Epithelial cell proliferation of oral lichen planus in patients treated with an aromatic retinoid.
In 4 patients with lichen planus mucosae (l.p.m.) biopsies were taken from the involved and uninvolved buccal sides before treatment and from the affected side after a 3-week systemic therapy with aromatic retinoid (Ro 10-9359; 50 mg/die). After in vitro labelling with 3H-thymidine the epithelial cell proliferation was determined histo-autoradiographically. In atrophic lesions of l.p.m., increased 3H-thymidine labelling indices were observed during retinoid therapy. After 3 weeks of treatment the augmented relative portion of labelled basal cells (quotient LIbas/LIsuprabas) was found to be lowered, indicating a tendency of proliferating cells to regain normal distribution in the progenitor compartment of the mucosa epithelium.
D000328:Adult; D000336:Aerosols; D001345:Autoradiography; D001706:Biopsy; D002455:Cell Division / Q000187:drug effects; D002610:Cheek; D005050:Etretinate / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology*; D013936:Thymidine / Q000378:metabolism; D014212:Tretinoin / Q000031:analogs & derivatives*; D014316:Tritium
D000336:Aerosols; D014316:Tritium; D014212:Tretinoin; D005050:Etretinate; D013936:Thymidine