Serum amylase and its isoenzymes in cases of viral hepatitis.
Serum amylase (SA) and its isoenzymes were studied in 9 control cases and 26 cases of Viral Hepatitis (VH). A significant rise in SA level was found in VH cases (Mean value--287.15 + 100.64) as compared to control cases (Mean value--155.56 + 28.57). The value was markedly increased in 8 cases with hepatic encephalopathy (Mean value--388 + 57.21). Isoenzymes of SA were estimated in all the cases by means of polyacrylamide gel electrophoresis and a direct saccharogenic assay of amylase activity. Besides two regular peaks (Pancreatic and Salivary fractions) a third peak (Slowest of all) was noticed in 4 out of 9 control cases (44.5%) and 19 out of 26 cases of VH (73.1%). Out of 8 cases who developed hepatic encephalopathy during the course, 7 had this peak (87.5%). SA levels and its isoenzymes level correlated well with the extent of hepatic damage (SGPT and Serum bilirubin levels). The possibility of hepatic origin of the third peak has been discussed.
D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000681:Amylases / Q000097:blood*; D001663:Bilirubin / Q000097:blood; D005260:Female; D006501:Hepatic Encephalopathy / Q000201:enzymology / Q000209:etiology; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology; D012463:Saliva / Q000201:enzymology
D007527:Isoenzymes; D000410:Alanine Transaminase; D000681:Amylases; D001663:Bilirubin