title: CSF cortisol in patients with depression, mania, or anorexia nervosa and in normal subjects.
abstract: The authors studied CSF cortisol in 30 depressed patients, 10 manic patients, 21 women with anorexia nervosa, and 22 normal control subjects. All patients were also rated on a global severity scale for mania or depression. Results indicated higher CSF cortisol levels in all three patient groups than in the control group. Only the depressed group had a significant positive correlation between CSF cortisol and severity ratings. The authors recommend further research into the hypothalamic mechanisms associated with cortisol secretion and regulation.
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000134:cerebrospinal fluid*; D000856:Anorexia Nervosa / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000134:cerebrospinal fluid* / Q000502:physiology; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007031:Hypothalamus / Q000503:physiopathology; D008297:Male
chemical_list: D006897:Hydroxyindoleacetic Acid; D006854:Hydrocortisone