[Theoretical conformation analysis of specific O-antigenic polysaccharides. Polysaccharide of Shigella dysenteriae of serotype 2].
Theoretical conformational analysis of Shigella dysenteriae serotype 2 polysaccharide containing repeating unit: -4Gal beta 1-3GalNAc alpha 1-3(GlcNAc alpha 1-4)GalNAc alpha 1-4Glc alpha 1- has been carried out. It is shown that spatial forms of the polymer are determined by conformational states of Glc alpha 1-4Gal links which form the internal bends of the chain. The structures of low energy are shown to be left three-fold helices with an axially projected repeat of approximately 12 A. N-Acetamide groups of side residues alpha-D-GlcNAc are the most accessible for intermolecular interactions and may determine immunological specificity of the polysaccharide.
D000942:Antigens, Bacterial / Q000032:analysis*; D008958:Models, Molecular; D019081:O Antigens; D011135:Polysaccharides, Bacterial / Q000032:analysis*; D011487:Protein Conformation; D012703:Serotyping; D012762:Shigella dysenteriae / Q000145:classification / Q000276:immunology*
D000942:Antigens, Bacterial; D019081:O Antigens; D011135:Polysaccharides, Bacterial
Teoreticheskiĭ konformatsionnyĭ analiz spetsificheskikh O-antigennykh polisakharidov. Polisakharid Shigella dysenteriae serotipa 2.