Epidermal lipids, barrier function, and desquamation.
Based on recent morphologic, histochemical, and biochemical data, we propose a heterogeneous two-compartment model of the stratum corneum that ascribes a special role for intercellular lipids in the regulation of stratum corneum barrier function and desquamation. The evidence in favor of the model and several predictions based on the model are surveyed in this review.
D002518:Ceramides / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007633:Keratins / Q000096:biosynthesis; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D011498:Protein Precursors / Q000096:biosynthesis; D012867:Skin / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D012871:Skin Diseases / Q000378:metabolism* / Q000473:pathology; D013194:Staining and Labeling; D013261:Sterols / Q000032:analysis; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000378:metabolism
D002518:Ceramides; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D011498:Protein Precursors; D013261:Sterols; C001500:keratohyalin; C032253:involucrin; D007633:Keratins; D013429:Sulfatases; D043266:Steryl-Sulfatase