Schistosoma mansoni: antigenic community between schistosomula surface and adult worm incubation products as a support for concomitant immunity.
The use of protective monoclonal antibodies has enabled us to demonstrate antigenic community between a 38-kDa schistosomula surface molecule and a 115-kDa component derived from adult worms. Injection of adult worms in rats also led to the production of antibodies specific for the 38-kDa antigen, suggesting that the 115-kDa adult worm molecule could act as an inducer of the protective immune response raised against young invading parasites.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology; D000917:Antibody Formation; D000954:Antigens, Surface / Q000302:isolation & purification; D006224:Cricetinae; D003902:Detergents; D004195:Disease Models, Animal; D000939:Epitopes; D007074:Immunoglobulin G / Q000276:immunology; D008647:Mesocricetus; D051381:Rats; D012550:Schistosoma mansoni / Q000276:immunology*; D012552:Schistosomiasis / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D003902:Detergents; D000939:Epitopes; D007074:Immunoglobulin G