title: Cyclic eosinophilic leukocytosis in eosinophilic leukemia with observations on transcobalamin I and eosinophils.
abstract: A patient with eosinophilic leukemia was noted to have spontaneous fluctuations in his eosinophil and total leukocyte counts over a 3-year period. The range of eosinophil counts observed was from 736/microliters to 401,400/microliters. Sharp fluctuations occurred whether chemotherapy was administered at the nadir or the peak of a cycle or was withheld. A shortening of the cycle length from 44 to 25 days, and a marked increase in amplitude of the cycle occurred in the terminal phase of his illness. Two additional observations merit mention. An abnormal alpha-2 globulin of 40,000 molecular weight was detected in his serum. In addition, cyclic fluctuations of serum transcobalamin I that accompanied his cyclic eosinophil counts were noted, and eosinophils were documented for the first time to be rich sources of this protein.
mesh_terms: D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis; D003131:Combined Modality Therapy; D004802:Eosinophilia / Q000097:blood* / Q000628:therapy; D004804:Eosinophils; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000628:therapy; D007958:Leukocyte Count; D008297:Male; D008970:Molecular Weight; D009504:Neutrophils; D014155:Transcobalamins / Q000378:metabolism*
chemical_list: D000510:Alpha-Globulins; D014155:Transcobalamins