Human and murine cutaneous graft-versus-host diseases. Potential models for the study of immunologically mediated skin diseases.
Cutaneous graft-versus-host disease in humans can be regarded as a potential model for the study of lymphocytotoxic reactions directed against the epidermis, and immunologically mediated cutaneous sclerosis. Toxic epidermal necrolysis and lichen planus are closely reproduced in graft-versus-host disease; sclerosis of chronic graft-versus-host disease cannot be regarded as strictly similar to any type of scleroderma. Sclerosis is the most consistently reproducible feature of cutaneous graft-versus-host disease in mouse chimeras; it offers the opportunity to study a dermal sclerosing reaction which may be considered as T cell dependent. Murine graft-versus-host disease presently appears debatable for use as a model of T cell dependent injury of the epidermis since stable established epidermal lesions are difficult to reproduce.
D000818:Animals; D046508:Culture Techniques; D003602:Cytotoxicity, Immunologic; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D007108:Immune Tolerance; D008010:Lichen Planus / Q000276:immunology; D051379:Mice; D051381:Rats; D012598:Sclerosis; D013262:Stevens-Johnson Syndrome / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006649:Histocompatibility Antigens