A gamma and G gamma globin chain synthesis in BFU-E colonies from adult, newborn, and fetal subjects and from thalassemic patients.
The G gamma and A gamma content of Hb F produced in cultures of BFU-Es from the blood of normal fetuses, neonates, and adults was determined. The results show that erythroid progenitors produce A gamma and G gamma chains in a ratio characteristic of their ontogenic stage. The analysis of the G gamma/A gamma ratio in culture of BRU-Es from thalassemic patients showed a marked heterogeneity, resembling that observed in freshly drawn cells. These results afford evidence that the type of gamma chain produced is programmed at the level of early erythroid progenitors.
D000328:Adult; D004912:Erythrocytes / Q000196:embryology / Q000502:physiology*; D005319:Fetal Hemoglobin / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D005333:Fetus / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000196:embryology / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D013789:Thalassemia / Q000097:blood* / Q000235:genetics
D005319:Fetal Hemoglobin