Experimental ampicillin glomerulonephropathy.
Eighteen dogs were given repeated doses (between 4 and 19) of ampicillin (7 mg per kg intramuscularly on 3 days a week). Fifteen of the dogs developed a subclinical glomerulonephropathy characterized by mesangial hypercellularity. While only 9 of the 18 dogs showed electron-dense deposits in the mesangium, 14 dogs had glomerular deposits of IgG and 11 of these had C3 deposits also.
D000667:Ampicillin / Q000633:toxicity*; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology; D004285:Dogs; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D007105:Immune Complex Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology*
D000936:Antigen-Antibody Complex; D000667:Ampicillin