[Cholestasis after antiarrhythmic therapy with propafenone].
Propafenone, three times 150 mg/d over 33 days and two years later at the same dosage over six days, was administered to an 84-year-old man with ventricular extrasystoles (Lown IVa). Both times intrahepatic biliary stasis occurred, presumably a sign of a drug-allergic hepatitis. All other possible causes in the differential diagnosis were excluded. The lymphocyte transformation test demonstrated in vitro propafenone-sensitive patient-lymphocytes.
D000368:Aged; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D002779:Cholestasis / Q000139:chemically induced*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D011405:Propafenone; D011427:Propiophenones / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use
D011427:Propiophenones; D011405:Propafenone
Cholestase nach antiarrhythmischer Therapie mit Propafenon.