Characterization of exogenous type D retrovirus from a fibroma of a macaque with simian AIDS and fibromatosis.
A novel type D retrovirus was isolated by cocultivation of explants of fibromatous tissue from a rhesus monkey (Macaca mulatta) with immunodeficiency and retroperitoneal fibromatosis. This type D virus, isolated from a macaque with simian acquired immunodeficiency syndrome (SAIDS-D/Washington), is exogenous and is partially related to the Mason-Pfizer and the langur monkey type D viruses. The SAiDS-D virus can be distinguished from all other primate retroviruses by antigenicity and molecular hybridization. Nucleic acid hybridization studies reveal that the origin of the SAIDS-D isolate may reside in Old World monkey (subfamily Colobinae) cellular DNA.
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001483:Base Sequence; D002520:Cercopithecidae / Q000235:genetics; D004279:DNA, Viral; D004195:Disease Models, Animal; D000939:Epitopes; D005350:Fibroma / Q000382:microbiology / Q000662:veterinary*; D008253:Macaca mulatta / Q000382:microbiology; D008992:Monkey Diseases / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D012186:Retroperitoneal Neoplasms / Q000382:microbiology / Q000662:veterinary*; D012190:Retroviridae / Q000145:classification / Q000302:isolation & purification* / Q000502:physiology; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology
D000956:Antigens, Viral; D004279:DNA, Viral; D000939:Epitopes; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins; D014764:Viral Proteins