Effects of intracerebroventricular administration of tonin on water intake and blood pressure in the rat.
Intracerebroventricular administration of tonin, an enzyme which releases angiotensin II directly from various substrates, stimulated water intake and increased blood pressure in the rat. These responses were abolished by the simultaneous administration of an angiotensin II antagonist and were unaffected by the nonapeptide inhibitor of angiotensin I-converting enzyme. These findings suggest that tonin may participate in the physiological regulation of water balance and blood pressure through local and direct generation of angiotensin II in the central nervous system.
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D007276:Injections, Intraventricular; D009842:Oligopeptides / Q000494:pharmacology; D007703:Peptidyl-Dipeptidase A / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012504:Saralasin / Q000494:pharmacology; D013722:Teprotide
D009842:Oligopeptides; D000804:Angiotensin II; D013722:Teprotide; D007703:Peptidyl-Dipeptidase A; D012504:Saralasin