[Primary structure of fibrinogen, its relation to conformation and function of the molecule].
Data available in literature are generalized for the amino acid sequence of three fibrinogen chains, their homology and a possibility for their common precursor to exist. The primary structure of resistant products of fibrinogen splitting by plasmin, compactness of their space organization and mutual arrangement in the intact molecule are described. The relation between the primary structure of fibrinogen and its high specificity as a thrombin substrate is traced. Evidence is considered concerning localization of active molecule centres to provide spontaneous polymerization of fibrin.
D000595:Amino Acid Sequence; D000818:Animals; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D011487:Protein Conformation
D046911:Macromolecular Substances; D005337:Fibrin; D005340:Fibrinogen; D005341:Fibrinolysin
Pervichnaia struktura fibrinogena, ee sviaz' s konformatsieĭ i funktsieĭ molekuly.