[Differential effect of bleomycin on squamous epithelium at various sites].
By autoradiographic methods it was examined, whether a specific local effect on squamous epithelium can be proved in a animal model. For this purpose the proliferatory activity was considered in the epithelium of the murine tongue, of esophagus, of the skin in the area of foot and of tail as long as 72 hours after a single application of bleomycin. The result shows, that the proliferatory activity is impaired to a greater extent in the epithelium of the tongue and the esophagus in comparison on the squamous epithelium of foot and tail skin.
D000818:Animals; D001345:Autoradiography; D001761:Bleomycin / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects; D004947:Esophagus / Q000187:drug effects*; D005260:Female; D008938:Mitosis / Q000187:drug effects; D009115:Muridae; D012867:Skin / Q000187:drug effects*; D014059:Tongue / Q000187:drug effects*
D001761:Bleomycin
Unterschiedliche Bleomycin-Wirkung auf Plattenepithel verschiedener Lokalisation.