Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions.
The nucleotide sequence of the 3'-terminal untranslated region and a portion of the coding region of rat alpha-fetoprotein mRNA has been determined from a cloned double-stranded cDNA. the amino acid sequence of the COOH-terminal portion of alpha-fetoprotein was inferred from the nucleotide sequence and compared to the amino acid sequence of the corresponding portion of rat, bovine, and human albumin. A striking homology in amino acid sequence between alpha-fetoprotein and albumin was observed. These results confirm earlier suggestions that the two proteins are closely related in structure and probably arose from a common ancestral gene.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D004262:DNA Restriction Enzymes; D004274:DNA, Recombinant / Q000378:metabolism; D005815:Genetic Code; D006801:Humans; D010957:Plasmids; D014176:Protein Biosynthesis; D051381:Rats; D012709:Serum Albumin / Q000096:biosynthesis*; D012710:Serum Albumin, Bovine / Q000096:biosynthesis; D013045:Species Specificity; D014158:Transcription, Genetic; D000509:alpha-Fetoproteins / Q000096:biosynthesis
D004274:DNA, Recombinant; D012709:Serum Albumin; D000509:alpha-Fetoproteins; D012710:Serum Albumin, Bovine; D004262:DNA Restriction Enzymes