title: The passive transfer of severe allergic neuritis in Lewis rats with lymphoid cells preincubated with P2 protein.
abstract: The passive transfer of both clinical signs and histologic lesions characteristic of allergic neuritis was successfully performed in Lewis rats using pooled spleen and lymph node cells, or T lymphocytes therefrom, if first preincubated in petri dishes with P2 protein for 72 hr. For passive transfer, cells were taken from donors 8-16 days after sensitization with P2 protein or myelin in Freund's complete adjuvant, and administered via the tail vein; clinical signs appeared 12-13 days later. This study supports the importance of cell-mediated immunity in EAN and the antigenic role of the P2 protein.
mesh_terms: D000818:Animals; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D004676:Myelin Basic Protein / Q000008:administration & dosage* / Q000276:immunology; D018996:Myelin P2 Protein; D009444:Neuritis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D004676:Myelin Basic Protein; D018996:Myelin P2 Protein