The effect of cysteamine on immunoreactive somatostatin in the rabbit retina.
Cysteamine hydrochloride was administered to rabbits at doses ranging from 0.3 to 10 mg by two intravitreal injections 24 h apart. Retinal immunoreactive somatostatin concentrations were reduced by about 50% at 24 h following the second injection. At doses of 0.3-3 mg, there was no demonstrable effect on retinal concentrations of immunoreactive substance P or of dopamine. Ten milligrams of cysteamine produced non-specific retinal damage. Cysteamine injected locally into the retina is a relatively specific drug for depletion of somatostatin.
D000818:Animals; D003543:Cysteamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D010455:Peptides / Q000378:metabolism*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism
D010455:Peptides; C029993:somatostatin-like peptides; D013373:Substance P; D013004:Somatostatin; D003543:Cysteamine; D004298:Dopamine