title: Benzoyl peroxide: lack of sensitization.
abstract: A prospective study of 445 patients using benzoyl peroxide, observed regularly over a 12-month period, uncovered only a very low incidence of moderate or severe local reaction. There was, however, a significant level of mild primary irritant dermatitis which settled with continued use. In only 6 patients was there severe local reaction; one patient was lost to follow-up but in the 5 patients patch tested, only one had a contact allergic dermatitis. The study indicates the overall cutaneous safety of benzoyl peroxide.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D001585:Benzoyl Peroxide / Q000009:adverse effects / Q000276:immunology*; D003877:Dermatitis, Contact / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D010545:Peroxides / Q000276:immunology*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D010545:Peroxides; D001585:Benzoyl Peroxide