An immunofluorescent study of the ampicillin rash.
The aetiology of the ampicillin rash is uncertain although numerous theories have been proposed--mainly immunological. One such concerns the presence of anti-epithelial antibodies which have received conflicting reports in the literature. In this study, skin biopsies from three patients with a maculopapular ampicillin-rash were studied by immunofluorescence to investigate the presence of anti-epithelial antibodies. However immunofluorescence for IgG, IgM, IgA and C3 was completely negative so that we were unable to provide any support for this particular hypothesis.
D000667:Ampicillin / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D004487:Edema / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D004817:Epidermis / Q000187:drug effects / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006644:Histiocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology
D000667:Ampicillin