Heart and kidney involvement during antihypertensive treatment. Results from the primary preventive trial in Göteborg, Sweden.
The prevalence of signs of heart (Minnesota-coded ECG, chest X-ray) and kidney involvement (proteinuria, abnormal serum creatinine) was studied before and after 5 years' antihypertensive treatment in 686 middle-aged, hypertensive men derived from a screening examination of a random population sample. The prevalences of heart enlargement (X-ray) and abnormally high serum creatinine increased. A pronounced regression of S-T and T wave changes in the ECG was achieved. In a subgroup of 375 patients without digitalis therapy and not having had myocardial infarction, ECG signs of left ventricular hypertrophy decreased.
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000453:epidemiology / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000453:epidemiology / Q000517:prevention & control*; D003404:Creatinine / Q000097:blood; D004562:Electrocardiography; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000453:epidemiology / Q000517:prevention & control; D013548:Sweden
D000959:Antihypertensive Agents; D003404:Creatinine