title: Specific antigenic relationships between the RNA-dependent DNA polymerases of avian reticuloendotheliosis viruses and mammalian type C retroviruses.
abstract: Immunoglobulin G directed against the DNA polymerase of Rauscher murine leukemia virus (R-MuLV) could bind to 125I-labeled DNA polymerase of spleen necrosis virus (SNV), a member of the reticuloendotheliosis virus (REV) species. Competition radioimmunoassays showed the specificity of this cross-reaction. The antigenic determinants common to SNV and R-MuLV DNA polymerases were shared completely by the DNA polymerases of Gross MuLV, Moloney MuLV, RD 114 virus, REV-T, and duck infectious anemia virus. Baboon endogenous virus and chicken syncytial virus competed partially for antibodies directed against the common antigenic determinants of SNV and R-MuLV DNA polymerases. DNA polymerases of avian leukosis viruses, pheasant viruses, and mammalian type B and D retroviruses and particles with RNA-dependent DNA polymerase activity from the allantoic fluid of normal chicken eggs and from the medium of a goose cell culture did not compete for the antibodies directed against the common antigenic determinants of SNV and R-MuLV DNA polymerases. We also present data about a factor in normal mammalian immunoglobulin G that specifically inhibits the DNA polymerases of REV and mammalian type C retrovirus DNA polymerases.
mesh_terms: D000406:AKR murine leukemia virus / Q000276:immunology; D000818:Animals; D000956:Antigens, Viral; D000939:Epitopes; D007074:Immunoglobulin G; D008979:Moloney murine leukemia virus / Q000276:immunology; D012194:RNA-Directed DNA Polymerase / Q000276:immunology*; D011925:Rauscher Virus / Q000276:immunology; D001356:Reticuloendotheliosis virus / Q000201:enzymology / Q000276:immunology*; D012190:Retroviridae / Q000201:enzymology / Q000276:immunology*; D018894:Reverse Transcriptase Inhibitors
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D007074:Immunoglobulin G; D018894:Reverse Transcriptase Inhibitors; D012194:RNA-Directed DNA Polymerase