Steroid hormones and embryo development in ovariectomized hamsters.
Preimplantation embryo development was arrested at the premorula stage in hamsters ovariectomized on Day 1 of pregnancy. This effect was reversed when 500 micrograms progesterone were administered daily. Oestradiol-17 beta given alone had no significant effect on the cleavage rate or blastocyst formation, but a synergistic response was evident when a suboptimal (30 micrograms) dose of progesterone was given with 50 ng oestradiol-17 beta. Cholesterol and hydrocortisol had no effect on embryo development.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects*; D002369:Castration; D002784:Cholesterol / Q000494:pharmacology; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D008525:Medroxyprogesterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D008647:Mesocricetus; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*
D011374:Progesterone; D004958:Estradiol; D002784:Cholesterol; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D006854:Hydrocortisone