Participation of an extracellular deaminase in amino acid utilization by Neurospora crassa.
A strain of Neurospora crassa defective in amino acid transport can utilize a variety of amino acids for growth when readily metabolizable nitrogen is limiting. Growth is accompanied by the production of an extracellular deaminase that converts the amino acid to its respective keto acid plus equimolar quantities of utilizable nitrogen in the ammonium ion form. Production of the deaminase is subject to ammonium repression. The relationship between the ability of an amino acid to trigger deaminase production and the presence of particular amino acid permease deficiencies is complex. Four classes of amino acids have been defined with respect to this relationship. The existence of multiple extracellular deaminases is discussed.
D000596:Amino Acids / Q000378:metabolism* / Q000494:pharmacology; D000619:Aminohydrolases / Q000378:metabolism*; D001667:Binding, Competitive; D003470:Culture Media; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology* / Q000254:growth & development; D010649:Phenylalanine / Q000378:metabolism; D013045:Species Specificity
D000596:Amino Acids; D003470:Culture Media; D026901:Membrane Transport Proteins; D010649:Phenylalanine; D000619:Aminohydrolases; D007930:Leucine