Pharmacokinetics and biotransformation of the prostacyclin analogue, ZK 36 374, in the beagle dog.
Tritium-labelled ZK 36 374 was administered to three female beagle dogs intravenously and orally in a dose of 200 micrograms/kg. Blood and plasma levels and excretion with urine and feces of drug and metabolites were measured. ZK 36 374 was rapidly absorbed. The bioavailability was estimated as about 10% of the dose. The concentration of radio-labelled compounds in the plasma declined in three phases with half-lives of 3 min, 46 min and approx. 2 d. The half-life of the unchanged drug was 14 min. ZK 36 374 was totally metabolized and excreted mainly via the kidneys.
D001711:Biotransformation; D011464:Epoprostenol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D016285:Iloprost; D007700:Kinetics; D008657:Metabolic Clearance Rate
D011464:Epoprostenol; D016285:Iloprost