The effects of the antirheumatic agents N-(2-carboxyphenyl)-4-chloroanthranilic acid disodium (CCA) and D-penicillamine on the NK and ADCC activities and interferon production of lymphocytes.
CCA and D-penicillamine enhanced the NK activity of human lymphocytes in vitro incubation. ADCC activity of the lymphocytes was increased slightly by D-penicillamine but not by CCA. CCA enhanced interferon production from lymphocytes but D-penicillamine did not.
D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007372:Interferons / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D010396:Penicillamine / Q000494:pharmacology*; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D062367:ortho-Aminobenzoates; D007372:Interferons; C015735:lobenzarit; D010396:Penicillamine