Failure to antagonize the 8-hydroxy-2-di-n-propylamino)tetralin-induced facilitation of male rat sexual behavior by the administration of 5-HT receptor antagonists.
The administration of the putative 5-hydroxytryptamine (5-HT) agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-hydroxytryptophan (5-HTP) produced a facilitation and an inhibition of male rat sexual behavior, respectively. The 5-HTP-induced inhibitory effects were at least partially antagonized by the administration of metergoline, methiothepine or pirenperone. However, none of these agents were able to counteract any facilitatory effects produced by 8-OH-DPAT. It is concluded that 8-OH-DPAT does not facilitate the expression of masculine sexual behavior in the rat by stimulation of 5-HT1 or 5-HT2 receptors.
D006916:5-Hydroxytryptophan / Q000037:antagonists & inhibitors / Q000494:pharmacology; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D005260:Female; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D008719:Methiothepin / Q000494:pharmacology; D009281:Naphthalenes / Q000037:antagonists & inhibitors*; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D009281:Naphthalenes; D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013764:Tetrahydronaphthalenes; D008711:Metergoline; D008719:Methiothepin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D006916:5-Hydroxytryptophan; C034177:pirenperone