Suppression of T cell responses through competition for T cell growth factor (interleukin 2).
Addition of activated T cells or of cells from a cytotoxic T cell clone to mixed leukocyte cultures abolished the generation of cytolytic activity in these cultures. The cytolytic T cell response is completely restored if T cell growth factor (interleukin 2) is added, indicating that the suppression is due to absorption or consumption of IL2 by the added cells.
D000818:Animals; D002999:Clone Cells / Q000276:immunology; D005260:Female; D007376:Interleukin-2 / Q000378:metabolism / Q000494:pharmacology*; D007959:Lymphocyte Culture Test, Mixed; D008222:Lymphokines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008811:Mice, Inbred DBA / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
D007376:Interleukin-2; D008222:Lymphokines