Primary intracranial germinoma presenting as lower cranial nerve involvement: case report and review of the literature.
Primary intracranial germinomas are classically known as midline lesions, occurring most commonly in the pineal and suprasellar regions, and will usually present with symptoms related to increased intracranial pressure or hypothalmic dysfunction. Involvement of both the pineal and the suprasellar region in the same patient (double midline lesions) is relatively rare (7%). Dissemination of germinoma to both cerebellopontine angles, in addition to the double midline lesions, with the initial clinical presentation of lower cranial nerve involvement has not been previously reported. We encountered such an unusual case, which prompted this report and review of the literature.
D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000175:diagnosis; D002530:Cerebellopontine Angle; D006063:Chorionic Gonadotropin / Q000032:analysis; D004407:Dysgerminoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary; D010870:Pineal Gland; D014057:Tomography, X-Ray Computed; D000160:Vestibulocochlear Nerve Diseases / Q000209:etiology*; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins