A/USSR and B/Hong Kong vaccine. Field experiences during an A/Brazil and an influenza B epidemic.
Young adults vaccinated in late spring of 1978 with one dose of vaccine containing either 7 microgram or 20 microgram of A/USSR (H1N1) hemagglutinin, followed by a dose of trivalent (A/USSR, A/Texas, B/Hong Kong) vaccine, were observed through an epidemic of A/Brazil influenza in the winter of 1978-1979, and of influenza B in 1979-1980. Influenza infection was diagnosed by virus isolation or serological titer rises between the spring seasons of 1978, 1979, and 1980. During the A/Brazil epidemic, rates of reported influenza-like illness and serologically confirmed H1N1 influenza infections were similar for all vaccine groups and two control groups. Naturally acquired antibody, but not vaccine-induced hemagglutination-inhibiting antibodies (HAI), appeared protective. During the influenza B epidemic, a lower rate of serologically confirmed infections was observed in the 1978 vaccine cohort than in one control group.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002986:Clinical Trials as Topic; D004196:Disease Outbreaks / Q000453:epidemiology*; D004311:Double-Blind Method; D000939:Epitopes; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000592:standards*; D007251:Influenza, Human / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D008875:Middle Aged; D014861:Washington
D000914:Antibodies, Viral; D000939:Epitopes; D007252:Influenza Vaccines