The role of calcium in the generation of intracellular SRS-A in passively sensitized human lung challenged with antigen.
Calcium deprivation inhibits the formation and subsequent release of SRS-A as well as histamine from passively sensitized human lung fragments challenged with antigen. Antimycin A inhibits the release of histamine and SRS-A in a dose dependant fashion, while causing a mild inhibition of SRS-A formation throughout the dose range studied. These data suggest that the influx of calcium is the critical event for the generation of SRS-A within the cell.
D000818:Animals; D000941:Antigens; D000968:Antimycin A / Q000494:pharmacology; D002118:Calcium / Q000172:deficiency / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology; D006168:Guinea Pigs; D006636:Histamine Release; D006801:Humans; D007116:Immunization, Passive; D013189:SRS-A / Q000096:biosynthesis*; D013696:Temperature
D000941:Antigens; D013189:SRS-A; D000968:Antimycin A; D003847:Deoxyglucose; D002118:Calcium