title: A double blind study of imipramine versus zimelidine in treatment of obsessive compulsive neurosis.
abstract: Six patients suffering from obsessive compulsive neurosis were randomly allocated into two groups of three patients each and commenced on either imipramine, a noradrenaline re-uptake inhibitor, or zimelidine, a serotonin re-uptake inhibitor. After 4 weeks, the group on zimelidine showed significant reduction of obsessional symptoms as compared to the other group. The response was rapid and sustained over a period of two months.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D011897:Random Allocation; D015031:Zimeldine / Q000627:therapeutic use*
chemical_list: D015031:Zimeldine; D007099:Imipramine