Adenomatoid tumor: immunohistological features suggesting a mesothelial origin.
Four adenomatoid tumors of the epididymis were evaluated immunohistologically for the expression of intermediate filaments and endothelial cell markers, factor VIII-related antigen and binding of Ulex europaeus I-lectin (UEA I). Immunofluorescence microscopy showed a strong reaction with antikeratin but not with anti-vimentin antibodies, indicating that adenomatoid tumor cells contain epithelial but not mesenchymal type of intermediate filaments. No staining of tumor cells was seen with anti-FVIII-related antigen antibodies or with fluorochrome-coupled UEA I. The results support the mesothelial, non-endothelial origin of adenomatoid tumors.
D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis; D003599:Cytoskeleton; D004822:Epididymis; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D006801:Humans; D007633:Keratins / Q000276:immunology; D037102:Lectins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013724:Teratoma / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology; D014841:von Willebrand Factor
D000941:Antigens; D037102:Lectins; D014841:von Willebrand Factor; D007633:Keratins; D005169:Factor VIII