title: Peripheral arterial disease diagnosed with high-count-rate radionuclide arteriography.
abstract: Thirty-seven patients with peripheral vascular disease involving the legs were studied with first-pass peripheral radionuclide arteriography (RNA) and contrast arteriography to determine whether RNA could be used to evaluate perfusion of the toes. Data were acquired for 100 seconds using a multicrystal gamma camera following bolus injection of 30-35 mCi (1,110-1,295 MBq) of Tc-99m-labeled albumin during reactive hyperemia. Peripheral time-activity curves were examined and the time required for activity to decline to 75% of peak activity ( T75 ) was recorded. When an abnormal RNA was defined as T75 greater than or equal to 50 seconds, sensitivity was 92%, positive predictive accuracy 100%, and negative predictive accuracy 75%. These data suggest that peripheral RNA of the toes is a reliable, noninvasive procedure for evaluation of peripheral arterial disease; it can be valuable as a screening test prior to contrast arteriography as well as for follow-up.
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D001162:Arteriosclerosis Obliterans / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D012709:Serum Albumin; D013667:Technetium; D013668:Technetium Tc 99m Aggregated Albumin; D013919:Thromboangiitis Obliterans / Q000000981:diagnostic imaging*; D014034:Toes / Q000098:blood supply
chemical_list: D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; D013667:Technetium