HLA -A, -B, -C and -DR antigens in individuals with sensitivity to cobalt.
In a skin investigation of 853 individuals working with hard metal manufacturing 39 cases of cobalt allergy were found. Thirty-five of the individuals with cobalt sensitivity and 102 matched controls were HLA-A, -B, -C and -DR typed. No significantly deviating HLA antigen frequencies were observed when the two groups were compared. Thus, there are no signs that a certain HLA antigen would dispose to cobalt allergy. In the cobalt sensitive group the B7 positive individuals showed particularly often simultaneous reactions to other contact allergens (p = less than 0.025). The B12 positive individuals had low reactivity (p = less than 0.0001) while the A28 positive showed high reactivity (p = less than 0.015).
D003035:Cobalt / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000276:immunology*; D009783:Dermatitis, Occupational / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007221:Industry; D008297:Male; D008670:Metals; D013223:Statistics as Topic
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D008670:Metals; D003035:Cobalt