Clinical dextrans lack mitogenic activity for normal human lymphocytes in vitro.
In vitro studies on mitogenic stimulation of lymphocytes from a panel of normal volunteers revealed no transformation in response to the presence of dextran 40, 70, 110 or 150 at concentrations ranging from 0.8 to 8,000 microgram/ml. High molecular weight native dextran B512 was mitogenic in 1 individual only. In addition, neither Leuconostoc-derived nor fermentation medium-derived moieties, sometimes present in clinical dextrans, were implicated as lymphocyte mitogens. It is concluded on the basis of these findings that clinical dextrans of average molecular weight 40,000--150,000 are not B- or T-cell mitogens.
D003911:Dextrans / Q000494:pharmacology*; D006801:Humans; D007934:Leuconostoc; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology*; D008970:Molecular Weight; D013936:Thymidine / Q000378:metabolism
D003911:Dextrans; D008934:Mitogens; D013936:Thymidine