title: [Benefits of intensive preoperative irradiation in combined therapy of breast cancer].
abstract: The therapeutic, social and economic aspects of the efficacy of intense preoperative irradiation in combined therapy of breast cancer were analysed. It has been established that preoperative irradiation in the form of the fractionation of a single focal dose of 6 Gy every other day, the summary dose of 24 Gy within 8-10 days followed by surgery 1-3 days after irradiation does not either complicate its performance or the course of the postoperative period, and by the short- and long-term results it is no worse than the routine dose fractionation. Large dose fractionation saves the time of preoperative irradiation (10 days instead of 5-6 weeks), reduces the time of inpatients' stay (56-70 days instead of 90-100 days), enables most of the patients after treatment to resume work 1.2-2 mos. earlier than after the routine dose fractionation. Preoperative irradiation in the form of large dose fractionation reduces the time of treatment, does not change its efficacy and provides for a greater economic effect.
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D003365:Costs and Cost Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000191:economics; D012426:Russia
vernacular_title: Preimushchestva intensivnogo preoperatsionnogo oblucheniia pri kombinirovannom lechenii raka molochnoĭ zhelezy.