Immunohistochemical demonstration of multiple neurohormonal polypeptides in a case of pure testicular carcinoid.
A primary pure testicular carcinoid from a 48-year-old man was examined with antisera raised against various neurohormonal polypeptides. Histochemically, both argyrophil and argentaffin reactions were positive. The immunohistochemical finding of immunoreactive cells for 5-hydroxytryptamine (5-HT) (serotonin), substance P, and vasoactive intestinal polypeptide (VIP) demonstrated the multihormonal nature of this tumor.
D002276:Carcinoid Tumor / Q000032:analysis*; D005768:Gastrointestinal Hormones / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000032:analysis*; D013373:Substance P / Q000032:analysis*; D013736:Testicular Neoplasms / Q000032:analysis*; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
D005768:Gastrointestinal Hormones; D012701:Serotonin; D013373:Substance P; D014660:Vasoactive Intestinal Peptide