[Induction of interferon production with dextran sulfate].
Interferon-inducing activity of polyanions (dextran Sulfate, native DNA, polyphosphate, polypentose, polyanetole sulfate, heparin) was studied. Dextran sulfate applied parenterally and enterally was found to be capable of inducing endogenous interferon production in white mice. The maximal titers of interferon (160 units/ml) were seen in the blood serum of mice upon administering the preparation in a dose of 20 mg/kg body mass. No substantial differences were discovered in the time course of interferon production whatever the route of administration.
D000818:Animals; D002477:Cells / Q000187:drug effects; D016264:Dextran Sulfate; D003911:Dextrans / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology; D007369:Interferon Inducers / Q000276:immunology*; D007372:Interferons / Q000097:blood; D051379:Mice; D014776:Virus Cultivation
D003911:Dextrans; D007369:Interferon Inducers; D007372:Interferons; D016264:Dextran Sulfate
Induktsiia vyrabotki interferona dekstransul'fatom.