Antibody-specific immunoregulation is restricted by the major histocompatibility gene complex.
Experiments were carried out to examine the major histocompatibility complex (MHC) restriction of an antibody-specific immunoregulatory function that develops following conventional immunization with hapten-carrier conjugates. It was found that carrier-primed hosts reconstituted with Ly-2.2+ T cells from hapten-carrier-immunized donors were able to suppress adoptively transferred primary B cells. The effective suppression of primary B cell responses was dependent on syngeny between the suppressing T cell population and the target B cells at both MHC and Igh. These findings indicate that T cells that function through the recognition of B cell antibody are restricted in their function by gene products of the MHC, similar to the restrictions observed for the recognition of conventional antigens.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D007108:Immune Tolerance; D007143:Immunoglobulin Heavy Chains / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007143:Immunoglobulin Heavy Chains