[Potentials for the combined use of gentamycin with gamma globulin and vitamins].
Rabbits and pigs were used to study the resorption and retention of gentamycin dissolved in swine gamma globulin, swine polyglobulin, in water (gentamycin ampoules) and as a combined preparation with gamma-globulin and vitamins (gentaglobin). It was found that the protein solutions of gentamycin as compared to the water solutions at i/m application to rabbits and pigs give higher and persistent concentrations in the blood serum. At muscular application to pigs at the rate of 0.002/kg gentaglobin was retained in bacteriostatic concentrations in the blood serum for 12 hours. In pigs the gentamycin preparation, no matter what solvent was used, was eliminated comparatively very quickly through the bile and urine. It is stated that the quarantine for gentaglobin-treated pigs intended for slaughter should be 72 hours, the kidneys of such animals being excluded from human consumption. Gentamycin in the gentaglobin preparation has been found to retain its activity in the course of one year at +4 degrees C.
D000818:Animals; D004341:Drug Evaluation / Q000662:veterinary; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007273:Injections, Intramuscular; D011817:Rabbits; D012996:Solutions; D013552:Swine; D013997:Time Factors; D014815:Vitamins / Q000008:administration & dosage; D005719:gamma-Globulins / Q000008:administration & dosage*
D005839:Gentamicins; D012996:Solutions; D014815:Vitamins; D005719:gamma-Globulins
Vŭzmozhnosti za kombinirano prilagane na gentamitsin s gama-globulin i vitamini.