First Japanese family with the unstable hemoglobin Zürich [beta 63(e7) His leads to Arg].
Abnormal hemoglobin, which was latter identified as hemoglobin Zürich, was discovered in a 45-year-old female with severe valvular heart disease, congestive heart failure and moderate anemia and hyperbilirubinemia. Same abnormal hemoglobin was demonstrated in her two apparently healthy sons. This is the first reported family of hemoglobin Zürich in Japan.
D000293:Adolescent; D000328:Adult; D000743:Anemia, Hemolytic / Q000150:complications; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006333:Heart Failure / Q000150:complications; D006349:Heart Valve Diseases / Q000150:complications; D006441:Hemoglobin A / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications; D007564:Japan; D008297:Male; D008875:Middle Aged
D006455:Hemoglobins, Abnormal; D006441:Hemoglobin A; D005319:Fetal Hemoglobin; C025978:hemoglobin Zurich