Effect of disodium cromoglycate and cyclic AMP-active drugs on cytotoxic histamine release from rat mast cells.
Disodium cromoglycate and compounds which elevated levels of cyclic AMP in the mast cell variously inhibited cytotoxic histamine release induced by the surface active agents melittin, Tween 20 and Triton X-100. These results are inconsistent with the postulated effects of the drugs on receptor mediated calcium channels and alternative explanations of their action are considered.
D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000242:Cyclic AMP; D004205:Cromolyn Sodium