Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome.
The mammalian sex chromosomes are thought to be related to each other by sharing a common origin. That is, the X and Y chromosomes originally evolved from a pair of chromosomes that only differed at the locus determining sexual differentiation. For example, this evolutionary relationship is reflected during meiosis in chromosomal pairing between the tip of the human X chromosome short arm and the Y chromosome which presumably implies sequence homology. However, compelling genetic evidence for functional homology between the mammalian X and Y chromosome is lacking. We describe here the localization of a gene to the tip of the short arm of the human X chromosome and evidence for a related gene on the Y chromosome.
D000483:Alleles; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000235:genetics; D005075:Biological Evolution; D000939:Epitopes; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012730:Sex Chromosomes / Q000502:physiology*; D014960:X Chromosome / Q000502:physiology*; D014998:Y Chromosome / Q000502:physiology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D000939:Epitopes