Five antidepressant treatments in depressed patients. Effects on urinary serotonin and 5-hydroxyindoleacetic acid output.
The 24-hour urinary serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) outputs were repeatedly measured in 21 patients with major affective disorders after a minimum of three weeks free of drug treatments and at steady state during subsequent antidepressant treatments or during the second week after a series of electroconvulsive treatments (ECTs). The 5-HIAA outputs were more variable over time than the outputs of major catecholamine metabolites, previously studied by us. Patients with rapid mood cycles excreted large amounts of 5-HT. Lithium carbonate and ECTs reduced the outputs of 5-HT and 5-HIAA, respectively. Lithium carbonate also stabilized the output of 5-HT. No common effect of different antidepressant treatments on indole outputs was found.
D000928:Antidepressive Agents / Q000627:therapeutic use*; D003010:Clorgyline / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology / Q000652:urine; D003891:Desipramine / Q000627:therapeutic use; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D008094:Lithium / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012701:Serotonin / Q000652:urine*; D015031:Zimeldine / Q000627:therapeutic use
D000928:Antidepressive Agents; D010919:Placebos; D016651:Lithium Carbonate; D012701:Serotonin; D015031:Zimeldine; D006897:Hydroxyindoleacetic Acid; D008094:Lithium; D003010:Clorgyline; D003891:Desipramine