Risk factors of anesthesia and surgery in bleomycin-treated patients.
The use of bleomycin as part of preoperative chemotherapy regimens for nonseminomatous germ cell tumors of the testis has gained increased acceptance. However, recent experience has suggested that patients so treated are at an increased risk of developing postoperative respiratory distress syndrome. The most clearly associated factor seems to be the fractional concentration of inspired oxygen intraoperatively and in the immediate postoperative period. Based on our experience and a review of the limited published reports, we recommend careful monitoring of fractional inspired oxygen and maintenance of the lowest tolerated oxygen concentration during this period.
D000328:Adult; D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects* / Q000627:therapeutic use; D004357:Drug Synergism; D004407:Dysgerminoma / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000009:adverse effects; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology*; D012306:Risk; D013736:Testicular Neoplasms / Q000601:surgery
D001761:Bleomycin; D010100:Oxygen