Metabolism of ethylmalonate to mesaconate in the rat. Evidence for trans-dehydrogenation of methylsuccinate.
Rats excrete increased ethylmalonate and methylsuccinate when given ethylmalonate in the diet; when given methylsuccinate they excrete methylsuccinate and mesaconate. Tenfold more labelled mesaconate was produced from threo-methyl[2,3-2H2] succinate precursor than from the erythro isomer. Our findings suggest trans-dehydrogenation of methylsuccinate and are the first direct evidence linking the metabolism of ethylmalonate, methylsuccinate and mesaconate.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D008298:Maleates / Q000378:metabolism*; D008314:Malonates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates / Q000378:metabolism*
D008298:Maleates; D008314:Malonates; D013386:Succinates; C038080:ethylmalonic acid; C039138:methylsuccinic acid