Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum.
In the isolated, vascularly perfused guinea-pig ileum, peristalsis could be induced by raising the intraluminal pressure in the presence of atropine. Atropine-resistant peristalsis was greatly inhibited or abolished by the substance P antagonist (D-Pro2, D-Trp7.9)-substance P, substance P desensitization, hexamethonium and by the enkephalin analogue FK 33-824. It is concluded that substance P neurones of the intestine play an important role in the atropine-resistant peristalsis of the guinea-pig ileum.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D004745:Enkephalins / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000294:innervation*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010528:Peristalsis / Q000187:drug effects*; D011312:Pressure; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*
D004745:Enkephalins; D013373:Substance P; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D001285:Atropine; C032132:substance P, prolyl(2)-tryptophan(7,9)-