title: Interferon action in human fibroblasts: induction of 2', 5'-oligoadenylate synthetase in the absence of detectable protein kinase activity.
abstract: In several strains of human fibroblasts, treatment with human alpha- or beta-interferon (IFN) resulted in an induction of 2', 5'-oligoadenylate synthetase but no protein kinase activity. The antiviral and anticellular effects of IFN are elicited in these cells in the absence of detectable IFN-induced protein kinase activity.
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase; D002460:Cell Line; D004686:Encephalomyocarditis virus / Q000254:growth & development; D004790:Enzyme Induction; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008574:Mengovirus / Q000254:growth & development; D009713:Nucleotidyltransferases / Q000096:biosynthesis*; D011494:Protein Kinases / Q000096:biosynthesis*; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development
chemical_list: D007372:Interferons; D011494:Protein Kinases; D009713:Nucleotidyltransferases; D015088:2',5'-Oligoadenylate Synthetase