title: Non-radioisotopic estimate of body water and its spaces in hypertonic expansion.
abstract: Mathematically rigorous formulae of apparent sodium volume of distribution for body water and of stable sodium chloride space for extracellular volume were derived and applied to data from five anuric dogs infused with hypertonic saline. The error of the formula used in the past to compute apparent sodium volume of distribution was also computed and the errors introduced in the calculation of sodium chloride space by the experimental methods applied were corrected. Apparent sodium volume of distribution, computed from a correct formula, is a measure of body water and corrected estimates of sodium chloride space agree with radio-sulphate space estimates of extracellular volume.
mesh_terms: D000418:Albumins / Q000032:analysis; D000818:Animals; D001699:Biometry / Q000379:methods; D001834:Body Water / Q000032:analysis*; D002712:Chlorides / Q000032:analysis; D004285:Dogs; D005110:Extracellular Space / Q000032:analysis*; D005260:Female; D008433:Mathematics; D012462:Saline Solution, Hypertonic / Q000378:metabolism*; D012964:Sodium / Q000032:analysis; D012965:Sodium Chloride / Q000378:metabolism*; D013462:Sulfur Radioisotopes / Q000032:analysis
chemical_list: D000418:Albumins; D002712:Chlorides; D012462:Saline Solution, Hypertonic; D013462:Sulfur Radioisotopes; D012965:Sodium Chloride; D012964:Sodium