title: The viability of transplants of mesencephalic raphe nuclei in the IVth ventricle of the adult rat.
abstract: Mesencephalic raphe nuclei were transplanted via the cisterna magna near the locus coeruleus. The transplants were observed at different time intervals ranging from 24 h to 4 months. Microscopic observations revealed that from 3 weeks to 4 months the transplant developed with a well-defined neural organization. Radioautographic results showed that some of the neurons in the implant at 3 weeks captured and retained [3H] serotonin. These results indicate that the intact IVth ventricle seems to be a likely culturing floor for mesencephalic raphe nuclei.
mesh_terms: D000818:Animals; D001370:Axonal Transport; D001933:Brain Stem / Q000637:transplantation*; D002552:Cerebral Ventricles / Q000502:physiology*; D007700:Kinetics; D008636:Mesencephalon / Q000502:physiology / Q000637:transplantation*; D009474:Neurons / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D014316:Tritium
chemical_list: D014316:Tritium; D012701:Serotonin