Interactions between radioresistant T cells from plasmacytoma-bearing mice and radiosensitive T cells from normal mice leading to suppression.
Spleens from BALB/c mice bearing the plasmacytoma SPQC 11 contain a population of T cells capable of suppressing the production of antibodies when cultured with normal BALB/c splenocytes, but not with splenocytes from nude BALB/c mice. Inhibition was characteristically the most effective at low suppressor cell numbers using unirradiated T cells. Maximum suppression occurred when a radiosensitive population of T cells from normal mice interacted with a population of radioresistant T cells from plasmacytoma-bearing animals. Accurate characterization of the suppressor T cell activity required testing over a wide range of suppressor/indicator cell ratios. Suppressor activity was eliminated by treatment with anti-Thy 1.2 plus complement, was radioresistant and present over a full range of doses when irradiated cells were used.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D002450:Cell Communication; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006462:Hemolytic Plaque Technique; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010954:Plasmacytoma / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000502:physiology / Q000528:radiation effects