Nonsteroid antiinflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach.
The results of treatment of desmoid tumor patients with nonsteroid antiinflammatory drugs alone or in combination with tamoxifen are described. Tumor growth was inhibited in six of seven patients. Nonsteroid antiinflammatory drugs administered along with 5-fluorouracil and cyclophosphamide and other inhibitors of T-suppressor cells were used to treat nine patients with metastatic carcinoma of the stomach. Survival of these patients was extended so that after 12 months minimal follow-up the majority are well. A prospective controlled clinical trial is indicated.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005350:Fibroma / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage; D005736:Gardner Syndrome / Q000150:complications; D005743:Gastrectomy; D006801:Humans; D007275:Injections, Intravenous; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D013629:Tamoxifen / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D013629:Tamoxifen; D003520:Cyclophosphamide; D005472:Fluorouracil