title: [Immunomodulating action of levamisole in its combined use with influenza vaccines].
abstract: The immunomodulatory effect of levamisole used in combination with influenza vaccines was studied in young and senile subjects. Levamisole activated antibody production in young subjects in response to administration of a live influenza A (H3N2) vaccine and enhanced the protective effect of vaccinations. The senile subjects vaccinated with inactivated influenza A vaccine (H3N2 and H1N1) had a good immune response and the use of levamisole was not reflected in antibody rises. At the same time, levamisole alone stimulated antibody production to influenza A and B viruses which might be due to irritation of immunocompetent cells carrying "immunological memory".
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D007372:Interferons / Q000097:blood; D007978:Levamisole / Q000276:immunology / Q000627:therapeutic use*; D008297:Male; D010919:Placebos
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D010919:Placebos; D007978:Levamisole; D007372:Interferons
vernacular_title: Immunomoduliruiushchee deĭstvie levamizola pri ego sochetannom primenenii s grippoznymi vaktsinami.