Long-term effects of minoxidil therapy on renal function of patients with refractory hypertension: the significance of albuminuria.
The addition of minoxidil therapy reduced blood pressure effectively for 6--52 months (average, 24) in 25 of 28 patients with refractory hypertension. One patient was nonresponsive; 2 were noncompliant. Patients who had a serum creatinine up to 4 mg% and greater than 750 mg of albuminuria per day had further deterioration of renal function of 5.3 +/- 1.4% per month compared to that of 0.2 +/- 0.4% per month in patients without albuminuria (p less th5% was not as helpful predicting preservation of renal function in patients with refractory hypertension after adding minoxidil as was the absence of albuminuria.
D000328:Adult; D000419:Albuminuria / Q000150:complications*; D001794:Blood Pressure / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007677:Kidney Function Tests; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000627:therapeutic use*; D009393:Nephritis / Q000150:complications; D011743:Pyrimidines / Q000627:therapeutic use*; D006435:Renal Dialysis
D011743:Pyrimidines; D008914:Minoxidil; D003404:Creatinine