Carbohydrate metabolites in the blood and CSF of patients with neuromuscular disorders.
The concentrations of glucose, pyruvate and lactate were determined in the blood and lumbar CSF of 63 patients with neuromuscular disorders and 40 controls. The glucose/lactate and lactate/pyruvate ratios were also calculated, in addition to the cytoplasmic NADH/NAD+ (nicotinamide-adenine dinucleotide-H/nicotinamide-adenine dinucleotide) ratio in the brain. Remarkable deviations from control values were found not only in blood but also in the CSF of patients with different neuromuscular diseases, particularly in Duchenne muscular dystrophy and peroneal muscular atrophy, indicative of disturbance of the carbohydrate metabolism in the central nervous system.
D001786:Blood Glucose / Q000032:analysis; D001923:Brain Chemistry; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D007773:Lactates / Q000097:blood / Q000134:cerebrospinal fluid; D009243:NAD / Q000097:blood / Q000134:cerebrospinal fluid; D009468:Neuromuscular Diseases / Q000097:blood* / Q000134:cerebrospinal fluid; D011773:Pyruvates / Q000097:blood / Q000134:cerebrospinal fluid; D019289:Pyruvic Acid
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D009243:NAD; D019289:Pyruvic Acid; D005947:Glucose