Immunoreactive myelin proteolipid, protein-like activity in cerebrospinal fluid and serum of neurologically impaired patients.
Two hundred seventy-eight samples of cerebrospinal fluid and 273 samples of sera from a variety of neurological patients were examined by radioimmunoassay for myelin proteolipid protein-like reactivity as an index of structural damage to myelin. Groups of patients with active central nervous system damage could be distinguished easily, although there was a small percentage of false positive reactions. The reactivity was most marked in the demyelinative, encephalitic, and stroke categories. A radioimmunoassay for proteolipid protein of proper sensitivity and specificity may prove to be a useful objective clinical measure of the presence and degree of disease activity in multiple sclerosis and other diseases.
D001925:Brain Damage, Chronic / Q000378:metabolism; D002544:Cerebral Infarction / Q000378:metabolism; D006801:Humans; D009103:Multiple Sclerosis / Q000378:metabolism; D009185:Myelin Proteins / Q000378:metabolism*; D018991:Myelin Proteolipid Protein; D009186:Myelin Sheath / Q000378:metabolism; D009188:Myelitis, Transverse / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism*; D009896:Optic Atrophy / Q000378:metabolism; D009902:Optic Neuritis / Q000378:metabolism; D011863:Radioimmunoassay
D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein