[Mucohistochemical studies of CEA producing and non-producing stomach cancers].
In this report, 141 patients with gastric cancer were studied histochemically. Tissue CEA was stained by the CEA-PAP method and the gastric cancer was classified into CEA-producing (96 cases, 68.1%) and CEA non-producing gastric cancer (45 cases, 31.9%). Histologically, CEA-producing gastric cancer was well differentiated adenocarcinoma and CEA non-producing gastric cancer was chiefly undifferentiated carcinoma. PAS, pH 2.5 Alcian-blue, High Iron Diamine, Alkaline-PAS, and Concanavalin A paradoxical stain were applied to specimens from each type of gastric carcinoma. Mucosubstances of CEA-producing gastric cancer were positive for A-B, HID, AL-PAS and CPS III-1; those of CEA non-producing gastric cancer were positive for PAS and CPS III-s, but negative for A-B, HID and A1-PAS. These results suggest that CEA-producing gastric cancer arises from intestinal metaplasia of gastric mucosa and that CEA non-producing gastric cancer arises from the gastric mucosa itself.
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000276:immunology / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000276:immunology / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005752:Gastric Mucins / Q000032:analysis; D006801:Humans; D009093:Mucus / Q000166:cytology*; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology
D002272:Carcinoembryonic Antigen; D005752:Gastric Mucins