Substance P receptors in the nervous system and possible receptor subtypes.
The ability of various related peptides and substance P analogues to compete for the binding of 3H-labelled substance P to rat brain membranes corresponds with their known biological activities, providing a simple model for studies of peptide receptors in the central nervous system. In salivary gland and brain slices substance P and related peptides stimulate the rate of incorporation of phosphatidylinositol, offering an alternative biochemical model for substance P receptor studies. Two types of receptor may be responsible for the actions of substance P on peripheral tissues: the SP-P type, where all tachykinins are approximately equally active, and the SP-E type, where eledoisin and kassinin are more potent than the other tachykinins. Alkyl esters of substance P appear to act as selective SP-P agonists.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D004600:Eledoisin / Q000494:pharmacology; D015286:Kassinin; D009130:Muscle, Smooth / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018040:Receptors, Neurokinin-1; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism; D012472:Salivation / Q000187:drug effects; D013329:Structure-Activity Relationship; D013373:Substance P / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D015320:Tachykinins; D014316:Tritium; D000516:alpha-Amylases / Q000378:metabolism
D009842:Oligopeptides; D010455:Peptides; D010716:Phosphatidylinositols; D011956:Receptors, Cell Surface; D018040:Receptors, Neurokinin-1; D015320:Tachykinins; D014316:Tritium; D013373:Substance P; D015286:Kassinin; D004600:Eledoisin; D000516:alpha-Amylases