Levels of carbenicillin in serum and prostatic tissue after intravenous administration in patients with benign prostatic hyperplasia.
Carbenicillin (CB-PC) was administered intravenously (5 gm over one-half hour) to 25 patients suffering form benign prostatic hyperplasia. Prostatic biopsies and sera were obtained one, two, three, four, and five hours later for histology and biochemical analyses of the serum and prostatic tissue levels of CB-PC. The serum and prostatic tissue levels of carbenicillin attained were sufficient to eradicate gram-negative bacteria within the five time intervals studied. The ratio of prostatic tissue level of CB-PC to the serum level of this agent increased in proportion to the grading of round cell infiltration of the prostatic tissue. The results of this study point to the clinical usefulness of CB-PC in the treatment of chronic and acute prostatitis.
D002228:Carbenicillin / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D011471:Prostatic Neoplasms / Q000378:metabolism
D002228:Carbenicillin