Axoplasmic transport block reduces ectopic impulse generation in injured peripheral nerves.
Afferent fibers ending in nerve end neuromas in rats generate a substantial ectopic discharge and are sensitive to light pressure and to circulating adrenaline. Treatment of the nerve with colchicine or vinblastine at the time of the nerve section resulted in a dose-dependent reduction in the extent of this discharge. Such treatment also reduced neuroma discharge that had already gotten underway.
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D001369:Axons / Q000502:physiology; D003078:Colchicine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D009407:Nerve Block; D009411:Nerve Endings / Q000502:physiology; D009463:Neuroma / Q000503:physiopathology; D009475:Neurons, Afferent / Q000502:physiology*; D010146:Pain / Q000503:physiopathology; D059348:Peripheral Nerve Injuries; D010524:Peripheral Nervous System Neoplasms / Q000503:physiopathology; D051381:Rats; D009435:Synaptic Transmission; D014747:Vinblastine / Q000494:pharmacology
D014747:Vinblastine; D003078:Colchicine; D004837:Epinephrine