Influence of bleomycin and pepleomycin on mitogen stimulations of human lymphocytes in vitro.
Bleomycin (BLM) and Pepleomycin (PEP), two antineoplastic drugs, strongly inhibited PHA-triggered DNA-synthesis of human lymphocytes when present during the culture period. Preincubation of lymphocytes with BLM or PEP for 3 days, however, only reduced the subsequent PHA-stimulations at very high drug concentrations. This differential sensitivity of resting and activated lymphocytes made it possible to inactivate subsets of mitogen or MLC reactive lymphocytes with a high grade of selectivity.
D000328:Adult; D001761:Bleomycin / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008222:Lymphokines; D008297:Male; D008934:Mitogens; D017663:Peplomycin
D008222:Lymphokines; D008934:Mitogens; D003208:Concanavalin A; D001761:Bleomycin; D017663:Peplomycin