[Characteristics of nucleic acid biosynthesis in the activation of erythroid cell proliferation due to prolonged gamma irradiation].
Most important differences were detected in the nucleic acid metabolism in the rat spleen with increasing proliferation of erythroid cells under the effect of long-term gamma-irradiation and acute hemolytic anemia. It is assumed that humoral regulation pathways and molecular mechanisms of changes in erythropoiesis depend upon haemopoietic stem cell pool.
D000208:Acute Disease; D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced; D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis*; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D010659:Phenylhydrazines / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010659:Phenylhydrazines; D012313:RNA; D004247:DNA
Osobennosti biosinteza nukleinovykh kislot pri aktivatsii proliferatsii éritroidnykh kletok, vyzvannoĭ dlitel'nym gamma-oblucheniem.