The influence of limonene on induced delayed hypersensitivity to citral in guinea pigs. II. Label distribution in the skin of 14C-labelled citral.
14C-labelled citral was applied on four groups of guinea pigs: (a) one sensitized to citral alone; (b) one sensitized to a citral-d-limonene 1 : 1 molar mixture; (c) FCA-treated controls; (d) controls. The most important results concern the amount of labelled material in soluble compared with insoluble skin protein extracts (SPE). In citral-sensitized animals, more label was found in the soluble SPE when citral + limonene was applied to the skin; in citral + limonene sensitized animals, the same trend (i.e. more label in soluble SPE) was found. The possible role of limonene in alleviating the allergic reaction to citral is discussed.
D000080462:Acyclic Monoterpenes; D000818:Animals; D002250:Carbon Radioisotopes; D053138:Cyclohexenes; D005243:Feces / Q000032:analysis; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D000077222:Limonene; D039821:Monoterpenes; D012867:Skin / Q000378:metabolism*; D013729:Terpenes / Q000009:adverse effects* / Q000032:analysis / Q000494:pharmacology* / Q000652:urine; D014018:Tissue Distribution; D014801:Vitamin A / Q000037:antagonists & inhibitors*
D000080462:Acyclic Monoterpenes; D002250:Carbon Radioisotopes; D053138:Cyclohexenes; D039821:Monoterpenes; D013729:Terpenes; D014801:Vitamin A; D000077222:Limonene; C007076:citral