title: Bidirectional axonal transport of thallium in frog sciatic nerve.
abstract: Bidirectional axonal transport of radioactivity was demonstrated in frog sciatic nerve in vitro and in vivo after local application of the thallium isotope 204Tl+ to the nerve. The transport rate was similar in both directions and about 30 min/day at 18 degrees C. The transport was depressed by 2,4-DNP, low-temperature and vinblastine. A somewhat larger amount of radioactivity was transported in the retrograde than in the anterograde direction. The possibility that K+ is in part replaced by Tl+, which is transported bound to organelles, e.g. mitochondria, will be considered. Thallium might be a useful tool for future studies of axonal transport.
mesh_terms: D019297:2,4-Dinitrophenol; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D004140:Dinitrophenols / Q000494:pharmacology; D011868:Radioisotopes; D011896:Rana temporaria; D012584:Sciatic Nerve / Q000502:physiology*; D013793:Thallium; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D004140:Dinitrophenols; D011868:Radioisotopes; D014747:Vinblastine; D013793:Thallium; D019297:2,4-Dinitrophenol