T helper cells in immune mice amplify the primary anti-tumor cytotoxic response.
In this report we examine the influence of splenic helper cells in the primary cytotoxic T lymphocyte (CTL) response against syngeneic murine leukemia virus-(MuLV) induced tumor cells. We identify an Lyt-1+ 800 R radiation-resistant helper T cell that will amplify the in vitro generation of CTL against syngeneic tumor cells from nonimmune spleen cells.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics; D000954:Antigens, Surface / Q000235:genetics; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006183:H-2 Antigens / Q000235:genetics; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D018800:Thy-1 Antigens; D013997:Time Factors
D000950:Antigens, Ly; D000954:Antigens, Surface; D000939:Epitopes; D006183:H-2 Antigens; D018800:Thy-1 Antigens