Persistence and variation of Mangosta street rabies virus antigens during adaptation into mice.
A Mangosta street rabies virus strain antigen not shared by the challenge virus standard (CVS) was identified by counterimmunoelectrophoresis. This strain antigen persisted following nine mouse passages of the virus, during which the CVS strain antigen was not acquired. These observations suggest that the antigen composition of the two virus strains is different. Antigenic differences during the course of adaptation of Mangosta virus were also revealed by crossed serum neutralization tests. The findings are discussed in terms of the occurrence of variations in the number and localizaion of antigen sites in the virus and of the possible existence of antigenic competition by non-infective viral antigens in serum neutralization tests for rabies.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D001921:Brain / Q000382:microbiology; D003378:Counterimmunoelectrophoresis; D003429:Cross Reactions; D000939:Epitopes; D008297:Male; D051379:Mice; D009500:Neutralization Tests; D011817:Rabbits; D011820:Rabies virus / Q000254:growth & development / Q000276:immunology*; D014776:Virus Cultivation; D014779:Virus Replication
D000956:Antigens, Viral; D000939:Epitopes