Effect of corticosterone on serum concentrations of alpha 2 micro-globulin and on spermatogenesis in oestrogen-treated rats.
Treatment of adult male rats with oestradiol-17 beta (50 microgram/100 g body wt per day for 7 days) resulted 14 days later in reduced levels of alpha 2 micro-globulin in serum and inhibition of spermatogenesis. Administration of corticosterone (2 mg/day) for 14 days to oestrogen-treated rats raised the concentration of alpha 2 micro-globulin in the serum and prevented spermatogenic degeneration. It is concluded that endogenous alpha 2 micro-globulin induced by corticosterone may play a role in spermatogenesis in oestrogenized rats.
D000510:Alpha-Globulins / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012670:Seminiferous Epithelium / Q000187:drug effects / Q000473:pathology; D013091:Spermatogenesis / Q000187:drug effects*
D000510:Alpha-Globulins; C025500:alpha(2)-microglobulin; D004958:Estradiol; D003345:Corticosterone