Antigenic differences between a primary hamster lymphosarcoma and its liver metastases.
An antiserum was raised in rabbits against a primary metastasizing lymphosarcoma (ML) of the hamster. This was made tumor-specific by absorption with normal hamster tissue extracts. Immunoglobulin-G was prepared and tested for its cytotoxicity towards cells derived from the primary tumor and its liver metastases. The ML-specific IgG was found to be 2--5 times more cytotoxic for cells derived from the primary tumor compared to cells obtained from liver metastases.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D006224:Cricetinae; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology / Q000556:secondary*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000276:immunology
D000951:Antigens, Neoplasm; D000939:Epitopes; D007074:Immunoglobulin G