Monocytes and platelets share the glycoproteins IIb and IIIa that are absent from both cells in Glanzmann's thrombasthenia type I.
By means of an antiserum specific to the complex of the platelet membrane glycoproteins IIb and IIIa we demonstrate here that monocytes and purified monocyte membranes share these glycoproteins with platelets. The monocyte glycoprotein IIb-IIIa complex showed complete immunological identity with the platelet counterpart and, furthermore, dissociated after EDTA treatment exactly as did the platelet complex. In Glanzmann's thrombasthenia type I, monocytes as well as platelets lack this antigen completely.
D000954:Antigens, Surface / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006023:Glycoproteins / Q000097:blood* / Q000276:immunology; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D008565:Membrane Proteins / Q000097:blood / Q000276:immunology; D009000:Monocytes / Q000276:immunology / Q000378:metabolism*; D010980:Platelet Membrane Glycoproteins; D011696:Purpura, Thrombocytopenic / Q000097:blood* / Q000276:immunology
D000954:Antigens, Surface; D006023:Glycoproteins; D008565:Membrane Proteins; D010980:Platelet Membrane Glycoproteins