Degradation of rRNA in interferon-treated vaccinia virus-infected cells.
In interferon-treated mouse L cells, following infection with a DNA-containing virus, vaccinia, synthesis of unique 2'-5'-linked oligonucleotides of the general formula ppp5'A2'(p5'A)n, abbreviated as 2-5A, was detected by competition radiobinding assay. In addition, degradation of rRNA into discrete and characteristic products, similar to those produced by 2-5A-activated endonuclease, was observed. The degradation of rRNA may represent a significant component of antiviral action of interferon in vaccinia virus-infected cells.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D007372:Interferons / Q000494:pharmacology*; D007700:Kinetics; D007739:L Cells / Q000378:metabolism; D051379:Mice; D009843:Oligoribonucleotides / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects; D012335:RNA, Ribosomal / Q000378:metabolism*; D014616:Vaccinia virus / Q000187:drug effects / Q000235:genetics*
D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; D012335:RNA, Ribosomal; C023505:2',5'-oligoadenylate; D007372:Interferons