Comparison of a conventional and an initial 2-month intensive drug regimen for treating pulmonary tuberculosis in Swaziland.
In an area where default from out-patient treatment for tuberculosis is very frequent and leads to 16% known failures on the 2SHT/16HT regimen, a 1-year follow-up study was carried out on 201 new sputum smear-positive patients who were hospitalised for the first 2 months of treatment. The first 103 patients were treated with 2SHT/10HT and the remaining 98 with 2SHRZ/10HT. In the first group 15 (17%) out of 89 traced patients were sputum-positive on a single smear after 1 year, compared with 1 (1%) out of 78 in the second group (P less than 0.001).
D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D013541:Eswatini; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011718:Pyrazinamide / Q000008:administration & dosage; D012008:Recurrence; D012293:Rifampin / Q000008:administration & dosage; D013307:Streptomycin / Q000008:administration & dosage; D013828:Thioacetazone / Q000008:administration & dosage; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D000995:Antitubercular Agents; D011718:Pyrazinamide; D013828:Thioacetazone; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin