[Enhancement of the activity of hepatitis B virus vaccine by association with murabutide].
Murabutide (N-acetyl-muramyl-L-alanyl-D-glutamine-alpha-butylester), an MDP analogue, is a potential adjuvant for Human immunization. High levels of specific antibodies were obtained in Mouse and Guinea-Pig following administration with murabutide of low dosages of anti-hepatitis B viral vaccine containing the surface antigen (HBs). The effect of murabutide was enhanced without increasing the level of specific IgE by association with suboptimal dosages of aluminium hydroxide.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines; D007073:Immunoglobulin E / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D014765:Viral Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014765:Viral Vaccines; D007073:Immunoglobulin E; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C033575:murabutide
Renforcement de l'activité d'un vaccin contre l'hépatite virale de type B par association avec le murabutide.