The dopamine agonist bromocriptine induces hypotension by venous and arteriolar dilation.
Acute bromocriptine administration reduced sitting and standing blood pressure and produced severe orthostatic hypotension in 12 normal subjects. Concomitantly, there was an increase in venous distensibility and basal blood flow, and a decrease in peripheral vascular resistance, as determined by forearm plethysmography. After administration of bromocriptine, plasma norepinephrine concentration decreased. Bromocriptine lowers blood pressure by dilating arterioles and veins, at least in part by means of dopaminergic inhibition of sympathetic nervous system activity.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001160:Arterioles / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D001971:Bromocriptine / Q000009:adverse effects / Q000494:pharmacology*; D002395:Catecholamines / Q000097:blood; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010991:Plethysmography; D011388:Prolactin / Q000097:blood; D012083:Renin / Q000097:blood; D013564:Sympathetic Nervous System / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*; D014680:Veins / Q000187:drug effects
D002395:Catecholamines; D001971:Bromocriptine; D000450:Aldosterone; D011388:Prolactin; D012083:Renin; D004298:Dopamine