[Effect of a chalone-containing preparation from Ehrlich ascites tumor on DNA synthesis and cell division in the tumor in relation to the time of day].
The mitosis inhibitory action of chalone-containing preparation of the Ehrlich ascite tumour was shown to depend on the time of its administration on round the clock, and on the circadian rhythm phase of the mitotic activity in this tumour. This allowed a conclusion that the chalone system of the tumour may be involved in the formation of the circadian rhythm of cell division. It was found that Ehrlich's ascite tumour chalone system regulated DNA synthesis influencing the cell passage from G1-phase of the mitotic cycle to S-phase, and the processes occurring during S-phase.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D006131:Growth Inhibitors / Q000494:pharmacology*; D007399:Interphase / Q000187:drug effects; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009368:Neoplasm Transplantation
D004273:DNA, Neoplasm; D006131:Growth Inhibitors
Vliianie keĭlonsoderzhashchego preparata iz astsitnoĭ opukholi Erlikha na sintez DNK i delenie kletok v opukholi v zavisimosti ot vremeni sutok.