[Epithelial structural changes in the urinary tubules of the kidney of the white rat in the early period of corrosive sublimate nephrosis].
Examination of serial semithin (0.5 micron) methacrylate and paraffin (8 micron) sections of the rat kidney 6, 12, 24 and 48 hours after subcutaneous injection of sublimate in a dose of 0.6 mg/100 g bw has demonstrated that the damage to the different parts of the tubular component of nephron is heterogeneous in nature. Both complete and partial necrosis of nephrocyte cytoplasm can be seen in the proximal part of nephron. The distal parts of nephron and collective tubules are characterized by partial necrosis of the apical areas of the cytoplasm. During the period between 12 and 24 hours after sublimate injection, one can observe the onset of destructive processes together with intracellular recovery processes in partially damaged but still viable nephrocytes, which is confirmed by the enlargement of the nucleolar size. The regeneration of the tubular epithelium at the expense of cellular renewal was unmarked 24 hours after sublimate injection.
D000818:Animals; D004848:Epithelium / Q000187:drug effects / Q000503:physiopathology; D007684:Kidney Tubules / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008627:Mercuric Chloride; D008628:Mercury / Q000633:toxicity*; D009401:Nephrosis / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects; D013997:Time Factors
D008627:Mercuric Chloride; D008628:Mercury
Strukturnye izmeneniia épiteliia mochevykh kanal'tsev pochki beloĭ krysy v ranniĭ period sulemovogo nefroza.