Is vasoactive intestinal peptide an inhibitory transmitter in the circular but not the longitudinal muscle of guinea-pig colon?
Circular muscle strips of guinea-pig isolated colon relaxed with vasoactive intestinal peptide or peptide histidine methionine, whereas the longitudinal muscle contracted. The non-adrenergic-non-cholinergic inhibitory nerves may therefore be different in these two muscle layers.
D000818:Animals; D003106:Colon / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D010451:Peptide PHI; D010455:Peptides / Q000494:pharmacology; D011498:Protein Precursors / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology / Q000502:physiology*
D018377:Neurotransmitter Agents; D010451:Peptide PHI; D010455:Peptides; D011498:Protein Precursors; D014660:Vasoactive Intestinal Peptide