Effects of selective dopamine D2-receptor agonists on the release of cholecystokinin-like immunoreactivity from rat neostriatum.
It was investigated whether or not the release of cholecystokinin-like immunoreactivity from slices of rat caudatoputamen could be modulated via dopamine D2-receptors. The release of immunoreactivity was stimulated by high concentrations of K+ (35 to 55 mM). The effects of two D2-selective dopaminergic agonists, RU 24926 and LY 141865, were tested on the K+-induced release. Both agents enhanced the release of immunoreactivity in a concentration-dependent manner. The effect of RU 24926 was blocked by (-)-sulpiride and domperidone, two selective D2-antagonists. It is concluded that stimulation of dopamine receptors of the D2-subtype enhances the release of cholecystokinin-like immunoreactivity from nerve endings in rat neostriatum.
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism*; D004294:Domperidone / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D010627:Phenethylamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011699:Putamen / Q000187:drug effects* / Q000378:metabolism; D019257:Quinpirole; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2; D013469:Sulpiride / Q000494:pharmacology
D004873:Ergolines; D010627:Phenethylamines; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D004294:Domperidone; C025254:RU 24926; D013469:Sulpiride; D002766:Cholecystokinin; D011188:Potassium