Possible involvement of folate cycle in the pathogenesis of amyotrophic lateral sclerosis.
The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous tissue of this disease.
D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D005492:Folic Acid / Q000378:metabolism*; D006801:Humans; D009044:Motor Cortex / Q000378:metabolism; D009046:Motor Neurons / Q000502:physiology; D009420:Nervous System / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis / Q000378:metabolism
D012313:RNA; D004247:DNA; D005492:Folic Acid