[Concentration of acid-stable inhibitors--metabolites of plasma inter-alpha trypsin inhibitor--in the urine of healthy people and in patients with nephrotic syndrome].
Concentration of acid stable inhibitors (ASI)--metabolites of plasma inter-alpha-trypsin inhibitor--was measured in urine samples of healthy persons and of 6 patients with nephrotic syndrome by means of modified cross immunoelectrophoresis. There was obtained 2-25 mg of ASI (Mr 22,000 and 32,000) in diurnal urine samples of patients with nephrotic syndrome, which were 10-20 times higher as compared with these inhibitors level in the urine of healthy persons. The reverse correlation was established for the value of glomerular filtration and the lever of ASI (Mr 32,000) in the urine of patients with nephrotic syndrome.
D000328:Adult; D000510:Alpha-Globulins / Q000652:urine*; D010450:Endopeptidases / Q000652:urine*; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000503:physiopathology / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007123:Immunoelectrophoresis, Two-Dimensional; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000503:physiopathology / Q000652:urine; D009404:Nephrotic Syndrome / Q000503:physiopathology / Q000652:urine*; D014361:Trypsin Inhibitors / Q000652:urine*
D000510:Alpha-Globulins; D014361:Trypsin Inhibitors; C011877:inter-alpha-inhibitor; D010450:Endopeptidases
Kontsentratsiia kislotostabil'nykh ingibitorov--proizvodnykh inter-al'fa-ingibitora tripsina plazmy krovi--v moche zdorovykh liudeĭ i bol'nykh s nefroticheskim sindromom.