The mechanisms underlying potentiation of recruiting responses may include GABA-disinhibition.
Potentiation of recruiting responses has been demonstrated to occur in the course of development of generalized epilepsy in the cat (Kostopoulos and Avoli 1983). A similar potentiation of RR of cortical neurons was demonstrated here after microiontophoretic application of bicuculline. The release of cortical neurons from a GABA-mediated inhibition or another mechanism more sensitive to bicuculline may underly both these phenomena.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004827:Epilepsy / Q000378:metabolism*; D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline