Monocyte Fc-IgG receptors expression and soluble suppressor factor in skin squamous cell carcinoma.
The expression of Fc-IgG receptors on mononuclear phagocytes (monocytes/macrophages), as well as the activity of soluble immune suppressor supernatant of T-cell proliferation (SISS-T) factor have been investigated in 23 patients with squamous cell carcinoma (SCC) of the lower lip, including 8 patients with metastases in the regional lymph glands. The results demonstrated a significant increase of the expression of Fc-IgG receptors only on circulating monocytes of patients with metastatic SCC. The suppressor function evaluated by means of the SISS-T factor proved normal in patients with nonmetastatic skin SCC and reduced in 8 patients with metastatic SCC.
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008048:Lip Neoplasms / Q000276:immunology*; D008207:Lymphatic Metastasis; D008222:Lymphokines / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D011506:Proteins / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology*; D012995:Solubility; D013491:Suppressor Factors, Immunologic
D008222:Lymphokines; D011506:Proteins; D011961:Receptors, Fc; D013491:Suppressor Factors, Immunologic