Recovery of fast axonal transport and retinal protein synthesis in the rabbits after intraocular administration of vinblastine.
Orthograde fast axonal transport was almost completely blocked one day after the intraocular injection of 10-100 micrograms of vinblastine (VLB), then recovered gradually for up to 2 months. Recovery was not complete, however; there was a definite relationship between the dose of VLB administered and the degree of recovery of fast axonal transport. Retinal protein synthesis was reduced by intraocular VLB, but there was no relationship between the dose administered and the amount of reduction of protein synthesis. Cytotoxicity of VLB to the retina is less probable. The participation of retrograde axonal transport in the metabolism of cell bodies is discussed.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D007700:Kinetics; D007930:Leucine; D014176:Protein Biosynthesis / Q000187:drug effects*; D011817:Rabbits; D012160:Retina / Q000502:physiology*; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine; D007930:Leucine