Sensitivity of tryptophan, tyrosine and phenylalanine mutants of Saccharomyces cerevisiae to phenethyl alcohol.
Phenethyl alcohol inhibits the growth of many microorganisms. It is believed that the growth inhibition is mediated by its effect on the cell membrane. Differences between sensitive and resistant strains are suggested to be due to alterations in membrane structure. We report that, in some strains, an unexpected relationship exists between auxotrophy for tryptophan, tyrosine and phenylalanine and sensitivity to phenethyl alcohol.
D000431:Ethanol / Q000031:analogs & derivatives*; D009154:Mutation; D010649:Phenylalanine / Q000235:genetics*; D010626:Phenylethyl Alcohol / Q000633:toxicity*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*; D013045:Species Specificity; D014364:Tryptophan / Q000235:genetics*; D014443:Tyrosine / Q000235:genetics*
D000431:Ethanol; D014443:Tyrosine; D010649:Phenylalanine; D014364:Tryptophan; D010626:Phenylethyl Alcohol