Relationship between pancreatic and serum amylase in basal conditions and during stimulation in man. Report of a new intraoperative technique.
The correlation between serum amylase and pancreatic amylase secretion was studied in two patients. Both patients underwent sphincterotomy, and the pancreatic duct was cannulated with a polyethylene tube. The tube was left in place for 15 to 21 days. The rate of amylase secretion over 7 days was studied in response to (1) a standard meal, (2) duodenal acidification, (3) scalar doses of cholecystokinin, (4) scalar doses of secretin, and (5) scalar doses of secretin with simultaneous infusion of cholecystokinin. Blood samples were collected during the tests to measure serum amylase. No significant correlation was shown between blood concentration and output of amylase in any of the tests. Our findings show that under normal conditions serum amylase levels are not influenced by pancreatic secretion and suggest that serum amylase concentration is not related to pancreatic exocrine secretion.
D000328:Adult; D000681:Amylases / Q000032:analysis* / Q000097:blood; D002766:Cholecystokinin; D002863:Chromogenic Compounds; D005502:Food; D006801:Humans; D006851:Hydrochloric Acid; D008297:Male; D008875:Middle Aged; D010186:Pancreatic Function Tests; D010189:Pancreatic Juice / Q000032:analysis*; D012633:Secretin
D002863:Chromogenic Compounds; D012633:Secretin; D002766:Cholecystokinin; D000681:Amylases; D006851:Hydrochloric Acid