Increased number of high-affinity muscarinic receptors in rat heart after phenylhydrazine treatment.
The effect of phenylhydrazine-induced heart hypertrophy on muscarinic cholinergic binding sites was studied in heart membranes by determining total (with [3H]NMS) and high-affinity (with [3H]Oxo-M) binding sites and estimating low-affinity binding sites by difference. Phenylhydrazine induced an increased concentration of high-affinity binding sites without affecting the concentration of low-affinity binding sites. The KD values for the ligands were unaffected.
D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000032:analysis*; D010659:Phenylhydrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000032:analysis* / Q000187:drug effects
D010659:Phenylhydrazines; D011976:Receptors, Muscarinic