Sulphation of contraceptive steroids.
The sulphation of a number of contraceptive steroids by rabbit tissue in vitro was investigated. With liver tissue the three synthetic gestagens (norethisterone, norgesterel and lynestrenol) were sulphated at different rates and none was sulphated as rapidly as dehydroepiandrosterone; sulphation occurred at the tertiary 17 beta-hydroxyl group. The synthetic oestrogen ethynyloestradiol was sulphated more rapidly than dehydroepiandrosterone, both mono and disulphates being formed. Of the other tissues studied, sulphation occurred with stomach and lung but not with heart, spleen, muscle, kidney or adipose tissue. These in vitro studies provide confirmation of in vivo findings regarding sulphate conjugates of the synthetic steroids.
D000818:Animals; D002250:Carbon Radioisotopes; D003276:Contraceptives, Oral; D003687:Dehydroepiandrosterone / Q000378:metabolism; D045166:Estradiol Congeners / Q000378:metabolism*; D004997:Ethinyl Estradiol / Q000378:metabolism; D005260:Female; D008234:Lynestrenol / Q000378:metabolism; D008297:Male; D009640:Norethindrone / Q000378:metabolism; D009644:Norgestrel / Q000378:metabolism; D011817:Rabbits; D013329:Structure-Activity Relationship; D013431:Sulfates / Q000378:metabolism*
D002250:Carbon Radioisotopes; D003276:Contraceptives, Oral; D045166:Estradiol Congeners; D013431:Sulfates; D009644:Norgestrel; D004997:Ethinyl Estradiol; D003687:Dehydroepiandrosterone; D008234:Lynestrenol; D009640:Norethindrone