Strong association between IgA nephropathy and HLA-DR4 antigen.
Although the etiology and pathogenesis of IgA nephropathy is not fully understood, it has been classified as an immune-complex induced glomerulonephritis caused by an immunological mechanism. Forty-two patients with primary IgA nephropathy underwent tissue typing for HLA-A, B, and DR antigens by the standard method using a microlymphocytotoxicity test. There was no significant correlation between HLA-A and B antigens and this disease. However, the frequency of HLA-DR4 was 57.1% in the patients with normal renal function, 85.7% in those with decreased renal function, 100% in dialysis patients, and 39.2% in the control group. It is statistically significant in the patients with renal dysfunction (corrected P less than 0.05). Our results suggest that the HLA system may play an important role in the occurrence and exacerbation of IgA nephropathy in the Japanese population.
D000293:Adolescent; D000328:Adult; D005260:Female; D005455:Fluorescent Antibody Technique; D005838:Genotype; D005921:Glomerulonephritis / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007105:Immune Complex Diseases / Q000235:genetics / Q000276:immunology*; D007070:Immunoglobulin A / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D006680:HLA Antigens; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D007070:Immunoglobulin A