Inhibition of starch absorption by tendamistate (an alpha-amylase inactivator).
Tendamistate (HOE 467) is an alpha-amylase inactivator. Doses of 100 and 200 mg and a placebo were administered to 6 volunteers in order to investigate the effect of the drug on plasma glucose levels after a bread meal. Each subject participated in three phases, in each of which they received a meal consisting of 200 g white bread together with either placebo or tendamistate 100 or 200 mg. Serial blood specimens for plasma glucose determinations were taken up to 3 hours after the meal. Plasma glucose concentrations served as a criterion of starch absorption. Side-effects (flatulence and/or diarrhoea) were reported after each of the three treatments. The administration of tendamistate together with the bread meal resulted in significant inhibition of starch absorption.
D000042:Absorption; D000681:Amylases / Q000037:antagonists & inhibitors*; D001786:Blood Glucose / Q000032:analysis; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D010455:Peptides / Q000494:pharmacology*; D013213:Starch / Q000378:metabolism*; D013997:Time Factors; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D001786:Blood Glucose; D010455:Peptides; D013213:Starch; D000681:Amylases; D000516:alpha-Amylases; C030526:tendamistate