title: Gonococcal urethritis.
abstract: Gonorrhea continues to maintain its position as the most common reportable infectious disease in the United States. Penicillin is still the antibiotic of choice for the treatment of uncomplicated gonococcal urethritis in most of the United States, but the increasing incidence of penicillinase-producing Neisseria gonorrhoeae (PPNG) in many areas of the world necessitates a reconsideration of standard therapy. In addition to penicillin resistance, the gonococcus is also developing resistance to spectinomycin and tetracycline, which further complicates the choice of therapy.
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000667:Ampicillin / Q000627:therapeutic use; D001431:Bacteriological Techniques; D002511:Cephalosporins / Q000627:therapeutic use; D003470:Culture Media; D004338:Drug Combinations / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000150:complications / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000201:enzymology; D010400:Penicillin G / Q000627:therapeutic use; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis; D000198:Spectinomycin / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D013754:Tetracyclines / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014526:Urethritis / Q000382:microbiology*
chemical_list: D002511:Cephalosporins; D003470:Culture Media; D004338:Drug Combinations; D013754:Tetracyclines; D004917:Erythromycin; D000667:Ampicillin; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000198:Spectinomycin; D014295:Trimethoprim; D010405:Penicillinase; D013420:Sulfamethoxazole; D010400:Penicillin G