Cell surface glycoproteins as markers in monitoring in vitro differentiation of embryonal carcinoma cells.
Various cell surface markers, such as SSEA-1, SSEA-3, Forssman, I, i, brushin, FT-1, PNA receptors, FBP receptors, and DBA receptors, are expressed in certain subpopulations of early embryonic cells. They are useful in monitoring the process of in vitro differentiation of embryonal carcinoma (EC) cells. For example, SSEA-1 is a marker of EC cells, whereas DBA receptors are markers of endoderm cells and quasi-nullipotent EC cells. An important carrier of the developmentally regulated cell surface markers is embryoglycan, which is a class of glycoprotein-bound large carbohydrates and has the lactosaminoglycan-type structure.
D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D002471:Cell Transformation, Neoplastic; D006017:Glycolipids / Q000276:immunology; D006023:Glycoproteins / Q000378:metabolism*; D016256:Lewis X Antigen; D011134:Polysaccharides / Q000276:immunology; D011975:Receptors, Mitogen / Q000378:metabolism; D013724:Teratoma / Q000473:pathology*
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; C027654:Dolichos biflorus lectin receptor; D006017:Glycolipids; D006023:Glycoproteins; D016256:Lewis X Antigen; D011134:Polysaccharides; D011975:Receptors, Mitogen; C045474:embryoglycan; C038223:peanut agglutinin receptor