Effect of African swine fever on lymphocyte mitogenesis.
The effect of African swine fever virus replication on T and B lymphocytes was studied by mitogen-driven assays. Live attenuated isolates caused a marked suppressive effect which was dose- and time-dependent. This effect appeared to be mediated through a monokine. Live virulent isolates enhanced lymphocyte mitogenesis in most cases, with increased [3H]-thymidine uptake by T cells and increased Ig secretion by B cells. Killed preparation had no effect. These results are discussed in the light of the allergic response and immunopathological lesions produced by African swine fever virus infections.
D000358:African Swine Fever Virus / Q000276:immunology*; D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007497:Iridoviridae / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013552:Swine; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D014779:Virus Replication
D007074:Immunoglobulin G; D011043:Pokeweed Mitogens; D003208:Concanavalin A; D013936:Thymidine