Characteristics of the interferon system of an embryonal carcinomal cell are recessive in intraspecific somatic cell hybrids.
We have obtained hybrids of PCC4-aza 1, a mouse embryonal carcinoma stem cell line, and two different thymidine kinase deficient mouse cell lines. We have examined the ability of the parental and hybrid cells to produce interferon after infection with the Newcastle Disease virus and to enter the antiviral state when treated with mouse interferon. The interferon system of PCC4-aza 1 is inactive; this characteristic is recessive in the hybrids obtained.
D002454:Cell Differentiation; D002460:Cell Line; D002874:Chromosome Mapping; D005808:Genes, Recessive; D006822:Hybrid Cells / Q000378:metabolism*; D007372:Interferons / Q000096:biosynthesis* / Q000235:genetics; D007621:Karyotyping; D013724:Teratoma / Q000378:metabolism*
D007372:Interferons