title: Bicuculline and neuronal activity in motor cortex.
abstract: We have studied the effects of bicuculline applied in microgram quantities to the precruciate gyrus (motor cortex) of cat upon visually evoked and spontaneous single-unit and slow-wave activity. The bicuculline produced an increase in both the visually evoked and the spontaneous unit activity. A surface negative component of the slow-wave response was markedly enhanced by the bicuculline. This component was associated with an intense suppression of spontaneous single-unit activity. Therefore, we have found that bicuculline has a convulsant effect upon single-unit activity as previously reported by others. However, we also found that bicuculline potentiates a process which appears associated with an enhancement of inhibition.
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002415:Cats; D005071:Evoked Potentials / Q000187:drug effects; D009044:Motor Cortex / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D011712:Pyramidal Tracts / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced; D013569:Synapses / Q000187:drug effects
chemical_list: D001640:Bicuculline