Human T cell surface antigens bearing a structural relationship to HLA antigens.
Three cell surface antigens that are structurally related to the human major histocompatibility antigens (called HLA antigens) have been characterized from the leukemic T cell line MOLT-4. One antigen is a glycoprotein of Mr 49,000 recognized by two monoclonal antibodies. OKT6 and NA1/34, and is associated with a Mr 12,000 subunit that crossreacts serologically with beta 2-microglobulin but can be distinguished from it by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. A second antigen, defined by the monoclonal antibody OKT10, is a Mr 46,000 protein associated with a small subunit distinct from beta 2-microglobulin. The OKT10 antigen is not restricted to T cells and is found on all T and B lymphoblastoid cell lines tested. The third protein is a beta 2-microglobulin-associated glycoprotein of Mr 43,000 that is serologically distinct from the OKT6 (NA1/34), OKT10, and HLA antigens. It is found on some, but not all, T cell lines but is absent from any other hematopoietic cell lines tested.
D000936:Antigen-Antibody Complex; D000954:Antigens, Surface; D002999:Clone Cells / Q000276:immunology; D000939:Epitopes; D006023:Glycoproteins / Q000276:immunology; D006680:HLA Antigens; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D011487:Protein Conformation; D013601:T-Lymphocytes / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology
D000936:Antigen-Antibody Complex; D000954:Antigens, Surface; D000939:Epitopes; D006023:Glycoproteins; D006680:HLA Antigens; D046911:Macromolecular Substances; D001613:beta 2-Microglobulin