[Phospholipid metabolism in acetylcholine and substance P induced desensitization of guinea pig ileum smooth muscle].
The amount and the rate of inorganic phosphate incorporation into mono-, di- and triphosphoinositides and into total phospholipids of ileum smooth muscle were studied at various time of exposure to physiological concentrations of acetylcholine and substance P. The data obtained show a phase character of the mediator influence on the phosphate incorporation into mono and triphosphoinositides-a stimulation initial period, an inhibition during the desensitization period and a return to the normal level after the mediator elimination.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000096:biosynthesis; D010743:Phospholipids / Q000096:biosynthesis*; D013373:Substance P / Q000494:pharmacology*
D010716:Phosphatidylinositols; D010743:Phospholipids; D013373:Substance P; D000109:Acetylcholine
Obmen fosfolipidov pri desensitizatsii Gladkomyshechnogo sloia ileuma morskikh svinok atsetilkholinom i veshchestvom p.