Alpha feta (alpha FP) monitoring of response to adriamycin in hepatoblastoma.
While emphasizing the potential of chemotherapy (particularly adriamycin) in the treatment of hepatoblastoma, Andrassy et al., omit mention of the importance of serial serum alpha FP measurements in determining response and in early detection of recurrence. Serum alpha FP was elevated (range 5,000-1,800,000 micrograms/l) in 10 of 11 children with hepatoblastoma seen at our hospital between 1970 and 1980 and is, as others have emphasized, a potentially useful "marker" for this tumor. We report here the details of one patient in whom alpha FP monitoring was crucial to early detection of pulmonary metastases; complete response to adriamycin was subsequently documented.
D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000601:surgery; D002675:Child, Preschool; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins; D004317:Doxorubicin