title: [Characteristics of interferon production with different administration schedules of inducers].
abstract: The results of the study of interferon production after multiple administrations of various interferon inducers in mice are presented. Irrespective of the type of inducer, the state of refractoriness developed 2-3 days after the 1st administration of the inducer due to which repeated administrations of the inducers due to which repeated administrations of the inducers for up to 6 days did not induce significant amounts of interferon; on the contrary, a 30-fold decrease of interferon production was observed. Daily administration of the inducers for 4 and 6 times did not result in the overcoming or prolongation of the state of refractoriness. Different schedules of multiple inducer administrations were tested. Better results were obtained after administration of a double-stranded RNA at 1, 3, 6, and 8 days yielding high levels of interferon production after each administration of the inducer.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007369:Interferon Inducers / Q000008:administration & dosage*; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D007739:L Cells / Q000276:immunology; D008297:Male; D051379:Mice; D013997:Time Factors
chemical_list: D007369:Interferon Inducers; D007372:Interferons
vernacular_title: Osobennosti produktsii interferona pri raznykh skhemakh primeneniia induktorov.