The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF, from subarachnoid haemorrhage patients, on isolated tissues.
Peri-aneurysmal CSF was obtained at operation from 13 patients with subarachnoid haemorrhage from ruptured intracranial aneurysms. The 5-hydroxytryptamine antagonist ketanserin inhibited contractions of isolated human intracranial arteries, elicited by this CSF. The presence of 5-HT in CSF was confirmed by high performance liquid chromatography. The use of ketanserin in the therapy of postoperative cerebral vasospasm is discussed.
D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D002532:Intracranial Aneurysm / Q000134:cerebrospinal fluid / Q000601:surgery; D007431:Intraoperative Complications / Q000188:drug therapy; D002546:Ischemic Attack, Transient / Q000188:drug therapy; D007650:Ketanserin; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy; D051381:Rats; D012422:Rupture, Spontaneous; D012701:Serotonin / Q000134:cerebrospinal fluid*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid / Q000601:surgery*; D014661:Vasoconstriction / Q000187:drug effects*
D010880:Piperidines; D012702:Serotonin Antagonists; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D007650:Ketanserin