title: Substance P in the rat parotid gland: evidence for a dual origin from the otic and trigeminal ganglia.
abstract: The substance P innervation of the rat parotid was investigated using retrograde tracing with the fluorescent dye True Blue, in combination with the immunohistochemical localization of substance P. Retrogradely-labelled cells were seen in the otic, trigeminal, superior cervical and nodose ganglia. A proportion of the True Blue-labelled cells in the otic and trigeminal ganglia also contained substance P-like immunoreactivity providing direct evidence for a dual origin of substance P in the rat parotid. In addition, these results imply that in the rat otic ganglion substance P and acetylcholine coexist.
mesh_terms: D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000378:metabolism; D005260:Female; D005726:Ganglia, Parasympathetic / Q000378:metabolism; D008297:Male; D009620:Nodose Ganglion / Q000378:metabolism; D010275:Parasympathetic Nervous System / Q000378:metabolism; D010306:Parotid Gland / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000378:metabolism*; D014276:Trigeminal Nerve / Q000378:metabolism*
chemical_list: D013373:Substance P