title: Rapid AV nodal re-entrant tachycardias presenting with syncope or pre-syncope: use of electrophysiological studies to select therapy.
abstract: Five patients with recurrent syncope or pre-syncope due to rapid supraventricular tachycardias underwent electrophysiological study. In each patient, an AV nodal re-entrant tachycardia could be induced. By leaving a coronary sinus catheter in place, the effects of drugs on the ability to induce tachycardia could be tested on sequential days. Drug effects were highly variable, but in each patient it was possible to determine a drug which prevented induction of tachycardia. Patients treated with this drug have had no recurrent symptoms or tachycardias with a followup of 4-21 months. Although AV nodal re-entry is highly dependent on autonomic tone, electrophysiological study appears to be a useful means of selecting therapy in patients with severe, symptomatic tachycardias.
mesh_terms: D000328:Adult; D001283:Atrioventricular Node; D002304:Cardiac Pacing, Artificial; D004077:Digoxin / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D006801:Humans; D011433:Propranolol / Q000627:therapeutic use; D013575:Syncope / Q000209:etiology*; D013610:Tachycardia / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D004077:Digoxin; D011433:Propranolol