title: The pharmacokinetics in man of SK&F 93319--a new antagonist of histamine H1 and H2 receptors.
abstract: SK&F 93319, a potent histamine H1- and H2-receptor antagonist, is rapidly absorbed with a low rate of plasma clearance primarily by metabolism. Excretion is divided evenly between urine and faeces (probable biliary elimination) with little unchanged drug in the urine. Serum protein binding at low concentrations is very extensive and appears to restrict distribution of SK&F 93319. At higher concentrations (higher dose levels) reduced protein binding results in a marked proportional increase in available free drug with a consequent increase in distribution and clearance. Bioavailability is reduced at higher dose levels. The importance of factors contributing to non-linear pharmacokinetics and the potential clinical consequences are demonstrated.
mesh_terms: D000328:Adult; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism; D005243:Feces / Q000032:analysis; D006634:Histamine H1 Antagonists / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011485:Protein Binding; D011725:Pyridines / Q000097:blood* / Q000652:urine
chemical_list: D001798:Blood Proteins; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D011725:Pyridines; C043465:icotidine