[Experimental studies on the diffusion of antifibrinolytic agents in fibrin thrombi. A contribution to intrathecal antifibrinolytic therapy in subarachnoid hemorrhages].
The diffusion behaviour and the diffusion coefficients of antifibrinolytics in fibrin thrombi were determined by in vitro incubating attempts with tritium marked compounds of PAMBA, AMCA, and ECA as well as by chromogenic substrate determination for contrykal. The great diffusion ability of PAMBA supports the usefulness of intrathecal therapy of subarachnoidal bleeding for blocking endogenous fibrinolysis, whereas the exogenous fibrinolysis of the fibrin thrombus closing aneurysm is inhibited by the intrathecal application.
D010129:4-Aminobenzoic Acid / Q000378:metabolism; D000614:Aminocaproates / Q000378:metabolism; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D004058:Diffusion; D006801:Humans; D007278:Injections, Spinal; D007700:Kinetics; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy*; D014148:Tranexamic Acid / Q000378:metabolism; D062366:para-Aminobenzoates
D000614:Aminocaproates; D000933:Antifibrinolytic Agents; D062366:para-Aminobenzoates; C020858:cis-4-aminomethylcyclohexane-1-carboxylic acid; C015668:4-aminomethylbenzoic acid; D014148:Tranexamic Acid; D010129:4-Aminobenzoic Acid
Experimentelle Untersuchungen zur Diffusion von Antifibrinolytika in Fibrinabscheidungsthromben. Ein Beitrag zur intrathekalen antifibrinolytischen Therapie bei Subarachnoidealblutungen.