The reticuloendothelial system in scrapie pathogenesis.
A single injection of 1 mg dextran sulphate 500 per mouse considerably prolonged incubation times and produced survivors, even when given 3 days after intravenous or intraperitoneal scrapie infection. Since this compound could be detected in mononuclear phagocytes of spleen and lymph nodes for up to 7 months, it is suggested that it impairs a particular step in the infectious process in these cells of the lymphoreticular system. Blockage of the reticuloendothelial system by trypan blue and silica did not alter the pathogenesis.
D000818:Animals; D016264:Dextran Sulfate; D003911:Dextrans / Q000627:therapeutic use; D008198:Lymph Nodes / Q000473:pathology*; D008214:Lymphocytes / Q000166:cytology; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000473:pathology*; D012608:Scrapie / Q000188:drug therapy / Q000473:pathology*; D012756:Sheep; D013154:Spleen / Q000473:pathology*
D003911:Dextrans; D016264:Dextran Sulfate