Phagocytosis, peritoneal influx, and enzyme activities in peritoneal macrophages from germfree, conventional, and ex-germfree mice.
Peritoneal macrophages from germfree mice showed a higher basic activity of lysosomal enzymes than did macrophages from conventional mice, whereas oil-induced peritoneal influx, induction of lysosomal enzymes, and phagocytosis via the C3b receptor after endotoxin stimulation were reduced or absent. After germfree mice had been housed with conventional mice for 1 week, peritoneal influx and C3b receptor-mediated phagocytosis reached normal levels; after 4 weeks, enzyme activities also reached normal levels.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D005122:Exudates and Transudates / Q000166:cytology; D005856:Germ-Free Life; D005966:Glucuronidase / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000201:enzymology*; D051379:Mice; D010537:Peritoneum / Q000378:metabolism*; D010587:Phagocytosis; D011951:Receptors, Complement / Q000378:metabolism; D017463:Receptors, Complement 3b; D011961:Receptors, Fc / Q000378:metabolism
D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D011961:Receptors, Fc; D000135:Acid Phosphatase; D005966:Glucuronidase