title: Function of anti-Streptococcus mutans antibodies: anti-ribosomal antibodies inhibit acid production, growth, and glucose phosphotransferase activity.
abstract: Antibodies induced in sera and saliva of rats and rabbits immunized with ribosomal preparations from Streptococcus mutans 6715 inhibited transport of glucose by the phosphotransferase system by greater than 60%, acid production from sucrose by greater than 95%, and growth of the homologous S. mutans by greater than 59%. Inhibition of growth and acid production by immune sera and saliva were abrogated by prior adsorption with S. mutans 6715 whole cells, glucosyltransferase, lipoteichoic acid, or alpha 1-6 or alpha 1-3 dextran. These results indicate that antibodies induced to an S. mutans ribosomal preparation react with cell surface determinants and suggest that the antibodies inhibit sucrose-induced acid formation and growth of virulent S. mutans by neutralizing the glucose-phosphotransferase system.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D003911:Dextrans / Q000096:biosynthesis; D005964:Glucosyltransferases / Q000378:metabolism; D008070:Lipopolysaccharides; D010712:Phosphatidic Acids / Q000096:biosynthesis; D011817:Rabbits; D051381:Rats; D012270:Ribosomes / Q000276:immunology* / Q000378:metabolism; D012463:Saliva / Q000276:immunology; D013295:Streptococcus mutans / Q000254:growth & development* / Q000276:immunology*; D013682:Teichoic Acids / Q000096:biosynthesis
chemical_list: D000907:Antibodies, Bacterial; D003911:Dextrans; D008070:Lipopolysaccharides; D010712:Phosphatidic Acids; D013682:Teichoic Acids; C009900:lipoteichoic acid; D005964:Glucosyltransferases