Replication-control functions block the induction of an SOS response by a damaged P1 bacteriophage.
UV-damaged bacteriophage P1 causes an SOS response in infected bacteria that can be measured colorimetrically with the aid of a lambda pL-lacZ fusion strain of Escherichia coli. This response is blocked by a P1 prophage. Evidence is offered that the blockage is caused by the concerted action of the incompatibility determinant incA and the immunity (c1 and c4) repressors of the prophage. We suggest that indirect induction of lambda by damaged P1 is caused by the abortive initiation of replication in either of two modes, one under incA control, the other under c1 control and indirectly (via ant, the determinant of a repression antagonist) under c4 control.
D010582:Bacteriophage lambda / Q000235:genetics; D003090:Coliphages / Q000235:genetics / Q000528:radiation effects*; D003124:Colorimetry; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics; D005814:Genes, Viral; D011938:Rec A Recombinases / Q000235:genetics; D014466:Ultraviolet Rays; D014775:Virus Activation
D011938:Rec A Recombinases