Differential activity of enantiomers of amphetamine in rats.
Administration of single doses of d-amphetamine (0.5-4.0 mg/kg i.p.) to adult, male rats produced the expected dose-related increases in spontaneous motor activity. This effect was reduced by pretreatment with alpha-methylparatyrosine (alpha MT) and virtually unaffected by pretreatment with pargyline or parachlorophenylalanine (PCPA). Single doses of l-amphetamine (0.25-8.0 mg/kg) evoked an initial decrease in activity followed by increased activity of smaller magnitude than that caused by the d-isomer. The depressant effects of the l-isomer were prolonged by pretreatment with alpha MT, and abolished by pretreatment with pargyline or PCPA.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002395:Catecholamines / Q000502:physiology; D003913:Dextroamphetamine / Q000494:pharmacology*; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology; D013237:Stereoisomerism; D013997:Time Factors; D019805:alpha-Methyltyrosine
D002395:Catecholamines; D008781:Methyltyrosines; D012701:Serotonin; D019805:alpha-Methyltyrosine; D010293:Pargyline; D000661:Amphetamine; D010134:Fenclonine; D003913:Dextroamphetamine