[Pathogenesis of post-irradiation infection. 2. Role of polynucleated neutrophils in the defense of irradiated rats against Yersinia enterocolitica].
Wistar R inbred rats showed a substantial mortality when they were given Yersinia enterocolitica eight days after a 6.5 Gy total body irradiation. The possibility to abolish the high susceptibility of these irradiated rats to Yersinia enterocolitica by intravenous injections of isogenic neutrophils is presented: irradiated rats injected with 7 to 10.10(7) isogenic neutrophils, by the intravenous route, just before or after the administration of Yersinia enterocolitica, were not susceptible. On the contrary, control irradiated rats, not transfused, were killed by the same bacterial challenge.
D000818:Animals; D005260:Female; D009504:Neutrophils / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014916:Whole-Body Irradiation / Q000009:adverse effects*; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica
Pathogénie des infections après irradiation. 2. Rôle des polynucléaires neutrophiles dans la défense des rats irradiés contre Yersinia enterocolitica.