Short-term-toxicity of 4-methyl-1-phenylpentan-2-ol in rats.
Groups of 15 male and 15 female rats were given diets to provide intakes of 0 (control), 10, 40 or 160 mg 4-methyl-1-phenylpentan-2-ol/kg/day for 13 wk. No effects attributable to treatment were seen in the 10-mg/kg/day dose group. At 40 mg/kg/day the only finding was a decrease in serum glucose in males. This was of questionable toxicological significance. At 160 mg/kg/day a reduction in weight gain, probably due to unpalatability, a mild proteinuria in the females, an increased relative liver weight in males, increased caecal weights, a reduction in serum glucose and a lower reticulocyte count were recorded. No changes were observed in the histopathological examination. The no-untoward-effect level established in this study was 10 mg/kg/day.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000031:analogs & derivatives*; D005260:Female; D005421:Flavoring Agents / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014886:Weaning
D001786:Blood Glucose; D005421:Flavoring Agents; C039407:4-methyl-1-phenylpentan-2-ol; D000431:Ethanol; D010626:Phenylethyl Alcohol