title: [Resistance of enterobacteria to the sulfonamide-trimethoprim combination. Course during the last 10 years].
abstract: From january 1972 to december 1981, nearly 54.000 strains of enterobacteria isolated from clinical specimens were tested for susceptibility to the trimethoprim-sulfamide combination (co-trimoxazole). During that period, the overall resistance to trimethoprim increased from 17.9% to 32.7%, and there was a fourfold increase in the number of strains exhibiting high level resistance; 246 trimethoprim-resistant plasmids were transferred into E. coli K 12. The number and frequency of the other resistance markers co-transferred with trimethoprim are constantly increasing and as a result, more and more antibiotics are likely to be responsible for the selection of trimethoprim-resistant plasmids. In contrast, the proportion of trimethoprim-resistant mutants decreased from 11% to 5%. The use of co-trimoxazole in France may explain this low incidence.
mesh_terms: D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013449:Sulfonamides / Q000494:pharmacology*; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: D013449:Sulfonamides; D014295:Trimethoprim
vernacular_title: Résistance des entérobactéries à l'association sulfamide + triméthoprime. Evolution au cours des 10 dernières années.