Peripheral and central nervous actions of substance P antagonists.
Studies with the SP-analogues (D-Pro2, D-Phe7, D-Trp9)-SP and (D-Pro2, D-Trp7,9)-SP show that they inhibit the action of SP in a variety of organs both in vitro and in vivo. They also block several non-cholinergic, non-adrenergic effects of nerve activation. Experimental evidence suggest that (D-Pro2, D-Phe7, D-Trp9)-SP and (D-Pro2, D-Trp7,9)-SP are specific SP-antagonists of the competitive type with little or no agonist activity. The present data show that SP-antagonists will be of great importance in clarifying functions of SP.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D002626:Chemistry, Pharmaceutical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects*; D013373:Substance P / Q000037:antagonists & inhibitors*
D013373:Substance P