[Effect of medroxyprogesterone acetate (MAP) and vitamin C on DMBA induced rat mammary cancer in relation to estrogen receptor(ER)].
In mature male and female SD rats, the anti-weight gain effect of durabolin plus vitamin C or vitamin C alone was statistically significant compared to durabolin-treated and control rats. The anti-tumor and anti-weight gain effects of MAP plus vitamin C on DMBA-induced rat mammary cancer were compared with those of MAP and vitamin C in relation to ER. An anti-tumor effect was noted in the MAP treated groups, irrespective of the ER status; it was more pronounced in the MAP (100 mg/kg) plus vitamin C treated group with ER+tumors. Among the ER+tumor groups, weight gain was remarkable in the MAP-treated (20 mg/kg) animals; an anti-weight gain effect was seen in the MAP (20 mg/kg) plus vitamin C group.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage*; D005260:Female; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000032:analysis / Q000139:chemically induced / Q000188:drug therapy*; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017258:Medroxyprogesterone Acetate; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000032:analysis*
D011960:Receptors, Estrogen; D015127:9,10-Dimethyl-1,2-benzanthracene; D009277:Nandrolone; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; C008580:nandrolone phenpropionate; D001205:Ascorbic Acid