title: Effects of adrenaline and alpha adrenergic antagonists on platelet aggregation in whole blood: evaluation of electrical impedance aggregometry.
abstract: The effects of adrenaline and alpha adrenergic antagonists on platelet aggregation in whole blood were assessed by electrical impedance. These effects were then compared to those found in platelet rich plasma assessed by both optical and impedance methods. Our data demonstrate a number of difficulties in attempting to measure platelet responsiveness by electrical impedance and re-emphasise the need for caution in interpretation of in vitro platelet aggregation studies in terms of their clinical relevance.
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D004088:Dihydroergotoxine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010646:Phentolamine / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011224:Prazosin / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D000317:Adrenergic alpha-Antagonists; D004088:Dihydroergotoxine; D015016:Yohimbine; D011224:Prazosin; D004837:Epinephrine; D010646:Phentolamine