Role of some biogenic amines in the pathomechanism of glomerulonephritis. II. Adrenaline, noradrenaline and serotonin in acute serum sickness in rabbits.
In acute serum sickness induced with one intravenous dose of bovine serum albumin (BSA) in 40 rabbits the patterns of excretion of adrenaline (A), noradrenaline (NA), serotonin (5HT) and 5-hydroxyindole-acetic acid (5HIAA) were studied in 24-hour urine, and the 5HT level was determined at intervals of three days. The urinary levels of biogenic amines were determined daily. Some rabbits immunized with BSA received also additionally 5HT, reserpine or parachlorphenylalanine (PCPA). Administration of BSA to rabbits caused a significant increase in the excretion of A and NA and a less evident increase in 5HT level in the blood. The greatest correlation with the course of the immune reaction was shown by the increase in NA excretion observed on the 2nd and 3rd days after BSA administration, and then between the 5th and the 12th days of the experiment. Daily subcutaneous injections of 5HT during 15 days caused a significant rise of its level in the blood and urine, and an increase of 5HIAA excretion. After reserpine or PCPA administration a significant decrease of the levels of all these amines was observed. Taking into account the results of histological examination of the kidneys, that is intensification of the inflammatory changes after 5HT administration and evident inhibition of the inflammatory process after administration of reserpine and PCPA it must be accepted that the studied amines have an important role in the pathomechanism of glomerulonephritis in acute serum sickness.
D000208:Acute Disease; D000818:Animals; D004837:Epinephrine / Q000652:urine*; D010134:Fenclonine / Q000494:pharmacology; D005921:Glomerulonephritis / Q000139:chemically induced / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D009638:Norepinephrine / Q000652:urine*; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism* / Q000494:pharmacology; D012710:Serum Albumin, Bovine
D012710:Serum Albumin, Bovine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D012110:Reserpine; D010134:Fenclonine; D009638:Norepinephrine; D004837:Epinephrine