[How dangerous is the dipyridamole test?].
In 203 patients with clinical symptoms of coronary artery disease, cardiac and extracardiac side effects of the dipyridamole test were investigated. Following dipyridamole (0.75 mg/kg body wt. i.v.), heart rate increased significantly, whereas arterial blood pressure remained almost constant. Dyspnea was noted in 80 cases (40.5%). In 48 patients (23.6%) rhythm disturbances were recorded; 58.1% suffered from extracardiac side effects such as congestion in the head, vertigo, heaviness of arms and legs, sensations of heat, upper abdominal pain, and nausea. A detailed report is given of 4 cases with extraordinary symptoms during or after the injection of dipyridamole. A life-threatening status anginosus with dyspnea, ST-segment elevation, and cardiac arrhythmia was observed in one of these cases. High-dose dipyridamole cannot be considered to be harmless. The test should not be performed without continuous ECG monitoring and other safety measures.
D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000627:therapeutic use; D000787:Angina Pectoris / Q000139:chemically induced / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D005117:Cardiac Complexes, Premature / Q000139:chemically induced; D003327:Coronary Disease / Q000175:diagnosis*; D004176:Dipyridamole / Q000009:adverse effects*; D004417:Dyspnea / Q000139:chemically induced; D004562:Electrocardiography; D005260:Female; D006261:Headache / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
D000628:Aminophylline; D004176:Dipyridamole
Wie gefährlich ist der Dipyridamoltest?