Value of the determination of "true' free thyroxine in screening the newborn with possible congenital TBG-deficiency for congenital hypothyroidism.
The results of investigation on a family after a screening programme for congenital hypothyroidism are presented. The newborn child and her father appeared to have a congenital thyroxine binding globulin deficiency. Problem regarding standard thyroid hormone tests are discussed. It was observed that the free T4 index as well as a commercial free T4 determination introduced earlier can give misleading results. The first experience with another more promising free T4 determination is also presented.
D000328:Adult; D000510:Alpha-Globulins / Q000172:deficiency*; D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis*; D008297:Male; D011933:Reagent Kits, Diagnostic; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood*; D013975:Thyroxine-Binding Proteins / Q000172:deficiency*
D000510:Alpha-Globulins; D011933:Reagent Kits, Diagnostic; D013975:Thyroxine-Binding Proteins; D013972:Thyrotropin; D013974:Thyroxine