Alprazolam-related digoxin toxicity.
An elderly woman developed a high serum digoxin concentration resulting in toxicity when alprazolam was added to her digoxin therapy. The reduced renal clearance of digoxin is postulated as the mechanism for this interaction.
D000368:Aged; D000525:Alprazolam; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000378:metabolism / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001569:Benzodiazepines / Q000009:adverse effects* / Q000378:metabolism / Q000494:pharmacology; D004077:Digoxin / Q000009:adverse effects* / Q000097:blood / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D004077:Digoxin; D000525:Alprazolam