title: Mallory bodies: lesions of hepatocytes containing proteins of the keratin-myosin-epidermin group.
abstract: Mallory's alcoholic hyalin in hepatocytes was found also in other diseases and is now referred to as Mallory bodies. Data concerning their histochemical, immuno and electron microscopic properties are partly contradictory. In this study, early stages of Mallory bodies reacted strongly with configurational technics for myosins; affinity tended to decrease when material with the properties of keratohyalin and the matrix of stratum corneum was formed. Thus, many Mallory bodies contained histochemically distinct myoid and keratin-like proteins. Electron microscopists demonstrated thick and thin filaments resembling contractile systems in Mallory bodies; the failure of immunologists to visualize actomyosin may be due to the heterogeneity of these proteins. The currently popular term prekeratin has been applied to a variety of substances extracted from epidermis, hoof and hair under different conditions. The prekeratin of recent immunofluorescence studies seems to contain mainly epidermin and low molecular matrix proteins; both were studied extensively by chemists. Epithelial filaments, including tonofibrils and contractile fibrils regarded as a subgroup of myofibrils, were well known half a century ago, but were banished by electron microscopy. Observations in this study and data on epidermal actomyosin indicate that different proteins of the k-m-e-f group can indeed coexist in epithelial cells. The formation and resolution of Mallory bodies can be regarded as an example of the well known shifts of epithelial cells between secretory and keratinizing states.
mesh_terms: D003594:Cytoplasmic Granules / Q000032:analysis; D003599:Cytoskeleton / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D006818:Hyalin / Q000032:analysis*; D007633:Keratins / Q000032:analysis*; D008099:Liver / Q000032:analysis / Q000648:ultrastructure*; D009218:Myosins / Q000032:analysis*; D013194:Staining and Labeling
chemical_list: C001500:keratohyalin; D007633:Keratins; D009218:Myosins