title: Importance of the keratinized epithelial cell in bacterial adherence.
abstract: The effect of cellular pathology and keratinization of skin and nasal cells upon binding of Staphylococcus aureus were examined. Adherence with epithelial cells obtained from either the skin or nasal mucosa of patients with atopic dermatitis was greater than that observed with normal cells (p less than 0.001); the difference in adherence between psoriatic and normal cells was not statistically significant. Tested nasal cells were microscopically differentiated into 4 general types based on stage or layer of keratinization: spinous, low granular, high granular, and keratin. The degree of adherence was related to the progress of keratinization. Data indicated the existence of 2 types of receptors for S. aureus on nasal cells: One, present upon both granular and fully keratinized cells, is not blocked by teichoic acid and appears responsible for the higher bacterial counts on atopic cells; the second is found on keratinized cells only and is susceptible to teichoic acid.
mesh_terms: D000268:Adhesiveness; D018407:Bacterial Physiological Phenomena; D003876:Dermatitis, Atopic / Q000503:physiopathology; D004848:Epithelium / Q000502:physiology; D006801:Humans; D007633:Keratins / Q000502:physiology*; D009297:Nasal Mucosa / Q000382:microbiology / Q000502:physiology; D011565:Psoriasis / Q000503:physiopathology; D012867:Skin / Q000382:microbiology; D012879:Skin Physiological Phenomena; D013211:Staphylococcus aureus / Q000502:physiology
chemical_list: D007633:Keratins