Induction of T-cell proliferation by an Ia+ monocytic tumor clone.
Ia+ immature malignant monocyte clones were isolated from retrovirus-induced lymphomas. These lymphomas contained a predominant population of Ly-1+ T cells. In order to explain this anomaly, the functional capacity of one of these clones, ORA I-a, was assessed. The results indicated that ORA I-a could present protein antigen to syngeneic and semisyngeneic antigen-primed lymph node T cells. Allogeneic stimulation, however, could not be induced. Furthermore, ORA I-a-conditioned medium could augment mitogen-dependent and -independent thymocyte proliferation. These studies suggest that the unique populations of malignant antigen-presenting cells can interact with distinct T-cell subpopulations. Functional analyses of these tumor cell lines may thus be useful in elucidating some of the cellular interactions which occur during the course of immunity.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D000939:Epitopes; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007375:Interleukin-1 / Q000096:biosynthesis; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000276:immunology*; D010641:Phenotype; D012192:Retroviridae Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1