Tachykinin-like central activity of neuromedin K in mice.
Neuromedin K, a decapeptide isolated from porcine spinal cord and suggested to have tachykinin-like activity in vitro, produced reciprocal hind-limb scratching when injected intrathecally to mice. Neuromedin K was 20-60 times less potent in producing scratching (on a molar basis) than substance P, kassinin, eledoisin or physalaemin. The activity of neuromedin K was blocked by the substance P antagonist [D-Pro2D-Trp7.9]substance P at doses of antagonist which effectively blocked the activity of the other tachykinins. These data provide the first evidence for tachykinin-like activity of neuromedin K in the central nervous system.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004600:Eledoisin / Q000494:pharmacology; D015286:Kassinin; D008297:Male; D051379:Mice; D015287:Neurokinin B; D009842:Oligopeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010455:Peptides / Q000502:physiology*; D010803:Physalaemin / Q000494:pharmacology; D013373:Substance P / Q000494:pharmacology; D015320:Tachykinins
D009842:Oligopeptides; D010455:Peptides; D015320:Tachykinins; D010803:Physalaemin; D013373:Substance P; D015286:Kassinin; D004600:Eledoisin; D015287:Neurokinin B