Immunocytochemical identification of serotonin axonal contacts on characterized neurons in laminae I and II of the cat dorsal horn.
Serotonergic pathways from brainstem to spinal cord play an important role in the modulation of pain perception. To establish where that modulation occurs, we examined serotonin-immunoreactive axonal contacts on individually characterized laminae I and II dorsal horn neurons intracellularly filled with horseradish peroxidase. We found serotonin axonal contacts on marginal, stalked, and islet cells. Contacts preferentially occurred on dendritic shafts rather than on spines. Marginal and stalked cells received the heaviest innervation.
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000648:ultrastructure; D001933:Brain Stem / Q000378:metabolism*; D002415:Cats; D003712:Dendrites / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism*; D008854:Microscopy, Electron; D009434:Neural Pathways / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009619:Nociceptors / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin