Variations in cutaneous zinc concentrations after oral administration of zinc gluconate.
The assessment of zinc levels after oral administration of 100 mg of zinc gluconate was performed over a 72-hour period in 3 sectors: plasma, blister fluid and epidermis. The results show that zinc taken orally reaches the epidermis after 72 h and indicate the existence of an intermediary compartment between plasma and epidermis, represented by blister fluid, in which zinc concentration is 243.9 +/- 32.2 micrograms/l, that is, the ratio blister fluid/plasma = 0.33.
D000284:Administration, Oral; D000328:Adult; D005260:Female; D005942:Gluconates / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000032:analysis*; D013492:Suppuration / Q000378:metabolism; D015032:Zinc / Q000032:analysis*
D005942:Gluconates; D015032:Zinc; C030691:gluconic acid