[Ultrastructure of rabbit myocardium in experimental histamine shock].
The ultrastructure of rabbit myocardium was studied after experimental histamine release by Polymyxin-B-sulphate. As soon as 15 minutes after the histamine release mitochondria and sarcoplasmic reticulum showed alterations with appearance of lysosomes and partial destruction of contractile structures. The sarcolemm formed blistered protrusions with simultaneously expelled cytoplasmic elements. Whereas intramural vessels were inconspicuous, the pericapillar spaces showed a considerable enlargement. On the basis of these findings, we suppose that the changes were induced on the one hand by the increase of the permeability of capillaries produced by histamine and, on the other one, by local and general ischemia as a consequence of shock.
D000818:Animals; D002199:Capillary Permeability; D005260:Female; D006636:Histamine Release; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure*; D011817:Rabbits; D012769:Shock / Q000473:pathology*; D013997:Time Factors
Elektronenmikroskopische Veränderungen am Kaninchenmyokard beim experimentellen Histaminschock.