title: A cytochemical study of the effect of cholinergic and beta-adrenergic stimulation on calcium fluxes of rat parotid gland.
abstract: Parotid gland tissue from carbachol-treated and isoproterenol-treated rats was studied cytochemically by pyroantimonate precipitation and x-ray microanalysis in an effort to identify any intracellular calcium reservoirs that might be available for use in a stimulus-secretion coupling mechanism, and to determine any differences that might exist in terms of calcium utilization due to the cholinergic or beta-adrenergic receptor mechanisms. Stimulation by either secretagogue results in a reduction of mitochondrial and plasma membrane calcium, but the reduction in mitochondrial calcium deposits of carbachol-treated animals is only one-half that of the beta-adrenergic-treated animals. This could possibly suggest a greater dependency on mitochondrial calcium for beta-adrenergic stimulated animals.
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002217:Carbachol / Q000494:pharmacology; D006651:Histocytochemistry / Q000379:methods; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D010277:Parasympathomimetics / Q000494:pharmacology*; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling
chemical_list: D000318:Adrenergic beta-Agonists; D010277:Parasympathomimetics; D002217:Carbachol; D007545:Isoproterenol; D002118:Calcium