title: [Nature of the cells regulating the production of a migration inhibition factor in C57BL/6 strain mice with low response to Candida albicans antigen].
abstract: The authors studied cell regulation of macrophage migration inhibition factor (MIF) in response to Candida albicans antigen in C57BL/6 mice. It was revealed that low MIF production in response to this antigen is determined by the existence of specific suppressors which are inhibited by cyclophosphamide. The differences between the mouse lines are accounted for by different activity of suppressor cells of the thymic origin, which is confirmed by the treatment with anti-Thy1-serum and by bone marrow cell transfer.
mesh_terms: D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D007114:Immunization; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D008808:Mice, Inbred CBA; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
chemical_list: D000946:Antigens, Fungal; D008263:Macrophage Migration-Inhibitory Factors; D003520:Cyclophosphamide
vernacular_title: Izuchenie prirody kletok-reguliatorov vyrabotki faktora, ugneta-iushchego migratsiiu, u mysheĭ linii C57BL/6, nizkootvechaiushcheĭ na antigen Candida albicans.