Theoretical interrelationships among immunologic and hematologic sequelae of thermal injury.
A hypothesis of possible interrelationships among immunologic and hematologic sequelae of thermal injury is presented. It is postulated that there are definable pathways involving series of abnormalities with multiple interconnections among these pathways. The initiating step of each pathway should be amenable to blockade. Such blockade would theoretically circumvent the occurrence of the abnormalities or lessen their severity and thereby preserve host resistance.
D000818:Animals; D001798:Blood Proteins; D002056:Burns / Q000097:blood / Q000276:immunology*; D003167:Complement Activation; D005122:Exudates and Transudates; D005353:Fibronectins / Q000032:analysis; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D009895:Opsonin Proteins / Q000276:immunology; D010587:Phagocytosis; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013931:Thromboxanes / Q000096:biosynthesis
D001798:Blood Proteins; D005353:Fibronectins; D009895:Opsonin Proteins; D011453:Prostaglandins; D013931:Thromboxanes