title: Evidence for non-random sequence of centromere separation in muntjak chromosomes by high resolution TV-microscopy.
abstract: The sequence of separation of sister centromeres in the chromosomes of the muntjak was analysed using a high resolution TV-microscope-system. Computer programs which permit the identification of the individual chromosome pairs and the measurement of the distances between the sister centromeres are described. The study demonstrates that the centromeres do not separate in a random sequence. It could be shown that the amount of pericentromeric heterochromatin participates in the control of centromere separation; however, other factors must also be involved. The significance of the asynchronous division of centromeres in the origin of aneusomic cells in mammals is discussed.
mesh_terms: D000818:Animals; D002455:Cell Division; D002875:Chromosomes / Q000502:physiology*; D003670:Deer / Q000235:genetics*; D005347:Fibroblasts / Q000166:cytology; D008297:Male; D008677:Metaphase; D012984:Software; D013194:Staining and Labeling; D013690:Television