Actions of neurotransmitters and peptides on longitudinal and circular muscle of the rat portal vein.
The reactivity of longitudinal and circular muscle of the rat portal vein to noradrenaline, acetylcholine, 5-hydroxytryptamine, substance P, angiotensin II and neurotensin was compared. Longitudinal muscle was prepared as longitudinal strips and circular muscle was studied as transversally cut rings. Longitudinal muscle was more sensitive than circular muscle to acetylcholine, 5-hydroxytryptamine and angiotensin II, whereas both muscle layers were equally sensitive to noradrenaline and substance P. Circular muscle was generally unresponsive to neurotensin. Differential sensitivity of longitudinal and circular muscle layers suggests that these two muscle layers do not necessarily operate in unison.
D000109:Acetylcholine / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011169:Portal Vein / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology
D018377:Neurotransmitter Agents; D010455:Peptides; D000804:Angiotensin II; D012701:Serotonin; D013373:Substance P; D000109:Acetylcholine; D009638:Norepinephrine