title: [Immunoglobulin M and alpha 2-macroglobulin in the amniotic fluid in neural tube defects].
abstract: Alpha 1-fetoprotein (AFP), alpha 2-macroglobulin (AMG) and immunoglobulin M (IgM) were estimated quantitatively in 16 amniotic fluid samples of gestational weeks 15 to 21. In 4 pregnancies there were defects of the neural canal (2 anencephalic fetuses, 2 fetuses with meningomyelocele). The other 12 amniotic fluid samples from normal pregnancies are used as control group. AFP, AMG and IgM concentrations were increased in the 4 pathologic samples. AFP was detected using Laurell-technique, AMG and IgM by single radial immunodiffusion.
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D000757:Anencephaly / Q000378:metabolism*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D008591:Meningomyelocele / Q000378:metabolism*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D000509:alpha-Fetoproteins / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism*
chemical_list: D007075:Immunoglobulin M; D000509:alpha-Fetoproteins; D000511:alpha-Macroglobulins
vernacular_title: Immunglobulin M und alpha 2-Makroglobulin im Fruchtwasser bei Neuralrohrdefekten.