Enhancing effect of dextran sulfate sodium on colorectal carcinogenesis by 1,2-dimethylhydrazine in rats.
Four groups were used, each consisting of 24 male ACI rats. Group I received a single subcutaneous injection of 20 mg 1,2-dimethylhydrazine (DMH)/kg body weight and was fed on basal diet until the termination of the experiment. Group II received the same single injection as in group I and then, starting one week later, was fed the diet containing 1% dextran sulfate sodium (DS-M-1). Group III received an injection of 0.9% sodium chloride and then DS-M-1 diet. The control group was given neither DMH nor DS-M-1 diet. The experiment was terminated after 40 weeks. A significantly higher incidence of colorectal carcinoma was observed in group II, as compared with group I (P less than 0.02). These data demonstrate the enhancing effect of DS-M-1 on colorectal carcinogenesis.
D019813:1,2-Dimethylhydrazine; D000230:Adenocarcinoma / Q000139:chemically induced; D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D003043:Cocarcinogenesis; D003110:Colonic Neoplasms / Q000139:chemically induced*; D016264:Dextran Sulfate; D003911:Dextrans / Q000494:pharmacology*; D004127:Dimethylhydrazines / Q000633:toxicity*; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D008970:Molecular Weight; D051381:Rats; D011912:Rats, Inbred ACI; D012004:Rectal Neoplasms / Q000139:chemically induced*
D003911:Dextrans; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D016264:Dextran Sulfate; D019813:1,2-Dimethylhydrazine