[Protective effect of ranitidine in acute experimental pancreatitis in the rat].
Acute experimental pancreatitis was induced in rats, with a polyethylene splint placed into the duodenum, by the closed duodenal loop technique. Ranitidine (20 mg . kg-1) or saline were administered intraperitoneally every 8 hrs, beginning 15 min prior to surgery. The degree of pancreatitis and the amylase to creatinine clearance ratio (ACCR) were evaluated in all the animals after sacrifice. Ranitidine-treated animals showed significant by reduced pancreatic damage and ACCR values in comparison with non-treated rats. These data confirm the efficacy of ranitidine as a preventive agent in the development of acute pancreatitis and suggest that controlled trials should be performed with this H2-antagonist in the human subyects with this disease.
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D003404:Creatinine / Q000378:metabolism; D005663:Furans / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D008297:Male; D010195:Pancreatitis / Q000188:drug therapy*; D011899:Ranitidine; D051381:Rats; D011919:Rats, Inbred Strains
D005663:Furans; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D003404:Creatinine; D000681:Amylases
Effetto protettivo della ranitidina sulla pancreatite acuta sperimentale nel ratto.