On rat alpha-fetoprotein as a fatty acid carrier. Influence of the structure of fatty acids.
Fatty acids interfere with rat alpha-fetoprotein-estrogen interaction. We present here a quantitative study of the association constants for the binding to alpha-fetoprotein of different fatty acids. It can be concluded that fatty acids bind more strongly if the number of carbon atoms increases with the number of double bonds. The maximum binding ability occurred with the C20 fatty acids having three or four double bonds. As these fatty acids are the precursors in the synthesis of prostaglandins, we tested some compounds in this series and showed that prostaglandins presented no particular affinity for rat alpha-fetoprotein.
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004958:Estradiol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D000509:alpha-Fetoproteins / Q000378:metabolism*
D002352:Carrier Proteins; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D011453:Prostaglandins; D000509:alpha-Fetoproteins; D004958:Estradiol