Promotion of Pasteurella haemolytica infection in mice by iron.
Mice given 60 micrograms iron, as aqueous ferric ammonium citrate, intravenously were more susceptible than untreated controls to intraperitoneal infection with T serotypes of Pasteurella haemolytica as shown by significant reductions in LD50 values. Iron injection has advantages over administration of bacteria suspended in mucin for studies of P haemolytica infection in mice.
D000818:Animals; D004198:Disease Susceptibility; D005290:Ferric Compounds / Q000494:pharmacology*; D005752:Gastric Mucins / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D010325:Pasteurella / Q000187:drug effects* / Q000472:pathogenicity; D010326:Pasteurella Infections / Q000401:mortality*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014774:Virulence / Q000187:drug effects
D005290:Ferric Compounds; D005752:Gastric Mucins; D000644:Quaternary Ammonium Compounds; D007501:Iron; C013531:ferric ammonium citrate