The effect of memantine on various neurobiological processes.
Experiments are reported which show that 1,3-dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) does not influence the binding capacity of a variety of tritiated ligands to rat brain membranes thus suggesting that the drug does not interact with dopamine, opioid, GABA, alpha 1- and alpha 2-adrenergic receptors, but can influence with low potency 5-HT1 receptors. Autoradiographical studies also show that memantine does not interfere with the specific uptake mechanism of various transmitter substances nor is 3H-memantine taken up by any neuronal elements. Memantine at high concentrations was shown to release 3H-monoamines which had previously been taken up by nervous tissue but the release process is independent of calcium ions and is not dose-dependent. The latter effect could be explained by CNS culture studies which show memantine to produce morphological changes in neurones and glia when present at concentrations greater than 50 mumol/l.
D000547:Amantadine / Q000031:analogs & derivatives*; D000818:Animals; D001345:Autoradiography; D001667:Binding, Competitive; D001679:Biogenic Amines / Q000378:metabolism; D002478:Cells, Cultured; D007120:Immunochemistry; D008297:Male; D008559:Memantine / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism; D013373:Substance P / Q000378:metabolism
D001679:Biogenic Amines; D018377:Neurotransmitter Agents; D012701:Serotonin; D013373:Substance P; D013134:Spiperone; D000547:Amantadine; D011188:Potassium; D008559:Memantine