title: Biocement--a new material. Results of its experimental use for osseous repair of skull cap defects with lesions of the dura mater and liquorrhea, reconstruction of the anterior wall of the frontal sinuses and fixation of alloimplants.
abstract: A newly developed material, which we call biocement, consisting of bisphenol-a-glycidyl methacrylate ("epoxide methacrylate') as organic matrix and Bioceramic Battelle, Bioglass Hench and/or pentacalcium hydroxide triphosphate ("tri-calcium phosphate') powder as filling particles is presented. In an extension of previous experiments, various types of this biocement, containing different admixtures of particulate matter, were employed to test their usefulness in head surgery, in particular maxillo-facial reconstruction, on dogs and a rhesus monkey. Encouraging results were obtained with regard to (a) fixing a titanium alloimplant under some degree of mechanical stress; (b) covering a defect in the skull cap, including the closure of an artificially induced meningeal fistula with liquorrhea; and (c) reconstruction of defects in the anterior wall of frontal sinuses. Special emphasis is placed on direct contact between biocement and bone, interdigitations between these two, reactions of meningeal tissue, and regeneration of ciliated epithelium underneath fixed reimplants over the frontal sinus.
mesh_terms: D000179:Acrylates / Q000627:therapeutic use*; D000818:Animals; D001585:Benzoyl Peroxide / Q000627:therapeutic use*; D017438:Bisphenol A-Glycidyl Methacrylate; D001843:Bone Cements / Q000627:therapeutic use*; D003188:Composite Resins / Q000627:therapeutic use*; D004285:Dogs; D004388:Dura Mater / Q000601:surgery; D005260:Female; D005624:Frontal Bone / Q000601:surgery; D005626:Frontal Sinus / Q000601:surgery; D008253:Macaca mulatta; D008297:Male; D008338:Mandibular Injuries / Q000601:surgery; D008689:Methacrylates / Q000627:therapeutic use*; D010027:Osteotomy / Q000379:methods; D010545:Peroxides / Q000627:therapeutic use*; D012886:Skull / Q000473:pathology / Q000601:surgery*; D012887:Skull Fractures / Q000601:surgery; D014052:Toluidines / Q000627:therapeutic use*
chemical_list: D000179:Acrylates; D001843:Bone Cements; D003188:Composite Resins; D008689:Methacrylates; D010545:Peroxides; D014052:Toluidines; D017438:Bisphenol A-Glycidyl Methacrylate; C015835:dimethyl-4-toluidine; D001585:Benzoyl Peroxide