Histamine level in the blood and in the lung tissue during anaphylactic reaction in guinea-pigs treated with hydrocortisone and sodium cromoglycate.
The effect of hydrocortisone and disodium cromoglycate (Intal) on histamine release during immediate allergic reaction in experimental animals was studied. Histamine level in the blood and lung tissue was determined before antigen challenge during experimental asthma and after administration of hydrocortisone or Intal. The investigations revealed some differences in the histamine content in the blood and lung tissue depending on the time of the drug administration in relation to the antigen challenge and to the period of treatment.
D000707:Anaphylaxis / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects; D006854:Hydrocortisone / Q000627:therapeutic use*; D008168:Lung / Q000378:metabolism*
D006632:Histamine; D004205:Cromolyn Sodium; D006854:Hydrocortisone