title: Evaluation of hypotensive mechanisms of captopril in addition to its inhibition of the converting enzyme in spontaneously hypertensive rats.
abstract: In spontaneoulsy hypertensive rats (SHR), the hypotensive effect of captopril (30 mg/kg/day per os for 4 days), which inhibits the converting enzyme when given orally was significantly potentiated rather than suppressed by aprotonin (100,000 KIU/day s.c. for 7 days), but was not affected by indomethacin. These findings suggest that neither the kallikrein-kinin system nor the prostaglandin system is involved in any of the hypotensive actions of captopril in SHR other than the inhibition of the converting enzyme.
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D011453:Prostaglandins / Q000502:physiology; D051381:Rats
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D011453:Prostaglandins; D007611:Aprotinin; D011392:Proline; D002216:Captopril; D007213:Indomethacin