[Mechanisms of azlocillin resistance in Pseudomonas aeruginosa].
The authors have evaluated the susceptibility of azlocillin to beta-lactamases habitually produced by Pseudomonas aeruginosa, i.e. TEM and CARB types penicillinases and the so-called Sabath and Abraham cephalosporinase. As all penicillins, azlocillin is liable to hydrolysis by penicillinases that also affect, through to a lesser extent, some cephalosporin. It is also degraded, albeit moderately by the Sabath and Abraham cephalosporinase. The authors have also compared the behaviour of azlocillin towards beta-lactamases to that of other beta-lactam antibiotics, notably carbenicillin, cefoperazone and cefsulodin.
D001390:Azlocillin; D002228:Carbenicillin / Q000494:pharmacology; D002510:Cephalosporinase / Q000378:metabolism; D006868:Hydrolysis; D010403:Penicillin Resistance; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000378:metabolism*
D010406:Penicillins; D002510:Cephalosporinase; D010405:Penicillinase; D001618:beta-Lactamases; D002228:Carbenicillin; D001390:Azlocillin
Mécanismes de résistance à l'azlocilline chez Pseudomonas aeruginosa.