[Effect of vitamin A deficiency in mice on the formation of specific cytolytic T-lymphocytes].
Content of retinol, retinyl acetate and retinyl palmitate was studied by means of high pressure liquid chromatography, in liver tissue of mice, kept on a vitamin A-free diet during various periods of time. Cell proliferative activity and formation of specific T-killers were distinctly inhibited in mixed culture of lymphocytes from spleen tissue of A-avitaminous animals. Proliferative and cytolytic activity of the stimulated lymphocytes might be corrected by means of retinoic acid and retinyl acetate in vitro and in vivo.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes; D005260:Female; D007694:Killer Cells, Natural / Q000473:pathology; D008099:Liver / Q000032:analysis; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D012176:Retinoids / Q000032:analysis*; D000084562:Retinyl Esters; D013154:Spleen / Q000032:analysis; D013602:T-Lymphocytes, Cytotoxic / Q000473:pathology*; D014801:Vitamin A / Q000031:analogs & derivatives / Q000032:analysis; D014802:Vitamin A Deficiency / Q000276:immunology* / Q000378:metabolism
D004224:Diterpenes; D012176:Retinoids; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; C009166:retinol acetate
Vliianie nedostatka vitamina A u mysheĭ na obrazovanie spetsificheskikh tsitoliticheskikh T-limfotsitov.