In vitro activities of teichomycin, fusidic acid, flucloxacillin, fosfomycin, and vancomycin against methicillin-resistant Staphylococcus aureus.
Flucloxacillin, fosfomycin, fusidic acid, teichomycin, and vancomycin were tested against 50 clinical isolates of methicillin-resistant Staphylococcus aureus by a broth macrodilution technique. Teichomycin had a narrow range of activity, similar to that of vancomycin (0.5 to 2.0 micrograms/ml). Fusidic acid had the lowest range of inhibitory activity, with 50 and 90% MICs of 0.19 and 0.35 micrograms/ml, respectively. Flucloxacillin and fosfomycin showed less activity, with MICs up to 32 micrograms/ml.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005436:Floxacillin / Q000494:pharmacology; D005578:Fosfomycin / Q000494:pharmacology; D005672:Fusidic Acid / Q000494:pharmacology; D006020:Glycopeptides / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects*; D017334:Teicoplanin; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D005578:Fosfomycin; D005436:Floxacillin; D005672:Fusidic Acid; D017334:Teicoplanin; D014640:Vancomycin; D008712:Methicillin