Bleomycin-induced structural chromosomal aberrations in spermatogonia and bone-marrow cells of mice.
The induction of structural chromosomal aberrations by bleomycin (BLM) was studied in bone-marrow cells and spermatogonia of the mouse at doses of 10, 20, 40 and 80 mg/kg. BLM induced genetically important reciprocal translocations in stem-cell spermatogonia as measured with the spermatocyte test, and the response of bone-marrow cells to BLM was not markedly different from that of spermatogonia.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D013093:Spermatogonia / Q000648:ultrastructure; D013997:Time Factors
D001761:Bleomycin