The cytogenetic efficiency of the antitumor agents bleomycin and peplomycin is enhanced by the heart drug verapamil (isoptin).
The induction of 2-break chromosome aberrations (dicentrics and ring chromosomes) in human lymphocytes by the antitumor agents bleomycin and peplomycin is strongly enhanced when those agents are applied together with the heart drug verapamil (isoptin).
D001761:Bleomycin / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006801:Humans; D017663:Peplomycin; D014700:Verapamil / Q000494:pharmacology*
D001761:Bleomycin; D017663:Peplomycin; D014700:Verapamil