Platelet malondialdehyde and plasma thromboxane B2 formation in patients with obliterative arteriosclerosis of the lower limbs.
The platelet MDA and plasma TXB2 formation was studied in normal subjects and in patients with obliterative arteriosclerosis of the lower limbs. The increase in platelet MDA and plasma TXB2 formation could be found in these patients. It is concluded that these factors as well as the decrease in plasma cAMP level previously reported may play decisive role in the pathogenesis of occlusive arterial disease.
D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000097:blood*; D001792:Blood Platelets / Q000032:analysis*; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D013929:Thromboxane B2 / Q000096:biosynthesis* / Q000097:blood; D013931:Thromboxanes / Q000096:biosynthesis*
D008314:Malonates; D013931:Thromboxanes; D008315:Malondialdehyde; D013929:Thromboxane B2; D000242:Cyclic AMP