An oncofetal 60-kilodalton protein in the plasma of tumor-bearing and carcinogen-treated rats.
A Mr 60,000 protein, detected by its ability to induce the release of RNA from isolated nuclei, is present in the plasma of tumor-bearing and carcinogen-treated rats, together with low amounts of 2 messenger RNA transport proteins identified earlier in normal cells. The Mr 60,000 protein has been identified in tumor cell cytoplasm and in amniotic fluid, but does not appear to cross the placental barrier. Significant amounts of the Mr 60,000 oncofetal protein appear in the plasma of carcinogen-treated rats within a few weeks of treatment. It may be the fetal form of the adult messenger RNA transport proteins.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000653:Amniotic Fluid / Q000032:analysis; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002850:Chromatography, Gel; D003600:Cytosol / Q000032:analysis; D005260:Female; D005326:Fetal Proteins / Q000032:analysis*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000097:blood*; D012313:RNA / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012261:Ribonucleoproteins / Q000032:analysis
D005326:Fetal Proteins; D009363:Neoplasm Proteins; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein; D015127:9,10-Dimethyl-1,2-benzanthracene; D012313:RNA