title: [Effect of multiple injections of hepatic chalones on the multiplication of hepatoma 22a cells and the primary immune response in the body].
abstract: The amount of dividing and DNA-synthesizing cells was investigated in 22a hepatoma after injection of hepatic chalones to mice every 6 hours. Chalones were proved to lower sharply these indices, 3-6 h later they reach minimal values and remain at the lower level during the whole period of the investigation (27 h). Despite a pronounced inhibitory effect in the proliferating cell population there is a tendency to rhythmic proliferative processes. After cessation of prolonged (8 days) injections of the preparation the level of cell proliferation restores only by the 48th h after the last injection and the lifetime of animals with the tumour becomes twice as long. The preparation used possesses no immune properties.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000276:immunology; D002455:Cell Division / Q000187:drug effects; D006131:Growth Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D007114:Immunization; D008099:Liver / Q000032:analysis; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D009928:Organ Specificity; D051381:Rats
chemical_list: D006131:Growth Inhibitors
vernacular_title: Vliianie mnogokratnogo vvedeniia pechenochnykh keĭlonov na razmnozhenie kletok gepatomy 22a i pervichnyĭ immunnyĭ otvet organizma.