Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity.
D000818:Animals; D001693:Biological Transport, Active; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003201:Computers; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008727:Methotrexate / Q000378:metabolism* / Q000627:therapeutic use; D051379:Mice; D010455:Peptides / Q000378:metabolism*; D011099:Polyglutamic Acid / Q000378:metabolism*
D010455:Peptides; D011099:Polyglutamic Acid; D008727:Methotrexate