Analysis of brain indoleamines and catecholamines associated with burn-induced anorexia.
Guinea pigs subjected to a full-thickness 30% body surface flame burn significantly reduced food intake and lost weight for 5 days thereafter. Comparison of brain monoamine changes in burned, pair-fed control, and freely feeding control groups revealed normal levels of norepinephrine and elevated concentrations of dopamine in burned animals compared to the pair-fed control group. Levels of the serotonin precursor, tryptophan, and metabolite, 5-hydroxyindoleacetic acid, were also increased in burned compared to pair-fed animals, suggesting increased activity of indoleamine neurons. Although brain catecholamine levels were not correlated with food intake, significant negative correlations between food consumption and tryptophan, serotonin, and 5-hydroxyindoleacetic acid were observed. These data suggest that aberrations in indoleamine and possible catecholamine neurotransmitter systems may be involved in the mediation of burn-induced anorexia.
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D000855:Anorexia / Q000378:metabolism*; D001835:Body Weight; D001923:Brain Chemistry; D002056:Burns / Q000150:complications* / Q000378:metabolism; D004298:Dopamine / Q000032:analysis*; D001068:Feeding and Eating Disorders / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis*; D012701:Serotonin / Q000032:analysis*; D014364:Tryptophan / Q000032:analysis
D000596:Amino Acids; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D004298:Dopamine; D009638:Norepinephrine