The heterophile transplantation antigen (HT-A) system: a unique heterophile system exhibiting multiple specificities.
Although many characteristics of the heterophile transplantation antigen (HT-A) system have been determined, definitive information regarding certain aspects of the system is still lacking. In an effort to obtain such information concerning the number of HT-antigen and antibody specificities (i.e. single or multiple) and the distribution of HT-A among selected mammalian and avian species, the present study was conducted. In this study, the ability of erythrocytes from several species to absorb the anti-HT-A activity from 6 anti-HT-A sera was determined with a quantitative inhibition of hemagglutination assay utilizing an electronic particle counter. Careful analysis of the results of these experiments indicated the existence of multiple (i.e. 5 or more) HT-antigen and antibody specificities. The distribution of these HT-antigens among selected mammalian and avian species was not identical to the distribution of any well-characterized heterophile antigen of which we are aware. Therefore, none of the HT-A specificities defined in this study are identical to previously described heterophile antigens. These findings confirm and expand previous knowledge of the HT-A system and have facilitated formulation of hypotheses regarding the role of multiple specificities in acute renal allograft rejection and the genetics of HT-A expression in humans.
D000818:Animals; D000918:Antibody Specificity; D015478:Antigens, Heterophile / Q000235:genetics*; D002415:Cats; D002417:Cattle; D002645:Chickens; D004285:Dogs; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013045:Species Specificity
D015478:Antigens, Heterophile; D000939:Epitopes; D006649:Histocompatibility Antigens