[Effectiveness of dsRNA as an interferon inducer in the intramuscular infection of mice with rabies street virus].
A protective effect of double-stranded RNA as interferon inducer was demonstrated in mice inoculated intramuscularly with street rabies virus. A significant degree of protection was observed when the inducer was inoculated intracerebrally and at the site of virus inoculation both 24 h before and 4 and 24 h after infection. Inoculation of the inducer into the muscle opposite to the infected leg and subcutaneously into the back proved to be ineffective. It was established that rabies infection could be arrested with the interferon inducer depending on the site of its inoculation.
D000818:Animals; D001921:Brain; D004353:Drug Evaluation, Preclinical; D005260:Female; D007267:Injections; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007369:Interferon Inducers / Q000627:therapeutic use*; D007372:Interferons / Q000032:analysis; D008297:Male; D051379:Mice; D012330:RNA, Double-Stranded / Q000627:therapeutic use*; D011818:Rabies / Q000517:prevention & control*; D013997:Time Factors
D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D007372:Interferons
Effektivnost' dsRNK kak induktora interferona pri vnutimyshechnom zarazhenii mysheĭ ulichnym virusom beshenstva.