title: [Proteinase inhibitor activity of blood plasma and cerebrospinal fluid in patients with pituitary adenomas before and after proton therapy].
abstract: 35 patients with somatotropic adenoma of hypophysis were examined before proton therapy and within 3 years after the treatment. High initial level of alpha 1-antitrypsin(alpha 1-AT) and alpha 2-macroglobulin (alpha 2-MG) in the patients blood plasma as well as a decrease in alpha 1-AT activity in cerebrospinal fluid were observed. Within a year after the proton hypophysectomy activity of the proteinase inhibitors returned to the normal values in blood and cerebrospinal fluid simultaneously with clinical restoration and a decrease in content of growth hormone; their level were maintained at normal values within the last two years of observation. Estimation of alpha 1-At activity in blood plasma and cerebrospinal fluid might be used as an additional test in evaluation of the treatment course in the patients with somatotropic adenoma of hypophysis.
mesh_terms: D000236:Adenoma / Q000097:blood / Q000378:metabolism* / Q000532:radiotherapy; D000328:Adult; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood / Q000378:metabolism* / Q000532:radiotherapy; D061766:Proton Therapy; D000515:alpha 1-Antitrypsin / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000134:cerebrospinal fluid / Q000378:metabolism*
chemical_list: D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D013006:Growth Hormone
vernacular_title: Aktivnost' ingibitorov proteinaz plazmy krovi i spinnomozgovoĭ zhidkosti u bol'nykh adenomami gipofiza do i posle protonnoĭ terapii.