title: Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. XIV. Carrier requirement for suppressor cell induction.
abstract: The carrier requirements for the induction of helper and suppressor T (Ts) cells were compared. Although H-2-linked Ir genes control the development of helper T cells and hapten-specific B cells, they do not influence Ts3 generation. That is, GL phi nonresponder C57BL/6 mice can generate NP-specific Ts3 cells after priming with NP-GL phi. The Ts3 cells generated under these conditions are functionally and phenotypically identical to the NP-specific Ts3 cells previously characterized. Furthermore, these Ts3 populations can be specifically depleted with a monoclonal anti-idiotope antibody prepared against monoclonal anti-NP antibodies. By using related polymers, carrier effects on Ts3 induction were noted. NP-D-GL and NP-Ficoll failed to induce Ts3 cells, whereas NP-L-GL induced this suppressor subset. The data demonstrate that Ts3 induction is independent of the carrier requirements involved in helper T cell induction and is not dependent upon B cell priming. The implications of these results with regard to the mechanisms of Ts3 induction are discussed.
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology*; D000939:Epitopes; D006241:Haptens / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009596:Nitrophenols / Q000276:immunology*; D010641:Phenotype; D010648:Phenylacetates; D011099:Polyglutamic Acid / Q000276:immunology / Q000031:analogs & derivatives; D011107:Polylysine / Q000276:immunology / Q000031:analogs & derivatives; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology*
chemical_list: D000941:Antigens; D002352:Carrier Proteins; D000939:Epitopes; D006241:Haptens; D009596:Nitrophenols; D010648:Phenylacetates; C030459:poly(Glu(56)Lys(35)Phe(9))(GLphi) antigen; C026242:4-hydroxy-5-nitrophenyl acetic acid; D011107:Polylysine; D011099:Polyglutamic Acid; C030391:poly(glutamic acid-lysine)