title: Irritation and staining by dithranol (anthralin) and related compounds. III. Cumulative irritancy and staining during repeated chamber testing.
abstract: Irritation and staining, the side effects of dithranol and related compounds have previously been studied after a single chamber-exposure. To mimic the therapeutic situation, the chamber application was repeated for 3 weeks on the uninvolved back skin of 17 psoriasis patients. In equimolar concentrations corresponding to 0.05% dithranol, dithranol caused markedly more erythema and staining than 10-propionyl dithranol and 10-butyryl dithranol, whereas 10-butyryl dithranol irritated and stained less than 10-propionyl dithranol. To reach the irritation and staining level of dithranol, a 4-fold higher concentration of 10-butyryl dithranol was required. During the first week the irritation culminated, declining later despite repeated applications, possibly because of exhaustion of anthrone-induced inflammatory mediators.
mesh_terms: D000873:Anthracenes / Q000009:adverse effects*; D000875:Anthralin / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives; D004890:Erythema / Q000139:chemically induced*; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests / Q000379:methods
chemical_list: D000873:Anthracenes; D007509:Irritants; C038463:10-propionyl dithranol; C038464:butantrone; D000875:Anthralin