Further advances in the management of malignant teratomas of the testis and other sites.
Between 1979 and 1982, 69 men with metastatic malignant teratoma completed sequential combination chemotherapy (POMB/ACE). Although two-thirds of these patients initially had advanced and bulky disease, life-table analysis projects a survival of 83%. Multivariate analysis indicates that the strongest predictor of survivals is not the clinical and radiological extent of disease but the initial serum concentration of human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP). In patients presenting with HCG levels below 50 000 IU/l and AFP levels below 500 kU/l the survival in 47 patients was 96%. This contrasts with the survival projected at 56% in 22 patients presenting with tumour markers at higher concentrations.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols; D001761:Bleomycin / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000097:blood; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine; D003609:Dactinomycin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005047:Etoposide / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008479:Mediastinal Neoplasms / Q000097:blood / Q000188:drug therapy / Q000401:mortality; D008727:Methotrexate / Q000627:therapeutic use; D009367:Neoplasm Staging; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000097:blood / Q000188:drug therapy / Q000401:mortality; D013724:Teratoma / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D013736:Testicular Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D014750:Vincristine / Q000627:therapeutic use; D000509:alpha-Fetoproteins / Q000097:blood
D000970:Antineoplastic Agents; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D003561:Cytarabine; D001761:Bleomycin; D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D008727:Methotrexate