Renal effects of a synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) in anesthetized dogs.
The effects of a synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) on renal hemodynamics and urine formation were investigated in anesthetized dogs. Intrarenal arterial infusion of the peptide (1.0 microgram/min) increased renal blood flow, glomerular filtration rate and urine flow with no change in systemic blood pressure. A lower dose of alpha-hANP (0.2 micrograms/min) produced a significant diuresis and natriuresis, while renal hemodynamics remained unchanged. The urinary excretion of Na, Cl and Ca was increased in proportion to the urine flow. We propose that alpha-hANP inhibits tubular reabsorption of electrolytes, and in higher dose produces renal vasodilation.
D000758:Anesthesia; D000818:Animals; D009320:Atrial Natriuretic Factor; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004573:Electrolytes / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009124:Muscle Proteins / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects
D004573:Electrolytes; D009124:Muscle Proteins; D009320:Atrial Natriuretic Factor