Changes in preneoplastic response to aflatoxin B1 in rats fed green beans, beets or squash.
Weanling male Fischer rats were fed diets containing 25% freeze-dried green beans, beets or squash either with or without 1 ppm aflatoxin B1 for 8 wk. Plasma alpha-foetoprotein concentrations were determined weekly from wk 4 to 7. During wk 8 the animals were killed and hepatic sections were stained for gamma-glutamyl transpeptidase. All three vegetable diets, as compared to the basal semi-purified diet, enhanced both aflatoxin-B1-induced elevation of plasma alpha-foetoprotein and aflatoxin-B1-induced emergence of hepatic cell foci of gamma-glutamyl transpeptidase. The data suggest that these vegetables contain natural factors that enhance aflatoxin B1 carcinogenicity.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D004032:Diet; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D014675:Vegetables; D000509:alpha-Fetoproteins / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000032:analysis
D000348:Aflatoxins; D000509:alpha-Fetoproteins; D016604:Aflatoxin B1; D005723:gamma-Glutamyltransferase