title: [Diagnostic significance of pancreatic serum-enzyme patterns after stimulation with secretin in chronic pancreatitis (author's transl)].
abstract: The pancreatic serum evocation test with secretin has regained importance now that it is possible to determine immunoreactive trypsin and pancreatic isoamylase. After secretin stimulation there was a significant abnormal increase in serum trypsin (p less than 0.01) in 34 patients with proven chronic pancreatitis associated with mild to moderate dysfunction (groups I-II), no rise if there was marked insufficiency (group III). Patients with steatorrhoea and obstruction in the region of the head of the pancreas formed a special group because, contrary to other patients in groups III, they had marked serum enzyme rise after secretin. In 24 control subjects with a normal pancreas there was no significant change in basal pancreatic serum enzyme levels with secretin stimulation. Trypsin and amylase reaction patterns differed during secretin stimulation, with a rise in the amylase occurring at the expense of pancreas isoamylase.
mesh_terms: D000328:Adult; D000368:Aged; D000681:Amylases / Q000097:blood; D010188:Exocrine Pancreatic Insufficiency / Q000201:enzymology; D005260:Female; D006026:Glycoside Hydrolases / Q000097:blood*; D006801:Humans; D007517:Isoamylase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000201:enzymology*; D012633:Secretin; D014357:Trypsin / Q000097:blood*
chemical_list: D012633:Secretin; D000681:Amylases; D006026:Glycoside Hydrolases; D007517:Isoamylase; D014357:Trypsin
vernacular_title: Diagnostische Bedeutund des pankreatischen Serumenzymmusters nach Stimulation mit Sekretin bei chronischer Pankreatitis.