title: Gene(s) affecting the expression of Qa-1.
abstract: Lymphocytes from different strains vary in their expression of antigenic determinants encoded by the Qa1 locus. Thus, a lower percentage of cells from strains bearing H-2Dk are lysed in antibody-mediated cytotoxic tests. These cells fail to completely absorb anti-Qa1 activity from antisera. The unexpressed determinants are present in unactivated cells when subcellular fractions are tested and are detectable on the membrane of mitogen-activated lymphocytes. The gene(s) controlling this phenomenon are dominant and map to a region between H-2S and Tla.
mesh_terms: D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface / Q000235:genetics*; D002874:Chromosome Mapping; D000939:Epitopes; D005260:Female; D005786:Gene Expression Regulation; D005796:Genes; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice
chemical_list: D000954:Antigens, Surface; D000939:Epitopes; D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I; D007518:Isoantibodies; C032907:Q surface antigens