title: Inhibition by low molecular weight dextran of the blood pressure fall and the lowering of plasminogen proactivator induced by clinical dextran in the rat.
abstract: The intravenous injection into rats of dextran with a molecular weight of 1,000 (LMr dextran) in doses greater than or equal to 200 mg/kg induced rapid, but transient falls in blood pressure. Pretreatment of the rats with LMr dextran 200 mg/kg caused a partial inhibition of the profound blood pressure fall induced by the injection of clinical dextran with a molecular weight of 70,000 (HMr dextran), 40 mg/kg. In accordance with previous works (Briseid & Berstad 1981; Berstad & Briseid 1982; Berstad 1982) it was found that the intravenous injection of HMr dextran lowered the plasma levels of plasminogen proactivator (pro-PGA) and functionally active high molecular weight kininogen (HMrK). Also LMr dextran, 200 mg/kg, induced significant reductions in the mentioned parameters, but less extensive than those obtained by HMr dextran, 40 mg/kg, and pretreatment of the rats with LMr dextran inhibited the subsequent effects of HMr dextran. It is suggested that a dextran-activated plasminogen activator might be an early link in the mechanism underlying the dextran-induced state of shock in the rat.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D003911:Dextrans / Q000494:pharmacology*; D004792:Enzyme Precursors / Q000378:metabolism*; D007704:Kininogens / Q000494:pharmacology; D008297:Male; D008970:Molecular Weight; D010960:Plasminogen Activators / Q000378:metabolism*; D011288:Prekallikrein / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D003911:Dextrans; D004792:Enzyme Precursors; D007704:Kininogens; C011074:plasminogen proactivator; D011288:Prekallikrein; D010960:Plasminogen Activators