[Role of serum factors in regulating interferon production].
A relationship between the level of interferon production, intensity of lipid peroxidation, the activity of proteolytic enzymes, and the age of the blood serum donor was established on a model of peritoneal exudate cells from mice of different ages. Trypsin was found to inhibit interferon production levels in the same way as did the serum of newborn mice. Introduction of protease inhibitor increased interferon production considerably. Unlike that of mature animals, the blood serum of newborn mice had prooxidant properties.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D007611:Aprotinin / Q000494:pharmacology; D001202:Ascitic Fluid; D001790:Blood Physiological Phenomena; D002478:Cells, Cultured; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis* / Q000528:radiation effects; D008054:Lipid Peroxides / Q000378:metabolism; D008315:Malondialdehyde / Q000494:pharmacology; D051379:Mice; D013997:Time Factors; D014357:Trypsin / Q000494:pharmacology; D014466:Ultraviolet Rays
D007369:Interferon Inducers; D008054:Lipid Peroxides; D008315:Malondialdehyde; D007372:Interferons; D007611:Aprotinin; D014357:Trypsin
Rol' syvorotochnykh faktorov v reguliatsii interfenonogeneza.