title: [Radical operation and recurrence prevention with azulfidine in Crohn disease: a prospective multicenter study--initial results].
abstract: The influence of radical versus more restricted operation and Azulfidine prophylaxis was studied in a controlled, partially randomized double blind multicenter trial (16 centres) in 177 patients over 3 years. Early relapse occurred more frequently in the radically operated group (49 vs. 31%) and less frequently under Azulfidine prophylaxis (34 vs. 46%). The radical operation had no advantage over the more restricted procedure and should be abandoned in Crohn's disease.
mesh_terms: D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003424:Crohn Disease / Q000601:surgery*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control; D012008:Recurrence; D012460:Sulfasalazine / Q000627:therapeutic use*
chemical_list: D012460:Sulfasalazine
vernacular_title: Operative Radikalität und Rezidivprophylaxe mit Azulfidine bei M. Crohn: Eine prospektive multizentrische Studie--Erste Ergebnisse.