[System of pharmacologic control of histamine release by mast cells on exposure to different agents].
A scheme has been devised that makes it possible to assess a specific mechanism of action of any histamine-releasing agent. The scheme suggests a switch off of different stages of histamine secretion--interaction of a histamine liberator with surface cell receptors, entry of Ca2+ into the cell, temperature- and energy-dependent stages of histamine liberation, a stage that depends on microtubules, a system regulating histamine liberation with cyclic nucleotides. The scheme was made use of in clarification of the mechanism of histamine liberation on exposure of the mast cell to a specific antigen, to different doses of heavy metal salts, prednisolone and alkylating cross-binding agents.
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008407:Mast Cells / Q000378:metabolism*; D010165:Palladium / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010984:Platinum / Q000494:pharmacology; D017671:Platinum Compounds; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013696:Temperature; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000477:Alkylating Agents; D010936:Plant Extracts; D017671:Platinum Compounds; C030173:platinum chloride; C030174:tetrachloropalladium; D003189:p-Methoxy-N-methylphenethylamine; D010984:Platinum; D010165:Palladium; D004492:Edetic Acid; D011239:Prednisolone; D003078:Colchicine
Sistema farmakologicheskogo kontrolia protsessa vysvobozhdeniia gistamina tuchnykh kletok pri vozdeĭstvii razlichnykh agentov.