Histamine release into tracheal lumen and bronchial reactivity. The histamine liberation of proteolytic enzymes in the tracheal lumen in relation to the bronchomotoric reactivity.
The influence of tracheal lavage in a restricted area, with a proteolytic enzyme (Pronase) on the bronchial response to challenge with ACH and AE was studied in 15 dogs. Histamine concentrations measured in the tracheal liquid after lavage with Pronase were smaller than the values after tracheal lavage with allergen. Airway response to ACH inhalation was significantly increased after tracheal lavage with Pronase. Effects of proteolytic enzymes and allergens on the tracheal wall are compared. Allergens and proteolytic enzymes evidence a different mode of action in increasing reactivity of peripheral airways.
D000485:Allergens / Q000494:pharmacology; D000818:Animals; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000209:etiology*; D004285:Dogs; D006636:Histamine Release; D011402:Pronase / Q000494:pharmacology*; D014132:Trachea / Q000502:physiology*
D000485:Allergens; D011402:Pronase