The major B and T cell determinant on pigeon cytochrome c in B10.a mice.
The specificities of B10.A B and T cells responding to pigeon cytochrome c have been examined. Proliferating T cells recognize glutamine 100 and lysine 104 and can be stimulated in vitro by either native cytochrome c molecules or certain of their CNBr-cleavage fragments. In contrast only molecules with the native cytochrome c conformation were found to interact with B10.A antipigeon cytochrome c antibodies. Antibodies appear to recognize a determinant or determinants which overlaps with that which elicits the T cell proliferative response.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D010856:Columbidae; D003574:Cytochrome c Group / Q000276:immunology*; D000939:Epitopes; D008213:Lymphocyte Activation; D051379:Mice; D011487:Protein Conformation; D011946:Receptors, Antigen / Q000276:immunology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology*
D003574:Cytochrome c Group; D000939:Epitopes; D011946:Receptors, Antigen