title: Induction of the SOS system by DNA ligase-deficient growth of Escherichia coli.
abstract: When Escherichia coli carrying a thermosensitive mutation in DNA ligase was grown at the restrictive temperature, several functions associated with the SOS system were induced. These included lambda prophage induction, W-reactivation and W-mutagenesis of ultraviolet-irradiated lambda phage, and recA protein synthesis, all of which were lexA+ recA+ recB+ dependent and chloramphenicol sensitive, and lexA+-dependent filamentation. These results indicate that ligase-deficient growth leads to the induction of the SOS system, and that all the above functions may respond to common induction signals.
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis; D010582:Bacteriophage lambda / Q000235:genetics / Q000254:growth & development; D002455:Cell Division; D011088:DNA Ligases / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D011118:Polynucleotide Ligases / Q000378:metabolism*; D011938:Rec A Recombinases; D011995:Recombination, Genetic; D014775:Virus Activation
chemical_list: D001426:Bacterial Proteins; D011938:Rec A Recombinases; D011088:DNA Ligases; D011118:Polynucleotide Ligases