Biochemical investigation on the abnormal behaviors induced by fumitremorgin A, a tremorgenic mycotoxin to mice.
The relationships between behavioral responses and levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in brain of mice were investigated after intravenous injection of fumitremorgin A (FTA). The latent periods to the onset of tremor, clonic convulsion, tonic convulsion and death induced by FTA are observed in a dose-dependent fashion. However, the dose-dependency is not observed between levels of 5-HT and 5-HIAA and activities of 5-HT metabolizing enzymes in brain of FTA-treated mice. Insignificant participation of serotonergic mechanism in modulation of those behavioral states elicited by FTA is conclusively suggested.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007192:Indenes / Q000633:toxicity*; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced; D012701:Serotonin / Q000378:metabolism; D014202:Tremor / Q000139:chemically induced*
D007192:Indenes; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C024743:Fumitremorgin A