title: Treatment of advanced breast cancer with megestrol acetate after therapy with tamoxifen.
abstract: The efficacy of megestrol acetate in the treatment of advanced (Stage IV) carcinoma of the breast was studied in 48 evaluable patients who had been initially treated with tamoxifen. Forty-five patients had previously responded to the tamoxifen therapy. Fifteen patients (31%) had partial remissions, sixteen patients (33%) had stable disease, and seventeen patients (36%) had progressively disease. The median response duration was seven months for responding patients and six months for disease-stable patients. These results suggest that megestrol acetate is an effective agent for the palliation of advanced breast cancer relapsing following response to tamoxifen therapy.
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008535:Megestrol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019290:Megestrol Acetate; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010166:Palliative Care; D011379:Prognosis; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D013629:Tamoxifen; D008535:Megestrol; D019290:Megestrol Acetate