Simultaneous expression of globin genes for embryonic and adult hemoglobins during mammalian ontogeny.
The dominant hemoglobin of the adult hamster was detected in yolk-sac erythroid cells, and its identity was confirmed by peptide mapping and by analysis of relevant peptides. Both the presence and active synthesis of two embryonic hemoglobins presumed to exist only in yolk-sac erythroid cells were detected in neonatal liver and spleen. Thus the time span of expression of both embryonic and adult globin genes during mammalian ontogeny may be considerably broader than presently believed.
D000367:Age Factors; D000818:Animals; D006224:Cricetinae; D005319:Fetal Hemoglobin / Q000235:genetics; D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics*; D008099:Liver / Q000502:physiology*; D013154:Spleen / Q000502:physiology; D015017:Yolk Sac / Q000502:physiology*
D005914:Globins; D005319:Fetal Hemoglobin