Parathyroid-hormone-induced metabolic alkalosis in dogs.
We examined the effect of parathyroid hormone (PTH), administrated for 24-48 h, on acid-base homeostasis in dogs. Parathyroid extract (PTH), 15 IU/kg/day, given subcutaneously, caused metabolic alkalosis (control vs. experimental; mean +/- SEM): plasma HCO3, 21.3 +/- 0.3 vs. 24.2 +/- 0.5 mEq/l (p less than 0.001); plasma H+, 37.7 +/- 1.1 vs. 35.7 +/- 1.4 nEq/l (p less than 0.05), and net acid excretion, 48.6 +/- 2.0 vs. 65.1 +/- 4.0 mmol/day (p less than 0.01). PTH administered by continuous intravenous infusion had similar effects (control vs. experimental): plasma HCO3, 21.4 +/- 0.4 vs. 23.6 +/- 0.7 mEq/l (p less than 0.001) and net acid excretion, 54.0 +/- 3.5 vs. 68.3 +/- 5.7 mmol/day (p less than 0.05). PTH, 8 IU/kg/day, had qualitatively similar but quantitatively less profound consequences. Bicarbonaturia was not observed in any group. The effects of PTH were similar in adrenalectomized dogs maintained on hormone replacement. Indomethacin (150 mg/day) prevented the renal effects of PTH so that no increase in net acid secretion occurred. However, metabolic alkalosis still developed: control vs. experimental plasma HCO3, 21.8 +/- 0.5 vs. 23.9 +/- 0.5 mEq/l (p less than 0.001). Dichloromethanediphosphonate blunted both the renal and nonrenal effects of PTH, such that hypercalcemia, metabolic alkalosis and increased net acid excretion were quantitatively less and delayed in onset. In summary, PTH administration for 24-48 h causes metabolic alkalosis in dogs, the result of renal and nonrenal mechanisms.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000471:Alkalosis / Q000139:chemically induced*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001769:Blood; D002118:Calcium / Q000097:blood; D004002:Clodronic Acid / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000494:pharmacology; D008752:Methylene Chloride; D010281:Parathyroid Hormone / Q000494:pharmacology*; D014556:Urine
D001639:Bicarbonates; D010281:Parathyroid Hormone; D004002:Clodronic Acid; D008752:Methylene Chloride; D002118:Calcium; D007213:Indomethacin