Maternal and fetal pharmacokinetics of moxalactam given intrapartum.
Two grams of moxalactam was given intravenously to 28 women at high risk for infection following cesarean delivery. After a mean time of 48 minutes from infusion, maternal sera, cord sera, and uterine tissue obtained at delivery had concentrations of moxalactam of 62 micrograms/ml, 22.2 micrograms/ml, and 9.6 micrograms/gm, respectively. The maternal serum half-time was calculated to b e 2.1 hours. R and S epimeric distribution was determined in these sera and tissues, and the mean R/S ratios were 0.95, 0.93, and 1.22 for the three groups, respectively. The significance of these observations is discussed. A new method in which a high-pressure liquid chromatographic assay is used is described, and results are compared to those obtained with the microbiological assay. The high-pressure liquid chromatographic method was found to be quick, accurate, an reproducible.
D001431:Bacteriological Techniques; D002511:Cephalosporins / Q000378:metabolism*; D002513:Cephamycins / Q000097:blood / Q000378:metabolism*; D002585:Cesarean Section / Q000009:adverse effects; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D017053:Infection Control; D007700:Kinetics; D009070:Moxalactam; D011247:Pregnancy; D012306:Risk; D014599:Uterus / Q000032:analysis*
D002511:Cephalosporins; D002513:Cephamycins; D009070:Moxalactam