A substance P projection to the hippocampus.
Electrolytic lesions of the septal area in the rat resulted in a major decrease in the activity of choline acetyltransferase in the hippocampus, consistent with the interruption of the septo-hippocampal cholinergic pathway. These lesions also significantly decreased the levels of substance P in the hippocampus. It is suggested that a substance P projection to the hippocampus arises in or passes through the septal area.
D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D012688:Septum Pellucidum / Q000502:physiology*; D013373:Substance P / Q000032:analysis*
D013373:Substance P; D002795:Choline O-Acetyltransferase