The swift increase in alcohol metabolism.
Gastric intubation of female Sprague-Dawley rats with 5 g of ethanol/kg body wt doubled oxygen and ethanol uptake by the isolated perfused rat liver after only 2-5 h of treatment (Swift Increase in Alcohol Metabolism). Diminished ATP generation via glycolysis accounts for a portion of the increased oxygen uptake. These data indicate that at least part of the stimulated oxygen uptake after treatment with ethanol is a result of lower rates of glycolytic ATP generation resulting from hormone action. The ADP not phosphorylated in the cytocol enters the mitochondrion where it stimulates oxygen uptake.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009243:NAD; D000431:Ethanol; D000244:Adenosine Diphosphate; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; D000251:Adenosine Triphosphatases