Irradiation combined with bleomycin treatment of synchronized cells in culture under oxic and hypoxic conditions.
Bleomycin-treated cells are sensitized to radiation delivered under oxic conditions both in the early S and G2 phases of the cycle, irradiated under hypoxic conditions, sensitization occurs only in the early S phase. This difference in the sensitizing effect of the drug is discussed in regard to the possible clinical advantages of a combined treatment ot tumors with irradiation and Bleomycin.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D003470:Culture Media; D010100:Oxygen; D011829:Radiation Dosage
D003470:Culture Media; D001761:Bleomycin; D010100:Oxygen