Aucubin: potential antidote for alpha-amanitin poisoning.
Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration. A possible mechanism of protective activity is partly due to a competitive effect of aucubin on alpha-amanitin inhibition of liver RNA biosynthesis.
D000284:Administration, Oral; D000546:Amanitins / Q000633:toxicity*; D000818:Animals; D000931:Antidotes / Q000008:administration & dosage / Q000627:therapeutic use*; D005960:Glucosides / Q000008:administration & dosage / Q000627:therapeutic use*; D006027:Glycosides / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D057888:Iridoid Glucosides; D039823:Iridoids; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012313:RNA / Q000096:biosynthesis
D000546:Amanitins; D000931:Antidotes; D005960:Glucosides; D006027:Glycosides; D057888:Iridoid Glucosides; D039823:Iridoids; C006650:aucubin; D012313:RNA