Systemic retinoids in dermatology.
Orally administered retinoids are synthetic derivatives of vitamin A. This new group of drugs (not yet available for general use in the United States) has been effective in experimental trials for treatment of a wide range of skin diseases. The current status of two of these drugs, isotretinoin (13-cis-retinoic acid) and etretinate (Ro 10-9359), is herein reviewed.
D000152:Acne Vulgaris / Q000188:drug therapy; D000284:Administration, Oral; D002648:Child; D002986:Clinical Trials as Topic; D005148:Facial Dermatoses / Q000139:chemically induced; D005260:Female; D006801:Humans; D007536:Isomerism; D015474:Isotretinoin; D007633:Keratins / Q000096:biosynthesis; D007634:Keratitis / Q000188:drug therapy; D009369:Neoplasms / Q000517:prevention & control; D011565:Psoriasis / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*; D014987:Xerostomia / Q000139:chemically induced
D014212:Tretinoin; D007633:Keratins; D015474:Isotretinoin