Immune rabbit sera do not recognize antigenic variants of caprine arthritis-encephalitis virus isolated during persistent infection.
Isolates of caprine arthritis-encephalitis virus recovered 12 to 18 months after infection of goats were tested for neutralization by using rabbit antisera directed to the original inoculum virus. Only slight differences in neutralization kinetics between the long-term isolates and the original virus were detected, indicating that heterologous rabbit antisera do not detect antigenic variation of the neutralizing epitopes of caprine arthritis-encephalitis virus.
D000820:Animal Diseases / Q000382:microbiology*; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D001170:Arthritis, Infectious / Q000382:microbiology / Q000662:veterinary*; D004660:Encephalitis / Q000382:microbiology / Q000662:veterinary*; D000939:Epitopes / Q000032:analysis; D014644:Genetic Variation; D006041:Goats / Q000382:microbiology*; D012401:Rotavirus / Q000276:immunology* / Q000302:isolation & purification
D000956:Antigens, Viral; D000939:Epitopes