Preferential inhibition of ribonucleic acid synthesis by a new thiosemicarbazone possessing antibacterial and antiparasitic properties.
We determined the influence of the azacycloheptane derivative (H) of a 2-acetylpyridine thiosemicarbazone on growth and macromolecular synthesis in Escherichia coli AT-9. Thiosemicarbazone H caused bacteriostasis and a primary inhibition of ribonucleic acid synthesis; secondary effects included inhibition of deoxyribonucleic acid and protein synthesis. Addition of cooper or other transition elements was not necessary for these inhibitions.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis; D004269:DNA, Bacterial / Q000096:biosynthesis; D003839:Deoxyadenosines / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis*; D013882:Thiosemicarbazones / Q000494:pharmacology*; D014498:Uracil / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D003839:Deoxyadenosines; D012329:RNA, Bacterial; D013882:Thiosemicarbazones; D010649:Phenylalanine; D014498:Uracil; C035532:thiosemicarbazone H