The clinical significance of a sinusoidal fetal heart rate pattern associated with alphaprodine administration.
A prospective analysis of 34 patients in active labor who were given alphaprodine for analgesia revealed a 32% incidence of sinusoidal fetal heart rate patterns (SFHRP). In a control group of 27 patients who did not receive narcotic analgesia, 1 patient (3.7%) showed a sinusoidal pattern. All study infants, with one exception, who developed SFHRP had a one-minute Apgar score of 7 or greater. Alphaprodine is believed to affect the fetal cardioregulatory center in such a manner as to cause the SFHRP but seems to cause no increase in perinatal morbidity or mortality when given in nontoxic doses.
D000522:Alphaprodine / Q000009:adverse effects*; D001034:Apgar Score; D005260:Female; D005333:Fetus / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric; D010166:Palliative Care; D011247:Pregnancy
D000522:Alphaprodine