title: Developmental variations of brain serotonin, tryptophan, 5-hydroxyindole acetic acid, and noradrenaline and dopamine content in two inbred strains of mice.
abstract: Endogenous levels of tryptophan (TRP), serotonin (5-HT), 5-hydroxyindol acetic acid (5-HIAA), noradrenaline (NA) and dopamine (DA), were measured in the brain-stem and anterior regions of C57BL and BALBc mice whose ages ranged from 1 day postnatal to 12 weeks. In C57BL mice levels of NA were found to be higher in the brainstem from week 1 onwards (except at week 3), and in the anterior region from week 6 onwards than in BALBc mice. 5-HT levels were found to be higher in C57BL mice from day 1 to week 2 in the brain-stem, and in the anterior region at week 1 and from week 5 onwards, compared to BALBc. The evolution of DA levels in the anterior region shows opposite differences before and after week 3-4. Before week 3 lower levels of DA were found in C57BL mice and the reverse is observed from week 5 onwards. Moreover during the postnatal development, the variation of the different components of the serotoninergic metabolism (TRP, 5-HT, 5-HIAA) is similar to that observed in other species.
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D014644:Genetic Variation; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000378:metabolism*; D011247:Pregnancy; D012701:Serotonin / Q000378:metabolism*; D013045:Species Specificity; D014364:Tryptophan / Q000378:metabolism*
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D004298:Dopamine; D009638:Norepinephrine