Hb F-Columbus-Ga or alpha 2 G gamma 2 94(FGl) Asp replaced by Asn.
A new gamma chain variant with an electrophoretic mobility at pH 8.1 between those of Hb S and Hb C was isolated and quantitated by DEAE-cellulose chromatography. It was readily identified with the use of various micro-chromatographic and sequencing procedures as alpha 2 G gamma 2 94(FGl)Asp replaced by Asn. The hemoglobin was named Hb F-Columbus-Ga. The quantity of this G gamma chain variant (as % total gamma chain) was about 39% and the percentages of the normal G gamma and A gamma I chains were 37% and 24%, respectively.
D000595:Amino Acid Sequence; D002848:Chromatography, DEAE-Cellulose; D005312:Fetal Blood / Q000032:analysis; D005319:Fetal Hemoglobin / Q000302:isolation & purification*; D006455:Hemoglobins, Abnormal / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn
D006455:Hemoglobins, Abnormal; C036999:hemoglobin F Columbus-Ga; D005319:Fetal Hemoglobin