Coexistence of immunoreactive substance P and serotonin in neurones of the gut.
Serotonin (5-HT) and substance P (SP) were visualized by indirect immunofluorescence using two fluorochromes applied sequentially on the same preparation of myenteric plexus from the guinea pig gut. Three groups of labelled neurones were found: (i) neurones with 5-HT-like immunoreactivity only; (ii) neurones with SP-like immunoreactivity only; (iii) neurones with both 5-HT- and SP-like immunoreactivity, which represented approximately one-third of the 5-HT-like immunoreactive neurones.
D000818:Animals; D003106:Colon / Q000294:innervation*; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D009197:Myenteric Plexus / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
D012701:Serotonin; D013373:Substance P