[Effect of kallikrein and its inhibitor on absorption from the abdominal cavity in peritonitis].
Experiments were carried out in 195 albino rats. It was established that in acute peritonitis the rate of absorption of the colloid dye (tryptan blue) was sharply decreased. Kallikrein somewhat increased the absorption rate, especially at early terms while the inhibitor (kontrikal) was shown to substantially decrease it. The mode of injection (intravenous or intraperitoneal) failed to influence manifestations of the biological effect of the drug. The data obtained show that a disturbed absorption from the abdominal cavity may be corrected in acute peritonitis by injections of kallikrein.
D000005:Abdomen / Q000187:drug effects* / Q000378:metabolism; D000042:Absorption; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007610:Kallikreins / Q000627:therapeutic use*; D008297:Male; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014343:Trypan Blue / Q000378:metabolism
D007611:Aprotinin; D007610:Kallikreins; D014343:Trypan Blue
Vliianie kallikreina i ego ingibitora na vsasyvanie iz briushnoĭ polosti pri peritonite.