Combination chemotherapy pneumonitis: a case report of possible synergistic toxicity.
A woman with pancreatic cancer developed acute interstitial infiltrates while receiving modest doses of two potential pulmonary toxins, mitomycin-C and chlorozotocin. Chemotherapy pneumonitis, confirmed by lung biopsy, responded dramatically to prednisone with negligible sequelae. Comparison with the doses in other reported cases suggested additive or synergistic toxicity between these two alkylating agents.
D000230:Adenocarcinoma / Q000188:drug therapy; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016685:Mitomycin; D008937:Mitomycins / Q000009:adverse effects*; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D011014:Pneumonia / Q000139:chemically induced*; D013311:Streptozocin / Q000009:adverse effects / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D008937:Mitomycins; C007028:chlorozotocin; D016685:Mitomycin; D013311:Streptozocin