[Changes in the dopamine content in the brain of Periplaneta americana L. after application of structural analogs of dopamine and reserpine].
Changes in the content of dopamine (DA) in the CNS of the Cockroach (Periplaneta americana L.) after application of L-DOPA, p-chlorophenylalanine (p-CPA), alpha-methyltyrosine (MT), 6-hydroxydopamine (6-OHDA) and reserpine have been investigated by fluorimetric measures. The content of DA is increased by p-CPA, and decreased by MT and 6-OHDA. Reserpine exhibits a decreasing effect in high concentration only (30 micrograms/g body weight). Probably, the high compatibility of reserpine is caused by a special alkaloidesterase (a hypothetical "reserpinase").
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003058:Cockroaches / Q000378:metabolism*; D004298:Dopamine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007700:Kinetics; D007980:Levodopa / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D016627:Oxidopamine; D012110:Reserpine / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D019805:alpha-Methyltyrosine
D006892:Hydroxydopamines; D008781:Methyltyrosines; D007980:Levodopa; D019805:alpha-Methyltyrosine; D012110:Reserpine; D016627:Oxidopamine; D010134:Fenclonine; D004298:Dopamine
Zur Veränderung des Dopamin-Gehalts im Gehirn von Periplaneta americana L. nach Applikation von Strukturanaloga des Dopamins sowie von Reserpin.