Immunological properties of 3-morpholine-2-hydroxypropyl ether of dextran (H-2).
The immunobiological investigations of H-2 preparation--a modified derivative of DEAE dextran--revealed that the preparation has a wide immunotropic spectrum with the predominance of the stimulatory effect. It stimulates the I and II humoral immunological responses to SRBC. It stimulates the induction and effector processes of the cellular type reactions. Under the in vivo and in vitro conditions it causes mouse precursor T cells to gain the theta antigen. On the other hand, H-2 preparation suppresses the development of GvH reaction induced either by the administration of cells coming from the donor treated with the preparation (in vivo), or by the incubation of the donor's cells with the compound under examination. H-2 preparation is non-toxic, and does not exhibit any antiviral or interferogenic activity.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001323:Autoantibodies / Q000276:immunology; D002460:Cell Line; D002478:Cells, Cultured; D003637:DEAE-Dextran / Q000031:analogs & derivatives; D003911:Dextrans / Q000276:immunology* / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D005909:Glioblastoma / Q000276:immunology; D006087:Graft vs Host Reaction / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007372:Interferons / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains
D001323:Autoantibodies; D003911:Dextrans; C041054:3-morpholine-2-hydroxypropyl dextran ether; D007372:Interferons; D003637:DEAE-Dextran