Molecular events in the processing of avidin by antigen-presenting cells (APC). I. The immune response of T lymphocytes to avidin is regulated by H-2-linked Ir genes.
The immune response of T lymphocytes to avidin was measured by proliferative assays, antibody production and delayed-type hypersensitivity. Mice of H-2k haplotypes were found to be low responders, whereas mice of other haplotypes, and particularly of H-2s, were high responders. Ir genes controlling this response were mapped to the I subregion of H-2. Helper T cells were found to be responsible for the Ir phenotype of antibody production. These results indicate the feasibility of using the avidin-biotin complex as a tool for studying molecular mechanisms by which antigens under Ir gene control are processed and presented to T lymphocytes.
D000818:Animals; D001360:Avidin / Q000276:immunology*; D002874:Chromosome Mapping; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D008285:Major Histocompatibility Complex; D051379:Mice; D010047:Ovalbumin / Q000031:analogs & derivatives*; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D006183:H-2 Antigens; D001360:Avidin; D010047:Ovalbumin