Cutaneous lymphomatoid granulomatosis: a rare cause of recurrent skin ulceration.
We report the case of a 34-year-old male who presented with recurrent skin ulceration due to lymphomatoid granulomatosis. Monoclonal antibody studies showed a high T helper (T4):T suppressor (T8) cell ratio in both the lesions and the peripheral blood. Plasma cells in the infiltrate showed IgA lambda staining but as yet no monoclonal immunoglobulin has been identified in the blood or urine. Lymphocytes bearing markers of immature cells (T10) were observed in the tissue and blood.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D006801:Humans; D008230:Lymphomatoid Granulomatosis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D012008:Recurrence; D012871:Skin Diseases / Q000150:complications* / Q000276:immunology / Q000473:pathology; D012883:Skin Ulcer / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal