The reaction of the anti-interferon-alpha monoclonal antibody, NK2, with different interferons.
Analysis of the neutralization of human interferon-alpha by the monoclonal antibody NK2 showed, by three different methods, that the avidity constant was about 10(10)M-1. A small decrease in the avidity constant (and in the antibody titre) with increasing interferon concentrations was observed, suggesting that the antibody-interferon complex had a little biological activity. The antibody neutralizes the interferon by preventing the binding of interferon to susceptible cells. It does not react with human-gamma, mouse-alpha, monkey, bovine or rabbit interferons.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D007372:Interferons / Q000276:immunology*; D009500:Neutralization Tests
D000911:Antibodies, Monoclonal; D007370:Interferon Type I; D007372:Interferons