Nitrilotriacetic acid does not induce sister-chromatid exchanges in hamster or human cells.
The effect of nitrilotriacetic acid on sister-chromatid exchanges (SCEs) in human peripheral blood lymphocytes and Chinese hamster ovary cells was studied. The chemical did not increase the frequency of SCEs in either cell type. The negative response of these cells supports other evidence that nitrilotriacetic acid is not genotoxic and that its carcinogenicity to the urinary tract may involve an epigenetic mechanism.
D000085:Acetates / Q000633:toxicity*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D009571:Nitrilotriacetic Acid / Q000633:toxicity*; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013194:Staining and Labeling
D000085:Acetates; D009571:Nitrilotriacetic Acid