The effect of H1 and H2 receptor antagonists on the dermographic response.
The effect on dermographic wealing of an H1 and H2 receptor antagonist was studied separately and in combination. a double-blind protocol was used and dermographism was measured as the diameter of weal response to a measured force. Both H1 and H2 antagonists had a small but non-significant effect, but the combination of H1 plus H2 antagonist had an approximately additive effect which was significant. Although this indicates a role for H2 receptors in dermographism it does not establish the degree of involvement, nor whether H2 antagonists necessarily have any advantage over a potent H1 blocker alone in the treatment of dermographism.
D000328:Adult; D002744:Chlorpheniramine / Q000008:administration & dosage*; D002927:Cimetidine / Q000008:administration & dosage*; D004311:Double-Blind Method; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006146:Guanidines / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D014581:Urticaria / Q000188:drug therapy*
D006146:Guanidines; D002744:Chlorpheniramine; D002927:Cimetidine