Inflammatory peptide in spinal cord: evidence that the mediator of antidromic vasodilatation is not substance P.
Extracts from rat and bovine spinal cord were found to have 300-1000 times more cutaneous oedema-inducing activity than could be attributed to their substance P-like activity estimated by assay on guinea-pig ileum. The activity on both assay systems was reduced in cord extracts from rats pretreated as neonates with capsaicin. Results of assays of fractions obtained from gel-filtration chromatography indicated that an agent, in the molecular size range for peptides, was present in spinal cord extracts, which possessed some of the properties of substance P but was not identical to it.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001681:Biological Assay; D002211:Capsaicin / Q000494:pharmacology; D002417:Cattle; D004487:Edema; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013373:Substance P / Q000494:pharmacology / Q000502:physiology; D014664:Vasodilation
D010455:Peptides; D013373:Substance P; D002211:Capsaicin