High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP). Clinical effects.
This study of the effect of high-dose intravenous gammaglobulins with one or two courses of therapy in 18 adults with idiopathic thrombocytopenia purpura showed a platelet rise in thirteen patients. The highest response rates were seen in splenectomized adults. In chronic patients the response was transient only. If therapy was effective, increased values of platelet-associated IgG were reduced, while shortened platelet survival times were prolonged. There was no influence of high-dose gammaglobulins on platelet function. different 7S-preparations such as beta-propiolactone modified Ig, pH 4 treated Ig and reduced and alkylated Ig have comparable effects.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001780:Blood Coagulation Tests; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D011420:Propiolactone / Q000627:therapeutic use; D011696:Purpura, Thrombocytopenic / Q000628:therapy*; D013156:Splenectomy; D005719:gamma-Globulins / Q000627:therapeutic use*
D005719:gamma-Globulins; D011420:Propiolactone