Pancreatic islet-acinar cell interaction: amylase messenger RNA levels ar determined by insulin.
Pancreatic amylase messenger RNA progressively decreases in rats rendered diabetic with streptozotocin. Insulin reverses this effect, inducing a selective decrease in amylase messenger RNA in the pancreas. Parotid amylase messenger RNA is not significantly affected by either diabetes or insulin.
D000681:Amylases / Q000235:genetics*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D007328:Insulin / Q000494:pharmacology / Q000502:physiology*; D007515:Islets of Langerhans / Q000502:physiology*; D007700:Kinetics; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000235:genetics; D014176:Protein Biosynthesis / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects; D014362:Trypsinogen / Q000235:genetics
D007328:Insulin; D012333:RNA, Messenger; D014362:Trypsinogen; D000681:Amylases; D010196:Pancreatic Elastase