Developmental profiles of substance P and GABA contents in the substantia nigra of rat.
The developmental changes of concentrations of substance P and GABA in the substantia nigra at various postnatal ages of the rat were investigated. Both substance P and GABA were present in measurable amount at birth and continuously increased with age thereafter. When the two curves were compared, GABA seemed to develop slightly faster than substance P in the substantia nigra. Therefore, in contrast to previous reports, there was no discontinuously rapid increase in the concentrations of these transmitter candidates during normal postnatal development of the rat substantia nigra.
D000818:Animals; D011863:Radioimmunoassay; D051381:Rats / Q000254:growth & development*; D011919:Rats, Inbred Strains; D013373:Substance P / Q000032:analysis*; D013378:Substantia Nigra / Q000032:analysis / Q000254:growth & development*; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D013373:Substance P; D005680:gamma-Aminobutyric Acid