Changes in CSF blood-brain barrier parameters in ischaemic cerebral infarction.
Total CSF protein and CSF/serum albumin and alpha 2-macroglobulin ratios as indicators of a disturbed blood-brain barrier were determined in 39 cases of ischaemic cerebral infarction proved by computed tomography (CT). About 50% of the patients had a barrier disturbance, whereat the CSF serum albumin ratio was shown to be the most sensitive parameter. A disturbed blood-brain barrier was more often found in cases of large infarction, as shown by CT, and occurred most frequently in the first 2 weeks of illness. No correlation was seen between enhancement in CT and disturbance of the blood-brain barrier.
D001812:Blood-Brain Barrier; D002545:Brain Ischemia / Q000097:blood; D002544:Cerebral Infarction / Q000097:blood / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging; D002556:Cerebrospinal Fluid Proteins / Q000378:metabolism; D006801:Humans; D012709:Serum Albumin / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D000511:alpha-Macroglobulins / Q000378:metabolism
D002556:Cerebrospinal Fluid Proteins; D012709:Serum Albumin; D000511:alpha-Macroglobulins