title: Small-volume electrochemical detector for microcolumn liquid chromatography.
abstract: A submicroliter electrochemical detector for liquid chromatography has been designed, using pressure-annealed pyrolytic graphite technology. The analytical performance of this detector was studied in connection with a reversed-phase packed microcapillary column at very low flow-rates. Although the miniaturized version of the electrochemical detector is less sensitive, a direct analysis of a number of urinary metabolites in 0.1--1.0 microliters samples is feasible.
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods; D004563:Electrochemistry; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008297:Male; D008433:Mathematics; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D008832:Microchemistry / Q000379:methods; D010648:Phenylacetates / Q000652:urine; D014364:Tryptophan / Q000652:urine*; D014443:Tyrosine / Q000652:urine*; D014641:Vanillic Acid / Q000652:urine
chemical_list: D010648:Phenylacetates; C008070:4-hydroxyphenylacetic acid; D014443:Tyrosine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D014641:Vanillic Acid; D006719:Homovanillic Acid