Inhibition of hyaluronidase by dextran sulfate and its possible application in anticancer treatment.
Hyaluronidase is competitively inhibited by dextran sulfate. Hyaluronidase depolymerizes the amorphous component of the interstitial connective tissue and therefore supports tumor spread and metastasis. These processes may be reduced by dextran sulfate.
D000970:Antineoplastic Agents; D003238:Connective Tissue / Q000201:enzymology*; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D007700:Kinetics; D008970:Molecular Weight; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D003911:Dextrans; D016264:Dextran Sulfate; D006821:Hyaluronoglucosaminidase