Thermal enhancement of bleomycin-induced tumour growth delay: the effect of dose fractionation.
The influence of hyperthermia on bleomycin-induced growth delay of a syngeneic murine carcinoma has been studied in both simultaneous and sequential schedules for single and multi-fraction drug dose. The results reveal thermal potentiation of drug-induced growth delay if treatment is given simultaneously. This observed potentiation is independent of single or multi-fraction drug administration. Sequential pre-heating treatment resulted in only additive growth rate depression for single and two-fraction drug doses. However, when the drug dose was given in three fractions a significant thermal potentiation was observed for both simultaneous and sequential schedules.
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D006979:Hyperthermia, Induced; D051379:Mice; D008808:Mice, Inbred CBA
D001761:Bleomycin