Pruritic dermatitis in asthmatic basenji-greyhound dogs: a model for human atopic dermatitis.
A recurrent, nonseasonal pruritic dermatitis manifested as lichenified plaques and as inflammatory nodules and papules in each of fourteen basenji-greyhound (B-G) crossbreed dogs, all of which demonstrated both nonspecific and Ascaris-specific airway hyperreactivity, with changes in pulmonary mechanics of the same order as those seen in symptomatic human asthma. Other features analogous to human atopic disease included blunted cyclic adenosine monophosphate (cAMP) responsiveness to beta adrenergic agents and in vivo release of histamine and slow-reacting substance of anaphylaxis in response to antigen aerosol challenge. The dermatitis appears to be a manifestation of the atopic state in these dogs and may provide an animal model for the study of human atopic dermatitis.
D000818:Animals; D001200:Ascaris / Q000276:immunology; D001249:Asthma / Q000503:physiopathology / Q000662:veterinary*; D000242:Cyclic AMP / Q000378:metabolism; D003872:Dermatitis / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D003876:Dermatitis, Atopic / Q000503:physiopathology; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D006636:Histamine Release; D006801:Humans; D012867:Skin / Q000473:pathology
D000242:Cyclic AMP