Hydromorphone detected in bile following hydrocodone ingestion.
Two similar cases are reported here in which Tussionex, a preparation containing hydrocodone and phenyltoloxamine, caused or contributed to death. Toxicological analyses revealed a high concentration ratio of hydromorphone to hydrocodone in the bile in both cases. It is postulated that the finding of hydromorphone is due to the metabolism of hydrocodone.
D000328:Adult; D001646:Bile / Q000032:analysis*; D003061:Codeine / Q000031:analogs & derivatives*; D006801:Humans; D006853:Hydrocodone / Q000378:metabolism / Q000506:poisoning*; D004091:Hydromorphone / Q000032:analysis* / Q000378:metabolism; D008297:Male
D006853:Hydrocodone; D004091:Hydromorphone; D003061:Codeine