title: Nitrogen regulation of amino acid utilization by Neurospora crassa.
abstract: The production of an extracellular deaminase activity involved with the utilization of amino acids as sole sources of nitrogen is under the control of the nit-2 locus of Neurospora crassa. This locus is the sole major nitrogen regulatory locus described for N. crassa and is believed to encode a positive effector required for induction of activities involved with the utilization of alternate nitrogen sources. Production of deaminase activity requires the lifting of nitrogen metabolite repression, the presence of a functional nit-2 gene product, and specific induction by amino acids. Additional parameters of enzyme production are described.
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000619:Aminohydrolases / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D005796:Genes; D005800:Genes, Fungal; D007700:Kinetics; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000254:growth & development / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D000596:Amino Acids; D000619:Aminohydrolases; D009584:Nitrogen