Modulation by S-adenosyl-methionine and S-adenosyl-homocysteine of the human leucocytes histamine release.
Methylation of membrane phospholipids is an important stage in the process of histamine release. This methylation reaction can be modulated by S-adenosyl-methionine (SAM) as well as by S-adenosyl-homocysteine (SAH). The influence of SAM and of SAH upon the histamine release of leucocytes from asthmatic and normal subjects were compared. In concentration of 10(-4) M, SAM enhanced spontaneous and the specifically induced histamine release. In concentration of 10(-5) M SAM enhanced the histamine release only in normals. This phenomenon could indicate a deficit in methyl-transferase activity in the asthamatics. In concentration of 10(-4) M, SAH reduced spontaneous and specifically induced histamine release, having an effect comparable to that of 10(-4) M Theophylline.
D000485:Allergens / Q000276:immunology; D004205:Cromolyn Sodium / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006710:Homocysteine / Q000031:analogs & derivatives*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D012435:S-Adenosylhomocysteine / Q000494:pharmacology*; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology
D000485:Allergens; D006710:Homocysteine; D012436:S-Adenosylmethionine; D012435:S-Adenosylhomocysteine; D013806:Theophylline; D004205:Cromolyn Sodium