Non-seminomatous germ cell tumors of the testis: morphology of retroperitoneal lymph node metastases after chemotherapy.
Gross and histological examination of residual retroperitoneal mature teratoma revealed different findings in patients treated with PVB remission-induction chemotherapy with maintenance chemotherapy followed by an RLND 4-6 months after PVB chemotherapy (group I) as compared to patients who received PVB chemotherapy only and underwent an RLND after 4-6 weeks (group II). RLND specimens in group I predominantly contained mature teratoma with organoid differentiation, whereas the specimens in group II often consisted of small mature teratoma areas with less-differentiated structures next to large areas of fresh tumor necrosis. Our findings suggest that, either due to maintenance chemotherapy or due to a prolonged time interval between PVB remission-induction chemotherapy and RLND, mature teratoma grows and differentiates further from tissue level to organoid level.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D012186:Retroperitoneal Neoplasms / Q000473:pathology / Q000556:secondary*; D013724:Teratoma / Q000473:pathology / Q000556:secondary; D013736:Testicular Neoplasms / Q000188:drug therapy*; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin