title: Protors--an integrated theory on the regulation of proliferation, oncogenesis, and aging.
abstract: Growth factors, chalones, mitogen and mitodepressive hormones, retine, promine and other compounds, controlling cellular multiplication are investigated separately at different fields of biomedicine. To promote their mutual research, integration and common nomenclature protor is suggested as collective term for the different regulators of proliferation. The coherent comprehension of protors offers a possibility to unified explanation of cell proliferation, oncogenesis, and ageing. Carcinogenesis takes place by lack of inhibitory, or overproduction of stimulatory protors, caused by somatic mutation of regulatory genes. Ageing is characterized or may be influenced by the altered concentration of protors in static, expanding and renewing populations.
mesh_terms: D000375:Aging; D002455:Cell Division / Q000187:drug effects; D006128:Growth / Q000187:drug effects; D006131:Growth Inhibitors; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D009626:Terminology as Topic
chemical_list: D006131:Growth Inhibitors; D006133:Growth Substances