Administration of myelin basic protein-coupled spleen cells prevents experimental allergic encephalitis.
Intravenous administration of mouse myelin basic protein covalently coupled with chromic chloride to syngeneic spleen cells (MBP-SC) prevents the subsequent induction of experimental allergic encephalitis (EAE). Whereas 1 in 28 mice receiving MBP-SC developed EAE after immunization with mouse spinal cord homogenate (MSCH) and adjuvants, 16 out of 25 mice receiving ovalbumin-coupled spleen cells (OA-SC) had EAE following encephalitogenic challenge. The effect of administration of antigen-coupled spleen cells on in vitro proliferation responses is shown.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D001835:Body Weight; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D005260:Female; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D004676:Myelin Basic Protein / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D013154:Spleen / Q000166:cytology*
D000941:Antigens; D004676:Myelin Basic Protein; D010047:Ovalbumin