Flow cytometric analysis of human lung cancer. Correlation with histologic type and stage.
DNA ploidy and cell-cycle characteristics of 65 operable lung cancers (41 adenocarcinomas, 19 epidermoid carcinomas, 3 large-cell carcinomas and 2 small-cell carcinomas) were analyzed using flow cytometry. Eighty percent of the tumors were aneuploid. The mean DNA index was lower in epidermoid than in adenocarcinoma. In adenocarcinoma, a low DNA index was correlated with early-stage disease; no correlation between DNA index and stage was observed in the other cell types. The %S-phase cells was highest in two cases of undifferentiated large-cell carcinoma and lowest in adenocarcinoma. The RNA index was increased approximately two-fold in all cell types. Longer follow-ups will be required to establish any correlation between the cell kinetic measurements reported here and survival times.
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D004247:DNA / Q000235:genetics; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D009367:Neoplasm Staging; D011003:Ploidies; D012313:RNA / Q000235:genetics
D012313:RNA; D004247:DNA