title: Morphofunctional findings in adenocarcinoma of endometrium.
abstract: Ten cases of adenocarcinoma of the endometrium were studied using histochemical methods for mucopolysaccharides and immunocytochemical methods for the localization of various markers, such as EMA (epithelial membrane antigen), GCDFP-15 (gross cystic disease fluid protein) and CEA. Four cases appeared to contain High Iron Diamine-positive substance and 6 cases were positive using an immunocytochemical method with a polyclonal anti-CEA antiserum. In contrast, no cases stained when a monoclonal anti-CEA antiserum was employed. This suggested that HID- positive material could be a sign of differentiation towards cells with a secretory function.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D001053:Apolipoproteins; D053399:Apolipoproteins D; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002352:Carrier Proteins; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008565:Membrane Proteins / Q000032:analysis; D026901:Membrane Transport Proteins; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D013194:Staining and Labeling; D014594:Uterine Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
chemical_list: C024328:APOD protein, human; D000951:Antigens, Neoplasm; D001053:Apolipoproteins; D053399:Apolipoproteins D; D002272:Carcinoembryonic Antigen; D002352:Carrier Proteins; D006023:Glycoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D018396:Mucin-1; D009077:Mucins; D009363:Neoplasm Proteins; C488892:PIP protein, human