REM sleep eye movement activity and CSF concentrations of 5-hydroxyindoleacetic acid in psychiatric patients.
The relationship between rapid-eye-movement (REM) sleep tonic and phasic activity measures and the pre- and postprobenecid cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) was examined in a sample of 14 unmedicated psychiatric patients. The average duration of an eye movement burst and the average number of eye movements within a burst were found to be inversely related to the probenecid corrected accumulation of 5-HIAA in the CSF. These results are interpreted as indicating an association between REM burst eye movement activity and serotonin turnover in psychiatric subjects.
D000328:Adult; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011339:Probenecid; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D012895:Sleep, REM / Q000502:physiology*
D006897:Hydroxyindoleacetic Acid; D011339:Probenecid