title: The effects of a single dose and prolonged benzene administration on 5-hydroxytryptamine and 5-hydroxyindolacetic acid content in rat brain.
abstract: The contents of serotonin (5-HT) and its major metabolite, 5-hydroxyindolacetic acid (5-HIAA), in the hypothalamus, the striatum and the remainder of the brain, after a single dose and prolonged administration of benzene were studied in rats. Benzene was injected s.c. in doses of 1/20-1/5 LD50 for single administration and in doses of 1/80-1/20 LD50 daily six days a week during four weeks of prolonged administration. Single administration produced a decrease in the 5-HT content of the hypothalamus and striatum, accompanied by an increase of the 5-HIAA level in the striatum. The highest contents of both 5-HT and 5-HIAA in the hypothalamus and the striatum were seen 45 min after benzene injection and lasted for at least 180 min. After prolonged benzene administration increases of both 5-HT and 5-HIAA contents were observed, particularly with striatum. The accelerated 5-HT turnover in rat brain after acute and prolonged administration of benzene indicates an effect of the hydrocarbon on the metabolism of 5-HT.
mesh_terms: D000818:Animals; D001554:Benzene / Q000008:administration & dosage / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D001554:Benzene