Aspirin decreases platelet uptake on Dacron vascular grafts in baboons.
The influence of a single dose of aspirin (5.4-7.4 mg/kg) on platelet uptake on 4-mm Dacron interposition grafts was studied in a baboon model using gamma camera scanning for 111-Indium labeled platelets. In vitro assessment of platelet function after aspirin administration revealed that in the baboon, as in the human, aspirin abolished arachidonic acid-induced platelet aggregation, prolonged the lag time between exposure to collagen and aggregation, and decreased plasma thromboxane B2 levels. Aspirin also prolonged the template bleeding time. Scans for 111-Indium labeled platelets revealed that pretreatment with a single dose of aspirin decreased platelet uptake on 4-mm Dacron carotid interposition grafts. This decrease in platelet uptake was associated with a significant improvement in 2-hour graft patency and with a trend toward improved 2-week patency.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology*; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000601:surgery; D006085:Graft Survival; D007204:Indium; D008297:Male; D010215:Papio; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011093:Polyethylene Terephthalates; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013929:Thromboxane B2 / Q000097:blood; D013997:Time Factors
D001095:Arachidonic Acids; D011093:Polyethylene Terephthalates; D011868:Radioisotopes; D007204:Indium; D016718:Arachidonic Acid; D013929:Thromboxane B2; D001241:Aspirin