[Mezlocillin concentrations in human lung tissue].
The antibiotic concentrations were determined in 28 serum samples, 24 samples of lung parenchyma and 21 samples of the skeletal muscle from 28 patients who had undergone pneumonectomy. 5 g mezlocillin had been given i. v. as a bolus injection 30 to 150 minutes before sampling. The concentrations in the lung tissue were higher than the MICs for most bacteria for two hours. If a strain is less sensitive, a dose of more than 5 g is recommended. The concentrations in muscle tissue were also effective antibacterially.
D000328:Adult; D000368:Aged; D006801:Humans; D008168:Lung / Q000032:analysis*; D008175:Lung Neoplasms / Q000601:surgery; D008802:Mezlocillin; D008875:Middle Aged; D009132:Muscles / Q000032:analysis; D010406:Penicillins / Q000032:analysis* / Q000097:blood
D010406:Penicillins; D008802:Mezlocillin
Mezlocillin-Konzentrationen im menschlichen Lungengewebe.