Effect of prostaglandins on Fc-IgG receptors of human circulating T and B lymphocytes.
A short preincubation of human T and B lymphocyte subpopulations with physiologic or pharmacologic concentrations of PGs E2 and F1 alpha, but not with E1 and F2 alpha, markedly depresses the cell ability to bind immune complexes, through FcR-IgG. This effect appears to be relatively temperature-independent. These observations indicate that PG treatment of human lymphocytes may be useful to distinguish the subclasses of FcR-IgG-bearing T and B cells, which are sensible to the modulating effect of PGs.
D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism*; D015237:Dinoprost; D015232:Dinoprostone; D006801:Humans; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011961:Receptors, Fc / Q000187:drug effects*; D017452:Receptors, IgG; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000378:metabolism*; D013696:Temperature; D013997:Time Factors
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011961:Receptors, Fc; D017452:Receptors, IgG; D015237:Dinoprost; D015232:Dinoprostone; C100006:prostaglandin F1