[ADP ribosylation of proteins and its role in regulating functional cellular activity].
New data are presented on ADP-ribosylation of nuclear proteins, which is one of the paths of their postsynthetic modifications. The importance of this reaction for DNA cell cycle regulation are discussed. The structure of mono- and poly(ADPRib), the properties of their synthesis and degradation catalyzing enzymes, and the nature of the modified proteins are considered.
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism; D002477:Cells / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D006801:Humans; D008968:Molecular Conformation; D009244:NAD+ Nucleosidase / Q000378:metabolism*; D009698:Nucleoproteins / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis
D009698:Nucleoproteins; D011506:Proteins; D012313:RNA; D000255:Adenosine Triphosphate; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases; D009244:NAD+ Nucleosidase
ADF-ribozilirovanie belkov i ego rol' v reguliatsii funktsional'noĭ aktivnosti kletok.