Relationship between the secretor status and the expression of ABH blood group antigenic determinants in human intestinal brush-border membrane hydrolases.
At least six hydrolases of the human intestinal brush-border membrane bear ABH blood group antigenic determinants related to the erythrocyte phenotype: the intestinal glycoproteins of blood group A and B subjects express A or B determinants, respectively, while blood group O subjects express the H determinant identified with Ulex europaeus lectin I. These expressions are under the control of the secretor gene: ABH antigens were not detected in the hydrolases of non-secretor subjects.
D000017:ABO Blood-Group System / Q000235:genetics; D000328:Adult; D000939:Epitopes / Q000235:genetics*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D006867:Hydrolases / Q000235:genetics* / Q000276:immunology; D007082:Ileum / Q000201:enzymology*; D007128:Immunoglobulin Fragments / Q000235:genetics*; D007413:Intestinal Mucosa / Q000201:enzymology*; D007983:Lewis Blood Group Antigens / Q000235:genetics; D008871:Microvilli / Q000201:enzymology*; D010641:Phenotype; D012635:Secretory Component / Q000235:genetics*
D000017:ABO Blood-Group System; D000939:Epitopes; D007128:Immunoglobulin Fragments; D007983:Lewis Blood Group Antigens; D012635:Secretory Component; D006867:Hydrolases