Immunobiological properties of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79).
The immunological investigations were carried out on mice with the aim to determine the immunotropic properties of the complex of bivalent copper with 3-mercapto-2-hydroxypropyl ether of dextran (C-79), a derivative of previously described 3-morpholine-2-hydroxypropyl ether of dextran (H-2). In the examinations of the copper complex also the H-2 preparation was applied, and for comparative purposes--levamisol, a popular stimulator of immunological responses. It was stated that C-79 similarly to H-2 and levamisol, stimulated the humoral and cellular anti-SRBC immunological responses. Moreover, it increased the number of cells producing anti-H-B antibodies, stimulated the appearance of thy-1,2 antigen on the precursor T cells and inhibited the in vivo and in vitro GvH reactions. H-2 and C-79 preparations intensified the effect of the inductor of the Poli I:C.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000941:Antigens / Q000276:immunology; D003300:Copper / Q000276:immunology / Q000494:pharmacology*; D003911:Dextrans / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D000941:Antigens; D003911:Dextrans; D007978:Levamisole; C018905:dextran-2-hydroxy-3-mercaptopropyl ether; D003300:Copper; C041054:3-morpholine-2-hydroxypropyl dextran ether