title: New insight into lymphocytic chalone research. The 'facteur thymique Sérique' might be responsible for part of the immunosuppressive activity detected in the 'chalone fraction'.
abstract: Immunosuppressive activities have been detected in bovine spleen extracts and attributed to the presence of a 'lymphocytic chalone'. Following the immunosuppression of a T cell-dependent humoral response in mice as assay, we purified a peptide to homogeneity present at a concentration of 10-50 ng/kg of spleen whose properties were identical to those of the serum thymic factor. This factor appeared to be a regulator of the humoral immune response in the splenic extract and as such might be responsible for part of the immunosuppressive activities detected in the splenic 'chalone' fraction.
mesh_terms: D000818:Animals; D002417:Cattle; D050150:Chalones; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D006131:Growth Inhibitors / Q000032:analysis* / Q000276:immunology; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains; D010447:Peptide Hydrolases / Q000494:pharmacology; D011506:Proteins; D013154:Spleen / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D050150:Chalones; D006131:Growth Inhibitors; D011506:Proteins; C029299:chalone-T; D010447:Peptide Hydrolases