Oral disodium cromoglycate in mastocytosis.
Oral disodium cromoglycate was found useful for the treatment of gastrointestinal manifestations of mastocytosis in 2 patients with systemic disease. The urinary excretion of histamine in these 2 patients decreased following treatment. Oral disodium cromoglycate had no effect on cutaneous symptoms, either in these 2 patients nor in 2 other patients with urticaria pigmentosa without signs of systemic mastocytosis. In the latter 2 patients the urinary excretion of histamine was unaffected. Treatment was given for 4 to 6 weeks and the dose of disodium cromoglycate was 100 mg four times daily in the 3 adult patients and 100 mg three times daily in the fourth patient, an 8-year-old boy.
D000284:Administration, Oral; D000328:Adult; D002648:Child; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D006632:Histamine / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D014582:Urticaria Pigmentosa / Q000188:drug therapy* / Q000652:urine
D006632:Histamine; D004205:Cromolyn Sodium