[Intranuclear alpha 1-antitrypsin in HBs-Ag-seronegative hepatitis B with PAS-negative globular hyaline bodies containing the complements components C4, C3, and C3-activator (author's transl)].
In the liver biopsy specimen of a 16 year old patient with HBsAg-seronegative hepatitis B PAS-negative globular hyaline bodies reacted with antibodies to the complement components C4, C3, and C3-activator, but not with antibodies to alpha 1-antitrypsin. However, alpha 1-antitrypsin could be identified in the liver cell nuclei, cytoplasm, and cell membrane. Probably, these findings are caused by an hereditary or acquired metabolic disorder.
D000293:Adolescent; D003166:Complement Activating Enzymes / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis*; D050577:Complement C3-C5 Convertases / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis*; D005260:Female; D006509:Hepatitis B / Q000201:enzymology / Q000276:immunology / Q000473:pathology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008856:Microscopy, Fluorescence; D013194:Staining and Labeling; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D003176:Complement C3; D003181:Complement C4; D006514:Hepatitis B Surface Antigens; D000515:alpha 1-Antitrypsin; D003166:Complement Activating Enzymes; D050577:Complement C3-C5 Convertases
Intranucleäres alpha 1-Antitrypsin bei HBsAg-seronegativer Hepatitis B mit PAS-negativen, die Komplementkomponenten C4, C3 und C3-Aktivator enthaltenden globulären hyalinen Körpern.