Production of interferon in human diploid cells at different population doubling levels.
Interferon (IFN) yield after superinduction declined gradually by in vitro senescence of the cells, while it remained unchanged in IFN-pretreated cells. IFN yield after stimulation with Newcastle disease virus remained unchanged by in vitro senescence.
D002460:Cell Line; D002470:Cell Survival; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis* / Q000494:pharmacology; D009522:Newcastle disease virus; D011070:Poly I-C / Q000494:pharmacology
D007372:Interferons; D011070:Poly I-C