title: Intranuclear localization of histone acetylation in Physarum polycephalum and the structure of functionally active chromatin.
abstract: Based on studies of histone acetylation in vivo in Physarum polycephalum, we present the following hypotheses: (1) Transcription-specific histone acetylation on histones H3 and H4 is a localized process at the nuclear matrix; (2) Histone acetylation in the S phase, which is specific for newly synthesized histones, occurs in an intranuclear nonlocalized process. These hypotheses can explain: (1) the histone specificity of histone acetylation that is dependent on the functional state of the chromatin; (2) the apparent absence of turnover of histone acetylation in the bulk of the chromatin despite a definite low level of steady-state acetylation of all four core histones in bulk chromatin; (3) the pattern of butyrate-induced hyperacetylation observed for active and inactive chromatin.
mesh_terms: D000085:Acetates / Q000378:metabolism; D000107:Acetylation; D002467:Cell Nucleus / Q000502:physiology*; D002843:Chromatin / Q000502:physiology*; D004261:DNA Replication; D006657:Histones / Q000302:isolation & purification / Q000378:metabolism*; D007399:Interphase; D010804:Physarum / Q000502:physiology*; D014158:Transcription, Genetic; D014316:Tritium
chemical_list: D000085:Acetates; D002843:Chromatin; D006657:Histones; D014316:Tritium