The renin-angiotensin-aldosterone system in rats of both sexes subjected to chronic hypobaric hypoxia.
Plasma renin activity (PRA), plasmatic aldosterone, haematocrit, haemoglobin concentration and plasma proteins were measured in 36 Wistar rats of both sexes submitted to 380 mmHg in hypopressure chamber during 7 months and in a group of control animals (15 male and 15 female rats). PRA was significantly increased in hypoxic male (P less than 0.05) and female (P less than 0.01) rats. On the contrary, plasma aldosterone concentration did not show any significant variation. There thus was a clear dissociation between the plasmatic renin-angiotensin system and the aldosterone in rats of both sexes submitted to severe chronic hypobaric hypoxia.
D000450:Aldosterone / Q000097:blood; D000818:Animals; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System; D012737:Sex Factors
D006454:Hemoglobins; D000450:Aldosterone; D012083:Renin