title: Correlations of glucose metabolism and structural damage to language function in aphasia.
abstract: Studies of aphasic patients using [18F]fluorodeoxyglucose positron computed tomographs have shown areas of metabolic depression in the left hemisphere larger than the area of infarction noted on CT. To evaluate these metabolic differences in relationship to language abnormalities, 11 patients had metabolic scans, CT, and were administered the Boston Diagnostic Aphasia Battery and the Porch Index of Communicative Ability. Correlation analyses were computed between metabolic, CT, and language data. CT demonstrated reliable correlations of speaking, oral reading, and repetition to Wernicke' area, consistent with current anatomic language models, while metabolic data from areas posterior, inferior, and superior to the traditional Wernicke's area and the head of the caudate nucleus also had reliable correlations with aphasic language function. The utilization of both structural and metabolic brain measures may improve our understanding of the anatomy of language as related to aphasia.
mesh_terms: D000328:Adult; D000368:Aged; D001037:Aphasia / Q000175:diagnosis*; D001786:Blood Glucose / Q000378:metabolism*; D001925:Brain Damage, Chronic / Q000000981:diagnostic imaging*; D001930:Brain Injuries / Q000000981:diagnostic imaging; D001931:Brain Mapping; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose