Effect of marine glycosides on adenosinetriphosphatase activity.
Marine glycosides from the sea cucumbers Actinopyga agassizi, Holothuria atra, Bohadschia argus, Cucumaria fraudatrix, Astichopus multifidus and Thelenota ananas inhibit both Na+-K+ ATPase and Mg2+-ATPase of rat brain in vitro. The glycoside-cholesterol complex of these compounds does not influence ATPase activity. Asterosaponins from starfishes Linckia guildingi and Linckia laevigata possess a slight inhibiting effect. The triterpene glycosides from sea cucumbers are more powerful inhibitors than steroidal glycosides from starfishes.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000201:enzymology; D006027:Glycosides / Q000494:pharmacology*; D066298:In Vitro Techniques; D008387:Marine Toxins / Q000494:pharmacology*; D008861:Microsomes / Q000201:enzymology; D051381:Rats; D012616:Sea Cucumbers; D013215:Starfish; D013329:Structure-Activity Relationship
D006027:Glycosides; D008387:Marine Toxins; D000251:Adenosine Triphosphatases