Intra- and extraneuronal monoamine oxidase.
By use of monoamine reuptake inhibitors, it is possible to study the intra- and extraneuronal components of monoamine deamination in brain. In both man and rat, the ratios of activities of MAO-A/MAO-B are higher intra- than extraneuronally . As a result of this difference in cellular localisation in the brain, loss of neurones produces a change in the ratios of activities of MAO-A/MAO-B. It is also possible selectively to inhibit the activity of MAO-A within a given neurone population. The alpha-methyl substituted monoamine amiflamine has been shown to inhibit MAO-A within serotoninergic neurones at lower doses than are required for inhibition in other neurones. The usefulness of this compound in the elucidation of the functions of intra- and extraneuronal MAO are discussed.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002478:Cells, Cultured; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism* / Q000502:physiology; D010624:Phenelzine / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000201:enzymology
D010627:Phenethylamines; D011954:Receptors, Dopamine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008995:Monoamine Oxidase; C031466:amiflamine; D010624:Phenelzine; D004298:Dopamine