Quercetin inhibits the action of 12-O-tetradecanoylphorbol-13-acetate, a tumor promoter.
Quercetin, a mutagenic but noncarcinogenic flavonoid, inhibited the increased incorporation of inorganic phosphate into phospholipids of human embryo fibroblasts induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter. Quercetin also inhibited TPA-induced increases of sugar transport and RNA synthesis in chick embryo fibroblasts, and TPA-induced aggregation of human platelets. These results suggest that quercetin may have antitumor promoter activity, which provides a possible reason why quercetin does not develop malignant tumors despite its mutagenicity.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D003847:Deoxyglucose / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004622:Embryo, Mammalian; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D010704:Phorbols / Q000037:antagonists & inhibitors*; D010710:Phosphates / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors*
D005419:Flavonoids; D010704:Phorbols; D010710:Phosphates; D010743:Phospholipids; D012313:RNA; D003847:Deoxyglucose; D011794:Quercetin; D013755:Tetradecanoylphorbol Acetate; D004121:Dimethyl Sulfoxide