Effects of beta-adrenoceptor blockade on prostacyclin mediated renin release in sheep.
The effect of prostacyclin (PGI2) infusion on plasma renin concentration (PRC) was examined before and after propranolol treatment in sheep. Increasing doses of prostacyclin (0.05, 0.1 or 0.3 micrograms/kg per min) produced dose dependent increases in PRC. There was a significantly lower PRC response after propranolol at 0.3 micrograms/kg per min only.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012083:Renin / Q000097:blood* / Q000378:metabolism; D012756:Sheep; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D011464:Epoprostenol; D012083:Renin; D007545:Isoproterenol