Turner's syndrome, 46X, del (X) (p 11), persistent complement activation and membranoproliferative glomerulonephritis.
An adolescent girl with short stature and learning disability was found to have an unusual variant of Turner's syndrome, 46X, del (X) (p 11) and an abnormal urinary sediment. Further studies demonstrated persistent depression of C3 and histologic evidence of membranoproliferative glomerulonephritis (MPGN). The occurrence of MPGN in this case may have been a manifestation of the known tendency for Turner patients to develop immunologic disease.
D001707:Biopsy, Needle; D002648:Child; D003176:Complement C3 / Q000172:deficiency*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications* / Q000473:pathology; D007668:Kidney / Q000473:pathology; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics; D014960:X Chromosome / Q000648:ultrastructure
D003176:Complement C3