[Neonatal bacterial infections. Kinetic study of C-reactive protein and orosomucoid].
Changes in serum concentrations versus time of C reactive protein and orosomucoid were investigated in 134 neonates with either materno-foetal infection (group A, n = 111) or nosocomial infection (group B, n = 23). Both proteins were significantly elevated in group A neonates, with mean +/- S.E.M. values of 0.029 +/- 0,003 g/l for C reactive protein (n = 111) and 0.56 +/- 0.003 g/l for orosomucoid (n = 37). In cases with superinfection serum levels of both proteins rose before clinical symptoms developed. Changes in orosomucoid concentrations occurred a few hours after changes in C reactive protein concentrations. Monitoring C reactive protein and orosomucoid levels, in an excellent means of assessing the effectiveness of treatment and of deciding on its withdrawal when both proteins return to normal values.
D001424:Bacterial Infections / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D003428:Cross Infection / Q000097:blood; D004927:Escherichia coli Infections / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D009961:Orosomucoid / Q000032:analysis*; D018805:Sepsis / Q000097:blood; D013290:Streptococcal Infections / Q000097:blood; D013292:Streptococcus agalactiae; D013997:Time Factors
D009961:Orosomucoid; D002097:C-Reactive Protein
Infections bactériennes néo-natales. Etude cinétique de la C réactive protéine et de l'orosomucoïde.