[Effect of 5-fluorouracil on the enzymatic activity of the pancreas and blood serum of rats with acute pancreatitis].
The effect of 5-fluorouracil on the activity of pancreatic enzymes was studied in rats with acute pancreatitis. 5-Fluorouracil was injected intraperitoneally in a dose of 4.5 mg per 100 g body weight. Pancreatic transaminidase as well as serum alpha-amylase and trypsin levels decreased starting from 3--6h after the induction of acute pancreatitis. 5-Fluorouracil inhibited RNA and DNA synthesis and blocked the synthesis of pancreatic enzymes.
D000208:Acute Disease; D000818:Animals; D004247:DNA / Q000037:antagonists & inhibitors; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D010195:Pancreatitis / Q000188:drug therapy* / Q000201:enzymology; D012313:RNA / Q000037:antagonists & inhibitors; D051381:Rats
D012313:RNA; D004247:DNA; D005472:Fluorouracil
Vliianie 5-ftoruratsila na aktivnost' nekotorykhfermentov podzheludochnoĭ zhelezy i syvorotki krovi krys pri ostrom pankreatite.