Local kallikrein and trypsin responses in the rat.
1 Locally administered commercial hog pancreatic kallikrein (Depot-Glumorin) and bovine pancreatic trypsin both increased vascular permeability in the skin and paws of rats. 2 By the use of numerous antagonists and enzyme inhibitors, this vascular response was found to be the result not of kinin formation but of a direct action mostly on histamine receptors. 3 Highly purified kallikrein did not increase vascular permeability in rats, suggesting either that the effect was due to an impurity in the commercial preparation or that a structural change in the enzyme occurred on purification. 4 Soya bean trypsin inhibitor prevented the trypsin response when both were injected locally. On intraperitoneal injection, the inhibitor was effective only against local kallikrein. 5 The kallikrein inhibitor, aprotinin (Trasylol), was not effective against local kallikrein but it reduced the trypsin response when both were injected locally.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D004357:Drug Synergism; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D051381:Rats; D014357:Trypsin / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000494:pharmacology
D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D007328:Insulin; D014361:Trypsin Inhibitors; D006632:Histamine; D007611:Aprotinin; D007610:Kallikreins; D014357:Trypsin