The effect of poly(A) segment size on the inhibition of hnRNA biosynthesis by cordycepin in rat brain cells.
In rat brain cells low doses of cordycepin (3'-deoxyadenosine) practically do not inhibit biosynthesis of hnRNA with short 3'-terminal poly(A) segments. The same antibiotic doses are sufficient for effective inhibition of biosynthesis of hnRNA containing long poly(A) chains.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003839:Deoxyadenosines / Q000494:pharmacology*; D008297:Male; D011061:Poly A / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D012332:RNA, Heterogeneous Nuclear / Q000096:biosynthesis*; D012333:RNA, Messenger; D051381:Rats
D003839:Deoxyadenosines; D012332:RNA, Heterogeneous Nuclear; D012333:RNA, Messenger; D011061:Poly A; D012313:RNA