The effect of interaction between subsequent doses of MeHgCl or HgCl2 on the biliary excretion of mercury from each individual dose.
The biliary excretion and organ distribution of mercury was investigated in male rats which received mercuric chloride (HgCl2) (0.65 mg/kg Hg2+) or methylmercury chloride (MeHgCl) (2 mg/kg Hg) i.p. and 48 h later the same compound i.v. Mercury was labelled with 203Hg either in the first or second injection. In controls saline was substituted for unlabelled mercury. In one experiment rats pretreated with HgCl2 were given Me203HgCl 48 h later. The biliary excretion and organ distribution of 203Hg were not influenced by the injection of cold MeHgCl given before or after Me203HgCl or by HgCl2 given 48 h after 203HgCl2. HgCl2 given 48 h before the injection of 203HgCl2 or Me203HgCl significantly decreased biliary excretion of 203Hg despite increased 203Hg levels in blood and liver.
D000818:Animals; D001646:Bile / Q000032:analysis*; D004347:Drug Interactions; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008627:Mercuric Chloride; D008628:Mercury / Q000378:metabolism*; D008631:Mercury Radioisotopes; D008767:Methylmercury Compounds / Q000378:metabolism*; D051381:Rats; D014018:Tissue Distribution
D008631:Mercury Radioisotopes; D008767:Methylmercury Compounds; D008627:Mercuric Chloride; D008628:Mercury; C004925:methylmercuric chloride