[Malignant lymphomas and sarcoidosis (author's transl)].
Five cases of sarcoidosis associated with malignant lymphoma are reported. In one patient, sarcoidosis was diagnosed several years after the onset of Hodgkin's disease. Of the remaining 4 patients, three developed nodular mixed lymphoma and one immunoblastic lymphoma (complicating angioimmunoblastic lymphadenopathy with dysproteinaemia) 3 months to 12 years after sarcoidosis were diagnosed. Such cases are extremely rare. They may be due to coincidence, but Danish epidemiological data suggest a relationship between the two diseases. Overstepping of humoral immunity in sarcoidosis may induce the emergence of a clone of formerly quiescent neoplastic B-cells.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006689:Hodgkin Disease / Q000209:etiology; D006801:Humans; D008171:Lung Diseases / Q000150:complications; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology; D008297:Male; D012507:Sarcoidosis / Q000150:complications* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
Association lymphomes malins sarcoïdose.