title: Cells participating in immunologic memory induced with RNA from the spleens of immunized mice.
abstract: Ribonucleic acid (immune RNA, iRNA) extracted from the spleens of mice immunized with heterologous red blood cells induced antigen-specific immunologic memory. The type of cells (T cells, B cells) which participate in immunologic memory induced with iRNA was investigated. Immune RNA-primed T cells cooperated with normal, iRNA-primed or antigen-primed B cells and induced a high IgM response. Immune RNA-primed B cells did not cooperate with normal T cells, but did with iRNA- or antigen-primed T cells. The activities of iRNA-primed T and B cells were antigen-specific.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D007114:Immunization; D007116:Immunization, Passive; D007075:Immunoglobulin M; D007156:Immunologic Memory; D008211:Lymphocyte Cooperation; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D012313:RNA / Q000276:immunology*; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007075:Immunoglobulin M; C013674:RNA, immune; D012313:RNA