CSF neurochemistry of women with anorexia nervosa and normal women.
CSF tyrosine, tryptophan, 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), gamma-aminobutyric acid, choline, and calcium were compared in 33 anorexic and 14 normal women. The only significant difference between groups was a lower tyrosine level in the anorexic patients; their MHPG level was nonsignificantly higher. No significant group differences in body weight or depressive subgroup were found. HVA levels were positively related to body weight, and choline was negatively correlated with anorexia severity. The role of tyrosine requires further research, but these findings do suggest that HVA and choline increase with some recovery measures and MHPG is increased with this illness.
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000134:cerebrospinal fluid* / Q000150:complications; D001835:Body Weight; D002118:Calcium / Q000134:cerebrospinal fluid; D002794:Choline / Q000134:cerebrospinal fluid; D003866:Depressive Disorder / Q000134:cerebrospinal fluid / Q000150:complications; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D014364:Tryptophan / Q000134:cerebrospinal fluid; D014443:Tyrosine / Q000134:cerebrospinal fluid*; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid
D010648:Phenylacetates; D014443:Tyrosine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D005680:gamma-Aminobutyric Acid; D014364:Tryptophan; D002794:Choline; D002118:Calcium; D006719:Homovanillic Acid