Inhibition of human antigen-specific T cell proliferation by anti-T blast sera.
Two antisera, one raised against activated human T lymphoblasts and one raised against the human T cell line HPB-ALL, have the ability to inhibit antigen-induced T cell proliferation. Antiproliferative activity is absorbed by T blasts and HPB-ALL cells, but not by B lymphoblastoid cell lines, alpha-ethylisothiouronium bromide-treated sheep red blood cell (AET-SRBC) receptor-negative lymphoid cells, or the T cell lines MOLT-4 and HSB. The effects of these antisera do not require the presence of complement and are not attributable to toxicity during culture. The F(ab')2 fragment of anti-T blast antiserum is also active.
D000042:Absorption; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D002460:Cell Line; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes; D006801:Humans; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D010835:Phytohemagglutinins / Q000494:pharmacology; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014373:Tuberculin / Q000276:immunology
D000961:Antilymphocyte Serum; D000939:Epitopes; D010835:Phytohemagglutinins; D014373:Tuberculin