title: 2'-5' oligo(A) synthetase levels in interferon-sensitive or -resistant lymphoid cells.
abstract: The activity of 2'-5' oligo(A) synthetase has been measured both in control and interferon-treated lymphoid cells. While control or interferon-treated Raji and Namalwa cells exhibit low activity of the 2'-5' oligo(A) synthetase, the activity of this enzyme is increased 20-fold when Daudi cells are treated with the same dose of human interferon. The same enzyme is induced by interferon in R3HR-1 cells to a lesser extent.
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000032:analysis*; D002478:Cells, Cultured; D004351:Drug Resistance; D004790:Enzyme Induction; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology*
chemical_list: D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase