Changes in hepatic levels of tyrosine aminotransferase messenger RNA during chemical hepatocarcinogenesis.
The activity of tyrosine aminotransferase (TAT) decreased biphasically in livers of rats fed 3'-methyl-4-dimethylaminoazobenzene (3'-MDAB). TAT activity decreased to an extremely low level at later stages of hepatocarcinogenesis. The activity of TAT is negatively correlated with alpha-fetoprotein (AFP) levels. The level of TAT enzyme activity in precancerous liver and hepatoma is a reflection of the amount of TAT mRNA. Dexamethasone increased the TAT enzyme activity and TAT mRNA concentration in rat livers during chemical carcinogenesis.
D000818:Animals; D003907:Dexamethasone / Q000378:metabolism; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000302:isolation & purification; D011230:Precancerous Conditions / Q000139:chemically induced / Q000235:genetics*; D012333:RNA, Messenger / Q000302:isolation & purification*; D051381:Rats; D012709:Serum Albumin / Q000235:genetics; D014444:Tyrosine Transaminase / Q000235:genetics*; D000509:alpha-Fetoproteins / Q000235:genetics; D004124:p-Dimethylaminoazobenzene
D012333:RNA, Messenger; D012709:Serum Albumin; D000509:alpha-Fetoproteins; D011061:Poly A; D003907:Dexamethasone; D004124:p-Dimethylaminoazobenzene; D014444:Tyrosine Transaminase