The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties.
A 28 amino acid peptide with diuretic and natriuretic activity has been purified from rat atrial muscle. The primary structure of this atrial peptide is H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly- (sequence in text) Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-(Arg)-Tyr-OH. The biological activity of this peptide is identical to that of atrial natriuretic factor and cardionatrin I isolated from rat atria.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D009320:Atrial Natriuretic Factor; D055598:Chemical Phenomena; D002621:Chemistry; D004232:Diuretics / Q000302:isolation & purification; D006325:Heart Atria / Q000032:analysis*; D008297:Male; D009318:Natriuresis; D010455:Peptides / Q000302:isolation & purification*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D004232:Diuretics; D010455:Peptides; D009320:Atrial Natriuretic Factor