title: Platelet MAO, personality and response to lithium prophylaxis.
abstract: Patients with bipolar affective disorder and who were maintained on long lithium prophylaxis were evaluated retrospectively regarding response to lithium. Good responders to lithium prophylaxis were compared to non-responders and to normal controls on platelet MAO activity, and on psychological variables (Eysenck's extraversion, neuroticism, psychoticism and lie scale; Foulds' extrapunitiveness, intropunitiveness and dominance). Lithium responders, non-responders and normal controls had similar platelet MAO activity. There was a tendency for higher plasma lithium levels to be associated with higher platelet MAO activity in male patients but not in females. Lithium non-responders exhibited significant correlations between their platelet MAO activity and their test scores on psychoticism, and extraversion. Lithium non-responders, compared to responders and normals, showed abnormal personality profiles on neuroticism, and dominance.
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000201:enzymology / Q000517:prevention & control*; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D006801:Humans; D008094:Lithium / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010551:Personality / Q000187:drug effects; D012737:Sex Factors
chemical_list: D008094:Lithium; D008995:Monoamine Oxidase