title: Interferon with novel characteristics produced by human mononuclear leukocytes.
abstract: Treatment of human peripheral blood mononuclear leukocytes with phytohaemmaglutinin and the tumour promoter teleocidin, results in the production of large amounts of interferon-gamma and significant amounts of a novel interferon-like substance which we tentatively class as interferon-delta. This novel interferon type possesses all the important characteristics of classical interferon but, of various cell types tested, has antiviral activity only in trisomy-21 human fibroblasts. It differs decisively from previously identified interferon types in its antigenic, biological and physicochemical properties.
mesh_terms: D000818:Animals; D002417:Cattle; D002460:Cell Line; D002846:Chromatography, Affinity; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007370:Interferon Type I / Q000097:blood*; D051379:Mice; D008970:Molecular Weight; D009000:Monocytes / Q000032:analysis*
chemical_list: D000939:Epitopes; D007370:Interferon Type I; C037655:interferon, delta