Acute and chronic vitamin C deficiency in guinea-pigs: its effect on ceruloplasmin and cytochrome P 450 and b5 levels.
Serum and liver ceruloplasmin levels rose markedly in guinea pigs with acute scurvy and with chronic latent scurvy. Their increase in the former condition can be attributed to the general stress reaction, but the increase in ceruloplasmin levels in concentration may have a stimulant effect on the ceruloplasmin, when the oxidation of Fe2+ to Fe3+ is potentiated, may obstruct the binding of iron to protoporphyrin and prevent formation of the haeme of cytochrome P 450 and b5.
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D001206:Ascorbic Acid Deficiency / Q000097:blood / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003573:Cytochrome b Group / Q000378:metabolism*; D015786:Cytochromes b5; D006168:Guinea Pigs; D007501:Iron / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male
D003573:Cytochrome b Group; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D007501:Iron; D002570:Ceruloplasmin; D001205:Ascorbic Acid