Investigations on the chromosomal localizations of the human and chimpanzee interferon genes: possible role of chromosomes 9 and 13.
Analysis of a great number of independent hamster-human and mouse-chimpanzee somatic cell hybrid clones confirms the role of chromosome 9 as carrying one or more primate beta interferon genes. The presence of chromosome 13 in producing hybrids and its absence in all non producing clones must be kept in mind for future studies. The strong negative regulation of interferon production in the parental hamster cells also affects the human gene product. The UV irradiation target for these regulatory genes is significantly greater than the structural genes responsible for interferon production.
D000818:Animals; D002901:Chromosomes, Human, 13-15 / Q000032:analysis*; D002906:Chromosomes, Human, 6-12 and X / Q000032:analysis*; D006224:Cricetinae; D006801:Humans; D007372:Interferons / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D002679:Pan troglodytes / Q000235:genetics*
D007372:Interferons