Capacity of a cis-diammineplatinum[II]-polyglutamic acid complex to cure Trypanosoma congolense infections in mice.
A cis-diammineplatinum(II)-polyglutamic acid complex proved to have marked trypanocidal activity in vivo. When 5 mg of platinum per kg was administered daily for 5 days or when 20 mg of platinum per kg was administered on days 1, 3, and 6, five of five treated Trypanosoma congolense-infected mice were cured. In contrast, cis-platin was ineffective at all doses tested. We believe that the complex has a much higher therapeutic ratio than does uncomplexed drug because it is less toxic.
D000818:Animals; D002945:Cisplatin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D007674:Kidney Diseases / Q000139:chemically induced; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000627:therapeutic use*; D011099:Polyglutamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000009:adverse effects / Q000138:chemical synthesis / Q000627:therapeutic use*; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D010455:Peptides; D014344:Trypanocidal Agents; C040622:cis-diammineplatinum(II)-polyglutamic acid complex; D011099:Polyglutamic Acid; D002945:Cisplatin