[Isolation of strain-specific and cross-reacting antibodies to influenza virus hemagglutinins from heterogenous populations of hyperimmune influenza sera].
A population of monoreceptor cross-reacting antibodies to a common antigenic determinant H1.1 present on the surface of hemagglutinin molecules of H0, H1 and Hsw1 subtypes has been isolated from a heterogenous population of antihemagglutinating antibodies of influenza hyperimmune sera. Selective adsorption yields highly active strain-specific sera to HA of A/FM/1/47 and A/Netherlands/36/56 viruses. Populations of strain-specific antibodies to HA of A/Moscow/Pan/52 and A/USSR/090/77 viruses were found to be identical, attesting to the complete similarity of the antigenic composition of HA of these viruses. The hyperimmune serum of A/Brazil/11/78 virus was found to contain a population of strain-specific antibodies different from HA of other H1N1 viruses studied. This shows that drift variants of A/USSR/090/77 virus appeared in 1978.
D000818:Animals; D000914:Antibodies, Viral / Q000302:isolation & purification*; D000918:Antibody Specificity; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis; D006389:Hemagglutinins, Viral / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology*; D011817:Rabbits; D013045:Species Specificity
D000914:Antibodies, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral; D007106:Immune Sera
Vydelenie shtammospetsificheskikh i perekrestno reagiruiushchikh antitel k gemaggliutininam virusov grippa iz geterogennykh populiatsiĭ protivogrippoznykh giperimmunnykh syvorotok.