Exchangeable sodium in renal hypertension in the rat.
Rats with two-kidney, one-clip hypertension (2K1C) have a marked rise in plasma renin activity (PRA) and, when drinking 0.9% NaCl as their sole source of sodium, have increased exchangeable and total body sodium levels. These changes are reversed by the administration of captopril. The one-kidney, one-clip (1K1C) model has no rise in PRA or increase in body sodium level after either an early or a late contralateral nephrectomy. The data indicate that hypertension in the 2K1C model is due to the high angiotensin levels in these animals. Activation of the renin-angiotensin system requires the presence of the contralateral kidney but is not the result of sodium loss from that kidney. The reason for activation of the renin-angiotensin system in the 2K1C hypertensive rat remains obscure.
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D006977:Hypertension, Renal / Q000378:metabolism*; D007668:Kidney / Q000502:physiology; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism*
D002216:Captopril; D012964:Sodium; D012083:Renin