Radiation-resistant IgE-secreting cells in the mouse: susceptibility to suppressor T cells.
X-irradiation (800 or 1,000 R) of Balb/c mice displaying 'persistent' high-titer anti-ovalbumin IgE responses resulted in only minor decreases in antibody titres measured 40 days later, indicating that the bulk of IgE production could be ascribed to long-lived radiation-resistant (and thus non-dividing) plasma cells. IgE-specific suppressor T cells from ovalbumin-tolerant mice did not affect ongoing persistent IgE synthesis by these plasma cells, but prevented their emergence in ovalbumin-immunized mice and in those adoptively immunized with splenocytes from animals displaying persistent IgE responses.
D000818:Animals; D000921:Antibody-Producing Cells / Q000528:radiation effects*; D004306:Dose-Response Relationship, Immunologic; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D011828:Radiation Chimera; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007073:Immunoglobulin E; D010047:Ovalbumin