Relationship between polyamine accumulation and RNA biosynthesis and content during the cell cycle.
Polyamine accumulation was related to RNA biosynthesis and content during the cell cycle of CHO-K1 and HeLa cells. The highest correlations were observed between polyamine accumulation and RNA content. Feeding, serum-starved cultures of embryonic chick fibroblasts, which exhibit a 3-fold increase in RNA content, demonstrated that RNA content was most closely paralleled by spermidine content.
D000818:Animals; D002453:Cell Cycle; D002478:Cells, Cultured; D002642:Chick Embryo; D006224:Cricetinae; D005347:Fibroblasts / Q000378:metabolism; D006367:HeLa Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
D011073:Polyamines; D013096:Spermine; D012313:RNA; D013095:Spermidine; D011700:Putrescine