Allotypic determinants (Igh-3) associated with the IgG2c subclass of rat immunoglobulins.
Rat antibodies to group A streptococcal carbohydrate are primarily of the IgM and IgG isotypes. Hyperimmunization often results in antibodies of a restricted molecular heterogeneity of the IgG2c isotype. An allotypic marker, designated Igh-3a, was detected on the heavy chains of the IgG2c isotype from Copenhagen rats. Igh-3b was detected on the heavy chains of IgG2c from SHR rats. A strain distribution of the Igh-3 determinants as well as inheritance patterns for their expression are presented.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005786:Gene Expression Regulation; D007106:Immune Sera / Q000276:immunology; D007126:Immunoglobulin Allotypes / Q000235:genetics / Q000276:immunology*; D007074:Immunoglobulin G / Q000235:genetics / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000942:Antigens, Bacterial; D000939:Epitopes; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D011135:Polysaccharides, Bacterial; C036112:streptococcal polysaccharide group A