Changes in the pulmonary DNA, RNA and protein levels by semicarbazide in the perinatal and adult life of the rat.
Semicarbazide, injected intraperitoneally in a single dose of 100 mg/kg, reduced the nucleic acid and protein content in the lung of the adult and pregnant rats. The descendant of treated mothers on day 10 of gestation showed a significant decrease of DNA, RNA and protein levels in the lung when these foetuses were 21 days old, as well as during the first week of life in the protein levels.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D012663:Semicarbazides / Q000494:pharmacology*
D011506:Proteins; D012663:Semicarbazides; C010059:carbamylhydrazine; D012313:RNA; D004247:DNA