The dual interaction of prostaglandin E2 (PGE2) and interferon (IFN) on NK lytic activation: enhanced capacity of effector-target lytic interactions (recycling) and blockage of pre-NK cell recruitment.
In this study we addressed the question of whether the known NK activators prostaglandin E2 (PGE2) and interferon (IFN) can synergistically activate NK lysis and whether they potentiate the same or different subsets of NK cells. We demonstrated that the activation of NK lysis can be enhanced as well as blocked by the interaction of these 2 activators. The enhancement of activation was not due to recruitment of separate subsets of pre-NK cells, but rather the synergistic enhancement of the recycling capabilities of the same set of NK cells. There was a temporal relationship to this enhancement. That is, if PGE2 was added during cellular processing required for full expression of NK activation induced by IFN, pre-NK lytic potential was inhibited. If, on the other hand, PGE2 is added after completion of full expression of the IFN-induced activated lytic process, there is enhancement of recycling capabilities of the same number of NK cells.
D003602:Cytotoxicity, Immunologic; D004347:Drug Interactions; D004357:Drug Synergism; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D013997:Time Factors
D011458:Prostaglandins E; D007372:Interferons