title: Effect of cortisone on the behavior of serotonin, 5-hydroxy-indoloacetic acid and monoaminooxidase in the liver tissue, the blood and the urine in experimental rabbit liver injury with CCl4.
abstract: The aim of this study was to investigate the effect of cortisone on the behavior of serotonin metabolism indicators in experiments carried out in rabbits. The following parameters were determined: the level of serotonin (5-hydroxy-tryptamine), (5-HT) in liver tissue and blood, the activity of monoamino-oxidase (MAO) in liver tissue and serum, and the level of 5-hydroxy-indoloacetic acid (5-HIAA) in liver tissue and in 24-hour urine of 52 rabbits. The experimental model involved acute liver injury with carbon tetrachloride--CCl4 and the effect of exogenous cortisone on the behavior of the above-mentioned indicators. On the basis of the experimental findings the authors demonstrate a dependence of serotonin metabolism on the liver injury, and an absence of normalization of the estimated parameters after cortisone administration.
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury; D003348:Cortisone / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood*; D011817:Rabbits; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D002251:Carbon Tetrachloride; D008995:Monoamine Oxidase; D003348:Cortisone