Hypothermia induced in mice by enzyme-mediated depletion of serotonin.
Injection of a purified serotonin (and tryptophan)-degrading enzyme into mice produced a pronounced hypothermia when the mice were maintained at 22 degrees C, but not at 30 degrees C. Brain levels of serotonin and tryptophan were strikingly depleted, but concentrations of norepinephrine and dopamine remained unchanged.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007035:Hypothermia / Q000139:chemically induced / Q000378:metabolism*; D007211:Indoles / Q000494:pharmacology; D051379:Mice; D006899:Mixed Function Oxygenases / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*; D013696:Temperature
D007211:Indoles; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D006899:Mixed Function Oxygenases; C021442:indolyl-3-alkane-alpha-hydroxylase