Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes.
Following immunization with PPS, there is a transient but considerable enrichment in the peripheral blood of activated PPS-specific B cells. The activated cells are large, 4F2 positive, surface IgG positive and IgD negative, responsive to BCGF but refractory to anti-mu or SAC. The analysis of B lymphocyte physiology in terms of activation states which have precise signal requirements for the transition between these states should contribute to our further understanding of both normal and abnormal B cell function.
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002469:Cell Separation; D000939:Epitopes / Q000276:immunology; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D015847:Interleukin-4; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000494:pharmacology; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D012397:Rosette Formation; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000939:Epitopes; D006133:Growth Substances; D008222:Lymphokines; D011135:Polysaccharides, Bacterial; D015847:Interleukin-4