Malabsorption and macroamylasemia. Response to gluten withdrawal.
A 36 year old woman presented with malabsorption and macroamylasemia. The macroamylase was characterized and shown to be a complex of pancreatic amylase and immunoglobulin A(IgA). The patient had the clinical and histologic features of adult celiac disease, and responded to a gluten-free diet. The macroamylase complex disappeared from the serum after gluten withdrawal, a hitherto unreported finding in the syndrome of malabsorption and hyperamylasemia.
D000328:Adult; D000681:Amylases / Q000097:blood* / Q000378:metabolism*; D005260:Female; D005983:Glutens / Q000009:adverse effects*; D006801:Humans; D007105:Immune Complex Diseases / Q000378:metabolism; D007143:Immunoglobulin Heavy Chains; D007421:Intestine, Small / Q000473:pathology; D008286:Malabsorption Syndromes / Q000097:blood / Q000201:enzymology / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D007143:Immunoglobulin Heavy Chains; D005983:Glutens; D000681:Amylases; C001663:macroamylase