Antiviral activity of Wratizolin.
Wratizolin, the new non-steroidal anti-inflammatory drug, was found to inhibit the replication of Herpes simplex, type 1 and 2, viruses (HSV-1, HSV-2) in vitro. The selectivity of the antiviral action is low because the drug disturbs cellular metabolism. Wratizolin at the relatively low concentration (37 micrograms/ml) inactivates partially purified HSV-2 after incubation for 30 min at 37 degrees. The addition of albumin to the reaction mixture inhibits the virucidal activity of the drug. Wratizolin has little if any effect on the production and action of interferon. The drug used topically as 2% solution in dimethylsulfoxide inhibits the evolution of lesions induced in the guinea pig skin by HSV-2. However, the drug did not prevent the replication of HSV-2 in the guinea pig skin.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin / Q000494:pharmacology; D002478:Cells, Cultured; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use; D005260:Female; D005439:Flufenamic Acid / Q000494:pharmacology; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy; D007213:Indomethacin / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis / Q000494:pharmacology; D008297:Male; D008528:Mefenamic Acid / Q000494:pharmacology; D012254:Ribavirin / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects*; D013844:Thiazoles / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D013844:Thiazoles; D008528:Mefenamic Acid; D012254:Ribavirin; C027999:5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide; D005439:Flufenamic Acid; D007372:Interferons; D001241:Aspirin; D007213:Indomethacin; D004121:Dimethyl Sulfoxide