[The effect pf antacids on the tissue histamine and prostaglandin (PGE2) content of the gastric mucosa].
Stimulation tests (pentagastrin) induced significant changes in tissue histamine levels in the gastric mucosa within 30 minutes. Acid secretion and a decrease of histamine after application of antacids containing calcium could not be observed in our study; neither was application of antacids over a period of eight days followed by a change in gastric mucosal tissue histamine concentrations. Patients under non-steroidal antiphlogistic medication showed diminished histamine levels. Administration of antacids did not produce changes in histamine levels, but induced a rise of PGE2 levels in the fundal and corpus area of the stomach. This may be due to a cytoprotective effect of antacids containing calcium on the gastric mucosa.
D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D001706:Biopsy; D002118:Calcium / Q000494:pharmacology; D002986:Clinical Trials as Topic; D015232:Dinoprostone; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000032:analysis*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D010418:Pentagastrin; D011458:Prostaglandins E / Q000032:analysis*
D000863:Antacids; D011458:Prostaglandins E; D006632:Histamine; D010418:Pentagastrin; D015232:Dinoprostone; D002118:Calcium
Die Wirkung von Antazida auf den Gehalt von Gewebshistamin und Prostaglandinen (PGE2) in der Magenmukosa.