[Dependence of cordycepin inhibition of heterogeneous nuclear RNA biosynthesis in rat brain on the size of the poly(A) segments].
A study was made of the effect of cordicepin on the biosynthesis of rat brain heterogeneous nuclear RNA (hnRNA) fractions, such as poly(A-)hnRNA, oligo(A+)hnRNA and poly(A+)hnRNA differing in the size of poly(A)-segments. Cordicepin was shown to inhibit the biosynthesis of poly(A+)hnRNA alone. However, small doses of the antibiotic do not virtually inhibit the biosynthesis of hnRNA with shorter segments of poly(A). At the same time they inhibit the biosynthesis of hnRNA containing long chains of poly(A) in the 3'-end. A possible molecular mechanism of the phenomenon reviewed is under discussion.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003839:Deoxyadenosines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011061:Poly A / Q000037:antagonists & inhibitors*; D012313:RNA / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D003839:Deoxyadenosines; D011061:Poly A; D012313:RNA
Zavisimost' ingibirovaniia biosinteza geterogennoĭ iadernoĭ RNK mozga krys korditsepinom ot razmerov segmentov poli(A).