The effect of parathyroid hormone (PTH) and 1,25 dihydroxy vitamin D3 (1,25(OH)2D3) on RNA and heme synthesis by erythroid precursors.
PTH was shown to stimulate RNA and heme synthesis in 12-13 days embryonic mouse liver erythroid cells, thus expressing an erythropoietin-like effect. Incubation of erythroid precursors with 1,25(OH)2D3 had no effect on heme synthesis, and increased the RNA synthesis only slightly, thus showing no enhancement effect of 1,25(OH)2D3 on the PTH stimulating effect on erythropoiesis.
D000818:Animals; D002117:Calcitriol; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004900:Erythroblasts / Q000187:drug effects* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects*; D004920:Erythropoiesis / Q000187:drug effects; D006418:Heme / Q000096:biosynthesis*; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000196:embryology; D051379:Mice; D010281:Parathyroid Hormone / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D006418:Heme; D012313:RNA; D002117:Calcitriol