title: [Treatment of immune thrombopenic purpura in adults. Current concepts].
abstract: In immune thrombopenic purpura (ITP) therapy is aimed at achieving a safe blood platelet level, i.e. 50000/mm3. Platelet transfusions are helpful only in the case of serious bleeding. Corticosteroids are usually given first, but long-term efficiency can be expected in only one-third of patients. Splenectomy remains the best treatment, providing long-term remission in 50 to 85% of cases. Immunosuppressant therapy is used in intractable ITP; vinca alcaloids are the most effective agents. The value of plasma exchange, especially in cases of uncontrolled bleeding, and of high-dose intravenous gammaglobulin, is emphasized.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000628:therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D010956:Plasmapheresis; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy; D011696:Purpura, Thrombocytopenic / Q000276:immunology / Q000628:therapy*; D013156:Splenectomy; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D005719:gamma-Globulins
vernacular_title: Le traitement du purpura thrombopénique immunitaire de l'adulte. Conceptions actuelles.