Retardation of thyroxine-induced metamorphosis by Amphenone B in toad tadpoles.
The effect of Amphenone B, an inhibitor of corticoid synthesis, on thyroxine (T4)-induced metamorphosis was studied in toad tadpoles kept in thiourea. Amphenone injections retarded T4-induced tail resorption markedly. The effect of Amphenone was nullified by aldosterone and corticosterone added to the water in which tadpoles were kept. Steroidogenic cells of adrenals in Amphenone-injected animals were enlarged markedly as compared with those in the saline-injected tadpoles or the Amphenone-injected tadpoles which were supplemented with corticoids. The results strongly suggest that endogenous corticoids act together with thyroid hormone to accelerate metamorphosis.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology; D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D002023:Bufo bufo / Q000502:physiology*; D002074:Butanones / Q000494:pharmacology*; D008675:Metamorphosis, Biological / Q000187:drug effects*; D013890:Thiourea / Q000494:pharmacology; D013974:Thyroxine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000305:Adrenal Cortex Hormones; D002074:Butanones; D000450:Aldosterone; D013890:Thiourea; D013974:Thyroxine