Alcohol-induced rosacea flushing blocked by naloxone.
We evaluated the roles of endogenous opioid peptides and histamine in the pathophysiology of alcohol-induced facial flushing in rosacea. Non-diabetic patients with rosacea ingested 360 ml of 6% ethanol after receiving either subcutaneous naloxone hydrochloride or oral chloropheniramine maleate. Only pretreatment with naloxone blocked the alcohol-induced rosacea flushing (AIRF), suggesting an active role of endogenous enkephalin and/or endorphin in this vascular reactivity. In this respect, AIRF is similar to chlorpropamide alcohol flushing and menopausal flushing.
D000328:Adult; D000434:Alcoholic Beverages / Q000009:adverse effects*; D002744:Chlorpheniramine / Q000494:pharmacology; D004311:Double-Blind Method; D005145:Face; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology*; D012393:Rosacea / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
D009270:Naloxone; D002744:Chlorpheniramine