Enhancement of histamine synthesis in mouse skin by epinephrine.
Intravenous administration of 10-40 micrograms/Kg epinephrine to mice leads to a transient 50% increase in skin histamine, followed by an increase in blood histamine. Delayed inhibition by alpha-fluorometyl histidine (alpha FMH), suggests that these changes follow stimulation of pre-formed tissue histidine decarboxylase.
D000818:Animals; D017259:Dimaprit / Q000031:analogs & derivatives*; D004837:Epinephrine / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology; D006632:Histamine / Q000096:biosynthesis* / Q000097:blood; D006636:Histamine Release / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology; D051379:Mice; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena; D013890:Thiourea / Q000494:pharmacology
D006146:Guanidines; D008762:Methylhistidines; C024535:SK&F 91488; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D013890:Thiourea; C004479:pimagedine; D004837:Epinephrine; D017259:Dimaprit