[Study of the structure and metabolism of the rat thymus gland during long-term administration of tritium oxide in different doses].
During-3-month administration of tritium oxide (0.37, 0.925 and 1.85 MBq/g body weight) to rats one could observe the loss of the thymus weight, decrease in the concentration, content and production of DNA and RNA per organ, reduction of the molecular weight of single-stranded DNA, increase in the content of the salt-soluble polydeoxyribonucleotides, and activation of acidic DNAases. These changes were function of tritium dose daily administered to rats.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004277:DNA, Single-Stranded; D003851:Deoxyribonucleases / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D008297:Male; D008970:Molecular Weight; D011089:Polydeoxyribonucleotides / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors; D014316:Tritium / Q000008:administration & dosage*; D014867:Water / Q000008:administration & dosage*
D004277:DNA, Single-Stranded; D011089:Polydeoxyribonucleotides; D014867:Water; D014316:Tritium; C033961:tritium oxide; D012313:RNA; D004247:DNA; D003851:Deoxyribonucleases
Izuchenie struktury i obmena nukleinovykh kislot vilochkovoĭ zhelezy krys pri dlitel'nom vvedenii okisi tritiia v raznykh dozakh.