Kainic acid prevents peroxidase labeling of retinal ganglion cell bodies in the rat: a possible gate in retrograde axonal transport.
Kainic acid, a neurotoxic analogue of glutamate, injected into the vitreous body of the eye, interferes with the retrograde transport of the marker enzyme horseradish peroxidase. This interference is expressed by the absence of detectable peroxidase in the cell bodies of the retinal ganglion cells and by the presence of the marker in the intraretinal portions of the optic axons. These results suggest the hypothesis of the existence of some kind of gate at the proximal portion of the axons which would control the entry of retrogradely moving material into the cell body.
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D001369:Axons / Q000032:analysis; D006735:Horseradish Peroxidase / Q000032:analysis; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009900:Optic Nerve / Q000032:analysis; D010544:Peroxidases; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D012160:Retina / Q000032:analysis / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology*
D011759:Pyrrolidines; D006735:Horseradish Peroxidase; D010544:Peroxidases; D007608:Kainic Acid