Predictive factors for bleomycin-induced pneumonitis.
Five pulmonary function tests (transfer factor for carbon monoxide, diffusing capacity of the alveolar-capillary membrane, pulmonary capillary blood volume, alveolar volume, vital capacity) were performed, and creatinine clearance was measured in 39 patients with disseminated testicular nonseminomatous tumor treated with a combination chemotherapy containing bleomycin. Eight of these patients (20.5%) developed bleomycin-induced pneumonitis (BIP). To investigate which parameter has value in predicting BIP, a discriminant analysis was performed. The combination of a low normal creatinine clearance, a decrease in vital capacity and alveolar volume without a decrease in pulmonary capillary blood volume, pointed to an increased risk. We concluded that it is worthwhile to monitor these parameters and, if necessary, to adapt the chemotherapy of a patient at risk.
D000293:Adolescent; D000328:Adult; D001761:Bleomycin / Q000009:adverse effects*; D001810:Blood Volume; D002196:Capillaries; D002277:Carcinoma / Q000188:drug therapy; D003404:Creatinine / Q000378:metabolism; D005544:Forecasting; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000453:epidemiology; D011650:Pulmonary Alveoli; D011859:Radiography; D013223:Statistics as Topic; D013736:Testicular Neoplasms / Q000188:drug therapy; D014797:Vital Capacity
D001761:Bleomycin; D003404:Creatinine