Serum zinc and vitamin E concentrations in handicapped children treated with anticonvulsants.
Serum zinc and vitamin E concentrations were measured in handicapped children aged 4-17 years, treated (n = 32) and untreated (n = 13) with phenytoin and phenobarbital. The mean serum zinc levels were 81 +/- 16 and 82 +/- 7 micrograms/dl in the treated and untreated children, respectively. The difference was not significant between these two groups. Hypozincnemia (below 70 micrograms/dl), however, was found in 7 of the 32 treated patients and in none of the 13 untreated children. The serum vitamin E level was 0.58 +/- 0.18 mg/dl in the treated and 0.67 +/- 0.17 mg/dl in the untreated children, indicating significantly lower levels in the treated patients (p less than 0.005). A significant positive correlation was found between the serum zinc and vitamin E levels (r = 0.45, p less than 0.005). Thus, long-term use of anticonvulsants results in a vitamin E and zinc deficiency, which may produce several unfavorable problems in children.
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D006233:Persons with Disabilities; D006801:Humans; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D014810:Vitamin E / Q000097:blood*; D015032:Zinc / Q000097:blood*
D000927:Anticonvulsants; D014810:Vitamin E; D010672:Phenytoin; D015032:Zinc; D010634:Phenobarbital