Sequential administrations of polyriboinosinic acid and polyribocytidylic acid induce interferon and depress the hepatic cytochrome P-450-dependent monooxygenase system.
D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D005037:Ethylmorphine-N-Demethylase / Q000037:antagonists & inhibitors; D007369:Interferon Inducers; D007372:Interferons / Q000378:metabolism; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011066:Poly C / Q000494:pharmacology*; D011069:Poly I / Q000494:pharmacology*; D011131:Polyribonucleotides / Q000494:pharmacology*; D013997:Time Factors
D065607:Cytochrome P-450 Enzyme Inhibitors; D007369:Interferon Inducers; D011131:Polyribonucleotides; D011069:Poly I; D011066:Poly C; D007372:Interferons; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D005037:Ethylmorphine-N-Demethylase