Development of a transient retino-retinal pathway in hooded and albino rats.
Intraocular HRP injections in E16-21 embryos show that during the normal development of the central optic projections in hooded and albino rats many optic axons grow through the chiasm into the contralateral eye. This retino-retinal projection disappears shortly after birth. This suggests that an initial, imprecise guidance of growing axons is followed by a selective elimination of axons taking aberrant pathways and failing to make appropriate synapses.
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000502:physiology; D005260:Female; D007839:Functional Laterality; D006735:Horseradish Peroxidase; D009900:Optic Nerve / Q000196:embryology*; D011247:Pregnancy; D051381:Rats; D012160:Retina / Q000196:embryology*; D013477:Superior Colliculi / Q000196:embryology*; D013569:Synapses / Q000502:physiology
D006735:Horseradish Peroxidase