A non-T:non-B cell bears I-A, I-E, I-J, and Tla (Qa-1?) determinants.
A non-T:non-B accessory cell in peritoneal washout or spleen-cell suspensions facilitates T-cell proliferative responses to the mitogen, concanavalin A. Utilizing monoclonal antibody, we show that this accessory cell bears the same I-A- and I-E-subregion controlled determinants as found on B cells. In addition, the same accessory cell bears a Tla(Qa-1?)-region and an I-J-subregion controlled determinant. This I-J determinant is also present on splenic accessory cells involved in in vitro antibody responses to sheep red blood cells. Data in a companion paper show that not all anti-I-J sera contain antibody reactive with the accessory cell, and suggest that T cells involved in the generation of suppressor activity and accessory cells bear different I-J-subregion controlled determinants.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D001202:Ascitic Fluid / Q000166:cytology; D003208:Concanavalin A / Q000494:pharmacology; D000939:Epitopes; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D008215:Lymphocytes, Null / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D013154:Spleen / Q000166:cytology; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins; D018800:Thy-1 Antigens; D003208:Concanavalin A