L-3-123I-alpha-methyltyrosine for melanoma detection: a comparative evaluation.
L-3-123I-alpha-methyltyrosine (IMT) was compared to [67Ga]citrate, [203Pb]Tris and [131I]iodochloroquine (ICQ) with respect to their potential as melanoma seeking radiopharmaceuticals in two tumor lines, a malignant melanotic melanoma of the Sofia type and a malignant amelanotic melanoma of the Greene-Harvey type, transplanted onto Syrian Golden hamsters. [203Pb]Tris and ICQ showed significant accumulation only in melanotic melanoma. In contrast, [67Ga]citrate and IMT accumulated in both tumor lines. [67Ga]citrate has very high tumor-to-skin, tumor-to-eye, and tumor-to-blood ratios at 48 h after injection, but has low selectivity for melanoma and unfavorable physical (high gamma-energy) and biological (half-time) characteristics. IMT has a convenient gamma-energy at 159 keV and a short biological half-time. Maximum of melanoma accumulation is reached at 1-2h after application; tumor-to-tissue ratios are suitable for scintigraphy.
D000818:Animals; D002460:Cell Line; D007464:Clioquinol / Q000378:metabolism; D006224:Cricetinae; D005710:Gallium Radioisotopes / Q000378:metabolism; D007457:Iodine Radioisotopes; D007854:Lead; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D008647:Mesocricetus; D008781:Methyltyrosines / Q000378:metabolism*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012878:Skin Neoplasms / Q000378:metabolism; D014018:Tissue Distribution; D014325:Tromethamine / Q000378:metabolism
D005710:Gallium Radioisotopes; D007457:Iodine Radioisotopes; D008781:Methyltyrosines; D011868:Radioisotopes; D014325:Tromethamine; D007854:Lead; D007464:Clioquinol; C030855:3-iodo-alpha-methyltyrosine