Effect of cis and trans isomers of 1-amino-2-(p-chlorophenyl)cyclohexane, conformationally restricted analogs of p-chloroamphetamine, on 5-hydroxyindoles in rat brain.
Cis and trans isomers of 1-amino-2-(p-chlorophenyl)cyclohexane, conformationally restricted analogs of p-chloroamphetamine, did not decrease brain serotonin and 5-hydroxyindoleacetic acid concentrations at i.p. doses of .05 and .1 mmole/kg in rats, doses at which p-chloroamphetamine itself decreased the concentrations of these 5-hydroxyindoles to half or less of their initial values. These analogs of p-chloroamphetamine, unlike several others studied previously, apparently lack the ability of the parent compound to inhibit serotonin uptake or synthesis or to release serotonin from intraneuronal granular stores.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D010133:p-Chloroamphetamine / Q000494:pharmacology
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D010133:p-Chloroamphetamine