Consideration of dose levels for delayed neurotoxicity testing in hens: the relationship of neurotoxic dosages to acute LD50 values.
The oral LD50 of a compound in hens does not reliably predict the neurotoxic dose of that compound. The oral LD50 in rats does not predict either the oral LD50 in hens or the neurotoxic dose in hens, so there is no justification for using the rat value to predict the neurotoxic dosage in hens. A strategy is presented for a stepwise approach to neurotoxicity testing in hens.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D004390:Chlorpyrifos / Q000633:toxicity; D007306:Insecticides / Q000633:toxicity*; D007531:Isoflurophate / Q000633:toxicity; D010773:Leptophos / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009420:Nervous System / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D063086:Organothiophosphates / Q000633:toxicity; D009946:Organothiophosphorus Compounds / Q000633:toxicity; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester / Q000633:toxicity; D011379:Prognosis; D051381:Rats; D014468:Umbelliferones / Q000633:toxicity
D007306:Insecticides; D009943:Organophosphorus Compounds; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D014468:Umbelliferones; D007531:Isoflurophate; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; C004372:trichloronate; C006863:butyl phosphorotrithioate; D010773:Leptophos; D004390:Chlorpyrifos; C015342:merphos; C007902:haloxon