Electrolytically labeled [99mTc]MDP: chromatographic pattern, stability and biodistribution in rats.
The labeling of methylene diphosphonate with 99mTc is possible after reduction of pertechnetate by means of controlled potential electrolysis. This results in a [99mTc]MDP complex which differs slightly from 99mTc(Sn)-MDP in paper and gel chromatography. The scintigraphic images of both preparations are comparable in quality. Biodistribution in rats shows a higher bone uptake for the 99mTc(Sn)-MDP complex, whereas [99mTc]MDP shows a higher uptake in the gastric wall.
D000818:Animals; D002850:Chromatography, Gel; D004164:Diphosphonates / Q000032:analysis / Q000378:metabolism; D004355:Drug Stability; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000032:analysis / Q000378:metabolism; D013669:Technetium Tc 99m Medronate; D014018:Tissue Distribution
D004164:Diphosphonates; D013667:Technetium; D013669:Technetium Tc 99m Medronate