The maximum capacity of glycolysis in brown adipose tissue and its relationship to control of the blood glucose concentration.
The maximum activity of the key glycolytic enzymes, hexokinase and 6-phosphofructokinase, was measured in tissues of control and cold-acclimated rats. The only significant change in activity was seen in brown adipose tissue where the activity of these enzymes was increased 2-fold. This increase in glycolytic capacity along with the hypertrophy of BAT observed in cold acclimation suggests that this tissue could play an important role in glucose utilisation by the rat.
D000064:Acclimatization; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003080:Cold Temperature; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D010732:Phosphofructokinase-1 / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D006593:Hexokinase; D010732:Phosphofructokinase-1