Studies on the role of the sex-hormone-binding globulin (SHBG) in prostatic gland hypertrophy in men. II. In vitro research.
The effect of SHBG, stilbestrol and cyproterone acetate on the amount of 3H-DHT in the cell nuclei of hypertrophic prostatic glands was studied in vitro. It was found the SHBG lowers the DHT content, whereas stilbestrol and cyproterone acetate in the presence of SHBG tends to increase the amount of 3H-DHT in the nuclei.
D000328:Adult; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D004054:Diethylstilbestrol / Q000494:pharmacology; D013196:Dihydrotestosterone / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011467:Prostate / Q000187:drug effects / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000494:pharmacology*; D013739:Testosterone / Q000378:metabolism
D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone; D017373:Cyproterone Acetate; D004054:Diethylstilbestrol; D003534:Cyproterone