[Effect of chronic administration of antidepressants on the binding of 3H-imipramine with mouse brain synaptic membranes].
Subchronic (14 days) administration of chlorimipramine and zimelidine, and a new morpholine derivative produces different effects on 3H-imipramine binding with synaptic membranes of the mouse brain. Chlorimipramine increases the concentration of the binding sites (Bmax), zimelidine raises both the Bmax and the dissociation constant, while the new morpholine derivative does not significantly change these characteristics. It has been demonstrated that the changes in the Bmax that occur during prolonged administration of chlorimipramine depend on the method for the obtaining of membrane brain preparations.
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D001921:Brain / Q000378:metabolism*; D002997:Clomipramine / Q000008:administration & dosage; D007099:Imipramine / Q000378:metabolism*; D008297:Male; D051379:Mice; D009022:Morphine Derivatives / Q000494:pharmacology; D013570:Synaptic Membranes / Q000378:metabolism*; D013997:Time Factors; D015031:Zimeldine / Q000008:administration & dosage
D000928:Antidepressive Agents; D009022:Morphine Derivatives; D015031:Zimeldine; D002997:Clomipramine; D007099:Imipramine
Vliianie khronicheskogo vvedeniia antidepressantov na sviazyvanie 3H-imipramina s sinapticheskimi membranami golovnogo mozga myshi.