title: Tumor-associated antigens in female genital tract cancers.
abstract: The immunologic reactivity of glycoprotein antigens extractable from individual, histologically different ovarian and uterine cancers was studied taking into account their relationship with carcinoembryonic antigen (CEA), nonspecific cross-reacting antigen (NCA), alpha-feto-protein (AFP), and alpha-1-antichymotrypsin. All studies were performed using specific immune sera against perchloric acid (PCA) extracts of ovarian mucinous cystadenocarcinoma (anti-PCA-CaOm) and cervical squamous cell carcinoma (anti-PCA-CaCx), and antisera against the reference antigens mentioned above. A considerable antigenic heterogeneity and the existence of several immunologically related antigenic systems were found: 1) CEA-like antigens; 2) NCA-type antigens; 3) an antigen different from CEA and NCA present in ovarian mucinous adenocarcinomas and often cross-reacting, but not identical with respective antigens of uterine body and cervical carcinomas; 4) an antigen reacting with anti-alpha-1-anti-chymotrypsin serum; and 5) an antigen reacting with anti-AFP serum.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D015815:Cell Adhesion Molecules; D002918:Chymotrypsin / Q000032:analysis / Q000037:antagonists & inhibitors; D003429:Cross Reactions; D003536:Cystadenocarcinoma / Q000276:immunology; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology*; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007106:Immune Sera; D007158:Immunologic Techniques; D010051:Ovarian Neoplasms / Q000276:immunology; D014020:Tissue Extracts / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000276:immunology; D014594:Uterine Neoplasms / Q000276:immunology; D000514:alpha 1-Antichymotrypsin; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D007106:Immune Sera; D014020:Tissue Extracts; D000514:alpha 1-Antichymotrypsin; D000509:alpha-Fetoproteins; D002918:Chymotrypsin