Neocarzinostatin in cancer chemotherapy (review).
This article describes previous studies on a unique protein antitumor antibiotic, neocarzinostatin. Namely, its chemical nature, mode of action at molecular and cellular levels, toxicity and pharmacology, and recent results in clinical trials obtained primarily in Japan have been reviewed briefly.
D000595:Amino Acid Sequence; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004273:DNA, Neoplasm / Q000378:metabolism; D004285:Dogs; D004341:Drug Evaluation; D006801:Humans; D007928:Lethal Dose 50; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D009353:Zinostatin / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D009353:Zinostatin