Substance P release from K+-depolarized rat brain synaptosomes at one-second resolution.
Substance P release from isolated nerve endings (synaptosomes) prepared from rat brain occurred primarily within the first second of continuous K+-depolarization. If the concentrations of K+ or Ca2+ were decreased there was less substance P release, but the time course of release was similar. Thus the rapid release of substance P occurs over a wide range of depolarization conditions.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001933:Brain Stem / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects; D008636:Mesencephalon / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D013373:Substance P / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects*; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D013788:Thalamus / Q000187:drug effects
D013373:Substance P; D011188:Potassium