Clinical application of fibrin glue in cardiovascular surgery.
Since 1978, fibrin glue has been applied in 268 patients. The indications were: (1) sealing of woven Dacron, (2) sealing of knitted Dacron, (3) control of various bleeding sites. The "blood preclotting" and "fibrin sealing" methods were compared in 32 patients with an aortoventriculoplasty operation using Dacron patches. In the fibrin glue group there was a significant reduction in postoperative blood loss as well as a shortening of the operation time (period of protamin administration to skin closure). From the data it can be concluded that sealing woven Dacron prostheses with fibrin glue is superior to conventional blood preclotting.
D001011:Aorta / Q000601:surgery; D001807:Blood Vessel Prosthesis; D006348:Cardiac Surgical Procedures / Q000379:methods; D013504:Cardiovascular Surgical Procedures; D004338:Drug Combinations / Q000627:therapeutic use; D005176:Factor XIII / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D006489:Hemostatic Techniques; D006801:Humans; D013917:Thrombin / Q000627:therapeutic use*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin