Current concepts of the effect of oxygen on the developing retina.
The role of oxygen in the development of retrolental fibroplasia and the mechanism of oxygen changes in the developing retina are discussed. The primary effect of oxygen is one of Vascular closure and the secondary response, which occurs after removal from increased oxygen, is retinal neovascularization. A brief discussion of recent observations on the potential role of vitamin E in the prevention of retrolental fibroplasia is presented.
D000818:Animals; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D010100:Oxygen / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects*; D012171:Retinal Vessels / Q000187:drug effects; D012178:Retinopathy of Prematurity / Q000209:etiology* / Q000517:prevention & control; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D010100:Oxygen