Sister-chromatid exchange (SCE) analysis in mothers exposed to DNA-damaging agents and their newborn infants.
The incidence of SCE in the lymphocytes of mothers and their newborn infants was determined. A detailed antenatal history of parental habits such as smoking, alcohol consumption and possible exposure to DNA-damaging agents was documented. The results showed that the SCE rate in the newborn is significantly less than that of their mothers. Mothers who consumed alcohol, but not cigarette smokers, had a significantly increased SCE rate compared to control mothers. However, these maternal habits did not affect the SCE rate of their infants. Neonates with neural tube defects showed a significantly increased SCE rate compared to normal babies.
D000015:Abnormalities, Multiple / Q000235:genetics; D000428:Alcohol Drinking; D003434:Crossing Over, Genetic; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000235:genetics; D011247:Pregnancy; D012854:Sister Chromatid Exchange; D012907:Smoking