Developmental pattern of beta-chain production at midtrimester pregnancy in Sardinian beta o-thalassemia heterozygotes.
This study shows a minor, statistically non significant increase, of beta-chain synthesis from 18 to 24 weeks gestation in both normal and beta o-thalassemia heterozygous fetuses with no significant changes in the ratio between the values for the two groups as a function of gestational age. This result indicates that at midtrimester pregnancy the developmental pattern of Hb F to Hb A switching in beta o-thalassemia heterozygotes is similar to that of normal fetuses.
D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005319:Fetal Hemoglobin / Q000032:analysis*; D005865:Gestational Age; D006441:Hemoglobin A / Q000032:analysis* / Q000096:biosynthesis; D006579:Heterozygote; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013789:Thalassemia / Q000097:blood*
D006441:Hemoglobin A; D005319:Fetal Hemoglobin