Some aspects of contrast medium chemotoxicity.
Intravascular contrast media exhibit a non-specific toxicity on account of their hyperosmolarity and a molecule specific toxicity which has been labelled 'chemotoxicity'. The new generation of low osmolar contrast media has achieved its purpose of greatly reducing the importance of the former and data are presented which demonstrate that all the new media also possess significantly lower chemotoxicity than their conventional predecessors. On most criteria iohexol has the lowest chemotoxicity of any of the available media.
D001777:Blood Coagulation / Q000187:drug effects; D003167:Complement Activation / Q000187:drug effects; D003287:Contrast Media / Q000633:toxicity*; D004791:Enzyme Inhibitors / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007463:Iodobenzoates / Q000633:toxicity*; D007472:Iohexol; D009994:Osmolar Concentration; D011485:Protein Binding / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000633:toxicity*
D003287:Contrast Media; D004791:Enzyme Inhibitors; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol