title: [Whipple's disease with encephalopathy. A case report with review of the literature].
abstract: A 58 year-old man developed a progressive encephalopathy four years after Whipple's disease onset with digestive, lymph node, and multiple joint lesions, treated over a period of two years. The diagnosis of neurological manifestations of Whipple's disease was based on clinical findings and the presence of PAS+ inclusion bodies in CSF cells. The outcome was fatal in spite of antibiotic therapy. Diagnostic features of this rare neurological affection are discussed. Preventive treatment and surveillance of patients with Whipple's disease are necessary even after well-conducted therapy.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001928:Brain Diseases, Metabolic / Q000175:diagnosis*; D003704:Dementia / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008061:Whipple Disease / Q000175:diagnosis*
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Maladie de Whipple avec encéphalopathie. Un cas avec revue de la littérature.