Postoperative function of "free" jejunal transplants for replacement of the cervical esophagus.
The postoperative function of "free" jejunal autotransplants for replacement of the pharyngoesophagus after palliative resection was evaluated in nine patients using clinical assessment, cinefluoroscopy, manometry, and electrical studies. After an initial period of adjustment, all patients swallowed solids and liquids with minimal difficulty, gained weight appropriately and were satisfied with their operations. Cinefluoroscopy and esophageal manometry demonstrated normal function of the intact distal esophagus, which correlated with the absence of reflux symptoms. The grafts were capable of contraction in response to local distension and maintained an intrinsic myoelectrical activity. These results indicate that jejunal autotransplantation may provide excellent palliation with restoration of a near normal swallowing mechanism for patients with large resectable lesions of the pharyngoesophagus. An additional observation was that the instillation of food directly into the gastric antrum caused a change in the motor activity in the transplantd jejunum, indicating physiological hormonal control of intestinal motility.
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D003679:Deglutition; D004938:Esophageal Neoplasms / Q000601:surgery; D004947:Esophagus / Q000502:physiology / Q000601:surgery*; D005260:Female; D006801:Humans; D007583:Jejunum / Q000637:transplantation*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009119:Muscle Contraction; D010166:Palliative Care; D014182:Transplantation, Autologous