Xanthogranuloma juvenile: a case report.
A case of juvenile xanthogranuloma in a female newborn infant is reported. Red-brown, flat, well-demarcated lesions were present at birth on her scalp, face and trunk. During the following year of observation the eruptions regressed slowly and spontaneously. Light and electron microscopy revealed histiocytes and Touton giant cells dominating the dermal cell infiltrate. The Touton cells contained bizarre invaginated nuclei, lysosomes, a granular endoplasmic reticulum, and cholesterol clefts in their cytoplasm. No fat droplets were seen.
D005260:Female; D006644:Histiocytes / Q000648:ultrastructure; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology*; D008854:Microscopy, Electron; D012867:Skin / Q000166:cytology; D014972:Xanthogranuloma, Juvenile / Q000473:pathology*