Silent lupus nephritis among patients with discoid lupus erythematosus.
A kidney biopsy was performed in 7 hypocomplementemic discoid lupus erythematosus patients despite the absence of overt renal involvement. Five patients had glomerular immune deposits and 2 patients with disseminated discoid lupus erythematosus exhibited definite proliferative glomerulonephritis. Those findings show that silent lupus nephritis may be encountered in discoid as well as in systemic lupus erythematosus, providing additional evidence supporting the unity of the disease. We suggest that hypocomplementemic patients with discoid lupus erythematosus must be carefully screened for renal disease by periodic urinalysis examinations.
D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D008179:Lupus Erythematosus, Discoid / Q000150:complications* / Q000276:immunology
D003176:Complement C3; D003181:Complement C4; D003165:Complement System Proteins