title: Induction by chemically modified actin derivatives of antibody specificity. A relation between modified sites and antibody interactions with monomeric and filamentous actins.
abstract: A comparison of specific antibodies induced by unfolded actins modified either by oxidation or by arylation of lysine residues was reported. We have focused our work on binding properties with filamentous actin and located its preferential antigenic sites for the anti-arylated-actin antibodies in the C-part of the molecule. An interference of anti-oxidized actin antibodies upon actin polymerisation has also been reported.
mesh_terms: D000199:Actins / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D000939:Epitopes; D005779:Immunodiffusion; D007700:Kinetics; D046911:Macromolecular Substances; D010084:Oxidation-Reduction; D011487:Protein Conformation; D011817:Rabbits; D011863:Radioimmunoassay; D013329:Structure-Activity Relationship
chemical_list: D000199:Actins; D000906:Antibodies; D000936:Antigen-Antibody Complex; D000939:Epitopes; D046911:Macromolecular Substances