Use of recombinant interferon to prevent recurrent herpesvirus shedding.
Iontophoresis with 6-hydroxydopamine was performed in rabbits previously infected with herpes simplex virus, McKrae strain. Viral shedding into the tear film was significantly decreased by the use of recombinant alpha interferon subtype D given as one drop qid. Interferon was noted in the tear film of rabbits 16-18 hours after the last placement of interferon drops into the inferior cul-de-sac.
D000818:Animals; D001082:Aqueous Humor / Q000382:microbiology; D004353:Drug Evaluation, Preclinical; D005260:Female; D005500:Follow-Up Studies; D006892:Hydroxydopamines / Q000627:therapeutic use; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D007372:Interferons / Q000008:administration & dosage / Q000627:therapeutic use*; D007478:Iontophoresis; D007635:Keratitis, Dendritic / Q000517:prevention & control* / Q000628:therapy; D009883:Ophthalmic Solutions; D016627:Oxidopamine; D011817:Rabbits; D012008:Recurrence; D018139:Simplexvirus / Q000187:drug effects / Q000302:isolation & purification; D013666:Tears / Q000382:microbiology; D013997:Time Factors; D014776:Virus Cultivation
D006892:Hydroxydopamines; D007370:Interferon Type I; D009883:Ophthalmic Solutions; D016627:Oxidopamine; D007372:Interferons