Antigenic relatedness of two strains of hepatitis A virus determined by cross-neutralization.
Cell culture-adapted HM-175 (Australia) and PA-21 (Panama) strains of hepatitis A virus were compared in a cross-neutralization radioimmunofocus inhibition assay. The ratio of antibody titers achieved with two sera against the two viruses differed by less than twofold, indicating a high degree of antigenic relatedness between epidemiologically disparate strains of virus.
D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology*; D000939:Epitopes; D035922:Hepatitis A Antibodies; D006507:Hepatovirus / Q000276:immunology*; D009500:Neutralization Tests; D013045:Species Specificity
D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D035922:Hepatitis A Antibodies