Axonal transport of nerve growth factor and serum albumin in the dystrophic mouse.
Specific (nerve growth factor, NGF) and non-specific (serum albumin, BSA) uptake followed by retrograde axonal transport was studied in the sciatic nerves of normal (C57BL/6J) and dystrophic (dy2J/dy2J) mice. In the dystrophic mouse there was a significant decrease in the amount of NGF transported to dorsal root ganglia or BSA accumulating at a ligature placed on the sciatic nerve.
D000818:Animals; D001370:Axonal Transport; D005727:Ganglia, Spinal / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D009414:Nerve Growth Factors / Q000378:metabolism*; D012584:Sciatic Nerve / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism*
D009414:Nerve Growth Factors; D012710:Serum Albumin, Bovine