title: Site of the ganglion blocking action of gardneramine and hirsutine in the dog urinary bladder in situ preparation.
abstract: The ganglion blocking site of gardneramine (GA) and hirsutine (HS) was studied in the dog urinary bladder in an in situ preparation. GA and HS selectively inhibited the DMPP-induced contraction without having an antagonistic effect on the McN-A-343-induced and acetylcholine-induced contraction. In addition, since GA and HS showed a local anesthetic action weaker than that of procaine, the effect of procaine was studied on the same preparation. Procaine inhibited the McN-A-343-induced contraction, and it slightly inhibited the DMPP-induced and acetylcholine-induced contraction. From these findings, it is concluded that GA and HS inhibited the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor played a main role.
mesh_terms: D008455:(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride / Q000494:pharmacology; D000109:Acetylcholine / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D004285:Dogs; D005260:Female; D005730:Ganglionic Blockers / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D011343:Procaine / Q000494:pharmacology; D001743:Urinary Bladder / Q000502:physiology*
chemical_list: D000470:Alkaloids; D005730:Ganglionic Blockers; C038368:gardneramine; D011343:Procaine; D004246:Dimethylphenylpiperazinium Iodide; D008455:(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; D001285:Atropine; D000109:Acetylcholine; C038369:hirsutine