Effects of acute doses of zimelidine on REM sleep in rats.
Sleep EEG (7 h) were obtained from 11 rats given 5, 10, and 20 mg/kg zimelidine, and a control dose of saline. Zimelidine significantly suppressed REM sleep, lengthened REM latency, and reduced total sleep time (TST) in a dose-dependent manner. Sleep latency was not affected except at the highest dose of zimelidine. Slow-wave sleep (SWS) was not affected at any dose. The results are discussed in terms of their implication for the use of zimelidine in the clinical treatment of depression.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009115:Muridae; D011725:Pyridines / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects*; D015031:Zimeldine
D000928:Antidepressive Agents; D011725:Pyridines; D015031:Zimeldine; D001977:Brompheniramine