Coagulation and platelet activation after retinal vein occlusions.
The role played by coagulation and platelet activation in the pathogenesis of retinal vein occlusions (RVO) has been evaluated by measuring beta-thromboglobulin (B-TG), circulating platelet aggregates (CPA), thromboxane B2 (TxB2) and fibrinopeptide A (FPA) in 25 patients less than 40 years old, investigated after the acute phase of RVO. FPA nd B-TG were significantly higher than in healthy subjects; CPA and TxB2 were not different. These abnormalities, found in patients free from apparent generalized vascular disease, suggest that a thrombophilic state characterized by coagulation and platelet activation is present in a high proportion of young patients with RVO.
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D007511:Ischemia / Q000150:complications; D008297:Male; D010974:Platelet Aggregation; D012160:Retina / Q000098:blood supply; D012164:Retinal Diseases / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D012169:Retinal Vein / Q000503:physiopathology*; D013929:Thromboxane B2 / Q000097:blood; D001620:beta-Thromboglobulin / Q000032:analysis
D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; D013929:Thromboxane B2