Interaction of cyproterone acetate with sex hormone binding globulin of monkey plasma.
Cyproterone acetate (CA), an antiandrogen, has been used clinically for treatment of hirsute women. In vitro competitive binding assay has revealed that CA displaces estradiol selectively from sex hormone binding globulin (SHBG) of female monkey plasma.
D000726:Androgen Antagonists / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000378:metabolism; D017373:Cyproterone Acetate; D013196:Dihydrotestosterone / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006854:Hydrocortisone / Q000378:metabolism; D008253:Macaca mulatta; D011374:Progesterone / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism
D000726:Androgen Antagonists; D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D013739:Testosterone; D011374:Progesterone; D017373:Cyproterone Acetate; D004958:Estradiol; D003534:Cyproterone; D006854:Hydrocortisone