Injury restricted to cells infected with spotted fever group rickettsiae in parabiotic chambers.
One chamber of paired parabiotic chambers separated by 0.2 micron poresized membrane filters which prevented passage of rickettsiae were infected with either Rickettsia rickettsii or R. conorii. Infected VERO cell monolayers underwent necrosis. Uninfected monolayers in adjoining chambers which shared the same extracellular milieu including soluble rickettsial products did not undergo necrosis.
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival; D002522:Chlorocebus aethiops; D007668:Kidney; D010740:Phospholipases / Q000378:metabolism; D012281:Rickettsia / Q000201:enzymology / Q000472:pathogenicity*; D012284:Rickettsia rickettsii / Q000201:enzymology / Q000472:pathogenicity*
D001427:Bacterial Toxins; D010740:Phospholipases