Unusual 'spike-wave stupor' in a patient with manic-depressive psychosis treated with amitriptyline.
'Spike-wave stupor' was observed in a 58-year-old male patient with manic-depressive psychosis. Almost continuous atypical spike-wave activity was seen in conjunction with a stuporous episode with stereotyped automatism. Intravenous diazepam ended both the electroencephalographic epileptiform discharges and the clinical stupor. Before and during this episode the patient was treated with an average-dose amitriptyline monotherapy. There was no family history of epileptic seizures. The patient had had electroconvulsive therapy. The history suggests that the analeptic property of amitriptyline induced the 'spike-wave stupor' in this patient.
D000200:Action Potentials; D000639:Amitriptyline / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000503:physiopathology; D003128:Coma / Q000139:chemically induced* / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014474:Unconsciousness / Q000139:chemically induced* / Q000503:physiopathology
D000639:Amitriptyline