[Role of prostaglandin, the kallikrein-kinin system and renal dopamine receptors in the mechanism of the natriuretic action of the beta-adrenoblocker obzidan].
It has been established in experiments on anesthetized rats that the beta-adrenoblocker obsidan inhibiting tubular sodium reabsorption in the kidneys provokes the natriuretic reaction which correlates with the increased blood flow in the cortex and in the external medullary substance. pO2 in these zones of the renal tissue remains unchanged. The inhibitor of prostaglandin biosynthesis indomethacin and the inhibitor of the kallikrein-kinin system contrykal did not affect the renal response to the drug under study. The dopamine blocker haloperidol prevented the hemodynamic shift in the cortical and in the external medullary layers and interfered with the inhibitory action of obsidan in tubular sodium transport. It is inferred that the natriuretic response to the action of beta-adrenoblockers is not linked with the increased prostaglandin biosynthesis in the kidneys or with activation of the kallikrein-kinin system but is partially governed by stimulation of dopamine receptors of the kidneys.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007610:Kallikreins / Q000502:physiology*; D007668:Kidney / Q000187:drug effects; D007705:Kinins / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*
D007705:Kinins; D011453:Prostaglandins; D011954:Receptors, Dopamine; D007611:Aprotinin; D011433:Propranolol; D007610:Kallikreins; D006220:Haloperidol; D007213:Indomethacin
Rol' prostaglandinov, kallikrein-kininovoĭ sistemy i dofaminovykh retseptorov pochek v mekhanizme natriĭureticheskogo deĭstviia beta-adrenoblokatora obzidana.