Alpha 1-antitrypsin and alpha 2-macroglobulin do not inhibit the kinin-releasing activity of kallikreins from human urine and saliva.
Alpha 1-Antitrypsin, alpha 2-macroglobulin and low-molecular weight kininogen were isolated from human serum and kallikreins from human urine and saliva. Alpha 1-antitrypsin and alpha 2-macroglobulin inhibited the activity of trypsin in releasing kinin from low-molecular weight kininogen, due to their binding with the enzyme, but did not inhibit or bind with urinary and salivary kallikreins.
D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism* / Q000652:urine; D007704:Kininogens / Q000378:metabolism; D007705:Kinins / Q000378:metabolism*; D008970:Molecular Weight; D012463:Saliva / Q000378:metabolism; D014357:Trypsin / Q000494:pharmacology; D000515:alpha 1-Antitrypsin / Q000494:pharmacology*; D000511:alpha-Macroglobulins / Q000494:pharmacology*
D007704:Kininogens; D007705:Kinins; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D007610:Kallikreins; D014357:Trypsin