title: [Evaluation of the effectiveness of an antirabies serum purified and concentrated by the Prosdis-4 method].
abstract: The data on the use of rabies antitoxin obtained by the method ensuring the isolation of active immunoglobulin fractions are presented. The trial was carried out in the Kazakh SSR and the Uzbek SSR. The preparation was injected to subjects bitten by animals, in doses of 5 to 40 ml, depending on the localization of bites, the character of lesions and the age of victims. Antitoxin " Prosdis -4" was found to possess low reactogenicaty . During the term of observation (1 year) no cases of rabies were registered among the immunized victims.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D001733:Bites and Stings / Q000628:therapy; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D007623:Kazakhstan; D008297:Male; D008875:Middle Aged; D011818:Rabies / Q000517:prevention & control; D011820:Rabies virus / Q000276:immunology*; D012882:Skin Tests; D013997:Time Factors; D014610:Uzbekistan
chemical_list: D000914:Antibodies, Viral; D007106:Immune Sera
vernacular_title: Otsenka éffektivnosti antirabicheskoĭ syvorotki, ochishchennoĭ i kontsentrirovannoĭ po metodu "Prosdis-4".