Intestinal metaplasia with colonic-type sulphomucins in the gastric mucosa; its association with gastric carcinoma.
The occurrence of intestinal metaplasia with colonic-type sulphomucins: (abbreviated: s-IM or s-positive IM) in the gastric mucosa was studied in 125 patients with gastric carcinoma (GCA), 62 patients with pernicious anemia (PA), 301 and 183 first-degree relatives of GCA and PA patients, 406 outpatients and in 358 controls matched from a large population sample. The sulphomucins (s-mucins) were demonstrated histochemically in endoscopic biopsy specimens by using high iron diamine and Alcian blue (pH 1) methods. The prevalence of s-IM, especially the strongly s-positive IM, was significantly higher in GCA patients than in other series or controls of the same age group. Further, s-IM was significantly more common in PA patients and its prevalence higher in GCA relatives and outpatients than in other series or controls. The occurrence of s-IM was also age-dependent and dependent on the extent of IM. It was suggested that the occurrence of s-IM can be used as a sign of lesions that are more closely associated with GCA than IM is in general.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000423:Alcian Blue; D000752:Anemia, Pernicious / Q000473:pathology; D003959:Diamines; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009077:Mucins / Q000032:analysis*; D012737:Sex Factors; D013194:Staining and Labeling; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology*
D003959:Diamines; D009077:Mucins; C012564:sulfomucin; D000423:Alcian Blue