Lisuride, LY-141865, and 8-OH-DPAT facilitate male rat sexual behavior via a non-dopaminergic mechanism.
In agreement with previous results from this laboratory, the ergot derivative lisuride (0.4 mg/kg IP) and the ergot congener 8-OH-DPAT (0.25 mg/kg IP) produced a marked facilitation of male rat sexual behavior. Furthermore, another ergot compound, the dopamine-2 selective agonist LY-141865 (2.5-20 mg/kg IP), was shown to facilitate male rat sexual behavior to the same degree. Neither the effects produced by LY-141865, nor the effects produced by lisuride or 8-OH-DPAT, were antagonized by pretreatment with the dopamine receptor blocking agent haloperidol, 0.16 mg/kg IP. A higher dose of haloperidol (0.32 mg IP), which produced clear extrapyramidal symptoms, was also ineffective in antagonizing the lisuride- or 8-OH-DPAT-induced facilitation of male rat sexual behavior. It is concluded that the stimulation of male rat sexual behavior produced by ergot and ergot-like drugs is mediated via a non-dopaminergic mechanism.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D004873:Ergolines / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008090:Lisuride / Q000494:pharmacology*; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D004873:Ergolines; D009281:Naphthalenes; D011954:Receptors, Dopamine; D013764:Tetrahydronaphthalenes; D019257:Quinpirole; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D008090:Lisuride; D006220:Haloperidol