Prostaglandin synthesis inhibition with indomethacin in ACTH-induced hypertension.
The short- and long-term effects of indomethacin administration were examined in normotensive and ACTH-induced hypertensive conscious sheep. Indomethacin, 1 mg/kg/h for 60 min, caused a transient rise in mean arterial pressure (MAP) and calculated total peripheral resistance (CTPR) and a fall in cardiac output in normotensive sheep. In sheep with ACTH hypertension, these haemodynamic effects were prolonged. Indomethacin infusion at 3 mg/kg/day for 3 days had no observable haemodynamic or metabolic effects. Concomitant infusion of ACTH increased MAP and CTPR. These studies suggest prostaglandins play only a minor role in regulation of blood pressure in normal conscious sheep, but modulate the blood pressure rise in ACTH hypertension in sheep.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D012083:Renin / Q000097:blood; D012756:Sheep; D014655:Vascular Resistance / Q000187:drug effects
D011453:Prostaglandins; D000324:Adrenocorticotropic Hormone; D012083:Renin; D007213:Indomethacin