Antigen-specific non-immunoglobulin "antibody'-like molecules in rhesus monkey serum.
The presence (in sera of rhesus monkeys) of four antigen-specific molecules with different electrophoretic mobilities apart from conventional immunoglobulins has been recognized. Rhesus monkeys have been primed with rabbit erythrocytes (RRBC) and the antigen-specific molecules in the serum have been fished out by absorption onto RRBC. Antisera have been raised in rabbits against such molecules and analysed by immunoelectrophoresis. The antigen-binding property of the four molecules, which do not resemble conventional immunoglobulins has been confirmed by enzyme immunoelectrophoresis. The possibility of these molecules being products of T lymphocytes in the light of observations reported in recent years is discussed.
D000510:Alpha-Globulins / Q000032:analysis* / Q000276:immunology; D000818:Animals; D001609:Beta-Globulins / Q000032:analysis* / Q000276:immunology; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007122:Immunoelectrophoresis; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000097:blood / Q000276:immunology*; D008297:Male; D011817:Rabbits; D005719:gamma-Globulins / Q000032:analysis* / Q000276:immunology
D000510:Alpha-Globulins; D001609:Beta-Globulins; D000939:Epitopes; D005719:gamma-Globulins