Effect of amineptine on the firing rate of central monoaminergic neurons in the rat.
The firing rate of central noradrenergic, serotonergic and dopaminergic neurons was recorded in rats anaesthetized with chloral hydrate. The i.v. perfusion of amineptine decreased the frequency of discharge of noradrenergic and dopaminergic neurons but had no effect on serotonergic cells. Quantitatively amineptine was a more potent inhibitor of dopaminergic than of noradrenergic neurons. These experiments in vivo confirm biochemical studies in vitro reporting a selective action of amineptine on dopaminergic systems.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001679:Biogenic Amines / Q000502:physiology*; D002490:Central Nervous System / Q000187:drug effects*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology
D000928:Antidepressive Agents; D001679:Biogenic Amines; D003986:Dibenzocycloheptenes; C011597:amineptin; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine