[Comparative study of the effect of prolonged administration of nicotinic acid, nicotinamide and diethylnicotinamid (Cordiamin) on the rat liver monooxygenase system].
Nicotinic acid (50 mg/kg), nicotinamide (50 mg/kg) administered to rats intragastrically for 45 days do not exert any effect on the activity and the content of liver microsomal monooxygenase. Diethylnicotinamide (cordiamine) given in an equimolar dose (73 mg/kg) increases the microsomal content of cytochromes P-450 and b5, activates oxidoreductase of the components of the NADP X H-dependent redox-chain of the microsomal membranes, speeds up N-demethylation of amidopyrine and p-hydroxylation of aniline.
D000818:Animals; D003580:Cytochromes / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009536:Niacinamide / Q000008:administration & dosage*; D009539:Nicotinic Acids / Q000008:administration & dosage*; D009552:Nikethamide / Q000008:administration & dosage*; D051381:Rats; D013997:Time Factors
D003580:Cytochromes; D009539:Nicotinic Acids; D009536:Niacinamide; D009552:Nikethamide; D009247:NADH, NADPH Oxidoreductases
Sravnitel'noe izuchenie deĭstviia dlitel'nogo vvedeniia nikotinovoĭ kisloty, nikotinamida i diétilnikotinamida (kordiamina) na monooksigenaznuiu sistemu pecheni krys.