The effect of skin grafts on the ratio of collagen types in human post-burn wound tissues.
Pepsin digests of human post-burn wound tissues grafted with autologous fresh skin showed a significantly lower ratio, 0.37 +/- 0.04 (mean +/- S.D.), of type III to type I collagen determined by interrupted gel electrophoresis than the ratio, 0.55 +/- 0.13, measured in ungrafted wound tissues (p less than 0.001). In wounds grafted with frozen skin there was no significant difference from ungrafted wounds, but a significantly higher ratio, 0.46 +/- 0.08, than that in wounds grafted with fresh skin (p less than 0.001). These results were consistent with the histological features of the wound tissues.
D000328:Adult; D002056:Burns / Q000378:metabolism* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000032:analysis*; D005260:Female; D006097:Granulation Tissue / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010434:Pepsin A; D016038:Skin Transplantation
D003094:Collagen; D010434:Pepsin A