Antibacterial activity of palmitoyltuberactinamine N and di-beta-lysylcapreomycin IIA.
Palmitoyltuberactinamine N (Pal-Tua N) and di-beta-lysylcapreomycin IIA (di-beta-Lys-Cpm IIA), which are synthetic derivatives of the antituberculous agent tuberactinomycin (Tum) and capreomycin (Cpm) respectively, were tested for anti-bacterial activity. Pal-Tua N inhibited not only tuberactinomycin-resistant Mycobacterium smegmatis but also Escherichia coli, Corynebacterium diphtheriae, Staphylococcus aureus, Streptococcus pyogenes, although it has lost activity against Mycobacterium tuberculosis. Di-beta-Lys-Cpm IIA inhibited the growth of laboratory-derived Tum-resistant M. smegmatis and M. tuberculosis as well as Tum-resistant M. tuberculosis from patients with one exceptional case.
D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001419:Bacteria / Q000187:drug effects; D002207:Capreomycin / Q000031:analogs & derivatives* / Q000633:toxicity; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004776:Enviomycin / Q000031:analogs & derivatives / Q000633:toxicity*; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D012270:Ribosomes / Q000187:drug effects; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects; D014756:Viomycin / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D002207:Capreomycin; C033359:di-beta-lysyl capreomycin IIA; C033358:palmitoyl tuberactinamine N; D012321:DNA-Directed RNA Polymerases; D004776:Enviomycin; D014756:Viomycin