title: Fc gamma bearing T cells in non-Hodgkin lymphoma.
abstract: T-cell subpopulations have been implicated in the regulation of normal human B-cell reactivity. As the non-Hodgkin lymphomas (NHL) represent predominantly clonal B-cell malignancies, we examined the relationship of total T-cell [Sheep Red Blood Cell (SRBC) binding] and Fc gamma bearing T-cell populations in these disorders. Peripheral blood from seven low-grade (Rai stage 0), six high-grade (Rai stage 3 or 4) CLL patients, lymph node specimens from five patients with WDLL, seven patients with PDLL-D, three patients with MC-D, and eight patients with DHL were studied. All values were compared to normal controls. The percentage of total T cells in each disease category was decreased compared to controls. In addition, there was a reproducible correlation between the percentage of Fc gamma bearing T cells and the histopathologic diagnosis. The percentage of Fc gamma bearing T cells was highest in low-grade CLL and decreased incremently from high-grade CLL and WDLL, to MC-D, and PDLL-D. In DHL, we found no Fc gamma bearing T cells. Finally, the percentage of Fc gamma bearing T cells in each disease category was decreased compared to controls. These findings suggest a correlation between Fc gamma bearing T cells and the clinical aggressiveness of disease in NHL. In addition, they may raise important questions about therapy. Finally, they may offer a useful clinical test as an adjunct to histopathology although this will need to be confirmed in larger series.
mesh_terms: D006801:Humans; D007126:Immunoglobulin Allotypes / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000097:blood / Q000473:pathology; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000097:blood* / Q000473:pathology; D011961:Receptors, Fc / Q000032:analysis*; D017452:Receptors, IgG; D013601:T-Lymphocytes / Q000145:classification* / Q000378:metabolism / Q000473:pathology
chemical_list: D007126:Immunoglobulin Allotypes; D011961:Receptors, Fc; D017452:Receptors, IgG