Demonstration of fibronectin in soft tissue tumours using the immunoperoxidase technique.
A variety of reactive, benign and malignant soft tissue lesions have been stained for fibronectin using the immunoperoxidase technique. Two patterns of mesenchymal staining have emerged. The first has a diffuse stromal collagen and basement membrane distribution within normal and neoplastic mesenchyme and the second a more specific intracytoplasmic granular staining pattern. The latter is seen only in lesions derived from fibrous-histiocytic and synovial cells, a finding which may be of diagnostic use. The possible significance of intracellular fibronectin in neoplastic mesenchyme is discussed.
D001485:Basement Membrane / Q000473:pathology; D005353:Fibronectins / Q000302:isolation & purification*; D005870:Giant Cell Tumors / Q000473:pathology; D006393:Hemangiopericytoma / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007890:Leiomyosarcoma / Q000473:pathology; D009363:Neoplasm Proteins / Q000302:isolation & purification*; D013584:Sarcoma, Synovial / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013194:Staining and Labeling; D013583:Synovial Membrane / Q000473:pathology
D005353:Fibronectins; D009363:Neoplasm Proteins