The IgA response: inductive aspects, regulatory cells, and effector functions.
In this review, we have emphasized our current studies on the inductive aspects of the IgA immune response and homeostatic mechanisms involved in the induction of oral tolerance. By use of unique inbred mouse strains in restricted microbial environments, we have provided evidence for a central role of LPS in systemic unresponsiveness to orally encountered antigens. We have continued studies on characterization of GALT lymphoreticular cell types, including accessory cells, regulatory T-cells, and precursor IgA B-cells. We have placed recent emphasis on characterization of antigen-specific Th-cell clones derived from murine PP, which preferentially support IgA isotype responses. Relevant areas for continued research have been emphasized in this review.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D000939:Epitopes; D006825:Hybridomas / Q000276:immunology; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D007519:Isoantigens / Q000008:administration & dosage; D008070:Lipopolysaccharides / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010581:Peyer's Patches / Q000276:immunology; D051381:Rats; D011916:Rats, Inbred F344; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000911:Antibodies, Monoclonal; D000939:Epitopes; D007070:Immunoglobulin A; D007519:Isoantigens; D008070:Lipopolysaccharides