Inflammatory particles stimulate thromboplastin production by human monocytes.
Several inflammatory particles (zymosan, two forms of asbestos, carrageenan) and the soluble inflammatory agent dextran sulphate induced a dose- and time-dependent increase in thromboplastin activity of cultured human monocytes. Two weakly inflammatory particles (latex and anatase) had little effect. The increase largely depended on protein synthesis; was slow, reaching a peak at about 18 h; and was not due to endotoxin. This procoagulant may contribute to the fibrin deposition frequently seen in inflammatory lesions.
D001194:Asbestos; D002351:Carrageenan; D002478:Cells, Cultured; D016264:Dextran Sulfate; D003911:Dextrans; D004731:Endotoxins; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D007840:Latex; D009000:Monocytes / Q000378:metabolism*; D011112:Polymyxin B / Q000494:pharmacology; D013925:Thromboplastin / Q000096:biosynthesis*; D015054:Zymosan
D003911:Dextrans; D004731:Endotoxins; D007840:Latex; D001194:Asbestos; D002351:Carrageenan; D015054:Zymosan; D013925:Thromboplastin; D016264:Dextran Sulfate; D011112:Polymyxin B