title: Recent advances in metal carcinogenesis.
abstract: Recent advances in metal carcinogenesis are comprehensively reviewed, including (a) epidemiological and clinical aspects, (b) carcinogenesis bioassays, (c) bacterial mutagenesis, (d) mammalian cell mutagenesis, (e) chromosomal damage, (f) mammalian cell transformation, (g) microsomal metabolism, (h) DNA strandbreaks and crosslinks, (i) DNA polymerase infidelity, (j) RNA strand initiation, and (k) helical transition of B-DNA to Z-DNA. Based upon these observations, several hypotheses are proposed for the molecular pathogenesis of carcinogenesis by metal compounds. These hypotheses are amenable to experimental test by existing techniques of molecular biology.
mesh_terms: D000818:Animals; D001151:Arsenic / Q000009:adverse effects; D002104:Cadmium / Q000009:adverse effects; D002274:Carcinogens, Environmental; D002412:Cations / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D002857:Chromium / Q000009:adverse effects; D002875:Chromosomes / Q000187:drug effects; D003432:Cross-Linking Reagents; D004247:DNA / Q000378:metabolism; D004572:Electrolysis; D005260:Female; D006801:Humans; D008297:Male; D008669:Metallurgy; D008670:Metals / Q000009:adverse effects*; D009152:Mutagenicity Tests; D009153:Mutagens; D009369:Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009532:Nickel / Q000009:adverse effects; D009698:Nucleoproteins / Q000378:metabolism; D009784:Occupational Diseases / Q000139:chemically induced*; D010984:Platinum / Q000009:adverse effects; D012313:RNA / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D002274:Carcinogens, Environmental; D002412:Cations; D003432:Cross-Linking Reagents; D008670:Metals; D009153:Mutagens; D009698:Nucleoproteins; D002104:Cadmium; D002857:Chromium; D010984:Platinum; D012313:RNA; D009532:Nickel; D004247:DNA; D001151:Arsenic