title: Serological comparison and antigenic relationships of seven serotypes of infectious bronchitis virus using the hemagglutination-inhibition test.
abstract: The antigenic relationships, antigenic spectrum, and immunogenicity of seven isolates of infectious bronchitis virus (IBV) were examined using the hemagglutination-inhibition (HI) test. Because there was a discontinuity of antigenic relationships and a high degree of cross-reactivity among serotypes of IBV in cross-hemagglutination-inhibition tests, the range of antigenic spectrum used to group the serotypes with the HI test should be wider than the limits suggested by the plaque-reduction test. The HI test may provide valuable information in monitoring the immune status of a flock following vaccination when the area has a history of infectious bronchitis infection. It may also be used as a rapid diagnostic test if a flock is experiencing an outbreak of a disease caused by emergence of a new type of IBV. Interpretation of HI titers in evaluating immune status of chickens following infection with IBV depends on further cross-challenge and cross-protection studies of various types of IBV.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology*; D002645:Chickens / Q000276:immunology; D003332:Coronaviridae / Q000276:immunology*; D003333:Coronaviridae Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D001351:Infectious bronchitis virus / Q000145:classification / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology / Q000382:microbiology; D012703:Serotyping
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes