The effect of irradiation on the development of low-dose streptozotocin diabetes in mice.
The effect of single-dose whole-body irradiation (6.0 Gy) on the development of low-dose streptozotocin diabetes in male C57 Bl/KsJ-mice was investigated. When irradiation precedes the SZ application the development of hyperglycemia could be prevented. Irradiation after SZ injections at the time of appearance hyperglycemia did not interfere with the onset of diabetes. The results underline the participation of radiosensitive immune cells as an etiologic factor of low-dose SZ diabetes.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000276:immunology*; D005720:Gamma Rays; D007111:Immunity, Cellular / Q000528:radiation effects*; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D007962:Leukocytes / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013311:Streptozocin
D013311:Streptozocin