[Antiarrhythmic effect and influence on myocardial contractile function of the preparation, mexitil].
Complex clinical instrumental examination of 30 patients with disorders of cardiac rhythm and experimental study on 49 albino rats with induced transitory coronary insufficiency of various duration which were then subjected to reperfusion showed that Mexitil is an effective anti-arrhythmic agent in the treatment of ventricular disorders of rhythm and that during long-term treatment wih it inotropic myocardial function diminishes insignificantly; treatment produced positive results in 73% of patients.
D000328:Adult; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D011437:Propylamines / Q000627:therapeutic use*; D051381:Rats
D011437:Propylamines; D008801:Mexiletine
Antiarritmicheskiĭ éffekt i vliianie na sokratitel'nuiu funktsiiu miokarda preparata meksitila.