title: Inhibition of arachidonic acid oxidation in vitro by vehicle components.
abstract: In this work, we observed that several vehicle components which are complex lipids inhibited the oxidation of arachidonic acid in the oxygen monitor assay. Inhibition of oxygen consumption in this assay, a relatively non-specific finding, may reflect inhibition of lipoxygenase and/or prostaglandin synthetase activity or possible sequestration of arachidonic acid. Theoretically, similar effects could occur in vivo. Consideration should be given to the formulation of vehicles which maximize the anti-inflammatory effects of vehicle components.
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002417:Cattle; D066298:In Vitro Techniques; D008055:Lipids / Q000494:pharmacology*; D008084:Lipoxygenase / Q000502:physiology; D010084:Oxidation-Reduction; D014677:Pharmaceutical Vehicles / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology
chemical_list: D001095:Arachidonic Acids; D008055:Lipids; D014677:Pharmaceutical Vehicles; D016718:Arachidonic Acid; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases