Demyelinating neuropathy and monoclonal IgM antibody to myelin-associated glycoprotein.
We studied a patient with demyelinating neuropathy and monoclonal IgM kappa antibody to the major myelin-associated glycoprotein (MAG). Binding of this monoclonal antibody to the myelin antigen was demonstrated by immunoelectroblot. Binding to MAG seemed to be specific, because it was completely inhibited by MAG isolated from human myelin. Immunostaining was observed with MAG from CNS and peripheral nervous system myelin.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D002493:Central Nervous System Diseases / Q000276:immunology*; D003711:Demyelinating Diseases / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018993:Myelin P0 Protein; D009185:Myelin Proteins / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D018993:Myelin P0 Protein; D009185:Myelin Proteins