Initial studies of hypoxic radioprotection by deoxygenated dextran-hemoglobin.
Initial studies were performed to examine the potential of perfused dextran-hemoglobin to protect pig skin or mouse bone marrow cells against radiation damage. Some protection was indicated in both systems. In the pig skin a protection factor of 1.5 was observed for moist desquamation, and 2.0 for necrosis. These results suggest the possibility of using blood substitutes to induce tissue hypoxia for therapeutic purposes.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects*; D003114:Colony-Forming Units Assay; D003911:Dextrans / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006454:Hemoglobins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009336:Necrosis; D010100:Oxygen / Q000502:physiology; D010477:Perfusion; D011833:Radiation Injuries, Experimental / Q000473:pathology / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D013552:Swine
D003911:Dextrans; D006454:Hemoglobins; D011837:Radiation-Protective Agents; C040953:dextran-hemoglobin complex (deoxygenated); D010100:Oxygen