title: Selective emigration of suppressor T cells from Peyer's patches.
abstract: The emigration of Peyer's patch lymphocytes to mesenteric lymph nodes was studied by injecting fluorescein isothiocyanate (FITC) directly into Peyer's patches. Using double immunofluorescence it was demonstrated that at 2 and 4 hr after FITC injection 70% of the labeled cells that migrated to mesenteric lymph nodes were T lymphocytes, although rat Peyer's patches contain only 15-20% T lymphocytes. At later time points after FITC injection this percentage of T cells derived from Peyer's patches gradually declined, most likely caused by selective interaction and/or retention inside the mesenteric lymph node. Determination of helper and suppressor T-cell subsets within this emigrating population showed an increased number of T suppressor cells migrating into mesenteric lymph nodes. The putative role of suppressor T cells in inducing systemic tolerance after oral antigen administration was discussed.
mesh_terms: D000818:Animals; D002465:Cell Movement; D016650:Fluorescein-5-isothiocyanate; D005452:Fluoresceins / Q000494:pharmacology; D008198:Lymph Nodes / Q000166:cytology*; D008221:Lymphoid Tissue / Q000166:cytology*; D008297:Male; D008643:Mesentery; D010581:Peyer's Patches / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013861:Thiocyanates / Q000494:pharmacology
chemical_list: D005452:Fluoresceins; D013861:Thiocyanates; D016650:Fluorescein-5-isothiocyanate