Diet and adjuvant-induced arthritis in the rat.
Rats fed a high carbohydrate or a high protein diet deficient in copper, magnesium or zinc, or in the three trace elements together, failed to develop adjuvant-induced arthritis, yet a deficiency of both copper and magnesium in the diets exhibited no such inhibition. On the other hand, only a magnesium deficiency reduced the severity of the dextran anaphylactoid reaction.
D000707:Anaphylaxis / Q000139:chemically induced; D000818:Animals; D001168:Arthritis / Q000178:diet therapy*; D001169:Arthritis, Experimental / Q000178:diet therapy*; D003300:Copper / Q000172:deficiency*; D003911:Dextrans / Q000009:adverse effects; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D008275:Magnesium Deficiency / Q000378:metabolism; D008297:Male; D051381:Rats; D015032:Zinc / Q000172:deficiency
D003911:Dextrans; D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D003300:Copper; D015032:Zinc