Effects of semicarbazide on DNA, RNA and protein hepatic levels on four subsequent generations of Wistar rats.
1. The offspring (F1) of a parent generation (P) were mated on a brother-to-sister system to produce a second generation (F2), which was then mated in the same way to produce a third generation (F3). 2. Each of these generations were divided into two groups, controls and treated. 3. A single dose of 100 mg/kg of semicarbazide was administered to the treated Wistar rats on the 10th day of their pregnancy. 4. DNA, RNA and protein hepatic levels were measured in the livers of either 21-day-old foetuses or 1, 7, 15 or 30-day-old offspring. 5. These levels were also studied in the pregnant rats on day 21 of gestation. 6. Semicarbazide produced a significant decrease of these levels not only in the foetuses, offspring and pregnant rats but also in the controls, F2 and F3, from treated P and F1 respectively.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012663:Semicarbazides / Q000494:pharmacology*
D011506:Proteins; D012663:Semicarbazides; D012313:RNA; D004247:DNA