Is the retrograde axonal transport of 3H-5-HT a specific process of serotoninergic neurons?
The specificity of the retrograde axonal transport of 3H-serotonin (3H-5-HT) was radioautographically studied in the afferents to the olfactory bulb (O.B.). Injections of 3H-5-HT of different concentrations (10(-2), 10(-3), 10(-4) and 10(-5) M) were performed into the O.B. of catron pretreated rats. Following injection of 3H-5-HT (10(-2) M), a cytoplasmic perikaryal labeling was observed in the bulk of afferents to the O.B. (aminergic and non-aminergic neurons). When lower concentrations of 3H-5-HT (10(-5) M) were injected into the O.B., the retrograde labeling was only seen in the raphe dorsalis (RD) serotoninergic perikarya. The specificity of the uptake-retrograde transport of 3H-5-HT seems to depend on the selectivity of uptake by nerve terminals.
D000344:Afferent Pathways / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport; D009474:Neurons / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism*; D011903:Raphe Nuclei / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D012701:Serotonin