Galanin - a novel biologically active peptide from porcine intestine.
The isolation of a novel biologically active peptide, designated galanin, is described. The peptide was discovered by the detection of its C-terminal amide structure in porcine intestinal extract using a chemical method. It was found that galanin consists of 29 amino acids and the complete amino acid sequence is: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His -Arg-Ser -Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2. Galanin was found to contract smooth muscle preparations from the rat and to cause a mild and sustained hyperglycemia in dog.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D001786:Blood Glucose / Q000378:metabolism; D019004:Galanin; D007421:Intestine, Small / Q000032:analysis*; D009119:Muscle Contraction / Q000187:drug effects; D010455:Peptides / Q000302:isolation & purification*; D051381:Rats; D013552:Swine
D000596:Amino Acids; D001786:Blood Glucose; D010455:Peptides; D019004:Galanin