title: Successful treatment of cold angio-oedema by H2-antihistamine therapy.
abstract: Two patients with severe cold angio-oedema were practically relieved from their symptoms during H2-blocker therapy (cimetidine 1 000 mg daily). Classic H1-blocker therapy had no effect on their symptoms and combined H1- and H2-blocker treatment was just as effective in ameliorating the symptoms of cold angio-oedema as H2-blocker treatment alone. A low dose of the H2-blocker (400 mg cimetidine daily) was almost able to control the angio-oedema formation after cold exposure, but provoked typically urticarial lesions. This observation strongly indicates that H2-receptors may play an important role in the pathogenesis of cold angio-oedema and that a massive, subcutaneous, cold angio-oedema may obscure cold urticarial lesions.
mesh_terms: D000328:Adult; D000799:Angioedema / Q000188:drug therapy* / Q000209:etiology; D002927:Cimetidine / Q000008:administration & dosage*; D003080:Cold Temperature / Q000009:adverse effects; D003533:Cyproheptadine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006146:Guanidines; D003533:Cyproheptadine; D002927:Cimetidine