Action of substance P and an SP-hexapeptide analogue on avoidance learning in rats.
The effects of Substance P (SP) (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) and of a SP hexapeptide analogue (SP-A) (Lys-Phe-Ile-Gly-Leu-MetNH2) on active avoidance learning were investigated in spontaneously hypertensive rats (SHR) and Wistar rats. Active avoidance learning was slower in SHR than in Wistar rats. SP-A "normalized" the slower active avoidance learning in SHR, whereas SP did not. Some possible causes of this difference as well as the mechanism of the normalizing effect of SP-A are discussed.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D006973:Hypertension / Q000523:psychology; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*
D009842:Oligopeptides; C027109:lysyl-phenylalanyl-isoleucyl-glycyl-leucyl-methioninamide; D013373:Substance P