Ontogeny of B lymphocyte function. VIII. Failure of thymus cells from aged donors to induce the functional maturation of B lymphocytes from immature donors.
The role of thymus cells in mediating a step in the ontogeny of the capacity of the B cell population to produce a heterogeneous, high-affinity, primary, plaque-forming cell (PFC) response was further investigated. It was shown that the thymus acquires the capacity to facilitate this step in B cell differentiation between 3 and 4 weeks of age in C57BL/6 mice. This corresponds to the age at which te splenic B cell population of these mice naturally acquires the capacity to produce high-affinity PFC. The differentiation of the B cell population. It was further shown that regulates this step in the cells to facilitate the maturation of B cell population. It was further shown that the ability of thymus cells to facilitate the maturation of the B cell population decreases with age and is already markedly reduced in 30-week-old, long-lived, C57BL/6 mice. A qualitative or quantitative decrease in thymic function may thus be responsible for age-related changes in the function of the B cell population.
D000375:Aging; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002417:Cattle; D002454:Cell Differentiation; D004136:Dinitrobenzenes / Q000276:immunology; D007116:Immunization, Passive; D051379:Mice; D008810:Mice, Inbred C57BL; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013934:Thymectomy; D005719:gamma-Globulins / Q000276:immunology
D004136:Dinitrobenzenes; D005719:gamma-Globulins