Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes.
A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11 beta-ol-3,20-dione and pregna-1,4-diene-11 beta-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions.
D000818:Animals; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D006908:Hydroxyprogesterones / Q000494:pharmacology*; D008297:Male; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology; D014529:Uridine / Q000378:metabolism
D005938:Glucocorticoids; D006908:Hydroxyprogesterones; C030228:11-hydroxyprogesterone; C038404:pregna-1,4-diene-11-ol-3,20-dione; D012313:RNA; D014529:Uridine