Effect of blood viscosity decrease on exercise ST segment depressions in hyperlipidemia.
In order to study the possible relation between blood viscosity and exercise ST segment depressions in hyperlipidemia the former was lowered by infusion of dextran and by treatment with clofibrate 1 g twice daily. Acute decrease of blood viscosity with dextran infusion in two cases increased the ST segment depressions during work. Nine subjects with asymptomatic hyperlipidemia, hyperfibrinogenemia and exercise ST segment depressions were treated with clofibrate in order to lower plasma fibrinogen and serum lipids. This did not influence the area of ST segment depression with either Frank leads or CH leads as determined by computer estimation. As the plasma fibrinogen level is of major importance for the blood viscosity it is concluded that the ischaemic ST segment depression seen in hyperlipidemia is not due to increased blood viscosity but more likely to a premature subclinical coronary atherosclerosis.
D001809:Blood Viscosity / Q000187:drug effects; D002986:Clinical Trials as Topic; D002994:Clofibrate / Q000627:therapeutic use; D003911:Dextrans / Q000627:therapeutic use; D005080:Exercise Test; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D008074:Lipoproteins / Q000097:blood
D003911:Dextrans; D008074:Lipoproteins; D005340:Fibrinogen; D002994:Clofibrate