title: Treatment of simple urinary tract infections in general practice with a 3-day course of norfloxacin.
abstract: Ninety-nine patients with simple symptomatic urinary tract infections from three general practices were treated with norfloxacin 400 mg bd for 3 days and were followed up for 2 to 4 weeks. Forty of the 99 patients had bacteriuria. Bacteriological eradication of initial pathogen was achieved by 5 to 7 days in 100%. At 2 to 4 weeks three patients had become reinfected but with a different organism. Ninety per cent of patients were symptomatically cured or improved by the fifth to seventh day after therapy started. Drug related adverse experiences were seen in 9% of patients. None necessitated cessation of therapy. No significant biochemical or haematological abnormalities occurred.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D001437:Bacteriuria / Q000382:microbiology; D002648:Child; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D009268:Nalidixic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009643:Norfloxacin; D013997:Time Factors; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000892:Anti-Infective Agents, Urinary; D009268:Nalidixic Acid; D009643:Norfloxacin