title: [Experience with lamoxactam in gynecology: application as a monotherapeutic agent in severe genital infections and determination of its concentration in uterine and tubal tissues].
abstract: In 30 patients with genital infections of different etiology and high fever lamoxactam was used as a single agent antibiotic. In 90% of the cases the treatment was successful. The antibiotic did not need to be changed in any of the cases. The determination of the lamoxactam concentration in the uterus and the fallopian tubes after a single dose of 2 grams pre-operatively at various times showed high tissue levels for a prolonged period of time. The concentrations were still higher 6 hours after the single dose than the in vitro MHK values for most bacteria important in gynaecological infections.
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D002511:Cephalosporins / Q000008:administration & dosage*; D002513:Cephamycins / Q000008:administration & dosage* / Q000032:analysis; D004716:Endometritis / Q000188:drug therapy; D005187:Fallopian Tubes / Q000032:analysis; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009070:Moxalactam; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy; D014599:Uterus / Q000032:analysis
chemical_list: D002511:Cephalosporins; D002513:Cephamycins; D009070:Moxalactam
vernacular_title: Erfahrungen mit Lamoxactam in der Gynäkologie: Einsatz als Monotherapeutikum bei schweren genitalen Infektionen und Konzentrationsspiegelbestimmungen im Uterus- und Tubengewebe.