Clinical course and results of treatment of erythroleukaemia.
13 patients with erythroleukaemia were observed between 1971-1982. The initial laboratory findings revealed normocytic anaemia with the presence of erythroblasts up to 73% of nucleated cells. The leukocyte count was normal in 5 patients, low in 5 patients and elevated in the rest. Thrombocytopenia was present in all patients. The bone marrow showed hyperplasia of erythroid series. In the majority of cases structurally abnormal erythroblasts could be found. Myeloblasts in peripheral blood and bone marrow were found at diagnosis in 12 patients. In the terminal phase, the bone marrow showed the picture of acute granulocytic leukaemia, only in one patient of acute monoblastic leukaemia. Partial remission was obtained in 6 patients, the rest did not respond to any protocol. Survival time amounted to 2 to 30 months after diagnosis.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001215:Asparaginase / Q000627:therapeutic use; D001772:Blood Cell Count; D001856:Bone Marrow Examination; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000166:cytology; D013866:Thioguanine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D003561:Cytarabine; D014750:Vincristine; D001215:Asparaginase; D013866:Thioguanine