title: Irritation and staining by dithranol (anthralin) and related compounds: II. Structure-activity relationships among 10-meso-substituted acyl analogues.
abstract: Irritation and staining by dithranol and some 10-meso-substituted acyl analogues was studied with the chamber-testing technique in a series of 50 psoriasis patients. The test concentrations for dithranol, 10-acetyldithranol, 10-propionyldithranol and 10-butyryldithranol were 0.05 and 0.5%, for 10-valeryldithranol 5% and for 10-myristolydithranol 10%. As a rule, with increasing length of the carbon chain of the 10-acyl substituent (from 2C to 14C) the staining and irritative properties of the molecule decreased.
mesh_terms: D000873:Anthracenes / Q000031:analogs & derivatives*; D000875:Anthralin / Q000009:adverse effects / Q000031:analogs & derivatives*; D003875:Drug Eruptions / Q000209:etiology*; D004487:Edema / Q000139:chemically induced; D004890:Erythema / Q000139:chemically induced; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy; D012867:Skin / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000873:Anthracenes; D000875:Anthralin