title: [Effect of sulfochloranthine on protein and nucleic acid biosynthesis in Escherichia coli].
abstract: Sulfochloranthine was shown to be bacteriostatic for Escherichia coli B cells grown in a chemically defined medium at a concentration of 0.002%, sublethal at a concentration of 0.005%, and lethal at 0.01% (0.000312, 0.00078 and 0.00156% of active chlorine, respectively). Protein synthesis by E. coli B cells was noticeably inhibited when the concentration of the preparation was 0.002%, and stopped completely at a 0.01% concentration of the preparation. Biosynthesis of nucleic acids, in particular DNA, was inhibited to a lesser extent. The bacteriostatic concentration of the preparation had virtually no effect on DNA biosynthesis, but inhibited RNA biosynthesis by 50%. Sulfochloranthine used at sublethal doses inhibited synthesis of both DNA and RNA by 75%; DNA and RNA biosynthesis ceased at the lethal concentration of the preparation.
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis*; D004269:DNA, Bacterial / Q000096:biosynthesis*; D004202:Disinfectants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D006827:Hydantoins / Q000494:pharmacology*; D011122:Polyphosphates / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000096:biosynthesis*
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004202:Disinfectants; D004338:Drug Combinations; D006827:Hydantoins; D011122:Polyphosphates; D012329:RNA, Bacterial; C022876:sulfochloranthine
vernacular_title: Vliianie sul'fokhlorantina na biosintez belka i nukleinovykh kislot Escherichia coli.