Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N-sulfate content.
Addition of chlorosulfonyl isocyanate to C==C bonds in cis-1,4-polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water-soluble polyelectrolyte with N-sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N-sulfate content.
D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D055598:Chemical Phenomena; D002621:Chemistry; D006496:Heparinoids / Q000032:analysis / Q000494:pharmacology*; D006801:Humans; D008970:Molecular Weight; D013431:Sulfates / Q000032:analysis; D013918:Thrombin Time; D014783:Viscosity
D006496:Heparinoids; D013431:Sulfates