Bidirectional axonal transport of thallium in frog sciatic nerve.
Bidirectional axonal transport of radioactivity was demonstrated in frog sciatic nerve in vitro and in vivo after local application of the thallium isotope 204Tl+ to the nerve. The transport rate was similar in both directions and about 30 min/day at 18 degrees C. The transport was depressed by 2,4-DNP, low-temperature and vinblastine. A somewhat larger amount of radioactivity was transported in the retrograde than in the anterograde direction. The possibility that K+ is in part replaced by Tl+, which is transported bound to organelles, e.g. mitochondria, will be considered. Thallium might be a useful tool for future studies of axonal transport.
D019297:2,4-Dinitrophenol; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D004140:Dinitrophenols / Q000494:pharmacology; D011868:Radioisotopes; D011896:Rana temporaria; D012584:Sciatic Nerve / Q000502:physiology*; D013793:Thallium; D014747:Vinblastine / Q000494:pharmacology
D004140:Dinitrophenols; D011868:Radioisotopes; D014747:Vinblastine; D013793:Thallium; D019297:2,4-Dinitrophenol