[Effect of riboxine on the ATPase activity and adenine nucleotide content in the myocardium in experimental myocardial infarct].
Experiments on rabbits with experimental myocardial infarction were made to determine the content of adenyl nucleotides and Ca2+-dependent ATPase activity of myosin outside the zone of necrosis. It was found that on the 5th day the animals injected with 40 mg/kg riboxine intravenously on a daily basis manifested a 36% increase in the content of AMP and a 81% increase in the CA2+-dependent ATPase activity as compared with untreated controls. Injection of riboxine did not produce any appreciable changes in the content of ATP and ADP. Riboxine appears to stimulate the utilization of the energy of macroenergic binding of adenyl nucleotides with myocardial cells.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D005260:Female; D006321:Heart / Q000187:drug effects*; D007288:Inosine / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
D000227:Adenine Nucleotides; D007288:Inosine; D009218:Myosins; D000252:Calcium-Transporting ATPases
Vliianie riboksina na ATF-aznuiu aktivnost' i soderzhanie adenilovykh nukleotidov v serdechnoĭ myshtse pri éksperimental'nom infarkte miokarda.