[Hormone receptors: theoretical and experimental aspects of the effect of steroid hormones].
The association of steroids with their cytosol receptors is the first stage in the mechanism of action of steroid hormones. Translocation of the steroid-receptor complex to the nucleus results in the binding of the hormone-receptor complex to chromatin. Subsequently, this process alters gene expression. Oestrogens augment gene expression, leading to cell proliferation and stimulation of protein synthesis. Progesterone may blunt gene expression and antioestrogens act similarly, e.g. tamoxifen inhibits both DNA and protein synthesis. Determination of steroid receptors is a routine diagnostic tool for the management of patients with breast and endometrial cancer.
D001667:Binding, Competitive; D002455:Cell Division; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013629:Tamoxifen / Q000494:pharmacology
D002843:Chromatin; D004967:Estrogens; D011956:Receptors, Cell Surface; D013629:Tamoxifen; D011374:Progesterone; D004958:Estradiol; D012313:RNA; D004247:DNA
Hormonrezeptoren: Theoretische und experimentelle Aspekte der Wirkung von Steroidhormonen.