[Protective effect of Pseudomonas-specific immunoglobulin from the rabbit and of active immunization in experimental Pseudomonas sepsis in mice].
Using the model of an experimental Pseudomonas septicemia in mice, the protective effect of specific antipseudomonal immunoglobulin from rabbits was examined. During bacterial spreading in the bloodstream, a protective effect could be demonstrated under certain conditions. The degree of protection was equivalent to that achieved by active immunization. After bacterial colonization and replication in parenchymal organs no further therapeutic effect could be detected.
D000818:Animals; D000907:Antibodies, Bacterial; D003520:Cyclophosphamide / Q000494:pharmacology; D007108:Immune Tolerance; D007114:Immunization; D007116:Immunization, Passive; D051379:Mice; D010406:Penicillins / Q000627:therapeutic use; D010878:Piperacillin; D011552:Pseudomonas Infections / Q000276:immunology / Q000628:therapy*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits; D018805:Sepsis / Q000276:immunology / Q000628:therapy*
D000907:Antibodies, Bacterial; D010406:Penicillins; D003520:Cyclophosphamide; D010878:Piperacillin
Schutzwirkung von pseudomonas-spezifischem Hyperimmunglobulin vom Kaninchen und von aktiver Immunisierung bei experimenteller Pseudomonas-Sepsis der Maus.