Functional activities and concentrations of plasmin inhibitors in normal subjects and D.I.C. patients.
Alpha-2-macroglobulin and fast antiplasmin, the main inhibitors of the fibrinolytic system, and the presence of plasmin-antiplasmin complex (P-AP) were studied in 15 DIC patients and in 20 healthy individuals. There was a lack of correlation between immunological and chromogenic substrates alpha-2 antiplasmin levels when P-AP complex were found in DIC patients (in 6/15 cases). The levels of alpha-2-macroglobulin were within the normal range in most of these patients, confirm the secondary role of this inhibitor in fibrinolysis.
D000293:Adolescent; D000328:Adult; D000933:Antifibrinolytic Agents / Q000097:blood*; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D000933:Antifibrinolytic Agents; D000511:alpha-Macroglobulins; D010958:Plasminogen