Demonstration of tissue-specific antigens shared by normal pancreas and pancreatic neoplasms.
Xenoantiserum raised against extracts of normal hamster pancreas, after absorption with normal tissues, reacted specifically with normal hamster and human pancreas by immunodiffusion. Absorbed antiserum also reacted with hamster and human pancreatic carcinoma but not with other neoplasms. Immunization of hamsters with normal pancreas extracts prevented growth of transplantable pancreatic carcinomas.
D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D006224:Cricetinae; D000939:Epitopes / Q000276:immunology*; D006651:Histocytochemistry; D006801:Humans; D007114:Immunization; D005779:Immunodiffusion; D007124:Immunoenzyme Techniques; D008297:Male; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D010179:Pancreas / Q000276:immunology*; D010190:Pancreatic Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D000939:Epitopes