Blood levels of proteinase inhibitors in pregnancy.
Plasma volume, serum alpha 2-macroglobulin, alpha 1-antitrypsin, C1 inactivator and alpha 2-antiplasmin, and plasma antithrombin III were measured in 10 pregnant women at gestation periods of 12-14 and 37-38 weeks. The proteinase inhibitors were also measured in 10 non-pregnant healthy women. There was a significant increase in the alpha 1-antitrypsin concentration and significant decreases in alpha 2-macroglobulin and C1 inactivator, but the total circulating quantity of all the proteinase inhibitors was significantly increased.
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D003174:Complement C1 Inactivator Proteins / Q000097:blood; D005260:Female; D006801:Humans; D010953:Plasma Volume; D011247:Pregnancy; D011480:Protease Inhibitors / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D003174:Complement C1 Inactivator Proteins; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D000990:Antithrombin III