title: A species comparison of the histamine H2-receptor on mast cells and basophils.
abstract: The histamine H2-agonist dimaprit was employed in experiments to investigate the role of H2-receptors in mediator release systems from the rat, guinea-pig and man. Whereas inhibition of histamine release by dimaprit was observed in all 3 species, this effect appeared not always to be related to H2-receptor occupancy. Although the data in general support previous evidence for the presence of H2-receptors on human basophils and guinea-pig mast cells, the use of dimaprit as a pure H2-agonist in these studies is questioned. No evidence for H2-receptors on rat mast cells was obtained.
mesh_terms: D000818:Animals; D001491:Basophils / Q000378:metabolism*; D002927:Cimetidine / Q000031:analogs & derivatives*; D005260:Female; D005663:Furans / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D006168:Guinea Pigs; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D011899:Ranitidine; D051381:Rats; D011968:Receptors, Histamine / Q000378:metabolism*; D011970:Receptors, Histamine H2 / Q000378:metabolism*; D013045:Species Specificity; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D005663:Furans; D006146:Guanidines; D006635:Histamine H2 Antagonists; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D013844:Thiazoles; D002927:Cimetidine; D011899:Ranitidine; C023990:tiotidine