The effects of various anti-calcific, anti-rheumatic and anti-inflammatory drugs on local (simple) calcergy induced by lead acetate in the mouse.
The diphosphonate compound ethane-hydroxy-1, 1-diphosphonate (EHDP) is an effective inhibitor of the calcification reaction induced by the subcutaneous injection of lead acetate in the mouse. Dichloromethylene diphosphonate (CL2MDP) has no such effect and prednisolone and sodium aurothiomalate are also ineffective in inhibiting the reaction. The rate of resorption of the calcified plaque is decreased by C12MDP when this is administered on an extended basis. This effect disappears after prolonged treatment so that EHDP, calcitonin and C12MDP have no effect after 7 weeks of daily treatment.
D000818:Animals; D002114:Calcinosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004002:Clodronic Acid / Q000627:therapeutic use*; D003238:Connective Tissue / Q000473:pathology; D003240:Connective Tissue Diseases / Q000188:drug therapy; D004164:Diphosphonates / Q000627:therapeutic use*; D012968:Etidronic Acid / Q000627:therapeutic use*; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use*; D007854:Lead; D008297:Male; D051379:Mice; D009942:Organometallic Compounds; D011239:Prednisolone / Q000627:therapeutic use*; D013997:Time Factors
D004164:Diphosphonates; D009942:Organometallic Compounds; D004002:Clodronic Acid; D006052:Gold Sodium Thiomalate; D007854:Lead; D011239:Prednisolone; D012968:Etidronic Acid; C008261:lead acetate