title: [Further research on the detoxifying effect of RNA].
abstract: Type A Cl. perfringens toxin caused necrosis in guniea-pigs and killed mice. Sodium nucleinate, administered orally to these animals simultaneously with the injection of the toxin and 2 hours later significantly prevented dermonecrosis in guinea-pigs and death in mice, as well as the development of pathomorphological changes in the liver, the kidneys and the spleen, the fatty degeneration of hepatocytes and disturbances in nucleic acid metabolism in these cells.
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000506:poisoning; D003016:Clostridium perfringens; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D051379:Mice; D009336:Necrosis; D009696:Nucleic Acids / Q000627:therapeutic use*; D012313:RNA / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects
chemical_list: D001427:Bacterial Toxins; D009696:Nucleic Acids; D012313:RNA; C013683:sodium nucleinate
vernacular_title: Dal'neĭshie issledovaniia po detoksitsiruiushchemu éffektu RNK.