Chlordecone neurotoxicity: a brief overview.
Chlordecone or Kepone is a polycyclic chlorinated hydrocarbon insecticide that produces hyperexcitability, tremor, and other signs of nervous system toxicity. In addition, chlordecone has estrogenic-like effects and disturbs neuroendocrine function. Studies at the neurochemical level indicate that chlordecone inhibits neurotransmitter uptake; steady-state levels of biogenic amines are generally resistant to chlordecone, especially in mice. At the subcellular level, chlordecone may destabilize membrane function by altering energy metabolism and/or the disposition of ions required for neural transmission.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007631:Chlordecone / Q000633:toxicity*; D004702:Endocrine Glands / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D006801:Humans; D007306:Insecticides / Q000633:toxicity*; D009422:Nervous System Diseases / Q000139:chemically induced*; D018377:Neurotransmitter Agents / Q000502:physiology; D013045:Species Specificity; D013347:Subcellular Fractions / Q000187:drug effects
D007306:Insecticides; D018377:Neurotransmitter Agents; D007631:Chlordecone