Streptozotocin-induced renal tumors in rats: microangiographic-histologic correlation.
A combination of histologic and barium perfusion-microangiographic methods have been employed to correlate cytologic and microangiographic characteristics of Streptozotocin-induced renal tumors in rats. Four of 11 rats developed renal tumors within six to seven months following Streptozotocin administration. A total of twelve tumors was found in these animals. The neoplasms displayed a continuum of benign and malignant cytologic characteristics and varied considerably in extent of vascularity, as seen on microangiography. One tumor appeared locally invasive beyond the confines of its pseudo-capsule. Microangiography depicted well the microvascular features of these tumors and correlated closely with the histologic findings.
D000818:Animals; D001466:Barium Sulfate; D007680:Kidney Neoplasms / Q000098:blood supply / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin
D001466:Barium Sulfate; D013311:Streptozocin