Effects of dioxane on RNA synthesis in the rat liver.
The effect of dioxane on transcription was investigated. On intravenous administration of the lower dose (10 mg/rat) both RNA polymerase A and B activities were initially depressed but recovered after 1 h. A secondary effect on RNA polymerase A was observed but the enzyme activity recovered at 24 h when it was about 35% above control values whereas RNA polymerase B activity had achieved control values. With a higher dose (100 mg/rat) the pattern was similar but the suppressive effects were more pronounced - RNA polymerase B activity never attained control values during the times studied whereas there was no increase in RNA polymerase A activity at 24 h.
D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D004146:Dioxanes / Q000494:pharmacology*; D004147:Dioxins / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D004146:Dioxanes; D004147:Dioxins; D012313:RNA; D012321:DNA-Directed RNA Polymerases; C025223:1,4-dioxane