Effect of somatostatin on exocrine pancreas evaluated on a total external pancreatic fistula of neoplastic origin.
A patient with a pancreatic fistula, with a defunctionalized duodenum (subsequent to a previously performed Billroth II gastrectomy for cancer and choledochojejunostomy for metastatic infiltration in the bile duct) was submitted to prolonged synthetic somatostatin infusion (48 h). There was a mean reduction of 80% in pancreatic output, with no changes in the composition of sodium, potassium, and calcium, an increase in chloride and a decrease in bicarbonate. An increase in amylase was noted. The unique clinical features of this case have provided direct confirmation of the inhibiting action of somatostatin on the exocrine pancreas.
D000368:Aged; D000681:Amylases / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism; D006801:Humans; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010185:Pancreatic Fistula / Q000209:etiology / Q000503:physiopathology*; D013004:Somatostatin / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000150:complications
D004573:Electrolytes; D013004:Somatostatin; D000681:Amylases