title: The lowest conductance state of the alamethicin pore.
abstract: High resolution experiments of the alamethicin pore demonstrate the existence of a further pore state at low conductance values. This lowest resolved conductance state is found at 19 pS in 1 M KCl at room temperature. The value differs from that of the next higher conductance state by a factor of 14--15 and is approx. 20% lower than the gramicidin A pore conductance. The lowest conductance state seems to be impermeable to Ca2+, Cl-, Tris-H+ and Hepes-, whereas the higher conductance states are not.
mesh_terms: D000408:Alamethicin; D000900:Anti-Bacterial Agents; D002021:Buffers; D002118:Calcium; D002712:Chlorides; D004553:Electric Conductivity; D006096:Gramicidin; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008051:Lipid Bilayers; D008433:Mathematics
chemical_list: D000900:Anti-Bacterial Agents; D002021:Buffers; D002712:Chlorides; D008051:Lipid Bilayers; D006096:Gramicidin; D000408:Alamethicin; D002118:Calcium