[Effect of interferon on the expression of mouse mammary tumor virus (MMTV) in GR cells in culture].
Interferon treatment of GR cells markedly inhibits the production of MMTV as quantitated by hybridization of its viral RNA in the cell culture medium. The level of intracellular viral RNA and its rate of synthesis are however not modified by interferon. The intracellular levels of the major viral proteins as measured by immunoprecipitation remain unchanged. The intracellular level of the viral reverse transcriptase activity is reduced by about 40% as compared to more than 95% in the cell culture medium.
D000818:Animals; D007372:Interferons / Q000494:pharmacology*; D007700:Kinetics; D008325:Mammary Neoplasms, Experimental; D008324:Mammary Tumor Virus, Mouse / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000096:biosynthesis*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects
D012367:RNA, Viral; D014764:Viral Proteins; D007372:Interferons; D012194:RNA-Directed DNA Polymerase
Effets de l'interféron sur l'expression du virus des tumeurs mammaires de la souris (MMTV) dans des cellules GR en culture.