title: Quinine and quinidine: a comparison of EKG effects during the treatment of malaria.
abstract: We recorded electrocardiograms from 31 patients receiving quinine and 14 patients receiving quinidine for the treatment of Plasmodium falciparum malaria. Despite plasma quinine concentrations of up to 20 mg/L, there was no evidence of cardiotoxicity. QT prolongation was considerably greater in the quinidine-treated patients. The mean ratio of change in corrected QT interval to change in plasma concentration (delta QTc%/delta CQ) was 3.2% . mg-1 . L-1 for quinidine, compared to 0.74% . mg-1 . L-1 for quinine (p less than 0.001). T-wave flattening was observed in both groups. Plasma concentrations of quinine cannot be predicted from the EKG, because concentrations within the therapeutic range produced only minor and unpredictable abnormalities.
mesh_terms: D000328:Adult; D004562:Electrocardiography; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000503:physiopathology; D011802:Quinidine / Q000009:adverse effects* / Q000097:blood; D011803:Quinine / Q000009:adverse effects* / Q000097:blood
chemical_list: D011803:Quinine; D011802:Quinidine