Thymic hormonal activity on human peripheral blood lymphocytes in vitro. II. Enhancement of the production of immune interferon by activated cells.
The thymic extract TP-1 significantly enhanced the production of immune interferon (IF) by human peripheral blood mononuclear cells in Con A- or Raji- but not PHA-induced cultures. TP-1 effect was more pronounced under conditions of low IF production. The effect was evident before cell proliferation took place and without necessary concurrent effect of TP-1 on the blastogenic response. TP-1 had no detectable effect on nonactivated cultures. The enhancement of IF production by TP-1 to the degree demonstrated here necessitates consideration of its possible effects in every assay of thymic hormones that involves lectin or allogeneic stimulation of lymphocytes.
D000998:Antiviral Agents; D002455:Cell Division; D003208:Concanavalin A / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013951:Thymus Hormones / Q000494:pharmacology*
D000998:Antiviral Agents; D010835:Phytohemagglutinins; D013951:Thymus Hormones; D003208:Concanavalin A; D007372:Interferons