Developmental regulation of cytokeratins in cells of the rat mammary gland studied with monoclonal antibodies.
We have isolated two monoclonal antibodies to cytokeratins and determined their cell specificities. They display interesting localization within the rat mammary gland. One (1A10) shows specificity for myoepithelial cells; the other (24B42) is specific for lumenal cells at various stages of development. These two monoclonal antibodies and three others to cytokeratin previously isolated were used in conjunction with antibodies to myosin and collagen IV to confirm and extend our previous findings on epithelial cell types and development within the mammary gland.
D000375:Aging; D000818:Animals; D000911:Antibodies, Monoclonal; D005260:Female; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism*; D008297:Male; D008321:Mammary Glands, Animal / Q000254:growth & development*; D051381:Rats; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D007633:Keratins