Adaptive reaction of nigral neurons following lesion of their ventromedial-thalamic projection field.
The response of reticulata-nigral neurons to injury of their ventromedial-thalamic (VM) projection was studied in the rat, by the autoradiographic [14C]deoxyglucose method. Electrolytic lesion of the VM induced reversible: reticulata hypoexcitability; and hyporesponsiveness of areas receiving reticulata efferents, to nigral electrical stimulus. The results suggest that distal axonal injury (in the VM) induces reversible rearrangement of functional properties in the nigral parent cells and their uninjured collaterals, as a retrograde reaction.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport; D002250:Carbon Radioisotopes; D003847:Deoxyglucose / Q000378:metabolism; D007839:Functional Laterality; D008297:Male; D009474:Neurons / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*
D002250:Carbon Radioisotopes; D003847:Deoxyglucose