Abnormal behavioral effects elicited by a neurotropic mycotoxin, fumitremorgin A in mice.
Fumitremorgin A (FTA), a neurotropic mycotoxin induced dose-dependent abnormal behaviors, including tremor, clonic convulsion, kangaroo posture and tonic extensor convulsion in the mouse. FTA-induced tonic extensor convulsion was markedly suppressed by anticonvulsant, e.g. phenobarbital, phenytoin. Phenobarbital, trimethadione, valproic acid and mephenesin decreased the occurrence of abnormal behaviors induced by FTA. Although pentylenetetrazol-induced tonic extensor convulsion was not affected by antipsychotic drugs (dopaminergic drugs) except chlorpromazine, FTA-induced abnormal behaviors were inhibited by antipsychotic drugs, e.g. chlorpromazine, haloperidol. Chlordiazepoxide, diazepam and muscimol inhibited FTA-induced abnormal behaviors. These findings suggest that both dopaminergic and gamma-aminobutyric acid (GABA)-ergic systems are involved in FTA-induced abnormal behaviors. FTA-induced abnormal behaviors may be useful as a common experimental model for the primary evaluation of anticonvulsants, antipsychotic drugs and anxiolytic drugs.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D000978:Antiparkinson Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D006247:Harmine / Q000494:pharmacology; D007192:Indenes / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D051379:Mice; D009183:Mycotoxins / Q000633:toxicity*; D010433:Pentylenetetrazole / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced; D014202:Tremor / Q000139:chemically induced
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000978:Antiparkinson Agents; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D007192:Indenes; D009183:Mycotoxins; D011619:Psychotropic Drugs; D006247:Harmine; D010433:Pentylenetetrazole; C024743:Fumitremorgin A