Histamine release from rat mast cells induced by the lectin from the snail, Cepaea nemoralis L. - a counterpart to the triggering action of polycations?
One of the two lectins, occurring in the albumen gland of the snail, Cepaea nemoralis L., is shown to be a histamine releaser from isolated rat mast cells as well as in vivo. The release reaction is induced in the same dosage range as the agglutination of human red blood cells occurs. Both the reactions are inhibitable by the addition of N-acetyl-neuraminic acid. The releasing activity of the lectin seems to be a counterpart to the triggering action of polycations, because its specificity is directed against this sugar.
D000116:Acetylgalactosamine / Q000378:metabolism; D000818:Animals; D002412:Cations; D005260:Female; D006636:Histamine Release; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D046911:Macromolecular Substances; D008407:Mast Cells / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012908:Snails / Q000032:analysis*
D002412:Cations; D037102:Lectins; D046911:Macromolecular Substances; D000116:Acetylgalactosamine