title: [Antimitochondrial antibodies against the M2-antigen with immune vasculitis and discoid lupus erythematosus without proof of liver disease].
abstract: We have seen a 54-year-old patient with discoid lupus erythematosus and biopsy-proven vasculitis with granular deposits of complement and immunoglobulins in small subcutaneous vessels of clinically normal skin. Serologically, neither antinuclear antibodies nor antibodies against double-stranded DNA, Sm-Ag nor ribonucleoprotein could be demonstrated whereas the immunofluorescence test for antimitochondrial antibodies was positive during the whole observation period of 15 months. The further characterisation of the antimitochondrial antibodies by a newly described radio-immuno-assay demonstrated that the antibodies are directed against the primary biliary cirrhosis specific M2-antigen of mitochondria. So far, the patient, however, does not show any clinical or laboratory signs of primary biliary cirrhosis and a liver biopsy showed no evidence of that disease. It is discussed whether there is a coincidence of different autoimmunopathies or if the findings are symptoms of a single disease. Follow-up study might solve this open question.
mesh_terms: D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D002196:Capillaries / Q000276:immunology; D005260:Female; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology; D008105:Liver Cirrhosis, Biliary / Q000276:immunology; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis / Q000276:immunology*; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology*; D012867:Skin / Q000098:blood supply; D014657:Vasculitis / Q000175:diagnosis / Q000276:immunology*
chemical_list: D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens
vernacular_title: Antimitochondriale Antikörper gegen das M2-Antigen mit Immunvaskulitis und diskoidem Lupus erythematodes ohne Nachweis einer Lebererkrankung.