Aprotinin in acute pancreatitis: effect on the plasma kallikrein-kinin system.
The effect of aprotinin ("Trasylol") on the plasma kallikrein-kinin system was studied in 44 patients with acute pancreatitis. 21 of these patients received aprotinin while 23 did not receive such treatment. It is concluded that an activation of the plasma kallikreinkinin system occurs in acute pancreatitis. Aprotinin was not found to inhibit this activation.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood / Q000188:drug therapy*; D011288:Prekallikrein / Q000032:analysis
D007704:Kininogens; D007705:Kinins; D011288:Prekallikrein; D007611:Aprotinin; D007610:Kallikreins