[Substance P as a factor in resistance to emotional stress].
The effect of substance P--an endogenous brain peptide--on the resistance to chronic emotional stress was studied in rats. A single administration of the peptide (125 or 250 mkg/kg) elicits a highly significant increase of rats resistance to chronic emotional stress and reduces the raise of adrenals weight, hemodynamic fluctuations and emotional reactivity.
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration; D012149:Restraint, Physical / Q000009:adverse effects; D013315:Stress, Psychological / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D013373:Substance P / Q000627:therapeutic use*
D013373:Substance P
Substantsiia P kak faktor ustoĭchivosti k emotsional'nomu stressu.