Lack of asymmetrical distribution of receptor binding sites and of neurally active peptides within rat brain.
The high affinity binding of 5 tritiated (naloxone, spiroperidol, serotonin, quinuclidinylbenzilate, dihydroalprenolol) ligands to left and right frontal cortex, hippocampus and striatum has been compared in 8-week-old male rats. No lateralization of specific binding was observed between paired brain regions. Also, no regional asymmetry of protein content was found. No significant differences in met-enkephalin and substance P contents were found between paired striata, frontal cortex, and hippocampi. These data suggest that several neurotransmitter and neuromodulator indices are symmetrically distributed within the rat brain.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004292:Dominance, Cerebral / Q000502:physiology*; D004744:Enkephalin, Methionine / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D011956:Receptors, Cell Surface / Q000378:metabolism; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism; D013373:Substance P / Q000378:metabolism
D010455:Peptides; D011956:Receptors, Cell Surface; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D013373:Substance P; D004744:Enkephalin, Methionine