title: Mechanism of enhanced RNA synthesis in acute-phase rat liver and its relationship to chromatin structure.
abstract: Nuclei isolated from the liver of rats undergoing an acute inflammatory reaction induced by turpentine treatment show increased RNA synthesis. This increase is essentially determined by a faster polyribonucleotide-elongation rate while the number of transcribing polymerase molecules is unchanged. The sensitivity of chromatin to micrococcal-nuclease digestion and the composition of chromosomal proteins are not affected by the acute-phase process. Therefore the increased RNA synthesis by liver nuclei from acutely inflamed rats does not seem to correlate with major changes in chromatin structure.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D008099:Liver / Q000378:metabolism*; D008297:Male; D008836:Micrococcal Nuclease; D011119:Polynucleotides / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014158:Transcription, Genetic; D014425:Turpentine
chemical_list: D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D011119:Polynucleotides; D012313:RNA; D012321:DNA-Directed RNA Polymerases; D008836:Micrococcal Nuclease; D014425:Turpentine