title: Phosphorylcholine determinants in six pneumococcal capsular polysaccharides detected by monoclonal antibody.
abstract: The presence of phosphorylcholine in pneumococcal capsular polysaccharides was examined by using monoclonal antiphosphorylcholine antibody. Of the 83 known capsular types of Streptococcus pneumoniae, 6 types, viz., 24A, 27, 28F, 28A, 32F, and 32A, gave a positive capsular reaction (quellung) which could be inhibited by phosphorylcholine. The capsular polysaccharides of these six types, therefore, contain phosphorylcholine.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D002794:Choline / Q000031:analogs & derivatives*; D000939:Epitopes / Q000276:immunology; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010767:Phosphorylcholine / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000939:Epitopes; D011135:Polysaccharides, Bacterial; C027158:polysaccharide C-substance (Streptococcus); D010767:Phosphorylcholine; D002794:Choline