Regulation of hepatocyte proliferation. The feed-back system of hepatopoietin.
After partial hepatectomy the low proliferation rate of hepatocytes increases dramatically. This is based on a feed-back system whose central link is a liver cell proliferation hormon, the so-called hepatopoietin. The hormon originates from the Peyer's patches: after their resection, the liver cell proliferation after partial hepatectomy decreases by about 80%. Hepatopoietin effects organ specific but species nonspecific.
D000818:Animals; D001798:Blood Proteins / Q000502:physiology*; D002455:Cell Division; D004261:DNA Replication; D005246:Feedback; D017228:Hepatocyte Growth Factor; D008099:Liver / Q000166:cytology / Q000502:physiology*; D008115:Liver Regeneration
D001798:Blood Proteins; D017228:Hepatocyte Growth Factor