[Measurement of sulfoconjugates of 5-androsten-3 beta, 17 beta-diol in idiopathic hirsute virilism].
The sulphoconjugates of delta 5-C19O2 steroids were determined in 32 women with idiopathic hirsutism (IH). The plasma and urinary levels of 5-androsten-3 beta, 17 beta-diol (delta 5, 3 beta-diol) were 82 +/- 24 ng/ml and 169 +/- 170 micrograms/24 h respectively for the monosulphate ester and 193 +/- 101 ng/ml and 180 +/- 108 micrograms/24 h for the disulphate ester. These levels are statistically higher (p less than 0,001) as compared with the levels observed in women without IH (30 +/- 20 ng/ml and 23 +/- 13 micrograms/24 h for the monosulphate, 78 +/- 40 ng/ml and 48,0 +/- 23,7 micrograms/24 h for the disulphate). There is a correlation between the urinary levels of the monosulphate of delta 5, 3 beta-diol (y) and of the dehydroepiandrosterone sulphate (S-DHA) (x) : y (microgram/24 h) = 0,124x + 16,8; r = 0,93 (p less than 0,01) and n = 32. The plasma levels of S-DHA ranged form 1,250 ng/ml to 7,000 ng/ml in the abnormal population and from 1,000 ng/ml to 2,400 ng/ml in the normal population. A concomitant determination of plasma free androgens showed that 60 % of the dehydroepiandrosterone values were above the upper limits of normal values. Conversely, the testosterone and androstenedione levels were only higher in 20 % and 27 % of cases respectively. These results suggest that the possible importance of the sulphoconjugates of delta 5-C19O2 steroids in the IH pathogeny should not be overlooked.
D000328:Adult; D015114:Androstenediol / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000734:Androstenediols / Q000378:metabolism*; D000735:Androstenedione / Q000097:blood; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D006628:Hirsutism / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D011863:Radioimmunoassay; D013739:Testosterone / Q000097:blood
D000734:Androstenediols; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; C033537:5-androstene-3 beta,17 beta-diol sulfate; D015114:Androstenediol
Mesure des sulfoconjugués de 5-androstène-3 beta, 17 beta-diol dans le virilisme pilaire idiopathique.