Restriction specificity of virus-specific cytotoxic T cells from thymectomised irradiated bone marrow chimeras reconstituted with thymus grafts.
Adult-thymectomised lethally mice A that were reconstituted with T-cell-depleted bone marrow cells of (A X B)F1 origin plus fetal thymus grafts of (B X C)F1 origin generated virus-specific T cells restricted to B alone; adult-thymectomised and lethally irradiated (A X B)F1 mice that were reconstituted with T-cell-depleted bone marrow cells of (A X B)F1 origin plus fetal thymus grafts of A and of B origin generated virus-specific T cells restricted to A or to B. These results do not reveal obvious suppressive influences of host or stem-cell origin that might have explained results obtained with various irradiated bone marrow or thymus chimeras, they indicate that the thymus' influence on maturing T cells is one of the limiting steps in the selection of T cells' restriction specificities.
D000818:Animals; D000956:Antigens, Viral; D001853:Bone Marrow / Q000528:radiation effects*; D016026:Bone Marrow Transplantation; D002678:Chimera; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006412:Hematopoietic Stem Cells / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy; D013950:Thymus Gland / Q000637:transplantation*; D014184:Transplantation, Homologous; D014616:Vaccinia virus / Q000276:immunology*
D000956:Antigens, Viral; D000939:Epitopes