title: Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum.
abstract: In addition to its previously characterized, six different polypeptide components, signal recognition protein--which functions in protein translocation across and integration into the endoplasmic reticulum membrane--contains a 7S RNA molecule. The RNA is closely identified with the small cytoplasmic 7SL RNA and is required for both structural and functional properties of signal recognition protein--which we therefore rename signal recognition particle.
mesh_terms: D000818:Animals; D001483:Base Sequence; D001692:Biological Transport; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000502:physiology*; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000502:physiology; D010455:Peptides / Q000378:metabolism* / Q000502:physiology; D011498:Protein Precursors / Q000378:metabolism*; D021382:Protein Sorting Signals; D012313:RNA / Q000502:physiology*; D012342:RNA, Small Nuclear; D012261:Ribonucleoproteins / Q000502:physiology; D017411:Ribonucleoproteins, Small Nuclear; D012270:Ribosomes / Q000378:metabolism*
chemical_list: D046911:Macromolecular Substances; D008565:Membrane Proteins; D010455:Peptides; D011498:Protein Precursors; D021382:Protein Sorting Signals; D012342:RNA, Small Nuclear; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D012313:RNA