title: [Morphofunctional changes in the lymphoid tissue of the respiratory organs in gamma-globulin administration].
abstract: By means of macro-microscopic, histologic, radioautographic and immunomorphologic methods, three forms of the lymphoid tissue structural organization have been revealed in the rat respiratory organs: a lymphoid cluster, a lymphoid follicle and a lymphoepithelial nodule. After gamma-globulin is administered intranasally, the ratio of the lymphoid cells in the organs mentioned changes: the number of small lymphocytes decreases, while that of middle, large lymphocytes and blast cells increase. The lymphoid follicles consist of a central and a marginal zones, in the lymphoepithelial nodules the subepithelial and paranodular zones also exist. The gamma-globulin administration stimulates DNA synthesis by the cells of the lymphoid type and their proliferation; that results in increasing number of the antibody-synthesizing cells and is accompanied with an increasing titre of antibodies in washing from the bronchial tree. At a repeated stimulation, the processes are more intensive and develop more quickly.
mesh_terms: D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology; D004848:Epithelium / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000503:physiopathology; D009092:Mucous Membrane / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology; D013997:Time Factors; D014132:Trachea / Q000187:drug effects / Q000503:physiopathology; D005719:gamma-Globulins / Q000008:administration & dosage*
chemical_list: D005719:gamma-Globulins
vernacular_title: Morfofunktsioanl'nye izmeneniia limfoidnoĭ tkano organov dykhaniia pri vvedenii gamma-globulina.