A rat yolk-sac antigen defined by monoclonal antibodies.
The distribution of a rat yolk-sac antigen (Rat YSA-I) as defined by a monoclonal antibody raised against rat yolk-sac carcinoma cells is described. The antigen is present on rat yolk-sac carcinomas, on visceral yolk-sac endoderm and on embryonal endoderm of 9-day-old embryos. It is not present on a variety of rat tumors other than yolk-sac carcinomas and not detectable on pre-implantation embryos, inner cell mass and fetal endoderm. Rat YSA-I differs from alpha-fetoprotein and Forssman antigen and is species-specific. In adult rats the only cells displaying this antigen are the spermatozoa and certain cells of the spermatogenic lineage.
D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D001755:Blastocyst / Q000276:immunology*; D002460:Cell Line; D005260:Female; D005326:Fetal Proteins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D005577:Forssman Antigen / Q000032:analysis; D008649:Mesonephroma / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000276:immunology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D015017:Yolk Sac / Q000276:immunology*; D000509:alpha-Fetoproteins / Q000032:analysis
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D005326:Fetal Proteins; D000509:alpha-Fetoproteins; D005577:Forssman Antigen