Suicide transport: destruction of neurons by retrograde transport of ricin, abrin, and modeccin.
Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.
D000036:Abrin; D000818:Animals; D001370:Axonal Transport; D037102:Lectins; D051379:Mice; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D037121:Plant Lectins; D010940:Plant Proteins; D012183:Retrograde Degeneration; D054790:Ribosome Inactivating Proteins, Type 2; D012276:Ricin
D037102:Lectins; D037121:Plant Lectins; D010940:Plant Proteins; D054790:Ribosome Inactivating Proteins, Type 2; D000036:Abrin; C016004:modeccin; D012276:Ricin