Suppressive effect of antibodies to immune response gene products on the development of low-dose streptozotocin-induced diabetes.
Low-dose streptozotocin-induced diabetes in mice serves as a model of type I diabetes. Suppression of the development of diabetes (hyperglycemia) in C3H/He mice was achieved with in vivo administration of antibody reactive to Ir-gene products before streptozotocin treatment. A persistent effect was reached with two monoclonal antibodies directed against I-Ak gene products and, surprisingly, by an allo-antiserum to I-J determinants. These results suggest a role for I-A and I-J positive T-lymphocytes and/or macrophages in B-islet cell autoimmunity.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology / Q000517:prevention & control*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000517:prevention & control*; D005802:Genes, MHC Class II; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013311:Streptozocin / Q000008:administration & dosage
D000911:Antibodies, Monoclonal; D013311:Streptozocin