Effect of short-term bile duct ligation on peripheral blood steroids, urinary PGE2 and the rate of sodium excretion in male rabbits.
Short-term bile duct ligation in male rabbits resulted in a significant reduction in the rate of sodium excretion after saline challenge (10 ml/kg/hr for 4 hr, P less than 0.03). The reduction in the sodium excretory rate (14.3 +/- 7.8 to 6.3 +/- 5 mu-equiv/min, P less than 0.03) was associated with an increased urinary PGE2 excretion (200.9 +/- 174 to 731.8 +/- 1039.8 pg/min, P less than 0.01) without significant change in serum aldosterone and cortisol concentrations. Serum progesterone concentration increased (37.2 +/- 15.6 to 119.2 +/- 34.6 ng/dl, P less than 0.01) whereas serum 17-hydroxyprogesterone concentration declined after bile duct ligation suggesting the development of a 17-hydroxylase enzymatic block.
D019326:17-alpha-Hydroxyprogesterone; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003135:Common Bile Duct / Q000502:physiology*; D003687:Dehydroepiandrosterone / Q000097:blood; D015232:Dinoprostone; D006854:Hydrocortisone / Q000097:blood; D006908:Hydroxyprogesterones / Q000097:blood; D007700:Kinetics; D008026:Ligation; D008297:Male; D009318:Natriuresis; D011374:Progesterone / Q000097:blood; D011458:Prostaglandins E / Q000652:urine*; D011817:Rabbits; D013256:Steroids / Q000097:blood*; D013997:Time Factors
D006908:Hydroxyprogesterones; D011458:Prostaglandins E; D013256:Steroids; D003687:Dehydroepiandrosterone; D000450:Aldosterone; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone; D015232:Dinoprostone; D006854:Hydrocortisone