Heterogeneity in electrophoretic mobility of C3-derived molecules expressing D but not C-epitopes following in vivo activation of the complement system.
Four different populations of C3-derived molecules expressing D but not C epitopes were identified following in vivo activation of the complement system. The four molecular forms, differing in electrophoretic migration velocity, were assigned the nos. 1, 2, 3 and 4 after decreasing electrophoretic mobility. Analysis of the time-dependent changes in the relative concentration of the different molecular forms demonstrated an increase in the plasma concentration of population 4 and a decrease of populations 2 and 3, whereas form 1 remained rather constant after acute activation of the complement system.
D000818:Animals; D015478:Antigens, Heterophile / Q000032:analysis*; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis*; D015932:Complement C3c; D015933:Complement C3d; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D011817:Rabbits
D015478:Antigens, Heterophile; D003176:Complement C3; D000939:Epitopes; D015932:Complement C3c; D015933:Complement C3d