[Effect of oxygen on the antiviral activity of human interferon in cell culture].
Antiviral activity of human lymphocytic interferon under conditions of increased oxygen levels in the cell culture was studied. It was found that oxygen had a capacity for increasing the antiviral effect of human interferon in homologous cells. When 20-80% air was replaced by oxygen the interferon titers on an average amounted to 1:113.4-1:124.8 against 1:29.1 in the control. This means that the average titer of interferon in the experiments with oxygen was 4 times higher than that in the control. On the basis of these data it is recommended using interferon in the form of aerosols in conjunction with oxygen for the treatment of viral respiratory infections.
D002478:Cells, Cultured / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007369:Interferon Inducers; D007372:Interferons / Q000494:pharmacology*; D009522:Newcastle disease virus; D010100:Oxygen / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D007369:Interferon Inducers; D007372:Interferons; D010100:Oxygen
Vliianie kisloroda na protivovirusnuiu aktivnost' chelovecheskogo interferona v kul'ture kletok.