title: Effect of vasoactive agents on prostanoids in suction blister fluid.
abstract: Iontophoresis of histamine in the skin has been shown to release prostaglandins and arachidonic acid in suction blister fluid. Application of DMSO had a similar effect. No effect was found after using the following erythema and oedema irritants: scraping, vibration and ketocaine. Treatment with vasoconstricting drugs such as noradrenaline betamethasone and lidocaine-prilocaine mixture did not influence the prostaglandin or arachidonic acid levels.
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000032:analysis; D001768:Blister / Q000378:metabolism*; D006801:Humans; D007478:Iontophoresis; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000032:analysis*; D013396:Suction; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D001095:Arachidonic Acids; D011453:Prostaglandins; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents