title: Double-blind study of effects of enkephalinase inhibitor on adverse reactions to myelography.
abstract: The side effects in myelography are well known and frequently observed. The most common are headache, nausea, and vomiting. In this study, a rather new compound, Thiorphan, was examined, which displays an antinociceptive activity by inhibiting enkephalinase activity. Forty-two patients received intravenous infusions of Thiorphan before myelography. Another 42 patients were in a control group, and Thiorphan was not administered. In the treated group, postmyelographic headache was found in 24% (versus 52% in the control group). Nausea and vomiting were never seen. Low back pain or sciatica was diminished in 33% of cases. Enkephalin levels in cerebrospinal fluid were measured by a radioreceptor-assay method in both groups without any correlation.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D001416:Back Pain / Q000517:prevention & control; D004311:Double-Blind Method; D005260:Female; D006261:Headache / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D009192:Myelography / Q000009:adverse effects*; D009325:Nausea / Q000517:prevention & control; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012585:Sciatica / Q000517:prevention & control; D015244:Thiorphan; D008625:Tiopronin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D014839:Vomiting / Q000517:prevention & control
chemical_list: D000603:Amino Acids, Sulfur; D011480:Protease Inhibitors; D015244:Thiorphan; D008625:Tiopronin