Protective effect of different mouse interferons in mice infected with encephalomyocarditis (EMC).
Antiviral activity of various preparations of mouse interferons (Mu-IFN) administered prophylactically by the intranasal route 4 h before intranasal infection of mice with EMC virus was studied. In spite of the same activity of Mu-IFN preparations in vitro, their antiviral effect in vivo displayed differences. The "alveolar" Mu-IFN induced with NDV obtained in the upper respiratory tract, appeared to be the most effective interferon preparation in the prophylaxis of viral infection in mice. Several-fold intranasal administration of "alveolar" interferon at 4-day intervals markedly increased the survival of animals intranasally infected with EMC.
D000818:Animals; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000517:prevention & control*; D007370:Interferon Type I / Q000494:pharmacology; D007372:Interferons / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011650:Pulmonary Alveoli / Q000276:immunology; D013997:Time Factors
D007370:Interferon Type I; D007372:Interferons