[Choleragen-anatoxin chemical cholera vaccine enriched with Ogawa O-antigen].
The cultural fluid of Vibrio cholerae strains of serovar Ogawa, grown under the conditions of submerged cultivation, has been shown to contain a large amount of soluble O-antigen which sharply differs from all other concomitant components in its molecular weight. By enriching the commercial chemical cholera vaccine known as Choleragen Toxoid with purified Ogawa O-antigen a new preparation, consisting mainly of cholera toxoid and Ogawa and Inaba O-antigens and capable of producing pronounced immunity to V. cholerae of both serovars, has been obtained.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000276:immunology* / Q000302:isolation & purification / Q000633:toxicity; D000992:Antitoxins / Q000032:analysis; D001428:Bacterial Vaccines / Q000276:immunology* / Q000302:isolation & purification / Q000633:toxicity; D002772:Cholera Toxin / Q000276:immunology* / Q000302:isolation & purification / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008970:Molecular Weight; D019081:O Antigens; D012995:Solubility; D014734:Vibrio cholerae / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000992:Antitoxins; D001428:Bacterial Vaccines; D019081:O Antigens; D002772:Cholera Toxin
Izuchenie kholernoĭ khimicheskoĭ vaktsiny "kholerogen-anatoksin", obogashchennoĭ O-antigenom Ogava.