Additive effects of acyclovir and immune transfer in neonatal herpes simplex virus infection in mice.
Acyclovir had a dose-dependent, mild, but significant, inhibitory effect on interferon-stimulated human antiviral natural killer cytotoxicity in vitro. In a murine model of neonatal herpes simplex virus infection, acyclovir significantly (P < 0.05) increased survival afforded by the injection of human interferon and human mononuclear leukocytes from 67.8 to 88.6%.
D000212:Acyclovir / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D006561:Herpes Simplex / Q000276:immunology / Q000628:therapy*; D007116:Immunization, Passive; D007372:Interferons / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL
D007372:Interferons; D000212:Acyclovir