title: Extracellular matrix during laminar pattern formation of neocortex in normal and reeler mutant mice.
abstract: The spatial and temporal distribution of extracellular matrix, which occupied the large extracellular spaces in the developing cerebral cortex, was studied during pre- and perinatal ontogenesis of normal and reeler mutant mice. Colloidal iron-staining material was localized principally in the marginal zone and subplate of normal mice, whereas in reeler mutants, most of the material was found in the outer layers of the cortex. Patterns of extracellular matrix localization in both genotypes followed the laminar pattern formation of cerebral cortex architecture. Histochemical ultrastructural visualization of this extracellular matrix and its susceptibility to enzymatic treatment suggested that the major components are glycosaminoglycans. Their possible role in relation to afferent axon targeting is discussed.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000196:embryology* / Q000378:metabolism / Q000648:ultrastructure; D003102:Colloids; D005110:Extracellular Space / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism; D006651:Histocytochemistry; D007501:Iron; D051379:Mice; D008818:Mice, Neurologic Mutants; D008854:Microscopy, Electron; D013194:Staining and Labeling
chemical_list: D003102:Colloids; D006025:Glycosaminoglycans; D007501:Iron