The effect of peritoneal lavage and aprotinin in the treatment of severe acute pancreatitis.
Fifty-five patients with severe acute pancreatitis were treated with peritoneal lavage at the Dept. of Surgery at Malmö General Hospital. In a randomized study 26 of the 55 patients received in addition 500,000 KIU aprotinin in the lavage fluid every 2 h. There were no significant differences between the aprotinin- and non-aprotinin-treated groups as to mortality and clinical results. The initial concentration of alpha 1-antitrypsin in plasma was mainly within normal range with increasing values during the treatment. No differences were seen between the two groups. The initial mean level of alpha 2-macroglobulin in plasma was slightly decreased, but 17 patients showed values below normal range. The alpha 2-macroglobulin level during the lavage showed a similar course in the two groups. alpha 1-Antitrypsin and alpha 2-macroglobulin in the lavage fluids showed signs of complexation but in plasma these inhibitors did not show any signs of complexation. On admission to the hospital the mean levels of C3 and kininogen in the plasma were slightly below normal. During the lavage treatment no differences were seen between the two groups. Degradation products of C3 and kininogen were seen in both serum and peritoneal fluids. The electrophoretic patterns of C3 and kininogen normalized in serum as well as in lavage fluids during the lavage treatment without any significant differences in the two groups. High levels of immunoreactive trypsin, pancreatic elastase, PSTI, and leukocyte elastase in serum were seen equally in both groups of patients.
D000208:Acute Disease; D000328:Adult; D007611:Aprotinin / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003176:Complement C3 / Q000378:metabolism; D006801:Humans; D007704:Kininogens / Q000378:metabolism; D008875:Middle Aged; D010195:Pancreatitis / Q000188:drug therapy / Q000628:therapy*; D010529:Peritoneal Cavity; D011897:Random Allocation; D007507:Therapeutic Irrigation; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D003176:Complement C3; D007704:Kininogens; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D007611:Aprotinin