Spanish delta-beta-thalassemia: hematological studies and composition of the gamma-chains in ten homozygous patients.
We report the hematological studies and the composition of the gamma-chains of 10 homozygous delta beta(0)-thalassemia patients belonging to 6 families. These patients showed a mild to moderate chronic hemolytic anemia, morphological changes typical of thalassemia and 100% fetal hemoglobin in their peripheral blood. The homozygous studied synthesized A gamma- and G gamma-chains in approximately equal amounts, and the fetal hemoglobin with a threonyl residue at position 75 is present and accounts for all the A gamma production.
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis*; D005914:Globins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain; D013789:Thalassemia / Q000097:blood* / Q000453:epidemiology / Q000235:genetics
D005914:Globins; D005319:Fetal Hemoglobin