[Neurogenic appendicopathy - an immunocytochemical study].
Neurogenic appendicopathy is a frequent (17.8%), non-purulent form of appendicitis. Light microscopy enabled differentiation between an intramucosal variant, a type with central neuroma and neuromuscular proliferations in the submucosa. All nerves within the gut wall were visualized independently of neurotransmitters by immunostaining for neuron-specific enolase. Proliferation of nerve fibres with substance P- and VIP-immunoreactivity was observed in the intramucosal variant and in central neuroma. Moreover, an increase was found in stromal endocrine cells with 5-hydroxy-tryptamine-, somatostatin- and substance P-immunoreactivity. These endocrine stroma cells are considered to be the site of origin of appendix carcinoids. We, therefore, suggest that appendix carcinoids originate in-frequently multicentric-foci of small endocrine cell groups localized within proliferating nerve fibres in the subepithelial stroma, independent of the epithelial layer.
D000918:Antibody Specificity; D001065:Appendix / Q000276:immunology*; D002429:Cecal Diseases / Q000276:immunology; D005934:Glucagon / Q000276:immunology; D006651:Histocytochemistry; D006801:Humans; D007106:Immune Sera / Q000032:analysis; D007120:Immunochemistry; D009037:Motilin / Q000276:immunology; D009412:Nerve Fibers / Q000276:immunology; D009463:Neuroma / Q000276:immunology; D009496:Neurotensin / Q000276:immunology; D010191:Pancreatic Polypeptide / Q000276:immunology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012701:Serotonin / Q000276:immunology; D013004:Somatostatin / Q000276:immunology; D013373:Substance P / Q000276:immunology; D014660:Vasoactive Intestinal Peptide / Q000276:immunology
D007106:Immune Sera; D012701:Serotonin; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin; D013004:Somatostatin; D009037:Motilin; D010191:Pancreatic Polypeptide; D005934:Glucagon; D010751:Phosphopyruvate Hydratase
Die neurogene Appendikopathie. Immunzytochemische Untersuchung.