title: [Thiol-dependent cytolytic bacterial toxins: streptolysin O and prominent toxins].
abstract: Streptolysin O is the prototype of fifteen bacterial cytolytic protein toxins elaborated by gram-positive bacteria of species Streptococcus, Clostridium, Bacillus and Listeria. These toxins share a number of common properties: they are antigenically related as shown by cross-neutralization and immunoprecipitation; their cytolytic and other reducing agents; these toxins are inactivated by cholesterol and certain related sterols. This group of oxygen-labile cytolytic toxins has been named sulfyhdryl-activated toxins or thiol-activated cytolysins. The mechanism of action of these toxins is very likely identical or at least closely similar.
mesh_terms: D000936:Antigen-Antibody Complex; D001407:Bacillus / Q000276:immunology; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000276:immunology* / Q000302:isolation & purification; D003013:Clostridium / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes; D008087:Listeria / Q000276:immunology; D013291:Streptococcus / Q000276:immunology; D013301:Streptolysins / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000936:Antigen-Antibody Complex; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D000939:Epitopes; D013301:Streptolysins; C025964:streptolysin O
vernacular_title: Les toxines cytolytiques bactériennes thiol-dépendantes: streptolysine O et toxines apparentées.