title: Mucinous tumors of the ovary with argyrophil cells. An immunohistochemical analysis.
abstract: Forty-five cases of mucinous tumors of the ovary were studied for argyrophilia. Argyrophil cells were identified in seven of the 22 cystadenomas (32%), five of the 11 borderline tumors (45%), and two of the 12 carcinomas (17%). These 14 tumors and two additional mucinous tumors known to contain argyrophil cells were studied further by immunohistochemical methods for the localization of calcitonin, gastrin, somatostatin, adrenocorticotropin (ACTH), serotonin, neurotensin, and lysozyme. Serotonin immuno-reactivity was identified in 15 of the 16 cases. Among the peptide hormones, there was a high frequency of positivity for ACTH, gastrin, and somatostatin. Despite the demonstration of reactivity for these hormones, there was no clinical evidence of syndromes of hormone excess in the patients. Lysozyme was present in all but one of the benign and borderline tumors, but was not identified in the carcinomas. Lysozyme was also found in normal and neoplastic gastric and endocervical epithelium, indicating that its presence is not useful in differentiating gastrointestinal and müllerian-type epithelium. The results of this study confirm the previously recognized intestinal characteristics of the epithelium of many mucinous tumors, but also raise the question whether the simple, uniformly mucinous epithelium that is most common within these tumors and is generally regarded as endocervical in type may occasionally be gastric in nature.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000032:analysis; D002116:Calcitonin / Q000032:analysis; D003536:Cystadenocarcinoma / Q000032:analysis / Q000473:pathology*; D003537:Cystadenoma / Q000032:analysis / Q000473:pathology*; D004727:Endothelium / Q000473:pathology; D005260:Female; D005755:Gastrins / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D009113:Muramidase / Q000032:analysis; D009496:Neurotensin / Q000032:analysis; D010051:Ovarian Neoplasms / Q000032:analysis / Q000473:pathology*; D012701:Serotonin / Q000032:analysis; D012834:Silver; D013004:Somatostatin / Q000032:analysis; D013194:Staining and Labeling
chemical_list: D005755:Gastrins; D012701:Serotonin; D009496:Neurotensin; D012834:Silver; D013004:Somatostatin; D000324:Adrenocorticotropic Hormone; D002116:Calcitonin; D009113:Muramidase