title: Frequent ventricular ectopic activity without underlying cardiac disease: analysis of 45 subjects.
abstract: Forty-five subjects, aged 2 weeks to 62 years, who presented with frequent (greater than 100/day) ventricular ectopic beats (VEBs) and without evidence of underlying cardiac disease were studied. The spectrum of ventricular dysrhythmia was assessed by 24-hour ambulatory electrocardiography and exercise tolerance test. Sinus rhythm was the prevailing rhythm in all subjects. VEB frequency averaged 444 +/- 454 per hour (range 0 to 1,863) over the 24-hour monitoring period and was not significantly different during waking or sleeping periods. There was no simple correlation of VEB frequency with prevailing sinus rate (r = -0.0006; p = not significant [NS]). The prevalence of complex VEBs (multiform, R-on-T and repetitive) was relatively high (18 of 45 patients), and was equally distributed about the median VEB frequency of 314 VEBs/hour (7 of 18 versus 11 of 18; NS). Of the 43 subjects who had exercise tests, 37 had VEBs during the preexercise rest phase, compared with only 11 at peak exercise (p less than 0.0001). To assess the short-term natural history of the VEBs, 27 subjects had repeat clinical examinations and 24-hour electrocardiograms at a mean interval of 8 months. All remained well. Although there was considerable individual temporal variability of VEB frequency in this subgroup, there was no significant change in group mean values (415 +/- 409 VEBs/hour initially versus 401 +/- 383 VEBs/hour at follow-up study; NS). The relative temporal constancy of VEB frequency in the group as a whole was also reflected in a high linear correlation of VEB frequency at initial and follow-up studies (r = 0.816; p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000293:Adolescent; D000328:Adult; D005117:Cardiac Complexes, Premature / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis*; D006339:Heart Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D005082:Physical Exertion; D012306:Risk