[State of regenerative processes in the mucosa of the small intestine in celiac disease in adults (gluten enteropathy)].
Biopsies of the small intestine mucosa were studied in 60 patients among which celiac disease was diagnosed in 35 after clinico-morphological examinations and chronic enteritis in 25. Apart from histological and histochemical methods, autoradiography of biopsies with 3H-thymidine was used. The study showed that atrophy of the small intestine mucosa in celiac disease in adults was of hyperregeneratory nature which was manifested by deepening of the crypts and increased number of DNA-synthesizing enterocytes. Due to enhanced proliferation incompletely differentiated cells appear on the villae which are incapable of completely performing the functions of membrane digestion and absorption. These enterocytes are histochemically similar with crypt epithelium and, like the latter, are more stable to autolysis. Functionally, the presence on the villae of incompletely differentiated epithelium is more significant than villi atrophy. Treatment with aglutenic diet eliminates the syndrome of disturbed absorption despite persisting atrophy. The processes of cell renewal become normalized as proved by the appearance of high epithelium on the villae and decreased label index.
D000328:Adult; D001284:Atrophy; D001706:Biopsy; D002446:Celiac Disease / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012313:RNA / Q000378:metabolism
D012313:RNA; D004247:DNA
Sostoianie protsessov regeneratsii slizistoĭ obolochki tonkoĭ kishki pri tseliakii vzroslykh (gliutenovoĭ énteropatii).