title: G2-delay after irradiation with alpha-particles as studied in synchronized cultures and by the bromodeoxyuridine-33258H technique.
abstract: Division delay of mouse L-929 fibroblasts after alpha-irradiation is due to a pronounced lengthening of their G2-phase. Experiments on synchronously and asynchronously growing cultures revealed a cell cycle phase-dependent sensitivity of this effect: Cells irradiated in G2 or at the G1/S border suffered a longer G2-delay than cells irradiated at mid- or late-S. Progression through G2 was nearly normal at doses up to 0.3 Gy if cells were exposed during G1 phase.
mesh_terms: D000512:Alpha Particles; D000818:Animals; D006690:Bisbenzimidazole; D001973:Bromodeoxyuridine; D005434:Flow Cytometry; D007399:Interphase / Q000528:radiation effects*; D007700:Kinetics; D007739:L Cells; D051379:Mice
chemical_list: D001973:Bromodeoxyuridine; D006690:Bisbenzimidazole