[Immunopharmacological actions of 6-amidino-2-naphthyl-4-guanidinobenzoate (FUT-175). 2. Effect of FUT-175 on immunological reactions in man].
FUT-175 is a new anti-complemental drug which strongly inhibits complement-mediated allergic reactions in animals. It was reported that FUT-175 does not affect both antibody formation and host defense to bacterial infection in mice. The present study was undertaken to examine the effects of FUT-175 on various immunological reactions in humans. FUT-175 dose-dependently decreased the antigen-induced anaphylactic histamine release from leukocytes of atopic patients. However, i.d. treatment of FUT-175 neither inhibited antigen- or compound 48/80-induced immediate type skin reactions in atopic patients nor antigen-induced early, late or delayed type skin reactions in Candida-sensitive patients. FUT-175 also did not inhibit the PPD-mediated delayed type skin reaction in healthy subjects. FUT-175 at a dose of 10(-4)M but not at 10(-8) to 10(-5)M significantly decreased the proliferation of human atopic peripheral blood lymphocytes (PBL) caused by mite antigen, concanavalin A or pokeweed mitogen. 51Cr release from human PBL was slightly enhanced by FUT-175 at a dose range of 10(-6) to 10(-4)M. FUT-175 did not change the number of SIg receptors or C3 receptors on human B cells. FUT-175 hardly affected the nitroblue tetrazolium reduction test and Escherichia coli-mediated chemotaxis in human neutrophils. These results strongly suggest that FUT-175 does not affect immunological functions and host defense in humans.
D001550:Benzamidines; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006146:Guanidines / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007428:Intradermal Tests; D008213:Lymphocyte Activation / Q000187:drug effects; D011480:Protease Inhibitors / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000032:analysis
D001550:Benzamidines; D006146:Guanidines; D011480:Protease Inhibitors; D011971:Receptors, Immunologic; C032855:nafamostat