title: Effect of human lymphoblastoid interferon on human yolk sac tumors in nude mice.
abstract: The effect of human lymphoblastoid interferon on the growth of human tumors heterotransplanted into nude mice was examined. The human tumor lines examined, named YST-1, YST-2 and YST-3, were derived from yolk sac tumors of the ovary. Daily intraperioneal injection of 3 X 10(4) U interferon per mouse for 14 days did not inhibit the growth of any of these three human tumor lines. A close correlation was observed between the tumor volume and the level of alpha-fetoprotein in sera of mice bearing the YST-1 tumor (r = 0.55) or YST-2 tumor (r = 0.70). No histological differences were detected between tumor cells of interferon-treated and control mice. Tumor-bearing mice treated with interferon showed no marked weight loss.
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008649:Mesonephroma / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D007370:Interferon Type I; D000509:alpha-Fetoproteins