T cell subsets and soluble immune response suppressor (SIRS) factor in skin squamous cell carcinoma.
T cell subsets (theophylline-sensitive T lymphocytes and T gamma lymphocytes), and the activity of soluble immune response suppressor (SIRS) factor have been investigated in a total of 53 patients with squamous cell carcinoma (SCC) of the skin. Eight of these had metastatic regional lymph nodes. The results showed decreased values for theophylline-sensitive T lymphocytes and elevated values for T gamma cells. Suppressor function evaluated by means of SIRS factor was normal in 36 patients with non-metastatic skin SCC and decreased in 8 with metastatic skin cancer.
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D005260:Female; D006801:Humans; D008048:Lip Neoplasms / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011961:Receptors, Fc / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology*; D013491:Suppressor Factors, Immunologic; D013601:T-Lymphocytes / Q000276:immunology*; D013806:Theophylline
D008222:Lymphokines; D011961:Receptors, Fc; D013491:Suppressor Factors, Immunologic; C013256:soluble immune response suppressor; D013806:Theophylline