Immunofluorescent localization of four serum proteinase inhibitors in normal rat liver.
Four serum proteinase inhibitors, alpha 1-macroglobulin, alpha 1-proteinase inhibitor, alpha 1-inhibitor3 and alpha 2-acute phase macroglobulin, were localized in rat liver by immunofluorescent techniques. alpha 1-Macroglobulin was observed predominantly in the sinusoids and alpha 1-inhibitor3 in hepatocytes. In contrast, alpha 1-proteinase inhibitor was localized in two sites, sinusoids and parenchymal cells. The fourth inhibitor tested, alpha 2-acute phase macroglobulin, was barely detectable in normal liver. However, some appeared to be present in the extrahepatocyte space.
D000209:Acute-Phase Proteins; D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D008099:Liver / Q000032:analysis*; D008297:Male; D011480:Protease Inhibitors / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins / Q000032:analysis
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; C017894:alpha 1-inhibitor 3; D000511:alpha-Macroglobulins