Block of axoplasmic transport in vitro by vinca alkaloids.
The three potent antimitotic vinca alkaloids: vincristine (VCR), vinblastine (VLB), and vindesine (VDS) were compared for their effect in blocking axoplasmic transport in vitro using a desheathed preparation of the peroneal branch of cat sciatic nerve. A range of vinca alkaloid concentrations from 1-100 microM was examined. The relative order of potency in blocking axoplasmic transport was VCR greater than VLB greater than VDS at a concentration of 25 microM. At the higher concentrations block occurred so rapidly that a statistically significant difference between these agents could not be obtained. The relation of vinca block to the transport mechanism is discussed.
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D002415:Cats; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008870:Microtubules / Q000378:metabolism; D010525:Peripheral Nerves / Q000187:drug effects*; D014747:Vinblastine / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000378:metabolism / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology
D014748:Vinca Alkaloids; D014750:Vincristine; D014747:Vinblastine