[Nonuniform effect of cataleptogenic and atypical neuroleptics on the turning reactions induced by stimulation of the putamen and caudate nucleus in cats].
The cataleptogenic neuroleptics haloperidol and metoclopramide reduce contralateral head turning in cats upon stimulation of the putamen and enhance these reactions from the caudate nucleus. At the same time administration of the drugs interferes with the formation of the circling. The atypical neuroleptics clozapine and sulpiride decrease unidirectionally the thresholds of contralateral head turning from both parts of the neostriatum, facilitating the coordinated locomotion. It is assumed that discrepancy in the activity of the putamen and caudate nucleus may be one of the causes neuroleptic-induced extrapyramidal side effects in view of different dopaminergic organization of the structures under consideration.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced*; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects*; D003024:Clozapine / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006257:Head; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D009068:Movement / Q000187:drug effects; D011699:Putamen / Q000187:drug effects*; D012399:Rotation; D013469:Sulpiride / Q000494:pharmacology
D014150:Antipsychotic Agents; D013469:Sulpiride; D003024:Clozapine; D006220:Haloperidol; D008787:Metoclopramide
Neodinakovoe vliianie kataleptogennykh i atipichnykh neĭroleptikov na vrashchatel'nye reaktsii, vyzvannye razdrazheniem skorlupy i khostatogo iadra u koshek.