Inhibition by 2',3'-dideoxythymidine of retroviral infection of mouse and human cells.
Infection of mouse and human cells with type C murine leukemia/sarcoma viruses was inhibited by the nucleoside analogue 2',3'-dideoxythymidine (ddT). Cell growth and virus synthesis by previously infected cells were not affected by the analogue. Infection of rat cells with murine retroviruses was not inhibited by ddT.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002472:Cell Transformation, Viral / Q000187:drug effects*; D002478:Cells, Cultured; D015224:Dideoxynucleosides; D006801:Humans; D007708:Kirsten murine sarcoma virus / Q000187:drug effects; D051379:Mice; D051381:Rats; D012190:Retroviridae / Q000187:drug effects*; D018894:Reverse Transcriptase Inhibitors; D013936:Thymidine / Q000031:analogs & derivatives* / Q000494:pharmacology
D015224:Dideoxynucleosides; D018894:Reverse Transcriptase Inhibitors; C019336:2',3'-dideoxythymidine; D013936:Thymidine