Uptake of labelled tallysomycin by solid Ehrlich ascites tumors in mice.
Tumor and normal tissue uptake of 51Cr- or 57Co-labelled bleomycin (BLEO) and tallysomycin (TLM) was compared in female solid Ehrlich ascites tumor mice of Swiss strain. The complexes were administered intraperitoneally: 30-50 micrograms of each complex with an activity of 40-120 microCi. Activity distribution factors (ADF) and tumor/non-tumor ratios for blood, bone, skeletal muscles, kidneys and liver were determined. The ratios were generally higher for complexes labelled with 57Co than for the 51Cr-labelled ones; bleomycin appears equivalent or superior to tallysomycin.
D000818:Animals; D001761:Bleomycin / Q000097:blood / Q000378:metabolism* / Q000031:analogs & derivatives; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002860:Chromium Radioisotopes; D003037:Cobalt Radioisotopes; D005260:Female; D051379:Mice; D009368:Neoplasm Transplantation; D014018:Tissue Distribution
D002860:Chromium Radioisotopes; D003037:Cobalt Radioisotopes; D001761:Bleomycin; C016126:talisomycin