title: A lipid peroxidative mechanism for posterior subcapsular cataract formation in the rabbit: a possible model for cataract formation in tapetoretinal diseases.
abstract: Posterior subcapsular cataracts developed in rabbits following injection of docosahexenoic acid. Autoxidation of docosahexenoic acid in rabbit vitreous was demonstrated by the formation of malondialdehyde and vitreous fluorescence. The onset of posterior subcapsular cataract formation was temporally correlated with declining levels of vitreous malondialdehyde.
mesh_terms: D000818:Animals; D002386:Cataract / Q000378:metabolism*; D004281:Docosahexaenoic Acids; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D008314:Malonates / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*; D010084:Oxidation-Reduction; D010786:Photoreceptor Cells / Q000378:metabolism*; D011817:Rabbits; D012162:Retinal Degeneration / Q000378:metabolism
chemical_list: D005231:Fatty Acids, Unsaturated; D008314:Malonates; D004281:Docosahexaenoic Acids; D008315:Malondialdehyde