[Histochemical appearance of gamma-glutamyltranspeptidase in the rat liver after transplacental exposure to diethylnitrosamine and postnatal administration of phenobarbital].
Phenobarbital administration during 7 weeks after partial hepatectomy is shown to be a sufficient promoting factor for induction of hyperplastic nodules in the rat liver initiated by the single DENA injection to pregnant rats. Histochemical distribution of gamma-glutamyltranspeptidase was a marker for identification of hyperplastic nodules.
D000818:Animals; D004052:Diethylnitrosamine; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006498:Hepatectomy; D006651:Histocytochemistry; D006965:Hyperplasia; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D010634:Phenobarbital / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000096:biosynthesis*
D004052:Diethylnitrosamine; D005723:gamma-Glutamyltransferase; D010634:Phenobarbital
Gistokhimicheskoe vyiavlenie aktivnosti gamma-gliutamiltranspeptidazy v pecheni krys posle transplatsentarnogo vozdeĭstviia DENA i postnatal'nogo vvedeniia fenobarbitala.