title: Chronic granulocytic leukemia.
abstract: This article reviews the definition, etiology, epidemiology, cytogenetics, and diagnosis of chronic granulocytic leukemia (CGL). There is detailed consideration of clinical and laboratory findings, the natural history of CGL, and the selection of therapy at different stages of the disease. The roles of bone marrow transplantation and of newer experimental therapeutic approaches are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000627:therapeutic use; D002904:Chromosomes, Human, 21-22 and Y; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007937:Leukapheresis; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010166:Palliative Care; D011239:Prednisolone / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D013866:Thioguanine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D003561:Cytarabine; D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone; D001215:Asparaginase; D013866:Thioguanine; D002066:Busulfan; D011241:Prednisone; D006918:Hydroxyurea; D008727:Methotrexate; D003630:Daunorubicin