The influence of the ev 3 locus on the inducibility of serum antibody reactivity for envelope glycoprotein group-specific determinants.
Chickens segregating for the ev 3 locus were bred by backcross matings of line 6(3) to line 15B. Analysis of RAV-1-infected segregants indicated that inducibility of antibody reactivity for envelope glycoprotein group-specific determinants correlated with the absence of ev 3, whereas noninducibility correlated with the presence of ev 3. Since the ev 3(+) and ev 3(-) segregants possessed similar genetic backgrounds, these results provide direct evidence that the ev 3 locus determines the phenotype of noninducibility.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001354:Avian Leukosis Virus / Q000502:physiology; D002645:Chickens / Q000235:genetics*; D000939:Epitopes; D005814:Genes, Viral; D012190:Retroviridae / Q000235:genetics* / Q000276:immunology; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D014759:Viral Envelope Proteins; D014764:Viral Proteins