The augmentation of human NK-cell activity by auranofin compared to interferon.
The cytotoxic activity of natural killer cells is markedly increased by interferon (IFN) and IFN inducers. Auranofin, an oral gold preparation, has an effect similar in size and rapidity to that of IFN but, in contrast, the Auranofin effect does not require RNA synthesis by the effector cells.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D002051:Burkitt Lymphoma; D002460:Cell Line; D002860:Chromium Radioisotopes; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D006046:Gold / Q000031:analogs & derivatives*; D006801:Humans; D066298:In Vitro Techniques; D007372:Interferons / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects*; D004915:Leukemia, Erythroblastic, Acute; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000276:immunology; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis
D002860:Chromium Radioisotopes; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D003609:Dactinomycin; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold; D007372:Interferons; D003513:Cycloheximide