The action of substance P on contraction, inositol phospholipids and adenylate cyclase in rat small intestine.
The actions of substance P and eledoisin on contraction, [3H]inositol 1-phosphate and cAMP formation in the rat ileum have been compared. Eledoisin was considerably more potent than substance P on both contraction and [3H]inositol 1-phosphate production. Neither peptide altered the cAMP levels in the tissue. These results are discussed in relation to the substance P receptor sub-type present in the rat ileum, and its second messenger.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D004600:Eledoisin / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*
D010716:Phosphatidylinositols; D013373:Substance P; D004600:Eledoisin; D000262:Adenylyl Cyclases