B-thromboglobulin content of human blood platelets.
There was a reduction in the B-thromboglobulin content of human blood platelets in patients with leukaemia after chemotherapy which inhibited platelet production. Thus, in these patients, as the circulating platelet population ages, B-thromboglobulin leaks out of, or is actively secreted by, platelets which remain in the circulation.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001609:Beta-Globulins / Q000032:analysis*; D001792:Blood Platelets / Q000032:analysis* / Q000187:drug effects; D002470:Cell Survival; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D010976:Platelet Count; D001620:beta-Thromboglobulin / Q000032:analysis*
D000970:Antineoplastic Agents; D001609:Beta-Globulins; D001620:beta-Thromboglobulin