Evidence for the contribution by the cerebral cortex to 5-hydroxyindoleacetic acid found in the cerebrospinal fluid of cats.
Perfusion of artificial CSF from a lateral ventricle to the cerebral cortical subarachnoid space in anaesthetized cats was used to study the contribution of the cerebral cortex to the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in CSF. The technique did not cause rupture of the meninges. The use of [14C]5-HIAA and of probenecid suggested that there was a contribution and also a transport mechanism similar to that in the choroid plexus.
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000502:physiology*; D002831:Choroid Plexus / Q000502:physiology; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D013346:Subarachnoid Space / Q000502:physiology
D006897:Hydroxyindoleacetic Acid