Studies of antigens in Plasmodium yoelii. I. Antigenic differences between parasite lines detected by crossed immunoelectrophoresis.
Antigens of three lines of the rodent malaria parasite Plasmodium yoelii have been studied using crossed immunoelectrophoresis. P. y. yoelii line A1 is a mild line which is restricted to reticulocytes. P. y. yoelii line YM and P. y. nigeriensis line D1 are virulent infections which multiply in both immature and mature erythrocytes. One antigen, designated Py-1, was found to differ in its electrophoretic mobility between the lines, being fast (F) in lines A1 and YM and slow (S) in line D1. Antigen Py-1 also varied in quantity among the three lines; greater amounts were detected in parasites inhabiting mature erythrocytes than in those in reticulocytes. These characters were stable during blood and mosquito passage.
D000740:Anemia / Q000469:parasitology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000939:Epitopes / Q000032:analysis* / Q000276:immunology; D004912:Erythrocytes / Q000469:parasitology; D007123:Immunoelectrophoresis, Two-Dimensional; D008288:Malaria / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D010961:Plasmodium / Q000276:immunology* / Q000472:pathogenicity; D012156:Reticulocytes / Q000469:parasitology; D014774:Virulence
D000911:Antibodies, Monoclonal; D000939:Epitopes