Reorganization of the cytoskeleton by interferon in MSV-transformed cells.
beta and gamma interferons were found to enhance the organization of microfilaments, intermediate filaments, and fibronectin in the murine sarcoma virus (MSV)-transformed cell line. Furthermore, both interferons increased the number of intermediate-type junctions. Sodium butyrate was also found to act in a similar way and, when associated with interferon, an additive effect was observed. In the cell line, cultured for many passages in the presence of beta interferon (MSV-IF+), the cytoskeletal network and the extra-cellular matrix were highly developed and were reminiscent of a normal cell. These results could explain some of the biological actions of interferon, such as increased cell adhesion to the substratum and decreased cell motility.
D000199:Actins / Q000378:metabolism; D000818:Animals; D002087:Butyrates / Q000494:pharmacology; D002448:Cell Adhesion; D002460:Cell Line; D002472:Cell Transformation, Viral; D003599:Cytoskeleton / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D007365:Intercellular Junctions; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D009124:Muscle Proteins / Q000378:metabolism; D009053:Sarcoma Viruses, Murine; D014746:Vimentin
D000199:Actins; D002087:Butyrates; D005353:Fibronectins; D009124:Muscle Proteins; D014746:Vimentin; D007372:Interferons