Increased incidence of transient homogeneous immunoglobulins in irradiated and reconstituted C57BL/KaLwRij mice treated with 2'-deoxyguanosine.
Prolonged administration of micromolar amounts of 2'-deoxyguanosine (dGuo) to lethally irradiated and reconstituted mice led to an increased incidence of transient homogeneous immunoglobulins (H-Ig) in their sera. Analysis of the heavy and light chain isotype distribution among the H-Ig revealed more of the IgG2b and IgG3 isotypes and less of the IgM isotype and the lambda light chain containing H-Ig in the dGuo-treated group as compared to the control group. The increased incidence of H-Ig was preceded by a decreased suppressor T cell generation and activation in the dGuo treated group. These data indicate that deficient suppressor T cell activity plays an important role in the development of transient H-Ig.
D000818:Animals; D003849:Deoxyguanosine / Q000494:pharmacology*; D005260:Female; D006087:Graft vs Host Reaction; D006968:Hypersensitivity, Delayed; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D014916:Whole-Body Irradiation
D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007136:Immunoglobulins; D003849:Deoxyguanosine