title: Definition of benign versus malignant ventricular arrhythmias: targets for treatment.
abstract: The most important characteristics of arrhythmias that determine the need for treatment are the prevalence and clinical significance of the ventricular arrhythmia. Ventricular arrhythmias occur more frequently with advancing age, severity of heart disease and ventricular hypertrophy. Malignant ventricular arrhythmias are of 3 forms: out-of-hospital ventricular fibrillation (VF), recurrent sustained ventricular tachycardia and torsades de pointes ventricular tachycardia in the long QT syndrome. Each condition has a high 1-year mortality rate. Potentially malignant ventricular arrhythmias are ventricular premature complexes (VPCs) of greater than 10 per hour 10 to 16 days after acute infarction and repetitive VPCs. The most malignant arrhythmias occur with severely depressed ventricular function, but VPCs alone have independent prognostic significance. Benign ventricular arrhythmias occur in patients without known heart disease and do not require treatment. The exact effect of frequent and complex VPC in these patients needs further definition.
mesh_terms: D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D001294:Attitude to Health; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D004562:Electrocardiography; D006323:Heart Arrest / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D005082:Physical Exertion; D013610:Tachycardia / Q000503:physiopathology