Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice.
Suckling Swiss mice were injected daily for 8 days with either electrophoretically pure (EP) mouse interferon (s.a. 4.7 x 10(8) units/mg protein), major impurities obtained in the course of purification, or partially purified mouse interferon (s.a. 1.3 x 10(7) units/mg protein). Only EP or partially purified interferon inhibited growth, induced liver and kidney lesions, and killed mice. The authors conclude that interferon itself is responsible for these effects.
D000828:Animal Population Groups / Q000254:growth & development*; D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development*; D004586:Electrophoresis; D005921:Glomerulonephritis / Q000209:etiology; D006651:Histocytochemistry; D007372:Interferons / Q000302:isolation & purification / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D008099:Liver / Q000187:drug effects; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology; D051379:Mice; D013997:Time Factors
D007372:Interferons