Effect of UV-B erythema of psoralen, trimethylpsoralen, and 8 methoxypsoralen.
The MED for UV-B was measured 2 h and 24 h after oral intake of Psoralen (P) 0.49 mg/kg in 10 healthy volunteers. MED was increased when UV exposure had taken place 2 h after intake. The same increase was observed after 0.24 mg/kg and 0.98 mg/kg, with a non-significant dose dependence. This effect was not detectable when UV exposure had taken place 24 h after oral intake of the drug. In a second experiment the effects of oral intake of both trimethylpsoralen (TMP) and 8 Methoxypsoralen (8 MOP) mg/kg, were assessed in 29 subjects. While TMP increased MED when taken 2 h before UV exposure (p less than 0.001), 8 MOP had the opposite effect (p less than 0.01). TMP effect was observed mainly in fair-haired people (p less than 0.05) and 8 MOP effect mainly in females (p less than 0.05).
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000139:chemically induced / Q000209:etiology*; D005260:Female; D005363:Ficusin / Q000494:pharmacology; D011564:Furocoumarins / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D014307:Trioxsalen / Q000494:pharmacology; D014466:Ultraviolet Rays
D011564:Furocoumarins; D005363:Ficusin; D008730:Methoxsalen; D014307:Trioxsalen