Suppression of contact sensitivity to picryl chloride. Interaction between T suppressor auxiliary cells, suppressor factors and macrophages.
Immunization with picryl chloride generates cyclophosphamide resistant T immune cells (TDH) as well as cyclophosphamide sensitive T suppressor auxiliary cells (Ts-aux). T suppressor efferent cells do not inhibit effector phase of contact sensitivity in the absence of Ts-aux. These cells as well as macrophages adsorb TNP--T suppressor factor (TNP-TSF) and on these "armed" cells suppression may be transferred into recipients. Interactions between T-suppressor cells, their factors, Ts-auxiliary cells and macrophages are discussed.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D010853:Picryl Chloride / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D003520:Cyclophosphamide; D010853:Picryl Chloride