Synthesis of perhydro-1,2,5-dithiazepine derivatives of potential pharmacological activity.
New derivatives of perhydro-1,2,5-dithiazepine, 1-18, were synthesized. Compounds 1 and 16 showed spasmolytic and antihistaminic activity stronger than their analogs containing perhydro-1,4-thiazepine system.
D000818:Animals; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists; D066298:In Vitro Techniques; D010276:Parasympatholytics; D013329:Structure-Activity Relationship; D013841:Thiazepines / Q000138:chemical synthesis*
D006634:Histamine H1 Antagonists; D010276:Parasympatholytics; D013841:Thiazepines