title: Further evidence for the possible relationship between neuropeptides and serotonergic neurones in rat spinal cord.
abstract: The relationship between neuropeptides and serotonergic neurones was investigated in rat spinal cord, in vivo, using a subarachnoidal perfusion technique. The 5-hydroxytryptamine (5-HT) release from the spinal cord could be evoked by substance P and peripheral pain stimulation (tail pinch), but not by methionine-enkephalin (met-EK). The substance P-evoked 5-HT release was slightly potentiated by met-EK. The tail pinch-evoked 5-HT release was inhibited by met-EK and baclofen, but potentiated by naloxone. These findings may infer a possible mechanism by which neuroactive peptides regulate 5-HT release from serotonergic neurones in the spinal cord.
mesh_terms: D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000494:pharmacology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009474:Neurons / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D013116:Spinal Cord / Q000378:metabolism*; D013373:Substance P / Q000494:pharmacology
chemical_list: D009419:Nerve Tissue Proteins; D012701:Serotonin; D013373:Substance P; D009270:Naloxone; D004744:Enkephalin, Methionine; D001418:Baclofen; D011188:Potassium