Testosterone metabolism by homogenates of human prostates with benign hyperplasia: effect of tissular concentrations of zinc, magnesium and copper.
Zinc, magnesium and copper concentrations were measured in homogenates of 20 human prostates with benign hyperplasia and a significant direct relationship between zinc and magnesium contents was found. Activities of the testosterone-5 alpha-reductase in the same homogenates were not significantly changed according to the concentrations of the three metals but activities of the 3 alpha- and 3 beta-hydroxysteroid dehydrogenases were inversely related with the zinc concentrations of the tissue preparations. This inverse relationship may explain the known increased 5 alpha-dihydrotestosterone content in prostatic tissues with high zinc concentrations.
D015096:3-Hydroxysteroid Dehydrogenases / Q000032:analysis; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000032:analysis; D003300:Copper / Q000032:analysis*; D006801:Humans; D008274:Magnesium / Q000032:analysis*; D008297:Male; D011467:Prostate / Q000032:analysis; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*; D015032:Zinc / Q000032:analysis*
D013739:Testosterone; D003300:Copper; D015096:3-Hydroxysteroid Dehydrogenases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D008274:Magnesium; D015032:Zinc