title: [Histochemical differential diagnosis of intestinal metaplasia of the stomach--new sialic acid stains].
abstract: tients with precancerous lesions of the stomach should be followed regularly, since the prognosis of gastric carcinoma is still rather bad. A histochemical method implaying the use of sialic acid is described, which allows differentiation of two forms of intestinal metaplasia of the gastric mucosa, exhibiting possibly different degrees of premalignancy . The two types of metaplastic areas produce, respectively, duodenum-like or colon-like goblet cell mucus. Probably only the latter type is to be classified as a premalignant lesion. This hypothesis is being supported by the fact, that during histochemical work-up of routine biopsy material of gastric mucosa intestinal metaplasia of the colon type was found only in two out of twenty cases of metaplasia.
mesh_terms: D001706:Biopsy; D055598:Chemical Phenomena; D002621:Chemistry; D003937:Diagnosis, Differential; D005753:Gastric Mucosa / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D008679:Metaplasia; D010503:Periodic Acid-Schiff Reaction; D011230:Precancerous Conditions / Q000473:pathology; D012794:Sialic Acids / Q000032:analysis*; D013194:Staining and Labeling; D013270:Stomach / Q000473:pathology*
chemical_list: D012794:Sialic Acids
vernacular_title: Histochemische Differentialdiagnose intestinaler Metaplasien des Magens--Neue Sialinsäure-Färbungen.