[Possibilities of using ferromagnetic materials for targeted drug transport].
Possibilities of using particles containing ferromagnetic materials and magnetic concentrated colloids for targeted drug transport have been studied. Magnetic particles produced from Sephadex G-25 by ferromagnetic material fixation, polymer-modified iron particles 100 nm in diameter, and concentrated colloid solutions of Fe3O4 are retained in the marginal ear vein of the rabbit by magnetic field at H = 0.5 kHs/cm. The data on magnetic retention of the above-indicated agents in the vein, obtained by measuring 75Se and 131I activity, of labeled particles are presented.
D000818:Animals; D003102:Colloids; D003911:Dextrans / Q000008:administration & dosage; D005290:Ferric Compounds / Q000008:administration & dosage*; D052203:Ferrosoferric Oxide; D007501:Iron / Q000008:administration & dosage*; D008280:Magnetics; D008863:Microspheres; D010087:Oxides; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011817:Rabbits
D003102:Colloids; D003911:Dextrans; D005290:Ferric Compounds; D010087:Oxides; D004364:Pharmaceutical Preparations; C001215:ferrite; C025614:sephadex; D007501:Iron; D052203:Ferrosoferric Oxide
Vozmozhnosti ispol'zovaniia ferromagnitnykh materialov dlia napravlennogo transporta lekarstv.