Self- and allo-specific suppressor T cells evoked by intravenous injection of F protein.
The liver/serum protein F appears to inactivate clones reactive towards itself in the T helper cell but not the B cell compartment. To examine the extent of self-reactivity in the T suppressor cell compartment, the well-established procedure of i.v. injecting milligram doses of the protein was used. To detect suppression, an entirely in vitro proliferation assay was devised, based on use of immunopurified F antigen. In this way T suppressor cells could be detected after activation either by allogeneic F, or (though to a lesser extent) by self-F protein. Thus the T suppressor cell compartment contains potentially self-reactive clones, and to that extent the receptor repertoire of T suppressor cells overlaps with B rather than T helper cells.
D000818:Animals; D002455:Cell Division; D007165:Immunosuppression Therapy; D007275:Injections, Intravenous; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011506:Proteins / Q000008:administration & dosage*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D011506:Proteins