Modification of 3-hydroxy-3-methylglutaryl coenzyme A reductase immunoinhibition curves by substrates and inhibitors. Evidence for conformational changes leading to alterations in antigenicity.
D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D000939:Epitopes / Q000032:analysis*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000276:immunology / Q000378:metabolism*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007700:Kinetics; D008148:Lovastatin / Q000031:analogs & derivatives; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009281:Naphthalenes / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000939:Epitopes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009281:Naphthalenes; C012258:mevastatin; D008148:Lovastatin; D006903:Hydroxymethylglutaryl CoA Reductases