The influence of short-duration stretch on vasoconstrictor response in rabbit aortas.
Circumferential strips of rabbit aorta were subjected to 60-second graded stretches in vitro. Before and after each stretch, the vasoconstrictor dose-responses to potassium and norepinephrine were measured. For stretch between 130 to 190% of resting length, vasoconstrictor response was progressively enhanced. However, arteries stretched 190 to 220% of resting length showed a significant fall in developed tension in response to either vasoconstrictor. Since arteries in vivo operate at 150 to 180% of resting length due to physiologic distention, it is likely that effective angioplasty does induce paralysis of vascular smooth muscle.
D000800:Angioplasty, Balloon / Q000009:adverse effects; D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D011817:Rabbits; D013314:Stress, Mechanical; D013997:Time Factors; D014661:Vasoconstriction / Q000187:drug effects*
D011188:Potassium; D009638:Norepinephrine