Insulin secretory capacity, beta-thromboglobulin and blood viscosity in long standing, non-insulin dependent diabetics with and without microangiopathy.
A comparison was made of insulin secretion in response to i.v. glucose between noninsulin dependent diabetics with and without severe microangiopathy. During i.v. glucose tolerance testing those with complications had significantly lower serum insulin concentration (at 40 and 60 min 15.2 +/- 2.9 and 11.7 +/- 2.5 mU-1 respectively) than those without (26.1 +/- 4.7 and 24.3 +/- 3.6 mU-1, p less than 0.01). The differences were also significant when insulin increment above basal was determined. All subjects had raised plasma beta-thromboglobulin concentration (indicating increased tendency to platelet aggregation), but with no significant difference between the two groups. There was also no difference in fasting glucose, kg values, HbAl or blood viscosity. We conclude that non-insulin dependent diabetics with severe microangiopathy have significantly reduced insulin secretory capacity in response to i.v. glucose when compared with those without.
D000328:Adult; D000368:Aged; D001609:Beta-Globulins / Q000032:analysis*; D001809:Blood Viscosity / Q000187:drug effects*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D005260:Female; D005947:Glucose / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D001620:beta-Thromboglobulin / Q000032:analysis*
D001609:Beta-Globulins; D007328:Insulin; D001620:beta-Thromboglobulin; D005947:Glucose