Study of cell-surface markers in chronic lymphocytic leukaemia (CLL).
There are new possibilities to characterize lymphocytes of the so-called immunoproliferative disorders, e.g. chronic lymphocytic leukaemia. Cell marker studies help to phenotype and differentiate several entities within the CLL-syndrome. Test of rosette formation with mouse erythrocytes together with the surface membrane immunoglobulin detection by immunofluorescence technique proved to be very useful in diagnosing B-CLL and in distinguishing it from other B-lymphoproliferative disorders. In three patients with atypical B-CLL the number of dual-marked (D)-lymphocytes were increased significantly. The prognostic value of this phenomenon is still uncertain.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000276:immunology*; D051379:Mice / Q000276:immunology; D010641:Phenotype; D011947:Receptors, Antigen, B-Cell / Q000032:analysis* / Q000276:immunology; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D011947:Receptors, Antigen, B-Cell