title: Skin protection against ionized cobalt and sodium lauryl sulphate with barrier creams.
abstract: 853 individuals who are still working or had previously worked in hard metal manufacture were examined and selected for patch tests with materials from their working environment including metal allergens. The majority of the individuals with positive test reactions to cobalt chloride were retested with serial dilutions of cobalt chloride and with the same serial dilutions after preparation of the skin with a layer of barrier or emollient cream used for hand care in this factory. The irritant effect of sodium lauryl sulphate (SLS) was similarly investigated. The barrier and emollient creams did not give any protection against cobalt chloride or sodium lauryl sulphate. In fact they seemed to enhance the penetration of cobalt ions. Their use in protection against metal allergens and cutting fluids is questionable.
mesh_terms: D003035:Cobalt / Q000633:toxicity*; D009783:Dermatitis, Occupational / Q000517:prevention & control*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D006801:Humans; D007509:Irritants; D009824:Ointments; D012967:Sodium Dodecyl Sulfate / Q000633:toxicity*
chemical_list: D003879:Dermatologic Agents; D007509:Irritants; D009824:Ointments; D012967:Sodium Dodecyl Sulfate; D003035:Cobalt