Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.
The growth rate (studied by mean tumor dry weight) and vascularization (studied by microangiography) of two transplantable rat tumors, a 20-methylcholanthrene-induced fibrosarcoma and a hepatoma, were significantly reduced by three prostaglandin synthesis inhibitors, indomethacin, diclofenac-sodium and aspirin, irrespective of whether the drugs were administered early or late during tumor growth.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology; D005354:Fibrosarcoma / Q000098:blood supply / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000098:blood supply / Q000473:pathology
D011448:Prostaglandin Antagonists; D004008:Diclofenac; D001241:Aspirin; D007213:Indomethacin