Effect of hexachlorocyclohexane on diethylnitrosamine-induced hepatocarcinogenesis in rat and its failure to promote skin tumors on dimethylbenz[a]anthracene initiation in mouse.
The promoting action of hexachlorocyclohexane (HCH) was evaluated in female Wistar rats by counting the gamma-glutamyltranspeptidase-positive foci which appeared in the liver after diethylnitrosamine (DENA) initiation. Liver tumor promotion by HCH was further confirmed in a long-term tumorigenicity study after DENA pretreatment. It seems likely that HCH is specific for liver tumor promotion since it failed to promote dimethylbenz[a]anthracene-initiated skin tumors in mice.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D004052:Diethylnitrosamine / Q000633:toxicity*; D004347:Drug Interactions; D005260:Female; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity*; D010704:Phorbols / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D001551:Benz(a)Anthracenes; D009602:Nitrosamines; D010704:Phorbols; D004052:Diethylnitrosamine; D015127:9,10-Dimethyl-1,2-benzanthracene; D001556:Hexachlorocyclohexane; D005723:gamma-Glutamyltransferase; D013755:Tetradecanoylphorbol Acetate