title: Alpha 1-antitrypsin, alpha 1-antichymotrypsin and alpha 2-macroglobulin in human liver fluke (opisthorchiasis).
abstract: In mild and moderate Opisthorchis viverrini infection it is difficult to find clinical signs for diagnosis. Also routine clinical chemical reactions often fail to demonstrate changes in these patients. This study showed a significant increase of serum proteinase inhibitors, alpha 2-macroglobulin, alpha 1-antitrypsin and alpha 1-antichymotrypsin in patients suffering from O. viverrini infection compared with healthy controls. The increase of proteinase inhibitors together with other biochemical liver function tests may be useful as an indication of the impairment of liver function and the host response in Opisthorchiasis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008875:Middle Aged; D009889:Opisthorchiasis / Q000175:diagnosis*; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism*
chemical_list: D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D002918:Chymotrypsin