title: [Combined use of interferon inducers and recombinant influenza viruses for protection from the disease].
abstract: The data on the use of national interferon inducers ( polyguacyl and double-stranded RNA) in combination with original H1N1 and H3N2 influenza viruses and recombinant strains with the same antigenic properties in laboratory animals are presented. Recombinants were found to produce a more marked effect: 3--6-fold increased protection of mice depending on the interferon inducer, higher titres of interferon and antibody, than the original influenza viruses. A simultaneous use of interferon inducers and recombinant influenza virus strains may be recommended for influenza prevention.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004274:DNA, Recombinant; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007369:Interferon Inducers / Q000008:administration & dosage*; D007372:Interferons / Q000097:blood; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D000914:Antibodies, Viral; D004274:DNA, Recombinant; D007252:Influenza Vaccines; D007369:Interferon Inducers; D014613:Vaccines, Attenuated; D007372:Interferons
vernacular_title: Kombinirovannoe ispol'zovanie induktorov interferona s rekombinantnymi virusami grippa dlia zashchity ot zabolevaniia.