The psychopharmacological treatment of obsessive-compulsive disorder: a review.
This article reviews the literature concerning obsessive-compulsive disorder (OCD) and its treatment with drugs. We survey the differential diagnosis of OCD and the problems involved in evaluating its severity in a research setting. Pharmacological treatment of OCD has usually involved antidepressants, especially clomipramine, with equivocal but nevertheless encouraging success. Anxiolytic and neuroleptics have also been tried, but the results are inconsistent. We discuss the implications of these findings for treatment of patients with OCD and for future research.
D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000009:adverse effects / Q000627:therapeutic use; D004311:Double-Blind Method; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D009661:Nortriptyline / Q000627:therapeutic use; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D011569:Psychiatric Status Rating Scales
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D006897:Hydroxyindoleacetic Acid; D009661:Nortriptyline; D002997:Clomipramine