Pyrazolopyrimidine metabolism in the pathogenic trypanosomatidae.
Pyrazolopyrimidines are purine analogues. These compounds are metabolized by the pathogenic hemoflagellates and other members of the family Trypanosomatidae as though they were purines. This metabolic sequence does not exist in man or other mammals. In the hemoflagellates, the pyrazolopyrimidine base, of which allopurinol is the paradigm, undergoes ribosylphosphorylation to the ribonucleotide. This ribonucleotide may remain as such or be aminated to the amino analogue and further converted to the aminopyrazolopyrimidine ribonucleoside triphosphate. The latter is incorporated into RNA. This metabolic sequence has been demonstrated in the genera Leishmania and Trypanosoma.
D000493:Allopurinol / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000378:metabolism / Q000494:pharmacology*; D001029:Aotus trivirgatus; D014355:Chagas Disease / Q000188:drug therapy / Q000469:parasitology; D006801:Humans; D007891:Leishmania / Q000254:growth & development / Q000378:metabolism; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000469:parasitology; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000378:metabolism; D012263:Ribonucleosides / Q000378:metabolism / Q000494:pharmacology; D013872:Thionucleosides / Q000378:metabolism / Q000494:pharmacology; D014345:Trypanosoma / Q000254:growth & development / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000378:metabolism; D014352:Trypanosomiasis / Q000188:drug therapy* / Q000469:parasitology; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000469:parasitology
D000981:Antiprotozoal Agents; D012263:Ribonucleosides; D013872:Thionucleosides; C033494:thiopurinol ribonucleoside; D012313:RNA; D000493:Allopurinol; C005832:tisopurine; C021958:allopurinol riboside