Hypomyelination in the cerebrum of the congenitally hypothyroid mouse (hyt).
2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in the cerebrum of the inherited primary hypothyroid mouse (hyt/hyt) is reduced in comparison with the normal heterozygate (hyt/+). No differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the hypothyroid mouse is restricted to the cerebrum, and is not related to arrested glial proliferation.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000473:pathology; D004247:DNA / Q000032:analysis; D007037:Hypothyroidism / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D009186:Myelin Sheath / Q000201:enzymology* / Q000648:ultrastructure; D009928:Organ Specificity; D012313:RNA / Q000032:analysis
D012313:RNA; D004247:DNA; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases