Production of auto-anti-idiotypic antibody during the normal immune response. IX. Characteristics of the auto-anti-idiotype antibody and its production.
Using hapten-reversible inhibition of plaque formation as an assay for auto-anti-idiotype antibody (anti-Id) and as a means for following idiotype (Id) expression, we have obtained evidence that following immunization with trinitrophenyl (TNP) conjugates (a) there are differences in Id expression in the anti-TNP antibody response to different TNP conjugates although there is some overlap; (b) different strains, although showing some differences in Id expression, tend to produce cross-reactive Ids, thus no obvious allotype linked inheritance of Id expression is observed in this heterogeneous immune response; (c) the auto-anti-Id produced following immunization with TNP-Brucella abortus or TNP-Ficoll tends to be of the IgG2a and IgG2b isotypes.
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000276:immunology*; D002417:Cattle / Q000276:immunology; D006241:Haptens; D006462:Hemolytic Plaque Technique; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014301:Trinitrobenzenes / Q000276:immunology; D005719:gamma-Globulins
D001323:Autoantibodies; D006241:Haptens; D007130:Immunoglobulin Idiotypes; D014301:Trinitrobenzenes; D005719:gamma-Globulins