[Possibility of reversing the action of the membranotropic antibiotic, gramicidin S, on bacteria].
The study on the possibility of eliminating gramicidin S from the bacterial cells which had adsorbed it showed that a part of the labeled antibiotic bound by the bacteria may be washed out with buffer or salines. When the cells which had adsorbed gramicidin S were treated with lecithin emulsion, a significant part of the bound antibiotic was transferred to the lecithin liposomes. This turned the gramicidin S effect to the cells: significant but not complete reduction of the membrane barrier properties and dehydrogenase reactivation. Elimination of gramicidin S also reduced the colony forming capacity in a part of the cells.
D000327:Adsorption; D001407:Bacillus / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002462:Cell Membrane / Q000187:drug effects; D004655:Emulsions; D004926:Escherichia coli / Q000187:drug effects; D006096:Gramicidin / Q000494:pharmacology*; D008081:Liposomes / Q000494:pharmacology; D008837:Micrococcus / Q000187:drug effects; D010713:Phosphatidylcholines / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
D004655:Emulsions; D008081:Liposomes; D010713:Phosphatidylcholines; D006096:Gramicidin
O vozmozhnosti obrashcheniia deĭstviia na bakterii membranotropnogo antibiotika gramitsidina S.