title: Effect of vesicular stomatitis virus (VSV) infection on the development and regulation of T cell-mediated immune responses.
abstract: Infection of mice with vesicular stomatitis virus (VSV) at the time of immunization failed to enhance T cell-mediated immune response to azobenzenearsonate-(ABA) conjugated spleen cells as measured by delayed-type hypersensitivity and by in vitro proliferation and in vitro generation of ABA-specific cytotoxic T cells. However, mice infected with VSV are incapable of responding to signals from suppressor T cells or their soluble factors. Further analysis revealed that VSV infection does not interfere with the induction of Ts-1 or Ts-2 cells. Because infection of Ts-1 or Ts-2 donors had no effect on the subsequent response seen in the recipients of antigen and suppressor T cells, the most likely candidate for the target of VSV infection is therefore the Ts-3 cell or another T cell interacting with Ts-3. This is supported by our observation that it is possible to bypass the VSV effect by providing the recipients of VSV with normal Lyt-2+-bearing T cells.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000008:administration & dosage / Q000276:immunology; D001391:Azo Compounds / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007130:Immunoglobulin Idiotypes / Q000096:biosynthesis / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*; D010132:p-Azobenzenearsonate / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D001391:Azo Compounds; D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D010132:p-Azobenzenearsonate