Retinoic acid: enhancement of a tumor and inhibition of interferon's antitumor action.
The effect of trans-retinoic acid on the growth of P388 lymphoid tumors in inbred female DBA/2 mice in the presence or absence of interferon (FN) treatment was studied. This acid derivative of vitamin A enhanced local tumor growth. trans-retinoic acid also partially reversed IFN protection against tumor growth and mortality.
D000818:Animals; D002460:Cell Line; D005260:Female; D007372:Interferons / Q000037:antagonists & inhibitors*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy*; D013997:Time Factors; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin; D007372:Interferons