The effect of a high-fat diet on brainstem and duodenal serotonin (5-HT) metabolism in Sprague-Dawley and Osborne-Mendel rats.
Sprague-Dawley (S-D) and Osborne-Mendel (O-M) rats were fed either a low-fat diet (5 percent corn oil) or high-fat diet (20 percent corn oil) for a six-week-period. Brainstem and duodenal levels of tryptophan, serotonin (5-hydroxytryptamine, 5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) were not altered by dietary treatment in the O-M rats. On the other hand, the high-fat diet significantly decreased brainstem 5-HT levels in S-D rats. Brainstem and duodenal 5-HT levels were decreased in O-M rats as compared to S-D rats and this phenomenon is not altered by dietary treatment. It is suggested that the O-M rat may have a alteration in the 5-HT metabolic system and that such a defect may contribute to the development of obesity.
D000818:Animals; D001835:Body Weight; D001933:Brain Stem / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism
D004041:Dietary Fats; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan