Duodeno-pancreatic secretions enhance bactericidal activity of antimicrobial drugs.
We have studied the action of various antimicrobial agents in microbiological media and in human duodeno-pancreatic secretions. In the latter medium, clioquinol exhibited a rapid bactericidal effect on both growing and stationary bacteria at concentrations near its MIC. However, it was merely bacteriostatic in microbiological media, even at high concentrations. Phanquinone, chlorquinaldol, and, to a lesser extent, also chloramphenicol and trimethoprim likewise displayed enhanced bactericidal activity in duodeno-pancreatic secretions, but various other antibacterial agents did not. These findings suggest that duodeno-pancreatic secretions contain a factor augmenting the antibacterial activity of a number of drugs.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D007464:Clioquinol / Q000494:pharmacology; D003470:Culture Media; D003967:Diarrhea / Q000382:microbiology; D004386:Duodenum / Q000378:metabolism / Q000502:physiology*; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010179:Pancreas / Q000378:metabolism / Q000502:physiology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D007464:Clioquinol