Selected immunological reactions to measles virus in immunosuppressed guinea pigs.
Cyclophosphamide and hydrocortisone treatment of measles virus infected guinea pigs resulted in suppression of cele- and antibody mediated immune reactions although a high dose of measles virus (10(5.5) TCID50) was used for infection: MIT was delayed and depressed; HI serum antibody response was almost completely inhibited.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002464:Cell Migration Inhibition; D003520:Cyclophosphamide / Q000494:pharmacology; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D006854:Hydrocortisone / Q000494:pharmacology; D007109:Immunity / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007962:Leukocytes / Q000276:immunology; D008457:Measles / Q000276:immunology*; D008459:Measles virus / Q000276:immunology
D000914:Antibodies, Viral; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D006854:Hydrocortisone