Antibiotics from Basidiomycetes. XVI. Antimicrobial and cytotoxic polyines from Mycena viridimarginata Karst.
Two new biologically active polyines were isolated from cultures of the fungus Mycena viridimarginata. Their structures were elucidated by spectroscopic and chemical methods as 10-hydroxy-undeca-2,4,6,8-tetraynamide (1) and 3,4,13-trihydroxy-tetradeca-5,7,9,11-tetraynoic acid-gamma-lactone (2). The main component (1) is highly antibiotically active and cytotoxic.
D000480:Alkynes / Q000096:biosynthesis / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D005658:Fungi / Q000187:drug effects; D053284:Polyunsaturated Alkamides; D053279:Polyynes; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
D000480:Alkynes; D000900:Anti-Bacterial Agents; D053284:Polyunsaturated Alkamides; D053279:Polyynes; D012313:RNA; C036018:10-hydroxy-undeca-2,4,6,8-tetraynamide; C036019:3,4,13-trihydroxy-tetradeca-5,7,9,11-tetraynoic acid-gamma-lactone; D004247:DNA