Biochemical basis for the differential sensitivity of human T- and B-lymphocyte lines to 5-fluorouracil.
D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D001711:Biotransformation; D002460:Cell Line; D005468:Fluorodeoxyuridylate / Q000096:biosynthesis; D005472:Fluorouracil / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D009962:Orotate Phosphoribosyltransferase / Q000378:metabolism; D009963:Orotic Acid / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D013939:Thymidine Phosphorylase / Q000378:metabolism; D014529:Uridine / Q000378:metabolism; D014543:Uridine Phosphorylase / Q000378:metabolism; D014544:Uridine Triphosphate / Q000031:analogs & derivatives / Q000096:biosynthesis
D005468:Fluorodeoxyuridylate; C025635:5-fluorouridine 5'-triphosphate; D009963:Orotic Acid; D012313:RNA; D009962:Orotate Phosphoribosyltransferase; D014543:Uridine Phosphorylase; D013939:Thymidine Phosphorylase; D005472:Fluorouracil; D014544:Uridine Triphosphate; D014529:Uridine