Oncostatic properties of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79).
The oncostatic properties of C-79 preparation were examined on the mice with: sarcoma Sa-180, melanoma B-16, Ehrlich carcinoma and leukemia P-388. The preparation was observed to prolong the life of animals with sarcoma Sa-180 and to modulate the morphology of tumors in them. The preparation had no effect on three remaining investigation models. The investigations carried out on mice of AKR strain have revealed that C-79 significantly suppresses the occurrence of spontaneous leukemia, prolonging the mouse survival-time.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D003300:Copper / Q000008:administration & dosage / Q000627:therapeutic use*; D003911:Dextrans / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012510:Sarcoma 180 / Q000188:drug therapy
D000970:Antineoplastic Agents; D003911:Dextrans; C018905:dextran-2-hydroxy-3-mercaptopropyl ether; D003300:Copper