Prolonged hypnotic response to triazolam-cimetidine combination in an elderly patient.
An 82-year-old white female developed a 36-hour episode of unresponsiveness/drowsiness after a single dose of triazolam 0.5 mg in combination with cimetidine. This case illustrates the need for careful dose-titration of drug therapy in the elderly, particularly when a drug with the potential to impair drug metabolism is coadministered. Cimetidine, when coadministered with triazolam, may increase the intensity and duration of action of single doses of triazolam.
D000368:Aged; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D002927:Cimetidine / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008862:Microsomes, Liver / Q000378:metabolism; D013997:Time Factors; D014229:Triazolam / Q000009:adverse effects*
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D014229:Triazolam; D002927:Cimetidine