[Diaplacental influence on the disseminated intravascular coagulation (DIC) in an asphyxia model. II. Influence on the vessel's content (author's transl)].
There is reported on the possibilities of diaplacental influencing on the DIC arising from the hypoxia we provoked with the help of an asphyxia model in rabbit fetuses. We could demonstrate the impossibility of influencing on the fetal vasal content by means of low molecular dextran, heparin or streptokinase. On the contrary, the possibility exists to influence on the fetal hemostasis by low molecular synthetic substances. The antifibrinolytic drug PAMBA causes in case of advanced acidosis diaplacental a definite growth of the intravascular coagulation, as well. But an inhibition of the fibrin sedimentation in the terminal vessels at the asphyctic shock can be achieved by applying the ethyl ester of the 4-amidinophenylpyruvic acid (APPA).
D010129:4-Aminobenzoic Acid / Q000627:therapeutic use; D000818:Animals; D003911:Dextrans / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D004952:Esters; D005260:Female; D005311:Fetal Hypoxia / Q000188:drug therapy*; D006493:Heparin / Q000627:therapeutic use; D008431:Maternal-Fetal Exchange; D010667:Phenylpyruvic Acids / Q000627:therapeutic use; D011247:Pregnancy; D011817:Rabbits; D013300:Streptokinase / Q000627:therapeutic use; D062366:para-Aminobenzoates
D003911:Dextrans; D004952:Esters; D010667:Phenylpyruvic Acids; D062366:para-Aminobenzoates; C006492:amidinophenylpyruvic acid; C015668:4-aminomethylbenzoic acid; D006493:Heparin; D013300:Streptokinase; D010129:4-Aminobenzoic Acid
Diaplazentare Einwirkung auf die disseminierte intravasale Gerinnung (DIC) im Asphyxiemodell II. Beeinflussung des Gefässinhaltes.