[Peptide therapy of sleep disorders in neurotic rats].
As a result of chronic stress, anxiety appeared in the rats behaviour, motor activity increased, heart rate quickened, blood pressure raised, conditioned instrumental alimentary reflexes missed, the duration of deep phases of sleep lowered, time of falling asleep became longer, the number of awakening increased. The change in quantitative characteristics of sleep was accompanied by its worsening, especially of rapid sleep. Administration of substance P (SP) eledoisin hexopeptide (EH) (250 mcg/kg), 100-200 mcg/kg of delta sleep peptide and 10 mcg/kg of ethylcrotyl barbiturate improved the rats behaviour and sleep parameters. Calipnon accelerated falling asleep. Delta sleep peptide increased sleep duration. SP and EH restored not only the quantitative characteristics of deep phases of sleep but greatly improved their quality: lowered the blood pressure disrupted tachycardia, normalized the conditioned activity.
D000818:Animals; D001463:Barbiturates / Q000031:analogs & derivatives / Q000627:therapeutic use; D003216:Conditioning, Operant / Q000502:physiology; D003701:Delta Sleep-Inducing Peptide; D004600:Eledoisin / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D009497:Neurotic Disorders / Q000150:complications* / Q000503:physiopathology; D009842:Oligopeptides / Q000627:therapeutic use; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology; D013373:Substance P / Q000627:therapeutic use
D001463:Barbiturates; D006993:Hypnotics and Sedatives; D009842:Oligopeptides; D010455:Peptides; C019092:substance P analog(eledoisin related peptide); D013373:Substance P; D004600:Eledoisin; D003701:Delta Sleep-Inducing Peptide; C000517:crotarbital
Peptidnaia terapiia rasstroĭstv sna u nevrotizirovannykh krys.