65Zinc absorption in untreated and D-penicillamine-treated patients with generalized scleroderma: determination by whole-body counting technique.
65Zinc absorption in patients suffering from generalized scleroderma was studied by means of whole-body counting technique following a single dose of 65Zn. In 4 untreated patients the mean 65Zn absorption was calculated to 35% (range 20-59%). Five patients receiving oral D-penicillamine had a numerically higher mean absorption value of 55% (range 37-74%). The results corroborate earlier studies on the effect of D-penicillamine on 65Zn absorption in rats.
D000284:Administration, Oral; D006801:Humans; D010396:Penicillamine / Q000008:administration & dosage / Q000627:therapeutic use*; D012595:Scleroderma, Systemic / Q000188:drug therapy* / Q000378:metabolism; D014915:Whole-Body Counting; D015037:Zinc Radioisotopes / Q000378:metabolism*
D015037:Zinc Radioisotopes; D010396:Penicillamine