Thiamine phosphorylated derivatives and bioelectrogenesis.
Kinetic as well as thermodynamic considerations favour the idea that the change in sodium conductance explaining the action potential, must result from a bimolecular reaction system. The fact that thiamine phosphorylated derivatives are associated with the specific protein forming the sodium channel could well mean that these thiamine derivatives and more specifically thiamine triphosphate are directly involved in the conductance change.
D000818:Animals; D004553:Electric Conductivity; D004594:Electrophysiology; D004734:Energy Metabolism; D007473:Ion Channels / Q000378:metabolism; D008566:Membranes / Q000502:physiology; D008956:Models, Chemical; D008968:Molecular Conformation; D010710:Phosphates / Q000378:metabolism; D012964:Sodium / Q000502:physiology; D013831:Thiamine / Q000031:analogs & derivatives* / Q000502:physiology; D013838:Thiamine Triphosphate / Q000494:pharmacology
D007473:Ion Channels; D010710:Phosphates; D013838:Thiamine Triphosphate; D012964:Sodium; D013831:Thiamine