Type C virus particles produced in human T-cell lines derived from acute lymphoblastic leukemia and a leukemic T-lymphoid malignancy.
Electron microscopy of four human T-cell lines revealed the production of type C virus particles in two T-cell lines: one derived from acute lymphoblastic leukemia and the other from a leukemic T-lymphoid malignancy. Virus particles isolated from these cells had reverse transcriptase activity and the major internal structural protein of 30,000 daltons (p30). The indirect immunofluorescence test of these virus-producing cells with sera of patients with adult T-cell leukemia (ATL) was negative. The data indicate that these retroviruses are different from adult T-cell leukemia virus (ATLV).
D002460:Cell Line; D005455:Fluorescent Antibody Technique; D006801:Humans; D066298:In Vitro Techniques; D007945:Leukemia, Lymphoid / Q000382:microbiology*; D008223:Lymphoma / Q000382:microbiology*; D008854:Microscopy, Electron; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012190:Retroviridae / Q000145:classification / Q000302:isolation & purification*; D013601:T-Lymphocytes / Q000382:microbiology*; D014764:Viral Proteins / Q000032:analysis; D015678:Viral Structural Proteins; D014771:Virion / Q000302:isolation & purification*
D014764:Viral Proteins; D015678:Viral Structural Proteins; D012194:RNA-Directed DNA Polymerase