Production of human chorionic gonadotrophin by a hepatoblastoma resulting in precocious puberty.
A two year old boy presented with precocious puberty associated with hepatoblastoma. Serum concentrations of beta human chorionic gonadotrophin and alpha-fetoprotein were raised. An aggressive chemotherapeutic regimen resulted in useful palliation and interesting changes in the beta human chorionic gonadotrophin and alpha-fetoprotein concentrations. In contrast to a previous report, the ultrastructure of the tumour showed frequent Golgi apparatus but no other electron dense membrane bound vesicles.
D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000150:complications* / Q000648:ultrastructure; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications* / Q000648:ultrastructure; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D011629:Puberty, Precocious / Q000209:etiology*; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D000509:alpha-Fetoproteins