Anterior chamber associated immune deviation induced by TNP-splenocytes (TNP-ACAID). I. Systemic tolerance mediated by suppressor T-cells.
The relationship between the anterior chamber (AC) of the eye and the immune system was studied after intracameral inoculation with the hapten TNP. Injection of syngeneic TNP-modified splenocytes (TNP-Sp) into the AC of Balb/c mice results in suppressed systemic cell-mediated immunity to TNP as determined by the ear swelling assay. This aberrant immune responsiveness following AC injection of TNP-Sp has been termed TNP anterior chamber-associated immune deviation or TNP-ACAID. The phenomenon of TNP-ACAID is mediated by antigen-specific efferent suppressor T cells (Ts). The generation of Ts in TNP-ACAID requires a period of interaction between the intact eye and spleen, ie, the splenocameral axis.
D000818:Animals; D000867:Anterior Chamber / Q000276:immunology*; D000917:Antibody Formation; D000939:Epitopes; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009578:Nitrobenzenes / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology* / Q000494:pharmacology
D000939:Epitopes; D009578:Nitrobenzenes; D014301:Trinitrobenzenes