[The effect of lysine acetylsalicylate on hemorrheological changes induced through ischemic exertion in patients with vascular disease].
This study has been performed to evaluate the in vivo effect of acetylsalicylic acid (ASA) i.v. infusion at two different dosages: 500 and 2,000 mg on the main hemorheological parameters (blood viscosity and filtrability, hematocrit) and on beta-thromboglobulin (a platelet-specific protein) in patients with peripheral obliterative arterial disease, before and after an ischemic exercise. The results obtained before and 3 and 24 h after the drug administration induced us to think that platelet-specific substances released during the ischemic exercise can affect the hemorheological parameters and that ASA may be able to interfere with these reactions by inhibiting the platelet release.
D000328:Adult; D000368:Aged; D000700:Analgesics; D001157:Arterial Occlusive Diseases / Q000097:blood*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001809:Blood Viscosity / Q000187:drug effects*; D004912:Erythrocytes / Q000502:physiology; D005260:Female; D006400:Hematocrit; D006801:Humans; D007383:Intermittent Claudication / Q000188:drug therapy*; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D013997:Time Factors; D014462:Ultrafiltration; D001620:beta-Thromboglobulin / Q000032:analysis
D000700:Analgesics; D001620:beta-Thromboglobulin; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Azione dell'acetilsalicilato di lisina sulle alterazioni emoreologiche indotte dallo sforzo ischemico in pazienti vasculopatici.