title: Cytogenetic effects of pesticides. I. Induction of micronuclei in mouse bone marrow by the insecticide Dursban.
abstract: The induction of micronuclei in mouse bone marrow by the organophosphorous insecticide 'Dursban' was tested. 3 routes of administration were used for the pure insecticide: intraperitoneal, oral and dermal. The different routes of treatment with Dursban induced a statistically significant increase in the percentage of polychromatic erythrocytes over that of the control. Both intraperitoneal and oral treatments with the insecticide induced a high percentage of polychromatic erythrocytes with micronuclei, whereas dermal treatment did not induce micronuclei.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002467:Cell Nucleus / Q000187:drug effects*; D004390:Chlorpyrifos / Q000008:administration & dosage / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D007274:Injections, Intraperitoneal; D051379:Mice; D013194:Staining and Labeling
chemical_list: D004390:Chlorpyrifos