Hamster endogenous retrovirus (HaER) isolated from SV-40 induced tumor cells.
A hamster cell line obtained from a secondary transplanted SV-40-induced tumor was found to spontaneously release type C virus particles. The particles possessed all biochemical features characteristic of retroviruses and induced syncytium formation in XC cells but were not oncogenic for hamsters. Nucleic acid hybridization assays demonstrated that the isolated virus was an endogenous retrovirus of hamster, lacking sequence homology with mouse and other animal species.
D000818:Animals; D002460:Cell Line; D002499:Centrifugation, Density Gradient; D006224:Cricetinae / Q000382:microbiology*; D003588:Cytopathogenic Effect, Viral; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000209:etiology / Q000382:microbiology*; D012367:RNA, Viral / Q000032:analysis; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012190:Retroviridae / Q000302:isolation & purification* / Q000648:ultrastructure; D013539:Simian virus 40; D014412:Tumor Virus Infections / Q000382:microbiology*
D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase