title: A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists.
abstract: Two selective H2-histamine agonists, dimaprit and impromidine, have been tested for their action on histamine release from human basophils and rat mast cells. IgE-mediated basophil histamine release was inhibited by stimulation of histamine H2-receptors. However, differences between the actions of both dimaprit and impromidine were noticed. Both impromidine and dimaprit had no specific effect on 48/80-induced histamine release from rat mast cells, although the latter in higher concentrations either slightly increased spontaneous histamine release or non-specifically inhibited compound 48/80-induced release. The results are consistent with the view that activation of adenylate cyclase via H2-histamine receptors might be an important regulatory mechanism of histamine release from human basophils but not from rat mast cells.
mesh_terms: D000485:Allergens / Q000494:pharmacology; D000707:Anaphylaxis / Q000378:metabolism*; D001491:Basophils / Q000276:immunology*; D017259:Dimaprit; D006146:Guanidines / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D017446:Impromidine; D066298:In Vitro Techniques; D008407:Mast Cells / Q000276:immunology; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000502:physiology*; D013890:Thiourea / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D000485:Allergens; D006146:Guanidines; D007093:Imidazoles; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D003189:p-Methoxy-N-methylphenethylamine; D017446:Impromidine; D013890:Thiourea; D017259:Dimaprit