Electron immunocytochemical localization of enkephalin-like material in catecholamine-containing cells of the carotid body, the adrenal medulla, and in pheochromocytomas of man and other mammals.
Enkephalin-like immunoreactivity has been localized to electron-dense secretory granules of cat and piglet carotid bodies and adrenal medullae, horse adrenal medulla, and also to human adrenal medulla and pheochromocytomas using a gold-labeled antibody technique performed at the electron microscopic level. The same granules were also demonstrated to exhibit dopamine-beta-hydroxylase-like immunoreactivity, which suggests a granular colocalization of amines and peptides in catecholamine-storing cells.
D000310:Adrenal Gland Neoplasms / Q000648:ultrastructure*; D000313:Adrenal Medulla / Q000648:ultrastructure*; D000818:Animals; D002344:Carotid Body / Q000648:ultrastructure*; D002395:Catecholamines / Q000032:analysis*; D002415:Cats; D004299:Dopamine beta-Hydroxylase / Q000032:analysis; D004723:Endorphins / Q000032:analysis*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007106:Immune Sera; D008854:Microscopy, Electron; D010673:Pheochromocytoma / Q000648:ultrastructure*; D013194:Staining and Labeling
D002395:Catecholamines; D004723:Endorphins; D004745:Enkephalins; D007106:Immune Sera; D004744:Enkephalin, Methionine; D004299:Dopamine beta-Hydroxylase