A homopolymer of the potent antitumor drug 2'-deoxy-5-fluorouridylate.
Poly(5-fluoro-2'-deoxyuridylic acid) was synthesized and its properties were compared with those of poly(dT) and poly(dU). It readily complexed with poly(dA). The 1:1 complex melted at about 20 degrees C lower than poly(dA) . poly(dT). A triple-stranded helix, poly(dA) . 2 poly(dF5U) was formed only in high salt (2.0 M NaCl).
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D005467:Floxuridine / Q000031:analogs & derivatives*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D011061:Poly A; D011072:Poly U / Q000138:chemical synthesis*; D011089:Polydeoxyribonucleotides
D011089:Polydeoxyribonucleotides; D005467:Floxuridine; D011061:Poly A; D011072:Poly U; C040119:poly(5-fluoro-2'-deoxyuridylic acid)