[Effect of aminazin on hydrolase activity of the blood and their excretion by the kidneys].
Chronic experiments in dogs revealed that 0.5 mg/kg of aminasin did not affect the content of pepsinogen, amylase and lipase in the peripheral blood plasma but somewhat increased the variability of the blood pepsinogen and lipase. 2 mg/kg of aminasin decreased the pepsinogen content in the blood; 5 mg/kg decreased the amylase level as well. Aminasin decreased the renal excretion of pepsinogen in direct proportion to its dosage. 5 mg/kg of aminasin decreased the renal excretion of amylase as well, with no considerable effect on the renal excretion of lipase. Aminasin (5 mg/kg) delayed the period of restoration of the blood level of amylase and pepsinogen administered parenterally, and intensified the disenzymemia caused by pepsinogen administration; the renal excretion of enzymes was decreased. The central nervous mechanisms responding to the above doses of aminasin are concluded to play a major role in maintaining the homeostasis of hydrolytic enzymes in the blood.
D000681:Amylases / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002746:Chlorpromazine / Q000097:blood / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006706:Homeostasis / Q000187:drug effects; D006867:Hydrolases / Q000032:analysis / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008049:Lipase / Q000378:metabolism; D010435:Pepsinogens / Q000378:metabolism / Q000494:pharmacology
D010435:Pepsinogens; D006867:Hydrolases; D008049:Lipase; D000681:Amylases; D002746:Chlorpromazine
Vliianie aminazina na aktivnost' gidrolaz v krovi i ikh vydelenie pochkami.