Regional distribution of substance P-like immunoreactivity in the lower brainstem of the rat.
A radioimmunoassay was used to quantify substance P-like immunoreactivity in the lower brainstem of the rat. The peptide was detectable in all brainstem nuclei investigated. A very high concentration was found in the substantia nigra, and high concentrations in the interpeduncular nucleus and central gray matter. Levels in the pons, the parabrachial nuclei; in the medulla, the nucleus tractus spinalis of the Vth nerve and the nucleus of the solitary tract were higher than the brain average.
D000818:Animals; D001931:Brain Mapping; D001933:Brain Stem / Q000378:metabolism*; D005260:Female; D009115:Muridae; D009412:Nerve Fibers / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009619:Nociceptors / Q000378:metabolism; D011311:Pressoreceptors / Q000378:metabolism; D011863:Radioimmunoassay; D013373:Substance P / Q000378:metabolism*; D009435:Synaptic Transmission
D013373:Substance P