title: SG-75 induction of increased coronary outflow and PGE1 from ischemic areas in dogs with experimental myocardial infarction.
abstract: We measured the coronary blood flow and concentrations of prostaglandin E1(PGE1), PGF2 alpha, and lactate from the ischemic myocardium of dogs treated with either SG-75 or indomethacin. There was a significant increase of coronary blood outflow from the ischemic myocardium after ligation in dogs given SG-75 and in control dogs compared with indomethacin-treated dogs. The release of lactate from the ischemic myocardium decreased significantly in dogs with SG-75 compared with the indomethacin and control group. The concentration of PGE1 rose significantly after ligation in dogs with SG-75 compared indomethacin-treated and those in control dogs. A significant release of PGE1 from the ischemic area of the myocardium treated with SG-75 was clearly demonstrated at 60 min after ligation of the LAD coronary artery. Also, a significant release of PGF2 alpha from the ischemic area of the myocardium was demonstrated at 15 min after ligation. There was a significant correlation between the increase of coronary outflow and PGE1 release from the ischemic myocardium ( 4= 0.70, p less than 0.01). However, no significant correlation was demonstrated between the increase of coronary outflow and PGF2 alpha. These results show a close relation ship between increased coronary outflow induced by SG-75 and increased release of PGE1. Thus, a beneficial effect of SG-75 on the ischemic myocardium was demonstrated.
mesh_terms: D000527:Alprostadil; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D015232:Dinoprostone; D004285:Dogs; D007213:Indomethacin / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism; D009203:Myocardial Infarction / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism*; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D020108:Nicorandil; D011458:Prostaglandins E / Q000378:metabolism*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D007773:Lactates; D011458:Prostaglandins E; D014665:Vasodilator Agents; D009536:Niacinamide; D020108:Nicorandil; D000527:Alprostadil; D015232:Dinoprostone; D007213:Indomethacin