Regional studies of myelin proteins in human brain and spinal cord.
The myelin specific proteins, myelin basic protein (MBP) and myelin proteolipid protein (PLP) were quantitated by radioimmunoassay (RIA) and the activity of the enzyme 2',3'-cyclic 3' phosphohydrolase (CNP) measured, in 27 regions of normal brain and spinal cord. Varying regional concentrations for each protein and regional variations for protein ratios were noted, supporting the concept of a varying chemical composition for myelin throughout the central nervous system (CNS). Variation was also noted among myelin subfractions from a single region. Regions with special sensitivity to the multiple sclerosis process had relatively lower proportions of CNP in several, but not all cases.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000032:analysis*; D000328:Adult; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry; D006801:Humans; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000032:analysis*; D009185:Myelin Proteins / Q000032:analysis*; D018991:Myelin Proteolipid Protein; D010727:Phosphoric Diester Hydrolases / Q000032:analysis*; D011863:Radioimmunoassay / Q000379:methods; D013116:Spinal Cord / Q000032:analysis* / Q000201:enzymology; D014018:Tissue Distribution
D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases