Reconstitution of primary, severe, combined immunodeficiency in man and horse.
Severe combined immunodeficiency disease (SCID) in foals is the only known animal model for the autosomal recessive form of primary SCID in man. A major requirement in the treatment of SCID is the maintenance of the patient in a disease free state until definitive therapy can be undertaken. This paper reviews the current status of prophylactic and definitive therapy in man and the horse. Particular emphasis is placed on the methods of reconstitution available, involving foetal tissues and bone marrow.
D000243:Adenosine Deaminase / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001803:Blood Transfusion; D016026:Bone Marrow Transplantation; D005333:Fetus; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy* / Q000662:veterinary; D016031:Liver Transplantation; D013950:Thymus Gland / Q000637:transplantation; D013951:Thymus Hormones / Q000627:therapeutic use; D014165:Transfer Factor / Q000627:therapeutic use; D005719:gamma-Globulins / Q000627:therapeutic use
D000890:Anti-Infective Agents; D013951:Thymus Hormones; D014165:Transfer Factor; D005719:gamma-Globulins; D000243:Adenosine Deaminase