Diuretic-induced hypokalemia in uncomplicated systemic hypertension: effect of plasma potassium correction on cardiac arrhythmias.
Sixteen patients with diuretic-induced hypokalemia underwent 24-hour ambulatory electrocardiographic monitoring during and after correction of hypokalemia. Plasma potassium averaged 2.83 +/- 0.08 mEq/liter before and 3.73 +/- 0.06 mEq/liter after correction with potassium chloride, triamterene or both. Premature atrial contractions decreased in 6 patients, increased in 6 and remained unchanged in 4. There was no improvement in ventricular ectopic activity after plasma potassium correction. Ventricular ectopic activity improved in 5 patients, worsened in 10 and remained unchanged in 1. Ventricular tachycardia was not observed in either phase. Plasma magnesium remained normal throughout. The investigators conclude that in patients with uncomplicated hypertension, correction of diuretic-induced hypokalemia does not significantly reduce the occurrence of spontaneous atrial or ventricular ectopic activity.
D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D005117:Cardiac Complexes, Premature / Q000517:prevention & control; D002752:Chlorthalidone / Q000009:adverse effects; D004232:Diuretics / Q000009:adverse effects*; D004562:Electrocardiography; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects; D006973:Hypertension / Q000188:drug therapy*; D007008:Hypokalemia / Q000139:chemically induced* / Q000188:drug therapy; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011188:Potassium / Q000097:blood; D011189:Potassium Chloride / Q000627:therapeutic use; D014223:Triamterene / Q000627:therapeutic use
D000959:Antihypertensive Agents; D004232:Diuretics; D006852:Hydrochlorothiazide; D011189:Potassium Chloride; D002752:Chlorthalidone; D011188:Potassium; D014223:Triamterene