title: Unit study in cat claustrum of the effects of iontophoretic neurotransmitters and correlations with the effects of activation of some afferent pathways.
abstract: Glutamate (Glut), acetylcholine (ACh) and dopamine (DA) were iontophoretically applied on cat claustral neurons. Glut did not affect all the neurons; ACh had both excitatory and inhibitory effects, while DA was prevalently inhibitory. An analysis was made of the time-course of excitatory and inhibitory responses on the basis of the mean firing rate variations during and after ACh and DA release. Three types of responses are described for each drug: short lasting inhibition, long lasting inhibition and long lasting excitation. The experimental data were statistically elaborated. The effects of ACh and of DA were compared with those of activation obtained by sensorial peripheric and thalamic stimulations. ACh could be supposed to be the transmitter of most of the inhibitory terminals of these sensitive afferences to the claustrum.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000161:Acoustic Stimulation; D000344:Afferent Pathways / Q000187:drug effects*; D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects*; D002415:Cats; D004298:Dopamine / Q000494:pharmacology; D007478:Iontophoresis; D018377:Neurotransmitter Agents / Q000494:pharmacology*
chemical_list: D018377:Neurotransmitter Agents; D000109:Acetylcholine; D004298:Dopamine