Establishment of T cell hybridomas which produce suppressor factors specific to the hen egg-white lysozyme (HEL).
The T cell hybridoma (#5104-2) which produces a suppressor factor to suppress the hen egg-white lysozyme (HEL) specific T cell proliferative response in an antigen specific manner was developed in our laboratories. Suppression by this suppressor factor require an I-J subregion matching between suppressor factor donor and donor of HEL-specific proliferative T cells. The Igh restriction between this suppressor factor donor and HEL-primed responder cell donor has not yet been observed in our experimental system. This suppressor factor has binding activity to HEL and is bound to anti-I-J antibody columns. It was also found to suppress the HEL specific delayed type hypersensitivity (DTH) responses when administered at the induction phase.
D000818:Animals; D002645:Chickens; D000939:Epitopes / Q000276:immunology; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000276:immunology; D006825:Hybridomas / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis*; D051379:Mice; D009113:Muramidase / Q000276:immunology* / Q000494:pharmacology; D010063:Ovum / Q000201:enzymology; D013491:Suppressor Factors, Immunologic; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D006183:H-2 Antigens; D008222:Lymphokines; D013491:Suppressor Factors, Immunologic; D009113:Muramidase