Immuno-cross-reactivity between alpha-macroglobulins from pig, dog, rat and man including human pregnancy-associated alpha 2-glycoprotein.
The antigenic relationships between the alpha-macroglobulins in human blood plasma and in serum from pig, dog and rat were investigated using ordinary immunoelectrophoresis and line immunoelectrophoresis. The results imply that these alpha-macroglobulins are more or less antigenically related. This is true also for human pregnancy-associated alpha 2-glycoprotein which is the only alpha-macroglobulin without reported proteinase-inhibiting properties. Among the alpha-macroglobulins a reciprocal cross-reactivity was observed for eight pairs, indicating a close structural relationship.
D000818:Animals; D003429:Cross Reactions; D004285:Dogs; D000939:Epitopes / Q000032:analysis; D005260:Female; D006801:Humans; D007106:Immune Sera; D007122:Immunoelectrophoresis; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000276:immunology*; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013552:Swine; D000511:alpha-Macroglobulins / Q000276:immunology*
D000939:Epitopes; D007106:Immune Sera; D011257:Pregnancy Proteins; D000511:alpha-Macroglobulins