title: Inhibitory effect of mouse interferon on the growth of an embryonal carcinoma in mice.
abstract: Embryonal carcinoma cells (F9) were resistant to the inhibitory effects of interferon (IFN) on viral multiplication and cell division in vitro. Nevertheless, daily administration of IFN resulted in a marked inhibition of the growth of this carcinoma injected intraperitoneally (ip) and increased mouse survival time. An incidental finding was that daily IFN treatment increased the serum level of alpha-fetoprotein in normal 129 mice.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000627:therapeutic use*; D051379:Mice; D013724:Teratoma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D007370:Interferon Type I; D000509:alpha-Fetoproteins