title: Changes in serum proteins following implantation of pacemakers.
abstract: The change in the protein concentration in blood serum was investigated after implantation of a pacing system with epoxide surface (group A, 20 patients) or metallic case (group B, 9 patients). The response to surgical intervention was equal in both groups. In the first period following operation the acute phase reaction took place in terms of increasing concentrations of alpha-globulins, especially alpha 1-acid glycoprotein, alpha 1-antitrypsin, ceruloplasmin, haptoglobin, and beta 1A/C-globulin, Simultaneously, a decrease in prealbumin, albumin, beta-globulin, in particular haemopexin and transferin concentration appeared. As for immunoglobulins, a decrease in IgG and increase in IgA and IgM globulins was observed. In the course of a longer period of time following implantation (group B--three months; group A--two years) a decrease of almost all investigated proteins was observed with exception of increased IgA globulin and transferin in group A.
mesh_terms: D000328:Adult; D000368:Aged; D000510:Alpha-Globulins / Q000032:analysis; D001609:Beta-Globulins / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis*; D002570:Ceruloplasmin / Q000032:analysis; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006466:Hemopexin / Q000032:analysis; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis; D010138:Pacemaker, Artificial; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors; D014168:Transferrin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000510:Alpha-Globulins; D001609:Beta-Globulins; D001798:Blood Proteins; D006242:Haptoglobins; D007136:Immunoglobulins; D009961:Orosomucoid; D012709:Serum Albumin; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D006466:Hemopexin; D002570:Ceruloplasmin