title: Substance P evokes slow and fast responses in cultured myenteric neurons of the guinea pig.
abstract: Intracelluar electrical recordings were made from myenteric neurons in tissue culture. Most of the neurons were found to be very sensitive to substance P (SP), which was applied by pressure from micropipettes. SP evoked two different responses: slow depolarizations with latencies of 1-5 s and durations of 1-2 min, and fast depolarizations with latencies of 30-50 ms and durations of 1-10 s. These may represent two distinct response mechanisms to SP.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D009197:Myenteric Plexus / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D012701:Serotonin; D013373:Substance P