[Identification of a new antigenic variant of simian adenovirus (SV30N)].
A new variant of simian adenovirus SV30-N is described. The variant is antigenically close to SV30 virus in the neutralization test but has some antigenic relationship to SA7 virus. The properties of SV30-N virus were retained after 5 clonings by the plaque method, after passage and cloning of the virus treated with immune sera to SV30 or SA7. The heteroduplex analysis showed DNA of the virus under study to be by 80% and 40% homologous to SV30 DNA and SA7 DNA, respectively, whereas no heteroduplex molecules between SV30 and SA7 DNA were found. By the set of polypeptides the antigenic variant SV30-N is close to SV30 but differs from SV30 and, particularly from SA7. Unlike SV30 and SA7 viruses, the SV30-N virus showed no oncogenic activity for hamsters.
D000256:Adenoviridae / Q000276:immunology*; D000261:Adenoviruses, Simian / Q000032:analysis / Q000276:immunology* / Q000302:isolation & purification; D000956:Antigens, Viral / Q000032:analysis*; D000939:Epitopes / Q000032:analysis; D009500:Neutralization Tests; D009692:Nucleic Acid Heteroduplexes / Q000032:analysis; D012703:Serotyping; D013045:Species Specificity; D014764:Viral Proteins / Q000032:analysis
D000956:Antigens, Viral; D000939:Epitopes; D009692:Nucleic Acid Heteroduplexes; D014764:Viral Proteins
Identifikatsiia novogo antigennogo varianta adenovirusa obez'ian (SV30N).