Intradermal histamine release by 3 muscle relaxants.
The induration and redness caused by intradermal injections of equipotent doses of atracurium, vecuronium and d-tubocurarine were measured in six healthy, male volunteers. Atracurium and d-tubocurarine were almost indistinguishable in their reactions. Vecuronium caused a significantly smaller response than both atracurium and d-tubocurarine. We therefore suggest that of these three drugs, vecuronium may cause the least histamine release and is, perhaps, the drug of choice in patients with a history of asthma or allergy.
D000328:Adult; D001279:Atracurium; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007273:Injections, Intramuscular; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010197:Pancuronium / Q000031:analogs & derivatives / Q000494:pharmacology; D014403:Tubocurarine / Q000494:pharmacology; D014673:Vecuronium Bromide
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D014673:Vecuronium Bromide; D010197:Pancuronium; D014403:Tubocurarine