A comparison of Fc-receptor-bearing lymphocytes in normal individuals and in patients with lymphoproliferative diseases, using EA tests with rabbit and human-sensitizing antibodies.
A comparison between the percentage of rosettes in EA tests, using rabbit and human-sensitizing antibodies and the depletion experiments of rosette-forming lymphocytes, showed that both systems can be used equally well to detect Fc-receptors on mature peripheral blood lymphocytes. The observations made in B-chronic lymphocytic leukaemia and immunocytoma patients suggested, however, that both EA tests determine lymphocytes that differ in Fc-receptors from normal lymphocytes. The possibility that the differences in Fc-receptors are connected with the stage of maturation of lymphocytes is discussed.
D000818:Animals; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D011817:Rabbits; D011961:Receptors, Fc / Q000032:analysis*; D017452:Receptors, IgG; D012397:Rosette Formation; D012756:Sheep
D011961:Receptors, Fc; D017452:Receptors, IgG