Response of transcortin and alpha 2u-globulin to turpentine-induced inflammation in the rat: influence of corticosteroids and prolactin.
Evidence is presented that (transcortin and alpha 2u-globulin react as negative acute-phase proteins in the rat. Thirty-six hours after turpentine injection, the serum concentration of these proteins showed a two- to threefold decrease. Thereafter, transcortin rapidly returned to normal values, whereas alpha 2u-globulin remained low. This reaction pattern was still present after adrenalectomy, adrenalectomy and administration of glucocorticoids, and after treatment with bromocriptine, a suppressor of prolactin secretion. It is concluded that changes in the secretion of glucocorticoids and prolactin are not required for the observed turpentine-induced decrease of transcortin and alpha 2u-globulin.
D000315:Adrenalectomy; D000510:Alpha-Globulins / Q000097:blood*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D003345:Corticosterone / Q000502:physiology*; D003907:Dexamethasone / Q000494:pharmacology; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D008297:Male; D011388:Prolactin / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014156:Transcortin / Q000097:blood*; D014425:Turpentine
D000510:Alpha-Globulins; C013803:alpha 2u globulin; D001971:Bromocriptine; D003907:Dexamethasone; D011388:Prolactin; D014156:Transcortin; D003345:Corticosterone; D014425:Turpentine