Transmission of cytomegalovirus among infants in hospital documented by restriction-endonuclease-digestion analyses.
Over a 4-month period, 8 infants in an intensive-care unit were identified as excreting cytomegalovirus (CMV) in their urine. 7 of the 8 viral isolates were analysed by means of restriction-endonuclease-digestion analyses for molecular relatedness. CMV isolates from 3 babies had identical DNA-fragment migration patterns, indicating that all 3 babies were infected with the same strain of CMV. Epidemiological data indicate that CMV was transmitted from 1 infant to the other 2 babies through unidentified fomites within the nursery.
D003428:Cross Infection / Q000635:transmission*; D003587:Cytomegalovirus / Q000201:enzymology* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000635:transmission*; D004262:DNA Restriction Enzymes / Q000032:analysis*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007223:Infant; D007362:Intensive Care Units; D008297:Male; D012306:Risk; D013194:Staining and Labeling; D014556:Urine / Q000382:microbiology*
D004262:DNA Restriction Enzymes