The antidepressant agents desipramine, fluoxetine, fluvoxamine and norzimelidine inhibit uptake of [3H]noradrenaline and [3H]5-hydroxytryptamine in slices of human and rat cortical brain tissue.
The stability of uptake of [3H]noradrenaline and [3H]5-hydroxytryptamine in rat neocortical brain slices, prepared up to 4-5 h after decapitation, was established. Subsequently, monoamine uptake inhibition by 4 antidepressant agents: desipramine, fluoxetine, fluvoxamine and norzimelidine was compared in human post-mortem neocortical brain slices vs rat neocortical brain slices. In both species, desipramine exhibited considerable selectivity for noradrenaline uptake, while fluoxetine, fluvoxamine and norzimelidine showed varying degrees of selectivity for 5-hydroxytryptamine uptake. These results support the use of rat brain as a model for the study of neurochemical correlates of depression and antidepressant drug action.
D000042:Absorption; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D016666:Fluvoxamine; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010091:Oximes / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D015031:Zimeldine / Q000031:analogs & derivatives / Q000494:pharmacology
D000928:Antidepressive Agents; D010091:Oximes; D005473:Fluoxetine; D012701:Serotonin; D015031:Zimeldine; C017578:norzimelidine; D016666:Fluvoxamine; D003891:Desipramine; D009638:Norepinephrine