Immunomodulatory drugs as the stimulators of proliferative process.
Stimulatory effect of immunomodulators on cellular proliferation was studied on the experimental model of regenerating rat liver. Thymus factor (TFX), isoprinosine and, to a lesser degree, levamisole, were observed to accelerate and enhance a compensative hypertrophy of the remaining lobes of liver. This phenomenon concerns mainly parenchymatous liver cells but also nonparenchymal system. A suggestion was put forward that a therapeutic effect of thymus factor in viral hepatitis cases is exerted not only through its immunotropic component but also through its capability to stimulate cell renewal. The above indicated the possibility of utilization in such cases of other immunomodulators, mainly of isoprinosine.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D005260:Female; D007542:Inosine Pranobex / Q000494:pharmacology; D007978:Levamisole / Q000494:pharmacology; D008115:Liver Regeneration / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013949:Thymus Extracts / Q000494:pharmacology
D000276:Adjuvants, Immunologic; C019108:TFX; D013949:Thymus Extracts; D007978:Levamisole; D007542:Inosine Pranobex