Characterization of the rat parotid beta-adrenoceptor.
1 The effects of various beta-adrenoceptor agonists on amylase secretion from the rat parotid gland were studied by means of two different in vitro techniques. 2 The dose-response relation for each agonist was established, as also were the ED50 values. 3 All drugs appeared to act directly on the acinar cells, as reserpine-treatment did not abolish their secretagogic effects. 4 Two groups of agonists could be distinguished: one group consisting of adrenaline, noradrenaline and the B1-selective agonist prenalterol (H133/22) with a high enzyme discharge potency and a second group consisting of the beta 2-agonists, terbutaline and salbutamol, with a markedly lower effect. 5 The present data further support the theory that rat parotid acinar cells are supplied mainly with beta-adrenoceptors of the beta 1-subtype, similar to those present in heart and adipose tissue.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D005260:Female; D010306:Parotid Gland / Q000378:metabolism*; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012110:Reserpine / Q000494:pharmacology; D014475:Uncoupling Agents / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D002395:Catecholamines; D004140:Dinitrophenols; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D014475:Uncoupling Agents; D012110:Reserpine; D000681:Amylases