Retrograde transport of [3H]proline: a widespread phenomenon in the central nervous system.
[3H]Proline was injected into spinal cord, pons, inferior colliculus, superior colliculus, lateral geniculate nucleus, pulvinar-LP complex and visual cortex of cats or rats. After 1-3 days' survival the animals were perfused with formalin or mixed aldehydes. Autoradiography showed labeling of cell bodies in most regions known to project to the injection sites. The ability to take up and retrogradely transport [3H]proline appears to be a common property of central neurons. We infer that the transport of this compound is unrelated to its possible status as a neurotransmitter.
D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport; D001921:Brain / Q000502:physiology*; D002415:Cats; D004525:Efferent Pathways / Q000502:physiology*; D009928:Organ Specificity; D011392:Proline / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord / Q000502:physiology*; D014316:Tritium
D014316:Tritium; D011392:Proline