[Biological markers for tumours of the testis. Their use in diagnosis, prognosis and follow-up in 200 cases (author's transl)].
Repeated measurements of serum chrionic gonadotrophic hormone (CGH), of its beta sub-unit (beta CGH) and of alpha-foetoprotein (aFP) were performed in 200 patients with germinal tumours of the testis. CGH levels were found to be high in 43,5% of patients, particularly those with choriocarcinoma (a rare tumour) or with embryonal carcinoma with syncytiotrophoblastic (ST) cells. They were also high in 24% of patients with histologically pure seminoma, which throws doubts on the homogeneity of this group of tumours and raises problems concerning their treatment in patients with high CGH. aFP levels were increased in 38% of all patients, particularly those with ST cell embryonal carcinoma (62%) or with malignant teratoma (56%). These biochemical markers may point to a histological diagnosis. They also have prognostic value and are essential for monitoring during treatment. Pre-operative assays are to particular interest and should be performed in every case.
D000328:Adult; D002822:Choriocarcinoma / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood*; D004407:Dysgerminoma / Q000097:blood; D006801:Humans; D008297:Male; D011300:Preoperative Care; D011379:Prognosis; D013724:Teratoma / Q000097:blood; D013736:Testicular Neoplasms / Q000097:blood* / Q000473:pathology / Q000628:therapy; D000509:alpha-Fetoproteins / Q000032:analysis*
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins
Marqueurs biologiques des tumeurs testiculaires. Utilisation pour le diagnostic, le pronostic et la surveillance: 200 observations.