A viral coat glycoprotein (gp52MuMTV) has detergent-sensitive and detergent-resistant epitopes in the same molecule.
Two monoclonal antibodies (IIB5 and IC12) specific for the gp52 coat glycoprotein of mouse mammary tumor virus are directed against epitopes on the gp52 that are sensitive to a non-ionic detergent, Nonidet P-40. There are other epitopes on this molecule that are stable in the detergent, as seen in immunoprecipitation studies with other anti-gp52 monoclonal antibodies (VE7, IIIA1, IVC11).
D000911:Antibodies, Monoclonal / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D003902:Detergents / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D017830:Octoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology; D014759:Viral Envelope Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D003902:Detergents; D000939:Epitopes; D014759:Viral Envelope Proteins; D011092:Polyethylene Glycols; D017830:Octoxynol; C010615:Nonidet P-40