Ciclindole and flucindole: novel tetrahydrocarbazolamine neuroleptics.
The tryptamine derivatives ciclindole and flucindole elevated striatal dopamine metabolites in the rat and mouse. These agents also displace [3H]spiperone binding in vitro. These data indicate that these tryptamine derivatives represent novel neuroleptic structures.
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002227:Carbazoles / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D002227:Carbazoles; C029514:flucindole; C014432:cyclindole; D006220:Haloperidol; D004298:Dopamine