Autologous mixed lymphocyte reaction in health and disease states in man.
In this review are discussed the nature of T cell subsets, defined with monoclonal antibodies, responding in T-non-T and T-T autologous mixed-lymphocyte reactions (AMLR) and antigens stimulating in AMLR, soluble products of AMLR and generation of suppressor, helper and cytotoxic functions. On the basis of these data a model of immunoregulation in vivo can be proposed. We believe that AMLR is a real-phenomenon and not an artefact and perhaps represents a mechanism by which various immune functions are regulated, including feedback regulation of AMLR. The significance of AMLR is further supported by studies in various human and animal diseases.
D000328:Adult; D000368:Aged; D000375:Aging; D000911:Antibodies, Monoclonal / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D003920:Diabetes Mellitus / Q000276:immunology; D004314:Down Syndrome / Q000276:immunology; D005260:Female; D000949:Histocompatibility Antigens Class II; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007109:Immunity; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D007244:Infectious Mononucleosis / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000276:immunology; D008105:Liver Cirrhosis, Biliary / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000276:immunology; D012397:Rosette Formation; D012507:Sarcoidosis / Q000276:immunology; D012859:Sjogren's Syndrome / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II