Transfer of immunological tolerance by means of RNA.
Ribonucleic acid extracts were isolated from the lymph nodes and spleens of mice bearing tolerated skin allografts for long periods after neonatal tolerance induction. Lymphoid cells from control, untreated mice were incubated in vitro with these RNA extracts and then transferred into normal newborn mice. Skin allografts applied to the RNA-treated animals tn adult life survived significantly longer when compared with the non-treated mice or mice treated with RNA extracted from normal, non-tolerant mice. The results indicate that RNA from tolerant animals, like suppressor cells, is effective in prolonging skin allograft survival.
D000818:Animals; D000831:Animals, Newborn; D007108:Immune Tolerance; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012313:RNA / Q000235:genetics*; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology; D014184:Transplantation, Homologous
D012313:RNA