title: The mode of action of berninamycin and mechanism of resistance in the producing organism, Streptomyces bernensis.
abstract: The mode of action of berninamycin on bacterial protein synthesis is related to that of thiostrepton, a dissimilar compound. Both antibiotics bind to the complex of 23S RNA with protein L11 and both affect various functions of the ribosomal A site. Also, Streptomyces bernensis and Streptomyces azureus (which, respectively, produce berninamycin and thiostrepton) possess similar ribosomal RNA methylases capable of rendering ribosomes resistant to these compounds. Resistance involves specific pentose-methylation of 23S ribosomal RNA.
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D004352:Drug Resistance, Microbial; D006160:Guanosine Triphosphate / Q000096:biosynthesis; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism; D010455:Peptides; D010456:Peptides, Cyclic / Q000096:biosynthesis; D012329:RNA, Bacterial / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism*; D013883:Thiostrepton / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D010456:Peptides, Cyclic; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D006160:Guanosine Triphosphate; D012343:RNA, Transfer; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; D013883:Thiostrepton; C011405:berninamycin A