Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat.
The concentration of insulin that produces half-maximal stimulation of glycolysis by stripped soleus muscle preparations is markedly increased by the adenosine analogues, 2-chloroadenosine and N6-phenylisopropyladenosine, but is markedly decreased by the methyl xanthine analogue, 8-phenyltheophylline. 2-Chloroadenosine increases the concentration of insulin required to stimulate glycolysis half maximally, from about 100 to 2000 mu units/ml. 8-Phenyltheophylline decreases this concentration of insulin from about 100 to 10 mu units/ml, an effect which is similar to that produced either by addition of adenosine deaminase to the medium or to exercise-training of the donor animals for 4 weeks.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis; D006019:Glycolysis / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009132:Muscles / Q000187:drug effects*; D010660:Phenylisopropyladenosine / Q000494:pharmacology*; D051381:Rats; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology
D007328:Insulin; D007773:Lactates; D015762:2-Chloroadenosine; D010660:Phenylisopropyladenosine; D019344:Lactic Acid; D006003:Glycogen; D013806:Theophylline; C028322:8-phenyltheophylline; D005947:Glucose; D000241:Adenosine; D015056:1-Methyl-3-isobutylxanthine