Isoniazid effects on choreiform movement and on GABA, HVA, and 5-HIAA in CSF.
Isoniazid was administered in 4-week open trial in patients with choreiform movement. Gamma-aminobutyric acid (GABA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in CSF were measured before and after treatment. Isoniazid did not improve choreiform movement. CSF GABA levels were significantly increased after treatment, but HVA and 5-HIAA levels were not significantly altered. The findings suggest that isoniazid influenced brain GABA metabolism but did not influence dopamine and serotonin metabolism in patients with chorieform movement.
D000368:Aged; D002819:Chorea / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007538:Isoniazid / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid
D006897:Hydroxyindoleacetic Acid; D005680:gamma-Aminobutyric Acid; D007538:Isoniazid; D006719:Homovanillic Acid