The lymphocytic reaction to blood donation in the peripheral blood of healthy blood donors.
This study was undertaken to provide more information on the lymphocytic reaction to blood loss in the peripheral blood of healthy blood donors. Number of lymphocytes as well as lymphocytic nucleolar coefficient and number of lymphocytes classified according to the presence of functionally dominant nucleoli in their nuclei were studied 10 minutes, 2 and 24 hours, 2, 4, 6, and 8 weeks after blood donation. In general, the number of these cells increased rapidly after blood donation reaching maximal values of 2-24 hours, then it slowly returned to the original values after 4-8 weeks depending on the functionally dominant nucleolar type in their nuclei. According to the presented results the lymphocytic reaction may also differ in new and repeated blood donors as well as in various seasons of the year. In contrast, no differences were observed between male and female blood donors after the first blood donation in one and the same season of the year. The values of the lymphocytic nucleolar coefficient increased after blood donation and were usually different in new and repeated blood donors. Some differences of the nucleolar coefficient were also found in various seasons of the year before as well as after blood donation.
D001782:Blood Donors; D002466:Cell Nucleolus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology* / Q000648:ultrastructure; D008297:Male; D012621:Seasons; D012737:Sex Factors; D013997:Time Factors