Cytoplasmic blood plasma inclusions in human hepatocytes.
Hepatocellular blood plasma inclusions were demonstrated in conventional formalin-fixed paraffin-embedded liver tissue by the immunoperoxidase technique in 114 out of 197 liver specimens. They were usually round or elliptical in shape, their size varying from a few microns to about 30 microns in diameter. Albumin, fibrinogen, alpha 1-antitrypsin, IgG, IgM, IgA, ceruloplasmin and transferrin were demonstrated in the inclusions, in that order of frequency. A majority were negative with the periodic acid Schiff stain after amylase digestion, but a few were positive. Many of them seemed to correspond to vacuoles in the hepatocytes but some were not seen in HE-stained sections. The inclusions were frequently seen in autopsy liver specimens, but were rare in surgical ones. Most of the inclusions might develop at an agonal stage, probably as a result of hypoxia or circulatory disturbances in the livers.
D000328:Adult; D000368:Aged; D001706:Biopsy; D001798:Blood Proteins / Q000032:analysis*; D002570:Ceruloplasmin / Q000032:analysis; D003594:Cytoplasmic Granules / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis; D002479:Inclusion Bodies / Q000032:analysis*; D008099:Liver / Q000032:analysis / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis; D013194:Staining and Labeling; D014168:Transferrin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D001798:Blood Proteins; D007136:Immunoglobulins; D012709:Serum Albumin; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D005340:Fibrinogen; D002570:Ceruloplasmin