title: Effect of dehydroepiandrosterone on hereditary angioedema.
abstract: Hereditary angioneurotic edema (HAE) is a complement-related clinical disorder with a deficiency of the C1 esterase inhibitor protein. Eight patients with severe attacks of the disease were treated with the adrenal "androgen" dehydroepiandrosterone sulphate (DS). Steroid therapy for 3-28 months resulted in dramatic improvement in their clinical state and a moderate increase in the serum concentration of C1 inhibitor. There was a significant increase in the serum level of either unconjugated dehydroepiandrosterone (D) or of DS during treatment.
mesh_terms: D000293:Adolescent; D000328:Adult; D000799:Angioedema / Q000188:drug therapy* / Q000235:genetics; D003181:Complement C4 / Q000032:analysis; D003169:Complement Inactivator Proteins / Q000097:blood; D003687:Dehydroepiandrosterone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003181:Complement C4; D003169:Complement Inactivator Proteins; D003687:Dehydroepiandrosterone