Modification of rat brain 5-hydroxytryptamine metabolism by sublethal doses of organophosphate agents.
The early and late effects of sublethal doses of two organophosphate agents (paraoxon and soman) on 5-hydroxytryptamine (5-HT) metabolism were investigated in several rat brain areas. Parallel determinations of acetylcholinesterase (AcChE) inhibition were performed. An increase in 5-HT level was observed during the first phase of soman intoxication and a rise in 5-hydroxyindol acetic acid (5-HIAA) appeared in the early and late effects of both anticholinesterase agents with a predominant action in the striatum. These data suggested that paraoxon and soman induce a long-lasting increase in 5-HT turnover. This action cannot be related neither to the AcChE inhibition nor to the acetylcholine level.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010261:Paraoxon / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D012999:Soman / Q000494:pharmacology
D009943:Organophosphorus Compounds; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D012999:Soman; D000110:Acetylcholinesterase; D010261:Paraoxon; D010134:Fenclonine