Pathology of experimental infection with Brugia malayi in ferrets: comparison with occult filariasis in man.
Ferrets experimentally infected with Brugia malayi (subperiodic strain) developed eosinophilia at patency and usually became amicrofilaremic. Ferrets necropsied within 3 months after becoming amicrofilaremic had granulomas and focal reactions to degenerating microfilariae in their livers, lungs and lymph nodes essentially identical to those of tropical eosinophilia. Four of 7 ferrets that received multiple inoculations of larvae, developed edema of the inoculated paw and leg after becoming amicrofilaremic and 6 of these 7 ferrets had granulomatous lymphangitis and lymphadenitis of inoculated limbs but not the lesions of lung and liver characteristic of occult infection.
D000818:Animals; D002009:Brugia; D002335:Carnivora; D004195:Disease Models, Animal; D004487:Edema; D004802:Eosinophilia; D005289:Ferrets; D005368:Filariasis / Q000473:pathology*; D006099:Granuloma / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008205:Lymphangitis / Q000473:pathology; D008208:Lymphatic System / Q000473:pathology