Mouse plasma trypsin inhibitors: inhibitory spectrum of contrapsin and alpha-1-antitrypsin.
We have studied the effects of murine alpha-1-antitrypsin and contrapsin, a new trypsin inhibitor (Takahara, H. and Sinohara, H. (1982) J. Biol. Chem. 257, in press), on several serine proteases participating in blood clotting, fibrinolysis, kinin generation, and complement activation. Bovine plasmin and human plasma kallikrein were inactivated by contrapsin but not by alpha-1-antitrypsin, whereas bovine alpha-thrombin and porcine pancreas kallikrein were inhibited by alpha-1-antitrypsin but not by contrapsin. Heparin protected thrombin from inactivation by alpha-1-antitrypsin. Both inhibitors had virtually no effects on canine C1 esterase.
D000818:Animals; D000990:Antithrombin III / Q000494:pharmacology; D002417:Cattle; D003174:Complement C1 Inactivator Proteins / Q000378:metabolism; D004285:Dogs; D005341:Fibrinolysin / Q000037:antagonists & inhibitors; D006801:Humans; D007610:Kallikreins / Q000037:antagonists & inhibitors; D051379:Mice; D015843:Serpins; D013552:Swine; D013917:Thrombin / Q000037:antagonists & inhibitors; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D000515:alpha 1-Antitrypsin / Q000494:pharmacology*; D000979:alpha-2-Antiplasmin / Q000494:pharmacology
D003174:Complement C1 Inactivator Proteins; D015843:Serpins; D014361:Trypsin Inhibitors; D000515:alpha 1-Antitrypsin; D000979:alpha-2-Antiplasmin; C033691:contrapsin; D000990:Antithrombin III; D007610:Kallikreins; D013917:Thrombin; D005341:Fibrinolysin