Immunogenicity of fatty acid anilides in rabbits and the pathogenesis of the Spanish toxic oil syndrome.
Fatty acid anilides, the major xenobiotic found in the cooking oils responsible for the Spanish toxic oil syndrome, are immunogenic for rabbits as ascertained by a skin test reaction, the characterization of specific antibodies against anilides and the immunofluorescent detection of 'anilide dependent antigens' in tissue slices from treated animals.
D000813:Anilides / Q000276:immunology* / Q000633:toxicity; D000818:Animals; D000906:Antibodies / Q000032:analysis; D001921:Brain / Q000276:immunology; D001937:Brassica; D004342:Drug Hypersensitivity / Q000209:etiology*; D000939:Epitopes / Q000032:analysis; D005229:Fatty Acids, Monounsaturated; D005455:Fluorescent Antibody Technique; D005506:Food Contamination; D007114:Immunization; D007163:Immunosorbent Techniques; D008041:Linoleic Acids / Q000276:immunology* / Q000633:toxicity; D008081:Liposomes / Q000008:administration & dosage; D009132:Muscles / Q000276:immunology; D009468:Neuromuscular Diseases / Q000209:etiology*; D009821:Oils / Q000506:poisoning*; D009829:Oleic Acids / Q000276:immunology* / Q000633:toxicity; D010938:Plant Oils; D011817:Rabbits; D000074262:Rapeseed Oil; D012882:Skin Tests; D013577:Syndrome
D000813:Anilides; D000906:Antibodies; D000939:Epitopes; D005229:Fatty Acids, Monounsaturated; D008041:Linoleic Acids; D008081:Liposomes; D009821:Oils; D009829:Oleic Acids; D010938:Plant Oils; D000074262:Rapeseed Oil; C039294:linoleylanilide; C038731:oleoylanilide