Therapy of extragonadal germ-cell tumors.
Sixteen patients with primary extragonadal germ-cell tumors were treated at the Department of Chemotherapy, Finsen Institute, Copenhagen from 1976 to 1982. Twelve patients received a combination of cis-diamminedichloroplatinum (cisplatin), vinblastine and bleomycin (PVB). Eight patients had a complete remission and 5 had a partial response. Eighty-six percent of the patients achieving complete remission remain free of disease after a median follow-up of 42 months. The best results with PVB were obtained in teratocarcinomas and embryonal carcinomas, while more effective chemotherapy regimens are needed for the treatment of choriocarcinomas and endodermal sinus tumours.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin / Q000008:administration & dosage*; D002822:Choriocarcinoma / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004407:Dysgerminoma / Q000188:drug therapy; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy*; D008649:Mesonephroma / Q000188:drug therapy; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy*; D013724:Teratoma / Q000188:drug therapy; D014747:Vinblastine / Q000008:administration & dosage*
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin