title: [Morphological and histochemical study of the action of a native Clostridium perfringens type A enterotoxin on a model of the ligated ileal loop in the rabbit].
abstract: Morphological studies carried out in the igated loop of the rabbit small intestine, used as a model, have revealed that the action of the enterotoxins of C. perfringens type A reference strain and C. perfringens type A strains isolated in the USSR on the intestinal mucosa is absolutely identical. This action is manifested by the destruction of epithelial cells on the tops of the villi, inflammatory infiltration and considerable exudation of fluid into the lumen of the intestinal loop. Early lesions of the brush border of enterocytes, accompanied by the loss of alkaline phosphatase activity and the disappearance of the glycocalix, have-been histochemically established. C. perfrinegens antienterotoxic serum has proved to be capable of completely neutralizing the histopathological activity of C. perfringens enterotoxin.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D003016:Clostridium perfringens; D004305:Dose-Response Relationship, Drug; D004768:Enterotoxins / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D006651:Histocytochemistry; D007082:Ileum / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008026:Ligation; D012313:RNA / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
chemical_list: D004768:Enterotoxins; C035598:enterotoxin, Clostridium; D012313:RNA; D000469:Alkaline Phosphatase
vernacular_title: Morfologicheskoe i gistokhimicheskoe izuchenie deĭstviia nativnogo énterotokisnia Clostridium perfringens tipa A na modeli pereviazannoĭ petli podvzdoshnoĭ kishki krolika.