Sleep-waking cycle in microencephalic rats induced by prenatal methylazoxymethanol application.
Sleep-wakefulness cycle of adult microencephalic rats due to prenatal administration of methylazoxymethanol (MAM) acetate at the dose of 20 mg/kg on the 15th day of gestation showed no difference from the normal control group, whereas at the dose of 25 mg/kg, %PS and PS/TS decreased significantly. MAM-induced microencephalic rats revealed a significant increase of spindle bursts during PS, suggesting that their PS is less deep than that of the controls.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002531:Cerebellum / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000494:pharmacology*; D008831:Microcephaly / Q000139:chemically induced*; D051381:Rats; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000187:drug effects*
D001391:Azo Compounds; D008746:Methylazoxymethanol Acetate