Release of platelets into the circulation induced by gamma globulin treatment in a case of idiopathic thrombocytopenic purpura.
The kinetics and distribution in vivo of 111In-labelled platelets prior to and during intravenous high-dose gamma globulin therapy in a 3-months-old child with idiopathic thrombocytopenic purpura were evaluated. Concomitantly with a prompt increase in platelet concentration we found evidence for release of platelets into the circulation, presumably to a large extent originating from the spleen and liver. Our results support the concept that, in response to high-dose gamma globulin therapy, platelets are not only forced to remain in but are also released into the circulation, presumably as a result of mobilization of platelets adhering to cells of the monocyte-macrophage system.
D001792:Blood Platelets / Q000000981:diagnostic imaging / Q000187:drug effects*; D001803:Blood Transfusion; D001856:Bone Marrow Examination; D017707:Erythrocyte Transfusion; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D017713:Platelet Transfusion; D011696:Purpura, Thrombocytopenic / Q000628:therapy*; D011877:Radionuclide Imaging; D005719:gamma-Globulins / Q000627:therapeutic use*
D005719:gamma-Globulins