Lack of identity between the 90K protective glycoprotein of Trypanosoma cruzi and hybridoma (CE5)-defined T. cruzi antigen which cross reacts with mammalian neurones.
The monoclonal antibody (CE5) which recognizes cross reacting antigenic determinants on mammalian neurones and T. cruzi parasites has here been shown to react with whole T. cruzi but not with the 90K cell surface glycoprotein fraction. Thus, the 90K glycoprotein which is protective in experimental vaccination studies lacks identity with the potentially pathogenic antigen determinants defined by CE5.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology; D009474:Neurons / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D006023:Glycoproteins; D008565:Membrane Proteins