Endogenous myelin basic protein-serum factors (MBP-SFS) and anti-MBP antibodies in a patient with post-herpes simplex virus acute disseminated encephalomyelitis.
The measurement of myelin basic protein serum factors (MBP-SFs) and anti-MBP antibodies in specimens from a patient with post-herpes simplex acute disseminated encephalomyelitis (ADE) is described. Transitory appearance of high affinity anti-MBP antibodies in the absence of detectable MBP-SFs was observed. This pattern was similar to that found previously in acute multiple sclerosis and experimental allergic encephalomyelitis. These findings are consistent with the hypothesis that a possible normal role of MBP-SFs is as neuroautotolerogens, preventing autoreactive lymphocyte clones from damaging myelin.
D000208:Acute Disease; D000328:Adult; D000906:Antibodies / Q000032:analysis* / Q000134:cerebrospinal fluid; D000915:Antibody Affinity; D001798:Blood Proteins / Q000134:cerebrospinal fluid; D004679:Encephalomyelitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology / Q000276:immunology*; D006561:Herpes Simplex / Q000150:complications*; D006801:Humans; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology*; D011863:Radioimmunoassay
D000906:Antibodies; D001798:Blood Proteins; D004676:Myelin Basic Protein; C032632:myelin basic protein-serum factors