Sensory and motor functions of spinal cord substance P.
Low doses of D-Pro2-D-Phe7-D-Trp9-substance P, as specific substance P antagonist, depressed the scratching and biting behaviors elicited by intrathecal injections of substance P, and cutaneous application of algesic substances. Higher antagonist doses caused hindlimb paralysis. This suggests that substance P is a neurotransmitter for primary nociceptor afferents and may also have an important function in motor control.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000503:physiopathology*; D011956:Receptors, Cell Surface / Q000187:drug effects; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012867:Skin / Q000187:drug effects; D013116:Spinal Cord / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*
D011956:Receptors, Cell Surface; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; C033149:substance P, Trp(9)-; D013373:Substance P; D002211:Capsaicin