Plasma luteinizing hormone in ovariectomized rats following pharmacologic manipulation of endogenous brain serotonin.
Ovariectomized rats were treated with pharmacologic agents to manipulate endogenous brain serotonin (5-HT). Neither the magnitude nor the timing of luteinizing hormone (LH) pulses in plasma were affected by drug-induced decreases in 5-HT. Acute increases in extraneuronal 5-HT resulting from fluoxetine administration to inhibit 5-HT uptake into neurons, decreased the magnitude of LH pulses, but did not affect the interval between successive LH pulses.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002369:Castration; D005260:Female; D010134:Fenclonine / Q000031:analogs & derivatives / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D010133:p-Chloroamphetamine / Q000494:pharmacology
D005473:Fluoxetine; C020261:4-chlorophenylalanine methyl ester; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010133:p-Chloroamphetamine; D007986:Luteinizing Hormone; D010134:Fenclonine