Huntington's disease: biochemical prediction by determination of GABA synthesis of cultured fibroblasts.
GABA synthesis in skin fibroblasts from patients with Huntington's chorea was compared with that in a control group by means of the highly specific 3H-muscimol radioreceptor assay. A significantly increased rate of GABA synthesis was found in the group with Huntington's chorea in an early cell passage. The possible use of this method for early diagnosis of Huntington's chorea is considered.
D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000175:diagnosis / Q000378:metabolism*; D011869:Radioligand Assay / Q000379:methods; D012867:Skin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D005680:gamma-Aminobutyric Acid