title: Isotype of protective anti-Salmonella antibodies in experimental mouse salmonellosis.
abstract: Mice and a rabbit were immunized with heat-killed Salmonella typhimurium bacteria or with an O-4,12 antigen-specific octasaccharide-protein conjugate. Immunoglobulin isotypes of the antisera were tested for their capacity to protect mice against experimental salmonellosis. Antibodies of immunoglobulin M + A isotypes were more protective than the immunoglobulin G antibodies in each of the two pools of mouse sera. The same protective pattern was also seen with a rabbit antiserum elicited by the artificial octasaccharide-protein conjugate, i.e., with antibodies with the exclusive specificity for the O-4,12 antigen determinants of S. typhimurium.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D051379:Mice; D019081:O Antigens; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012486:Salmonella typhimurium / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D019081:O Antigens