Changes in protein and RNA synthesis in rat brain neurons after a single dose of methylmercury.
Methylmercury was given to 30-day-old Wistar rats, At 1-7 days later the protein and RNA synthesis was studied in vivo by injecting a mixture [14C]leucine and [3H]uridine. Protein and RNA were precipitated from isolated cerebral and cerebellar neurons. The reduction of RNA synthesis coincides or precedes the reduced protein synthesis.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D008767:Methylmercury Compounds; D009419:Nerve Tissue Proteins; D012313:RNA