Murine in vivo carrier-specific IgG memory to DNP-Ficoll: variation among inbred strains.
BALB/cAnN and C3H/HeN mice were primed and challenged with DNP-Ficoll, a thymic independent (TI-2) antigen. They developed significant carrier-specific IgG memory responses: DNP-pneumococcal polysaccharide or DNP-hemocyanin challenge did not elicit memory responses. NZB/B1NJ mice failed to develop this memory response. Genetically controlled events apparently regulate the phenotypic expression of this effect.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology*; D000939:Epitopes; D005362:Ficoll / Q000276:immunology*; D005802:Genes, MHC Class II; D006433:Hemocyanins / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007156:Immunologic Memory; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008814:Mice, Inbred NZB; D009578:Nitrobenzenes / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*
D004136:Dinitrobenzenes; D000939:Epitopes; D007074:Immunoglobulin G; D009578:Nitrobenzenes; D011134:Polysaccharides; D005362:Ficoll; D006433:Hemocyanins