Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat.
The descending substance P projections from the ventral medulla were studied in the rat. Electrolytic lesions which included the nucleus interfascicularis hypoglossi decreased the substance P-like immunoreactivity (SP-I) in both the intermediolateral cell column and the ventral horn of the spinal cord. Lesions of other ventral medullary areas and midbrain hemisections did not change spinal cord SP-I levels. Intracerebroventricular administration of the serotonin neurotoxin, 5,7-dihydroxytryptamine, reduced the SP-I content of the ventral horn but not of the intermediolateral cell column.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D005260:Female; D008526:Medulla Oblongata / Q000033:anatomy & histology* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011903:Raphe Nuclei / Q000033:anatomy & histology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000032:analysis* / Q000502:physiology; D013373:Substance P / Q000032:analysis*
D015116:5,7-Dihydroxytryptamine; D013373:Substance P