Acquisition of tolerance to the antiproliferative activity of interferon by X-ray transformed C3H/10T1/2 cells under prolonged treatment with interferon.
X-ray-transformed C3H/10T1/2 cells serially passaged in the presence of highly purified mouse interferon appeared to acquire progressively a tolerance to the inhibitory effect of interferon on cell proliferation. In contrast, these cells did not appear to develop a tolerance to the antiviral activity of interferon. These results suggest the possibility that these two effects of interferon are mediated by different mechanisms.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004361:Drug Tolerance; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D014965:X-Rays
D007372:Interferons