[Effect of acute alcoholic intoxication on lipogenesis in the liver of rats].
Thirty minutes after a single ethanol injection (4 g/kg bw, i.p.) the activity of rat liver acetyl-CoA-synthetase and ATP-citralyase was decreased. Cholesterol synthesis estimated by label incorporation from 3H2O was increased whereas the synthesis of fatty acids remained at the control level. The possibility of alternative ways of acetyl-CoA production under the conditions of acute alcoholic intoxication is discussed.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000106:Acetate-CoA Ligase / Q000378:metabolism; D000105:Acetyl Coenzyme A / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D014316:Tritium; D014867:Water / Q000378:metabolism
D005227:Fatty Acids; D008055:Lipids; D010743:Phospholipids; D011768:Pyruvate Dehydrogenase Complex; D014867:Water; D014316:Tritium; D000105:Acetyl Coenzyme A; D001275:ATP Citrate (pro-S)-Lyase; D000106:Acetate-CoA Ligase
Vliianie ostroĭ alkogol'noĭ intoksikatsii na lipogenez v pecheni krys.