title: [Spasmolytic and anti-inflammatory activity of 8-hydroxyquinolines].
abstract: It has been shown that quinozole (aqueous solution), enteroseptol and nitroxoline (suspension with Tween-80) in a concentration of 0.2 X 10(-6)-1.10(-5) decrease the tone of the rat and guinea-pig ileum and diminish their peristalsis. When administered in the same concentrations quinozole removes or prevents the spasmogenic effects of barium chloride (1 X 10(-5)-4.10(-5), of histamine (2 X 10(-5) and -6) but not of acetylcholine (1 X 10(-6)). When administered orally in a dose 50 mg/kg to rats enteroseptol and nitroxoline inhibit the serotonin-, agar- and carrageenin-induced edemas of the rat paws without changing the response to subplantar injection of histamine. The data obtained should be taken into consideration during the use of 8-hydroxyquinolines as antimicrobial substances.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007464:Clioquinol / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005748:Gastric Fundus / Q000187:drug effects; D006168:Guinea Pigs; D006912:Hydroxyquinolines / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009600:Nitroquinolines / Q000494:pharmacology / Q000627:therapeutic use; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D010276:Parasympatholytics / Q000494:pharmacology*; D010528:Peristalsis / Q000187:drug effects; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D006912:Hydroxyquinolines; D009600:Nitroquinolines; D010276:Parasympatholytics; D015125:Oxyquinoline; D007464:Clioquinol; C005308:nitroxoline
vernacular_title: Spazmoliticheskaia i protivovospalitel'naia aktivnost' 8-oksikhinolinov.