A permeability-enhancing factor produced by tumor. The genesis of malignant effusions.
The intra-articular injection of ascites fluid or of extracts derived from malignant tumors was shown to induce exudative joint lesions. The intra-articular injection of normal plasma did not have this effect. It is suggested that tumor secretes a permeability-enhancing agent. This substance promotes the extravasation of humoral or cellular elements into the joint spaces. A similar mechanism may underlie the development of pulmonary arthropathy or the formation of malignant effusions.
D000818:Animals; D001168:Arthritis / Q000209:etiology* / Q000473:pathology; D002199:Capillary Permeability; D007111:Immunity, Cellular; D007719:Knee Joint; D008175:Lung Neoplasms / Q000378:metabolism; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D000511:alpha-Macroglobulins / Q000378:metabolism
D000511:alpha-Macroglobulins; D010447:Peptide Hydrolases