title: [Methods of directly influencing the metastatic process].
abstract: The pathways of action of some agents modifying tumor dissemination were studied experimentally. The preventive effect of interferon upon metastatic spreading was found to be due to activation of effector cells of non-specific immune surveillance. A relationship between tumor dissemination process and the condition of neuro-regulatory mechanisms of target-organ was established. For example, it was shown that an injury to the vascular wall of the target-organ caused by hypercatecholemia and steady rise in adrenocortical hormone levels is, to a degree, a factor of metastatic spread stimulation following primary tumor removal.
mesh_terms: D000818:Animals; D006131:Growth Inhibitors / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology; D007545:Isoproterenol / Q000627:therapeutic use; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology* / Q000517:prevention & control; D009374:Neoplasms, Experimental / Q000601:surgery; D011433:Propranolol / Q000627:therapeutic use; D013312:Stress, Physiological / Q000503:physiopathology; D013481:Superoxides / Q000096:biosynthesis; D013852:Thiotepa / Q000627:therapeutic use
chemical_list: D006131:Growth Inhibitors; D013481:Superoxides; D007372:Interferons; D013852:Thiotepa; D011433:Propranolol; D007545:Isoproterenol
vernacular_title: Nekotorye puti napravlennykh vozdeĭstviĭ na protsess metastazirovaniia.