The cellular oncogenes c-myc, c-myb and c-erb are transcribed in defined types of avian hematopoietic cells.
The possible role of normal chicken cellular sequences c-erb, c-myb and c-myc, together referred to as c-onc genes and related to the oncogenes of defective avian acute leukemia retroviruses (DLVs), was investigated by determining the accumulation of c-onc RNA in different avian cells an cell lines. Levels of c-myc and in some instances c-myb RNA are elevated in immature hematopoietic cells or cell lines from various lineages but more mature hematopoietic cells, as well as non-hematopoietic cells, contain only low levels. In contrast, the level of c-erb RNA is generally low, but high in a small number of normal bone marrow cells. The results indicate that the cellular homologues of the viral oncogenes are differentially expressed during hematopoiesis. They also indicate that the hypothesis that DLV target cells express their homologous c-onc genes might hold for c-erb, but is not valid in its simple form for c-myc and c-myb.
D000818:Animals; D001354:Avian Leukosis Virus / Q000502:physiology; D001717:Birds / Q000097:blood / Q000235:genetics*; D001854:Bone Marrow Cells; D002472:Cell Transformation, Viral; D002645:Chickens; D003370:Coturnix; D003673:Defective Viruses / Q000502:physiology; D004900:Erythroblasts / Q000378:metabolism; D005786:Gene Expression Regulation; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009857:Oncogenes; D012313:RNA / Q000235:genetics; D014158:Transcription, Genetic
D012313:RNA