A striatal serotonergic involvement in the behavioural effects of anticholinesterase organophosphates.
Acute administration of the anticholinesterase agents diisopropylfluorophosphate, soman, sarin and tabun to rats in sub-convulsive doses produced tremors and hind-limb abduction. The ratios of the levels of 5-HIAA to 5-HT in the striatum showed a consistent tendency to be increased, suggesting an increase in 5-HT turnover. Both the behavioural and the biochemical changes were antagonized by atropine. The possible involvement of a cholinergic-serotonergic interaction in these tremors and hind-limb abduction is discussed.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003342:Corpus Striatum / Q000502:physiology*; D004347:Drug Interactions; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D009943:Organophosphorus Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D014202:Tremor / Q000139:chemically induced
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009943:Organophosphorus Compounds; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D001285:Atropine