The occurrence of marker cells in fetal hematopoiesis of beige (Chédiak-Higashi) mouse.
The presence of neutrophils and their precursors with peroxidase-positive and sudanophilic giant granules, which are characteristic of Chédiak-Higashi syndrome (CHS), in the fetal liver and blood of beige (CH), but not of the control C 57 Black, mice was observed. This finding supports the view that the prenatal diagnosis could be possible, if the fetal blood specimen is obtainable safely, assuming the occurrence of similar marker cells in fetal hematopoiesis in CHS of human.
D000818:Animals; D001391:Azo Compounds; D002609:Chediak-Higashi Syndrome / Q000196:embryology* / Q000473:pathology; D003594:Cytoplasmic Granules / Q000473:pathology*; D005312:Fetal Blood / Q000166:cytology*; D006410:Hematopoiesis; D008099:Liver / Q000166:cytology* / Q000196:embryology; D051379:Mice; D008810:Mice, Inbred C57BL; D009281:Naphthalenes; D009504:Neutrophils / Q000648:ultrastructure*; D010544:Peroxidases; D013194:Staining and Labeling
D001391:Azo Compounds; D009281:Naphthalenes; C016118:Sudan Black B; D010544:Peroxidases