Monoclonal antibodies against human paramyxovirus type 3 and against SV5 virus: preparation and preliminary characterization.
Monoclonal antibodies against the major glycoprotein (HN) and the nucleoprotein (NP) of paramyxovirus SV5 and human paramyxovirus (PF) type 3 have been obtained. Two different epitopes have been detected on the SV5 HN polypeptide, one being specific to SV5 and the other also cross-reacting with PF-2 HN polypeptide. Monoclonal antibody against SV5 NP polypeptide also reacted with PF-2 NP polypeptide. Similar epitopes showing both specific and group cross-reactions were detected with PF-3 HN and NP monoclonal antibodies against PF-3 and Sendai viruses. No cross-reactions were detected between these two groups of paramyxoviruses.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D015707:HN Protein; D006825:Hybridomas; D009500:Neutralization Tests; D009698:Nucleoproteins / Q000276:immunology; D010252:Paramyxoviridae / Q000276:immunology*; D011233:Precipitin Tests; D011863:Radioimmunoassay; D014764:Viral Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes; D015707:HN Protein; D009698:Nucleoproteins; D014764:Viral Proteins