Erythrocyte survival and haematocrit values in rats after i.v. application of ethyl palmitate and methyl palmitate emulsions.
In the experiments on rats the effect of repeated application of ethyl palmitate emulsion (EP) and methyl palmitate emulsion (MP) on the survival rate of51Cr labelled erythrocytes and haematocrit values of the peripheral blood was studied. EP was applied in a total amount of 0.8 g, while MP due to its higher toxicity in a dose of 0.4 g per 100 g of body weight. The application of EP caused mild, though significant shortening of the survival period of the erythrocytes; the haematocrit values remained unchanged. Following application of MP no differences as compared to control animals could be found.
D000818:Animals; D004905:Erythrocyte Aging / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D006400:Hematocrit; D008297:Male; D010168:Palmitates / Q000008:administration & dosage / Q000494:pharmacology*; D010169:Palmitic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005217:Fat Emulsions, Intravenous; D010168:Palmitates; D010169:Palmitic Acids; C019012:methyl palmitate; C007680:ethyl palmitate