Continued presence of nucleoli in human germ cell tumors during mitosis.
A series of human germ cell-derived tumors were examined for the presence of nucleoli which persist through mitosis. Embryonal carcinomas, seminomas, and the cytotrophoblasts of choriocarcinomas had persistent nucleoli in more than 70% of mitoses. The differentiated cells derived from embryonal carcinomas, endodermal sinus tumors, and the more differentiated elements of choriocarcinomas only rarely had persistent nucleoli. These nucleoli appeared to remain transcriptionally active.
D002467:Cell Nucleus / Q000648:ultrastructure*; D002822:Choriocarcinoma / Q000648:ultrastructure; D004407:Dysgerminoma / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008938:Mitosis; D013194:Staining and Labeling; D013724:Teratoma / Q000648:ultrastructure; D013736:Testicular Neoplasms / Q000648:ultrastructure*