Action of lysosomotropic amines on spontaneous and interferon enhanced NK and CTL cytolysis.
Cell-mediated cytotoxicities, such as natural killer (NK) and T-dependent cytotoxic (CTL) activities, are inhibited to the same extent by lysosomotropic amines, even when interferon is added to cultures to enhance lysis. It is postulated that the amines block steps common to spontaneous and IFN-enhanced NK and CTL lytic mechanisms.
D000328:Adult; D000588:Amines / Q000494:pharmacology*; D000643:Ammonium Chloride / Q000494:pharmacology; D002103:Cadaverine / Q000031:analogs & derivatives / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008247:Lysosomes / Q000187:drug effects; D008744:Methylamines / Q000494:pharmacology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology
D000588:Amines; D008744:Methylamines; D000643:Ammonium Chloride; D002738:Chloroquine; D007372:Interferons; C008542:monodansylcadaverine; D002103:Cadaverine