Aneuploidy induced by bleomycin in oocytes of Drosophila melanogaster: studies with the aneuploidy pattern method.
The induction of aneuploidy (numerical chromosome aberrations) in oocytes of Drosophila melanogaster by the antitumor drug bleomycin (BLM) was studied with the "aneuploidy pattern method." The aneuploidy pattern obtained after feeding BLM at a concentration of 50 micrograms/ml to Drosophila females resembles the pattern obtained after X-irradiation (3,000 R). This emphasizes the radiomimetic nature of BLM. In addition, new control material is presented. The new control pattern agrees well with that obtained earlier.
D000782:Aneuploidy; D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D005260:Female; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D009865:Oocytes / Q000187:drug effects; D014965:X-Rays
D001761:Bleomycin