Inhibition by vasoactive intestinal peptide of antigen-induced histamine release from guinea-pig minced lung.
Vasoactive intestinal peptide (VIP) was found to inhibit ovalbumin-induced histamine release from guinea-pig minced lung. Maximum inhibition occurred with a 10-20 min time of preincubation with VIP. Spontaneous histamine release was not altered by VIP. With 2 x 10(-6) M VIP, the dose-response curve to ovalbumin was shifted about 3-fold to the right, but the maximum histamine release was unaltered. Respiratory tract infection with parainfluenza 3 virus did not influence the inhibitory effect of VIP on histamine release.
D000818:Animals; D000941:Antigens; D005260:Female; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D008168:Lung / Q000187:drug effects / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D010224:Parainfluenza Virus 3, Human; D018184:Paramyxoviridae Infections / Q000276:immunology; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D000941:Antigens; D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D010047:Ovalbumin