Immunological tolerance to a non-cytopathic virus is not inheritable in mice.
Male lymphocytic choriomeningitis (LCM) virus-carrier mice were mated to uninfected females and their offsprings tested for (i) LCMV virus and (ii) their potential to generate LCM virus-specific cytotoxic T cells. Among about 500 offspring tested no example of antigen-independent inheritance of tolerance to LCM virus was detected. Therefore inheritance of acquired tolerance cannot be observed in this murine infectious disease model.
D000818:Animals; D002353:Carrier State / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007125:Immunogenetics; D008216:Lymphocytic Choriomeningitis / Q000235:genetics / Q000276:immunology*; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000939:Epitopes