title: Implications of the reorganization of the cell genome for aging or immortalization of dividing cells in vitro.
abstract: Cellular aging or immortalization depends on random reorganization of the cell genome and is determined by chance, intrinsic properties of the cell and environmental factors. The probability of creating a new genetic progressively autonomous program is higher for some cells than for others and is increased by external events that introduce de novo information.
mesh_terms: D000818:Animals; D002417:Cattle; D002470:Cell Survival; D002642:Chick Embryo; D002875:Chromosomes / Q000648:ultrastructure; D006224:Cricetinae; D004261:DNA Replication; D005347:Fibroblasts / Q000166:cytology; D005796:Genes; D006801:Humans; D051379:Mice; D008938:Mitosis; D012313:RNA / Q000096:biosynthesis; D011817:Rabbits; D051381:Rats
chemical_list: D012313:RNA