The origin of substance P in the rat submandibular gland and its major duct.
The origin of the substance P-like immunoreactivity in the rat submandibular gland and its major duct was investigated. Lesions severing the sympathetic, pre- and postganglionic parasympathetic and sensory innervation of the submandibular gland, or treatment with the neurotoxin capsaicin produced only a small non-significant decrease in the substance P-like immunoreactivity content of the gland. In contrast both sensory denervation and capsaicin treatment produced a substantial decrease in the content of substance P-like immunoreactivity in the major duct of the submandibular gland. These observations indicate that the duct innervation is clearly of sensory origin, whilst the substance P-like immunoreactivity of the gland itself appears to be intrinsic.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005455:Fluorescent Antibody Technique; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000166:cytology / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
D013373:Substance P; D002211:Capsaicin