The immunomodulating effect of TP5 and indomethacin in burn-induced hypoimmunity.
Hypoimmunity after major trauma and thermal injury appears to predispose to septicemia. An increase of immune suppressive T cells and the inhibitory monocytes product PGE2 has been demonstrated postburn and are suggested as contributing to postburn hypoimmunity. TP5, the biologically active part of thymopoientin, has an immunomodulating effect on T cells. Indomethacin, an irreversible blocker of the prostaglandin synthesis has been suggested to reduce the inhibitory monocytes-mediated immunosuppression. In this study strains 2 and 13 guinea pigs received 20-30% TBSA scald burn and were subsequently injected with either TP5 or indomethacin or a combination of both on the 3 following days postburn. The ability of splenocytes to produce a secondary immune response to SRBC was measured in the in vitro AFC assay. The animals who had received TP5 and indomethacin showed significant improvement in their ability to mount an immune response in the AFC assay.
D000818:Animals; D002056:Burns / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D006728:Hormones / Q000627:therapeutic use*; D007108:Immune Tolerance / Q000187:drug effects*; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D009000:Monocytes / Q000276:immunology; D010446:Peptide Fragments / Q000627:therapeutic use*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D016305:Thymopentin; D013946:Thymopoietins / Q000627:therapeutic use*; D013951:Thymus Hormones / Q000627:therapeutic use*
D006728:Hormones; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; D016305:Thymopentin; D007213:Indomethacin