[Effect of a controlled regimen of pyridoxol hydrochloride on the liver content of vitamin B6 and on the transaminase activities of erythrocytes in rats].
The pyridoxamine (PM), pyridoxal (PL) and pyridoxol (PN) in liver, the urinary excretion of 4-pyridoxic acid (4-PA), the red blood cells enzymatic activities (aspartate aminotransferase, GOT and alanine aminotransferase, GPT) were determined in rats fed diets containing different levels of PN, HCl (0,23-170 micrograms/rat/d) during 13 days. PL and PM hepatic levels, GOT and GPT activities decreased significantly in groups A and B receiving respectively 0,23 and 11 micrograms PN, HCl/rat/d. No differences were noticed in food intake and growth. The urinary excretion of 4-PA shows a consistent trend with vitamin B6 intake. As the PM/PL-ratio was maximum in group A, PL reflects the actually available vitamer, whereas PM should be regarded as "trapped" PL. The GOT and GPT activities can be considered as reliable parameters of the pyridoxine status of the rat.
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011730:Pyridoxal / Q000378:metabolism; D011733:Pyridoxamine / Q000378:metabolism; D011736:Pyridoxine / Q000378:metabolism* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011730:Pyridoxal; D011733:Pyridoxamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D011736:Pyridoxine
Effet d'un régime contrôle en chlorhydrate de pyridoxol et les teneurs hépatiques en vitamine B6 et sur les activités transaminasiques érythrocytaires chez le rat.