Malignant hemangiopericytoma with admixed glandular structures in breast and lung metastases. A light and electron microscopic and histochemical study of a case.
A 29-year-old woman with a malignant retroperitoneal hemangiopericytoma which metastasized to both breasts and the lung, is reported. The metastases in the breasts and the lung included numerous glandular structures. The light and electron microscopic, and histochemical analysis confirmed the diagnosis of hemangiopericytoma, and indicated that the glandular component was not a true part of the neoplasm but preformed glandular structures were included. The findings are discussed in relation to previous reports on low-grade leiomyosarcoma with glandular formation in lung metastases. The differential diagnosis against synovial sarcoma, which in monophasic forms may show a prominent pericytoma-like pattern, and in biphasic forms includes pseudoglandular structures, is discussed.
D000328:Adult; D001943:Breast Neoplasms / Q000556:secondary* / Q000648:ultrastructure; D005260:Female; D006393:Hemangiopericytoma / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009375:Neoplasms, Glandular and Epithelial / Q000648:ultrastructure; D012186:Retroperitoneal Neoplasms / Q000473:pathology*; D013194:Staining and Labeling