HLA class I genes integrated into murine cells are inducible by interferon.
In human cells treated with interferon, there is an increase in the amount of HLA-A, B, C mRNA and, to a lower extent, membrane-bound antigen. However, the mechanism of this mRNA enhancement is still unknown. Using mouse L cells transfected with a unique class I HLA gene, we were able to show that both the related HLA mRNA and protein are increased after murine but not human interferon treatment. Moreover, the discrepancy between interferon-directed HLA mRNA and protein enhancement is also observed. The mouse transfected cells allowed us to study more precisely the origin of this discrepancy.
D000818:Animals; D000937:Antigen-Antibody Reactions; D005434:Flow Cytometry; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000032:analysis / Q000145:classification / Q000235:genetics*; D006801:Humans; D007372:Interferons / Q000502:physiology*; D007700:Kinetics; D007739:L Cells / Q000032:analysis* / Q000276:immunology; D051379:Mice; D012333:RNA, Messenger / Q000032:analysis
D006680:HLA Antigens; D012333:RNA, Messenger; D007372:Interferons