Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid adrenal axis.
Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced the differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.
D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000096:biosynthesis*; D003907:Dexamethasone / Q000494:pharmacology; D007016:Hypophysectomy; D007372:Interferons / Q000096:biosynthesis; D007700:Kinetics; D008198:Lymph Nodes / Q000502:physiology*; D051379:Mice; D009521:Newcastle Disease / Q000378:metabolism*; D013997:Time Factors
D003907:Dexamethasone; D007372:Interferons; D003345:Corticosterone