title: Liver hypertrophy in winter flounder following exposure to experimentally oiled sediments.
abstract: 1. Male winter flounder were exposed to sediments contaminated with Venezuelan crude oil in 3 laboratory experiments of 4-5 months duration. 2. Oil exposure resulted in significant increases in liver weight. This was particularly evident in fish weighing less than 400 g. 3. The enlarged livers of the oil-exposed flounder had reduced concentrations of DNA, protein, Na+ and Zn2+, and increased concentrations of lipid and phospholipid. 4. The reduced DNA and Na+ concentrations suggested liver hypertrophy rather than hyperplasia. 5. The increased phospholipid concentrations suggested growth of membrane structures such as endoplasmic reticulum.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004573:Electrolytes / Q000378:metabolism; D005399:Fishes / Q000502:physiology*; D005618:Fresh Water; D006529:Hepatomegaly / Q000139:chemically induced*; D008670:Metals / Q000378:metabolism; D010578:Petroleum / Q000633:toxicity*; D012313:RNA / Q000096:biosynthesis; D012621:Seasons; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D004573:Electrolytes; D008670:Metals; D010578:Petroleum; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D012313:RNA; D004247:DNA