Ehrlich ascites cells activate the alternative pathway of the human complement system.
Incubation of Ehrlich ascites cells with normal or C1q or C2 deficient human sera results in killing of the cells. Killing occurred also in the absence of free Ca++, which supported by the fact that factor B and C3 were cleaved, leads to the conclusion that the alternative pathway of the complement system is activated on the surface of the Ehrlich ascites cells.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D003602:Cytotoxicity, Immunologic; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D011951:Receptors, Complement; D017463:Receptors, Complement 3b
D011951:Receptors, Complement; D017463:Receptors, Complement 3b