[Effect of synthetic beta-carotene on the formation of cytolytic T-lymphocytes].
The effect of intraperitoneal injection of beta-carotene in different doses on the formation of cytolytic T lymphocytes (CTL) in a one-way mixed lymphocyte culture (MLC) of allogeneic mice was studied. The maximal cytotoxic activity of lymphocytes was attained in the MLC with splenocytes of mice which received 10 mg/kg beta-carotene 6 days before experimentation. The correlation was studied between the beta-carotene ability to stimulate CTL formation and antineoplastic activity. It was discovered that injection of beta-carotene in doses and times provoking maximal CTL induction had no effect on the animals' lifespan and the size of transplanted sarcoma 180.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002338:Carotenoids / Q000494:pharmacology* / Q000627:therapeutic use; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000188:drug therapy; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D019207:beta Carotene
D000970:Antineoplastic Agents; D019207:beta Carotene; D002338:Carotenoids
Vliianie sinteticheskogo beta-karotina na obrazovanie tsitoliticheskikh T-limfotsitov.