Initiation of angiogenesis by human follicular fluid.
Angiogenesis was observed and measured after injection of human follicular fluid into rabbit corneas. Undiluted human follicular fluid stimulated angiogenesis in every case, with new blood vessels visible 3 days after injection and extending 2.0 millimeters from the corneal scleral limbus into the injection site by day 15. Stimulation of angiogenesis was lost by heating or diluting the follicular fluid but was retained after charcoal stripping or dialysis. Human follicular fluid contains an angiogenic factor that may be associated with perifollicular neovascularization during folliculogenesis.
D043925:Angiogenesis Inducing Agents / Q000032:analysis*; D000818:Animals; D001826:Body Fluids / Q000032:analysis*; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003315:Cornea / Q000098:blood supply; D003956:Dialysis; D005260:Female; D006133:Growth Substances / Q000032:analysis*; D006358:Hot Temperature; D006801:Humans; D008598:Menstruation; D009389:Neovascularization, Pathologic; D006080:Ovarian Follicle / Q000032:analysis*; D011817:Rabbits
D043925:Angiogenesis Inducing Agents; D006063:Chorionic Gonadotropin; D006133:Growth Substances