Effects of a single administration of 6-aminonicotinamide on hepatic microsomal drug metabolism in rats.
Pretreatment of rats with 6-aminonicotinamide (6-AN) induced a significant increase in aminopyrine (AM) N-demethylation and hexobarbital (HX) hydroxylation in rats. In this study, the concentrations of AM, 4-monomethylaminoantipyrine (MAA), aminoantipyrine (AA) and further metabolites were measured by using the GC/MS method. The increase in AM N-demethylation induced by 6-AN treatment was confirmed by measuring the area under the plasma concentration-time curve (AUC) for AM, MAA and AA in rats after AM administration. Of the first two steps of AM metabolism mediated by cytochrome P-450-coupled monooxygenase, the second step (from MAA to MA) was found to be more affected by 6-AN than the first one (from AM to MAA).
D015120:6-Aminonicotinamide / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D006591:Hexobarbital / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009536:Niacinamide / Q000031:analogs & derivatives*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D004364:Pharmaceutical Preparations; D009536:Niacinamide; D015120:6-Aminonicotinamide; D011189:Potassium Chloride; D006591:Hexobarbital; D006899:Mixed Function Oxygenases