title: [4,4'-D-diaminopropionic acid]gramicidin S: a synthetic gramicidin S analog with antimicrobial activity against Gram-negative bacteria.
abstract: Gramicidin S is especially active against Gram-positive bacteria; e.g., Staphylococcus aureus. An analog, [4,4'-D-diaminopropionic acid]gramicidin S, which contains D-diaminopropionic acid residues instead of D-phenylalanine residues, has been synthesized. This analog is active against some of the Gram-negative bacteria; e.g., Escherichia coli and Salmonella typhosa. Activities of several related analogs are discussed.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002942:Circular Dichroism; D006096:Gramicidin / Q000138:chemical synthesis / Q000633:toxicity* / Q000031:analogs & derivatives; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
chemical_list: D007202:Indicators and Reagents; D006096:Gramicidin; C039050:(4,4'-diaminopropionic acid)gramicidin S