gamma-Hexachlorocyclohexane stimulation of macrophage phospholipid hydrolysis and leukotriene production.
gamma-Hexachlorocyclohexane stimulates arachidonic acid release from macrophage phospholipids. It is also a powerful stimulator of leukotriene C4 production, yet (by comparison with zymosan) produces only a small effect on prostaglandin production. This suggests that synthesis of leukotrienes and prostaglandins can be independently regulated. The most likely mechanism of action of gamma-hexachlorocyclohexane is through its effect on phosphatidylinositol metabolism.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D005260:Female; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D006868:Hydrolysis; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D010743:Phospholipids / Q000378:metabolism*; D013189:SRS-A / Q000096:biosynthesis*
D001095:Arachidonic Acids; D010743:Phospholipids; D013189:SRS-A; D016718:Arachidonic Acid; D001556:Hexachlorocyclohexane