Effect of histamine and H1 and H2 receptors antagonists on carbachol-induced wet-dog shakes in rats.
Intracerebroventricular administration of carbachol chloride induced a characteristic wet-dog shake response in rats. Histamine did not change the number of wet-dog shakes during a 60 min observation but intensified the number of episodes in the first 30 min of the experiment. Antagonists of H1 (thenalidine and antazoline) and H2 (cimetidine and ranitidine) receptors, attenuated carbachol-induced wet-dog shakes. It may be suggested that inhibition of the central histaminergic structures decreased central cholinergic activity.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D006632:Histamine; D002217:Carbachol