The effect of a proline-rich polypeptide (PRP) on the humoral immune response. II. PRP induces differentiation of helper cells from glass-nonadherent thymocytes (NAT) and suppressor cells from glass-adherent thymocytes (GAT).
Normal mice given thymocyte subpopulations preincubated with a proline-rich polypeptide (PRP) and immunized with SRBC show enhanced or suppressed humoral immune response measured by the number of plaque-forming cells (PFC). PRP induces differentiation of cells exhibiting helper or suppressive function from NAT and GAT respectively. Moreover, it was demonstrated that PRP-induced helper cells lost their activity after treatment with anti-Lyt 1,1 and the PRP-induced suppressor cells after treatment with anti-Lyt 2,1 monoclonal antibodies.
D000818:Animals; D000911:Antibodies, Monoclonal; D000917:Antibody Formation / Q000187:drug effects*; D002448:Cell Adhesion; D002454:Cell Differentiation; D002478:Cells, Cultured; D005260:Female; D051379:Mice; D008811:Mice, Inbred DBA; D010455:Peptides / Q000494:pharmacology*; D055232:Proline-Rich Protein Domains; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000187:drug effects / Q000276:immunology
D000911:Antibodies, Monoclonal; D010455:Peptides