Allospecific suppression without requirement for participation of Ly 2+ cells.
Haplotype-specific suppressor T cells (Ts) were induced by incubation of mouse spleen/lymph node cells with allogeneic heat-treated cells. These Ts have an Ly 1+2- phenotype, and can be activated in cultures depleted of Ly 2+ cells by treatment with anti-Ly 2 antibodies and complement. In addition, these Ts inhibit alloantigen-induced proliferation of Ly 1+2- cells without the participation of Ly 2+ cells. These results show that allospecific suppressor T cells can be activated and can act without participation of Ly 2+, thus demonstrating that Ly 1+2- cells can directly suppress proliferation of other Ly 1+2- cells.
D000818:Animals; D002455:Cell Division; D003602:Cytotoxicity, Immunologic; D000939:Epitopes; D007518:Isoantibodies / Q000276:immunology; D007519:Isoantigens / Q000276:immunology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000939:Epitopes; D007518:Isoantibodies; D007519:Isoantigens; C029805:Lyt antibodies