[Presence of 2 different epitopes on the human beta 2-microglobulin defined by monoclonal antibodies].
Two monoclonal antibodies recognizing monomorphic determinants on class I antigens of MHC were characterized. They were shown to recognize beta 2m by cytotoxicity inhibition studies. The epitopes recognized were different, as assayed by cross-inhibition and phylogenetical studies. One antibody recognized free as well as HLA-associated beta 2m. The other reacted with a conformational epitope which was well conserved during evolution.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001609:Beta-Globulins / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008251:Macaca / Q000276:immunology; D002679:Pan troglodytes / Q000276:immunology; D010215:Papio / Q000276:immunology; D010802:Phylogeny; D001613:beta 2-Microglobulin / Q000032:analysis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D001609:Beta-Globulins; D000939:Epitopes; D006680:HLA Antigens; D001613:beta 2-Microglobulin
Présence de deux épitopes différents sur la beta 2-microglobuline humaine définis par des anticorps monoclonaux.