[Immunoallergic complication induced by rifampicin with disseminated intravascular coagulation].
In a 48-years old woman, intermittent rifampicin treatment induced an immunoallergic reaction with digestive disorders, haemolysis, acute renal failure and prolonged prothrombin time. The reintroduction of rifampicin, 17 days later, resulted in a similar, though more severe, reaction associated with diffuse haemorrhages from disseminated intravascular coagulation, this association being exceptional. The responsibility of rifampicin was demonstrated by the chronological relationship between clinical symptoms and administration of the drug, and by the presence in the patient's serum of anti-rifampicin antibodies. The antigen-antibody reaction with complement activation and haemolysis probably explains the disseminated intravascular coagulation.
D058186:Acute Kidney Injury / Q000139:chemically induced; D000906:Antibodies / Q000032:analysis; D000937:Antigen-Antibody Reactions; D003167:Complement Activation; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D012293:Rifampin / Q000009:adverse effects* / Q000276:immunology
D000906:Antibodies; D012293:Rifampin
Accident immunoallergique à la rifampicine avec coagulation intravasculaire disséminée.