Ocular responses evoked by capsaicin and prostaglandin E2 are inhibited by a substance P antagonist.
Injection of capsaicin or prostaglandin E2 into the vitreous chamber of the rabbit eye resulted in miosis and breakdown of the blood-aqueous barrier, manifested in aqueous flare. Pretreatment with the neuronal blocker tetrodotoxin or the substance P antagonist (D-Pro, D-Trp)-SP greatly reduced the ocular responses to capsaicin and prostaglandin E2. The results suggest a role for neuronal substance P in the ocular response to injury.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology*; D015232:Dinoprostone; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D013373:Substance P / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D011458:Prostaglandins E; D013373:Substance P; D013779:Tetrodotoxin; C032132:substance P, prolyl(2)-tryptophan(7,9)-; D015232:Dinoprostone; D002211:Capsaicin