title: Effect of Epomediol on the ATPase and adenylate cyclase activities in plasmamembranes isolated from rat liver.
abstract: The effect of Epomediol (Clesidren (R)) on the membrane ATPase and Adenylate Cyclase activities has been investigated using highly purified rat liver plasmamembranes. The drug, even at micromolar concentration, showed a significant stimulatory effect on Ca++/Mg++- ATPase, Ca++- ATPase and Adenylate Cyclase activities. In particular the effect on Ca++- ATPase activity suggests that the drug under study may favourably modulate the calcium intracellular homeostasis.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D002756:Cholagogues and Choleretics; D008565:Membrane Proteins; D013729:Terpenes; D012969:Sodium Fluoride; D005934:Glucagon; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000262:Adenylyl Cyclases; D000252:Calcium-Transporting ATPases; C031365:epomediol