Effect of antineoplastic drugs on fibroblast proliferation in rabbit aqueous humor.
An assay is described to test the ability of antineoplastic agents to slow fibroblast growth. The effect of bleomycin sulfate, cytosine arabinoside (cytarabine), and 5-fluorouracil on suppression of fibroblast proliferation in 20% rabbit aqueous humor was studied in vitro. All of the drugs exhibited some suppression of fibroblast proliferation at differing doses. The choice of target cell, however, was an important factor in the dose responses obtained.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001082:Aqueous Humor / Q000502:physiology*; D001761:Bleomycin / Q000494:pharmacology; D003228:Conjunctiva / Q000166:cytology; D003561:Cytarabine / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D005472:Fluorouracil / Q000494:pharmacology; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D011817:Rabbits; D012867:Skin / Q000166:cytology
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D003561:Cytarabine; D001761:Bleomycin; D005472:Fluorouracil