[Effect of a number of antitumor preparations on RNA- and protein-synthesizing processes and viral interferon induction in Krebs 2 ascites carcinoma cells].
Antitumor drugs: adenosine cyclophosphane, adenosine thiophosphamide, colchamine thiophosphamide, and tribetamide inhibited RNA biosynthesis in Krebs-II ascitic carcinoma cells and in similar concentrations they were much less inhibiting for protein-synthesizing processes (in cells and cell-free protein-synthesizing system). The drugs could inhibit interferon synthesis, possibly after virus induction, in Krebs-II ascitic carcinoma cells only in concentrations significantly inhibiting the synthesis of cellular macromolecules.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002287:Carcinoma, Krebs 2 / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D002474:Cell-Free System / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004686:Encephalomyocarditis virus / Q000276:immunology; D066298:In Vitro Techniques; D007372:Interferons / Q000096:biosynthesis*; D007739:L Cells / Q000276:immunology / Q000378:metabolism; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009522:Newcastle disease virus / Q000276:immunology; D012334:RNA, Neoplasm / Q000096:biosynthesis*
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D007372:Interferons
Izuchenie vliianiia riada protivoopukholevykh preparatov na RNK- i beolksinteziruiushchie protsessy i virusnuiu induktsiiu interferona v kletkakh astsitnoĭ kartsinomy Krebs-II.