Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
Two series of amidine derivatives consisting of a total of 24 compounds were examined for a correlation between their blocking effect on respiratory syncytial virus induced cell fusion and their inhibitory activity against selected trypsin-like protease. Although no correlation was evident between the two activities, several potentially important discoveries were made. A highly selective inhibitor of plasmin over thrombin (compound 10) was obtained, and a potent new blocker of virus-induced cell fusion (compound 22) was identified.
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002459:Cell Fusion / Q000187:drug effects; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D008114:Liver Neoplasms, Experimental / Q000503:physiopathology; D011480:Protease Inhibitors; D051381:Rats; D012136:Respiratory Syncytial Viruses / Q000187:drug effects / Q000502:physiology*; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors*
D000578:Amidines; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D013917:Thrombin; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator