Characterization of the Abelson murine leukemia virus-encoded tyrosine-specific protein kinase.
There is sufficient evidence that the A-MuL V protein is a tyrosine-specific protein kinase. There are methods for detecting this kinase activity and this kinase has been expressed in E. coli. Because the information coding for the tyrosine-specific protein kinase is present in normal mouse cells, such an enzyme must have a normal physiologic function. The elucidation of this physiologic function and the understanding of the role of this enzyme activity in neoplastic transformation is the challenge of the future.
D000011:Abelson murine leukemia virus / Q000201:enzymology*; D000818:Animals; D009052:Leukemia Virus, Murine / Q000201:enzymology*; D051379:Mice; D008970:Molecular Weight; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation; D019000:Phosphotyrosine; D011494:Protein Kinases / Q000302:isolation & purification / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases; D011865:Radioisotope Dilution Technique; D014443:Tyrosine / Q000031:analogs & derivatives / Q000032:analysis
D010761:Phosphorus Radioisotopes; D019000:Phosphotyrosine; D014443:Tyrosine; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases