Changes of the fibrinolytic system of animals induced by injection of tissue plasminogen activator.
The changes in the fibrinolytic system of rats induced by repeated injections of tissue plasminogen activator (TPA) have been studied. The euglobulin fraction fibrinolytic activity increases 10 min after the first injection of TPA. Repeated injections of TPA for one or more days do not stimulate the fibrinolytic activity or TPA accumulation in the blood. Apparently in the absence of fibrin clots in the blood flow of healthy animals TPA is incapable of activating plasminogen conversion into plasmin. TPA, in its turn, is rapidly bound to the antiactivator and is excreted from the organism.
D000818:Animals; D001780:Blood Coagulation Tests; D002118:Calcium / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism; D005342:Fibrinolysis; D007275:Injections, Intravenous; D008297:Male; D010960:Plasminogen Activators / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012712:Serum Globulins / Q000032:analysis; D013997:Time Factors
D012712:Serum Globulins; D010960:Plasminogen Activators; D005341:Fibrinolysin; D002118:Calcium