title: Reversible acquisition of a host cell surface membrane antigen by Trypanosoma cruzi.
abstract: The ability of Trypanosoma cruzi, the etiological agent of Chagas' disease to acquire host cell surface antigen was tested. Parasites emerging after intracellular replication in WOS sarcoma monolayers expressed a sarcoma-associated surface antigen. This antigen was deleted from these parasites after replication in the MNS control monolayer, which does not express WOS sarcoma-associated surface antigen, or by replication in cell-free medium. This type of reversible acquisition of host surface antigen has not been previously described in T. cruzi or other intracellular protozoan parasites.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000954:Antigens, Surface / Q000032:analysis*; D002460:Cell Line; D014355:Chagas Disease / Q000276:immunology* / Q000469:parasitology; D000939:Epitopes; D006801:Humans; D012513:Sarcoma, Experimental / Q000276:immunology / Q000469:parasitology; D014349:Trypanosoma cruzi / Q000276:immunology
chemical_list: D000954:Antigens, Surface; D000939:Epitopes