Effect of two graded doses of whole-body X-irradiation and radioprotection by the use of S-phenethyl formamidino 4(N-ethyl isothioamide) morpholine dihydrochloride.
The protection offered by a newly synthesized compound (S-phenethyl-formamidino-4(N-ethyl isothioamide) morpholine dihydrochloride) against radiation effects on DNA, RNA and protein biosynthetic processes in the brain, and on metabolites of 5-HT and nor-adrenalin, i.e., 5-HIAA and VMA, in the urine, including the radiobiological damage to thyroid and testes, was evaluated. The use of the compound prior to irradiation prevented radiation-induced changes in the thyroid and testes. The radiation-induced alterations in the pattern of DNA, RNA, protein in the brain, and in 5-HIAA and VMA in urine could be averted by treatment with this compound prior to each dose of X-irradiation.
D000818:Animals; D001923:Brain Chemistry; D004247:DNA / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011859:Radiography; D051381:Rats; D013737:Testis / Q000000981:diagnostic imaging; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D009025:Morpholines; D011506:Proteins; D011837:Radiation-Protective Agents; D006897:Hydroxyindoleacetic Acid; D004247:DNA; C039808:S-phenethylformamidino-4-(N-ethylisothioamide)morpholine