Globin synthetic ratios in homozygous beta-thalassemia patients from Lebanon.
We have studied patients with beta-thalassemia from a Lebanese population having a high rate of consanguineous matings. This population exhibits both elevated and normal levels of Hb A2 associated with high levels of Hb F in homozygotes. The clinical course of the anemia suggests that this population consists of the severe Mediterranean type. Twenty-three unrelated homozygous beta-thalassemia patients investigated for globin synthetic ratios, consisted of 18 beta+ and 5 beta 0 with a non-alpha/alpha range of 0.158-0.465 and 0.25-0.41, respectively. The percentage of G gamma chains in Hb F was determined for 21 of these patients and a mean value of 59% G gamma chain content was found.
D004589:Electrophoresis, Disc; D005319:Fetal Hemoglobin / Q000032:analysis; D005914:Globins / Q000235:genetics* / Q000302:isolation & purification; D006443:Hemoglobin A2 / Q000032:analysis; D006720:Homozygote; D006801:Humans; D007861:Lebanon; D046911:Macromolecular Substances; D013789:Thalassemia / Q000097:blood / Q000235:genetics*
D046911:Macromolecular Substances; D005914:Globins; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin