[Prevention of antibody mediated dextran side effects by hapten inhibition in dogs (author's transl)].
The effectiveness of low molecular dextran (dextran 1) in preventing antibody mediated dextran side effects (hapten inhibition) was investigated in immunized dogs. After injection of clinical dextran (dextran 60) a rapid fall of systolic blood pressure and a decrease of leucocytes, thrombocytes and haemolytic complement activity was noted. The protective effect of a dextran 1 preinjection was clearly demonstrated; in contrast the built-in hapten injection (dextran + hapten together) was ineffective.
D000818:Animals; D000906:Antibodies / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D003911:Dextrans / Q000009:adverse effects* / Q000276:immunology / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D006241:Haptens / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male
D000906:Antibodies; D003911:Dextrans; D006241:Haptens
Verhinderung Antikörper-bedingter Dextran-Nebenwirkungen durch Hapten-Hemmung mit Dextran 1 am Hund.