[Ventilatory disorders and sleep anomalies in severe chronic obstructive respiratory insufficiency. Effects of nocturnal oxygen therapy].
The influence of nocturnal oxygen therapy on ventilatory disorders and sleep abnormalities was evaluated in 5 male, non-obese patients with advanced chronic obstructive pulmonary disease (COPD). All had hypoxia, severe airway obstruction (FEV1 less than 1 l) and pulmonary arterial hypertension at rest; 3 had PaCO2 values above 50 mmHg. Polygraphic recordings were taken throughout the night, the patients breathing either air or oxygen, they included EEG, electromyography of chin muscles, eye movements, O2sat., thoraco-abdominal mechanics and nasal flow. Improvement in the quality of sleep under oxygen was observed in all patients, with an increase from 6.1% (air) to 14.6% (oxygen) in the R.E.M. (Rapid Eye Movement) sleep phase duration to total sleep duration ratio, and an increase from 8 to 12 in the number of episodes of apnoea (arrest of nasal flow greater than 10 sec). Oxygen also had a favourable influence on the number and amplitude of O2 desaturation phases (delta O2sat. greater than 4%) and on the time spent in desaturation, which decreased from 5.12% (air) to 3.7% (oxygen). Correction of the hypoxaemic episodes was partial in those R.E.M. sleep phases when these episodes were most severe and occurred in the absence of apnoea.
D000368:Aged; D004569:Electroencephalography; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D012120:Respiration Disorders / Q000209:etiology / Q000628:therapy*; D012890:Sleep; D012891:Sleep Apnea Syndromes / Q000209:etiology; D012893:Sleep Wake Disorders / Q000209:etiology / Q000628:therapy*; D012895:Sleep, REM
Perturbations ventilatoires et anomalies du sommeil de l'insuffisant respiratoire chronique obstructif grave. Incidence d'une oxygénothérapie nocturne.