Chronic antidepressant treatment and central 5-HT synapses.
The present studies have shown that chronic antidepressant treatment with desipramine, imipramine, zimelidine and alaproclate led to adaptive changes in both pre- and postsynaptic 5-hydroxytryptamine (5-HT) receptor mechanisms which appear to result in 5-HT sub- or supersensitivity development depending upon the 5-HT nerve terminal systems analyzed. The results underline the heterogeneity of the central 5-HT neurone systems in their responses to chronic antidepressant treatment. An involvement of 5-HT comodulators is postulated in the actions of antidepressants on central 5-HT synapses. Finally, the results point to the importance of 5-HT neurone systems as targets for the action for antidepressant drugs and they may mediate at least some of the therapeutic activity of antidepressant drugs.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002352:Carrier Proteins; D003345:Corticosterone / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007099:Imipramine / Q000378:metabolism; D008238:Lysergic Acid Diethylamide / Q000378:metabolism; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000032:analysis; D011985:Receptors, Serotonin / Q000032:analysis / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology
D000928:Antidepressive Agents; D002352:Carrier Proteins; D010908:Pituitary Hormones, Anterior; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; C027775:imipramine receptor; D012701:Serotonin; D013373:Substance P; D013134:Spiperone; D004082:Dihydroalprenolol; D008238:Lysergic Acid Diethylamide; D000242:Cyclic AMP; D007099:Imipramine; D003345:Corticosterone