Acute organophosphate poisoning presenting with choreo-athetosis.
Although it is known that extrapyramidal function is dependent upon a balance between cholinergic and dopaminergic effects, only anti-dopaminergic substances commonly induce extrapyramidal symptoms. This paper describes a patient who ingested chlorpyrifos and presented with choreo-athetosis and depressed cholinesterases. She responded to atropine therapy and made a complete recovery. Although not often described excessive cholinergic activity may also produce extrapyramidal symptoms.
D000328:Adult; D001285:Atropine / Q000627:therapeutic use; D004390:Chlorpyrifos / Q000506:poisoning*; D002802:Cholinesterases / Q000097:blood; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000503:physiopathology*; D005116:Extrapyramidal Tracts / Q000187:drug effects; D005260:Female; D006801:Humans
D001285:Atropine; D002802:Cholinesterases; D004390:Chlorpyrifos