Seasonal variation of IgE antibody specific for ragweed antigen E (IgE-a-AgE) from the basophil surface in patients with ragweed pollenosis.
Seasonal elevation in total serum IgE and IgE antibody specific for antigen E (IgE-a-AgE) are well recognized in patients with ragweed pollenosis. We found that the ratio of specific IgE-a-AgE to total IgE in plasma was the only measure predictive of the number of specific IgE-a-AgE molecules per basophil. Although both total and specific IgE rose with season, the ratio did not change, the number of IgE-a-AgE molecules per basophil did not change, and histamine release in response to AgE did not increase.
D000918:Antibody Specificity; D000941:Antigens; D001491:Basophils / Q000276:immunology; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007958:Leukocyte Count; D011058:Pollen; D011947:Receptors, Antigen, B-Cell; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D012621:Seasons
D000941:Antigens; D011947:Receptors, Antigen, B-Cell; D007073:Immunoglobulin E