Comparison of antigens in the rat MHC that act as CML determinants.
We have examined a variety of RT1 haplotypes using congenic strains of rats to investigate the comparative relationships among MHC antigens that have been reported to serve as cell-mediated lympholysis (CML) targets. These studies demonstrate that: (1) RT1.A antigens can act as CML determinants, and in some haplotypes they display identical serological and CML reaction patterns; (2) in some donor-recipient strain combinations RT1.A antigens may act as immunodominant determinants, preventing the generation of effectors capable of recognizing other antigens, and (3) a portion of the antigenic determinants that define the anti-CT CML response can be mapped to the same region of the rat MHC as the RT1.E locus.
D000818:Animals; D000941:Antigens / Q000235:genetics*; D003429:Cross Reactions; D000939:Epitopes; D008285:Major Histocompatibility Complex; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000941:Antigens; D000939:Epitopes