title: [Effect of anti-arrhythmia agents and nitroglycerin on enzyme activities of the liver].
abstract: In a prospective multicenter study the phenomenon of an anicteric reaction with increasing enzyme activities is tested with the antiarrhythmics prajmalin, propafenone, disopyramide and sparteine and additionally with nitroglycerine. Transaminases, alkaline phosphatase and gamma-GT increased with all five substances up to three times of the normal, concerning one, two or three and in a few cases four parameters. The bilirubin was always normal and no clinic symptoms were registered. Increased enzyme levels were found on the fourth day after exposition, the maximum on the 10th-16th day and normalisation on about the 25th day under continuing the same medication. No relation to age or sex was found. The results are discussed in comparison with the literature.
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy; D004798:Enzymes / Q000097:blood*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000009:adverse effects* / Q000627:therapeutic use; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000889:Anti-Arrhythmia Agents; D004798:Enzymes; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005996:Nitroglycerin
vernacular_title: Der Einfluss von Antiarrhythmika und Nitroglyzerin auf die Enzymaktivitäten der Leber.