Effects of conditioned media on extension of substance P-immunoreactive neurites from cultured mouse sensory ganglia.
Media conditioned by heart or stomach smooth muscle cells stimulated elongation of neurites with substance P-immunoreactivity from explants of mouse dorsal root ganglia in culture, but nerve growth factor (NGF) had no effect. However, NGF is known to be needed for sensory neurone survival; at least two types of factor may therefore be required for the normal development of substance P-containing sensory neurones.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D001369:Axons / Q000276:immunology* / Q000502:physiology; D003470:Culture Media / Q000494:pharmacology*; D005724:Ganglia / Q000166:cytology*; D005727:Ganglia, Spinal / Q000166:cytology*; D051379:Mice; D008815:Mice, Inbred Strains; D013373:Substance P / Q000276:immunology*
D003470:Culture Media; D013373:Substance P