Synergistic effect of cis-dichlorodiammineplatinum and 5-aza-2'-deoxycytidine on mouse leukemic cells in vivo and in vitro.
cis-Dichlorodiammineplatinum and 5-aza-2'-deoxycytidine display a considerable synergistic effect in L1210 and La mouse leukemia in vivo; the combination of both drugs is also clearly synergistic in vitro as evidenced by the effects on cell growth and cell survival in soft-agar medium. In exponential but not in stationary growth of L1210 cells, the drugs interfere with DNA and RNA synthesis.
D000818:Animals; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D000077209:Decitabine; D004357:Drug Synergism; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012334:RNA, Neoplasm / Q000096:biosynthesis
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D000077209:Decitabine; D007930:Leucine; D001374:Azacitidine; D002945:Cisplatin