Leukotrienes and lipoxygenase factors: mediators and modulators of the allergic reaction.
Lipoxygenase factors of arachidonic acid (mono- and di-Hetes) are not only mediators but also modulators of inflammatory reactions. They have chemotactic and spasmogenic properties; the latter are similar to those induced by the slow reacting-substance of anaphylaxis (SRS-A). The eosinophil chemotactic factor has been identified as a lipoxygenase product. Among the chemically mono- and di-Hetes the 5-S-12-R di-Hete (LTB4) and the 5-S 12S di-Hete demonstrated the most pronounced eosinophil chemotactic activity. The phospholipase-arachidonic acid sequence is involved in the IgE induced activation and secretion of human basophils. With arachidonic acid analogs the lipoxygenase transformation pathway is inhibited.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D001091:Arachidonate Lipoxygenases; D001095:Arachidonic Acids / Q000276:immunology* / Q000378:metabolism; D001491:Basophils / Q000276:immunology; D002631:Chemotactic Factors, Eosinophil / Q000096:biosynthesis / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D006168:Guinea Pigs; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D007975:Leukotriene B4 / Q000276:immunology*; D015289:Leukotrienes; D008084:Lipoxygenase / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D013189:SRS-A / Q000276:immunology*
D001095:Arachidonic Acids; D002631:Chemotactic Factors, Eosinophil; D015289:Leukotrienes; D013189:SRS-A; D007975:Leukotriene B4; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; C025348:arachidonic acid 5-hydroperoxide; D001091:Arachidonate Lipoxygenases; D008084:Lipoxygenase; D010741:Phospholipases A