Heterogeneity of bone marrow-directed immune mechanisms in the pathogenesis of neutropenia of Felty's syndrome.
Twenty-seven patients with Felty's syndrome were studied by the colony forming unit in culture (CFU-C) assay for possible immune mechanisms within the bone marrow compartment that could contribute to the neutropenia. Depletion of bone marrow suppressor T cells resulted in normal CFU-C numbers in 7 patients. In 5 patients serum antiprecursor cell activity was detected. Blood monocytes failed to generate colony stimulating factor in 5 patients. Bone marrow-directed immune mechanisms are heterogeneous and could play a role in the pathogenesis of neutropenia in some patients with Felty's syndrome.
D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000209:etiology*; D000920:Antibody-Dependent Cell Cytotoxicity; D000936:Antigen-Antibody Complex / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology*; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D005258:Felty Syndrome / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology* / Q000503:physiopathology; D050378:T-Lymphocytes, Regulatory / Q000503:physiopathology
D000936:Antigen-Antibody Complex; D003115:Colony-Stimulating Factors