[Effect of sigetin treatment during reduced maternal-placental circulation in pregnant rabbits on the nucleic acid and total protein content of the organs of the progeny].
A study was made of the development of the progeny of rabbits (the whole body and individual organs) born to mothers with abnormal uteroplacental circulation (ligation of 40% of the preplacental vessels on the 18th day of pregnancy) treated with sigetin over the last trimester of pregnancy. Studies of the biochemical indicators (RNA, DNA, total protein in the brain and liver of sexually mature rabbit progeny) and physiological indicators (crude mass of the body, liver, brain and its parts) indicate that sigetin produces a therapeutic effect contributing to partial or complete compensation for the progeny underdevelopment because of mother's pathology.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001557:Benzenesulfonates / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009929:Organ Size; D010922:Placenta Diseases / Q000188:drug therapy* / Q000378:metabolism; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D011817:Rabbits
D001557:Benzenesulfonates; D009419:Nerve Tissue Proteins; D011506:Proteins; C001770:sigetin; D012313:RNA; D004247:DNA
Vliianie lecheniia sigetinom pri sokrashchennom matochno-platsentarnom krovotoke u krolikov vo vremia beremennosti na soderzhanie nukleinovykh kislot i obshchego belka v organakh u potomstva.