Characterization of two strains of selectively bred guinea-pigs. 2. Differences in immune response to synthetic polypeptides.
Two strains of guinea-pigs selectively bred for either high (IMM/S) or low (IMM/R) responsiveness to ovalbumin-induced respiratory anaphylaxis were examined for their immune response to a copolymer of L-glutamic acid and L-alanine (GA), a copolymer of L-glutamic acid and L-tyrosine (GT), and to a dinitro-phenyl derivative of a homopolymer of L-lysine (DNP-PLL). Considerable differences between the strains in development of cellular hypersensitivity and in the production of antibodies were observed. Guinea-pigs from IMM/S were all responders to GA and DNP-PLL and non-responders to GT, while guinea-pigs from two of three lines from IMM/R were responders to GT and non-responders to GA and DNP-PLL. The third IMM/R line showed an immune response pattern similar to guinea-pigs of strain IMM/S. Preliminary breeding studies confirmed that the immune response to these three antigens is under the control of dominant autosomal genes, since (IMM/S x IMM/R) F1 animals responded to all three antigens. It is concluded that these three antigens may serve as immune response markers in genetic studies of the differences between guinea-pigs from IMM/S and IMM/R in their ability to develop respiratory anaphylaxis.
D000409:Alanine / Q000031:analogs & derivatives / Q000276:immunology; D000707:Anaphylaxis / Q000235:genetics / Q000276:immunology; D000818:Animals; D005260:Female; D005802:Genes, MHC Class II; D006168:Guinea Pigs / Q000235:genetics* / Q000276:immunology; D006968:Hypersensitivity, Delayed; D036341:Intercellular Signaling Peptides and Proteins; D007428:Intradermal Tests; D008297:Male; D010455:Peptides / Q000276:immunology*; D011099:Polyglutamic Acid / Q000276:immunology; D011107:Polylysine / Q000031:analogs & derivatives / Q000276:immunology
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D011107:Polylysine; D011099:Polyglutamic Acid; C027606:L-glutamic acid-L-tyrosine copolymer; C036437:poly(glutamic acid-alanine); D000409:Alanine