Characterisation of brain D2 dopamine receptors solubilised by lysophosphatidylcholine.
Brain D2 dopamine receptors have been solubilised using lysophosphatidylcholine. The inclusion of proteinase inhibitors during solubilisation enables a preparation to be obtained containing a high proportion of solubilised D2 receptors with pharmacological properties similar to those of membrane-bound D2 receptors.
D000818:Animals; D001667:Binding, Competitive; D001923:Brain Chemistry; D002069:Butaclamol / Q000378:metabolism; D002417:Cattle; D002421:Caudate Nucleus / Q000032:analysis; D008244:Lysophosphatidylcholines; D011480:Protease Inhibitors / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000302:isolation & purification* / Q000378:metabolism; D017448:Receptors, Dopamine D2; D012995:Solubility; D013134:Spiperone / Q000378:metabolism
D008244:Lysophosphatidylcholines; D011480:Protease Inhibitors; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013134:Spiperone; D002069:Butaclamol