Blood pressure homeostasis in Rana catesbeiana under normal and hypovolemic conditions.
The effects of phentolamine, KBIV24 and captopril on the mean arterial blood pressure of normal and treated (dehydration, hemorrhage) frogs were determined. Hemorrhage but not dehydration led to a decrease in MAP. Only phentolamine attentuated MAP in both normal and treated frogs. KBIV24 and captopril were ineffective. It was concluded that the blood pressure of frogs is regulated by catecholamine. Neither arginine vasotocin nor the renin-angiotensin system play any role in blood pressure homeostasis in normal and hypovolemic conditions.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D002395:Catecholamines / Q000502:physiology; D003681:Dehydration / Q000503:physiopathology; D006470:Hemorrhage / Q000503:physiopathology; D006706:Homeostasis / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology; D011892:Rana catesbeiana; D012084:Renin-Angiotensin System / Q000187:drug effects; D012769:Shock / Q000503:physiopathology*
D002395:Catecholamines; D002216:Captopril; D010646:Phentolamine