[Localization of pheochromocytomas by scintigraphy with meta-iodobenzyl guanidine. Comparison with computed x-ray tomography].
Meta-iodobenzylguanidine was synthesized, radiolabelled with I 131 or I 123 and injected to 28 controls and 7 patients totalling 13 foci of pheochromocytoma. The tumour was located in one adrenal gland in 3 cases, in both adrenal glands in 1 case, and between the aorta and the vena cava in 1 case; 2 were malignant with metastases. Scintigraphy was negative in all controls, whereas all pheochromocytomas were clearly demonstrated 24 h after injection, except one regarded as non functional due to necrosis. By comparison, CT readily showed the tumour in 7 cases, showed it only thanks to scintigraphic guidance in 4 cases and failed in 2 cases. It is concluded that scintigraphy with meta-iodobenzylguanidine provides a safe and reliable means of locating a wide range of pheochromocytomas.
D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging*; D000313:Adrenal Medulla / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D010673:Pheochromocytoma / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine
Localisation des phéochromocytomes par la scintigraphie à la méta-iodobenzylguanidine. Comparaison avec la tomodensitométrie.