[Determination of enzyme activity and beta 2-microglobulin concentration in the urine in chronic diffuse glomerulonephritis and hypertension].
Activity of alanine aminopeptidase (AAP), aryl sulphatase A (ASA) beta-glucoronidase (beta-GA) and the concentration of beta 2-microglobulin in urine was determined in 12 patients with chronic diffuse glomerulonephritis and in 16 patients with essential hypertension. The control group consisted of 6 practically healthy persons. The AAP activity in urine of patients with chronic glomerulonephritis was significantly higher than that in healthy subjects. Renal excretion of lysosomal enzymes (ASA, beta-GA) appeared to be less expressed; no significant differences as regard to their excretion were noted between the above mentioned groups. Concentrations of beta 2-microglobulin in urine of patients with chronic glomerulonephritis 6 times exceeded its concentration in healthy persons and in hypertensive patients, more than 3 times as much. Determination of the enzyme activity and beta 2-microglobulin concentration in urine may serve a test in differential diagnosis, for evaluation of the treatment efficiency of patients with chronic glomerulonephritis accompanied by arterial hypertension and those suffering from essential hypertension.
D000328:Adult; D000626:Aminopeptidases / Q000652:urine*; D001192:Arylsulfatases / Q000652:urine*; D001609:Beta-Globulins / Q000652:urine*; D018826:CD13 Antigens; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis*; D005966:Glucuronidase / Q000652:urine*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D013053:Spectrophotometry; D013429:Sulfatases / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine*
D001609:Beta-Globulins; D001613:beta 2-Microglobulin; D013429:Sulfatases; D001192:Arylsulfatases; D005966:Glucuronidase; D000626:Aminopeptidases; D018826:CD13 Antigens
Opredelenie aktivnosti fermentov i kontsentratsii beta 2-mikroglobulina v moche bol'nykh khronicheskim diffuznym glomerulonefritom i gipertonicheskoĭ bolezn'iu.