Preservation of T-lymphocyte activity in autoimmune MRL-lpr mice treated with prostaglandin.
MRL-lpr mice display immunoregulatory disturbances which are related to an early massive T-lymphocyte hyperplasia. Features of autoimmunity are rapidly progressive and these animals die from immune complex-mediated glomerulonephritis. Previous studies show that 15 methyl prostaglandin E1 (PGE) treatment in MRL-lpr mice prolongs survival by preventing lymphoproliferation and the subsequent renal disease. The present study indicates that a major activity of this therapy stabilizes several T-cell functions. Both the age-related loss of the autologous mixed-lymphocyte reaction (AMLR) (Ly1+ 2,3- dependent) and the concanavalin A-induced suppressor cell activity (Ly1- 2,3+ dependent) remain intact. It is suggested that PGE preserves these T-cell functions by maintaining a more normal balance of T-cell subsets.
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D000936:Antigen-Antibody Complex; D001327:Autoimmune Diseases / Q000276:immunology*; D002478:Cells, Cultured; D003208:Concanavalin A; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000936:Antigen-Antibody Complex; D011459:Prostaglandins E, Synthetic; D003208:Concanavalin A; C025170:15(S)-15-methylprostaglandin E1; D000527:Alprostadil