title: A viral coat glycoprotein (gp52MuMTV) has detergent-sensitive and detergent-resistant epitopes in the same molecule.
abstract: Two monoclonal antibodies (IIB5 and IC12) specific for the gp52 coat glycoprotein of mouse mammary tumor virus are directed against epitopes on the gp52 that are sensitive to a non-ionic detergent, Nonidet P-40. There are other epitopes on this molecule that are stable in the detergent, as seen in immunoprecipitation studies with other anti-gp52 monoclonal antibodies (VE7, IIIA1, IVC11).
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D003902:Detergents / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D017830:Octoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D003902:Detergents; D000939:Epitopes; D014759:Viral Envelope Proteins; D011092:Polyethylene Glycols; D017830:Octoxynol; C010615:Nonidet P-40