[Local hyperthermo-chemotherapy plus ethanol for advanced esophageal cancer].
Eight esophageal squamous cell cancer patients were treated with local hyperthermochemotherapy plus ethanol in addition to bypass surgery and supraclavicular esophagostomy. Local hyperthermochemotherapy plus ethanol treatment was as follows: The esophagus was perfused for one hour using esophagostomy with warmed saline (42-44 degrees C) containing 6-10% ethanol, the overflowing saline was aspirated. Simultaneously, 15 mg Bleomycin or 10 mg Peplomycin was administered intravenously and 5 mg Bleomycin or Peplomycin was administered directly to the esophageal site. This procedure was repeated twice a week for a total of 10 to 24 times. Six of the 8 patients (75%) thus treated showed a shortening of the duration of the shadow defect in X-radiograms. In one case, the lesion was removed and the patient is doing well 9 months after the operation.
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D004938:Esophageal Neoplasms / Q000628:therapy*; D004944:Esophagoplasty / Q000379:methods; D000431:Ethanol / Q000008:administration & dosage*; D005260:Female; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D017663:Peplomycin
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D000431:Ethanol; D017663:Peplomycin