Study of helper and suppressor T-cells in cystic fibrosis.
The ratio between inducer and cytotoxic/suppressor subset T-cells was studied in 11 cystic fibrosis patients and 11 non-cystic fibrosis controls. No statistically significant difference was found between the two groups. It is suggested that the major immune deficiency in some patients suffering from cystic fibrosis is a state of tolerance to the same bacterial antigens such as Pseudomonas aeruginosa. Inhibitory factors are present in the serum of the most affected patients.
D000293:Adolescent; D000942:Antigens, Bacterial / Q000276:immunology; D003550:Cystic Fibrosis / Q000276:immunology*; D005260:Female; D006801:Humans; D007109:Immunity; D008213:Lymphocyte Activation; D008297:Male; D011550:Pseudomonas aeruginosa / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000942:Antigens, Bacterial