title: Artificial eustachian tube-induced keratin foreign-body granuloma.
abstract: The pathogenesis of granulation tissue that arises periodically around artificial Eustachian tubes was elucidated by histologic examination of 15 cases of tube granuloma. All cases showed the presence of a keratin foreign-body granuloma. The implanted squames incited a foreign-body type of granulomatous reaction and produced a friable vascular exuberant mass that surrounded the artificial Eustachian tube. Histologically, the tube granuloma was characterized by the presence of irregular ovoid slit-like spaces that contained keratin squames, and it was surrounded by foreign-body giant cells.
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005064:Eustachian Tube; D005260:Female; D005547:Foreign Bodies / Q000150:complications*; D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007633:Keratins; D008297:Male; D019736:Prostheses and Implants / Q000009:adverse effects*
chemical_list: D007633:Keratins