Effect of clenbuterol, a new beta 2 selective adrenoceptor stimulant, on the release of histamine and SRS-A from passively sensitized guinea-pig chopped lungs.
Effect of clenbuterol on the release of histamine and SRS-A from passively sensitized guinea-pig lungs was studied in a superfused-cascade bioassay system, and compared with isoproterenol and salbutamol. One-week-old guinea-pig lungs were used, since histamine and SRS-A were released more in these than in 6- or 12-week old lungs during anaphylaxis. Clenbuterol, isoproterenol and salbutamol (10(-8) - 10(-7) M) were found to inhibit the releases of histamine and SRS-A. These actions were inhibited by propranolol. These results suggest that clenbuterol inhibits the releases of histamine and SRS-A via the beta-adrenoceptor.
D000375:Aging; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D002867:Chromones / Q000494:pharmacology; D002976:Clenbuterol / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000187:drug effects* / Q000276:immunology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000378:metabolism*
D002867:Chromones; D004983:Ethanolamines; D013189:SRS-A; C006312:FPL 55712; D011433:Propranolol; D007545:Isoproterenol; D000420:Albuterol; D002976:Clenbuterol