title: The effect of carbachol and isoprenaline on cell division in the exocrine pancreas of the rat.
abstract: The effect of muscarinic cholinergic receptor stimulation on pancreatic acinar cell division has been investigated. Muscarinic receptor stimulation, in addition to causing a 50% depletion of amylase in the pancreas after 4 h, resulted in a 400% increase in the incorporation of [6(-3)H]thymidine 27 h after drug administration. This increase in incorporation was dose-dependent. Autoradiography showed this increase to be due to an increased acinar cell labelling. Isoprenaline also increased the incorporation of [6(-3)H]thymidine into the pancreas but did not reduce enzyme levels. However, with isoprenaline there was no increase in acinar cell labelling. The possibility of a relationship between secretion and hyperplasia of acinar cells in the rat pancreas is discussed.
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D006965:Hyperplasia; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects
chemical_list: D011976:Receptors, Muscarinic; D002217:Carbachol; D004247:DNA; D000681:Amylases; D007545:Isoproterenol