Tricyclic antidepressant use in a patient with bundle branch blocks and ventricular ectopy.
Amoxapine, a dibenzoxapine tricyclic antidepressant, was used successfully to treat a depressed elderly woman with left anterior hemiblock, right bundle branch block, and ventricular ectopy. This case highlights the importance of serial electrocardiographic monitoring in depressed patients with cardiac abnormalities treated with tricyclic antidepressants. The apparent reduction of ectopy in this case indicates a possible quinidine-like action of amoxapine.
D000657:Amoxapine / Q000494:pharmacology / Q000627:therapeutic use*; D002037:Bundle-Branch Block / Q000150:complications* / Q000503:physiopathology; D005117:Cardiac Complexes, Premature / Q000150:complications* / Q000503:physiopathology; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D003989:Dibenzoxazepines / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects
D003989:Dibenzoxazepines; D000657:Amoxapine