title: Bronchospasm mechanisms in experimental microbial sensitization. II. Pathochemical stage.
abstract: The pathochemical mechanisms of bronchospasm have been studied using various type of experimental allergies to microbial antigens. It was established that in guinea pigs with type I allergies isolated lung bronchospasm was mediated by histamine and SRS-A. Bronchial response to immune complexes type III were produced by the activation of complement with subsequent degranulation of mast cells and histamine release. Type IV hypersensitivity (lymphokine-mediated bronchospasm) was manifested without histamine, acetylcholine and mast cell involvement. The response to lymphokine was blocked by atropine. The spasmogenic y lymphokines are large molecular thermolabile substances.
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001285:Atropine / Q000494:pharmacology; D012898:Autacoids / Q000276:immunology; D001980:Bronchi / Q000187:drug effects; D001986:Bronchial Spasm / Q000276:immunology*; D003167:Complement Activation; D004155:Diphenhydramine / Q000494:pharmacology; D006168:Guinea Pigs; D006636:Histamine Release; D006967:Hypersensitivity / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats
chemical_list: D000485:Allergens; D000942:Antigens, Bacterial; D012898:Autacoids; D008222:Lymphokines; D001285:Atropine; D004155:Diphenhydramine