[Dynamics of the formation of staphylococcal antigen-specific lymphocytes in the lymphoid organs of mice after subcutaneous and intravenous immunization].
The immunization of mice with heat-killed staphylococci made in a single subcutaneous injection does not induce any perceptible changes in the number of antigen-binding cells (ABC), specific to staphylococci, in the lymphoid organs and any increase in the titer of serum antibodies. As the result of immunization in a single intravenous injection, the number of ABC in the spleen rapidly increases, reaching its maximum in 4 days after immunization, and then gradually decreases, reaching the control level in 2 weeks. The occurrence of ABC in the marrow drops sharply during the first 2-4 days after immunization, then starts to rise slowly, reaching the initial level in 3-4 weeks. The single intravenous injection of staphylococci induces a rapid increase in the titer of antistaphylococcal serum IgM.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D007114:Immunization / Q000379:methods; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008214:Lymphocytes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D013211:Staphylococcus aureus / Q000276:immunology*; D013997:Time Factors
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000939:Epitopes
Dinamika formirovaniia spetsificheskikh k antigenam stafilokokka limfotsitov v limfoidnykh organakh mysheĭ posle podkozhnoĭ i vnutrivennoĭ immunizatsii.