Establishment in continuous culture of a T-lymphoid cell line (HD-Mar) from a patient with Hodgkin's lymphoma.
A new cell line, HD-Mar, was established from a pleural effusion of a patient with Hodgkin's lymphoma. Formation of E rosettes, sensitivity to anti-T serum, elevated terminal deoxynucleotidyl transferase activity, presence of T-cell and the common ALL membrane antigens, morphology, and cytochemical staining indicate that the HD-Mar line is of thymic derivation. Absence of any immunoglobulin determinants, the lack of EBNA or any other EBV-associated antigen or function are also characteristics associated with established T-cell-derived lymphoma cell lines. Karyotype analysis indicated a tetraploid origin of the cell line.
D000328:Adult; D000956:Antigens, Viral; D002460:Cell Line; D002877:Chromosomes, Human; D003176:Complement C3; D004253:DNA Nucleotidylexotransferase / Q000378:metabolism; D000939:Epitopes; D004854:Herpesvirus 4, Human / Q000276:immunology; D006689:Hodgkin Disease / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000032:analysis; D008297:Male; D008855:Microscopy, Electron, Scanning; D010996:Pleural Effusion / Q000166:cytology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D011951:Receptors, Complement / Q000032:analysis; D011991:Receptors, Virus / Q000032:analysis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure
D000956:Antigens, Viral; D003176:Complement C3; D000939:Epitopes; D007141:Immunoglobulin Fc Fragments; D011947:Receptors, Antigen, B-Cell; D011951:Receptors, Complement; D011991:Receptors, Virus; D004253:DNA Nucleotidylexotransferase