Experimental and immunohistochemical studies concerning the major origins of the substance P-containing fibers in the lateral lemniscus and lateral parabrachial area of the rat, including the fiber pathways.
The origins and pathways of substance P-containing fibers in the lateral lemniscus and lateral parabrachial area of the rat were investigated by means of the indirect immunofluorescence technique. Following the placement of various knife cuts or lesions, the following could be concluded: (1) The cells of origin of substance P-containing fibers in the lateral lemniscus and lateral parabrachial area are localized in the ventral reticular formation of the rhombencephalon from the level of P2.8 to P7.0 in the atlas of Palkovits and Jacobowitz; (2) The fibers from these origins pass the ventral reticular formation of the rhombencephalon to form a dense bundle; (3) the fibers turn dorsally at the mid-rhombencephalon junction to reach the lateral lemniscus and lateral parabrachial area. The present study demonstrates the linking of the functions of the parabrachial area and lateral lemniscus via substance P innervation.
D000818:Animals; D001921:Brain / Q000276:immunology / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D008297:Male; D008636:Mesencephalon / Q000502:physiology*; D009412:Nerve Fibers / Q000276:immunology / Q000502:physiology*; D051381:Rats; D013373:Substance P / Q000276:immunology / Q000502:physiology*; D014018:Tissue Distribution
D013373:Substance P