Autoregulation of autoantibody synthesis in mercuric chloride nephritis in the Brown Norway rat. I. A role for T suppressor cells.
Mercuric chloride injections in the Brown Norway rat induce the transient formation of anti-glomerular basement membrane (GBM) autoantibodies. Transfer of spleen cells from convalescent animals, after circulating anti-GBM autoantibodies are no longer detectable, inhibits reinduction of the disease by HgCl2 in naive recipients. This inhibition is significantly less when the T suppressor cell population is depleted by the monoclonal antibody, MRC OX8 , before transfer. Our studies suggest a role for T suppressor cells in autoregulation in this animal model of autoimmune nephritis and may form a basis for the design of specific therapy for anti-GBM disease in man.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D005260:Female; D006706:Homeostasis; D007116:Immunization, Passive; D007700:Kinetics; D008212:Lymphocyte Depletion; D008627:Mercuric Chloride; D008628:Mercury; D009393:Nephritis / Q000139:chemically induced / Q000276:immunology*; D051381:Rats; D011914:Rats, Inbred BN / Q000276:immunology*; D011919:Rats, Inbred Strains / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D001323:Autoantibodies; D008627:Mercuric Chloride; D008628:Mercury