Monoclonal antibody reactive with the human epidermal-growth-factor receptor recognizes the blood-group-A antigen.
The hybridoma antibody TL5, which precipitates the EGF receptor from the human epidermoid carcinoma cell line A431, has been shown to recognize the blood-group-A carbohydrate structure. This conclusion has been reached from studies of (a) the binding of the antibody to glycoproteins and haemagglutination of erythrocytes with known blood-group-antigen activities and (b) the inhibition of binding of the antibody to a radiolabelled blood-group-A-active glycoprotein by structurally defined oligosaccharides.
D000017:ABO Blood-Group System / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D066246:ErbB Receptors; D006023:Glycoproteins / Q000276:immunology; D006386:Hemagglutination Tests; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D051379:Mice; D009844:Oligosaccharides / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000276:immunology*; D013329:Structure-Activity Relationship
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D000939:Epitopes; D006023:Glycoproteins; D009844:Oligosaccharides; D011956:Receptors, Cell Surface; D066246:ErbB Receptors