[Potentiation of an anti-arrhythmia action by the combined use of mexiletine and propranolol].
The anti-arrhythmic effectiveness of an oral treatment schedule combining three times 200 mg mexiletine and three times 20 mg propranolol daily was compared with each drug given alone in 14 patients with stable or reproducible ventricular extrasystoles of various aetiologies, randomly divided into two groups for different therapy sequences. After each treatment phase the results and any changes in cardiac status were compared by analysing resting, exercise and long-term ECG records. Definite success of treatment with the combined drugs was obtained in nine patients with ventricular premature systoles (VPS) and in all patients with coupled VPS. A favourable influence on bigeminal and exercise-induced arrhythmias was also demonstrated. There was a significant difference in the frequency of ectopic beats between treatment with mexiletine alone or in combination with propranolol as regards the frequency of ventricular and exercise-induced premature systoles.
D000368:Aged; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D004341:Drug Evaluation; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000008:administration & dosage*; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage*; D011437:Propylamines / Q000008:administration & dosage*; D013997:Time Factors
D011437:Propylamines; D008801:Mexiletine; D011433:Propranolol
Antiarrhythmische Wirkungsverstärkung durch kombinierte Anwendung von Mexiletin und Propranolol.