title: Studies of the effect of experimental inflammation on rat liver nucleotide sugar pools.
abstract: The effect of experimental inflammation on levels of nucleotide sugars was studied in rat liver. There was an increase of about 2-fold in the levels of UDP-N-acetylhexosamines and GDP-Man at 8 and 4 hr after inflammation, respectively. At 48 hr after inflammation GDP-Man had returned close to control values, but UDP-N-acetylhexosamines were still about 50% above controls. There was a 30% reduction in CMP-NeuAc and UDP-Gal at 8-12 hr after inflammation before increasing to slightly above controls at 16-48 hr after inflammation. Inflammation resulted in an increase in activities of glucosamine-6-phosphate synthase and UDP-GlcNAc-2'-epimerase to about twice control activities at 24 and 8 hr after inflammation, respectively, before declining; CMP-NeuAc synthase activities did not show large changes following inflammation.
mesh_terms: D000116:Acetylgalactosamine / Q000378:metabolism; D000117:Acetylglucosamine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003569:Cytidine Monophosphate N-Acetylneuraminic Acid / Q000378:metabolism; D006155:Guanosine Diphosphate Mannose / Q000378:metabolism; D066298:In Vitro Techniques; D007249:Inflammation / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008358:Mannose / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism*; D051381:Rats; D014536:Uridine Diphosphate N-Acetylgalactosamine / Q000378:metabolism; D014537:Uridine Diphosphate N-Acetylglucosamine / Q000378:metabolism
chemical_list: D000596:Amino Acids; D009711:Nucleotides; D003569:Cytidine Monophosphate N-Acetylneuraminic Acid; D006155:Guanosine Diphosphate Mannose; D014537:Uridine Diphosphate N-Acetylglucosamine; D014536:Uridine Diphosphate N-Acetylgalactosamine; D000116:Acetylgalactosamine; D008358:Mannose; D000117:Acetylglucosamine