title: [Molecular-genetic basis of regulation of the synthesis of individual types of hemoglobin].
abstract: The data on the control of ontogenetic hemoglobin type synthesis were analyzed in normal and pathological human and animal organisms. The assumption is made that such control depends on the level of erythroid cell differentiation and erythropoetic factors activity. The latters act as a trigger in switching of qualitative hemoglobin production.
mesh_terms: D000755:Anemia, Sickle Cell / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002454:Cell Differentiation; D055598:Chemical Phenomena; D002621:Chemistry; D002874:Chromosome Mapping; D006224:Cricetinae; D004285:Dogs; D005319:Fetal Hemoglobin / Q000096:biosynthesis; D005786:Gene Expression Regulation; D005796:Genes; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006454:Hemoglobins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D051379:Mice; D009154:Mutation; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013789:Thalassemia / Q000235:genetics / Q000378:metabolism
chemical_list: D006454:Hemoglobins; D012333:RNA, Messenger; D005319:Fetal Hemoglobin
vernacular_title: Molekuliarno-geneticheskie osnovy reguliatsii sinteza otdel'nykh tipov gemoglobina.