Effects of irradiation on grafted skin.
The reaction of grafted skin to irradiation was studied in the rat and the optimum time for irradiation postoperatively was determined. There was a close correlation between the radiosensitivity and the vascularity of the graft and its recipient bed. Grafts showed different reactions depending on the time of irradiation after grafting. Those in the early hypovascular stage showed reactions similar to those of normal control skin. Severe reactions were observed in the hypervascular stage. Grafts in the late hypovascular stage showed more moderate reactions.
D000818:Animals; D008297:Male; D009389:Neovascularization, Pathologic; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply / Q000528:radiation effects*; D016038:Skin Transplantation; D013997:Time Factors