[Effect of cyproterone acetate on the 3 alpha-hydroxysteroid-dehydrogenase activity of cutaneous fibroblasts in culture].
In men, parallel variations in urinary 3 alpha 5 alpha androstane 17 beta diol with the amount of sex skin fibroblast DHT receptors rise the question of a relationship of 3 ketosteroid reductase activity and specific DHT binding. To test this hypothesis, we measured 3 alpha 5 alpha androstane 17 beta diol biosynthesis in cultured sex skin fibroblasts, in the presence of high amounts of cyproterone acetate which competes with DHT for its receptor: when 95% of DHT is displaced by cyproterone acetate, the 3 keto steroid reductase activity remains unchanged. These results suggest that the relationship of 3-keto-steroid reductase activity and androgen receptors is unlikely.
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D046508:Culture Techniques; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000652:urine; D017373:Cyproterone Acetate; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011944:Receptors, Androgen / Q000187:drug effects; D012867:Skin / Q000187:drug effects / Q000201:enzymology*
D003272:Contraceptive Agents, Male; D011944:Receptors, Androgen; D017373:Cyproterone Acetate; D003534:Cyproterone; D006913:Hydroxysteroid Dehydrogenases
Action de l'acétate de cyprotérone sur l'activité 3 alpha-hydroxystéroïde déshydrogénase du fibroblaste cutané en culture.