In vitro myelin basic protein synthesis in the PNS and CNS of myelin deficient (mld) mutant mice.
The CNS of the mutant mld has a severe myelin deficit. In contrast, myelination is normal in the PNS. Previous studies showed that myelin basic proteins (MBP) are practically missing in mld CNS and PNS tissues. Using an in vitro system and immunoprecipitation, we present evidence that MBP synthesis is repressed in the PNS and in the CNS of mld mutants.
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D051379:Mice; D008818:Mice, Neurologic Mutants; D004676:Myelin Basic Protein / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism*; D009900:Optic Nerve / Q000378:metabolism; D010525:Peripheral Nerves / Q000378:metabolism*; D012584:Sciatic Nerve / Q000378:metabolism
D004676:Myelin Basic Protein