Anti-infectious properties of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79).
The anti-infectious activity of the C-79 preparation was examined on mice intravenously infected with Shigella sonnei dysentery of phase I. The activity of the preparation was determined taking into account the number of bacteria cultured from the organs of the examined animals and the number of animals surviving the infection as compared with the control. C-79 preparation administered to the mice before the infection was observed to protect then from death almost in 100%. The activity of the preparation differed according to the strategy of administration.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003300:Copper / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use*; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D005260:Female; D008099:Liver / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000382:microbiology
D000900:Anti-Bacterial Agents; D003911:Dextrans; C018905:dextran-2-hydroxy-3-mercaptopropyl ether; D003300:Copper