The role of histamine H-receptors in the anaphylactic histamine release from human basophilic leukocytes.
The effect of two recently synthetized selective histamine H2-receptor agonists on anaphylactic histamine release from human basophilic leukocytes was investigated. It was found that both agonists tested, partially inhibited histamine release induced either by antigen or by human anti-IgE. Cimetidine, the histamine H2-receptor antagonist, generally antagonized this effect. It is concluded that anaphylactic basophil histamine release can be modulated by stimulation of histamine H2-receptors.
D000707:Anaphylaxis / Q000378:metabolism*; D001491:Basophils / Q000187:drug effects / Q000378:metabolism*; D002927:Cimetidine / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D017446:Impromidine; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology*
D006146:Guanidines; D007093:Imidazoles; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D002927:Cimetidine; D017446:Impromidine