title: Infantile autism and the temporal lobe of the brain.
abstract: Studies are reviewed that support the hypothesis that infantile autism results from a neuropathology of the temporal lobes of the brain. First, there are parallels between symptoms noted in autism and those found in the Kluver-Bucy and amnesic syndromes. Second, there is a similarity between developmental dysphasia and autism. Third, the formation of cross-modal associations may be deficient in autistic children, a symptom resembling aspects of Geschwind's disconnection syndromes. Finally, a large number of organic factors have been associated with the development of autism, some of these having specific implications for temporal lobe involvement. It is concluded that the main autistic symptoms are most consistent with a neurological model involving bilateral dysfunction of the temporal lobes. Individual differences in the extent of bilateral involvement and/or other coexistent neuropathologies could contribute to the heterogeneity of the autistic population.
mesh_terms: D000647:Amnesia / Q000523:psychology; D000818:Animals; D001037:Aphasia / Q000473:pathology / Q000523:psychology; D001321:Autistic Disorder / Q000503:physiopathology* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D019965:Neurocognitive Disorders / Q000523:psychology; D013577:Syndrome; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology*