[Action of indoprofen on atrio-ventricular conduction. Preliminary note].
The purpose of the present study was to evaluate the possible electrophysiological effects of Indoprophene, a new non steroidal analgesic anti-inflammatory agent, which might be employed in the treatment of chest-pain from myocardial ischemia. Ten patient, who were undergoing a electrophysiological study for diagnostic purposes, were given 400 mg of indoprophene by intravenous rapid bolus. The A-V conduction times were recorded in basic condition and 30 minutes after administration of the drug. The data we collected show that Indoprophene does not influences either normal or prolonged A-V conduction times. We conclude that the drug, as it has a good effect on pain and lacks haemodynamic consequences and effects on conduction and excitability, is recommendable for the treatment of chest-pain from myocardial ischemia.
D000368:Aged; D001283:Atrioventricular Node / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy; D004553:Electric Conductivity; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D007216:Indoprofen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010666:Phenylpropionates / Q000627:therapeutic use*
D010666:Phenylpropionates; D007216:Indoprofen
Azione dell'indoprofene sulla conduzione atrio-ventricolare. Note preliminari.