Comparison of effects of pentagastrin and gastrin on rat colon mucosa.
The trophic effect of chronic endogenous hypergastrinemia is compared with that of short term injected pentagastrin on colon mucosa of rats. Hypergastrinemia was achieved by antral exclusion. Pentagastrin (2 mg/kg) was administered to a group of sham operated rats every 12 hr for 48 hr prior to sacrifice. Normogastrinemic antrectomized and sham operated animals were studied as controls. Tissue content and synthesis of DNA, RNA, and protein were all markedly increased by both endogenous gastrin and exogenous pentagastrin. The stimulation by gastrin was significantly stronger than that of pentagastrin at the chosen schedule of administration.
D000818:Animals; D003106:Colon / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D005755:Gastrins / Q000097:blood / Q000502:physiology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D005755:Gastrins; D012313:RNA; D004247:DNA; D010418:Pentagastrin