[Physiological role of alpha-fetoprotein. Effect of the injection of purified AFP on the ovarian activity of the adult female rat].
Alpha-fetoprotein injected in normal adult female Rats produced a decrease in ovarian activity. The histological study of the ovaries showed that the number of maturing follicles as well as the number of corpora lutea were lowered in AFP-treated Rats, but not in albumin-treated control animals. The serum level of progesterone was also largely decreased by AFP injections. A possible role of AFP in the regulation of the ovarian activity during pregnancy and post natal sexual development is proposed.
D000818:Animals; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D051381:Rats; D000509:alpha-Fetoproteins / Q000494:pharmacology / Q000502:physiology*
D000509:alpha-Fetoproteins; D011374:Progesterone
Rôle physiologique de l'alpha-faetoprotéine (AFP). Effet d'injection d'AFP purifiée sur l'activité ovarienne du Rat femelle adulte.