Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus.
In infected cells, the RNA genomes of RNA tumour viruses are copied into DNA by a virus-encoded reverse transcriptase enzyme. This transfer of information from RNA into DNA was thought to be a unique feature of RNA tumour viruses, but recent results suggest it may be a more general strategy. Hepatitis B virus (HBV) has a double-stranded DNA genome, and it has recently been shown that the minus DNA strand of the HBV genome is copied from a plus-strand RNA template, leading to the suggestion that reverse transcription is central to the life cycle of HBV. More recently it has been suggested that the replication cycle of a plant virus, cauliflower mosaic virus (CaMV), includes a reverse transcription step. We report here the existence of amino acid sequence homology between retroviral reverse transcriptase and the putative polymerases of HBV and CaMV.
D000595:Amino Acid Sequence; D001358:Avian Sarcoma Viruses / Q000201:enzymology; D012321:DNA-Directed RNA Polymerases / Q000032:analysis*; D006515:Hepatitis B virus / Q000201:enzymology*; D009052:Leukemia Virus, Murine / Q000201:enzymology; D009029:Mosaic Viruses / Q000201:enzymology*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis*; D014764:Viral Proteins / Q000032:analysis
D014764:Viral Proteins; D012194:RNA-Directed DNA Polymerase; D012321:DNA-Directed RNA Polymerases