title: Blood leukocyte responses to extracorporal circulation. III. Long term extracorporeal circulation without and with irradiation in normal and splenectomized dogs.
abstract: Long term (12-48 h) extracorporeal circulation without and with irradiation of the blood was performed in normal and splenectomized dogs in order to observe the effect of these procedures on blood leukocyte counts including CFU-C. A transient granulocytopenia and a decrease of lymphocyte count were observed. The blood CFU-C level diminished to a very low level and remained low for the whole time of the experiments. There was no significant difference between the results of procedures with or without irradiation. The similar effect of a shortened tubing system on the blood leukocyte count is also reported. Heparin infusion alone did not decrease the peripheral CFU-C concentration. The possible explanations for the observed phenomena are discussed.
mesh_terms: D000818:Animals; D001769:Blood / Q000528:radiation effects*; D003114:Colony-Forming Units Assay; D004285:Dogs; D004906:Erythrocyte Count; D005112:Extracorporeal Circulation; D006493:Heparin / Q000494:pharmacology; D007263:Infusions, Parenteral; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology*; D008297:Male; D013154:Spleen / Q000502:physiology; D013156:Splenectomy; D013326:Strontium Radioisotopes; D013997:Time Factors
chemical_list: D013326:Strontium Radioisotopes; D006493:Heparin