Asynchronous metastasizing renal cell carcinoma associated with progressive immune complex glomerulonephritis and proteinuria.
A case of asynchronous renal carcinoma with a 15-year course is described. Right nephrectomy and left heminephrectomy were performed. Solitary metastases to pancreas and striated muscle were treated with total pancreatectomy and local excision, respectively. The patient died of renal failure due to progressive immune complex glomerulonephritis, which was documented histologically as well as by clinical observations of intensifying excretion of urinary protein with decreasing selectivity. The glomerular lesion is suggested to have been caused by deposition of tumour-related immune complexes arising from an immune response by the host to his tumour.
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary*; D005921:Glomerulonephritis / Q000473:pathology*; D006801:Humans; D007105:Immune Complex Diseases / Q000473:pathology*; D007074:Immunoglobulin G / Q000378:metabolism; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D010190:Pancreatic Neoplasms / Q000556:secondary*; D011507:Proteinuria / Q000473:pathology*
D007074:Immunoglobulin G