Lithium modulates mitogen induced natural killer activity and interferon production.
Incubation of human peripheral blood mononuclear cells with lithium ions in combination with either phytohemagglutinin or concanavalin A resulted in increased natural killer cell activity. Maximum augmentation was observed following three days of culturing peripheral blood mononuclear cells with mitogens and lithium and was accompanied by increased interferon production. Lithium did not enhance the natural killer cell activity of peripheral blood mononuclear cells cultured with Poly I:C.
D000242:Cyclic AMP / Q000032:analysis; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology*; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology
D008934:Mitogens; D010835:Phytohemagglutinins; D007372:Interferons; D008094:Lithium; D000242:Cyclic AMP