Hydroxamate siderophore mediated iron uptake in E. coli: stereospecific recognition of ferric rhodotorulic acid.
Ferric ion uptake via the fhuE receptor of E. coli is stereospecific; it prefers the delta-absolute configuration of the metal complexes. The importance of the metal center and its adjacent functionalities for the stereospecific recognition of ferrichromes via TonA is discussed.
D001692:Biological Transport / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D006877:Hydroxamic Acids / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000494:pharmacology*; D007700:Kinetics; D008968:Molecular Conformation; D010879:Piperazines / Q000494:pharmacology; D017262:Siderophores; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D006877:Hydroxamic Acids; D007502:Iron Chelating Agents; D010879:Piperazines; D017262:Siderophores; C003305:rhodotorulic acid; D007501:Iron