title: Effect of disodium cromoglycate and cyclic AMP-active drugs on cytotoxic histamine release from rat mast cells.
abstract: Disodium cromoglycate and compounds which elevated levels of cyclic AMP in the mast cell variously inhibited cytotoxic histamine release induced by the surface active agents melittin, Tween 20 and Triton X-100. These results are inconsistent with the postulated effects of the drugs on receptor mediated calcium channels and alternative explanations of their action are considered.
mesh_terms: D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000242:Cyclic AMP; D004205:Cromolyn Sodium