Chlamydial prostatitis in dogs: an experimental study.
Ten adult male mongrel dogs were inoculated with Chlamydia trachomatis by injections of 10(6) or 10(7) organisms directly into the prostate. We were able to recover Chlamydia 3 to 7 days later in three of four dogs receiving injections of 10(7) organisms. Eight of ten dogs developed detectable serum antibody to Chlamydia 14 to 68 days following inoculation. All dogs receiving 10(7) Chlamydia and two of six dogs receiving 10(6) organisms developed histological signs of prostatic hyperplasia. Thus, the dog may be a model for establishment of chlamydial prostatitis and may be used for further investigations of this disease.
D000818:Animals; D002692:Chlamydia trachomatis / Q000472:pathogenicity*; D004285:Dogs; D005455:Fluorescent Antibody Technique; D008297:Male; D008954:Models, Biological; D011467:Prostate / Q000276:immunology / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000209:etiology; D011472:Prostatitis / Q000150:complications / Q000276:immunology / Q000382:microbiology*