Thyroxine preferentially stimulates transcription by isolated neuronal nuclei in the developing rat brain cortex.
The administration of thyroxine to neonatal rats stimulates RNA synthesis by neuronal nuclei isolated from the developing rat brain cortex. Glial nuclei are relatively resistant to thyroxine treatment. The activity of neuronal RNA polymerase II is particularly stimulated by the hormone. Thyroxine also affects neuronal chromatin structure as shown by changes in the relative proportion of different subnuclear fractions obtained by gentle micrococcal nuclease digestion of nuclei from hormone-treated rats.
D000546:Amanitins / Q000494:pharmacology; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002540:Cerebral Cortex / Q000254:growth & development*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011072:Poly U / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*; D014542:Uridine Monophosphate / Q000378:metabolism; D014544:Uridine Triphosphate / Q000378:metabolism
D000546:Amanitins; D011072:Poly U; D012313:RNA; D014542:Uridine Monophosphate; D013974:Thyroxine; D014544:Uridine Triphosphate