Group-specific component (Gc) subtypes and schizophrenia.
Two hundred and fifteen schizophrenic patients (108 males and 107 females) in north-east England have been investigated for Gc types and subtypes and compared with the frequencies in first-degree relatives and controls. Böök et al. (1978) described Gc2 allele association with schizophrenia. No such association was found with the Gc2 allele in the present study although there is a tendency towards an increased frequency in females. In subtype allele frequencies the female patients showed a significant reduction of Gc1S allele. The results suggest a difference in susceptibility associated with the Gc locus in patients of different sexes.
D000483:Alleles; D000510:Alpha-Globulins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D012737:Sex Factors; D014809:Vitamin D-Binding Protein
D000510:Alpha-Globulins; D002352:Carrier Proteins; D014809:Vitamin D-Binding Protein