Indomethacin and aspirin do not inhibit the antiviral or anti-proliferative actions of interferon.
Neither indomethacin nor aspirin, at concentrations which inhibited the formation of prostaglandins and prevented the interferon-induced increase in the intracellular concentration of cyclic GMP, had any significant effect on the development of the interferon-induced antiviral state either in mouse L1210 cells challenged with vesicular stomatitis virus or in mice infected with encephalomyocarditis virus. Furthermore, neither drug had any significant effect on the interferon-induced inhibition of cell multiplication in cultures of mouse leukaemia L1210 cells. The differences in the effects of these cyclo-oxygenase inhibitors on different interferon effects may provide some insight into the different pathways of interferon action.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004686:Encephalomyocarditis virus / Q000502:physiology; D007213:Indomethacin / Q000494:pharmacology*; D007372:Interferons / Q000037:antagonists & inhibitors*; D007939:Leukemia L1210; D014721:Vesicular stomatitis Indiana virus / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects*
D007372:Interferons; D001241:Aspirin; D007213:Indomethacin