Cell-diffusion precipitin analysis of mixed IgM-IgG cryoglobulins. An unusual kappa-chain determinant of the IgM component.
Antigenic features of monoclonal IgM kappa components of three mixed IgM-IgG cryoglobulins were studied by gel-diffusion precipitin analysis. An unusual kappa-chain determinant was revealed in the IgM components but not in other monoclonal immunoglobulins (IgM kappa, BJ kappa) or normal IgG. Antibodies to this determinant were found not only in anti-kappa, but also in anti-lambda sera, and in antisera to hidden determinants of L-chains.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001536:Bence Jones Protein / Q000276:immunology; D003450:Cryoglobulins / Q000032:analysis*; D000939:Epitopes / Q000032:analysis; D006801:Humans; D007106:Immune Sera / Q000032:analysis; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis*; D007147:Immunoglobulin Light Chains / Q000032:analysis / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis* / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000276:immunology; D011234:Precipitins / Q000032:analysis*; D011817:Rabbits
D000888:Antibodies, Anti-Idiotypic; D003450:Cryoglobulins; D000939:Epitopes; D007106:Immune Sera; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D011234:Precipitins; D001536:Bence Jones Protein