Combined treatment of coenzyme Q10 and aprotinin with intraaortic balloon pumping following aorto-coronary bypass surgery.
The effect of combined treatment of coenzyme Q10 (CoQ10) and aprotinin with intra-aortic balloon pumping (IABP) was evaluated in patients who underwent aorto-coronary bypass surgery. Forty-one patients were divided into two groups. Group A (27) were treated by IABP only and Group B (14) were treated by the concomitant use of CoQ10 and aprotinin with IABP. Both groups were subdivided into two groups with regard to the ability to be weaned from IABP (Group A-I, Group B-I) or the inability (Group A-II, Group B-II). CoQ10 was administrated intravenously at doses of 5-10 mg/kg/day and aprotinin was infused at doses 5,000-10,000 KU/kg/day. The percentile incidence of ability to be weaned from IABP was 93 per cent (13/14) in Group B was higher than that of 74 per cent (20/27) in Group A. There were no significant differences among Group A-I, Group A-II, and Group B-I with regard to preoperative and intraoperative factors. Serum GOT and CPK levels on the first postoperative day were significantly higher in Group A-II and Group B-I than those in Group A-I but there was no significant difference between GOT or CPK levels in Group A-II and Group B-I. These results suggest that concomitant treatment of CoQ10 and aprotinin with IABP leads to an improvement in postoperative low cardiac output syndrome.
D007611:Aprotinin / Q000008:administration & dosage*; D001219:Aspartate Aminotransferases / Q000097:blood; D001243:Assisted Circulation; D002303:Cardiac Output, Low / Q000628:therapy; D003067:Coenzymes; D001026:Coronary Artery Bypass; D003402:Creatine Kinase / Q000097:blood; D004359:Drug Therapy, Combination; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007423:Intra-Aortic Balloon Pumping; D007527:Isoenzymes; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
D003067:Coenzymes; D007527:Isoenzymes; D014451:Ubiquinone; D007611:Aprotinin; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; C024989:coenzyme Q10