[Effects of dimaprit, an H2 receptor agonist, on blood levels of corticosterone in the rat].
These experiments were performed in order to further clarify the role played by hystamine in the control of hypothalamus-hypophisis-adrenal axis. To this aim we evaluated the effect of Dimaprit, a H2 agonist on plasma corticosterone levels. This drug was administered intraperitoneally or i.c.v. at the doses of 25, 50 and 100 mg/kg or 100 gamma/animal respectively. The administration i.p. at the dose of 100 mg/kg increased plasma-corticosterone levels whereas Dimaprit, injected intraventricularly did not modify plasma-corticosterone levels. These results seem to suggest that Dimaprit stimulates corticosterone secretion at a peripheral level.
D000818:Animals; D003345:Corticosterone / Q000097:blood*; D017259:Dimaprit; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011968:Receptors, Histamine / Q000378:metabolism*; D011970:Receptors, Histamine H2 / Q000378:metabolism*; D013890:Thiourea / Q000008:administration & dosage / Q000494:pharmacology*
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D013890:Thiourea; D003345:Corticosterone; D017259:Dimaprit
Effetti del dimaprit, un agonista dei recettori H2, sui livelli di corticosterone plasmatico nel ratto.