title: Effect of early unilateral visual deprivation on cholinergic muscarinic receptors and acetylcholinesterase in chick optic lobe.
abstract: Chicks of 1-8 days after hatching were submitted to unilateral visual deprivation and, in both optic lobes, muscarinic receptors, labeled with L-[3H]quinuclidinyl benzylate [( 3H]L-QNB) and acetylcholinesterase (AChE) were assayed. Between 1 and 6 days the number of [3H]L-QNB binding sites was lower in the contralateral optic lobe; the AChE underwent a drastic reduction (-42% at 2 days); later on the differences became not significant. The pre- and postsynaptic localization of the two cholinergic markers and the possible influence of light on axonal transport are discussed.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001370:Axonal Transport; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012683:Sensory Deprivation / Q000502:physiology*; D013997:Time Factors; D014785:Vision, Ocular / Q000502:physiology*; D014795:Visual Pathways / Q000378:metabolism*
chemical_list: D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D000110:Acetylcholinesterase