title: Escherichia coli CAN lacks a tRNA-processing nuclease.
abstract: Escherichia coli strain CAN is unable to support the growth of bacteriophage T4 strains requiring the suppressor function of T4 tRNASer. Biochemical analysis of the mutant strain revealed that it is deficient in a RNase which acts on the artificial tRNA precursor tRNA-C-U.
mesh_terms: D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D009154:Mutation; D009694:Nucleic Acid Precursors / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D012322:RNA Precursors; D012323:RNA Processing, Post-Transcriptional; D012343:RNA, Transfer / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism*; D013604:T-Phages / Q000378:metabolism
chemical_list: D009694:Nucleic Acid Precursors; D012322:RNA Precursors; D012367:RNA, Viral; D012313:RNA; D012343:RNA, Transfer; D012260:Ribonucleases