Intraocular injection of tetrodotoxin in goldfish decreases fast axonal transport of [3H]glucosamine-labeled materials in optic axons.
When physiological activity in goldfish visual system was abolished by repeated intraocular injection of tetrodotoxin (TTX), the fast axonal transport of radioactive amino acid-labeled protein in the optic axons was unaltered. However, the TTX treatment reduced the amount of [3H]glucosamine-labeled glycolipids that were axonally transported to the optic tectum, and may have decreased their rate of turnover in the tectum. A similar though smaller effect was observed for glucosamine-containing glycoproteins. These alterations in axonal transport may be the basis for at least some of the deleterious effects of TTX on axonal regeneration in this system.
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D005944:Glucosamine / Q000378:metabolism*; D006054:Goldfish; D009416:Nerve Regeneration / Q000187:drug effects; D009900:Optic Nerve / Q000187:drug effects*; D011392:Proline / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology*
D013779:Tetrodotoxin; D011392:Proline; D005944:Glucosamine