Has the raphe dorsalis nucleus an asymmetric function?
Differential pulse voltammetry (DPV) was used to measure 5-hydroxyindoles in the striata of anaesthetized rats. The amplitude of the voltammetry peaks in both striata decreased when 5-hydroxytryptophan (5-HTP) or 5-hydroxytryptamine (5-HT) was injected into the left side of the raphe dorsalis nucleus (RDN), but increased when either substance was injected into the right side. These findings indicate that the 5-hydroxyindole based communication between the striata and the RDN has a lateral asymmetry. The data are discussed with reference to histological observations suggesting a higher density of 5-hydroxyindole containing cell bodies in the lateral region than in the midline of this "unpaired" nucleus.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D003342:Corpus Striatum / Q000032:analysis / Q000502:physiology*; D005110:Extracellular Space / Q000032:analysis; D006651:Histocytochemistry; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D006916:5-Hydroxytryptophan