Norfloxacin--a review of pharmacology and tissue penetration.
A review of the pharmacokinetics of the highly active quinoline derivative, norfloxacin, is presented. The compound appears to be rapidly absorbed. The serum half-life is about 3 X 5 h and 30% of a given dose is recovered in the urine. Rapid penetration of an inflammatory exudate occurs. The compound is metabolized to a modest extent, probably in the liver, six metabolites being recognized. The serum half-life is prolonged in severe renal impairment. Probenecid would appear to decrease the renal elimination. The possibility of treating both urinary and tissue infections with this compound is raised.
D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000378:metabolism*; D001711:Biotransformation; D006801:Humans; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D009268:Nalidixic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D009643:Norfloxacin; D014018:Tissue Distribution
D000892:Anti-Infective Agents, Urinary; D009268:Nalidixic Acid; D009643:Norfloxacin