title: [Effect of multiple gamma globulin administration on the effectiveness of seroprophylaxis in hepatitis A].
abstract: The data provided by immunological and epidemiological studies carried out to determine the influence of the multiple injections of 10% commercial gamma globulin on the level of antigamma globulin formation and, in this connection, on the effectiveness of the prophylaxis of hepatitis A are discussed. A sharp increase in the titers of antigamma globulin in persons receiving multiple gamma globulin injections is shown. The increased amount of antibodies to gamma globulin, appearing as the result of the multiple use of this preparation, decreases the effectiveness of the seroprophylaxis of hepatitis A.
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D006506:Hepatitis A / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D008097:Lithuania; D013997:Time Factors; D014610:Uzbekistan; D005719:gamma-Globulins / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D005719:gamma-Globulins
vernacular_title: Vliianie mnogokratnogo vvedeniia gamma-globulina na éffektivnost' seroprofilaktiki gepatita A.