Studies of the MHC-linked "CT" alloantigenic system in rats. II. Evidence for more than one locus and several different determinants.
Previous studies have defined a novel, MHC-linked alloantigenic system in the rat (CT) detectable with cytotoxic T cells (CTL) generated by alloimmunization and restimulation using strain combinations thought to be RT1-compatible, for instance, Lewis and Fischer 344. CTLs generated in this way are able to lyse targets from a variety of different strains without any evidence of MHC-restricted interactions, and yet these CT determinants possess properties unlike conventional class I and class II MHC gene products. The present studies employ cold target competition assays to derive a minimal estimate of the number of different CT determinants detected with Lewis anti-Fischer 344 CTLs, the number of loci involved in their expression, and their strain distribution. The results indicate that Lewis anti-Fischer CTLs define at least four different determinants encoded by at least two different loci.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D000939:Epitopes / Q000235:genetics*; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D007519:Isoantigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D008297:Male; D010641:Phenotype; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D000939:Epitopes; D007519:Isoantigens