Cytolytic T lymphocyte precursors reactive against mutant Kb alloantigens are as frequent as those reactive against a whole foreign haplotype.
Minimal frequencies of CTL-P in C57BL/6 spleen responding to H-2 mutational or whole haplotype differences were estimated by using a limiting dilution MLC technique. The frequency of CTL-P reacting against cells from each of three different H-2Kb mutant strains, carrying H-2 haplotypes ba, bg2, or bh, was determined to be within the range of frequencies of CTL-P directed against cells from strains carrying the independently derived H-2d and H-2k haplotypes.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D005787:Gene Frequency; D006183:H-2 Antigens / Q000235:genetics*; D006238:Haploidy; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D011995:Recombination, Genetic; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000939:Epitopes; D006183:H-2 Antigens