title: [Role of the beta-subunits of Escherichia coli RNA-polymerase in the regulation of gene activity].
abstract: The DNA-dependent RNA-polymerase from E. coli B/r and its rif-r mutant rpoB409 with pleiotropic effect has been studied. It was shown, that multiple forms of promotor sites in T4- and T7-DNA "early" regions are recognized with different efficiences by RNA-polymerases from E. coli B/r and rpoB409. The rif-r rpoB409 mutation has been reported to affect the beta-subunit. Thus, the present data indicates that the selection of promoter sites can be controlled by the beta-subunit of RNA-polymerase.
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics; D055598:Chemical Phenomena; D002621:Chemistry; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D008837:Micrococcus / Q000235:genetics; D009711:Nucleotides / Q000494:pharmacology; D009876:Operon; D012313:RNA / Q000096:biosynthesis*; D012265:Ribonucleotides / Q000494:pharmacology; D013604:T-Phages / Q000235:genetics; D013950:Thymus Gland / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D009711:Nucleotides; D012265:Ribonucleotides; D012313:RNA; D012321:DNA-Directed RNA Polymerases
vernacular_title: Rol' beta-sub" edinitsy RNK-polimerazy Escherichia coli v reguliatsii genov.