title: Demethylation and auto-oxidation of different cobalt-=bleomycin complexes.
abstract: Demethylation of Co-bleomycin A2 by heating yields three different complexes: form I and form II and "orange" Co-bleomycin-demethyl A2. These complexes can be separated by HPLC and show different 1H NMR spectra. Preparation of Co-bleomycin-demethyl A2 by chelation of bleomycin-demethyl A2 with cobalt yields a Co-bleomycin-demethyl A2, which is auto-oxidized into Co-bleomycin A1.
mesh_terms: D001761:Bleomycin / Q000302:isolation & purification / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction
chemical_list: C030187:cobalt bleomycin; D001761:Bleomycin