[Determination of plasma 5 alpha-androstane-3 alpha, 17 beta-diol in the hirsute woman. A critical study of the biological diagnosis of hyperandrogenism].
Plasma 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol) levels were measured by radioimmunoassay after separation by column chromatography in normal and hirsute women. Mean values were 106 +/- 17 pg/ml in normal women and 182 +/- 22 pg/ml in hirsute women, the difference being significant (p less than 0.001). High plasma 3 alpha-diol levels were found in 29 out of 31 patients. Measurements of testosterone (T), delta-4 androstenedione (A) and dehydro epiandrosterone sulphate were performed simultaneously in 23 patients. The 3 alpha-diol measurements proved as useful as the other parameters to assess biochemical hyperandrogenism, but they cannot replace simultaneous T and A measurements which remain the best diagnostic criteria.
D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D015113:Androstane-3,17-diol / Q000097:blood*; D000732:Androstanols / Q000097:blood*; D000735:Androstenedione / Q000097:blood; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006628:Hirsutism / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D011863:Radioimmunoassay; D013237:Stereoisomerism; D013739:Testosterone / Q000097:blood
D000728:Androgens; D000732:Androstanols; D015113:Androstane-3,17-diol; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate
Dosage du 5 alpha-androstane-3 alpha, 17 beta-diol plasmatique chez la femme hirsute. Etude critique du diagnostic biologique de l'hyperandrogénie.