Crown ethers which influence cardiac and respiratory muscle contractility.
Guinea-pig tracheal smooth muscle and heart muscle demonstrated a variety of in vitro positive and negative inotropic responses to concentrations of crown ethers in the nmole/1 to mumole/1 range. It is suggested that these ionophoretic compounds have potential as therapeutic agents.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004988:Ethers, Cyclic / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007476:Ionophores / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014132:Trachea
D004988:Ethers, Cyclic; D007476:Ionophores