Fractional hepatic localization of 14CHCl3 in mice and rats treated with chlordecone or mirex.
In rodents chlordecone, but not mirex, a nonketonic structural analog, significantly augments CHCl3-induced liver damage, at least in part, by increasing CHCl3 bioactivation. To determine whether the fractional distribution of CHCl3 was altered in chlordecone-pretreated animals, the irreversible binding of 14CHCl3 to various liver constituents (a measure of CHCl3 bioactivation) was examined in vivo in mice and rats. Chlordecone, but not mirex, increased both total and irreversibly bound 14CHCl3; furthermore, changes in the 14C localization between lipid, protein and acid-soluble fractions were noted. Thus, the results suggest that differences exist between chlordecone and mirex with respect to their capacity to increase the quantity of CHCl3-derived reactive metabolite and the eventual distribution of reactive metabolite.
D000818:Animals; D002250:Carbon Radioisotopes; D007631:Chlordecone / Q000633:toxicity*; D002725:Chloroform / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008917:Mirex / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D007306:Insecticides; D002725:Chloroform; D003577:Cytochrome P-450 Enzyme System; D007631:Chlordecone; D008917:Mirex