[Blockade of the anti-influenza specific proliferative response of cloned cell lines restricted either by HLA-DR7 or HLA-DR1 molecules or by a still-unknown molecule].
Four different continuous cell lines of T lymphocytes are described, three of them were obtained by cloning. Their activity is restricted in three cases by a histocompatibility antigen undistinguishable from HLA-DR. The last one is restricted by an autologous unidentified structure. The first three lines are specific for a viral antigen corresponding to a subtype of the H3 hemagglutinin. The fourth line seems to react with an hitherto undescribed antigen shared by type A and type B influenza viruses.
D000911:Antibodies, Monoclonal / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II
Blocage de la réponse proliférative spécifique de lignées clonées anti-influenza restreinte soit par les molécules HLA-DR7 ou HLA-DR1 soit par une molécule encore inconnue.