Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein.
Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.
D000818:Animals; D002118:Calcium / Q000502:physiology; D004205:Cromolyn Sodium / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007700:Kinetics; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008970:Molecular Weight; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors
D010750:Phosphoproteins; D003189:p-Methoxy-N-methylphenethylamine; D004205:Cromolyn Sodium; D002118:Calcium