A cell membrane "gp70" associated with Fv-4 gene: immunological characterization, and tissue and strain distribution.
Fv-4r is a dominant resistance gene which controls susceptibility of mice to exogenous infection with ecotropic murine leukemia virus (MuLV). A MuLV env-gene product related to gp70 on cells from uninfected Fv-4r mice has been found. Expression of this molecule is closely linked to the resistance allele. Antigenic determinants on the Fv-4r gp70 are similar to many ecotropic and some dualtropic MuLV gp70s but different from xenotropic and amphotropic MuLV gp70s. The Fv-4r gp70 molecule also has unique antigenic determinants since it is recognized by Fv-4 specific antisera which do not recognize other cell membrane gp70s or viral gp70s. The Fv-4-specific cell membrane gp70 is detectable on cells from thymus, spleen, lymph node, bone marrow, and embryo fibroblasts from Fv-4r mice, but not from Fv-4s mice. Slight differences in electrophoretic mobility of Fv-4r gp70 are found on different tissues. This unique cell membrane gp70 may be causally related to Fv-4 resistance.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D002462:Cell Membrane / Q000276:immunology; D002471:Cell Transformation, Neoplastic; D003433:Crosses, Genetic; D004622:Embryo, Mammalian; D000939:Epitopes / Q000235:genetics; D005796:Genes; D005799:Genes, Dominant; D007113:Immunity, Innate; D009052:Leukemia Virus, Murine / Q000235:genetics; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D013045:Species Specificity; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000276:immunology; D014779:Virus Replication
D000954:Antigens, Surface; D000939:Epitopes; D014759:Viral Envelope Proteins