title: Absence of siderophore activity in Legionella species grown in iron-deficient media.
abstract: Growth of Legionella species in a defined medium deficient in iron did not result in the production of phenolic or hydroxamate siderophores which could be detected by chemical or biological assay methods. Growth of a variety of other gram-negative organisms under the same conditions resulted in the production of both hydroxamate and phenolate siderophores. The iron-deficient medium limited growth of the Legionella species more severely than it did the growth of the other gram-negative organisms. We have concluded that Legionella species do not make the commonly recognized siderophores, probably because they are restricted in their growth to those environments in which inorganic iron is readily available or is supplied in a form bound to an unknown carrier.
mesh_terms: D001681:Biological Assay; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000096:biosynthesis*; D007875:Legionella / Q000378:metabolism*; D017262:Siderophores
chemical_list: D007502:Iron Chelating Agents; D017262:Siderophores; D007501:Iron