Metabolic profiles of prostate gland after the administration of prolactin and bromocriptine.
Wistar strain male albino rats were treated with prolactin (PRL) and bromocriptine to induce hyper- and hypoprolactinemia respectively and prostatic metabolic profiles were analysed. The energy metabolism of prostate was activated by PRL and inhibited by bromocriptine. The androgen-dependent metabolic phases of ventral prostate such as glycogenolysis, glycolysis, hexose monophosphate shunt were activated in the presence of PRL and inhibited in the presence of bromocriptine. The activities of markers of monosaccharide formation were elevated by PRL and inhibited by bromocriptine. The amino-acid oxidations and transaminations were accelerated by PRL and suppressed by bromocriptine. Hence, PRL-mediated activation of seminal plasma in the ventral prostate is suggested.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004734:Energy Metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D008297:Male; D011388:Prolactin / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D001971:Bromocriptine; D011388:Prolactin; D006003:Glycogen