The majority of cDNA clones with strong positive signals for the interferon-induction-specific sequences resemble mitochondrial ribosomal RNA genes.
A complementary DNA library prepared from the 12S polyadenylated RNAs extracted from interferon-induced KG-1 cells, a human myeloblast cell line, was screened for the presence of induction-specific sequences. Clones that exhibited strong positive signals were separated by hybridization criteria into nine classes. Clones from classes I through IV consisted of about 78% of the total and unexpectedly were found to resemble human mitochondrial ribosomal RNA genes.
D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics* / Q000378:metabolism*; D004262:DNA Restriction Enzymes; D004272:DNA, Mitochondrial / Q000235:genetics*; D004275:DNA, Ribosomal; D004926:Escherichia coli / Q000235:genetics; D005260:Female; D005796:Genes; D006801:Humans; D007372:Interferons / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute; D010920:Placenta; D010957:Plasmids; D011061:Poly A / Q000235:genetics; D011247:Pregnancy; D012313:RNA / Q000235:genetics; D012333:RNA, Messenger; D012335:RNA, Ribosomal / Q000235:genetics*
D004272:DNA, Mitochondrial; D004275:DNA, Ribosomal; D012333:RNA, Messenger; D012335:RNA, Ribosomal; D011061:Poly A; D012313:RNA; D004247:DNA; D007372:Interferons; D004262:DNA Restriction Enzymes