title: [Alkaline phosphatase and transketolase activity during immunogenesis in the lymphoid organs of rats with vitamin B1 deficiency caused by oxythiamine].
abstract: A study was made of the effect of different doses of hydroxythiamine on activity of alkaline phosphatase and transketolase in rat spleen and thymus during primary and secondary administration of human gamma-globulin. Immunization of rats significantly raised alkaline phosphatase activity in both organs. Administration of a large single dose of hydroxythiamine (400 mg/kg bw) reduced transketolase activity in the thymus and spleen in both immunized and non-immunized animals and did not change alkaline phosphatase activity in these organs.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D007114:Immunization; D008221:Lymphoid Tissue / Q000201:enzymology* / Q000276:immunology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010119:Oxythiamine / Q000276:immunology*; D051381:Rats; D013832:Thiamine Deficiency / Q000139:chemically induced / Q000201:enzymology* / Q000276:immunology; D013844:Thiazoles / Q000276:immunology*; D013997:Time Factors; D014174:Transketolase / Q000378:metabolism*; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D013844:Thiazoles; D005719:gamma-Globulins; D010119:Oxythiamine; D014174:Transketolase; D000469:Alkaline Phosphatase
vernacular_title: Aktivnsot' shchelochnoĭ fosfatazy i transketolazy v limfoidnykh organakh krys s nedostatochnost'iu vitamina B1, vyzvannoĭ oksitiaminom, pri immunogeneze.