Forskolin inhibits tension development in detergent-treated cardiac muscle fibers.
In detergent-treated cardiac muscle fibers, forskolin, a potent activator of adenylate cyclases, inhibits tension development elicited with submaximal [Ca2+] and increases incorporation of 32P into troponin-I. A similar reduced tension development has been observed after treatment with cAMP or the catalytic subunit of the cAMP-dependent protein kinase. It is concluded that these fibers still contain much of the enzyme cascade involved in evoking a contractile response to beta-adrenergic stimulation.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology; D005576:Colforsin; D000242:Cyclic AMP / Q000378:metabolism; D003902:Detergents / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D014336:Troponin / Q000378:metabolism; D019210:Troponin I
D002316:Cardiotonic Agents; D003902:Detergents; D004224:Diterpenes; D014336:Troponin; D019210:Troponin I; C017474:Lubrol WX; D005576:Colforsin; D011092:Polyethylene Glycols; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D002118:Calcium; D015056:1-Methyl-3-isobutylxanthine