title: The natural history of isolated congenital pulmonary valve incompetence: surgical implications.
abstract: The natural history of isolated congenital pulmonary valve incompetence has been determined by actuarial and parametric techniques from 72 cases collected from the literature. Symptoms developed within 20 years in 6% (CL 4% to 9%) of the patients and within 40 years in 29% (CL 22% to 36%). The hazard function of the development of symptoms demonstrates a risk increasing in time, particularly evident after 40 years. Death followed the appearance of symptoms after an average of 39 months in 3 patients who died. The surgical implications as regards the use of transannular patches and valveless extracardiac conduits are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008875:Middle Aged; D011665:Pulmonary Valve Insufficiency / Q000151:congenital* / Q000401:mortality / Q000601:surgery; D012306:Risk; D013997:Time Factors