[Morphological studies of the effect of substance P partial sequences on nerve tissue culture].
Explants of the telencephalon and of the ganglion trigeminale from chick embryos were cultivated in the presence of 10(-7) M of substance P partial sequences SP 1-2 (Arg-Pro . 22HCl) and SP3-4 (Lys(Z)-Pro . HCl or Lys-Pro . 2HBr). The morphology of the living outgrowth in fact the growth of nerve fibers, cell migration and proliferation was observed. SP1-2 and SP3-4 influenced particularly the morphology of pns cultures.
D000818:Animals; D002455:Cell Division; D002465:Cell Movement; D002642:Chick Embryo; D046508:Culture Techniques; D004151:Dipeptides / Q000494:pharmacology*; D008858:Microscopy, Phase-Contrast; D009417:Nerve Tissue / Q000166:cytology / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology*; D013687:Telencephalon; D012668:Trigeminal Ganglion
D004151:Dipeptides; C039357:arginylproline; D013373:Substance P; C039356:lysylproline
Morphologische Untersuchungen über die Wirkung von Substanz P-Teilsequenzen auf Nervengewebekulturen.