Immunological cross-reactivity of the histidine-rich protein of Plasmodium lophurae and the knob protein of Plasmodium falciparum.
Rabbits were immunized with the histidine-rich protein (HRP) of the avian malaria parasite, Plasmodium lophurae. The anti-HRP immunoprecipitated the knob protein (KP) from extracts of the human parasite, Plasmodium falciparum. The anti-HRP did not react with any antigens of a laboratory-derived strain of P. falciparum (K-) that does not form knobs. Antisera raised against a membrane-enriched fraction of P. falciparum-infected erythrocytes as well as sera from humans exposed to P. falciparum infections immunoprecipitated HRP from P. lophurae extracts.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes; D010961:Plasmodium / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D011233:Precipitin Tests; D011506:Proteins / Q000276:immunology*; D013045:Species Specificity; D000099053:Histidine-Rich Glycoprotein
D000941:Antigens; D000939:Epitopes; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein