title: Metallothionein present or induced in the three species of frogs Bombina orientalis, Bufo bufo japonicus and Hyla arborea japonica.
abstract: A low molecular weight copper (Cu)- and/or zinc (Zn)-binding protein was present in the livers (and kidneys) of the three species of frogs Bombina orientalis, Bufo bufo japonicus and Hyla arborea japonica. Cadmium (Cd) accumulated in the livers (and kidneys) after repeated i.m. injections of Cd2+ was mostly bound to the same metal-binding protein as Cd, Zn- or Cd, Zn, Cu-thionein. Concentrations of Cd and several essential elements in the livers and kidneys of the three species of frogs were determined by inductively coupled plasma-atomic emission spectrophotometry. Metallothionein in the three species of frogs consists of a single isoform both in control and Cd-injected animals.
mesh_terms: D000818:Animals; D001001:Anura; D002023:Bufo bufo; D002104:Cadmium / Q000494:pharmacology; D003300:Copper / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism*; D011892:Rana catesbeiana; D013045:Species Specificity; D014982:Xenopus laevis; D015032:Zinc / Q000378:metabolism
chemical_list: D002104:Cadmium; D003300:Copper; D008668:Metallothionein; D015032:Zinc