[Biological effect of bestatin against rat ascites hepatomas and enhancement of interferon production].
Biological effect of bestatin against rat ascites hepatomas was investigated. Bestatin administration inhibited effectively growth of AH 130, AH 44 and AH 66, and prolonged survival days of the tumor-bearing rats. In addition bestatin slightly exhibited interferon production in spleen cells from ddY mice in vitro.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology / Q000627:therapeutic use*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D005260:Female; D007369:Interferon Inducers / Q000627:therapeutic use*; D007372:Interferons / Q000096:biosynthesis; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D000903:Antibiotics, Antineoplastic; D007369:Interferon Inducers; D007372:Interferons; D007930:Leucine; C012211:ubenimex