[Effect of nicotinic acid and nicotinamide on the activity of NADPH- and NADH-dependent redox chains in rat liver endoplasmic reticulum].
Nicotinic acid and nicotinamide injected to rats subcutaneously in a dose of 100 mg/kg produce after 4 hours an inhibition in liver microsomes of N-demethylation of amidopyrine, NADPH.H-ferricytochromo-c-, NAD.H-ferricytochromo-b5-oxidoreductases and NAD.H-oxidase. After 12 hours they stimulate p-hydroxylation of aniline, NADP.H-ferricytochromo-c-oxidoreductase, NADP.H-oxidase, NAD.H-ferricyanide- and NAD.H-ferricytochromo-b5-oxidoreductases. The content of cytochrome P450 and activity of NADP.H-nitrotetrasolium-reductase were decreased by that time.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D015786:Cytochromes b5; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009525:Niacin; D009536:Niacinamide / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D051381:Rats
D000814:Aniline Compounds; D003580:Cytochromes; D009539:Nicotinic Acids; D000632:Aminopyrine; D009536:Niacinamide; D009525:Niacin; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D009247:NADH, NADPH Oxidoreductases; C023650:aniline
Vliianie nikotinovoĭ kisloty i nikotinamida na aktivnost' fermentov NADF.H-i NAD.H-zavisimykh redoks-tsepeĭ éndoplazmaticheskogo retikumuma pecheni krys.