title: [Chemotherapy and immunotherapy of intracranial malignant gliomas].
abstract: Although in recent years a great attempt has been made in brain tumor chemotherapy, this therapeutic approach appears to be conditioned by a large number of problems such as cell kinetics, tumor growth modalities, and drug delivery. Therefore only a small number of drugs (BCNU, CCNU, streptozotocin, and procarbazine) clearly demonstrate effectiveness against these tumors. Immunotherapy raises the same and other problems. In fact, if immune reaction is quite possible inside the brain, unfortunately current immunostimulant methods are unable to produce significant improvements.
mesh_terms: D001500:BCG Vaccine / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy*; D003131:Combined Modality Therapy; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007372:Interferons / Q000627:therapeutic use; D014020:Tissue Extracts / Q000627:therapeutic use
chemical_list: D001500:BCG Vaccine; D014020:Tissue Extracts; D007372:Interferons
vernacular_title: Chemioterapia ed immunoterapia dei gliomi maligni endocranici.