[Detection of antigenic determinants of the major structural proteins of various mammalian type C retroviruses in the leukocytes of patients with hemoblastoses and in healthy donors by the ELISA method].
Using the enzyme-labelled antibodies it was shown that extracts from leukocytes of patients with leukemias and healthy donors contain antigenic determinants related to major virus protein of mammalian C type oncornaviruses SSV/SSAV, BaEV, FeLV and RLV. The highest antigen activity in patients was detected in the feline leukemia (FeLV) system, and the least one--in the system of murine leukemia (RLV). Common antigenic determinants of major virus protein of the viruses under study were detected in all groups of patients with haemoblastoses and healthy donors, but the amount of positive results was considerably higher in the group of patients as compared to that in the group of donors.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D002415:Cats; D002427:Cebidae / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000032:analysis*; D006801:Humans; D007938:Leukemia / Q000276:immunology* / Q000382:microbiology; D005256:Leukemia Virus, Feline / Q000276:immunology; D007962:Leukocytes / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D010215:Papio / Q000382:microbiology; D011925:Rauscher Virus / Q000276:immunology; D012190:Retroviridae / Q000276:immunology*; D012192:Retroviridae Infections / Q000276:immunology; D013045:Species Specificity; D014764:Viral Proteins / Q000276:immunology*; D015678:Viral Structural Proteins
D000956:Antigens, Viral; D000939:Epitopes; D014764:Viral Proteins; D015678:Viral Structural Proteins
Opredelenie antigennykh determinant osnovnykh virusnykh belkov nekotorykh retrovirusov tipa C mlekopitaiushchikh v leĭkotsitakh bol'nykh gemoblastozami i zdorovykh liudeĭ metodom ELISA.