Effect of (+)-cyanidanol-3 on receptor activity of lymphocytes and hepatocytes and on hepatocyte-lymphocyte conjugation in alcoholic liver disease.
The recirculation of lymphocytes and cell-mediated immunity show profound alterations in alcoholic liver disease. The use of cianidanol corrects a lot of these disturbances, in that: a) it can modify the receptor avidity of hepatocytes, b) it reduces the cell-mediated immune reactivity against liver specific protein antigen, diminishing the auto-immune reactions in alcoholic liver disease, c) it has no effect upon the conjugation process between the hepatocytes as target cells and cytotoxic effector cells, d) it decreases, however, the number of hepatocytes damaged after the conjugation process, and e) as a potent free-radical scavenger, it inhibits the cytotoxic effect of natural killer cells and monocytes, and in the same manner prevents the alteration of the hepatocyte membrane.
D000328:Adult; D001578:Benzopyrans / Q000627:therapeutic use*; D002392:Catechin / Q000627:therapeutic use*; D002448:Cell Adhesion / Q000187:drug effects; D000939:Epitopes; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000276:immunology; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D011971:Receptors, Immunologic / Q000187:drug effects
D001578:Benzopyrans; D000939:Epitopes; D011971:Receptors, Immunologic; D002392:Catechin