title: [Pigmented exanthema after spironolactone allergy in progressive systemic scleroderma].
abstract: A 37-year-old man developed generalized medium-brown hyperpigmentation in the course of progressive systemic scleroderma. Histologically there were numerous Melanin granules in the basal epidermis, but also in the upper Malpighian layer and in corneocytes. An allergic rash developed on administration of spironolactone given for the scleroderma. After healing there remained slate-grey spots. As a consequence of the drug rash the already present hyperpigmentation was aggravated by marked pigment deposition in the upper corium. At the same time there were numerous melanophages as sign of an absorptive removal of the melanin granules. The drug allergy was thus the occasion for the persisting pigment deposition with circumscribed spotty pigmentation of the skin.
mesh_terms: D000328:Adult; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000150:complications* / Q000209:etiology; D006801:Humans; D008297:Male; D010859:Pigmentation Disorders / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000150:complications*; D012867:Skin / Q000473:pathology; D013148:Spironolactone / Q000009:adverse effects*
chemical_list: D013148:Spironolactone
vernacular_title: Pigmentexanthem nach Spironolacton-Allergie bei progressiver systemischer Sklerodermie.