[Cryptal origin of the intestinal secretion induced in rats by prostaglandin El. Evolution of secretion after a single injection of 5-fluorouracil].
The intestinal secretions induced by an intrajejunal perfusion of prostaglandin E1 (PGE1) at the rate of 24 gamma/min in anaesthetized male Wistar rats, weighing 200-200 g, were studied during 6 days after a single injection of an antimitotic agent, the 5-fluorouracil (5-FU, 40 mg/kg). 5-FU induced changes in the structure of the intestinal mucosa. The modifications observed in the intestinal secretions of water and sodium induced by PGE1 suggest that these secretions might (a) originate from crypts; (b) be partly reabsorbed by villi. Concerning the endogenous secretions, the intestinal mucosa might act as a secretion-reabsorption system.
D000527:Alprostadil; D000818:Animals; D005472:Fluorouracil / Q000494:pharmacology*; D007583:Jejunum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011458:Prostaglandins E; D000527:Alprostadil; D005472:Fluorouracil
Origine cryptique de la sécrétion intestinale induite chez le rat par la prostaglandine E1. Evolution des sécrétions après une injection unique de 5-fluorouracil.