Prenatal detection of the congenital nephrotic syndrome (Finnish type) by trehalase assay in amniotic fluid.
We report relatively high trehalase activity in the amniotic fluid of two fetuses affected with the congenital nephrotic syndrome of the Finnish type. The results suggest that prenatal detection of this condition can be done on this basis in conjunction with the alpha-fetoprotein and acetylcholinesterase tests in amniotic fluid.
D000110:Acetylcholinesterase / Q000032:analysis; D000653:Amniotic Fluid / Q000201:enzymology*; D004186:Disaccharidases / Q000032:analysis; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D009404:Nephrotic Syndrome / Q000151:congenital* / Q000235:genetics; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014198:Trehalase / Q000032:analysis*; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins; D000110:Acetylcholinesterase; D004186:Disaccharidases; C022310:palatinase; D014198:Trehalase