On the role of the C1-esterase inhibitor in cold urticaria.
Plasma samples from 20 patients with acquired cold urticaria were studied. The C1-esterase inhibitor activity was found to be low, but the total C1-esterase inhibitor concentration was normal. Prekallikrein, plasmin-alpha 2-antiplasmin complex, and kallikrein-like activity were also found to be within normal limits. Cold-promoted activation of coagulation factor VII occurred in 45% of the patient plasmas and resulted in a considerable drop in C1-esterase inhibitor activity.
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000032:analysis; D002648:Child; D003080:Cold Temperature; D003174:Complement C1 Inactivator Proteins / Q000097:blood* / Q000276:immunology; D005167:Factor VII / Q000032:analysis; D006801:Humans; D007610:Kallikreins / Q000097:blood; D008875:Middle Aged; D011288:Prekallikrein / Q000032:analysis; D014581:Urticaria / Q000097:blood* / Q000276:immunology
D000941:Antigens; D003174:Complement C1 Inactivator Proteins; D005167:Factor VII; D011288:Prekallikrein; D007610:Kallikreins