Intraocular antiviral penetration.
Aqueous levels of topically applied vidarabine monophosphate, trifluridine, and acyclovir were determined following topical administration in patients with normal corneas prior to cataract extraction. Meager levels in aqueous were found for vidarabine monophosphate, and none for trifluridine. Substantial levels of acyclovir were detected that were well within the therapeutic range of herpes simplex susceptibility.
D000212:Acyclovir / Q000378:metabolism* / Q000627:therapeutic use; D000287:Administration, Topical; D000998:Antiviral Agents / Q000378:metabolism* / Q000627:therapeutic use; D001088:Arabinonucleotides / Q000378:metabolism*; D005123:Eye / Q000378:metabolism; D005128:Eye Diseases / Q000188:drug therapy*; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects; D013936:Thymidine / Q000031:analogs & derivatives*; D014271:Trifluridine / Q000378:metabolism* / Q000627:therapeutic use; D001084:Vidarabine Phosphate / Q000378:metabolism* / Q000627:therapeutic use
D000998:Antiviral Agents; D001088:Arabinonucleotides; D001084:Vidarabine Phosphate; D014271:Trifluridine; D013936:Thymidine; D000212:Acyclovir