Comparison of cytotoxicity of mercury-selenium and mercury compounds on cultured cells.
In vitro effects of mercury-selenium (Hg-Se) compounds, as compared with their original mercury compounds, against growth and viability of HeLa cells were studied. A water-soluble, ethanol-insoluble black complex (GX) formed from HgCl2, Na2SeO3 and GSH was less toxic than HgCl2, but the cytotoxicity of bis(methylmercuric) selenide (BMS) seemed to be similar to that of methylmercury. This may be due to the instability of BMS; i.e., there is a possibility that BMS decomposed to methylmercury and selenium under our culture conditions.
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008627:Mercuric Chloride; D008628:Mercury / Q000633:toxicity*; D008767:Methylmercury Compounds / Q000633:toxicity*
D008767:Methylmercury Compounds; C027499:bis(methylmercuric)selenide; D008627:Mercuric Chloride; D008628:Mercury; C004925:methylmercuric chloride