title: [Monotherapy with clobazam in epilepsies in children].
abstract: Twenty-five epileptic children were treated with clobazam alone for periods of 10 days to 36 months (mean = 9 months and 16 months for children who responded well). Satisfactory results were obtained in 11 patients and marked improvement with a 75% decrease in the initial frequency of seizures in 6 patients. The seizures recurred after a few weeks in 3 other patients. This preliminary study shows that clobazam is well tolerated and remarkably effective, especially in benign partial epilepsy, even in carbamazepine-resistant cases.
mesh_terms: D000293:Adolescent; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000097:blood / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D000078306:Clobazam; D004828:Epilepsies, Partial / Q000188:drug therapy; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000078306:Clobazam
vernacular_title: Monothérapie par le clobazam dans les épilepsies de l'enfant.