[Structure and biological properties of immunoglobulins and gamma-globulin preparations. II. Properties of gamma-globulin preparations].
Various gammaglobulin preparations have been analyzed with regard to content of IgG aggregates and percentage distribution of the four IgG subclasses. Their elimination from the plasma compartment was also studied in turnover experiments. Chief attention was focused on gamma-globulin preparations for intravenous use. The various preparations clearly differed in their subclass composition and metabolic behaviour. At present these results allow no conclusions concerning the efficacy of the various preparations in severe bacterial infections, since controlled clinical trials are still lacking. They should, however, be borne in mind when selecting a gammaglobulin preparation for a planned clinical trial.
D006801:Humans; D005719:gamma-Globulins / Q000145:classification / Q000276:immunology* / Q000627:therapeutic use
D005719:gamma-Globulins
Struktur und biologische Eigenschaften von Immunglobulinen und gamma-Globulin-Präparaten. II. Eigenschaften von gamma-Globulin-Präparaten.