Anaphylactoid reactions to neuromuscular blocking agents: a commonly undiagnosed condition?
A group of 28 patients with extreme, life-threatening sensitivity to suxamethonium was identified and 15 were studied in detail by skin-testing. The female/male ratio was 8/1. Sensitivity may be present without previous exposure to suxamethonium; in 3 patients reactions occurred during the first exposure to anaesthesia. Most patients showed one or more cross-sensitivities to alcuronium, tubocurarine, and gallamine. Signs of circulatory collapse were the sole presenting feature in 50% of the patients. Histamine release induced by the drug in vitro was demonstrated in some instances.
D000443:Alcuronium / Q000009:adverse effects; D000707:Anaphylaxis / Q000139:chemically induced*; D000768:Anesthesia, General / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D005703:Gallamine Triethiodide / Q000009:adverse effects; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects* / Q000494:pharmacology; D012882:Skin Tests; D013390:Succinylcholine / Q000009:adverse effects; D014403:Tubocurarine / Q000009:adverse effects
D009466:Neuromuscular Blocking Agents; D013390:Succinylcholine; D005703:Gallamine Triethiodide; D000443:Alcuronium; D014403:Tubocurarine