Class 1 major histocompatibility complex antigens on human extra-villous trophoblast.
Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all forms of villous trophoblast. The extra-villous trophoblast which reacted with antibodies to monomorphic class 1 MHC antigens consistently failed to bind HLA-A or HLA-B antibodies specific for the foetal phenotype. This suggests, but does not prove, that the MHC antigen expression of trophoblast may be restricted to HLA-C or some other undefined class 1 antigen.
D000918:Antibody Specificity; D002823:Chorion / Q000276:immunology; D000939:Epitopes / Q000032:analysis; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D007124:Immunoenzyme Techniques; D008285:Major Histocompatibility Complex; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology
D000939:Epitopes; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D001613:beta 2-Microglobulin