High incidence of beta-2-microglobulin containing macromolecular complexes in sarcoidosis sera.
In thirteen out of fourteen sarcoidosis patients with elevated serum levels of immune complexes beta-2-microglobulin (beta 2m) was detected in immune complex-enriched fractions prepared by precipitation with 3% polyethylene glycol. Beta-2-microglobulin was also contained in complexes isolated by means of solid-phase Clq. The levels of free beta 2m in sarcoidosis sera did not differ from the concentrations in sera from healthy donors.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001609:Beta-Globulins / Q000032:analysis*; D005260:Female; D006801:Humans; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000494:pharmacology; D012507:Sarcoidosis / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000032:analysis* / Q000276:immunology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D001609:Beta-Globulins; D046911:Macromolecular Substances; D001613:beta 2-Microglobulin; D011092:Polyethylene Glycols