title: Immunological aspects of demyelination.
abstract: Important progresses made recently have allowed the development of markers that can be used to characterize the myelin oligodendrocyte compartment. Application of these immunological methods to the investigation of a wide range of disorders of the nervous system has proved extremely valuable. The author selects one example that concerns a group of demyelinating neuropathy associated with a monoclonal protein and presents evidence suggesting that one myelin constituent, a myelin associated glycoprotein, may induce autoimmunity in humans.
mesh_terms: D000911:Antibodies, Monoclonal / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis*; D003711:Demyelinating Diseases / Q000276:immunology*; D005699:Galactosylceramides / Q000276:immunology; D006801:Humans; D009185:Myelin Proteins / Q000276:immunology; D018992:Myelin-Associated Glycoprotein; D009457:Neuroglia / Q000276:immunology*; D009836:Oligodendroglia / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D005699:Galactosylceramides; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein