Bronchial asthma and the neutrophil chemotactic factor.
Neutrophil chemotactic factor (NCF) is a slight acidic macromolecule which is released into the circulation of asthmatic individuals following antigen provocation and an exercise task. It also appears in late asthmatic reactions with a time course of appearance which precedes the second fall in FEV1. The release of NCF was inhibited by prior administration of disodium cromoglycate (DSCG) suggesting its possible mast cell origin.
D000402:Airway Obstruction / Q000175:diagnosis / Q000209:etiology; D001249:Asthma / Q000097:blood / Q000209:etiology / Q000276:immunology*; D001250:Asthma, Exercise-Induced / Q000097:blood / Q000276:immunology; D001491:Basophils / Q000276:immunology; D001985:Bronchial Provocation Tests; D055598:Chemical Phenomena; D002621:Chemistry; D002630:Chemotactic Factors / Q000097:blood*; D002908:Chronic Disease; D005541:Forced Expiratory Volume; D006636:Histamine Release; D006801:Humans; D007249:Inflammation / Q000209:etiology; D016209:Interleukin-8
D002630:Chemotactic Factors; D016209:Interleukin-8