Further evidence for the neuroleptic-like activity of gamma-endorphin.
gamma-Endorphin inhibits the amphetamine-induced stereotypy in rats with an approximate ED50 of 0.3 mg/kg. SC. The anti-amphetamine effect of gamma-endorphin can be antagonized to a certain extent by both the dopamine receptor stimulant 2-bromo-ergocryptine and the opiate receptor antagonist naloxone.
D000818:Animals; D014150:Antipsychotic Agents; D001971:Bromocriptine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D018823:gamma-Endorphin
D014150:Antipsychotic Agents; D004723:Endorphins; D009270:Naloxone; D001971:Bromocriptine; D018823:gamma-Endorphin; D009020:Morphine; D006220:Haloperidol; D003913:Dextroamphetamine