Morphogenesis and pathogenesis of chronic lung diseases. XX. Effects of repeated hypersensitivity reactions upon experimental immuno-granulomas of the lung.
In order to analyse the effects of repeated hypersensitivity reactions upon chronic lung lesions, lung granulomas were experimentally induced in rabbits by an intravenous injection of 1 ml of the complete Freund's adjuvant added with 10 per cent human gammaglobulin. Groups of rabbits with 14- and 21-day-granulomas were intratracheally challenged with 1.000 I.U. human gammaglobulin injected two or three times at 7-9 days interval. The responses of the lung tissue were of the Arthus type with neutrophil granulocytic accumulations and proteasic action; the intensity of cell accumulations was decreasing after the 2nd and 3rd challenge. The lesional evolution after challenge showed intra- and perigranulomatous infiltrations with alkaline-phosphatase positive lymphocytes and plasma cells. The density of the intragranulomatous reticulin network developed after the hypersensitivity reactions increased progressively and was morphometrically assessed as statistically significant. Cellular and fibrillar lesions led to the restructuring of the lung tissue.
D000818:Animals; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006099:Granuloma / Q000209:etiology / Q000473:pathology*; D007275:Injections, Intravenous; D008171:Lung Diseases / Q000139:chemically induced / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D011817:Rabbits; D005719:gamma-Globulins / Q000008:administration & dosage
D005719:gamma-Globulins; D005620:Freund's Adjuvant