Amiodarone for refractory automatic atrial tachycardia: observations on the electrophysiological actions of amiodarone.
A patient with automatic atrial tachycardia refractory to all conventional therapies is described. Amiodarone controlled the tachycardia by causing a progressive decrease in the rate of discharge from the atrial focus. We conclude that 1) amiodarone was effective therapy for automatic atrial tachycardia, avoiding the need for nonmedical therapy; and 2) amiodarone appeared to act by decreasing spontaneous automaticity.
D000638:Amiodarone / Q000627:therapeutic use*; D001283:Atrioventricular Node / Q000187:drug effects / Q000503:physiopathology; D001572:Benzofurans / Q000627:therapeutic use*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013610:Tachycardia / Q000188:drug therapy* / Q000503:physiopathology
D001572:Benzofurans; D000638:Amiodarone