The effects of mirex on the neonatal rat lens in vitro, with a comparison to kepone.
Lenses were removed from 12-day-old rats and incubated in medium containing 20 microM mirex. Lenses were removed from the medium at 2, 4, 6, and 8 h and assayed for K+ and Na+ concentrations and hydration. Mirex had no in vitro effect on these lens parameters compared to controls, and produced no changes in lens clarity. In contrast, incubation for 8 h in medium containing 20 microM kepone resulted in elevated lens Na+ and lower lens K+. Thus, cataracts induced by mirex in vivo are probably not due to a direct toxic effect on the lens.
D000818:Animals; D007631:Chlordecone / Q000633:toxicity*; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D007908:Lens, Crystalline / Q000032:analysis / Q000187:drug effects*; D008917:Mirex / Q000633:toxicity*; D011188:Potassium / Q000032:analysis; D011247:Pregnancy; D051381:Rats; D012964:Sodium / Q000032:analysis
D007306:Insecticides; D012964:Sodium; D007631:Chlordecone; D011188:Potassium; D008917:Mirex