Induction of murine alpha-foetoprotein synthesis by oestradiol.
The synthesis of murine alpha-foetoprotein (m-AFP) was induced in 43 out of 47 adult mice of both sexes by sc administration of 100 micrograms oestradiol-17 beta every second day. The m-AFP serum levels of the oestrogen treated male and female mice were 7 and 17%, respectively, of the levels in mice during late pregnancy. Immunohistochemical examination of liver tissue revealed the intracellular presence of m-AFP in less than 0.5% of the hepatocytes scattered throughout the liver of the oestrogen treated mice.
D000818:Animals; D002846:Chromatography, Affinity; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007123:Immunoelectrophoresis, Two-Dimensional; D007124:Immunoenzyme Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins; D004958:Estradiol