[Effect of nicergoline and dihydroergotamine, injected into the cerebral ventricles, on arterial pressure in the cat].
Nicergoline, injected into the cerebral ventricles of anaesthetized cats induced a moderate, but longlasting and dose-dependent fall of the blood pressure. Dihydroergotamine, in moderate doses, had no effect on the arterial blood pressure. Toxic doses of nicergoline and dihydroergotamine provoked a pronounced fall of the arterial blood pressure and inhibition of the respiration. Bradycardia only appeared after toxic doses of dihydroergotamine. It is concluded that the hypotensive effect of nicergoline is at least in part central in origin.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004087:Dihydroergotamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009530:Nicergoline / Q000008:administration & dosage / Q000494:pharmacology*
D004873:Ergolines; D004087:Dihydroergotamine; D009530:Nicergoline
Action de la nïcergoline et de la dihydroergotamine, injectées dans les ventricules cérébraux, sur la pression artérielle du Chat.