Implications of the reorganization of the cell genome for aging or immortalization of dividing cells in vitro.
Cellular aging or immortalization depends on random reorganization of the cell genome and is determined by chance, intrinsic properties of the cell and environmental factors. The probability of creating a new genetic progressively autonomous program is higher for some cells than for others and is increased by external events that introduce de novo information.
D000818:Animals; D002417:Cattle; D002470:Cell Survival; D002642:Chick Embryo; D002875:Chromosomes / Q000648:ultrastructure; D006224:Cricetinae; D004261:DNA Replication; D005347:Fibroblasts / Q000166:cytology; D005796:Genes; D006801:Humans; D051379:Mice; D008938:Mitosis; D012313:RNA / Q000096:biosynthesis; D011817:Rabbits; D051381:Rats
D012313:RNA