The induction of enhanced glucosamine incorporation into the cell-envelope of Escherichia coli K-12 by the antibiotic tetaine.
The dipeptide antibiotic tetaine and its C-terminal aminoacid-anticapsin are powerfull inhibitors of glucosamine-synthetase EC 5.3.1.19 activity in cell-free extract from Escherichia coli K-12. Tetaine strongly inhibits the incorporation of diaminopimelic acid into the peptidoglycan of bacteria. In media with carbon source other than glucose tetaine induced of enhanced glucosamine incorporation into the cell-envelope of Escherichia coli K-12. Compounds from cell-envelope with enhanced labeled glucosamine contents are solubilisable by pronase treatment.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D005944:Glucosamine / Q000378:metabolism*; D007700:Kinetics; D008070:Lipopolysaccharides / Q000096:biosynthesis*; D010457:Peptidoglycan / Q000096:biosynthesis*; D014316:Tritium
D000900:Anti-Bacterial Agents; D004151:Dipeptides; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D014316:Tritium; C006674:bacilysin; D005944:Glucosamine