Hereditary abnormalities of the OKT4 human lymphocyte epitope in two families.
The lymphocytes of two unrelated black individuals exhibited no immunofluorescent staining by a monoclonal antibody, OKT4, that reacts with T helper/inducer cells, but the lymphocytes reacted normally with four other monoclonal antibodies that identify T helper cells. Four first-degree relatives of these individuals were available for study. They had a normal proportion of OKT4+ lymphocytes but these cells had approximately half the normal number of OKT4 sites. This abnormality appears to be inherited as an autosomal recessive state.
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D000939:Epitopes / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011971:Receptors, Immunologic; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D011971:Receptors, Immunologic