Sensitized spleen B-cells in tolerance-resisting SJL mice.
A subpopulation of B-cells becomes sensitized in the 15-week-old SJL mouse, exposed to aggregate-freed rabbit gamma-globulin, which is highly tolerogenic when given to younger animals. This state of activation can only be expressed in collaboration with sensitized T-cells. The sensitized B-cell does not play an important role in the response of the intact 15-week-old SJL mouse, since there are no sensitized T-cells in the sRGG-treated animals.
D000375:Aging; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D006801:Humans; D007108:Immune Tolerance; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010047:Ovalbumin / Q000276:immunology; D011817:Rabbits; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D005719:gamma-Globulins / Q000008:administration & dosage / Q000276:immunology
D004136:Dinitrobenzenes; D005719:gamma-Globulins; D010047:Ovalbumin