title: Immunolocalization of fetal aldolase isoenzymes in rat regenerating liver after carbon tetrachloride intoxication.
abstract: Light and electron microscopic immunolocalization of adult and fetal aldolase isoenzymes has been studied in rat liver 72 h after CCL4 intoxication. As in rat regenerating liver after partial hepatectomy, fetal aldolases A and C were located in sinusoidal cells (Kupffer and endothelial cells) whereas adult aldolase B was present in hepatocytes only. Our results are different from those obtained with fetal and cancerous livers; they suggest that control mechanisms of gene regulation different in liver regeneration and in cancer.
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005634:Fructose-Bisphosphate Aldolase / Q000032:analysis*; D007527:Isoenzymes / Q000032:analysis; D008099:Liver / Q000196:embryology / Q000201:enzymology* / Q000648:ultrastructure; D008115:Liver Regeneration; D008297:Male; D011247:Pregnancy; D051381:Rats; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D007527:Isoenzymes; D000509:alpha-Fetoproteins; D005634:Fructose-Bisphosphate Aldolase