Effects of chloral hydrate, gamma-butyrolactone, and equithesin on the efflux of dopamine and 5-hydroxytryptamine metabolites into cerebroventricular perfusates of rats.
Chloral hydrate, gamma-butyrolactone, and Equithesin are general anesthetics which have been employed in a variety of neurochemical and electrophysiological experiments. The effects of these anesthetics on the efflux of dopamine and 5-hydroxytryptamine metabolites into lateral cerebroventricular perfusates were determined in rats bearing chronically implanted cannulas. Chloral hydrate and Equithesin increased, whereas gamma-butyrolactone decreased, the efflux of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid. None of the anesthetics had a consistent effect on the efflux of the 5-hydroxytryptamine metabolite 5-hydroxyindoleacetic acid.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000378:metabolism*; D002697:Chloral Hydrate / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004338:Drug Combinations / Q000494:pharmacology; D005663:Furans / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D004338:Drug Combinations; D005663:Furans; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; C034864:chloropent; D002697:Chloral Hydrate; D006897:Hydroxyindoleacetic Acid; D008278:Magnesium Sulfate; D010424:Pentobarbital; D015107:4-Butyrolactone; D004298:Dopamine; D006719:Homovanillic Acid