[Suppressor activity changes in human T-lymphocytes as affected by adreno- and cholinotropic substances].
The influence of oxyfedrine (beta-adrenoagonist) and carbocholine (cholinoagonist) on the functional activity of Con A-induced suppressor T-lymphocytes in healthy persons and in bronchial asthma patients was studied. Oxyfedrine at a concentration of 10 micrograms/ml (10(-5) M) was shown to induce a significant increase in the suppressing activity of both normal lymphocytes and those obtained from bronchial asthma patients. The repeated incubation of lymphocytes with carbocholine at a concentration of 5 micrograms/ml (10(-6) M) led to the removal of the suppressing effect of normal lymphocytes and to the increase of the activating effect of lymphocytes from bronchiae asthma patients.
D001249:Asthma / Q000276:immunology; D002217:Carbachol / Q000276:immunology*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D010099:Oxyfedrine / Q000276:immunology*; D011427:Propiophenones / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology
D011427:Propiophenones; D003208:Concanavalin A; D002217:Carbachol; D010099:Oxyfedrine
Izmenenie supressornoĭ aktivnosti T-limfotsitov cheloveka pod vliianiem adrenokholinotropnykh veshchestv.