Regulation of glucose-6-phosphate dehydrogenase activity during caloric restriction in human adipose tissue.
Glucose-6-phosphate dehydrogenase activity was significantly lower in adipose tissue of human subjects after 7 days of severe caloric restriction on low-carbohydrate diets and had returned to normal values 4 days after the subjects resumed normal diets. Three other enzyme activities (malate-NADP dehydrogenase, oxaloacetate decarboxylating; ATP-citrate lyase and 6-phosphofructokinase) were not significantly affected by these dietary changes. These results are consistent with separate control of glucose-6-phosphate dehydrogenase activity versus other 'lipogenic' enzyme activities in human adipose tissue.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000273:Adipose Tissue / Q000201:enzymology*; D000328:Adult; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D002149:Energy Intake; D005260:Female; D005502:Food; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006801:Humans; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D010732:Phosphofructokinase-1 / Q000378:metabolism
D004040:Dietary Carbohydrates; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase; D010732:Phosphofructokinase-1