[The effect of tetraethylammonium and the decrease in the extracellular chloride concentration on membrane depolarization and contraction of skeletal muscle fiber induced by a hyperpotassium solution].
1.--The tetraethylammonium (TEA) effects on K+ contracture and membrane depolarization are compared in both crab and frog skeletal muscle fibres. 2.--The mechanical tension of the contracture is reduced by the TEA in frog skeletal muscle fibre; it is increased in crab skeletal fibre. 3.--When no mechanical phenomenon is observed in frog skeletal muscle, the amplitude and the velocity of membrane depolarization induced by an increase of outward K+ concentration is reduced by the TEA. These effects are in opposition in crab muscle fibre. 4.--In crab muscle fibre, the results obtained tend to show that the C1-ions are not distributed on each side of the membrane according to Donnan equilibrium.
D000818:Animals; D001001:Anura; D003386:Brachyura; D002462:Cell Membrane / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*
D002712:Chlorides; D013757:Tetraethylammonium Compounds; D011188:Potassium
Influence du tétraéthylammonium et de la diminution de la concentration extracellulaire en chlore sur la dépolarisation membranaire et la contracture de la fibre squelettique induites par un milieu hyperpotassique.