Indication of a possible role in a demyelinating neuropathy for an antigen shared between myelin and NK cells.
In three patients with monoclonal IgM antibodies to myelin-associated glycoprotein and a demyelinating neuropathy, the human monoclonal antibodies and HNK1, a mouse monoclonal antibody against human natural killer cells, reacted with the same region of myelin-associated glycoprotein. In these three patients there was a pronounced decrease in the number of circulating HNK1-positive cells. Taken together, these findings provide evidence that a cross-reactive cell surface antigen may be involved in an autoimmune response directed simultaneously against the nervous system and the immune system.
D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology*; D003429:Cross Reactions; D003711:Demyelinating Diseases / Q000209:etiology / Q000276:immunology*; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009185:Myelin Proteins / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000939:Epitopes; D007075:Immunoglobulin M; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein