A model of bile duct hyperplasia in the rat induced by diethylnitrosamine and selective cytotoxicity.
Adult Wistar rats were subjected to a chemical carcinogenesis regimen involving initiation with diethylnitrosamine (DEN) and cytotoxic selection of initiated cells following partial hepatectomy. The livers of treated rats exhibited sequential changes of vacuolar degeneration and hepatocellular nodular hyperplasia up to 5 mth after completion of the experimental regimen. The hyperplastic nodules regressed slowly at that time. Cystic bile duct hyperplasia emerged with high frequency between 5 and 15 mth after completion of the regimen. The nitrosamine-initiated nodular and biliary hyperplasias could not be unequivocally accepted as preneoplastic lesions since frankly neoplastic transformation under these conditions was a relatively rare occurrence.
D000818:Animals; D001649:Bile Duct Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D003549:Cystic Duct / Q000187:drug effects / Q000473:pathology; D004052:Diethylnitrosamine / Q000633:toxicity*; D006965:Hyperplasia; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008297:Male; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000032:analysis
D009602:Nitrosamines; D004052:Diethylnitrosamine; D005723:gamma-Glutamyltransferase