[Use of a thymus polypeptide preparation to diagnose and correct immune deficiency states in multiple sclerosis].
Thymus-dependent immunity as well as thymic factor and corticosteroid influence upon it were studied in 36 patients with disseminated sclerosis. The illness was diagnosed according to the Poser system with the help of the spontaneous erythrocyte rosette test. The sensitivity of T lymphocytes to thymaline, to basic myelin protein and to prednisolone was analyzed. The Soviet drug thymaline, obtained from calf thymus, was first used for the treatment of disseminated sclerosis. Clinical and immunological results turned out positive. The possibility of differential immunomodulating therapy of disseminated sclerosis is shown.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy*; D007958:Leukocyte Count; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis; D004676:Myelin Basic Protein / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects; D013951:Thymus Hormones / Q000494:pharmacology / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D004676:Myelin Basic Protein; D013951:Thymus Hormones; C032805:thymalin; D011239:Prednisolone
Primenenie polipeptidnogo preparata timusa dlia diagnostiki i korrektsii immunodefitsitnogo sostoianiia pri rasseiannom skleroze.