A study of urinary excretion of biogenic amine metabolites in epilepsy.
Urinary total catecholamines, their metabolites, and a metabolite of serotonin have been investigated in 20 patients with epilepsy, and in 10 controls. The levels of total catecholamines, vanillyl mandelic acid and 5-hydroxyindole acetic acid in epileptics were not significantly different from the controls. However, the mean 3-methoxy-4-hydroxyphenylglycol, excretion in cases of epilepsy was significantly increased as compared to the control group. It is concluded that a central catecholaminergic disturbance is involved in the pathogenesis of epilepsy.
D000293:Adolescent; D000328:Adult; D001679:Biogenic Amines / Q000652:urine*; D004827:Epilepsy / Q000652:urine*; D005260:Female; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D008875:Middle Aged
D001679:Biogenic Amines; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid