Phenytoin effect on the proliferation of rat oral epithelium is mediated by a hormonal mechanism.
Systemic pretreatment of male rats with phenytoin (PHT) (30 mg/100 g body weight) significantly (P less than 0.001) increased mitotic frequency, shortened mitotic duration and renewal time in the basal cells of the oral epithelium. This effect of PHT was abolished by simultaneous s.c. injection of cyproterone acetate (CyA) (50 micrograms/100 g body weight) or by castration. CyA treatment of intact rats or castration further decreased mitotic frequency, prolonged mitotic duration and turnover time in the oral epithelium. The effect of castration was reversed by the simultaneous s.c. injection of testosterone propionate (Tp) (50 micrograms/100 g body weight). These results suggest that PHT effect on epithelial proliferation is mediated by a hormonal mechanism.
D000818:Animals; D002369:Castration; D002610:Cheek; D003534:Cyproterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017373:Cyproterone Acetate; D004847:Epithelial Cells; D005881:Gingiva; D008297:Male; D008938:Mitosis / Q000187:drug effects; D009061:Mouth Mucosa / Q000166:cytology*; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology / Q000502:physiology*
D013739:Testosterone; D017373:Cyproterone Acetate; D010672:Phenytoin; D003534:Cyproterone