[Effect of L-tryptophan, nicotinamide, L-methionine and 1-methylnicotinamide on the embryotoxic effect of various substances].
There are several reports in the literature indicating that embryotoxic substances influence the nicotinamide adenine dinucleotide (NAD) metabolism. Therefore, the effect of different metabolites of the NAD metabolism--i.e. nicotinamide, L-tryptophan, 1-methylnicotinamide as well as L-methionine - upon the embryotoxicity of 6-aminonicotinamide, hydroxy-urea, 6-mercaptopurine, and cyclophosphamide was studied. 1. The embryotoxicity of 6-aminonicotinamide is completely prevented by nicotinamide and L-tryptophan, but enhanced by L-methionine and 1-methylnicotinamide. 2. Hydroxy-urea produced a resorption rate of 30% of the fetuses under the conditions applied. In the presence of L-methionine, the rate is lower; the other substances do not show any effect. 3. All substances used enhance the embryotoxicity of 6-mercaptopurine. There are, however, marked differences between them. 4. The embryotoxicity of cyclophosphamide is especially enhanced by a combined administration of nicotinamide + L-methionine. L-Tryptophan, on the other hand, increases the weight of the embryos.
D015120:6-Aminonicotinamide / Q000633:toxicity; D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity; D004347:Drug Interactions; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D006918:Hydroxyurea / Q000633:toxicity; D015122:Mercaptopurine / Q000633:toxicity; D008715:Methionine / Q000494:pharmacology*; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011247:Pregnancy; D014364:Tryptophan / Q000494:pharmacology*
D009536:Niacinamide; D015120:6-Aminonicotinamide; D014364:Tryptophan; D003520:Cyclophosphamide; D008715:Methionine; D015122:Mercaptopurine; C024058:N(1)-methylnicotinamide; D006918:Hydroxyurea
Einfluss von L-Tryptophan, Nikotinsäureamid, L-Methionin und 1-Methylnikotinsäureamid auf die embryotoxische Wirkung verschiedener Substanzen.