title: The effect of isobutylmethylxanthine on the photoresponse and phosphorylation of phosphatidylinositol in octopus retina.
abstract: The effect of isobutylmethylxanthine on the photoresponse and the phosphorylation of phosphatidylinositol was studied. The recovery of photoresponse after a bright flash was greatly altered by the addition of isobutylmethylxanthine. Phosphatidylinositol phosphorylation, assessed by the incorporation of label from [gamma-32P]ATP, was influenced by isobutylmethylxanthine. Incorporation of 32P was decreased into diphosphoinositide and triphosphoinositide, and increased into phosphatidic acid. These changes were interpreted by introducing a parameter, phi, calcium charge of the plasma membrane.
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006152:Cyclic GMP / Q000494:pharmacology; D003624:Darkness; D007700:Kinetics; D008027:Light; D049831:Octopodiformes; D010716:Phosphatidylinositols / Q000378:metabolism*; D010766:Phosphorylation; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D013806:Theophylline / Q000031:analogs & derivatives*
chemical_list: D010716:Phosphatidylinositols; D000255:Adenosine Triphosphate; D013806:Theophylline; D006152:Cyclic GMP; D002118:Calcium; D015056:1-Methyl-3-isobutylxanthine