title: Androgen regulation of secretions in the sebaceous-like uropygial gland of the male Japanese quail.
abstract: The uropygial gland of the male quail is a sebaceous-like, androgen-dependent structure. The waxes secreted by this gland consist of fatty acids esterified by alkane-2,3-diols. In adult male quail the relative concentrations of all fatty acids were not affected by castration and testosterone treatment; but in contrast, the relative concentration of dodecane diol was found to be correlated with the androgen levels. In castrated quail administration of testosterone induced an increase in the dodecane diol percentage which was blocked by protein-synthesis inhibitors. Furthermore, the effects of testosterone were found to be neutralized by the administration of cyproterone acetate. Consequently it may be stated that the relative concentration of dodecane diol is indeed a very good marker for androgenicity in the uropygial gland of the male quail. This experimental model seems well suited for evaluating the stimulators and inhibitors of the activity of the sebaceous gland.
mesh_terms: D000818:Animals; D002988:Cloaca / Q000033:anatomy & histology / Q000187:drug effects; D003370:Coturnix / Q000502:physiology*; D003513:Cycloheximide / Q000494:pharmacology; D003534:Cyproterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017373:Cyproterone Acetate; D003609:Dactinomycin / Q000494:pharmacology; D006120:Grooming; D008027:Light; D050356:Lipid Metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011691:Puromycin / Q000494:pharmacology; D011784:Quail / Q000502:physiology*; D012627:Sebaceous Glands / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*; D014885:Waxes / Q000378:metabolism*
chemical_list: D014885:Waxes; D003609:Dactinomycin; D013739:Testosterone; D011691:Puromycin; D017373:Cyproterone Acetate; D003513:Cycloheximide; D003534:Cyproterone