Studies on Trypanosoma (nannomonas) congolense IV. Experimental immunization of mice against tsetse fly challenge.
Groups of mice were exposed to multiple bites by tsetse flies (Glossina morsitans morsitans) infected with a clone of Trypanosoma congolense spread over a periof of 8 days. The mice were subsequently treated with Berenil 10 days after the first fly bite as were uninfected control mice. The group of mice which received 12--15 infectious fly bites on two occasions, 21 days apart, were subsequently resistant to infection when re-challenged by flies infected with the same clone of T. congolense. These mice were also immune to challenge by flies infected with a different bloodstream variable antigen type derived from this same stock. The immunity was stock-specific and directed against the metacyclic forms of the parasite, but was short-lived.
D000818:Animals; D004133:Diminazene / Q000627:therapeutic use; D000939:Epitopes; D005260:Female; D007114:Immunization; D007299:Insect Bites and Stings / Q000469:parasitology*; D051379:Mice; D014345:Trypanosoma / Q000276:immunology*; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*; D014370:Tsetse Flies / Q000469:parasitology*
D000939:Epitopes; D004133:Diminazene