title: Inhibition of dithranol inflammation by free-radical scavengers.
abstract: Dithranol (anthralin) inflammation of forearm skin was completely inhibited by various scavengers of free radicals of the oxygen species. It is concluded that dithranol inflammation is initiated by formation of free radicals; these may act through lipid peroxidation and production of inflammatory endoperoxides or by a more direct mechanism.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000873:Anthracenes / Q000009:adverse effects*; D000875:Anthralin / Q000008:administration & dosage / Q000009:adverse effects*; D002083:Butylated Hydroxyanisole / Q000627:therapeutic use; D004224:Diterpenes; D003875:Drug Eruptions / Q000209:etiology / Q000517:prevention & control*; D004890:Erythema / Q000139:chemically induced; D005260:Female; D005609:Free Radicals; D006801:Humans; D008297:Male; D008875:Middle Aged; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D000873:Anthracenes; D004224:Diterpenes; D005609:Free Radicals; D000084562:Retinyl Esters; D014801:Vitamin A; D014810:Vitamin E; C014794:retinol palmitate; D002083:Butylated Hydroxyanisole; C009166:retinol acetate; D000875:Anthralin