Effects of maternal streptozotocin-diabetes on fetal growth, energy reserves and body composition of newborn pigs.
Two doses of Streptozotocin (50 and 100 mg/kg body weight) were administered to two groups of pregnant gilts at d 80 of gestation to determine the influence of two levels of maternal diabetes on the gilts, their developing progenies and the body composition of the pigs. All the experimental animals received 1.82 kg of gestation diet/day throughout gestation. Serum glucose concentration increased to hyperglycemic levels in low-dose and high-dose groups; insulin concentrations decreased (P less than .01) in the high-dose, but not in the low-dose group (P greater than .05). Maternal free fatty acids (FFA) increased (P less than .05) in both treatment groups when compared with the control. However, birth weight of the litter and litter size were not affected. The liver weight increased (P less than .01) in the progeny of high-dose but not the low-dose group. Total liver DNA and RNA were not altered by the treatments, however; total liver protein and protein:DNA ratio increased (P less than .01) in the progeny of high-dose gilts. Pigs from high-dose and low-dose groups showed increases (P less than .01) in liver glycogen concentrations and percentage liver lipid. Body chemical composition data showed increases in percentage dry matter and percentage lipid (P less than .05 and P less than .01, respectively) in the progeny of high-dose but not in the low-dose group. It was concluded that streptozotocin administered to gestating gilts increased the maternal nutrient supply to the developing pigs, which resulted in higher energy status of the pigs at birth.
D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D003921:Diabetes Mellitus, Experimental; D005314:Embryonic and Fetal Development; D004734:Energy Metabolism; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D013311:Streptozocin; D013552:Swine / Q000502:physiology*
D001786:Blood Glucose; D008112:Liver Glycogen; D013311:Streptozocin