Presynaptic location and axonal transport of beta 1-adrenoreceptors in the rat brain.
Interruption of the ascending noradrenergic neurons of the locus coeruleus in the rat forebrain with 6-hydroxydopamine produced a progressive accumulation, proximal to the lesion, of tritiated dihydroalprenolol binding activity over 2 days. This accumulation could be blocked by interrupting the neurons closer to their cell bodies. Competitive binding studies with the beta 2 agonist Zinterol suggested that the accumulated beta-receptors were primarily of the beta 1 subtype. These results suggest that, in the rat brain, some beta 1-adrenoreceptors are located in presynaptic, noradrenergic locus coeruleus neurons and are transported in their axons.
D000320:Adrenergic Fibers / Q000378:metabolism*; D000818:Animals; D001340:Autonomic Nerve Block; D001370:Axonal Transport; D001369:Axons / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D004082:Dihydroalprenolol / Q000378:metabolism; D004983:Ethanolamines / Q000378:metabolism; D006892:Hydroxydopamines / Q000494:pharmacology; D007032:Hypothalamus, Anterior / Q000378:metabolism; D008125:Locus Coeruleus / Q000378:metabolism; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D004983:Ethanolamines; D006892:Hydroxydopamines; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D017981:Receptors, Neurotransmitter; D004082:Dihydroalprenolol; C002904:zinterol; D016627:Oxidopamine