The axonal pathology in chronic IDPN intoxication.
Neurofilamentous axonal swellings occur in a number of degenerative and toxic disorders of the nervous system. In one of these, experimental intoxication with beta, beta'-iminodiproprionitrile (IDPN), accumulation of neurofilaments has been shown to result from a defect in slow axonal transport. The consequence of this functional abnormality is a series of changes in axonal morphology: Neurofilaments accumulate in the proximal axon; the proximal axon becomes swollen; the distal axon loses volume (axonal atrophy). These studies indicate that axonal atrophy occurs secondary to an impairment of slow axonal transport and suggest that a similar abnormality may underlie the pathological changes in certain other degenerative and toxic diseases of the nervous system.
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D001369:Axons / Q000187:drug effects* / Q000648:ultrastructure; D003599:Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D008297:Male; D009046:Motor Neurons / Q000187:drug effects / Q000648:ultrastructure; D009186:Myelin Sheath / Q000187:drug effects / Q000648:ultrastructure; D009570:Nitriles / Q000506:poisoning*; D051381:Rats; D013116:Spinal Cord / Q000033:anatomy & histology / Q000187:drug effects*; D013126:Spinal Nerve Roots / Q000033:anatomy & histology / Q000187:drug effects
D009570:Nitriles; C008110:3,3'-iminodipropionitrile