Effect of Epomediol on the ATPase and adenylate cyclase activities in plasmamembranes isolated from rat liver.
The effect of Epomediol (Clesidren (R)) on the membrane ATPase and Adenylate Cyclase activities has been investigated using highly purified rat liver plasmamembranes. The drug, even at micromolar concentration, showed a significant stimulatory effect on Ca++/Mg++- ATPase, Ca++- ATPase and Adenylate Cyclase activities. In particular the effect on Ca++- ATPase activity suggests that the drug under study may favourably modulate the calcium intracellular homeostasis.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*
D019086:Bridged Bicyclo Compounds, Heterocyclic; D002756:Cholagogues and Choleretics; D008565:Membrane Proteins; D013729:Terpenes; D012969:Sodium Fluoride; D005934:Glucagon; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D000262:Adenylyl Cyclases; D000252:Calcium-Transporting ATPases; C031365:epomediol