Antidepressant properties of some phosphodiesterase inhibitors.
Effects of three phosphodiesterase (PDE) inhibitors (rolipram, IBMX, and Ro 20-1724) were studied in mice in some tests predictive for antidepressant activity. All the drugs antagonized reserpine-induced hypothermia and slightly antagonized reserpine-evoked hypoactivity. Rolipram and IBMX were also effective in behavioral despair test. On the other hand, the examined PDE inhibitors did not affect apomorphine-induced hypothermia and did not potentiate the central action of L-DOPA. These results show that psychopharmacological profile of the PDE inhibitors differs from that of classical imipramine-like antidepressants.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001058:Apomorphine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D020889:Rolipram
D000928:Antidepressive Agents; D010726:Phosphodiesterase Inhibitors; D011760:Pyrrolidinones; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; D012110:Reserpine; D020889:Rolipram; D001058:Apomorphine; D015056:1-Methyl-3-isobutylxanthine