[Use of the leukomobilizing capacity of dextran sulfate for assessing the severity of an ionizing radiation lesion].
It was shown that the number of lymphocytes migrating to the blood 3 h after the administration of dextran sulphate (DS) is a function of the radiation dose absorbed (up to 1.5 Gy). It is supposed that 3 populations of lymphocytes varying in radiosensitivity are present in the blood. The authors suggest that it is possible to estimate the degree of the radiation damage according to the number of lymphocytes circulating in the blood under the effect of DS. It was also shown that the number of CFUc in the blood after the injection of DS is a function of the radiation dose absorbed.
D000818:Animals; D003114:Colony-Forming Units Assay; D016264:Dextran Sulfate; D003911:Dextrans; D004307:Dose-Response Relationship, Radiation; D007958:Leukocyte Count / Q000379:methods; D007962:Leukocytes / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000175:diagnosis*; D013997:Time Factors
D003911:Dextrans; D016264:Dextran Sulfate
Ispol'zovanie leĭkomobiliziruiushcheĭ sposobnosti dekstransul'fata dlia otsenki tiazhesti porazheniia ioniziruiushchim izlucheniem.