title: The influence of membrane potentials on reaction rates. Control in free-energy-transducing systems.
abstract: The influence of membrane potentials on the rates of reactions involving the translocation of charged species across the membrane has been studied. Depending on the location of the rate-limiting step relative to the potential gradient either the forward or the backward rate is most strongly influenced by the potential. The rate of a proton translocation process in general is thus not a unique function of the protonmotive force. It is essential to include an explicit potential dependence in the kinetic coefficients to obtain a realistic description of the dynamics.
mesh_terms: D001693:Biological Transport, Active; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008564:Membrane Potentials; D008954:Models, Biological; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D006180:Proton-Translocating ATPases