Natural killer cell activity during treatment with fibroblast interferon.
Short- and long-term effects on natural cytotoxicity (NC) of i.v. administration of human fibroblast interferon (IFN--beta) was studied in patients with HBsAg positive chronic active hepatitis. Short-term kinetics demonstrated after a transient fall of NC a severalfold increase of NK activity after 24 hours. Long-term kinetics of NC revealed following features: The highest relative increase was seen during the initial phase of IFN--beta application. In all patients monitored so far the enhanced NK activity could be maintained during 2 to 4 weeks of therapy. Over a period of several weeks a gradual decrease of augmented NK activity was observed in spite of continued application of high doses of IFN--beta. These findings indicate that in-vivo administration of IFN--beta results in an augmentation of natural cytotoxicity in man. Prolonged treatment with IFN--beta seems to "exhaust" the NK cell system.
D000328:Adult; D005347:Fibroblasts / Q000378:metabolism*; D006505:Hepatitis / Q000188:drug therapy; D006801:Humans; D007372:Interferons / Q000096:biosynthesis* / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects*; D007700:Kinetics; D013997:Time Factors
D007372:Interferons