Effects of peptides on gastric emptying.
The effects of peptides on gastric emptying of a liquid meal were studied in rats. Gastric emptying was found to be delayed following intraperitoneal injection of the octapeptide of cholecystokinin (CCK-8). Vasoactive intestinal peptide did not effect emptying, while substance P and neurotensin caused a moderate acceleration in gastric emptying. After oral administration of a solution containing the amino acids tryptophan and phenylalanine, but not glycine, a statistically significant inhibition of gastric emptying was observed. Our results suggest an involvement of CCK in the regulation of gastric emptying.
D000818:Animals; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D009496:Neurotensin / Q000494:pharmacology; D010649:Phenylalanine / Q000494:pharmacology; D051381:Rats; D012844:Sincalide / Q000494:pharmacology*; D013373:Substance P / Q000494:pharmacology; D014364:Tryptophan / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin; D010649:Phenylalanine; D014364:Tryptophan; D012844:Sincalide