Influence of long-term zimelidine treatment on LSD-induced behavioural effects.
The effect of lysergic acid diethylamide (LSD) on copulatory and exploratory behaviour in hormone-treated, ovariectomized rats was investigated 4 weeks after chronic treatment with either saline or zimelidine (ZIM). A decrease in sensitivity to the lordosis-inhibiting effect of LSD was observed in the group treated with ZIM. The two groups also differed in their reaction to LSD in the exploratory test. The ZIM-treated animals seemed to be less sensitive to LSD. We therefore suggest that long-term treatment with ZIM reduces the sensitivity of the postsynaptic serotonin receptor.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003307:Copulation / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D015031:Zimeldine / Q000494:pharmacology*
D015031:Zimeldine; D011374:Progesterone; D004958:Estradiol; D008238:Lysergic Acid Diethylamide