Factors acting upon differentiation of mouse teratoma in vivo: spontaneous differentiation and effects of interferon.
CE/44 mouse teratocarcinoma and its sublines isolated at the Institut Pasteur were studied comparatively in 129/Sv, hybrid F1 129 X NCS, and NCS strains of male and female mice with respect to the age of the animals and the type of the tumor graft (ascitic or subcutaneous solid tumor). The tumors grow more quickly and with more malignant characteristics in female mice. The tumor "takes" and growth are equally good in the hybrid F1 as in 129/Sv mice, but its maintenance in hybrid F1 is not so stable, for a tumor loss and a lessening of differentiation could be seen through the passages in this strain. In the NCS strain the tumor grows very rarely. Interferon slowed the subcutaneous tumor growth and favored neuroepithelial tissue differentiation, but allowed selective growth of one cellular type, the "trophoblastic" one, which is very malignant, and which, in the ascitic tumor, caused death in female animals by a hemorrhagic syndrome.
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001201:Ascites / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D005260:Female; D007370:Interferon Type I / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009368:Neoplasm Transplantation; D013724:Teratoma / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D000509:alpha-Fetoproteins / Q000032:analysis
D007370:Interferon Type I; D000509:alpha-Fetoproteins; D000469:Alkaline Phosphatase