Isoproterenol induced changes in myocardial nucleic acids.
Daily subcutaneous injections of isoproterenol increased heart weight 42% after 4 days of therapy. Ventricular RNA concentration was significantly elevated after 24 hours. Myocardial DNA was initially unchanged but significantly increased after 8 days of treatment. Ventricular systolic, diastolic pressures and coronary flow were not diminished in hypertrophied hearts. However, muscle contractility was slightly increased (P less than .05).
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D009696:Nucleic Acids / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009696:Nucleic Acids; D012313:RNA; D004247:DNA; D007545:Isoproterenol