Metabolism of [14C]2-methylnaphthalene by rainbow trout (Salmo gairdneri) in vivo.
Rainbow trout were exposed to aqueous [14C]2-methylnaphthalene and their bile was examined for metabolites of [14C]2-methylnaphthalene. Trout which were pretreated with the monooxygenase inducer beta-naphthoflavone exhibited greater levels of total metabolites, glucuronide conjugates and dihydrodiol metabolites of [14C]2-methylnaphthalene in bile as compared to non-induced trout. The ratio of 2-hydroxymethyl-naphthalene to dihydrodiols found was greater in non-induced than in induced trout. These results are consistent with previously published studies on the metabolism of [14C]2-methylnaphthalene by rat and trout hepatic microsomes in vitro.
D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer; D005965:Glucuronates / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D009281:Naphthalenes / Q000378:metabolism*; D012487:Salmonidae / Q000378:metabolism*; D014337:Trout / Q000378:metabolism*; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D005965:Glucuronates; D009281:Naphthalenes; D019324:beta-Naphthoflavone; D005966:Glucuronidase; C027384:2-methylnaphthalene