[Effect of +Gx acceleration and adeturon on the nucleic acid content and other indices of the peripheral blood of mice].
The effect of acceleration and adeturon, a radioprotector, on the content of nucleic acids, the count, composition and osmotic resistance of white and red blood cells was investigated. Male mice of the H strain were exposed to +20 Gx for 5 min. The above parameters were measured 1, 24 and 48 hrs after the exposure. The nucleic acid content decreased significantly immediately after the exposure and tended to return to normal afterwards. The leucocyte count was increased during all observation periods, and the erythrocyte count was decreased 1 hr after the exposure. Osmotic resistance of white and red blood cells varied in a different manner after the exposure. Adeturon administered at optimal protective doses (300 mg/kg) modified regulatory mechanisms of the animal body.
D000054:Acceleration / Q000009:adverse effects*; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001769:Blood / Q000187:drug effects*; D004247:DNA / Q000097:blood*; D006112:Gravitation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012313:RNA / Q000097:blood*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D000338:beta-Aminoethyl Isothiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D012313:RNA; C012704:Adeturon; D000255:Adenosine Triphosphate; D004247:DNA
Vliianie uskoreniia +Gx i adeturona na soderzhanie nukleionovykh kislot id drugie pokazateli perifericheskoĭ krovi u mysheĭ.