title: Augmentation of murine natural killer cell activity by manganese chloride.
abstract: Natural killer (NK) cell activity of spleen cells from male CBA/J mice was augmented by a single parenteral injection of MnCl2 administered 1 day prior to testing by in vitro and in vivo isotope release assays. Increased cytotoxic activity was observed in vitro against both NK-sensitive (YAC-1) and NK-resistant (EL-4) target cells. NK activity was also enhanced in normally low (A/J) and intermediately (C57Bl/6J) reactive strains of mice. Augmentation of NK activity by MnCl2 was accompanied by an increase in circulating interferon (IFN) levels.
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002712:Chlorides; D005260:Female; D007372:Interferons / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D017895:Manganese Compounds; D051379:Mice; D008815:Mice, Inbred Strains; D009532:Nickel / Q000633:toxicity
chemical_list: D002712:Chlorides; D017895:Manganese Compounds; D008345:Manganese; C022838:nickel chloride; D009532:Nickel; D007372:Interferons; C025340:manganese chloride