Heterogeneity of DNA deletion in gamma delta beta-thalassemia.
By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.
D001483:Base Sequence; D002872:Chromosome Deletion; D004262:DNA Restriction Enzymes; D005319:Fetal Hemoglobin / Q000235:genetics; D005796:Genes; D005914:Globins / Q000235:genetics*; D006441:Hemoglobin A / Q000235:genetics; D006801:Humans; D013789:Thalassemia / Q000145:classification / Q000235:genetics*
D005914:Globins; D006441:Hemoglobin A; D005319:Fetal Hemoglobin; D004262:DNA Restriction Enzymes