Changes in lysosomal enzyme activities in exercise-induced cardiac hypertrophy of mice.
The activities of several lysosomal enzymes were assayed in control and in exercise-hypertrophied cardiac muscle of mice (Mus musculus). The repeated running program increased the activity of beta-glucuronidase (16.1%) in mouse cardiac muscle. Decreased activities of beta-N-acetylglucosaminidase (10.8%), acid ribonuclease (10.7%), and arylsulphatase (14.2%) were observed in the hypertrophied myocardium. The activities of acid deoxyribonuclease, cathepsin C, cathepsin D, and p-nitrophenylphosphatase as well as the activities of citrate synthase and cytochrome c oxidase, mitochondrial enzymes, were unaffected in cardiac muscle. We suggest that lysosomal enzyme responses are selective and highly different in physiologically and pathologically induced cardiac hypertrophies.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D006332:Cardiomegaly / Q000201:enzymology*; D005966:Glucuronidase / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051379:Mice; D009206:Myocardium / Q000201:enzymology*; D005082:Physical Exertion; D012260:Ribonucleases / Q000378:metabolism
D012260:Ribonucleases; D001192:Arylsulfatases; D005966:Glucuronidase; D000118:Acetylglucosaminidase