title: Steroidal derivatives. Part 4: Synthesis and in vitro anabolic and catabolic properties of a new group of steroidal alkylating agents.
abstract: A new group of steroidal alkylating agents has been synthesized for potential anticancer activity. The compounds contain a sulfonic ester, a mono- or a bifunctional nitrogen mustard function attached to an ethyl chain and forming ether linkages at the 3- or 17 beta-position of the steroids selected. The products were tested for their in vitro anabolic and catabolic properties by measuring their effects on the bovine pancreatic ribonuclease.
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045930:Anabolic Agents / Q000138:chemical synthesis; D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D008660:Metabolism / Q000187:drug effects; D012313:RNA / Q000378:metabolism; D012259:Ribonuclease, Pancreatic / Q000378:metabolism; D013256:Steroids / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000477:Alkylating Agents; D045930:Anabolic Agents; D013256:Steroids; D012313:RNA; D012259:Ribonuclease, Pancreatic