Effects of auxiliary liver transplantation on oxygen consumption in the graft and recipient's liver mitochondria. Possible inter-liver regulating mechanism.
Studies were made on inbred rats of Lewis strain with heterotopically transplanted syngeneic liver to assess the effect of this type of liver transplantation on the liver mitochondria. Mitochondria were isolated from own and transplanted liver in 1 and 3.5 months after auxiliary liver transplantation. They showed a progressive decrease in oxygen uptake and citrulline production accompanied by an increase in ATP-ase activity in mitochondria of the recipient's liver and of the graft, as well as diminution in their sensitivity to dinitrophenol, especially in the transplant mitochondria. The results suggest an existence of inhibitory factors transferred by the serum bringing the energetic function in recipient and auxiliary liver mitochondria to a similar level.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002956:Citrulline / Q000096:biosynthesis; D005260:Female; D008099:Liver / Q000378:metabolism; D016031:Liver Transplantation; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption; D011167:Portacaval Shunt, Surgical; D051381:Rats; D011917:Rats, Inbred Lew
D002956:Citrulline; D000251:Adenosine Triphosphatases