The combined effect of interferon and methotrexate on human osteosarcoma and lymphoma cell lines.
Two human osteosarcoma cell lines and 1 human lymphoblastoid cell line were tested for the growth inhibitory effect of methotrexate and human leukocyte interferon, both separately and in various combinations. Both agents inhibited the cell lines. No synergistic, inhibitory or blocking effects on tumor cell growth were detected.
D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D007372:Interferons / Q000008:administration & dosage / Q000494:pharmacology*; D008223:Lymphoma / Q000473:pathology*; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology*; D012516:Osteosarcoma / Q000473:pathology*
D007372:Interferons; D008727:Methotrexate