Cross-protection by Pseudomonas aeruginosa polysaccharides.
High-molecular-weight polysaccharide from Pseudomonas aeruginosa immunotypes 1 and 2 gave cross-protection in outbred CD-1 mice challenged with the heterologous immunotype organism. Both active immunization with 50 micrograms of polysaccharide, as well as passive transfer of immune serum were effective. The basis for this cross-protection is the ability of high doses of polysaccharide to induce antibody formation to both homologous and heterologous immunotype determinants.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D007114:Immunization; D007116:Immunization, Passive; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000276:immunology*
D000907:Antibodies, Bacterial; D000939:Epitopes; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial