Occupational exposure to hexachlorocyclohexane. VI. Metabolism of gamma-hexachlorocyclohexane in man.
Metabolism of gamma-Hexachlorocyclohexane (HCH) was studied examining 21 workers producing this insecticide. Using gas chromatography in combination with ECD and mass spectrometry 14 mono-, di-, tri- and tetrachlorophenols were identified in the urine samples of the workers. Seven dihydroxychlorobenzenes of still unknown configuration were detected by mass spectrometry. Ten of the more abundant metabolites, di-, tri- and tetrachlorophenols were determined quantitatively in all urine samples. 2,4,6-; 2,3,5- and 2,4,5-trichlorophenol turned out to be the main metabolites of gamma-HCH. They were excreted in nearly equal quantities. On account of their potential liver toxicity, the determination of chlorophenols in urine should be part of a biological monitoring program of HCH-exposed persons.
D000328:Adult; D002733:Chlorophenols / Q000652:urine; D004781:Environmental Exposure; D001556:Hexachlorocyclohexane / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D008297:Male; D008875:Middle Aged
D002733:Chlorophenols; D001556:Hexachlorocyclohexane