Substance P elicited grooming in the mouse: behavioral and pharmacological characteristics.
Substance P undercapeptide produces intense grooming after central injection. To characterize further this syndrome at behavioral and psychopharmacological level: (a) substance P elicited grooming was compared to spontaneously occurring grooming for their respective behavioral characteristics, and (b) a variety of centrally active substances were injected in an attempt to modify the normal occurrence of the grooming syndrome. Manipulations of opioid systems did not affect grooming, nor did a variety of other peptides. However, central injections of neurotensin significantly inhibited grooming. This interaction may represent a functional behavioral correlate of the established neuroanatomical interactions of the above substances.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology; D003864:Depression, Chemical; D004600:Eledoisin / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects*; D006728:Hormones / Q000494:pharmacology; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009496:Neurotensin / Q000494:pharmacology; D013373:Substance P / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D004723:Endorphins; D006728:Hormones; D013373:Substance P; D009270:Naloxone; D009496:Neurotensin; D004600:Eledoisin; D009020:Morphine; D009075:MSH Release-Inhibiting Hormone; D001839:Bombesin