Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide.
A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide.
D000914:Antibodies, Viral / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D055598:Chemical Phenomena; D002621:Chemistry; D000939:Epitopes; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D010455:Peptides / Q000276:immunology
D000914:Antibodies, Viral; D000939:Epitopes; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D007130:Immunoglobulin Idiotypes; D010455:Peptides