Influence of interferon induction with influenza a virus upon the modification of anti-SRBC humoral response.
The investigations carried out showed the dependence of immunosuppression induced by A/USRR/053/74(H3N2) virus upon the activity of its neuraminidase. High activity of this enzyme influenced interferon (IFN) induction which, in turn, reduced the primary humoral response to sheep red blood cells (SRBC) or stimulated the production of IgM and IgG antibody producing cells.
D000818:Animals; D000917:Antibody Formation; D004912:Erythrocytes / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D009980:Influenza A virus / Q000201:enzymology / Q000276:immunology*; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D009439:Neuraminidase / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007372:Interferons; D009439:Neuraminidase