Is predisposition to pemphigus vulgaris in Jewish patients mediated by HLA-Dw10 and DR4?
Twenty-one Israeli Jewish pemphigus vulgaris (PV) patients were studied for the HLA-D lymphocyte defined determinants and the serologically defined antigens of the HLA-A, B, and DR series. HLA-D typing revealed that Dw10 is significantly associated with PV: 86% of patients vs 18% of controls carried Dw10, and DR4 was present in 86% of patients as compared to 38% in the controls. The most striking observation was that all Dw10 positive patients were also positive for DR4, and no other patient carried DR4 alone. The relative risk for a Dw10-DR4 carrier to develop PV was estimated at 31.9, higher than that observed for Dw10 alone (RR 26.7) or DR4 alone (RR 9.6). Probably HLA-Dw10 predisposes for pemphigus vulgaris.
D000939:Epitopes / Q000032:analysis; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007585:Jews; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010392:Pemphigus / Q000235:genetics* / Q000276:immunology
D000939:Epitopes; D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D059811:HLA-DRB1 Chains; C553506:HLA-DRB1*04:02 antigen; D000949:Histocompatibility Antigens Class II