Role of prostaglandins in the renal response to angiotensin-converting enzyme inhibition and renal artery occlusion.
We investigated the role of prostaglandins in the renal effects of endogenous kinins in anaesthetized dogs. Endogenous kinin levels, as indicated by urinary kinin excretion, were increased by angiotensin-converting enzyme inhibition or by 10-min renal artery occlusion. Angiotensin-converting enzyme inhibition with captopril resulted in increased renal blood flow that was not prevented by prior inhibition of prostaglandin synthesis with indomethacin. The renal vasodilation after temporary renal artery occlusion was also not altered by indomethacin treatment. Thus both angiotensin-converting enzyme inhibition and renal artery occlusion caused increased kinin levels and renal vasodilation that was not dependent on prostaglandins. These results also suggest that intrarenal kinins have a role in the control of renal blood flow.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D004285:Dogs; D007213:Indomethacin / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives*; D011453:Prostaglandins / Q000502:physiology*; D012077:Renal Artery / Q000502:physiology*; D012079:Renal Circulation / Q000187:drug effects; D014664:Vasodilation
D000806:Angiotensin-Converting Enzyme Inhibitors; D011453:Prostaglandins; D011392:Proline; D002216:Captopril; D007213:Indomethacin