Successful transplantation with a positive T and B cell crossmatch due to autoreactive antibodies.
A total of 16 cadaver donor renal allografts have been performed in the presence of a positive T and B cell crossmatch due to autoantibodies. Fourteen of these patients were considered to be highly-sensitized, in that they had pregraft antibodies reacting with more than 85% of the lymphocyte panel. Ten of the 16 grafts are still functioning with follow-up times of between 3 and 66 months. Within the same time period three living related donor transplants were also performed with a positive T and B cell crossmatch due to autoantibodies. Two were from HLA-identical siblings and the other from his father. All three patients had pregraft antibodies reacting with 100% of the lymphocyte panel. All grafts are functioning normally between 9 and 48 months after transplantation. Autoreactive T and B cell antibodies are not damaging to renal allografts and recognition of these antibodies allows a significant number of patients to be successfully transplanted (with a positive crossmatch).
D000937:Antigen-Antibody Reactions; D000961:Antilymphocyte Serum / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation; D007945:Leukemia, Lymphoid / Q000150:complications / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D014019:Tissue Donors
D000961:Antilymphocyte Serum; D001323:Autoantibodies; D006680:HLA Antigens