Antigenic variants of leptospiras detected in peritoneal cavity in early stage of infection in immunized guinea pigs.
Antigenic variants were detected firstly 7 h following intraperitoneal challenge with Leptospira interrogans serovar copenhageni Shibaura in the peritoneal cavity of guinea pigs which had been previously immunized with the homologous strain. The variants appeared at a rate of 63% of the leptospiras which survived in the peritoneal cavity, and the survivors' rate was 0.00005% of the inoculated organisms. The antigenicity of these variants reversed to that of the parent after 3-5 passages in liquid normal serum medium.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001202:Ascitic Fluid / Q000382:microbiology*; D000939:Epitopes; D005260:Female; D014644:Genetic Variation; D006168:Guinea Pigs; D007114:Immunization; D007921:Leptospira interrogans / Q000235:genetics / Q000276:immunology*; D011233:Precipitin Tests; D013997:Time Factors
D000942:Antigens, Bacterial; D000939:Epitopes