Interferon modifies morphine withdrawal phenomena in rodents.
Interferon injection in morphine dependent rats prior to naloxone treatment eliminates 7 behavioral sings of the abstinence (withdrawal) phenomenon. When a single injection of interferon was given prior to chronic morphine treatment it reduces opiate addiction liability.
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009021:Morphine Dependence / Q000188:drug therapy; D009270:Naloxone / Q000627:therapeutic use; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D009270:Naloxone; D009020:Morphine; D007372:Interferons