title: A double-blind, randomized comparison of moxalactam versus clindamycin-gentamicin in treatment of endomyometritis after cesarean section delivery.
abstract: A double-blind comparison of clindamycin plus gentamicin versus moxalactam plus placebo was performed for the treatment of endomyometritis after cesarean section delivery. Entry criteria were uterine tenderness, temperature greater than or equal to 101 degrees F, and leukocytosis. Uterine specimens were obtained for culture via a single-lumen transcervical catheter. Bacteremia occurred in 10% of patients. Among the 57 patients treated with clindamycin plus gentamicin, there were two clinical failures and four side effect failures (diarrhea in two, allergic reaction in two). Among the 56 patients in the moxalactam group, there were four clinical failures and one side effect failure (diarrhea). Both regimens had good cure rates, with no significant differences in cures or postoperative hospital stay.
mesh_terms: D000328:Adult; D002511:Cephalosporins / Q000627:therapeutic use*; D002513:Cephamycins / Q000009:adverse effects / Q000627:therapeutic use*; D002585:Cesarean Section / Q000009:adverse effects*; D002981:Clindamycin / Q000008:administration & dosage* / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000139:chemically induced; D004311:Double-Blind Method; D004342:Drug Hypersensitivity / Q000209:etiology; D004359:Drug Therapy, Combination; D004716:Endometritis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D009070:Moxalactam; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy / Q000209:etiology; D011897:Random Allocation
chemical_list: D002511:Cephalosporins; D002513:Cephamycins; D005839:Gentamicins; D002981:Clindamycin; D009070:Moxalactam