title: Comparison of the antimuscarinic activity of mianserin and amitriptyline in the cat superior cervical ganglion.
abstract: The antimuscarinic activity of mianserin and amitriptyline was investigated in the cat superior cervical ganglion using McN-A-343 as a muscarinic agonist. Mianserin was found to have a similar order of potency to amitriptyline in this preparation, in contrast to the marked difference in their antimuscarinic activities on non-neuronal muscarinic receptors. These findings suggest that the action of mianserin on neuronal muscarinic receptors is more important than that predicted from studies on non-neuronal receptors and may be related to its anti-depressant activity.
mesh_terms: D008455:(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride / Q000037:antagonists & inhibitors; D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003984:Dibenzazepines / Q000494:pharmacology*; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D009541:Nictitating Membrane / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects
chemical_list: D003984:Dibenzazepines; D010276:Parasympatholytics; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011985:Receptors, Serotonin; D000639:Amitriptyline; D008803:Mianserin; D004246:Dimethylphenylpiperazinium Iodide; D008455:(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride