Immunohistochemical localization of pregnancy-associated plasma protein A in decidua and trophoblast: comparison with human chorionic gonadotrophin and fibrin.
In an immunoperoxidase study, pregnancy-associated placental protein A (PAPP-A) was localized to the cytoplasm of decidual stromal cells, the villous syncytiotrophoblast and on the surface of placental trophoblast. A decidual and a trophoblastic origin is suggested for PAPP-A, and its presence on the surface of the syncytiotrophoblast is interpreted as a possible immunoprotective layer.
D006063:Chorionic Gonadotropin / Q000032:analysis*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003656:Decidua / Q000032:analysis*; D005260:Female; D005337:Fibrin / Q000032:analysis*; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D010446:Peptide Fragments / Q000032:analysis; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis*; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D014327:Trophoblasts / Q000032:analysis*
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D011257:Pregnancy Proteins; D005337:Fibrin; D005340:Fibrinogen; D011266:Pregnancy-Associated Plasma Protein-A