title: Monoclonal antibodies inhibiting RNA polymerase from Escherichia coli.
abstract: Monoclonal hybridoma antibodies directed against RNA polymerase from E. coli have been obtained. Only a few have been found to inhibit the enzyme activity. Antibodies produced by two clones, PYN-1 and PYN-2, inhibit RNA polymerase at the stage of RNA chain elongation. The PYN-1 antibodies react with the beta'-subunit of the enzyme. The PYN-2 antibodies react with the beta-subunit and with its 130 kDa amber fragment.
mesh_terms: D000911:Antibodies, Monoclonal; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000276:immunology*; D000939:Epitopes; D004926:Escherichia coli / Q000201:enzymology*; D007120:Immunochemistry; D011863:Radioimmunoassay
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D012321:DNA-Directed RNA Polymerases