Simultaneous occurrence of anti-F1 and anti-I cold agglutinins in a patient's serum.
The second example of anti-F1 cold agglutinins recognizing a developmentally regulated antigen like I is described. The antibody occurred transiently and simultaneously together with an anti-I cold agglutinin. Although anti-F1 and anti-I specificities are entirely different, the data on the biochemistry of F1 and I antigenic determinants provide an explanation for the simultaneous occurrence of anti-F1 and anti-I cold agglutinins in connection with a poly- or oligoclonal autoimmune response.
D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology; D001789:Blood Group Antigens / Q000276:immunology*; D002240:Carbohydrate Sequence; D000939:Epitopes; D006801:Humans; D007048:I Blood-Group System / Q000276:immunology*
D001323:Autoantibodies; D001789:Blood Group Antigens; D000939:Epitopes; D007048:I Blood-Group System