title: Nicorandil attenuates myocardial acidosis during coronary occlusion in dogs.
abstract: In dogs anaesthetized with pentobarbitone, the left anterior descending coronary artery (LAD) was partially occluded. Before and 30 min after partial occlusion, the myocardial pH was 7.52-7.54 and 6.89-6.91, respectively. Nicorandil (50 micrograms kg-1, i.v.) increased the pH that had been reduced by partial occlusion and this effect lasted at least 60 min. Thus nicorandil attenuates ischaemic myocardial acidosis.
mesh_terms: D000138:Acidosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000818:Animals; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D004285:Dogs; D005260:Female; D006331:Heart Diseases / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020108:Nicorandil; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D009536:Niacinamide; D020108:Nicorandil