[Interaction of polymorphonuclear leukocytes, bradykinin and carragenin. Transference reaction in the rat].
1. Injected in the paw of the rat, polymorphonuclear leucocytes do not increase the oedematogen action of bradykinin, but increase the action of lambda carrageenan. 2. This potentiation of carrageenan action is not modified when PG biosynthesis in leucocytes is inhibited by indomethacin or aspirin. It does not appear in rats previously treated by indomethacin or aspirin. 3. Our results suggest that rat polymorphonuclear leucocytes increase the inflammatory reaction, when they are stimulated by carrageenan, by the release of a phospholipase A2 activity which induces PG biosynthesis in rat paw tissues.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001920:Bradykinin / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology*; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced; D007213:Indomethacin / Q000494:pharmacology; D009504:Neutrophils / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D002351:Carrageenan; D010741:Phospholipases A; D054467:Phospholipases A2; D001241:Aspirin; D001920:Bradykinin; D007213:Indomethacin
Interaction polynucléaires, bradykinine et carragénine. La réaction de transfert chez le rat.