The effects of denervation and chronic haloperidol treatment on neostriatal dopamine receptor density are not additive in the rat.
The effects of combined denervation and chronic haloperidol treatment on neostriatal D-2 receptor density were examined, and a lack of additivity was found. In the first experiment, haloperidol treatment for 14 days initiated on day 4 after the unilateral intracerebral injection of 6-hydroxydopamine (6-OHDA) abolished the lesion-induced asymmetry of [3H]spiroperidol binding by elevating the density of sites in the intact striatum. These results were replicated in the second experiment, in which the drug treatment was begun 4-5 weeks after 6-OHDA. In both experiments the apomorphine-induced rotation did not differ significantly between lesioned rats treated with haloperidol or its vehicle.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002069:Butaclamol / Q000378:metabolism; D003342:Corpus Striatum / Q000032:analysis* / Q000378:metabolism; D004347:Drug Interactions; D006220:Haloperidol / Q000008:administration & dosage*; D006892:Hydroxydopamines / Q000008:administration & dosage*; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000032:analysis*; D012399:Rotation; D013134:Spiperone / Q000378:metabolism
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D013134:Spiperone; D016627:Oxidopamine; D002069:Butaclamol; D006220:Haloperidol; D001058:Apomorphine