title: Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin.
abstract: Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.
mesh_terms: D000036:Abrin; D000818:Animals; D001370:Axonal Transport; D037102:Lectins; D051379:Mice; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D037121:Plant Lectins; D010940:Plant Proteins; D012183:Retrograde Degeneration; D054790:Ribosome Inactivating Proteins, Type 2; D012276:Ricin
chemical_list: D037102:Lectins; D037121:Plant Lectins; D010940:Plant Proteins; D054790:Ribosome Inactivating Proteins, Type 2; D000036:Abrin; C016004:modeccin; D012276:Ricin