The effects of cysteamine and capsaicin on somatostatin and substance P in medullary nuclei.
Administration of the thiol reagent, cysteamine, reduced the somatostatin content (70-80%) in each of the discrete medullary nuclei assayed without altering the substance P content of the same nuclei. In contrast, capsaicin, the putative neurotoxin for primary sensory afferent neurons had no effect on the somatostatin content of any of the medullary nuclei assayed while depleting the substance P content of the spinal trigeminal nucleus in the same animals.
D000818:Animals; D000831:Animals, Newborn; D002211:Capsaicin / Q000494:pharmacology*; D003543:Cysteamine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
D013373:Substance P; D013004:Somatostatin; D003543:Cysteamine; D002211:Capsaicin