Canine model for microvascular reconstruction of the larynx.
The experimental use of jejunal free grafts with microvascular anastomosis in the head and neck region has been reported in pharyngeal and esophageal reconstruction. Lack of a suitable animal model has limited basic research for cutaneous or myocutaneous microvascular techniques. This investigation upon appropriate graft sites in the canine was instituted. Following a vertical hemilaryngectomy, reconstruction of the laryngeal defect was accomplished by transferring 2.5 to 3.5 centimeters square of a free myocutaneous graft from the caudal ventral abdominal region. The skin surface of the graft was placed inward to reline the laryngeal lumen. The epigastric artery and vein attached to the free graft were anastomosed to the superior thyroid or laryngeal artery or vein. Four of the six animals survived the procedure. All animals which survived the surgery showed excellent preservation of the airway lumen, pseudocord formation, and viability of the graft.
D000009:Abdominal Muscles / Q000098:blood supply / Q000637:transplantation; D000818:Animals; D004285:Dogs; D005260:Female; D007830:Larynx / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008954:Models, Biological; D012867:Skin / Q000098:blood supply; D016038:Skin Transplantation; D013524:Surgical Flaps