A new method of skin graft adhesion.
An industrially produced fibrinogen-Aprotinin and thrombin-calcium chloride 'tissue glue', Tisseel, has been tested for skin grafting. The 'take' of the graft was successful in 92% after grafting with Tisseel, and in 83% without gluing. In difficult areas, such as over mobile muscle or close to skin folds, 88% of cases were successful with tissue gluing and 44% without.
D000293:Adolescent; D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000627:therapeutic use*; D002122:Calcium Chloride / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D012878:Skin Neoplasms / Q000601:surgery; D016038:Skin Transplantation; D013524:Surgical Flaps; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin; D002122:Calcium Chloride