Interactions between sodium diethyl-dithiocarbamate and lysozyme during the immune response to a hapten-carrier complex.
The effects of lysozyme and sodium diethyl-dithiocarbamate (DTC) were studied on antibody synthesis induced by immunization with a hapten-carrier complex. The immunomodulating effects of lysozyme could be partially reversed by DTC, a sulphur derivative which has been previously shown to modulate the immune response, probably at the macrophage level. The mechanisms whereby lysozyme and DTC modulated the immune response are discussed.
D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002352:Carrier Proteins / Q000276:immunology; D004140:Dinitrophenols; D004050:Ditiocarb / Q000494:pharmacology*; D004347:Drug Interactions; D006168:Guinea Pigs; D006241:Haptens; D009113:Muramidase / Q000494:pharmacology*; D012709:Serum Albumin; D013859:Thiocarbamates / Q000494:pharmacology*; D005719:gamma-Globulins
D002352:Carrier Proteins; D004140:Dinitrophenols; D006241:Haptens; D012709:Serum Albumin; D013859:Thiocarbamates; D005719:gamma-Globulins; D004050:Ditiocarb; D009113:Muramidase