The influence of some pteridines on pineal 5-methoxyindole synthesis in male Wistar rats periodically exposed to either white or green light.
The pineals of 28 days old male Wistar rats, in December periodically exposed to either white or green light, were incubated with pterin-6-aldehyde or reduced neopterin. In white light the rhythm of synthesis of 5-methoxytryptophan and of 5-methoxyindole-3-acetic acid was clearly influenced by the pteridines mentioned. In green light a change in rhythmicity of 5-methoxytryptophan, 5-methoxytryptamine and of melatonin/5-methoxytryptophol synthesis by the pteridines was observed. In white light both pteridines increased 5-methoxytryptophan and decreased 5-methoxyindole-3-acetic acid synthesis. Reduced neopterin stimulated 5-methoxytryptamine synthesis and inhibited melatonin/5-methoxytryptophol synthesis. Pterin-6-aldehyde showed an opposite effect. In green light both pteridines decreased 5-methoxytryptophan synthesis, but increased 5-methoxyindole-3-acetic acid and 5-methoxytryptamine synthesis. Melatonin/5-methoxytryptophol synthesis was decreased by reduced neopterin and increased by pterin-6-aldehyde. The results suggest an indolic metabolic pathway leading from 5-methoxytryptophan via 5-methoxytryptamine to melatonin, while pteridines and light of different wave lengths are correlated in regulating indole metabolism.
D008735:5-Methoxytryptamine / Q000096:biosynthesis; D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives / Q000096:biosynthesis; D007211:Indoles / Q000096:biosynthesis*; D008027:Light; D008297:Male; D008543:Melanins / Q000096:biosynthesis; D019798:Neopterin; D010870:Pineal Gland / Q000378:metabolism*; D011621:Pteridines / Q000494:pharmacology*; D011622:Pterins; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000031:analogs & derivatives / Q000096:biosynthesis
D007211:Indoles; D008543:Melanins; D011621:Pteridines; D011622:Pterins; D001708:Biopterins; C027986:5-methoxytryptophan; C001736:5-methoxyindoleacetic acid; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid; D019798:Neopterin; C002465:methoxytryptophol; C005926:2-amino-4-hydroxy-6-formylpteridine; D014364:Tryptophan