title: Neuropeptides and gamma-aminobutyric acid in the vestibular nuclei of the rat: an immunohistochemical analysis. I. Distribution.
abstract: The distribution of substance P, Leu-enkephalin and gamma-aminobutyric acid (GABA) containing structures in the rat vestibular nuclei were investigated by means of an indirect immunofluorescent method using specific antisera to substance P, Leu-enkephalin and glutamic acid decarboxylase (GAD), respectively. Numerous positive neurons and fibers containing these three substances were found in the medial vestibular nucleus. Most of them were situated in the caudal part of the nucleus and those in the rostral part were concentrated dorsally. In the descending vestibular nucleus, a large number of substance P, Leu-enkephalin and GAD containing neurons were evenly distributed among longitudinally directing fiber bundles. A number of positive fibers with these substances were also observed. The lateral vestibular nucleus contained numerous coarse GAD-immunoreactive fibers surrounding Deiters' neurons, while substance P-immunoreactive and Leu-enkephalin-immunoreactive fibers were rather poorly distributed in this nucleus as well as in the superior vestibular nucleus.
mesh_terms: D000818:Animals; D004743:Enkephalin, Leucine / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D005968:Glutamate Decarboxylase / Q000032:analysis; D007106:Immune Sera; D008297:Male; D051381:Rats; D013373:Substance P / Q000032:analysis*; D014726:Vestibular Nuclei / Q000032:analysis / Q000166:cytology* / Q000201:enzymology; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
chemical_list: D007106:Immune Sera; D013373:Substance P; D005680:gamma-Aminobutyric Acid; D004743:Enkephalin, Leucine; D005968:Glutamate Decarboxylase