Skin irritation by dithranol (anthralin) and its 10-acyl analogues in 3 animal models.
The skin irritant properties of a single application of dithranol (anthralin), a typical "delayed irritant", and its 10-acyl analogues in acetone or white petrolatum were compared in 3 animals models. Maximal irritation was reached at about 24 h in mouse ear, 48 h in guinea pig back and 1 week in miniature swine back, the last-mentioned serving as a good model of human skin. In all animal species, butantrone was significantly less irritant than dithranol, 10-acetyl dithranol or 10-propionyl dithranol. 10-acetyl dithranol was the most irritant compound. Clinical trials with butantrone on psoriasis are justified.
D000818:Animals; D000873:Anthracenes / Q000633:toxicity*; D000875:Anthralin / Q000031:analogs & derivatives / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D013552:Swine; D013556:Swine, Miniature
D000873:Anthracenes; C038464:butantrone; D000875:Anthralin