Trypsin-inhibitory activities of acid-stable fragments of the inter-alpha-trypsin inhibitor in inflammatory and uraemic conditions.
The concentration in serum of the acid-stable Mr 30.000 fragment of the Inter-alpha-Trypsin Inhibitor (SPI), and the acid-stable Mr 14.000 fragment of the inhibitor prepared by trypsin by digestion of the acid-precipitated serum proteins (API) was determined. A considerable increase in concentration of SPI and a decrease in concentration of API were observed in inflammatory conditions. In uraemic conditions the concentration of SPI was increased while that of API was unchanged.
D000328:Adult; D000510:Alpha-Globulins / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments; D011480:Protease Inhibitors / Q000097:blood; D014361:Trypsin Inhibitors / Q000097:blood*; D014511:Uremia / Q000097:blood*
D000510:Alpha-Globulins; D010446:Peptide Fragments; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; C011877:inter-alpha-inhibitor