[Destroying of antigenicity and influencing the immunochemical reactivity of hepatitis B virus antigens (HBsAg, HBcAg and HBeAg) through disinfectants--a proposed method for testing (author's transl)].
So far, hepatitis B virus cannot be grown in tissue cultures. Consequently, the inactivating effect of disinfectants upon the infectivity of hepatitis B virus could only be insufficiently investigated. Investigations using the only suitable test animal, the chimpanzee, are associated with substantial efforts and high cost and are also limited in their extent. A relatively simple and probably reliable method as test model for disinfectants used in hepatitis B prophylaxis is outlined: the destruction of the antigenicity and the decrease in the immunochemical reactivity of hepatitis B virus antigens (HBsAg, HBcAg and HBeAg). Effects of one alcoholic antiseptic and two peracetic acid containing disinfectants are investigated.
D000818:Animals; D000936:Antigen-Antibody Complex; D004202:Disinfectants / Q000494:pharmacology*; D000939:Epitopes / Q000032:analysis*; D006511:Hepatitis B Antigens / Q000276:immunology*; D006512:Hepatitis B Core Antigens / Q000276:immunology* / Q000302:isolation & purification; D006514:Hepatitis B Surface Antigens / Q000276:immunology* / Q000302:isolation & purification; D006513:Hepatitis B e Antigens / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D002679:Pan troglodytes; D011863:Radioimmunoassay
D000936:Antigen-Antibody Complex; D004202:Disinfectants; D000939:Epitopes; D006511:Hepatitis B Antigens; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
Zerstörung der Antigenität und Beeinflussung der immunochemischen Reaktivität von Antigenen des Hepatitis-B-Virus (HBsAg, HBcAg und HBeAg) durch Desinfektionsmittel--ein Prüfungsmodell.