Large scale production of human interferon from human spleens.
In an attempt to increase the production of human interferon, human spleen appeared as a possible useful organ for large scale production of the substance. White cells provided by spleens were incubated in the presence of Sendaï Virus. Results showed that one spleen was capable to produce more than 10(8) units of interferon per spleen. The use of human spleen cells for interferon production seems interesting not only in the aim of casual therapeutic assays, but also for new basic researches on human alpha or gamma interferon, since large amounts of interferon can be obtained from a single person.
D002478:Cells, Cultured; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D010222:Parainfluenza Virus 1, Human; D013154:Spleen / Q000378:metabolism*
D007372:Interferons