Effects of kinins, kallikrein and its inhibitor on certain indices of cell-mediated immunity and humoral immunity in rabbits.
The experiments were carried out on 54 rabbits in 9 groups of 6 animals each: group I -- controls, groups II, III, IV -- bradykinin i.v., groups V, VI, VII -- Depot-Kallikrein i.m. every other day for 3 weeks, groups VIII and IX -- Traskolan (trasylol) i.v. four times at intervals of 1 or 12 hours. The determined indices of cell-mediated and humoral immunity included: phagocytic activity of the reticuloendothelial system and peripheral blood leucocytes and their leukergic adhesiveness, haemagglutinin and haemolysin levels, serum complement titre, and the number of cells forming rosettes (RFC) or plaques (PFC) in the blood and spleen. These indices were determined 15 minutes, 3 and 24 hours after bradykinin administration, after 1, 2 and 3 weeks of kallikrein administration, and 1 or 12 hours after the last dose of Traskolan. Most determined indices showed always some fall. Only the phagocytic activity of the reticuloendothelial system was moderately increased in all groups, and in the bradykinin group leucocyte phagocytosis was increased slightly while their leukergic reaction was increased very strongly.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D007611:Aprotinin / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology*; D003167:Complement Activation / Q000187:drug effects; D006388:Hemagglutinins / Q000096:biosynthesis; D006460:Hemolysin Proteins / Q000096:biosynthesis; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D012397:Rosette Formation
D006388:Hemagglutinins; D006460:Hemolysin Proteins; D007611:Aprotinin; D007610:Kallikreins; D001920:Bradykinin