Influence of 2-mercaptopropionylglycine on DMBA-induced biochemical changes in regenerating mouse liver: I. Key enzymes of glycolysis and lactate dehydrogenase.
When the chemical carcinogen, DMBA, is administered by intragastric intubation to young adult female mice already subjected to partial hepatectomy, the glycolytic key enzymes (hexokinases, phosphofructokinase, pyruvate kinase) and lactate dehydrogenase show declined levels in the regenerating liver. But concomitant administration of MPG, a hepatotropic detoxicant, with DMBA either nullifies or minimizes the effect of the carcinogen on these enzymes.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D005260:Female; D006019:Glycolysis / Q000187:drug effects*; D006593:Hexokinase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008115:Liver Regeneration / Q000187:drug effects*; D051379:Mice; D010732:Phosphofructokinase-1 / Q000378:metabolism; D011770:Pyruvate Kinase / Q000378:metabolism; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D015127:9,10-Dimethyl-1,2-benzanthracene; D008625:Tiopronin; D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase