Facilitated sexual behavior reversed and serotonin restored by raphe nuclei transplanted into denervated hypothalamus.
Fetal raphe cells transplanted into the hypothalamus reversed facilitation of feminine sexual behavior in rats with brain lesions induced by 5,7-dihydroxytryptamine. Immunocytochemical and chemical analyses of serotonin indicate that reinnervation of the ventromedial nucleus of the hypothalamus by the transplants is associated with behavioral recovery. The findings suggest that transplanted fetal tissue can exert functional regulation over an innate, complex, hormone-dependent behavior in adult rats.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D002369:Castration; D002395:Catecholamines / Q000032:analysis; D003714:Denervation; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005333:Fetus; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D007031:Hypothalamus / Q000502:physiology* / Q000601:surgery; D011903:Raphe Nuclei / Q000502:physiology* / Q000637:transplantation; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012726:Sexual Behavior, Animal; D013997:Time Factors
D002395:Catecholamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D004958:Estradiol; D006897:Hydroxyindoleacetic Acid