Monoclonal anti-deoxyribonucleic antibodies. I. Isotype and specificity studies.
Ten monoclonal anti-DNA antibodies generated in three separate fusion experiments performed using nonimmunized B/W spleen cells were studied. Their antigenic specificities were demonstrated to be identical and directed against a conformational determinant of the B helical form of double-stranded DNA (dsDNA). These data suggest that autoantibodies to dsDNA in B/W mice could constitute a homogeneous population.
D000818:Animals; D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D010584:Bacteriophage phi X 174 / Q000276:immunology; D001667:Binding, Competitive; D002459:Cell Fusion; D004247:DNA / Q000276:immunology*; D000939:Epitopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D051379:Mice; D008815:Mice, Inbred Strains; D011487:Protein Conformation
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D000939:Epitopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004247:DNA