A comparison of temazepam and flurazepam in terms of sleep quality and residual changes in activation and performance.
A study was carried out in order to compare the effects of 40 mg of temazepam (Euhypnos) and 30 mg of flurazepam on sleep experience, and the residual effects on mood and performance of normal volunteers. The effects of the doses were compared with the identical placebos. A sleep experience questionnaire, an activation questionnaire and a rapid information processing test were administered in the morning, 10 h after ingestion. Both drugs produced the same subjective experience. However, large significant, residual effects of flurazepam were seen on activation and performance (correct detections and reaction times) while temazepam had little effect on activation and produced only a small significant residual impairment of reaction times.
D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D005260:Female; D005479:Flurazepam / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000503:physiopathology; D013693:Temazepam / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D013693:Temazepam; D005479:Flurazepam