Humoral immune system and ulcerative colitis activity. III. Immune complexes.
Serum immune complexes (IMC) were examined by means of 4.166% polyethylene glycol precipitation. IMC were found in 33.3% of all examined patients (12.8% of inactive and 51.1% of active colitis). Polyethylene glycol serum precipitation was correlated with the activity of the disease, and was found to be increased in patients with extensive morbid process and with duration of the disease. In the patients with extraintestinal manifestations IMC increased particularly in those with skin lesions. Our study confirmed suggestion of other authors on the possible role of the pathogenesis of UC and in extraintestinal complications. Their secondary role however, cannot be excluded.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012460:Sulfasalazine / Q000627:therapeutic use
D000936:Antigen-Antibody Complex; D012460:Sulfasalazine