title: [Chemotherapy of nonseminomatous testicular tumors. The results of a pilot study with reduced cis-platin dosage].
abstract: 23 patients with non-seminomatous germ cell tumors of the testis were treated with Cis-Platinum 50 mg/m2 body surface on day 1, Vinblastine 0,4 mg/kg body weight in two doses on days 1 and 2, and Bleomycin 30 mg daily as continuous infusion (days 2-5). 7 patients were treated adjuvant after retroperitoneal lymphadenectomy. One of these had a relapse, he again received the same therapy and now has a complete remission. All other adjuvant treated patients are free of tumor. Of the 16 patients with large retroperitoneal and/or lung metastases, 10 (62%) had a complete remission, 2 of them after resection of persistent metastases after chemotherapy. 4 of the 10 patients with complete remission relapsed. In two patients with relapse a new complete remission could be established by the same chemotherapy. The remission rates achieved with this therapy with a relatively low dose of Cis-Platinum are similar to those obtained with higher doses of this agent. It is possible that there are more relapses, but these respond well to further treatment. Thus, the survival times of the patients treated with this protocol are similar to those reported in the literature. It is concluded that this regimen is an effective treatment in non seminomatous germ cell tumors.
mesh_terms: D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000401:mortality; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D003520:Cyclophosphamide; D002945:Cisplatin; D007069:Ifosfamide
vernacular_title: Chemotherapie nicht-seminomatöser Hodentumoren. Ergebnisse einer Pilot-Studie mit reduzierter Cis-Platin-Dosis.