[Antiviral treatment of subacute sclerosing panencephalitis].
The natural outcome of SSPE which is as a rule unfavourable independently of the treatment given, and this indicates the necessity of studies on new methods of treatment. After failures of steroids, immunosuppressants and transfer factor the treatment with virostatic drugs seems to be most safe and justified. The paper contains preliminary results of clinical observations of 34 patients with SSPE treated with amantadine, ITF (a derivative of isothiazole) and isoprinosine. In some cases it was tried to correlate the results of treatment with those of immunological and electrophysiological investigations. The presented data are insufficient for a reliable conclusion to be drawn concerning the effect of various drugs on the course of SSPE, nevertheless, it seems that the best results with slowing down of the progression of the disease were observed in the group treated with isoprinosine.
D000293:Adolescent; D000328:Adult; D000547:Amantadine / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007542:Inosine Pranobex / Q000627:therapeutic use; D008297:Male; D013190:SSPE Virus / Q000187:drug effects; D013344:Subacute Sclerosing Panencephalitis / Q000188:drug therapy*; D013844:Thiazoles / Q000627:therapeutic use*
D000998:Antiviral Agents; D013844:Thiazoles; D000547:Amantadine; D007542:Inosine Pranobex
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