Induction of mutations by 5-fluorodeoxyuridine: a mechanism of self-potentiated drug resistance?
In medium containing concentrations of deoxycytidine that occur in vivo, 5-fluorodeoxyuridine induced mutation frequencies 6-90 fold greater than spontaneous mutant frequencies at two genetic loci in Chinese hamster cells. In medium lacking deoxycytidine, 5-fluorodeoxyuridine was more cytotoxic but induced no mutants. Hence, the effectiveness of cancer therapy with 5-fluorodeoxyuridine may be limited by self potentiated development of 5-fluorodeoxyuridine-resistant mutants and enhanced and prolonged by manipulating deoxycytidine metabolism.
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003841:Deoxycytidine / Q000494:pharmacology; D004351:Drug Resistance; D005467:Floxuridine / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens
D009153:Mutagens; D005467:Floxuridine; D003841:Deoxycytidine