A predominant idiotype on rabbit anti-VH a1 allotype antibodies: sharing by both major and minor VH subgroups.
In every rabbit examined, greater than or equal to 80% of antibodies directed against the VH allotypic marker, a1, bears a predominant idiotype (IdX-a1). The IdX-a1 marker is site-associated and expressed on H chains, but not L chains, of anti-a1 antibody. Experiments using rabbits suppressed for the VH a subgroup demonstrated that IdX-a1 can be associated with both major (a+) and minor (a-) VH subgroup gene products and that a1 rabbits contain IdX-a1 within their genetic repertoire. The genetic and regulatory implications of our results are discussed.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000939:Epitopes; D005786:Gene Expression Regulation; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D007143:Immunoglobulin Heavy Chains / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000235:genetics / Q000276:immunology*; D007147:Immunoglobulin Light Chains / Q000276:immunology; D007135:Immunoglobulin Variable Region / Q000276:immunology; D011817:Rabbits
D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D007126:Immunoglobulin Allotypes; D007143:Immunoglobulin Heavy Chains; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region