Haptoglobin and lipoperoxides in rabbit plasma under turpentine- and endotoxin-induced inflammation.
Inflammation was induced in rabbits by injection of turpentine or/and endotoxin. Haptoglobin (Hp) and lipoperoxide (as malondialdehyde - MDA) concentrations in rabbit plasma, were measured. In some experiments indomethacin was administered, as a specific control of anti-inflammatory action. In the course of the reagents-induced inflammation there existed positive correlation between changes in Hp and MDA levels. Indomethacin was found to eliminate this effect. Under the model system of experiments, Hp as presumed endogenous inhibitor of prostaglandin synthesis, even in concentrations in rabbits' blood 15-20 times higher than normal, did not exert any protective action against inflammation.
D000818:Animals; D004347:Drug Interactions; D004731:Endotoxins; D005260:Female; D006242:Haptoglobins / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D011817:Rabbits; D014425:Turpentine
D004731:Endotoxins; D006242:Haptoglobins; D008054:Lipid Peroxides; D008315:Malondialdehyde; D014425:Turpentine; D007213:Indomethacin