Labeling of non poly(A) associated RNA in the rabbit cerebral cortex 24 hours after a single electroconvulsive shock.
The labeling pattern of non poly(A) associated (poly(A)-)RNA of rabbit cerebral cortex was studied 24 hr after a single electroconvulsive shock (ECS). The animals were injected subarachnoidally with [3H]uridine and sacrificed 1 hr later. The fractionation pattern of labeled nuclear poly(A)-RNA in the cerebral cortex of ECS treated animals was identical to that of the controls. However, microsomal poly(A)-RNA from the treated animals showed an increased labeling of 18S ribosomal RNA. Also 28S RNA displayed a higher labeling but the effect was not statistically significant. These results indicate a more efficient production of ribosomal RNA in the late post-ECS period which might be in relationship with an increased activity of brain protein synthesis machinery.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004597:Electroshock; D005260:Female; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D011061:Poly A / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
D009419:Nerve Tissue Proteins; D011061:Poly A; D012313:RNA