'Unicorn' among rats exposed to mycotoxins from Fusarium.
A horn-like nodule developed in the middle of the forehead of a white rat, exposed perinatally to T-2 toxin and to zearalenone, the secondary metabolites of Fusarium. The hard nodule consisted mainly of keratine, derived from a squamous carcinoma spreading through the nasal turbinals and invading the brain.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D007633:Keratins / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012118:Resorcinols / Q000633:toxicity*; D012717:Sesquiterpenes / Q000633:toxicity*; D012888:Skull Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013605:T-2 Toxin / Q000633:toxicity*; D015025:Zearalenone / Q000633:toxicity*
D012118:Resorcinols; D012717:Sesquiterpenes; D015025:Zearalenone; D007633:Keratins; D013605:T-2 Toxin