Fatal complement-induced leukostasis after diatrizoate injection. Principles of clinicopathologic diagnosis.
A case of fatal radiographic contrast medium (RCM)-induced pulmonary granulocyte aggregation (leukostasis) showed massive elevation of the postmortem histamine level. Suspicion of this phenomenon in diverse clinical settings permits clinical and pathological documentation via increased plasma levels of C3a and other means. The existence of effective prophylaxis stimulates a search for predictive tests.
D000368:Aged; D002449:Cell Aggregation / Q000187:drug effects; D003176:Complement C3 / Q000378:metabolism*; D015926:Complement C3a; D003170:Complement Pathway, Alternative / Q000187:drug effects; D003645:Death, Sudden / Q000209:etiology; D003973:Diatrizoate / Q000009:adverse effects*; D005260:Female; D006098:Granulocytes / Q000473:pathology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000276:immunology; D011652:Pulmonary Circulation / Q000187:drug effects
D003176:Complement C3; D003973:Diatrizoate; D015926:Complement C3a