[Combined action of a specific vaccine, exogenous interferon and an interferon inducer on the development of acute experimental encephalomyelitis].
Comparative studies of the effectiveness of specific vaccine, exogenous interferon, and interferon inducer poly I:C in mice experimentally infected with human acute encephalomyelitis (HAE) virus showed the interferon inducer poly(I) X poly(C) to exert the highest protective activity (up to 72.5% protection). Irrespective of the inoculation route (intraperitoneal, intramuscular, intravenous), the vaccine in combination with interferon or interferon inducer poly(I) X poly(C) produced a considerably higher level of protection of mice (78.5%) against fatal infection with HAE virus than each of the preparations used alone. Studies of the humoral and cellular immunity reactions showed that increased protection levels after the combined use of interferon inducer and vaccine were due to interferon production and activation of the mechanisms of cellular antiviral immunity.
D000208:Acute Disease; D000818:Animals; D002464:Cell Migration Inhibition; D004668:Encephalitis Viruses / Q000276:immunology*; D004679:Encephalomyelitis / Q000276:immunology / Q000517:prevention & control*; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007369:Interferon Inducers / Q000008:administration & dosage*; D007372:Interferons / Q000008:administration & dosage*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D011070:Poly I-C / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*
D007136:Immunoglobulins; D007369:Interferon Inducers; D014765:Viral Vaccines; D007372:Interferons; D011070:Poly I-C
Kombinirovannoe deĭstvie spetsificheskoĭ vaktsiny, ékzogennogo interferona i induktora interferona na razvitie ostrogo éntsefalomielita v éksperimente.