title: Action of testosterone on RNA synthesis in the rat uterus.
abstract: The effect of testosterone on transcription was investigated in the uterus of the ovariectomized rat. Testosterone rapidly depressed both RNA polymerase A and B activities for up to 2 h after administration. Thereafter, RNA polymerase A activity increased, reaching control values at 4 h, and remained constant. On the contrary, RNA polymerase B activity remained depressed at 6 and 18 h after the administration of testosterone. The cellular entities or mechanisms which testosterone uses to alter transcription in the cell nucleus remain to be determined.
mesh_terms: D000818:Animals; D002369:Castration; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects*
chemical_list: D013739:Testosterone; D012313:RNA; D012321:DNA-Directed RNA Polymerases