[Lichen planus. Study of the T-lymphocyte population and Langerhans cells using monoclonal antibodies].
The purpose of the present study was to examine the phenotype of the immunocompetent cells in cutaneous infiltrates and peripheral blood in Lichen Planus. 14 patients have been studied using Monoclonal Antibodies directed against T cell populations. We have used in this study the indirect immunofluorescence technique. Helper cells (OKT4+) and Suppressor/cytotoxic cells (OKT8+) have been observed in all cutaneous infiltrates, and numerous Langerhans cells identified by OKT6 in epidermis and dermis. In peripheral blood, the balance between the two major T cell subsets (OKT4+ and OKT8+) was increased by a reduction of the percentage of Suppressor/cytotoxic cells. This balance is statistically significant (P 0,02). Our results confirm the existence of a lymphocytotoxic process in Lichen Planus.
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology*; D008010:Lichen Planus / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal
Liquen plano. Estudio de la población linfocitaria T y células de Langerhans a través de los anticuerpos monoclonales.