Specific LIF production in laryngeal cancer patients: evidence of suppressor activity exerted by adherent cells.
The specific tumor-induced LIF production in 30 laryngeal cancer patients has been investigated before and after the removal of adherent cells to evaluate the existence of a suppressor activity. LIF production, after challenging lymphocytes with 3 M KCI autologous tumor extracts, was significant in 16 patients and showed a further significant increase after removal of adherent cells. A conversion to significance when the adherent cells were removed was shown in 6 patients, with no previous significant LIF production. These data suggest the existence of a suppressor activity exerted by adherent cells on LIF production in laryngeal cancer patients.
D000951:Antigens, Neoplasm / Q000302:isolation & purification; D002448:Cell Adhesion; D002464:Cell Migration Inhibition; D002469:Cell Separation; D002478:Cells, Cultured; D006801:Humans; D007822:Laryngeal Neoplasms / Q000276:immunology*; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis* / Q000276:immunology; D008222:Lymphokines / Q000096:biosynthesis*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000951:Antigens, Neoplasm; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines