Genetic control and effector cells in host-versus-graft responses to H-Y antigen in mice.
T cell responses to the male-specific H-Y antigen in mice include skin graft rejection, delayed-type hypersensitivity and cytotoxic T cell responses; these are under complex H-2 and non-H-2 Ir gene control. The effector cells for these two in vivo responses are Ly 1+2-, and the cytotoxic T cell effectors generated in secondary mixed lymphocyte reactions in vitro are Ly1+2+, although their development requires the presence of Ly 1+2- T helper cells. We investigated the Ir gene control of another in vivo response to H-Y, the host-versus-graft response (HVGR), measured by popliteal lymph node enlargement. The strain distribution pattern (SDP) of primary and secondary HVG responses to H-Y indicates that there are both H-2 and non-H-2 Ir genes involved in controlling responsiveness. Cell transfer of the secondary response identifies an Ly 1+2- effector T cell for this response: this information together with the SDP of cytotoxic T cell responses suggests that the HVGR may represent activation of the T helper population involved in the generation of cytotoxic T cells.
D000818:Animals; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D006182:H-Y Antigen / Q000235:genetics* / Q000276:immunology; D006789:Host vs Graft Reaction; D007114:Immunization; D007116:Immunization, Passive; D066298:In Vitro Techniques; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008912:Minor Histocompatibility Loci; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D006183:H-2 Antigens; D006182:H-Y Antigen