title: Ninth International Histocompatibility pre-workshop testing of Dw6 HTCs. Two subtypes of Dw6.
abstract: In the scope of the cellular part of the 9th International Histocompatibility Workshop, the offered homozygous typing cells (HTCs) of several specificities have been screened in a pre-Workshop. In Leiden and Seattle all HTCs typing for "HLA-Dw6" have been tested. This implied that in both laboratories mixed lymphocyte culture (MLC) matrices were performed between the Dw6 HTCs and that all HTCs were tested as stimulator cells against a panel of heterozygous responder cells. The results clearly demonstrated that "HLA-Dw6" as defined by the different participating laboratories can be split into two major groups, Dw6.a and Dw6.b. This observation confirms and extends previous reports. None of the 9th Workshop B-cell sera could discriminate between the two presently described subgroups of HLA-Dw6.
mesh_terms: D006684:HLA-DR Antigens; D006579:Heterozygote; D000949:Histocompatibility Antigens Class II / Q000145:classification / Q000276:immunology*; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed
chemical_list: D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II