Early hypertension and cardiac work.
Myocardial function and ventricular work in early essential hypertension were assessed by comparing systemic hemodynamics and echocardiographic data in 33 normotensive subjects and 38 hypertensive patients, all without left ventricular hypertrophy. External work (tension-time index and cardiac work) and internal work (fiber shortening velocity) were significantly increased in the patients with mild hypertension. Because factors other than blood pressure contribute to cardiac work, antihypertensive therapy must favorably affect both blood pressure and cardiac work.
D000328:Adult; D001794:Blood Pressure; D006332:Cardiomegaly / Q000503:physiopathology; D004452:Echocardiography; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D005082:Physical Exertion