Fenbendazole as a therapy for naturally acquired Stephanurus dentatus and gastrointestinal nematodes in feral swine.
Adult feral swine, naturally infected with kidney worms (Stephanurus dentatus) and gastrointestinal nematodes, were divided into two groups of 10 pigs each. One group was treated with fenbendazole (Panacur, Hoechst AG, Frankfurt am. Main) mixed in feed at the rate of 3 mg kg-1 body weight for 3 days. The second group received feed only and was designated as non-treated controls. The animals in both groups were necropsied 3 weeks post-treatment and examined for the presence of live and dead adult kidney worms in the perirenal and ureteral area, ureteral penetration, the presence of kidney worm larvae in the liver, hepatic scars due to kidney worm larval migration, and for liver fibrosis. No live adult kidney worms were found in the perirenal and ureteral areas of treated pigs, and the non-treated pigs harbored an average of 42.8 live worms. No liver kidney worm larvae were found in the livers of treated pigs, and the non-treated pigs averaged 6.7 live larvae. At necropsy, urine samples from 8 of the 10 treated pigs contained no kidney worm eggs, and only 2 eggs were found in samples from each of the remaining 2 pigs in this group. In contrast, urine samples from 8 of the non-treated pigs contained numerous kidney worm eggs. Reductions in ascarid (Ascaris suum) and nodular worm (Oesophagostomum dentatum) egg counts were also observed in treated pigs.
D000818:Animals; D000835:Animals, Wild; D001200:Ascaris; D001562:Benzimidazoles / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000627:therapeutic use*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D009348:Nematoda; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009815:Oesophagostomum; D010270:Parasite Egg Count / Q000662:veterinary; D017206:Strongylida Infections / Q000188:drug therapy / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*
D001562:Benzimidazoles; D005273:Fenbendazole