[Acute anuric hemolysis caused by antiajmaline antibodies].
In a 32-year old woman under ajmaline therapy for cardiac arrhythmia, a sudden episode of acute haemolytic anaemia and renal failure led to the identification of a potent agglutinating, haemolysing and lymphocytotoxic antibody specific to ajmaline and cross-reacting with quinine and quinidine. The immunological features of the antibody and the pathophysiological mechanism of blood cell destruction are presented, together with a brief synopsis of drugs incriminated so far in the induction of specific antibody formation and immune haemolytic anaemia.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000404:Ajmaline / Q000009:adverse effects* / Q000276:immunology; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000906:Antibodies / Q000032:analysis; D003602:Cytotoxicity, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans
D000906:Antibodies; D000404:Ajmaline
Hémolyse aiguë anurique par anticorps anti-ajmaline.