Total parenteral nutrition inhibits intestinal adaptive hyperplasia in young rats: reversal by feeding.
To determine whether the inhibition of intestinal adaptation by total parenteral nutrition (TPN) in young growing animals is reversible, 130 7-week-old rats with 70% resection of the midportion of the small bowel were given an amino acid and glucose TPN solution parenterally or orally or a chow diet for 10 days. After TPN administration, villous height, crypt depth, DNA and RNA content, RNA:DNA ratio, and sucrase activity were decreased. After returning to 4 weeks of chow feeding, rats given TPN achieved similar body weight and 15% greater intestinal length as compared with rats fed chow from the start, although their jejunal villous height, ileal crypt depth, and RNA:DNA were decreased. Therefore, the inhibition by TPN of intestinal adaptation after intestinal resection in young growing rats is largely reversible. Furthermore, oral feeding of a high-calorie, high-protein liquid diet before feeding of a normal diet appears to promote adaptation after intestinal resection in immature, growing rats.
D000222:Adaptation, Physiological; D000818:Animals; D001835:Body Weight; D004247:DNA / Q000032:analysis; D005502:Food; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000032:analysis / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012313:RNA / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013393:Sucrase / Q000032:analysis; D013997:Time Factors
D012313:RNA; D004247:DNA; D013393:Sucrase