A protein inhibitor of phosphofructokinase from the mucosa of rat small intestine. A mechanism for the regulation of glycolysis that is independent of glucose.
A protein inhibitor of phosphofructokinase was detected by the chromatography on Sephadex G-100 of crude mucosal extracts prepared from the small intestine of starved rats. Addition of the protein inhibitor to extracts from fed rats increased the K0.5 of phosphofructokinase for fructose 6-phosphate to that for starved rats. The protein inhibitor provides a mechanism for the hormonal regulation of glycolysis independently of glucose supply.
D000818:Animals; D002850:Chromatography, Gel; D004791:Enzyme Inhibitors / Q000302:isolation & purification; D005260:Female; D006019:Glycolysis; D007413:Intestinal Mucosa / Q000032:analysis*; D007583:Jejunum / Q000032:analysis*; D010732:Phosphofructokinase-1 / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism
D004791:Enzyme Inhibitors; D010732:Phosphofructokinase-1