Batrachotoxin blocks slow and retrograde axonal transport in vivo.
The accumulation of choline acetyltransferase (CAT) proximal to and nerve growth factor (NGF) distal to the intraneural site of tetrodotoxin (TTX) or batrachotoxin (BTX) injection in vivo was used to monitor orthograde and retrograde axonal transport. Orthograde axonal transport was blocked by BTX for up to 7-10 days while TTX had no effect. Similarly, retrograde transport of [125I]NGF was blocked by BTX and not by TTX.
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects*; D001496:Batrachotoxins / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology; D014459:Ulnar Nerve / Q000187:drug effects / Q000502:physiology
D001496:Batrachotoxins; D009414:Nerve Growth Factors; D013779:Tetrodotoxin; D002795:Choline O-Acetyltransferase