Absence of suppression in natural and induced tolerance to F antigen.
The role of suppression in natural and induced tolerance to F antigen was investigated in two sets of experiments. In the first, CBA mice were submitted to pretreatments which decrease suppression and the antibody response to self- or allo-F type was investigated. The second set of experiments involved the transfer of spleen cells from tolerized or from naturally tolerant mice into normal mice which were then primed with allo-F, as well as the co-transfer of tolerant and primed lymphocytes into normal mice, to test whether tolerant lymphocytes present suppressor cells. The results indicate that the immune response against allo-F antigen is normally kept in a low level by a suppressive mechanism, and that F-specific suppressor T cells are absent from tolerant mice.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects / Q000528:radiation effects; D007116:Immunization, Passive; D007156:Immunologic Memory; D007519:Isoantigens / Q000276:immunology*; D008099:Liver / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013934:Thymectomy; D013950:Thymus Gland / Q000528:radiation effects
D007519:Isoantigens; C030497:liver specific F antigen; D003520:Cyclophosphamide