[Effect of clofibride on the lipolysis of perirenal adipose tissue in hyperlipemic rabbits].
In hyperlipaemic rabbits (fat supply), perirenal adipose tissue lipolysis does not vary with one in vitro clofibride dose. After a 16 days pretreatment, one in vitro clofibride dose reduces the basal lipolysis and the lipolytic action of synacthene, and increases the antilipolytic effect of insulin. The reduction of the lipolysis of adipose tissue could explain, in part, the hypolipaemic action of clofibride.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000494:pharmacology; D003366:Cosyntropin / Q000494:pharmacology; D005260:Female; D006949:Hyperlipidemias / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008066:Lipolysis / Q000187:drug effects*; D011817:Rabbits
D000960:Hypolipidemic Agents; D007328:Insulin; C007089:clofibride; D003366:Cosyntropin; D002994:Clofibrate
Actions du clofibride sur la lipolyse du tissu adipeux périrénal chez le lapin hyperlipémique.