Pharmacology of an emulsion formulation of ICI 35 868.
Studies with an emulsion formulation of ICI 35 868 (2,6- diisopropylphenol ) indicate that this new formulation has anaesthetic properties in rats and mice, and haemodynamic effects in the mini-pig which are similar to those of the previously available Cremophor formulation. Administration of the emulsion formulation to dogs produced no untoward effect, whereas the Cremophor formulation produced a marked increase in plasma histamine concentration. In the mini-pig, no adverse response was produced by the repeated administration of the emulsion formulation of ICI 35 868, whereas the Cremophor formulation produced anaphylactoid responses when a second injection was given 1 week after an uneventful first exposure to this formulation. Behavioural responses in the rat suggest that the emulsion formulation may produce less discomfort on i.v. injection.
D000707:Anaphylaxis / Q000139:chemically induced; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D004285:Dogs; D004655:Emulsions; D005260:Female; D005990:Glycerol / Q000031:analogs & derivatives / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D015742:Propofol; D051381:Rats; D012997:Solvents / Q000494:pharmacology; D013552:Swine; D013997:Time Factors
D000777:Anesthetics; D004655:Emulsions; D010636:Phenols; D012997:Solvents; C000515:cremophor EL; D005990:Glycerol; D015742:Propofol