title: Spinal cord acetylcholine content: the consequence of transection or treatment with the neurotoxin 6-aminonicotinamide.
abstract: The distribution of choline (Ch) and acetylcholine (ACh) within the rat spinal cord was found to be rather uniform with values for Ch of about 280 pmol/mg protein and for ACh of about 250 pmol/mg protein. Cord transection at the T10-11 level did not reduce ACh below the lesion but there was about a 30% decrease of ACh in the thoracic region suggesting the presence of cholinergic fibers that ascend and terminate within the cord. Treatment of rats with the neurotoxin 6-aminonicotinamide resulted in spastic hindlimb paralysis and a loss of ACh in the lumbar region of the cord.
mesh_terms: D015120:6-Aminonicotinamide / Q000494:pharmacology*; D000109:Acetylcholine / Q000032:analysis*; D000818:Animals; D002794:Choline / Q000032:analysis; D002799:Cholinergic Fibers; D002818:Cordotomy; D005727:Ganglia, Spinal / Q000032:analysis; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000032:analysis* / Q000166:cytology; D013126:Spinal Nerve Roots / Q000032:analysis
chemical_list: D009536:Niacinamide; D015120:6-Aminonicotinamide; D002794:Choline; D000109:Acetylcholine