title: Resistance of human tumor cell lines to antifolates.
mesh_terms: D001402:B-Lymphocytes / Q000187:drug effects; D001692:Biological Transport / Q000187:drug effects; D002460:Cell Line; D004351:Drug Resistance; D005492:Folic Acid / Q000627:therapeutic use / Q000031:analogs & derivatives; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D006801:Humans; D007621:Karyotyping; D008727:Methotrexate / Q000627:therapeutic use; D012516:Osteosarcoma / Q000188:drug therapy; D011739:Pyrimethamine / Q000031:analogs & derivatives / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000187:drug effects; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D016597:Trimetrexate
chemical_list: D005493:Folic Acid Antagonists; D011799:Quinazolines; C006308:metoprine; C100117:homofolic acid; C031662:CB 3717; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D016597:Trimetrexate; D008727:Methotrexate; D011739:Pyrimethamine