[Substance P and microcirculation during stress].
The experiments have been made on rats with the use of animals' immobilization on the back during 1 or 24 h as a stressor. Intravital study of the microcirculation in the rat mesentery has shown that P substance in a concentration of 7 X 10(-8) M aggravated the disturbances caused by the immobilization, while antiserum to P substance with an activity of 150 ng SP/equiv. normalized the microcirculation. The action of P substance and antiserum was similar as regards disturbances of vascular permeability for colloid carbon particles. It is concluded that P substance participates in the mechanisms of microcirculatory and vascular permeability disturbances during stress.
D000818:Animals; D002199:Capillary Permeability; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D008833:Microcirculation / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D013152:Splanchnic Circulation; D013312:Stress, Physiological / Q000503:physiopathology*; D013373:Substance P / Q000276:immunology / Q000494:pharmacology / Q000502:physiology*
D007106:Immune Sera; D013373:Substance P
Veshchestvo "P" i sistema mikrotsirkuliatsii pri stresse.