title: [Induction, by 17 beta-estradiol, of thymidine kinase activity in uteri of rats].
abstract: In uteri from adult female rats, Thymidine Kinase activity varied during ovarian cycle and was maximum at metestrus. Subcutaneous injections of 5, 10 or 25 ng of estradiol-17 beta to immature female rats, resulted in a 3, 5 or 10 fold increase of enzyme activity. Moreover, Thymidine Kinase activity was decreased by injection of medroxyprogesterone alone or associated with estradiol-17 beta. From these results it seemed that Thymidine Kinase activity in rats uteri was specifically induced by estradiol-17 beta.
mesh_terms: D000375:Aging; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D008525:Medroxyprogesterone / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013937:Thymidine Kinase / Q000096:biosynthesis*; D014599:Uterus / Q000201:enzymology*
chemical_list: D004958:Estradiol; D013937:Thymidine Kinase; D008525:Medroxyprogesterone
vernacular_title: Induction, par le 17 beta-oestradiol, de l'activité de la thymidine kinase dans l'utérus de la ratte.