Human beta interferon gene localization and expression in somatic cell hybrids.
The human fibroblast interferon gene beta 1 was mapped to human chromosome 9. Sequence homology with a beta 1 cDNA clone was detected in both genomic DNA and induced mRNA of human/mouse or human/hamster somatic cell hybrids containing human chromosome 9, but not in lines lacking this chromosome or those retaining a complex translocation involving chromosomes 9 and 11. Interferon mRNA that did not share sequence homology with the beta 1 cDNA clone was detected in lines containing human chromosomes 2 and 5 but lacking chromosome 9, suggesting the presence of other unlinked interferon sequences in the human genome.
D000818:Animals; D001483:Base Sequence; D002906:Chromosomes, Human, 6-12 and X; D006224:Cricetinae; D004247:DNA / Q000032:analysis; D005347:Fibroblasts; D005786:Gene Expression Regulation; D006801:Humans; D006822:Hybrid Cells; D007372:Interferons / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D014178:Translocation, Genetic
D012333:RNA, Messenger; D004247:DNA; D007372:Interferons