Interferon induces an antiviral state in ganglioside-deficient transformed mouse fibroblasts.
The antiviral activity of mouse fibroblast interferon against vesicular stomatitis virus was investigated in L-929 mouse fibroblasts and the ganglioside-deficient L-929 mutant cells (ATCC clone NCTC 2071). Although it has been widely reported that gangliosides serve as primary receptors for interferon at the cellular membrane, only a small difference in interferon sensitivity was observed between the wild-type L-929 and the ganglioside-deficient NCTC 2071 cells. It was not possible, however, to overcome this difference by administration of exogenous gangliosides.
D000818:Animals; D002472:Cell Transformation, Viral; D005347:Fibroblasts / Q000378:metabolism; D005732:Gangliosides / Q000378:metabolism*; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D009154:Mutation; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects
D005732:Gangliosides; D007372:Interferons