[Clinical observations on the rheological and hemodynamic effects of some drugs acting on the microcirculation].
A clinical research was carried out on the rheological and haemodynamic effects of various drugs commonly employed in the treatment of certain disturbances of the microcirculation. In addition to low molecular weight dextrane, a comparison was also made of three other substances theoretically capable of interfering with the fundamental relationship between viscosity, volume and haemodynamics. Assessment of the clinical signs was made both via evaluation of the peripheral haemodynamics during rest and during post-ischaemic hyperaemia and through determination of changes in blood viscosity by means of an original capillary viscosimeter. Some conclusions of a certain speculative and practical interest are drawn from the research as a whole.
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002908:Chronic Disease; D003911:Dextrans / Q000494:pharmacology / Q000627:therapeutic use*; D005780:Gelatin / Q000494:pharmacology / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged
D003911:Dextrans; D005780:Gelatin; D006493:Heparin
Osservazioni cliniche sull'azione reologica ed emodinamica di taluni farmaci attivi sul microcircolo.