title: Dietary sugar promotes gene activation in intestinal cell chromatin of adult rats.
abstract: The effect of dietary sucrose on transcription activity of chromatin from intestinal cells of adult rats was investigated. Chromatin-bound RNA polymerase II activity was significantly enhanced after feeding sucrose to rats. RNA polymerase II transcribes the genes coding for pre-messenger RNA. The results indicate that feeding of sucrose increased the synthesis of pre-messenger RNA molecules coding for specific proteins which are involved in the adaptive processes of sucrose hydrolysis in intestinal cells.
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D007583:Jejunum / Q000648:ultrastructure*; D008297:Male; D012313:RNA / Q000096:biosynthesis; D012319:RNA Polymerase II / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism; D013395:Sucrose / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D002843:Chromatin; D004040:Dietary Carbohydrates; D013395:Sucrose; D012313:RNA; D004247:DNA; D012319:RNA Polymerase II