Transfer of murine experimental autoimmune encephalomyelitis and cell-mediated immunity to myelin protein is effected by Lyt-1 cells.
Cellular transfer of experimental autoimmune encephalomyelitis (EAE) was effected in mice with lymph node cells (LNC) from appropriately immunized donors. Pretreatment of LNC with anti-Lyt-1 and Lyt-2,3 antibodies indicated that the transfer of both EAE and a cell-mediated immune response in vitro to MBP was dependent on a subpopulation of T lymphocytes expressing the phenotype associated with the helper and cell-mediated delayed hypersensitivity functions, Lyt-1+, 2-.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D004679:Encephalomyelitis / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D004676:Myelin Basic Protein / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D004676:Myelin Basic Protein