Cells with immunoregulatory function: the human macrophages and the effects of remittive drugs.
Different inhibitory effects on the mixed leukocyte reaction were noted with sodium aurothiomalate (GSTM) and D-penicillamine (D-Pen) depending on the lymphocyte/macrophage ratio of responder cell populations. GSTM and auranofin strongly inhibited oxy radical generation whereas D-Pen had a selective effect.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006046:Gold / Q000031:analogs & derivatives*; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use*; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D010396:Penicillamine / Q000627:therapeutic use*
D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold; D010396:Penicillamine