[Production of the hyporeactivity factor by mouse cells].
The mouse cells L 929 experiencing the state of hyporeactivity to repeated interferon induction with the aid of poly (I) X poly (C) secrete to the incubation medium a factor which suppresses interferon production. The factor is not neutralized by antiserum against murine interferon. Apart from hyporeactivity factor, interferon itself may inhibit its own production.
D000818:Animals; D003637:DEAE-Dextran / Q000494:pharmacology; D007372:Interferons / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D007739:L Cells / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D011070:Poly I-C / Q000494:pharmacology; D012097:Repressor Proteins / Q000096:biosynthesis*; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis*
D012097:Repressor Proteins; D014157:Transcription Factors; C024043:interferon repressor protein, mouse; D007372:Interferons; D003637:DEAE-Dextran; D011070:Poly I-C
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