[Antigenic structure of normal and malignant breast tissue].
The study was concerned with 13 antigens identified with the aid of a set of immune sera obtained from rabbits immunized with a nuclear, a membrane and a soluble fractions of normal and malignant mammary tissues as well as with the membranes of fat globules of breast milk. The antigens (1 nuclear, 4 soluble and 8 membraneous) were of different specificity: four--occurring in many organs, two--specific for milk only, three--organ-specific antigens which, however, persist in malignant tissues, and one--present in malignant tissue and absent from normal mammary and 25 other tissues tested. Such antigens as lactoferrin and alpha-lactalbumin were identified by immuno-enzymatic methods in the sera of a third of patients with tumors of different localizations.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D001940:Breast / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008895:Milk, Human / Q000276:immunology; D011817:Rabbits
D000941:Antigens; D000951:Antigens, Neoplasm; D000939:Epitopes
Izuchenie antigennoĭ struktury normal'nykh i malignizirovannykh tkaneĭ molochnoĭ zhelezy.