title: Acute parotitis and hyperamylasemia following whole-brain radiation therapy.
abstract: Parotitis, an infrequent, previously unreported complication of whole-brain radiation therapy, was observed in 4 patients. The acute symptoms, which include fever, dry mouth, pain, swelling, and tenderness, are accompanied by hyperamylasemia. Among 10 patients receiving whole-brain irradiation, 8 had serum amylase elevations without symptoms. Both acute parotitis and asymptomatic hyperamylasemia result from irradiation of the parotid glands.
mesh_terms: D000328:Adult; D000681:Amylases / Q000097:blood*; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D002528:Cerebellar Neoplasms / Q000532:radiotherapy / Q000556:secondary; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000532:radiotherapy; D008875:Middle Aged; D010306:Parotid Gland / Q000528:radiation effects*; D010309:Parotitis / Q000175:diagnosis / Q000209:etiology*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D000681:Amylases