Serum alpha-1 antichymotrypsin is a possible growth inhibitor of Plasmodium falciparum.
Serum protease inhibitors were determined in paired sera from 7 patients with cerebral malaria and 2 patients with acute malaria showing high and low growth inhibition activity in the initial and follow-up sera respectively. Alpha-1 antichymotrypsin and alpha-1 antitrypsin but not alpha-2 macroglobulin showed direct correlation with the growth inhibition activity. When alpha-1 antitrypsin was deliberately added to the malarial culture no growth inhibition occurred indicating that the alpha-1 antichymotrypsin was the most likely factor responsible for inhibition of growth of malarial parasites in vitro.
D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000097:blood; D006131:Growth Inhibitors / Q000378:metabolism*; D006801:Humans; D008288:Malaria / Q000097:blood / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000378:metabolism; D011480:Protease Inhibitors / Q000097:blood*; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin / Q000097:blood; D000511:alpha-Macroglobulins / Q000097:blood
D006131:Growth Inhibitors; D011480:Protease Inhibitors; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D002918:Chymotrypsin