Effects of cordycepin on the synthesis of nuclear and cytoplasmic RNAs in embryonic cells of Xenopus laevis.
Effects of cordycepin on the incorporation of [3H] guanosine into embryonic Xenopus cells were examined. Cordycepin inhibited the labeling not only of poly(A) + RNA, but of all the other major classes of RNAs. Cellular fractionation showed that this inhibition was much stronger in the labeling of cytoplasmic RNAs than of nuclear RNAs. [3H]Cordycepin was incorporated into both poly(A) + RNA and other RNA species.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D003839:Deoxyadenosines / Q000494:pharmacology*; D004625:Embryo, Nonmammalian; D011061:Poly A / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis* / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional / Q000187:drug effects; D014158:Transcription, Genetic / Q000187:drug effects*; D014982:Xenopus laevis
D003839:Deoxyadenosines; D011061:Poly A; D012313:RNA