Axonal transport in rats rendered paraplegic following a single subarachnoid injection of either batrachotoxin or 6-aminonicotinamide into the spinal cord.
Batrachotoxin (BTX) or 6-aminonicotinamide (6-AN) when injected into the subarachnoidal space of the lumbar spinal cord block fast axonal transport of 3H-protein in motor nerves. Axonal transport recovers partially within one day after administering BTX while the effect of 6-AN lasts for more than 21 days. These observations are discussed in relation to the onset and recovery of membrane depolarization observed in the extensor muscle.
D015120:6-Aminonicotinamide / Q000008:administration & dosage / Q000506:poisoning*; D000818:Animals; D001370:Axonal Transport; D001496:Batrachotoxins / Q000008:administration & dosage / Q000506:poisoning*; D005260:Female; D008564:Membrane Potentials; D009046:Motor Neurons / Q000378:metabolism; D009475:Neurons, Afferent / Q000378:metabolism; D009536:Niacinamide / Q000031:analogs & derivatives*; D010264:Paraplegia / Q000139:chemically induced / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord; D013997:Time Factors
D001496:Batrachotoxins; D009536:Niacinamide; D015120:6-Aminonicotinamide