Interaction between prolactin and zinc in the human prostate gland.
The interaction between prolactin and zinc was examined in vitro in the human prostate gland. The results indicated that prolactin did not modulate the acute uptake of zinc into benign prostatic hypertrophy tissue whereas zinc, in contrast, increased the uptake of prolactin into the prostate gland. Our study further showed that the augmented uptake of prolactin by zinc was partly due to an increase in the non-specific binding properties of the peptide hormone. We were also able to demonstrate that the specific binding of 125I-labelled human prolactin to the receptor was reduced in the presence of zinc by a competitive mechanism.
D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011388:Prolactin / Q000378:metabolism* / Q000494:pharmacology; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D011981:Receptors, Prolactin; D015032:Zinc / Q000378:metabolism* / Q000494:pharmacology
D011956:Receptors, Cell Surface; D011981:Receptors, Prolactin; D011388:Prolactin; D015032:Zinc