Complexes of acid alpha 1-glycoprotein with immunoglobulins G in normal human blood serum.
DEAE-cellulose chromatography was applied for isolation of the complexes of acid alpha 1-glycoprotein (alpha 1-AGP) with immunoglobulins G (IgG). The heterogeneous glycoprotein fraction V was found to contain 75% of total alpha 1-AGP complexed with IgG3, as identified by Protein A-Sepharose chromatography. The results obtained indicate that in normal blood serum 30% of IgG3 and 75% of alpha 1-AGP are bound in the IgG3 - alpha 1-AGP complexes, whereas the remaining parts of IgG3 and alpha 1-AGP are present in free form.
D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D046911:Macromolecular Substances; D011485:Protein Binding; D000511:alpha-Macroglobulins / Q000378:metabolism*
D007074:Immunoglobulin G; D046911:Macromolecular Substances; D000511:alpha-Macroglobulins