HBs Ag and hepatocellular carcinoma associated with cirrhosis.--A retrospective study based on autopsy.
Histologic specimens of liver tissue from 33 consecutive cases of hepatocellular carcinoma (HCC) associated with cirrhosis, were stained with hematoxylin-eosin and with orcein for the presence of HBs Ag in the cytoplasm of cells. Such a study showed orcein-positive liver cells in 7 out of 33 (21.2%) cases of HCC associated with cirrhosis. The clinical course and laboratory examinations of the 33 patients were also reviewed and revealed a significant difference between the length of survival of orcein-positive patients and orcein-negative ones. Therefore, these results seem to support the hypothesis that HBs Ag may play a role not only in the development of HCC associated with cirrhosis, but also in a more rapid and severe course of neoplasia.
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000473:pathology*; D004396:Coloring Agents; D003593:Cytoplasm / Q000276:immunology*; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D006514:Hepatitis B Surface Antigens / Q000009:adverse effects / Q000302:isolation & purification*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010078:Oxazines; D013194:Staining and Labeling
D004396:Coloring Agents; D006514:Hepatitis B Surface Antigens; D010078:Oxazines; C002313:PAcein; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin