title: [Effects of 5023 SE on PaO2 at rest in elderly patients with cerebral impairment. A double-blind cross-over trial versus placebo].
abstract: In a double-blind cross-over study, the effects of Duxil on blood gases at rest were compared to those of a placebo in 39 elderly patients (mean age: 74.8 years). The study lasted 6 months divided into two 3-month periods. A mean increase of 2.10 mmHg in PaO2 was observed in patients under Duxil, the difference with the results obtained under placebo being statistically significant (p less than 0.01). At that dosage level, Duxil may therefore be considered an active treatment of hypoxia associated with old age.
mesh_terms: D000368:Aged; D015765:Almitrine; D001927:Brain Diseases / Q000097:blood / Q000188:drug therapy*; D003704:Dementia / Q000097:blood / Q000188:drug therapy; D004311:Double-Blind Method; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D015016:Yohimbine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D010879:Piperazines; D015016:Yohimbine; C037558:almitrine, raubasine drug combination; D015765:Almitrine; D010100:Oxygen
vernacular_title: Effets du 5023 SE sur la PaCO2 de repos chez des sujets âgés insuffisants cérébraux. Essai croisé à double insu contre placebo.