Treatment of cervical carcinoma with methotrexate, bleomycin and vincristine.
Seventeen patients with squamous cell carcinoma of the cervix received a combination of methotrexate, bleomycin, and vincristine. Oral methotrexate and parenteral bleomycin were given every week and intravenous vincristine was given every other week. Eight patients had partial response and one patient had a complete response. This study strongly supports the effectiveness of methotrexate, bleomycin, and vincristine against cervical malignancy.
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use*; D001855:Bone Marrow Diseases / Q000139:chemically induced; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000009:adverse effects / Q000627:therapeutic use*
D001761:Bleomycin; D014750:Vincristine; D008727:Methotrexate