Platelet-associated IgG in patients with lymphoma.
Levels of platelet-associated IgG (PA-IgG) were studied in 72 patients with Hodgkin's (HD) and non-Hodgkin's lymphoma (NHL). Thirty-nine percent of patients with HD and 20% of patients with NHL had elevated PA-IgG levels. There was a positive correlation between disease activity and the presence of PA-IgG in HD and NHL. In patients with HD, PA-IgG strongly correlated with extent of disease and may serve as a marker of disease activity. PA-IgG may have facilitated platelet destruction in 5 of 11 thrombocytopenic patients with HD and increased PA-IgG and in 2 patients with HD and increased PA-IgG who developed severe thrombocytopenia when treated with chemotherapy.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000276:immunology; D013921:Thrombocytopenia / Q000150:complications / Q000276:immunology; D005719:gamma-Globulins / Q000032:analysis
D007074:Immunoglobulin G; D005719:gamma-Globulins