Detoxication of industrial pollutants by the glutathione glutathione-S-transferase system in the liver of Anabas testudineus (Bloch).
The interrelationship of reduced glutathione (GSH) and glutathione-S-transferase in the liver of a freshwater climbing perch Anabas testudineus (Bloch) exposed to common industrial pollutants has been studied. In both short- and long-term treatments there was a concomitant decrease in reduced glutathione profile and an increase in glutathione-S-transferase activity. It may be surmised that the majority of xenobiotics of industrial origin are detoxicated by the glutathione glutathione-S-transferase pathways enabling the fish to survive exposure to the additive and/or synergistic toxicity of mixtures of poisons.
D000641:Ammonia / Q000633:toxicity; D000818:Animals; D002104:Cadmium / Q000633:toxicity; D019256:Cadmium Chloride; D005399:Fishes; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008627:Mercuric Chloride; D008628:Mercury / Q000633:toxicity; D019800:Phenol; D010636:Phenols / Q000633:toxicity; D014873:Water Pollutants / Q000633:toxicity*
D010636:Phenols; D014873:Water Pollutants; D002104:Cadmium; D019800:Phenol; D008627:Mercuric Chloride; D000641:Ammonia; D005982:Glutathione Transferase; D008628:Mercury; D005978:Glutathione; D019256:Cadmium Chloride