TFP inhibits the expression of the endogenous platelet lectin and secretion of alpha-granules.
Activated platelets that have not undergone secretion do not express the endogenous platelet lectin whereas activated platelets that have undergone secretion do express this lectin. Expression of the lectin, secretion of beta-TG and PF-4, and secondary aggregation are inhibited by TFP. These results demonstrate that expression of the endogenous platelet lectin is apparently secretion dependent. Our results also reveal that inhibition of platelet aggregation by TFP apparently is not caused by inhibition of secretion and that there are TFP sensitive and TFP insensitive mechanisms of secretion.
D001609:Beta-Globulins / Q000378:metabolism*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001792:Blood Platelets / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism; D006384:Hemagglutination; D006801:Humans; D037102:Lectins / Q000032:analysis*; D010974:Platelet Aggregation / Q000187:drug effects*; D010978:Platelet Factor 4 / Q000378:metabolism*; D014268:Trifluoperazine / Q000494:pharmacology*; D001620:beta-Thromboglobulin / Q000378:metabolism*
D001609:Beta-Globulins; D001779:Blood Coagulation Factors; D037102:Lectins; D001620:beta-Thromboglobulin; D014268:Trifluoperazine; D010978:Platelet Factor 4