Two allelic forms of mouse beta 2-microglobulin.
Two allelic forms of mouse beta 2-microglobulin (beta 2m), the small polypeptide chain of H-2 histocompatibility antigens, have been identified. The two forms can be distinguished by NaDodSO4/polyacrylamide gel electrophoresis. All inbred mouse strains express a single beta 2m isotype. Mice heterozygous for beta 2m synthesize both forms, showing codominant expression of beta 2m alleles. In mice heterozygous for both H-2 and beta 3m, individual H-2 histocompatibility antigens associate with both beta 2m forms. Preliminary structural studies indicate differences in peptide composition between the two forms.
D000483:Alleles; D000818:Animals; D001609:Beta-Globulins / Q000235:genetics*; D006579:Heterozygote; D008285:Major Histocompatibility Complex; D051379:Mice; D010446:Peptide Fragments / Q000032:analysis; D010641:Phenotype; D011110:Polymorphism, Genetic; D013154:Spleen / Q000276:immunology; D014357:Trypsin; D001613:beta 2-Microglobulin / Q000235:genetics*
D001609:Beta-Globulins; D010446:Peptide Fragments; D001613:beta 2-Microglobulin; D014357:Trypsin