title: Death due to splenic rupture in suppressor cell mycosis fungoides: a case report.
abstract: A case of mycosis fungoides in which pathologic rupture of the spleen led to intraperitoneal hemorrhage and death is described. To our knowledge, splenic rupture has not been reported previously as a cause of death in mycosis fungoides. Immunologic studies demonstrated that the neoplastic cell was a suppressor/cytotoxic T-cell. In most cases of mycosis fungoides or the Sézary syndrome, the neoplastic cell has been a helper/inducer T-cell. This case was very aggressive clinically with prominent visceral involvement and suggests that mycosis fungoides may be clinically diverse as well as immunologically heterogeneous.
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D009182:Mycosis Fungoides / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D013161:Splenic Rupture / Q000401:mortality / Q000473:pathology*; D050378:T-Lymphocytes, Regulatory / Q000473:pathology*; D013714:Tennessee