[Lymphocyte subpopulations in hemophilic patients].
Monoclonal antibody analysis of peripheral blood T-cell subsets was performed in 23 multitransfused haemophiliacs, 5 children and 10 adults. Although none of the patients exhibited symptoms of acquired immune deficiency, 5 of them showed an abnormally low proportion of T-cells with reversal of the OKT4 (helper/inducer) to OKT8 (cytotoxic/suppressor) ratio. No evidence of cytomegalovirus infection was found. A search for antibodies to human leukaemia virus antigen P24 gave negative results. The relationship between this abnormality and transfusions is discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D006467:Hemophilia A / Q000097:blood* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008214:Lymphocytes / Q000145:classification* / Q000473:pathology; D008875:Middle Aged
D000914:Antibodies, Viral
Etude des sous-populations lymphocytaires chez l'hémophile.