[Human yolk sac tumor of the thymus heterotransplanted into nude mice].
A human yolk sac tumor of the thymus (YSK-1) was transplanted into athymic nude mice. Histological and ultrastructural investigations revealed that the YSK-1 tumor, even after serial transplantation in nude mice, characteristically displayed Schiller-Duval bodies, endodermal sinus structures and ultrastructural profiles, numerous microvilli, desmosome-like cell attachments, annulate lamellar structures, many lipid droplets and interspersed glycogen particles. Serological study by radioimmunoassay demonstrated AFP, CEA, HCG, alpha 1-AT and transferrin in the sera and cyst fluid of the tumor-bearing nude mice. Immunohistochemical investigation using the PAP method showed that the YSK-1 cells produced CEA, HCG, alpha 1-AT, transferrin as well as AFP. The increase in the level of AFP paralleled the increase in tumor size.
D000328:Adult; D000818:Animals; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000097:blood; D006801:Humans; D008297:Male; D008649:Mesonephroma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013953:Thymus Neoplasms / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D014183:Transplantation, Heterologous; D000509:alpha-Fetoproteins / Q000032:analysis
D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins