[Effect of glucocorticoids on the formation of methemoglobin in rats].
Experiments on rats showed that treatment of rat with hydrocortisone, dexamethasone and diplacin for 14 days increases the content of methemoglobin in blood. In vitro experiments revealed that dexamethasone in a concentration of 10(-6) M increased the amount of methemoglobin in the whole blood and did not change its amount in hemolysate. The data obtained show the participation of erythrocyte membranes in methemoglobin-forming effect of the studied substances.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008706:Methemoglobin / Q000096:biosynthesis*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D003473:Neuromuscular Nondepolarizing Agents; D011763:Pyrrolizidine Alkaloids; C004268:diplacin; D003907:Dexamethasone; D008706:Methemoglobin; D006854:Hydrocortisone
Vliianie gliukokortikoidov na obrazovanie metgemoglobina u krys.