title: Further evidence for behaviorly induced hypoxic conditions in subordinate mice.
abstract: When two male mice fight to establish social rank, the subordinate exhibits marked splenomegaly, reticulocytosis and decreased hematocrit. Individuals were isolated at weaning, paired 3 weeks later for two 30-min encounter periods daily for up to 3 weeks. After 2 days and 1 week encounter periods, subordinates had significantly decreased levels of hemoglobin in the kidney compared to dominants and controls. Subordinates had increased ATP levels in blood after 1, 2 and 3 weeks of encounter, bone marrow erythroid hyperplasia, as well as a substantial increase in the erythropoietin titre and Fe99 incorporation in spleen and blood.
mesh_terms: D000255:Adenosine Triphosphate / Q000097:blood; D000374:Aggression; D000818:Animals; D001853:Bone Marrow / Q000502:physiology / Q000503:physiopathology; D004291:Dominance-Subordination; D004920:Erythropoiesis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology / Q000523:psychology*; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012930:Social Dominance; D013154:Spleen / Q000378:metabolism
chemical_list: D006454:Hemoglobins; D000255:Adenosine Triphosphate; D007501:Iron