title: Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line.
mesh_terms: D000818:Animals; D004351:Drug Resistance; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000032:analysis*; D007527:Isoenzymes / Q000096:biosynthesis*; D007940:Leukemia L5178 / Q000201:enzymology*; D007942:Leukemia, Experimental / Q000201:enzymology*; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis* / Q000276:immunology
chemical_list: D000939:Epitopes; D007527:Isoenzymes; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate