Serum acute-phase glycoproteins and immune complexes in relation to smoking and respiratory symptoms: an epidemiological study.
A nephelometric assay of concanavalin A binding was used to measure serum acute-phase glycoproteins in young conscripts, in middle-aged males, and in adults with persistent respiratory symptoms. The findings in conscripts, irrespective of the smoking status, did not differ from those in blood donors, whereas, a strikingly higher portion (38%) of the middle-aged heavy smokers exhibited elevated values. In subjects with persistent respiratory symptoms the corresponding figure was even higher (52%), but no difference was recorded between smokers and non-smokers. Elevated amounts of circulating immune complexes, as measured by conglutinin-binding assay, were detected in 6% of the middle-aged males and in 20% of the subjects with persistent respiratory symptoms.
D000209:Acute-Phase Proteins; D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis*; D037222:Collectins; D004797:Enzyme-Linked Immunosorbent Assay; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D012140:Respiratory Tract Diseases / Q000276:immunology*; D012712:Serum Globulins / Q000276:immunology; D012907:Smoking
D000209:Acute-Phase Proteins; D000936:Antigen-Antibody Complex; D001798:Blood Proteins; D037222:Collectins; D006023:Glycoproteins; D012712:Serum Globulins; C024014:conglutinin