Alpha 1-microglobulin in urine as an indicator of renal tubular damage caused by environmental cadmium exposure.
Alpha1-Microglobulin (alpha 1-m) was determined in the urine of both the cadmium-exposed and nonexposed subjects and was compared with those of other urinary parameters such as beta 2-microglobulin (beta 2-m), glucose, total protein or amino acids. Large amounts of alpha 1-m were detected in the urine of cadmium-exposed subjects. There were significant correlations between alpha 1-m and other urinary parameters. The sensitivity and specificity of both alpha 1-m and beta 2-m as indices of tubular dysfunction caused by cadmium was similar. It was concluded that alpha 1-m in urine seemed to be a useful indicator of renal tubular dysfunction caused by cadmium.
D000368:Aged; D000510:Alpha-Globulins / Q000652:urine*; D002105:Cadmium Poisoning / Q000652:urine*; D003404:Creatinine / Q000652:urine; D004781:Environmental Exposure; D005260:Female; D006029:Glycosuria; D006801:Humans; D007674:Kidney Diseases / Q000652:urine*; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000652:urine
D000510:Alpha-Globulins; C016001:alpha-1-microglobulin; D001613:beta 2-Microglobulin; D003404:Creatinine