Remarks on the spatial structure of the external segment of glycophorin A.
A model of the possible structure of the N-terminal part of glycophorin A is suggested. According to this model, in isotonic salt solutions of physiologic pH the peptide chain of the extracellular segment of glycophorin A is arranged parallel to the membrane with its carbohydrate side chains orientated perpendicularly to the lipid bilayer. Decreases of the pH or of the ionic strength result in a structural remodeling of this segment, there is at the very least a partial detachment of the glycosylated peptide backbone from the membrane's lipid layer.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006021:Glycophorins; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D009994:Osmolar Concentration; D010443:Peptide Chain Termination, Translational; D011487:Protein Conformation; D012795:Sialoglycoproteins
D006021:Glycophorins; D012795:Sialoglycoproteins