Rapid and precise down regulation of fast axonal transport of transmitter in an identified neuron.
Within 1 day after the removal of one branch of the bifurcated axon of an identified neuron in Aplysia, the cell body reduced its output of transmitter storage vesicles to adjust precisely for the decreased need. This adjustment terminated the initial consequence of the removal, the transport of an inappropriately large number of vesicles to the remaining synapses. The most likely cause of the reduction of transport of transmitter is the loss of information normally provided by the disconnected axon or synapses.
D000818:Animals; D001048:Aplysia / Q000502:physiology; D001370:Axonal Transport; D001369:Axons / Q000502:physiology*; D001692:Biological Transport; D003594:Cytoplasmic Granules / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin