[Oxidative damage of mice erythrocytes infected with Plasmodium berghei].
By using the model of infection with plasmodium berghei in white mice the attempt was made to explain the oxidative damages of red blood cells as a cause for haemolysis. In addition to a diminished new formation of erythrocytes there was an increased cell lysis under the impact of infection. Without any changes of the Met-Hb-percentage and of Heinz bodies an increase of GSH and GSSG could be measured. The conclusion was drawn that a damage of red blood cells caused by oxidation may occur by changing the relation of reduced tripeptides to oxidised ones.
D000818:Animals; D004195:Disease Models, Animal; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology / Q000473:pathology*; D005978:Glutathione / Q000097:blood; D006366:Heinz Bodies; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D008288:Malaria / Q000097:blood*; D008297:Male; D008706:Methemoglobin / Q000032:analysis; D051379:Mice; D008813:Mice, Inbred ICR; D010084:Oxidation-Reduction; D010962:Plasmodium berghei / Q000254:growth & development
D006454:Hemoglobins; D008706:Methemoglobin; D005978:Glutathione
Oxidative Schädigung an Erythrozyten der Maus unter einer Infektion mit Plasmodium berghei.