Heparan structure and the modulation of angiogenesis.
It is postulated that the angiogenic potential of tissues is influenced by the fine structure of heparan glycosaminoglycans present in the tissues. Possible mechanisms involved are discussed. It is suggested that compounds chemically related to heparans might usefully act as inhibitors of pathological angiogenesis.
D002196:Capillaries / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism*; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D013329:Structure-Activity Relationship
D006025:Glycosaminoglycans; D006493:Heparin; D006497:Heparan Sulfate