Multiple low-dose tolerance to human gamma globulin: respective roles of T-cell suppression and direct T-helper paralysis.
Spleen cells of mice rendered tolerant to human gamma globulin tolerogen by multiple low-dose injections were transferred with immune spleen cells into syngeneic irradiated recipients, then challenged with immunogen. The suppressive effect of the spleen from tolerant animals was abolished by anti-Lyt-2 + C' treatment, which enabled also purified T cells to deliver a certain amount of help to immune B cells. It is therefore suggested that, at least in CBA strain, part of the T-cell tolerance depends upon continuous suppressor T-cell action in this system. Nevertheless, part of the functional incapacity of the helper population is probably due to direct paralysis. Thus both suppression and clonal inactivation are involved in multiple low-dose tolerance.
D000818:Animals; D005260:Female; D007108:Immune Tolerance; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology*
D005719:gamma-Globulins