Phenoxybenzamine reduces bladder outlet obstruction in benign prostatic hyperplasia. A urodynamic investigation.
Nine patients with bladder outlet obstruction attributable to benign prostatic hyperplasia were treated with 15 mg of phenoxybenzamine daily. Spontaneous urinary flow, water cystometry, simultaneous pressure-flow-EMG, and the urethral closure pressure profile were measured before and at the end of 4 weeks of treatment with phenoxybenzamine. A significant reduction in residual urine volume and a significant increase in the first sensation and bladder capacity were found. All voiding pressure parameters were significantly reduced and flow rates significantly increased. Urethral closure pressure decreased significantly.
D000368:Aged; D003558:Cystoscopy; D006801:Humans; D008297:Male; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D011312:Pressure; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000503:physiopathology; D001748:Urinary Bladder Neck Obstruction / Q000188:drug therapy* / Q000209:etiology; D014563:Urodynamics / Q000187:drug effects
D010643:Phenoxybenzamine