[Effect of acetylcholine on incorporation of 14C-precursors into uridylic and cytidylic nucleotides of the RNA of digestive glands].
The incorporation rate of [2-14C]orotic acid and [2-14C]uridine into the cytidylic RNA nucleotides is significantly lower than into the uridylic ones. In the liver it was twice as low as in the stomach mucosa or in pancreas of albino rats. The administration of acetylcholine in combination with proserine has no influence on the RNA content and its nucleotide composition in the tissues. The administered drugs however caused changes in the relation of the incorporation rates of both labels into uridylic and cytidylic RNA nucleotides, which evidences for the uridylic nucleotide synthesis. In the liver such changes are not detected, but utilization of the labeled uridine is shown to be more intensive for the cytidylic RNA nucleotides synthesis.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D003568:Cytidine Monophosphate / Q000096:biosynthesis; D003597:Cytosine Nucleotides / Q000096:biosynthesis*; D005753:Gastric Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014500:Uracil Nucleotides / Q000096:biosynthesis*; D014542:Uridine Monophosphate / Q000096:biosynthesis
D003597:Cytosine Nucleotides; D014500:Uracil Nucleotides; D012313:RNA; D014542:Uridine Monophosphate; D003568:Cytidine Monophosphate; D000109:Acetylcholine
Vkliuchenie 14C-predshestvennikov v uridilovye i tsitidilovye nukleotidy RNK pishchevaritel'nykh zhelez pod vliianiem atsetilkholina.