Deficiency of Con A-induced suppressor cell activity in peripheral blood mononuclear cells from Thai adults naturally infected with Plasmodium falciparum and Plasmodium vivax.
Con A-pretreated mononuclear (MNC) cells from Thai adults with naturally acquired P. falciparum or P. vivax malaria were significantly less effective in suppressing the responsiveness of autologous or normal allogeneic responder cells to mitogenic lectins or allogenic stimulator cells than pretreated cells from healthy donors. Serial studies of three patients demonstrated that reduced suppressor cell activity was present early in malaria infection but returned to normal soon after treatment. These studies demonstrate that the loss of T cells previously observed in patients with malaria, in part may functionally represent a loss of suppressor T cells.
D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008288:Malaria / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D010963:Plasmodium falciparum; D010966:Plasmodium vivax; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013785:Thailand
D010835:Phytohemagglutinins; D003208:Concanavalin A