[Synthesis of phenol-antigen conjugates by reacting N-hydroxysuccinimidic esters of hydroxybenzoic acids with human serum albumin and bovine gamma globulin].
Salicylic acid, beta-resorcylic acid and gentisic acid were acetylated and then reacted with N-hydroxysuccinimide according to the DDC procedure to give the corresponding activated esters. The reaction of these N-hydroxysuccinimidic esters with human serum albumin and bovine gamma globulin yielded modified proteins containing hydroxybenzoyl residues linked to amino groups, the mode of linkage being of the acid amide type.
D000107:Acetylation; D000818:Animals; D000941:Antigens; D002417:Cattle; D005841:Gentisates; D006801:Humans; D062385:Hydroxybenzoates / Q000276:immunology*; D010636:Phenols; D012459:Salicylates / Q000276:immunology; D020156:Salicylic Acid; D012709:Serum Albumin; D013388:Succinimides / Q000276:immunology; D005719:gamma-Globulins
D000941:Antigens; D005841:Gentisates; D062385:Hydroxybenzoates; D010636:Phenols; D012459:Salicylates; D012709:Serum Albumin; D013388:Succinimides; D005719:gamma-Globulins; C017704:beta-resorcylic acid; D020156:Salicylic Acid; C010925:2,5-dihydroxybenzoic acid
Synthese von Phenol-Antigen-Konjugaten durch Umsetzung von N-Hyroxysuccinimidestern von Hydroxybenzoesäuren mit Humanserumalbumin und Rindergammaglobulin.