title: [Multiple sclerosis and the histocompatibility system].
abstract: Examination of the histocompatibility antigens carried out in 62 patients of the Russian nationality suffering from disseminated sclerosis showed that the HLA-B7 antigen was encountered in them more frequently than in healthy people. The distribution of the A2 and A3 antigens of the HLA system was different depending on the character of the disease course, the A2 antigen was prevalent in a relatively benign, remitting process, while prevalence of the A3 antigen was characteristic for rapidly progressing processes that led to grave affections of the nervous system. In the patients' families two haplotypes, i. e. A2B7 and A3B7 were found to be prevalent.
mesh_terms: D000293:Adolescent; D000328:Adult; D000939:Epitopes / Q000032:analysis; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D012075:Remission, Spontaneous; D012426:Russia
chemical_list: D000939:Epitopes; D006680:HLA Antigens
vernacular_title: Rasseiannyĭ skleroz i sistema gistosovmestimosti (HLA).