[Fibrinolytic action of an enzyme preparation conjugated with specific antibodies].
The authors have modified alpha-chymotrypsin covalently bound via aldehyde dextran with polyclonal antibodies to fibrinogen. Modification does not lead to any substantial changes in the catalytic properties of the enzymes or to appreciable losses in specific activity of antibodies. At the same time in experimental thrombolysis in vitro, the derivatives obtained exhibit a higher fibrinolytic action as compared with control preparations. It is assumed that the effect observed is accounted for by an increase in tropism of the conjugate obtained to the fibrin clot.
D000906:Antibodies; D000918:Antibody Specificity; D002384:Catalysis; D002918:Chymotrypsin / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology; D004338:Drug Combinations; D005340:Fibrinogen / Q000276:immunology*; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents; D066298:In Vitro Techniques
D000906:Antibodies; D003911:Dextrans; D004338:Drug Combinations; D005343:Fibrinolytic Agents; D005340:Fibrinogen; D002918:Chymotrypsin
Fibrinoliticheskoe deĭstvie fermentnogo preparata, kon"iugirovannogo so spetsificheskimi antitelami.