[Interferon inhibits transformation of mouse tk- cells by a recombinant plasmid carrying the thymidine kinase gene].
Thymidine kinase deficient L cells treated by interferon become resistant to transformation by a recombinant plasmid carrying the herpes virus tk gene. The number of colonies appearing after transformation is inversely proportional to the interferon concentration.
D000818:Animals; D006564:Herpesviridae / Q000235:genetics; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D010957:Plasmids / Q000187:drug effects*; D011995:Recombination, Genetic; D013937:Thymidine Kinase / Q000235:genetics*; D014170:Transformation, Genetic / Q000187:drug effects*
D007372:Interferons; D013937:Thymidine Kinase
L'interféron inhibe la transformation de cellules murines tk- par un plasmide recombinant contenant le gène thymidine kinase.