Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting.
1. Measurements have been made of whole-body and skeletal muscle protein synthesis in fed and fasted adults with L-[1-13C]leucine. 2. The marked increase in whole-body synthesis on feeding largely reflects the changes in protein synthesis in muscle, which doubles on feeding, compared with a 40% increase in that of the rest of the body. 3. Skeletal muscle in fed man contributes more than half to total protein synthesis occurring in the whole body.
D000328:Adult; D002245:Carbon Dioxide / Q000097:blood; D002247:Carbon Isotopes; D004435:Eating; D005215:Fasting; D006801:Humans; D007651:Keto Acids / Q000097:blood; D007930:Leucine / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000096:biosynthesis*; D012313:RNA / Q000378:metabolism
D002247:Carbon Isotopes; D007651:Keto Acids; D009124:Muscle Proteins; D002245:Carbon Dioxide; D012313:RNA; C013082:alpha-ketoisocaproic acid; D007930:Leucine