Marked enhancement of antibody synthesis following immunization with antigen bound to host lymphocytes. A potential treatment of patients with allergy.
Immunization of rabbits with I ugm of the gammaglobulins in goat anti-rabbit immunoglobulin antiserum (GG-GARIG) immunologically bound to circulating rabbit lymphocytes results in a humoral immune response to normal goat gammaglobulin (NGGG) super to that induced following repeated immunization with 10 mg GG-GARIG or NGGG. This form of immunization can only be carried out with antigen bound to cells possessing receptors for the antigen. Such a situation exists with respect to the allergic individual who possesses circulating lymphocytes capable of interacting with the specific allergen. It is suggested that desensitization or immunotherapy of the allergic individual with the allergen immunologically bound to autologous lymphocytes will result in extensive formation of IgG blocking antibodies unaccompanied by an anaphylactic reaction in view of the very minute quantity of allergen administered.
D000327:Adsorption; D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects; D000941:Antigens; D004912:Erythrocytes / Q000276:immunology; D006041:Goats; D006967:Hypersensitivity / Q000628:therapy*; D007106:Immune Sera / Q000494:pharmacology; D007114:Immunization; D007136:Immunoglobulins / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D011817:Rabbits; D005719:gamma-Globulins / Q000276:immunology
D000941:Antigens; D007106:Immune Sera; D007136:Immunoglobulins; D005719:gamma-Globulins