Photosensitivity induced by piroxicam.
A woman with rheumatoid arthritis developed an erythematous-bullous eruption on light-irradiated areas following sun exposure. Treatment with piroxicam, had been initiated 14 days earlier. The clinical picture, the relationship in time to the drug administration and a positive photopatch test gave reason to suspect piroxicam-induced photosensibility. Piroxicam (Felden) is a new non-steroid anti-inflammatory agent which was registered in Sweden in 1981. Various adverse skin reactions have been described. Thus, there has been one case of Lyell's syndrome with a fatal outcome (7), two case reports of erythema multiforme-like reactions (1, 3) and two reports of patients with erythemato-papulous and also bullous eruptions restricted to light-exposed skin areas (3).
D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D003875:Drug Eruptions / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000473:pathology; D010894:Piroxicam; D013843:Thiazines / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam