Specific stimulation of human T lymphocytes by substance P.
Substance P (SP) and SP(4-11) stimulated significantly the proliferation of human T lymphocytes in vitro at respective concentrations of 10(-11) M to 10(-7) M and 10(-9) M to 10(-7) M, as assessed by the uptake of [3H]thymidine and [3H]leucine. The proliferative response of human T lymphocytes to PHA was augmented by 10(-9) M to 10(-8) M SP and 10(-10) M to 10(-7) M SP(4-11). The inactive analogue [D-Pro2, D-Phe7, D-Trp9]-SP inhibited the effects of SP on T lymphocytes. The specific stimulation of T lymphocytes by SP suggests a unique mechanism for the regulation of immunologic responses by peripheral nerve-derived factors.
D001798:Blood Proteins / Q000096:biosynthesis; D004247:DNA / Q000096:biosynthesis; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D008213:Lymphocyte Activation; D010446:Peptide Fragments / Q000502:physiology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013373:Substance P / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D001798:Blood Proteins; D010446:Peptide Fragments; D010835:Phytohemagglutinins; D013373:Substance P; C032682:substance P (4-11); D004247:DNA