[Pharmacokinetics of dihydrostreptomycin, after intravenous administration as a liposomal preparation, in the blood serum and tissues of intact mice and those with generalized tuberculosis].
Distribution of 3H-dihydrostreptomycin ( DHS ) in the blood serum and organs of intact mice and mice with generalized tuberculosis was studied. The antibiotic was administered in the form of a liposomal preparation and solution. It was shown that the distribution pattern of DHS administered in the form of a liposomal preparation corresponded to that of liposomes, which were the drug carriers. The serum levels of DHS injected intravenously in the form of a liposomal drug in a dose of 1 mg per mouse in the intact animals were 19 and 17 times higher 1 and 3 hours after injection, respectively as compared to those provided by the solution. In animals with generalized tuberculosis, the respective figures were 5 and 1.9 times. The levels of DHS in the liver provided by the liposomes were 4-6 times higher at all the time intervals in both the groups of animals. The antibiotic levels in the spleen of intact and infected animals were 2.5-3 and 8-12 times higher, respectively. In the lungs of intact animals, the antibiotic levels were 2 times higher 1 hour after administration. In infected animals, the levels of the antibiotic in the lung tissue were 3 times higher in 1 and 3 hours. The DHS levels in the kidneys of infected and intact animals were similar after drug administration in the form of a solution and liposomal preparation. The extremely high difference in the DHS levels in the spleen tissues of the mice with generalized tuberculosis after drug administration in the form of a solution and liposomal preparation may be of a significant importance for sanation of the organ lymphoid system affected with tuberculosis.
D000818:Animals; D001682:Biological Availability; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008081:Liposomes / Q000008:administration & dosage; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000378:metabolism; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D008081:Liposomes; D004096:Dihydrostreptomycin Sulfate
Farmakokinetika digidrostreptomitsina posle vnutrivennogo vvedeniia liposomal'nogo preparata v syvorotke krovi i tkaniakh intaktnykh i porazhennykh generalizovannym tuberkulezom mysheĭ.