Central action of melanostatin (MIF-1) in mice.
The effects of MIF-1 administered into a lateral ventricle of the brain were studied on the behaviour of mice in the open field test and hole test, apomorphine-induced stereotypy, morphine-induced catalepsy, and reactivity on thermal painful stimuli in the hot plate test. The last test was compared with a similar test with morphine administration. It was demonstrated that MIF-1 exerted a depressing effect on the behaviour of mice, increased the intensity of apomorphine-induced stereotypy and weakened chlorpromazine-induced catalepsy. Moreover, an analgesic action of MIF-1 was demonstrated which was blocked with naloxone. The results of these investigations indicated a significant central action of MIF-1 in mice and a participation of dopaminergic receptors in certain effects of MIF-1 on the behaviour of experimental animals.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002375:Catalepsy / Q000503:physiopathology; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D007700:Kinetics; D009075:MSH Release-Inhibiting Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology; D013239:Stereotyped Behavior / Q000187:drug effects
D009270:Naloxone; D009075:MSH Release-Inhibiting Hormone; D001058:Apomorphine