[Effector functions of the polynuclear eosinophil].
The effector function of eosinophils is studied in experimental models, emphasizing the prominent role played by antibodies among which IgE, and also the activation of the cytotoxic activity by mast cell-derived ECF. A tetrapeptides. The demonstration of the cytolytic effect of basic proteins present in eosinophil granules allows to clarify this mechanism on a molecular basis. Eosinophil effector function is then envisaged in various clinical situations. In pulmonary eosinophilias, a relation appears between the detection of proteins released by eosinophils and the tissue damage. Eosinophils seem also to be implied in the inflammatory process characteristic of endomyocardial disease or in Crohn's disease. Whereas they were first considered as beneficial cells for the host, the eosinophil granulocytes may therefore express according to the targets, a dual either beneficial or nocious function.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001798:Blood Proteins / Q000502:physiology; D009202:Cardiomyopathies / Q000276:immunology; D002631:Chemotactic Factors, Eosinophil / Q000502:physiology; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000737:chemistry / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology / Q000469:parasitology; D009203:Myocardial Infarction / Q000276:immunology; D011657:Pulmonary Eosinophilia / Q000276:immunology; D051381:Rats; D017455:Receptors, IgE; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000502:physiology; D012260:Ribonucleases; D012552:Schistosomiasis / Q000276:immunology
D001798:Blood Proteins; D002631:Chemotactic Factors, Eosinophil; D047091:Eosinophil Granule Proteins; D007074:Immunoglobulin G; D017455:Receptors, IgE; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D007073:Immunoglobulin E; D012260:Ribonucleases
Fonctions effectrices du polynucléaire éosinophile.