Influence of substance P and fragments on passive avoidance behavior.
N-terminal and C-terminal fragments of substance P (SP) have been shown to exert opposite effects on antinociception, grooming and fighting in mice. The present experiments explored whether these findings could be generalized to passive avoidance behavior. Substance P (SP-(1-11] and the C-terminal fragment pyroglutamyl-SP-(7-11) attenuated passive avoidance behavior when picogram amounts were injected into the nucleus accumbens. In contrast, the N-terminal fragment SP-(1-7) had an opposite effect and facilitated passive avoidance behavior.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D013373:Substance P / Q000494:pharmacology* / Q000031:analogs & derivatives
D009842:Oligopeptides; D010446:Peptide Fragments; D013373:Substance P; C026238:substance P (6-11), pGlu(6)-; C036877:substance P (1-7); D011761:Pyrrolidonecarboxylic Acid