The effects of 1-methyl-3-isobutylxanthine on insulin-sensitive 2-deoxyglucose transport.
The effect of 1-methyl-3-isobutylxanthine on insulin-sensitive 2-deoxyglucose uptake in rat adipocytes was studied. 1-Methyl-3-isobutylxanthine inhibited 2-deoxyglucose uptake rate substantially in both the absence and presence of insulin. The lag-time for the effect of insulin on 2-deoxyglucose uptake was prolonged. At the same time 1-methyl-3-isobutylxanthine caused a decrease in ATP levels. From experiments with isolated rat liver mitochondria it appeared that 1-methyl-3-isobutylxanthine inhibits glutamate plus malate oxidation in State 3.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000031:analogs & derivatives*
D003837:Deoxy Sugars; D007328:Insulin; D000255:Adenosine Triphosphate; D003847:Deoxyglucose; D013806:Theophylline; D015056:1-Methyl-3-isobutylxanthine