Muscle sarcoplasmic reticulum antigen shared by a Trypanosoma cruzi clone.
The results reported here show that a clone of a South American Trypanosoma cruzi human isolate has an epitope antigenically related to sarcoplasmic reticulum adenosine triphosphatase preparations (SRA), an enzyme implicated in the contraction-relaxation cycle of striated muscle. The antigenic determinant of T. cruzi, which is cross-reactive with SRA, is located in the interior of the parasite. No surface cross-reaction was detected with intact, freely swimming flagellates. Indeed, the degree of cross-reactivity was increased when T. cruzi microsomes were trypsinized, probably resulting in further exposure of the normally internal cross-reactive epitope.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D002417:Cattle; D002645:Chickens; D002999:Clone Cells / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis*; D006041:Goats; D000882:Haplorhini; D006385:Hemagglutination Inhibition Tests; D051379:Mice; D008861:Microsomes / Q000276:immunology; D009132:Muscles / Q000276:immunology*; D009206:Myocardium / Q000276:immunology; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000276:immunology*
D000941:Antigens; D000939:Epitopes