[Correlation between serum IgE level and human basophil degranulation by anti-IgE antibodies].
The human basophil degranulation test (HBDT) by anti-IgE antibodies was applied in 3 groups of subjects: 20 controls, 26 patients with helminthiasis and 28 allergic patients. Mean degranulation was higher in patients with helminthiasis than in the two other groups. A correlation was found between IgE serum level and HBDT results by anti-IgE (r = 0.373; p less than 0.02) with Spearman's rank correlation test. Therefore, degranulation with anti-IgE antibodies would appear to depend on the quantity of cell-bound IgE rather than on intrinsic basophil sensitivity.
D000888:Antibodies, Anti-Idiotypic / Q000502:physiology*; D001491:Basophils / Q000276:immunology*; D003594:Cytoplasmic Granules / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006373:Helminthiasis / Q000276:immunology; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis* / Q000276:immunology; D008297:Male
D000888:Antibodies, Anti-Idiotypic; D007073:Immunoglobulin E
Corrélation entre le taux d'IgE sériques et la dégranulation des basophiles humains par les anticorps anti-IgE.