title: Antibody-dependent redistribution and release of immunological complexes in cells of human chronic leukemias.
abstract: Redistribution and the ability for removing immunological complexes in CLL and CGL cells treated with the specific anti-leukemia antigens were investigated. The immunofluorescence method at 4 and 37 degrees C was applied at different times of cell incubation with antigens. It was shown, that incubation at 4 degrees C even carried out for 18 h, neither caused a clear aggregation nor a release of immunological complexes from the leukemia cell surface, whereas at 37 degrees C considerable differences in mobility of CLL and CGL cells were observed. In CGL cells quite a rapid redistribution followed by the removal of antigen-antibody complexes was observed, while CLL cells have shown the ability for aggregation only, without clear polarization and without releasing the formed complex from the cell surface.
mesh_terms: D000936:Antigen-Antibody Complex; D001666:Binding Sites, Antibody; D006801:Humans; D007106:Immune Sera; D007152:Immunologic Capping; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007951:Leukemia, Myeloid / Q000276:immunology*
chemical_list: D000936:Antigen-Antibody Complex; D007106:Immune Sera