Antigenic variation in Trypanosoma vivax: isolation of a serodeme.
Studies of antigenic variation in Trypanosoma vivax have been hindered by its low infectivity to laboratory hosts and difficulties in obtaining defined cloned populations. The recent isolation of mouse-infective T. vivax has partially overcome the first problem. We have developed a highly efficient cloning technique which has been applied to the isolation of a collection of 71 clones, representing 31 distinct variable antigen types, of mouse-infective T. vivax from Nigeria. This serodeme showed no cross-reaction with several T. brucei-group serodemes, but some cross-reaction with naturally occurring Kenyan T. vivax.
D000818:Animals; D002417:Cattle; D002999:Clone Cells; D000939:Epitopes / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D014644:Genetic Variation; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D012703:Serotyping; D014345:Trypanosoma / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D014353:Trypanosomiasis, African / Q000469:parasitology / Q000662:veterinary; D014354:Trypanosomiasis, Bovine / Q000469:parasitology
D000939:Epitopes