Serum levels of radioreceptor-assayable somatomedins in children with minor neurodevelopmental disorders.
The somatomedins are a family of multitarget, growth-promoting hormones suggested to play a regulatory role in the central nervous system. Serum concentrations of somatomedins were determined by a radioreceptor assay in 26 patients (19 boys and 7 girls) with minor neurodevelopmental disorders. Five of these 26 patients showed high serum levels (greater than 2 S.D.) of somatomedins. It is concluded that patients with elevated concentrations of somatomedins might represent a pathogenetic subgroup.
D000293:Adolescent; D000328:Adult; D002352:Carrier Proteins / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D013002:Somatomedins / Q000097:blood*
D002352:Carrier Proteins; D013002:Somatomedins