[Thermogenic shivering in the anesthetized rat].
In normal pentobarbital-anaesthetized rats (20 mg/kg, i.p.), Ketanserine (2.5 to 10 mg/kg, i.v.) increases the temperature of the paw skin and decreases the central one. A strong thermogenetic shivering appears when central temperature falls below 35 degrees C. This shivering is a specific characteristics of Ketanserine activity, probably related to its fixation on 5-HT2 central receptors.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D007650:Ketanserin; D010424:Pentobarbital / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D012768:Shivering / Q000187:drug effects*
D010880:Piperidines; D007650:Ketanserin; D010424:Pentobarbital
Frisson thermogénétique chez le rat anesthésté.