Inflammation, counter irritation and rat serum acute phase alpha 2-macroglobulin levels.
Following the injection of turpentine and carrageenan into rats, laboratory models for counter irritation were assessed by measuring changes in paw thicknesses and serum acute phase alpha 2-macroglobulin concentrations. Both indices of inflammation were also examined in groups of rats dosed with 6-mercaptopurine, the best inhibitor found so far of elevated levels of alpha 2-macroglobulin in rat serum. Results showed that there is no relationship between the degree of irritant-induced inhibition of inflammation and the serum concentration of the acute phase protein. Hence, at least in the models for counter irritation used in this study, alpha 2-macroglobulin cannot be viewed as an endogenous anti-inflammatory protein.
D000818:Animals; D001169:Arthritis, Experimental / Q000097:blood; D002351:Carrageenan / Q000494:pharmacology; D007249:Inflammation / Q000097:blood*; D007509:Irritants / Q000494:pharmacology*; D008297:Male; D015122:Mercaptopurine / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014425:Turpentine / Q000494:pharmacology; D000511:alpha-Macroglobulins / Q000378:metabolism*
D007509:Irritants; D000511:alpha-Macroglobulins; D002351:Carrageenan; D015122:Mercaptopurine; D014425:Turpentine