[Induction of infectious Friend virus after treatment with 5-azacytidine of a non-virus-producing erythroleukemia line (HFL/b)].
A Friend virus induced erythroleukemia cell line (HFL/b cells) did not produce infectious MuLV and only expressed the defective SFFV component of Friend virus (SFFV (+), F-MuLV (-)). This line temporarily produced infectious F-MuLV following 5 azacytidine treatment. These results suggest that the F-MuLV expression is specifically repressed in these cells by a mechanism which does not affect the F-MuLV related SFFV genome.
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology*; D002460:Cell Line; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005622:Friend murine leukemia virus / Q000187:drug effects / Q000235:genetics*; D005814:Genes, Viral / Q000187:drug effects; D007942:Leukemia, Experimental / Q000382:microbiology*; D051379:Mice
D001374:Azacitidine; D004121:Dimethyl Sulfoxide
Induction de virus de Friend infectieux après traitement par la 5 azacytidine d'une lignée d'érythroleucémie (HFL/b) non productrice de virus.