[Cytological study of nucleoli and nucleolar organizers during inhibition of RNA synthesis].
Adenosine induces a massive nucleolar disorganization both in chick embryo fibroblasts and Ehrlich ascitic tumour cells in which the fibrillar centre is the only persistent structure. We discuss these observations in term of RNA synthesis inhibition as fibrillar centres are the Nucleolus-Organizing Regions (NOR's).
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure*; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts / Q000648:ultrastructure; D008854:Microscopy, Electron; D009369:Neoplasms / Q000648:ultrastructure; D009697:Nucleolus Organizer Region / Q000187:drug effects / Q000648:ultrastructure*; D012313:RNA / Q000096:biosynthesis*
D012313:RNA; D000241:Adenosine
Etude cytologique des nucléoles et des organisateurs nucleoaires lors d'une inhibition des synthèse d'ARN.