The effects of radiosensitizers on intermediary metabolism in vivo.
In the liver, MISO has little effect on glycolytic intermediates but both the lactate and G3P contents are significantly decreased shortly after administration, whereas the level of ketone-bodies is raised. The changes in hepatic metabolite levels following treatment with SR-2508 are less marked. However, in an adenocarcinoma, both the lactate and ketone-body concentrations are enhanced with MISO. The redox equilibria states are shifted to the oxidized metabolites in the liver but instead to the reduced metabolites in tumor. These effects may have relevance for the radiotherapy in tumors.
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000378:metabolism; D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D004099:Dihydroxyacetone Phosphate / Q000378:metabolism; D017341:Etanidazole; D005994:Glycerophosphates / Q000378:metabolism; D006885:Hydroxybutyrates / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008920:Misonidazole / Q000494:pharmacology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*; D009593:Nitroimidazoles / Q000494:pharmacology; D011773:Pyruvates / Q000378:metabolism; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D000090:Acetoacetates; D005994:Glycerophosphates; D006885:Hydroxybutyrates; D007773:Lactates; D009593:Nitroimidazoles; D011773:Pyruvates; D011838:Radiation-Sensitizing Agents; D017341:Etanidazole; C016635:acetoacetic acid; D004099:Dihydroxyacetone Phosphate; D008920:Misonidazole; C029620:alpha-glycerophosphoric acid; D020155:3-Hydroxybutyric Acid