Cellular growth in several organs of normal and dwarfed Snell mice.
The DNA, RNA and protein content of different organs was studied in Snell dwarf mice and compared with unaffected controls at different ages. The following organs were included: liver, kidneys, heart, submandibular salivary glands, spleen and thymus. In normal mice the rapid post-natal growth of all these organs is due to cell division and in the liver, kidneys, heart and submandibular salivary glands to cell enlargement as well. In dwarf mice weight of most organs studied is comparable with that of 1-2 weeks old normals. The data suggest no differences in cell size between dwarfs and normals in the liver, submandibular salivary glands, spleen and thymus, irrespective of age. In contrast, cell size of the heart and kidneys remains below the normal range and the RNA content is lowered as well. RNA is also low in the submandibular salivary glands and the liver, despite their normal protein content.
D000367:Age Factors; D000818:Animals; D004247:DNA / Q000378:metabolism; D004393:Dwarfism, Pituitary / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000254:growth & development; D007668:Kidney / Q000254:growth & development; D008099:Liver / Q000254:growth & development; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013154:Spleen / Q000254:growth & development; D013363:Submandibular Gland / Q000254:growth & development; D013950:Thymus Gland / Q000254:growth & development
D011506:Proteins; D012313:RNA; D004247:DNA