[The effect of vaporization with thermal sulfurous water on phospholipids in the broncho-alveolar lavage solution following hypobaric hypoxia in the rat].
We have studied, in the rat, the action of a vaporization with sulphurous water from Bagnères de Luchon on the surfactant modifications caused by hypoxia. The phospholipase activity, subordinate to hypoxia, decreased by 1/5 compared to its value without treatment and the phospholipid composition of the broncho-alveolar lung lavage remained unchanged whereas after hypoxia without treatment the phosphatidylcholines level decreases by 26%. We demonstrated by a dose-response study that this protective action decreased with the thermal water dilution. We also showed that this effect could not be due to the only action of reduced sulphur: different concentrations of sulphur solutions had no action on the phospholipase A activity subordinate to hypoxia. So we can conclude that a vaporization with sulphurous water had a protective action against hypoxia on the broncho-alveolar lavage of rat lung.
D000532:Altitude Sickness / Q000378:metabolism*; D000818:Animals; D001980:Bronchi / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D008900:Mineral Waters; D010743:Phospholipids / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000378:metabolism*; D011663:Pulmonary Surfactants / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013455:Sulfur / Q000494:pharmacology*; D013997:Time Factors
D008900:Mineral Waters; D010743:Phospholipids; D011663:Pulmonary Surfactants; D013455:Sulfur
Effet d'une vaporisation d'eau thermale sulfureuse sur les phospholipides du liquide de lavage broncho-alvéolaire après hypoxie hypobare chez le rat.