A mysterious extrafraction in the gamma area of protein electrophoresis in dialysis patients is found to be fibrinogen.
The appearance of a heretofore unnoticed extrafraction in the gamma protein electrophoresis of 17 dialyzed patients was linked to the modified Shaldon dialysis catheter. Medication interference, infection, and immunological or hematological disease as causative factors were ruled out. After initial contradictory results, the extrafraction was determined to be fibrinogen, present because of the slow release of heparin contained in the catheter, so that electrophoresis was performed on plasma instead of on serum.
D002404:Catheterization / Q000295:instrumentation; D004588:Electrophoresis, Cellulose Acetate; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007122:Immunoelectrophoresis; D006435:Renal Dialysis; D005719:gamma-Globulins / Q000032:analysis*
D005719:gamma-Globulins; D005340:Fibrinogen