Dopamine (DA) and serotonin metabolic levels in the cerebrospinal fluid (CSF) in Alzheimer's presenile dementia under basic conditions and after stimulation with cerebral cortex phospholipids (BC-PL).
HVA and 5-HIAA levels in CSF were investigated in ten patients with presenile Alzheimer's dementia. As reported by others, CSF levels of dopamine and serotonin metabolism are lower in patients with presenile dementia than in normal controls of the same age. After lumbar puncture, the patients were treated with cerebral cortex phospholipids (200 mg i.v. daily). This produced a significant increase in CSF levels of HVA and 5-HIAA, as well as a reduction of serum PL. The data are interpreted as proving an active pharmacological action of cerebral cortex phospholipids on the various processes of the neurotransmitter substances in demential syndromes.
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D002540:Cerebral Cortex / Q000187:drug effects*; D003704:Dementia / Q000134:cerebrospinal fluid*; D004298:Dopamine / Q000134:cerebrospinal fluid*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008875:Middle Aged; D010743:Phospholipids / Q000494:pharmacology*; D012701:Serotonin / Q000134:cerebrospinal fluid*
D010743:Phospholipids; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid