Treatment with xylometazoline (Otrivin) nosedrops over a six-week period.
Twenty healthy subjects were treated with xylometazoline 1 mg/ml for six weeks in order to study the occurrence of tachyphylaxis and rhinitis medicamentosa. Each subject instilled 0.15 ml of xylometaxoline nose-drops into each nostril three times a day. Posterior rhinomanometry was performed before the trial started, after 1, 2, 4 and 6 weeks treatment and 20, 27, 40 and 48 hours after the subject had taken the nose-drops for the last time. With rhinomanometry it was possible in this study to show that the same dose was adequate during the whole six-week period, i.e. no tachyphylaxis was observed. No reactive congestion was observed after the trial was finished.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000009:adverse effects*; D012220:Rhinitis / Q000139:chemically induced; D012903:Smell / Q000187:drug effects; D013618:Tachyphylaxis
D007093:Imidazoles; D014663:Nasal Decongestants; C009695:xylometazoline