title: An abnormal fibrinogen (Copenhagen II) with increased sialic acid content associated with thrombotic tendency and normal liver function.
abstract: An increased sialic acid content of the fibrinogen molecule is found in foetal fibrinogen and as an acquired disorder in hepatic disease. A qualitatively abnormal fibrinogen was detected in the plasma of a 25-year-old man with a thrombotic tendency. The purified fibrinogen had a significantly increased content of sialic acid, an abnormal fibrin monomer polymerization, and a changed mobility in crossed affinity-immunoelectrophoresis using immobilized helix pomatia lectin. The patient had no biochemical or clinical signs of liver disease. The occurrence of a thrombotic tendency and an increased fibrinogen sialic acid content without signs of liver disease may represent a new variant of congenital dysfibrinogenaemia.
mesh_terms: D000328:Adult; D005340:Fibrinogen / Q000032:analysis*; D015241:Fibrinogens, Abnormal; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D019158:N-Acetylneuraminic Acid; D009404:Nephrotic Syndrome / Q000209:etiology; D012082:Renal Veins; D012794:Sialic Acids / Q000032:analysis*; D013927:Thrombosis / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D014859:Warfarin / Q000627:therapeutic use; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D015241:Fibrinogens, Abnormal; D006242:Haptoglobins; D012794:Sialic Acids; D000511:alpha-Macroglobulins; C042326:fibrinogen Copenhagen II; D014859:Warfarin; D005340:Fibrinogen; D019158:N-Acetylneuraminic Acid