5-hydroxytryptophol in human cerebrospinal fluid: conjugation, concentration gradient, relationship to 5-hydroxyindoleacetic acid, and influence of hereditary factors.
The serotonin metabolite 5-hydroxytryptophol was studied in human cerebrospinal fluid. A minor fraction (approximately 13%) was found in conjugated form from which it was liberated by treatment with sulphatase containing beta-glucuronidase activity. A concentration gradient of 5-hydroxytryptophol concentration was shown on lumbar tapping and the concentration in ventricular CSF was about 2.5 times higher than that in lumbar CSF. 5-Hydroxytryptophol and 5-hydroxyindoleacetic acid concentrations were significantly correlated in healthy, psychotic, and depressed subjects, but not in alcoholics. 5-Hydroxytryptophol concentrations in CSF of psychotic and depressed subjects were not different from those of healthy controls (4.22 pmol/ml +/- 0.15, SEM). In healthy subjects, hereditary factors seemed to have little influence on the CSF level of 5-hydroxytryptophol.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000437:Alcoholism / Q000134:cerebrospinal fluid; D003863:Depression / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D006917:Hydroxytryptophol / Q000134:cerebrospinal fluid*; D007211:Indoles / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid; D014430:Twins, Monozygotic
D007211:Indoles; D006917:Hydroxytryptophol; D006897:Hydroxyindoleacetic Acid