Further studies on anti-tumor activity of adenovirus fibre protein on murine sarcoma tumours.
The present study demonstrates that subcutaneous injection of purified adenovirus 12 fibre protein (FP) to 4-week-old Balb/c mice, 4, 2 and 1 day(s) before intramuscular injection of murine sarcoma virus (MSV-M) or 2 and 1 day before and 1 day after MSV-M injection causes significant inhibition of tumour growth (P less than 0.001). The evidence suggests that treatment with FP leading to tumour inhibition is due to neither an interferon mechanism nor to inhibition of virus multiplication of FP in the reticuloendothelial system. It is postulated that immune functions, probably against MSV-induced cell antigens, might be the critical mechanisms underlying inhibition of tumour growth.
D000260:Adenoviruses, Human / Q000032:analysis*; D000818:Animals; D000917:Antibody Formation; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000276:immunology; D002213:Capsid / Q000494:pharmacology; D036022:Capsid Proteins; D007372:Interferons / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D009053:Sarcoma Viruses, Murine / Q000254:growth & development; D012513:Sarcoma, Experimental / Q000382:microbiology / Q000517:prevention & control*; D014764:Viral Proteins / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D000970:Antineoplastic Agents; D036022:Capsid Proteins; D014764:Viral Proteins; C018315:hexon capsid protein, Adenovirus; D007372:Interferons