title: [Effect of nicotinamide on generalized convulsions in mice].
abstract: It was shown in acute experiments on mice that nicotinamide in doses of 250-500 mg/kg given intraperitoneally increased the latent period of corasole clonico-tonic convulsions without affecting their expressiveness and mortality. When given in a dose of 1000 mg/kg nicotinamide prevented clonico-tonic convulsions and mortality, and considerably raised the latent period of convulsions and the lifespan of the animals intoxicated with thiosemicarbazide and strychnine. The expressiveness of the nicotinamide effects depended on the time of its administration.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D009536:Niacinamide / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D009536:Niacinamide; D005680:gamma-Aminobutyric Acid
vernacular_title: Vliianie nikotinamida na generalizovannye sudorogi u mysheĭ.