[Effect of substance P on blood pressure in rats, with and without hypokinetic stress].
The effect of substance P (SP) on blood pressure was studied in normotensive rats and in rats with hypokinesia-induced hypertension. To characterize the SP effect, the influence on the blood pressure value, intra-individual variation and interindividual changes was investigated. Whereas SP corrected the hypokinesia-induced changes (increased blood pressure, increase in the intra-individual blood pressure variations) in the stressed animals, no SP effect was observed in the normotensive control rats. These findings are discussed with a view to the assumed ability of SP to act as a regulatory peptide (regulide).
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006973:Hypertension / Q000503:physiopathology; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*; D013373:Substance P / Q000494:pharmacology*; D013997:Time Factors
D013373:Substance P
Wirkung von Substanz P auf den Blutdruck von Ratten mit und ohne Hypokinesebelastung.