F-cell production in sickle cell anemia: regulation by genes linked to beta-hemoglobin locus.
Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the beta S-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.
D000755:Anemia, Sickle Cell / Q000235:genetics*; D044383:Black People; D004920:Erythropoiesis; D005260:Female; D005319:Fetal Hemoglobin / Q000235:genetics*; D005786:Gene Expression Regulation; D005787:Gene Frequency; D008040:Genetic Linkage; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012156:Reticulocytes / Q000378:metabolism*; D012529:Saudi Arabia; D012805:Sickle Cell Trait / Q000235:genetics; D014481:United States; D001741:Black or African American
D006451:Hemoglobin, Sickle; D005319:Fetal Hemoglobin