Monoclonal antibody-defined peripheral blood T lymphocyte subpopulations in patients with mycosis fungoides.
A panel of monoclonal antibodies has been used to identify peripheral blood lymphocyte subpopulations in 13 patients with mycosis fungoides and in 13 normal subjects. An increase in the T6+ population and a decrease in the T8+ population were noticed in our patients. Their T4/T8 ratio was considerably augmented. In 4 patients reevaluated after treatment, marked changes in the relative proportions of T lymphocyte subsets had occurred. The possible pathogenetic significance of these immunological alterations is discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000276:immunology*; D011701:PUVA Therapy; D011336:Probability; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal