[Effect of thrombopenia on bone marrow CFU-S level and its capability to modify the circulating thrombocyte number].
Thrombocytopenia (rise of the thrombopoietin level) was induced by an antithrombocyte serum in mice. After 6 hours of existence of thrombocytopenia, the CFU-S and megakaryocyte-commmitted stem cell content of the bone marrow and spleen was determined by transplantation into mice pretreated with 800 cGy-rtg irradiation. Thrombocytopenia did not influence the CFU-S content. Thrombocytopoiesis of the recipient mice was better restored by bone marrow and spleen cells of thrombocytopenic animals than by cells transplanted from animals with a normal thrombocyte count.
D000818:Animals; D001792:Blood Platelets / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D006023:Glycoproteins / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D008533:Megakaryocytes / Q000473:pathology; D051379:Mice; D010976:Platelet Count; D013154:Spleen / Q000473:pathology* / Q000637:transplantation; D013921:Thrombocytopenia / Q000097:blood*; D013926:Thrombopoietin / Q000378:metabolism / Q000502:physiology*
D006023:Glycoproteins; D013926:Thrombopoietin
Die Auswirkung der Thrombopenie auf den CFU-S-Gehalt des Knochenmarks und seine Fähigkeit zur Beeinflussung der zirkulierenden Thrombozytenzahl.