[Possibility of correcting brain bioenergetics in neuroses using nicotinic acid derivatives].
Experiments were made to study the effect of the animals' neurosis status on the synthesis of macroergs according to the oxidative phosphorylation data and macroerg utilization via the ATPase system. It was demonstrated that in the stage of metabolic deadaptation , neurosis leads to dramatic inhibition of oxidative phosphorylation and its dissociation, decreases the content of macroergs , discoordinates the ATPase system. The prophylactic administration of nicotinic acid derivatives stimulated oxidative phosphorylation, making return to normal the content of macroergs and the ATPase activity. According to some data, the action of chlorodiazepoxide aggravated adverse effects of neurosis. The possibility of correcting brain bioenergetics with nicotinic acid derivatives has been shown.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D008032:Limbic System / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism; D009539:Nicotinic Acids / Q000627:therapeutic use*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats
D009539:Nicotinic Acids; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; C041554:litonit; C041555:nikogamol; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases
O vozmozhnosti korrektsii bioénergetiki mozga proizvodnymi nikotinovoĭ kisloty pri nevrozakh.