Adoptive transfer of delayed-type hypersensitivity to Sendai virus. IV. Influence of thymic and lymphohaematopoietic cell type on H-2 restriction specificity of T effector cells.
The intrathymic versus extrathymic influences on H-2-restriction specificity of K,D- and I-region-restricted Sendai virus-immune T lymphocytes, which mediate a delayed-type hypersensitivity response in vivo, were investigated. K,D- and I-region-restricted Td lymphocytes of P1 leads to F1 fetal liver chimeras showed preference but no absolute restriction for the P1 haplotype. T effector lymphocytes of thymic chimeras expressed a slightly higher degree of restriction for the haplotype of the thymus graft than F1 leads to P1 chimeras, which might reflect the activity of T lymphocytes of thymic origin. The lack of absolute restriction of both K,D- and I-region-restricted Td lymphocytes to the haplotype the thymus suggests an additional pathway of T-cell maturation.
D000818:Animals; D000939:Epitopes; D006183:H-2 Antigens; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation
D000939:Epitopes; D006183:H-2 Antigens