Galactose tolerance test and methotrexate-induced liver fibrosis and cirrhosis in patients with psoriasis.
A total of 151 galactose tolerance tests (GTT) and liver biopsies were performed in a consecutive study of 45 psoriatic patients with methotrexate-induced liver fibrosis; of these, 23 had cirrhosis. Most patients with an abnormal liver histology had a normal GTT. We conclude that an oral GTT is not sensitive enough to reveal methotrexate-induced liver fibrosis or cirrhosis. The results indicate that the histological changes in methotrexate-induced liver fibrosis and cirrhosis may be of a rather non-aggressive nature.
D000284:Administration, Oral; D001706:Biopsy; D004361:Drug Tolerance; D005690:Galactose / Q000008:administration & dosage / Q000652:urine; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced*; D008727:Methotrexate / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy*
D005690:Galactose; D008727:Methotrexate