Keratinocytes form multi-cell clusters in the absence of cell division or collagen synthesis; tunicamycin interferes with cell cluster formation.
Cultivated human keratinocytes attach to substrate, spread, move, and collide forming multicell clusters in the absence of cell division and collagen synthesis. Tunicamycin profoundly retards the formation of keratinocyte clusters.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D004247:DNA / Q000096:biosynthesis; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism; D004847:Epithelial Cells; D005347:Fibroblasts / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives*; D006801:Humans; D007633:Keratins / Q000096:biosynthesis; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014415:Tunicamycin / Q000494:pharmacology*
D008937:Mitomycins; D014415:Tunicamycin; D016685:Mitomycin; D007633:Keratins; D003094:Collagen; D004247:DNA; D005944:Glucosamine; D013936:Thymidine