Cytoprotective effect of prostacyclin and protein synthesis.
It is shown that de novo synthesis of protein is essential for the healing process of experimental gastric ulcer and that the cytoprotective effect of prostacyclin is connected with protein synthesis. In preliminary experiments the influence of prostacyclin on hepatic protein synthesis has also been shown.
D000818:Animals; D003609:Dactinomycin / Q000031:analogs & derivatives / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects; D014176:Protein Biosynthesis; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000378:metabolism
C030013:cactinomycin; D003609:Dactinomycin; D011691:Puromycin; D011464:Epoprostenol