[Behavior of fetal hemoglobin during isoelectric focusing].
The results of isoelectrofusing applied to haemolysates of newborns, a case of beta thalassaemia and a case of hereditary persistence of fetal haemoglobin show that fetal haemoglobin F(alpha 2 gamma 2) can be oxidized into two products. The first corresponds to fetal ferrihaemoglobin (alpha +2 gamma +2), the oxidation product of the four Fe atoms of the molecule. The second, which is called fetal intermedial methaemoglobin, and has the same pH as adult ferrihaemoglobin A1, represents probably a product of partial oxydation of fetal haemoglobin.
D000328:Adult; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007525:Isoelectric Focusing / Q000379:methods; D008706:Methemoglobin / Q000032:analysis; D010084:Oxidation-Reduction; D011247:Pregnancy; D013789:Thalassemia / Q000097:blood
D008706:Methemoglobin; D005319:Fetal Hemoglobin
Comportement de l'hemoglobine foetale au cours de l'isoelectrofocalisation.