Interferon production following NO2 exposure.
Studies were undertaken to assess the effects of nitrogen dioxide (NO2) on interferon (IFN) production in mice. Mice were exposed to either 5.0 ppm for 7 days or 25 ppm for 3 days followed by an i.p. injection with the IFN inducer, polyinosinic-polycytidilic acid (poly I:C). Sera and organ homogenates made from spleens and lungs were assayed for IFN. There were no significant differences in IFN levels between control and NO2 exposed mice. This was also true for isolated spleen cells from mice that were exposed in vitro to poly I:C. Under the conditions employed, it can be concluded that NO2 did not alter IFN production.
D000818:Animals; D005260:Female; D007372:Interferons / Q000096:biosynthesis*; D008168:Lung / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D011070:Poly I-C / Q000494:pharmacology; D013154:Spleen / Q000378:metabolism
D007372:Interferons; D011070:Poly I-C; D009585:Nitrogen Dioxide