[Activity and appearance of isoenzyme spectrums of some lysosomal hydrolases in biopsy material of human chorion].
Activities and isozyme spectra of alpha-L-fucosidase and beta-D-hexosaminidase were similar both in biopsy material from fetal zone of placenta (chorion) and in chorion tissue obtained after abortion. Evaluation of the isozyme spectrum of these glycosidases in biopsy reeterial of chorion might be carried out for prenatal detection of fucosidosis (deficiency of alpha-L-fucosidase), Tay-Sachs disease (deficiency of hexosaminidase A) and of Sandhoff disease (deficiency of hexosaminidases A and B).
D000022:Abortion, Spontaneous; D001706:Biopsy; D002823:Chorion / Q000201:enzymology*; D004796:Clinical Enzyme Tests; D005260:Female; D054818:Hexosaminidase A; D006596:Hexosaminidases / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology*; D011247:Pregnancy; D012497:Sandhoff Disease / Q000175:diagnosis; D013661:Tay-Sachs Disease / Q000175:diagnosis; D005644:alpha-L-Fucosidase / Q000172:deficiency / Q000378:metabolism*; D001619:beta-N-Acetylhexosaminidases
D007527:Isoenzymes; D006596:Hexosaminidases; D005644:alpha-L-Fucosidase; D054818:Hexosaminidase A; D001619:beta-N-Acetylhexosaminidases
Opredelenie aktivnosti i vyiavlenie izofermentnykh spektrov nekotorykh lizosomnykh gidrolaz v bioptate khoriona cheloveka.