Heterogeneity of an anti-H-2 I-A response as determined by cloned T cell reactivity.
T lymphocytes activated against the I-Aq gene product in primary mixed leukocyte culture (MLC) exhibit an unusually strong cross-reactivity against all third-party stimulating strains tested in secondary MLC. Through the development of anti-I-Aq clones, this cross-recognition has been shown to result from the activation of a heterogeneous T lymphocyte population bearing receptors that recognize the I-Aq gene product differently, yet specifically. The determination of functional activities of the anti-I-Aq cloned cells, e.g., lymphokine production and ability to induce lethal graft-vs-host disease, suggested even further heterogeneity in T cells grouped according to their similar cross-reactive pattern.
D000818:Animals; D015478:Antigens, Heterophile / Q000235:genetics / Q000276:immunology*; D002999:Clone Cells / Q000276:immunology; D003429:Cross Reactions; D005260:Female; D005802:Genes, MHC Class II; D007518:Isoantibodies / Q000096:biosynthesis* / Q000235:genetics; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D014176:Protein Biosynthesis; D013601:T-Lymphocytes / Q000276:immunology*
D015478:Antigens, Heterophile; D007518:Isoantibodies; C030036:anti-H-2 antibodies