title: beta 2-Microglobulin.
abstract: In the sixties, Ingemar Berggård discovered, isolated and characterized the low molecular weight protein beta 2-microglobulin. The relations of beta 2-microglobulin to the immune system have led to intensive research on this protein. The present work reviews the purification and characterization of human beta 2-microglobulin and animal homologues, the association of beta 2-microglobulin to other molecules, the functional studies with beta 2-microglobulin and antibodies against beta 2-microglobulin, and the evolutionary studies on beta 2-microglobulin.
mesh_terms: D000818:Animals; D001609:Beta-Globulins / Q000502:physiology*; D005075:Biological Evolution; D001826:Body Fluids / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003602:Cytotoxicity, Immunologic; D006168:Guinea Pigs; D006801:Humans; D007111:Immunity, Cellular; D007141:Immunoglobulin Fc Fragments / Q000235:genetics; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex; D011817:Rabbits; D051381:Rats; D014018:Tissue Distribution; D001613:beta 2-Microglobulin / Q000302:isolation & purification / Q000502:physiology*
chemical_list: D001609:Beta-Globulins; D007141:Immunoglobulin Fc Fragments; D001613:beta 2-Microglobulin