Influence of methionine administration on serum alpha-fetoprotein levels in ethionine-injured rats.
Serum alpha-fetoprotein (AFP) concentrations increased promptly 2 days following a single injection of DL-ethionine (ethionine) in adult female rats. Continuous elevation of serum AFP was also observed on feeding a diet containing 1% ethionine for at least 2-3 weeks. A rise of serum AFP was not found if the diet was supplemented with 2.8% methionine. Furthermore, in rats fed on 1% ethionine for 2 weeks, dietary change to the laboratory chow supplemented with and without 2.8% methionine produced a decrease of increased serum AFP levels.
D000818:Animals; D005001:Ethionine / Q000633:toxicity*; D005260:Female; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008715:Methionine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins; D008715:Methionine; D005001:Ethionine