[Inhibition of the hemolytic activity of influenza viruses by antibody].
Haemolysis caused by influenza viruses is known to occur below pH 6; the pH-optimum for each virus strain is different. Clear dose-effect correlations were found to prevail between the amount of haemolysis and virus concentration. Antibody-mediated inhibition of haemolysis has been investigated with the strain A/PR/8/34 (H1N1) and the recombinant X-73 (H3N2). Inhibition of haemolysis by antisera against different influenza. A virus subtypes suggests that haemolysis inhibiting antibodies are not identical with haemagglutination inhibiting antibodies. The action of antibodies directed against host-cell specific components was excluded by adsorption procedures. Haemolysis inhibiting antibodies are thought to be directed against antigenic determinants of the haemagglutinin functioning as fusion factor.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D002645:Chickens / Q000097:blood; D000939:Epitopes / Q000276:immunology; D006387:Hemagglutination, Viral; D006461:Hemolysis; D007106:Immune Sera / Q000276:immunology; D007163:Immunosorbent Techniques; D009980:Influenza A virus / Q000276:immunology* / Q000502:physiology
D000914:Antibodies, Viral; D000939:Epitopes; D007106:Immune Sera
Hemmung der hämolytischen Aktivitäten von Influenzaviren durch Antikörper.