title: [Modification of the antiradical defense system of the organism under the influence of the administration of a leukocyte factor in the rabbit. Its relation to the increase of radioresistance by biostimulants].
abstract: Injection in the rabbit of the leucocyte endogenous mediator (LEM) liberated by activated granulocytes provokes after 24 h an increase in the glutathione concentration, particularly in the spleen and in the kidney, as well as an increase in acute phase proteins and modifications of the zinc concentration in the plasma, the liver and the kidney. These modifications are compared with those provoked by non specific biostimulants which increase the radioresistance during periods varying from several days to several weeks. It may be that LEM or a component accompanying it in the injected fraction is a factor intervening in the increase in radioresistance caused by biostimulants.
mesh_terms: D000818:Animals; D002056:Burns / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism*; D006098:Granulocytes / Q000378:metabolism; D006242:Haptoglobins / Q000378:metabolism; D007375:Interleukin-1; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010659:Phenylhydrazines / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D011817:Rabbits; D011836:Radiation Tolerance; D013154:Spleen / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D005609:Free Radicals; D006242:Haptoglobins; D007375:Interleukin-1; D010659:Phenylhydrazines; D011506:Proteins; C008270:leukocyte endogenous mediator; D005978:Glutathione; D015032:Zinc
vernacular_title: Modification du système de défense antiradicalaire de l'organisme sous l'influence de l'administration d'un facteur leucocytaire chez le lapin. Ses rapports avec l'accroissement de la radiorésistance par les biostimulants.