Modulation of production of hepatitis B surface antigen by a human hepatoma cell line.
Three drugs were assayed for their capacity to inhibit hepatitis B surface antigen (HBsAg) production by the PLC/PRF/5 human hepatoma cell line. The effect on cell growth and HBsAg production of Cordycepin, 6-azauridine, and Hygromicin B is reported. Hygromicin B, a translation inhibitor unable to penetrate normal cells, greatly reduced HBsAg production by growing and confluent cells.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001380:Azauridine / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000276:immunology* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003839:Deoxyadenosines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006514:Hepatitis B Surface Antigens; D006801:Humans; D006921:Hygromycin B / Q000494:pharmacology*; D008113:Liver Neoplasms
D000900:Anti-Bacterial Agents; D003839:Deoxyadenosines; D006514:Hepatitis B Surface Antigens; D006921:Hygromycin B; D001380:Azauridine