Intralesional chemotherapy for Kaposi's sarcoma.
Over a period of 36 months we treated 12 patients with skin localizations of Kaposi's sarcoma with intralesional chemotherapy. Local administration of vincristine (usual dose 0.1 mg per site) or bleomycin appeared to be very effective: in 93 injected nodules we obtained 74 complete and 19 partial regressions. No significant local or systemic toxicity has so far been observed.
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage* / Q000627:therapeutic use
D001761:Bleomycin; D014750:Vincristine