Effects of substance P-(1-9) nonapeptide amide on inactivation of substance P in vitro.
The effects of substance P nonapeptide amide on inactivation of substance P by the guinea-pig ileum and urinary bladder preparations and of substance P hexapeptide amide, bradykinin and acetylcholine by the guinea-pig urinary bladder, have been investigated. Significant inhibition of inactivation of Substance P was found only in the urinary bladder. None of the other agents were significantly affected. These results suggest that the previously reported agonist effects of substance P nonapeptide may be due to inhibition of inactivation of SP in vivo and this effect is possibly specific.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001920:Bradykinin / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000378:metabolism; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D010446:Peptide Fragments; D013373:Substance P / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D001743:Urinary Bladder / Q000378:metabolism
D010446:Peptide Fragments; D013373:Substance P; C035972:substance P (1-9); D000109:Acetylcholine; D001920:Bradykinin