[Inhibition of platelet aggregation and cyclic nucleotide phosphodiesterase (specifically cyclAMP) by 3-hydroxypyridine derivatives].
The effects of 3-hydroxypyridine (3-HP) derivatives on platelet aggregation and platelet phosphodiesterase (PDE) of cyclic nucleotides (cAMP-dependent) were studied. It was shown that some derivatives of 3-HP inhibit platelet aggregation (the most pronounced effect was exerted by 2-benzyl-3- oxypyridine ). Several derivatives o 3-HP given in a concentration 10(-3) M were discovered to inhibit PDE by 40 to 75%. No correlation was found between the efficacy of 3-HP as antiaggregation agents and PDE inhibitors.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D001241:Aspirin / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D011730:Pyridoxal / Q000494:pharmacology; D011732:Pyridoxal Phosphate / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D011725:Pyridines; D011730:Pyridoxal; C023500:3-hydroxypyridine; D011732:Pyridoxal Phosphate; D013806:Theophylline; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D001241:Aspirin; D015056:1-Methyl-3-isobutylxanthine
Tormozhenie agregatsii i ingibirovanie fosfodiésterazy tsiklicheskikh nukleotidov (spetsifichnoĭ dlia tsAMF) trombotsitov proizvodnymi 3-oksipiridina.