title: Limitations of amniography in the prenatal diagnosis of spina bifida.
abstract: A fetus with an open, noncystic myelomeningocele was detected at the 22nd week of gestation in a woman monitored for advanced maternal age. The lesion could not be demonstrated on amniography. In 13% of published reports amniography failed to detect significant spina bifida lesions. This false-negative rate seems related to the noncystic nature of some neural tube defects at midgestation.
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005260:Female; D005332:Fetoscopy; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016136:Spina Bifida Occulta / Q000175:diagnosis*; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins