title: Histiocytosis X with unusual skin symptoms.
abstract: A 4-year-old boy with skin symptoms resembling verruca plana juvenile was observed. The light- and electron-microscopic picture showed the typical features of histiocytosis X (Letterer-Siwe syndrome). Beside the skin manifestations some less dense areas in the skull bones were found by X-ray examination. Vinblastine and prednisolone treatment for one year resulted in complete remission.
mesh_terms: D002675:Child, Preschool; D006644:Histiocytes / Q000648:ultrastructure; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D009940:Organoids / Q000648:ultrastructure; D011239:Prednisolone / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D014747:Vinblastine; D011239:Prednisolone