title: [Peptidergic innervation of the cerebral blood vessels--an immunohistochemical study].
abstract: By an immunohistochemical technique, vasoactive polypeptide (VIP)-and substance P-containing nerve fibers are observed in the cerebral blood vessels. VIP-containing nerve fibers distribute in a spiral pattern, similar to the muscle cell distribution pattern. Under an electron microscopic observation, VIP-immunoreactive terminals lie just near to a muscle cell in the inner layer of the adventitia. In contrast, substance P-containing nerve fibers show a meshwork pattern in the outer layer of the adventitia. In combination of acetylcholinesterase (AChE) staining and VIP immunohistochemistry, AChE-positive and VIP-immunoreactive nerve fibers reveal almost same distribution in the same specimen. The present data suggest that VIP-containing nerve fibers may play a role of smooth muscle control of the blood vessels, while substance P-containing nerve fibers may not take part in muscle control.
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D001923:Brain Chemistry; D002536:Cerebral Arteries / Q000032:analysis / Q000648:ultrastructure; D006168:Guinea Pigs; D006651:Histocytochemistry; D009412:Nerve Fibers / Q000032:analysis; D013194:Staining and Labeling; D013373:Substance P / Q000032:analysis*; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
chemical_list: D013373:Substance P; D014660:Vasoactive Intestinal Peptide