Protection by SK&F 93479 against the haemodynamic effects of coronary artery ligation in dogs.
The effects of SK&F 93479, a potent histamine H2-receptor antagonist, on the changes in haemodynamics induced by coronary artery ligation were investigated in anaesthetized dogs. Intravenous bolus injection of SK&F 93479 1 mg/kg followed by 1 mg/kg/h infusion caused transient decreases in systemic blood pressure, left ventricular pressure, and dLVP/dtmax, but did not significantly alter heart rate. Coronary artery ligation produced haemodynamic depression, and this was significantly prevented by pretreatment of the animals with SK&F 93479. These findings suggest that histamine may contribute to the haemodynamic changes arising from acute myocardial ischaemia.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008026:Ligation; D008297:Male; D011744:Pyrimidinones / Q000494:pharmacology*
D006635:Histamine H2 Antagonists; D011744:Pyrimidinones; C033275:SK&F 93479