Amino acid uptake by dorsal root ganglia from streptozotocin-diabetic rats.
Dorsal root ganglia from streptozotocin-diabetic rats and age- and weight-matched control animals were incubated with 4-amino 3H-butyric acid. A significant reduction in uptake was observed in the diabetic animals. The incorporation of 3H-leucine into protein was also significantly reduced but the results did not allow a conclusion as to whether this was a secondary or an independent effect. These findings are discussed in relation both to the abnormalities known to develop in diabetic rats and to the causation of human diabetic neuropathy.
D000818:Animals; D001370:Axonal Transport; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000378:metabolism*; D005727:Ganglia, Spinal / Q000378:metabolism*; D007700:Kinetics; D007930:Leucine / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001786:Blood Glucose; D009419:Nerve Tissue Proteins; D005680:gamma-Aminobutyric Acid; D007930:Leucine