[Production of histamine induced by a lymphokine during infection with Nippostrongylus brasiliensis].
Spleen cells from Mice infected with N. brasiliensis produce a large amount of histamine in response to adult worm antigenic extract, to con A, or during primary MLC. During worm antigenic or con A response, this phenomenon results from an increase in HCSF production and HCSF sensitivity. During primary MLC, only an increase in HCSF sensitivity is observed without increase in HCSF production. This increase in histamine and HCSF production is correlated with the "self-cure" phenomenon.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008222:Lymphokines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009349:Nematode Infections / Q000276:immunology*; D009559:Nippostrongylus / Q000276:immunology*
D008222:Lymphokines; D003208:Concanavalin A
Production d'histamine induite par une lymphokine au cours des infestations par Nippostrongylus brasiliensis.