CSF 5-hydroxyindoleacetic acid levels in suicidal schizophrenic patients.
Concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in the lumbar CSF were measured in a group of suicidal schizophrenic patients and in a matched group of nonsuicidal schizophrenic patients. The suicidal group had a significantly lower level. This finding is consistent with reports of low levels of CSF 5-HIAA in suicidal patients with other psychiatric diagnoses and suggests that low CSF 5-HIAA may be a generalized marker of aggressive behavior against the self and others.
D000328:Adult; D000374:Aggression / Q000523:psychology; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D001523:Mental Disorders / Q000134:cerebrospinal fluid / Q000523:psychology; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D012565:Schizophrenic Psychology; D013405:Suicide / Q000523:psychology*
D006897:Hydroxyindoleacetic Acid