title: [Propafenon and propranolol in the management of cardiac extrasystoles (author's transl)].
abstract: The anti-arrhythmic effectiveness of propafenon (3 x 150 mg daily) combined with propranolol (3 x 20 mg daily) was compared with that of each drug alone in 15 patients with stable ventricular and (or) supraventricular extrasystoles. The frequency of extrasystoles decreased on propafenon alone by 70% (P less than 0.05), without further decrease on additional propranolol administration. Propranolol alone on average caused no significant decrease infrequency (35%). The most important ECG changes with the combined treatment consisted of a definite increase in P-Q interval by an average of 25% (P less than 0.01) while with propafenon alone it was 13%, with propranolol alone 19% . Propafenon plus propranolol decreased heart rate by a mean of 17% (P less than 0.01). The additive effect of both substances can lead to an inhibition of atrioventricular conduction and of sinus node function.
mesh_terms: D000328:Adult; D000368:Aged; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011405:Propafenone; D011427:Propiophenones / Q000008:administration & dosage / Q000627:therapeutic use*; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D011427:Propiophenones; D011405:Propafenone; D011433:Propranolol
vernacular_title: Kombinierte Anwendung von Propafenon und Propranolol bei extrasystolischen Herzrhythmusstörungen.