Effects of isotretinoin on the neutrophil chemotaxis in cystic acne.
The authors show that the use of Isotretinoin (Ro 4-3740) in cystic acne brings a reduction of chemotactic activity of the neutrophil granulocytes, like another retinoid, Etretinate, in pustular and vulgar psoriasis. This effect of retinoids, with a direct action on the polymorphonuclear leukocytes plays an important role in the recovery of the disease.
D000152:Acne Vulgaris / Q000097:blood*; D000293:Adolescent; D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D015474:Isotretinoin; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin; D015474:Isotretinoin