title: Phase I study of continuous venous infusion of floxuridine (5-FUDR) chemotherapy.
abstract: Floxuridine (5-FUDR) was administered by continuous venous infusion using an ambulatory portable pump in a phase I study designed to establish the optimal (maximal) daily dose rate to deliver a minimum of 14 days of drug therapy. The major determinant of toxicity was dose rate rather than cumulative dose. Patients receiving greater than 0.15 mg/kg/day developed dose-limiting diarrhea at 7-14 days (median, 10), while patients receiving 0.1-0.125 mg/kg/day were treated for 18-78 days without adverse effects. The recommended daily dose rate for continuous-infusion schedules of 14 days is 0.15 mg/kg/day.
mesh_terms: D004341:Drug Evaluation; D005467:Floxuridine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007263:Infusions, Parenteral; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D005467:Floxuridine