Does mitochondrial ATP synthesis decline as a function of change in the membrane environment with ageing.
Cardiac mitochondria isolated from rats fed purified diets of known lipid composition demonstrate a decline in the rates of oxidative phosphorylation, ATP synthesis and oligomycin sensitive ATPase activity as the animal ages. Transitions in these lipid-dependent functions of mitochondrial energy metabolism are concomitant with changes in the lipid environment of the mitochondrial membrane.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000375:Aging; D000818:Animals; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D051381:Rats
D008563:Membrane Lipids; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases