Lymphocyte subpopulations in Hodgkin's disease and non-Hodgkin's lymphoma and the effects of radiotherapy.
Examination of peripheral blood lymphocyte subsets in untreated patients with Hodgkin's disease and non-Hodgkin's lymphoma revealed depressed ratios of helper/suppressor T-cells, assessed with monoclonal antibodies OKT4 and 8. Non-Hodgkin's lymphoma and Hodgkin's disease patients studied from 1 to 204 months following treatment by radiotherapy also demonstrated depressed ratios, although the patients were clinically free of disease. The failure of the helper T-cells to recover following apparently successful treatment suggests that either the initial disease or the radiotherapy produces a virtually irreversible effect on T-cell subpopulations. Treated Hodgkin's disease patients also exhibited a long term increase in B-cell numbers but this effect could be correlated with splenectomy performed during staging laparotomy.
D001402:B-Lymphocytes / Q000276:immunology / Q000528:radiation effects; D006689:Hodgkin Disease / Q000276:immunology* / Q000532:radiotherapy; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000145:classification / Q000276:immunology* / Q000528:radiation effects; D008223:Lymphoma / Q000276:immunology* / Q000532:radiotherapy; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000528:radiation effects; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000528:radiation effects