Influence of ipratropiumbromide on heart rate and hemodynamics in patients with sinus bradycardia.
In 13 patients with sinus bradycardia, heart rate and hemodynamics were recorded before and 3, 30, 60, and 120 minutes following intravenous administration of 0.5 mg ipratropiumbromide (Itrop by C. H. Boehringer Sohn, Ingelheim, West Germany). Heart rate already started to rise during the injection of ipratropiumbromide. It increased by an average of 78% three minutes following the administration as compared to pretreatment control values. Mean heart rate still was markedly increased by an average of 26% at 120 min following the injection of the drug. This effect of ipratropiumbromide on heart rate was accompanied by an increase in cardiac index while stroke volume decreased due to a decrease in ejection fraction and diastolic filling time.
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001286:Atropine Derivatives / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000188:drug therapy*; D002302:Cardiac Output / Q000187:drug effects; D004341:Drug Evaluation; D005260:Female; D005263:Femoral Artery / Q000502:physiology; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D009241:Ipratropium / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000502:physiology; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D001286:Atropine Derivatives; D009241:Ipratropium