Drug eruptions: causative agents and clinical types. A series of in-patients during a 10-year period.
A series of 446 inpatients with drug eruption was studied to determine the causative agent and the clinical type. In over a half of the cases a provocation test confirmed the drug responsible for the reaction. Sulphonamides/trimethoprim and ampicillin/penicillin followed by phenazones were the most frequent agents causing eruptions. Sulphonamides were also the most common drugs inducing Lyell's and Stevens-Johnson syndromes. Phenazones and barbiturates were the main causes of fixed eruptions. The frequency of inpatients having drug eruption was decreased in the 1971-80 series compared with the earlier one from 1961-70. Also the frequency of Lyell's and Stevens-Johnson syndromes was lower in the latter decade than in the earlier one.
D000667:Ampicillin / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D001463:Barbiturates / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D010406:Penicillins / Q000009:adverse effects; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced; D013449:Sulfonamides / Q000009:adverse effects; D014295:Trimethoprim / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D001463:Barbiturates; D010406:Penicillins; D013449:Sulfonamides; D000667:Ampicillin; D014295:Trimethoprim