Relationship between lymphocyte proliferation and migration inhibitory factor production in response to autologous tumor extract in cancer patients.
In forty-nine patients with various carcinomas, cell-mediated immune response to 3M KCl extract of autologous tumor was studied with the use of both lymphocyte proliferation (LP) assay and macrophage migration inhibition (MMI) assay simultaneously. There was no correlation between stimulation index in LP assay and migration index in MMI assay in these simultaneous tests. The results of this study indicate dissociation between cell proliferation and migration inhibitory factor production of lymphocytes in response to autologous tumor extract in patients with various carcinomas.
D001943:Breast Neoplasms / Q000276:immunology; D002464:Cell Migration Inhibition; D003110:Colonic Neoplasms / Q000276:immunology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D008264:Macrophages / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D013274:Stomach Neoplasms / Q000276:immunology