Ir gene control of immune responses to insulins. II. Phenotypic differences in T cell activity among nonresponder strains of mice.
Immune responses by mice to heterologous insulins are controlled by H-2 linked Ir genes. In studies to determine the mechanisms responsible for nonresponsiveness, we found that although pork insulin failed to stimulate antibody or proliferative responses in H-2b mice, it did prime T cells that can express helper activity in adoptive recipient mice. This helper activity was insulin-specific in both elicitation and expression. In studies presented in this paper, we have extended this analysis to the response patterns of helper T cells stimulated by sheep, horse, and rat insulins in mice bearing different H-2 haplotypes. The results demonstrate that nonresponder forms of insulin, including rat insulin, prime T cells in H-2b and H-2d, but not H-2k, mice. These results suggest that regulation of nonresponsiveness to insulin appears to be through different pathways in mice bearing different H-2 haplotypes.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes / Q000235:genetics; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006736:Horses; D007108:Immune Tolerance; D007328:Insulin / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D007330:Insulin Antibodies / Q000096:biosynthesis; D008213:Lymphocyte Activation; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010641:Phenotype; D051381:Rats; D012756:Sheep; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000939:Epitopes; D007328:Insulin; D007330:Insulin Antibodies