[Short- or long-term antibiotic prophylaxis in obstetric and gynecologic laparotomy?].
This clinical trial was conducted to test the effectiveness of short-term prophylaxis (1 hour before, 8 and 16 hours after surgery) and long-term prophylaxis (8 hour a part 5 days long post-operatively) in preventing morbidity related to obstetrics and gynecological abdominal surgery. Short-term prophylaxis was always performed by cefuroxime meanwhile gynecological long-term prophylaxis was performed by ampicillin plus oxacillin and by cefuroxime in case of obstetrical surgery. The results showed that long-term prophylaxis is unnecessary and short-term prophylaxis is preferable because of decreased toxicity, a smaller hospital dispensary cost and a real prophylactic action because tha antibiotic is in the tissue before exposure to the infective agents.
D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002444:Cefuroxime / Q000008:administration & dosage; D002585:Cesarean Section; D004630:Emergencies; D005260:Female; D006801:Humans; D007044:Hysterectomy; D010068:Oxacillin / Q000008:administration & dosage; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D011247:Pregnancy; D011292:Premedication; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D002444:Cefuroxime; D010068:Oxacillin
Profilassi antibiotica a breve o a lungo termine nella laparochirurgia ostetrica e ginecologica?