[Symptomatic scleroderma caused by bleomycin].
Side effects of bleomycin therapy are most frequent in the skin and as pulmonary fibrosis because of the nearly selective concentration in these organs. The cutaneous manifestations include a variety of clinical symptoms, most frequently erythema and infiltrations with marked hyperpigmentation. A 38-year-old patient is reported who received 615 mg bleomycin for therapy of a malignant testicular teratoma and in the following time developed numerous morphoea-like lesions, acrocyanosis, Raynaud's phenomenon, acrosclerosis, and cutaneous calcinosis. Histologically, the alterations were similar to those of scleroderma. In contrast to progressive systemic sclerosis the symptomatic character of the lesions is evident, for the skin changes resolved several months after the drug was discontinued.
D000328:Adult; D001761:Bleomycin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000473:pathology
D001761:Bleomycin
Symptomatische Sklerodermie durch Bleomyzin.