Failure to pace following high dose antiarrhythmic therapy--reversal with isoproterenol.
A patient with resistant ventricular tachycardia treated with a combination of antiarrhythmic agents is described. Sudden onset of a wide complex ventricular rhythm with periods of asystole and failure to achieve transvenous pacing were observed, presumably due to antiarrhythmic drug toxicity. Inability to pace was reversed by the infusion of isoproterenol.
D000638:Amiodarone / Q000009:adverse effects; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D004206:Disopyramide / Q000009:adverse effects; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D006801:Humans; D007545:Isoproterenol / Q000627:therapeutic use*; D010138:Pacemaker, Artificial; D010672:Phenytoin / Q000009:adverse effects; D011342:Procainamide / Q000009:adverse effects; D013610:Tachycardia / Q000188:drug therapy* / Q000628:therapy
D000889:Anti-Arrhythmia Agents; D010672:Phenytoin; D004206:Disopyramide; D011342:Procainamide; D007545:Isoproterenol; D000638:Amiodarone