Study of the target cell of the dengue virus-induced suppressor signal.
Dengue type 2 virus (DV) induces two generations of T suppressor cells (Ts1 and Ts2) in murine spleen. The Ts2 cells produce a soluble factor ( SF2 ) which suppresses DV-specific IgM antibody plaque-forming cells (PFC). In this study the target cell of SF2 was examined. The results show that SF2 requires a third generation of T cells (T3) in order to mediate suppression. The surface phenotype of this T3 cell is Ly 1+ and the suppression mediated is antigen specific.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D002472:Cell Transformation, Viral; D003715:Dengue / Q000276:immunology*; D003716:Dengue Virus; D000939:Epitopes; D006462:Hemolytic Plaque Technique; D007075:Immunoglobulin M / Q000276:immunology; D008222:Lymphokines / Q000494:pharmacology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000276:immunology; D013491:Suppressor Factors, Immunologic; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000939:Epitopes; D007075:Immunoglobulin M; D008222:Lymphokines; D013491:Suppressor Factors, Immunologic