[Inhibitory effect of somatostatin on the secretion of duodenal gastrin].
This study covers 14 patients subjected to truncal Vagotomy + Antrectomy acc. BI, in order to ascertain whether somatostatin is capable of inhibiting duodenal gastrin release. Somatostatin infusion significantly inhibits the gastrinic response to a protein meal, but does not affect basal levels of the hormone. This suggests that facilitation of duodenal gastrin release after vagal section may be mediated by the reduced somatostatin release.
D004386:Duodenum / Q000378:metabolism*; D005260:Female; D005743:Gastrectomy / Q000379:methods; D005755:Gastrins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D008297:Male; D013004:Somatostatin / Q000494:pharmacology*; D014628:Vagotomy
D005755:Gastrins; D013004:Somatostatin
Effetto inibitorio della somatostatina sulla secrezione di gastrina duodenale.