title: Tolerance of tetrabenazine during long-term treatment.
abstract: Side-effects, haematological, hepatic and renal changes during long-term treatment with tetrabenazine (Nitoman) were assessed in a multicentre trial of 124 patients with various hyperkinetic syndromes. Side-effects were infrequent and usually mild. They necessitated discontinuation of therapy in 5 cases. Changes in clinico-chemical tests during 12 months on tetrabenazine were always minor, nearly always unsystematic and, on the whole, tended more towards a normalization of values than the opposite. Even recognizing the limitations inherent in a uncontrolled trial, we conclude that long-term treatment with tetrabenazine seems to be quite safe.
mesh_terms: D000368:Aged; D004361:Drug Tolerance; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D013747:Tetrabenazine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013747:Tetrabenazine