[Experimental model for the detection of leukemia-specific antigens in acute leukemias in humans].
An experimental model for demonstration of leukospecific antigens is offered: immunization of animals with leukemic cells from the same patient followed by examination of antisera and performance of adsorption within the autologous system of the same patients suffering from acute leukemia. It has been found that antigenic spectrum of leukemic cells and lymphocytes within the histoidentical system of the same patient varies: the leukemic cells bear additional antigens on their surface whereas mature lymphocytes had none of them. The lack of possibility to compare additional antigens with differentiating antigens enables one to term them as leuko-associated rather than leukospecific antigens.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis; D000941:Antigens / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007114:Immunization; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008954:Models, Biological
D000912:Antibodies, Neoplasm; D000941:Antigens; D000951:Antigens, Neoplasm; D000961:Antilymphocyte Serum; D000939:Epitopes
Eksperimental'naia model' dlia obnaruzheniia leĭkozospetsificheskikh antigenov pri ostrykh leĭkozakh cheloveka.