Increased mutational rates in Chinese hamster ovary cells serially selected for drug resistance.
Chinese hamster ovary cell populations exposed to the pressures of prolonged serial cultivation in cytotoxic drugs have increased mutational rates at independent genetic loci. Evidence suggests that the alterations generating these mutations may be independent of the lesions conferring drug resistance.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D004640:Emetine / Q000494:pharmacology; D005260:Female; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology; D005467:Floxuridine / Q000494:pharmacology*; D005796:Genes; D006822:Hybrid Cells / Q000187:drug effects; D009154:Mutation; D010042:Ouabain / Q000494:pharmacology; D010053:Ovary; D013866:Thioguanine / Q000494:pharmacology
D005467:Floxuridine; D010042:Ouabain; D013866:Thioguanine; D004640:Emetine