Classification of cardioactive drugs in vivo by using programmed electrical stimulation in combination with monophasic action potential recordings at different pacing rates.
The effect of antiarrhythmic drugs on myocardial refractoriness may be due to changes either in Vmax of phase 0 or the phase of repolarization of the AP or both. By using programmed electrical stimulation in combination with MAP recordings at different pacing rates in the intact dog heart, it was possible to classify and to a certain extent to elucidate the mode of action of various cardioactive drugs in vivo.
D000070:Acebutolol / Q000494:pharmacology; D000120:Acecainide / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000145:classification / Q000494:pharmacology*; D001262:Atenolol / Q000494:pharmacology; D002090:Butyrophenones / Q000494:pharmacology; D002304:Cardiac Pacing, Artificial; D003201:Computers; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D002090:Butyrophenones; D001262:Atenolol; D000070:Acebutolol; D000120:Acecainide; D009543:Nifedipine; C008522:metylperon