Substance P and neurotensin in the control of gastrointestinal function.
Our experimental data show that neurotensin or a metabolite satisfies the rigid physiological criteria that should be met before a substance is classified as a true hormone with endocrine function. The gastrointestinal actions are produced by very small concentrations; the release into the blood is produced by a physiological stimulus (ingestion of food, especially fat); and the plasma concentrations of NTLI following the ingestion of food are comparable to those obtained by giving exogenous neurotensin at doses which produce effects in the gastrointestinal tract.
D000818:Animals; D004068:Digestive System Physiological Phenomena; D005753:Gastric Mucosa / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007422:Intestines / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009496:Neurotensin / Q000494:pharmacology / Q000502:physiology*; D013373:Substance P / Q000494:pharmacology / Q000502:physiology*
D013373:Substance P; D009496:Neurotensin