The histamine releasing activity of the industrial agent--Fasavin E4.
The effect of an industrial agent--Fasavin E4, on isolated rat mast cells has been investigated. It was shown that Fasavin E4 released histamine in concentration dependent fashion. The reaction was neither calcium nor energy dependent. It is concluded that histamine release induced by Fasavin E4 does not conform to secretion and possibly occurred due to membrane damage by cytolytic process.
D000818:Animals; D002118:Calcium / Q000502:physiology; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008407:Mast Cells / Q000378:metabolism; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013783:Textile Industry
D011092:Polyethylene Glycols; C038257:fasavin E4; D002118:Calcium