[Effect of the cAMP-dependent phosphorylation of sheep erythrocyte membrane on their ability to induce a humoral immune response].
It was found that the immunization of mice with sheep red blood cells (SRBC) phosphorylated under conditions of cAMP synthesis induction led to a more than 3-fold decrease in the number of antibody-forming cells (AFC) in the mouse spleen as compared to control. Phosphorylation of SRBC led to a 2-fold and 3-fold reduction in the activity of cAMP-independent and cAMP-dependent protein kinases. It is assumed that the decreased immune response to phosphorylated SRBC is consequent on the inactivation of a certain percentage of SRBC antigenous determinants and that an important part in the recovery of their activity is played by the action of cAMP-dependent protein kinase membranes.
D000818:Animals; D000917:Antibody Formation; D000242:Cyclic AMP / Q000378:metabolism*; D000939:Epitopes; D004910:Erythrocyte Membrane / Q000201:enzymology / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006824:Hybridization, Genetic; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D012756:Sheep / Q000276:immunology*
D000939:Epitopes; D000242:Cyclic AMP; D011494:Protein Kinases
Vliianie tsAMF-zavisimogo fosforilirovaniia membran éritrotsitov barana na ikh sposobnost' k induktsii gumoral'nogo immunnogo otveta.