The behavioural effects of intrathecally administered [D-PRO2, D-TRP7,9]-substance P, an analogue with presumed antagonist actions, in the rat.
[D-Pro2, D-Trp7,9]-substance P, an analogue of the putative nociceptive primary afferent neurotransmitter substance P, was administered to rats via chronically implanted intrathecal catheters (0.5-2.5 nmol per rat). Several animals showed large elevations of thermal and mechanical nociceptive thresholds, but these effects were always accompanied by profound, often long-lasting, impairments of motor function and thus cannot be regarded as a specific antinociceptive effect of the drug. These behavioural effects are considered to be probably due to direct spinal actions of the drug rather than antagonism of spinal substance P systems.
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D007278:Injections, Spinal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D000700:Analgesics; D013373:Substance P; C032132:substance P, prolyl(2)-tryptophan(7,9)-