Nuclear matrix from resting and concanavalin A-stimulated human lymphocytes.
Concanavalin A-induced transformation and proliferation of human peripheral blood lymphocytes was found to be accompanied by morphological and biochemical changes of the nuclear matrix. Nuclear matrix spheres increased in size as well as in protein and RNA content. Experimental data suggesting the involvement of the nuclear matrix in DNA replication processes are also presented.
D002467:Cell Nucleus / Q000378:metabolism / Q000648:ultrastructure*; D003208:Concanavalin A / Q000494:pharmacology*; D004261:DNA Replication; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism / Q000648:ultrastructure*; D009698:Nucleoproteins / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology; D012313:RNA / Q000378:metabolism
D009698:Nucleoproteins; D011480:Protease Inhibitors; D003208:Concanavalin A; D012313:RNA