[Sodium dodecyl sulfate, concurrent inhibitor of several dehydrogenases].
The effect of sodium dodecyl sulfate on the activity of highly purified or crystalline enzymes has been studied. The enzymes were: lactate dehydrogenase (LDH), malate dehydrogenase (MDH). isocitrate dehydrogenase (ICDH), glucose-6-phosphate dehydrogenase (G6P-DH), lipase, alkaline phosphatase. Sodium dodecyl sulfate, always under the critical micellar concentration, shows a selective inhibitory effect. A kinetic analysis of the inhibitory action on LDH, MDH, ICDH and G6P-DH was also carried out.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors; D000818:Animals; D002417:Cattle; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors; D007422:Intestines / Q000201:enzymology; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors; D008049:Lipase / Q000037:antagonists & inhibitors; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011817:Rabbits; D012233:Rhizopus / Q000201:enzymology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology*; D013552:Swine
D012967:Sodium Dodecyl Sulfate; D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D008049:Lipase; D000469:Alkaline Phosphatase
Le dodécylsulfate de sodium, inhibiteur concurrent de quelques déshydrogénases.