Differential effects of adenosine on histamine secretion induced by antigen and chemical stimuli.
Adenosine had a dual effect on the IgE-mediated histamine secretion from rat peritoneal mast cells: an inhibition at relatively low concentrations and a potentiation at higher concentrations. An adenosine R-site analog, N6-methyladenosine, had a similar dual effect while adenosine P-site analogs, 9-beta-D-arabinofuranosyladenine and 2'-deoxyadenosine, had neither inhibitory nor potentiating effects. Both compound 48/80- and alpha-chymotrypsin-induced histamine secretion were dose-dependently inhibited by adenosine. Not only R- and P-site analogs of adenosine but also a wide variety of purine and pyrimidine derivatives such as adenine, AMP, cyclic AMP, ADP, guanosine, inosine and cytosine showed inhibitory activities on the compound 48/80-induced histamine secretion. Adenosine had no influence on substance P- and neurotensin-induced histamine secretion.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D000941:Antigens / Q000276:immunology*; D002918:Chymotrypsin / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects; D011983:Receptors, Purinergic; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000941:Antigens; D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; D002918:Chymotrypsin; D000241:Adenosine