Detection of interferon in the sera of patients with psoriasis, and its enhancement by PUVA treatment.
Interferon-like activity could be detected in the sera of nineteen psoriatic patients (interferon titres between 8 and 64 i.u./ml), whereas healthy controls were negative. Following PUVA treatment the interferon levels increased significantly (interferon titres between 32 and 128 i.u./ml). An enhanced interferon production could explain some of the immunological phenomena connected with PUVA treatment.
D000328:Adult; D005260:Female; D006801:Humans; D007372:Interferons / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy / Q000276:immunology*
D007372:Interferons