title: The neural cell adhesion molecule L1 is distinct from the N-CAM related group of surface antigens BSP-2 and D2.
abstract: The neural cell adhesion molecule L1 and the group of N-CAM related molecules, BSP-2 and D2 antigen, are immunochemically distinct molecular species. The two groups of surface molecules are also functionally distinct entities, since inhibition of Ca2+-independent adhesion among early post-natal mouse cerebellar cells by Fab fragments of both antibodies are at least additive, when compared with equal concentrations of the individual antibodies.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D002118:Calcium / Q000494:pharmacology; D002448:Cell Adhesion; D002846:Chromatography, Affinity; D000939:Epitopes / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007163:Immunosorbent Techniques; D039841:Leukocyte L1 Antigen Complex; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D012794:Sialic Acids
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments; D039841:Leukocyte L1 Antigen Complex; D012794:Sialic Acids; C038718:neural cell surface antigen BSP-2; C041372:neural cell surface antigen D2, mouse; D002118:Calcium