title: Somatomedin A in male puberty. Variation with age, maturity, growth and androgens.
abstract: Bioassayable somatomedin-A (SM-A) and serum concentrations of testosterone (T) and dehydroepiandrosterone (DHEA) were determined longitudinally in 26 normal boys during puberty. The mean trend of SM-A increased in relation to age, pubic hair development and peak height velocity (PHV) and significant correlations were observed with testicular volume, height velocity and T (all P less than 0.001) but not with DHEA. In relation to growth SM-A increased mainly during 12 to 6 months prior to PHV but no further increase was seen in the 6 months thereafter. Thus pubertal growth and development have to be taken into account in the evaluation of changes in bioassayable SM-A concentrations in boys.
mesh_terms: D000367:Age Factors; D000728:Androgens / Q000097:blood*; D001827:Body Height; D002648:Child; D003687:Dehydroepiandrosterone / Q000097:blood; D006801:Humans; D007335:Insulin-Like Growth Factor II; D008297:Male; D011627:Puberty; D012741:Sexual Maturation; D013002:Somatomedins / Q000097:blood*; D013739:Testosterone / Q000097:blood
chemical_list: D000728:Androgens; D013002:Somatomedins; D013739:Testosterone; D003687:Dehydroepiandrosterone; D007335:Insulin-Like Growth Factor II