Immunofluorescence study of amyloid P-component patterns in human nephropathies.
The localization of amyloid P-component (AP) staining was studied by immunofluorescence in renal biopsies from 106 patients with various nephropathies and from 3 patients with normal kidneys. Linear staining was observed along the glomerular basement membranes (GBM) of normal kidneys. In amyloidosis, AP was always present in the glomeruli. In arteriolar walls, AP was present in numerous cases with varied intensity. No fixation was observed along tubular basement membranes. The possible modification of the permeability of GBM, related to a possible modification of the electrical charge of the filtration barrier, can be supposed.
D000682:Amyloid / Q000032:analysis*; D000686:Amyloidosis / Q000378:metabolism; D001485:Basement Membrane / Q000378:metabolism; D001706:Biopsy; D002463:Cell Membrane Permeability; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism; D000683:Serum Amyloid P-Component; D013194:Staining and Labeling
D000682:Amyloid; D000683:Serum Amyloid P-Component