title: The virus-activated suppressor cell hypothesis in experimental and human rheumatic diseases.
abstract: I suggest that many of the features of the autoimmune diseases may be explained by an alteration in the immunoregulatory balance of various T lymphocyte populations by virus-activated suppressor cells. The evidence for this hypothesis is presented and evaluated in adjuvant disease in rats, NZB/W disease in mice, and in human autoimmune diseases.
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000209:etiology; D001327:Autoimmune Diseases / Q000209:etiology; D005620:Freund's Adjuvant / Q000494:pharmacology; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB; D009161:Mycobacterium / Q000276:immunology; D011134:Polysaccharides / Q000494:pharmacology; D011714:Pyrans / Q000494:pharmacology; D051381:Rats; D012190:Retroviridae / Q000276:immunology; D012216:Rheumatic Diseases / Q000276:immunology*; D012254:Ribavirin / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013994:Tilorone / Q000494:pharmacology; D014780:Viruses / Q000276:immunology*
chemical_list: D011134:Polysaccharides; D011714:Pyrans; C100186:statolon; D012254:Ribavirin; D005620:Freund's Adjuvant; D007372:Interferons; D013994:Tilorone