An HPLC method for the simultaneous quantitation of quinidine, procainamide, N-acetylprocainamide, and disopyramide.
A high performance liquid chromatographic method is reported, which incorporates three internal standards (I-cinchonidine, N-propylprocainamide, and para-chlorodisopyramide) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: quinidine, procainamide, N-acetylprocainamide, and disopyramide. Compounds were separated using combined ion-pairing and adsorption chromatography on a silica column. Inter-run variation was 5.9 CV% for all drugs.
D000120:Acecainide / Q000032:analysis; D000889:Anti-Arrhythmia Agents / Q000032:analysis* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D004206:Disopyramide / Q000032:analysis; D006801:Humans; D011342:Procainamide / Q000032:analysis; D011802:Quinidine / Q000032:analysis
D000889:Anti-Arrhythmia Agents; D000120:Acecainide; D004206:Disopyramide; D011802:Quinidine; D011342:Procainamide