Inhibition of lymphoma hybrids by human interferon.
A set of stable mouse-human hybrids was constructed from the neoplastic lymphocytes from a patient with nodular lymphoma and from another with chronic lymphocytic leukaemia. Both patients had shown a clinical response to human leucocyte interferon. The same interferon preparation inhibited the growth rate of 14 out of 17 established hybrid cell lines. This system provides evidence of a direct growth inhibitory effect of interferon on neoplastic B lymphocytes. Such a system could be used to predict the sensitivity of a patient's tumour before therapy.
D000368:Aged; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D006801:Humans; D006822:Hybrid Cells / Q000187:drug effects*; D007372:Interferons / Q000494:pharmacology* / Q000627:therapeutic use; D007945:Leukemia, Lymphoid / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D008297:Male; D051379:Mice; D008875:Middle Aged; D013045:Species Specificity
D007372:Interferons