The effects of the specific uptake inhibitor Lu 10-171 (citalopram) upon brain indoleamine stores in the maturing mouse.
1. The specific 5-HT uptake inhibitor Lu 10-171 (Citalopram) was used to test uptake inhibition and reduced turnover in maturing mouse brain. 2. All ages showed 5-hydroxyindole acetic acid (5-HIAA) elevation indicative of inhibition and reduced turnover. Enzymatic blockade in conjunction with Lu 10-171 supported the evidence for reduced turnover. 3. The significance of early serotonergic maturation is discussed.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000375:Aging; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D015283:Citalopram; D006834:Hydrazines / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051379:Mice; D011437:Propylamines / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D006834:Hydrazines; D011437:Propylamines; D012702:Serotonin Antagonists; D015283:Citalopram; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C020173:NSD 1034; D006916:5-Hydroxytryptophan