title: [Planning of the treatment of atypical hyperplasia of the endometrium in patients with uterine myoma].
abstract: The results of a two-stage hormonal treatment of 62 cases of atypical hyperplasia of the endometrium were analysed. Within the first 6 months, patients received 24.0-28.0 g of hydroxyprogesterone capronate each. Six courses of steroid contraceptives such as non-ovlon and bisecurin were given during the second stage when regression of endometrial precancer had already been registered. The results proved hormonal therapy to be highly effective in managing atypical hyperplasia of the endometrium. Complete response was observed in 67.7% of patients. Coexistent uterine myoma affected the efficacy of treatment adversely: only 4 out of 14 patients with atypical hyperplasia of the endometrium with concomitant myoma were good responders. Hormonal treatment was ineffective mainly in cases of myoma of sizes exceeding 8 weeks of gestation and in pre- and postmenopausal patients. This makes the case for surgery.
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D000367:Age Factors; D002715:Chlormadinone Acetate / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage; D004107:Dilatation and Curettage; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004714:Endometrial Hyperplasia / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D005040:Ethynodiol Diacetate / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000008:administration & dosage; D007889:Leiomyoma / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D008656:Mestranol / Q000008:administration & dosage; D008875:Middle Aged; D009640:Norethindrone / Q000008:administration & dosage; D013997:Time Factors; D014594:Uterine Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery
chemical_list: D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; D006908:Hydroxyprogesterones; D002715:Chlormadinone Acetate; D000077713:17 alpha-Hydroxyprogesterone Caproate; C010260:Non-Ovlon; D005040:Ethynodiol Diacetate; C018467:Bisecurin I; D008656:Mestranol; D009640:Norethindrone
vernacular_title: Planirovanie lecheniia atipicheskoĭ giperplazii éndometriia u bol'nykh miomoí matki.