Effect of pilocarpine and substance P on ganglionic transmission.
The effect of pilocarpine and substance P on the amplitudes of the postganglionic compound action potentials (unconditioned response, UR and post-train conditioned response, PTR) were studied in the isolated rabbit superior cervical ganglion (SCG). Pilocarpine (50 microM) and substance P (1 microM) produced an increase in the amplitudes of both UR & PTR responses in the rabbit SCG. Facilitation and subliminal fringe values decreased. It was concluded that both pilocarpine and substance P increase the amplitudes of the transmitted postganglionic compound action potentials and they may facilitate ganglionic transmission in the rabbit SCG.
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D010862:Pilocarpine / Q000494:pharmacology*; D011817:Rabbits; D013373:Substance P / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D010862:Pilocarpine; D013373:Substance P