T lymphocyte abnormalities in disseminated histoplasmosis.
Disseminated histoplasmosis is associated with depression of T cell-mediated immunity and in some cases anergy. In this report, two patients with disseminated disease are described. Both had a depression of T cell-mediated immunity as well as other abnormalities of immune response. In one, a patient with relapse, a marked depression in the ratio of T helper to T suppressor cells was noted. Neither patient had any predisposing condition known to be associated with disseminated disease.
D000328:Adult; D003601:Cytotoxicity Tests, Immunologic; D006660:Histoplasmosis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology