Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.
An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported. Clinical and biochemical abnormalities disappeared soon after discontinuation of PTU. That the drug was directly responsible for the observed complications is suggested by the clinical course and by in vitro lymphocyte transformation studies. The latter revealed sensitization to PTU during the acute phase of the disease, which was greatly reduced 5 weeks after discontinuation of the drug and was completely absent after 5 months.
D000380:Agranulocytosis / Q000139:chemically induced*; D056486:Chemical and Drug Induced Liver Injury; D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008875:Middle Aged; D011441:Propylthiouracil / Q000009:adverse effects*
D011441:Propylthiouracil