Peripheral neuropathy with a syndrome of continuous motor unit activity.
A chronic alcoholic who had also been submitted to partial gastrectomy developed a syndrome of continuous motor unit activity responsive to phenytoin therapy. There were signs of minimal distal sensorimotor polyneuropathy. Symptoms of the syndrome of continuous motor unit activity were fasciculation, muscle stiffness, myokymia, impaired muscular relaxation and percussion myotonia. Electromyography at rest showed fasciculation, doublets, triplets, multiplets, trains of repetitive discharges and myotonic discharges. Trousseau's and Chvostek's signs were absent. No abnormality of serum potassium, calcium, magnesium, creatine kinase, alkaline phosphatase, arterial blood gases and pH were demonstrated, but the serum Vitamin B12 level was reduced. The electrophysiological findings and muscle biopsy were compatible with a mixed sensorimotor polyneuropathy. Tests of neuromuscular transmission showed a significant decrement in the amplitude of the evoked muscle action potential in the abductor digiti minimi on repetitive nerve stimulation. These findings suggest that hyperexcitability and hyperactivity of the peripheral motor axons underlie the syndrome of continuous motor unit activity in the present case.
D000437:Alcoholism / Q000150:complications* / Q000503:physiopathology; D004576:Electromyography; D006801:Humans; D006987:Hypesthesia / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects* / Q000502:physiology; D009431:Neural Conduction / Q000187:drug effects; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000503:physiopathology; D010672:Phenytoin / Q000627:therapeutic use; D011115:Polyneuropathies / Q000139:chemically induced* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects*
D010672:Phenytoin