[Effect of dopamine and met-enkephalin on the background and evoked spike activity of rat neostriatal neurons].
Extracellular recordings of 191 neostriatum neurons revealed the effects of ionophoretically applied dopamine, met-enkephalin and morphine on spontaneous and glutamate- and acetylcholine-evoked unit activity. Dopamine either depressed or enhanced the spontaneous and glutamate-evoked activities depending on the firing rate. Met-enkephalin depressed the spontaneous, glutamate- and acetylcholine evoked activities. These findings suggest that dopamine exerts a modulatory effect on glutamatergic synaptic neurotransmission in the rat neostriatum.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D004347:Drug Interactions; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology / Q000502:physiology; D018698:Glutamic Acid; D008297:Male; D009020:Morphine / Q000494:pharmacology; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects
D005971:Glutamates; D018698:Glutamic Acid; D004744:Enkephalin, Methionine; D009020:Morphine; D000109:Acetylcholine; D004298:Dopamine
Vliianie dofamina i met-énkefalina na fonovuiu i vyzvannuiu impul'snuiu aktivnost' neĭronov neostriatuma u krys.