Bilateral ablation of the corticostriatal projection: behavioral, biochemical and electrophysiological correlates.
Striatal neuronal responses to dexamphetamine, 2.5 mg/kg i.p., were examined in normal and bilateral cortically ablated freely moving rats using multiunit recording. Striatal glutamate levels, D1 and D2 receptor binding, and haloperidal catalepsy were examined in both sham-operated and ablated animals. Bilateral ablation of the cortex, while not affecting dexamphetamine-induced behavioral activation, changed the striatal neuronal response from predominantly excitation to inhibition. Striatal glutamate levels were reduced 22% in ablated animals; and dopamine D-2 receptor binding sites were similarly decreased by 20%. In bilaterally ablated animals, haloperidol-induced catalepsy was greatly reduced.
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004594:Electrophysiology; D005971:Glutamates / Q000032:analysis; D018698:Glutamic Acid; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000032:analysis; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2
D005971:Glutamates; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D018698:Glutamic Acid; D006220:Haloperidol; D003913:Dextroamphetamine