Ecotoxicology of phenylphosphonothioates.
The phenylphosphonothioate insecticides EPN and leptophos, and several analogs, were evaluated with respect to their delayed neurotoxic effects in hens and their environmental behavior in a terrestrial-aquatic model ecosystem. Acute toxicity to insects was highly correlated with sigma sigma of the substituted phenyl group (regression coefficient r = -0.91) while acute toxicity to mammals was slightly less well correlated (regression coefficient r = -0.71), and neurotoxicity was poorly correlated with sigma sigma (regression coefficient r = -0.35). Both EPN and leptophos were markedly more persistent and bioaccumulative in the model ecosystem than parathion. Desbromoleptophos, a contaminant and metabolite of leptophos, was seen to be a highly stable and persistent terminal residue of leptophos.
D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D002645:Chickens; D002800:Cholinesterase Inhibitors; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006793:Houseflies; D010773:Leptophos / Q000633:toxicity; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010243:Paralysis / Q000139:chemically induced; D010575:Pesticides / Q000633:toxicity; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester / Q000633:toxicity; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D004785:Environmental Pollutants; D009946:Organothiophosphorus Compounds; D010575:Pesticides; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; D010773:Leptophos