Factors involved in the control of RNA synthesis during regeneration of the optic nerve in the frog.
The incorporation of tritiated uridine into retinal ganglion cells was studied following intra- and extracranial section of the optic nerve in the frog. It was found that incorporation increased to above control levels by two days following extracranial section of the optic nerve and by two weeks following intracranial section and was maintained at an elevated level until the regenerating optic nerve reached the diencephalon, at which point the rate of incorporation fell back to control levels. It is suggested that the signal for turning off increased uridine incorporation lies in the diencephalon, and that functional reconnection is not the signal.
D000818:Animals; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D011894:Rana pipiens; D012160:Retina / Q000378:metabolism; D013477:Superior Colliculi / Q000378:metabolism; D014795:Visual Pathways / Q000378:metabolism
D012313:RNA