Substance p reversal of electroconvulsive shock and cycloheximide-induced retrograde amnesia.
Subcutaneous post-trial administration of the neuropeptide substance P was found to reverse the amnestic effects of both electroconvulsive shock and cycloheximide. Substance P was observed to reverse the amnestic effects of cycloheximide in both C57B1/6J and heterogeneous strain (HS) mice. Substance P was found to reverse the amnestic effects of electroconvulsive seizures in C57B1/6J animals. Peripheral injections of substance P were also found to facilitate the retention of a single-trial passive avoidance habit in animals of both genotypes, provided a weak footshock was used during training.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology*; D004597:Electroshock; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009115:Muridae; D012153:Retention, Psychology / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D003513:Cycloheximide