Induction of chromosome aberrations by chemical mutagens in neural ganglia of Drosophila melanogaster.
Chromatid aberrations induced by various concentrations of bleomycin, cyclophosphamide and mitomycin C were analyzed in neural ganglia of third-instar larvae of Drosophila melanogaster. A clear dose response was observed with increasing dose after treatment with bleomycin and mitomycin C, whereas no effect was observed after treatment with cyclophosphamide. A comparison with published data for the induction of sex-linked recessive lethals showed that, at least for the 3 drugs tested, the use of both tests eliminates false negatives and might comprise a useful procedure for testing mutagenicity in Drosophila.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D005724:Ganglia / Q000187:drug effects*; D005808:Genes, Recessive / Q000187:drug effects; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D009153:Mutagens; D012730:Sex Chromosomes / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D009153:Mutagens; D001761:Bleomycin; D016685:Mitomycin; D003520:Cyclophosphamide