[Nucleic acid and protein biosynthesis in the androgen-sensitive organs of intact male rats given the nonsteroid antiandrogen niftolide].
In experiments on adult male rats it was found that the oral injection of non-steroid antiandrogen 4-nitro-3-trifluoromethylisobutyranilide (niftolide) in a dose of 25 mg/kg during 8 or 30 days induces atrophy of the accessory genital glands and the levator ani muscle and a decrease in the nucleic acid and protein content. Niftolide "castration" effect is realized through its ability to inhibit biosynthesis of these compounds in androgen-sensitive organs. The antiandrogen dose used exerted a potent prolonged antiandrogenic action, despite its stimulating effect upon the hypothalamic-hypophyseal-gonadal system.
D001003:Anal Canal; D000726:Androgen Antagonists / Q000008:administration & dosage*; D000813:Anilides / Q000008:administration & dosage*; D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D005485:Flutamide / Q000008:administration & dosage*; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D000726:Androgen Antagonists; D000813:Anilides; D012313:RNA; D005485:Flutamide; D004247:DNA
Biosintez nukelinovykh kislot i belka v androgenchuvstvitel'nykh organakh intaktnykh samtsov krys v usloviiakh vvedeniia nesteroidnogo antiandrogena niftolida.