[Alpha 2-macroglobulin: structure, properties and physiological role].
The paper is concerned with the results of recent researches devoted to studies of the structure, properties and physiological role of alpha 2-macroglobulin, one of main inhibitors of blood proteolytic enzymes. Data are presented on its primary and quaternary structure, mechanisms of interaction with proteinases. The role of alpha 2-macroglobulin in regulation of the activity of proteinases participating in blood coagulation, fibrinolysis, kininogenesis, immune reactions is shown. Possibilities of its application in medicine are discussed.
D000595:Amino Acid Sequence; D000818:Animals; D001797:Blood Protein Electrophoresis; D002241:Carbohydrates / Q000032:analysis; D003937:Diagnosis, Differential; D006525:Hepatitis, Viral, Human / Q000097:blood; D006801:Humans; D009369:Neoplasms / Q000097:blood; D011480:Protease Inhibitors; D011487:Protein Conformation; D011833:Radiation Injuries, Experimental / Q000188:drug therapy; D051381:Rats; D013379:Substrate Specificity; D000511:alpha-Macroglobulins / Q000032:analysis / Q000502:physiology* / Q000627:therapeutic use
D002241:Carbohydrates; D011480:Protease Inhibitors; D000511:alpha-Macroglobulins
Alpha 2-makroglobulin: struktura, svoĭstva i fiziologicheskaia rol'.