Circulating factors affect 6-phosphofructokinase activity in human adipose tissue.
6-Phosphofructokinase activity was lower in adipose tissue of obese, insulin-resistant subjects studied at stable body weight than in nonobese controls. This difference was absent during weight loss due to an increase in 6-phosphofructokinase activity in the obese subjects; the change suggested possible regulation by circulating factors. In an initial test of this hypothesis, blood serum collected from obese subjects at stable weight and incubated with adipose tissue in vitro produced lower 6-phosphofructokinase activity than did sera from nonobese controls.
D000273:Adipose Tissue / Q000201:enzymology*; D000293:Adolescent; D000328:Adult; D004032:Diet; D004038:Diet, Reducing; D005947:Glucose / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007333:Insulin Resistance; D007700:Kinetics; D009765:Obesity / Q000097:blood / Q000201:enzymology; D010732:Phosphofructokinase-1 / Q000378:metabolism*
D010732:Phosphofructokinase-1; D005947:Glucose