Intracranial suppuration 1968-1982--a 15 year review.
The CT scanner and the recognition of anaerobic organisms has altered the investigation and management of intracranial suppuration. Improved treatment of acute and chronic middle ear infection has also occurred. A 15 year retrospective review was undertaken to assess the effects of these changes. The ears and sinuses were confirmed as the major source of intracranial suppuration (69%) although initial presentation to ENT surgeons was less common (14%). Ear complications occur in childhood and in the fifth and sixth decades; sinus complications predominantly in the second and third decades. The incidence of sinus infection appears to be rising. With the introduction on the CT scanner cerebral abscess mortality declined from 27.5% to 6.5% and subdural abscess mortality halved. The introduction of metronidazole contributed to a drop in mortality. The use of the CT scanner and more accurate antibacterial treatment, including metronidazole, gives hope for a more successful outcome than was previously possible.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000150:complications* / Q000000981:diagnostic imaging; D001922:Brain Abscess / Q000150:complications / Q000401:mortality; D001927:Brain Diseases / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D004427:Ear Diseases / Q000150:complications / Q000000981:diagnostic imaging; D013354:Empyema, Subdural / Q000150:complications / Q000401:mortality; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008581:Meningitis / Q000150:complications / Q000401:mortality; D008875:Middle Aged; D010254:Paranasal Sinus Diseases / Q000150:complications / Q000000981:diagnostic imaging; D013492:Suppuration / Q000209:etiology*; D014057:Tomography, X-Ray Computed