Central effects of neuropeptides on ventilation in the rat.
We have examined the effects of centrally applied neuropeptides on ventilation (respiratory rate, tidal volume, and minute ventilation) in urethane-anesthetized rats. TRH caused an increase in respiratory rate, a decrease in tidal volume, but an increase in net minute ventilation. One TRH metabolite, acid TRH, caused similar changes, but no effect was observed from the other TRH metabolite, cHis-Pro. Both bombesin and calcitonin caused increases in minute ventilation due to increases in respiratory rate and tidal volume. Additionally, bombesin induced periodic sighing respirations at rates up to 15/minute which was observed with no other neuropeptide. Substance P, somatostatin, and neurotensin had no effect upon ventilation variables.
D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D002116:Calcitonin / Q000494:pharmacology; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009496:Neurotensin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects*; D013004:Somatostatin / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013990:Tidal Volume
D009419:Nerve Tissue Proteins; D010455:Peptides; D013373:Substance P; D009496:Neurotensin; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D002116:Calcitonin; D001839:Bombesin