title: Mutastein, a new inhibitor of adhesive-insoluble glucan synthesis by glucosyltransferases of Streptococcus mutans.
abstract: Mutastein, a new inhibitor of glucosyltransferases (GTase) of Streptococcus mutans, was isolated from cultural broth of Aspergillus terreus M3328. Mutastein was a heat-stable protein and was sensitive to pronase digestion. In the formation of glucans, that of adhesive water-insoluble glucans of S. mutans was specifically inhibited by mutastein.
mesh_terms: D001230:Aspergillus / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005656:Fungal Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D005936:Glucans / Q000096:biosynthesis*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors* / Q000502:physiology; D012995:Solubility; D013295:Streptococcus mutans / Q000201:enzymology*
chemical_list: D005656:Fungal Proteins; D005936:Glucans; C036864:Mutastein protein, Aspergillus terreus M3328; D005964:Glucosyltransferases