Synthesis, transport, and release of posterior pituitary hormones.
Vasopressin and oxytocin are made and released by neurons of the hypothalamo-neurohypophysial system. Pulse labeling these neurons with radioactive amino acid indicates that the two hormones and their respective neurophysin carrier proteins are synthesized as parts of separate precursor proteins. The precursors seem to be processed into smaller, biologically active molecules while they are being transported along the axon.
D000818:Animals; D001370:Axonal Transport; D003594:Cytoplasmic Granules / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008473:Median Eminence / Q000378:metabolism; D010121:Oxytocin / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000378:metabolism; D010909:Pituitary Hormones, Posterior / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D051381:Rats; D013495:Supraoptic Nucleus / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism*
D006023:Glycoproteins; D010909:Pituitary Hormones, Posterior; D011498:Protein Precursors; D014667:Vasopressins; D010121:Oxytocin