title: The variable region of human immunoglobulins. I. Serologic and structural correlations of antigenic markers common to V lambda I and V lambda IV proteins (isotypic cross-reactivities).
abstract: Sixty-eight human lambda-chain sources including representatives of the five different subgroups were studied for the distribution of the serologic markers ST, 111, and VOR  The variable region character of these antigenic determinants has been demonstrated for those proteins whose primary structures had been partially or completely determined previously. The lambda-chain sub-groups I and IV are readily distinguished antigenically but the specificity designated VOR is shared between them and is absent in the II, III, and V subtypes. The results of these studies are discussed with respect to the possible relationships of the structural genes controlling the synthesis of the lambda-chain subgroups, and some potential phylogenetic and functional meaning of the heterogeneities is revealed.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001666:Binding Sites, Antibody; D003429:Cross Reactions; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007146:Immunoglobulin lambda-Chains; D011817:Rabbits
chemical_list: D000939:Epitopes; D007106:Immune Sera; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007146:Immunoglobulin lambda-Chains