[Effect of ketanserin on various properties of pentobarbital in rats].
Rats pre-treated with the quinazoline-dione derivative Ketanserin (1,25, 2,5 and 5 mg.kg-1, i.p.) (Janssen Pharmaceutica, Beerse, Belgium) present a more prolonged general anaesthesia and a more pronounced incapacity to stand up when injected with pentobarbital (30 to 120 mg.kg-1, i.p.). Cold shivering linked to Ketanserin is also suppressed.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004347:Drug Interactions; D007650:Ketanserin; D010424:Pentobarbital / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D010880:Piperidines; D007650:Ketanserin; D010424:Pentobarbital
Action de la kétansérine sur quelques propriétés du pentobarbital chez le rat.