[Immunoelectrophoresis analysis of the antigenic composition of E. coli K12 hybrids which acquired the serological specificity of S. newcastle and S. flexneri].
Genetic and immunoelectrophoretic studies confirm earlier data on the presence of 2 specific antigens of acidic nature in S. newcastle; one of them is a specific thermolabile K-antigen responsible for type IV specificity of these bacteria. The data concerning the differences in the genetic determinants controlling the synthesis of O- and K-antigens in S. newcastle have been obtained. S. newcastle O- and K-antigens did not react with S. flexneri in the group serum system 3, 4, which indicates that S. newcastle are serologically isolated and form a separate taxonomic group of dysentery bacteria. The existence of cross reactions between S. flexneri and S. newcastle due to the presence of neutral R-core antigens common to these 2 species has been shown . Immunoelectrophoresis in agar is the most promising and informative method in genetic and chemical studies of the antigenic structure of bacteria.
D000942:Antigens, Bacterial / Q000032:analysis*; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis; D004926:Escherichia coli / Q000235:genetics / Q000276:immunology*; D005144:F Factor; D005798:Genes, Bacterial; D007122:Immunoelectrophoresis; D012703:Serotyping; D012760:Shigella / Q000235:genetics / Q000276:immunology*; D012763:Shigella flexneri / Q000235:genetics / Q000276:immunology
D000942:Antigens, Bacterial; D000939:Epitopes
Immunoélektroforeticheskiĭ analiz antigennogo sostava gibridov E. coli K12, priobretshikh serologicheskuiu spetsifichnost' S. newcastle i s. flexneri.