T-lymphocytes with both helper- and suppressor markers on the same cell in chronic lymphocytic leukaemia.
A 62-year-old Norwegian male was found to have a leucocytosis (20 X 10(9)/l blood). About 80% of the leucocytes were T-lymphocytes with markedly convoluted, often cerebriforme nuclei. There were generalized pea-sized lymph nodes. The liver was enlarged and was found to be infiltrated with the same type of lymphocytes as were found in the blood. A bone marrow biopsy showed massive infiltration with the same kind of cells. The patient had a non-specific rash, but no generalized exfoliative dermatitis. A double set of markers was found on the T-lymphocytes, with a membrane phenotype T4+ and T8+ on practically all cells.
D000911:Antibodies, Monoclonal / Q000276:immunology; D002467:Cell Nucleus / Q000473:pathology / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000648:ultrastructure; D006408:Hematoma, Subdural / Q000276:immunology / Q000473:pathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000648:ultrastructure; D008099:Liver / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000648:ultrastructure; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal