Pluripotential nature of mesotheliomata induced by inhalation of erionite in rats.
Mesotheliomata can be induced more rapidly and more frequently by inhalation of erionite than by asbestos inhalation. Erionite-induced tumours have in general a similar ultrastructural appearance to inoculum-induced pleural and peritoneal mesotheliomata. Unusual features of these tumours were the presence of dense-cored vesicles and cells staining positively for neuron-specific enolase which indicated the presence of endocrine cells. In addition, one tumour showed differentiation towards bone-forming cells. The expression of both epithelial and mesodermal characteristics demonstrates the pluripotential nature of mesothelial cells under certain circumstances.
D000538:Aluminum Silicates / Q000633:toxicity*; D000818:Animals; D007633:Keratins / Q000032:analysis; D008654:Mesothelioma / Q000032:analysis / Q000209:etiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D010997:Pleural Neoplasms / Q000032:analysis / Q000209:etiology* / Q000648:ultrastructure; D051381:Rats; D017641:Zeolites
D000538:Aluminum Silicates; D017641:Zeolites; D007633:Keratins; D010751:Phosphopyruvate Hydratase