Prevention by a carbacyclin analogue (ZK 36 374) of digoxin-induced ventricular extrasystoles in guinea-pig myocardium.
Intravenous infusion of ZK 36 374 to the anesthetized guinea-pig or addition of the compound to the perfusion medium of the isolated perfused guinea-pig heart prevented digoxin-induced ventricular premature beats without altering the prolongation of the P-R interval by the glycoside. The prevention by ZK 36 374 of the ventricular extrasystoles induced by digoxin was obtained at lower concentrations while higher doses of the compound produced a dysrhythmic effect which terminated within a few min after the cessation of drug application.
D000758:Anesthesia; D000818:Animals; D000889:Anti-Arrhythmia Agents; D005117:Cardiac Complexes, Premature / Q000139:chemically induced / Q000517:prevention & control*; D004077:Digoxin / Q000494:pharmacology*; D004562:Electrocardiography; D011464:Epoprostenol / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D016285:Iloprost; D066298:In Vitro Techniques
D000889:Anti-Arrhythmia Agents; D004077:Digoxin; D011464:Epoprostenol; D016285:Iloprost