title: Tensile strengths of paracetamol and Avicel powders and their mixtures.
abstract: Measurements were made of the tensile strengths of paracetamol and Avicel powders and of their mixtures. Two quantities were derived from the results; m, a universal constant whose value was 1.00 +/- 0.23 and alpha, a constant of the material. The value of alpha for paracetamol was much larger than that for Avicel and increased slightly with increase in particle size. Adding 25% w/w of Avicel to paracetamol produced a significant decrease in alpha and this fact may account for its use as an excipient in the tableting of paracetamol.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D010316:Particle Size; D013718:Tensile Strength
chemical_list: D005079:Excipients; D000082:Acetaminophen; D002482:Cellulose