The prediction of pregnancy failure by measurement of pregnancy-associated plasma protein A (PAPP-A) following in vitro fertilization and embryo transfer.
Circulating PAPP-A was measured serially in five patients following successful IVF-ET. PAPP-A concentrations were consistently normal in all three patients in whom pregnancies progressed normally to term. Depressed levels of PAPP-A were observed in one patient who miscarried spontaneously at 17 weeks' gestation despite ultrasound evidence of normal fetal development. Circulating PAPP-A was not detected in the fifth patient, whose tubal pregnancy ruptured at 8 weeks. These data are discussed in relation to surveillance of pregnancies following IVF-ET.
D000022:Abortion, Spontaneous / Q000175:diagnosis; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011257:Pregnancy Proteins / Q000032:analysis*; D011271:Pregnancy, Ectopic / Q000175:diagnosis; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*
D011257:Pregnancy Proteins; D011266:Pregnancy-Associated Plasma Protein-A