title: Inhibitory effect of polynucleotides on solid tumor produced in mice by Ehrlich ascites cancer cells.
abstract: Solid tumors produced in mice by Ehrlich ascites cancer cells were completely regressed by treatment with the copolymer of polyriboinosinic acid-polyribocytidylic acid (poly (I):(C)) when 200 microgram of this compound was intravenously injected 3 times a week for 3-4 weeks, starting 7-8 days after transplantation of the tumor. Although the first injection of poly (I):(C) caused hyporeactivity to re-induction of IFN, the subsequent 6 doses stimulated the formation of IFN at 3685 units/ml on average after each injection, strongly suggesting that IFN plays a role in the antitumoral effect of poly (I):(C).
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007372:Interferons / Q000096:biosynthesis; D008297:Male; D051379:Mice; D011070:Poly I-C / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D007372:Interferons; D011070:Poly I-C