[Role of the monocytes and IgG in the development of atherosclerotic lesions in the aorta of rabbits].
In experimental hypercholesterinemia in rabbits, immune autoradiographic studies showed that lesions in the endothelial monolayer of the aorta developed in parallel with IgG deposition in the cytoplasm of the affected endothelial cells and in different parts of atherosclerotic plaques. This process was accompanied by active replacement of blood monocytes into the internal sheath of the aorta in the zone of IgG deposition which appeared to be due to the presence in these cells of Fc-receptors for immunoglobulins. Incomplete catabolism of lipids in the cytoplasm of macrophages of monocytic genesis is one of the key events of atherosclerosis morphogenesis.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D001018:Aortic Diseases / Q000209:etiology*; D001161:Arteriosclerosis / Q000209:etiology*; D007105:Immune Complex Diseases / Q000209:etiology*; D007074:Immunoglobulin G / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000276:immunology; D009000:Monocytes / Q000276:immunology*; D011817:Rabbits; D011961:Receptors, Fc / Q000276:immunology
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; D011961:Receptors, Fc
Rol' monotsitov krovi i IgG v razvitii ateroskleroticheskikh porazheniĭ aorty u krolikov.