New derivatives of blue dextran binding and stabilizing human or mouse interferons.
Mouse or human interferons were found to bind strongly to Blue Dextran 2000 and its eight new derivatives (compound VII to XIV covalently bound to Dextran 2000). The congeners of BD were pale violet or grey. The affinity of Blue Dextran and its congeners to interferons were: IFN-beta greater than IFN-alpha greater than IFN-gamma. The carriers stabilized the antiviral activity of beta-type of interferon during storage at 4 degrees C.
D000818:Animals; D004396:Coloring Agents / Q000378:metabolism*; D003911:Dextrans / Q000378:metabolism*; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007370:Interferon Type I / Q000378:metabolism* / Q000633:toxicity; D007371:Interferon-gamma / Q000378:metabolism* / Q000633:toxicity; D007700:Kinetics; D051379:Mice; D011485:Protein Binding; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D004396:Coloring Agents; D003911:Dextrans; D007370:Interferon Type I; D007371:Interferon-gamma; C017080:blue dextran