Platelet DNA polymerase levels in CML: implications for oncogenesis.
Partially purified platelet DNA polymerase (PDP) was able to synthesize DNA transcripts of platelet polyadenylated RNA. PDP was elevated in the earliest stages of CML and PV. In PV, successful chemotherapy resulted in rapid return of PDP to normal levels while in CML this was not the case. An hypothesis is presented proposing that PDP contributes to oncogenesis by regulating the expression of oncogenes.
D001792:Blood Platelets / Q000201:enzymology*; D004259:DNA-Directed DNA Polymerase / Q000097:blood*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D011289:Preleukemia / Q000201:enzymology*; D012194:RNA-Directed DNA Polymerase / Q000097:blood
D012194:RNA-Directed DNA Polymerase; D004259:DNA-Directed DNA Polymerase