title: Anaesthesia for a patient with Down's syndrome and Eisenmenger's complex.
abstract: A patient with Down's syndrome and Eisenmenger's complex presented for orthopaedic surgery on the elbow under general anaesthesia. During pre-oxygenation, in order to prevent a subsequent fall in systemic vascular resistance, metaraminol 1 mg was administered intravenously. The patient immediately developed bradycardia, mild hypertension and became deeply cyanosed. His condition rapidly improved after atropine 0.6 mg was given intravenously. Following induction of anaesthesia with thiopentone and tracheal intubation facilitated by suxamethonium, anaesthesia was maintained by mechanical ventilation of the lungs with nitrous oxide and oxygen (40%) with intravenous increments of fentanyl for analgesia and pancuronium for muscle relaxation; residual neuromuscular blockade was reversed with neostigmine. The patient made an eventful recovery. Although general anaesthesia is tolerated by patients with Eisenmenger's complex, powerful vasoactive drugs should not be administered unless specifically indicated.
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General; D001919:Bradycardia / Q000139:chemically induced; D004314:Down Syndrome / Q000150:complications*; D004541:Eisenmenger Complex / Q000150:complications*; D006801:Humans; D006810:Humeral Fractures / Q000601:surgery; D008297:Male; D008680:Metaraminol / Q000009:adverse effects; D000092464:Elbow Injuries
chemical_list: D008680:Metaraminol