Evidence that celiac disease is primarily associated with a DC locus allelic specificity.
Sixty patients with celiac disease were typed by radioimmunoassay for the specificities HLA-DR3, HLA-DR7, and for an allelic specificity, DC3, of the HLA-associated DC locus. We found that celiac disease is primarily associated with the DC determinant. The previously described associations with DR3, DR7, B8, B13, and A1 can be explained by decreasing degrees of linkage disequilibrium with DC3.
D000293:Adolescent; D000483:Alleles; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D000939:Epitopes / Q000235:genetics / Q000276:immunology*; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D011863:Radioimmunoassay
D000939:Epitopes; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II