Strain dependence of the antiproliferative action of interferon on murine erythroid precursors.
Electrophoretically pure mouse interferon inhibits erythropoietin-dependent proliferation of committed erythroid precursors (CFU-E) obtained either from adult mouse bone marrow or from 14-day fetal mouse livers. The degree of inhibition is significantly influenced by the genotype of the cell donor; about ten times as much interferon is required to inhibit proliferation of CFU-E from C57BL/6 than is needed for comparable inhibition of CFU-E from BALB/c or Swiss mice. These strain-dependent results point to the existence of genes that influence the degree of the inhibitory effect of interferon on cell multiplication.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D004622:Embryo, Mammalian; D004920:Erythropoiesis / Q000187:drug effects*; D005260:Female; D007372:Interferons / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013045:Species Specificity
D007372:Interferons