Myelin-associated glycoprotein in human retina.
The human retina is unmyelinated, but structural similarities have been noted between Müller cells, the main glial cell type of retina, and oligodendrocytes, the myelin-forming cells of the central nervous system. We now show that antibodies against myelin-associated glycoprotein, a minor component of central and peripheral myelin so far found only in myelin and myelin-forming cells, also stain Müller cells. Immunoblot analysis of retinal proteins indicates that the antigen detected is myelin associated glycoprotein. These results suggest a closer relationship between Müller cells and oligodendrocytes than previously suspected and raise questions about the functional role of myelin-associated glycoprotein.
D000911:Antibodies, Monoclonal; D005865:Gestational Age; D006801:Humans; D008970:Molecular Weight; D009185:Myelin Proteins / Q000032:analysis* / Q000276:immunology; D018992:Myelin-Associated Glycoprotein; D009457:Neuroglia / Q000032:analysis* / Q000166:cytology; D012160:Retina / Q000032:analysis* / Q000166:cytology
D000911:Antibodies, Monoclonal; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein