Effect of new anticancer methanesulfonates on different biochemical parameters of mouse liver.
The comparative effect to two chemically related new synthesized anticancer drugs namely 3,3'-(methylimino) di(l-propanol)dimethanesulfonate(ester)diphenyl disulfonate, No. 838 D (NSC, 140-115) and 3,3' iminodi-l-propanol dimethanesulfonate(ester)p-toluene disulfonate, No. 864 T (NSC, 140-117), on liver DNA, RNA, lipids and glucose-6-phosphatase, after single 100 mg i.p. injection was studied. Both drugs significantly reduced DNA, RNA and total lipid content on day one and two after administration. Normal levels were regained on day three. Both drugs did not cause a decrease in glucose-6-phosphatase activity level, on the contrary, the enzyme was significantly elevated on day three after administration. The present results demonstrate that these drugs induce no severe or permanent damage to hepatic cells in the administered dose.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004247:DNA / Q000378:metabolism; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008698:Mesylates / Q000494:pharmacology*; D051379:Mice; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism
D000970:Antineoplastic Agents; D008698:Mesylates; D011506:Proteins; D012313:RNA; D004247:DNA; D005952:Glucose-6-Phosphatase