[Comparison in vivo of the clastogenic properties of busulfan and cyclophosphamide].
Cyclophosphamide was given i.p. to male and female mice in order to study the dose--and the time--response relationship for structural chromosome aberrations induced in bone marrow cells. The results were compared to previous observations made with busulfan. After injection of cyclophosphamide the frequency of abnormal cells is maximal after 24 hours and decreases rapidly at longer intervals At comparable doses, the percentage of damaged cells is higher after treatment with busulfan and, due probably to the low solubility of the compound, reaches a maximum only after 48 hours. These results confirm that the most obvious potential drawback of this short term test is the transient nature of such anomalies.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002066:Busulfan / Q000633:toxicity*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009153:Mutagens
D009153:Mutagens; D003520:Cyclophosphamide; D002066:Busulfan
Comparaison, in vivo, des propriétés clastogéniques du busulfan et du cyclophosphamide.