[Microbiological short-time tests for the evaluation of mutagenic potential of chemical substances].
During the last 20 years it became much more interesting to test new chemicals as fast as possible for their carcinogenic potency. Therefore new test models were developed. Mutagenicity seems to be one sign for carcinogenicity. Therefore test systems using microorganisms were studied which are influenced by mutagenic substances. These systems are described, first of all the Ames-Test, using revertants of Salmonella typhimurium, secondly the Escherichia coli system deficient of DNA-polymerase A (DNA-Pol A-). The yeast Saccharomyces cerevisiae was introduced some years ago and finally the Neurospora crassa system serves as an additional test to define exactly the localisation of mutations. The tests and their problems are discussed.
D004257:DNA Polymerase II / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D009491:Neurospora / Q000187:drug effects*; D009492:Neurospora crassa / Q000187:drug effects* / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
D009153:Mutagens; D004257:DNA Polymerase II
Mikrobielle Kurzzeitteste zur Bestimmung der mutagenen Potenz chemischer Substanzen.