title: Metabolism of alpha-hexachlorocyclohexane. Free metabolites in urine and organs of rats.
abstract: k1. The alpha-isomer of 1,2,3,4,5,6-hexachlorocyclohexane (HCH) is converted in rats to 1,2,4-trichlorobenzene, 2,3,4-trichlorophenol, 2,4,6-trichlorophenol, other trichlorophenols, and 2,3,4,6-tetrachlorophenol, which were excreted in urine. 2. Alpha-HCH is also converted to 3,4,6/5-pentachlorocyclohexene which is detectable in kidneys, but not in urine. 3. The results of this study are discussed with references to earlier work and to gamma-HCH metabolism.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D001556:Hexachlorocyclohexane / Q000378:metabolism* / Q000652:urine; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D001556:Hexachlorocyclohexane