Non-blastic meningeal leukemia during the myelofibrotic phase of chronic myeloid leukemia.
Myeloblastic involvement of the central nervous system has been noted in the course of chronic myeloid leukemia in the blastic phase; meningeal leukemia in the chronic phase of CML is almost unknown. We report on a case of CML in which meningeal infiltration by cells of the granulocytes series in all stage of cellular maturation developed 15 years after initial diagnosis and seven months after a myelofibrotic transformation of the systemic disease.
D000328:Adult; D002555:Cerebrospinal Fluid / Q000166:cytology*; D002904:Chromosomes, Human, 21-22 and Y; D006412:Hematopoietic Stem Cells; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology*; D055728:Primary Myelofibrosis / Q000209:etiology