Effect of mouse interferon on retrovirus production by chronically infected rat cells.
Mouse interferon (IFN) inhibited retrovirus release by both mouse and rat cells with the same efficiency. However, the antiviral state developed more slowly in rat than in mouse cells, and after removal of IFN it also persisted for a longer time in rat than in mouse cells. Under conditions where IFN strongly inhibited virus production it had no effect on cell replication nor on cellular RNA or protein synthesis.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D007372:Interferons / Q000494:pharmacology*; D009052:Leukemia Virus, Murine / Q000254:growth & development; D051379:Mice; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D051381:Rats; D012190:Retroviridae / Q000187:drug effects / Q000254:growth & development*; D009053:Sarcoma Viruses, Murine / Q000254:growth & development
D012313:RNA; D007372:Interferons; D012194:RNA-Directed DNA Polymerase