Langerhans cells and their precursors with S100 protein in mycosis fungoides.
Twenty-four cases of mycosis fungoides and two cases of Sézary's syndrome were studied with special reference to the infiltration and proliferation of Langerhans cells stained with anti-S100 protein antibody. The number of S100+ histiocytes (Langerhans cells and their precursors) ranged from 104 to 345 (average 188) per 1,000 lymphoid cells in the erythematous and plaque stages, while it decreased to 4-71 (average 34) per 1,000 lymphoid cells in the tumor stage. Conversely, the number of lymphoid cells averaged 6 and 10 per S100+ histiocyte in the erythema and plaque stages, respectively, while it increased to 21.0 per S100+ histiocyte in the tumor stage. The mitotic index of lymphoid cells correlated with the lymphocyte/S100+ histiocyte ratio. A small number of S100+ histiocytes in mycosis fungoides indicated poor prognosis.
D000328:Adult; D000368:Aged; D002452:Cell Count; D005260:Female; D006644:Histiocytes / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007801:Langerhans Cells / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000032:analysis / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis*; D012751:Sezary Syndrome / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology*; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000032:analysis
D009418:S100 Proteins