Maternal plasma HbF levels in pregnancy.
Serial maternal serum hemoglobin F (HbF) levels were measured by radioimmunoassay in 23 normal pregnancies. The maternal HbF fraction remains within the normal range during the first trimester (mean + 2 S.D. = 0.15 + 0.13). After 15 weeks gestation, maternal HbF levels rise in some, but not all, pregnancies. In about 30% of the cases the HbF fraction remains within the range seen in adult men and non-pregnant women. Irregular rises in HbF were found in other pregnancies studied serially. The maternal HbF fraction may be an indicator of transplacental hemorrhage.
D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis*; D005331:Fetomaternal Transfusion / Q000097:blood; D011247:Pregnancy; D011863:Radioimmunoassay
D005319:Fetal Hemoglobin