Differential cytostatic effect of interferon on murine BALB/c B- and T-cell tumors.
The cytostatic effect of murine interferon (IFN) on several BALB/c-derived B- and T-cell tumor cells was examined. After incubation for 1 h in vitro with 1000 U of IFN, followed by intraperitoneal inoculation, tumor formation was not decreased in the case of B cell tumors or Lyt-1+2- or Lyt-1+2+3+ T cells tumors. Under the same conditions, the onset of tumor formation for Lyt-2+3+ T-cell tumors was delayed and the final incidence decreased. When the effect of IFN on cell multiplication in vitro was examined, Lyt-2+3+ T-tumor cells were found to be more sensitive to the cytostatic effect of IFN than Lyt-1+2+3+ T-tumor cells. This shows that the sensitivity of lymphocyte-derived tumor cells to the cytostatic effect of IFN is influenced by the type of differentiation of the cells.
D000818:Animals; D001402:B-Lymphocytes; D002454:Cell Differentiation / Q000187:drug effects*; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*; D013601:T-Lymphocytes
D007372:Interferons