Study of nucleolar organizer in women with galactorrhea, or polycystic ovaries, or using oral contraceptive.
In this paper we report on changes of the Ag-stained NOR (Ag-NOR) and Ag-stained acrocentric association (Ag-AA) frequencies in lymphocytes of women with polycystic ovaries, galactorrhea, or taking oral contraceptives. The results showed that Ag-AA frequencies were increased significantly in all three study groups while the Ag-NOR frequencies apparently did not increase. We assume that a difference in average Ag-NOR frequency between the two groups may be a measure of the change in the number of active rRNA genes, and that differences of Ag-AA frequency among populations reflect the change in transcriptional rate of the active rRNA genes.
D000328:Adult; D003276:Contraceptives, Oral; D005260:Female; D005687:Galactorrhea / Q000235:genetics*; D006801:Humans; D007775:Lactation Disorders / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D009640:Norethindrone; D009697:Nucleolus Organizer Region; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011247:Pregnancy; D012335:RNA, Ribosomal / Q000235:genetics; D012834:Silver; D013194:Staining and Labeling; D014158:Transcription, Genetic
D003276:Contraceptives, Oral; D012335:RNA, Ribosomal; D012834:Silver; D009640:Norethindrone