The development of a relative hyperthermia during continuous clonidine infusion in the rat.
In rats the continuous infusion of clonidine (10 micrograms kg-1 h-1) produces a relative hyperthermia of approximately 0.6 degree C during the light phases but not the dark phases of a 10 day infusion period. It appears that the relative hyperthermia results from a clonidine infusion-induced attenuation of the fall in body temperature which normally occurs at the onset of the light phases.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002940:Circadian Rhythm; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007263:Infusions, Parenteral; D051381:Rats; D011921:Rats, Inbred WKY
D003000:Clonidine