Distribution and stability of [111In]bleomycin and its fractions in tumor-bearing mice.
The tissue distributions in glioma-bearing mice given injections of [111In]bleomycin (BLM) indicated that tumor concentrations and ratios of tumor to blood, muscle and brain for [111In]BLM-B2 and -A2 were higher than those for unfractionated [111In]BLM. Autoradiographs of electrophoretic gels of urine containing [111In]BLM or one of its fractions differed from those containing 111InCl3. [111In]BLM and its fractions (A2 and B2) were found to be stable in vivo. The fractions may be more useful in the clinic than [111In]BLM.
D000818:Animals; D001345:Autoradiography; D001761:Bleomycin / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002855:Chromatography, Thin Layer; D004587:Electrophoresis, Agar Gel; D005910:Glioma / Q000000981:diagnostic imaging*; D007204:Indium; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000378:metabolism; D011868:Radioisotopes; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D011868:Radioisotopes; D007204:Indium; D001761:Bleomycin