Evidence for the existence of a substance P-containing pathway from the nucleus laterodorsalis tegmenti (Castaldi) to the medial frontal cortex of the rat.
A long ascending substance P (SP)-containing pathway from the nucleus laterodorsalis tegmenti (TLD) to the medial frontal cortex (MFC) has been demonstrated by means of experimental immunohistochemical procedures. The unilateral destruction of the TLD, which contains numerous SP-like immunoreactive (SPLI) cells, resulted in a marked ipsilateral decrease in the SPLI fibers in the MFC.
D000344:Afferent Pathways / Q000033:anatomy & histology; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D005455:Fluorescent Antibody Technique; D005625:Frontal Lobe / Q000033:anatomy & histology* / Q000378:metabolism; D006735:Horseradish Peroxidase; D008297:Male; D051381:Rats; D013373:Substance P / Q000378:metabolism*; D013681:Tegmentum Mesencephali / Q000033:anatomy & histology* / Q000378:metabolism
D013373:Substance P; D006735:Horseradish Peroxidase