title: An X-linked locus influences the amount of circulating interferon induced in the mouse by herpes simplex virus type 1.
abstract: Production of circulating interferon (IFN) was measured in inbred mouse strains following intravenous injection of herpes simplex virus type 1 (HSV-1). IFN titres reached maximal levels 2 to 3 h after injection of virus and a 10-fold difference was found between C57BL/6 mice and BALB/c, as high and low producers respectively. Mendelian analysis revealed that HSV-induced IFN production is governed by several loci, one of which is X-linked. The strain distribution pattern obtained from results in recombinant inbred lines and the results obtained in the congenic B6-C-H-28c-If-1(1) strain furthermore indicated an absence of close linkage to If-1. It is concluded that the levels of HSV-induced early IFN production are influenced by several autosomal loci and one X-linked locus.
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D007372:Interferons / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011995:Recombination, Genetic; D012730:Sex Chromosomes; D018139:Simplexvirus / Q000502:physiology*; D013045:Species Specificity; D014960:X Chromosome
chemical_list: D007372:Interferons