Radiosensitizing effects of misonidazole and SR 2508 on a human melanoma transplanted in nude mice: influence on repair of potentially lethal damage.
The radiosensitizing effects of misonidazole and SR 2508 (1 mg/g) were compared on a human melanoma (Na11) containing 85% hypoxic cells transplanted into nude mice. For both drugs, the enhancement ratios (ER) were 1.7 after immediate plating and 2.1 after delayed plating. This difference in ERs is related to a lack of PLD repair in tumors in the presence of the sensitizer. The effect of misonidazole was also investigated in another human melanoma (Be11) containing 40% hypoxic cells. After immediate plating, the ER was similar to that observed with the Na11 tumor (1.7), but PLD repair was not reduced. A comparative analysis of the influence of misonidazole on the response (survival curve - PLD repair) of Na11 melanoma to different ionizing radiations was attempted.
D000818:Animals; D002460:Cell Line; D017341:Etanidazole; D005260:Female; D008545:Melanoma / Q000532:radiotherapy*; D051379:Mice; D008819:Mice, Nude; D008920:Misonidazole / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D017341:Etanidazole; D008920:Misonidazole