Thyrotropin, total thyroxine, thyroxine binding capacity and free thyroxine index in patients with gonadal dysgenesis (karyotype 45/XO).
In 9 patients with gonadal dysgenesis (karyotype 45/XO), the responsiveness of thyreotropic cells of the pituitary was investigated by stimulation with thyreotropin-releasing hormone (TRH). Both after hormone substitution in the form of sequential therapy (mestranol/mestranol-chlormadinone acetate) and after the end of therapy the investigations were repeated. TSH was determined by RIA, total thyroxine and binding capacity of thyroxine binding globuline (TBC-index) by protein binding assay. The free thyroxine index (FT4-index) was calculated. The results show that the hypothalamic-pituitary unit in patients with gonadal dysgenesis reacts in a similar manner as in normal female subjects.
D000293:Adolescent; D000328:Adult; D000510:Alpha-Globulins / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood*; D013975:Thyroxine-Binding Proteins / Q000032:analysis*; D014424:Turner Syndrome / Q000097:blood*
D000510:Alpha-Globulins; D013975:Thyroxine-Binding Proteins; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine