title: Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.
abstract: Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology*; D000914:Antibodies, Viral / Q000032:analysis; D001853:Bone Marrow / Q000382:microbiology; D002140:California; D002460:Cell Line; D002478:Cells, Cultured; D003429:Cross Reactions; D003588:Cytopathogenic Effect, Viral; D017977:Deltaretrovirus / Q000276:immunology / Q000302:isolation & purification* / Q000502:physiology / Q000648:ultrastructure; D006716:Homosexuality; D006801:Humans; D007962:Leukocytes / Q000382:microbiology; D008206:Lymphatic Diseases / Q000276:immunology; D008297:Male; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013577:Syndrome; D013601:T-Lymphocytes; D014776:Virus Cultivation
chemical_list: D000914:Antibodies, Viral; D012194:RNA-Directed DNA Polymerase