[Migration and adhesiveness of human and rabbit blood leukocytes under the influence of metabolic blocking agents and hirudin].
The adherence inhibition by lymphokines and by hirudin do not correspond to another, in the first case it is connected with a migration inhibition, the second with a slight increase of migration. There are significant differences between granulocytes and lymphocytes in relation to adherence and migration caused by the influence of inhibitors on the metabolism. The possible reason is the different basic metabolism of these two kinds of cells. But the two inhibitors of glycolysis NaF and monoiodoacetic acid acts in a similar way as inhibitors on the migration of granulocytes and lymphocytes. The negative influence of hirudin on the adherence of lymphocytes and the promoting effect in the migration experiments account for participation of components of the coagulation system in both cell functions. Possibly mechanisms of the attachment are directly concerned. From the wide conformity of the experiments with metabolism inhibitors and reactions of cell-mediated immunity under influence of lymphokines we like to conclude that lymphokine-caused migration inhibition and adherence inhibition were produced by an impairement of metabolism.
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D001386:Azides / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects*; D002464:Cell Migration Inhibition; D003847:Deoxyglucose / Q000276:immunology / Q000494:pharmacology; D006019:Glycolysis / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D006629:Hirudins / Q000494:pharmacology*; D006801:Humans; D007461:Iodoacetates / Q000276:immunology / Q000494:pharmacology; D019807:Iodoacetic Acid; D007962:Leukocytes / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011190:Potassium Cyanide / Q000494:pharmacology; D011817:Rabbits; D019810:Sodium Azide; D012969:Sodium Fluoride / Q000276:immunology / Q000494:pharmacology
D000963:Antimetabolites; D001386:Azides; D006629:Hirudins; D007461:Iodoacetates; D012969:Sodium Fluoride; D019810:Sodium Azide; D003847:Deoxyglucose; D011190:Potassium Cyanide; D019807:Iodoacetic Acid
Untersuchungen über Migration und Haftung von Blutleukozyten des Menschen und Kaninchens bei Einwirkung von Stoffwechsel-blockern und von Hirudin.