Changes in fast axonal transport during experimental nerve compression at low pressures.
The minimal pressure for impairment of fast anterograde axonal transport was determined in rabbit vagus nerve. Proteins, transported by fast anterograde axonal transport, were labeled by a microinjection of [3H]leucine into the nodose ganglion, and a small compression chamber was applied around the cervical vagus nerve. In this way the nerve was subjected to acute, graded compression. Compression at 20 mm Hg for 2 h as well as sham compression did not induce accumulation of axonally transported proteins at the level of compression. However, a pressure of 30 mm Hg for 2 h induced a block of axonal transport at the site of compression. The causes of the axonal transport block are discussed as well as the minimal pressure level in relation to pressures found in clinical nerve compression lesions.
D000818:Animals; D001370:Axonal Transport; D005260:Female; D008297:Male; D009408:Nerve Compression Syndromes / Q000503:physiopathology*; D011312:Pressure; D011817:Rabbits; D014630:Vagus Nerve / Q000502:physiology