Differential rates of loss of chromosomes aberrations in rat thyroids after X rays or neutrons.
Rat thyroid glands were exposed in vivo to 5.5-Gy X rays or 2.75-Gy neutrons (14.7 MeV) and cell proliferation was stimulated by goitrogen treatment at various intervals up to 48 weeks postirradiation. The amount of chromosome damage in stimulated follicular cells declined much more slowly after neutron than X irradiation, suggesting differential repair. This observation may be relevant to the question of residual cellular damage and oncogenesis after X rays and neutrons.
D000640:Amitrole / Q000494:pharmacology; D000705:Anaphase / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology; D002869:Chromosome Aberrations; D005214:Fast Neutrons; D008297:Male; D009502:Neutrons; D051381:Rats; D011919:Rats, Inbred Strains; D013692:Telophase / Q000187:drug effects / Q000528:radiation effects; D013961:Thyroid Gland / Q000187:drug effects / Q000528:radiation effects* / Q000648:ultrastructure; D013997:Time Factors
D013956:Antithyroid Agents; D000640:Amitrole