Mast cell histamine release induced by doxorubicin and the inhibitory effect of fructose 1,6-diphosphate.
Doxorubicin (DXR) (10(-4) mol/l) causes histamine release from isolated rat mast cells. At lower doses (range 10(-8) mol/l-10(-5) mol/l) the drug failed to evoke secretion. In the 10(-5) mol/l-10(-4) mol/l range there is a significant decrease of the ATP intracellular levels. Fructose 1,6-diphosphate (FDP) produced a sharp increase of the ATP content of the DXR treated cells. In particular, FDP pretreatment inhibited the DXR stimulated histamine release.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D004317:Doxorubicin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005635:Fructosediphosphates / Q000494:pharmacology*; D006598:Hexosediphosphates / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D003189:p-Methoxy-N-methylphenethylamine; D004317:Doxorubicin; D000255:Adenosine Triphosphate; C029063:fructose-1,6-diphosphate