Antithrombic activity of some polysaccharide resins.
Crosslinked dextrans (Sephadex) bearing essentially carboxymethyl, benzylsulphonate and alpha-amino acid groups have been synthesized. The antithrombic activity of the resins may be the result of a cooperative effect between the functional groups. The binding of benzylsulphonate to carboxymethylated Sephadex endows these materials with activity. However the highest activity is obtained when the resins contain simultaneously benzylsulphonate, alpha-amino acid and carboxylic acid groups.
D000925:Anticoagulants; D001777:Blood Coagulation / Q000187:drug effects*; D003911:Dextrans / Q000138:chemical synthesis / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D013329:Structure-Activity Relationship; D013918:Thrombin Time
D000925:Anticoagulants; D003911:Dextrans; D006493:Heparin