Modification of pancreatic carcinogenesis in the hamster model. XV. Preventive effect of nicotinamide.
The induction of pancreatic ductal-ductular adenomas (P = .05) and carcinomas (P less than .0001) by N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4; 2,2'-dioxo-N-nitrosodipropylamine] in Syrian golden hamsters was inhibited by nicotinamide (NA) (350 mg/kg body wt, ip) administered 10 minutes before and 3 hours after a single dose of BOP (10 mg/kg body wt, sc). The anticancer effect of NA and its relatively low toxicity in humans may provide a new lead in human cancer prevention.
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002277:Carcinoma / Q000139:chemically induced* / Q000473:pathology; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D009536:Niacinamide / Q000494:pharmacology*; D009602:Nitrosamines / Q000633:toxicity*; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D009602:Nitrosamines; D009536:Niacinamide; C013622:nitrosobis(2-oxopropyl)amine