title: Diffuse embryoma of the testis. A distinctive form of mixed germ cell tumor.
abstract: Two testicular tumors characterized by a diffuse, orderly arrangement of embryonal, yolk sac, and trophoblastic elements are described as examples of a newly recognized form of mixed germ cell neoplasia. In one case, ribbons of embryonal carcinoma and yolk sac tumor wound around one another to create a distinctive necklace pattern. In the second case, differentiation of the yolk sac component was more advanced with the formation of numerous clusters of cells resembling hepatocytes. Tumors with these patterns are appropriately designated diffuse embryomas to distinguish them from polyembryomas and other forms of malignant mixed germ cell tumor.
mesh_terms: D000328:Adult; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis; D006801:Humans; D008297:Male; D013724:Teratoma / Q000145:classification / Q000473:pathology*; D009626:Terminology as Topic; D013736:Testicular Neoplasms / Q000145:classification / Q000473:pathology*; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins