title: Delayed cerebral development in twins with congenital hyperthyroidism.
abstract: Twins had congenital hyperthyroidism and delayed cerebral development manifested as ventriculomegaly, increased space in the interhemispheric fissure, and an exaggerated gyral pattern on cranial computed tomographic scans. At 3 1/2 years of age, both children had delayed development. Fetal and neonatal hyperthyroidism may interfere with normal brain growth and maturation with both neuranatomic and developmental sequelae.
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000254:growth & development*; D002552:Cerebral Ventricles / Q000473:pathology; D014695:Cerebral Ventriculography; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology*; D004200:Diseases in Twins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000151:congenital*; D007223:Infant; D007231:Infant, Newborn; D013997:Time Factors; D014057:Tomography, X-Ray Computed