[Cell surface changes after high-dosage progesterone treatment in endometrial carcinoma].
Scanning electron microscopic examination revealed conspicuous superficial changes in endometrial carcinoma, primarily in highly differentiated cases, after treatment with high doses of a progesterone compound (Depo-Provera). The most important changes included decrease of superficial structure, distruction of microvilli, loosening of intercellular connection and disintegration of the glandular substance. In consequence a barren, poorly structured, "devastated" pattern was seen, which points to the regressive processes on intracellular plane occurring on the effect of progestagens. Results confirmed the hypothesis of the close relationship between intracellular and cell surface processes.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000648:ultrastructure*; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives; D017258:Medroxyprogesterone Acetate; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000187:drug effects / Q000648:ultrastructure; D008875:Middle Aged; D011300:Preoperative Care; D011374:Progesterone / Q000008:administration & dosage*; D013499:Surface Properties; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000648:ultrastructure*
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D011374:Progesterone; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone
Zelloberflächenveränderungen nach hochdosierter Progesteronbehandlung bei Endometriumkarzinom.