Sertoli-Leydig cell tumor of the ovary producing alpha-fetoprotein.
A 16-year-old girl with virilization and elevated serum alpha-fetoprotein (AFP) levels was found to have a Sertoli-Leydig cell tumor of the ovary. Immunoperoxidase studies using anti-AFP localized AFP in cells with the histologic appearance of Leydig cells. Serum AFP fell to undetectable levels after excision of the tumor. The patient is alive and well 1 year postexcision.
D000152:Acne Vulgaris / Q000209:etiology; D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007984:Leydig Cell Tumor / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D010053:Ovary / Q000473:pathology; D012707:Sertoli Cell Tumor / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D014770:Virilism / Q000209:etiology; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins