title: Pregnancy-associated plasma protein-A (PAPP-A) and immunosuppressive activity in split ejaculates.
abstract: Pregnancy-associated plasma protein-A (PAPP-A) and phytohemagglutinin (PHA)-induced lymphocyte transformation were measured in split ejaculates of 17 normal volunteers. The concentration of PAPP-A was identical in both fractions of the ejaculate but the first fraction was twice as immunosuppressive as the second fraction. The origin of PAPP-A in men as well as its possibility of being an immunosuppressor is discussed.
mesh_terms: D004542:Ejaculation; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D011257:Pregnancy Proteins / Q000276:immunology*; D011266:Pregnancy-Associated Plasma Protein-A / Q000276:immunology* / Q000378:metabolism; D011467:Prostate / Q000378:metabolism*; D012661:Semen / Q000276:immunology* / Q000378:metabolism; D012669:Seminal Vesicles / Q000378:metabolism*
chemical_list: D010835:Phytohemagglutinins; D011257:Pregnancy Proteins; D011266:Pregnancy-Associated Plasma Protein-A