title: Antigenic variation during the developmental cycle of Trypanosoma brucei.
abstract: During the complex life cycle of Trypanosoma brucei, changes in the exposed surface antigens occur in both the mammalian host and the insect vector (Glossina spp.). These antigenic changes are associated with alterations of the variant surface glycoprotein (VSG) composition or with the loss of the VSG. In the bloodstream of the mammalian host, trypanosomes successfully evade destruction by the host's immune response by continuously expressing alternative VSGs, at low frequency, which are not destroyed by host antibodies. When ingested by the tsetse fly, the bloodstream trypanosomes rapidly lose their surface coat and surface membrane antigens are exposed which are normally covered in the bloodstream. In the salivary glands of the tsetse fly, the trypanosomes differentiate to the metacyclic stage, which reacquires a surface coat. The antigenic composition of the metacyclics is heterogeneous. The same metacyclic types are expressed regardless of the bloodstream antigenic type ingested by the tsetse fly. In the mammal the metacyclics differentiate to long-slender bloodstream forms but continue to express the metacyclic VSG for at least three days. The next VSGs expressed in the mammalian host appear to be influenced by the antigenic type ingested by the tsetse. The ingested antigenic type is often expressed in the first parasitemia following expression of the metacyclic antigenic types.
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D000242:Cyclic AMP / Q000378:metabolism; D000939:Epitopes; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D006790:Host-Parasite Interactions; D007114:Immunization; D007165:Immunosuppression Therapy; D007303:Insect Vectors / Q000469:parasitology*; D051379:Mice; D008807:Mice, Inbred BALB C; D012469:Salivary Glands / Q000469:parasitology; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D014353:Trypanosomiasis, African / Q000276:immunology / Q000469:parasitology*; D014370:Tsetse Flies / Q000469:parasitology*; D014643:Variant Surface Glycoproteins, Trypanosoma
chemical_list: D000954:Antigens, Surface; D000939:Epitopes; D006023:Glycoproteins; D014643:Variant Surface Glycoproteins, Trypanosoma; D000242:Cyclic AMP