Presence of a Kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene.
Oncogenes have previously been reported in the DNAs of mouse fibroblast lines which had become transformed after in vitro exposure to the carcinogen 3-methylcholanthrene. These oncogenes are now shown to be versions of the cellular Kirsten ras gene and are therefore homologous to oncogenes detected in a variety of human tumor DNAs.
D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000302:isolation & purification; D004279:DNA, Viral / Q000302:isolation & purification; D005814:Genes, Viral; D007708:Kirsten murine sarcoma virus / Q000235:genetics*; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger; D009053:Sarcoma Viruses, Murine / Q000235:genetics*; D014162:Transfection; D014764:Viral Proteins / Q000302:isolation & purification
D002273:Carcinogens; D004273:DNA, Neoplasm; D004279:DNA, Viral; D012333:RNA, Messenger; D014764:Viral Proteins; D011061:Poly A; D008748:Methylcholanthrene; D012313:RNA