Reduced number of skeletal muscle fiber nuclei in Down syndrome: speculation on a "shut off" role of chromosome 21 in control of DNA and nuclear replication rates, possibly via determination of cell surface area per nucleus.
D002451:Cell Compartmentation; D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure*; D002874:Chromosome Mapping; D002904:Chromosomes, Human, 21-22 and Y; D004261:DNA Replication; D004314:Down Syndrome / Q000235:genetics*; D005796:Genes; D006801:Humans; D009132:Muscles / Q000648:ultrastructure*