Naturally occurring anti-interferon antibodies in Lou/c rats.
Rats of the Lou/c strain have natural antibodies with binding and neutralizing activity against mouse and rat interferon. The antibodies can be purified on a column of goat IgG directed against rat IgG, and they have an affinity for protein A-Sepharose. They are already present in very young (2-wk-old) animals, and the titers increase with increasing age.
D000375:Aging; D000818:Animals; D000906:Antibodies / Q000302:isolation & purification / Q000502:physiology*; D001666:Binding Sites, Antibody; D001790:Blood Physiological Phenomena; D002846:Chromatography, Affinity; D002847:Chromatography, Agarose; D007113:Immunity, Innate; D007372:Interferons / Q000276:immunology*; D008297:Male; D008970:Molecular Weight; D009500:Neutralization Tests; D051381:Rats; D011919:Rats, Inbred Strains; D013205:Staphylococcal Protein A
D000906:Antibodies; D013205:Staphylococcal Protein A; D007372:Interferons