Sodium fluoride evoked histamine release from mast cells. A study of cyclic AMP levels and effects of catecholamines.
Calcium triggers the secretion of histamine from mast cells after previous exposure to sodium fluoride. The secretory process can be divided into a fluoride-activation step and a calcium-induced secretory step. It was observed that the fluoride-activation step is accompanied by an elevation of cAMP levels within the cells. The attained high levels of cAMP persist during histamine release. It was further found that catecholamines do not markedly alter the fluoride-induced histamine release. It was also confirmed that the second, but not the first, step in sodium fluoride-induced histamine secretion is inhibited by theophylline.
D000818:Animals; D002118:Calcium / Q000502:physiology; D002395:Catecholamines / Q000494:pharmacology*; D000242:Cyclic AMP / Q000032:analysis*; D005459:Fluorides / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008407:Mast Cells / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D012969:Sodium Fluoride / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D002395:Catecholamines; D003189:p-Methoxy-N-methylphenethylamine; D012969:Sodium Fluoride; D000242:Cyclic AMP; D005459:Fluorides; D002118:Calcium