[Substance P inhibition of the activity of the angiotensin-converting enzyme from human blood serum].
Substance "P" (SP) and its derivatives inhibited activity of angiotensin-converting enzyme (ACE) in human blood serum, I50 for SP was 31 microM. The same results were obtained for N-terminal fragments of the SP molecule: Arg-Pro-Lys-Pro and Lys-Pro. The C-terminal heptapeptide and the dipeptide Arg-Pro negligibly inhibited ACE activity. A possible significance of the interaction between SP and ACE in the regulation of the microhemodynamics is discussed.
D000806:Angiotensin-Converting Enzyme Inhibitors; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D010446:Peptide Fragments; D013373:Substance P; D007703:Peptidyl-Dipeptidase A
Podavlenie veshchestvom "P" aktivnosti angiotenzinprevrashchaiushchego fermenta iz syvorotki krovi cheloveka.