[L and M isoenzymes of hepatic pyruvate kinase and their hormone dependence].
By immunofluorescence and double labelled anti sera L and M pyruvate kinase, there is a double localization of isozymes. It is detected in basal state, in vitro, in isolated hepatocyte, in vivo in experimental or genetic (Zucker rat) hyperinsulinemia or in regenerating liver following partial hepatectomy. It is found in hepatology, in regenerative nodule of cirrhosis and in cancerous cells of liver. This double presence of L and MPK tallies with a specific double hormonodependence: induction of MPK by insulin, and inhibition of LPK by glucagon.
D000818:Animals; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007527:Isoenzymes / Q000032:analysis*; D008099:Liver / Q000201:enzymology*; D008103:Liver Cirrhosis / Q000201:enzymology; D008113:Liver Neoplasms / Q000201:enzymology; D008115:Liver Regeneration; D008297:Male; D011770:Pyruvate Kinase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011924:Rats, Zucker
D007328:Insulin; D007527:Isoenzymes; D005934:Glucagon; D011770:Pyruvate Kinase
Isozymes L et M de la pyruvate kinase hépatique et hormono-dépendance.