title: Response of generalized granuloma annulare to high-dose niacinamide.
abstract: A patient with generalized granuloma annulare experienced resolution of her lesions after six months of treatment with 1,500 mg/day of niacinamide. Niacinamide seems to be a reasonably safe drug that, even at relatively high doses, is associated with a low incidence of side effects. The participation of a delayed hypersensitivity reaction in the pathogenesis of granuloma annulare and possible mechanisms involving niacinamide in this type of reaction are discussed.
mesh_terms: D005260:Female; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000150:complications; D008875:Middle Aged; D009536:Niacinamide / Q000008:administration & dosage*; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D009536:Niacinamide