[Lethal and mutagenic activity of tritiated water and incorporated [3H-methyl]-thymidine on extracellular phage lambda].
A study was made of lethal and mutagenic effects on extracellular phage lambda of beta-particles from tritiated water and of [3H-methyl]-thymidine incorporated into DNA. It was shown that the mean lethal dose D10 and the yield of c-mutations per unit of the dose absorbed during external beta-irradiation in 3H2O or during the decay of incorporated [3H-methyl]-thymidine were equivalent to those obtained during 60Co-gamma-irradiation in 4% nutrient broth or at a dried state respectively.
D010582:Bacteriophage lambda / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D003090:Coliphages / Q000528:radiation effects; D004279:DNA, Viral / Q000528:radiation effects; D005720:Gamma Rays; D009152:Mutagenicity Tests; D009153:Mutagens; D011829:Radiation Dosage; D013936:Thymidine / Q000031:analogs & derivatives; D014316:Tritium / Q000633:toxicity*; D014867:Water; D014869:Water Intoxication
D003037:Cobalt Radioisotopes; D004279:DNA, Viral; D009153:Mutagens; D014867:Water; D014316:Tritium; C033961:tritium oxide; C012439:methylthymidine; D013936:Thymidine
Letal'noe i mutagennoe deĭstvie tritievoĭ vody i inkorporirovannogo [3H-metil]-timidina na vnekletochnyĭ fag liambda.