[Microanalysis in oncological diagnosis].
An analysis of the diagnosis accuracy of malignant gastric, rectal, liver and prostatic tumors was performed with relation to the sensitivity and specificity of radioimmunological and immunoenzyme commercial kits of reagents manufactured by different companies and used to determine the concentration of the carcinoembryonic antigen, alpha-fetoprotein and acid phosphatase of the prostate. With an increase of the test specificity its diagnostic sensitivity decreases, i.e. the percentage of false-negative results increases. The use of highly specific monoclonal antibodies in serological tests results in a marked decrease of the accuracy of tumor diagnosis. The author thinks it necessary to strictly determine indications for the use of the serological and immunodiagnostic kits: for the identification of risk populations, early diagnosis of tumors, differential diagnosis or the monitoring of patients.
D000135:Acid Phosphatase / Q000097:blood; D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009369:Neoplasms / Q000175:diagnosis*; D011467:Prostate / Q000201:enzymology; D011863:Radioimmunoassay / Q000379:methods; D000509:alpha-Fetoproteins / Q000032:analysis
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins; D000135:Acid Phosphatase
Mikroanaliz v onkologicheskoĭ diagnostike.