Inhibition of hepatic drug metabolism by (+)-cyanidanol-3 (Catergen) in chronic alcoholic liver disease.
There are some controversies regarding the effect of (+)-cyanidanol-3 on hepatic drug metabolism. In the present study the effect of (+)-cyanidanol-3 was investigated on the microsomal and mitochondrial enzyme functions (hydroxylation, glucuronide production, D-glucaric acid excretion and acetylation) in alcoholic liver disease. Eight patients with biopsy-proven chronic alcoholic hepatitis were investigated before and after a 10-day, as well as after a further 30-day, treatment with (+)-cyanidanol-3 (Catergen), 3000 mg/day orally. Besides biochemical liver function tests (serum bilirubin levels, GOT, GGT), antipyrine metabolic clearance rate, mentholglucuronide production, urinary D-glucaric acid excretion and sulphadimidine kinetics were determined. Biochemical liver function tests improved markedly after the first period of treatment, at the same time antipyrine metabolic clearance rate decreased. Menthol-glucuronide production and D-glucaric acid excretion decreased significantly only after the second two course of Catergen administration. Sulphadimidine kinetics was not remarkably changed. Our findings suggest that (+)-cyanidanol-3 inhibits the hepatic microsomal drug metabolizing enzyme function in chronic alcoholic hepatitis.
D000328:Adult; D000983:Antipyrine / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001578:Benzopyrans / Q000627:therapeutic use*; D002392:Catechin / Q000627:therapeutic use*; D005937:Glucaric Acid / Q000378:metabolism; D005965:Glucuronates / Q000378:metabolism; D006519:Hepatitis, Alcoholic / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D008658:Inactivation, Metabolic / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D008610:Menthol / Q000031:analogs & derivatives / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000187:drug effects; D013418:Sulfamethazine / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D001578:Benzopyrans; D005965:Glucuronates; D008610:Menthol; D013418:Sulfamethazine; C044963:menthol glucuronide; D002392:Catechin; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D005937:Glucaric Acid; D000983:Antipyrine