title: Enzymic editing mechanisms and the origin of biological information transfer.
abstract: Current knowledge of enzymic editing mechanisms in DNA replication, transcription and translation can be used to predict error rates in the absence of editing. Primitive enzymes which possessed synthetic activity but not yet editing mechanisms would have had extremely high error rates resulting in heterogeneous proteins. Based on present knowledge of molecular biology and biochemistry, it is concluded that the evolution of contemporary information transfer systems from primitive systems lacking such editing mechanisms remains an unsolved problem in theoretical biology.
mesh_terms: D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics; D010584:Bacteriophage phi X 174 / Q000235:genetics; D005075:Biological Evolution; D004261:DNA Replication; D004798:Enzymes / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D005815:Genetic Code; D008957:Models, Genetic; D009154:Mutation; D014176:Protein Biosynthesis
chemical_list: D004798:Enzymes