Pharmacological properties of new cyclic derivatives of phenylsuccinimide and their influence on noradrenaline, dopamine, serotonin, 5-hydroxyindoleacetic acid, gamma-aminobutyric acid concentrations and monoaminooxidase activity in animal brains.
Three new cyclic derivatives of phenylsuccinimide (I-10, I-11 and IL-7) were subjected to preliminary pharmacological studies in animals. Minimal peripheral action and inhibitory influence on the CNS were noted (only IL-7) was found to stimulate CNS). Neurotoxic effects were similar to those of the classical succinimides . Anticonvulsant activity and behavioral effects of tested compounds are discussed in the light of their influence on neurotransmitters.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D002697:Chloral Hydrate / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D005106:Exploratory Behavior / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000187:drug effects; D013388:Succinimides / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000927:Anticonvulsants; D001679:Biogenic Amines; D013388:Succinimides; D012701:Serotonin; D002697:Chloral Hydrate; D006897:Hydroxyindoleacetic Acid; D005680:gamma-Aminobutyric Acid; D006591:Hexobarbital; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine