[Leukocyte migration inhibition test in multiple sclerosis - results of a migration technic according to Clausen using brain specific antigens].
The leukocyte migration inhibitory factor (LIF) was examined in 57 test persons--27 patients with multiple sclerosis (MS) and 30 normals--with the indirect and the direct leucocyte migration inhibition test in agarose (LMIAT). The stimulation of lymphocytes was carried out by the application of myelin basic protein (BP) and a membrane-associated antigen of normal brain (NTA). The mean value of controls +/- 2 s and the migration index less than or equal to 0,80 were used for limiting. In the indirect technique could be established significant group effects (NTA- and BP-values of MS cases compared to the controls) after 10 hours of incubation. The direct method showed in MS patients a significant lowered migration-index on an average after stimulation with the NTA; controls gave negative findings (except two cases). The valence of the test system and prospective modifications for further results were indicated.
D000328:Adult; D001921:Brain / Q000276:immunology*; D002464:Cell Migration Inhibition; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology
D000939:Epitopes; D004676:Myelin Basic Protein
Leukozytenmigrations-Inhibitionstest bei Multipler Sklerose - Ergebnisse mit der Migrationstechnik nach Clausen bei Anwendung hirhtypischer Antigene.