[Penetration of mezlocillin and oxacillin into the glandular and adipose tissue of the breast after simultaneous intravenous infusion. A pharmacokinetic study].
The concentrations of mezlocillin and oxacillin were measured after simultaneous intravenous infusion of 4 and 2 g respectively in serum, fat and mammary gland tissue of 35 patients. The maximum mean concentrations of mezlocillin were measured in serum with 281 micrograms/ml and in fat with 38 micrograms/g after the end of the infusion and in the mammary gland with 52.3 micrograms/g after 90 minutes. Mezlocillin concentrations of less than or equal to 2.0 micrograms/ml and g respectively were found after 6-8 hours after the end of the infusion. The maximum mean concentrations of oxacillin were measured in the serum with 107.8 micrograms/ml also after the end of the infusion, declining to levels less than or equal to 2.0 micrograms/ml within 6 hours. Measurable oxacillin-concentrations could not be found in the fat and in the tissue of mammary gland with the chosen dose. The clinical relevance of the results is discussed.
D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001940:Breast / Q000378:metabolism*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008408:Mastectomy; D008802:Mezlocillin; D008875:Middle Aged; D010068:Oxacillin / Q000008:administration & dosage / Q000378:metabolism*; D010406:Penicillins / Q000008:administration & dosage / Q000378:metabolism*; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care; D014018:Tissue Distribution
D004338:Drug Combinations; D010406:Penicillins; D008802:Mezlocillin; D010068:Oxacillin
Penetration von Mezlozillin und Oxazillin in das Brustdrüsen- und Fettgewebe nach intravenöser Simultaninfusion. Eine pharmakokinetische Untersuchung.