[Prevention of thrombosis by Hemoclar. Preliminary results of a test in a patient with antithrombin III deficiency].
We report here preliminary results of a study comparing the effect of Hemoclar and antithrombin III (AT III) in a patient with an AT III congenital deficiency. Both drugs inhibit thrombin generation in the patient's plasma. Unlike AT III, Hemoclar also inhibits factor Xa generation. This led us to propose the use of Hemoclar, which acts via an AT III independent pathway, to prevent thrombosis in A III deficient patients.
D000328:Adult; D000990:Antithrombin III / Q000008:administration & dosage; D020152:Antithrombin III Deficiency; D001780:Blood Coagulation Tests; D005170:Factor X / Q000096:biosynthesis; D015951:Factor Xa; D005260:Female; D006801:Humans; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D013917:Thrombin / Q000096:biosynthesis; D013924:Thrombophlebitis / Q000175:diagnosis / Q000517:prevention & control*
D011134:Polysaccharides; D010426:Pentosan Sulfuric Polyester; D000990:Antithrombin III; D005170:Factor X; D013917:Thrombin; D015951:Factor Xa
Prévention des thromboses par l'Hémoclar. Résultats préliminaires d'un essai chez une malade atteinte de déficit en antithrombine III.