A new method for radiolabeling of Gelfoam particles with 99mTc.
Embolization of the spleen and other organs using Gelfoam has recently gained acceptance as a therapeutic procedure. A simple non-invasive determination of the placement of Gelfoam particles is needed and this requires labeling Gelfoam with radionuclides. We have developed a simple, reliable reproducible, and inexpensive method of labeling Gelfoam with 99mTc using commercial sulfur colloid kits. Optimal reaction conditions include room temperature incubation for 60 min at 12 rpm rotation. In vitro stability indicated no loss of 99mTc activity up to 3 h post labeling. Imaging of intra-arterially placed 99mTc Gelfoam at 1 h and 24 h in animals and humans has consistently produced well-defined images of the radioemboli.
D000818:Animals; D004164:Diphosphonates; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage*; D007553:Isotope Labeling / Q000379:methods*; D008297:Male; D004369:Pentetic Acid; D011933:Reagent Kits, Diagnostic; D012709:Serum Albumin; D013455:Sulfur; D013667:Technetium; D013668:Technetium Tc 99m Aggregated Albumin; D013669:Technetium Tc 99m Medronate; D016284:Technetium Tc 99m Pentetate / Q000031:analogs & derivatives*; D016698:Technetium Tc 99m Pyrophosphate; D013671:Technetium Tc 99m Sulfur Colloid; D014003:Tin Polyphosphates
D004164:Diphosphonates; D011933:Reagent Kits, Diagnostic; D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; D014003:Tin Polyphosphates; C034230:technetium Tc 99m-Sn-DTPA; C017742:technetium Tc 99m stannous pyrophosphate; D013671:Technetium Tc 99m Sulfur Colloid; D016698:Technetium Tc 99m Pyrophosphate; C023568:technetium Tc 99m (Sn)methylenediphosphonate; D013455:Sulfur; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate; D013669:Technetium Tc 99m Medronate