Biological variation in the immunological release of histamine from replicates of passively sensitized human lung and its relation to histamine content.
The histamine content of weighed replicates of chopped human lung was found to vary greatly. Replicates also varied considerably in the amount of histamine released after passive sensitization with IgE and challenge with antigen. The amount of immunological release of histamine was poorly related to tissue histamine content. Consequently, expression of release as percent of content did not lead to any decrease in the amount of variation between replicates.
D000485:Allergens; D006632:Histamine; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007112:Immunity, Maternally-Acquired; D008168:Lung / Q000276:immunology*
D000485:Allergens; D006632:Histamine