title: [Thrombocythemia with Philadelphia chromosome. Secondary appearance of chronic myeloid leukemia].
abstract: The finding of a Philadelphia chromosome in a case of apparently primary thrombocythaemia should change the diagnosis for that of chronic myeloid leukaemia. This theoretical view is supported by the case reported here, where a Philadelphia-chromosome was detected in the bone marrow cells of a patient with severe thrombocythaemia; a typical myeloid leukaemia developed 21 months after the onset of the disease; survival was of short duration.
mesh_terms: D000328:Adult; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D011289:Preleukemia / Q000235:genetics*; D013922:Thrombocytosis / Q000235:genetics*; D013997:Time Factors
vernacular_title: Thrombocythémie avec chromosome Philadelphie. Apparition secondaire d'une leucémie myéloïde chronique.