Photosensitization and the nervous system in the planarian Dugesia gonocephala. A histochemical, ultrastructural and behavioral investigation.
Photosensitization phenomena may be induced in planarias by eosin and hematoporphyrin, and as a result, dopamine agonistic behavior ("screw-like hyperkinesia") is set up in the animal. Histochemical, ultrastructural and pharmacological investigations have shown that this hyperkinesia is of post-synaptic origin in eosin photosensitization, and of pre-synaptic origin in hematoporphyrin photosensitization. The authors suggest an hypothesis to explain the different activity of the two photosensitizers, and discuss the validity of the experiment with regard to human porphyria.
D000818:Animals; D004801:Eosine Yellowish-(YS) / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006415:Hematoporphyrins / Q000494:pharmacology; D008027:Light / Q000009:adverse effects*; D008854:Microscopy, Electron; D009068:Movement; D009417:Nerve Tissue / Q000187:drug effects / Q000528:radiation effects*; D010932:Planarians / Q000033:anatomy & histology / Q000528:radiation effects*; D012110:Reserpine / Q000494:pharmacology; D014419:Turbellaria / Q000528:radiation effects*
D006415:Hematoporphyrins; D012110:Reserpine; D006220:Haloperidol; D004801:Eosine Yellowish-(YS)