title: [Effect of FOY-305 on the activity and secretion of pancreatic enzymes in vitro].
abstract: FOY-305, a synthetic inhibitor of serin-proteases, shows a highly specific inhibition of the activity of purified trypsin and tryptic activity from duodenal juice in a range of 1 to 10 microM. Phospholipase A2 is only partly inhibited (40%) by much higher concentrations of FOY-305 (100 microM to 1 mM), amylase activity is not affected by either concentrations. FOY-305 did not influence CCK-stimulated amylase- and trypsin-secretion from isolated pancreatic lobules in concentrations which inhibited completely tryptic activity.
mesh_terms: D000681:Amylases / Q000378:metabolism*; D000818:Animals; D002766:Cholecystokinin; D004305:Dose-Response Relationship, Drug; D004952:Esters; D016670:Gabexate / Q000031:analogs & derivatives*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000378:metabolism*
chemical_list: D004952:Esters; D006146:Guanidines; D011480:Protease Inhibitors; C034532:camostat; D016670:Gabexate; D002766:Cholecystokinin; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D000681:Amylases; D014357:Trypsin
vernacular_title: Der Einfluss von FOY-305 auf Aktivität und Sekretion von Pankreasenzymen in vitro.