title: The area of lymphocyte nucleoli (ALN) and its relationship with RNA synthesis in lymphocytes after blastic transformation in in vitro cultures.
abstract: The area of lymphocyte nucleoli (ALN) is a recently imagined method (Micu et al., 1978) which can detect cytochemically the microscopically visible surface of nucleolar RNA, measurable in mu2. The normal ALN value in peripheral blood is 84.4 +/- 9.2 mu2. Using in vitro cultures of PHA-stimulated lymphocytes obtained from 106 patients with various internal diseases, the authors could demonstrate a relationship between the rate of the lymphocytic RNA biosynthesis and the ALN variations, namely that an RNA hyper- or hyposynthesis is accompanied by an increase or a decrease, respectively, of the ALN.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology; D001249:Asthma / Q000276:immunology; D002466:Cell Nucleolus / Q000378:metabolism*; D002478:Cells, Cultured; D002908:Chronic Disease; D006505:Hepatitis / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D012313:RNA / Q000096:biosynthesis*
chemical_list: D012313:RNA