[Idiopathic chronic oral candidiasis in T-helper cell defect and heterozygote (MZ) alpha-1-antitrypsin deficiency].
The case of a 14-year-old girl is reported, suffering from a chronic oral candidiasis for the past 2 years. An immunologic T-cell defect was discovered: anergy in skin tests with recall antigens, negative lymphocyte stimulation tests with antigens and marked T-helper-cell depression in lymphocyte subpopulations. Thymopoietin-pentapeptide normalized the T-helper-cell number without clinical improvement. Complete remission was achieved after oral ketoconazole therapy.
D000293:Adolescent; D002180:Candidiasis, Oral / Q000235:genetics / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D006579:Heterozygote; D006801:Humans; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D000515:alpha 1-Antitrypsin
Idiopathische chronische orale Candidiasis bei T-Helferzelldefekt und heterozygotem (MZ) Alpha-1-Antitrypsinmangel.