title: The nerves to blood vessels supplying blood to nerves: the innervation of vasa nervorum.
abstract: Noradrenergic, serotoninergic and peptidergic nerves have been demonstrated in perivascular plexuses of vasa nervorum of sympathetic, parasympathetic and somatic nerve trunks. 5-Hydroxytryptamine-, vasoactive intestinal polypeptide- and substance P-containing fibers were found by immunohistochemistry to variable extents in whole mounts of the epineurium of sciatic, vagus and paravertebral sympathetic chains of rabbits. Innervation increased with age. This suggests an hitherto unsuspected role for these vasoactive substances in normal blood flow to nerves and in the genesis of experimental and human neuropathies.
mesh_terms: D000367:Age Factors; D000818:Animals; D001808:Blood Vessels / Q000294:innervation*; D005455:Fluorescent Antibody Technique; D005728:Ganglia, Sympathetic / Q000098:blood supply*; D009411:Nerve Endings / Q000378:metabolism; D011817:Rabbits; D012584:Sciatic Nerve / Q000098:blood supply*; D012701:Serotonin / Q000378:metabolism; D013373:Substance P / Q000378:metabolism; D014630:Vagus Nerve / Q000098:blood supply*; D014650:Vasa Nervorum / Q000294:innervation*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D012701:Serotonin; D013373:Substance P; D014660:Vasoactive Intestinal Peptide