title: Partial ejaculatory incompetence: the therapeutic effect of midodrine, an orally active selective alpha-adrenoceptor agonist.
abstract: The syndrome of partial ejaculatory incompetence has been reviewed. 6 patients, diagnosed as suffering from partial ejaculatory incompetence, were studied. For each subject, large numbers of spermatozoa were present in the post-masturbation urine sample providing evidence of disturbed ejaculatory function. The effect of a potent alpha-adrenoceptor agonist (Midodrine) was evaluated in these patients by means of a double-blind crossover study. Active treatment resulted in a significant increase in intensity of orgasmic sensation, and in a statistically significant improvement in ejaculatory function.
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004341:Drug Evaluation; D004542:Ejaculation / Q000187:drug effects*; D004983:Ethanolamines / Q000627:therapeutic use*; D005832:Genital Diseases, Male / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008879:Midodrine / Q000627:therapeutic use*; D013076:Sperm Count
chemical_list: D004983:Ethanolamines; D008879:Midodrine