[Changes in the reflex discharges and electrotonic potentials of spinal nerve roots in the rat upon exposure to biologically active substances].
The ionic nature of neuronal postsynaptic responses to monoamines, aminoacids and the substance P was studied in the newborn rat isolated spinal cord. The responses of motoneurons to GABA, glycine, noradrenaline and dopamine appeared to be Cl-dependent. The depolarization of motoneurons induced by L-glutamate and 5-hydroxytryptamine was Na-dependent whereas the same response to the substance P was Cl-dependent. Primary afferent depolarization with GABA is Cl-dependent whereas if induced by glycine and 5-hydroxytryptamine it is Na-dependent. Neurochemical and ionic profiles of mono- and polysynaptic ventral and dorsal root potentials are discussed.
D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D018698:Glutamic Acid; D005998:Glycine / Q000494:pharmacology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013126:Spinal Nerve Roots / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005971:Glutamates; D012701:Serotonin; D013373:Substance P; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D005998:Glycine; D004298:Dopamine; D009638:Norepinephrine
Izmeneniia reflektornykh razriadov i élektrofiziologicheskikh potentsialov koreshkov izolirovannogo spinnogo mozga krys pod vliianiem biologicheski aktivnykh veshchestv.