[Inhibition of prolactin secretion and androgenic function in the adult male rat].
The effects of bromocriptine induced hypoprolactinemia on the testicular function were studied in adult rats. Bromocriptine treatment (1500 micrograms/day for 24 days) reduced serum and pituitary Prolactin levels, indicating a decrease in prolactin secretion and synthesis. No change in reproductive organ weights was seen in treated animals. Hypoprolactinemia had no effect on plasma testosterone or androstenedione levels and testicular androstenedione content, but decreased significantly testicular testosterone content. These findings indicated that experimental hypoprolactinemia induced a decrease in testicular testosterone content without affecting androgens levels.
D000728:Androgens / Q000097:blood*; D000735:Androstenedione / Q000097:blood; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation; D013737:Testis / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D000728:Androgens; D001971:Bromocriptine; D013739:Testosterone; D000735:Androstenedione; D011388:Prolactin
Freination de la sécrétion de prolactine et fonction androgénique chez le rat mâle adulte.