Protective effect of L-ascorbic acid in lindane intoxicated rats.
Administration of lindane at a dose of 20 mg/kg body weight/day for 15 days to male rats brought about marked growth retardation. Succinic dehydrogenase, Mg2+-ATPase and glucose-6-phosphatase activities were inhibited in different fractions of liver tissues. Mg2+-ATPase, alkaline phosphatase and NADH-dehydrogenase activities were also inhibited in the liver plasma membranes of the lindane treated animals. Stimulation of 5'-nucleotidase activity in liver plasma membrane was observed under lindane intoxication. Supplementation of L-ascorbic acid by separate oral administration to the lindane intoxicated rats neutralized the growth retardation and maintained almost normal values of all the enzymes studied.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D017301:Ca(2+) Mg(2+)-ATPase; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D050544:L-Gulonolactone Oxidase; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D008297:Male; D009245:NADH Dehydrogenase / Q000378:metabolism; D009708:Nucleotidases / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013401:Sugar Alcohol Dehydrogenases / Q000378:metabolism
D001556:Hexachlorocyclohexane; D013401:Sugar Alcohol Dehydrogenases; D050544:L-Gulonolactone Oxidase; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D009708:Nucleotidases; D000469:Alkaline Phosphatase; D005952:Glucose-6-Phosphatase; D000251:Adenosine Triphosphatases; D017301:Ca(2+) Mg(2+)-ATPase; D001205:Ascorbic Acid