The inhibition of rat renin in sodium depleted and renal hypertensive rats. Comparison of purified antibodies or Fab fragments against mouse submaxillary renin with SQ 20881, and the effect on blood pressure homeostasis.
Studies were undertaken in order to demonstrate the role of the renin-angiotensin system for blood pressure homeostasis in sodium depleted and renal hypertensive (acute and chronic) rats. Purified antibodies and Fab fragment against mouse submaxillary were able to complete inhibited plasma activity in rats. The depressor response was compared with the converting enzyme inhibitor teprotide SQ20881. Teprotide, showed an additional depressor response indicating that effect of converting enzyme blockade is due to factors other than renin-angiotensin blockade.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects; D006977:Hypertension, Renal / Q000201:enzymology*; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D012083:Renin / Q000276:immunology; D012084:Renin-Angiotensin System / Q000187:drug effects; D012964:Sodium / Q000172:deficiency*; D013363:Submandibular Gland / Q000201:enzymology; D013722:Teprotide / Q000494:pharmacology*; D013997:Time Factors; D000092502:Renin Inhibitors
D005665:Furosemide; D007140:Immunoglobulin Fab Fragments; D009842:Oligopeptides; D012083:Renin; D012964:Sodium; D013722:Teprotide; D000092502:Renin Inhibitors