[Comparison of natural and synthetic ligands for determining androgen receptors in prostatic tumors and prostatic nodular hyperplasia].
No difference was found in the values of the equal constants of dissociation and the number of sites specifically binding [3H] DHT and [3H] R1881 in the cytosols of tumor cells and human prostatic nodular hyperplasia. The above data suggest that in the determination of cytoplasmic androgen receptors in healthy and tumorous tissues of the target organs one can use both natural (DHT) and synthetic (R1881) steroids precipitating the hormone-receptor complex with protamin sulphate.
D013196:Dihydrotestosterone / Q000378:metabolism*; D004963:Estrenes / Q000378:metabolism*; D006801:Humans; D008297:Male; D015741:Metribolone; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000032:analysis*; D011944:Receptors, Androgen / Q000032:analysis*; D011987:Receptors, Steroid / Q000032:analysis*; D045165:Testosterone Congeners / Q000378:metabolism
D004963:Estrenes; D011944:Receptors, Androgen; D011987:Receptors, Steroid; D045165:Testosterone Congeners; D013196:Dihydrotestosterone; D015741:Metribolone
Sravnenie prirodnogo i sinteticheskogo ligandov pri opredelenii retseptorov androgenov v opukholiakh i pri noduliarnoĭ giperplazii predstatel'noĭ zhelezy cheloveka.