Interferon with novel characteristics produced by human mononuclear leukocytes.
Treatment of human peripheral blood mononuclear leukocytes with phytohaemmaglutinin and the tumour promoter teleocidin, results in the production of large amounts of interferon-gamma and significant amounts of a novel interferon-like substance which we tentatively class as interferon-delta. This novel interferon type possesses all the important characteristics of classical interferon but, of various cell types tested, has antiviral activity only in trisomy-21 human fibroblasts. It differs decisively from previously identified interferon types in its antigenic, biological and physicochemical properties.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D002846:Chromatography, Affinity; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007370:Interferon Type I / Q000097:blood*; D051379:Mice; D008970:Molecular Weight; D009000:Monocytes / Q000032:analysis*
D000939:Epitopes; D007370:Interferon Type I; C037655:interferon, delta