[Are suppressor T-cells the primary target cells of lead immunotoxicity?].
Studies were performed to investigate the effect of chronic low level lead exposure on the regulatory functions of T cells in the humoral immune response to sheep red blood cells (SRBC) in mice. Female mice were exposed to lead (as lead acetate) in the diet at 545 (group 1) and 2180 ppm (group 2) for 10 weeks. Lead exposure resulting in blood lead levels (PbB) of about 50 micrograms/100 g (group 1) produced a substantial increase of the number of IgG antibodies secreting spleen cells on days 3 and 4 after challenge. At the higher exposure level (group 2; PbB 60-80 micrograms/100 g) a suppression of the number of IgG plaque forming cells was observed. The IgM response was much smaller than the IgG response. Although differences between the group means were small, the results indicate that there also is an enhancement of the IgM response in the lower dosage group on days 3 and 4. In a second experiment the effect of in vivo lead exposure on antigenic competition was examined. Lead substantially reduced the effect of antigenic competition. Results of both experiments suggest that suppressor T cells rather than helper T cells may represent the primary target for lead. Throughout this study serum complement C3 levels were determined. Complement C3 levels tended to be reduced in the lead exposed groups before as well as after inocculation with SRBC.
D000818:Animals; D000915:Antibody Affinity / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects*; D003176:Complement C3 / Q000378:metabolism; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006462:Hemolytic Plaque Technique; D006736:Horses / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007854:Lead / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds; D012756:Sheep / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate
Sind Suppressor-T-Zellen die primären Zielzellen der immunotoxischen Wirkungen von Blei?