title: Respiratory hypersensitivity to Ascaris extract in guinea pigs sensitized by aerosol.
abstract: Guinea pigs exposed via the respiratory route to Ascaris suum extract in aerosol form became hypersensitive. The hypersensitivity was detectable by inhalational bronchial provocation testing using a noninvasive plethysmography, by chopped lung histamine release, and by passive cutaneous anaplylaxis. The antibody responsible for the hypersensitivity seems to be directly associated with pulmonary tissue. A locally produced cytotropic pulmonary antibody, probably IgG or IgE may be causal. Histopathology included only a moderate pulmonary eosinophilia. Individual variability in susceptibility to experimental allergic asthma may be controlled by both physiologic and immunologic reactivities.
mesh_terms: D000336:Aerosols; D000818:Animals; D001200:Ascaris / Q000276:immunology*; D001985:Bronchial Provocation Tests; D006168:Guinea Pigs; D006636:Histamine Release; D008168:Lung / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D011234:Precipitins; D012130:Respiratory Hypersensitivity / Q000276:immunology*; D012882:Skin Tests
chemical_list: D000336:Aerosols; D011234:Precipitins