[Study of the effect of 2 inhibitors of nucleotide synthesis, aminopterin and fluorodeoxyuridine, on wild type strains and vestigial mutants in Drosophila melanogaster].
Two inhibitors of nucleotide metabolism, aminopterin and FUdR, were tested on a wild type strain, on two mutant strains: vg and vgnp, and on a vg strain with the wild type genetic background. Without inhibitors, a lengthening of the developing time was observed for the mutant strains compared to the wild type. With aminopterin, larval mortality and lengthening of developing time are significantly higher in the wild type than in the mutant strains. Mutant strains seemed to be resistant to low concentrations of FUdR. The hypothesis of a perturbed pyrimidine metabolism in the mutants seems to be confirmed.
D000630:Aminopterin / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D005467:Floxuridine / Q000494:pharmacology*; D008297:Male; D009154:Mutation; D009711:Nucleotides / Q000037:antagonists & inhibitors*; D012741:Sexual Maturation / Q000187:drug effects
D009711:Nucleotides; D005467:Floxuridine; D000630:Aminopterin
Etude de l'effet de deux inhibiteurs de la synthèse des nucléotides l'aminoptérine et la fluorodésoxyuridine sur des souches sauvage et mutantes vestigial chez Drosophila melanogaster.