Antiproliferative action of interferon on murine bone-marrow derived macrophages is influence by the genotype of the marrow-donor.
Mouse interferon inhibits proliferation of bone-marrow derived macrophages. The degree of inhibition of cell proliferation is significant influenced by the genotype of the bone marrow donor in that C57BL/6 cells are more resistant to the cell multiplication inhibitory effect of interferon than are BALB/c cells. These results thus confirm earlier observations using murine erythroid precursors as target cells and point to the existence of genes modulating the action of interferon.
D000818:Animals; D001854:Bone Marrow Cells; D002455:Cell Division; D003114:Colony-Forming Units Assay; D005838:Genotype; D006183:H-2 Antigens / Q000276:immunology; D007372:Interferons / Q000494:pharmacology*; D008264:Macrophages / Q000166:cytology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
D006183:H-2 Antigens; D007372:Interferons