title: Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs.
abstract: The effects of benzalkonium chloride, chlorbutol,xylometazoline and naphazoline on the ciliary beat frequency of human adenoids and chicken embryo tracheas have been determined and compared. Chlorbutol 0.5% appeared to arrest ciliary motion in both tissues within 5 minutes. Rinsing with Locke Ringer solution (LR) restored the ciliary motion almost completely in both cases. Benzalkonium chloride 0.006% +EDTA 0.1% decreased the ciliary beat frequency 35% for the human tissues and 50% for the chicken tissues after a contact of 20 minutes. In both cases the frequency hardly changed after rinsing with LR. Naphazoline nitrate 0.1% and xylometazoline HCl 0.05% have reversible effects on the ciliary beat frequency of both human adenoids and chicken embryo tracheas. Cilia of human adenoids appeared to be more sensitive for xylometazoline than for naphazoline; whereas cilia of chicken embryo tracheas were more affected by naphazoline than by xylometazoline. The results with human adenoids and chicken embryo tracheas show a correlation (correlation coeff. = 0.82, p less than 0.005). In the initial response the differences in sensitivity to preservatives and drugs were in many cases statistically significant, but the final effects were similar.
mesh_terms: D000234:Adenoids / Q000502:physiology*; D000818:Animals; D001548:Benzalkonium Compounds / Q000494:pharmacology; D002642:Chick Embryo; D002648:Child; D002724:Chlorobutanol / Q000494:pharmacology; D002923:Cilia / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D009278:Naphazoline / Q000494:pharmacology; D014663:Nasal Decongestants / Q000494:pharmacology; D014132:Trachea / Q000502:physiology*
chemical_list: D001548:Benzalkonium Compounds; D007093:Imidazoles; D014663:Nasal Decongestants; D009278:Naphazoline; D002724:Chlorobutanol; C009695:xylometazoline