[Intolerance to cow's milk. Study of specific immunoglobulin E].
IgE's specifically directed against alpha-lactalbumin, beta-lactoglobulin and casein were evaluated in the sera of 164 children aged between 8 days and 3 years, suspected of intolerance to cow's milk. In addition to these three RAST's for single allergens, a "total cow's milk proteins" RAST was performed. Intolerance was detected in 107 out of 180 sera tested, with at least one of the RAST's being positive. The two specific allergens most frequently involved were alpha-lactalbumin and beta-lactoglobulin. However, these proved curiously less sensitive than the "total allergen", which makes the use of these tests of little interest as a rule. A highly significant positive correlation was found between total IgE's and positivity of the four RAST's.
D000818:Animals; D002417:Cattle; D002675:Child, Preschool; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008892:Milk / Q000009:adverse effects / Q000276:immunology*; D008894:Milk Proteins / Q000276:immunology / Q000378:metabolism; D011852:Radioallergosorbent Test
D008894:Milk Proteins; D007073:Immunoglobulin E
Les intolérances au lait de vache. Etude des immunoglobulines E spécifiques.