Hyperplasia and hypertrophia in the denervated and distended rat urinary bladder.
The parasympathetically denervated and distended rat urinary bladder was found to have increased fourfold in weight when examined 3 weeks postoperatively. Both in muscularis and mucosa of such a bladder the synthesis of proteins, RNA and DNA was increased severalfold. An increase in the polyamines putrescine, spermidine and spermine was also found; these polyamines are usually linked to protein synthesis. The results suggest that the cells of the two layers increase both in size and number. Hyperplasia was, in a previous study, suggested as a possible explanation for a right-ward shift of the active length-tension curve of muscle strips in the denervated rat urinary bladder.
D000818:Animals; D002103:Cadaverine / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D003714:Denervation; D006965:Hyperplasia; D006984:Hypertrophy; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology; D011700:Putrescine / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D001743:Urinary Bladder / Q000294:innervation / Q000378:metabolism / Q000473:pathology*
D013096:Spermine; D012313:RNA; D004247:DNA; D002103:Cadaverine; D013095:Spermidine; D011700:Putrescine