[Changes in the rhythms of the alpha-fetoprotein content of the blood serum of mice with hepatoma 22A and of tumor cell proliferation depending on the time of cyclophosphane administration].
A study was made of the content of alpha-fetoprotein (alpha-FP) in the blood serum and of proliferative processes in hepatoma 22A-bearing mice after injection of cyclophosphamide in a dose of 150 mg/kg at varying time of 4-day tumor growth. The data obtained indicate that the time of appearance of alpha-FP in the blood, the pattern of rhythmic fluctuations in protein content and in the number of DNA-synthesizing and mitotic cells of the tumor depend on the time of the cytostatic injection during the day. Besides, cyclophosphamide exerts a more powerful inhibitory effect on the content of alpha-FP in the blood serum and less powerful on the proliferative processes in hepatoma 22A.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D008114:Liver Neoplasms, Experimental / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D051379:Mice; D010507:Periodicity; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins; D003520:Cyclophosphamide
Izmenenie ritmov soderzhaniia al'fa-fetoproteina v syvorotke krovi mysheĭ s gepatomoĭ 22A i proliferatsii kletok opukholi v zavisimosti ot vremeni vvedeniia tsiklofosfana.