Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides.
A cyclic peptide containing the amino acid sequence 122 through 137 of the major hepatitis B surface antigen (HBsAg) polypeptide was synthesized. The immunogenicity of this synthetic peptide, aggregated in micelles or covalently coupled to tetanus toxoid, was assessed in mice. Antibodies against HBsAg (anti-HBs) were obtained with both preparations, administered either in saline suspension or adsorbed on aluminum gel. The peptide-tetanus toxoid conjugate was more immunogenic than the peptide micelles, producing high levels of specific anti-HBs.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000939:Epitopes; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D051379:Mice; D010446:Peptide Fragments / Q000276:immunology; D010455:Peptides / Q000138:chemical synthesis; D013329:Structure-Activity Relationship; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D000939:Epitopes; D006514:Hepatitis B Surface Antigens; D010446:Peptide Fragments; D010455:Peptides; D014765:Viral Vaccines