Renal haemodynamics and the effect of alpha-adrenergic blockade in running and swimming splenectomized dogs.
In splenectomized dogs swimming causes a stronger vasoconstriction in the kidney than treadmill running. Renal blood flow measured by electromagnetic flow probes decreased by 10% during treadmill running and by 37% during swimming. The renal perfusion remained low during 30 min after both running and swimming. Arterial pressure increased during running and during swimming. Phenoxybenzamine, an alpha-adrenergic blocking agent, practically abolished the changes in renal perfusion induced by exercise, but not those in arterial pressure. The changes in renal blood flow and arterial pressure were stronger than those found in a previous study in non-splenectomized dogs. We conclude that in splenectomized dogs sympathetic and adrenomedullary response during exercise is increased resulting in a stronger renal vasoconstriction and a more pronounced increase in arterial pressure, than in intact dogs.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010643:Phenoxybenzamine / Q000494:pharmacology; D005082:Physical Exertion; D012079:Renal Circulation / Q000187:drug effects*; D012420:Running; D013156:Splenectomy; D013550:Swimming
D000317:Adrenergic alpha-Antagonists; D010643:Phenoxybenzamine