title: Effects of low levels of dietary lead and iron on hepatic RNA, protein, and minerals in young Japanese quail.
abstract: Day-old Japanese quail were fed purified diets containing either 0.2 (control), 5.4, or 16.2 ppm lead as the acetate with either 25 (deficient) or 100 ppm (adequate control) iron for 2 weeks. Iron deficiency caused decreases in hemoglobin, iron, and manganese in the liver, and hepatic RNA synthesis. Iron deficiency also caused increased concentrations of lead, calcium, and molybdenum in the liver. Lead supplements caused increased concentrations of lead in the liver, and with adequate dietary iron, each supplemental lead level caused a slight decrease in the concentration of RNA in the liver. Treatment had no effect on DNA or protein synthesis, body weight, or liver weight in relation to body weight. These low levels of dietary lead did not cause the same adverse metabolic effects observed by others with higher levels of lead; however, iron deficiency increased lead uptake by the liver and affected RNA synthesis.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003370:Coturnix; D004247:DNA / Q000096:biosynthesis*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000494:pharmacology; D000090463:Iron Deficiencies; D007854:Lead / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009942:Organometallic Compounds; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D014131:Trace Elements / Q000032:analysis*
chemical_list: D006454:Hemoglobins; D009942:Organometallic Compounds; D014131:Trace Elements; D007854:Lead; D012313:RNA; D004247:DNA; D007501:Iron; C008261:lead acetate