[Antibacterial activity of the combination of cefoperazone piperacillin].
The effect of the combination cefoperazone plus piperacillin was tested against 131 clinical isolates of gram-positive and gram-negative bacteria by checkerboard titration and by determining the serum bactericidal activity. The interaction was synergistic against 9% of the strains in vitro and partially synergistic against 48%. In the serum bactericidal tests bactericidal titers higher than 1:8 were obtained with the combination one hour after administration. No antagonism was observed either in the in vitro tests or in tests of serum bactericidal activity.
D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology; D002438:Cefoperazone; D002511:Cephalosporins / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D010406:Penicillins / Q000494:pharmacology*; D010878:Piperacillin
D002511:Cephalosporins; D004338:Drug Combinations; D010406:Penicillins; D002438:Cefoperazone; D010878:Piperacillin
Antibakterielle Aktivität der Kombination von Cefoperazon und Piperacillin.