title: [Medico-genetic study of the population of Turkmenia. IV. The population geography of hemoglobinopathies].
abstract: Large-scale screening for hereditary haemoglobinopathies in five districts and among main Turkmen tribes was carried out. The frequencies of ABO and HP pheno- and genotypes were determined in the same populations. The different kinds of haemoglobinopathies genes were discovered (beta +, beta 0-thalassemia, alpha beta-thalassemia, alpha-thalassemia, HPFH, haemoglobins D and E). The geographic and ethnic differentiation of Turkmen population for beta-thalassemia géne was discovered. The FST values were found to be the same for ABO, Hp and beta-thal gene systems. The role of genetic drift in differentiation of Turkmen population is discussed.
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D000293:Adolescent; D000328:Adult; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005828:Genetics, Population; D006453:Hemoglobinopathies / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D013789:Thalassemia / Q000235:genetics; D014423:Turkmenistan
chemical_list: D000017:ABO Blood-Group System
vernacular_title: Mediko-geneticheskoe izuchenie naseleniia Turkmenii. Soobshchenie IV. Populiatsionnaia geografiia gemoglobinopatiĭ.