Effects of antithyroid drugs on Con A-induced suppressor cell activity.
It is well established that Concanavalin A (Con A)-induced human peripheral blood lymphocytes exert suppressive effects on mitogen-induced proliferation of responder cells. Using peripheral blood lymphocytes from healthy individuals, effects of antithyroid drugs on Con A-induced suppressor function were studied. We found an enhancement of Con A-stimulated suppressor activity by MMI and PTU in all these subjects. In the light of these data, an enhancement in suppressor activity by antithyroid drugs may contribute, in part, to a remission of Graves' disease.
D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008713:Methimazole / Q000494:pharmacology*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D011441:Propylthiouracil / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*
D008937:Mitomycins; D003208:Concanavalin A; D016685:Mitomycin; D008713:Methimazole; D011441:Propylthiouracil