Peculiarities of erythropoiesis in patients with chronic renal failure.
In 600 patients suffering from chronic renal insufficiency the cellularity of bone marrow, erythroid cells proliferative activity, erythroid cells destruction and iron incorporation rate, data of ferrokinetics, intracellular iron distribution, porphyrin synthesis rate were examined. On the basis of the obtained data the suggestion is put forward that metabolic disturbances are important in anemia development in uremic patients. One of the aspects of this problem is the role of disorders in the protein turnover causing changes in the synthesis of globin and porphyrin which are the primary components for heme synthesis. Special importance is attached to the changes in iron turnover, i.e. to its redistribution between stromal and heme pools.
D000740:Anemia / Q000209:etiology*; D001854:Bone Marrow Cells; D003404:Creatinine / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis; D006801:Humans; D007501:Iron / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000378:metabolism; D011166:Porphyrins / Q000096:biosynthesis
D011166:Porphyrins; D003404:Creatinine; D007501:Iron