[RNA accumulation in the soma of neurons as an index of their functional deafferentation].
Ultraviolet and visible cytospectrophotometry showed the longterm functional deafferentation due to a visual deprivation or a forced hypokinesia, to lead to a marked RNA accumulation in the visual neurons of the cerebral cortex or in the motoneurons of the spinal cord. Similar though somewhat less obvious RNA accumulation occurred after an intensive stimulation of these neurons, whereas a combination of the deafferentation and stimulation attenuated and in some cases eliminated the deafferentation-induced RNA accumulation. The data obtained suggest that the RNA accumulation in neurons means a decreased rather than increased sensory input. In this case, mechanism of this RNA accumulation consists in a decrease of the RNA utilization within such neurons.
D000818:Animals; D001274:Atmospheric Pressure; D001931:Brain Mapping; D006651:Histocytochemistry; D000860:Hypoxia / Q000378:metabolism; D008297:Male; D009046:Motor Neurons / Q000378:metabolism*; D009068:Movement; D012313:RNA / Q000378:metabolism*; D051381:Rats; D012683:Sensory Deprivation; D013116:Spinal Cord / Q000378:metabolism*; D014785:Vision, Ocular / Q000502:physiology; D014793:Visual Cortex / Q000378:metabolism*
D012313:RNA
Nakoplenie RNK v tele neĭronov kak pokazatel' ikh funktsional'noĭ deafferentatsii.