title: The influence of some pteridines on pineal 5-methoxyindole synthesis in male Wistar rats periodically exposed to either white or green light.
abstract: The pineals of 28 days old male Wistar rats, in December periodically exposed to either white or green light, were incubated with pterin-6-aldehyde or reduced neopterin. In white light the rhythm of synthesis of 5-methoxytryptophan and of 5-methoxyindole-3-acetic acid was clearly influenced by the pteridines mentioned. In green light a change in rhythmicity of 5-methoxytryptophan, 5-methoxytryptamine and of melatonin/5-methoxytryptophol synthesis by the pteridines was observed. In white light both pteridines increased 5-methoxytryptophan and decreased 5-methoxyindole-3-acetic acid synthesis. Reduced neopterin stimulated 5-methoxytryptamine synthesis and inhibited melatonin/5-methoxytryptophol synthesis. Pterin-6-aldehyde showed an opposite effect. In green light both pteridines decreased 5-methoxytryptophan synthesis, but increased 5-methoxyindole-3-acetic acid and 5-methoxytryptamine synthesis. Melatonin/5-methoxytryptophol synthesis was decreased by reduced neopterin and increased by pterin-6-aldehyde. The results suggest an indolic metabolic pathway leading from 5-methoxytryptophan via 5-methoxytryptamine to melatonin, while pteridines and light of different wave lengths are correlated in regulating indole metabolism.
mesh_terms: D008735:5-Methoxytryptamine / Q000096:biosynthesis; D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives / Q000096:biosynthesis; D007211:Indoles / Q000096:biosynthesis*; D008027:Light; D008297:Male; D008543:Melanins / Q000096:biosynthesis; D019798:Neopterin; D010870:Pineal Gland / Q000378:metabolism*; D011621:Pteridines / Q000494:pharmacology*; D011622:Pterins; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000031:analogs & derivatives / Q000096:biosynthesis
chemical_list: D007211:Indoles; D008543:Melanins; D011621:Pteridines; D011622:Pterins; D001708:Biopterins; C027986:5-methoxytryptophan; C001736:5-methoxyindoleacetic acid; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid; D019798:Neopterin; C002465:methoxytryptophol; C005926:2-amino-4-hydroxy-6-formylpteridine; D014364:Tryptophan