title: Intracortical termination of the retino-geniculo-striate pathway studied with transsynaptic tracer (wheat germ agglutinin-horseradish peroxidase) and cytochrome oxidase staining in the macaque monkey.
abstract: The tracer, wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP), was used as a transneuronal marker in the macaque monkey to study retino-geniculo-striate pathway terminals in area 17. Concomitantly, we stained matching sections for metabolic capacity using the cytochrome oxidase staining technique. Terminal labeling by WGA-HRP and cytochrome oxidase activity staining revealed duplicate patterns in layers II and III, IVA, IVC alpha, IVC beta, and VI. The absence of WGA-HRP-labeled neuronal cell bodies in area 17 supports the conclusion that WGA-HRP is a transsynaptic marker in the macaque visual pathways.
mesh_terms: D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D005829:Geniculate Bodies / Q000033:anatomy & histology*; D006651:Histocytochemistry; D006735:Horseradish Peroxidase; D037102:Lectins; D008252:Macaca fascicularis; D012160:Retina / Q000033:anatomy & histology*; D013194:Staining and Labeling / Q000379:methods; D014793:Visual Cortex / Q000033:anatomy & histology*; D014795:Visual Pathways / Q000033:anatomy & histology; D014909:Wheat Germ Agglutinins
chemical_list: D037102:Lectins; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase; D003576:Electron Transport Complex IV