Survival and differentiation of oligodendrocytes from neural tissue transplanted into new-born mouse brain.
Fragments of new-born mouse central nervous system have been transplanted into new-born mice host brains, under conditions in which the myelin synthesized by the oligodendrocytes included in the graft, could be distinguished from the host myelin. The work demonstrates that transplanted oligodendrocytes survive in the host brain, migrate out of the graft and synthesize myelin. No sign of rejection was observed during the time of the experiment.
D000818:Animals; D002454:Cell Differentiation; D002470:Cell Survival; D002540:Cerebral Cortex / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008818:Mice, Neurologic Mutants; D004676:Myelin Basic Protein / Q000378:metabolism; D009186:Myelin Sheath / Q000166:cytology; D009416:Nerve Regeneration; D009457:Neuroglia / Q000166:cytology*; D009830:Olfactory Bulb / Q000637:transplantation*; D009836:Oligodendroglia / Q000166:cytology*
D004676:Myelin Basic Protein