Effects of diiospropyl-1,3-dithiol-2-ylidene malonate (NKK-105) on acute toxicity of various drugs and heavy metals.
The influence of NKK-105 on the acute toxicity of strychnine nitrate, potassium cyanide, chloral hydrate, atropine, tetrodotoxin, mercuric chloride, cadmium chloride, lead acetate and arsenic trioxide were examined in rats. NKK-105 prolonged the time of death induced by strychnine, potassium cyanide and tetrodotoxin in acute toxicity. Survival time was prolonged in rats treated with the toxic metals by pretreatment with NKK-105. NKK-105 counteracted the lethal effect of strychnine, potassium cyanide, chloral hydrate, mercuric chloride and cadmium chloride. NKK-105 significantly decreased the acute toxicity of these drugs but the inhibitory effect was not observed in the acute toxicity of atropine, tetrodotoxin, lead acetate and arsenic trioxide.
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D001151:Arsenic / Q000633:toxicity; D000077237:Arsenic Trioxide; D001152:Arsenicals; D001285:Atropine / Q000633:toxicity; D002104:Cadmium / Q000633:toxicity; D002697:Chloral Hydrate / Q000633:toxicity; D007854:Lead / Q000633:toxicity; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D008627:Mercuric Chloride; D008628:Mercury / Q000633:toxicity; D008670:Metals / Q000633:toxicity*; D010087:Oxides; D011190:Potassium Cyanide / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013331:Strychnine / Q000633:toxicity; D013779:Tetrodotoxin / Q000633:toxicity
D000931:Antidotes; D001152:Arsenicals; D008314:Malonates; D008670:Metals; D010087:Oxides; D002104:Cadmium; D007854:Lead; D002697:Chloral Hydrate; D013779:Tetrodotoxin; D008627:Mercuric Chloride; D001285:Atropine; D008628:Mercury; D013331:Strychnine; D011190:Potassium Cyanide; D001151:Arsenic; C024808:diisopropyl 1,3-dithiol-2-ylidenemalonate; D000077237:Arsenic Trioxide