title: Experimentally induced porcine proliferative enteritis in specific-pathogen-free pigs.
abstract: Thirty-three, 10-week-old, specific-pathogen-free pigs were randomly allotted to 3 treatment groups: group 1--intragastrically given homogenized intestinal mucosa (crude inoculum) from pigs with naturally occurring proliferative enteritis; group 2--given cultures of Campylobacter sputorum subsp mucosalis; and group 3--controls. One pig from each group was killed 4, 7, 10, 14, 18, 21, 24, 28, 31, 36, and 38 days after inoculation. The earliest intestinal lesion observed in groups 1 and 2 was leukocytic exudate within crypt lumina and focal inflammation of the surrounding lamina propria. The lesions occurred primarily over ileal aggregated lymphoid nodules (Peyer's patches). These changes were followed by focal proliferation of immature crypt epithelial cells and infiltration of increasing numbers of macrophages into the lamina propria. Campylobacter sp-like organisms were observed within the cytoplasm of affected epithelial cells by light and electron microscopies. Lesions progressed to diffuse crypt cell proliferation, elongation of crypts, and loss of villi. Mucosal necrosis was not a prominent feature.
mesh_terms: D000818:Animals; D002169:Campylobacter Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D002168:Campylobacter fetus / Q000302:isolation & purification / Q000472:pathogenicity; D002455:Cell Division; D004751:Enteritis / Q000473:pathology / Q000662:veterinary*; D004848:Epithelium / Q000473:pathology; D007082:Ileum / Q000382:microbiology / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008088:Listeriosis / Q000276:immunology / Q000662:veterinary; D051379:Mice; D009068:Movement; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000473:pathology*; D014774:Virulence