New steroids with antiprogestational and antiglucocorticoid activities.
A number of 11-substituted 19-norsteroids with inverse configuration at C-13 were synthesized. 11 beta-Aryl compounds in this series were found to possess antiprogestational and antiglucocorticoid activities.
D000022:Abortion, Spontaneous / Q000139:chemically induced; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000037:antagonists & inhibitors*; D007536:Isomerism; D010777:Photochemistry; D011247:Pregnancy; D011372:Progestins / Q000037:antagonists & inhibitors*; D051381:Rats; D013256:Steroids / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D014444:Tyrosine Transaminase / Q000096:biosynthesis
D005938:Glucocorticoids; D011372:Progestins; D013256:Steroids; D014444:Tyrosine Transaminase