The domain of platelet glycoprotein I as recognized by various antibodies, both monoclonal and polyspecific.
Platelet membrane glycoprotein Ib plays a major role in the binding of factor VIII/von Willebrand factor to allow platelet adhesion to subendothelium. We have used polyspecific and monoclonal antibodies to glycoprotein Ib and have demonstrated that both antibodies were directed to glycoprotein Is, a soluble fragment of glycoprotein Ib. By showing an inhibition of the binding of factor VIII/von Willebrand factor to control platelets in presence of the antibodies, it can be concluded that glycoprotein Is is involved in these binding sites.
D000911:Antibodies, Monoclonal / Q000276:immunology; D001665:Binding Sites; D001778:Blood Coagulation Disorders / Q000097:blood; D001792:Blood Platelets / Q000648:ultrastructure*; D005169:Factor VIII / Q000378:metabolism; D006023:Glycoproteins / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology / Q000502:physiology*; D010973:Platelet Adhesiveness; D010980:Platelet Membrane Glycoproteins; D013920:Thrombocythemia, Essential / Q000097:blood; D013921:Thrombocytopenia / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
D000911:Antibodies, Monoclonal; D006023:Glycoproteins; D007074:Immunoglobulin G; D008565:Membrane Proteins; D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor; D005169:Factor VIII