Suppression of chronic-relapsing experimental allergic encephalomyelitis in strain-13 guinea pigs by administration of liposome-associated myelin basic protein.
Juvenile strain-13 guinea pigs were challenged with isologous spinal cord in CFA. After recovery from the first EAE episode the animals were treated with guinea pig MBP inserted into liposomes, with cytochrome-c-liposomes, with MBP in saline or with MBP in IFA. Guinea pigs treated with MBP-liposomes showed a striking reduction in clinical signs and in the number and intensity of relapses. They displayed virtually no demyelinating lesions, and had comparatively little parenchymal inflammation in the spinal cord. Early T rosette levels showed an inverse correlation with the severity of histological lesions in the spinal cord but correlation with the clinical status at the time of rosette assay was less well defined.
D000818:Animals; D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007267:Injections; D008081:Liposomes / Q000008:administration & dosage*; D004676:Myelin Basic Protein / Q000627:therapeutic use*; D012397:Rosette Formation; D013116:Spinal Cord / Q000473:pathology; D013223:Statistics as Topic
D008081:Liposomes; D004676:Myelin Basic Protein