[Vigilance behavior in interaction of the serotonin-selective antidepressant zimelidine and parenterally administered ethanol].
A randomized, placebo-controlled double-blind crossover study was carried out in 8 healthy male subjects to evaluate the interaction of (Z)-3-(4-bromphenyl)-N,N-dimethyl-3-(3-pyridyl)-allylamine-dihydrochloride-monohydrate (zimelidine, Normud) -- a new antidepressive drug -- and alcohol. New methodological approaches to the problem consisted in a parenteral application of ethanol and the introduction of the computer-assisted Oculodynamic Test -- a new multi-dimensional psychophysiological research instrument -- monitoring saccadic eye movements, choice-reaction parameters and cardiorespiratory parameters. Classical disimprovement of these parameters after ethanol infusion (equivalent to 1 mg % BEC) could be seen up to 5 h after administration. Alcohol effects were not potentiated by the selective serotonin-reuptake inhibitor zimelidine -- in contrary even a significant vigilance-stabilizing effect and improvement against placebo/ethanol values could be demonstrated for most of the vigilance-related parameters.
D000328:Adult; D001288:Attention / Q000187:drug effects*; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004311:Double-Blind Method; D004347:Drug Interactions; D004585:Electrooculography; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D012438:Saccades / Q000187:drug effects; D015031:Zimeldine
D011725:Pyridines; D015031:Zimeldine; D000431:Ethanol; D001977:Brompheniramine
Vigilanzverhalten bei Interaktion des Serotonin-selektiven Antidepressivums Zimelidin mit parenteral verabreichtem Alkohol.