[Determination of dipeptidyl aminopeptidase activities in the cerebrospinal fluid].
The investigation of enzyme activity in cerebrospinal fluid has been without relevant results for laboratories analysing spinal fluid. For neurochemical purposes, it is interesting that the Substance P is convered by Depeptidyl-aminopeptidase IV (DP IV), liberating dipeptides. The hydrolysis of nitroanilids of the form Xaa-Pro-NHNp in cerebrospinal fluid was analysed using them as peptidases substrates. Finally a method for measuring the activity was proposed.
D004151:Dipeptides / Q000134:cerebrospinal fluid; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000134:cerebrospinal fluid*; D010450:Endopeptidases / Q000134:cerebrospinal fluid*; D006801:Humans; D007700:Kinetics; D013373:Substance P / Q000134:cerebrospinal fluid
D004151:Dipeptides; D013373:Substance P; D010450:Endopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Untersuchungen zur Bestimmung von Dipeptidyl-aminopeptidase-Aktivitäten im Liquor cerebrospinalis.