Competition between ABO and Le gene specified enzymes. II. Quantitative analysis of A and B antigens in saliva of ABH nonsecretors.
One B- and two A-specific radioimmunoassays detected A and B antigenic determinants in saliva of ABH nonsecretors. The A or B antigens found in saliva of nonsecretors had lower efficiency and higher heterogeneity, in the inhibition of the A or B assays, as compared to A or B antigens in saliva of ABH secretors. In the 3 assays, samples of nonsecretor Lewis positive donors (Lea) had less A or B antigens than samples of nonsecretor Lewis negative donors (Lec), suggesting that there is a competition between A or B and Le gene-specified products.
D000017:ABO Blood-Group System / Q000235:genetics*; D001667:Binding, Competitive; D000939:Epitopes / Q000032:analysis; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000235:genetics*; D011863:Radioimmunoassay; D012463:Saliva / Q000032:analysis* / Q000276:immunology
D000017:ABO Blood-Group System; D000939:Epitopes; D007983:Lewis Blood Group Antigens