51Cr-bleomycin, a new oncophilic radiopharmaceutical. I. Activity concentrations in transplantable tumours and organs-tissues of mice.
A method was developed for labeling bleomycin with 51Cr. The complex was administered to mice (Swiss and C57-B1/6) bearing 5 transplantable tumours: Ehrlich ascites tumour, NK/Ly lymphoma, Lewis lung carcinoma, melanoma B-16, and Sarcoma 180. Activity concentration in neoplasms, blood and numerous organs was determined 12, 24 and 48 hrs after injection. An identical procedure was applied using 58Co-bleomycin as a reference oncophilic substance. Tumour/non-tumor ratios exceeding substantially unity were found for blood, muscle and bone indicating preferential accumulation of both 58Co and 51Cr in all the neoplasms tested. The ratios were lower (by a factor 2-3) for 51Cr than for 58Co; however, it is postulated that the gamma-quantum energy of 51Cr which is higher than that of the commonly used 57Co, should offset to some degree this difference when scintigraphic tumour detection in a patient is to be attempted. In conclusion, clinical trials with 51Cr-bleomycin, which is cheaper than its 57Co-counterpart, appear warranted.
D000818:Animals; D001761:Bleomycin / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002860:Chromium Radioisotopes; D003037:Cobalt Radioisotopes; D007553:Isotope Labeling; D008175:Lung Neoplasms / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*; D012510:Sarcoma 180 / Q000378:metabolism; D014018:Tissue Distribution
D002860:Chromium Radioisotopes; D003037:Cobalt Radioisotopes; D001761:Bleomycin