Measurement of N tau-methylhistamine concentrations in urine as a parameter for histamine release by radiographic contrast media.
In a group of 750 patients who were admitted for excretory urography using iodamide, 14 distinct adverse reactions were observed. 2 of these patients exhibited a severe reaction, 4 a moderate reaction and 8 a mild reaction. In the urine portions collected 1 h after the administration of the contrast medium N tau-methylhistamine (an important histamine metabolite) was elevated both in patients showing severe adverse reactions and in those with moderate reactions. There was a rather good correlation between the increase of urinary N tau-methylhistamine concentrations and the severity of the reaction to iodamide.
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced; D003287:Contrast Media / Q000009:adverse effects; D005260:Female; D006636:Histamine Release; D006801:Humans; D007451:Iodamide / Q000009:adverse effects*; D007463:Iodobenzoates / Q000009:adverse effects*; D008297:Male; D008761:Methylhistamines / Q000652:urine*; D008875:Middle Aged; D014567:Urography
D003287:Contrast Media; D007463:Iodobenzoates; D008761:Methylhistamines; D007451:Iodamide