[Transportal hyperalimentation with fat emulsion as the treatment of experimental acute pancreatitis].
Twenty dogs were divided into four groups. Group A; IVH without Fat emulsion was performed transvenously. Group B: IVH with Fat emulsion transvenously. Group C; IVH without Fat emulsion transportally. Group D: IVH with Fat emulsion transportally. Infusion dose was for 24 hours. The results were as follows: 1) Blood sugar and I.R.L.: In group B and D, both blood sugar and I.R.I. reached the peak at the 24th hour. However, in the 1st week, they became normal value. In group D, Blood sugar was higher than that in group B, but I.R.I. value was lower. 2) Free fatty acid (FFA): in group A and C, FFA were gradually increased, but in group B and D, they reached the preoperative value in the 1st week. In group D, it was lower than that in group B. 3) Histological findings of the liver: in group A-D, lobular necrosis and fat degeneration were seen. In this study, we emphasized that transportal hyperalimentation with fat emulsion as the treatment of acute pancreatitis was physiologically effective especially in control of blood sugar and inhibition of lipolysis.
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D010195:Pancreatitis / Q000628:therapy*; D011169:Portal Vein; D000515:alpha 1-Antitrypsin / Q000097:blood
D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D000515:alpha 1-Antitrypsin; D000681:Amylases