Recognition of influenza A virus nucleoprotein by an H-2-restricted cytotoxic T-cell clone.
Cytotoxic T-cell clones raised against X-31 (H3N2) influenza virus in C57BL/6 mice can be directed against an influenza A virus subtype specific determinant (1). A representative T-cell clone (A3.1) has been used in combination with a set of genetically typed recombinant viruses, to show that the A/PR/8/34 nucleoprotein can be responsible for cytotoxic T-lymphocyte recognition of infected target cells.
D000818:Animals; D002999:Clone Cells; D003001:Cloning, Molecular; D000939:Epitopes / Q000032:analysis; D005796:Genes; D005814:Genes, Viral; D006183:H-2 Antigens / Q000235:genetics*; D009980:Influenza A virus / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009698:Nucleoproteins / Q000235:genetics*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes; D006183:H-2 Antigens; D009698:Nucleoproteins