Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats.
In ventral prostate tissues of adult castrated rats, delta-9-tetrahydrocannabinol (THC) at 10 mg/kg for 7 days counteracted the testosterone-induced changes of (i) DNA, RNA and protein content, (ii) the tartrate-insensitive form of acid phosphatase, and (iii) the isoenzyme variant of acid phosphatase associated with the secretory type enzyme. These results indicate that THC acts anti-androgenically and directly at the level of male accessory sex organs.
D000135:Acid Phosphatase / Q000378:metabolism; D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D004247:DNA / Q000378:metabolism; D013759:Dronabinol / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D008297:Male; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D013739:Testosterone / Q000494:pharmacology
D000726:Androgen Antagonists; D011506:Proteins; D013739:Testosterone; D012313:RNA; D013759:Dronabinol; D004247:DNA; D000135:Acid Phosphatase