Comparative studies with Fluosol, Dextran, their mixture, or autologous blood in experimental hypovolemic shock.
In 42 rabbits blood pressure was held at 40 mmHg/15 min. Various treatments resulted in equal recovery from shock in 4 groups. There is, however, some evidence that: (1) Dextran 40 was superior regarding microcirculation; (2) Fluosol added more oxygen to the tissues; and (3) a combined treatment showed both effects.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes / Q000494:pharmacology*; D001804:Blood Transfusion, Autologous; D003911:Dextrans / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology* / Q000627:therapeutic use; D006895:Hydroxyethyl Starch Derivatives; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D010100:Oxygen / Q000097:blood; D011817:Rabbits; D012769:Shock / Q000188:drug therapy / Q000503:physiopathology*
D001802:Blood Substitutes; D003911:Dextrans; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D007773:Lactates; D019344:Lactic Acid; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D010100:Oxygen