title: Sulphhydryl and disulphide stainings of amyloid: a comparison with hyaline body.
abstract: Histochemical staining for sulphhydryl (-SH) groups and disulphide (S-S) bonds was undertaken in 10 cases of cutaneous amyloidosis using the new fluorescent thiol reagent. A weak S-S fluorescence (but not -SH) was detected in dermal amyloid, suggesting that cross-linking of -SH groups may occur in amyloidogenesis. Since in normal skin S-S bonds were stained only in the horny layer and negligibly in the dermis, our findings seem to support the view that amyloid is derived at least partially from epidermal cells.
mesh_terms: D000682:Amyloid / Q000032:analysis*; D004220:Disulfides / Q000032:analysis*; D006801:Humans; D006818:Hyalin / Q000032:analysis; D008010:Lichen Planus / Q000473:pathology; D008301:Maleimides; D008856:Microscopy, Fluorescence; D012867:Skin / Q000473:pathology; D013194:Staining and Labeling; D013439:Sulfhydryl Reagents
chemical_list: D000682:Amyloid; D004220:Disulfides; D008301:Maleimides; D013439:Sulfhydryl Reagents; C019347:N-(7-dimethylamino-4-methylcoumarinyl)maleimide