title: Sensory environments, brain damage, and drugs: a review of interactions and mediating mechanisms.
abstract: The sensory environment appears to play a greater role than was previously appreciated in the etiology of, and recovery from, brain damage. This paper reviews the interaction between brain damage and complex and deprived environments, the nature of mechanisms which may mediate these effects, and the studies of stimulant drug effects on these processes. It is suggested that our traditional concepts of causation and mediating mechanisms have been overly simple and that we need to move to a more holistic multidimensional interactive perspective.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001143:Arousal; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000209:etiology* / Q000473:pathology; D002540:Cerebral Cortex / Q000032:analysis / Q000473:pathology; D002802:Cholinesterases / Q000378:metabolism; D004247:DNA / Q000032:analysis; D006801:Humans; D007858:Learning; D009929:Organ Size; D012313:RNA / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012683:Sensory Deprivation; D012934:Social Isolation
chemical_list: D012313:RNA; D004247:DNA; D000110:Acetylcholinesterase; D002802:Cholinesterases