Loss of the PGE1 requirement for MDCK cell growth associated with a defect in cyclic AMP phosphodiesterase.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000527:Alprostadil; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003470:Culture Media; D000242:Cyclic AMP / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007668:Kidney; D007700:Kinetics; D009154:Mutation; D011458:Prostaglandins E / Q000494:pharmacology*
D003470:Culture Media; D011458:Prostaglandins E; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000527:Alprostadil; D015056:1-Methyl-3-isobutylxanthine