title: Growth factors in Hodgkin's disease.
abstract: Tumor nodules from spleens removed at staging laparotomy for nodular sclerosing Hodgkin's disease were grown as fragment cultures in vitro. These cultures could be maintained in vitro for up to 2 months and consisted of 90% large, adherent multinuclear and mononuclear cells. Immunologic markers and enzyme histochemistry suggested that the cultured cells belonged to the monocyte/macrophage lineage. Supernatants from these cell cultures were then assayed for the monokine Interleukin I and for fibroblast stimulatory factors, which were both present. These results are discussed in considering Hodgkin's disease as a neoplasm of the monocyte/macrophage lineage, capable of producing functionally active mediators that may account for the histopathologic appearance observed.
mesh_terms: D002478:Cells, Cultured; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000378:metabolism*; D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007375:Interleukin-1; D010455:Peptides / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D013154:Spleen / Q000378:metabolism
chemical_list: D006133:Growth Substances; D007375:Interleukin-1; D010455:Peptides; D011506:Proteins; D005346:Fibroblast Growth Factors