A probe of the human plasmin-alpha 2-macroglobulin interaction utilizing monoclonal antibodies to human plasmin.
These experiments have shown that alpha 2M may have a bait region capable of accommodating proteases of a far greater molecular weight than previously recognized, since antibody-plasmin complexes apparently become entrapped. In the case of large proteases, however, it now appears that a portion of these molecules is not enclosed. Clearly, in the case of plasmin, the K1-4 region remains outside the molecular trap.
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D005341:Fibrinolysin / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D010446:Peptide Fragments / Q000032:analysis; D010958:Plasminogen / Q000378:metabolism; D011485:Protein Binding; D000511:alpha-Macroglobulins / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D010446:Peptide Fragments; D000511:alpha-Macroglobulins; D010958:Plasminogen; D005341:Fibrinolysin