title: Fasting-induced impairment of glucose-1,6-bisphosphate synthesis in pancreatic islets.
abstract: In pancreatic islets removed from rats fasted for 48 hours, the insulin secretory response to glucose is decreased. Although the activity of phosphoglucomutase is unaffected by fasting, the decrease in glucose-stimulated insulin release coincides with a suppression of the glucose-induced increment in both glucose-1,6-P2 content and lactate or pyruvate output. These findings are compatible with a regulatory role of glucose-1,6-P2 in the control of glycolysis in pancreatic islets.
mesh_terms: D000818:Animals; D005215:Fasting; D005947:Glucose / Q000494:pharmacology; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000096:biosynthesis*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D010733:Phosphoglucomutase / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats
chemical_list: D005958:Glucosephosphates; D007328:Insulin; D007773:Lactates; D011506:Proteins; D011773:Pyruvates; D019344:Lactic Acid; D019298:Glucose-6-Phosphate; D019289:Pyruvic Acid; C016473:glucose-1,6-bisphosphate; D005969:Glutamate Dehydrogenase; D010733:Phosphoglucomutase; D005947:Glucose