title: Effects of glutamate and aspartate on ataxic gait induced by 3-acetyl pyridine in rats.
abstract: The main purpose of this study was to examine the effects of intraventricular injections of glutamate and aspartate on the walking gait of rendered ataxic by the administration of 3-acetyl pyridine. Both amino acids significantly improved the walking gait of these animals. The effects of other substances known to have a stimulatory influence on locomotor activity in rats were also investigated. Amphetamine, apomorphine and thyrotropin releasing hormone (TRH) had no effect on the ataxic gait of 3-AP treated animals. Substance P significantly improved the gait of ataxic animals, but to a lesser extent than that seen with glutamate and aspartate.
mesh_terms: D000661:Amphetamine / Q000627:therapeutic use; D000818:Animals; D001058:Apomorphine / Q000627:therapeutic use; D001224:Aspartic Acid / Q000627:therapeutic use*; D001259:Ataxia / Q000139:chemically induced*; D005684:Gait; D005971:Glutamates / Q000627:therapeutic use*; D008297:Male; D011725:Pyridines / Q000037:antagonists & inhibitors*; D051381:Rats; D013373:Substance P / Q000627:therapeutic use; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use
chemical_list: D005971:Glutamates; D011725:Pyridines; C010835:3-acetylpyridine; D001224:Aspartic Acid; D013373:Substance P; D013973:Thyrotropin-Releasing Hormone; D000661:Amphetamine; D001058:Apomorphine