T lymphocyte lines induce autoimmune encephalomyelitis, delayed hypersensitivity and bystander encephalitis or arthritis.
Lines of rat T lymphocytes responsive to the basic protein of myelin (BP) or to the purified protein derivative of Mycobacterium tuberculosis (PPD) were inoculated i.v. into recipient rats. As reported previously, the anti-BP line cells, but not the anti-PPD line cells spontaneously accumulated in the central nervous system and caused encephalomyelitis. However, the anti-PPD line cells could be induced to enter the brain and cause bystander encephalitis by intracerebral inoculation of PPD. Anti-PPD or anti-BP line cells could mediate delayed-type hypersensitivity skin reactions or bystander arthritis elicited by specific antigen. The lines did not cause specific cytolysis in vitro. Susceptibility to delayed-type hypersensitivity or bystander disease was long lasting in rats inoculated with anti-PPD line cells, while rats inoculated with anti-BP line cells were susceptible for only a few days. Thus, lines of T lymphocytes can mediate a variety of pathological reactions directed by the presence of specific antigen, self or foreign.
D000818:Animals; D001168:Arthritis / Q000209:etiology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D003876:Dermatitis, Atopic / Q000209:etiology*; D004660:Encephalitis / Q000209:etiology*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology* / Q000276:immunology; D005260:Female; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D007271:Injections, Intradermal; D008264:Macrophages / Q000276:immunology; D008297:Male; D004676:Myelin Basic Protein / Q000008:administration & dosage; D051381:Rats; D011917:Rats, Inbred Lew; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014373:Tuberculin / Q000008:administration & dosage
D004676:Myelin Basic Protein; D014373:Tuberculin