[Preoperative chemotherapy of squamous cell carcinoma of the head and neck with V-T-M schedule (author's transl)].
13 patients with far advanced squamous cell carcinoma of the head and neck were treated with a low dose combination chemotherapy of Vincristine, Bleomycin and Methrotrexate during 7--8 weeks prior to surgery or radio-therapy. V-B-M was given as an out- patient regimen. 9 patients were treated the first time ever, 4 patients suffered of tumor-recurrence. 5 patients i.e. 38% achieved complete remission of all measurable disease, a total of 9 patients i.e. 69% achieved a partial remission of more than 50%. Prior treatment or localisation of tumor did not influence the results. Competent application warranted, toxicity was mild. The significance of pre-operatively achieved complete remission is discussed. Short-term follow up does not yet permit any statement upon survival.
D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D001761:Bleomycin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D011379:Prognosis; D012075:Remission, Spontaneous; D014750:Vincristine / Q000627:therapeutic use*
D001761:Bleomycin; D014750:Vincristine; D008727:Methotrexate
Präoperativ- chemotherapeutische Behandlung bei Plattenepithelkarzinomen im Kopf-Hals-Bereich mit dem V-B-M-Schema.