title: [Silver staining of the nucleolus organizer regions in the interphase cells of an embryonic pig kidney culture during and after administration actinomycin D].
abstract: Silver staining of nucleolus organizer regions was used for studying their structural alterations during inhibition of ribosomal RNA synthesis by actinomycin D and after its removal in pig kidney cells. Three nuclear types were revealed from the pattern of restored silver grains distribution in the nuclei. When the inhibitor was removed, nuclear multitype gradually disappeared for 24 hours and nuclear RNA synthesis became normal.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003609:Dactinomycin / Q000494:pharmacology*; D007399:Interphase / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000196:embryology / Q000648:ultrastructure; D009697:Nucleolus Organizer Region / Q000187:drug effects / Q000648:ultrastructure*; D013194:Staining and Labeling / Q000379:methods; D013997:Time Factors
chemical_list: D003609:Dactinomycin
vernacular_title: Serebrenie raĭonov iadryshkovykh organizatorov v interfaznykh kletkakh kul'tury SPEV pri deĭstvii i posle sniatiia deĭstviia aktinomitsina D.