The effect of in vivo exposure to diesel exhaust on rat hepatic and pulmonary microsomal activities.
The effect of exposure to three concentrations of diesel exhaust on several heptic and pulmonary activities has been tested. After one year of exposure, the ability of liver microsomes to oxidize benzo[alpha]pyrene to more polar metabolites was not increased. Further studies with liver microsomes showed that, after several months of exposure, there was no evidence for the induction of either cytochrome P-450, cytochrome P-448 or NADPH dependent cytochrome c reductase. The ability of pulmonary microsomes to generate polar metabolites from benzo[alpha]pyrene was impaired after one year of exposure to the highest concentration of exhaust (1500 micrograms m-3). The process by which the exposure causes this inhibition is not clear.
D000336:Aerosols; D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism; D002273:Carcinogens / Q000378:metabolism; D005648:Fuel Oils / Q000633:toxicity*; D008168:Lung / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010578:Petroleum / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D001335:Vehicle Emissions / Q000633:toxicity*
D000336:Aerosols; D000393:Air Pollutants; D001580:Benzopyrenes; D002273:Carcinogens; D005648:Fuel Oils; D010578:Petroleum; D001335:Vehicle Emissions; D001564:Benzo(a)pyrene