Coronary vascular responsiveness to non-eicosanoid vasoconstrictors in the perfused diabetic rat heart.
We tested arginine vasopressin, and a dihydropyridine calcium agonist, BAY K-8644 in isolated perfused hearts from control and diabetic rats. Arginine vasopressin (1-100 ng/ml) and BAY K-8644 (100-500 ng/ml) significantly increased coronary perfusion pressure during constant flow perfusion indicative of coronary vasoconstriction. However, no significant potentiation was observed between diabetic rats and their weight matched controls for either vasoconstrictor.
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D014662:Vasoconstrictor Agents; D001127:Arginine Vasopressin; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D009543:Nifedipine