Distribution of rabies virus, interferon and interferon-mediated enzymes in the brains of virus-infected rats.
The distribution of rabies virus, interferon and interferon-mediated enzymes, pppA(2'p5'A)n synthetase (2-5A synthetase) and poly(rI) . poly(rC)-Sepharose-bound protein kinase, was studied in different regions of the brains of rabies virus-infected rats. A broad range of virus infectivity was found in the brain stem, cerebellum, cortex, hippocampus and striatum. Similarly, the levels of interferon were variable (2500 to 60 000 units/mg protein in tissue extracts) in the different brain regions studied but were unrelated to the corresponding infectivities . The level of 2-5A synthetase and protein kinase was enhanced several-fold in the individual brain regions and the degree of such enhancement was correlated with the level of interferon.
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000382:microbiology*; D001931:Brain Mapping; D007372:Interferons / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D010750:Phosphoproteins / Q000032:analysis; D011818:Rabies / Q000276:immunology / Q000382:microbiology*; D051381:Rats
D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase