Chemotherapeutic trials with hamster mesothelioma 10-24: responses to azacitidine, aziridinylbenzoquinone, cisplatin, and PCNU.
Asbestos-induced peritoneal mesothelioma 10-24 serially transplanted in Syrian golden hamsters was used to test responses to seven drugs as single agents. Compared to saline-treated controls, the average survival time increased 51%-85% with azactitidine, 42%-60% with aziridinylbenzoquinone, 43% with cisplatin, and 35%-45% with PCNU. No cures were achieved. Therapeutic responses were not observed with dactinomycin, dianhydroxyanthracenedione, or DTIC.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001374:Azacitidine / Q000008:administration & dosage*; D001388:Aziridines / Q000008:administration & dosage*; D001389:Azirines / Q000008:administration & dosage*; D016227:Benzoquinones; D002945:Cisplatin / Q000008:administration & dosage; D006224:Cricetinae; D053138:Cyclohexenes; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D008297:Male; D008647:Mesocricetus; D008654:Mesothelioma / Q000188:drug therapy*; D009150:Mustard Compounds / Q000008:administration & dosage; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D013997:Time Factors
D000970:Antineoplastic Agents; D001388:Aziridines; D001389:Azirines; D016227:Benzoquinones; D053138:Cyclohexenes; D009150:Mustard Compounds; D009607:Nitrosourea Compounds; C006052:2,5-bis(1-aziridinyl)-3,6-bis(2-methoxyethoxy)-4-benzoquinone; C018627:1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidinyl)-1-nitrosourea; D001374:Azacitidine; D002945:Cisplatin