title: Substance P levels in the rat forebrain after apomorphine and haloperidol treatment.
abstract: The content of substance P(SP) in the rat forebrain was assayed by radioimmunoassay technique after apomorphine and haloperidol injection. Apomorphine (1 and 10 mg/kg) produced dose-dependent decrease in SP content, while haloperidol, 0.2 and 1 mg/kg produced a marked increase in SP level in the forebrain. The results may suggest a modulatory role for SP in the action of dopamine receptor agonists and antagonists.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013373:Substance P / Q000378:metabolism*
chemical_list: D011954:Receptors, Dopamine; D013373:Substance P; D006220:Haloperidol; D001058:Apomorphine