title: Effectiveness of various therapeutic regimens for bovine brucellosis.
abstract: Various chemotherapeutic regimens were evaluated in 48 culture-positive dairy cows. Cessation of shedding of Brucella abortus from udder secretions and absence in selected tissues at necropsy were criteria of success. A combination of a long-acting oxytetracycline and streptomycin eliminated Brucella in 10 of 14 (71.4%) cows. Two cows that were retreated with the same regimen also became culture-negative. Other treatment regimens, including the use of liposome-encapsulated antibiotics, were less successful. Serotests were a poor criterion of effectiveness.
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D002007:Brucellosis, Bovine / Q000188:drug therapy*; D002417:Cattle; D003959:Diamines / Q000627:therapeutic use; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D008081:Liposomes / Q000008:administration & dosage; D010118:Oxytetracycline / Q000008:administration & dosage* / Q000627:therapeutic use; D013307:Streptomycin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D003959:Diamines; D004338:Drug Combinations; D008081:Liposomes; C006270:avridine; D004096:Dihydrostreptomycin Sulfate; D010118:Oxytetracycline; D013307:Streptomycin