Interferon and prostaglandins: effects on human natural and lectin-induced cytotoxicity.
Effects of interferons (IFN) and E-series prostaglandins (PGE) were evaluated on subpopulations of human peripheral blood mononuclear lymphocytes (PBL) that mediate natural killer (NK) activity, antibody-dependent cell-mediated cytotoxicity (ADCC), or lectin-induced cellular cytotoxicity (LICC). When PBL were separated into subpopulations depending on the presence or absence of receptors for sheep erythrocytes (E+ or E-, respectively) or for the Fc gamma receptor (Fc gamma R+ or Fc gamma R-, respectively), LICC was mainly associated with the E+Fc gamma R- cells and to a considerably lesser extent with E+Fc gamma R+ cells. In contrast, NK activity and ADCC were associated with the E+ and E- subpopulations that had Fc gamma R. IFN treatment had stronger effects on the Fc gamma R+ subpopulations. Boosting of LICC occurred maximally in the E+Fc gamma R+ subpopulation, and the activity of the E+Fc gamma R- cells increased only modestly. IFN had a greater augmenting effect on the NK activity and ADCC of E+Fc gamma R+ cells than on E-Fc gamma R+ cells. PGE strongly inhibited all three types of cell-mediated cytotoxicity and was effective on IFN-boosted cells as well as on untreated cells.
D000920:Antibody-Dependent Cell Cytotoxicity; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D037102:Lectins / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D011458:Prostaglandins E / Q000494:pharmacology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D037102:Lectins; D011458:Prostaglandins E; D007372:Interferons