[Effect of etimizol on the RNA synthesizing activity of brain cell nuclei during the learning process in rats].
A study was made of the effect of the central nervous system stimulant ethymizol on RNA-polymerase activity of cell nuclei of the rat cerebral cortex and hippocampus during learning with different reinforcements. Ethymizol stimulated the incorporation of 3H-UTP in the TCA-insoluble fraction of hippocampal nuclei during training of the animals in the avoidance response to the light in a Y-shaped mize and training in the reaction of spontaneous alternation of food reinforcements in a complex mize, and decreased the ratio brain cortex/hippocampus RNA-polymerase activity. The data obtained are discussed from the standpoint that the action of ethymizol is consequent on the activation of the genome of nervous cells.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D003214:Conditioning, Classical / Q000187:drug effects*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005042:Etimizol / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D007093:Imidazoles; D012313:RNA; D012321:DNA-Directed RNA Polymerases; D005042:Etimizol
Vliianie étimizola na a RNK-sinterziruiushchuiu aktivnost' kletochnykh iader golovnogo mozgo v protsesse obucheniia u krys.