Effect of mepyramine on the untoward side-effects of impromidine.
The value of impromidine, a potent histamine H2-receptor agonist, as an effective acid-secretory stimulant is limited by its tendency to cause cardiovascular side-effects. The possibility that the latter may be mediated not only by H2-receptors in the heart and peripheral blood vessels but also by overflow stimulation of H1-receptors was investigated in a double-blind study using impromidine with or without the H1-antagonist, mepyramine maleate. There was no significant difference between the two groups, suggesting that the side-effects are mediated by H2-receptors in the cardiovascular system alone.
D000631:Aminopyridines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D005483:Flushing; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D017446:Impromidine; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D011738:Pyrilamine / Q000494:pharmacology*; D011897:Random Allocation; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*
D000631:Aminopyridines; D007093:Imidazoles; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D017446:Impromidine; D011738:Pyrilamine