Acute interstitial pneumonitis and carbamazepine therapy.
A 14-year-old girl with skin rash and acute interstitial pneumonitis is presented. She had been taking carbamazepine for two months. Withdrawal of carbamazepine resulted in a prompt improvement of the clinical picture and a normalization of lung function tests. A hypersensitivity reaction to carbamazepine is suggested and the importance of a skin rash as first sign of a generalized reaction is stressed. Lymphocyte-stimulation-tests with carbamazepine were strongly positive in the patient and not in healthy persons nor in patients taking carbamazepine without adverse effects.
D000293:Adolescent; D002220:Carbamazepine / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008213:Lymphocyte Activation; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
D002220:Carbamazepine