[The effect of anti-human AFP serum for AFP producing stomach cancer xenotransplanted nude mice].
The effect of anti-human alpha-fetoprotein (AFP) on growth, serum AFP levels and histological changes of two lines of AFP producing stomach cancer serially xenotransplanted in nude mice were examined. The efficacy of anti-human AFP antibody on tumor growth was observed specifically for the tumor producing AFP, but there was great difference on growth between two lines. The AFP levels of the serum disclosed a rapid decrease after administration of antibody and maintained as level of Ong/ml for a long period. On histopathologic examination, there were not observed any changes on the tumor cells and structure and necrotic change was not demonstrated. By the immunohistochemical examination (PAP method), anti-human AFP antibody was identified in tumor even 50 th days later after injection.
D000230:Adenocarcinoma / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D000231:Adenocarcinoma, Papillary / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D000293:Adolescent; D000368:Aged; D000818:Animals; D000912:Antibodies, Neoplasm / Q000627:therapeutic use*; D004285:Dogs; D006801:Humans; D007116:Immunization, Passive; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D014183:Transplantation, Heterologous; D000509:alpha-Fetoproteins / Q000276:immunology* / Q000378:metabolism
D000912:Antibodies, Neoplasm; D000509:alpha-Fetoproteins