Sex steroid hormones levels and testicular activity during hepatocarcinogenesis by N-2-fluorenylacetamide.
During hepatocarcinogenesis by N-2-fluorenylacetamide, the hormonal status of male Sprague-Dawley rats is modified. The testes present a reduced activity which is evidenced by a decreased spermatogenetic activity accompanied by a drastic decrease of the plasma testosterone level. In contrast, plasma progesterone and estradiol-17 beta levels were not modified despite the 80 fold augmentation of alpha-fetoprotein, an estrogen binding protein synthesized during liver carcinogenesis.
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000818:Animals; D004958:Estradiol / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D011374:Progesterone / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000097:blood
D012739:Gonadal Steroid Hormones; D000509:alpha-Fetoproteins; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D015073:2-Acetylaminofluorene