[Evidence of an immune mechanism for the regulation of hemostatic enzymes].
Direct evidence of immune control of enzymatic homeostasis in blood coagulation system is presented. Autoantibodies that inactivate the appropriate enzymes were isolated from the plasma gamma-fraction and serum of non-immunized animals by affinity chromatography on sorbents IIa- and Xa-sepharose. Immunoglobulins obtained had antienzymatic activity in pure systems and gave effects of cross reaction in the HIT.
D000818:Animals; D000906:Antibodies / Q000302:isolation & purification; D002417:Cattle; D003429:Cross Reactions; D004789:Enzyme Activation; D006487:Hemostasis; D007136:Immunoglobulins / Q000302:isolation & purification*; D011516:Prothrombin / Q000276:immunology*; D013917:Thrombin / Q000276:immunology*; D005719:gamma-Globulins / Q000276:immunology
D000906:Antibodies; D007136:Immunoglobulins; D005719:gamma-Globulins; D011516:Prothrombin; D013917:Thrombin
Dokazatel'stvo immunogo mekhanizma reguliatsii fermentov gemostaza.