Modifications in pancreatic enzyme proportions following secretory stimulations.
The short-term influence of repeated secretory stimulations of the pancreas on pancreatic enzyme content was studied in the rat. The animals received 10 successive injections of either cholecystokinin-pancreozymin (CCK-PZ), secretin, CCK-PZ plus secretin, caerulein or pilocarpine. The pancreatic enzyme content was determined the next morning. CCK-PZ, with or without secretin, caerulein and pilocarpine had a similar influence increasing the chymotrypsinogen concentration in the pancreas twofold, while lipase and amylase concentrations increased by only 50 and 25%, respectively. Fasted and fed animals responded similarly. Secretin, a mostly ductal secretagogue, was without influence on the pancreatic enzyme composition. Thus, the mere stimulation of pancreatic protein secretion seems to result in a rapid change in enzyme composition in the pancreas.
D000681:Amylases / Q000378:metabolism; D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology*; D002919:Chymotrypsinogen / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012633:Secretin / Q000494:pharmacology*; D013268:Stimulation, Chemical
D010862:Pilocarpine; D012633:Secretin; D002108:Ceruletide; D002766:Cholecystokinin; D002919:Chymotrypsinogen; D008049:Lipase; D000681:Amylases