Reduced GABA transaminase activity in the Huntington's disease putamen.
GABA transaminase activity is reduced in autopsied putamen samples from patients dying with Huntington's disease. Its activity is also reduced in the striatum of rats previously lesioned with kainic acid. In both cases, the reduction in GABA transaminase activity is comparable with the reduction in glutamate decarboxylase activity, supporting the suspected localization of this enzyme to GABA neurones within the basal ganglia.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000201:enzymology*; D007608:Kainic Acid / Q000494:pharmacology; D011699:Putamen / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D012016:Reference Values
D002795:Choline O-Acetyltransferase; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase; D007608:Kainic Acid