title: Nephrotoxicity following single dose mithramycin therapy.
abstract: Mithramycin given as a single dose for the treatment of hypercalcemia has not been reported to cause renal dysfunction. A case is presented of nephrotoxicity following a single 25 micrograms/kg dose in a patient with underlying squamous cell carcinoma, obstructive uropathy, and hypercalcemia. Underlying renal impairment may magnify the nephrotoxicity of mithramycin.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy; D009362:Neoplasm Metastasis; D008926:Plicamycin / Q000009:adverse effects* / Q000627:therapeutic use; D014517:Ureteral Obstruction / Q000150:complications; D002583:Uterine Cervical Neoplasms / Q000150:complications
chemical_list: D008926:Plicamycin