The pharmacokinetics and tissue penetration of norfloxacin.
The pharmacokinetics and cantharides-induced blister fluid levels of norfloxacin were studied after a single 400 mg oral dose. The mean maximum serum level was 1.45 mg/l and occurred 1.5 h after administration. The serum half-life of norfloxacin was found to be 3.5 h. After 24 h 27% of the administered dose was recovered in the urine as microbiologically active compound. High urine levels were found. Rapid blister fluid penetration occurred, the maximum level (occurring between 2-3 h) was about 1 mg/l. Thereafter the blister fluid level exceeded the serum level, both declining in parallel.
D000328:Adult; D000890:Anti-Infective Agents / Q000097:blood / Q000378:metabolism*; D001768:Blister / Q000378:metabolism; D002193:Cantharidin / Q000494:pharmacology; D005122:Exudates and Transudates / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D009268:Nalidixic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D009643:Norfloxacin
D000890:Anti-Infective Agents; D009268:Nalidixic Acid; D002193:Cantharidin; D009643:Norfloxacin