title: Intermolecular interactions of gramicidin A' transmembrane channels incorporated into lysophosphatidylcholine lipid systems.
abstract: Fluorescence studies are reported on gramicidin A' incorporated into lysophosphatidylcholine phospholipid structures. The shift in the emission maximum during incorporation and the quenching of fluorescence by I- and by acrylamide of the incorporated state obtained after prolonged heating are consistent with the presence of the channel state comprised of two single-stranded beta 6 -helices associated head-to-head (formyl end-to-formyl end). The quantum yield for the incorporated state, when gramicidin A' is within the lipid matrix, is very low and indicates the occurrence of intermolecular Trp-Trp interactions. Possible interactions between channels within the lipid matrix are discussed utilizing Trp-Trp contacts.
mesh_terms: D006096:Gramicidin; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D008081:Liposomes; D008244:Lysophosphatidylcholines; D008823:Micelles; D008958:Models, Molecular; D011487:Protein Conformation; D011789:Quantum Theory; D013050:Spectrometry, Fluorescence
chemical_list: D007473:Ion Channels; D008081:Liposomes; D008244:Lysophosphatidylcholines; D008823:Micelles; D006096:Gramicidin