title: [Cross-reacting intraspecific antigens of Neisseria meningitidis. I. The isolation, immunochemical and serological characteristics of the cross-reacting antigens of N. meningitidis serogroup A].
abstract: New data on the cross-reacting antigen of N. meningitidis, serogroup A, are presented. A complex of antigens has been isolated by treatment with tryptone X-100, ethanol precipitation and the subsequent treatment with trichloroacetic acid. The immunological analysis of the isolated preparation has shown that the proteinaceous part of the biopolymer contains 7 polypeptide fragments; of these, one fragment with a molecular weight of 31000 daltons has been found to constitute 49, 15% of all polypeptide fragments. The evaluation of the serological properties of this preparation in the precipitation test and the passive hemagglutination test has revealed that the preparation contains various cross-reactive antigenic determinants. Polyvalent erythrocyte diagnosticum obtained on the basis of this preparation permits the detection of antibodies to meningococci irrespective of their serogroup.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000032:analysis* / Q000145:classification / Q000302:isolation & purification; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology; D007120:Immunochemistry; D008297:Male; D009345:Neisseria meningitidis / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D012703:Serotyping; D012756:Sheep / Q000276:immunology; D013045:Species Specificity
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000939:Epitopes
vernacular_title: Perekrestno reagiruiushchie vnutrividovye antigeny Neisseria meningitidis. Soobshchenie L. Vydelenie, immunokhimicheskaia i serologicheskaia kharakteristika perekrestno reagiruiushchikh antigenov N. meningitidis serogruppy A.