title: Inhibition of axon reflex vasodilatation by topically applied capsaicin.
abstract: Topical application of capsaicin to human skin produced an initial burning erythematous reaction which diminished over 24 hr leaving the skin unresponsive to histamine-induced axon reflex vasodilatation without altering sensitivity to pain, touch and temperature. Depletion of substance P from local sensory nerve terminals is suggested as a possible explanation for this capsaicin effect.
mesh_terms: D000293:Adolescent; D000328:Adult; D001369:Axons / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D009433:Neural Inhibition; D012018:Reflex / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D013373:Substance P / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D005231:Fatty Acids, Unsaturated; D013373:Substance P; D006632:Histamine; D002211:Capsaicin