Interferon and spontaneous cytotoxicity in man. IV. Evidence for interferon as the factor in human interferon preparations causing enhancement of spontaneous cytotoxicity.
Human interferon preparations of varying degrees of purity derived from leukocytes, fibroblasts and lymphoblastoid cells all enhanced the spontaneous cytotoxicity of human peripheral lymphocytes, while mouse interferon and human mock interferon preparations did not exert this effect. Fibroblast interferon purified to homogeneity with regard to molecular weight also increased the spontaneous cytotoxicity of lymphocytes. These results indicate that the factor in interferon preparations responsible for the enhancement of spontaneous cytotoxicity is interferon itself.
D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D007372:Interferons / Q000302:isolation & purification / Q000494:pharmacology*; D007962:Leukocytes / Q000502:physiology; D008214:Lymphocytes / Q000276:immunology*
D007372:Interferons