Is there a predisposition for meiotic nondisjunction that may be detected by mitotic hyperploidy?
The aneuploidy frequencies have been studied in vitro in lymphocytes from couples with recurrent abortions, from parents of a trisomic child and from control couples with at least two normal children; c-heterochromatin variants have been analysed on the same samples by length measurements. A significant increase of hyperploid cells has been observed in the lymphocytes from parents of a trisomic child and couples with recurrent abortions as well. However, no consistent correlation has been found so far between c-heterochromatin variants and an increase of aneuploidy.
D000026:Abortion, Habitual / Q000235:genetics; D000328:Adult; D000782:Aneuploidy; D004314:Down Syndrome / Q000235:genetics; D005260:Female; D006570:Heterochromatin / Q000648:ultrastructure; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008540:Meiosis; D008938:Mitosis; D011247:Pregnancy
D006570:Heterochromatin