title: A circulating sodium transport inhibitor and essential hypertension.
abstract: Evidence for the hypothesis that the rise in peripheral resistance that occurs in inherited hypertension is due largely to the observed rise in the circulating level of a sodium transport inhibitor is reviewed. A sequence of events is proposed linking a postulated genetic defect in the kidney's ability to excrete sodium, salt intake, and the rise in the circulating concentration of a sodium transport inhibitor and thereby the rise in peripheral resistance in essential hypertension.
mesh_terms: D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009399:Nephrons / Q000378:metabolism; D010455:Peptides; D012964:Sodium / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000097:blood / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
chemical_list: D010455:Peptides; C029311:serum sodium transport inhibitor; D012964:Sodium; D005954:Glucosephosphate Dehydrogenase; D000254:Sodium-Potassium-Exchanging ATPase