title: An experimental study of social isolation of elderly people: psychoendocrine and metabolic effects.
abstract: Psychoendocrine and metabolic effects of social isolation and understimulation in real life were examined in a controlled study of 60 elderly people representative of their age group. Together with the staff and the elderly, a social activation program was formed at a senior citizen apartment building. Half of the elderly were part of this activation program (experimental group). The other half constituted the control group. Blood sampling and psychosocial testing were performed immediately before and after 3 and 6 months of social activation. Social activation increased threefold in the experimental group. Height decreased in the control group compared to the experimental subjects. Plasma levels of testosterone, dehydroepiandrosterone, and estradiol increased significantly in the experimental group over the 6-month period compared to the control group. The most pronounced increase took place during the initial 3 months. Hemoglobin A1c decreased significantly in the experimental group over the 6-month period compared to the control group. In this preliminary study it is concluded that social isolation and understimulation may be associated with a wide range of psychophysiologic effects in elderly people.
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D003687:Dehydroepiandrosterone / Q000097:blood; D004573:Electrolytes / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012931:Social Environment; D012934:Social Isolation; D013739:Testosterone / Q000097:blood
chemical_list: D001786:Blood Glucose; D004573:Electrolytes; D006728:Hormones; D008055:Lipids; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D011388:Prolactin; D013006:Growth Hormone; D003404:Creatinine; D006854:Hydrocortisone