Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.
A major antibody combining site on foot and mouth disease virus (FMDV) serotype O1K has been identified in a predicted surface helix of viral protein 1 (VP1) between amino acid residues 144 and 159. A hexadecapeptide covering this sequence elicits high titers of antibodies that specifically recognize and neutralize FMDV. The high quality of the immune response is attributed to a particularly stable conformation of the antigenic amino acid sequence, which is most likely an alpha-helix.
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral / Q000235:genetics; D005537:Aphthovirus / Q000235:genetics / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000032:analysis*; D005814:Genes, Viral; D012703:Serotyping
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D000939:Epitopes