Translation in vitro of RNA from the human malarial parasite Plasmodium falciparum.
RNA has been isolated from the human malarial parasite, Plasmodium falciparum, and translated in vitro using two systems: rabbit-reticulocyte lysate and Xenopus laevis oocytes. Polypeptides are synthesized that are characteristic of the parasite isolate and the developmental stage from which the RNA was purified. Many of these polypeptides are precipitated by antibody from an immune monkey. Analysis of the primary structure of these polypeptides should give the information necessary to produce a vaccine against this parasite.
D000818:Animals; D005260:Female; D006801:Humans; D008970:Molecular Weight; D009865:Oocytes / Q000378:metabolism; D010455:Peptides / Q000302:isolation & purification; D010963:Plasmodium falciparum / Q000378:metabolism*; D014176:Protein Biosynthesis; D012313:RNA / Q000235:genetics*; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D014981:Xenopus
D010455:Peptides; D012313:RNA