Histamine release into tracheal lumen and bronchial reactivity. Effect of local histamine administration on histamine release and bronchial reactivity.
The influence of tracheal lavage with histamine, and of i.v. administration of histamine on bronchospastic response was studied in 16 dogs. Airway response to acetylcholine inhalation was significantly increased after tracheal lavage with high concentrated histamine solution (1%). No influence on airway response was found after (1) tracheal lavage with lower concentrations of histamine and (2) its i.v. administration. The clinical importance of these manifestations is discussed.
D000109:Acetylcholine / Q000494:pharmacology; D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine / Q000097:blood / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D007507:Therapeutic Irrigation; D014132:Trachea / Q000187:drug effects
D006632:Histamine; D000109:Acetylcholine