Effect of anti-allergic and cyclic AMP-active drugs on histamine secretion from rat mast cells treated with the novel calcium ionophore chlortetracycline.
The anti-allergic drugs disodium cromoglycate, doxantrazole and quercetin, and a number of compounds known to elevate intracellular levels of cyclic AMP, inhibited histamine secretion from rat peritoneal mast cells stimulated with the novel calcium ionophore, chlortetracycline. The potency of the compounds varied inversely with the concentration of ionophore. The activity of the drugs cannot be explained in terms of their postulated effect on the receptor-mediated activation of calcium channels in the mast cell membrane. Alternative mechanisms for their action are thus considered.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002751:Chlortetracycline / Q000494:pharmacology*; D004205:Cromolyn Sodium / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013892:Thioxanthenes / Q000494:pharmacology*; D044004:Xanthones
D005419:Flavonoids; D010726:Phosphodiesterase Inhibitors; D011458:Prostaglandins E; D013892:Thioxanthenes; D044004:Xanthones; D003994:Bucladesine; D011794:Quercetin; D004205:Cromolyn Sodium; C010134:doxantrazole; D002751:Chlortetracycline