[Serotonin participation in the mechanism of the cytoprotective action of polyglucin on the stomach].
Experiments on rats with the use of ultrastructural analysis and fluorescent-histochemical and biochemical methods have shown serotonin to participate in the mechanism of the cytoprotective effect of polyglucin on the stomach. In the presence of experimental hyperthyrosis, intravenous injection of polyglucin coupled with hydrocortisone reduces the percentage of gastric mucosa lesions. This is a consequence of the restriction of serotonin release from serotonin-producing gastric cells.
D000818:Animals; D003911:Dextrans / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000032:analysis; D006854:Hydrocortisone / Q000494:pharmacology; D006980:Hyperthyroidism / Q000150:complications; D008297:Male; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000502:physiology*; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000139:chemically induced
D003911:Dextrans; D012701:Serotonin; D006854:Hydrocortisone
Uchastie serotonina v mekhanizme tsitoprotektornogo deĭstviia poligliukina na zheludok.