Lymphocyte surface phenotypes in Down's syndrome.
The lymphocyte surface phenotypes in the blood of 7 non-institutionalized adults with trisomy-21, and in 10 karyotypically normal control subjects, were analysed by fluorescent microscopy with an OKT series of monoclonal antibodies. Whereas the proportions of OKT3+, OKT4+ and OKT6+ cells were similar in the two groups, the percentages of both OKT8+ and OKT10+ trisomic lymphocytes were significantly higher. The biological implications of these findings with respect to the underlying immunopathology of Down's syndrome are discussed.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D004314:Down Syndrome / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface