title: Ehrlich ascites cells activate the alternative pathway of the human complement system.
abstract: Incubation of Ehrlich ascites cells with normal or C1q or C2 deficient human sera results in killing of the cells. Killing occurred also in the absence of free Ca++, which supported by the fact that factor B and C3 were cleaved, leads to the conclusion that the alternative pathway of the complement system is activated on the surface of the Ehrlich ascites cells.
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D003602:Cytotoxicity, Immunologic; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D011951:Receptors, Complement; D017463:Receptors, Complement 3b
chemical_list: D011951:Receptors, Complement; D017463:Receptors, Complement 3b