1,10-Phenanthroline reversibility inhibits proliferation of two human prostate carcinoma cell lines (PC-3 and DU145).
The metal chelator 1,10-phenanthroline reversibly inhibits proliferation of two human prostate carcinoma cell lines, PC-3 and DU145. Inhibition is dose-dependent, and persists for several days after removal of the chelator. The ability to induce reversible quiescence in human prostate carcinoma cells in vitro may facilitate the study of their growth cycle biochemistry.
D000954:Antigens, Surface / Q000032:analysis; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007700:Kinetics; D008297:Male; D010618:Phenanthrolines / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D013936:Thymidine / Q000378:metabolism
D000954:Antigens, Surface; D000939:Epitopes; D010618:Phenanthrolines; D013936:Thymidine; C025205:1,10-phenanthroline