[Antigenic types of interferons produced by several human lymphoblastoid cells].
There are two antigenic types of human virus-induced interferons (IFNs): one is a human leukocyte IFN (Hu IFN-alpha and the other is a human fibroblast IFN (Hu IFN-beta). We examined the antigenic types of IFNs produced in several human T and B lymphoblastoid cell lines through the induction by Sendai virus. We could produce IFNs in the several human T lymphoblastoid cells (RPMI 8402, Peer, JM and CCRF-CEM) and in several human B lymphoblastoid cells (BALL-1, B35M, DG-75 and ARH-77), and examined antigenic types of the IFNs produced. The results showed that all T lymphoblastoid cells produced Hu IFN-beta. On the other hand, the antigenic types of IFN were dependent on each cell line in human B lymphoblastoid cell lines. The IFN produced in BALL-1 cell was only one type of Hu IFN-alpha. The IFNs produced in ARH-77 and DG-75 cells contained two types of the Hu IFN-alpha and Hu IFN-beta. The IFN produced in B35M cell was only one type of Hu IFN-beta. It was concluded that human T lymphoblastoid cell produced Hu IFN-beta, and that the first type of human B lymphoblastoid cell produced only Hu IFN-alpha, the second type produced Hu IFN-alpha and Hu IFN-beta and the third type produced only Hu IFN-beta.
D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D000939:Epitopes / Q000032:analysis*; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D007370:Interferon Type I
Types antigéniques des interférons produits dans quelques cellules lymphoblastoïdes humaines.