The genetics of vitiligo.
The genetics of vitiligo has been studied in 150 probands and their families. A familial concentration of the disease has been demonstrated which supports the concept that hereditary factors contribute to the etiology of vitiligo. Segregation analysis was not consistent with inheritance at a single autosomal or x-linked locus. Further analysis suggested that vitiligo is determined by multifactorial inheritance. An estimate of heritability of liability was found to be 72.4%, indicating that genetic factors play a significant role in the etiology.
D000328:Adult; D002648:Child; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005260:Female; D005799:Genes, Dominant; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D010375:Pedigree; D014820:Vitiligo / Q000235:genetics*