title: [Biological characteristics of spectinomycin-resistant strains of the tularemia pathogen].
abstract: Sensitivity of 2 subspecies of the tularemia causative agent to spectinomycin, an aminoglycoside antibiotic, was studied in vitro. The MIC of the antibiotic with respect to strains 503/847 and Schu was 40 micrograms/ml and with respect to strain A-Cole 20 micrograms/ml. The frequency of spontaneous spectinomycin resistant mutants was low. The mutants grown on a medium containing spectinomycin in a concentration of 100 micrograms/ml were highly resistant to the antibiotic (at least 10000 micrograms/ml). By the main biological properties and virulence the spectinomycin resistant mutants did not differ from the initial strains.
mesh_terms: D000818:Animals; D004352:Drug Resistance, Microbial; D005604:Francisella tularensis / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D006168:Guinea Pigs; D051379:Mice; D009154:Mutation; D011817:Rabbits; D000198:Spectinomycin / Q000494:pharmacology*; D014774:Virulence
chemical_list: D000198:Spectinomycin
vernacular_title: Biologicheskaia kharakteristika rezistentnykh k spektinomitsinu shtammov tuliaremiĭnogo mikroba.