Prognostic value of beta-thromboglobulin in patients with transient cerebral ischaemia.
Plasma levels of beta-thromboglobulin (BTG) and fibrinopeptide A (FPA), markers of platelet alpha-granule release and thrombin generation respectively, were measured in 27 subjects with transient cerebral ischaemic attacks (TIA), 43 age-matched controls, and 32 young controls. BTG and FPA were both higher in elderly controls than in young controls. BTG was higher in TIA subjects than in age-matched controls and higher in the 12 TIA subjects who had further vascular events in the next year than in those who had no further events. FPA was not significantly associated with TIA or with further events. These results support a relationship between platelet activation and TIA and suggest that BTG levels indicate a group at higher risk of further vascular events.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001241:Aspirin / Q000494:pharmacology; D001609:Beta-Globulins / Q000032:analysis*; D001792:Blood Platelets / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D004176:Dipyridamole / Q000494:pharmacology; D005260:Female; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012306:Risk; D013997:Time Factors; D001620:beta-Thromboglobulin / Q000032:analysis*
D001609:Beta-Globulins; D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; D004176:Dipyridamole; D001241:Aspirin