T cells in a suppressor circuit and non-T:non-B cells bear different I-J determinants.
T cells involved in the generation of suppressor activity bear an I-J-subregion controlled determinant (e.g., J1) which is distinct from that (e.g., J2) found on non-T:non-B accessory cells. T-cell subsets examined include Ly-1 inducer and Ly-1,2 acceptor cells which collaborate to generate suppressor activity in the in vitro sheep red blood cell antibody system. Non-T:non-B accessory cells examined include accessory cells involved in concanavalin-A induced, T-cell proliferative responses and in in vitro antibody responses to sheep red blood cells. These results provide evidence for serologic and genetic complexity of the I-J subregion of the murine H-2 gene complex.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D003208:Concanavalin A / Q000494:pharmacology; D000939:Epitopes; D007518:Isoantibodies; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D008215:Lymphocytes, Null / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000950:Antigens, Ly; D000939:Epitopes; D007518:Isoantibodies; D003208:Concanavalin A