title: [Prognosis and determination of the threshold of chronic effect of carbon disulfide and styrene].
abstract: Two series of studies were carried out: I--in workers exposed to four different mean annual CS2 concentrations--6 mg/m3; 12 mg/m3; 51 mg/m3 and 247 mg/m3 and II series-in workers exposed to three styrene concentrations--I mg/m3; 40 mg/m3 and 400 mg/m3. The results obtained in series I show the role of the primary toxic effect (inhibition of oxidases with mixed function) and of the adaptation reactions to it with a view to accurate specifying the threshold of chronic CS2 effect. The mathematical expression of the correlation between styrene concentration in air and blood, of phenyl-glyoxylic and mandelic acid in the urine of the exposed subjects enables the prognosis that the threshold of the noxious styrene effect is within the range of 150 mg/m3 to 250 mg/m3. A reduction on CS2 MAC is proposed--from 10 mg/m3 to I mg/m3 and the correction of styrene MAC--from 5 mg/m3 to 30-50 mg/m3.
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D002246:Carbon Disulfide / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008111:Liver Function Tests; D008297:Male; D008333:Mandelic Acids / Q000652:urine; D008452:Maximum Allowable Concentration; D008875:Middle Aged; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D008995:Monoamine Oxidase / Q000097:blood; D010658:Phenylglyoxal / Q000652:urine; D013343:Styrenes / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D008333:Mandelic Acids; D013343:Styrenes; D006897:Hydroxyindoleacetic Acid; D006899:Mixed Function Oxygenases; D008995:Monoamine Oxidase; D010658:Phenylglyoxal; D002246:Carbon Disulfide
vernacular_title: Prognozirane i utochniavane praga na khronichnoto toksichno deĭstvie na serovugleroda i stirola.