title: Immune responses of swine to oral inoculation with embryonated eggs of Ascaris suum.
abstract: Responses of swine to oral inoculation with embryonated eggs of Ascaris suum were monitored, using lymphocyte blastogenesis assays, indirect radioimmunoassays, and peripheral eosinophil counts (EC). Transient cell-mediated immune responses of peripheral lymphocytes were detected by lymphocyte blastogenesis assay as early as postinoculation day (PID) 2, but were rarely positive for consecutive samples taken at 2-day intervals. Humoral antibodies were first detected at PID 6 to 17 by indirect radioimmunoassays in the various experiments. Positive cutaneous delayed hypersensitivity reactions were observed when pigs were tested at 6 to 7 weeks after inoculation. Histopathologic examination verified infiltration of lymphocytes into the lesions. The EC increased as early as PID 4 to 7 and showed a secondary increase after the 2nd oral inoculation of eggs to as high as 11,400/mm3 (44% of the total WBC). Subsequently, EC decreased rapidly 14 days after the last inoculation of eggs.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D001200:Ascaris / Q000196:embryology / Q000276:immunology*; D004804:Eosinophils; D005260:Female; D006168:Guinea Pigs / Q000276:immunology; D007111:Immunity, Cellular; D007958:Leukocyte Count / Q000662:veterinary; D010063:Ovum / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D013552:Swine / Q000276:immunology*
chemical_list: D000906:Antibodies