Effects of flavonoids and transitional metal cations on antigen-induced histamine release from human basophils.
Structure-activity relationship studies have been performed on the inhibition of antigen-induced histamine release from human basophils by various naturally occurring flavonoids. Quercetin was the most active compound. Of the transitional metal ions, Cu2+ most effectively blocked the inhibitory activity of quercetin, possibly through a chelation mechanism.
D000941:Antigens; D001491:Basophils / Q000187:drug effects / Q000378:metabolism*; D003300:Copper / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008670:Metals / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000941:Antigens; D005419:Flavonoids; D008670:Metals; D003300:Copper