[Effect of ribonuclease on the development of experimental osteoporosis in animals of various ages].
Studies were undertaken on the effect of intravenously administered ribonuclease agent on the development of experimental osteoporosis produced by cutting of N. femoralis and N. obturatorius in rabbits of different ages. It was found that after chronic (4 months) intravenous ribonuclease administration the osteoporosis of femoral bone stopped to develop in the operated rabbits. The effect of ribonuclease on the RNA synthesized in the conditions of denervation and resulting in activation of the pathological process may be suggested.
D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D005269:Femur / Q000201:enzymology; D010024:Osteoporosis / Q000201:enzymology*; D012313:RNA / Q000378:metabolism; D011817:Rabbits; D012260:Ribonucleases / Q000494:pharmacology*
D012313:RNA; D012260:Ribonucleases
Einwirkung der Ribonuklease auf die Entwicklung experimenteller Osteoporose bei Tieren unterschiedlichen Alters.