[Structuro-metabolic aspects of the effect of the adrenal cortex on the pancreas].
In experiments on male rats it was shown that hydrocortisone injection in appropriate doses renders a stimulating effect upon the acinar cell function, whereas large doses of the drug reduce the exocrine tissue secretory function, affecting its protein-synthetizing capacity, first of all. Corticosteroid deficiency is accompanied by morphofunctional atrophy of the exocrine region of the organ. Hydrocortisone and DOCA substituting therapy demonstrates that these changes are caused by glucocorticoid deficiency.
D000302:Adrenal Cortex / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000166:cytology* / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats
D010743:Phospholipids; D012313:RNA; D006854:Hydrocortisone
Strukturno-metabolicheskie aspekty vliianiia kory nadpochechnikov na podzheludochnuiu zhelezu.