Age- and sex-related variations of serum thyroxine binding globulin.
Measurements of serum thyroxine binding globulin (TBG) by a ligand partitioning sandwich assay were performed in 173 healthy subjects between three months and 92 yr of age. Significant sex-related differences were observed in subjects aged 21 to 50 yr. In males, serum TBG declined progressively reaching a nadir in the fourth decade and then increased with advancing age. In contrast, no significant age-related variation was observed in females.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000510:Alpha-Globulins / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013975:Thyroxine-Binding Proteins / Q000378:metabolism*
D000510:Alpha-Globulins; D013975:Thyroxine-Binding Proteins