title: Dose-response relationship in isotretinoin therapy for conglobate acne.
abstract: 58 male patients with therapy-resistant conglobate acne were randomly selected for treatment with isotretinoin 1.0 or 0.5 mg/kg bodyweight. 27 patients received the high-dose regimen and 31 patients the lower dosage. The efficacy of the drug was highly satisfactory in both therapy groups and no differences could be observed between them. Side-effects (dry lips, dry nose, scaling of the skin) were generally well tolerated in both groups, they were more serious in the 1.0-mg/kg group. It is concluded that isotretinoin therapy is very effective in male patients with conglobate acne and that a dosage of 0.5 mg/kg is preferable to higher dosage regimens.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015474:Isotretinoin; D008297:Male; D011897:Random Allocation; D012621:Seasons; D014212:Tretinoin / Q000008:administration & dosage* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D014212:Tretinoin; D015474:Isotretinoin