[Studies on the combination action of sisomicin, gentamicin and piperacillin, cefmetazole against Pseudomonas aeruginosa and Serratia marcescens].
The combined actions of sisomicin (SISO), gentamicin (GM) and piperacillin (PIPC), cefmetazole (CMZ) against Pseudomonas aeruginosa E-2 and Serratia marcescens T-55 were studied. The following results were obtained. 1. The combinations of SISO-PIPC, SISO-CMZ, GM-PIPC and GM-CMZ using the checker board dilution method on P. aeruginosa E-2 and S. marcescens T-55 were found to have a synergistic effect and the minimum FIC index values were 0.38 in all combinations. 2. With the killing kinetic method, all combinations tested showed a synergistic effect. 3. A synergistic effect of the combinations of SISO-PIPC, SISO-CMZ, GM-PIPC and GM-CMZ was observed in the protective effect on experimental P. aeruginosa E-2 and S. marcescens T-55 infections in mice.
D000818:Animals; D015311:Cefmetazole; D002511:Cephalosporins / Q000008:administration & dosage*; D002513:Cephamycins / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005839:Gentamicins / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D010403:Penicillin Resistance; D010406:Penicillins / Q000008:administration & dosage*; D010878:Piperacillin; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development; D012706:Serratia marcescens / Q000187:drug effects* / Q000254:growth & development; D012853:Sisomicin / Q000008:administration & dosage*
D002511:Cephalosporins; D002513:Cephamycins; D005839:Gentamicins; D010406:Penicillins; D015311:Cefmetazole; D010878:Piperacillin; D012853:Sisomicin