Studies concerning the viability of the preserved kidney with perfusates other than plasma.
Based on previous data, this research deals with the study of cellular ultrastructure of renal tissue (cortical and medullary) in conditions of preservation through a continuous hypothermic pulsatile perfusion, using a solution that substitutes plasma as the perfusate. This experiment was done on isolated dog kidneys perfused with a specialized perfusion machine. The results clearly show that with this method of renal preservation, no major lesions or irreversible modifications of the nephrons occur within 12 hours, offering the organ posttransplanting compatibility.
D000818:Animals; D003911:Dextrans / Q000494:pharmacology; D004285:Dogs; D005947:Glucose / Q000494:pharmacology; D007668:Kidney / Q000648:ultrastructure; D016030:Kidney Transplantation; D008278:Magnesium Sulfate / Q000494:pharmacology; D009926:Organ Preservation; D010400:Penicillin G / Q000494:pharmacology; D010477:Perfusion; D010952:Plasma Substitutes; D011189:Potassium Chloride / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology
D003911:Dextrans; D010952:Plasma Substitutes; D012965:Sodium Chloride; D011189:Potassium Chloride; D008278:Magnesium Sulfate; D005947:Glucose; D010400:Penicillin G