Evaluation of (D-Pro2, D-Trp7,9)-substance P as an antagonist of substance P responses in the rat central nervous system.
The (D-Pro2, D-Trp7,9) analogue of substance P has been tested for substance P antagonist activity in the caudal trigeminal nucleus in vivo, and in the isolated spinal cord in vitro. In neither case was the analogue found to be a specific antagonist of substance P, although the analogue did have weak antagonist actions in the isolated guinea-pig ileum preparation. It is concluded that the analogue is not a suitable tool for the identification of putative substance P systems in the spinal cord or the caudal trigeminal nucleus of the rat.
D000818:Animals; D001681:Biological Assay; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014275:Trigeminal Caudal Nucleus / Q000187:drug effects / Q000502:physiology*; D014279:Trigeminal Nucleus, Spinal / Q000502:physiology*
D013373:Substance P; C032132:substance P, prolyl(2)-tryptophan(7,9)-