title: Disulfiram implantation: a dose response trial.
abstract: Alcoholic volunteers (N = 120) were assigned at random to receive an 800 mg, 1200 mg, or 1600 mg subcutaneous disulfiram implant. Patients were followed for a 2-year period. Although all groups showed an increase in sobriety following implantation, there was no significant dose-response relationship. There were no significant between-group differences in the incidence of disulfiram-ethanol reaction.
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000437:Alcoholism / Q000534:rehabilitation*; D004221:Disulfiram / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005500:Follow-Up Studies; D006703:Ill-Housed Persons; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010349:Patient Compliance; D011788:Quality of Life; D012107:Research Design / Q000592:standards; D012737:Sex Factors; D013546:Sweating; D013610:Tachycardia / Q000139:chemically induced
chemical_list: D004343:Drug Implants; D000431:Ethanol; D004221:Disulfiram