Polyamine profiles in human pathological prostate tissue.
Polyamine concentrations were determined in homogenized specimens of human prostatic tissue obtained at open surgery from patients with benign prostatic hypertrophy, some of whom had been treated with oestrogens or anti-androgens, and from patients with prostatic adenocarcinoma in whom the tissues were removed by transurethral resection. The results show that in treated benign prostatic hyperplasia there is a lower polyamine concentration. Homogenates of tissues from patients with prostatic cancer show no specific polyamine profile.
D000230:Adenocarcinoma / Q000378:metabolism; D000726:Androgen Antagonists / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D006801:Humans; D008297:Male; D011073:Polyamines / Q000032:analysis*; D011467:Prostate / Q000032:analysis*; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism
D000726:Androgen Antagonists; D004967:Estrogens; D011073:Polyamines