Structural heterogeneity of the C3b/C4b receptor (Cr 1) on human peripheral blood cells.
In these studies CR 1 polymorphism previously demonstrated on erythrocytes (E) was also found on CR 1-bearing peripheral blood leukocytes including polymorphonuclear (PMN), eosinophils, monocytes, and B lymphocytes. However several cell-specific differences in CR1 were found: (a) an approximately 5,000-dalton increase in CR 1 on PMN and eosinophils, (b) unequal band intensity among heterozygotes suggests that there is preferential expression of 220,000- or 225,000-dalton receptors on leukocytes compared to E, and (c) "minor" bands, approximately 15,000 daltons larger than the major receptor molecule, were found on E but not on leukocytes. These observations constitute a unique example of heterogeneity of an integral membrane receptor.
D001402:B-Lymphocytes / Q000032:analysis; D002462:Cell Membrane / Q000032:analysis; D002846:Chromatography, Affinity; D004804:Eosinophils / Q000032:analysis; D006801:Humans; D007163:Immunosorbent Techniques; D007962:Leukocytes / Q000032:analysis*; D008970:Molecular Weight; D009000:Monocytes / Q000032:analysis; D009504:Neutrophils / Q000032:analysis; D011110:Polymorphism, Genetic; D011951:Receptors, Complement / Q000235:genetics*; D017463:Receptors, Complement 3b
D011951:Receptors, Complement; D017463:Receptors, Complement 3b