A suprasellar embryonal carcinoma producing alpha-fetoprotein and human chorionic gonadotropin; treated with combined chemotherapy followed by radiotherapy.
A case of primary suprasellar embryonal carcinoma that produced alpha-fetoprotein and human chorionic gonadotropin in a 12-year-old girl is reported. Partial removal of the tumor and cis-platinum-based combined chemotherapy followed by local radiotherapy resulted in a definite regression of the tumor and improvement from clinical signs and symptoms. After these treatments, the concentrations of alpha-fetoprotein and human chorionic gonadotropin in both serum and cerebrospinal fluid decreased to undetectable levels. Serum basic fetoprotein, another tumor marker, can be a tool for evaluating the clinical course following postoperative chemotherapy.
D001761:Bleomycin / Q000627:therapeutic use; D002648:Child; D006063:Chorionic Gonadotropin / Q000096:biosynthesis*; D002945:Cisplatin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D012658:Sella Turcica; D012888:Skull Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D013724:Teratoma / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D014747:Vinblastine / Q000627:therapeutic use; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin