[Decrease in the number of SE-rosettes by means of sera containing immune complexes].
The number of peripheral blood lymphocytes (PBL) rosetting with sheep erythrocytes (SE-rosettes) was significantly decreased by preincubation with both sera containing immune complexes (IC) and prepared antigen-antibody complexes. However, this effect of decrease in rosetting ability of PBL could be completely reversed by a second incubation of the cells for 30 minutes at 37 degrees C in IC-free medium. The immune complexes and antigen-antibody complexes respectively could bind reversibly to T cells via Fc-receptors and subsequently interfere with the T cell receptors for SE by steric hindrance.
D000818:Animals; D000936:Antigen-Antibody Complex; D001769:Blood; D002417:Cattle; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D011961:Receptors, Fc / Q000032:analysis; D012397:Rosette Formation / Q000379:methods*; D012756:Sheep
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011961:Receptors, Fc
Senkung der SE-Rosettenzahl durch Immunkomplexe enthaltende Seren.