Disappearance of noradrenaline from different parts of the rabbit external ear following superior cervical ganglionectomy.
Following superior cervical ganglionectomy the noradrenaline tissue levels in the base of the rabbit external ear started to decrease after about 12 hours. About 4 hours later noradrenaline started to decrease about simultaneously in the middle piece and the tip. Within 24 hours after ganglionectomy the noradrenaline decreased rapidly in all three pieces. Thereafter the  noradrenaline of the base piece was levelling off at about 15% of the normal whereas the noradrenaline in the two other pieces remained at about 40% of the normal. The results indicate that the adrenergic innervation of the ear is complex, but that the base piece is supplied with adrenergic axons that are shorter than those of the middle and tip pieces. Based on 1: the delay of 4 hours observed in the pattern of the noradrenaline disappearance between the base and the two other pieces, and II: the difference in distance between the three pieces of the ear and the superior cervical ganglion, a transport rate of a "protecting factor" could be discussed to be about 1-2 cm/h. The rate of axonal transport of dopamine-beta-hydroxylase in the rabbit sciatic nerve, was found to be within the same range, being about 2 cm/h.
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000502:physiology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D004431:Ear, External / Q000294:innervation*; D005728:Ganglia, Sympathetic / Q000502:physiology*; D009410:Nerve Degeneration; D009638:Norepinephrine / Q000378:metabolism*; D011817:Rabbits; D012584:Sciatic Nerve / Q000502:physiology; D014661:Vasoconstriction
D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine