Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen.
Anti-Id antisera generated to purified anti-HBs isolated from two different individuals recognized a common idiotype. This idiotype was detected in purified anti-Hbs preparations from three individuals and also in anti-HBs-positive sera obtained from six hemophilic patients. The ability of both HBsAg and a virus-derived HBsAg native polypeptide to inhibit the idiotype-anti-idiotype reaction suggested that the anti-HBs idiotype was associated with the antibody-combining site.
D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity; D001666:Binding Sites, Antibody; D000939:Epitopes; D006467:Hemophilia A / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D007130:Immunoglobulin Idiotypes
D000914:Antibodies, Viral; D000939:Epitopes; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D007130:Immunoglobulin Idiotypes