title: Effects of pectin on glycaemia and insulinaemia after starch loading in normal, alloxan diabetic, and pancreatic duct-occluded rats.
abstract: In normal rats, and in rats with reduced intraluminal amylolytic activity, acute administration of low methoxyl pectin with soluble starch via an oro-gastric tube was found to delay starch digestion. In normal rats pectin slightly lowered plasma glucose levels after a starch load. In pancreatic duct-occluded rats, in which intestinal pancreatic digestive enzyme activities are markedly reduced, an increased insulin secretion and a reduced glucose response were seen after starch loading even without the addition of pectin, when compared to normal control rats. In these duct-occluded rats pectin was found to further reduce starch digestion, and markedly suppress plasma glucose levels after a starch load without changing plasma insulin levels. In moderately alloxan diabetic rats, in which intestinal amylase activity also was substantially reduced, pectin reduced the glucose response to starch to a similar extent (about 30%) as in duct-occluded rats without changing the impaired insulin response. The results suggest that pancreatic insufficiency accompanied by reduced intraluminal activities of pancreatic digestive enzyme activities may be associated with a decreased glucose and an increased insulin response to starch loading and that the ability of dietary fibre to reduce postprandial glycaemia may, inter alia, involve an inhibiting action by fibre on starch digestion, especially manifested in conditions of amylolytic insufficiency.
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004063:Digestion / Q000187:drug effects; D007328:Insulin / Q000097:blood*; D007422:Intestines / Q000201:enzymology; D008297:Male; D010179:Pancreas / Q000201:enzymology; D010183:Pancreatic Ducts / Q000502:physiology*; D010368:Pectins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013213:Starch / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010368:Pectins; D013213:Starch; D000681:Amylases