Polymorphism of T- and B-cell sensitization by aggregate-freed heterologous gamma-globulin.
Female A/J, C57BL/6J, SJL/J, MRL/MpJ-+/+, MRL/MpJ-lpr/lpr, NZB/BINJ and male BXSB/MpJ mice were injected at various ages with a tolerogenic form of rabbit gamma-globulin, or were left untreated and all were then immunized with dinitrophenylated rabbit gamma-globulin. We could distinguish 4 types of responsiveness to sRGG: (1) persistent T-cell tolerance (A/J, MRL/MpJ-+/+); (2) persistent T-cell tolerance and age-dependent resistance and sensitization of B-cells to tolerance induction (C57BL/6J, NZB/BINJ); (3) decreasing T- and B-cell tolerance (SJL/J, male BXSB/MpJ); and (4) T-cell sensitization in older animals (MRL/MpJ-lpr/lpr). Suppressor capacity and its regeneration was examined in terms of colchicine and cyclophosphamide treatment. Colchicine increased the immune response to a much greater extent in 10-week-old than in 6-week-old MRL/MpJ-lpr/lpr mice and had little effect on MRL/MpJ-+/+ mice. It had a relatively small effect on 15-week-old NZB/B1NJ and a much greater effect on 6-week-old animals. The reason for these differences are discussed.
D000375:Aging; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D003078:Colchicine / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D011110:Polymorphism, Genetic; D011817:Rabbits; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D005719:gamma-Globulins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*
D004136:Dinitrobenzenes; D046911:Macromolecular Substances; D005719:gamma-Globulins; D003520:Cyclophosphamide; D003078:Colchicine