Symmetry of effector function in the immune system network.
Symmetry in antibody plus complement mediated killing between a T15 idiotype-bearing monoclonal antibody (HPC-M2) and an anti-T15 monoclonal antibody (B36-82) is demonstrated. The HPC-M2 antibody is also shown to be multispecific in its effector function, since it lyses both phosphorylcholine coated erythrocytes, and B36-82 Fab coated red blood cells. The symmetry and multispecificity in effector function are presented as new evidence against the concept that the paratope of antibody molecule exists as a uniquely defined site on the antibody variable region. A theoretical consequence for immune system network theory is that the anti-idiotypic set and the internal image are functionally equivalent, the results support symmetric network models of regulation, and are evidence against asymmetric models.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006825:Hybridomas / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D008954:Models, Biological
D000911:Antibodies, Monoclonal; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M; D003165:Complement System Proteins