[Comparative studies of the effect of mithramycin and calcitonin on small intestine and pancreas function in the rat].
The effects of synthetic salmon calcitonin (Calcitonin R-Sandoz) at a dose of 10 IU/kg BW and Mithramycin (Mithramycin R-Pfizer) at a dose of 35 micrograms/kg BW on the absorption of calcium was evaluated in normocalcenic fasted rats by investigating both the pancreatic function and the intestinal absorption of xylose. During 2 h observation calcitonin induced a fall in serum calcium concentration of 6 % (p = n.s.). As compared with controls, the renal elimination of xylose is diminished in calcitonin treated animals by 49% (p less than 0,1), whilst in mithramycin treated animals no change is observed. Serum insulin level was not influenced by calcitonin, but it was stimulated about 70% (p less than 0,05) by mithramycin. Blood glucose concentration is decreased only by 14 mg % (calcitonin) and 18 mg % mithramycin) (p = n.s.). Both drugs do change neither urinary volume nor serum alpha-Amylase. It is concluded that the sites of action of mithramycin differ from those of calcitonin.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D007328:Insulin / Q000097:blood; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D008926:Plicamycin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014994:Xylose / Q000652:urine
D001786:Blood Glucose; D007328:Insulin; D002116:Calcitonin; D014994:Xylose; D008926:Plicamycin; D002118:Calcium
Vergleichende Untersuchungen zur Wirkung von Mithramycin und Calcitonin auf die Fünndarm- und Pankreasfunktion der Ratte.