Interaction of human beta-endorphin with the terminal SC5b-9 and "preterminal" SC5b-7 and SC5b-8 complexes of human complement.
Human beta-endorphin (beta H-EP) is demonstrated to bind to the "preterminal" SC5b-7 and SC5b-8 complexes and to the terminal SC5b-9 complex of human complement. Detailed binding studies revealed saturability, reversibility and structural specificity of the beta H-EP interaction with high or low affinity non-opiate binding sites on SC5b-7 and SC5b-9 complexes. The high affinity binding sites seem to be located predominantly on C5b, C6 or C7 subunits of the complexes.
D000510:Alpha-Globulins / Q000378:metabolism; D003182:Complement C5 / Q000378:metabolism*; D050776:Complement C5b; D015938:Complement Membrane Attack Complex; D003165:Complement System Proteins / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011485:Protein Binding; D013329:Structure-Activity Relationship; D001615:beta-Endorphin
D000510:Alpha-Globulins; D003182:Complement C5; D015938:Complement Membrane Attack Complex; D004723:Endorphins; C030931:SC5b-8; D001615:beta-Endorphin; D050776:Complement C5b; C037453:complement C5b-7 complex; D003165:Complement System Proteins