[Activity of dopaminergic neurons of the substantia nigra following lesions of the neostriatum by kainic acid].
Neostriatal lesions by kainic acid provide a good model for studying Huntington's chorea. The pattern of discharge of nigral dopaminergic neurons of rats subjected to a kainate lesions of the caudate nucleus was compared to the nigral activity in control (saline-injected) and normal rats. The observed changes suggest that neostriatal degeneration does not simply induce a nigral dopaminergic hyperactivity but rather a disorganization of their slow and rhythmic pattern of discharge, thus eliciting in the nigral neurons abnormal messages which may reach the motoneurons and participate in the genesis of choreic movements.
D000200:Action Potentials; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects*; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology*; D004594:Electrophysiology; D006816:Huntington Disease / Q000503:physiopathology; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000502:physiology*; D011699:Putamen / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000503:physiopathology*
D011759:Pyrrolidines; D007608:Kainic Acid; D004298:Dopamine
Activité des neurones dopaminergiques de la substance noire aprés dlésion du néostriatum par l'acide kaïnique.