title: [Antiestrogens].
abstract: Antioestrogens are synthetic non-steroidal compounds which compete for oestrogen receptors. They induce a biological effect in various oestrogen target tissues in peripheral and central organs, but other mechanisms of action that do not involve oestrogen receptors are possible. Depending on the species and organ investigated, the biological effect may vary from pure antioestrogenic to pseudo-oestrogenic. Antioestrogens reduce the growth of oestrogen-dependent tumours in target organs or tissues which contain oestrogen receptors and are therefore successfully used in the treatment of hormone-dependent tumours, e.g. adenocarcinoma of the breast. They are generally well tolerated, but should be used with caution, owing to their endocrine side-effects. Combinations with other hormones to enhance their therapeutic effectiveness are currently being investigated.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D001943:Breast Neoplasms / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D004717:Endometrium / Q000187:drug effects; D004965:Estrogen Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D011960:Receptors, Estrogen / Q000187:drug effects; D011980:Receptors, Progesterone / Q000096:biosynthesis; D013629:Tamoxifen / Q000494:pharmacology
chemical_list: D004965:Estrogen Antagonists; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013629:Tamoxifen
vernacular_title: Les antiestrogènes.