Studies on experimental immune complex nephritis (3). Therapeutic effect of prostaglandin E1 alpha-cyclodextrin host molecule (PGE1 . CD) on serum sickness nephritis in rats.
The effect of prostaglandin E1 alpha-cyclodextrin host molecule (PGE1 . CD) was estimated by using a model of immune complex glomerulonephritis induced in rats by i.v. injection of 1 mg of rabbit serum albumin every other day. PGE1 . CD was given subcutaneously for 10 days after nephritis was definitely induced and resulted in a rapid restoration of various biochemical parameters, especially in plasma. The continuous s.c. administration of PGE1 . CD (300 micrograms/rat/day) with a mini osmotic pump provoked a therapeutic effect similar to that obtained with twice daily s.c. administration of PGE1 . CD (300 micrograms/rat X 2/day). Both PGE1 . CD groups revealed less glomerular damage and fewer locations of immune complexes in glomeruli as demonstrated by light and immunofluorescence microscopy. The beneficial effect of PGE1 . CD may be associated with reduced immune complex deposits in glomeruli. The present studies suggest that PGE1 . CD may enhance the clearance of immune complex deposits from the glomeruli rather than inhibiting the formation of immune complex in the circulation.
D000118:Acetylglucosaminidase / Q000652:urine; D000469:Alkaline Phosphatase / Q000652:urine; D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003505:Cyclodextrins / Q000627:therapeutic use*; D003912:Dextrins / Q000627:therapeutic use*; D005455:Fluorescent Antibody Technique; D006160:Guanosine Triphosphate / Q000652:urine; D006949:Hyperlipidemias / Q000188:drug therapy; D007105:Immune Complex Diseases / Q000188:drug therapy* / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008297:Male; D009393:Nephritis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011458:Prostaglandins E / Q000627:therapeutic use*; D011507:Proteinuria / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D013213:Starch / Q000627:therapeutic use*; D013997:Time Factors; D014511:Uremia / Q000188:drug therapy; D047391:alpha-Cyclodextrins
D003505:Cyclodextrins; D003912:Dextrins; D011458:Prostaglandins E; D047391:alpha-Cyclodextrins; C043214:prostaglandin E1-alpha-cyclodextrin; D006160:Guanosine Triphosphate; D013213:Starch; D000469:Alkaline Phosphatase; D000118:Acetylglucosaminidase; D000527:Alprostadil