T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells.
We studied lines of rat T cells, specifically reactive against myelin basic protein (BP), that were functional in mediating autoimmune encephalomyelitis or in vaccinating rats against induction of active EAE. Herein we report that these functions depended on activation of the cells by incubation with BP or with a T cell mitogen prior to inoculation into recipient rats. Activation was accompanied by the exposure of membrane-binding sites specific for the lectin peanut agglutinin. Accumulation of activated line cells in the central nervous system and thymus gland was observed.
D000818:Animals; D010367:Arachis / Q000276:immunology; D001921:Brain / Q000276:immunology*; D002460:Cell Line; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D037102:Lectins / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D004676:Myelin Basic Protein / Q000276:immunology; D009928:Organ Specificity; D019887:Peanut Agglutinin; D037121:Plant Lectins; D051381:Rats; D011975:Receptors, Mitogen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*; D014611:Vaccination
D037102:Lectins; D004676:Myelin Basic Protein; D019887:Peanut Agglutinin; D037121:Plant Lectins; D011975:Receptors, Mitogen; C038223:peanut agglutinin receptor