[Cloning of human genes].
The fears concerning potential hazards of man made recombinant DNA have been dismissed and the burden of compelling unnecessary safety regulations has been cleared away. The deciphering of the entire human genome at the nucleotide level is no longer an impossible task. It is based upon the utilization of cloned fragments of DNA used as specific probes. The present catalogue of cloned human genes is still small, but it will expand rapidly in the near future. There are two categories of probes: those corresponding to know genes, and those consisting of random "anonymous" DNA sequences present in genomic libraries. The increasing number of cloned probes will allow us to saturate progressively the entire genome. Medicine will benefit from this progress, first of all with regard to pre-natal and post-natal diagnosis of some genetic diseases and in the field of cancer research.
D002051:Burkitt Lymphoma / Q000235:genetics; D002648:Child; D003001:Cloning, Molecular / Q000379:methods*; D005164:Factor IX / Q000235:genetics; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D009124:Muscle Proteins / Q000235:genetics; D009136:Muscular Dystrophies / Q000235:genetics; D009857:Oncogenes; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013789:Thalassemia / Q000235:genetics
D009124:Muscle Proteins; D005164:Factor IX
Le clonage des gènes humains.