Alterations in leukocytes induced by virus and interferon.
Alterations occurring in cells under an influence of interferon or viral interferon inducer were observed under the fluorescence microscope. The experiments were carried out with human leukocytes stained intravitally with acridine orange. From our observations it follows that both interferon as well as interferon inducer evoke morphological changes in leukocytes causing partial or complete disappearance of lysosomes in cytoplasm.
D000165:Acridine Orange; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects; D010222:Parainfluenza Virus 1, Human / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology
D007370:Interferon Type I; D007372:Interferons; D000165:Acridine Orange