Persistence of interferon action in mouse cells permeabilized with lysolecithin.
DNA synthesis, as measured by incorporation of [(3)H]TTP, was inhibited in Swiss mouse 3T3 cells treated with interferon and subsequently permeabilized with lysolecithin. The degree of inhibition observed was similar in intact or permeabilized cells. The interferon-induced antiviral state was retained in permeabilized cells.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004686:Encephalomyocarditis virus / Q000254:growth & development; D007372:Interferons / Q000494:pharmacology*; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D051379:Mice; D012367:RNA, Viral / Q000096:biosynthesis; D013936:Thymidine / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D008244:Lysophosphatidylcholines; D012367:RNA, Viral; D004247:DNA; D007372:Interferons; D013936:Thymidine