Decrease of plasma fibronectin concentration following infusion of a gelatin-based plasma substitute in man.
Intravenous infusion of 500 ml of a gelatin-based plasma substitute, Haemaccel, given to healthy volunteers, resulted in a significant decrease of the immunoreactive plasma fibronectin concentration 48 h and 72 h after infusion. One hour after infusion, the ability of fibronectin to bind gelatin was inhibited with a gradual recovery within 48 h. A dextran based plasma substitute, Macrodex, did not have this effect on plasma fibronectin.
D000328:Adult; D003911:Dextrans; D005260:Female; D005353:Fibronectins / Q000097:blood*; D005780:Gelatin; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000008:administration & dosage*
D003911:Dextrans; D005353:Fibronectins; D010952:Plasma Substitutes; D005780:Gelatin