Inhibition of keratinocyte proliferation by extracts of Actinobacillus actinomycetemcomitans.
A heat-labile sonic extract of a nonleukotoxic strain of Actinobacillus actinomycetemcomitans caused a dose-dependent inhibition of proliferation of human keratinocytes. Exposure of cells to heat-labile sonic extract for periods as brief as 10 min produced significant suppression of [3H]thymidine uptake 72 h later. I propose that alteration of epithelial barriers may be one pathogenic mechanism of this organism.
D000188:Actinobacillus; D001427:Bacterial Toxins / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects*; D006358:Hot Temperature; D006801:Humans; D007633:Keratins / Q000096:biosynthesis; D008297:Male; D013997:Time Factors
D001427:Bacterial Toxins; D007633:Keratins