Factors influencing human leukocyte adherence in vivo.
The effects of different factors on leukocyte adherence was evaluated by using human peripheral blood before and after treatment (application). Magnesium ions, anti-inflammatory drugs and dextran have decreased neutrophil adherence. Calcium ions, propranolol, blood transfusion caused a significant decrease in adherence. These findings support the conclusion that the adherence test, which is influenced by numerous factors and whose results had a wide scatter, is not a useful tool in clinical diagnosis.
D000328:Adult; D000628:Aminophylline / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002125:Calcium Gluconate / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects*; D003872:Dermatitis / Q000097:blood*; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D007962:Leukocytes / Q000166:cytology* / Q000187:drug effects; D008278:Magnesium Sulfate / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D000628:Aminophylline; D008278:Magnesium Sulfate; D011433:Propranolol; D005947:Glucose; D002125:Calcium Gluconate