title: [Interferon induction in calves after experimental infection with bovine herpesvirus 1].
abstract: A total of 9 calves were used to test the interferon-inducing activity of strain Vulchedrum of the bovid Herpes virus 1. The virus of stomatitis vesiculosa adapted to cell cultures of calf kidney was used as an indicator of interferon. The antiviral action of interferon was demonstrated in the serum and the nose discharge of calves. The dynamics of interferon production in calves varied, depending on the venous, muscular, and tracheal route of application of the virus. Highest interferon titer in the serum was established at the venous application. In the nose discharge highest titers were found following tracheal application. Additional criteria demonstrating the presence of interferon in the positive serum and discharge samples were the unchanged activity at pH 2 and 4 degrees C for 24 hours; the unchanged activity following heating at 56 degrees C for 30 min; the unchanged activity following treatment with ether; the lack of activity following heating at 25 degrees C for 30 min; and the lack of activity at incubation with trypsin. The positive samples showed also antiviral unspecificity--inhibited was not only the virus of stomatitis vesiculosa, but also M. parainfluenza-3.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D006564:Herpesviridae / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology / Q000662:veterinary*; D007372:Interferons / Q000032:analysis / Q000096:biosynthesis*; D013997:Time Factors; D014776:Virus Cultivation
chemical_list: D007372:Interferons
vernacular_title: Induktsiia na interferon u teleta sled eksperimentalno zaraziavane s bovidniia kherpesvirus 1.