title: [Aprotinin-ACD-blood: I. Experimental studies on the effect of aprotinin on the plasmatic and thrombocytic coagulation (author's transl)].
abstract: Aprotinin interrupts the spontaneous formation of microaggregates in stored blood. The analysis of the aprotinin-induced effects on the plasmatic and thrombocytic clotting systems showed a correlation between concentration and inhibitory effects of aprotinin on clotting factor VIII, IX, XI, XII as well as on the enzyme-induced second phase aggregation of the platelets. The effect of aprotinin on inhibition of platelet aggregation is probably due to binding of enzymes located in the membrane. The membrane stabilizing effect of aprotinin is discussed. Also in different experimental models using enzyme kinetic designs under maximal aprotinin inhibition a normalization of platelet functions could be immediately reached under transfusion analogous conditions. It is therefore, assumed that transfusion of aprotinin-ACD-Blood does not alter the coagulation mechanism of the patient.
mesh_terms: D007611:Aprotinin / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology; D001793:Blood Preservation / Q000379:methods*; D002462:Cell Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D001779:Blood Coagulation Factors; D007611:Aprotinin
vernacular_title: Aprotinin-ACD-Blut. I. Experimentelle Untersuchungen über den Einfluss von Aprotinin auf die plasmatische und thrombozytäre Gerinnung.