Inhibition of renin in the primate Callithrix jacchus (common marmoset).
The effects of an antiserum against human kidney renin and of H-142, a peptide inhibitor of human renin, were studied in the primate Callithrix jacchus (common marmoset). In severely volume-depleted (low-salt diet and repetitive injections of furosemide), conscious marmosets, the antiserum reduced blood pressure to the same extent as the converting enzyme inhibitor teprotide (-31 +/- 7 SEM mmHg and -30 +/- 5 mmHg). In mildly volume-depleted (normal salt diet and single injection of furosemide), conscious marmosets, H-142 and teprotide induced a similar fall in blood pressure (-14 +/- 4 mmHg and -15 +/- 2 mmHg). When H-142 was infused after the injection of teprotide, it had no further effect on blood pressure. Conversely, teprotide was ineffective when injected during the infusion of H-142. These results show that in marmosets blood pressure can be lowered by specific inhibitors of human renin. A converting-enzyme inhibitor has similar effects. Hence the renin-angiotensin system appears to contribute significantly to the maintenance of blood pressure in conscious, volume-depleted marmosets.
D000808:Angiotensinogen / Q000031:analogs & derivatives*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002143:Callitrichinae; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D010455:Peptides / Q000494:pharmacology; D012083:Renin / Q000276:immunology; D013722:Teprotide / Q000494:pharmacology; D013997:Time Factors; D000092502:Renin Inhibitors
D000808:Angiotensinogen; D007106:Immune Sera; D010455:Peptides; D012083:Renin; D013722:Teprotide; D000092502:Renin Inhibitors; C039583:H 142