The effect of oligopeptides on the C3b receptor-mediated functions of rat macrophages.
Effects of various substances known to influence macrophage functions on the adherence of C3b-coated sheep erythrocytes (E-C3b) and their phagocytosis by elicited rat peritoneal macrophages (PM) has been studied. Different oligopeptides (OP) having a chemotactic effect, such as tuftsin, angiotensin II (At II) and the OP-fraction of a lymphokine preparation (LK-OP) increased both adherence and phagocytosis of E-C3b in a concentration-dependent fashion. In contrast, neither substances influencing the membrane cation transport nor prostaglandins (PG) and cyclic nucleotides significantly changed the C3b receptor (C3bR)-dependent effector functions of macrophages. Enhanced functions of the C3bR were not associated with an increased capability of PMs for intracellular killing of Candida albicans.
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D003179:Complement C3b / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic; D008222:Lymphokines / Q000502:physiology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D009842:Oligopeptides / Q000502:physiology*; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D011951:Receptors, Complement / Q000502:physiology; D017463:Receptors, Complement 3b; D012397:Rosette Formation; D014405:Tuftsin / Q000502:physiology
D008222:Lymphokines; D009842:Oligopeptides; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D000804:Angiotensin II; D003179:Complement C3b; D014405:Tuftsin