title: [Multiple endocrine neoplasms associated with Zollinger-Ellison syndrome and hyperparathyroidism].
abstract: We report the case of a 43 year old man with multiple endocrine neoplasia (Zollinger-Ellison syndrome-hyperparathyroidism) diagnosed during investigations for a severe ulcer with diarrhoea. The history suggested Zollinger-Ellison syndrome, especially as basal acid production and blood gastrin levels were high. Hypercalcaemia and low blood phosphate levels suggested hyperparathyroidism, which was confirmed by ultra-sound of the neck, showing two parathyroid adenomas. The aim of treatment was two-fold: suppress the hyperparathyroidism and treat the Zollinger-Ellison syndrome. The approach is surgical in most cases, but the tumour is often impossible to remove and total gastrectomy has become rare with the progress in anti-secretory therapy. When the tumour behind a case of Zollinger-Ellison syndrome cannot be found, complementary chemotherapy is indicated. Other endocrine lesions must always be sought and the family investigated to exclude Wermer syndrome.
mesh_terms: D000236:Adenoma / Q000150:complications / Q000601:surgery; D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use; D005743:Gastrectomy; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000209:etiology; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000150:complications*; D010282:Parathyroid Neoplasms / Q000150:complications / Q000601:surgery; D015043:Zollinger-Ellison Syndrome / Q000150:complications* / Q000628:therapy
chemical_list: D002927:Cimetidine
vernacular_title: Néoplasie endocrine multiple avec association syndrome de Zollinger-Ellison-hyperparathyroïdie.