Tallysomycin, a new antitumor antibiotic complex related to bleomycin. IV. New biosynthetic derivatives of tallysomycin.
A series of new biosynthetic derivatives of tallysomycins A and B were obtained by precursor amine-feeding fermentation. Certain diamines were incorporated into tallysomycins as the terminal amine moiety affording two classes of biosynthetic derivatives, with or without the Beta-lysine moiety in the subterminal position. Among 21 derivatives prepared, tallysomycin S10b was selected for further studies in view of its favorable therapeutic indices.
D000192:Actinomycetales / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001761:Bleomycin / Q000096:biosynthesis* / Q000494:pharmacology / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000378:metabolism; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D051379:Mice
D000903:Antibiotics, Antineoplastic; D003959:Diamines; D001761:Bleomycin; C016126:talisomycin