Rat heart mitochondria release adenosine.
Isolated rat heart mitochondria release adenosine under specific conditions. Lowest adenosine release occurs at 4 degrees C while highest release occurs in the presence of pyruvate + malate or rotenone at 30 degrees C. The release is attenuated during state 3 respiration, in the presence of atractyloside or in the presence of 1799. Oligomycin only partially decreases adenosine release. Release is unaffected by 200 microM Ca++ and is independent of oxygen concentration as low as 2 microM. The data are consistent with the hypothesis that adenosine is released from mitochondria via the adenine nucleotide transporter and the release is regulated by the intramitochondrial ATP to ADP ratio.
D000241:Adenosine / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D066298:In Vitro Techniques; D008929:Mitochondria, Heart / Q000378:metabolism*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000226:Mitochondrial ADP, ATP Translocases; D000251:Adenosine Triphosphatases; D000241:Adenosine