Salivary secretion induced by substance P.
Secretion of fluid, ions, and amylase from parotid and submaxillary glands of rat, induced by intravenous injection of substance P (SP), was examined. The action of SP on salivary glands, like physalaemin, resembled that of cholinergic stimulation. While SP-evoked salivary flow from both glands was blocked by atropine, atropine did not modify composition of SP-evoked saliva. The present study suggests that salivary secretion and secretion of ions and amylase evoked by SP are mediated via SP-sensitive cholinergic receptors and specific SP receptors, respectively.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D008297:Male; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D012463:Saliva / Q000378:metabolism*; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D001285:Atropine