Morbidity and immunological test in miners working in mines with low ionizing radiation level.
Total count of morbidity as well as prevalence of upper respiratory tract diseases (RTD) were followed in 210 miners working in shale mines with a low level of ionizing radiation regarding their smoking habits. After one and half year of observation were performed some tests of humoral immunity in the blood serum and saliva (immunoglobulins G, A, M and sIgA) as well as some tests of non-specific indices (alpha 2 macroglobulin -A 2M, transferrin -TRF, lysozyme -- LYS). The number of healthy non--smokers reached 41.3%, whereas the number of healthy smokers was only 26.5% (P less than 0.05). The greater was the number of diseases in single subjects, the greater was the difference between smokers and non-smokers (P less than 0.005). The difference between RTD morbidity of smokers and non-smokers was not significant in the subgroup of miners employed less than 10 years, but the length of employment it rose significantly (P less than 0.002) in disfavour of the smokers. The difference between smokers and non-smokers is emphasized by ageing. The mean levels of immunoglobulins (IgG, IgA, IgM) are significantly higher in healthy non-smokers in comparison with other miners; that is stressed also by distribution analysis. The distribution analysis. The distribution of A 2M values is also significantly different in the subgroup of healthy non-smokers compared with other miners. Highly significant differences were found between healthy non-smokers and other miners by discrimination analysis of coupled tests. The differences among the paired comperformed some tests of humoral immunity in the blood serum and saliva (immunoglobulins are apparently cooperative in the prevention of RTD. In contrast to that the level of A 2M are in reverse relationship to the levels of Ig; in the subgroup of healthy non-smokers low levels of A 2M are in connection with high levels of Ig of all three classes. The results are discussed from the point of view of the smoker's habits, the length of employment in mine's environment, the age of the miners and the supposed genetical factors.
D000328:Adult; D001729:Bismuth / Q000009:adverse effects*; D003604:Czechoslovakia; D006801:Humans; D007121:Immunocompetence / Q000528:radiation effects*; D007136:Immunoglobulins / Q000378:metabolism; D007854:Lead / Q000009:adverse effects*; D008297:Male; D008906:Mining; D011009:Pneumoconiosis / Q000276:immunology*; D011059:Polonium / Q000009:adverse effects*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000276:immunology*; D017687:Radon Daughters; D012306:Risk; D012907:Smoking; D014168:Transferrin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D007136:Immunoglobulins; D017687:Radon Daughters; D014168:Transferrin; D000511:alpha-Macroglobulins; D007854:Lead; D011059:Polonium; D001729:Bismuth