title: Down's syndrome and acute megakaryoblastic leukaemia. Case report and review of the literature.
abstract: A case is reported of a child with Down's syndrome who developed acute megakaryoblastic leukaemia, and in whom the evolution of the disease was accompanied by increasing cytogenetic abnormalities. A review of the literature suggests that the presence of an abnormal chromosome 21 may predispose to the development of this type of leukaemia.
mesh_terms: D000208:Acute Disease; D001792:Blood Platelets / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000235:genetics / Q000473:pathology; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000235:genetics / Q000473:pathology