Quantitated determination of proteins in perilymph in patients with acoustic neuromas.
Perilymph, cerebrospinal fluid (CSF) and plasma from 19 patients with acoustic neuromas were examined for albumin, alpha 2-macroglobulin and IgG. Patients with otosclerosis were used as controls. A highly significant increase of the tested proteins was found in perilymph from patients with acoustic neuromas. Determination of the tau-transferrin, which is a specific CNS protein, could neither be demonstrated in plasma nor in perilymph. This is in favour of the assumption that perilymph is plasma-derived and not concentrated CSF. Various causes for the high protein concentrations are discussed, and it is suggested that the increase is caused by a blockage of the neuroaxonal transport mechanisms.
D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007761:Labyrinthine Fluids / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000032:analysis*; D010498:Perilymph / Q000032:analysis*; D011506:Proteins / Q000032:analysis*; D014168:Transferrin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis; D016875:tau Proteins
D000418:Albumins; D007074:Immunoglobulin G; D011506:Proteins; D014168:Transferrin; D000511:alpha-Macroglobulins; D016875:tau Proteins