title: Squamous cell carcinoma of the thoracic esophagus.
abstract: Carcinoma of the esophagus, the fourth most common malignant tumor of the gastrointestinal tract, still has a dismal outlook. Since July 1960, we have collected data on 642 patients with this lesion. Adenocarcinomas (which might arise from gastric mucosa) have been excluded. Almost one-fifth of the patients were far-advanced and inoperable when first diagnosed. Time between onset of symptoms and diagnosis was deemed excessive in over half of the patients; physicians frequently accounted for much of this delay. Preoperative diagnosis proved accurate in 99 per cent of the cases. Evaluations of direct extensions and distant metastases and attention to nutritional status correction were of prime importance. Operative technique and indications for surgery have become "standardized," and while surgical mortality has remained about 20 per cent throughout the period, morbidity has decreased steadily. Comparisons of irradiation and surgery in relation to palliation indicate that palliation is probably better in the surgically treated patient. However, it is emphasized that this comparison, as well as comparison of other results, is not scientifically valid since the groups of patients are not comparable due to clinical selection.
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D010166:Palliative Care; D011182:Postoperative Care; D011379:Prognosis; D013997:Time Factors