title: Increased phospholipid methylation in the myocardium of alcoholic rats.
abstract: Phospholipid methyltransferase activity is unevenly distributed throughout the contractile and the specialized regions of rat heart. Chronic alcohol treatment stimulated the incorporation of [3H-methyl]-methionine but not [3H-methyl]-choline into phosphatidylcholine by left ventricular slices. The increase in the incorporation of [3H-methyl]-group from [3H-methyl]-methionine into phosphatidylcholine was due to an increase in phospholipid methyltransferase activity.
mesh_terms: D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006801:Humans; D008297:Male; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D050941:Phosphatidyl-N-Methylethanolamine N-Methyltransferase; D010713:Phosphatidylcholines / Q000096:biosynthesis; D050918:Phosphatidylethanolamine N-Methyltransferase; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010713:Phosphatidylcholines; D010743:Phospholipids; D008780:Methyltransferases; D050918:Phosphatidylethanolamine N-Methyltransferase; D050941:Phosphatidyl-N-Methylethanolamine N-Methyltransferase; D000252:Calcium-Transporting ATPases; D002118:Calcium