Resistant gestational choriocarcinoma: successful treatment with vinblastine, bleomycin, and cisplatin (VBP).
Two patients with resistant gestational trophoblastic neoplasms were treated with vinblastine, bleomycin, and cisplatin (Einhorn regimen). Both patients had failed multiple conventional therapeutic regimens including methotrexate, dactinomycin, high-dose methotrexate, and the modified Bagshawe regimen. Both patients achieved complete remissions and remain free of disease at 20 and 33 months following completion of therapy. The combination of vinblastine, bleomycin, and cisplatin is highly active in patients with resistant gestational trophoblastic neoplasms, and should be used as second-line therapy for poor-prognosis patients failing initial treatment.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin / Q000008:administration & dosage*; D002822:Choriocarcinoma / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000601:surgery; D014747:Vinblastine / Q000008:administration & dosage*
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin