Multiple side effects of penicillamine therapy in one patient with rheumatoid arthritis.
Skin rashes, proteinuria, systemic lupus erythematosus, polymyositis and myasthenia gravis have all been recorded as complications of penicillamine therapy in patients with rheumatoid arthritis. A patient who had developed all 5 is now described. The skin lesion resembled elastosis perforans serpiginosa, which has been reported as a rare side effect in patients with Wilson's disease but not in patients with rheumatoid arthritis treated with penicillamine.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003875:Drug Eruptions / Q000209:etiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced; D008297:Male; D009157:Myasthenia Gravis / Q000139:chemically induced; D009220:Myositis / Q000139:chemically induced; D010396:Penicillamine / Q000009:adverse effects*; D011507:Proteinuria / Q000139:chemically induced
D010396:Penicillamine