Differential cyclophosphamide sensitivity of T lymphocytes of the dengue virus-induced suppressor pathway.
Dengue type 2 virus (DV) induces a suppressor pathway in mice which involves sequential participation of three subpopulations of T lymphocytes viz. Ts1, Ts2 and T3 cells. In the present study cyclophosphamide (CY) sensitivity of these cells have been investigated. The findings of the present study demonstrate that Ts1 and Ts2 cells are CY-insensitive while T3 cells are CY-sensitive. This supports our earlier conclusion that T3 may be the inducer cells of suppression.
D000818:Animals; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000494:pharmacology*; D003715:Dengue / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology; D006462:Hemolytic Plaque Technique; D008222:Lymphokines / Q000096:biosynthesis; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology; D013491:Suppressor Factors, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000187:drug effects / Q000276:immunology*
D008222:Lymphokines; D013491:Suppressor Factors, Immunologic; D003520:Cyclophosphamide