Aphidicolin inhibits growth and DNA synthesis in halophilic arachaebacteria.
Aphidicolin, a specific inhibitor of eucaryotic alpha DNA polymerase, inhibits the growth of halophilic arachaebacteria. In Halobacterium halobium, aphidicolin prevents cell division and DNA synthesis. These results suggest that arachaebacterial replicases are of the eucaryotic type.
D000998:Antiviral Agents / Q000633:toxicity*; D016590:Aphidicolin; D001426:Bacterial Proteins / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects*; D004224:Diterpenes / Q000633:toxicity*; D006217:Halobacterium / Q000187:drug effects / Q000254:growth & development*; D007700:Kinetics; D012329:RNA, Bacterial / Q000096:biosynthesis
D000998:Antiviral Agents; D001426:Bacterial Proteins; D004224:Diterpenes; D012329:RNA, Bacterial; D016590:Aphidicolin