Destruction of microsomal cytochrome P-450 by reactive oxygen species generated during photosensitization of hematoporphyrin derivative.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000494:pharmacology*; D008027:Light; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010100:Oxygen; D010782:Photolysis; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D026082:Singlet Oxygen
D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; D026082:Singlet Oxygen; D017324:Hematoporphyrin Derivative; D003577:Cytochrome P-450 Enzyme System; D010100:Oxygen