Differences in the kinetics of the autologous mixed lymphocyte reaction between the various connective tissue diseases.
Kinetic studies of autologous mixed lymphocyte reaction (AMLR) over 7 days were made in 86 patients with various connective tissue diseases. None was receiving any treatment and each disease group was controlled with age-sex matched healthy controls. There were exceptions, but, as a rule, SLE patients (n = 22) had decreased responses on days 6-7. This was more apparent in patients with active disease than in those with inactive disease. Patients with scleroderma (n = 21) had early (day 4) proliferative responses. Half of the patients with RA (n = 14) had early (day 3) proliferation, but as a group they had normal increase in 3HtdR uptake on day 7. Patients with primary Sjögren's syndrome showed flat curves throughout and no significant proliferation on days 6-7 of culture. The pattern found in patients with mixed connective tissue disease (n = 11) was also peculiar in that they had peak proliferative responses on day 3 and normal 3HtdR uptake on days 6 and 7 of the AMLR. The number of patients with dermatomyositis or polymyositis was small (n = 6), but they showed a significant mean decrease in uptake on days 6-7. Studies using subpopulations of stimulatory cells further indicate that these patterns reflect immunoregulatory disturbances peculiar to each disease.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology; D002455:Cell Division; D003095:Collagen Diseases / Q000276:immunology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed / Q000379:methods; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D009220:Myositis / Q000276:immunology; D012595:Scleroderma, Systemic / Q000276:immunology; D012859:Sjogren's Syndrome / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D013997:Time Factors