title: Leukaemia in children with Down's syndrome.
abstract: Between 1971 and 1981 756 children were diagnosed to have leukaemia in Hungary. Of these, 17 had Down's syndrome. Analyzing the clinical course of their leukaemia revealed a low remission rate and very poor survival in these patients. Down's syndrome seems to present a special high-risk feature, for early death or relapse into leukaemia, which is only partially explained by the accompanying abnormalities.
mesh_terms: D001772:Blood Cell Count; D002648:Child; D004314:Down Syndrome / Q000150:complications* / Q000401:mortality; D005260:Female; D006801:Humans; D006814:Hungary; D007938:Leukemia / Q000150:complications*; D007948:Leukemia, Monocytic, Acute / Q000150:complications; D008297:Male; D008423:Maternal Age; D011336:Probability; D012042:Registries; D012737:Sex Factors