Type I and III collagens as a possible target for drug delivery to the injured sites of vascular bed.
Interaction of anti-human collagen types I and III antibodies, as well as human red blood cells conjugated with these antibodies, with the surface of denuded intima of human aorta has been studied. Data on the accessibility of antigenic determinants of collagen types I and III for antibodies and red blood cells conjugated with these antibodies have been obtained in ex vivo experiments in an original model. On the basis of the obtained results it is concluded that antigenic determinants of collagen types I and III exposed as a result of blood vessel wall injury can serve as a target for drug delivery to the injured site(s).
D000918:Antibody Specificity; D001808:Blood Vessels / Q000293:injuries; D003094:Collagen / Q000008:administration & dosage / Q000276:immunology*; D004727:Endothelium / Q000502:physiology; D000939:Epitopes; D006801:Humans
D000939:Epitopes; D003094:Collagen