Effects of purine amino groups on the development of Drosophila.
The effect of a variety of 6-substituted purines on development of Drosophila melanogaster, eggs and larva, were studied. Purine and 2,6-diaminopurine both were very toxic to egg development. Adenine and 2,6-diaminopurine were moderately and equally toxic to larva development. Substitution on the 6-position of the purine ring was very effective in regulating metamorphosis of Drosophila.
D015075:2-Aminopurine / Q000031:analogs & derivatives / Q000494:pharmacology; D000225:Adenine / Q000494:pharmacology; D000818:Animals; D002606:Charcoal; D004331:Drosophila melanogaster / Q000254:growth & development*; D006147:Guanine / Q000494:pharmacology; D007814:Larva; D011687:Purines / Q000494:pharmacology*
D011687:Purines; D002606:Charcoal; D015075:2-Aminopurine; C007300:2,6-diaminopurine; D006147:Guanine; D000225:Adenine