title: Some effects of 1-(2,4-Dichlorophenyl)-4-dimethylamino-methyl-1-nonen-3-one hydrochloride on Escherichia coli GK-19.
abstract: 1-(2,4-Dichlorophenyl)-4-dimethylaminomethyl-1-nonen-3-one hydrochloride (Id) was shown to inhibit the growth of Escherichia coli GK-19 at a concentration of 50 micrograms/mL in a medium of pH 6.5. Maximal antibacterial activity was found during the logarithmic growth phases rather than at the early stationary phase. Electron microscopy revealed that Id caused lysis, and inhibition of respiration and retardation of RNA and protein syntheses occurred in the bacteria with this compound at 50 micrograms/mL.
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D004269:DNA, Bacterial / Q000096:biosynthesis; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004123:Dimethylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D010101:Oxygen Consumption / Q000187:drug effects; D012329:RNA, Bacterial / Q000096:biosynthesis; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004123:Dimethylamines; D012329:RNA, Bacterial; D002701:Chloramphenicol; C041985:1-(2,4-dichlorophenyl)-4-dimethylaminomethyl-1-nonen-3-one; D004121:Dimethyl Sulfoxide