Regulation of immune responses by I-J gene products. V. Heterogeneity of I-J gene products as detected by anti-I-J monoclonal antibodies.
The products of I-region genes of the murine major histocompatibility complex (H-2) are intimately involved in the regulation of immune responses. In a number of antigen systems, suppressor T (Ts) cells and their factors (TsF) bear determinants of gene(s) that map to the I-J subregion of the H-2 complex. Suppression in one such system, poly(Glu50Tyr50)(GT), involves the interaction of multiple Ts subsets. Three monoclonal I-Jk-bearing GT-TsF have been identified that functionally differ from one another. We report the binding of these monoclonal GT-TsF to different anti-I-Jk monoclonal antibody columns. We find that these anti-I-Jk monoclonal antibodies display differing degrees of efficiency of GT-TsF binding. These data suggest a greater degree of heterogeneity of I-Jk gene products than has been proposed before.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001666:Binding Sites, Antibody; D004247:DNA / Q000235:genetics; D000939:Epitopes / Q000276:immunology; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines / Q000235:genetics / Q000502:physiology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000276:immunology; D014176:Protein Biosynthesis; D013491:Suppressor Factors, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal; D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D010455:Peptides; D013491:Suppressor Factors, Immunologic; C027606:L-glutamic acid-L-tyrosine copolymer; D004247:DNA