ATP induced polarization of keratohyalin granules.
Within seconds of exposure of frozen sections of stratum granulosum of glycerinized cow hoof to a buffered solution of adenosinetriphosphate, the keratohyalin granules underwent transformation into polarized fine linear rods. This polarization phenomenon was associated wtih gross pleating, twisting and crumpling of the section, indicative of varying contractile forces.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D003594:Cytoplasmic Granules / Q000187:drug effects*; D004817:Epidermis / Q000187:drug effects* / Q000648:ultrastructure; D006724:Hoof and Claw; D006818:Hyalin; D066298:In Vitro Techniques; D008858:Microscopy, Phase-Contrast
D000255:Adenosine Triphosphate