title: Observations on the "cytoskeleton" of human platelets.
abstract: Structural study of rapidly lysed platelets supports the view that that shape change involves a change in state of the microfilaments which contain actin. The microtubule "bundle" appears to be a continuous coil. Proteolysis of a high molecular weight band is observed in platelets which can no longer form filopodia after suppression by local anesthetics.
mesh_terms: D001792:Blood Platelets / Q000166:cytology*; D003599:Cytoskeleton / Q000502:physiology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008870:Microtubules / Q000502:physiology*; D008970:Molecular Weight; D009218:Myosins; D013194:Staining and Labeling; D013748:Tetracaine / Q000494:pharmacology; D013997:Time Factors
chemical_list: D013748:Tetracaine; D009218:Myosins; D004121:Dimethyl Sulfoxide