Effects of substance P on Na and K transport in perfused main submandibular duct of rat.
Substance P (2 and 4 micrograms/kg . min, iv) caused an inhibition of net efflux of Na and net influx of K in perfused main excretory duct of rat submandibular gland. These effects could not be blocked by atropine sulfate. The data suggest that substance P receptors are present in the duct cells and play a role in the regulation of transductal electrolyte transport.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D008297:Male; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D018040:Receptors, Neurokinin-1; D012964:Sodium / Q000378:metabolism*; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*; D013373:Substance P / Q000494:pharmacology*
D011956:Receptors, Cell Surface; D018040:Receptors, Neurokinin-1; D013373:Substance P; D001285:Atropine; D012964:Sodium; D011188:Potassium