Inhibition of the recovery from potentially lethal damage by lonidamine.
Lonidamine [1-(2,4-dichlorobenzyl)-1-H-indazol-3-carboxylic acid] is shown to inhibit recovery from potentially lethal damage after exposure of cells to X-rays, methyl methane sulfonate, or bleomycin and heat (43 degrees C, 1h). Inhibition is most effective when the drug is present before and after exposure of 10 to 25 mg l-1, a concentration readily achievable in vivo.
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D006224:Cricetinae; D003412:Cricetulus; D006358:Hot Temperature; D007191:Indazoles / Q000494:pharmacology*; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology*; D013997:Time Factors
D007191:Indazoles; D011720:Pyrazoles; D001761:Bleomycin; D008741:Methyl Methanesulfonate; C016371:lonidamine