Interferon induces natural killer cell blastogenesis in vivo.
Interferon (IFN), types beta and gamma, and IFN inducers polyinosinic-polycytidylic acid and lymphocytic choriomeningitis virus all stimulated the generation of blast-NK cells in mouse spleens. Blast-NK cells were characterized on the basis of size, 3H-thymidine uptake, and NK cell markers. These data indicate that in addition to augmenting NK cell-mediated lysis, IFN may regulate NK cell proliferation in vivo.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D007372:Interferons / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D051379:Mice; D011070:Poly I-C / Q000494:pharmacology
D000954:Antigens, Surface; D000956:Antigens, Viral; D007372:Interferons; D011070:Poly I-C