title: [Biochemical processes on membranes during lymphocyte stimulation].
abstract: A conformational change of the antigen receptors takes place with the help of macrophages, T helper cells and soluble factors after antigen binding. This conformational change may result in the following reactions: a) activation of a receptor-associated enzyme system b) influence on the lipid matrix and indirect activation of membrane-associated enzyme systems or influence on the cell metabolism by changing the ion flux c) activation of the cytoskeleton with following movements of the ligand-receptor-complexes and indirect activation of cytoskeleton-associated enzyme systems or influence on the metabolism by changing the ion flux. The adenylate cyclase (phosphorylating cascade) or the proteases (limited proteolysis of inactive proenzymes) may be the enzyme systems with regulatory effect which can be activated.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D003078:Colchicine / Q000494:pharmacology; D003572:Cytochalasins / Q000494:pharmacology; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007152:Immunologic Capping; D008213:Lymphocyte Activation; D008934:Mitogens / Q000276:immunology; D008938:Mitosis / Q000187:drug effects; D011946:Receptors, Antigen / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D011975:Receptors, Mitogen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D003572:Cytochalasins; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II; D008934:Mitogens; D011946:Receptors, Antigen; D011947:Receptors, Antigen, B-Cell; D011975:Receptors, Mitogen; D014747:Vinblastine; D003078:Colchicine
vernacular_title: Biochemische Vorgänge an der Membran bei der Lymphozytenstimulierung.