Cells with Fc gamma receptors from normal donors suppress granulocytic macrophage colony formation.
We investigated the role of normal human marrow cells with Fc receptors for IgG (Fc gamma+) on autologous granulocyte-macrophage colony (GM-CFC) formation. It was found that Fc gamma+ normal human marrow cells, both with (E+) or without receptors for sheep erythrocytes suppressed GM-CFC at as low a concentration as 0.25 X 10(5) cells/ml of culture. A similar effect was observed with E- Fc gamma+ but not E+ Fc gamma+ peripheral blood cells. Suppression by Fc gamma+ cells did not require mitogen activation and was not inactivated by irradiation (2000 R). This report presents a new in vitro regulatory mechanism for GM-CFC growth in normal donors.
D001853:Bone Marrow / Q000201:enzymology; D001854:Bone Marrow Cells; D002469:Cell Separation; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000166:cytology; D006801:Humans; D008264:Macrophages / Q000166:cytology; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic