[Nervous system tumour proteins. G.F.A. and hyaluronectin (author's transl)].
G.F.A. (gliofibrillary acid protein) and hyaluronectin studied here are two antigens defined by the heteroantibodies which appear in the serum of the immunised animal. G.F.A. is associated with gliofilaments and is considered as an astrocyte marker, either normal or tumoral. Hyaluronectin, is found in the Ranvier nodes and at the periphery of neurones. It is not specific to the nervous system. It is found in all tissues and tumors, and in particular marks the intercellular spaces of gliomas, where it is associated with hyaluronic acid for which it has a great affinity. Serum estimation of these Proteins is being undertaken with the view to a clinical application.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis*; D005904:Glial Fibrillary Acidic Protein; D006801:Humans; D018960:Hyaluronan Receptors; D009363:Neoplasm Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009423:Nervous System Neoplasms / Q000032:analysis* / Q000276:immunology; D011817:Rabbits
D000951:Antigens, Neoplasm; D002352:Carrier Proteins; D005904:Glial Fibrillary Acidic Protein; D018960:Hyaluronan Receptors; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins
Les proteéines des tumeurs du système nerveux. G.F.A. et hyaluronectine.