Tunicamycin enhances the antiviral and anticellular activity of interferon.
The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D004357:Drug Synergism; D005944:Glucosamine / Q000031:analogs & derivatives*; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D014415:Tunicamycin / Q000494:pharmacology*; D014762:Viral Interference / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
D014415:Tunicamycin; D007372:Interferons; D005944:Glucosamine