[Effect of flurbiprofen and acetylsalicylic acid on the ultrastructure of blood platelets].
Flurbiprofene or acetylsalicylic acid did not change the structure of inactivated platelets. With flurbiprofene 50% aggregation inhibition was obtained at 10(-6) to 10(-5) M concentrations. To obtain the same result with acetylsalicylic acid, 10(-4) to 10(-3) M concentrations were necessary. With both agents, shape change was inhibited. The platelets in the small aggregates did not have the normal stretched dumb-bell shape but remained globulous and emitted a broad pseudopode containing normally-repolymerized microtubules.
D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D005480:Flurbiprofen / Q000494:pharmacology*; D006801:Humans; D008854:Microscopy, Electron; D011422:Propionates / Q000494:pharmacology*
D011422:Propionates; D005480:Flurbiprofen; D001241:Aspirin
Effet du flurbiprofène et de l'acide acétylsalicylique sur l'ultrastructure des plaquettes sanguines.