[Comparison in genetically hyperlipoproteinemic and normal rats of the secretion of lipids synthesized by isolated livers perfused with isotopic oleic acid and glycerol at high concentrations].
After perfusing isolated livers of Zucker fa/fa ad Fa/- rats with loads of [9,10-3H2] oleic acid (346 mumol) and [1-14C] glycerol (115 mumol), glycerol inhibited the hepatic secretion of triacylglycerol and phospholipids in the two groups of rats. However, the amount of acylglycerols synthetized from these exogenous substrates is slightly higher in the obese rats than in the normal rats. These results suggest that glycerol, present in high amounts in blood of fa/fa rats, failed to regulate triacylglycerols and phospholipids secretion.
D000818:Animals; D002250:Carbon Radioisotopes; D005990:Glycerol / Q000378:metabolism*; D006951:Hyperlipoproteinemias / Q000235:genetics / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D009829:Oleic Acids / Q000378:metabolism*; D010477:Perfusion; D010743:Phospholipids / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D014280:Triglycerides / Q000096:biosynthesis / Q000378:metabolism*; D014316:Tritium
D002250:Carbon Radioisotopes; D009829:Oleic Acids; D010743:Phospholipids; D014280:Triglycerides; D014316:Tritium; D005990:Glycerol
Comparaison chez des rats génétiquement hyperlipoprotéinémiques et des rats normaux des sécrétions des lipides synthétisés par les foies isolés et perfusés par des doses de charge d'acide oléque et de glycérol marqués.