title: Hospital outbreak of hepatitis A: risk factors for spread.
abstract: A 34-month-old girl with Down's syndrome from the Marshall Islands was hospitalized in September, 1981, at Tripler Army Medical Center for evaluation of a heart murmur and definitive repair of an imperforate anus for which she had had a colostomy since birth. She became jaundiced and had serologic evidence of hepatitis A infection. Over the next month eight hospital personnel (four nurses, three nursing assistants and one physician) who had had direct contact with the patient became ill with hepatitis A. Our patient, like the index cases in five previous reports of nosocomial hepatitis A outbreaks, was incontinent of feces. In addition she was hospitalized during the incubation period before clinical illness when virus fecal excretion is likely to be maximal. Patients in the prodromal stage of hepatitis A infection who are hospitalized pose a significant risk to exposed hospital staff. This risk is enhanced if there are additional factors present which promote spread of disease by the fecal-oral route such as infancy, mental retardation, diarrhea and fecal incontinence.
mesh_terms: D000328:Adult; D002675:Child, Preschool; D003428:Cross Infection / Q000635:transmission*; D004314:Down Syndrome / Q000150:complications; D005242:Fecal Incontinence / Q000150:complications; D005260:Female; D006506:Hepatitis A / Q000150:complications / Q000635:transmission*; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000209:etiology*; D010564:Personnel, Hospital; D012306:Risk