title: Antibiotics from Basidiomycetes. XVI. Antimicrobial and cytotoxic polyines from Mycena viridimarginata Karst.
abstract: Two new biologically active polyines were isolated from cultures of the fungus Mycena viridimarginata. Their structures were elucidated by spectroscopic and chemical methods as 10-hydroxy-undeca-2,4,6,8-tetraynamide (1) and 3,4,13-trihydroxy-tetradeca-5,7,9,11-tetraynoic acid-gamma-lactone (2). The main component (1) is highly antibiotically active and cytotoxic.
mesh_terms: D000480:Alkynes / Q000096:biosynthesis / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D005658:Fungi / Q000187:drug effects; D053284:Polyunsaturated Alkamides; D053279:Polyynes; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
chemical_list: D000480:Alkynes; D000900:Anti-Bacterial Agents; D053284:Polyunsaturated Alkamides; D053279:Polyynes; D012313:RNA; C036018:10-hydroxy-undeca-2,4,6,8-tetraynamide; C036019:3,4,13-trihydroxy-tetradeca-5,7,9,11-tetraynoic acid-gamma-lactone; D004247:DNA