Psoriasis in first-degree relatives of psoriatic twins.
Analysis of the presence of psoriasis in all first-degree relatives of psoriatic twin probands, 38 monozygotic (MZ) and 24 dizygotic (DZ), has been performed in order to clarify if genetic heterogeneity might be present (the twin-family method). The probands were derived from a population based sample of like-sexed twin pairs. An almost identical frequency of psoriasis in parents, siblings and children, with no sex difference, was found. By comparisons of empirical risk figures for psoriasis in first-degree relatives of concordant as compared with discordant MZ probands and HLA-B 13 and/or HLA-B 17 positive MZ probands compared with MZ probands lacking these antigens, no clue to the presence of genetic heterogeneity was found. An almost identical risk in co-twins and ordinary siblings of DZ-probands was found. The data were incompatible with autosomal recessive or X-linked inheritance, but not incompatible with autosomal dominant inheritance with reduced penetrance or with multifactorial inheritance.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004198:Disease Susceptibility; D004200:Diseases in Twins; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015235:HLA-B Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D006680:HLA Antigens; D015235:HLA-B Antigens; C035015:HLA-B12 antigen; C037449:HLA-B17 antigen