[Effect of balanced anesthesia on lung histamine release in patients operated on for mitral heart defects with varying degrees of pulmonary hypertension].
The histamine concentration was estimated in the mixed venous and arterial blood in 28 patients with mitral defects subjected to closed mitral commissurotomy under balanced anesthesia. The oxygen content was determined simultaneously and the amount of blood shunting in the lungs was calculated by the oxygen method. It was established that the amount of histamine in the mixed venous blood coming to lungs was increased in patients with high degree lung hypertension. The balanced anesthesia itself did not influence the histamine concentration in the blood. The cessation of anesthesia, however, is followed by increased histamine concentration in the blood of patients with high lung hypertension. The process of blood shunting in the lungs is not controlled by histamine.
D000771:Anesthesia, Intravenous; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000601:surgery; D007432:Intraoperative Period; D008944:Mitral Valve Insufficiency / Q000097:blood* / Q000601:surgery; D011184:Postoperative Period; D011229:Preanesthetic Medication
D006632:Histamine
Vliianie sbalansirovannoĭ anestezii na vydelenie legkimi gistamina u bol'nykh, operirovannykh po povodu mitral'nykh porokov serdtsa s razlichnoĭ stepen'iu legochnoĭ gipetenzii.