Immunofluorescence studies on the codistribution immune deposits and complement in the thyroid glands of Obese strain (OS) chickens.
This study demonstrates immune complexes in thyroid glands of Obese strain (OS) chickens, that consist of thyroglobulin (Tg) and antibodies to Tg. In IIF tests it was shown that these complexes fix complement with an age-dependent increase from 12% in 19-day-old embryos up to 100% in 6-week-old animals. This finding and the observation that the deposition of complement-binding immune complexes precede cellular infiltration of the thyroid gland and correlate with the serum titer of Tg-Ab (as one parameter of the disease) points towards a role as one initial effector mechanism for the development of spontaneous autoimmune thyroiditis (SAT).
D000818:Animals; D002645:Chickens; D003168:Complement Fixation Tests; D003165:Complement System Proteins / Q000032:analysis* / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D007105:Immune Complex Diseases / Q000150:complications / Q000276:immunology*; D008431:Maternal-Fetal Exchange; D009765:Obesity / Q000150:complications / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*; D013966:Thyroiditis / Q000276:immunology
D003165:Complement System Proteins; D013954:Thyroglobulin