title: Hormonal and renal response to plasma volume expansion in the primate Macaca mulatta.
abstract: The purpose of this study was to investigate the hormonal and renal response to plasma volume expansion in the ketamine-anesthetized rhesus monkey. The blood volume was determined in nine animals and found to be 6% of the body weight. Six monkeys received isoncotic isotonic fluid amounting to 25% of the blood volume. Plasma volume expansion led to significant decrease in the plasma concentrations of antidiuretic hormone (46.7%) and aldosterone (78.4%) as well as plasma renin activity (50.0%). The mean arterial pressure, plasma osmolality, and plasma concentrations of Na+ and K+ were unaffected by plasma volume expansion. However, renal plasma flow, glomerular filtration rate, the excretion of Na+ and K+, and urine flow increased. It was concluded that, in the ketamine-anesthetized rhesus monkey, circulating hormones contribute to blood volume homeostasis presumably through a neural mechanism similar to that observed in dogs and humans.
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology*; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000098:blood supply* / Q000502:physiology; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D010952:Plasma Substitutes; D010953:Plasma Volume / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014667:Vasopressins / Q000097:blood*
chemical_list: D003911:Dextrans; D010952:Plasma Substitutes; D014667:Vasopressins; D000450:Aldosterone; D012964:Sodium; D011188:Potassium