[Effect of a modified terrilytin on ampicillin pharmacokinetics in experimental peritonitis].
The effect of modified terrilytin, a new enzyme of the microbial origin on the pharmacokinetics of ampicillin in experimental peritonitis was studied on 16 pubertal rabbits. Peritonitis was caused by laparotomy and administration of a 15 per cent fecal suspension into the abdominal cavity. The drugs were injected intramuscularly: the enzyme in a dose of 5 PU/kg and the antibiotic in a dose of 10 mg/kg. The ampicillin levels in the blood and peritoneal exudate were determined with the agar-diffusion method. The specimens were collected 30 minutes, 1, 1.5 and 2 hours after administration of the drugs. The animals were divided into 2 groups: control (not treated with the enzyme) and experimental. An increase in the antibiotic levels in the blood and peritoneal exudate by 50--54 per cent was observed. The maximum increase was recorded 30 minutes after simultaneous administration of the drugs.
D000667:Ampicillin / Q000378:metabolism / Q000627:therapeutic use*; D000681:Amylases / Q000627:therapeutic use*; D000818:Animals; D004338:Drug Combinations / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D007700:Kinetics; D008297:Male; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
D004338:Drug Combinations; C009402:amylase, phosphates, proteases drug combinations; D000667:Ampicillin; D000681:Amylases; D010447:Peptide Hydrolases
Vliianie modifitsirovannogo terrilitina na farmakokinetiku ampitsillina pri éksperimental'nom peritonite.