[Interferon-inducing effect of influenza viruses following aerogenic and oral administration in NMRI mice].
The aim of our study was to investigate the interferoninducing effect of aerogenic or oral uptake of influenza viruses in animals. NMRI-mice were infected with mouse-adapted influenza viruses (A/PR/8/34, H1 N1) by aerogen and oral route. In one-day-intervals interferon titers were determined in lung lavage fluids and in lung tissues within nine days after infection. The aerogenic infection led to an increase in interferon followed by a plateau and followed by a slope. The same course of interferon given in lower values was seen in animals after oral virus uptake. The results support the idea of a stimulation of local defense mechanisms in the lung after oral antigen uptake.
D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D005260:Female; D007114:Immunization; D007372:Interferons / Q000032:analysis* / Q000276:immunology; D008168:Lung / Q000032:analysis*; D051379:Mice; D008815:Mice, Inbred Strains; D009975:Orthomyxoviridae / Q000276:immunology*
D000336:Aerosols; D007372:Interferons
Die interferoninduzierende Wirkung von Influenzaviren nach aerogener und oraler Applikation bei NMRI-Mäusen.