Basophilic deposits in the stria vascularis. A clinicopathological update.
Basophilic deposits in the stria vascularis have been found in association with a multitude of disease entities. Their true significance and nature remain obscure. In the temporal bone collection at the Massachusetts Eye and Ear Infirmary are 22 cases with basophilic deposits in the stria vascularis. The ages of the subjects studied ranged from two days to 83 years. Atrophy of the stria vascularis was the main pathology seen in their temporal bones. The deposits were found in both ears in 82% of cases. They tend to show a striking polymorphism. Special histochemical stains suggest they contain glycogen. Hypertension and uremia were two health problems most of the subjects were suffering from during life. A theory is advanced as to the immune complex nature of these deposits. A review of the literature concerning this subject is also offered.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy; D001491:Basophils / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003051:Cochlea / Q000473:pathology*; D004427:Ear Diseases / Q000473:pathology; D005260:Female; D006003:Glycogen / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling; D013316:Stria Vascularis / Q000032:analysis / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology; D014511:Uremia / Q000150:complications
D006003:Glycogen