Homogeneous interferon from E. coli depresses hepatic cytochrome P-450 and drug biotransformation.
D000818:Animals; D001711:Biotransformation; D003001:Cloning, Molecular; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004274:DNA, Recombinant / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics*; D006801:Humans; D007372:Interferons / Q000235:genetics / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D011070:Poly I-C / Q000494:pharmacology
D004274:DNA, Recombinant; D007372:Interferons; D003577:Cytochrome P-450 Enzyme System; D011070:Poly I-C