The exchange hypothesis for the formation of chromatid aberrations: an experimental test using bleomycin.
The association between bleomycin-induced chromatid aberrations and BUdR-label exchange between sister chromatids was investigated in order to evaluate Revell's exchange hypothesis for the formation of chromatid aberrations. The results of this study indicate that a larger than expected proportion of chromatid breaks can be accounted for by the exchange hypothesis though not all breaks are the result of incomplete exchange.
D001761:Bleomycin / Q000494:pharmacology*; D001973:Bromodeoxyuridine; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008954:Models, Biological; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001761:Bleomycin; D001973:Bromodeoxyuridine