Effects of dextran sulphate (DXS) on lymphocyte localization in complement-deficient mice: evidence that the fifth component of complement is not implicated in the DXS activity.
The effects of subcutaneously or intraperitoneally administered dextran sulphate (DXS) (50 mg/Kg) on the subsequent 1 h localization of intravenously injected radiolabelled lymph node cells was investigated in complement deficient mice which lack C5. DXS proved to be equally as potent in depressing cell localization in deficient as compared to normal mice. These findings indicate that the terminal complement components are not essential for DXS activity.
D000818:Animals; D002450:Cell Communication / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D003167:Complement Activation / Q000187:drug effects; D003182:Complement C5 / Q000172:deficiency*; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology*; D005260:Female; D008198:Lymph Nodes / Q000166:cytology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D051379:Mice
D003182:Complement C5; D003911:Dextrans; D016264:Dextran Sulfate