title: Alpha-methylene-gamma-lactone fused to steroidal ring D as potential antitumor agent.
abstract: Steroidal alpha-methylene-gamma-lactone la has been synthesised from 3 beta-hydroxy-5-androsten-17-one 2 and showed to be active against HeLa cells.
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000633:toxicity; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D007783:Lactones; D003687:Dehydroepiandrosterone