Effects of kola-nut extract administration on the liver, kidney, brain, testis and some serum constituents of the rat.
Kola-nut extract induced a number of overt neurotoxicological signs in male albino rats. A decrease in the total body weight and an increase in the absolute weights of the liver, kidney, brain and testis were observed after 18 weeks oral administration of kola-nut extract to the rats. Total protein, RNA and DNA of these organs were significantly depressed. The activity of beta-glucuronidase and beta-galactosidase was induced only in the kidney, brain and testis of treated animals. While the levels of serum phosphomonoesterases and total cholesterol were significantly enhanced due to kola-nut intake, serum total and conjugated bilirubin levels were significantly decreased.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects; D001616:beta-Galactosidase / Q000378:metabolism
D010936:Plant Extracts; D011506:Proteins; D012313:RNA; D004247:DNA; D001616:beta-Galactosidase; D005966:Glucuronidase