Lipomodulin: a possible mediator of the action of glucocorticoids.
Lipomodulin, a protein with a MW of 40,000, is induced in many cells by glucocorticoids. This protein can mimic a variety of biological activities of glucocorticoids such as anti-inflammation, immunosuppression, and promotion of cellular differentiation. Since anti-lipomodulin antibody can block these effects of both glucocorticoids and lipomodulin, it is quite possible that lipomodulin is a mediator of glucocorticoids.
D000818:Animals; D017302:Annexins; D002135:Calcium-Binding Proteins; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D006023:Glycoproteins; D009239:N-Formylmethionine / Q000031:analogs & derivatives / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D009842:Oligopeptides / Q000494:pharmacology; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D010743:Phospholipids / Q000378:metabolism; D010766:Phosphorylation; D014176:Protein Biosynthesis; D011506:Proteins / Q000302:isolation & purification / Q000502:physiology*; D011817:Rabbits
D017302:Annexins; D002135:Calcium-Binding Proteins; D005938:Glucocorticoids; D006023:Glycoproteins; D009842:Oligopeptides; D010743:Phospholipids; D011506:Proteins; C030958:lipomodulin; D009239:N-Formylmethionine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D010740:Phospholipases; D010741:Phospholipases A