title: [Comparative analysis of the biophysical characteristics of influenza A virus variants with differing pathogenicity for mice].
abstract: Variants of influenza A virus: A/PR8/34 Pm-, nonpathogenic for mice and A/PR8/34 Pm+, pathogenic for mice, obtained after 5 passages in mice, were studied. Both variants showed close similarities in the antigenic specificity, high reproductive activity at optimal temperature and reduced activity at low and high temperatures, similar plaque-producing activity in chick fibroblast cell cultures. Differences in their polypeptide composition were found. The A/PR8/34 Pm+ variant had no HAO and a lower molecular weight of HA1. In the mapping of HA1 and NP proteins, differences in the oligopeptide compositions were observed.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D055592:Biophysical Phenomena; D001703:Biophysics; D002642:Chick Embryo; D000939:Epitopes / Q000032:analysis; D014644:Genetic Variation; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000032:analysis / Q000235:genetics / Q000472:pathogenicity*; D051379:Mice; D009842:Oligopeptides / Q000032:analysis; D010455:Peptides / Q000032:analysis
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral; D009842:Oligopeptides; D010455:Peptides
vernacular_title: Sravnitel'nyĭ analiz biofizicheskikh kharakteristik variantov virusov grippa A s raznoĭ patogennost'iu dlia mysheĭ.