Acting mechanisms of Lentinan in human--II. Enhancement of non-specific cell-mediated cytotoxicity as an interferon inducer.
The immunopotentiator "Lentinan" augmented the cell-mediated cytotoxicity in humans. (a) The activation of killer T cells by the mixed lymphocyte culture was accelerated only when responder cells were mixed with both a suboptimum number of stimulator cells and Lentinan. (b) The interferon level in the peripheral blood circulation of cancer patients was elevated in 12 h following Lentinan administration, and natural killer activity of peripheral mononuclear cells was enhanced in 48 h. These data indicate that Lentinan favorably affects the host mechanisms of man.
D002759:Adenoma, Bile Duct / Q000378:metabolism; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000032:analysis / Q000494:pharmacology / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology; D007912:Lentinan / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D007369:Interferon Inducers; D011134:Polysaccharides; D007912:Lentinan; D007372:Interferons