title: Comparison between 99Tcm-porcine plasmin and 99Tcm-labelled erythrocytes in diagnosis of deep vein thrombosis.
abstract: In 20 patients with suspect deep venous thrombosis (DVT), scintillation detector measurements were performed over each leg during the first 60 min after intravenous injection of 99Tcm-porcine plasmin. Thereafter, 99Tcm-labelled autologous erythrocytes were injected i.v. and repeat measurements were performed. Finally, scintillation camera images of both legs were obtained. Phlebography was used as a reference method. A close relationship (P less than 0.01) was found between the scintillation detector measurements, both in patients with DVT (n = 11) and in patients without DVT (n = 9). Thus, 99Tcm-plasmin is not specifically bound to the thrombus. Rather the clinical utility of the test depends mainly on circulatory changes secondary to the thrombus. Scintillation camera images of 99Tcm-erythrocytes in the legs were not useful for diagnosis of DVT in the calves but showed a high specificity for DVT in the popliteal and femoral veins.
mesh_terms: D000328:Adult; D000368:Aged; D004912:Erythrocytes; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D005260:Female; D005341:Fibrinolysin; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010690:Phlebography; D010781:Photography; D012588:Scintillation Counting; D013667:Technetium; D013924:Thrombophlebitis / Q000000981:diagnostic imaging*
chemical_list: D015609:Organotechnetium Compounds; C034360:technetium Tc 99m plasmin; D013667:Technetium; D005341:Fibrinolysin