title: Failure of malaria vaccination in mice born to immune mothers. II. Induction of specific suppressor cells by maternal IgG.
abstract: Female BALB/c mice were vaccinated against blood stage P. yoelii malaria, infected 2 weeks later and after recovery mated to C57B1/6 males. When their offspring were subsequently vaccinated, the effectiveness of vaccination, as assessed by survival after infection, was significantly impaired until 8 weeks of age. Cell and serum transfer experiments indicated that specific maternally derived IgG interferes with protection in two distinct ways: (1) directly by prevention of priming by the vaccine and (2) indirectly by the induction and maintenance of specific suppressor T cells (TS) which act to inhibit the generation of memory T helper cells involved in IgG production, as measured by the response to TNP-P. yoelii. Furthermore, it is shown that the maternal IgG and the TS cells act in synergy to abolish the protective effect of vaccination.
mesh_terms: D000375:Aging; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000918:Antibody Specificity; D005260:Female; D006462:Hemolytic Plaque Technique; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000276:immunology*; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014611:Vaccination
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G