Studies of antinuclear antibodies in rheumatoid arthritis.
Antinuclear antibodies (ANA) by the indirect immunofluorescence method and their immunospecificities were investigated in 60 patients with rheumatoid arthritis using HEp-2 cells as substrates. ANA were detected in 35% of the patients. The patterns of nuclear staining observed included: diffuse or patchy homogeneous (20%), speckled (8.3%), centromere (3.3%), nucleolar (1.6%) and in 1 patient a mixed pattern (1.6%). The presence of antihistone antibodies (20%) correlated with the presence of an homogeneous pattern on the HEp-2 cells.
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology*; D002466:Cell Nucleolus / Q000276:immunology; D002503:Centromere / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006657:Histones / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged
D000974:Antibodies, Antinuclear; D000939:Epitopes; D006657:Histones