[Kinin forming system and ovulation].
The aim of the study is to clarify the role of the kinin forming system on ovulation. The results were as follows, Plasma prekallikrein of superovulated prepubertal rats was decreased to 50-60% of the normal level after PMS injection and 80-90% of the normal level after hCG injection. The lowest level was 33.8% 39 hours after PMS injection. Aprotinin suppressed the superovulation of prepubertal rats at doses of 16.7 X 10(4) KIE and 37.8 X 10(4) KIE (p less than 0.01). These results showed that the kinin production system has an effect on ovulation. As the sex steroid hormone, estradil benzoate, progesterone and testosterone propinate were used in oophorectomized mice. They had no effect on the plasma prekallikrein level. The plasma prekallikrein level during the estrus cycle of mature female mice was 85.5% of the control level in preestrus, 80.3% in estrus, 83.7% in metestrus and 89.8% in diestrus. The mean was 83.9%, which was significantly lower than that for oophorectomized mice (94.1%). It is proved that plasma prekallikrein was consumed and the kinin forming system was accelerated in the ovary with ovulation.
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D002369:Castration; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004971:Estrus; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology; D007610:Kallikreins / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D010053:Ovary / Q000033:anatomy & histology; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011288:Prekallikrein / Q000378:metabolism*; D051381:Rats
D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D011288:Prekallikrein; D007611:Aprotinin; D007610:Kallikreins