Thymectomy-induced decrease in T gamma cells and OKT8+ cells in multiple sclerosis.
Studies were performed on lymphocytes from patients with multiple sclerosis before and after thymectomy (group I) and before and after thymectomy and azathioprine therapy (group II), and from matched control patients with multiple sclerosis, control patients with other neurological diseases, and healthy control subjects. Following treatment the percentage of T gamma cells in both group I and group II patients decreased from above the mean normal control levels to below this level; OKT8+ cell numbers in group I became lower than in any of the control groups; the percentage of concanavalin A-induced suppressor activity, which was initially normal, fell in group II and suggestively but not significantly in group I; and total blood lymphocytes in group I decreased from normal to below control levels. Other tests showed no significant changes with therapy. No significant difference in changes in clinical status were observed after one year in the treated patients compared with matched controls.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001379:Azathioprine / Q000494:pharmacology; D001402:B-Lymphocytes / Q000032:analysis / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000032:analysis* / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D013934:Thymectomy
D000911:Antibodies, Monoclonal; D001379:Azathioprine