Influence of human allergic encephalitogenic peptide on platelet aggregation in multiple sclerosis.
After addition of encephalitogenic peptide to the blood of multiple sclerosis patients a factor X with platelet aggregation activating property could be demonstrated in the supernatant serum. Factor X was able to induce a platelet aggregation or to enhance an ADP-induced platelet aggregation. These findings suggest an explanation for the well-known platelet alterations found in multiple sclerosis.
D000208:Acute Disease; D000244:Adenosine Diphosphate / Q000494:pharmacology; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood*; D004676:Myelin Basic Protein / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*
D004676:Myelin Basic Protein; D000244:Adenosine Diphosphate