Modulation of lysophosphatidylserine-dependent histamine release.
Apomorphine (2-30 microM) inhibits lysophosphatidyl-serine-dependent histamine release in rat and mouse peritoneal mast cells. The drug-induced inhibition is influenced by the concentration of lysophosphatidylserine. Log concentration-response curves show a surmountable type of antagonism between the two compounds.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008246:Lysophospholipids; D008407:Mast Cells / Q000378:metabolism*; D051379:Mice; D009414:Nerve Growth Factors / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology*; D051381:Rats
D008246:Lysophospholipids; D009414:Nerve Growth Factors; D010718:Phosphatidylserines; C025059:lysophosphatidylserine; D001058:Apomorphine