Dominant-lethal study of technical-grade hexachlorocyclohexane in Swiss mice.
Male Swiss mice, 6-8 weeks old, were given a diet containing technical-grade hexachlorocyclohexane (BHC) at 500 ppm continuously for 4, 6 and 8 months. After the completion of the scheduled exposure period, the males were sequentially mated with 2-3 untreated virgin females at weekly intervals for 8 weeks. The females were autopsied at mid-term pregnancy for evaluation of dominant-lethal mutation. The number of dead implants, including deciduomas and dead embryos, showed a significant increase. Similarly, the percentage fertility and live embryos per female showed a decline when compared with the control
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005313:Fetal Death; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D008297:Male; D051379:Mice; D009154:Mutation; D011247:Pregnancy
D001556:Hexachlorocyclohexane