[Effect of diuretics on the development of experimental inflammatory edema in rats].
Experiments on rats have shown that administration of furosemide, dichlothiazide and etacrinic acid (50 mg/kg intraperitoneally) reduced the development of experimental inflammatory edema caused by subplantar administration of 0.1 ml of 6% dextran or 10% ovalbumin. The antiedematous effect of the diuretics was preserved under the conditions of bilateral nephrectomy, which points to the presence of extrarenal mechanisms in the action of the drugs in experimental inflammation.
D000818:Animals; D003911:Dextrans; D004232:Diuretics; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D004976:Ethacrynic Acid / Q000627:therapeutic use*; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D008297:Male; D010047:Ovalbumin; D051381:Rats; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*; D013997:Time Factors
D003911:Dextrans; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D005665:Furosemide; D010047:Ovalbumin; D004976:Ethacrynic Acid
Vliianie diuretikov na razvitie éksperimental'nogo vospalitel'nogo oteka u krys.