Platelet storage pool disease in women.
Menstrual abnormalities in adolescents are usually diagnosed as dysfunctional uterine bleeding. It is generally regarded as characteristic of the young hypophyseal-pituitary system, which with time will stop naturally. The possibility of platelet storage pool diseases as a cause of irregular bleeding is often overlooked. We have treated five patients with proven or suspected platelet storage pool disease who had a history of adolescent hypermenorrhea and other bleeding. Patients with this type of history should have a comprehensive hematologic evaluation because platelet storage pool disease is not demonstrated by conventional coagulation studies. Our patients were treated with medroxyprogesterone acetate, oral contraceptives, and an avoidance of aspirin.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D002648:Child; D004837:Epinephrine; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D008599:Menstruation Disturbances / Q000209:etiology*; D010974:Platelet Aggregation
D000244:Adenosine Diphosphate; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D004837:Epinephrine