[Topical antimicrobial therapy: the efficacy of clioquinol- and tribromphenolbismuth- zinc oxide preparations].
Clioquinol- and tribromphenolwismut zinc oxide preparations were tested in vitro in order to investigate their bactericidal and bacteriostatic efficacy against strains of staphylococcus aureus, E. coli, pseudomonas as well as against the fungi candida albicans and trichophyton rubrum. The results show that there was both a bacteriostatic and a bacteriocidal effect of clioquinol except against pseudomonas. Tribromphenolwismut has less efficacy. In spite of some suggestions in the literature our results confirm that the efficacy of clioquinol is not impaired if combined with zinc oxide. The use of this well tolerated preparation is recommended in the treatment of infectious dermatoses even today.
D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects; D007464:Clioquinol / Q000627:therapeutic use*; D006801:Humans; D006912:Hydroxyquinolines / Q000627:therapeutic use*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D010636:Phenols / Q000627:therapeutic use*; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D012882:Skin Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D015034:Zinc Oxide / Q000627:therapeutic use
D000891:Anti-Infective Agents, Local; D006912:Hydroxyquinolines; D010636:Phenols; D007464:Clioquinol; D015034:Zinc Oxide; C004554:2,4,6-tribromophenol
Antimikrobielle Lokaltherapie: Zur Wirksamkeit von Clioquinol- und Tribromphenolwismut-Zinkoxid-Zubereitungen.