Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP.
MCF-7 human breast cancer cells that were treated for one hour prior to X irradiation with the cyclic AMP-inducing agent 1-methyl-3-isobutylxanthine displayed a slight but significant increase in surviving fraction over untreated controls at each radiation dose level. This was accompanied by a two-fold increase in the level of intracellular cyclic AMP.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006801:Humans; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013806:Theophylline / Q000031:analogs & derivatives*
D011837:Radiation-Protective Agents; D013806:Theophylline; D000242:Cyclic AMP; D015056:1-Methyl-3-isobutylxanthine