Comparative effects of moxalactam and gentamicin on human polymorphonuclear leukocyte functions.
The in vitro effects of moxalactam and gentamicin on chemotactic, phagocytic, and microbicidal activities of human polymorphonuclear leukocytes have been studied. Incubation of cells with moxalactam (25 to 400 micrograms/ml) resulted in a 10 to 15% inhibition of leukocyte chemotaxis (P less than or equal to 0.10). Incubation of cells with gentamicin (5 to 40 micrograms/ml) inhibited chemotaxis more than 50% (P less than or equal to 0.50). Neither moxalactam nor gentamicin had any effect on phagocytic or microbicidal capacities of leukocytes.
D002464:Cell Migration Inhibition; D002511:Cephalosporins / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009070:Moxalactam; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects
D002511:Cephalosporins; D002513:Cephamycins; D005839:Gentamicins; D009070:Moxalactam