title: Interactions of antineoplastic antibiotics and DNA.
abstract: Basic concepts of interaction of antineoplastic antibiotics with DNA are discussed and information concerning the effects of actinomycins, olivomycin and related antibiotics, anthracyclines, sibiromycin, mitomycin C, bruneomycin, and bleomycin is summarized.
mesh_terms: D000617:Aminoglycosides; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D001761:Bleomycin / Q000378:metabolism; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis* / Q000235:genetics; D003609:Dactinomycin / Q000378:metabolism; D006027:Glycosides / Q000378:metabolism; D006801:Humans; D008937:Mitomycins / Q000378:metabolism; D009279:Naphthacenes / Q000378:metabolism; D009848:Olivomycins / Q000378:metabolism; D013308:Streptonigrin / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D000903:Antibiotics, Antineoplastic; D006027:Glycosides; D008937:Mitomycins; D009279:Naphthacenes; D001761:Bleomycin; C100298:sibiromycin; D003609:Dactinomycin; D013308:Streptonigrin; D009848:Olivomycins; D004247:DNA