Functional properties of antigen-specific T cells infected by human T-cell leukemia-lymphoma virus (HTLV-I).
Tetanus-toxoid specific helper-inducer T-cell clones, which had been infected and transformed by human T-cell leukemia-lymphoma virus (HTLV-I), were obtained from an antigen-specific human T cell line by using a limiting dilution technique in the presence of the virus. These HTLV-I-infected T-cell clones proliferated specifically in response to soluble tetanus toxoid but, unlike normal T cells, they could do so in the absence of accessory cells. The HTLV-I-infected T-cell clones did not present the antigen to autologous antigen-specific T cells that were not infected with HTLV-I. The capacity of helper-inducer T cells to retain antigen-specific reactivity after infection by HTLV-I, while losing the normal T-cell requirement for accessory cells, has clinical and theoretical implications.
D000954:Antigens, Surface / Q000032:analysis; D001665:Binding Sites; D002460:Cell Line; D002472:Cell Transformation, Viral; D017977:Deltaretrovirus / Q000235:genetics / Q000502:physiology*; D000939:Epitopes / Q000378:metabolism; D005814:Genes, Viral; D006801:Humans; D008213:Lymphocyte Activation; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology; D013745:Tetanus Toxoid / Q000276:immunology; D014764:Viral Proteins / Q000096:biosynthesis
D000954:Antigens, Surface; D000939:Epitopes; D013745:Tetanus Toxoid; D014764:Viral Proteins