T gamma and theophylline-sensitive T lymphocytes in allergic contact dermatitis.
Two lymphocyte subpopulations, T cells bearing a receptor for the Fc fragment of IgG (T gamma) and theophylline-sensitive T cells, were investigated in 49 patients with allergic contact dermatitis (ACD) in the acute phase and compared with a control group. Patients with ACD had markedly reduced relative T gamma and theophylline-sensitive T lymphocyte levels, compared with normals (P less than 0.0005). The patients also showed reduced absolute T gamma and theophylline-sensitive T cells with respect to the controls (P less than 0.01). To determine whether decreased levels of T gamma and theophylline-sensitive T cells were related to the activity of ACD, the same T-cell subsets were determined in 10 of 49 patients after the clearing of the contact dermatitis. Both T-cell subpopulations were found within the normal range.
D000293:Adolescent; D000328:Adult; D003877:Dermatitis, Contact / Q000097:blood / Q000276:immunology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011961:Receptors, Fc; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013806:Theophylline / Q000494:pharmacology*
D011961:Receptors, Fc; D013806:Theophylline