[The influence of low molecular dextrans on the survival of fibrinogen and platelets in rabbits (author's transl)].
Dextrans have various biological effects dependent on their molecular size. The thromboprophylactic effect of low molecular dextrans (LMDx) is due to a multifactorial mechanism leading to some coagulative changes without bleeding risk. Whereas some properties of platelets and plasma fibrinogen are modified by LMDx, there is no information about its influence on the survival times and catabolic rates which have been investigated in this study using 125I-fibrinogen and 75Se-selenomethionine for the in vivolabelling of the platelets. Both dextran 40 and 60 were found to cause a significant reduction of plasma fibrinogen level, platelet counts, and haematocrit during the first 3 hours after dextran infusion. the changes in TEG (prolongation of r+k-time, decrease in thrombus elasticity) were normalised 12 hours after the end of the dextran application. The survival times and catabolic rates of 125 I-fibrinogen and in vivo-labelled platelets, however, were not changed by dextran 40 or 60. But both LMDx seemed to accelerate the incorporation of the radioactive methionine into the platelets. this phenomenon might be explained by the physico-chemical properties of LMDx which guarantee the antihrombotic effects too.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism*; D006400:Hematocrit; D008715:Methionine / Q000378:metabolism; D011817:Rabbits
D003911:Dextrans; D005340:Fibrinogen; D008715:Methionine
Uberlebenszeiten von fibrinogen und Thrombozyten nach Dextran-Infusion beim Kaninchen.