Interferon induction by and toxicity of polyriboinosinic acid [poly(rI)].polyribocytidylic acid [poly (rC)], mismatched analog poly (rI).poly[r(C12Uracil)n], and poly(rI).poly(rC) L-lysine complexed with carboxymethylcellulose.
The ability of polyriboinosionic acid [poly(rI)].polyribocytidylic acid [poly(rC)], mismatched analog poly (rI).poly[r(C12Uracil)n], and poly(rI).poly(rC) complexed with poly L-lysine and carboxymethylcellulose [poly(ICLc)] to induce interferon and the comparative toxicity of each in cats were evaluated. Each induced high levels of circulating interferon, although poly(ICLC) injected intravenously at 1 to 4 mg/kg induced up to 10 times more interferon than the other compounds. Each compound was pyrogenic and caused a transient decrease in leukocyte numbers. Poly(rI).poly(rC) and the mismatched analog caused severe diarrhea and nausea at the highest drug concentrations (1 to 4 mg/kg), but poly (ICLC) did not. Each compound also caused depression and lethargy and impaired coordination.
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000139:chemically induced; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D010455:Peptides / Q000494:pharmacology*; D011066:Poly C / Q000494:pharmacology; D011069:Poly I / Q000494:pharmacology; D011070:Poly I-C / Q000494:pharmacology; D011107:Polylysine / Q000494:pharmacology*; D011131:Polyribonucleotides / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors
D007369:Interferon Inducers; D010455:Peptides; D011131:Polyribonucleotides; D011107:Polylysine; D011069:Poly I; D011066:Poly C; D008747:Methylcellulose; D007372:Interferons; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C