[Effect of serotoninergic substances on escape behavior in acute stress situations].
The data are provided on the effect of some serotoninergic substances on the avoidance behavior under acute stress. 5-Hydroxytryptophan, zimelidine (low doses), pyrenepyron, ciproheptadine, trazodon (high doses), produced a noticeable positive action on the behavior pattern under study. Quipazin and zimelidine (high doses) provoked an increase in the number of affective manifestations and a rise of the latent avoidance time. Regardless of an appreciable fall in the number of affective manifestations, the powerful sedative effect of m-chlorphenylpiperazine led to an increase in the latent response periods. It was shown that substances that produced a direct or mediated activation effect on the serotoninergic system had an appreciable favourable influence on the avoidance behavior, which was a consequence of a decrease in the animals' emotional excitement. Combination of serotonin-blocking properties (action on S2-autoreceptors) and dopaminergic properties brought about optimal results, provided that pyrenepyron was applied.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects*; D006801:Humans; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013315:Stress, Psychological / Q000523:psychology*; D014149:Tranquilizing Agents / Q000494:pharmacology; D014196:Trazodone / Q000494:pharmacology; D015031:Zimeldine
D000928:Antidepressive Agents; D010879:Piperazines; D010880:Piperidines; D014149:Tranquilizing Agents; D003533:Cyproheptadine; D012701:Serotonin; D015031:Zimeldine; D011814:Quipazine; D006916:5-Hydroxytryptophan; D001977:Brompheniramine; C015068:1-(3-chlorophenyl)piperazine; C034177:pirenperone; D014196:Trazodone
Vliianie serotoninergicheskikh veshchestv na povedenie izbavleniia v situatsii ostrogo stress-vozdeĭstviia.