title: Variations in the 5-hydroxy-indoleacetic acid concentration in the cerebrospinal fluid during the sleep-wake cycle in man.
abstract: A variation in the ventricular fluid 5-HIAA concentration has been observed during the phases of the sleep-wake cycle in man. This variation affects the NREM phase, during which 5-HIAA increases markedly, rather than the waking state and the REM phase. The results are discussed in relation to the possible relevance of serotonin to the sleep mechanism.
mesh_terms: D000293:Adolescent; D000328:Adult; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*
chemical_list: D006897:Hydroxyindoleacetic Acid