Deficiency of interferon-gamma but not interferon-beta in Arabian foals with severe combined immunodeficiency.
The results of a study on the induction of IFN-alpha, IFN-beta, and IFN-gamma in normal and SCID foals showed a deficiency of IFN-gamma but not IFN-beta in SCID foals. The ability of SCID mononuclear cells to produce IFN-alpha in response to poly I:C but not to NDV may indicate a partial deficiency of IFN-alpha in SCID foals. The deficiency of IFN-gamma and presence of IFN-beta in SCID foals supports the classification of IFN-gamma and IFN-beta as immune and nonimmune interferons, respectively. Furthermore, the deficiency of IFN-gamma in SCID foals may in part explain the high susceptibility to infections observed in SCID foals.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006734:Horse Diseases / Q000276:immunology*; D006736:Horses; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000662:veterinary*; D007372:Interferons / Q000096:biosynthesis* / Q000172:deficiency; D009000:Monocytes / Q000276:immunology
D003208:Concanavalin A; D007372:Interferons