[Pharmacokinetic studies of piperacillin after 4 g or 8 g intravenous injection in human healthy volunteers].
The pharmacokinetics of piperacillin (PIPC) after intravenous injection of 4 g and 8 g was studied on healthy volunteers, and the following results were obtained. 1. Serum concentrations of PIPC were measured, and simulation curves were obtained by using 2-compartment model. PIPC has been found to produce higher serum level soon after intravenous administration and it was rapidly eliminated. 2. In the view of pharmacokinetic parameter and peripheral compartment level of PIPC, it was estimated that distribution of PIPC of various tissues was prompt after administration. 3. PIPC was excreted rapidly, and approximately 100% excretion was observed up to 8 hours after instillation of 8 g PIPC for 2 hours. No accumulation of PIPC was noted.
D000328:Adult; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage / Q000378:metabolism*; D010878:Piperacillin
D010406:Penicillins; D010878:Piperacillin