[Regulation of immunoglobulin production: role of the cellular receptors for the Fc portion of these molecules].
The aim of this paper was to review the action of the receptors for the Fc portion of Ig on the polyclonal activation of human B lymphocytes. The IgG Fc fragments were shown to be digested by monocytes into peptides which triggered B-cell differentiation and the release of a T-cell replacing factor termed (Fc)TRF. In the presence of PWM and monocytes, unbound aggregated IgG suppressed B-cell differentiation into Ig-synthesizing cells. This suppression was not isotype-specific. After having bound aggregated IgG, T cells were able to display an isotype-restricted suppression of B-cell differentiation induced by PWM. Finally, soluble Fc gamma R released from T or B lymphocytes or neutrophils were found to inhibit both the synthesis of IgG and the maturation of B cells into IgM or Ig A-secreting cells.
D000921:Antibody-Producing Cells / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000378:metabolism; D007136:Immunoglobulins / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D009000:Monocytes / Q000276:immunology*; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D013601:T-Lymphocytes / Q000276:immunology
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007136:Immunoglobulins; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic
Régulation de la production d'immunoglobulines: rôle des récepteurs cellulaires de la partie Fc de ces molécules.