Species differences in zearalenone-reducing activity in subcellular fractions of liver from female domestic animals.
The subcellular distribution of the zearalenone-reducing activity in liver from female pig, goat, sheep, cow and hen was investigated. The distribution patterns for the reduction of zearalenone to alpha- or beta-zearalenol differed between species and was also dependent upon coenzyme. Pig and goat had the greatest ability to form both alpha- and beta-zearalenol in the microsomal fraction independently of coenzyme. Cow and hen formed alpha-zearalenol almost entirely in the microsomal fraction and beta-zearalenol only in the cytosol fraction and only with NADPH as coenzyme. The sheep was distinct from the pig and goat in having the highest alpha-zearalenol forming activity in the cytosol fraction when NADPH was used as coenzyme.
D000818:Animals; D002417:Cattle; D002645:Chickens; D005260:Female; D006041:Goats; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010084:Oxidation-Reduction; D012118:Resorcinols / Q000378:metabolism*; D012756:Sheep; D013045:Species Specificity; D013347:Subcellular Fractions / Q000378:metabolism*; D013552:Swine; D015025:Zearalenone / Q000378:metabolism*
D012118:Resorcinols; D015025:Zearalenone; D007770:L-Lactate Dehydrogenase; D009251:NADPH-Ferrihemoprotein Reductase