[Fibrinolysis and complement-system profiles during aorto-femoral bypass implantation].
In 51 patients undergoing either implantation of an aortofemoral bypass (38 patients) or of an saphenous bypass (13 patients) the fibrinolytic and complement system profiles were determined. During the course of an aortofemoral bypass the plasminogen concentration decreased by 40%, alpha 2-macroglobulin by 25%, the complement factor C3c by 20% and the complement factor C4 by 40%. Antithrombin III concentration remained stable until the third postoperative day. The alpha 1-antitrypsin concentration increased postoperatively by 40% compared to the preoperative control. The concentrations of plasminogen, antithrombin III, alpha 2-macroglobulin and complement factor C4 did not change in the patients undergoing saphenous bypass operation. Intraoperatively the complement factor C3c decreased by 20%, while alpha 1-antitrypsin showed postoperatively an increase by 30%. Anaesthesia (neuroleptanaesthesia, halothane- or continuous thoracal epidural anaesthesia) had no influence on the fibrinolytic and complement system profiles. Neither could a correlation be shown between the intraoperative haemodynamic changes and the concentrations of the factors of the fibrinolytic and complement system.
D000768:Anesthesia, General; D000990:Antithrombin III / Q000378:metabolism; D001011:Aorta / Q000601:surgery*; D003165:Complement System Proteins / Q000502:physiology*; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D005342:Fibrinolysis; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000378:metabolism; D013997:Time Factors; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D000990:Antithrombin III; D010958:Plasminogen; D003165:Complement System Proteins
Fibrinolyse- und Komplementsystem-Profile während aortofemoraler Bypassimplantation.