Lymphocyte responses to an aqueous extract from cow hair and dander. Investigations of asthmatics and normal controls with lymphocyte transformation tests.
The proliferative responsiveness to cow dander antigens of lymphocytes from 23 asthmatic patients with allergy to cow hair and dander, from 10 patients with allergic asthma to other antigens and from 31 non-atopic subjects was investigated. Lymphocytes from patients with allergic asthma due to cow epithelium antigens showed a statistically significant decreased responsiveness to an extract from cow dander, compared to that seen with lymphocytes from newborn infants, lymphocytes from normal controls and from asthmatic patients without allergy to cow. The response to the cow dander extract seemed to be an accessory cell dependent T lymphocyte response.
D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000276:immunology*; D002417:Cattle; D000939:Epitopes; D006197:Hair / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens; D000939:Epitopes; D010835:Phytohemagglutinins; D007073:Immunoglobulin E