title: [Effect of 13-cis-retinoic acid (Ro 4-3780) in the therapy of severe cystic acne].
abstract: Five subjects with serious cystic acne, two of which were also affected by hydrosadenitis, were examined during a treatment with 13-cis-retinoic acid. The drug was given at decreasing doses: 0.9 mg/kg body weight for a period of six weeks, followed by a second six weeks period at 0.6 mg/kg and lastly by another 9 months period at 0.3 mg/kg. The patients had a good response to the treatment with a rapid reduction of the number and of the severity of the acneic lesions, with the only exception of one subject who had a relapse at the 18th week. This study, limited to a small number of patients, suggest that 13-cis-retinoic acid may be used in severe cystic acne with a higher dosage in the presence of complicating hydrosadenitis.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D006801:Humans; D015474:Isotretinoin; D013997:Time Factors; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D014212:Tretinoin; D015474:Isotretinoin
vernacular_title: Effetti dell'acido 13-cis-retinoico (Ro 4-3780) nella terapia dell'acne cistica grave.