Focal and generalized experimental seizures induced by homocysteine.
Electrocorticographic and behavioral effects of parenteral injections of homocysteine in rats are described. Homocysteine activates experimental foci and produces focal seizures in experimental animals with pre-existing lesions. It produces generalized ECoG seizures and generalized convulsions in unlesioned animals in higher doses.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006710:Homocysteine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012640:Seizures / Q000139:chemically induced*
D006710:Homocysteine