Basophil histamine release and humoral changes during immunotherapy. Dissociation between basophil-bound specific IgE, serum value, and cell sensitivity.
An in vitro pilot study was performed to determine whether basophil cell-bound specific IgE was correlated to serum-specific IgE and to basophil cell sensitivity during immunotherapy with a well-documented treatment. The findings showed a clear dissociation between these three parameters, which is in contrast to the situation before hyposensitization and to our previous study in a comparable group of non-hyposensitized patients, where highly significant correlations were observed. Further investigations are in progress to clarify whether the dissociation is involved in the clinical improvement.
D000485:Allergens / Q000008:administration & dosage; D000917:Antibody Formation; D000918:Antibody Specificity; D001491:Basophils / Q000276:immunology*; D006636:Histamine Release; D006801:Humans; D007158:Immunologic Techniques; D007167:Immunotherapy; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy
D000485:Allergens; D017455:Receptors, IgE; D011971:Receptors, Immunologic