title: Drug suppression of the angiotensin system in congestive heart failure.
abstract: Congestive heart failure is frequently associated with elevated systemic vascular resistance. Lowering resistance can improve cardiac performance and alleviate symptoms. The angiotensin-converting enzyme inhibitors offer a new way to lower resistance and have certain advantages, including the inhibition of compensatory mechanisms. However, skillful use of these compounds demands a thorough understanding of their pharmacologic properties and of the pathophysiology of congestive heart failure.
mesh_terms: D000804:Angiotensin II / Q000031:analogs & derivatives*; D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012504:Saralasin / Q000627:therapeutic use*; D013722:Teprotide / Q000627:therapeutic use
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D002216:Captopril; D013722:Teprotide; D012504:Saralasin