title: Comparison of acetylcholine sensitivity in asthmatics with negative and positive response to exercise.
abstract: Airways response to inhaled acetylcholine was studied in asthmatic patients with negative and positive response to exercise. The respiratory threshold of acetylcholine proved to be lower in exercise-responders. Mean value of the bronchoconstrictive dose of acetylcholine was found 72 +/- 78 micrograms in patients with positive, while 510 +/- 360 micrograms in those with negative response to exercise challenge. Our data seem to confirm previous hypotheses, i.e. that exercise-induced asthma is a phenomenon dependent on two factors: mediators generated during exercise (histamine, catecholamines, neutrophil chemotactic factor) and a vagal response from the bronchi.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D005082:Physical Exertion; D012119:Respiration / Q000187:drug effects; D013147:Spirometry
chemical_list: D000109:Acetylcholine