A novel rearrangement of the human beta-like globin gene cluster.
The first example of a duplication involving the human beta-like globin genes has been characterised in DNA from a native of Vanuatu. Restriction endonuclease mapping has shown that a 5 kb insert of DNA in the gamma-delta-beta gene cluster is due to duplication of the Ggamma-globin gene and results in a new rearrangement 5'-epsilon-Ggamma-Ggamma-Agamma-delta-beta-3'.
D000328:Adult; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D005796:Genes; D005914:Globins / Q000235:genetics*; D006443:Hemoglobin A2 / Q000032:analysis; D006801:Humans; D008297:Male; D012091:Repetitive Sequences, Nucleic Acid; D013789:Thalassemia / Q000097:blood / Q000235:genetics; D009514:Vanuatu
D005914:Globins; D004247:DNA; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin; D004262:DNA Restriction Enzymes