Carcinoma of the lung with marked hyperamylasemia and elevated serum calcitonin.
Ectopic production of multiple peptide hormones is a frequent concomitant of neoplasia. An elderly man with metastatic small cell carcinoma of the lung presented with back pain, a right hilar mass, and was demonstrated to have markedly elevated serum calcitonin and amylase levels. Polyacrylamide gel electrophoresis revealed a striking elevation of a "salivary type" isoamylase. We report this case as an unusual association of production of both a peptide hormone and a nonhormonal peptide in a patient with a tumor of "neural crest" origin.
D000368:Aged; D000681:Amylases / Q000097:blood*; D002116:Calcitonin / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000201:enzymology; D006801:Humans; D007517:Isoamylase / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood* / Q000201:enzymology; D008297:Male
D002116:Calcitonin; D000681:Amylases; D007517:Isoamylase