Investigation of the effect of cellular and viral nucleic acids against experimental influenza virus A/PR8/34 (H1N1) infection in mice.
Treatment of mice with different cellular nucleic acids prior to inoculation of influenza virus A/PR8/34 (H1N1) conferred--in some cases--a nonspecific protection against the experimental infection. The optimal amount of nucleic acid was 400 micrograms/mouse, irrespective of the origin or type of the macromolecule.
D000818:Animals; D002460:Cell Line; D002642:Chick Embryo; D004247:DNA / Q000494:pharmacology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus; D008099:Liver / Q000032:analysis; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D012313:RNA / Q000494:pharmacology*; D012343:RNA, Transfer / Q000494:pharmacology*; D012367:RNA, Viral / Q000494:pharmacology*; D013154:Spleen / Q000032:analysis; D013997:Time Factors
D012367:RNA, Viral; D012313:RNA; D004247:DNA; D012343:RNA, Transfer