Antigen induced histamine release from mucosa in nasal polyposis.
This study was designed to detect local immediate-type hypersensitivity in patients with nasal polyposis. For this purpose, 20 patients were tested for antigen-induced histamine release from biopsies of nasal mucosa and nasal polyps. Compared with controls, histamine-release was increased after incubation with bacterial but not synthetic antigens. Fourteen patients allergic to pollen were studied; biopsy specimens of their nasal mucosa released more histamine on incubation with pollen than with synthetic antigens. These findings suggest that, like pollen allergy, nasal polyposis is a manifestation of immediate type hypersensitivity, possibly to bacterial antigens.
D000293:Adolescent; D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology*; D006632:Histamine / Q000378:metabolism; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000378:metabolism*; D007073:Immunoglobulin E / Q000276:immunology; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D009298:Nasal Polyps / Q000276:immunology / Q000378:metabolism*
D000942:Antigens, Bacterial; D007073:Immunoglobulin E; D006632:Histamine