title: Excess granulation tissue responses associated with isotretinoin therapy.
abstract: Multiple polypoid projections of granulation tissue developed in two patients receiving isotretinoin for acne. Histological study of the lesions revealed increased amounts of non-sulphated acid mucopolysaccharides in the ground substance of the granulation tissue stroma. Complete resolution occurred following curettage with or without chemical cautery. The role of isotretinoin in the development of these lesions is discussed.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D006097:Granulation Tissue / Q000473:pathology*; D006801:Humans; D007536:Isomerism; D015474:Isotretinoin; D008297:Male; D012867:Skin / Q000473:pathology*; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014212:Tretinoin; D015474:Isotretinoin