Studies of antigens in Plasmodium yoelii. II. Inheritance and recombination of antigenic characters.
The inheritance of an antigen designated Py-1 in the rodent malaria parasite Plasmodium yoelii has been investigated. A cross was made between 2 lines differing in the electrophoretic mobility and quantity of Py-1 detected by crossed immunoelectrophoresis. In 10 clones isolated from the progeny of the cross the level of Py-1 always correlated with the virulence of the infection and it was concluded that these characters were different phenotypic effects of the same gene mutation. The electrophoretic mobility of Py-1 segregated independently of the virulence character and was therefore controlled by a different gene. These two antigenic markers also recombined with isoenzyme and drug-sensitivity characters distinguishing the parent lines.
D000818:Animals; D003433:Crosses, Genetic; D000939:Epitopes / Q000032:analysis / Q000235:genetics*; D005796:Genes; D005819:Genetic Markers; D007123:Immunoelectrophoresis, Two-Dimensional; D051379:Mice; D008810:Mice, Inbred C57BL; D010961:Plasmodium / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D011995:Recombination, Genetic; D014774:Virulence
D000939:Epitopes; D005819:Genetic Markers