title: The effect of an oral combined preparation (antihistamine and decongestant) on Eustachian tube function in the common cold.
abstract: In this randomized double-blind study the effect of an oral, combined preparation (antihistamine + decongestant) on Eustachian tube function was compared with that of placebo in 80 adults with common cold. Tubal patency was measured by sonotubometry and indirectly by tympanometry. Sonotubometry clearly showed the Eustachian tube gradually returning to normal as the infection resolved. The tubal opening measurements revealed a slight tendency towards improved tubal function with the active drug, but the differences between the treated and the placebo group were statistically insignificant.
mesh_terms: D000158:Acoustic Impedance Tests; D000284:Administration, Oral; D000328:Adult; D003139:Common Cold / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004338:Drug Combinations; D005064:Eustachian Tube / Q000503:physiopathology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D014663:Nasal Decongestants / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D004338:Drug Combinations; D006634:Histamine H1 Antagonists; D014663:Nasal Decongestants