title: Effect of adenosine-5'-triphosphate-3'-diphosphate and related nucleoside polyphosphates on the spore germination of Streptomyces galilaeus.
abstract: Exogenous addition of adenosine- and guanosine 5'-(di- and tri) phosphate 3'-diphosphate (pppApp, ppApp, pppGpp and ppGpp) at the concentration of 0.5 mM inhibits spore germination of Streptomyces galilaeus ATCC 31133. This reversible inhibitory effect appeared to be at the transcriptional level, and also depends on the phase of spore germination; pppApp inhibited more strongly RNA synthesis in the period of the germ tube emergence than the early stage of germination. No inhibitory effect was observed with normal purine and pyrimidine nucleosides, nucleotides, pApp, pGpp, cyclic AMP and pyrophosphoric acid at the concentration of 0.1 - 1.0 mM.
mesh_terms: D000227:Adenine Nucleotides / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000096:biosynthesis; D006150:Guanine Nucleotides / Q000494:pharmacology*; D006158:Guanosine Pentaphosphate / Q000494:pharmacology*; D006159:Guanosine Tetraphosphate / Q000494:pharmacology*; D009705:Nucleosides / Q000494:pharmacology; D011685:Purine Nucleotides / Q000494:pharmacology; D011742:Pyrimidine Nucleotides / Q000494:pharmacology; D012329:RNA, Bacterial / Q000096:biosynthesis; D013171:Spores, Bacterial / Q000187:drug effects / Q000502:physiology; D013302:Streptomyces / Q000187:drug effects* / Q000502:physiology
chemical_list: D000227:Adenine Nucleotides; D004269:DNA, Bacterial; D006150:Guanine Nucleotides; D009705:Nucleosides; D011685:Purine Nucleotides; D011742:Pyrimidine Nucleotides; D012329:RNA, Bacterial; D006159:Guanosine Tetraphosphate; D006158:Guanosine Pentaphosphate; C011626:adenosine 5'-triphosphate 3'-diphosphate