The effect of radioimmunosuppression on the development of low-dose streptozotocin diabetes.
We investigated the effect of whole body irradiation (6.0 Gy) on the development of low-dose streptozotocin diabetes in male C57 Bl/KsJ-mice. After induction of the process of diabetes development irradiation failed to interfere with the development of hyperglycemia and did not modify the reduced pancreatic insulin content after exogenous diabetes induction.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000276:immunology*; D006400:Hematocrit; D006943:Hyperglycemia / Q000276:immunology; D007165:Immunosuppression Therapy / Q000379:methods; D007328:Insulin / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010179:Pancreas / Q000528:radiation effects; D013311:Streptozocin / Q000008:administration & dosage; D014916:Whole-Body Irradiation
D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin