The effect of zinc on the sebum secretion rate.
In accordance with a randomized double-blind experimental design, capsules of zinc sulfate, 440 mg total daily dose, and lactose placebo were administered orally to 10 normal Caucasian males for 3 weeks. Sebum secretion rates and serum zinc levels were determined prior to and following treatment. There was a statistically significant change in the before and after mean sebum secretion rates of the zinc group when compared with those of the placebo group (p less than 0.028). The results of this preliminary study indicate that supplemental zinc sulfate may reduce the quantity of skin-surface sebum. Further investigation is warranted.
D000284:Administration, Oral; D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010919:Placebos; D011897:Random Allocation; D012629:Sebum / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D015032:Zinc / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D010919:Placebos; D015032:Zinc