Permeability increase in black lipid membrane induced by compound 48/80.
When compound 48/80, a potent histamine liberator, was added in the aqueous phase facing the black lipid membrane, the conductivity of the membrane was remarkably increased. Although valinomycin displayed a distinct selectivity for K+ movement, such selection for ionic permeability was not observed in the case of compound 48/80.
D000818:Animals; D002784:Cholesterol; D004553:Electric Conductivity; D006636:Histamine Release / Q000187:drug effects; D008081:Liposomes; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology*; D008954:Models, Biological; D010539:Permeability; D010713:Phosphatidylcholines; D051381:Rats; D011919:Rats, Inbred Strains; D014634:Valinomycin; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D008081:Liposomes; D010713:Phosphatidylcholines; D014634:Valinomycin; D003189:p-Methoxy-N-methylphenethylamine; D002784:Cholesterol