Colchicine injection in the inferior olivary nucleus increases the number of Purkinje cell dendritic spines.
The number of Purkinje cell dendritic spines was evaluated in the cerebellum of rats after injection of colchicine into the inferior olivary nucleus. In these conditions, the spines situated in the proximal (inner) part of the molecular layer were increased as compared to lumicolchicine-injected or non-injected control animals. Most postsynaptic targets for climbing fibers are located in the inner molecular layer and the fact that spines in this region increased when axonal transport was blocked in the climbing fibers suggests that the latter play a role in the control of spine formation.
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D003712:Dendrites / Q000187:drug effects* / Q000502:physiology; D008162:Lumicolchicines / Q000494:pharmacology; D008297:Male; D009847:Olivary Nucleus / Q000187:drug effects; D011689:Purkinje Cells / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D008162:Lumicolchicines; D003078:Colchicine