Interaction of EEG sleep, antidepressants, and affective disease.
The major sleep characteristics of depression are summarized and new EEG sleep studies of antidepressants, including preliminary data on desipramine and zimelidine, are described. The relationship of steady-state plasma amitriptyline levels to REM sleep and the use of EEG sleep measures as predictors of clinical response to tricyclics will also be discussed. The effects of antidepressant agents on sleep are immediate and pronounced, and studies of these drug-induced effects may also represent a rational method for drug classification.
D000639:Amitriptyline / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D003891:Desipramine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D004569:Electroencephalography; D006801:Humans; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology; D015031:Zimeldine
D000928:Antidepressive Agents; D000639:Amitriptyline; D015031:Zimeldine; D001977:Brompheniramine; D003891:Desipramine