title: [Anaphylactic reactions in mediastinal echinococcosis].
abstract: A boy with inoperable mediastinal echinococcosis is reported, who developed anaphylactic reactions during chemotherapy with mebendazole. IgE-mediated hypersensitivity was demonstrated by elevated echinococcus-specific serum IgE-antibody concentrations, by allergen-induced histamine release from washed leukocytes, and by passive sensitization of nonsensitized leukocytes with the patient's serum. During hyposensitization with echinococcus antigen no further anaphylactic symptoms were observed over a two years period. There was a decrease in allergen-specific serum IgE-concentrations and in basophil sensitivity to echinococcus antigen. The indication for hyposensitization in echinococcosis is discussed.
mesh_terms: D000293:Adolescent; D000707:Anaphylaxis / Q000276:immunology*; D000941:Antigens / Q000008:administration & dosage; D003888:Desensitization, Immunologic; D004443:Echinococcosis / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy; D004446:Echinococcus / Q000276:immunology; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage; D008477:Mediastinal Diseases / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy
chemical_list: D000941:Antigens; D007073:Immunoglobulin E; D008463:Mebendazole
vernacular_title: Anaphylaktische Reaktionen bei mediastinaler Echinokokkose.