Tumour marker acquisition in the polyp-to-cancer sequence in the colon.
Sequential studies of 6 tumour markers in an adenomatous polyp which eventually metastesized as adenocarcinoma are described. The findings suggest that with the development of malignancy, clones of cells with an increasing number of markers are favoured for continued growth and that this probably represents progressive gene derepression.
D000230:Adenocarcinoma / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003110:Colonic Neoplasms / Q000032:analysis* / Q000473:pathology; D006801:Humans; D007417:Intestinal Polyps / Q000032:analysis* / Q000473:pathology; D010928:Placental Lactogen / Q000032:analysis; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D011268:Pregnancy-Specific beta 1-Glycoproteins; D000509:alpha-Fetoproteins; C030139:colon-specific antigen; D010928:Placental Lactogen; D000469:Alkaline Phosphatase