Proteinuria following nephroangiography. IX. Chemical and morphological analysis in dogs.
Following unilateral selective nephroangiography with diatrizoate, changes in urinary concentrations of prealbumin, albumin, IgG and alpha 2-macroglobulin were analysed in 8 dogs. All reacted with increased proteinuria. The median increase of urinary albumin concentration was 1,300 times (range 27-3 500). The proteinuria was caused mainly by increased glomerular permeability exhibiting some molecular size selectivity in filtration of the proteins measured. Light and electron microscopy did not reveal any glomerular on tubular abnormalities which could be attributed to effects of the angiography. It is suggested that the increased glomerular permeability to proteins might be an effect of disturbance of the electrical hindrance in the glomerular capillary wall.
D000419:Albuminuria / Q000139:chemically induced; D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007074:Immunoglobulin G / Q000652:urine; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D011228:Prealbumin / Q000652:urine; D011507:Proteinuria / Q000139:chemically induced*; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging*; D000511:alpha-Macroglobulins / Q000652:urine
D003287:Contrast Media; D007074:Immunoglobulin G; D011228:Prealbumin; D000511:alpha-Macroglobulins; D003974:Diatrizoate Meglumine