[Articular chondrocalcinosis. Association with B15 antigen].
Antigens of HLA loci A, B and DR were determined in 35 elderly patients with primary articular chondrocalcinosis and compared with a control population. The B15 antigen was present in 13 out of 35 patients, i.e. 37.1% as against 13% of controls (chi 2 = 13.4; pc = 0.05) and the BW21 antigen in 8 out of 35 patients, i.e. 22.8% as against 6.6% of controls (chi 2 = 10.25; pc less than 0.005). These results confirm those of a previous study carried out in the same unit, which showed a 41% incidence of HLA B15 antigen in patients with chondrocalcinosis. The HLA B15 antigen seems to be a marker of imbalanced binding with a susceptibility antigen. Calculation of the relative risk shows that an elderly subject with HLA B15 antigen if about 4 times more liable to articular chondrocalcinosis than a subject without this antigen.
D000368:Aged; D002805:Chondrocalcinosis / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D006801:Humans
D006680:HLA Antigens; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen
Chondrocalcinose articulaire. Association avec l'antigène B15.