[A simple and rapid method of studying the radiosensitizing ability of a drug in vivo by the study of hair dysplasia in the young mouse].
The study of radiation induced hair dysplasia in 8 day old mice allows investigations of the radiosensitizing power of a drug as early as the third day after irradiation without complicated equipment. The results being quantitative, they allow easy determination of the ER of a drug. In this study the method was applied to the action of metronidazol under anoxia.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006197:Hair / Q000528:radiation effects*; D008795:Metronidazole / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole
Méthode simple et rapide de la recherche du pouvoir radiosensibilisant d'une drogue in vivo par l'étude de la dysplasie pilaire chez le souriceau.