[Prophylactic and therapeutic activity of an interferon inducer in mice infected intracerebrally with rabies street virus].
Experiments in mice inoculated intracerebrally with street rabies virus demonstrated a protective effect of an interferon inducer (double-stranded RNA of phage f2). A high degree of protection was observed after intracerebral inoculation of the inducer both 24 h before and 4 h after virus infection, with a considerable increase of the average life-span of the animals. Intramuscular and intraperitoneal inoculation of the inducer proved ineffective.
D000818:Animals; D001435:Bacteriophages / Q000276:immunology; D001927:Brain Diseases / Q000517:prevention & control / Q000628:therapy; D005260:Female; D007369:Interferon Inducers / Q000627:therapeutic use*; D007372:Interferons / Q000032:analysis; D008297:Male; D051379:Mice; D012330:RNA, Double-Stranded / Q000276:immunology; D012367:RNA, Viral / Q000276:immunology; D011818:Rabies / Q000517:prevention & control* / Q000628:therapy; D013997:Time Factors
D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012367:RNA, Viral; D007372:Interferons
Profilakticheskaia i lechebnaia aktivnost' induktora interferona u mysheĭ, zarazhennykh v mozg ulichnym virusom beshenstva.