Pathogenic factors in bone resorption in cholesteatoma.
Factors present in skin appear to enhance bone resorption in chronic otitis media. These skin factors were replicated in a series of experiments using an animal model. The presence of activated granulation tissue is a universal finding in bone resorption in otitis media. Skin promotes bone resorbing connective tissue by the action of keratin as a foreign body, by the enhancement of middle ear sepsis, by stimulation and activation of inflammatory cells and most importantly through the creation of pressure.
D000818:Animals; D001424:Bacterial Infections / Q000503:physiopathology; D001862:Bone Resorption; D002781:Cholesteatoma / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D002908:Chronic Disease; D015232:Dinoprostone; D004195:Disease Models, Animal; D007633:Keratins / Q000502:physiology; D008222:Lymphokines / Q000502:physiology; D003012:Microbial Collagenase / Q000502:physiology; D010033:Otitis Media / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D011312:Pressure; D011458:Prostaglandins E / Q000502:physiology; D051381:Rats
D008222:Lymphokines; D011458:Prostaglandins E; C008718:osteoclast activating factor; D007633:Keratins; D003012:Microbial Collagenase; D015232:Dinoprostone