Preservation of platelet function in cryopreserved platelet concentrates with prostacyclin.
Prostacyclin (Epoprostenol) or a stable prostacyclin analogue (ZK 36,374) were added to platelet concentrates prior to cryopreservation. This resulted in significantly better preserved function of the thawed platelet concentrate, assessed by platelet aggregation to various concentrations of ADP, collagen and ristocetin, compared to control cryopreserved platelet concentrates. The use of prostacyclin or one of its stable analogues should be considered to reduce platelet activation and subsequent loss of function during the various manipulative procedures when preparing standard and cryopreserved platelet concentrates.
D001792:Blood Platelets / Q000502:physiology*; D001793:Blood Preservation / Q000379:methods*; D011464:Epoprostenol / Q000494:pharmacology; D005615:Freezing; D006801:Humans; D016285:Iloprost; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects
D011464:Epoprostenol; D016285:Iloprost