Effect of pH on the formation of Tc(NaBH4)-MDP radiopharmaceutical analogues.
Anion exchange high performance liquid chromatography has been employed to separate components of 99mTc(NaBH4)-MDP formulations prepared as a function of pH, the presence or absence of 99Tc carrier, and the presence or absence of air. The formulation pH is an effective variable for controlling the generation and interconversion of 99mTc-MDP components, and for allowing the preparation of large quantities of specific 99mTc-MDP complexes for biological evaluation.
D000388:Air; D001842:Bone and Bones / Q000000981:diagnostic imaging; D001894:Borohydrides; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004164:Diphosphonates; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011877:Radionuclide Imaging; D013667:Technetium; D013669:Technetium Tc 99m Medronate
D001894:Borohydrides; D004164:Diphosphonates; D013667:Technetium; C025364:sodium borohydride; D013669:Technetium Tc 99m Medronate