title: Ultrastructure of feline mammary hypertrophy.
abstract: The ultrastructure of feline mammary hypertrophy was studied in a five-month-old female which had aborted recently, a ten-year-old female which was one month postestrus, and a four-year-old progestin-treated neutered male. Morphologic comparisons were made to normal mammary tissue from a one-year-old female cat. Hypertrophied mammary tissue had the same cell types and spatial relationships as did the normal gland. Major differences included a more highly developed duct system composed of metabolically active cells which often were arranged in multiple cell layers, and periductular stroma with increased fibroblasts and vascularization. Hypertrophied epithelial cells were characterized generally by smooth-contoured nuclear membranes, more evenly dispersed heterochromatin, prominent nucleoli, increased polyribosomes, and elongated mitochondria. Secretory activity was developed significantly only in the cat that had aborted recently. Modifications in myoepithelial cells included: more evenly dispersed nuclear heterochromatin, thicker bundles of cytoplasmic filaments, more straight plasma membranes along the basal lamina, and elongated hemidesmosomes. Multilayering of the basal lamina was accentuated. Stromal fibroblasts had nuclear heterochromatin distributed similarly to that of epithelial and myoepithelial cells, and increased rough endoplasmic reticulum. Myoepithelial cells did not contribute to the increased stromal cellularity. No significant ultrastructural differences were noted between mammary hypertrophy in young, old, and progestin-treated cats.
mesh_terms: D000034:Abortion, Veterinary / Q000473:pathology; D000818:Animals; D001940:Breast / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000648:ultrastructure; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology; D006801:Humans; D006984:Hypertrophy / Q000473:pathology / Q000662:veterinary; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure*; D008525:Medroxyprogesterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D011247:Pregnancy
chemical_list: D007166:Immunosuppressive Agents; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone