Ipratropium bromide and fenoterol by aerosolized solution.
Ipratropium bromide (0.5 mg) and fenoterol (2 mg) produced equivalent peak bronchodilatation between 1 and 2 h after administration to eight patients with chronic partially reversible airways obstruction. The duration of action compared with saline was 6 h for ipratropium and 4 h for fenoterol. Both drugs in combination produced greater bronchodilatation than either drug alone. The increase in FVC was disproportionately greater than FEV1 with both drugs and saline, suggesting relief of obstruction of small airways.
D000336:Aerosols; D000368:Aged; D001286:Atropine Derivatives / Q000008:administration & dosage*; D004983:Ethanolamines / Q000008:administration & dosage*; D005280:Fenoterol / Q000008:administration & dosage* / Q000627:therapeutic use; D005541:Forced Expiratory Volume; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage* / Q000627:therapeutic use; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012996:Solutions; D014797:Vital Capacity
D000336:Aerosols; D001286:Atropine Derivatives; D004983:Ethanolamines; D012996:Solutions; D005280:Fenoterol; D009241:Ipratropium