Enhancement of phenotypic instability by alpha-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions.
The effects of alpha-difluoromethylornithine (DFMO), butylated hydroxyanisole (BHA), sodium phenobarbital (PB) and 2-acetylaminofluorene (AAF) administration on the further development of rat liver nodular lesions induced in a short-term system were investigated. The results clearly demonstrated an association between DFMO and BHA treatment with reduction in numbers of persisting nodules as assayed histopathologically and by analysis of gamma-glutamyltranspeptidase (gamma GT) and glucose-6-phosphate dehydrogenase (G6PDH) positive populations. PB and to a lesser extent AAF, on the other hand, appeared to exert an opposite effect, apparently enhancing the phenotypic stability of the nodular putative preneoplastic lesions.
D015073:2-Acetylaminofluorene / Q000494:pharmacology; D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D004052:Diethylnitrosamine; D000518:Eflornithine; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D065108:Ornithine Decarboxylase Inhibitors; D010634:Phenobarbital / Q000494:pharmacology; D010641:Phenotype; D051381:Rats; D011916:Rats, Inbred F344; D013268:Stimulation, Chemical; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D000840:Anisoles; D065108:Ornithine Decarboxylase Inhibitors; D002083:Butylated Hydroxyanisole; D004052:Diethylnitrosamine; D015073:2-Acetylaminofluorene; D009952:Ornithine; D005954:Glucosephosphate Dehydrogenase; D005723:gamma-Glutamyltransferase; D010634:Phenobarbital; D000518:Eflornithine