Uniquely, gamma-endorphin induces an effect that is both opiate- and neuroleptic-like.
Bilateral injection of gamma-endorphin into the nucleus accumbens of rats antagonizes the hyperlocomotion elicited by local treatment with relatively high doses of apomorphine. beta-Endorphin, alpha-endorphin, [Met]enkephalin, [Leu]enkephalin and des-Tyr1-gamma-endorphin do not mimic this effect of gamma-endorphin. Previous studies have shown that this antagonism by gamma-endorphin is mediated by a naloxone sensitive receptor system. It is concluded that uniquely, gamma-endorphin has an action that is both opiate- and neuroleptic-like.
D000818:Animals; D014150:Antipsychotic Agents; D001058:Apomorphine / Q000494:pharmacology*; D004336:Drug Antagonism; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009294:Narcotics; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*; D018823:gamma-Endorphin
D014150:Antipsychotic Agents; D004723:Endorphins; D004745:Enkephalins; D009294:Narcotics; D018823:gamma-Endorphin; D001058:Apomorphine