[Identification and characteristics of steroid hormone receptor binding properties in the nuclear fraction of human prostatic adenoma].
Steroid receptors in adenoma nuclear fraction of the human prostate were studied. Androgen and progestin receptors were revealed in 0.4 KCl nuclear extracts. The measured association constant values were 6.05 +/- 1.45 X 10(9) M-1 and 2.08 +/- 0.37 X 10(9) M-1 for 5 alpha-dihydrotestosterone and progesterone, respectively. Only 5 alpha-dihydrotestosterone and testosterone competed markedly with 3H-5 alpha-dihydrotestosterone, hormonal specificity of 3H-progesterone binding affinity being less pronounced. Specific estradiol binding being found in several adenomas was very low. Glucocorticoid receptors were not detected.
D002467:Cell Nucleus / Q000378:metabolism*; D003907:Dexamethasone / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D011374:Progesterone / Q000378:metabolism; D011397:Promegestone / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000473:pathology*; D011987:Receptors, Steroid / Q000378:metabolism*
D011987:Receptors, Steroid; D013196:Dihydrotestosterone; D011374:Progesterone; D004958:Estradiol; D003907:Dexamethasone; D011397:Promegestone; D006854:Hydrocortisone
Identifikatsiia i kharakteristika sviazyvaiushchikh svoĭstv retseptorov steroidnykh gormonov v iadernoĭ fraktsii adenom predstatel'noĭ zhelezy cheloveka.