Plasmacytoid T-cell clusters in non-specific lymphadenitis.
The occurrence and morphology of Lymphoblastennester (clusters of lymphoblasts) were analyzed in 500 unselected cases of nonspecific lymphadenitis. Sixty-eight cases showed such clusters, which consist of uniform-looking medium-sized cells. Based on the results of recent immunologic investigations, these cells may be interpreted as T-cells with plasmacytoid features ("plasmacytoid T-cells', PTC). PTC were usually located near venules in the pulp, but not in the generally hyperplastic T-nodules. There was usually no relation to hyperplasia of B-regions (follicles). Although occasional mitotic figures and basophilic blast cells were found at the edges of PTC clusters, it is possible that PTC develop through transformation of T-lymphocytes. PTC often showed pyknotic nuclei and a tendency to perish, suggesting that they are end cells. Necrotic cells were phagocytosed by macrophages, which occasionally caused a starry sky pattern like that seen in germinal centers. Sometimes there were also a few interdigitating reticulum cells in the clusters. The function of PTC is still obscure; they might secrete lymphokines.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002467:Cell Nucleus; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000473:pathology*; D008264:Macrophages; D008297:Male; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000473:pathology; D010587:Phagocytosis; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000473:pathology*