Morphological and immunological studies on pustulosis palmaris et plantaris, especially on its focal infection theory.
The deposition of immunoglobulins and complement was examined in skin lesions of pustulosis palmaris et plantaris by applying a direct-immunofluorescence technique. Linear deposition of IgG and C3 was demonstrated in the horny layer in 5 cases out of 10. The antikeratinlayer antibody was measured using the sera of patients with PPP, and elevated levels were recorded in patients with a maximum ratio of 1:80. Light and electron-microscopical examinations revealed a structure similar to the epidermal keratin layer of the tonsillar epidermis and phagocytosis of the structure by macrophages. This is an interesting finding in view of the antigen of the epidermal keratin layer.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005533:Foot Dermatoses / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D006229:Hand Dermatoses / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007633:Keratins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000473:pathology / Q000648:ultrastructure
D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G; D007633:Keratins