Cefoperazone concentrations in human aqueous humor after intravenous administration.
Twenty-four patients about to undergo elective cataract surgery received either a 2-g (ten patients) or a 4-g (14 patients) intravenous infusion of cefoperazone one to six hours before surgery. The 4-g dose produced a mean peak aqueous humor concentration of 2.93 micrograms/ml at one hour; the mean concentration remained higher than 2 micrograms/ml for at least four hours. These levels, however, were never more than 90% of the minimum inhibitory concentration of cefoperazone for common bacterial ocular pathogens.
D001082:Aqueous Humor / Q000032:analysis*; D002387:Cataract Extraction; D002438:Cefoperazone; D002511:Cephalosporins / Q000008:administration & dosage / Q000032:analysis*; D006801:Humans; D007263:Infusions, Parenteral; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control
D002511:Cephalosporins; D002438:Cefoperazone