title: [DNA metabolism in the process of the maturation of male sex cells. I. Amplification of ribosomal genes in the spermatogenesis of rats].
abstract: It has been shown that amplification of ribosomal genes takes place in prophase I of rat spermatogenesis. At the pachytene I step, a 2-fold excess of rDNA was found. Amplification of ribosomal genes starts in the premeiotic interphase on the chromosomal DNA. At the initial stage of rDNA amplification, a rDNA-RNA hybrid was detected. Our results allow the suggestion to be made that RNA plays the role of a primer in synthesis of the excess rDNA. It is possible that AT-rich prenucleolar DNA is involved in amplification of rDNA.
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004275:DNA, Ribosomal; D005784:Gene Amplification; D005796:Genes; D008297:Male; D009693:Nucleic Acid Hybridization; D011418:Prophase; D012313:RNA / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains; D012270:Ribosomes / Q000378:metabolism / Q000648:ultrastructure*; D012741:Sexual Maturation; D013091:Spermatogenesis
chemical_list: D004275:DNA, Ribosomal; D012313:RNA; D004247:DNA
vernacular_title: Metabolizm DNK v protsesse sozrevaniia muzhskikh polovykh kletok. Soobshchenie I. Amplifikatsiia ribosomnykh genov v spermatogeneze krys.