An immunohistochemical study of hepatoblastoma producing human chorionic gonadotropin.
High tissue concentrations of human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) were revealed by radioimmunoassay in a hepatic tumor which was surgically removed from a two-year, eight-month-old boy manifesting sexual precocity. Histologically the tumor showed an embryonal type hepatoblastoma admixed with multinucleated tumor giant cells. The localization of native hCG and hCG-beta subunit was immunohistochemically demonstrated in some of the above giant cells, while that of alpha-fetoprotein was diffusely in the tumor cells of hepatoblastoma of embryonal type. Ultrastructural features of the giant cells were also presented.
D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000601:surgery / Q000648:ultrastructure; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000601:surgery / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011863:Radioimmunoassay; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins