The possible role of bradykinin as a mediator in bronchial asthma.
A variety of antiasthmatic drugs were examined in a bioassay of uterine cornua of rats for determining their influence upon Bradykinin induced contractions. 4 different actions were seen: pronounced, moderate and weak suppression of enhancement of Bradykinin-activity. The most pronounced blocking effect was seen with Fenoterol, Adrenaline and Pheniramine, a moderate effect with Prednisolone and Tolazoline, a weak effect with Propranolol and DSCG. Noradrenaline showed a stimulating effect. It is postulated that Bradykinin acts via alpha-stimulation with concomitant cAMP-decrease after specific binding to Bradykinin-receptors. The results of the study suggest that Bradykinin still must be discussed as a possible mediator in obstructive airway-disease.
D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D001681:Biological Assay; D001920:Bradykinin / Q000037:antagonists & inhibitors / Q000502:physiology*; D004205:Cromolyn Sodium / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005280:Fenoterol / Q000494:pharmacology; D009241:Ipratropium / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010632:Pheniramine / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D014043:Tolazoline / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects
D010632:Pheniramine; D005280:Fenoterol; D011239:Prednisolone; D011433:Propranolol; D014043:Tolazoline; D009241:Ipratropium; D004205:Cromolyn Sodium; D001920:Bradykinin; D009638:Norepinephrine; D004837:Epinephrine