Protective effect of nicotinamide on bracken fern induced carcinogenicity in rats.
Albino noninbred weanling male and female rats were fed a basic grain diet (Group 1), a basic diet supplemented with 0.5% nicotinamide (Group 2), a basic diet containing 33% bracken fern (BF) (Group 3), or a basic diet supplemented with 33% BF and 0.5% nicotinamide (Group 4) for 58 weeks. Dietary nicotinamide decreased the BF-induced incidence of both intestinal and bladder tumorigenesis by about 40%. The inhibitory effect of nicotinamide on the BF-induced intestinal and bladder tumors was significant at p less than 0.05 and p less than 0.01, respectively.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007414:Intestinal Neoplasms / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D009243:NAD / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000209:etiology / Q000517:prevention & control; D009536:Niacinamide / Q000627:therapeutic use*; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000517:prevention & control*
D009243:NAD; D009536:Niacinamide