Effect of ethanol ingestion on the nucleocytoplasmic transport of hepatic RNA.
Influence of prolonged ethanol ingestion on the nucleocytoplasmic transport of RNA has been examined in a cell-free system. The nucleocytoplasmic transport of RNA was energy- and temperature-dependent. Ethanol treatment of rats for 10 weeks led to a significant increase in the release of isotopically labelled nuclear RNA from the nucleus, suggesting a partial loss of nuclear restrictive control. Results from crossover experiments led to the conclusion that the observed effect of ethanol ingestion was mediated through factors present in the cytosol as well as in the nuclear fraction.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D000431:Ethanol / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D012313:RNA / Q000378:metabolism*; D051381:Rats
D000431:Ethanol; D012313:RNA