Subtypes of HLA-B27 detected by cytotoxic T lymphocytes and their role in self-recognition.
In the present study cytotoxic T lymphocytes were generated in MLC of lymphocytes from two unrelated HLA-A, B, C-identical, B27-positive, but D/DR-different, individuals. These CTL were shown to detect subtypes of HLA-B27. CTL specific for influenza virus lysed infected target cells matched for HLA-B27 only when they shared the same subtype. This indicates that the two subtypes of HLA-B27 detected by CTL function also as distinct elements in a self-restricted CTL response. Both subtypes were found among patients with ankylosing spondylitis.
D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D006680:HLA Antigens / Q000145:classification* / Q000235:genetics / Q000276:immunology; D015796:HLA-B27 Antigen; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D013167:Spondylitis, Ankylosing / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D006680:HLA Antigens; D015796:HLA-B27 Antigen