Effects of somatostatin, glucagon and insulin on glycogen synthesis in isolated rat hepatocytes.
The effects of somatostatin on basal and hormone-mediated rates of glycogenesis were studied in isolated rat hepatocytes. Somatostatin (1.5 X 10(-11) - 1.5 X 10(-8) M) had no effect on glycogen synthesis in the presence of 30 mM glucose and did not overcome a glucagon (1.5 X 10(-10) M)-induced inhibition of glycogenesis.
D000818:Animals; D005934:Glucagon / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*
D007328:Insulin; D008112:Liver Glycogen; D013004:Somatostatin; D005934:Glucagon