Serological cross-reactivity between products of separate I regions.
A B10.S(7R) anti-B10.S(9R) serum (anti-IJEkCd) contained, as expected, antibodies specific for the I-E-subregion-encoded determinant Ia.7. However, tests on recombinant haplotypes demonstrated a series of unexpected weak extrareactions which could be interpreted to be directed against antigenic determinants encoded in the I-A subregion of the H-2 complex. The same type of extrareaction was observed in eluates from I-As, I-Ek cells coated with A.TH anti-A.TL (I-As, I-Ek anti-I-Ak, I-Ek) serum. This reactivity in serum and eluates could be interpreted as cross-reactivity between products of the I-E and I-A subregions.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000235:genetics; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D008297:Male; D051379:Mice; D011995:Recombination, Genetic
D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera