Effect of adrenalectomy on chlordecone potentiation of carbontetrachloride hepatotoxicity.
The propensity of chlordecone (CD) to potentiate CCl4 hepatotoxicity in rats of either sex has been well documented. The objective of the present study was to investigate the hepatotoxic effects of CD-CCl4 interaction in adrenalectomized rats. Adrenalectomized rats were maintained on 0 or 10 ppm CD and on day 15 they received a single ip injection of 25 microL CCl4/kg. Hepatotoxicity was assessed by hepatofunctional, biochemical and histopathological parameters, 24 hrs after CCl4 challenge. CCl4-induced hepatobiliary dysfunction and elevation of serum enzymes (GPT, GOT, ICD and OCT) were evident. Hepatic dysfunction was most severe in adrenalectomized rats receiving CD-CCl4 combination treatment. Histopathology of liver exhibited extensive fatty infiltration in the entire lobular structure accompanied by some necrosis. These data indicate that the capacity of CD to potentiate CCl4 hepatotoxicity is unaffected in adrenalectomized rats.
D000315:Adrenalectomy; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D007631:Chlordecone / Q000633:toxicity*; D004357:Drug Synergism; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; D002251:Carbon Tetrachloride; D007631:Chlordecone