Specific and nonspecific T-cell-mediated suppression of antihost immune reactivity in graft-versus-host reaction.
Intravenous immunization of mice with irradiated (2000 rads) allogeneic lymphoid cells induces the generation of suppressor T cells. Such suppressor T cells are capable of suppressing the antihost immune reactivity during acute and delayed graft-versus-host reactions. These suppressor T cells are strictly antigen-specific as far as their activation is concerned, but also suppress the reaction against unrelated antigens presented by the irradiated host.
D000818:Animals; D016026:Bone Marrow Transplantation; D000939:Epitopes; D005260:Female; D006087:Graft vs Host Reaction / Q000528:radiation effects; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000276:immunology; D007116:Immunization, Passive; D008213:Lymphocyte Activation; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000939:Epitopes