Hyperglucagonemia--a partial explanation for the increased amylase/creatinine clearance in pancreatitis.
Hyperglucagonemia accompanies several clinical conditions characterized by increased amylase/creatinine clearance. We tested the hypothesis that glucagon may be responsible for this augmented clearance. Therefore, a constant glucagon infusion was given to eight volunteers in order to attain physiological levels comparable to those obtained during acute pancreatitis. The amylase/creatinine clearance increased from 0.84 +/- 0.8% to a mean of 1.30 +/- 1.14% (p less than 0.001). This was, however, less than the clearance of 2.94 +/- 0.23% observed during acute pancreatitis. The rise in amylase clearance during acute pancreatitis is, therefore, only partially explained by the hyperglucagonemia.
D000208:Acute Disease; D000328:Adult; D000681:Amylases / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism*; D005934:Glucagon / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D010195:Pancreatitis / Q000378:metabolism*
D005934:Glucagon; D003404:Creatinine; D000681:Amylases