[Preoperative intravenous and intra-arterial cytostatic therapy (VMBP) in carcinoma of the head and neck].
Two groups of patients with carcinomas of the oropharynx and the oral cavity were selected for praeoperative cytostatic therapy. Vincristine, Methotrexate, Bleomycin and Cisplatin were administered intravenously and intra-arterially (VMBP). The remission rates of the tumours (complete and partial remission) were, for intra-arterial application, 81%, and for intravenous application, 66.7%, indicating a possible superiority of intra-arterial therapy. In 10 intra-arterial (47.6%) and in 8 intravenous cases (38.1%), a complete clinical remission was accomplished. This was confirmed by the histological examination of the tumours, where no tumour cells could be recognized.
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D008727:Methotrexate / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D001761:Bleomycin; D014750:Vincristine; D002945:Cisplatin; D008727:Methotrexate
Präoperative intravenöse und intraarterielle Zytostatikatherapie (VMBP) bei Karzinomen des Kopfes und Halses.