[Interferon production during interaction between lymphocytes and L cell targets in different stages of the mitotic cycle].
Interferon is observed in culture medium in interaction of L-target cells (synchronized in the G1 and S phase and unsynchronized) with lymphocytes (intact, immune and actinomycin D-treated). Interferon production is induced after 30 min (20--25 units/ml) of interaction between immune lymphocytes and L cells in the G1 phase, reaches the maximum after 10 hours (70--75 units/ml) and slightly decreases after 48 hours (60--65 units/ml). In interaction of both immune and actinomycin D-treated lymphocytes with L cells in the G1 and S phase, interferon production correlates with the cytotoxic lymphocyte effect on these cells.
D000818:Animals; D002453:Cell Cycle; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D003609:Dactinomycin / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis*; D007739:L Cells / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008938:Mitosis; D013997:Time Factors
D003609:Dactinomycin; D007372:Interferons
Produktsiia interferona pri vzaimodeĭstvii limfotsitov s L-kletkami-misheniami, nakhodiashchimisia v razlichnykh fazakh mitoticheskogo tsikla.