CCl4-hepatotoxicity in the Mongolian gerbil: influence of monooxygenase system induction.
The effects of chlordecone (CD), mirex or phenobarbital (PB) treatment of male Mongolian gerbils on CCl4-hepatotoxicity were determined. These monooxygenase inducers did not potentiate CCl4-hepatotoxicity in the gerbil although phenobarbital and CD are known potentiators in the rat. The control gerbil was more sensitive to CCl4-hepotoxicity than the control rat as reflected in loss of cytochrome (cyt) P-450 and increases in SGOT and SGPT. In addition, CCl4 treatment of the control gerbils resulted in significant reductions in cyt b5 and NADPH-cyt P-450 levels, a phenomenon not observed in the rat.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D007631:Chlordecone / Q000494:pharmacology; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D004790:Enzyme Induction; D005849:Gerbillinae; D008099:Liver / Q000201:enzymology*; D008297:Male; D008917:Mirex / Q000494:pharmacology; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology
D003573:Cytochrome b Group; D015786:Cytochromes b5; D006899:Mixed Function Oxygenases; D009251:NADPH-Ferrihemoprotein Reductase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007631:Chlordecone; D010634:Phenobarbital; D008917:Mirex