Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin.
The amino acid sequences of mouse brain Thy-1 glycoproteins are shown to be homologous to those of variable-region immunoglobulin domains. There is also good homology with constant domains and beta 2-microglobulin; overall the results suggest that Thy-1 may be like the primordial immunoglobulin domain. Preliminary evidence for an invertebrate Thy-1 homolog supports this possibility.
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D005075:Biological Evolution; D000939:Epitopes; D006023:Glycoproteins / Q000276:immunology*; D007127:Immunoglobulin Constant Regions / Q000276:immunology; D007135:Immunoglobulin Variable Region / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology*; D007518:Isoantibodies / Q000096:biosynthesis; D011487:Protein Conformation; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D000939:Epitopes; D006023:Glycoproteins; D007127:Immunoglobulin Constant Regions; D007135:Immunoglobulin Variable Region; D007136:Immunoglobulins; D007518:Isoantibodies; D018800:Thy-1 Antigens