Maculopapular eruption resulting from systemic administration of 5-fluorouracil.
An unusual eruption was noted following a particularly prolonged course of intravenous 5-fluorouracil (5-FU) as treatment of metastatic breast carcinoma. This eruption differed from dermatologic reactions previously noted in response to 5-FU in that it was not confined to sun-exposed surfaces as is characteristic of the nonallergic responses to 5-FU, nor was its onset immediate and generalized, as is characteristic of the rare allergic responses to this drug.
D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006229:Hand Dermatoses / Q000139:chemically induced / Q000473:pathology; D006801:Humans
D005472:Fluorouracil