Possible role of oxidized glutathione for the regulation of the myocardial hexose monophosphate shunt.
Infusion of the isolated perfused Langendorff rat heart with tert-butyl hydroperoxide (3 X 10(-4) M) resulted in a marked enhancement of the concentration of oxidized glutathione, in an increase of the NADP+/NADPH ratio, and in an elevation of the available pool of 5-phosphoribosyl-1-pyrophosphate, which is one of the end products of the hexose monophosphate shunt. Since it has been shown that oxidized glutathione overcomes the inhibition of glucose-6-phosphate dehydrogenase exerted by NADPH, these results suggest that the myocardial hexose monophosphate shunt can be stimulated rapidly and markedly through this control mechanism.
D000818:Animals; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006600:Hexosephosphates / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D009249:NADP / Q000378:metabolism; D010754:Phosphoribosyl Pyrophosphate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012267:Ribosemonophosphates / Q000378:metabolism
D006600:Hexosephosphates; D012267:Ribosemonophosphates; C031626:ribose-5-phosphate; D009249:NADP; D010754:Phosphoribosyl Pyrophosphate; D005954:Glucosephosphate Dehydrogenase; D005978:Glutathione