Intracerebroventricular injection of cerebrospinal fluid (CSF) from a patient with congenital indifference to pain induces analgesia in rats.
CSF from a patient with congenital indifference to pain was found to produce analgesia in the rat following intracerebroventricular injections. The analgesic effect was attenuated by pretreatment with naloxone suggesting the involvement of hyperactive endogenous opiate mechanisms in this patient.
D000328:Adult; D000698:Analgesia; D000818:Animals; D002555:Cerebrospinal Fluid / Q000502:physiology*; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D000699:Pain Insensitivity, Congenital / Q000134:cerebrospinal fluid*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology
D011957:Receptors, Opioid; D009270:Naloxone