Pulmonary veno-occlusive disease due to bleomycin therapy for lymphoma. Case reports.
Two patients with lymphocytic lymphoma and bleomycin-induced pulmonary toxicity were shown at autopsy to have pulmonary venular alterations identical to pulmonary veno-occlusive disease (PVOD). While hepatic veno-occlusive disease due to alkylating agents has been reported, I am unaware of any report of PVOD related to bleomycin therapy.
D000328:Adult; D001761:Bleomycin / Q000009:adverse effects*; D003251:Constriction, Pathologic / Q000139:chemically induced; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011667:Pulmonary Veins / Q000187:drug effects / Q000473:pathology*; D013927:Thrombosis / Q000139:chemically induced*; D014699:Venules / Q000473:pathology
D001761:Bleomycin