Effects of Ca2+ ionophore A23187 and Ca2+ deficiency on pancreatic phospholipids and amylase release in vitro.
The Ca2+ ionophore A23187 elicits a transient increase in pancreatic amylase release in vitro, and this is accompanied by a transient decrease in phosphatidyl inositol concentration. Effects of ionophore A23187 and carbachol on amylase release and phosphatidylinisitol breakdown are dependent on medium Ca2+. These results suggest that major secretagogue-induced, pancreatic phospholipid changes follow, rather than precede, changes in Ca2+ in the pancreas.
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000172:deficiency*; D066298:In Vitro Techniques; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000502:physiology; D010712:Phosphatidic Acids / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000900:Anti-Bacterial Agents; D010712:Phosphatidic Acids; D010716:Phosphatidylinositols; D010743:Phospholipids; D000001:Calcimycin; D000681:Amylases; D002118:Calcium