Normal subunit cleavage of alpha-2-macroglobulin in cystic fibrosis.
Alpha-2-macroglobulin (alpha 2-M) has been purified from the plasma of patients with cystic fibrosis and normal controls, and the proteolytic subunit cleavage on reaction with trypsin has been compared. As no differences were observed between the two groups, a primary genetic defect affecting alpha 2M subunit cleavage in cystic fibrosis is unlikely.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007223:Infant; D008970:Molecular Weight; D009154:Mutation; D011487:Protein Conformation; D014357:Trypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000235:genetics / Q000378:metabolism*
D000511:alpha-Macroglobulins; D014357:Trypsin