title: Plasmodium berghei: a mouse model for the "sudden death" and "malarial lung" syndromes.
abstract: A mouse model for the "sudden death" and "malarial lung" syndromes is described. Mice of the C3H/z strain succumb suddenly approximately 7 days after an infection with Plasmodium berghei becomes patent, at a time when parasitemia is still moderate (6 to 8%). Death could be shown to be due to anaphylactoid shock, probably induced by soluble immune complexes. Increased vascular permeability caused transudation and leakage of serum proteins into the interstitium and the alveoli. The lungs were found to be edematous, with a fine granular precipitate in the alveoli and adherent to the vascular walls. The precipitates reacted with antiglobulins G and M, and could be shown to also contain malaria antigens and C3/4. A dramatic drop in hematocrit was recorded several hours before death, indicating the sudden release of malaria antigens. The myocardium of animals that had died very suddenly showed a patchy loss of phosphorylase activity. This loss of activity was much more extensive, and sometimes almost total, when there had been an agonal period of several (1 to 3) hours before death. In these cases the irreversibility of the myocardial damage was also indicated by the loss of activity of the dehydrogenases, as well as by typical inflammatory reactions of granulocytic and histiocytic infiltrations. The hearts thus presented a typical picture of the acute and peracute shock syndromes. In acute shock cardiac insufficiency develops so suddenly that death ensues before irreversible damage has occurred, and cardiac insufficiency can only be demonstrated by the most sensitive of enzyme histochemical means. In the present case shock was induced by the anaphylactoid activity of immune complexes with the lung as target organ. The described syndrome appears analogous to human "malarial lung."
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D003645:Death, Sudden / Q000209:etiology*; D004195:Disease Models, Animal; D005260:Female; D007105:Immune Complex Diseases / Q000209:etiology*; D008168:Lung / Q000276:immunology; D008171:Lung Diseases / Q000209:etiology*; D008288:Malaria / Q000150:complications* / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009206:Myocardium / Q000201:enzymology; D006005:Phosphorylases / Q000378:metabolism; D010962:Plasmodium berghei / Q000276:immunology; D012770:Shock, Cardiogenic / Q000209:etiology
chemical_list: D000936:Antigen-Antibody Complex; D006005:Phosphorylases