Enzyme studies in human prostatic tissues.
The activities of six enzymes associated with carbohydrate metabolism were measured in 24 benign prostatic hyperplasias and 29 carcinomas of the prostate with the intention of investigating whether these measurements might eventually predict the clinical course of the disease. The following findings are recorded: the activities of PFK, alpha-GPDH and PHI were significantly lower in carcinomas. Comparison between well and poorly-differentiated carcinomas indicated a significantly lower activity of 6PGDH and higher alpha-GPDH/6PGDH ratios in the latter. These findings are the opposite of those observed in carcinomas of the breast.
D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology; D004247:DNA / Q000032:analysis; D005956:Glucose-6-Phosphate Isomerase / Q000032:analysis; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis; D005993:Glycerolphosphate Dehydrogenase / Q000032:analysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010732:Phosphofructokinase-1 / Q000032:analysis; D010734:Phosphogluconate Dehydrogenase / Q000032:analysis; D011470:Prostatic Hyperplasia / Q000201:enzymology*; D011471:Prostatic Neoplasms / Q000201:enzymology*; D014021:Tissue Preservation
D004247:DNA; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D010732:Phosphofructokinase-1; D005956:Glucose-6-Phosphate Isomerase