title: Modelling compound action potentials of peripheral nerves in situ. III. Nerve propagation in the refractory period.
abstract: Compound nerve action potentials (CAPs) of sural nerves of healthy persons were measured in the relative refractory period of the fibres. Double stimuli were used with interstimulus intervals ranging from 0.7 to 4.0 msec. The CAP latency increase, its amplitude decrease and its wave shape alterations with decreasing interstimulus interval are discussed, using a model description. Recovery functions for the single fibre action potential in the relative refractory period are defined. These recovery functions, however, cannot sufficiently explain the CAP amplitude diminutions actually measured. Apparently in the relative refractory period an increasing number of fibres ceases to propagate an action potential when the stimulus interval is shortened. This effect, which is caused by subthreshold stimulation, predominantly involves the slower fibres. The usual derivation of refractory period parameters in clinical practice is reviewed.
mesh_terms: D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009431:Neural Conduction; D013127:Spinal Nerves / Q000502:physiology*; D013497:Sural Nerve / Q000502:physiology*