Slow excitatory transmission in rat dorsal horn: possible mediation by peptides.
Repetitive stimulation of a dorsal root elicited a slow depolarization in about half of the dorsal horn neurons examined in the rat spinal cord slice preparation. The response was markedly depressed or abolished in the presence of substance P, substance P antagonists and capsaicin. In some dorsal horn neurons a slow hyperpolarization was also observed.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology*; D004553:Electric Conductivity; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D013779:Tetrodotoxin; D002766:Cholecystokinin; D002211:Capsaicin