Somatostatin-induced histamine release in mast cell incubates from thymusaplastic nude rats.
Both cyclic and linear somatostatin-14 are potent histamine secretagogues in rat mast cell incubates. Linear somatostatin-14 is more effective than cyclic somatostatin-14 in a concentration range up to 10(-6) mol/l, in normal Sprague-Dawley rats, and even more responsive in sensitized hooded Lister rats. This additional mast cell stimulation capacity of linear somatostatin-14 depends on circulating IgE levels. No differences are observed in athymic rat mast cell incubates between the linear and the cyclic isomer of somatostatin-14. A direct unspecific interaction of linear somatostatin with cell surface antibodies can be concluded.
D000818:Animals; D004062:DiGeorge Syndrome / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*
D007073:Immunoglobulin E; D013004:Somatostatin