[D-Penicillamine effect on collagen synthesis and structural maintenance Red Sirius staining with polarized-light examination. The value of this staining in cases of collagen diseases (author's transl)].
A severe systemic sclerodermia has been treated by D-Penicillamine. A pathological study before and after treatment showed important changes of the collagen structure. The soluble or foetal collagen fraction is enhanced. By the Red-Sirius staining with polarized light examination of the bundles of foetal collagen are green and bright. Then, this staining appears as a marker of collagen structures.
D000328:Adult; D003094:Collagen; D003238:Connective Tissue / Q000187:drug effects; D006801:Humans; D008297:Male; D008859:Microscopy, Polarization; D010396:Penicillamine / Q000494:pharmacology* / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000188:drug therapy / Q000473:pathology*; D012867:Skin / Q000187:drug effects*; D013194:Staining and Labeling
D003094:Collagen; D010396:Penicillamine
Appréciation de l'effet de la D-Pénicillamine sur la synthèse et le maintien de la structure collagène, grâce à la coloration histologique par le Rouge Sirius examinée en lumière polarisée. Discussion de la valeur de cette coloration en pathologie du collagène.