Production of primate D-type virus interspecies-specific antigen during cocultivation of human breast fibroadenoma cells with bat lung cells.
Nine human breast fibroadenomas, initially negative for D-type retrovirus interspecies-specific antigen, do not produce that antigen during 6 months of cocultivation with bat lung cells. However, 3 out of 5 human breast fibroadenomas, already positive for D-type virus interspecies-specific antigen before cultivation, are able to induce a transient D-type retrovirus interspecies-specific antigen production after 3 to 4 months of cocultivation with bat lung cells. The antigen is detectable both in cocultivated cells and in pellets sedimented from the coculture fluid. It is concluded that D-type retroviruses are associated with human breast fibroadenomas.
D000232:Adenofibroma / Q000276:immunology / Q000382:microbiology*; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D001943:Breast Neoplasms / Q000276:immunology / Q000382:microbiology*; D002478:Cells, Cultured; D002685:Chiroptera; D000939:Epitopes; D006801:Humans; D008168:Lung / Q000382:microbiology; D008297:Male; D012192:Retroviridae Infections / Q000276:immunology / Q000382:microbiology*; D013045:Species Specificity
D000956:Antigens, Viral; D000939:Epitopes