Nasopharyngeal lymphoepithelioma. Histological diagnosis as aided by immunohistochemical demonstration of keratin.
Eight cases of primary and metastatic nasopharyngeal lymphoepithelioma and four cases of malignant lymphoma of the pharyngeal region were studied for the presence of keratin by indirect immunofluorescence microscopy. The results showed that all the cases of primary and metastatic lymphoepithelioma contained keratin-positive cells, whereas all the lymphomas were negative for keratin. Anti-keratin antibody thus seems to be a valuable aid in the differential diagnosis between lymphoepithelioma and lymphoma.
D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000473:pathology*; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006801:Humans; D007633:Keratins / Q000032:analysis*; D008223:Lymphoma / Q000032:analysis / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000032:analysis / Q000473:pathology*; D009362:Neoplasm Metastasis; D010610:Pharyngeal Neoplasms / Q000032:analysis / Q000473:pathology
D007633:Keratins