Benzodiazepines and GABAergic regulation of nigrostriatal neurons: lack of tolerance.
Decreases of 40 to 50% in striatal dopamine release by diazepam in doses above 5 mg/kg were elicited. Similar actions were observed with clonazepam and nitrazepam. No tolerance to these actions was evident after 3 weeks of chronic treatment. These data are consistent with a potent inhibitory GABAergic regulation of nigrostriatal dopaminergic neurons.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002998:Clonazepam / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D009567:Nitrazepam / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D002998:Clonazepam; D009567:Nitrazepam; D003975:Diazepam