title: Pathological fracture, bone metastases and primary hepatocellular carcinoma.
abstract: Pathological fracture and metastatic bone disease without pulmonary metastases were the presenting features in three patients ultimately found to have primary hepatocellular carcinoma. In one case immunoperoxidase staining of bone scrapings for alpha-fetoprotein secreting cells contributed directly to the diagnosis.
mesh_terms: D001859:Bone Neoplasms / Q000150:complications / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology / Q000556:secondary*; D005260:Female; D005264:Femoral Fractures / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins