Comparison between commercial heparin, low molecular weight heparin and pentosan polysulfate on hemostasis and platelets in vivo.
The effect of commercial heparin (MW 15000; 60 U/kg), low molecular weight heparin (MW 4500, 60 U/kg), sodium pentosan polysulfate (PZ-68) in doses of 0.5, 1, 2 and 5 mg/kg and 1 mg/kg combined with dextran 70 (0.5 g/kg) on microvascular hemostasis and platelet activity in vivo was investigated in the microcirculation of rabbit mesentery and ear chamber, respectively. Low molecular weight heparin did not alter the hemostasis: nonetheless, commercial heparin and PZ-68 interfered with the hemostatic mechanism by decreasing the stability of the hemostatic plug. This abnormality was more apparent in the venular than in the arteriolar system. Both heparins exhibited a trend towards an increase in platelet reactivity and the reverse was observed following the administration of PZ-68.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D008643:Mesentery / Q000098:blood supply; D008833:Microcirculation; D008970:Molecular Weight; D010426:Pentosan Sulfuric Polyester / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011134:Polysaccharides / Q000494:pharmacology*; D011817:Rabbits
D011134:Polysaccharides; D010426:Pentosan Sulfuric Polyester; D006493:Heparin