title: Inhibition of human tissue kallikrein by alpha 1-proteinase inhibitor.
abstract: Tissue kallikreins, human urinary and pancreatic kallikrein, were inhibited by alpha 1-proteinase inhibitor, but the other inhibitors in plasma could not inhibit kallikrein activity towards a synthetic substrate. The kallikrein-inhibitor complex was identified by Sephadex G-150 gel filtration. The inhibition rate of urinary kallikrein by alpha 1-proteinase inhibitor was smaller than that of pancreatic kallikrein, and a less acidic subform of kallikrein was inhibited more rapidly than the more acidic one. Moreover, asialo-kallikrein was inhibited more rapidly than native kallikrein.
mesh_terms: D001798:Blood Proteins / Q000502:physiology*; D002241:Carbohydrates / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D006868:Hydrolysis; D007124:Immunoenzyme Techniques; D007525:Isoelectric Focusing; D007610:Kallikreins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008970:Molecular Weight; D009439:Neuraminidase; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins / Q000302:isolation & purification
chemical_list: D001798:Blood Proteins; D002241:Carbohydrates; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D009439:Neuraminidase; D007610:Kallikreins