title: Morphological behaviour of lympho-myeloid organs at experimental stimulation with leukotrophine.
abstract: The influence of leukotrophine on the behaviour of lymphomyeloid organs was studied in male Swiss mice aged 2 months. In the four comparatively studied groups it was shown that leukopoiesis and immune maturation was slightly stimulated by leukotrophine or protected by thiola, a radioprotective substance; the administration of both substances, leukotrophine + thiola, enhances the two actions, myelo-lymphoid leukopoiesis and cellular pyroninophilia, almost doubling them. Histochemical studies were supplemented with histoenzymatic and cytogenetic investigations.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D001854:Bone Marrow Cells; D007121:Immunocompetence / Q000187:drug effects*; D008221:Lymphoid Tissue / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011837:Radiation-Protective Agents / Q000494:pharmacology; D013949:Thymus Extracts / Q000494:pharmacology*; D008625:Tiopronin / Q000494:pharmacology
chemical_list: D011837:Radiation-Protective Agents; D013949:Thymus Extracts; C024817:leukotrophin; D008625:Tiopronin