Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.
The enzyme which confers resistance to erythromycin in the producing organism Streptomyces erythraeus dimethylates a single adenine residue in Bacillus stearothermophilus 23 S rRNA. This corresponds to residue Ade 2058 in Escherichia coli 23 S RNA. The methylase responsible for resistance to macrolides, lincomycin, and streptogramin B-related antibiotics in Staphylococcus aureus also acts at this site.
D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001483:Base Sequence; D004351:Drug Resistance; D004917:Erythromycin / Q000633:toxicity*; D007700:Kinetics; D008780:Methyltransferases / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D013045:Species Specificity; D013302:Streptomyces / Q000201:enzymology*; D013379:Substrate Specificity
D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D004917:Erythromycin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase