The location of antigenic sites on the surface of the nematode parasite Strongyloides ratti reactive to antibody-directed cellular cytotoxicity from both macrophages and eosinophils from the natural host.
Heat-treated and untreated sera from rats immune to Strongyloides ratti are capable of arming both immune and non-immune macrophages and eosinophils in vitro. These cells are capable of killing larvae of the parasite. Electron microscopy has indicated multi-point attachment of the cells to the epicuticular transverse grooves of the larvae within 4 and 24 h of incubation at 37 degrees.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001666:Binding Sites, Antibody; D004804:Eosinophils / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular; D007814:Larva / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013321:Strongyloides / Q000276:immunology*; D013322:Strongyloidiasis / Q000276:immunology*
D000939:Epitopes