title: Double-blind study of suprofen vs naproxen in the treatment of osteoarthritic pain.
abstract: In a 2-week double-blind study involving 79 patients with mainly osteoarthritis of the hip and knee, Suprofen and Naproxen were compared for efficacy and tolerability in the treatment of the symptoms of the disease. The drugs were administered on a b.i.d. schedule: 800 mg of Suprofen or 750 mg of Naproxen. Nocturnal pain, pain at rest, pain on motion and tenderness were evaluated at baseline and at days 7 and 14. Results showed that patients in both groups were significantly improved in all parameters. Between the groups no statistically significant differences were found. Thus, Suprofen was as effective in pain relief as Naproxen. One patient in the Suprofen group and two patients in the Naproxen group experienced mild gastrointestinal symptoms. Overall tolerability was very good.
mesh_terms: D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D010166:Palliative Care; D010666:Phenylpropionates / Q000627:therapeutic use*; D013496:Suprofen / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010666:Phenylpropionates; D009288:Naproxen; D013496:Suprofen