Effects of phenytoin on amygdaloid kindled seizures in the rat.
The effects of oral phenytoin (0.25 g/kg) on the evolution of amygdaloid seizures were investigated using the kindling technique in rats. By utilizing low intensity stimulation at threshold for after-discharge, it was found that phenytoin produced a 23% increase in threshold for after-discharge and generalized seizures in fully kindled rats with blood levels in the human therapeutic range. Although half of the animals demonstrated a block of after-discharge after phenytoin was started when the stimulation intensity was increased, the phenytoin animals developed generalized seizures in the same manner as controls.
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000517:prevention & control*
D010672:Phenytoin