A new serially transplantable human prostatic cancer (HONDA) in nude mice.
A new serially transplantable human prostatic cancer (HONDA) in nude mice was established from a patient with metastatic prostate carcinoma. The tumor grows well in male nude mice. Doubling time of the tumor weight at passage #13 was 9.5 +/- 0.87 days (mean +/- SD). The tumor retains the original histological features of adenocarcinoma even after 6 years of continuous passage. High levels of human prostatic acid phosphatase were detected by radioimmunoassay in sera from the tumor-bearing mice. The tumor cells contain human prostate specific antigen. Electron microscopy showed particles resembling type A retroviruses in cisterns of endoplasmic reticulum, and particles resembling type C retroviruses in the intercellular space of the tumor cells. The tumor grew well in female mice treated with testosterone, but not in untreated female mice or castrated male mice.
D000230:Adenocarcinoma / Q000276:immunology / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D002369:Castration; D002460:Cell Line; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000276:immunology / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology; D012190:Retroviridae
D000951:Antigens, Neoplasm; D017430:Prostate-Specific Antigen