title: Learned histamine release.
abstract: Most of the effort directed at understanding the problems of allergy has focused on the interacting components of the immune system. The possibility that histamine may be released as a learned response has now been tested. In a classical conditioning procedure in which an immunologic challenge was paired with the presentation of an odor, guinea pigs showed a plasma histamine increase when presented with the odor alone. This suggests that the immune response can be enhanced through activity of the central nervous system.
mesh_terms: D000818:Animals; D003214:Conditioning, Classical; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood; D006636:Histamine Release; D006967:Hypersensitivity / Q000503:physiopathology; D008297:Male; D009812:Odorants
chemical_list: D006632:Histamine