[An unusual renal tumor, associating nephroblastoma, nephroblastomatosis, teratoma, and cystic dysplasia with arterial hypertension and secretion of alpha-fetoprotein].
The authors report the case of a very unusual kidney tumour discovered in a newborn infant known to have abnormal dense and cystic structures in both kidneys already during the intra-uterine period as a result of antenatal echotomography. Severe hypertension developed on the 10th day of life, accompanied by the hypersecretion of angiotensin. Right nephrectomy of the multicystic and poorly functioning kidney resulted in the normalisation of blood pressure. A left lower polar nephrectomy for tumour finally gave a good result, with three years' follow-up. Histology of the right kidney revealed a nephroblastoma with cystic dysplasia, areas of nephroblastomatosis and the secretion of alpha-foetoprotein, in the nephroblastomatous tubular structures. On the left, there was a nephroblastoma associated with areas of nephroblastomatosis.
D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000151:congenital*; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000151:congenital* / Q000378:metabolism; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000151:congenital; D009392:Nephrectomy; D007690:Polycystic Kidney Diseases / Q000151:congenital*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013724:Teratoma / Q000151:congenital*; D014463:Ultrasonography; D009396:Wilms Tumor / Q000151:congenital*; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins
Une tumeur rénale inhabituelle, associant un néphroblastome, une néphroblastomatose, un tératome, une dysplasie kystique, à une hypertension artérielle et à une sécrétion d' alpha-foetoprotéine.