Preparation of HSA microspheres in a one-step thermal denaturation of protein aerosol carried in gas-medium.
A simple, one-step method of preparation of human albumin microspheres by thermal denaturation of protein aerosol in a gas medium is described. These microspheres were easily labelled with technetium-99m and iodine-131, and were characterized by short biological clearance and high lung uptake.
D000818:Animals; D006207:Half-Life; D006358:Hot Temperature; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008722:Methods; D051379:Mice; D008863:Microspheres; D011489:Protein Denaturation; D012709:Serum Albumin / Q000302:isolation & purification / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013667:Technetium / Q000378:metabolism; D013668:Technetium Tc 99m Aggregated Albumin
D007457:Iodine Radioisotopes; D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; D013667:Technetium