[Specificity of the enzymes of Salmonella O-antigen biosynthesis. 6. Synthesis of sugar nucleotides with glycosyl phosphate activation. Analogs of guanosine diphosphate mannose modified at position 6 ofthe purine ring].
Interaction of alpha-D-mannopyranosyl phosphate with diphenyl phosphochloridate gave the trisubstituted pyrophosphate which was converted through the reaction with nucleoside 5'-phosphates into nucleoside 5'-(alpha-D-mannopyranosyl)pyrophosphates. The method was used for preparation of guanosine diphosphate mannose analogs derived from adenine, purine, 2-aminopurine, 2-amino-6-methoxypurine, 2-amino-6-chloropurine, and 2-amino-6-mercaptopurine. These analogs are necessary for study on substrate specificity of mannosyltransferases of Salmonella O-specific polysaccharides biosynthesis.
D000942:Antigens, Bacterial; D055598:Chemical Phenomena; D002621:Chemistry; D006156:Guanosine Diphosphate Sugars / Q000138:chemical synthesis*; D009702:Nucleoside Diphosphate Sugars / Q000138:chemical synthesis*; D019081:O Antigens; D011135:Polysaccharides, Bacterial / Q000138:chemical synthesis*; D012475:Salmonella / Q000276:immunology*
D000942:Antigens, Bacterial; D006156:Guanosine Diphosphate Sugars; D009702:Nucleoside Diphosphate Sugars; D019081:O Antigens; D011135:Polysaccharides, Bacterial
Spetsifichnost' fermentov biosinteza O-antigena salmonell. 6. Sintez nukleotidsakharov s aktivatsieĭ glikozilfosfata. Analogi guanozindifosfatmannozy, modifitsirovannye po polozheniiu 6 purinovogo iadra.