Acrylic microspheres in vivo VIII: distribution and elimination of polyacryldextran particles in mice.
The disposition of different 14C-labeled, biodegradable polyacryldextran microparticles after intravenous injection has been studied in the mouse. The particles were rapidly cleared from the circulatory system by the reticuloendothelial system. They were predominantly (60-80%) found in the liver and spleen and to some extent in the bone marrow. Large particle aggregates were found in the lungs 6 hr postinjection. After redistribution, the particles were eliminated from the organs with an apparent t 1/2 of 12-30 weeks, depending on the composition of the particles. Highly cross-linked particles with 2% acrylic groups (DTC = 11-2-75) had a half-life similar to that of polyacrylamide particles (TC = 8-25). The metabolism rate was also correlated with the degradation in vitro with isolated rat lysosomes. After intravenous injection of small 14C-labeled polyacrylamide particles (0.2-0.5 micron), significant amounts of radioactivity were detected in the bile and gallbladder.
D000180:Acrylic Resins / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001646:Bile / Q000378:metabolism; D003911:Dextrans / Q000378:metabolism*; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D051379:Mice; D008863:Microspheres; D010316:Particle Size; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000180:Acrylic Resins; D003911:Dextrans; C026074:polyacryldextran