The effect of the stable prostacyclin analogue ZK 36374 on experimental coronary thrombosis in the pig.
The hemodynamic and antithrombotic action of ZK 36374, a stable carbacyclin derivative of prostacyclin, was studied during electrically-induced coronary artery thrombosis in the open chest anesthetized pig. Infusion of ZK 36374 (100 ng/kg/min, n = 6) had no effect on heart rate and cardiac output, but caused a 20% reduction in mean arterial blood pressure by peripheral vasodilation. In animals receiving solvent or no drug prior to thrombosis induction, the time to occlusive coronary artery thrombosis (TOT) was 30 +/- 2 minutes (mean +/- SEM, n = 17). Pretreatment with an i.v. infusion of ZK 36374 (100 ng/kg/min) prolonged TOT by 50% to 47 +/- 7 minutes (p less than 0.005, n = 6). This prolongation of TOT was not due to the lower blood pressure in the ZK 36374 group, as dihydralazine in a dose that lowered arterial blood pressure to the same extent had no effect on TOT (32 +/- 4 minutes, n = 4). The results indicate that ZK 36374 may be useful in delaying (or preventing) occlusive coronary artery thrombi.
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology; D002316:Cardiotonic Agents / Q000494:pharmacology; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D004195:Disease Models, Animal; D011464:Epoprostenol / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D016285:Iloprost; D010974:Platelet Aggregation / Q000187:drug effects; D013552:Swine
D002316:Cardiotonic Agents; D005343:Fibrinolytic Agents; D011464:Epoprostenol; D016285:Iloprost