Resistance to interferon of a human adenocarcinoma cell line, HEC-1, and its sensitivity to natural killer cell action.
A human endometrial cancer cell line, HEC-1, was found to be resistant to the antiviral and anticellular action of interferon. However, HEC-1 cells were susceptible to the cytotoxicity of natural killer (NK) cells, and interferon enhanced such NK activity. When HEC-1 cells were treated with interferon, sensitivity of HEC cells to the cytotoxicity of NK cells was not suppressed.
D000230:Adenocarcinoma; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology*; D014594:Uterine Neoplasms; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development
D007372:Interferons