Thymoxamine versus pilocarpine in the reversal of phenylephrine-induced mydriasis.
Thymoxamine, a selective alpha-adrenergic blocker, was compared with pilocarpine in 19 patients for its reversal of phenylephrine-induced mydriasis. Both agents constricted the pupil to its original size in less than half an hour, and thymoxamine's half-life was twice that of pilocarpine's. The advantages of thymoxamine miosis, particularly in patients with narrow angles, are discussed.
D000328:Adult; D000368:Aged; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D013948:Moxisylyte / Q000494:pharmacology*; D010656:Phenylephrine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*
D010862:Pilocarpine; D010656:Phenylephrine; D013948:Moxisylyte