title: Assay of comedolytic activity in acne patients.
abstract: Comedolytic activity was assessed in acne patients by determining the reduction in facial microcomedones using the cyanoacrylate follicular biopsy technique. Microcomedones were counted in five-em squares after 8 to 12 weeks of treatment. Only salicylic acid and tretinoin among seven conventional anti-acne medications were found to possess comedolytic activity. The latter was the more effective.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D001706:Biopsy; D003487:Cyanoacrylates / Q000494:pharmacology; D005260:Female; D006197:Hair / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D012459:Salicylates / Q000494:pharmacology* / Q000627:therapeutic use; D014212:Tretinoin / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D003487:Cyanoacrylates; D012459:Salicylates; D014212:Tretinoin