[Intravenous administration of plasmin-treated immunoglobulins. A 2-year study in 16 patients with humoral deficiency].
The immunological and clinical results of a 2-year study of 16 patients with agammaglobulinaemia (common variable in 12 and sex-linked in 4) are reported. Plasmin-treated immunoglobulins were injected at 3 weeks' intervals during the first part of the trial and at 2 weeks' interval during the second part. An increase in serum IgG levels was observed after 24 hours and 7 days, with progressive return to initial values on the 14th day. Twelve patients showed signs of clinical improvement.
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000276:immunology / Q000628:therapy*; D000917:Antibody Formation; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D005341:Fibrinolysin; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
D007136:Immunoglobulins; D005341:Fibrinolysin
Administration intraveineuse d'immunoglobulines traitées par la plasmine. Etude durant deux ans chez seize patients ayant une carence humorale.