title: Enhanced antitumor effects of bleomycin and moderate hyperthermia by additional use of ethanol.
abstract: The combined effects of moderate local hyperthermia, bleomycin and ethanol were investigated with Lewis lung carcinoma tumors in female C57BL/6 mice. Different combinations of treatments were performed on days 4 and 7 after tumor implantation. Combined treatment of 41 degrees C hyperthermia and bleomycin resulted in mild reductions of tumor growth. Hyperthermia plus bleomycin led to marked reduction in tumor growth under the condition of a 43 degrees C temperature. The antitumor effects of 41 degrees C hyperthermia combined with bleomycin were enhanced by the additional use of ethanol, and these effects were more remarkable than those of 43 degrees C hyperthermia and bleomycin. A possible application of these findings to clinical therapy for advanced esophageal cancer was discussed.
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000494:pharmacology / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003131:Combined Modality Therapy; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006979:Hyperthermia, Induced; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D011379:Prognosis
chemical_list: D001761:Bleomycin; D000431:Ethanol