title: [Immunopathogenesis of polyneuropathies in paraproteinemia].
abstract: Polyneuropathies are the most common neurological complications of paraproteinemias . In many cases pathogenesis remains unclear. In two patients with chronic demyelinating neuropathy in IgM-paraproteinaemia subtle methods were applied ( immunoelectroblot and immunocytochemistry). It could be demonstrated that the pathologic antibodies in the patients' serum reacted specifically with an antigen in the sheath, the myelin-associated glycoprotein. These observations suggest an antibody-mediated immunopathogenesis of the patients' polyneuropathy and invite prospects for a rational treatment with immunosuppressive approaches.
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D000936:Antigen-Antibody Complex; D001706:Biopsy; D006801:Humans; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D008297:Male; D009133:Muscular Atrophy / Q000209:etiology*; D009185:Myelin Proteins / Q000276:immunology; D018992:Myelin-Associated Glycoprotein; D009474:Neurons / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications*; D012032:Refractory Period, Electrophysiological; D014202:Tremor / Q000209:etiology*
chemical_list: D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein
vernacular_title: Immunpathogenese der Polyneuropathien bei Paraproteinämie.