The restoration of suppressed T cell activities induced by 7,12-dimethylbenz[a]anthracene with an anti-tumor immunomodulator, BCG-cell wall skeleton.
The restoring effect of Bacille de Calmette et Guérin (BCG)-cell wall skeleton (CWS) on the suppressed T cell reactivities in mice treated with 7,12-dimethylbenz[a]anthracene (DMBA) was studied using a system involving the induction of hapten-reactive cytotoxic T cells and mixed lymphocyte reaction in vitro. When the mice were treated with DMBA, the reactivity of lymphoid cells to generate cytotoxic T cells and proliferative T cell responses against allogeneic spleen cells was markedly suppressed. When BCG-CWS was administered to mice by intravenous injection before and after the treatment with DMBA, these depressed T cell functions reverted completely to the normal level. However, the restoration of the immune functions by BCG-CWS varied depending on the strain of mice. Namely, the reactivity of C57BL/6 mice was restored by BCG-CWS, whereas that of C3H/He mice was not. This strain difference correlates very well with the strain difference in effectiveness of the prevention of the DMBA-induced tumorigenesis by BCG-CWS. The possible relation between the restoration of T cell reactivities by BCG-CWS and prevention of tumorigenesis by BCG-CWS is discussed in the context of the role of host immune surveillance in the regulation of tumor development.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000276:Adjuvants, Immunologic; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D002473:Cell Wall / Q000276:immunology; D006241:Haptens / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009163:Mycobacterium bovis / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000276:Adjuvants, Immunologic; D001551:Benz(a)Anthracenes; D006241:Haptens; D015127:9,10-Dimethyl-1,2-benzanthracene