Hydrogels by irradiation of a synthetic heparinoid polyelectrolyte.
Gamma irradiation of aqueous solutions of a synthetic heparinoid polyelectrolyte results in the formation of hydrogels, varying in water content and mechanical strength. The equilibrium water content and the mechanical strength of the hydrogels are dependent on the initial polyelectrolyte concentration, the molecular weight of the polyelectrolyte, the percentage of double bonds in the polyelectrolyte and the radiation dose. The polyelectrolyte hydrogels do not deplete Antithrombin III from blood and there is no activation of factor XII according to an in vitro kallikrein generation test. However, in a very sensitive test for factor XII activation (contact promoted shortening of the thrombotest) a slight activation of this factor was observed.
D001672:Biocompatible Materials; D005174:Factor XII / Q000378:metabolism; D006493:Heparin; D006496:Heparinoids / Q000528:radiation effects*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007610:Kallikreins / Q000378:metabolism; D011092:Polyethylene Glycols / Q000494:pharmacology; D011108:Polymers / Q000528:radiation effects*
D001672:Biocompatible Materials; D006496:Heparinoids; D011108:Polymers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D005174:Factor XII; D006493:Heparin; D007610:Kallikreins