title: The use of Neurospora in the evaluation of the mutagenic activity of environmental chemicals.
abstract: The utility of various assay systems developed with Neurospora for hazard identification, hazard evaluation, and risk estimation is discussed. The use of the ad-3 test system in a two-component heterokaryon is discussed in relation to its utility for hazard evaluation and risk estimation. This ad-3 assay provides information on those specific locus mutations that arise by multilocus deletions with regard to both frequency and relative size. Information on this class of specific locus mutations is particularly important because, as shown in Drosophila, mouse, and man, this type of damage can have immediate and undesirable effects on F1 progeny.
mesh_terms: D000818:Animals; D002872:Chromosome Deletion; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000235:genetics; D004787:Environmental Pollution; D005260:Female; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D009491:Neurospora / Q000187:drug effects*; D009492:Neurospora crassa / Q000187:drug effects* / Q000235:genetics; D012306:Risk; D014960:X Chromosome
chemical_list: D009153:Mutagens