RNA processing regulation of neuroendorcrine gene expression.
Alternative RNA processing events account for biological polymorphism in the endocrine, immune, and other systems; these may have possible widespread significance in the regulation of eukaryotic gene expression. The selective use of alternative hormone-encoding exons can produce multiple mRNAs generating different protein products. The resultant "peptide switching" is a previously unrecognized mechanism allowing a single gene to encode different hormones in different tissues and thus increases the diversity of endocrine gene expression.
D000818:Animals; D001483:Base Sequence; D002116:Calcitonin / Q000235:genetics; D004274:DNA, Recombinant; D004702:Endocrine Glands / Q000378:metabolism*; D005786:Gene Expression Regulation; D005814:Genes, Viral; D007136:Immunoglobulins / Q000235:genetics; D009420:Nervous System / Q000378:metabolism*; D010455:Peptides / Q000235:genetics; D011110:Polymorphism, Genetic; D012313:RNA / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats
D004274:DNA, Recombinant; D007136:Immunoglobulins; D010455:Peptides; D012333:RNA, Messenger; D012313:RNA; D002116:Calcitonin