Effect of polychlorinated biphenyl on viral infections in mice.
Mice that were fed a diet containing 400, 200 or 100 microgram of polychlorinated biphenyls (PCB) per g were significantly more susceptible to Herpes simplex virus than mice that were fed a PCB-free diet. The mortality of mice that were fed a diet containing 400 or 200 microgram of PCB per g and infected with ectromelia virus was higher than that of normal control mice infected with virus. There was no significant difference in inducibility of interferon by polyinosinic acid-polycytoidylic acid between PCB-fed mice and control mice.
D000818:Animals; D004482:Ectromelia, Infectious / Q000401:mortality*; D006561:Herpes Simplex / Q000401:mortality*; D007372:Interferons / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011070:Poly I-C; D011078:Polychlorinated Biphenyls / Q000378:metabolism / Q000494:pharmacology*; D011213:Poxviridae Infections / Q000401:mortality*; D013997:Time Factors
D007372:Interferons; D011078:Polychlorinated Biphenyls; D011070:Poly I-C