Effect of various sulfur compounds on the transport system enzymes in human erythrocyte membranes.
We investigated the action of radioprotective agents: sodium S-(4-ethylphenylcarbonylmethylene)-thiosulfuric acid (SEPT), 2-(4-chlorophenyl)-thiazolidine (CPT) and dimethylsulfoxide (DMSO), on Na+/K+ATPase and Mg2+ATPase activity. SEPT inactivated more strongly Mg2+ATPase than Na+/K+ATPase, CPT dissolved in DMSO inhibited the activity of Mg2+ATPase, but did not affect that of Na+/K+ATPase. DMSO alone increased the activity of Mg2+ATPase and inhibited that of Na+/K+ATPase. Thus DMSO and CPT seem to act antagonistically on the activity of ATPases. The results indicate that radioprotectants strongly affect ATPases participating in membrane transport.
D000098:Acetophenones / Q000494:pharmacology; D000110:Acetylcholinesterase / Q000097:blood; D000251:Adenosine Triphosphatases / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D013455:Sulfur / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology; D053778:Thiazolidines
D000098:Acetophenones; D013844:Thiazoles; D053778:Thiazolidines; D013455:Sulfur; C036665:2-(4-chlorophenyl)thiazolidine; C032245:S(4-ethylphenylcarbonylmethylene)-thiosulfuric acid; D000110:Acetylcholinesterase; D000251:Adenosine Triphosphatases; D004121:Dimethyl Sulfoxide