Serotonin in the control of the sleep-like states in frogs.
It has been established that brain serotonin (5-HT) is involved in the control of behavioral phenomena in amphibians. The transition of frogs from active wakefulness to sleep-like states was accompanied by alteration of brain 5-HT metabolism, i.e., in sleep-like state with plastic muscle tone 5-hydroxyindoleacetic acid (5-HIAA) level was reduced and in sleep-like state with rigid muscle tone both brain 5-HIAA and 5-HT were decreased. An experimental decrease of brain 5-HT level by inhibition of its biosynthesis by p-chlorophenylalanine (200 mg/kg) induced the sleep-like state of catatonic type, i.e., the state which was characterized by lowered brain 5-HT.
D000818:Animals; D001923:Brain Chemistry; D004562:Electrocardiography; D004569:Electroencephalography; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D009129:Muscle Tonus / Q000187:drug effects; D011896:Rana temporaria; D012701:Serotonin / Q000502:physiology*; D012890:Sleep / Q000502:physiology*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010134:Fenclonine