Recent advances in the chemotherapy of herpes virus infections.
The main categories of antiherpes agents presently used in chemotherapy area reviewed according to the phase of virus replication affected : 1) virus adsorption (adamantane, nonionic surfactants) ; 2) eclipse (interferon) ; 3) virion maturation (nucleoside and nucleotide analogues and phosphonic acid derivatives). Mention is also made of other compounds--different synthetic organic derivatives, photodynamic dyes, metal ions, boric acid, hormones, antibiotics, other natural products (extracts from marine algae, propolis, garlic)--with promising antiviral properties. The difficulties and prospects of viral chemotherapy research are briefly discussed.
D000212:Acyclovir; D000218:Adamantane / Q000627:therapeutic use; D000547:Amantadine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001087:Arabinonucleosides / Q000627:therapeutic use; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004279:DNA, Viral / Q000378:metabolism; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005467:Floxuridine / Q000627:therapeutic use; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006564:Herpesviridae / Q000187:drug effects / Q000378:metabolism; D006566:Herpesviridae Infections / Q000188:drug therapy*; D006801:Humans; D007065:Idoxuridine / Q000627:therapeutic use; D007372:Interferons / Q000627:therapeutic use; D009705:Nucleosides / Q000627:therapeutic use; D009711:Nucleotides / Q000627:therapeutic use; D013501:Surface-Active Agents / Q000627:therapeutic use
D000998:Antiviral Agents; D001087:Arabinonucleosides; D004279:DNA, Viral; D009705:Nucleosides; D009711:Nucleotides; D013501:Surface-Active Agents; D005467:Floxuridine; C020235:brivudine; C012244:5-chloro-2'-deoxyuridine; D006147:Guanine; D007372:Interferons; D000547:Amantadine; D001973:Bromodeoxyuridine; C004279:tromantadine; D007065:Idoxuridine; D000218:Adamantane; D003857:Deoxyuridine; D000212:Acyclovir