Bronchial provocation tests in atopic patients with allergen-specific IgG4 antibodies.
Atopic asthmatics who produce allergen-specific IgE antibodies develop an immediate reaction to bronchial provocation; those who produce allergen-specific IgG4 antibodies develop a delayed response; and those who produce both classes of antibody against the same allergen exhibit a dual response. Individual patients showed a variable immune response to different allergens, producing bot classes of antibody against one, but only IgE or IgG4 against others. These findings suggest that allergen-specific IgG4 antibodies are important in the production of severe asthma and probably atopic eczema as well.
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000276:immunology*; D001985:Bronchial Provocation Tests; D002648:Child; D004391:Dust; D000939:Epitopes; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008875:Middle Aged; D011058:Pollen / Q000276:immunology
D000485:Allergens; D004391:Dust; D000939:Epitopes; D007074:Immunoglobulin G; D007073:Immunoglobulin E