title: [Passage of nonsteroidal anti-inflammatory agents across the synovial membrane].
abstract: The therapeutic effectiveness of non-steroid anti-inflammatory (NSAI) drugs is partly determined by their passage across the synovial membrane. The synovium can be compared to a double barrier the permeability of which to NSAI drugs depends on the degree of inflammation of the joint and on the pharmacokinetic properties of the drugs (lipophilia, pka, protein-binding). A few hours after one single systemic dose, concentrations in the synovial fluid are higher than in serum. During chronic administration, concentrations of NSAI drugs with a short half-life vary less in synovial fluid than in serum. During steady state, free fractions of NSAI drugs with prolonged half-life may be similar in both compartments.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007592:Joint Diseases / Q000378:metabolism; D013583:Synovial Membrane / Q000378:metabolism* / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents
vernacular_title: Le passage des anti-inflammatoires non stéroïdiens à travers la synoviale.