Specific and non-specific stimulation of unprimed and primed lymphocytes induced by plane-tree allergenic extracts in rats.
Whole allergenic extracts (WAE) from plane-tree pollen induces in vitro blastogenesis in splenic lymphocytes from primed and normal rats. Allergen P, the major allergen of plane-tree pollen, induces an early stimulation in primed cells. WAE induced in the same way an early stimulation in primed cells, but a late incorporation of 3H-thymidine occurs at 8 days of culture when lymphocytes from primed or normal rats were used. This late response appears to be non-specific and is not abolished when a short-pulse of antigen is given.
D000485:Allergens / Q000276:immunology*; D000818:Animals; D000939:Epitopes; D005260:Female; D008213:Lymphocyte Activation; D051381:Rats; D013997:Time Factors; D014197:Trees / Q000276:immunology
D000485:Allergens; D000939:Epitopes