Different levels of changes induced by the insecticide lindane in cultured C-6 glioma cells.
The effects of lindane on alpha-aminoisobutyric acid and uridine uptake were studied in the rat line C-6 of glial origin. Different levels of modifications could be distinguished by use of 2 modes of investigation. One study, carried out within minutes of contact with lindane, has shown that the inhibition of alpha-aminoisobutyric acid and uridine uptake was rapid and immediately reversible. The other study, carried out after several hours of treatment followed by a 15-min triple washing, has allowed to attribute the non-reversible decrease in uridine uptake induced by a 20-h treatment to an inhibition of protein synthesis, and the increase in alpha-aminoisobutyric acid uptake to the derepression of synthesis of transport proteins.
D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis; D002478:Cells, Cultured; D005910:Glioma / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000378:metabolism; D051381:Rats; D014529:Uridine / Q000378:metabolism
D000621:Aminoisobutyric Acids; D002352:Carrier Proteins; D001556:Hexachlorocyclohexane; D014529:Uridine