Characterization of the beta receptor responsible for enhanced histamine release from bovine leukocytes.
The present study was undertaken to determine the beta-receptor subtype responsible for the enhanced anaphylactic histamine release from bovine leukocytes produced by isoprenaline. The selective beta 1 antagonist practolol competitively inhibited the enhancement of histamine release produced by isoprenaline. The selective beta 2 agonists salbutamol and terbutaline produce no significant effect on antigen-induced histamine release. This indicates that the receptor responsible for enhancement of histamine release from bovine granulocytes is of the beta 1 subtype. The question is raised as to whether this is a normal physiological response or an abnormal condition produced by the sensitization procedure.
D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D006636:Histamine Release / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D011217:Practolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; D000420:Albuterol; D011217:Practolol