Antigen specificity and helper characteristics of antigen-driven helper-cell-independent cytolytic T lymphocytes.
Antigen-driven, helper-cell-independent cytolytic T lymphocytes, which proliferate in response to antigenic stimulation independently of exogenous lymphokines, were characterized with regard to antigen specificity and helper factor production. Mapping data indicate that the determinants recognized by such cells for cytotoxicity and proliferation induction are identical. In addition, the cells were shown to function like helper cells in that they secrete soluble IL-2-like factor upon stimulation with the sensitizing antigens. The potential importance of this cell type in the immune response is discussed.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D002999:Clone Cells / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000941:Antigens; D000939:Epitopes; D008222:Lymphokines