title: Experimental high-velocity missile head injury.
abstract: A standardized experimental high-velocity penetrating head-injury model has been produced in which pathological lesions were observed, not only in the wound track but at sites more remote from the track in the hypothalamus, brain stem and cerebellum. Diffuse subarachnoid haemorrhage was common and intraventricular haemorrhage was a constant feature. Other constant histological abnormalities were:L 1. Perivascular "ring' haemorrhages. 2. Perivascular haemorrhage with a surrounding zone of decreased staining intensity. 3. Perivascular increased staining intensity. 4. Areas of decreased staining intensity apparently dissociated from areas of haemorrhage. The pathogenesis of the perivascular lesions is discussed and preliminary studies suggest that these may be the site of early oedema. The implications of this experiment for military surgery and for ballistic protection of the head are discussed.
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000473:pathology; D007031:Hypothalamus / Q000473:pathology; D008253:Macaca mulatta; D013194:Staining and Labeling; D014948:Wounds, Gunshot / Q000473:pathology*