title: Development of immunoreactive somatostatin in C-cell complexes in the thyroid gland of the dog.
abstract: In connection with our previous finding that an intense immunoreaction to somatostatin transiently appears in thyroid C cells of the dog during early fetal periods, the present study investigated C-cell complexes in thyroid glands from early fetuses to adults in an attempt to clarify whether the transient appearance of immunoreactivity to somatostatin is dependent on the degree of differentiation of C cells. C-cell complexes retain their fetal characteristics; even in the complexes of postnatal dogs, there are numerous undifferentiated cells, immature C cells and primitive follicular cells, which are not yet organized into follicles. Neither the degree of differentiation of C cells nor that of other constituent elements of the complexes affected the developmental pattern of somatostatin immunoreactivity in C cells. The C cells located in complexes displayed the same pattern of developmental changes in immunoreactivity to somatostatin as the cells in thyroid parenchyma. In the C-cell complexes of early fetal dogs a very intense immunoreactivity for somatostatin was observed; almost all calcitonin-positive cells were also somatostatin positive. The immunoreactivity to somatostatin progressively decreased with age. In the postnatal complexes the number of somatostatin-positive cells was very small compared with that of calcitonin-positive cells.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002116:Calcitonin / Q000378:metabolism; D002454:Cell Differentiation; D007124:Immunoenzyme Techniques; D013004:Somatostatin / Q000276:immunology / Q000378:metabolism*; D013961:Thyroid Gland / Q000166:cytology / Q000196:embryology / Q000378:metabolism*
chemical_list: D013004:Somatostatin; D002116:Calcitonin