Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation.
The anti-platelet activity of beta-2-microglobulin (beta 2m) specific autoantibodies isolated from sera of patients with autoimmune diseases was tested in direct and ADP-induced aggregation assays. It was established that human anti-beta 2m autoantibodies and heterologous rabbit anti-beta 2m antibodies evoke a dose-dependent aggregation of human platelets. Anti-beta 2m autoantibodies also impaired ADP-induced platelet aggregation. Antibodies with anti-beta 2m activity could be desorbed from the platelets and lymphocytes of a patients with systemic lupus erythematosus who was not thrombocytopenic. The possibility that such autoantibodies may alter platelet function is considered.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies / Q000502:physiology*; D001327:Autoimmune Diseases / Q000276:immunology*; D001609:Beta-Globulins / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D001613:beta 2-Microglobulin / Q000276:immunology*
D001323:Autoantibodies; D001609:Beta-Globulins; D007074:Immunoglobulin G; D001613:beta 2-Microglobulin; D000244:Adenosine Diphosphate