Chemotherapy trials in malignant pheochromocytoma: report of two patients and review of the literature.
Two patients with metastatic pheochromocytoma received chemotherapy with 5-fluorouracil, cyclophosphamide, and streptozotocin. A biochemical response occurred in one instance. A review of the literature and the results in the reported patients indicate cyclophosphamide and/or streptozotocin may have activity in this neoplasm.
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D000328:Adult; D002395:Catecholamines / Q000378:metabolism; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010673:Pheochromocytoma / Q000188:drug therapy* / Q000378:metabolism; D011446:Prospective Studies; D013311:Streptozocin / Q000008:administration & dosage*
D002395:Catecholamines; D013311:Streptozocin; D003520:Cyclophosphamide; D005472:Fluorouracil