[Macrophage adherence inhibition test (MAI) in Wistar rats bearing Jensen tumors. I. MAI after incubation with tumor-associated antigens].
In the present report investigations for cellular sensitization against Jensen-sarcoma of the white rat are performed. Macrophage-Adherence-Inhibition-Test according to Halliday and Miller in a modification according to Schimke was the applied test. A significant adherence-inhibition of peritoneal cells of tumor-bearing rats was found in comparison to control animals with a plateau on day 12 after transplantation and a praemortal eclipse phenomenon from day 19 after inoculation with tumor cells. The concentration of immune complexes shows the same manner, but was especially high in animals with small or not-taken tumors, whereas MAI-index was similar to that of the control group. Antibody production against the tumor could not be detected with Ouchterlony-precipitation. Non-specific immunotherapy with DNCB and BCG as well as therapy with soluble tumorantigen in KFA and insoluble polymerized extracts in 2 TU PPD were unsuccessful to prevent the development of tumors in the model.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002448:Cell Adhesion; D005260:Female; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012509:Sarcoma / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology
D000951:Antigens, Neoplasm; D004676:Myelin Basic Protein
Der Makrophagen-Adhärenz-Hemmtest (MAI) bei Jensen-Tumor-tragenden Wistar-Ratten. I. MAI nach Inkubation mit tumorassoziierten Antigenen.