[Antibacterial activity of N-formimidoyl-thienamycin in comparison with other beta-lactam antibiotics against clinical problem strains (author's transl)].
The efficacy of N-formimidoyl-thienamycin (MK 0787) has been tested against 549 cultures of different species, which often cause therapeutic problems. Included were 286 mezlocillin-resistant strains, 100 Serratia marcescens and 66 Pseudomonas aeruginosa. The minimal inhibitory concentration ranged between 0.06 and 4 micrograms/ml by means of the agar-dilution-method. Resistant strains were not observed. Among the 11 beta-lactam- and aminoglycoside-antibiotics tested N-formimidoyl-thienamycin was the most effective with the broadest spectrum.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology; D015378:Imipenem; D008802:Mezlocillin; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D013045:Species Specificity; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010406:Penicillins; D047090:beta-Lactams; D015378:Imipenem; D008802:Mezlocillin
Antibakterielle Aktivität von N-Formimidoyl-thienamycin im Vergleich zu anderen beta-Laktam-Antibiotika bei klinischen Problembakterien.