Co-localization of cyclic GMP in superior cervical ganglion with peptide neurotransmitters.
The immunofluorescent localization of cyclic 3',5'-guanosine monophosphate (cyclic GMP) in rat superior cervical ganglion has been compared to postganglionic neurons having immunoreactivity to neuropeptides. Cyclic GMP-positive somata are equally distributed among cell bodies fluorescent for substance P, somatostatin, and methionine-enkephalin. 40% of the total number of cells stained for each peptide demonstrate co-incident cyclic GMP localization, suggesting a large majority of the neurons employ non-cyclic GMP mechanisms.
D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005728:Ganglia, Sympathetic / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism; D013373:Substance P / Q000378:metabolism; D009435:Synaptic Transmission
D010455:Peptides; D013373:Substance P; D013004:Somatostatin; D004744:Enkephalin, Methionine; D006152:Cyclic GMP