Functional analogs of bleomycin: sequence-specific DNA cleavage with porphyrin (Fe) intercalators.
Synthetic porphyrin (Fe) intercalators cleave DNA at guanine-cytosine and guanine-thymine sequences. The specificity for cleavage of base sequences of DNA is quite similar to that of bleomycin.
D001483:Base Sequence; D001761:Bleomycin; D004247:DNA; D005971:Glutamates; D006418:Heme / Q000031:analogs & derivatives*; D006868:Hydrolysis; D007093:Imidazoles; D007364:Intercalating Agents; D011166:Porphyrins
D005971:Glutamates; D007093:Imidazoles; D007364:Intercalating Agents; D011166:Porphyrins; D001761:Bleomycin; D006418:Heme; C023785:2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; D004247:DNA; C042646:TPP-SP-G; C042647:HEM-2G