The influence of inhibitors of RNA and protein synthesis on dexamethasone action in carrageenin paw edema and adjuvant arthritis of rats.
The anti-inflammatory effect of dexamethasone in carrageenin paw edema and in adjuvant arthritis of rats was not influenced by simultaneous injection of RNA/protein synthesis inhibitors. The increase of the plasma alpha 2-microglobulin level during adjuvant arthritis was significantly reduced after administration of RNA/protein synthesis inhibitors. This inhibitory effect was abolished by simultaneous dexamethasone treatment. The present results do hardly support the hypothesis that the anti-inflammatory activity of dexamethasone and other glucocorticosteroids in carrageenin edema and adjuvant arthritis of rats might be mediated by de novo protein synthesis.
D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D002351:Carrageenan; D003513:Cycloheximide / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D005528:Foot; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D003609:Dactinomycin; D012313:RNA; D003907:Dexamethasone; D002351:Carrageenan; D003513:Cycloheximide