Midtrimester amniocentesis. An analysis of 923 cases with neonatal follow-up.
Maternal, fetal, and neonatal results and complications were analyzed after 923 genetic amniocenteses. Maternal age of 35 years and beyond was associated with a 2.0% risk of fetal trisomy 21 and a 3.0% risk of all major chromosome abnormalities. Comparable rates for women aged 40 and beyond were 4.8% and 7.2%. Neural tube defects were detected in 0.15% of procedures done for maternal age and 3.4% of those done for a previous involved child. The risk of spontaneous abortion as a result of amniocentesis was 0.2% to 1.4%. Mahogany or green fluid was associated with a 29% rate of fetal loss. Unexplained midtrimester elevations of maternal serum alpha-fetoprotein were associated with a 38% risk of a subsequent low-birth weight infant. The only neonatal complication associated with amniocentesis was an apparent marked increase in the incidence of lower-extremity orthopedic abnormalities.
D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D000653:Amniotic Fluid / Q000032:analysis; D001724:Birth Weight; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology; D007866:Leg / Q000002:abnormalities; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D018566:Pregnancy, High-Risk; D012120:Respiration Disorders / Q000209:etiology; D012306:Risk; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins