[Clinical study of the auxiliary action of bleomycin in surgery and radiotherapy of cervical cancer and evaluation of modes of administration for the enhancement of the effects and alleviation of the adverse effects].
A total of 54 cases of carcinoma of the uterine cervix were treated with bleomycin adjuvant to surgery and radiation. Bleomycin was injected intravenously or continuously intraarterially or, using oleaginous bleomycin, locally into the infravaginal portion of the cervix, and its significance in administration routes was evaluated in terms of a five-year survival rate. Furthermore, how bleomycin concentrates in the blood, cancerous lesions and regional lymphnodes was examined after administration using following various methods: an aqueous bleomycin, intravenously, continuously intraarterially, and through dispersion to intrapelvic dead space or injected as an oleaginous bleomycin locally to infravaginal portion or applied as vaginal suppository and cervical pellet. Most appropriate routes with increased focal concentrations and reduced blood concentrations proved to enhance anti-neoplastic effects and alleviate side effects. Among them, results with local injection of oleaginous bleomycin to infravaginal portion and continuous intraarterial injection of aqueous bleomycin were most satisfactory. Complete relief from cervical carcinoma by single administration of bleomycin alone is hardly attainable; however, the efficacy of bleomycin as an adjuvant therapy, using a several types of the bleomycins, is highly appreciated in combination with pre- and post-operative treatment and radiotherapy.
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007275:Injections, Intravenous; D008875:Middle Aged; D009824:Ointments; D013488:Suppositories; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D009824:Ointments; D013488:Suppositories; D001761:Bleomycin