Comparison of Ulex europaeus I lectin and factor VIII-related antigen in vascular lesions.
Factor VIII-related antigen (FVIIIR:Ag) has been widely used as a marker for endothelial cells. Recent studies have shown that Ulex europaeus agglutinin I lectin (UEAI) also binds specific endothelial cells. To determine the relative utility of the two endothelial cell markers, a group of vascular and nonvascular tumors were studied with both markers, using an immunoperoxidase method. Our results indicate that UEAI is a more sensitive marker for endothelial cells than FVIIIR:Ag, and that it should be used as an additional diagnostic marker for endothelial cell-derivated tumors.
D000941:Antigens / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis*; D004727:Endothelium / Q000166:cytology; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D037102:Lectins / Q000032:analysis*; D009383:Neoplasms, Vascular Tissue / Q000175:diagnosis* / Q000276:immunology; D037121:Plant Lectins; D013194:Staining and Labeling; D014841:von Willebrand Factor / Q000032:analysis*
D000941:Antigens; D001779:Blood Coagulation Factors; D037102:Lectins; D037121:Plant Lectins; C036850:Ulex europaeus lectins; D014841:von Willebrand Factor; D005169:Factor VIII