[Effects of adenosine on the secretions of glucagon and insulin of isolated ad perfused pancreas of the rat].
The effects of adenosine on insulin and glucagon secretions were studied using the isolated perfused rat pancreas. The secretion of glucagon was stimulated by adenosine at concentrations ranging from 1.65 to 165 mumol/l, in the presence of glucose 0.5 g/l; the stimulation was immediate, but transient and was dose-dependent. Insulin secretion was not changed by adenosine in the presence of glucose 0.5 g/l; in the presence of glucose 1.5 g/l, adenosine at 1.65 and 16.5 mumol/l did not significantly modify insulin secretion. But at 165 mumol/l adenosine induced a progressive increase in time after the 5th minute. The A cell appears then to be much more sensitive to adenosine than the B cell.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D005934:Glucagon / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010179:Pancreas / Q000378:metabolism*; D051381:Rats
D007328:Insulin; D005934:Glucagon; D000241:Adenosine
Effets de l'adénosine sur les sécrétions de glucagon et d'insuline du pancréas isolé et perfusé du rat.