Immunogenic and antigenic epitopes of immunoglobulins--V. Reactivity of a panel of monoclonal antibodies with sub-fragments of human Fc gamma and abnormal paraproteins having deletions.
The specificity of a panel of 27 monoclonal antibodies reactive with human Fc gamma has been further defined through reactivity profiles with sub-fragments of Fc gamma and IgG paraproteins having deletions within C gamma 2 or C gamma 3. Antibodies are identified that are directed to discontinuous epitopes requiring native Fc gamma for expression. Other antibodies are reactive with isolated C gamma 2 or C gamma 3 domains. Sub-class specific and sub-class restricted antibodies allow correlation of epitope expression with primary structure.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000276:immunology*; D006386:Hemagglutination Tests; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007142:Immunoglobulin gamma-Chains / Q000276:immunology; D051379:Mice; D008968:Molecular Conformation; D010266:Paraproteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007142:Immunoglobulin gamma-Chains; D010266:Paraproteins