Effects of mercurial compounds on adenine nucleotides of washed pig platelets.
The effects of methylmercuric chloride, mercuric chloride, and phenylmercuric acetate (10(-6) - 10(-3) mole/liter) on thrombin-induced release of adenine nucleotides from washed pig platelets were investigated. The inhibitory effects of mercurials were always reached when the higher thrombin concentration (0.74 units NIH/ml) was used. Incubation of washed pig platelets with methylmercuric chloride caused a decrease of intracellular level of platelet ATP and statistically significant changes in ATP/ADP ratio.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D008627:Mercuric Chloride; D008628:Mercury / Q000009:adverse effects*; D008767:Methylmercury Compounds / Q000009:adverse effects*; D010662:Phenylmercuric Acetate / Q000009:adverse effects*; D010663:Phenylmercury Compounds / Q000009:adverse effects*; D013552:Swine; D013917:Thrombin / Q000494:pharmacology
D000227:Adenine Nucleotides; D008767:Methylmercury Compounds; D010663:Phenylmercury Compounds; D008627:Mercuric Chloride; D013917:Thrombin; D008628:Mercury; D010662:Phenylmercuric Acetate; C004925:methylmercuric chloride