Phenotypic analysis of T cell subsets in the blood of chronically aborting women.
A relative decrease in helper and a parallel increase in suppressor-cytotoxic T lymphocytes was found in the blood of six habitually aborting women, as compared with the T-cell subset distribution in ten normal multiparae and eight multigravid post-partum women. It is suggested that an imbalance between the immunoregulatory T-cell subpopulations may contribute to the rejection of the semiallogenic fetus.
D000026:Abortion, Habitual / Q000097:blood / Q000276:immunology*; D000328:Adult; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology