[Effect of an infusion with middle molecular weight hydroxyethyl starch (HAES-steril 10%) on the flow properties of blood in healthy probands].
Ten healthy volunteers received infusions of 500 ml of a 10% solution of middle-molecular-weight hydroxy-ethyl-starch (HES 200, HAES-steril 10%) within 30 min. Measurements of hemorheological parameters before and up to 3 hrs after infusion revealed a statistically significant decrease of whole-blood viscosity and a slight, but also statistically significant increase of plasma viscosity. RBC filterability and RBC aggregation remained unchanged. The data presented show that despite of a relatively high molecular weight of the infused HES-solution which is responsible for the relatively long intravascular persistence, the flow properties of blood as a whole are positively influenced.
D000328:Adult; D001799:Blood Sedimentation; D001809:Blood Viscosity / Q000187:drug effects*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D008970:Molecular Weight; D012212:Rheology; D013213:Starch / Q000031:analogs & derivatives*
D006895:Hydroxyethyl Starch Derivatives; D013213:Starch
Untersuchung über dex Einfluss einer Infusion von mittelmolekularer Hydroxyäthylstärke (HAES-steril 10%) auf die Fliesseigenschaften des Blutes gesunder Probanden.