Genetic control of immune responses to Schistosoma japonicum antigen.
A high-titre IgE-antibody response to Schistosoma japonicum antigen (Sj) is obtained if helper T cells are appropriately induced by the infection. The antibody responses were found to be regulated by a gene(s) linked to the major histocompatibility complex. Strains of H-2a and H-2k haplotypes were high responders, whereas H-2d, H-2b and H-2s strains were not. Results obtained by using intra-H-2 recombinant strains suggested that the immune-response (Ir) gene was mapped in the I-E subregion, although a possibility of the presence of complementary genes was not excluded. Interestingly, in low responders such as BALB/c mice, Sj-specific carrier effect could be demonstrated when mice were infected with S. japonicum before challenge immunization with dinitrophenylated Sj (DNP-Sj). Moreover, BALB/c as well as C3H/He was a high responder to Sj in proliferation of peritoneal exudate T-lymphocyte enriched cells in vitro, whereas B10.S was not. Based on these observations, possible roles of Ir genes in immune responses to Sj are discussed.
D000818:Animals; D000941:Antigens / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D007114:Immunization; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D012549:Schistosoma japonicum / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000941:Antigens; D006183:H-2 Antigens; D007073:Immunoglobulin E