[Insulin reserve of insulin-dependent diabetics. Role of C-peptide in the hormonal balance in diabetes].
Insulin secretion was investigated in 65 insulin-dependent diabetic patients by determining C peptide levels before and after stimulation with either an 800 calories test meal or an injection of glucagon or arginine i.v. Most patients had very low basal C peptide levels and response to all stimulation tests was poor as compared to controls. In normal subjects, response to glucagon or arginine stimulation appeared to be slightly stronger than response to test meal stimulation. There was apparently no correlation between diabetes control, as assessed by haemoglobin A1c values, and C peptide levels before and after stimulation. On the other hand, C peptide levels were inversely proportional to the duration of diabetes. Finally, C peptide levels after test meal stimulation were found to correlate with  the doses of insulin administered.
D000328:Adult; D001835:Body Weight; D002096:C-Peptide / Q000097:blood / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000502:physiology*; D013997:Time Factors
D002096:C-Peptide; D007328:Insulin; D010455:Peptides
La réserve insulinique du diabétique insulino-dépendant. Rôle du peptide C dans l'équilibre du diabète.