Value of some leukocyte cytoenzymochemical investigations in detecting the noxious effects of the vinyl chloride monomer or polymer.
A group of 100 workers exposed to vinyl chloride (VC) (mean duration of exposure-13.2 years) were subjected to a complex medical examination for the detection of eventual alterations of the biologic parameters, induced by occupational exposure. Leukocyte cytoenzymochemical determinations (lymphocytic RNA--Plenert's method modified by Micu and glycogen--Hotchkiss McManus method), which might give some information on two important metabolic processes--of proteins and of carbohydrates--were performed in peripheral blood smears. Lymphocytic nucleologram and the relative and absolute nucleolar area showed an increase of endolymphocytic RNA, due to the high percentage of binucleolated cells and of spherical macronucleoli. The increase of the endolymphocytic glycogen score in parallel with the duration exposure was in correlation with high titers of serum gamma GT.
D000328:Adult; D002908:Chronic Disease; D005260:Female; D006003:Glycogen / Q000032:analysis; D006801:Humans; D008214:Lymphocytes / Q000032:analysis; D008297:Male; D009784:Occupational Diseases; D012313:RNA / Q000032:analysis; D013921:Thrombocytopenia / Q000209:etiology; D014752:Vinyl Chloride / Q000506:poisoning*; D014753:Vinyl Compounds / Q000506:poisoning*
D014753:Vinyl Compounds; D012313:RNA; D006003:Glycogen; D014752:Vinyl Chloride