MHC epitopes of KS and Dd restrict the same population of cytolytic T lymphocytes.
When A. SW (H-2S) mice are immunized with B10.S (H-2S) epidermal cells, cytolytic T lymphocytes are evoked that efficiently lyse B10.D2 (H-2d) as well as B10.S target cells. Immunogenetic analysis of this apparent H-2-unrestricted killing revealed that the most plausible explanation was a sharing of an H-2-restricting epitope by H-2KS and H-2Dd molecules.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D007111:Immunity, Cellular; D008285:Major Histocompatibility Complex; D051379:Mice; D011110:Polymorphism, Genetic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes; D006183:H-2 Antigens