Increased helper-suppressor T-cell ratio in psoriasis.
Numerous investigations have suggested an immunologic pathogenesis of psoriasis and diminished suppressor T-cell activity of psoriatic blood. Consequently, a study was undertaken to explain whether diminished suppressor cell activity was a result of quantitative alterations of the T-lymphocyte subpopulation. Twenty patients with psoriasis and 20 normal control subjects were randomly selected. Our findings demonstrated a significant decrease in the percentage of suppressor cells (T gamma), a significant elevation of helper cells (T mu), and a highly significant increase in the helper-suppressor T-cell ratio (T mu/T gamma) of psoriatic blood compared with that of normal control subjects. Our study gives further support to the possible role of immunologic factors in the pathogenesis of psoriasis.
D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D011565:Psoriasis / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology; D012397:Rosette Formation; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology*; D050378:T-Lymphocytes, Regulatory / Q000473:pathology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011971:Receptors, Immunologic