Topical application of lindane cream (Kwell) and antipyrine metabolism.
The transcutaneous absorption of a 1% lindane cream (Kwell) was determined after application according to the official label. By 3 days after application the plasma lindane level increased from nondetectable to 10.3 +/- 2.2 ng/ml. Sufficient lindane was absorbed to increase the plasma clearance of antipyrine from 0.027 +/- 0.009 to 0.037 +/- 0.011 1/kg/hr (p less than 0.05). these findings indicate significant transcutaneous absorption of lindane occurs following a single application and are compatible with the neurological toxicity reported following the topical application of lindane cream.
D000287:Administration, Topical; D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D001921:Brain / Q000187:drug effects; D005260:Female; D001556:Hexachlorocyclohexane / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D008297:Male; D012869:Skin Absorption
D001556:Hexachlorocyclohexane; D000983:Antipyrine