[Development of behavioral function of cerebellar hypoplasia rats as induced by cytosine arabinoside (ara-C) (author's transl)].
Cytosine arabinoside (ara-C), an antiproliferative agent, was given subcutaneously to Sprague-Dawley rats on the 2-4th postnatal day in doses of 12.5 and 25 mg/kg/day. Body weight and viability were found to be dose-dependently inhibited. The appearance of audio-startle response was delayed in the group on the high dose and up to 21 days of age, the ambulatory behavior resembled that seen in geriatric rats. The free-fall righting reflex failed to appear in the treated groups. The open field test revealed that only the treated females were hypoactive. The treated group showed a poor neuro-muscular ability in the rotarod performance and impairment of acquiring conditioned and unconditioned avoidance response in pole climbing. Histopathological and biochemical studies revealed a hypoplasia of the cerebellum. These findings are suggestive of behavioral dysfunction caused by ara-C-induced cerebellar disorders.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002531:Cerebellum / Q000032:analysis / Q000187:drug effects / Q000473:pathology*; D002540:Cerebral Cortex / Q000032:analysis; D003561:Cytarabine / Q000633:toxicity*; D004247:DNA / Q000032:analysis; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D012313:RNA / Q000032:analysis; D051381:Rats
D003561:Cytarabine; D012313:RNA; D004247:DNA