title: [Prophylaxis of patients with sensitization to chrome and nickel using a cosmetic preparation for topical use].
abstract: Firstly we showed the reason for the choice of each product used in the preparation of this cosmetic. After this we studied "in vitro" the effect of this preparation, and "in vivo" in 25 patients sensitive to Potassium dichromate. On seeing the null effect of this preparation, owing to the oxidation of ascorbic acid, on these 25 patients, we modified the formula, substituting the ascorbic acid and EDTA, respectively, for tartaric acid and glycine. The respective tests "in vitro" and "in vivo" on 20 patients, this time showed beneficial effect of this preparation in 60% of the patients tested. Of these 60%, a 25% have continue to work exposed to the allergen (dichromate or nickel) and the other 35% have continue working with lesions controlled by habitual topic therapy. This preparation can also be used, with less effect, for nickel.
mesh_terms: D000287:Administration, Topical; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D002857:Chromium / Q000009:adverse effects*; D003358:Cosmetics; D003877:Dermatitis, Contact / Q000209:etiology / Q000517:prevention & control*; D009783:Dermatitis, Occupational / Q000209:etiology / Q000517:prevention & control; D004492:Edetic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D009532:Nickel / Q000009:adverse effects*; D012828:Silicones / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D003358:Cosmetics; D012828:Silicones; D002857:Chromium; D009532:Nickel; D004492:Edetic Acid; D001205:Ascorbic Acid
vernacular_title: Profilaxis de los pacientes con sensibilización al cromo y al níquel con un preparado cosmético de utilización tópica.