Central action of 6-aminodopamine.
6-Aminodopamine (6-ADA) is a dopamine analog causing degeneration of peripheral adrenergic fibers. Given to the lateral cerebral ventricle in mice 6-ADA did not change the locomotor activity of animals. In doses 10-200 micrograms ivc 6-ADA depressed the noradrenaline level only in the cerebral cortex, while the level of dopamine was depressed also in the subcortical nuclei.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D013563:Sympathectomy, Chemical
C006532:6-aminodopamine; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine