Non-effectivity of roentgen irradiation in an in vivo rapidly growing murine lymphosarcoma.
The survival time of mice bearing a rapidly growing murine lymphosarcoma (cell doubling time 9.6 h) is hardly influenced by roentgen irradiation with fractions of 2 Gy, not even if delivered according to superfractionated schedules. Growth kinetic measurements reveal an almost complete mitotic block 6 h after exposure, followed by a large overshoot in cell proliferative activity. The dose-response curve for in vivo irradiated cells has a D0 of 1.9 and lacks a shoulder. Hence, repair of sublethal damage must be of restricted significance. The extremely strong proliferative capability appears to lead to rapid repopulation of the tumour. Typically, surviving cells show a high content of RNA and protein.
D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis; D007399:Interphase; D008099:Liver / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000528:radiation effects; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D011879:Radiotherapy Dosage; D013154:Spleen / Q000473:pathology; D013997:Time Factors; D014916:Whole-Body Irradiation
D012313:RNA; D004247:DNA