Neuropeptide Y: regional distribution chromatographic characterization and immunohistochemical demonstration in post-mortem human brain.
Using a neuropeptide Y (NPY)-directed radioimmunoassay the post-mortem stability of NPY was assessed in both rat and human brain samples. The regional distribution of NPY-like immunoreactivity in human brain was determined. The NPY-like immunoreactivity in human brain separated on Sephadex G-50 columns and 18C reverse phase at the position expected for NPY. Immunohistochemical staining using the NPY-directed antiserum revealed a characteristic population of cortical and striatal neurons containing NPY-like immunoreactivity.
D000818:Animals; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009474:Neurons / Q000166:cytology; D009478:Neuropeptide Y; D011180:Postmortem Changes; D051381:Rats; D013194:Staining and Labeling; D014018:Tissue Distribution
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y