Quantitative effect of H-2-linked gene(s) on antibody response to human gamma-globulin.
H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F2 interline hybrids, the gene(s) linked to the H-2 phenotype of H mice has a "low" effect, and the gene(s) linked to the H-2 phenotype of L mice a "high" effect on the magnitude of antibody response to HGG. In H and L mice, the non-specific polygenic control of antibody responsiveness is able to compensate/counteract the inverse effect of HGG-specific H-2-linked gene(s) since the usual interline difference is observed.
D000818:Animals; D000917:Antibody Formation; D003433:Crosses, Genetic; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D005719:gamma-Globulins / Q000276:immunology*
D006183:H-2 Antigens; D005719:gamma-Globulins