Oligostatins, new antibiotics with amylase inhibitory activity. I. Production, isolation and characterization.
Oligostatins C, D and E, three new antibiotics were found in the culture filtrate of Streptomyces myxogenes nov. sp. SF-1130. Their spectral and chemical properties suggested that oligostatins were basic oligosaccharide antibiotics. They exhibited not only antibacterial activity but also strong amylase inhibitory activity.
D000617:Aminoglycosides / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D000681:Amylases / Q000037:antagonists & inhibitors*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D013302:Streptomyces / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C017723:oligostatin C; C025238:oligostatin E; C013687:oligostatin D; D000681:Amylases