title: Rhinitis medicamentosa. An experimental histopathological and histochemical study.
abstract: The deleterious effects of decongestant drops on the respiratory nasal mucosa of guinea pigs were studied histopathologically and histochemically. The histopathological changes included: initial goblet cell hyperplasia, squamous metaplasia, increased vascularity, oedema of the corium, mononuclear cellular infiltration and glandular hyperplasia. The histochemical changes indicated: increased secretory activity, increased phagocytic activity as well as disturbance of the vasomotor response.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004950:Esterases / Q000378:metabolism; D006168:Guinea Pigs; D006965:Hyperplasia; D008679:Metaplasia; D014663:Nasal Decongestants / Q000009:adverse effects*; D009297:Nasal Mucosa / Q000201:enzymology / Q000473:pathology; D012220:Rhinitis / Q000139:chemically induced*; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D014663:Nasal Decongestants; D013385:Succinate Dehydrogenase; D004950:Esterases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase