title: Neuroendocrine aspects of the relief of melancholia by induced seizures (electroconvulsive treatment).
abstract: Some important features of the antidepressant efficacy of ECT are described. Two principal hypotheses of this action, a neuroendocrine and a neurohumoral, are discussed in detail. The merits of the neuroendocrine hypothesis of convulsive therapy for studies of melancholia, catatonia, and new antidepressant treatments are discussed.
mesh_terms: D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002389:Catatonia / Q000628:therapy; D003480:Cushing Syndrome / Q000503:physiopathology; D003866:Depressive Disorder / Q000503:physiopathology / Q000628:therapy*; D004565:Electroconvulsive Therapy; D004702:Endocrine Glands / Q000503:physiopathology*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007031:Hypothalamus / Q000503:physiopathology; D013961:Thyroid Gland / Q000503:physiopathology
chemical_list: D001679:Biogenic Amines; D006897:Hydroxyindoleacetic Acid; D006854:Hydrocortisone; D006719:Homovanillic Acid