Poly ICL-CM dextran: an interferon inducer of reduced toxicity.
We have prepared soluble complexes of poly ICL-CM dextran that are as effective interferon IFN inducers, in mice and in rhesus monkeys, as poly ICLC. Toxicity testing was carried out in mice and, poly ICL-CM dextran is less toxic, in mice, than poly ICLC is.
D000818:Animals; D003911:Dextrans / Q000633:toxicity*; D007369:Interferon Inducers / Q000633:toxicity*; D008253:Macaca mulatta; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000633:toxicity*; D011070:Poly I-C / Q000633:toxicity*; D011107:Polylysine / Q000633:toxicity*; D012995:Solubility; D013045:Species Specificity; D013329:Structure-Activity Relationship
D003911:Dextrans; D007369:Interferon Inducers; D010455:Peptides; D011107:Polylysine; C042359:poly IC-polylysine carboxymethyl dextran; D011070:Poly I-C