[Identification of rat sinus node pacemaker cells by intracellular injection of lanthanum ions].
Action potentials of pacemaker cells were recorded on an isolated preparation of rat right atrium. Lanthanum ions were injected via a recording microelectrode. The sinus node area was treated for electron microscopy. The electron-dense clusters of lanthanum ions were identified in pacemaker cell organelles, such as cytoplasmic and mitochondrial matrix, external membrane of mitochondria, and inner surface of cytolemma. Treatment with La3+ produced no significant alterations in cellular morphology.
D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D007811:Lanthanum; D008297:Male; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009210:Myofibrils / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012849:Sinoatrial Node / Q000166:cytology*; D013194:Staining and Labeling / Q000379:methods
D007811:Lanthanum
Identifikatsiia kletok--voditeleĭ ritma sinusnogo uzla serdtsa krysy metodom vnutrikletochnogo vvedeniia ionov lantana.