Association between the 7 S RNA and the lupus La protein varies among cell types.
The La antigen recognized by certain lupus erythematosus autoantibodies was found to be predominantly associated with 7 S RNA in baby hamster kidney cells and human Raji cells, but not in HeLa cells where mainly the 7-2 RNA was associated with the La protein. In mouse myeloma cells (MPC-11) and mouse lymphoma cells (WEHI) that secrete immunoglobulins, equal amounts of 7 S and 7-2 RNAs were present in anti-La immunoprecipitates. The highly conserved 7 S RNA is a component of the signal recognition particle involved in protein secretion (Walter, P., and Blobel, G. (1982) Nature (Lond.) 299, 691-698), and its association with the La antigen appeared to be cell-type specific. Thus, it is possible that the La-7 S RNA association correlates with the abundance of 7 S RNA or with the secretory activity of the cell type.
D000818:Animals; D000941:Antigens / Q000235:genetics*; D001324:Autoantigens; D002460:Cell Line; D002478:Cells, Cultured; D006224:Cricetinae; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D008970:Molecular Weight; D012313:RNA / Q000235:genetics* / Q000302:isolation & purification; D012261:Ribonucleoproteins / Q000235:genetics* / Q000302:isolation & purification; D000097585:SS-B Antigen
D000941:Antigens; D001324:Autoantigens; D012313:RNA; D012261:Ribonucleoproteins; D000097585:SS-B Antigen