title: Effect of photic injury on the retinal tissues.
abstract: In order to study the tissue damages in photic injury of the retina, the macula and posterior pole of the rhesus monkey were exposed to the light of an indirect ophthalmoscope. During the acute phase of the injury, disruption of the blood-retinal barrier appeared to be an early and sensitive indicator of retinal pigment epithelial damage and cyclic-GMP-phosphodiesterase of the photoreceptor lamella was inactivated. These lesions were followed for 2 to 5 years. Focal chronic decompensation of the blood-retinal barrier and subretinal pigment epithelial neovascularization were noted in the chronic degenerative phase of this photic maculopathy. A possible protective role of ascorbic acid in mild photic injury was proposed.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000032:analysis; D000818:Animals; D008027:Light / Q000009:adverse effects*; D008253:Macaca mulatta; D008854:Microscopy, Electron; D009389:Neovascularization, Pathologic / Q000209:etiology; D009887:Ophthalmoscopy; D010857:Pigment Epithelium of Eye / Q000201:enzymology / Q000528:radiation effects* / Q000648:ultrastructure; D051381:Rats; D012160:Retina / Q000528:radiation effects*; D012164:Retinal Diseases / Q000209:etiology; D012171:Retinal Vessels / Q000503:physiopathology
chemical_list: D015105:3',5'-Cyclic-AMP Phosphodiesterases