The Pharmacology of the hypotensive action of N,N-dimethyl para-methoxyphenylethylamine in rats.
N,N-dimethyl para-methoxyphenylethylamine prevents hypertension and reverses existing high blood pressure in DOCA-saline treated rats. Indomethacin prevents its hypotensive effect, therefore the suggested mechanism is increase in prostaglandin(s) synthesis. The effect of the usual receptor antagonists on the hypotensive effect of the title compound can also be fitted into the framework of this hypothesis.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D011968:Receptors, Histamine / Q000187:drug effects; D014439:Tyramine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D011453:Prostaglandins; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D011968:Receptors, Histamine; C032141:N,N-dimethyl-4-methoxyphenylethylamine; D011433:Propranolol; D006220:Haloperidol; D014439:Tyramine