:biosynthesis* / Q000276:immunology / Q000494:pharmacology; D051379:Mice; D009368:Neoplasm Transplantation; D013045:Species Specificity
D003609:Dactinomycin; D007372:Interferons