[Various characteristics of the synthesis of nucleic acids and proteins in the prostate of castrated rabbits after separate and successive administration of testosterone and 5 alpha-dihydrotestosterone].
The results are presented of studying nucleic acid and protein synthesis in the rabbit prostate. It was shown that incorporation of radioactive precursors into the prostate DNA, RNA and proteins is diminished two months after gonadectomy of the animals. Testosterone and its metabolite 5 alpha-dihydrotestosterone markedly intensify RNA and protein synthesis in the prostate of castrated rabbits, whereas 5 alpha-dihydrotestosterone only exerts a stimulating effect upon DNA synthesis. Preliminary testosterone propionate injections to gonadectomized rabbits delay DNA synthesis, induced by 5 alpha-dihydrotestosterone, and decrease the marker incorporation into RNA and protein, comparatively to the effect of each separate androgen.
D000818:Animals; D002369:Castration; D004247:DNA / Q000096:biosynthesis*; D013196:Dihydrotestosterone / Q000008:administration & dosage*; D004347:Drug Interactions; D008297:Male; D011467:Prostate / Q000378:metabolism*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D011817:Rabbits; D013739:Testosterone / Q000008:administration & dosage*
D013196:Dihydrotestosterone; D013739:Testosterone; D012313:RNA; D004247:DNA
Nekotorye osobennosti sinteza nukleinovykh kislot i belka v predstatel'noĭ zheleze kastrirovannykh krolikov pri razdel'nom i posledovatel'nom vvedenii testosterona 5 alpha-digidrotestosterona.