Neurochemical and activity changes in rats infected with Trypanosoma brucei gambiense.
The brains of rats infected with Trypanosoma brucei gambiense were analyzed for their content of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindoleacetic acid (5-HIAA). In the caudate of infected rats, dopamine levels increased by 34% and 5-HIAA levels by 20%. DOPAC levels declined by 30% in the caudate, but this change was significant at only P less than 0.1. In the pons/medulla of infected rats the serotonin concentration dropped by 21% and the 5-HIAA concentration rose by 25%. Activity levels in infected rats decreased by 49% (gross movement) and 44% (total movement) relative to those of uninfected control rats.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008526:Medulla Oblongata / Q000378:metabolism; D009043:Motor Activity; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010648:Phenylacetates / Q000378:metabolism*; D011149:Pons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D014347:Trypanosoma brucei gambiense; D014353:Trypanosomiasis, African / Q000378:metabolism* / Q000503:physiopathology
D018377:Neurotransmitter Agents; D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine