Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone.
Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused regression of large tumor masses, and prevented metastases. Oral administration of heparin resulted in the release of non-anticoagulant heparin fragments in the serum which, in the presence of cortisone, had similar anti-angiogenic and antitumor effects. Of all the heparin fragments tested, the most potent inhibition of angiogenesis in the presence of cortisone was provided by a hexasaccharide with a molecular weight of about 1600.
D000818:Animals; D000970:Antineoplastic Agents; D002642:Chick Embryo; D003348:Cortisone / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D007249:Inflammation; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000098:blood supply; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D009844:Oligosaccharides / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009844:Oligosaccharides; D006493:Heparin; D003348:Cortisone