CSF cortisol in patients with depression, mania, or anorexia nervosa and in normal subjects.
The authors studied CSF cortisol in 30 depressed patients, 10 manic patients, 21 women with anorexia nervosa, and 22 normal control subjects. All patients were also rated on a global severity scale for mania or depression. Results indicated higher CSF cortisol levels in all three patient groups than in the control group. Only the depressed group had a significant positive correlation between CSF cortisol and severity ratings. The authors recommend further research into the hypothalamic mechanisms associated with cortisol secretion and regulation.
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000134:cerebrospinal fluid*; D000856:Anorexia Nervosa / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000134:cerebrospinal fluid* / Q000502:physiology; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007031:Hypothalamus / Q000503:physiopathology; D008297:Male
D006897:Hydroxyindoleacetic Acid; D006854:Hydrocortisone