Accessory cells in immune suppression. I. Role of I-A+ accessory cells in effector phase idiotype-specific suppression of myeloma function.
The suppression of MOPC 315 myeloma cells by idiotype-specific effector Ts requires the presence of non-immune AC. This requirement was demonstrated in cultures where myeloma targets and Ts were separated by cell-impermeable membranes or were in direct contact. The AC were adherent, radioresistant, and present in peritoneal exudates and in FcR+ as well as FcR- fractions of low density splenocytes; they bore cell surface I-A determinants and did not have to be H-2 compatible with myeloma cells and Ts. These studies demonstrate a novel role for Ia+ AC in immune regulation, and suggest that their accessory function may involve processing of T lymphocyte-derived suppressor factors or presentation of such factors to target cells.
D000818:Animals; D002460:Cell Line; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D008211:Lymphocyte Cooperation; D008222:Lymphokines / Q000502:physiology; D008264:Macrophages / Q000145:classification / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009194:Myeloma Proteins / Q000276:immunology*; D010641:Phenotype; D013491:Suppressor Factors, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007130:Immunoglobulin Idiotypes; D008222:Lymphokines; D009194:Myeloma Proteins; D013491:Suppressor Factors, Immunologic