Phenotypic characterization of skin-infiltrating cells in pagetoid reticulosis by monoclonal antibodies.
The immunological characterization of the infiltrating cells in a patient with a disseminated form of Pagetoid reticulosis (PR) was carried out-in histological section and cell suspensions--by means of a panel of monoclonal antibodies and classical markers (E-rosette and surface immunoglobulins (SIg]. Most of the infiltrating cells were seen to be mature T-lymphocytes with a suppressor/cytotoxic phenotype (T11+, T3+, T8+, T4-). The results suggest that this variant of PR represents a special histological type of cutaneous T cell lymphoma.
D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000276:immunology* / Q000473:pathology; D008223:Lymphoma / Q000276:immunology; D010145:Paget Disease, Extramammary / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D012867:Skin / Q000166:cytology*; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification / Q000473:pathology*
D000911:Antibodies, Monoclonal