Some T-cell functions in patients with viral myocarditis. The effect of polymorphonuclear leukocyte (PMNL) lysosome factors on T-suppressor cell activity in vitro.
The in vitro increase in mitogenic potency of lysosome factors derived from peripheral blood granulocytes of patients with chronic viral myocarditis was observed. These factors inhibited in vitro the Con A-induced suppressor cell activity measured in lymphocytes from healthy persons. The obtained results suggested that these factors may cause disturbances in suppressor cell function in the course of the foregoing disease.
D000328:Adult; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D008934:Mitogens; D009205:Myocarditis / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D008934:Mitogens; D003208:Concanavalin A