Effect of chronic alcohol administration on the exocrine pancreas after jejunoileal bypass in the rat.
To determine whether intestinal bypass operation and alcohol administration exerted a synergistic effect on pancreatic enzyme composition and morphology, adult rats were submitted either to a sham-operation or to a 90 per cent jejunoileal bypass. Two weeks after the operation, the rats received a 15 per cent solution of ethanol in drinking fluid during a period of four weeks while controls received water. In sham-operated animals, alcohol had no effect on pancreatic weight or its total content in protein and amylase. The general structural and ultrastructural aspect remained unchanged except for the presence of a few mixed acinar-islet cells. Bypass operation alone induced a significant decrease in amylase content while the population of zymogen granules was reduced. Parallely, lipid droplets deposited within acinar cells. Alcohol administered in bypassed animals exerted a synergistic effect on fat accumulation in pancreatic acinar cells but had no effect on other biochemical and morphological parameters.
D000681:Amylases / Q000032:analysis; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage*; D007082:Ileum / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D009929:Organ Size; D010179:Pancreas / Q000032:analysis / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D010187:Pancreatic Hormones / Q000378:metabolism; D011183:Postoperative Complications; D011506:Proteins / Q000032:analysis; D051381:Rats
D010187:Pancreatic Hormones; D011506:Proteins; D000431:Ethanol; D000681:Amylases