title: The kinetics of methotrexate polyglutamate formation and efflux in a human breast cancer cell line (MDA.MB.436): the effect of insulin.
mesh_terms: D000970:Antineoplastic Agents; D001943:Breast Neoplasms / Q000378:metabolism*; D002460:Cell Line; D004357:Drug Synergism; D006207:Half-Life; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D007328:Insulin; D010455:Peptides; D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D008727:Methotrexate