[Excretion of normal and modified RNA catabolites and creatinine in the urine as a function of nutrition in children].
The urinary excretion of 5 modified and 2 unmodified RNA catabolites and of creatinine has been investigated in two children aged 71/2 and 6 years under different isocaloric diets over 5 days each (phase I-III) and compared with the excretion values during a 12-day and libitum food intake (phase 0). On a diet (phase I) extremely rich in nucleic acids (meat) there is only a slight increase of the modified RNA catabolites and a pronounced increase of creatinine in urine. On a protein-rich diet free from nucleic acids (phase II) the urinary RNA catabolites largely parallel the values seen under ad libitum food intake. On a diet virtually free of nucleic acids and protein (phase III) there is a markedly decreased excretion of modified RNA catabolites. It is concluded that modified RNA catabolites in the urine are mainly of endogenous origin. These "one-way catabolites" permit an assessment of the RNA turnover. Thus, they can serve as a new sensitive biochemical criterion for anabolic and catabolic situations, respectively.
D000225:Adenine / Q000652:urine*; D000704:Analysis of Variance; D002648:Child; D003404:Creatinine / Q000652:urine*; D004044:Dietary Proteins; D005260:Female; D006147:Guanine / Q000378:metabolism / Q000652:urine*; D006801:Humans; D008297:Male; D009705:Nucleosides / Q000652:urine*; D009747:Nutritional Physiological Phenomena; D011560:Pseudouridine / Q000652:urine*; D012313:RNA / Q000378:metabolism*; D014529:Uridine / Q000031:analogs & derivatives*
D004044:Dietary Proteins; D009705:Nucleosides; D011560:Pseudouridine; D006147:Guanine; D012313:RNA; D003404:Creatinine; D000225:Adenine; D014529:Uridine
Die Ausscheidung normaler und modifizierter RNA-Kataboliten sowie von Kreatinin im Urin in Abhängigkeit von der Ernährung bei Kindern.