title: Effect of gamma interferon preparations on in vitro phagocytosis and degradation of Escherichia coli by mouse peritoneal macrophages.
abstract: Treatment of mouse peritoneal macrophages by gamma (type II, immune) interferon depressed the ingestion of non-opsonized Escherichia coli mediated by the non specific receptor, and also the intracellular degradation of the ingested bacteria. These effects were time and dose-dependent, and sensitive for trypsin and pH 2 treatment. The intracellular concentration of three lysozomal enzymes, beta-glucuronidase, acid phosphatase and cathepsin D, was elevated in gamma interferon-treated macrophages.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D001202:Ascitic Fluid / Q000166:cytology; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D002403:Cathepsins / Q000378:metabolism; D002478:Cells, Cultured; D004926:Escherichia coli / Q000276:immunology; D005966:Glucuronidase / Q000378:metabolism; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes; D008264:Macrophages / Q000201:enzymology / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*
chemical_list: D007372:Interferons; D000135:Acid Phosphatase; D005966:Glucuronidase; D002403:Cathepsins