Inhibition of fast axonal transport by erythro-9-[3-(2-hydroxynonyl)]adenine.
erythro-9-[3-(2-Hydroxynonyl)]adenine, an inhibitor of protein carboxylmethylation and dynein-ATPase activity, inhibited fast axonal transport in vitro in frog sciatic nerves. Its site of action might be associated with an ATPase on which transport depends, since specific carboxylmethylation inhibitors lacked effects on transport. The levels of high energy phosphates and protein synthesis were unaffected by the drug at a transport-inhibiting concentration, making disturbances due to metabolic effects less likely. An erythro-9-[3-(2-hydroxynonyl)]adenine-sensitive ATPase was looked for in various nerve fractions but has so far not been resolved.
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D003515:Cycloleucine / Q000494:pharmacology; D003839:Deoxyadenosines; D011893:Rana esculenta; D011896:Rana temporaria; D012584:Sciatic Nerve / Q000378:metabolism*; D013872:Thionucleosides / Q000494:pharmacology
D003839:Deoxyadenosines; D013872:Thionucleosides; D003515:Cycloleucine; D000249:Adenosine Monophosphate; C010192:9-(2-hydroxy-3-nonyl)adenine; D000244:Adenosine Diphosphate; C008500:5'-methylthioadenosine; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases; D000225:Adenine; D000241:Adenosine