Salivary levels of gramicidin after use of a tyrothricin lozenge and a tyrothricin gargle/mouth-wash.
Salivary levels and total salivary recovery of gramicidin were determined by high performance liquid chromatography in healthy volunteers after administration of a tyrothricin lozenge and a tyrothricin gargle/mouth-wash. Average peak values of gramicidin after sucking the lozenge were 37.5 mg/l and were usually reached within the five minutes. After use of the lozenge mean total recovery of gramicidin in saliva was 44% within the first 30 minutes. After application of the gargle/mouth-wash about 11% was retained in the oral cavity and excreted with saliva within the following 30 minutes. The implications of these findings are discussed.
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004304:Dosage Forms; D005260:Female; D006096:Gramicidin / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D009067:Mouthwashes; D012463:Saliva / Q000378:metabolism*; D014449:Tyrothricin / Q000008:administration & dosage* / Q000378:metabolism
D004304:Dosage Forms; D009067:Mouthwashes; D014449:Tyrothricin; D006096:Gramicidin