title: Drug eruptions presenting at sites of prior radiation damage (sunlight and electron beam).
abstract: Two patients are described in whom sunburn and electron beam radiodermatitis, respectively, were critical determinants in localizing the initial presentation of drug eruptions. In the first instance, a severe sunburn of the back and thighs was followed 7 months later by the appearance of a toxic epidermal necrolysis drug reaction to trimethoprim-sulfamethoxazole in the exact sites of the previous bullous sunburn reaction. In the second patient, a radiodermatitis of the left upper arm due to electron beam therapy for metastatic breast cancer was followed 7 weeks later by a codeine drug reaction confined to the area of the radiodermatitis. In both instances, oral rechallenge with the offending drug reproduced the eruption.
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000532:radiotherapy; D003061:Codeine / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011855:Radiodermatitis / Q000150:complications*; D012867:Skin / Q000473:pathology; D013420:Sulfamethoxazole / Q000009:adverse effects*; D013471:Sunburn / Q000150:complications*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D003061:Codeine