title: [Antiviral and therapeutic action of protease inhibitors in viral infections: experimental and clinical observations].
abstract: The effect of protease inhibitors (gordox, contrycal, epsilon-aminocapronic acid) on the development of influenza virus-induced infectious process was studied. Administration of the above-mentioned drugs exerted a marked antiviral and therapeutic effect both in animal experiments and in treatment of children suffering from influenza. Electron microscopic examinations of lungs from influenza virus-infected animals treated with protease inhibitors revealed definite decrease in the number of virus particles and significant diminution of pathological lesions; the changes were noted which indicated activation of the body immune response. The use of a protease inhibitor, epsilon-aminocapronic acid, in children with influenza shortened the duration of influenza virus antigens persistence in the nasopharyngeal epithelium and reduced the duration of the disease symptoms by 1 1/2-2-fold. Administration of epsilon-aminocapronic acid in inhalations exerted most effective antiviral and therapeutic effect. The results obtained demonstrate the possibility of influenza treatment with inhibitors of proteolytic enzymes.
mesh_terms: D000293:Adolescent; D015119:Aminocaproic Acid / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D007611:Aprotinin / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000188:drug therapy* / Q000473:pathology; D008168:Lung / Q000648:ultrastructure; D051379:Mice; D011480:Protease Inhibitors / Q000627:therapeutic use*; D014361:Trypsin Inhibitors / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; C011475:gordox; D007611:Aprotinin; D015119:Aminocaproic Acid
vernacular_title: Protivovirusnoe i terapevticheskoe deĭstvie ingibitorov proteaz pri virusnykh infektsiiakh: éksperimental'nye i klinicheskie nabliudeniia.