Aromatization is cyclic AMP-dependent in cultured brain cells.
When added to primary cultures of adult turtle (Chrysemys) brain, dibutyryl cyclic AMP increases estrogen yields from [3H]testosterone in a dose- and time-dependent manner, although rat FSH, rat LH, and dibutyryl cyclic GMP are relatively ineffective. A phosphodiesterase inhibitor (MIX) by itself increases estrogen yields from the substrate and potentiates the response to dibutyryl cyclic AMP.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D004958:Estradiol / Q000096:biosynthesis; D004967:Estrogens / Q000096:biosynthesis*; D008297:Male; D013739:Testosterone / Q000378:metabolism*; D014426:Turtles
D004967:Estrogens; D013739:Testosterone; D004958:Estradiol; D003994:Bucladesine; D000242:Cyclic AMP; D015056:1-Methyl-3-isobutylxanthine