The role of protein kinase C in cell surface signal transduction and tumour promotion.
Protein kinase C has a crucial role in signal transduction for a variety of biologically active substances which activate cellular functions and proliferation. When cells are stimulated, protein kinase C is transiently activated by diacylglycerol which is produced in the membrane during the signal-induced turnover of inositol phospholipids. Tumour-promoting phorbol esters, when intercalated into the cell membrane, may substitute for diacylglycerol and permanently activate protein kinase C. The enzyme probably serves as a receptor for the tumour promoters. Further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002273:Carcinogens / Q000378:metabolism*; D002462:Cell Membrane / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D004789:Enzyme Activation; D007700:Kinetics; D008563:Membrane Lipids / Q000502:physiology; D010703:Phorbol Esters / Q000378:metabolism / Q000633:toxicity; D010743:Phospholipids / Q000502:physiology; D011493:Protein Kinase C; D011494:Protein Kinases / Q000378:metabolism*
D001095:Arachidonic Acids; D002273:Carcinogens; D008563:Membrane Lipids; D010703:Phorbol Esters; D010743:Phospholipids; D016718:Arachidonic Acid; D011494:Protein Kinases; D011493:Protein Kinase C; D002118:Calcium