Platelet serotonin release in rheumatoid arthritis: a study in food-intolerant patients.
Serotonin and 5-hydroxyindoleacetic acid levels in platelet-rich plasma were determined in serial samples obtained before and up to 6 h after food-challenge in 7 patients showing inflammation of the joints after ingestion of certain foods. Exacerbation of arthritis was associated with a fall in serotonin levels and a subsequent increase in 5-hydroxyindoleacetic acid. These data suggest that serotonin may be released from platelets during food challenges and that platelet serotonin release may contribute to joint inflammation.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D006969:Hypersensitivity, Immediate / Q000097:blood; D008297:Male; D012217:Rheumatoid Factor / Q000032:analysis; D012701:Serotonin / Q000097:blood*; D013583:Synovial Membrane / Q000378:metabolism
D000936:Antigen-Antibody Complex; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D012217:Rheumatoid Factor