[Effect of deficiency and excess of thyroid hormones in the body on indolamine metabolism in the rat epiphysis cerebri].
Thyroid hormones were demonstrated to play a role in serotonin metabolism control in pinealocytes. Saturation of the body with T4 shifts the process of serotonin utilization toward acetylation and subsequent ortho-methylation with primary formation of N-acetylserotonin and melatonin while total thyroidectomy blocks this process to a considerable degree. Under deficiency of thyroid hormones the pathway of oxidative serotonin deamination with primary formation of 5-hydroxyindole-acetic acid is the predominant one. Excess and deficiency of thyroid hormones produce opposite effects in the epiphysis. The data obtained not only support the presence of the negative feed-back in the epiphysis-thyroid system but also emphasize that the process of formation of epiphyseal methoxyindoles is the most sensitive one to the action of thyroid hormones.
D008735:5-Methoxytryptamine / Q000378:metabolism; D000818:Animals; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D006980:Hyperthyroidism / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000378:metabolism; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism
D007211:Indoles; D012701:Serotonin; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid; D008550:Melatonin; C006389:N-acetylserotonin
Vliianie nedostatka i izbytka tireoidnykh gormonov v organizme na metabolizm indolaminov v épifizakh krys.