title: Biogenic amines in human brain in normal aging, senile dementia, and chronic alcoholism.
abstract: Postmortem examination of various brain regions of cases without known brain pathology showed an age-related decrease in the levels of dopamine in the nigrostriatal system, of norepinephrine in the hippocampus, and of 5-HT in the gyrus cinguli but an increase of 5-HT in the medulla oblongata and of MAO B in several brain regions.
mesh_terms: D008735:5-Methoxytryptamine / Q000378:metabolism; D000328:Adult; D000368:Aged; D000375:Aging; D000437:Alcoholism / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D003704:Dementia / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D012701:Serotonin; D008735:5-Methoxytryptamine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid