[Effect of guanyl nucleotides and hyperbaric oxygenation on the adenylate cyclase activity of the heart in rabbits with myocardial hypertrophy].
The authors studied the role of guanyl nucleotides and hyperbaric oxygenation (HBO) in desensitization and resensitization of adenylate cyclase of the heart during hypertrophy which was induced by aorta stenosing. The basal activity of the enzyme and the rate of its activation with adrenaline and guanyl nucleotides were discovered to be reduced. In the presence of guanyl nucleotides, HBO gave rise to the recovery of enzyme sensitivity to the hormone. The data obtained indicate that during myocardial hypertrophy, guanyl nucleotides participate both in densensitization of adenylate cyclase to hormonal exposure and in the enzyme resensitization during HBO therapy.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D006332:Cardiomegaly / Q000201:enzymology / Q000628:therapy*; D004789:Enzyme Activation / Q000187:drug effects; D006150:Guanine Nucleotides / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006931:Hyperbaric Oxygenation; D009206:Myocardium / Q000201:enzymology*; D011817:Rabbits
D006150:Guanine Nucleotides; D000262:Adenylyl Cyclases
Vliianie guanilovykh nukleotidov i giperbaricheskoĭ oksigenatsii na aktivnost' adenilattsiklazy serdtsa krolikov pri gipertrofii miokarda.