A mechanism that couples DNA transposition to cell differentiation (hypothesis).
A hypothesis underlying the significance of cytoplasmic events in the process of DNA transposition is proposed. To appear at a new chromosomal site, the transposon sequence is assumed to be first transcribed and then, in a form of the RNA copy, transported to the cytoplasm. A translation-dependent selection of RNA transcripts for reverse transcription is then made and the resulting single-stranded DNA copies return to the nucleus. The free copy may integrate within a new, transcriptionally inactive region of the chromosomal DNA. As a net result, cell differentiation advances in a manner coupled to the message utilization. The hypothesis finds support in many observations, particularly those made for plant cells.
D002454:Cell Differentiation; D004247:DNA / Q000235:genetics; D004251:DNA Transposable Elements; D005786:Gene Expression Regulation; D012194:RNA-Directed DNA Polymerase / Q000235:genetics; D011995:Recombination, Genetic
D004251:DNA Transposable Elements; D004247:DNA; D012194:RNA-Directed DNA Polymerase