Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels.
The effect of indomethacin 1% drops against a placebo (NaCl 0.9% solution) was tested in rabbits' corneas injured by a standardized chemical burn. The corneas treated with indomethacin 1% had less neovascularisation and a much smaller increase in the PGE2 levels as compared with the control fellow eyes treated with a placebo. It appears that indomethacin 1% drops have a clear effect on the inflammatory response of the cornea and deserve a clinical trial in selected patients suffering from corneal inflammatory changes.
D000287:Administration, Topical; D000818:Animals; D003315:Cornea / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D015232:Dinoprostone; D007213:Indomethacin / Q000008:administration & dosage*; D007634:Keratitis / Q000188:drug therapy*; D009389:Neovascularization, Pathologic; D011458:Prostaglandins E / Q000378:metabolism*; D011817:Rabbits
D011458:Prostaglandins E; D015232:Dinoprostone; D007213:Indomethacin