[Effect of dextran 60,000(D 60) and hydroxyethyl starch 450,000 (HES 450) on lymphocyte transformation].
Lymphocytes of volunteers were recovered, isolated and H3 thymidine incorporation was measured in the presence of D 60 and HES 450 with and without PHA. Without mitogen dextran caused only a marginal increase of incorporation whereas HES brought about no change. When PHA-stimulation was used, both compounds seemed not to influence H3-thymidine incorporation. It is concluded that in vitro even in molar concentrations corresponding to clinical haemodilution these solutions appear not to suppress lymphocytic activity.
D000328:Adult; D003911:Dextrans; D006438:Hemodilution; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D008970:Molecular Weight; D010835:Phytohemagglutinins / Q000494:pharmacology; D013213:Starch / Q000031:analogs & derivatives*; D013936:Thymidine / Q000378:metabolism
D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D010835:Phytohemagglutinins; D013213:Starch; D013936:Thymidine
Der Einfluss von Dextran 60 000 (D 60) und Hydroxyäthylstärke 450 000 (HAS 450) auf die Lymphozytentransformation.