Functional and phenotypic properties of subpopulations of murine thymocytes. I. The bulk of peanut agglutinin-positive Lyt-1,2,3 thymocytes lacks precursors of cytotoxic T lymphocytes responsive to interleukin 2 (T cell growth factor).
Thymocytes were separate according to their surface phenotype and tested for cytotoxic T lymphocyte (CTL) precursor function by stimulation with allogeneic or hapten-coupled cells, with or without addition of T cell growth factor (interleukin 2). The data show that only a minor subpopulation of thymocytes agglutinated by peanut agglutinin, expressing relatively high amounts of H-2K antigen, contained CTL precursors. The remaining population, approximately 80%, could not be induced to generate CTL, even in the presence of interleukin 2.
D000818:Animals; D000950:Antigens, Ly / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000235:genetics / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000235:genetics; D005260:Female; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D006238:Haploidy; D006241:Haptens / Q000276:immunology; D007376:Interleukin-2 / Q000494:pharmacology; D037102:Lectins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D019887:Peanut Agglutinin; D010641:Phenotype; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology / Q000276:immunology*
D000950:Antigens, Ly; D000961:Antilymphocyte Serum; D000939:Epitopes; D006183:H-2 Antigens; D006241:Haptens; D007376:Interleukin-2; D037102:Lectins; D019887:Peanut Agglutinin