[Effect of axoplasmic transport blocking and denervation on the activity and isomolecular spectra of some dehydrogenases in rat muscles].
Changes in the total activity and in the activity of isoenzyme forms of lactate dehydrogenase (EC 1.1.1.27), malate dehydrogenase (EC 1.1.1.37) and glucose-6-phosphate dehydrogenase (EC 1.1.1.49) are found in rat musculus gastrocnemius two weeks after blocking axoplasmic transport evoked by the application of 0.05 M colchicine solution to the ischiatic nerve. They are identical to those observed in surgical denervation. The changes in the isomolecular forms of the enzyme permit considering that the cell metabolism is affected by the axoplasmatic transport.
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects / Q000201:enzymology* / Q000294:innervation; D051381:Rats
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D003078:Colchicine
Vliianie blokirovaniia aksoplazmaticheskogo transporta i denervatsii na aktivnost' i izomolekuliarnye spektry nekotorykh degidrogenaz v myshtsakh krys.