Clinical and microbiological evaluation of piperacillin in elective biliary surgery.
Fifty patients undergoing electric biliary surgery were given piperacillin 2 g i.m. 2 h preoperatively followed by 2 g i.v. at the beginning of the operation. Venous blood and bile from the gall bladder and common bile duct were assayed for piperacillin. Blood levels exceeded 100 mg 1(-1) in all instances unless the protocol was not followed. Both gallbladder and common bile duct bile levels exceeded 50 mg 1(-1), and the only exceptions were due to poor penetration into three obstructed gallbladders. Common bile duct levels exceeded 50 mg 1(-1) even in the presence of obstructive jaundice. Only one patient developed a minor postoperative wound infection.
D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000517:prevention & control*; D001646:Bile / Q000378:metabolism; D001660:Biliary Tract Diseases / Q000382:microbiology / Q000601:surgery*; D001682:Biological Availability; D003135:Common Bile Duct; D005704:Gallbladder; D006801:Humans; D007430:Intraoperative Care; D010878:Piperacillin / Q000378:metabolism / Q000627:therapeutic use*; D011300:Preoperative Care; D013530:Surgical Wound Infection / Q000517:prevention & control*
D010878:Piperacillin