T suppressor cells: role in dengue hemorrhagic fever and dengue shock syndrome.
The hypothesis presented envisages dengue virus infection in a host with preexisting parasitic infection. The dual infections may produce alterations in the immunoregulatory system that would lead to depletion of T suppressor cells. The resultant augmented production of IgG and IgE may be responsible for type III and type I hypersensitivity reactions, respectively.
D000936:Antigen-Antibody Complex; D003165:Complement System Proteins / Q000276:immunology; D003715:Dengue / Q000276:immunology*; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D010272:Parasitic Diseases / Q000276:immunology; D012769:Shock; D013601:T-Lymphocytes / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007073:Immunoglobulin E; D003165:Complement System Proteins