title: [Antiandrogen therapy of acne, falling hair and hirsutism (author's transl)].
abstract: Hormonal influences give rise to hirsutism and may encourage the appearance of seborrhea, acne and falling hair. Androgenically active processes in the cells of the end organs (e. g. sebaceous glands, hair roots) and in the endocrine regulation center may also be responsible for androgenic manifestations in women such as excretion of androgens by suprarenals and ovaries as well as its metabolization and final elimination. The central inhibiting effects of large doses of estrogen or gestagen have been taken advantage of since the sixties with varying therapeutic success. Advances in the treatment were only brought by the development of antiandrogenic progestogens and finally the synthesis of the "antiandrogen" cyproterone acetate in particular which, when selectively applied with critical consideration of the clinical symptoms, brings about a satisfactory therapeutic result for the cosmetically sensitive woman.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000505:Alopecia / Q000188:drug therapy*; D001667:Binding, Competitive; D002715:Chlormadinone Acetate / Q000627:therapeutic use; D003534:Cyproterone / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006628:Hirsutism / Q000188:drug therapy*; D006801:Humans; D008535:Megestrol / Q000627:therapeutic use; D011374:Progesterone / Q000627:therapeutic use; D011944:Receptors, Androgen
chemical_list: D004967:Estrogens; D011944:Receptors, Androgen; D002715:Chlormadinone Acetate; D011374:Progesterone; D003534:Cyproterone; D008535:Megestrol
vernacular_title: Antiandrogene Behandlung bei Akne, Haarausfall und Hirsutismus.