An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin.
Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D003429:Cross Reactions; D004527:Egg Proteins / Q000276:immunology*; D000939:Epitopes / Q000032:analysis; D051379:Mice; D010774:Phosvitin / Q000276:immunology*; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000276:immunology*; D014101:Torpedo
D000911:Antibodies, Monoclonal; D004527:Egg Proteins; D000939:Epitopes; D011950:Receptors, Cholinergic; D010774:Phosvitin