[Myocardium damage in experimental anemia and its prevention with the antioxidant ionol].
Rats with hemolytic (phenylhydrazine) anemia were shown to develop simultaneously with hypertrophy of the myocardium marked damages of cardiomyocytes of the type of I-III degree contractures, myocytolysis, vacuolation, fatty infiltration, small focal necrosis as well as a peculiar form of damages defined as "central lumpy degeneration". An inhibitor of lipid peroxidation, antioxidant ionol, decreases the extent of myocardial hypertrophy and the intensity of the above morphological changes in cardiomyocytes. This indicates a significant role of lipid peroxidation in myocardial damage in hemolytic anemia and the importance of research on the use of antioxidants in combined treatment of cardial disorders in patients with anemia.
D000743:Anemia, Hemolytic / Q000150:complications* / Q000401:mortality; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D006651:Histocytochemistry; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene
Povrezhdeniia serdechnoĭ myshtsy pri éksperimental'noĭ anemii i ikh preduprezhdenie s pomoshch'iu antioksidanta ionola.