N,N-disubstituted 2-aminotetralins are potent D-2 dopamine receptor agonists.
Mono- and di-N-substituted 2-amino-5-hydroxytetralins stimulate the D-2 dopamine receptor, 2-(N-n-propyl-N-phenylethylamino)-5-hydroxytetralin being the most potent D-2 agonist encountered to date. In contrast, 2-amino-5-hydroxytetralins only marginally stimulate the D-1 receptor; however, 2-(di-N-n-propylamino)-5, 6-dihydroxytetralin is equipotent with dopamine as a D-1 agonist. The results are discussed within the context of the two dopamine receptor hypothesis.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D005576:Colforsin; D004224:Diterpenes / Q000494:pharmacology; D006054:Goldfish; D066298:In Vitro Techniques; D009281:Naphthalenes / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2; D012160:Retina / Q000201:enzymology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D001549:Benzamides; D004224:Diterpenes; D009281:Naphthalenes; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D013764:Tetrahydronaphthalenes; D005576:Colforsin; D011388:Prolactin; D000262:Adenylyl Cyclases; C030265:nemonapride