title: Comparison of biological properties of A(H1N1) influenza virus strains isolated in 1947 and during the epidemic of 1977.
abstract: A comparative analysis of biological properties of A(H1N1) influenza virus strains isolated in 1977 and the prototypic strain isolated in 1947 was performed. The strains showed marked differences in the vivo and in vitro replication as well as in the sensitivity to inhibitors of normal animal sera and to interferon. Also, their neuraminidases displayed different sensitivity to detergents. On the other hand, the strains did not differ significantly with respect to ability for interferon induction in vivo and hemagglutinin sensitivity to detergents.
mesh_terms: D004196:Disease Outbreaks; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000201:enzymology / Q000502:physiology*; D007372:Interferons / Q000494:pharmacology; D009439:Neuraminidase / Q000378:metabolism; D013045:Species Specificity; D014779:Virus Replication / Q000187:drug effects
chemical_list: D007372:Interferons; D009439:Neuraminidase