title: Stimulation of activated rat T cells in vitro by Listeria monocytogenes antigens.
abstract: A soluble extract of Listeria monocytogenes bound firmly and in similar amounts to a variety of rat cells. Cells that bound this material differed in their capacity to stimulate the in vitro proliferation of lymphocytes obtained from the thoracic duct of Listeria-immune donors. The capacity of cells to serve as antigen-presenting cells in this system coincided or closely overlapped the expression on these cells of an Ia antigen-like structure. Three lines of evidence indicate that T cells respond to L. monocytogenes antigen: the responder cells are members of a nylon-wool nonadherent population that lacks readily detectable surface immunoglobulin; they express determinants recognized by the W3/25 monoclonal antibody (a surface marker of rat peripheral T cells); and they are stimulated optimally by L. monocytogenes antigen when the latter is displayed on cells that share a haplotype with the responder lymphocytes.
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial; D001402:B-Lymphocytes / Q000276:immunology; D001665:Binding Sites; D002455:Cell Division; D002469:Cell Separation; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D008089:Listeria monocytogenes / Q000276:immunology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology*
chemical_list: D000942:Antigens, Bacterial; D000939:Epitopes