The long-term influence of isoproterenol (ISO) retard tablets on the course of an acute inflammation.
Rats were exposed for 21 d to Isoproterenol (ISO) applied by subcutaneously implanted retard tablets. ISO causes a rise in the number of lymphocytes at the site of inflammation (injected sephadex) until the tenth day. The reaction of the connective tissue is moderately enhanced. The weight of the salivary glands is constantly elevated,and the weight of the hearts increases in a linear pattern until the end of the experiment. Neither in test nor in control animals is there any correlation between the number of white cells in the blood and their appearance at the site of inflammation.
D000208:Acute Disease; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003692:Delayed-Action Preparations; D003911:Dextrans / Q000633:toxicity; D006321:Heart / Q000033:anatomy & histology / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012469:Salivary Glands / Q000033:anatomy & histology / Q000187:drug effects
D003692:Delayed-Action Preparations; D003911:Dextrans; C025614:sephadex; D007545:Isoproterenol