title: Anti-Wj: an autoantibody that defines a high-incidence antigen modified by the In(Lu) gene.
abstract: An IgG autoantibody, named anti-Wj, reacts with all random and most selected red cell samples. It does not agglutinate cells of Lu(a-b-) type caused by the In(Lu) dominant inhibitor gene, but cells of recessive Lu(a-b-) type are reactive. These data establish that synthesis of the Wj antigen is suppressed by the In(Lu) gene, but it is not a part of the Lutheran blood group system. The Wj antigen is not well developed on fetal red cells. This example of auto anti-Wj is a non-complement-binding IgGl protein that did not appear to cause accelerated in vivo destruction of the patient's red cells.
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D001789:Blood Group Antigens / Q000235:genetics* / Q000276:immunology; D000939:Epitopes; D005260:Female; D005786:Gene Expression Regulation; D005796:Genes; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008188:Lutheran Blood-Group System / Q000235:genetics* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001789:Blood Group Antigens; D000939:Epitopes; D007074:Immunoglobulin G; D008188:Lutheran Blood-Group System