Acrylamide-induced changes in the monoamines and their acid metabolites in different regions of the rat brain.
Acrylamide administration of 10 and 20 mg/kg body weight i.p. in the male rat induced alteration in the levels of dopamine (DA), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) in different regions of the brain. Selective but widespread changes were observed in 5-HIAA levels in all regions of the brain studied. 5-HT levels were significantly increased in the brain stem. The DA content also showed a significant increment in the caudate nucleus. These data suggested that the neurotoxicity of acrylamide might be correlated with the overall disturbances of serotonergic system.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D010648:Phenylacetates / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D012701:Serotonin / Q000378:metabolism*; D014018:Tissue Distribution
D000178:Acrylamides; D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; D020106:Acrylamide; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid