title: Investigation of the idiotypic determinants of IgM monoclonal proteins associated with neuropathy.
abstract: Occasionally IgM monoclonal proteins (MP) from benign gammopathies bind neural antigens and have been associated with demyelinating peripheral neuropathy. A monoclonal antibody (McAb) has been raised against a cross-reactive idiotypic determinant expressed by three out of 12 MP with specificity for neural antigens. The determinant recognised by this MoAb is only expressed when both H and L chain are properly associated. The idiotypic determinant was not expressed by 130 MP randomly selected from patients without neuropathy nor in polyclonal immunoglobulin preparations obtained from healthy individuals.
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D006386:Hemagglutination Tests; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M