The retinoids in acne.
Vitamin A is essential for growth and development, reproduction and vision in humans. Chemical modification of vitamin A has yielded compounds showing therapeutic promise in skin and neoplastic diseases. The medicinal use of retinoids (vitamin A and its derivatives) is limited by the toxicity associated with this group of compounds. One retinoid, 13-cis-retinoic acid, has proved to be quite effective in the treatment of severe recalcitrant cystic acne under conditions in which toxicity is manageable.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D006801:Humans; D006986:Hypervitaminosis A; D015474:Isotretinoin; D008297:Male; D012176:Retinoids / Q000009:adverse effects / Q000627:therapeutic use*; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000503:physiopathology
D012176:Retinoids; D014212:Tretinoin; D015474:Isotretinoin