title: The influence of lanthanons on morphology and function of rat exocrine pancreas in vivo.
abstract: The intravenously administered light lanthanon praseodymium selectively destroys the Golgi complex of rat exocrine pancreas. This effect impairs the normal secretion of proteolytic enzymes which manifests in a reduced output of amylase and trypsin from rat pancreas and a decrease of the basal level of amylase in serum after pilocarpine stimulation.
mesh_terms: D000681:Amylases / Q000097:blood / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors; D005260:Female; D006056:Golgi Apparatus / Q000648:ultrastructure; D008854:Microscopy, Electron; D010179:Pancreas / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D010862:Pilocarpine; D011221:Praseodymium / Q000494:pharmacology*; D051381:Rats; D014357:Trypsin / Q000378:metabolism
chemical_list: D010862:Pilocarpine; D000681:Amylases; D014357:Trypsin; D011221:Praseodymium; D002118:Calcium