Attenuation by antidepressant drugs of alcohol intake in rats.
Ethanol preferring rats were selected and showed a constant voluntary intake of a 12% ethanol solution during 14 days (about 5 g/kg body weight daily). These alcohol preferring rats were daily IP injected during two weeks with different antidepressant drugs, according to their specificity of action: nomifensine (5 and 10 mg/kg) and maprotiline (2.5 and 5 mg/kg) (dopamine uptake inhibitors), desipramine and metapramine (5 and 10 mg/kg) (noradrenaline uptake inhibitors) clomipramine and doxepin (5 and 10 mg/kg) (serotonin uptake inhibitors). Only desipramine, 5 and 10 mg/kg, metapramine, 10 mg/kg, clomipramine, 5 and 10 mg/kg and doxepin, 10 mg/kg, were able to reduce significantly the ethanol intake. These drugs specifically inhibit noradrenaline or serotonin uptake. These data lead us to think that norepinephrine and/or serotonin, but not dopamine, are involved in the voluntary intake of alcohol.
D000428:Alcohol Drinking; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002997:Clomipramine / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D003984:Dibenzazepines / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D004316:Doxepin / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects; D008297:Male; D008376:Maprotiline / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000378:metabolism; D009627:Nomifensine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D000928:Antidepressive Agents; D003984:Dibenzazepines; D018377:Neurotransmitter Agents; D004316:Doxepin; D009627:Nomifensine; D008376:Maprotiline; C012677:metapramine; D012701:Serotonin; D002997:Clomipramine; D003891:Desipramine; D004298:Dopamine; D009638:Norepinephrine