Studies on fibronectin in the skin: VI. Intra-epidermal depositions in vulgar psoriasis, lupus erythematosus, bullous pemphigoid and dermatitis herpetiformis.
The fibronectins are a group of glycoproteins present in plasma and cellular tissues. They are produced by fibroblasts and endothelial cells, and are of importance in cellular adhesion and spreading. Fibronectin has a special affinity to fibrous proteins such as collagen and elastin, and is abundantly present in normal skin in the dermo-epidermal junction area, dermis, and subcutis. Fibronectin is not found in the epidermis. In a number of diseases fibronectin can be demonstrated in the epidermis of lesional skin, with or without affection of the dermo-epidermal junction area. Such changes are found in psoriasis vulgaris, lupus erythematosus, bullous pemphigoid and dermatitis herpetiformis, and represent the exoserosis of plasma and/or transepidermal elimination of degenerated tissue structure with fibronectin from the dermo-epidermal junction and the papillary dermis.
D003874:Dermatitis Herpetiformis / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism; D008297:Male; D010391:Pemphigoid, Bullous / Q000378:metabolism; D011565:Psoriasis / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism*
D005353:Fibronectins