In vitro activity of norfloxacin in synthetic media and human urine compared to that of cinnoxacin, nalidixic acid and pipemidic acid.
Activity of norfloxacin was compared to that of cinnoxacin, nalidixic acid and pipemidi acid in DST-agar and human urine solidified by adding 1.2% agar. Norfloxacin was the most active compound when tested on DST-agar but the MIC values increased from 64 to 128 fold when tested in urine. Other compounds also showed an increase in MIC in urine-agar, but the increase was less marked. MICs for norfloxacin in DST-agar and Müller-Hinton-Agar were similar. Higher concentrations were required in Müller-Hinton-Broth than in Müller-Hinton-Agar.
D000362:Agar; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002937:Cinoxacin / Q000494:pharmacology*; D003470:Culture Media; D006801:Humans; D009268:Nalidixic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009643:Norfloxacin; D010876:Pipemidic Acid / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D014556:Urine
D000900:Anti-Bacterial Agents; D003470:Culture Media; D009539:Nicotinic Acids; D011724:Pyridazines; D009268:Nalidixic Acid; D000362:Agar; D002937:Cinoxacin; D010876:Pipemidic Acid; D009643:Norfloxacin