title: [Relations between Ia antigens and the products of Ir genes. A theory of the evolution of the immune response].
abstract: To explain the relations between Ia and Ir, we propose the following hypothesis. It would exist an antigen specific factor released by T lymphocytes. This factor would be constituted by two parts: a variable fragment forming the antigenic receptor of T cells and coded by Ir genes, a constant fragment transmitting an helper or suppressor signal and carrying Ia antigens. Ia antigens would allow a mutual recognition between macrophages, T lymphocytes and B lymphocytes and a recognition by these cells of some mediators released during immune response. Ir genes products would allow the antigen recognition, if they correspond to the antigenic receptor of T lymphocytes.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D000950:Antigens, Ly / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D000950:Antigens, Ly; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II
vernacular_title: Relations entre antigènes Ia et produits des gènes Ir. Une théorie sur le déroulement de la réponse immunitaire.