Allergic contact dermatitis due to urethane acrylate in ultraviolet cured inks.
Seven workers exposed to ultraviolet printing inks developed contact dermatitis. Six cases were allergic and one irritant. A urethane acrylate resin accounted for five cases of sensitisation, one of which was also sensitive to pentaerythritol triacrylate and another also to an epoxy acrylate resin. One instance of allergy to trimethylpropane triacrylate accounted for the sixth case of contact dermatitis in this group of workers. An irritant reaction is presumed to account for the dermatitis in the individual not proved to have cutaneous allergy by patch tests. In this instance trimethylpropane triacrylate was thought to be the most likely irritating agent. Laboratory investigation proved urethane acrylate to be an allergen. The results of investigations of the sensitisation potentials of urethane acrylate, methylmethacrylate, epoxy acrylate resins, toluene-2,4-diisocyanate, and other multifunctional acrylic monomers in the albino guinea pig are presented. The interpretation of such predictive tests is discussed.
D000179:Acrylates / Q000009:adverse effects; D000180:Acrylic Resins / Q000009:adverse effects*; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D004853:Epoxy Resins / Q000009:adverse effects; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007281:Ink; D008297:Male; D011140:Polyurethanes / Q000009:adverse effects*; D011327:Printing; D011409:Propylene Glycols; D011817:Rabbits; D012867:Skin / Q000473:pathology
D000179:Acrylates; D000180:Acrylic Resins; D004853:Epoxy Resins; D011140:Polyurethanes; D011409:Propylene Glycols; C027993:trimethylolpropane triacrylate; C020355:1,6-hexanediol diacrylate; C027992:pentaerythrityl triacrylate