title: [Immunomorphological analysis of the level of differentiation of hepatocellular tumors in rats].
abstract: Combinations of three molecular markers (alpha-fetoprotein, ligandin and A-protein) were investigated in individual cells of the rat hepatocellular tumours by means of indirect immunofluorescence. It was found that each subtype of trabecular carcinoma classified on the basis of cytomorphological appearance as well, moderately, and poorly differentiated hepatomas, exhibited its characteristic combination(s) of the molecular markers studied. Each marker pattern observed in the tumours had its counterpart in the marker combination specific to one of the stages of normal liver tissue differentiation. Thus immunomorphological examination of protein marker combinations in hepatocellular carcinomas allowed the authors to propose an objective classification of these tumours according to their level of differentiation.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000276:immunology* / Q000473:pathology; D005982:Glutathione Transferase / Q000032:analysis; D008114:Liver Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013205:Staphylococcal Protein A / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D009363:Neoplasm Proteins; D013205:Staphylococcal Protein A; D000509:alpha-Fetoproteins; D005982:Glutathione Transferase
vernacular_title: Immunomorfologicheskiĭ amaliz urovnia differentsirovki gepatotselliuliarnykh opukholeĭ krys.