Comparative studies on the serum levels of alpha-1-antitrypsin and alpha-macroglobulin in several mammals.
The sera of human, cattle, horse, sheep, goat, pig, dog, rabbit, guinea pig, rat, hamster, and mouse were assayed for total trypsin-inhibiting capacity, and for concentrations of alpha-1-antitrypsin and alpha-macroglobulin. The rodents examined showed striking species differences: the alpha-1-antitrypsin levels of mouse, rat, and guinea pig were more than twice the human level, while the alpha-macroglobulin levels of hamster and guinea pig were 340 and 40%, respectively, of the human level. On the other hand, little variations were found among the large domestic animals, their levels of the two inhibitors being similar to those of the human.
D000818:Animals; D002417:Cattle; D006224:Cricetinae; D004285:Dogs; D006041:Goats / Q000097:blood; D006168:Guinea Pigs; D006801:Humans; D008322:Mammals / Q000097:blood*; D051379:Mice; D011817:Rabbits; D051381:Rats; D012756:Sheep / Q000097:blood; D013045:Species Specificity; D013552:Swine / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000032:analysis*; D000511:alpha-Macroglobulins / Q000032:analysis*
D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins