Split of HLA-D into two regions alpha and beta by a recombination between HLA-D and GLO. I. Study in a family and primed lymphocyte typing for determinants coded by the beta region.
In a family with a paternal recombinant child between HLA-D/Dr and GLO, PLT have been raised between HLA-A-B-C-D-DR and Bf identical sibs. Since these sibs differ only within a region (beta) between HLA-D/DR and GLO and the centromere, these PLTs allow the typing of two new determinants differing from HLA-D/DR, possibly alleles at a new locus mapping in a region outside HLA-D/DR. A difference limited to this beta region can induce a weak primary and a strong secondary MLR.
D002874:Chromosome Mapping; D011415:Complement Factor B / Q000235:genetics; D000939:Epitopes; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011995:Recombination, Genetic; D013869:Thiolester Hydrolases / Q000276:immunology*; D000099301:Hydroxyacylglutathione Hydrolase
D011415:Complement Factor B; D000939:Epitopes; D006680:HLA Antigens; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase