title: [Metabolism of guanine in the adenohypophysis of the male rat during growth and after castration].
abstract: During incubation of the male Rat pituitary, guanine is metabolized according to two ways: the first one leads to the guanylic nucleotides subsequently incorporated into the RNA; the second one produces xanthine and uric acid. If guanosine is used as a precursor, the nucleoside is converted into guanine before utilisation thus suggesting a low level of guanosine kinase activity. The production of xanthine is higher in adult animals than in immature ones and it is increased following gonadectomy. It follows that the pituitary guanine deaminase could be considered as an enzyme regulated by sexual hormones.
mesh_terms: D000375:Aging; D000818:Animals; D002369:Castration; D006147:Guanine / Q000378:metabolism*; D006150:Guanine Nucleotides / Q000378:metabolism; D007700:Kinetics; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D051381:Rats; D012741:Sexual Maturation
chemical_list: D006150:Guanine Nucleotides; D006147:Guanine; D012313:RNA
vernacular_title: Métabolisme de la guanine dans l'adénohypophyse du rat mâle au cours de la croissance et après castration.