Biochemical toxicology of lindane and its analogs.
The inhibitory potencies of BHC isomers against Na+-K+- ATPase, yeast growth and nerve conduction of the American cockroach were determined. The insecticidal and neuroexcitatory activities of a number of analogs with the same configuration as lindane in which some chlorine atoms had been replaced by other substituents were also examined against American cockroaches. The structure-activity relationships and the mode of action of lindane and its analogs were discussed. Their metabolic fate was studied extensively in vivo as well as in vitro. The critical step in the biodegradation of lindane is the cleavage of C-H bonds which we found by utilizing the isotope effect of hexadeuterated lindane.
D000818:Animals; D001673:Biodegradation, Environmental; D001921:Brain / Q000201:enzymology; D002219:Carbamates; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009033:Culicidae; D003634:DDT / Q000494:pharmacology; D001556:Hexachlorocyclohexane / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D006793:Houseflies / Q000378:metabolism; D007306:Insecticides / Q000494:pharmacology; D008387:Marine Toxins / Q000494:pharmacology; D008968:Molecular Conformation; D009431:Neural Conduction / Q000187:drug effects; D010526:Periplaneta / Q000502:physiology; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D015003:Yeasts / Q000187:drug effects / Q000254:growth & development
D002219:Carbamates; D007306:Insecticides; D008387:Marine Toxins; C025633:nereistoxin; D001556:Hexachlorocyclohexane; D003634:DDT; D000254:Sodium-Potassium-Exchanging ATPase