Preservative activity in diluted corticosteroid creams.
The preservative efficacy of both 'Betnovate' and 'Synalar' creams diluted 1:1 with 'Unguentum Merck' was investigated. Each formulation was challenged with Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa at an initial inoculum level of approximately 1 X 10(6) viable organisms per gram of cream. All formulations tested were found to be effectively preserved against the organisms used and no viable bacteria were detected 7 days after inoculation.
D001419:Bacteria / Q000187:drug effects*; D001623:Betamethasone / Q000031:analogs & derivatives*; D001624:Betamethasone Valerate / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005446:Fluocinolone Acetonide / Q000494:pharmacology*; D009824:Ointments; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D009824:Ointments; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D005446:Fluocinolone Acetonide; D001623:Betamethasone; D001624:Betamethasone Valerate