Antigenic determinant(s) shared by the human Thy 1 and human IgG.
A human T cell differentiation antigen (p25) previously described as being the mouse theta equivalent has been examined for shared antigenic determinants with immunoglobulin. A strong cross-reactivity of an antiserum prepared against p25 antigen was established with human IgG subclasses. This antiserum does not react with human IgM or IgA, nor with primate immunoglobulins. The shared determinants appear to be associated with the disulphide-bonded cysteines in the first and third constant domains of the IgG molecule and the 9-112 disulfide bond of Thy 1.
D000918:Antibody Specificity; D000954:Antigens, Surface / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D000090266:Chromobox Protein Homolog 5; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D018800:Thy-1 Antigens
D000954:Antigens, Surface; C000715594:CBX5 protein, human; D000939:Epitopes; D007074:Immunoglobulin G; D018800:Thy-1 Antigens; D000090266:Chromobox Protein Homolog 5