Effect of aprotinin on growth of 3-methylcholanthrene-induced squamous cell-carcinoma in mice.
The effect of aprotinin (Trasylol), a broad-spectrum inhibitor of proteinase, was studied on the growth of murine squamous cell carcinoma induced by 3-methylcholanthrene. In this tumor system, the administration of aprotinin was therapeutically effective. Histologically, aprotinin-treated tumor showed a significant hyperkeratosis.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology*; D005260:Female; D008748:Methylcholanthrene; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology*
D008748:Methylcholanthrene; D007611:Aprotinin