title: Correlation between substance P content of primary sensory neurones and pain sensitivity in rats exposed to antibodies to nerve growth factor.
abstract: An experimental autoimmune model was used to study effects of nerve growth factor deprivation on the peptide content of sensory neurones and on pain sensitivity. Rats exposed during development to anti-nerve growth factor antibodies showed an increased threshold towards nociceptive stimuli. These animals also showed a significant decrease in substance P levels in their dorsal root ganglia and spinal cord. These results suggest that substance P-containing primary sensory neurones are involved in certain types of nociception.
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D005260:Female; D005727:Ganglia, Spinal / Q000032:analysis; D009414:Nerve Growth Factors / Q000276:immunology / Q000502:physiology*; D009475:Neurons, Afferent / Q000032:analysis*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds; D013116:Spinal Cord / Q000032:analysis; D013373:Substance P / Q000032:analysis* / Q000502:physiology
chemical_list: D001323:Autoantibodies; D009414:Nerve Growth Factors; D013373:Substance P