Antigen-specific factors produced by carrier-primed New Zealand Black mice.
We studied antigen-specific suppression in NZB and B/W mice to investigate immunoregulatory circuits associated with autoimmune disease. Young NZB and B/W mice produced ample suppressor factor, and acceptor cells were present even in older mice. A low m.w. antigen-specific enhancing factor capable of augmenting the secondary in vitro IgG antibody response to DNP was found. These results indicate the complexity of immunoregulation in these autoimmune-susceptible mice.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D002352:Carrier Proteins / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology; D000939:Epitopes; D006241:Haptens; D006433:Hemocyanins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D002352:Carrier Proteins; D004136:Dinitrobenzenes; D000939:Epitopes; D006241:Haptens; D006433:Hemocyanins