The crypto-OH radical in the damage of DNA by bleomycin-Fe2+?
1. Effects of various OH scavengers, superoxide dismutase and catalase on the formation of malondialdehyde-like products from DNA by bleomycin-Fe2+ were studied. In no case was a protective effect observed. 2. These results can be interpreted on the basis that a crypto-OH radical mediates the damage to DNA by bleomycin-Fe2+.
D001761:Bleomycin / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA; D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical; D006900:Hydroxylation; D010100:Oxygen
D005609:Free Radicals; D006878:Hydroxides; C023503:iron bleomycin; D001761:Bleomycin; D017665:Hydroxyl Radical; D004247:DNA; D010100:Oxygen