[Heparin and antiheparin in childhood. 3. Heparin level measurements and their importance in heparin monitoring].
Measurements of the heparin level were made under continuous anticoagulation in a total of 7 patients. For the purpose of monitoring heparin the coagulation time values were determined parallelly. Except a patient with a sepsis and a 7 days old newborn baby the desired prolongation for the partial thromboplastin time and the reaction time of thrombelastogram resulted from heparin titres lying within the range of 0.2-0.7 U/ml of plasma. Even after applying depot preparations there was a relatively good correspondance of heparin level curves and coagulation parameters. In childhood the partial thromboplastin time is primarily suitable for monitoring the heparin therapy. Heparin half-life times calculated during the transumbilical exchange transfusion in 7 children amounted to values ranging between 40-110 minutes. In addition to checking low dose heparinizing, measurements of the level are suitable for deriving dosage standards for neutralizing heparin effects by protamine sulfate.
D000293:Adolescent; D001777:Blood Coagulation; D002648:Child; D006493:Heparin / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010314:Partial Thromboplastin Time; D013916:Thrombelastography; D013918:Thrombin Time; D013923:Thromboembolism / Q000097:blood / Q000517:prevention & control*
D006493:Heparin
Heparin und Antiheparin im Kindesalter. 3. Mitteilung: Heparinspiegelmessungen und ihre Bedeutung für das Heparinmonitoring.