title: Identification of a gene regulating the tissue expression of a phosphoglucomutase locus in rainbow trout.
abstract: Nine percent of the rainbow trout (Salmo gairdneri) from a hatchery source have a greater than 100-fold increase in expression of a phosphoglucomutase (PGM) locus, Pgm1, in the liver but have normal expression of this locus in other tissues. The results of genetic crosses are consistent with a single regulatory gene with additive inheritance being responsible for the differences in the amount of PGM activity in the liver.--The allele responsible for the expression of Pgm1 in the liver is apparently a recent mutation. This is supported by its restricted distribution in rainbow trout and the absence of liver Pgm1 expression in closely related species. This genetic system is valuable for future analysis of the control of gene expression and in determining the relative evolutionary importance of genetic variation at structural and regulatory genes.
mesh_terms: D000818:Animals; D005809:Genes, Regulator; D014644:Genetic Variation; D008099:Liver / Q000201:enzymology; D009132:Muscles / Q000201:enzymology; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics* / Q000378:metabolism; D012487:Salmonidae / Q000235:genetics*; D014018:Tissue Distribution; D014337:Trout / Q000235:genetics*
chemical_list: D010733:Phosphoglucomutase