Effects of bromocriptine on plasma testosterone and gonadotropin levels and testicular lipid fractions in adult rats.
Bromocriptine treatment of adult male rats resulted in a decrease in testicular testosterone (T) content and a reduction in plasma T levels. This was accompanied by increase in testicular total lipids and cholesterol and depletion of testicular phospholipids.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000097:blood*; D050356:Lipid Metabolism; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000097:blood / Q000378:metabolism*
D006065:Gonadotropins, Pituitary; D010446:Peptide Fragments; D010743:Phospholipids; D013373:Substance P; D001971:Bromocriptine; D013739:Testosterone; C040436:substance P (4-11), Pro(4)-Trp(7,9,10)-; C040435:substance P (4-11), Pro(4)-Val(8)-Trp(7,9,10)-; D011388:Prolactin; D002784:Cholesterol