title: Increased alanine aminotransferase activity in the Huntington's disease putamen.
abstract: The activities of both mitochondrial and cytosolic forms of alanine aminotransferase are markedly increased in Huntington's disease putamen autopsy samples. This increase was not observed in rats with kainic acid lesions of the striatum, and suggests a considerable alteration of glutamate and pyruvate metabolism as a feature of Huntington's disease.
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology*; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000201:enzymology; D011699:Putamen / Q000201:enzymology*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011768:Pyruvate Dehydrogenase Complex; D000410:Alanine Transaminase; D005974:Glutamate-Ammonia Ligase; D007608:Kainic Acid