title: Neuron-glia adhesion is inhibited by antibodies to neural determinants.
abstract: Suspensions of embryonic chick neuronal cells adhered to monolayers of glial cells, but few neurons bound to control monolayers of fibroblastic cells from meninges or skin. Neuronal cell-glial cell adhesion was inhibited by prior incubation of the neurons with Fab' fragments of antibodies to neuronal membranes. In contrast, antibodies to the neural cell adhesion molecule (N-CAM) did not inhibit the binding. These results suggest that a specific adhesive mechanism between neurons and glial cells exists and that it is mediated by CAM's that differ from those so far identified.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D002448:Cell Adhesion; D002462:Cell Membrane / Q000276:immunology; D002478:Cells, Cultured; D002642:Chick Embryo; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000276:immunology / Q000502:physiology*
chemical_list: D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments