The chemical basis and specificity of the nitrosonaphthol reaction.
1-Nitroso-2-naphthol reacts with various 5-hydroxyindoles as well as para-substituted phenols and guaiacols. Consequently, this reaction has long been used to measure tyrosine in tyrosinosis and tyrosinemia, homovanillic acid in neuroblastoma, and 5-hydroxy-3-indoleacetic acid in the carcinoid tumor. We report here on the specificity of this reaction, as well as our early observations with respect to the chemical basis of the reaction.
D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism; D002276:Carcinoid Tumor / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D006139:Guaiacol; D006719:Homovanillic Acid / Q000032:analysis*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D007211:Indoles; D009447:Neuroblastoma / Q000378:metabolism; D009603:Nitroso Compounds; D010648:Phenylacetates / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D014439:Tyramine / Q000032:analysis*; D014443:Tyrosine / Q000032:analysis*
D007211:Indoles; D009603:Nitroso Compounds; D010648:Phenylacetates; C026785:5-hydroxyindole; D014443:Tyrosine; D006897:Hydroxyindoleacetic Acid; D006139:Guaiacol; C025341:1-nitroso-2-naphthol; D006719:Homovanillic Acid; D014439:Tyramine