Differential sensitivity to photohemolysis of erythrocytes enriched with some liposome-carried substances.
The sensitivity of human erythrocytes to photohemolysis sensitized by addition of protoporphyrin IX can be selectively affected by their enrichment with substances carried by cationic liposomes. In particular the enrichment which superoxide dismutase is accompanied by a copper-related greater sensitivity toward photohemolysis, as observed in the Down's syndrome (mongolism). Instead it is possible to protect the erythrocytes against the phototoxic effect of protoporphyrin by enrichment with small amounts of beta-carotene.
D000818:Animals; D002338:Carotenoids / Q000494:pharmacology*; D002417:Cattle; D004314:Down Syndrome / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects* / Q000528:radiation effects; D006801:Humans; D007700:Kinetics; D008027:Light; D008081:Liposomes; D011524:Protoporphyrins / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology; D019207:beta Carotene
D008081:Liposomes; D011524:Protoporphyrins; D019207:beta Carotene; D002338:Carotenoids; C028025:protoporphyrin IX; D013482:Superoxide Dismutase