Effects of ultraviolet irradiation on epidermal Langerhans cells in guinea-pigs.
There is good evidence to suggest that u.v. irradiation (UVB) of the skin causes a reduction in the numbers of normal epidermal Langerhans cells (LC) in man and mouse. Little information is available on the effects of u.v. radiation on LC in guinea-pig skin. In this study, different dosages of UVB and UVC were applied to the ear skin of guinea-pigs. UVC irradiations were found more effective than UVB in causing depletions of ATPase-positive epidermal LC. Highly significant depletions, lasting 6 days after irradiation, were produced with little evidence of significant inflammatory reactions occurring in the epidermis.
D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology / Q000473:pathology; D006168:Guinea Pigs; D007801:Langerhans Cells / Q000201:enzymology / Q000528:radiation effects*; D008297:Male; D012867:Skin / Q000473:pathology; D014466:Ultraviolet Rays
D000251:Adenosine Triphosphatases