[Effect of nicotinamide on focal and generalized epileptic activity in the cerebral cortex].
Intraperitoneal injection of nicotinamide to rats inhibits epileptic activity induced by penicillin application in the animals' brain cortex. It has been found in experimental primary-generalized epileptic activity induced by bemegride that preliminary injection of nicotinamide increased the latency of the emergence of the first epileptic seizures. Addition of nicotinamide to synaptosomal suspension inhibited accumulation in it of the products of lipid peroxidation. Relationship between antioxidant properties of nicotinamide and its antiepileptic activity is discussed.
D000818:Animals; D001534:Bemegride / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000188:drug therapy*; D009536:Niacinamide / Q000627:therapeutic use*; D010406:Penicillins / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors
D010406:Penicillins; D009536:Niacinamide; D001534:Bemegride
Vliianie nikotinamida na ochagovuiu i generalizovannuiu ĕpilepticheskuiu aktivnost' v kore golovnogo mozga.