title: Cytostatic and reverse-transforming therapies of cancer - a brief review and future prospects.
abstract: Cytostatic cancer therapies are defined as those which retard cancer growth by intervening selectively in the disordered control mechanisms responsible for malignant behavior, without producing direct cytotoxicity. A number of possible approaches to cytostatic therapy are now under investigation and are briefly reviewed here - cyclic AMP congeners and promoters, prostaglandin precursors, thioproline, benzaldehyde, retinoids, interferon, chalones, antineoplastons, protease inhibitors, polar solvents. Suggestions for the further development of cytostatic therapies are offered, and a role for cytostatic therapy within a broad global concept of cancer therapy is proposed.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001547:Benzaldehydes / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D000242:Cyclic AMP / Q000502:physiology; D006131:Growth Inhibitors / Q000627:therapeutic use; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D011480:Protease Inhibitors / Q000627:therapeutic use; D012997:Solvents / Q000627:therapeutic use; D013844:Thiazoles / Q000627:therapeutic use; D053778:Thiazolidines; D014801:Vitamin A / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001547:Benzaldehydes; D006131:Growth Inhibitors; D011480:Protease Inhibitors; D012997:Solvents; D013844:Thiazoles; D053778:Thiazolidines; D014801:Vitamin A; D007372:Interferons; D000242:Cyclic AMP; C003438:thiazolidine-4-carboxylic acid