title: Effects of sub-lethal concentrations of the antimicrobial agent propylene phenoxetol on the growth and extracellular enzymes of Propionibacterium acnes.
abstract: Propionibacterium acnes was grown in continuous culture in the presence of propylene phenoxetol. At sub-lethal concentrations of this antimicrobial agent (0.025-0.1% w/v) steady-state growth conditions were achieved. In comparison with the control, cell biomass, maximum specific growth rates and levels of the extracellular lipase and hyaluronate-lyase, decreased with increasing concentrations of propylene phenoxetol. Levels of protease activity remained approximately constant whilst production of acid phosphatase was significantly increased with increasing propylene phenoxetol concentrations. At the highest concentration of the antimicrobial agent (0.2% w/v) growth was completely inhibited.
mesh_terms: D000135:Acid Phosphatase / Q000096:biosynthesis; D000152:Acne Vulgaris / Q000188:drug therapy / Q000382:microbiology; D002455:Cell Division / Q000187:drug effects; D005026:Ethylene Glycols / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008049:Lipase / Q000096:biosynthesis; D010447:Peptide Hydrolases / Q000096:biosynthesis; D011133:Polysaccharide-Lyases / Q000096:biosynthesis; D011425:Propionibacterium acnes / Q000187:drug effects* / Q000201:enzymology; D012874:Skin Diseases, Infectious / Q000188:drug therapy
chemical_list: D005026:Ethylene Glycols; C016697:propylene phenoxetol; D008049:Lipase; D000135:Acid Phosphatase; D010447:Peptide Hydrolases; D011133:Polysaccharide-Lyases; C100002:hyaluronate lyase