Surface markers of primate B and T lymphoid cell lines identified by antibodies to human and simian lymphocyte antigens.
Simian B and T lymphoid cell lines were shown to maintain surface markers found on mature lymphocytes in vivo. The T lymphoid cell lines expressed Ia-like antigens on their surfaces, further suggesting that they represent mature, activated T cells. These Ia antigens show a structural similarity to Ia on human cells although some diversity exists. The Ia antigen expressed on T lymphoid cell lines was shown to be very similar to those on B lymphoid cell lines. Owl monkey and marmoset T lymphoid cell lines were also shown to express a VH immunoglobulin-related determinant, a marker which is thought to be associated with T cell antigen receptor. Owl monkey and marmoset T cell lines express a surface antigen which identifies the sheep erythrocyte receptor on human T cells and some of these lines express an antigen found on human helper T cells. It is noteworthy that substantial conservation of surface components has occurred within primate evolution such that monoclonal antibodies to human Ia, OKT-11a and Leu 3a markers can be used to type lymphocytes of lower primates.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001029:Aotus trivirgatus; D001402:B-Lymphocytes / Q000276:immunology*; D002143:Callitrichinae; D002460:Cell Line; D002645:Chickens; D002846:Chromatography, Affinity; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology*; D006801:Humans; D006922:Hylobates; D007135:Immunoglobulin Variable Region; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D007135:Immunoglobulin Variable Region; D011947:Receptors, Antigen, B-Cell