[Prevention of ventricular fibrillation using lidocaine in the acute period of a myocardial infarct].
Two randomized investigations have shown a possibility to prevent primary ventricular fibrillation in acute myocardial infarction by lidocain. The first investigation was conducted in an intensive care unit on 316 patients hospitalized on an average 6 hours after the onset of acute myocardial infarction. 155 patients were included into a control group. Since the hospitalization 161 patients had been receiving lidocain (trimecain) intravenously and then intramuscularly for a day. The second investigation was conducted in accordance with the program "Myocardial Infarction Register" in a small town for 28 years. The sudden death rates among the patients who had been emergency cases within the first year were control. In subsequent 1.8 years all these patients received lidocain intramuscularly. The findings suggest that lidocain significantly reduces the incidence of primary ventricular fibrillation without suppressing ventricular rhythm disturbances completely.
D005117:Cardiac Complexes, Premature / Q000517:prevention & control; D003422:Critical Care / Q000379:methods; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D014288:Trimecaine / Q000627:therapeutic use; D014693:Ventricular Fibrillation / Q000517:prevention & control*
D008012:Lidocaine; D014288:Trimecaine
Profilaktika fibrilliatsii zheludochkov s pomosch'iu lidokaina v ostrom periode infarkta miokarda.