Selective failure of accessory cell function in Moloney murine leukemia virus-tolerant mice.
Accessory cell activity of spleen cells from M-MuLV neonatally injected (tolerant) mice was studied to evaluate their ability to take part in in vitro CTL generation against tumor-associated antigens induced by M-MSV. In contrast with accessory cell activity in normal spleen cells, spleen cells from M-MuLV-tolerant mice are unable to reconstitute the in vitro virus-specific CTL generation of M-MSV immune, Ia-depleted spleen cells. A selective defect seems to characterize M-MuLV-tolerant mice as their spleens constitute a good source of accessory cells for alloantigen CTL generation.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D007108:Immune Tolerance; D007942:Leukemia, Experimental / Q000276:immunology*; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008805:Mice, Inbred A; D008979:Moloney murine leukemia virus / Q000276:immunology; D013154:Spleen / Q000166:cytology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000956:Antigens, Viral