title: Immunoassay of acute phase reactants and Latex-CRP as activity tests in chronic staphylococcal osteomyelitis.
abstract: 20 patients with chronic staphylococcal osteomyelitis were tested for 6 acute phase reactants: alpha 1-antitrypsin, orosomucoid, haptoglobin, ceruloplasmin, C-reactive protein (CRP) and antichymotrypsin during different phases of the disease. CRP was best correlated to clinical activity and in 3 cases CRP and ceruloplasmin increased a few weeks before a clinically apparent exacerbation of the osteomyelitis took place. A Latex-CRP slide method showed fairly good agreement with CRP assessed by immunoassay. Determination of CRP is a suitable test for following the activity of chronic osteomyelitis.
mesh_terms: D000510:Alpha-Globulins / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis*; D002570:Ceruloplasmin / Q000032:analysis; D002908:Chronic Disease; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000097:blood; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007118:Immunoassay / Q000379:methods; D007840:Latex; D008297:Male; D009961:Orosomucoid / Q000032:analysis; D010019:Osteomyelitis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000097:blood* / Q000175:diagnosis; D014361:Trypsin Inhibitors / Q000097:blood; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000510:Alpha-Globulins; D006242:Haptoglobins; D007840:Latex; D009961:Orosomucoid; D014361:Trypsin Inhibitors; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein; D002570:Ceruloplasmin; D002918:Chymotrypsin