The structure of a serotonin and LSD binding site of myelin basic protein.
Experiments have established the presence of a serotonin binding site in the tryptophan region of myelin basic protein. LSD competes for this binding site in vivo and in vitro. Although previous models have been suggested for the site, these models failed to explain the results of serotonin modification studies or the mode of LSD binding to the site. A new model of the site is proposed to rectify these problems. Means of testing the model are suggested. Implications for understanding neuroreceptor physiology, specificity, and disease are discussed. The name "molecular sandwiching" is suggested to describe the binding process.
D001665:Binding Sites; D008238:Lysergic Acid Diethylamide / Q000378:metabolism*; D008958:Models, Molecular; D004676:Myelin Basic Protein / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism
D004676:Myelin Basic Protein; D012701:Serotonin; D014364:Tryptophan; D008238:Lysergic Acid Diethylamide