Synthesis and biological activity of glycosylated analogs of the C-terminal hexapeptide and heptapeptide of substance P.
The synthesis of two glycosylated analogs of Substance P is described. The activity of the peptides was assayed on the isolated guinea-pig ileum and their degradation was studied using rat hypothalamus slices. While glycosylation noticeably enhances the solubility of the corresponding compounds, the beta-glucopyranosyl moiety only slightly modifies the biological half-life and the bioactivity of the glycopeptides.
D000818:Animals; D001681:Biological Assay; D006020:Glycopeptides / Q000138:chemical synthesis*; D006168:Guinea Pigs; D007031:Hypothalamus / Q000378:metabolism; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D013373:Substance P / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D006020:Glycopeptides; D007202:Indicators and Reagents; D013373:Substance P