[Histamine and immune reactions. 1. Histamine receptor-bearing lymphocytes].
Literature review. Mast cells and basophils are included not only in anaphylactic but also in complement activating and cell-mediated immune reactions. A histamine release can be induced via the IgE mechanism, the anaphylatoxins, the histamine releasing activity, and by other reactions. Histamine and several other mediators induce a local inflammation reaction either by a direct action on their target cells or indirectly by the activation of other humoral and/or cellular effector systems. Histamine influences several immune reactions. Here, its influence on histamine receptor-bearing lymphocytes is discussed more in detail. Using in vitro test systems, it has been shown that histamine has a dual effect, it induces a suppression when applied in higher concentrations, while low concentrations are stimulating. In vivo, histamine receptor-bearing lymphocytes have suppressive functions, mediated by H2 receptors. Some preliminary evidence for the inclusion on histamine in the immunoreagulation of patients with several diseases is presented.
D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D001491:Basophils / Q000276:immunology; D002645:Chickens; D004285:Dogs; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D006632:Histamine / Q000494:pharmacology; D006636:Histamine Release; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification / Q000378:metabolism*; D008407:Mast Cells / Q000276:immunology; D051379:Mice; D051381:Rats; D011968:Receptors, Histamine / Q000032:analysis*
D011968:Receptors, Histamine; D007073:Immunoglobulin E; D006632:Histamine
Histamin und Immunreaktionen. 1. Histaminrezeptor-tragende Lymphozyten.