title: Proliferative responses of fibroblasts from psoriatic and normal skin to clobetasol propionate.
abstract: The proliferation of fibroblasts cultured from psoriatic and normal skin was compared following addition of clobetasol propionate to the culture medium. Proliferation was stimulated at 0.1 microgram/ml and progressively inhibited at 1-10 micrograms/ml. A differential sensitivity to the drug was demonstrated: the fibroblasts from involved psoriatic skin were more stimulated than normal fibroblasts at 0.1 microgram/ml and then more inhibited at 10 micrograms/ml. The fibroblasts from uninvolved psoriatic skin displayed intermediate responses. There was some cytotoxicity in cultures of the psoriatic cells at 10 micrograms/ml. The results demonstrate a further abnormality of fibroblasts from psoriatic skin.
mesh_terms: D001623:Betamethasone / Q000031:analogs & derivatives*; D002455:Cell Division; D002478:Cells, Cultured; D002990:Clobetasol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000473:pathology*
chemical_list: D001623:Betamethasone; D002990:Clobetasol