title: Placenta-associated plasma protein-A (PAPP-A, SP4) in trophoblastic tumours.
abstract: The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas. PAPP-A was found in the syncytiotrophoblast of all hydatidiform moles, in 5 of the 6 invasive moles and in 6 of the 7 choriocarcinomata. No clinical difference was observed between PAPP-A positive and negative cases of invasive disease.
mesh_terms: D002822:Choriocarcinoma / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis*; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D014328:Trophoblastic Neoplasms / Q000032:analysis*; D014594:Uterine Neoplasms / Q000032:analysis*
chemical_list: D011257:Pregnancy Proteins; D011266:Pregnancy-Associated Plasma Protein-A