CSF monoamine metabolites in child and adult psychiatric patients. A developmental perspective.
Concentrations of acid metabolites of dopamine and serotonin were measured in lumbar CSF of a diagnostically heterogeneous group of 154 psychiatric patients following oral probenecid loading. The patients ranged in age from 2 to 67 years old. No patients had received psychoactive medications for at least two weeks prior to the lumbar puncture. Children had higher mean CSF homovenillic acid (HVA) levels, higher mean CSF HVA-probenecid ratios, higher CSF HVA-log probenecid ratios, and lower mean CSF probenecid levels than adults. Age was negatively correlated with CSF HVA level and with CSF HVA-probenecid ratio. These correlations were more pronounced in male patients than in female patients.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001321:Autistic Disorder / Q000134:cerebrospinal fluid; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D001523:Mental Disorders / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D010468:Perceptual Disorders / Q000134:cerebrospinal fluid; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D011339:Probenecid / Q000134:cerebrospinal fluid; D012559:Schizophrenia / Q000134:cerebrospinal fluid
D010648:Phenylacetates; D006897:Hydroxyindoleacetic Acid; D011339:Probenecid; D006719:Homovanillic Acid