title: Studies on pathogenicity and immunogenicity of cold adapted variants of influenza virus.
abstract: Cold adapted variants of influenza virus, replicated at 37, 35, 33 and 30 degrees C, were tested for capability to multiply in ferrets and to induce H and N antibodies. Virus grown at 30 degrees C differed from the other in electrophoretic mobility of its polypeptides in PAGE, in inducing higher level of N antibodies, and in higher intensity of immunofluorescence reaction in the respiratory tract.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000302:isolation & purification; D002642:Chick Embryo; D003080:Cold Temperature; D005289:Ferrets; D005455:Fluorescent Antibody Technique; D006385:Hemagglutination Inhibition Tests; D008168:Lung / Q000382:microbiology; D009975:Orthomyxoviridae / Q000276:immunology / Q000472:pathogenicity*; D009976:Orthomyxoviridae Infections / Q000382:microbiology*; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral