[Changes in the hemoglobin fractions of nephroblastoma patients].
Hemoglobin fractions were studied in 80 patients suffering from nephroblastoma (Wilms' tumor). 10 out of 80 children had an elevated fetal hemoglobin value, higher than 2.5%, but as there was no other evidence for a thalassemia, we could not refer these patients to delta beta-thalassemia heterozygotes. An electrophoretic study of hemolyzates showed that 4 children had a uniform "quickly-proceeding" anomalous hemoglobin fraction localized in front of HbA2 which decreased in time. In one case, this anomaly was discovered in propositus and also in his father and paternal grandmother. A child suffering from unilateral sporadic Wilms' tumor and his mother had a Negro type hereditary persistence of fetal hemoglobin (HPHF). This complex of Wilms' tumor and HPHF is described for the first time. HPHF and nephroblastoma complex as a possible variant of intersticial deletion of the short arm of chromosome 11 is discussed. The diagnostic value of the study of hemoglobin fractions and the activity of enzymes (catalase, LDH-A), whose genes are localized on the short arm of chromosome 11, are also discussed. It would be useful for genetic counselling to select a group of children with high risk for nephroblastoma.
D002648:Child; D002872:Chromosome Deletion; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure; D004588:Electrophoresis, Cellulose Acetate; D005319:Fetal Hemoglobin / Q000032:analysis / Q000235:genetics; D006454:Hemoglobins / Q000032:analysis / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000097:blood / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D009396:Wilms Tumor / Q000097:blood / Q000235:genetics*
D006454:Hemoglobins; D005319:Fetal Hemoglobin
Izmeneniia gemoglobinovykh fraktsiĭ u bol'nykh s nefroblastomoĭ.