Changes in the serotonin and 5-hydroxyindoleacetic acid contents in rat brain after ethanol and disulfiram treatments.
Disulfiram (700 mg/kg, p.o.) significantly increased the brain levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rats. Ethanol (1 g/kg and 2 x 1.5 g/kg, i.p.) did not affect the 5-HT level, but at the higher dose it significantly increased the 5-HIAA level. When disulfiram was given in combination with ethanol, the brain level of 5-HT was significantly higher and, conversely, the 5-HIAA level was significantly lower, as compared to the results with disulfiram alone. These results suggest that the biogenic aldehyde derived from 5-HT may influence 5-HT metabolism and the elimination of 5-HIAA from the brain.
D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004221:Disulfiram / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D066298:In Vitro Techniques; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis; D051381:Rats; D012701:Serotonin / Q000032:analysis* / Q000378:metabolism
D012701:Serotonin; D000431:Ethanol; D006897:Hydroxyindoleacetic Acid; D000445:Aldehyde Oxidoreductases; D008995:Monoamine Oxidase; D004221:Disulfiram