Activation of intracisternal a particles by 5-azacytidine in mouse Ki-BALB cell line.
5-Azacytidine activates the production of intracisternal A particles (IAPs) in mouse Ki-BALB cell line as ascertained by electron microscopy scanning and numeration. Efficiency of the activation is higher than that obtained with iododeoxyuridine. The increase in particle production is concentration and time dependent. The results obtained in our system correlate the high IAP expression after drug treatment with a demethylation of IAP-related genes sequences.
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D004279:DNA, Viral / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007065:Idoxuridine / Q000494:pharmacology; D007708:Kirsten murine sarcoma virus / Q000502:physiology; D008745:Methylation; D051379:Mice; D012190:Retroviridae / Q000254:growth & development*; D013997:Time Factors; D014775:Virus Activation / Q000187:drug effects*
D004279:DNA, Viral; D007065:Idoxuridine; D001374:Azacitidine