Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum alpha-fetoprotein.
A 13-year-old girl had an ovarian Sertoli-Leydig cell tumor associated with marked elevation of the serum alpha-fetoprotein level. On microscopic examination, the tumor had a predominantly retiform pattern and in addition contained heterologous elements in the form of mucinous epithelium, skeletal muscle, and liver cells; alpha-fetoprotein was demonstrated within the liver cells by immunohistochemical techniques. The serum alpha-fetoprotein level fell postoperatively, but rose again when the tumor recurred. Despite radiation therapy and chemotherapy, the tumor pursued a rapidly malignant course and the patient died 9 months postoperatively.
D000293:Adolescent; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007984:Leydig Cell Tumor / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012707:Sertoli Cell Tumor / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins