Fragments of myelin basic protein derived from human brain are not mitogenic in cultures of human amniotic fluid cells and other cells.
The possible mitogenic effects of a number of preparations of the myelin basic protein (MBP) of human brain have been investigated in various cell types in culture, including human amniotic fluid cells. Intact human MBP, as well as fragments derived by BNPS-skatole and cathepsin D treatment, and isoelectric focusing fractions of human MBP, showed no mitogenic activity. These results are consistent with recent findings that the fibroblast growth factor (FGF) activity of bovine brain does not originate from MBP.
D000653:Amniotic Fluid / Q000166:cytology*; D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D005260:Female; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006801:Humans; D007525:Isoelectric Focusing; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D004676:Myelin Basic Protein / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011247:Pregnancy
D004676:Myelin Basic Protein; D010446:Peptide Fragments; D005346:Fibroblast Growth Factors