Lipoprotein immunogenetics in primates. I. Two serum beta-lipoprotein allotypes (Lmb1 and Lmb11) in rhesus monkeys and the LP-B immunological relationship with other primates.
Immunogenetic investigations on two serum beta-lipoprotein allotypes of rhesus monkeys (Macaca mulatta) are reported. The allotypes, designated Lmb1 and Lmb11, are associated with the main lipoprotein family, LP-B or beta-lipoprotein, expressed on independent beta-molecules, and classify rhesus monkeys into three phenotypes: Lmb1, Lmb11, and Lmb1,11. Genetic and molecular studies indicate that the allotypes are encoded by two codominant autosomal allelic genes, Lmb1 and Lmb11. Anti-Lmb1 cross-reacts with the sera of two other macaque species, whereas anti-Lmb11 with sera of all Old World monkeys. Heteroimmune sera, antihuman apo-B and antirhesus LP-B, showed high but diversified degrees of cross reactivity with other primates.
D000818:Animals; D002520:Cercopithecidae / Q000235:genetics; D003429:Cross Reactions; D005799:Genes, Dominant; D005838:Genotype; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D008077:Lipoproteins, LDL / Q000097:blood / Q000235:genetics*; D008253:Macaca mulatta / Q000097:blood / Q000235:genetics*; D011323:Primates / Q000235:genetics*
D008077:Lipoproteins, LDL