[Cell division and changes of the duration of mitosis in murine Ehrlich ascites carcinoma after a single administration of chalone-containing extract from this tumor].
Single injection of chalone-containing extract from Ehrlich's ascites carcinoma leads to the occurrence of the three phases in the status of cell reproduction system in the carcinoma: inhibition, stimulation (synchronization) and normalization of the number of mitoses. Injection of the preparation during the period of a higher mitotic activity in the controls results in a less marked (57.1%) and less prolonged (5 h) inhibition of cell division in the carcinoma than administration in the period of low cell proliferation (inhibition 86.4% and 82.5% while its duration 9 h). The existence of the three phases in the changes occurring in cell division after a single exposure to the chalone-containing preparation, including the phase of relative synchronization of cell reproduction has been confirmed by studying the time course of K mitoses. During the cell division inhibition phase the mitosis duration increases 1.5-4.5-fold.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000032:analysis / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D006131:Growth Inhibitors / Q000008:administration & dosage* / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D013997:Time Factors
D006131:Growth Inhibitors
Kletochnoe delenie i izmeneniia prodolzhitel'nosti mitoza v astsitnoĭ opukholi Erlikha mysheĭ posle odnokratnogo vozdeĭstviia keĭlonsoderzhashchim ékstraktom iz étoĭ opukholi.