Methisoprinol effect on enriched B and T lymphocyte populations stimulated with phytohemagglutinin.
The Authors investigated the effect of methisoprinol (Inosiplex) on separated B and T lymphocytes from 8 healthy donors. B or T treated cells, recombined with T or B untreated cells, were subsequently mitogen stimulated. Proliferative response resulted significantly increased, in comparison to a control, when T lymphocytes were preincubated with the drug, while treating only B lymphocytes led to a decrement. These data confirm the hypothesis of a direct action of the drug on T lymphocytes, but are also consistent with its influence on B cells too, even though with an opposite effect.
D000328:Adult; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D066298:In Vitro Techniques; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects*
D010835:Phytohemagglutinins; D011947:Receptors, Antigen, B-Cell; D007288:Inosine; D007542:Inosine Pranobex