title: The role of host responses in the recovery of mice from Sendai virus infection.
abstract: The antiviral responses in mice to intranasal inoculation with Sendai virus are described. To investigate the relative importance of the humoral, cell-mediated and interferon responses, the pathogenesis of this infection was studied in animals which were immunocompetent, T cell-deprived or immunosuppressed with cyclophosphamide. Treatment with cyclophosphamide converted the mild, self-limiting infection observed in immunocompetent mice into a severe and frequently lethal pneumonic disease. This was associated with an enhanced interferon response but no detectable antibody or cell-mediated immune response. T cell-deprived mice suffer an infection of intermediate severity associated with an increased interferon response, a normal humoral immune response and no cell-mediated immune response. The implications of these results in relation to the role of the antiviral responses in recovery from Sendai virus infection are discussed.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D007165:Immunosuppression Therapy; D007372:Interferons / Q000096:biosynthesis*; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D003520:Cyclophosphamide; D007372:Interferons