Superfractionated irradiation combined with low doses of bleomycin in the treatment of oral carcinoma.
Seven patients with advanced oral carcinoma have been given 1 Gy per irradiation up to total dose 74 to 81 Gy. Bleomycin was given intramuscularly before irradiation. The therapeutic ratio of the proposed scheme was good. The early reactions were severe but were managed by a split course technique. No late complication occurred. All patients were tumour-free 18 to 54 months after treatment. A relapse occurred only in one case. The results are not conclusive, but bearing in mind that the results in advanced oral carcinoma are poor they suggest that the proposed treatment regime may be promising.
D000368:Aged; D001761:Bleomycin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011879:Radiotherapy Dosage
D001761:Bleomycin