Stain intensity of human nucleolus organizer region reflects incorporation of uridine into mature ribosomal RNA.
The stain intensity of the nucleolus organizer regions (NORs) of acrocentric chromosomes was correlated positively with incorporation of [3H]uridine into 18S rRNA and 28S rRNA from cultured diploid human skin fibroblasts. An analysis of these data from twins by a path model indicated that no other common genetic or environmental parameters were required to explain the relationship between NOR scores and uptake of [3H]uridine into mature rRNA species.
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008875:Middle Aged; D009697:Nucleolus Organizer Region; D011247:Pregnancy; D012335:RNA, Ribosomal / Q000378:metabolism*; D013194:Staining and Labeling; D014430:Twins, Monozygotic; D014529:Uridine / Q000378:metabolism*
D012335:RNA, Ribosomal; D014529:Uridine