[Cholestatic jaundice induced by D-penicillamine and oral steroid contraceptive in progressive systemic sclerosis (author's transl)].
A 25-year-old woman with progressive systemic sclerosis was treated with D-penicillamine. (DPA) 30 days after starting therapy cholestatic jaundice was observed. Moreover, for two years she has taken the pill. Both drugs were discontinued, the jaundice disappeared and the laboratory findings of liver became normal. A rechallenge of D-penicillamine after 9 months induced no reaction. An underlying chronic liver disease before cholestasis could be excluded by liver biopsy. Allergic cutantests and lymphocyte transformation test with D-penicillamine and penicillin gave normal results. The frequency of cholestatic jaundice caused by DPA-therapy is discussed and the possible pathomechanism analyzed.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002715:Chlormadinone Acetate / Q000009:adverse effects*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D009640:Norethindrone / Q000009:adverse effects*; D010396:Penicillamine / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000175:diagnosis / Q000188:drug therapy*
D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; D002715:Chlormadinone Acetate; C010260:Non-Ovlon; D000410:Alanine Transaminase; D010396:Penicillamine; D001663:Bilirubin; D009640:Norethindrone
Ikterus durch D-Penizillamin und hormonale Kontrazeption bei progressiver Sklerodermie.