Effect of CaCl2 on production of interferon and synthesis of its mRNA in human MG-63 cells.
The effect of excess CaCl2 addition on the production of interferon and synthesis of its mRNA in a human cell line was investigated. Human MG-63 cells which were treated with 7 mM CaCl2 after poly(rI).poly(rC) induction produced 3 to 10 times as much interferon as control cells. Increased interferon mRNA activity was obtained from CaCl2 treated cells, suggesting that there was an increased interferon mRNA production in these cells.
D000818:Animals; D002122:Calcium Chloride / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D014981:Xenopus
D007369:Interferon Inducers; D012333:RNA, Messenger; D007372:Interferons; D002122:Calcium Chloride