[Effect of ethanol on the concentration of serotonin in the brain of the rat and the excretion of 5-hydroxyindoleacetic acid].
It is found that serotonin content in the brain areas and heart of rats with low alcohol motivation decreases after 5 months of chronic consumption of 48% ethanol solution in a dose of 4 g/kg; in animals with high alcohol motivation serotonin content decreases only in the hypothalamus. Under chronic alcoholization for 1 and 12 months no considerable changes were found in serotonin level of the studied tissues. 60 min after intraperitoneal administration of 20% ethanol solution in a dose of 3 g/kg in intact animals there occurs an increase of serotonin content in the brain hemispheres and heart and its decrease in the hypothalamus; in rat with low alcohol motivation after taking ethanol for 5 months this administration evokes a decrease of serotonin content in the hypothalamus and truncus cerebri; in rats with high alcohol motivation--its decrease in the hypothalamus. Excretion of 5-oxyindoleacetic acid with urine decreases 10 months after alcohol intoxication. When rats were not given ethanol after its chronic taking for 3 months serotonin oxidation was intensified for the first day, which was not observed after 7-month alcoholization of animals.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D001933:Brain Stem / Q000032:analysis; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D009206:Myocardium / Q000032:analysis; D051381:Rats; D012701:Serotonin / Q000032:analysis*; D013687:Telencephalon / Q000032:analysis
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid
Vliianie étanola na soderzhanie serotonina v golovnom mozgu krys i ékskretsiiu 5-oksiindoliluksusnoĭ kisloty.