Changes of nucleic acid and protein synthesis in hypertrophied guinea-pig heart during intermittent hypoxia.
The effect of intermittent normobaric hypoxia on nucleic acid and protein synthesis of guinea-pig heart was studied. De novo synthesis of purine nucleotides, of RNA and DNA, as well as RNA polymerase activities and protein synthesis, increased in the heart right ventricles of hypoxic animals compared to the controls. These results suggest an activation of cellular genetic apparatus with an increase of nucleic acid and protein syntheses during the compensatory processes following hypoxia.
D000818:Animals; D006332:Cardiomegaly / Q000150:complications / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005561:Formates / Q000378:metabolism; D006168:Guinea Pigs; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*
D005561:Formates; C030544:formic acid; D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D007930:Leucine