Targeting of antiviral drugs by coupling with protein carriers.
Side effects of antiviral drugs might be circumvented by their selective delivery into infected cells. This targeting can be obtained by conjugation of the drugs to macromolecules which are taken up specifically by the infected cells. The experiments reviewed, on this approach to antiviral chemotherapy, are mainly directed at improving the chemotherapeutic index of adenine arabinoside (ara-A) in the treatment of chronic hepatitis B by its coupling to galactosyl terminating glycoproteins.
D000418:Albumins / Q000008:administration & dosage*; D000546:Amanitins / Q000008:administration & dosage; D000606:Amino Sugars; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001212:Asialoglycoproteins; D055598:Chemical Phenomena; D002621:Chemistry; D003561:Cytarabine / Q000008:administration & dosage; D004261:DNA Replication / Q000187:drug effects; D004481:Ectromelia virus / Q000187:drug effects / Q000254:growth & development; D060748:Fetuins; D005467:Floxuridine / Q000008:administration & dosage; D006023:Glycoproteins / Q000008:administration & dosage*; D006509:Hepatitis B / Q000188:drug therapy; D006515:Hepatitis B virus / Q000254:growth & development; D006801:Humans; D008099:Liver / Q000166:cytology / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology; D012709:Serum Albumin / Q000008:administration & dosage; D014271:Trifluridine / Q000008:administration & dosage; D014740:Vidarabine / Q000008:administration & dosage; D014779:Virus Replication / Q000187:drug effects; D000509:alpha-Fetoproteins / Q000008:administration & dosage
D000418:Albumins; D000546:Amanitins; D000606:Amino Sugars; D000998:Antiviral Agents; D001212:Asialoglycoproteins; D060748:Fetuins; D006023:Glycoproteins; D012709:Serum Albumin; D000509:alpha-Fetoproteins; C017029:asialofetuin; D005467:Floxuridine; D003561:Cytarabine; C032233:lactosamine; D014740:Vidarabine; D014271:Trifluridine