[Clinico-morphological characteristics of the sequelae of the parenteral administration of gemodes and polyglucin to children].
In 38 dead children and in a resected lung of an operated child, the alterations were discovered, connected with accumulation in tissues of hemodez and polyglucin after their parenteral administration. The same picture of the so-called iatrogenic thesaurosis was reproduced in 16 rabbits that received the above preparations intravenously. Three degrees of accumulation were distinguished which directly depended on the dose and time of synthetic plasma substituents administration, both on clinical and experimental material. It is recommended to take into consideration the alterations revealed in this study in the diagnosis of some enzymo- and lymphadenopaties, giant-cell vasculitis, and granulomatous processes. The secondary immunodeficiency is suggested in children with iatrogenic thesaurosis, on the basis of the disease histories and morphological data.
D000818:Animals; D002675:Child, Preschool; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D007223:Infant; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced* / Q000473:pathology; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000009:adverse effects*; D011205:Povidone / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution
D003911:Dextrans; D010952:Plasma Substitutes; C007918:hemodes; D011205:Povidone
Kliniko-morfologicheskaia kharakteristika posledstviĭ parenteral'-nogo vvedeniia detiam gemodeza i poligliukina.