Differential sensitivity to ethidium bromide of replicative DNA synthesis and bleomycin-induced unscheduled DNA synthesis in permeable mouse sarcoma cells.
Replicative DNA synthesis in permeable mouse sarcoma cells was more sensitive to ethidium bromide (EtBr) than bleomycin-induced unscheduled DNA synthesis (UDS). A similar difference in sensitivity to EtBr was observed between DNA polymerases alpha and beta. The difference in sensitivity to EtBr of replicative DNA synthesis and UDS in the present system seems to reflect mainly the sensitivity difference between DNA polymerases alpha and beta.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis*; D004256:DNA Polymerase I / Q000037:antagonists & inhibitors; D004257:DNA Polymerase II / Q000037:antagonists & inhibitors; D004261:DNA Replication / Q000187:drug effects*; D004996:Ethidium / Q000494:pharmacology*; D051379:Mice; D012513:Sarcoma, Experimental / Q000378:metabolism*
D001761:Bleomycin; D004247:DNA; D004256:DNA Polymerase I; D004257:DNA Polymerase II; D004996:Ethidium