Lysine excretion by S-(2-aminoethyl)L-cysteine resistant mutants of Bacillus subtilis.
S-(2-Aminoethyl)L-cysteine (AEC) at 2 X 10(-1) mM concentration completely inhibited the growth of Bacillus subtilis. This inhibitory effect was readily reversed by 2 X 10(-2) mM L-lysine. Besides L-lysine, L-aspartic acid was only effective of all the natural amino acids tested in reversing the AEC-mediated growth inhibition. AEC resistant mutants of B. subtilis were isolated and found to excrete L-lysine in high yields.
D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D008239:Lysine / Q000378:metabolism* / Q000494:pharmacology; D009154:Mutation
C000204:S-2-aminoethyl cysteine; D008239:Lysine; D003545:Cysteine