Delayed cerebral development in twins with congenital hyperthyroidism.
Twins had congenital hyperthyroidism and delayed cerebral development manifested as ventriculomegaly, increased space in the interhemispheric fissure, and an exaggerated gyral pattern on cranial computed tomographic scans. At 3 1/2 years of age, both children had delayed development. Fetal and neonatal hyperthyroidism may interfere with normal brain growth and maturation with both neuranatomic and developmental sequelae.
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000254:growth & development*; D002552:Cerebral Ventricles / Q000473:pathology; D014695:Cerebral Ventriculography; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology*; D004200:Diseases in Twins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000151:congenital*; D007223:Infant; D007231:Infant, Newborn; D013997:Time Factors; D014057:Tomography, X-Ray Computed