title: Cisplatin-induced changes in bleomycin elimination.
abstract: Bleomycin disposition was studied in two children who received at least six courses of vinblastine, bleomycin, and cisplatin. Total plasma clearance of bleomycin decreased from 39 to 18 ml/min/m2, while the terminal-phase half-life increased from 4.4 to 6.0 hrs since the cumulative cisplatin dose was greater than 300 mg/m2. In one patient, renal clearance of bleomycin decreased from 30 to 8.2 ml/min/m2. Changes in serum creatinine or BUN were not predictive of changes in bleomycin elimination.
mesh_terms: D000293:Adolescent; D001761:Bleomycin / Q000008:administration & dosage / Q000378:metabolism*; D002945:Cisplatin / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage*
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin