Decrease in survival time in beta 2-adrenoceptor blocked cats exposed to bleeding.
Our previous investigations have indicated that beta 2-adrenergic regulatory mechanisms contribute to important compensatory hemodynamic adjustments in hemorrhage. In the present study an attempt was made to examine, by comparative observations after standardized fatal hemorrhage on cats with intact and 'selectively' blocked beta 2-adrenoceptors (ICI 118,551), whether such compensatory effects are crucial for survival. On the average, the survival time after bleeding was 686 min in cats with intact and 427 min in cats with blocked beta 2-adrenoceptors (p less than 0.05), the difference thus approaching 4.5 h. It is suggested that the reduced survival time after beta 2-blockade, at least partly, can be ascribed to interference with the circulatory beta 2-adrenergic control in hemorrhage aimed at improving tissue perfusion.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002395:Catecholamines / Q000097:blood; D002415:Cats; D005990:Glycerol / Q000097:blood; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects*; D006470:Hemorrhage / Q000097:blood / Q000401:mortality* / Q000503:physiopathology; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D010313:Partial Pressure; D011412:Propanolamines / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D002395:Catecholamines; D007773:Lactates; D011412:Propanolamines; D019344:Lactic Acid; C026777:ICI 118551; D005990:Glycerol