Premature closure of the foramen ovale and hypoplasia of the left heart.
Although premature closure of the foramen ovale has been proposed as a possible cause of hypoplastic left heart syndrome, very few such cases have been described. We have seen two examples of the combination and no associated malformations. In both the foramen was firmly closed on its left atrial aspect and the dimensions of the left sided structures were well below normal values.
D006332:Cardiomegaly / Q000151:congenital* / Q000209:etiology; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male