Neural tissues express high levels of the cellular src gene product pp60c-src.
Chicken embryo tissues were examined for the expression of pp60c-src, the normal cellular homolog of the transforming protein of Rous sarcoma virus. Three assays, including a solid-phase radioimmunoassay, a competitive radioimmunoprecipitation assay, and an immune complex protein kinase assay, were employed. Elevated levels of pp60c-src were detected in lysates from several neural tissues, including brain, retina, and spinal ganglia. Other tissues contained 8- to 10-fold-lower levels of pp60c-src, levels comparable to those found in chicken embryo fibroblasts. Expression of pp60c-src in brain tissues was also shown to vary with the developmental stage of the embryo.
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D002642:Chick Embryo; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D015688:Oncogene Protein pp60(v-src); D019000:Phosphotyrosine; D011494:Protein Kinases / Q000378:metabolism; D014443:Tyrosine / Q000031:analogs & derivatives / Q000096:biosynthesis; D014764:Viral Proteins / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D014764:Viral Proteins; D019000:Phosphotyrosine; D014443:Tyrosine; D011494:Protein Kinases; D015688:Oncogene Protein pp60(v-src)