Agents that increase cellular cAMP inhibit production of interleukin-2, but not its activity.
Proliferation of lectin-treated mouse thymocytes induced by the tumor promoter, 12-0-tetradecanoyl-13-acetate, is markedly inhibited by cAMP analogues, prostaglandin E and methylisobutylxanthine. Proliferation induced by interleukin-2 is resistant to inhibition by these compounds. The tumor promoter induces interleukin-2 production in a subpopulation of lectin-treated thymocytes, and production of this lymphokine is inhibited by agents that increase cellular cAMP.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology*; D000527:Alprostadil; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007376:Interleukin-2 / Q000096:biosynthesis / Q000502:physiology*; D007700:Kinetics; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010704:Phorbols / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D013806:Theophylline / Q000031:analogs & derivatives*; D013950:Thymus Gland / Q000276:immunology
D007376:Interleukin-2; D010704:Phorbols; D011458:Prostaglandins E; D013806:Theophylline; D000242:Cyclic AMP; D000527:Alprostadil; D013755:Tetradecanoylphorbol Acetate; D015056:1-Methyl-3-isobutylxanthine