Cells infected with herpes simplex virus induce human monocyte-macrophages to produce interferon.
Human monocyte-macrophages (MO) produced interferon when incubated with human fibroblast, Vero cell, or rabbit kidney cell cultures infected with herpes simplex virus (HSV). Induction of MO interferon required a 12-hour incubation with the HSV-infected cultures. The interferon produced biologically resembled human leukocyte-derived rather than human fibroblasts-derived interferon.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D006561:Herpes Simplex / Q000276:immunology*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis* / Q000494:pharmacology; D008264:Macrophages / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism*; D011817:Rabbits; D011961:Receptors, Fc; D018139:Simplexvirus / Q000276:immunology
D000998:Antiviral Agents; D011961:Receptors, Fc; D007372:Interferons