title: Ca2+-calmodulin-dependent protein kinase in neuronal nuclei.
abstract: Ca2+-calmodulin-dependent protein kinase represents a major enzyme activity in neuronal nuclei. Most of the protein kinase activity is associated with the nuclear matrix but it can phosphorylate a broad range of substrates which derive from different nuclear compartments. Notable among these substrates is a Mr = 50,000 component of the nuclear matrix and a high mobility group chromatin protein which behaves like HMG17. The high level of activity, age- and tissue-specificity, and sensitivity to low concentrations of calmodulin suggest a role for this Ca2+-calmodulin-dependent protein kinase in regulating neuronal function at the level of the nucleus.
mesh_terms: D000367:Age Factors; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D002467:Cell Nucleus / Q000201:enzymology; D002540:Cerebral Cortex / Q000166:cytology; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D006609:High Mobility Group Proteins; D008099:Liver / Q000201:enzymology; D008970:Molecular Weight; D009457:Neuroglia / Q000201:enzymology; D009474:Neurons / Q000201:enzymology* / Q000648:ultrastructure; D011494:Protein Kinases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002147:Calmodulin; D002868:Chromosomal Proteins, Non-Histone; D006609:High Mobility Group Proteins; D011494:Protein Kinases; D002118:Calcium