Clinical implications of recent advances in hemoglobin disorders.
The greater availability of sophisticated diagnostic procedures has led to the discovery of more than 350 abnormal human hemoglobins. Whereas most are clinically silent, in a sizeable number of variants, function anomalies and disease states. Their more clinically relevant aspects are discussed.
D000755:Anemia, Sickle Cell / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D001803:Blood Transfusion; D005260:Female; D005319:Fetal Hemoglobin / Q000096:biosynthesis; D005914:Globins / Q000235:genetics; D006453:Hemoglobinopathies / Q000175:diagnosis*; D006455:Hemoglobins, Abnormal; D006358:Hot Temperature; D006801:Humans; D008107:Liver Diseases / Q000150:complications; D008171:Lung Diseases / Q000150:complications; D009154:Mutation; D010100:Oxygen / Q000097:blood; D011086:Polycythemia / Q000209:etiology; D011247:Pregnancy; D013789:Thalassemia / Q000145:classification / Q000235:genetics
D006455:Hemoglobins, Abnormal; D005914:Globins; D005319:Fetal Hemoglobin; D010100:Oxygen