[Properties of membrane ionic currents in pituitary clone cells].
Membrane ionic currents of the GH3 pituitary cell line have been studied using voltage clamp techniques. The inward current is completely blocked by cobalt (Co2+) ions and appeared to be carried by calcium ions. Three outward currents can be differentiated on the ground of kinetics and pharmacological studies: a transient current blocked by 4-aminopyridine (4 AP) and two delayed outward current which are voltage dependent. One is blocked by tetraethylammonium (TEA); the second is blocked by Co2+ and represents a calcium-activated potassium conductance.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D002999:Clone Cells / Q000187:drug effects / Q000502:physiology; D003035:Cobalt / Q000494:pharmacology; D004594:Electrophysiology; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D051381:Rats; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D000631:Aminopyridines; D013757:Tetraethylammonium Compounds; D003035:Cobalt; D019789:Tetraethylammonium; D015761:4-Aminopyridine
Propriétés des courants ioniques membranaires d'un clone de cellules hypophysaires.