Facilitation by alpha-adrenolytics of apomorphine gnawing behavior: depression of threshold apomorphine concentration in the striatum of the rat.
Adrenolytics, aceperone and phenoxybenzamine, increased significantly the incidence of gnawing induced in the rat by a medium dose of apomorphine. The experiments in which the rats were killed at the onset of stereotyped gnawing to assess the threshold concentration of apomorphine in the striatum necessary to evoke this type of behavior have shown that these threshold concentrations were significantly reduced. It is concluded that the facilitation by adrenolytics of gnawing response to apomorphine is caused by an increase in the sensitivity of structures involved in this phenomenon to this dopaminergic stimulant.
D000818:Animals; D001058:Apomorphine / Q000378:metabolism / Q000494:pharmacology*; D002090:Butyrophenones / Q000494:pharmacology*; D003342:Corpus Striatum / Q000502:physiology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D002090:Butyrophenones; D010643:Phenoxybenzamine; D001058:Apomorphine