[Inductive effects of enzymes of salicylic acid derivatives].
In the series of salicylic acids derivatives investigated 3,5-DIS has a large inductive effect of enzymes with respect to the metabolism of xenobiotics: rise in the rate of Cyt. P 450; increase of ethoxycoumarin deethylase, bilirubin glucuronosyl transferase and benzphetamine-N-demethylase activities. This effect is comparable with that of phenobarbital.
D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction; D014453:Glucuronosyltransferase; D006602:Hexosyltransferases / Q000096:biosynthesis*; D007463:Iodobenzoates / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis*; D010105:Oxygenases / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates
D007463:Iodobenzoates; D012459:Salicylates; C019787:bilirubin glucuronoside glucuronosyltransferase; C020891:3,5-diiodosalicylic acid; C008152:4-iodosalicylic acid; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; C019781:benzphetamine N-demethylase; D010089:Oxidoreductases, N-Demethylating; D006602:Hexosyltransferases; D014453:Glucuronosyltransferase
Effets inducteurs d'enzymes des dérivés salicylés.