[Role of the immunological factors in the pathogenesis of atherosclerosis].
It is shown that lipoproteins possessing autoantigenic properties may appear in blood serum of patients with atherosclerosis complicated by coronary disease. Developing sensitization to these lipoproteins, accompanied by the formation of an autoimmune complex may be the principal factor in the formation of arterial atherosclerotic lesions. Sensitization to vascular wall antigens is viewed as a factor contributing to rapid progress of atherosclerosis.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000276:immunology; D001011:Aorta / Q000276:immunology; D001018:Aortic Diseases / Q000209:etiology*; D001161:Arteriosclerosis / Q000209:etiology*; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology*; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology*; D008074:Lipoproteins / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D001324:Autoantigens; D008074:Lipoproteins
Rol' immunologicheskikh faktorov v patogeneze ateroskleroza.