Diabetes mellitus in mice induced by multiple subdiabetogenic doses of streptozotocin: age and sex dependence.
In order to investigate whether age and sex have an influence on induction and development of diabetes, male and female C57Bl/KsJ mice of different ages were treated with subdiabetogenic injections of streptozotocin for five consecutive days. After a long period of observation all treated animals became diabetic. Male mice showed higher plasma glucose values than female animals suggesting a sex dependence. In the first phase of diabetes development the hyperglycemic response was dependent on the age of the mice. Animals treated during puberty, both male and female developed a more rapid onset of hyperglycemia and a more severe diabetes than the other age groups. The increased plasma glucose levels were accompanied in mice treated after and during puberty by an inflammatory lesion of the endocrine pancreas.
D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000209:etiology*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012737:Sex Factors; D013311:Streptozocin / Q000008:administration & dosage*
D001786:Blood Glucose; D013311:Streptozocin