The differing responses of four muscle types to dexamethasone treatment in the rat.
The glucocorticoid dexamethasone dramatically altered growth patterns in four muscle types, inducing atrophy of smooth and fast-twitch skeletal muscle, suppressing protein accumulation in slow-twitch muscle and enhancing growth in the heart. These differing responses were explained by steroid-induced changes in RNA content, protein synthesis and protein breakdown.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007700:Kinetics; D008297:Male; D024510:Muscle Development; D009124:Muscle Proteins / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D051381:Rats
D009124:Muscle Proteins; D012313:RNA; D003907:Dexamethasone