[Effect of a blockade of the beta 1-adrenoreceptors on the hemodynamics, oxygen tension and sodium reabsorption in the rat kidney].
Blockade of kidneys' beta-1 adrenoreceptors with talinolol entailed in anesthetized rats a sodium- uretic response accompanied by inhibition of sodium reabsorption and an increase of the blood flow in cortical and external layers with no PO2 changes, at that. Haloperidol prevented the increase of blood flow in the external layer but did not affect the cortical hemodynamic shift or the depressing influence of talinolol on the channel transport of sodium. The inhibiting agent for the kallikrein-kinin system contrical and the inhibiting agent for prostaglandin synthesis indomethacin did not alter the kidney response to the drug under study. The hemodynamic shift as well as the inhibition of sodium reabsorption seem to be unrelated either to excitation of receptors sensitive to dopamine, or to activation of the kallikrein-kinin system or stimulation of prostaglandin synthesis.
D000042:Absorption; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology; D012964:Sodium / Q000378:metabolism*
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; C011550:talinolol; D007611:Aprotinin; D012964:Sodium; D006220:Haloperidol; D007213:Indomethacin
Vliianie blokady beta 1-adrenoretseptorov na gemodinamiku, napriazhenie kisloroda i reabsorbtsiiu natriia v pochke krysy.