Cystic fibrosis serum stimulates mucin secretion but not calcium efflux from rat submandibular acini.
Cystic fibrosis serum stimulated release of mucins from rat submandibular acini to a significantly greater degree than did control serum. This action was not due to non-specific cell lysis, as monitored by lactate dehydrogenase release and was not accompanied by increases in 45Ca2+-efflux. The actions of cystic fibrosis serum and control serum in stimulating amylase release from rat exocrine pancreatic acini could not be distinguished. Thus, a specific action of cystic fibrosis serum in increasing mucin secretion, but not calcium permeability, in rat exocrine acini has been demonstrated.
D000293:Adolescent; D000328:Adult; D000681:Amylases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D013363:Submandibular Gland / Q000378:metabolism*
D009077:Mucins; D000681:Amylases; D002118:Calcium