A case report of T-cell lymphoma with suppressor phenotype and helper function for immunoglobulin synthesis.
A patient with T-cell lymphoma is presented. The morphologic features of a biopsied lymph node were consistent with adult T-cell lymphoma with hypergammaglobulinemia, and most of the lymph node cells were reactive with monoclonal antibody OKT8, which detects suppressor/cytotoxic T lymphocytes. However, in a pokeweed mitogen-driven test system in which the capability of T lymphocytes to help or suppress the differentiation of B lymphocytes is measured, the lymphoma cells induced immunoglobulin synthesis of B lymphocytes, thus providing helper function. As far as we know, this is the first report on T-cell lymphoma having suppressor phenotype and helper function for immunoglobulin synthesis.
D000911:Antibodies, Monoclonal; D000917:Antibody Formation; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D006801:Humans; D008211:Lymphocyte Cooperation; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface