Immunomodulatory activity of isoprinosine on experimental viral infections in avian models.
The immunomodulatory activity of Isoprinosine treatments have been experimentally verified on chicken infected by three different viruses: Newcastle disease, fowl plague and avian infectious bronchitis. In protection tests, positive variations in the mean day of death rather than in the mortality rate were found depending on the modality of treatment. A stimulatory influence on primary anti-Newcastle disease virus antibody response was observed. In the avian model the Isoprinosine antiviral effect appears as due mainly to the enhancement of interferon production and to a synergistic interferon-isoprinosine interaction.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002645:Chickens; D006385:Hemagglutination Inhibition Tests; D001351:Infectious bronchitis virus / Q000276:immunology; D009980:Influenza A virus / Q000276:immunology; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D007372:Interferons / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D009522:Newcastle disease virus / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology; D014777:Virus Diseases / Q000188:drug therapy / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007288:Inosine; D007372:Interferons; D007542:Inosine Pranobex