Neuroanatomical localization of substance p: implications for central cardiovascular control.
The presence of substance P (SP) neurons in pathways known to be involved in the central control of the cardiovascular system has been studied with neuroanatomical and neurochemical techniques. SP-immunoreactive (SP-I) neurons are found in afferent baro- and chemoreceptor pathways which transmit information from peripheral receptors to the nucleus tractus solitarius. In addition, SP-I neurons located in the nucleus interfascicularis hypoglossi of the ventral medulla innervate the intermediolateral cell column, the site of origin of preganglionic sympthetic nerves. The role of these SP-I neurons in cardiovascular control remains to be determined.
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D002211:Capsaicin / Q000494:pharmacology; D002320:Cardiovascular Physiological Phenomena; D002628:Chemoreceptor Cells / Q000032:analysis; D006801:Humans; D009475:Neurons, Afferent / Q000032:analysis; D011311:Pressoreceptors / Q000032:analysis; D013373:Substance P / Q000032:analysis* / Q000502:physiology
D013373:Substance P; D002211:Capsaicin