title: [Population genetics of the inhabitants of the European northern RSFSR. VI. The dynamics of the genetic load].
abstract: The dynamics of the lethal equivalents in two rural populations of Archangelsk regions during the periods from 1930 to 1953 and from 1954 to 1970 was investigated. The outcomes of 1617 pregnancies for 500 couples were analysed. The coefficient of inbreeding varied fo these couples from 0.001 to 0.08. For computing the genetic load, we followed the the methodology suggested by Morton, Crow and Muller in S. Smith's modification. The importance of comprehensive determination of inbreeding coefficient for reliable estimation of the genetic load was demonstrated. By comparing the two groups, it was shown that the coefficient B diminished approximately twice and the B/A ratio increased in both populations also by the factor of two. It is supposed that the diminishing of the number of lethal equivalents can be explained by a decrease in natural selection pressure. It is also supposed, that the segregational load is more sensitive to the decrease in natural selection pressure.'
mesh_terms: D003241:Consanguinity; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008297:Male; D011247:Pregnancy; D012424:Rural Population; D012426:Russia; D012641:Selection, Genetic
vernacular_title: K populiatsionnoĭ genetike naseleniia evropeĭskogo severa RSFSR. Soobshchenie VI. Dinamika geneticheskogo gruza.