Gastrointestinal mucosal gamma-glutamyl transpeptidase activity changes in different ulcer models of rat.
The experiments presented gave evidence that changes in gamma-glutamyl transpeptidase activity-under experimental circumstances-seem to be in close connection with gastro-intestinal ulceration. In the pre-ulcerative period in both gastric and duodenal ulcer models, the mucosal gamma-glutamyl transpeptidase activity is higher than normal, while in the definitive ulcerative stage the gastric gamma-glutamyl transpeptidase activity is significantly decreased but in the duodenum it remained on normal level. This phenomenon may reflect to a difference in the pathomechanism of the gastric and duodenal ulceration.
D000818:Animals; D004195:Disease Models, Animal; D004386:Duodenum / Q000201:enzymology; D005260:Female; D005753:Gastric Mucosa / Q000201:enzymology*; D007413:Intestinal Mucosa / Q000201:enzymology*; D010437:Peptic Ulcer / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000032:analysis*
D005723:gamma-Glutamyltransferase