Distribution of specific binding of [3H]promegestone in benign prostatic hypertrophy in regard to age, race and histological differences.
Progesterone receptors were measured in BPH tissues obtained via open prostatectomy on over thirty [30] patients. Specific receptor concentration was determined by computation of the suppressible binding from the 8S region of the glycerol density gradient (centrifuged in a vertical rotor) as described by McGuire and his colleagues. Measurable progesterone receptor concentrations were obtained from all thirty specimens. These patients were subsequently categorized on the basis of several parameters including age, race, and histology of the hyperplasia. Age and race groupings demonstrated no specific distribution pattern, however, there was a marked difference in mean receptor concentration between the histological classifications.
D000368:Aged; D000375:Aging; D044383:Black People; D002499:Centrifugation, Density Gradient; D006801:Humans; D008297:Male; D008875:Middle Aged; D011397:Promegestone / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology*; D011980:Receptors, Progesterone / Q000378:metabolism*; D044465:White People
D011980:Receptors, Progesterone; D011397:Promegestone