title: Inhibition of intraocular proliferations with intravitreal corticosteroids.
abstract: Autotransplantation of one fourth million tissue cultured fibroblasts from rabbit rump skin into the vitreous cavity resulted in intravitreal strand formation and traction retinal detachment (27 of 47 eyes, 57%). A single intravitreal injection of 1 mg of dexamethasone alcohol inhibited fibroblast growth as judged by the significantly reduced number of retinal detachments (11 of 46 eyes, 24%). Retinal neovascularization that was observed when fibrous strands came into contact with vascularized retina (nine of 47 eyes, 19%) was also inhibited after corticosteroid application (two of 46 eyes, 4%).
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000637:transplantation*; D009389:Neovascularization, Pathologic / Q000187:drug effects; D011817:Rabbits; D012163:Retinal Detachment / Q000517:prevention & control; D014182:Transplantation, Autologous; D014822:Vitreous Body / Q000473:pathology*
chemical_list: D003907:Dexamethasone