Inhibition of cholinergic histamine release in rat mast cells.
Adrenaline inhibits the acetylcholine-evoked histamine release from isolated purified rat mast cells, in a dose-dependent fashion. The inhibitory effect of adrenaline is reversed by preincubating the cells with a beta-blocker, aprenolol, but not by preincubating them with an alpha-blocker, phentolamine. These results were confirmed by observations using an electron microscope and they suggest that adrenaline inhibits the cholinergic histamine release from rat mast cells acting upoon beta-receptors.
D000109:Acetylcholine / Q000037:antagonists & inhibitors*; D000526:Alprenolol / Q000494:pharmacology; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats
D000526:Alprenolol; D000109:Acetylcholine; D004837:Epinephrine; D010646:Phentolamine