Comparison of acute cardiovascular effects and oxygen-supply following haemodilution with dextran, stroma-free haemoglobin solution and fluorocarbon suspension.
Changes in haemodynamics and myocardial oxygen-supply were investigated in anaesthetised dogs, when the haematocrit was reduced to 18 to 22% by isovalaemic haemodilution with 8% stroma-free haemoglobin solution, 20% Fluosol-DA and 6% dextran 70. Comparable haemodilution and comparable reduction in whole-blood viscosity was not followed by similar changes in cardiac output: dextran- and Fluosol-diluted dogs showed significantly elevated cardiac output, while haemoglobin-diluted dogs failed to do so. As a result, systemic O2-transport was better maintained with dextran and Fluosol. Myocardial blood flow, estimated by 15 micrometers microspheres, increased in all three haemodiluted groups, but oxygen-supply was not similar. The haemoglobin-diluted dogs showed inadequate O2-supply suggested by a fall of coronary sinus pO2; dextran-diluted dogs exhibited adequate O2-supply suggested by maintained coronary sinus pO2, while the Fluosol-diluted group enjoyed excessive O2-supply, indicated by a markedly elevated pO2 in coronary sinus blood. The observations suggest that similar degrees of haemodilution may not be followed by comparable changes in haemodynamics and O2-supply, depending on O2-unloading characteristics.
D000818:Animals; D003326:Coronary Circulation; D003911:Dextrans / Q000494:pharmacology; D004285:Dogs; D005466:Fluorocarbons / Q000494:pharmacology; D006438:Hemodilution; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000097:blood*
D003911:Dextrans; D005466:Fluorocarbons; D006454:Hemoglobins; D010100:Oxygen