Interferon-induced suppression of in vitro IgE biosynthesis in asthmatic children.
The effect of interferon on the in vitro IgE biosynthesis was studied in 22 asthmatic children. Peripheral blood mononuclear cells, T cells and B cells were treated with 400 IU human fibroblast interferon for six hours, washed, cultured for one week and the supernatant IgE concentrations were determined. The results showed (1) B cells were the targets for interferon effect as interferon-treated B cells produced much less IgE than did the untreated B cells and (2) the presence of normal T cells could protect the B cells from interferon-induced suppression of IgE synthesis. The results obtained in this study can be used to explain the depressed IgE levels after viral infections.
D001249:Asthma / Q000188:drug therapy* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004306:Dose-Response Relationship, Immunologic; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007165:Immunosuppression Therapy; D007372:Interferons / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000276:immunology
D007073:Immunoglobulin E; D007372:Interferons