Suppression of the proliferative response of human lymphocytes to cultured allogeneic HeLa cells by zinc.
Zinc added to the culture medium caused a dose-related suppression of the proliferative response of human lymphocytes to cultured allogeneic HeLa cells without any significant decrease in cell viability. In contrast to the response to HeLa cells, this metal ion moderately enhanced T lymphocyte response to mitogens such as phytohemagglutinin (PHA), concanavalin A (ConA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). These findings seem to indicate that zinc may be a crucial factor for the modulation of the T lymphocyte function. It can also be considered that the different effect of zinc on the proliferative responses of lymphocytes to allogeneic HeLa cells and to some soluble mitogens might reflect a difference in mechanisms between the two proliferative responses.
D006367:HeLa Cells; D006801:Humans; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008264:Macrophages / Q000276:immunology; D008934:Mitogens / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
D008934:Mitogens; D015032:Zinc; D013936:Thymidine