Thy-1 epitopes are expressed on murine myeloid leukemia and reticulum sarcoma cells.
Expression of Thy-1.2 specificities in cells from 29 primary spontaneous leukemias of random-bred ICR Swiss mice was examined by cell membrane and cytoplasmic immunofluorescence with monoclonal HO-13-4 antibody [1]. The Thy-1.2 epitopes were detected in all thymic lymphomas and were absent in the lymphomas of non-thymic origin. Unexpectedly, the Thy-1.2 epitopes were also detected in 71% (5/7) of myeloid leukemias and 40% (4/10) of reticulum cell sarcomas examined.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D003593:Cytoplasm / Q000276:immunology; D000939:Epitopes / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D007942:Leukemia, Experimental / Q000276:immunology; D007951:Leukemia, Myeloid / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology*; D051379:Mice; D008813:Mice, Inbred ICR; D012513:Sarcoma, Experimental / Q000276:immunology; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D000939:Epitopes; D018800:Thy-1 Antigens