Spiroperidol binding in the human caudate nucleus.
The displacement of spiroperidol binding by the optical isomers of butaclamol in synaptosomal preparations of the caudate nucleus obtained from parkinsonians and non-parkinsonians at post mortem were investigated. A group of spiroperidol binding sites found in the non-parkinsonians was less strongly expressed or absent in analogous tissue of the parkinsonian. The significance of these findings in relation to Parkinson's disease and its treatment are discussed.
D001667:Binding, Competitive; D002069:Butaclamol / Q000494:pharmacology; D002090:Butyrophenones / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D010300:Parkinson Disease / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism
D002090:Butyrophenones; D013134:Spiperone; D002069:Butaclamol