title: Percutaneous absorption of iodochlorhydroxyquin in humans.
abstract: Iodochlorhydroxyquin (I) is used in the treatment of diaper rash and other skin disorders, and is presumed to undergo little or no percutaneous absorption. The absorption of (I) from a 3% cream was studied in 5 normal male subjects after a single application of the cream for 12 h. Plasma levels of the drug were followed for 24 h after initial application while urinary excretion was measured for 54 h. (I) was extracted from plasma and urine and assayed by high-performance liquid chromatography. The drug in the range of 0.37-0.56 micrograms/ml was detected in plasma 2 h after application and persisted throughout the treatment period. The mean excretion rate after 12 h of application was 58.4 micrograms/h and the excretion rate was 8.8 micrograms/h at 42 h posttreatment. The elimination rate constant was calculated to be 0.15 h-1. Approximately 40% of the drug was absorbed over the 12-h application period. From the above results it is apparent that significant percutaneous absorption of (I) occurs.
mesh_terms: D000042:Absorption; D000287:Administration, Topical; D000328:Adult; D007464:Clioquinol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D006912:Hydroxyquinolines / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D012867:Skin / Q000378:metabolism*
chemical_list: D006912:Hydroxyquinolines; D007464:Clioquinol