title: The identification of suppressor cells in the murine fetal liver.
abstract: Fetal suppressor cells are potentially important for maintenance of pregnancy and for the immune regulation of the identification of self. We have identified and partially characterized a population of murine fetal liver cells which are active suppressors of a variety of immune responses, including mixed lymphocyte responses (MLR), responses to mitogens, and plaque-forming cell responses to heterologous erythrocytes. The suppression is non-H-2-restricted and can act via a factor. The cell is preactivated in fetal liver and may represent a T-cell precursor. The suppression of MLR is maximal (approximately 100%) if cells are added within the first 48 h of culture initiation. The characteristics of this suppressor cell are compared to other known MLR and perinatal suppressor systems.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D002448:Cell Adhesion; D002469:Cell Separation; D000939:Epitopes; D005260:Female; D005333:Fetus / Q000276:immunology*; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007700:Kinetics; D008099:Liver / Q000166:cytology / Q000276:immunology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D000939:Epitopes; D006183:H-2 Antigens