[Immunodepressive action and effects of medroxyprogesterone acetate on the lymphatic tissue of the rabbit appendix].
The influence of medroxyprogesterone acetate (MPA) on lymphoid tissue of rabbit appendix was investigated. The agent caused a uniform depletion of lymphoid cells, which confirmed the immunodepressive properties of the drug. Other findings suggested a corticoid action of the agent and a possible anticellular activity, interfering with nucleic acid synthesis of proliferating cells.
D000818:Animals; D001065:Appendix / Q000187:drug effects* / Q000276:immunology; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000276:immunology; D017258:Medroxyprogesterone Acetate; D011817:Rabbits; D013997:Time Factors
D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone
Azione immunodepressiva ed effetti del medrossiprogesterone acetato sul tessuto linfatico dell'appendice di coniglio.