Serotonin in the development of pituitary-adrenocortical response to stress.
Adrenocortical response to intraperitoneal 5-HT administration and immobilization stress is observed in rats as early as the 4th day of life when response to intraventricular administration is still absent. Dexamethasone pretreatment influences plasma corticosteroid response to stimulation of peripheral 5-HT receptors in adult rats but does not alter such response to intraperitoneal 5-HT administration and immobilization in 4-day-old rats. Plasma 11-OHCS response to this stress increases considerably by days 12-16, when stress-induced changes in brain 5-HIAA are also observed. The increase of adrenocortical response to stress coincides with the appearance of brain 5-HT metabolic stress-induced changes as well as pituitary-adrenocortical response to centrally administrators, rather than to brain 5-HT, the latter appearing to become essential for the pituitary-adrenocortical system response to this stress from days 12-16 of life.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000503:physiopathology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001921:Brain / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007103:Immobilization; D008297:Male; D010902:Pituitary Gland / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*
D015062:11-Hydroxycorticosteroids; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D003907:Dexamethasone; D010134:Fenclonine