title: Collagenase and elastase in the serum of adjuvant arthritic rats.
abstract: Collagenase and elastase activities in the serum of adjuvant arthritic rats declined with time as the disease progressed and did not parallel increases in alpha 1-macroglobulin or alpha 2-acute phase globulin levels. The fall in collagenase and elastase activities was accompanied by a decline in serum alpha 1-proteinase inhibitor levels. It was concluded that the fall in collagenase and elastase activities in serum was due to inactivation by serum anti-proteases.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000201:enzymology*; D001169:Arthritis, Experimental / Q000201:enzymology* / Q000473:pathology; D010450:Endopeptidases / Q000097:blood; D008297:Male; D003012:Microbial Collagenase / Q000097:blood*; D010196:Pancreatic Elastase / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012697:Serine Endopeptidases; D014361:Trypsin Inhibitors / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D014361:Trypsin Inhibitors; D000511:alpha-Macroglobulins; D010450:Endopeptidases; D012697:Serine Endopeptidases; D010196:Pancreatic Elastase; D003012:Microbial Collagenase