title: Results, problems and perspectives with the autoregulating pacemaker.
abstract: Experimental in vitro testing coupled with animal and clinical studies have shown that a pH sensor may sense acute changes in pH occurring in response to exercise. This signal may in turn be used as a determinant for optimal pacing rate. Further investigation into membrane coating of electrodes and algorithm testing is necessary to maximize sensor response and control.
mesh_terms: D000203:Activities of Daily Living; D000818:Animals; D004562:Electrocardiography; D004567:Electrodes, Implanted; D004699:Endocardium / Q000378:metabolism / Q000648:ultrastructure; D005071:Evoked Potentials; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007495:Iridium / Q000627:therapeutic use; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D010138:Pacemaker, Artificial; D012834:Silver / Q000627:therapeutic use
chemical_list: D012834:Silver; D007495:Iridium