The role of cell type in transport and metabolic conversion of antiviral substances.
The transport and metabolic conversion of 6-azauridine differed when compared in HeLa and chick embryo (CE) cells. The values of 9-(S)-(2, 3-dihydroxypropyl) adenine transported into the cells were found different for ZP cells (rabbit lung cell line), HeLa and CE cells. These differences were less expressed if relating the values of cellular uptake and metabolic conversion to the cell volume of the respective cell type. The differences seem to play a role in quantitation of the antiviral potency of the compounds in different host cells.
D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism; D001380:Azauridine / Q000378:metabolism*; D001692:Biological Transport; D001711:Biotransformation; D002642:Chick Embryo; D006367:HeLa Cells; D006801:Humans; D007739:L Cells; D051379:Mice; D014542:Uridine Monophosphate / Q000031:analogs & derivatives / Q000378:metabolism
D000998:Antiviral Agents; C011569:6-azauridine-5'-monophosphate; D001380:Azauridine; D014542:Uridine Monophosphate