Antigen-induced histamine-release in diagnosis of allergy.
Antigen-induced histamine-release from basophils was evaluated in 12 patients with hypersensitivity to grass, 14 patients with hypersensitivity to grains and 14 patients with hypersensitivity to insect-venom using a test with very high sensitivity. - Histamine-release upon stimulation with antigen was found in all patients with grass-hypersensitivity, in 12 of 14 patients with grain-hypersensitivity and in 10 of 14 patients with insect-venom-hypersensitivity. Additionally performed determination of total-IgE proved less valuable, whereas specific-IgE and skin-test showed a higher validity in hypersensitivity to grains.
D000941:Antigens / Q000276:immunology*; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000276:immunology*; D011058:Pollen; D011863:Radioimmunoassay; D014688:Venoms / Q000276:immunology
D000941:Antigens; D014688:Venoms