[Antiviral action of monoclonal antibodies].
The antiviral effect of monoclonal antibodies MAK-14-7 possessing the neutralizing activity was studied on the model of Venezuelan equine encephalomyelitis virus in cell cultures and in experimentally infected laboratory animals. Mouse monoclonal antibodies exerted a marked specific antiviral effect in tissue culture and in white mice inhibiting virus reproduction by 1-3-5 log PFU/ml. The degree of inhibition of virus reproduction is inversely proportional to the multiplicity of infection. When used in combination with remantadine, ribavirin, interferon, and its inducer poly (I) X poly (C), the monoclonal antibodies MAK-14-7 exerted additive antiviral effect.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity; D004666:Encephalitis Virus, Venezuelan Equine / Q000187:drug effects / Q000276:immunology*; D004685:Encephalomyelitis, Venezuelan Equine / Q000276:immunology; D007372:Interferons / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D011070:Poly I-C / Q000494:pharmacology; D012254:Ribavirin / Q000494:pharmacology; D012299:Rimantadine / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000276:immunology*; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D012299:Rimantadine; D012254:Ribavirin; D007372:Interferons; D011070:Poly I-C
Protivovirusnoe deĭstvie monoklonal'nykh antitel.