Vi serology in detection of chronic Salmonella typhi carriers in an endemic area.
A passive haemagglutination assay measuring antibody to highly purified Vi antigen, known to be sensitive and specific for the detection of chronic Salmonella typhi carriers in a non-endemic area, was assessed in an endemic area. A reciprocal serum Vi antibody titre of 160 was found to have a sensitivity of 75%, specificity of 92%, and a high predictive value in screening for chronic S typhi carriers in high-risk population group (eg, women over 40 years). This simple assay can screen for chronic S typhi carriers even in areas where typhoid fever is highly endemic.
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000032:analysis*; D002353:Carrier State / Q000175:diagnosis*; D002677:Chile; D002908:Chronic Disease; D000939:Epitopes; D005260:Female; D006386:Hemagglutination Tests / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011135:Polysaccharides, Bacterial; D012485:Salmonella typhi / Q000276:immunology; D014435:Typhoid Fever / Q000175:diagnosis* / Q000453:epidemiology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000939:Epitopes; D011135:Polysaccharides, Bacterial