Anti-IgE-and ConA-induced histamine release from human basophilic leukocytes: the existence of differences in relative responses within individuals.
Histamine release was induced from human blood leukocytes with Concanavalin A (ConA) and two different preparations of anti-IgE. A dose-response curve was constructed for each cell population and secretagogue. No qualitative difference in response pattern was observed with the two anti-IgEs; however, the relative release-inducing efficacy of ConA and anti-IgE seemed to vary with the individual providing the cells. These findings indicate that release induced by ConA is not completely equivalent to that induced by anti-IgE.
D000888:Antibodies, Anti-Idiotypic / Q000502:physiology*; D001491:Basophils / Q000378:metabolism*; D003208:Concanavalin A / Q000494:pharmacology*; D004306:Dose-Response Relationship, Immunologic; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology* / Q000502:physiology
D000888:Antibodies, Anti-Idiotypic; C026408:anti-IgE antibodies; D003208:Concanavalin A; D007073:Immunoglobulin E