Effects of profadol on operant behavior in the pigeon.
The effects of profadol were determined on the key pecking of pigeons under the control of a multiple fixed-ratio, fixed-interval schedule of grain presentation. The effects of naloxone and pentobarbital on the behavioral suppression produced by profadol were also determined. Profadol (0.64-10 mg/kg) decreased responding under both schedule components, and the decrease in responding could not be reversed by either naloxone or pentobarbital. A moderate dose of profadol (1.25 mg/kg) was ineffective as an antagonist of morphine (20 mg/kg). Profadol does not produce its behavioral effects in pigeons by an action with a naloxone-sensitive opioid receptor and its non-opioid behavioral effects are dissimilar to those of previously studied meperidine-like phenylpiperidine analgesics.
D000818:Animals; D010856:Columbidae; D003216:Conditioning, Operant / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors; D009270:Naloxone / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D012055:Reinforcement Schedule
D011759:Pyrrolidines; D009270:Naloxone; D009020:Morphine; D010424:Pentobarbital