title: Papillary adenocarcinomas of the prostate. An immunohistochemical study.
abstract: Five cases of papillary adenocarcinomas of the prostate were studied for prostate-specific acid phosphatase, using the immunoperoxidase method, to determine the origin and histogenesis of these uncommon tumors. All five cases were prostatic-acid-phosphatase positive, whereas four cases showed in situ carcinoma involving large periurethral ducts. Positive immunohistochemical localization of prostate-specific acid phosphatase is useful in identifying papillary carcinoma of true prostatic origin and distinguishing them from prostatic-acid-phosphatase-negative carcinomas which may include tumors arising from periurethral glands or metaplastic urethral mucosa.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis*; D000231:Adenocarcinoma, Papillary / Q000201:enzymology / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000473:pathology*; D013194:Staining and Labeling
chemical_list: D000135:Acid Phosphatase