[Suppressor T-lymphocytes in continuously progressive juvenile schizophrenia].
The study of T lymphocyte suppressors in juvenile continuously progressive schizophrenia showed that the number of suppressor cells in patients was significantly decreased as compared to a group of mentally normal donors; 20.4% and 28.9% respectively. The parallel study of the number of suppressor cells in the peripheral blood and the proliferative activity of T lymphocytes upon their stimulation with mitogenic lectins of PHA and Con A demonstrated that in the mentally normal donors, these parameters were inversely correlated, whereas in the patients with juvenile continuously progressive schizophrenia, there was no such correlation between the above indices. The data obtained are indicative of the impaired regulatory activity of T lymphocyte suppressors in this group of schizophrenic patients.
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D012559:Schizophrenia / Q000276:immunology*; D012563:Schizophrenia, Paranoid / Q000276:immunology; D012565:Schizophrenic Psychology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D010835:Phytohemagglutinins; D003208:Concanavalin A
T-limfotsity supressory pri iunosheskoĭ nepreryvno tekushcheĭ shizofrenii.