title: [Human transfer factor. I. Production by the great pool technic and the biochemical and immunological characteristics of the preparation].
abstract: A great pool procedure for producing human transfer factor preparations from buffy-coats of stored whole blood which has not been used up till now is described. From an initial tool size of about 1,500 units of whole blood the procedure represented makes it possible to gain higher amounts of uniform and in their immunological efficacy in vitro standardizable preparations for controlled long-term therapy studies. By means of various immunological in vitro tests, stimulating as well as suppressing activities of the charges obtained could be identified. Starting from the differentiated immunological effects of various charges of the transfer factor on T-cell populations in vitro, the possibility of influencing T-cell subpopulations through well-conceived therapeutic measures by a transfer factor is discussed.
mesh_terms: D000328:Adult; D002464:Cell Migration Inhibition; D005612:Freeze Drying; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D008851:Micropore Filters; D010455:Peptides / Q000032:analysis; D012266:Ribose / Q000032:analysis; D012397:Rosette Formation; D014165:Transfer Factor / Q000032:analysis / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D010455:Peptides; D014165:Transfer Factor; D012266:Ribose
vernacular_title: Humaner Transfer-Faktor. I. Herstellung nach einem Grosspoolverfahren sowie biochemische und immunologische Charakterisierung des Präparates.