title: The source of the dispersity of gramicidin A single-channel conductances. The L X Leu5-gramicidin A analog.
abstract: The L X Leu5-gramicidin A analog has been designed, synthesized, and verified for the purpose of testing the perspective that different side-chain distributions are responsible for the dispersity of single-channel conductances. The structural analysis shows that the L . Leu5 analog would limit the possible number of side-chain distributions and that the dispersity of channel conductances would decrease. The finding is the expected decrease in less probable conductance states and the associated increase in the probability of the most probable conductance state.
mesh_terms: D004553:Electric Conductivity; D006096:Gramicidin / Q000138:chemical synthesis / Q000031:analogs & derivatives; D007473:Ion Channels / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D007473:Ion Channels; D006096:Gramicidin; C042798:gramicidin A, Leu(5)-