Suppressor cell activity in progressive systemic sclerosis.
Prostaglandin-producing suppressor cell activity was significantly increased in patients with progressive systemic sclerosis (p less than .01). No significant differences were found in concanavalin-A induced suppressor T cell activity. Although these results indicate an alteration in immunoregulatory function they may represent a compensatory reaction to a defect in the regulation of fibrogenesis.
D000328:Adult; D000368:Aged; D003208:Concanavalin A / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D011453:Prostaglandins / Q000096:biosynthesis; D012595:Scleroderma, Systemic / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism
D011453:Prostaglandins; D003208:Concanavalin A