[Pharmacokinetics of the antitumor antibiotic bleomycetin in cancer patients given the preparation by different methods].
The pharmacokinetics of bleomycetin, a new antitumor antibiotic prepared in the USSR, was studied microbiologically. The less the extent of the main tumor in the patients, the higher the antibiotic blood levels in them. This might be associated with the adsorption capacity of the tumor tissue. The dependence of the bleomycetin kinetics on the intensity of renal clearance was shown. The characteristics of the drug distribution in the blood after intravenous, intramuscular and intrapleural administration are presented.
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000378:metabolism*; D001412:Bacillus subtilis / Q000187:drug effects; D001761:Bleomycin / Q000008:administration & dosage / Q000378:metabolism* / Q000031:analogs & derivatives; D006801:Humans; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; C025703:bleomycetin
Farmakokinetika protivoopukholevogo antibiotika bleomitsetina u onkologicheskikh bol'nykh pri razlichnykh metodakh vvedeniia preparata.