title: The problem of transition from the chemical to the biological evolution: some possible solutions.
abstract: On the basis of evidence that several low-molecular-weight substances as well as enzymes are compartmentalised within the so-called soluble phase of the cell, and other considerations, it is argued that DNA may not contain information for certain types of organisation found in living cells. It may be necessary for a cell to possess the "non-DNA-controlled" organisation for performance of its minimum functions; such organisation would then also serve as a "template" for its appearance in the daughter cell. The problem of transition from chemical to biological evolution (that is, the formation of the "first cell") may be essentially the problem of emergence of such intracellular organisation for which information may not reside in DNA. Two possible mechanisms through which this may have happened are stated.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004247:DNA / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D008957:Models, Genetic; D009492:Neurospora crassa / Q000235:genetics; D000069497:Origin of Life; D013698:Templates, Genetic; D013769:Tetrahymena pyriformis / Q000235:genetics
chemical_list: D004247:DNA