[Modulating effects of phenothiazines on mast cells deformities induced by colchicine. Importance of calcium].
The shape changes of peritoneal rat mast cells induced by colchicine are completely inhibited by trifluoperazine (10(-4) M), known to inhibit calmodulin, and by EDTA (2 X 10(-3) M). Promethazine and chlorpromazine increase these modifications up to 10(-4) M and inhibit them at higher concentrations.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology*; D007700:Kinetics; D007962:Leukocytes / Q000187:drug effects / Q000648:ultrastructure; D008407:Mast Cells / Q000187:drug effects / Q000648:ultrastructure*; D010640:Phenothiazines / Q000494:pharmacology*; D011398:Promethazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014268:Trifluoperazine / Q000494:pharmacology
D010640:Phenothiazines; D014268:Trifluoperazine; D011398:Promethazine; D003078:Colchicine; D002746:Chlorpromazine
Effets modulateurs des phénothiazines sur les déformations mastocytaires induites par la colchicine. Importance du calcium.