Substance K: a novel mammalian tachykinin that differs from substance P in its pharmacological profile.
The primary structure of one of the bovine brain substance P precursors has shown the existence of a second mammalian tachykinin sequence, named substance K, that is remarkably homologous to that of the amphibian peptide kassinin. In this study, three substance K sequences were chemically synthesized and were submitted to parallel bioassays with kassinin, substance P and physalaemin. The results show that the three substance K peptides all possess biological activities characteristic of the tachykinin family and that their biological activities more closely resemble those of kassinin than those of substance P or physalaemin. This suggests that substance K may have a physiological role which is related to but different from that of substance P in mammalian organisms.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D015286:Kassinin; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D015288:Neurokinin A; D009842:Oligopeptides / Q000494:pharmacology*; D010803:Physalaemin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D009842:Oligopeptides; D010803:Physalaemin; D013373:Substance P; D015286:Kassinin; D015288:Neurokinin A