Effects of high dose application of lindane to rats and influence of L-ascorbic acid supplementation.
Oral application of lindane at a dose of 2 mg/100 g body weight of rat/day for 15 days produced alterations in the activities of several enzymes viz, glutamate oxaloacetate transaminase, alkaline phosphatase, acetylcholinesterase and inorganic pyrophosphatase in different organs and serum. Histological changes in liver and kidney tissues and changes in whole liver and liver plasma membrane lipids were also noted by chronic administration of lindane. Partial alleviation of the toxic symptoms with respect to some of these parameters were noted by high dose administration of L-ascorbic acid.
D000110:Acetylcholinesterase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011755:Pyrophosphatases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001556:Hexachlorocyclohexane; D001219:Aspartate Aminotransferases; D000110:Acetylcholinesterase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D011755:Pyrophosphatases; D001205:Ascorbic Acid