title: The influence of mercury and lead compounds on the circadian rhythm of cytoplasmic RNA in hypothalamic neurons of mice.
abstract: Cytophotometric determinations of cytoplasmic RNA were performed at various hours in normal mice and those given a single injection of mercuric citrate or lead citrate. A cosinor analysis of the results has revealed a marked reduction of the amplitude of the rhythm of RNA content a shift of the acrophase to earlier hours in the experimental animals. Moreover, administration of the tested compounds caused a general reduction of the RNA content in the hypothalami.
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D007031:Hypothalamus / Q000166:cytology; D007854:Lead / Q000494:pharmacology*; D008297:Male; D008628:Mercury / Q000494:pharmacology*; D051379:Mice; D009474:Neurons / Q000378:metabolism; D009942:Organometallic Compounds; D012313:RNA / Q000096:biosynthesis*
chemical_list: D009942:Organometallic Compounds; D007854:Lead; D012313:RNA; D008628:Mercury; C029823:mercuric acetate; C008261:lead acetate