[Evolution of the storage site of iron-dextran after retrograde axonal transport in the rat central nervous system (author's transl)].
The uptake, transport, and storage of an iron-dextran complex (used as a neuroanatomical tracer in the nigrostriatal pathway of rat) by neurons of the CNS is described. The complex is taken up by endocytosis and transported by lysosomes. Some iron-containing mitochondria are observed within the nigral cell bodies. The neuronal labelling remains for 10 days. Thereafter, the iron labelling of neurons decreases. No important neuronal degeneration is observed as a result of iron toxicity. The iron lost by neurons is taken up by glial cells. It is converted into ferritin and increases the intracerebral endogenous iron content.
D000818:Animals; D001370:Axonal Transport; D001921:Brain / Q000378:metabolism*; D004705:Endocytosis; D007501:Iron / Q000032:analysis; D007505:Iron-Dextran Complex / Q000378:metabolism*; D008928:Mitochondria / Q000032:analysis; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D007505:Iron-Dextran Complex; D007501:Iron
Evolution du lieu de stockage du dextran-fer transporté par le flux axonal rétrograde dans le système nerveux central du rat.