title: In vitro activity of norfloxacin in synthetic media and human urine compared to that of cinnoxacin, nalidixic acid and pipemidic acid.
abstract: Activity of norfloxacin was compared to that of cinnoxacin, nalidixic acid and pipemidi acid in DST-agar and human urine solidified by adding 1.2% agar. Norfloxacin was the most active compound when tested on DST-agar but the MIC values increased from 64 to 128 fold when tested in urine. Other compounds also showed an increase in MIC in urine-agar, but the increase was less marked. MICs for norfloxacin in DST-agar and Müller-Hinton-Agar were similar. Higher concentrations were required in Müller-Hinton-Broth than in Müller-Hinton-Agar.
mesh_terms: D000362:Agar; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002937:Cinoxacin / Q000494:pharmacology*; D003470:Culture Media; D006801:Humans; D009268:Nalidixic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009643:Norfloxacin; D010876:Pipemidic Acid / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D014556:Urine
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D009539:Nicotinic Acids; D011724:Pyridazines; D009268:Nalidixic Acid; D000362:Agar; D002937:Cinoxacin; D010876:Pipemidic Acid; D009643:Norfloxacin