[Effect of substance P on dopamine-beta-hydroxylase and phenethanolamine-N-methyltransferase in the adrenal glands of rats].
Resulting from literature data concerning interactions between catecholamines and Substance P (SP) the influence of SP on the activity of dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) was studied in rat adrenals. Intraperitoneal application of SP (500 micrograms/kg) to male Wistar rats 15 minutes before decapitation induced a decrease of PNMT activity in the adrenals, while DBH activity remained unchanged. After incubation of adrenals with SP (10(-6) mol/l) a decrease of activity of both PNMT and DBH was observed. The experimental results are discussed in connection with a normalizing function of SP during stress induced disorders.
D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D006801:Humans; D008297:Male; D010625:Phenylethanolamine N-Methyltransferase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000201:enzymology; D013373:Substance P / Q000494:pharmacology*
D002395:Catecholamines; D013373:Substance P; D004299:Dopamine beta-Hydroxylase; D010625:Phenylethanolamine N-Methyltransferase
Zur Wirkung von Substanz P auf Dopamin-beta-Hydroxylase und Phenylethanolamin-N-Methyltransferase in der Nebenniere der Ratte.