Normal mitotic reactivity of fibroblasts and mesothelial cells in thrombocytopenic rat.
Mitotic reactivity following 48/80-induced mast-cell secretion was studied in the mesentery of rats made thrombocytopenic, 7 days following a single injection of melphalan. In spite of a low platelet count (7% of normal), the mitogenic reaction of the mesenteric fibroblasts and mesothelial cells was normal as judged by DNA-synthesis and mitotic index. The findings suggest that platelets and platelet-growth factors are not essential for the mast-cell-mediated mitogenic reaction of these two types of connective-tissue cells studied in vivo.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts / Q000473:pathology*; D006636:Histamine Release; D008297:Male; D008558:Melphalan; D008643:Mesentery / Q000473:pathology*; D008938:Mitosis; D008940:Mitotic Index; D051381:Rats; D013921:Thrombocytopenia / Q000139:chemically induced / Q000473:pathology*
D004247:DNA; D008558:Melphalan