title: Development of a new tachykinin antagonist.
abstract: The mouse urinary bladder possesses a tachykinin receptor which responds to kassinin and eledoisin, but not to some other tachykinins. The action of kassinin, but not that of eledoisin, was blocked in a surmountable manner by a new tachykinin antagonist, D-Pro4, Val8, D-Trp (SP).
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004600:Eledoisin / Q000494:pharmacology; D066298:In Vitro Techniques; D015286:Kassinin; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009842:Oligopeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010455:Peptides / Q000037:antagonists & inhibitors*; D013373:Substance P / Q000494:pharmacology; D015320:Tachykinins; D001743:Urinary Bladder / Q000502:physiology*
chemical_list: D009842:Oligopeptides; D010455:Peptides; D015320:Tachykinins; D013373:Substance P; D015286:Kassinin; D004600:Eledoisin