Laparoscopy--a stressful procedure.
The metabolic and hormonal response to laparoscopy was investigated in 22 patients, in whom nitrous oxide-oxygen anaesthesia was supplemented with either 150 micrograms fentanyl or an Althesin infusion. There were significant increases in plasma cortisol (p less than 0.05) from 303 to 458 mmol/litre and prolactin from 1869 to 3918 mU/litre (p less than 0.01) at the end of laparoscopy in both groups of patients; these were sustained during the first hour of the recovery period. The blood glucose concentration increased significantly (p less than 0.05) from 4.48 to 5.28 mmol/litre at the end of laparoscopy in the Althesin patients and remained increased 1 hour postoperatively at 5.54 mmol/litre (p less than 0.01). The blood glucose concentration increased significantly (p less than 0.05) from 4.43 to 5.36 mmol/litre in the fentanyl patients only during the recovery period. There was no significant difference between the metabolic and hormonal changes observed with the two anaesthetic techniques.
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007431:Intraoperative Complications / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D010535:Laparoscopy; D011388:Prolactin / Q000097:blood; D013312:Stress, Physiological / Q000097:blood / Q000209:etiology*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D019344:Lactic Acid; D000530:Alfaxalone Alfadolone Mixture; D011388:Prolactin; D013006:Growth Hormone; D005283:Fentanyl; D006854:Hydrocortisone