title: Zinc and cadmium concentration in prostatic carcinoma of different histological grading in comparison to normal prostate tissue and adenofibromyomatosis (BPH).
abstract: Zn and Cd concentrations in tissue of normal prostate gland, BPH and prostatic carcinoma of different histological grades have been determined by atomic absorption spectrometry before therapy. We found a distinct biological antagonistic effect between Zn and Cd in the human prostate gland. We have seen an increasing amount of Zn in BPH, but a decrease in prostatic cancer. In contrast, we found a continuous increase of cadmium concentration from the normal prostate via BPH through carcinoma.
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002104:Cadmium / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism; D002648:Child; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism*
chemical_list: D002104:Cadmium; D015032:Zinc