Aortic perfusion pressure and protein synthesis.
The effect of increased pressure load on cardiac protein synthesis has been studied in Langendorff preparations and working hearts supplied glucose as substrate. During the second hour of perfusion, elevation of perfusion pressure from 60 to 120 mmHg in Langendorff preparations accelerated protein synthesis by approximately 40% while induction of cardiac work and development of a systolic pressure of 145 mmHg increased synthesis by 22%, as compared to a Langendorff preparation perfused at 60 mmHg. In Langendorff preparations, increased perfusion pressure still accelerated protein synthesis when a drain was placed in the ventricle and intraventricular pressure development was prevented or when the heart was arrested with tetrodotoxin and the ventricle drained. These results suggest that the enhancement of protein synthesis with a pressure load may be induced by passive stretch of the cardiac muscle cell secondary to increased perfusion pressure.
D000818:Animals; D001011:Aorta / Q000502:physiology*; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010477:Perfusion; D011312:Pressure; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin