[Inosiplex-dependent interferon production in vivo and in vitro].
Inosiplex, an immunopotentiator, was shown to be capable of inducing interferon synthesis in vivo and in cell culture. Its concentrations of the order of 25 mg/mouse were to be most effective. The time course of production showed a late peak at 72 hours. The resulting interferon was not neutralized by antiserum to alpha- and beta-interferons. L929 cells of peritoneal exudate and splenocytes could synthesize interferon after treatment with inosiplex. The use of mixed cultures of these cells increased the effectiveness of interferon induction.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000494:pharmacology*; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis* / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D007369:Interferon Inducers; D007288:Inosine; D007372:Interferons; D007542:Inosine Pranobex
Inoziplekszavisimaia produktsiia interferona in vivo i in vitro.