Escape of tumours from immunological destruction.
This paper reviews the mechanisms of tumour escape from immune destruction that have been delineated in the past 2 decades. Current evidence indicates that the principal escape mechanisms are (i) weak or absent immunogenicity (ii) immunosuppression by tumour antigens or antigen-antibody complexes (iii) induction of suppressor cells and (iv) production of immunosuppressive factors. A classification of tumour escape mechanisms is presented.
D000368:Aged; D000818:Animals; D000906:Antibodies / Q000502:physiology; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D006801:Humans; D007109:Immunity; D007121:Immunocompetence; D007165:Immunosuppression Therapy; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000503:physiopathology; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm