Hybrid (combinatorial) Ia specificities: gene complementations to generate Ia.22.
Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (E alpha) encoded by the I-E subregion. Ia.22 can be generated by the complementation of Ab, Ak, As, Ar, with Ed, Ek, Ep, Er, Ew3, Eu, Ev but Eb, Ef, Eq, and Es. With the exception of H-2p which does not complement with As to generate Ia.22, all Ia. 7-positive (I-E) haplotypes can provide the permissive E alpha allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.
D000818:Animals; D011232:Chemical Precipitation; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D005816:Genetic Complementation Test; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006824:Hybridization, Genetic; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA
D000939:Epitopes; D000949:Histocompatibility Antigens Class II