A morphologic and histochemical study of metaplastic polyps of the colorectum.
A combined morphologic and histochemical study of metaplastic polyps of the colorectum was undertaken. With increasing size, these lesions showed alterations in architecture and differentiation, increased secretion of carcinoembryonic antigen and a reduced secretion of O-acylated sialomucin. These functional changes are also observed in colorectal cancers, but not in tubular adenomas showing low-grade dysplasia. Since there is little clinical evidence for a metaplastic polyp-carcinoma sequence, it is suggested that the sets of factors which lead to adenoma and metaplastic polyp formation in the colorectum are both required to induce malignant transformation.
D002272:Carcinoembryonic Antigen / Q000032:analysis; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007417:Intestinal Polyps / Q000378:metabolism / Q000473:pathology*; D009961:Orosomucoid / Q000032:analysis; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling
D002272:Carcinoembryonic Antigen; D009961:Orosomucoid