Specific desensitization and its mechanisms.
The following discussion concerns the background of the efficiency of classical desensitization. On the basis of clinical studies and reflections the author strives to bolster his own theory on the induction of immunological tolerance on a consequence of the immunotherapy. He presents other different hypotheses of the classical desensitization therapy. In the second part of the review, the author discusses other methods of the immunotherapy with the aid of manipulated and conjugated allergens, the application of allergen-muramylpeptides of allergen mycoloilmuramylpeptides conjugates, of allergen-pullulan compounds, of conjugates of hapten and hydrophylic polymers. The urea denaturod antigens, the allergoids, etc. etc., also belong to this group. These compounds respectively, conjugates to either suppress the T-helper lymphocytes and/or stimulate the T-suppressor cells. At the end of this review, the author reports on his own experiment on specific immunosuppression with the aid of high hot labelled allergens. He and his group have indeed, in this way, suppressed specifically the synthesis of antibodies as well as the clonal expansion of T-lymphocytes.
D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D001491:Basophils / Q000276:immunology; D003888:Desensitization, Immunologic; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000628:therapy; D007108:Immune Tolerance; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D009297:Nasal Mucosa / Q000276:immunology
D000485:Allergens; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins