title: Acantholysis induced by proteolytic enzymes. II. Enzyme fractions produced by Trichophyton mentagrophytes.
abstract: Trichophyton mentagrophytes produces three enzyme fractions of molecular weight 65,000, 92,000 and 18,000, respectively. Normal human skin was cultivated and the specimens were subjected to electron microscopy. Enzyme fraction I showed the capacity to induce epidermal acantholysis and dermo-epidermal separation, while the other two fractions showed no proteolytic nor keratinolytic action in cultivated skin.
mesh_terms: D000051:Acantholysis / Q000473:pathology*; D046508:Culture Techniques; D004817:Epidermis / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000648:ultrastructure; D012871:Skin Diseases / Q000473:pathology*; D014249:Trichophyton / Q000201:enzymology*
chemical_list: D010447:Peptide Hydrolases