title: Effect of guanine derivatives on lordosis behavior in estrogen primed rats.
abstract: The effect of systemic administration of guanosine, cGMP, dipalmitoyl (dp) cGMP, 5'GMP and 5'GDP on lordosis behavior was studied in ovariectomized, estradiol benzoate (EB) primed rats (4 micrograms/rat). EB per se induced only weak lordosis behavior. Free cGMP (2.0 mg/rat); dp cGMP (1.0, 2.0 and 4.0 mg/rat) and 5'GMP (2.0 and 4.0 mg/rat) induced significant lordosis behavior in ovariectomized, estrogen-primed rats. Dp cGMP and 5'GMP (2.0 mg/rat), also induced lordosis behavior in ovariectomized, adrenalectomized estrogen primed rats. Lordosis behavior elicited with 2.0 mg/rat dp cGMP was blocked with 8.0 mg/rat methyl-isobutylxanthine (MIX), a phosphodiesterase inhibitor, suggesting that dp cGMP stimulated lordosis through its conversion to 5'GMP. Results are interpreted in terms of the activation of adenylate cyclase-cAMP systems by guanine nucleotides.
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D002369:Castration; D006152:Cyclic GMP / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives*; D006151:Guanosine / Q000494:pharmacology; D006153:Guanosine Diphosphate / Q000494:pharmacology; D006157:Guanosine Monophosphate / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D006151:Guanosine; D006153:Guanosine Diphosphate; D004958:Estradiol; D006147:Guanine; D006157:Guanosine Monophosphate; D006152:Cyclic GMP; D015056:1-Methyl-3-isobutylxanthine