The release of histamine from the pars flaccida mast cells one cause of otitis media with effusion?
In this experimental study in the rat, compound 48/80--a potent degranulating drug of mast cells--was instilled in the external auditory meatus towards the tympanic membrane. Moreover, effusion material was produced in the attic space by blocking the tympanic isthmus with a piece of Gelfoam applied through the tympanic bulla. Both these procedures caused a degranulation of the pars flaccida mast cells and subsequently histamine was detected in the rinsing fluid collected from the middle ear cavity. A possible direct cause of the effusion material in the middle ear cavity may be a degranulation of the pars flaccida mast cells, thus resembling an allergic reaction Type I.
D000818:Animals; D005064:Eustachian Tube; D006636:Histamine Release; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D010033:Otitis Media / Q000209:etiology*; D010034:Otitis Media with Effusion / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014432:Tympanic Membrane / Q000378:metabolism* / Q000473:pathology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003189:p-Methoxy-N-methylphenethylamine