A case of juvenile erythroleukemia with uncoordinated expression of fetal red cell markers.
A 7-year-old boy with juvenile erythroleukemia is described, whose red cells demonstrated a high content of Hb F with fetal structure and yet contained carbonic anhydrase at adult red cell level. The findings seem to exemplify the occurrence of uncoordinated expression of fetal markers and consequently the incomplete reversion to fetal-type erythropoiesis in a hematologic malignancy.
D002256:Carbonic Anhydrases / Q000097:blood*; D002648:Child; D004912:Erythrocytes / Q000201:enzymology; D005319:Fetal Hemoglobin / Q000032:analysis*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood*; D008297:Male
D005319:Fetal Hemoglobin; D002256:Carbonic Anhydrases