Pilot study for large-scale plasma procurement using automated plasmapheresis.
A pilot study for large-scale automated plasmapheresis using the Haemonetics Model 50 machine was undertaken in the Yorkshire Region of the United Kingdom to determine the viability of such a programme for national self-sufficiency in fresh plasma procurement for factor VIII concentrate production. The study was designed to resolve three areas of concern: donor safety and recruitment; a cost analysis, and the choice of anticoagulant for optimum factor VIII yields. The results show that large-scale automated plasmapheresis could safely and economically produce high-quality source plasma necessary for national self-sufficiency.
D000925:Anticoagulants / Q000494:pharmacology; D001772:Blood Cell Count; D001782:Blood Donors / Q000523:psychology; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D003362:Cost-Benefit Analysis; D004912:Erythrocytes / Q000166:cytology; D005169:Factor VIII / Q000032:analysis; D009042:Motivation; D010949:Plasma; D010956:Plasmapheresis / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D010976:Platelet Count; D001620:beta-Thromboglobulin / Q000032:analysis
D000925:Anticoagulants; D001620:beta-Thromboglobulin; D005169:Factor VIII