Interleukin 2 regulates immune interferon (IFN gamma) production by normal and suppressor cell cultures.
A Lyt-2+ lymphocyte is responsible for immune interferon (IFN gamma) production in mitogen-stimulated  mouse spleen cell cultures. A Lyt-1+ helper cell is required for the induction of IFN gamma. Interleukin 2 (IL 2) can specifically replace the Lyt 1 cell requirement. IL 2 will also abrogate suppressor cell inhibition of IFN gamma production. IFN gamma production appears to be regulated by a dynamic interaction between helper cells (source of IL 2), suppressor cells (absorption of IL 2?) and IFN gammna-producer cells.
D000818:Animals; D000950:Antigens, Ly; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002478:Cells, Cultured; D004768:Enterotoxins / Q000494:pharmacology; D005260:Female; D007372:Interferons / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008211:Lymphocyte Cooperation; D008222:Lymphokines / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013211:Staphylococcus aureus; D013601:T-Lymphocytes / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism*
D000950:Antigens, Ly; D000961:Antilymphocyte Serum; D004768:Enterotoxins; D007376:Interleukin-2; D008222:Lymphokines; D007372:Interferons