Lymphocyte populations and responses to mitogens in infants of diabetic mothers.
A group of 10 infants of diabetic mothers, born prematurely by Caesarian section was compared to an age-matched group of premature controls and to full-term newborns. There was no difference between the three groups in terms of lymphocyte populations at birth. The percentage of T-cells in the three groups was significantly lower than in adults but reached adult levels at 1 month of age. The mitogenic responses in infants of diabetic mothers was found significantly higher than in the two control groups at birth and remained so at one month of age. The suppressor T-cell activity was decreased in infants of diabetic mothers as compared with controls.
D001402:B-Lymphocytes / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D007111:Immunity, Cellular; D007231:Infant, Newborn; D007234:Infant, Premature; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification* / Q000276:immunology; D008934:Mitogens / Q000494:pharmacology*; D011247:Pregnancy; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D008934:Mitogens