Decreased fertility, increased dominant lethals, skeletal malformations induced in the mouse by Ziram fungicide.
The toxic effect of the Ziram fungicide (Zn-dimethyldithiocarbamate) on fertility, its lethal and teratogenic potential were tested on two mouse strains, C3H and AK. The fungicide was administered by gavage to male mice in daily doses of 0.2 mg% and 0.1 mg% along three weeks, then the mice were mated with normal females. Ziram induced changes in the testes and meiotic chromosomes. From among the mated females, 80 per cent of the C3H mice and 20 per cent of the AK remained unfertilized. The dominant lethals have a higher incidence in the AK strain. The skeletal malformation induced were kyphosis, scoliosis, sternum ossification failure; retardation in skeletal development is more obvious in the AK strain.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities*; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D011247:Pregnancy; D013737:Testis / Q000187:drug effects; D013859:Thiocarbamates / Q000633:toxicity*; D015039:Ziram / Q000633:toxicity*
D013859:Thiocarbamates; D015039:Ziram