Successful treatment of acute dapsone intoxication using charcoal hemoperfusion.
A 22 year old female was admitted to hospital two hours after ingesting 4 g of dapsone. Over the next 15 h she developed progressive hemolysis and methemoglobinemia. Charcoal hemoperfusion and sequential dialysis were performed because of the serious risk of fatality following such a massive dose of dapsone. Charcoal hemoperfusion led to rapid clearing of dapsone from the circulation. This resulted in clinical improvement and controlled the progression of hemolysis and methemoglobinemia.
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D002606:Charcoal / Q000627:therapeutic use*; D003622:Dapsone / Q000097:blood / Q000506:poisoning*; D005260:Female; D006461:Hemolysis; D006464:Hemoperfusion; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced; D008708:Methemoglobinemia / Q000139:chemically induced; D006435:Renal Dialysis
D002606:Charcoal; D003622:Dapsone