[Hepatotoxicity of 2,4,5-trichlorophenoxyacetic acid. Cytologic and biochemical study in quail embryos].
The effects of 2,4,5-T on the hepatic cell in the 13 day old quail embryo have been studied. When injected at the dose level of 80 or 240 mg/kg into non-incubated eggs, this herbicide induces a proliferation of the smooth endoplasmic reticulum. The ergastoplasmic cisternae are dilated and feature a decrease in ribosomic covering. The mitochondria are swollen showing a pale matrix and a deficiency in cristae. One also observes an increase in the amount and size of lipidic inclusions and a dilatation of bile canaliculi. Moreover, biochemical analysis reveals a significant decrease in the glycogen content indicating that 2,4,5-T disturbs the glycogenic function of the liver.
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D003370:Coturnix; D008099:Liver / Q000187:drug effects* / Q000196:embryology / Q000648:ultrastructure; D008112:Liver Glycogen / Q000378:metabolism
D008112:Liver Glycogen; D015085:2,4,5-Trichlorophenoxyacetic Acid
Hépatotoxicité de l'acide 2,4,5-trichlorophénoxyacétique. Etude cytologique et biochimique chez l'embryon de caille.