Inhibition of mammary tumorigenesis in nulliparous C3H mice by chronic feeding of the synthetic retinoid, N-(4-hydroxyphenyl)-retinamide.
Feeding of N-(hydroxyphenyl)retinamide (4-HPR) (1.0 mM/kg diet) for 39 weeks to 2 month old nulliparous C3H/Crgl mice significantly (p less than 0.01) reduced the incidence of mammary tumors; 98 control mice developed a total of 235 mammary tumors, 100 4-HPR treated mice developed 171 mammary tumors. Feeding the same dietary level of 4-HPR to 4-6 month old multiparous C3H mice for 14 weeks did not significantly influence the development of mammary tumors; 78 control mice developed a total of 115 mammary tumors; 78 4-HPR treated mice developed 130 mammary tumors. Body weight gains were comparable among 4-HPR treated mice and control mice. Significant suppression of mouse mammary gland tumorigenesis in vivo by dietary retinoids (nulliparous C3H mice) has heretofore not been reported.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D017313:Fenretinide; D008325:Mammary Neoplasms, Experimental / Q000503:physiopathology / Q000517:prevention & control*; D051379:Mice; D008809:Mice, Inbred C3H; D011247:Pregnancy; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology
D017313:Fenretinide; D014212:Tretinoin