title: Effect of Fusarium roseum corn culture containing zearalenone on early pregnancy in swine.
abstract: A corn culture of Fusarium roseum was added to a standard corn-soybean swine gestation ration. Low, middle, and high dosage mixed feeds contained 7, 38, and 64 mg of zearalenone/kg of feed (7, 38, and 64 ppm) and 0.5, 2.5, and 4.5 mg of deoxynivalenol/kg, respectively. Control feed was the standard ration without added F roseum corn culture. Mature gilts were bred by natural service and fed control or F roseum molded feed from 3 to 34 days after breeding. The main effect of the molded feed was an inhibition of fetal development, with decreased numbers of fetuses present in treated animals at slaughter (38 to 43 days after breeding). Normal litters were present in 7 of 8 control animals, in 2 of 4 gilts given the low-dosage feed, in 1 of 4 gilts given the medium dosage, and in 0 of 4 given the high-dosage feed. Corpora lutea were maintained in all treated animals, as evidenced by serum progesterone concentrations. Serum estradiol concentrations were decreased in gilts in the middle- and high-dosage groups. The genital system of the gilts fed low- and middle-dosage feeds had a gross and microscopic appearance similar to that of the pregnant controls and reflected prolonged progesterone stimulation. Morphologic changes in the genital system of the high-dosage group were intermediate between changes induced by progesterone and those induced by estrogen. Clinical signs of hyperestrogenism and partial feed refusal were noticed in only some of the high-dosage group animals.
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005670:Fusarium / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D008098:Litter Size / Q000187:drug effects; D009092:Mucous Membrane / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012118:Resorcinols / Q000494:pharmacology*; D013552:Swine / Q000502:physiology*; D013553:Swine Diseases / Q000209:etiology / Q000503:physiopathology; D014255:Trichothecenes / Q000494:pharmacology; D003313:Zea mays / Q000009:adverse effects; D015025:Zearalenone / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D012118:Resorcinols; D014255:Trichothecenes; D015025:Zearalenone; C007262:deoxynivalenol