Interferon immunosuppression: mediation by a suppressor factor.
Suppression of the in vitro antibody response to sheep erythrocytes by mouse fibroblast interferon occurred by induction of suppressor cell activity in spleen cells. The suppressor cells produced a soluble factor which mediated the immunosuppression. The suppressor factor did not inhibit virus replication; thus, interferon probably regulates the B-cell response by a mechanism that is different from its antiviral effect.
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D007165:Immunosuppression Therapy; D007372:Interferons / Q000276:immunology / Q000494:pharmacology*; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007372:Interferons