[Change in the histochemical and morphometric indices of the mouse mammary gland during administration of various doses of vitamin A].
Experiments were made to study some indicators of the metabolism in the body and non-lactation mammary gland under administration of different doses of retinol acetate. Particular attention was paid to the animals' body and mammary gland weight, to the measurement of RNA and total protein in the epithelial cells, nuclear and cytoplasmic areas in the epitheliocytes. Administration to experimental animals of vitamin A in a dose of 30 000 IU, that does not provoke toxic hypervitaminosis, simulates vital activity of the cells, manifesting in the increased area of the nuclei and cytoplasm, in the enlargement of the total cytoplasm protein and of the content of nuclear RNA and cytoplasm, in the increased weight of the mammary gland and body weight. Administration of vitamin A in a dose of 80 000 IU leading to the occurrence of toxic hypervitaminosis symptoms reduces vital activity of the cells of mouse non-lactation mammary gland which manifests in the reduction of the body and mammary gland weight, of the area of the nuclei and cytoplasm of the epitheliocytes, fall of the total cytoplasm protein and RNA of the nucleus and cytoplasm.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004224:Diterpenes; D005260:Female; D008321:Mammary Glands, Animal / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D000084562:Retinyl Esters; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity
D004224:Diterpenes; D011506:Proteins; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D012313:RNA
Izmenenie gistokhimicheskikh i morfometricheskikh pokazateleĭ v molochnoĭ zheleza mysheĭ pri vvedenii razlichnykh doz vitamina A.