Sensitisation to Mallory bodies (alcoholic hyalin) in alcoholic hepatitis.
Using a leucocyte migration inhibition test sensitisation to Mallory bodies (alcoholic hyalin) was found in a statistically significant 41% of 17 patients with alcoholic hepatitis. Patients with alcohol-induced fatty liver and cirrhosis did not demonstrate sensitisation. Mallory bodies are a characteristic feature of alcohol-induced liver damage, and immunological sensitisation to them might lead to liver cell death and cell progression of the hepatitis process.
D002464:Cell Migration Inhibition; D004721:Endoplasmic Reticulum / Q000276:immunology*; D005235:Fatty Liver, Alcoholic / Q000276:immunology; D006519:Hepatitis, Alcoholic / Q000276:immunology*; D006801:Humans; D006818:Hyalin / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D008099:Liver / Q000276:immunology / Q000648:ultrastructure; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology