[Complexes of nonionic triether analogs of oligonucleotides with polynucleotides].
Alkyl triester analogues of oligodeoxynucleotides were synthesized: [Tp(CH3)]8T(Ac), [Tp(C2H5)]8T, [dGp(C2H5)]2G, [dAp(C2H5)]2A. Their binding to complementary polyribo-and polydeoxyribonucleotides was studied by UV-spectroscopy and gel-filtration. The DNA complexes of analogues were shown to be more thermostable than the RNA ones independent on the nucleic base nature and alkyl residue size of the analogue used. Mg-salt increased the thermostability of the oligonucleotide analogue--RNA complexes.
D000478:Alkylation; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis; D009841:Oligonucleotides / Q000138:chemical synthesis; D011089:Polydeoxyribonucleotides; D012313:RNA; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D011089:Polydeoxyribonucleotides; D012313:RNA; D004247:DNA
Kompleksy neionnykh triéfirnykh analogov oligonukleotidov s polinukleotidami.