Anticoccidial activity of crown polyethers.
Anticoccidial activity in vitro against Eimeria tenella is reported for crown polyethers with ring sizes from 14 to 30 atoms. The most potent compounds, 4 and 9, were found active at 0.33 ppm, but none were active in vivo. Test results are discussed in terms of lipophilic shielding of complexed cations.
D000818:Animals; D001692:Biological Transport; D002478:Cells, Cultured; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy*; D004539:Eimeria / Q000187:drug effects; D004988:Ethers, Cyclic / Q000627:therapeutic use*; D007668:Kidney / Q000469:parasitology; D008564:Membrane Potentials; D011108:Polymers / Q000627:therapeutic use*
D004988:Ethers, Cyclic; D011108:Polymers