title: [Behavior of the hypothalamo-hypophyseal axis in a patient with asymmetric mixed gonadal dysgenesis (chromosome pattern 45,XO/46,XY) before and after gonad excision after with arginine, GRH and TRH stimulation].
abstract: In a 12 years old patient with asymmetric mixed gonadal dysgenesis (karyotype 45, XO/46,XY) a stimulation test with arginine, gonadotropin-releasing hormone (GRH) and thyreotropin-releasing hormone (TRH) was performed before and after exstirpation of the gonads as well as after application of sex steroids. FSH, LH, PRL, HGH, TSH, testosterone and oestradiol were determined by radioimmunoassay. The results show an intact hypothalamo-pituitary axis which reacts with a normal negative feedback with respect to the secretion of gonadotropins after application of sex steroids.
mesh_terms: D001120:Arginine; D002648:Child; D002715:Chlormadinone Acetate / Q000627:therapeutic use; D005260:Female; D006059:Gonadal Dysgenesis / Q000503:physiopathology*; D006061:Gonadal Dysgenesis, 46,XY / Q000188:drug therapy / Q000503:physiopathology*; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008656:Mestranol / Q000627:therapeutic use; D013973:Thyrotropin-Releasing Hormone
chemical_list: D002715:Chlormadinone Acetate; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D001120:Arginine; D008656:Mestranol
vernacular_title: Verhalten der hypothalamisch-hypophysären Achse bei einer Patientin mit asymmetrisch gemischter Gonadendysgenesie (Chromosomenmuster 45, XO/46, XY) vor und nach der Gonadenexstirpation auf die Stimulation mit Arginin, GRH und TRH.