A new polymorphic determinant distinct from but expressed concomitantly with an HLA-Bw44 specificity.
A new antigenic determinant defined by a monoclonal antibody (6.7) is described which displays restricted expression being present only on the cells of the immunizing donor and his father and not on a panel of over one hundred unrelated HLA-typed cells. The determinant segregated with the HLA haplotypes of the immunizing donor's family and was shown by immunochemical and capping studies to be located on a subpopulation of HLA molecules. Further capping and antibody-blocking studies using HLA-typing alloantisera revealed that the 6.7-reactive determinant was located on the same molecules that expressed the HLA-Bw44 specificity but was a separate epitope to the polymorphic HLA specificity.
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D000939:Epitopes / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens; D059948:HLA-B44 Antigen; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011110:Polymorphism, Genetic; D012016:Reference Values
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000939:Epitopes; D006680:HLA Antigens; D015235:HLA-B Antigens; D059948:HLA-B44 Antigen