Determination of fragment D-dimer derivatives in serum reactive with antiserum against human fragment D-dimer.
A previous study demonstrated the preparation of an antiserum having enough specificity and sensitivity for a radioimmunoassay to determine fragment D-dimer derivatives. Using the antiserum the contents of fragment D-dimer derivatives in the sera of normal subjects and patients were determined. The content in normal subjects was 0.260 +/- 0.07 micrograms/ml (mean +/- SD) an that in patients with elevated levels of FDP ranged from 0.30 to 28 micrograms/ml. The values of fragment D-dimer derivatives and FDP in sera of some patients did not necessarily change in parallel, although there seems to be generally a positive correlation between them.
D000937:Antigen-Antibody Reactions; D002544:Cerebral Infarction / Q000276:immunology; D003920:Diabetes Mellitus / Q000276:immunology; D003928:Diabetic Nephropathies / Q000276:immunology; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis* / Q000276:immunology; D005341:Fibrinolysin / Q000502:physiology; D005342:Fibrinolysis; D006801:Humans; D007106:Immune Sera / Q000276:immunology*
D005338:Fibrin Fibrinogen Degradation Products; D007106:Immune Sera; D005341:Fibrinolysin