Evidence of serotonin involvement in the effect of morphine on dopamine metabolism in the rat nucleus accumbens but not in the striatum.
Morphine-induced increase of dopamine metabolism in the striatum and nucleus accumbens was studied in rats treated with parachlorophenylalanine, an inhibitor of serotonin synthesis, or metergoline and mianserin, two serotonin antagonists. Morphine's effect in the nucleus accumbens, but not in the striatum, was significantly reduced by all the agents used to reduce serotonin transmission. It thus appears that part of the effect of morphine on dopamine metabolism in the nucleus accumbens is mediated by its ability to activate 5-HT function in this area.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D010134:Fenclonine / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D008803:Mianserin / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D012686:Septal Nuclei / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D012702:Serotonin Antagonists; D008711:Metergoline; D008803:Mianserin; D012701:Serotonin; D009020:Morphine; D010134:Fenclonine; D004298:Dopamine; D006719:Homovanillic Acid