Prenatal diagnosis of thalassaemia by haemoglobin chromatography on Biorex. An evaluation of the method.
The applicability of the chromatographic separation of haemoglobin F, A and S on Biorex 70 ( Blouquit et al., 1982) for the prenatal diagnosis of thalassaemia and related conditions was evaluated in comparison to the conventional globin chain separation technique. The method proved reliable, inexpensive and rapid and should be considered as a valuable alternative in laboratories carrying out great numbers of tests and those being newly set up for this purpose.
D002411:Cation Exchange Resins; D002852:Chromatography, Ion Exchange; D005069:Evaluation Studies as Topic; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis*; D006441:Hemoglobin A / Q000032:analysis*; D006451:Hemoglobin, Sickle / Q000032:analysis; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012117:Resins, Synthetic; D013789:Thalassemia / Q000175:diagnosis*
D002411:Cation Exchange Resins; D006451:Hemoglobin, Sickle; D012117:Resins, Synthetic; C026257:Bio-Rex 70; D006441:Hemoglobin A; D005319:Fetal Hemoglobin