[Esophageal ulcer caused by mexiletine].
The anti-arrhythmic drug mexiletine caused an oesophageal ulcer, confirmed by endoscopy and biopsy, in a 72-year-old woman. This side-effect has not previously been published. The clinical course was similar to that observed after oesophageal ulceration caused by other drugs. An ulcer in the piriform recess also developed in a 63-year-old man who was taking both acetylsalicylic acid and mexiletine: it cleared up after mexiletine had been discontinued.
D000368:Aged; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D004935:Esophageal Diseases / Q000139:chemically induced*; D005260:Female; D006469:Hemoptysis / Q000139:chemically induced; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D011405:Propafenone; D011427:Propiophenones / Q000627:therapeutic use; D011437:Propylamines / Q000009:adverse effects*; D014456:Ulcer / Q000139:chemically induced
D011427:Propiophenones; D011437:Propylamines; D008801:Mexiletine; D011405:Propafenone
Osophagus-Ulcus durch Mexiletin.