title: Hearing loss induced by viscous fluids in the middle ear.
abstract: Dextran solutions of low viscosity (7.5 centipoise) and high viscosity (2.2 poise) were instilled in turn into the middle ears of guinea pigs, using an open bulla preparation. The degree of conductive hearing loss induced was assessed by measurement of the cochlear microphonic. Both solutions produced a comparable degree of hearing loss which was frequency dependent, ranging from 30 dB at 500 Hz to almost zero at 4000 Hz. The results indicate that the degree of conductive hearing loss produced by a serous effusion in otitis media is due solely to an effect on compliance in the middle ear and is independent of the viscosity of the effusion.
mesh_terms: D000818:Animals; D003187:Compliance; D003911:Dextrans; D004432:Ear, Middle / Q000503:physiopathology*; D005260:Female; D006168:Guinea Pigs; D034381:Hearing Loss / Q000209:etiology*; D006314:Hearing Loss, Conductive / Q000209:etiology* / Q000503:physiopathology; D010034:Otitis Media with Effusion / Q000150:complications; D014432:Tympanic Membrane / Q000503:physiopathology; D014783:Viscosity
chemical_list: D003911:Dextrans