Human antithrombin III heterogeneity.
Crossed immunoelectrophoretic patterns were obtained on three patients with a congenital deficiency of anti-thrombin III (AT-III), and on normal single donor and "pooled" plasma controls. In the presence of heparin (incorporated into the agarose gel matrix), the AT-III of normal human plasma was separated into four components: two major, faster-moving components, and two minor, slower-moving components. The three patients with congenital deficiency of AT-III (levels approximately 50% of normal) appeared to possess only one of the faster-moving components, and one of the slower-moving components.
D000990:Antithrombin III / Q000032:analysis* / Q000276:immunology; D020152:Antithrombin III Deficiency; D000939:Epitopes; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D011498:Protein Precursors / Q000032:analysis* / Q000276:immunology
D000939:Epitopes; D011498:Protein Precursors; D000990:Antithrombin III