[Behavior of blood pressure and substance P-like immunoreactivity (SPLIR) in plasma of rats with genetically fixed hypertension (SHR) under chronic intermittent immobilization].
The influence of chronic immobilization on blood pressure and on substance P-like immunoreactivity (SPLIR) in blood plasma was examined in 11-week-old male spontaneously hypertensive rats (SHR) and male normotensive Wistar Kyoto rats (WKY). In SHR chronic immobilization caused a stop of the genetically fixed development of hypertension at the level already reached. Also, SPLIR in blood plasma was lower compared with a SHR control group without immobilization. In WKY rats chronic immobilization has no influence on blood pressure and SPLIR. The observed variations in SPLIR and blood pressure under the influence of chronic immobilization is discussed in relation to a possible function of substance P in the development of hypertension.
D000818:Animals; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*; D013373:Substance P / Q000097:blood*; D013997:Time Factors
D013373:Substance P
Verhalten von Blutdruck und "Substance P-like immunoreactivity" (SPLIR) im Plasma von Ratten mit genetisch fixierter Hypertonie (SHR) unter chronisch intermittierender Immobilisation.