Effect of intravenous aprotinin (Trasylol) on the healing of experimental colonic anastomoses in the rabbit.
A randomized controlled trial to assess the effect of intravenously administered Trasylol on the healing of experimental colonic anastomoses in the rabbit has been performed. Before undergoing a standard left colonic resection and anastomosis, the animals received intravenous Trasylol (80,000 KIU). Postoperatively 160,000 KIU were given in divided doses per day for 3 days. Control animals received saline placebo. The mean bursting pressure of the anastomoses in the Trasylol-treated group was 47.7 +/- 3.0 mm Hg compared with 37.5 +/- 3.3 mm Hg for the control group (p less than 0.05). The mean difference in collagen content of the anastomosis compared to the resected specimen was +1.25 +/- 0.50 micrograms/mg and -1.02 +/- 0.47 microgram/mg for Trasylol and placebo, respectively (p less than 0.005). In this model intravenous Trasylol produces a significant elevation of the bursting pressure and a significant improvement in the collagen content of the anastomosis. This may be the result of collagenase inhibition.
D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen / Q000032:analysis; D003106:Colon / Q000503:physiopathology / Q000601:surgery*; D007275:Injections, Intravenous; D008297:Male; D011312:Pressure; D011817:Rabbits; D011897:Random Allocation; D014945:Wound Healing / Q000187:drug effects*
D003094:Collagen; D007611:Aprotinin