Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1.
Myelin-associated glycoprotein (MAG) is a quantitatively minor component in both peripheral and central myelin sheaths that is thought to have a role in cell-cell interactions within the nervous system. We show here that a mouse monoclonal antibody, HNK-1, which is directed against human natural killer cells also recognizes an antigenic determinant of human central and peripheral nervous system white matter by immunoperoxidase staining of tissue sections. Immunoblot analysis of myelin proteins and purified extracted MAG indicates that the antigen recognized is MAG.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008970:Molecular Weight; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein
D000911:Antibodies, Monoclonal; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein