title: Blood group A antigen site distribution and immunoglobulin binding in relation to red cell age.
abstract: Heterogeneity of alpha antigen site density was demonstrated on individual human A1 and A2 type red cells by immunoelectronmicroscopy using haemocyanin-conjugated antiglobulin. Examination of red cells fractionated on a Percoll density gradient showed that the heterogeneity was not age-related. The presence of autologous immunoglobulin on senescent red cells was also confirmed by the same technique.
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D001666:Binding Sites, Antibody; D002499:Centrifugation, Density Gradient; D000939:Epitopes / Q000032:analysis*; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000276:immunology / Q000648:ultrastructure; D005613:Freeze Etching; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008854:Microscopy, Electron; D011188:Potassium / Q000097:blood
chemical_list: D000017:ABO Blood-Group System; D000939:Epitopes; D007136:Immunoglobulins; D011188:Potassium