Effect of lensectomy on the movement of tracers from vitreous to aqueous.
To investigate the effect of extracapsular lensectomy with posterior capsulotomy, 20,000- and 70,000-dalton dextran was injected into the vitreous of rabbits. The concentration of the 20,000-dalton dextran in the aqueous of aphakic eyes was 14-fold greater than in phakic eyes 3.5 hours after injection of dextran into the vitreous. The aqueous concentration of the 70,000-dalton dextran was four times greater in aphakic eyes after 3.5 hours. The aqueous concentration of a 20,000-dalton dextran in phakic and aphakic eyes became equal between 15.5 and 22.0 hours after injection. Thus, extracapsular lensectomy with posterior capsulotomy increased the rate of movement of a single bolus of both 20,000- and 70,000-dalton dextran preparations from the vitreous to the anterior chamber.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D003911:Dextrans / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000473:pathology; D005123:Eye / Q000098:blood supply; D007903:Lens Capsule, Crystalline / Q000601:surgery; D007908:Lens, Crystalline / Q000502:physiology / Q000601:surgery*; D009389:Neovascularization, Pathologic / Q000473:pathology; D011817:Rabbits; D014822:Vitreous Body / Q000378:metabolism*
D003911:Dextrans