[Intragastric administration of norartrinal in hemorrhage caused by rupture of esophageal varices].
In 20 patients with g hepatic cirrhosis hospitalized for upper digestive haemorrhage by rupture of oesophageal varices, the intragastric administration of norartrinal in amounts of 4-40 mg/24 h achieved definitive haemostasis in 7 cases and temporary haemostasis (with prolonged survival) in another 6 cases. The overall mortality was 80%. In three of the 7 patients in which haemorrhage was completely arrested death occurred as a result of hepatic failure. The large amounts of Norartrinal administered (up to 120 mg total dose) were well tolerated and did not have haemodynamic side-effects, or renal side-effects. The results obtained, and especially the easy method used for administration of the drug recommend this method as an alternative of the vasopressin treatment.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D004932:Esophageal and Gastric Varices / Q000150:complications* / Q000209:etiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007263:Infusions, Parenteral; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000008:administration & dosage*; D012421:Rupture
D009638:Norepinephrine
Administrarea intragastrică de norartrinal in hemoragiile prin ruptura varicelor esofagiene.