The in vitro activity of moxalactam against 430 clinical, bacterial isolates.
The in vitro activity of the novel beta-lactam antibiotic moxalactam against 430 bacterial isolates was determined by an agar dilution method. Moxalactam was highly active against Enterobacteriaceae including indole-positive Proteus and Providencia, all isolates being susceptible to 1.0 microgram/ml or less. The drug was somewhat less active against Gram-positive cocci and Pseudomonas aeruginosa, and enterococci were highly resistant. All Haemophilus influenzae isolates were inhibited by 0.06 microgram/ml or less. Activity against Bacteroides fragilis was good but wide variations of minimal inhibitory concentrations were noted. Moxalactam may become a useful alternative to the aminoglycosides in the treatment of serious infections caused by Gram-negative bacteria.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009070:Moxalactam; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002513:Cephamycins; D009070:Moxalactam