Retinoblastoma: tissue culture lines and monoclonal antibody studies.
Retinoblastoma patients have cellular and humoral reactivity towards antigens expressed on retinoblastoma cells. We report the ultrastructural, cytogenetic, and immunologic features of four new retinoblastoma derived tissue culture cell lines. Studies with hybridoma produced monoclonal antibodies demonstrate that these lines share antigens with a previously described long-term allogeneic retinoblastoma derived tissue culture cell line, as well as with antigens on fresh retinoblastoma.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002460:Cell Line; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000032:analysis; D005134:Eye Neoplasms / Q000276:immunology* / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007111:Immunity, Cellular; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D012175:Retinoblastoma / Q000276:immunology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D000939:Epitopes; D006680:HLA Antigens