Intertypic cross-reactions of nonneutralizing, monoclonal poliovirus antibodies.
Quantitative data are presented on (i) the intertypic cross-reactions of polyclonal, guinea pig antibodies directed against the N or H antigen of type 1 poliovirus and (ii) a set of five nonneutralizing, mouse hybridoma antibodies raised against N antigen or a mixture of capsid polypeptides VP1, VP2, and VP3. Three of these antibodies recognize H antigen and VP1, the fourth H antigen only, and the fifth VP3 only. The antibodies recognize either only homotypic antigens or the antigens of the three serotypes.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D002213:Capsid / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis; D006168:Guinea Pigs; D051379:Mice; D017955:Poliovirus / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology; D015678:Viral Structural Proteins
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000939:Epitopes; D014764:Viral Proteins; D015678:Viral Structural Proteins