[The remission of extensive cancers of the mouth and oropharynx with intra-arterial polychemotherapy with vincristine, methotrexate, bleomycin, cisplatin (VMBP)].
Initial intra-arterial chemotherapy was performed during a therapy course in 21 patients with squamous cell carcinoma of the oral cavity and oropharynx, including chemotherapy, operation, and radiation. A combination of Vincristine, Methotrexate, Bleomycin, and Cisplatin (VMBP) was administered. The aim of this initial therapy was to reduce the tumour mass. 10 patients showed complete clinical remission. In 5 of these no malignant cells could be found on histological examination of the primary site of the tumour.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007261:Infusions, Intra-Arterial; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D010610:Pharyngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001761:Bleomycin; D014750:Vincristine; D002945:Cisplatin; D008727:Methotrexate
Die Remission ausgedehnter Karzinome der Mundhöhle und des Oropharynx unter intraarterieller Polychemotherapie mit Vincristin, Methotrexat, Bleomycin, Cisplatin (VMBP).