Further characterization of natural killer cells induced by Kunjin virus.
The natural killer (NK) cell induced one to two days after Kunjin virus infection of BALB/c mice is cytotoxic for a wide range of syngeneic, allogeneic and xenogeneic cell lines. It is also weakly cytotoxic for some non-malignant cells including mouse fibroblasts, macrophages and thymocytes, but not lymph node cells. Levels of lysis of non-tumour target cells are dependent on their genotype. Furthermore, malignant cell lines may become resistant following transplantation in vivo then susceptible again after culture in vitro. The virus-induced NK cell is elicited as readily in athymic (nude) as in normal mice. X-irradiation inhibits its development if administered prior to infection. It is labile on culture at 37 degrees. The cell carries Fc receptors but its NK activity is not antibody-dependent.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D007372:Interferons / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000528:radiation effects; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology; D011961:Receptors, Fc / Q000032:analysis; D014035:Togaviridae / Q000276:immunology*
D000906:Antibodies; D011961:Receptors, Fc; D007372:Interferons