Elevated concentrations of substance P and 5-HT in plasma in patients with carcinoid tumors.
Ten patients with metastatic carcinoid tumors in the liver showed elevated 5-hydroxytryptamine and substance P levels in plasma samples taken from hepatic or peripheral veins. Chromatographic characterization of the substance P-immunoreactivity showed that by gel permeation and high pressure liquid chromatography the substance P-immunoreactivity was indistinguishable from synthetic undecapeptide substance P. The results suggest that substance P, in addition to the 5-hydroxyinoles, may serve as a circulatory marker for some forms of carcinoid tumors.
D000368:Aged; D002276:Carcinoid Tumor / Q000097:blood*; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012701:Serotonin / Q000097:blood*; D013373:Substance P / Q000097:blood*
D012701:Serotonin; D013373:Substance P