Ultrastructural demonstration of retrovirus antigens with immuno-gold staining in prodromal acquired immune deficiency syndrome.
The peripheral lymphocytes of a patient with prodromal acquired immune deficiency syndrome contained giant multivesicular bodies. These were specifically stained by immuno-gold labelled polyclonal antibodies against the major core protein p24 of bovine leukaemia virus and human T cell leukaemia virus I. Moreover, the patient's serum was positive for bovine leukaemia virus by the ELISA method.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000914:Antibodies, Viral; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000032:analysis*; D017977:Deltaretrovirus / Q000276:immunology; D005260:Female; D006046:Gold; D006801:Humans; D001909:Leukemia Virus, Bovine / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008854:Microscopy, Electron; D008875:Middle Aged; D012190:Retroviridae / Q000276:immunology*; D013194:Staining and Labeling
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006046:Gold