[Different behavior of the rat vas deferens of castrated animals and those treated with cyproterone acetate].
The effects of castration and treatment with the antiandrogen cyproterone acetate (CPA) on the responses of the vas deferens of the rat induced by phenylephrine, KCl and BaCl2 has been studied. Both castration and CPA induced a spontaneous motility in the rat vas deferens. Castration produces a decrease of the response amplitude induced by phenylephrine and KCl and an increase of those induced by BaCl2 in animals killed 30 days after castration. CPA increases the response amplitude induced by phenylephrine and KCl without modifying those induced by BaCl2. These results suggest that the antiandrogen CPA produces modifications qualitatively different from castration.
D000818:Animals; D001464:Barium / Q000494:pharmacology; D017609:Barium Compounds; D002369:Castration; D002712:Chlorides; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014649:Vas Deferens / Q000187:drug effects*
D017609:Barium Compounds; D002712:Chlorides; C024986:barium chloride; D010656:Phenylephrine; D001464:Barium; D017373:Cyproterone Acetate; D011189:Potassium Chloride; D003534:Cyproterone
Diferente comportamiento del conducto deferente de rata de animales castrados y tratados con acetato de ciproterona.