Interaction of mouse interferon and platelet-derived growth factor during multiplication of BALB/c 3T3 cells.
Mouse fibroblast-drived interferon (MuIFN) at concentrations of 0.1-0.001 U/ml enhanced the multiplication of BALB/c 3T3 cells. Experiments with the cells cultured in 5% platelet poor plasma serum (PPPS) medium in which the cells not multiply without platelet derived growth factor (PDGF), suggested that there is a positive cooperativity between small amounts of MuIFN and submitogenic doses of PDGF. The growth-promoting activity of 10,000-1,000 U/ml detected in the partially purified MuIFN from C243 cells assayed in 5% PPPS medium was probably the result of the contamination of MuIFN preparations with a PDGF-like growth factor.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D006133:Growth Substances / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007372:Interferons / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000378:metabolism* / Q000502:physiology; D010982:Platelet-Derived Growth Factor
D006133:Growth Substances; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D007372:Interferons