The influence of the opiate antagonist naloxone on experimental pruritus.
The antipruritic effect of naloxone hydrochloride was evaluated in a double-blind, cross-over design. Systemic pretreatment with the opiate antagonist did not interfere with the cutaneous itch and flare responses evoked by morphine or histamine, nor did it inhibit the morphine-produced potentiation of the histamine-elicited skin reactions.
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006632:Histamine / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009020:Morphine / Q000009:adverse effects*; D009270:Naloxone / Q000627:therapeutic use*; D011537:Pruritus / Q000139:chemically induced* / Q000188:drug therapy
D009270:Naloxone; D009020:Morphine; D006632:Histamine