Killer T cell responses to influenza A during a drift period: studies in mice.
After intravenous immunization of mice with any influenza A H3N2 drift strain attempts to restimulation of cytotoxic T cell (CTL) activities with the same virus or other drift period variants were unsuccessful for up to 6 weeks. Cross-stimulation 4-5 months after primary sensitization yielded, in most situations, positive but lower--as compared to primary--secondary cytotoxic T cell responses. Homotypic challenge was also effective after priming with some influenza A subtypes (A/E/72, A/PC/73, A/T/77) at this time.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D007117:Immunization, Secondary; D007156:Immunologic Memory; D009980:Influenza A virus / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors
D000956:Antigens, Viral; D000939:Epitopes