title: Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
abstract: The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology; D005354:Fibrosarcoma / Q000098:blood supply / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000098:blood supply / Q000473:pathology
chemical_list: D011448:Prostaglandin Antagonists; D004008:Diclofenac; D001241:Aspirin; D007213:Indomethacin