[Chronic T-cell lymphoid leukemia with helper cell phenotype].
Tumour cells of a patient with T-cell chronic lymphocytic leukemia had surface (E+, OKT3+, OKT4+, OKT8-, SIg-, Ia-) and cytochemical (properties positive reaction to acid phosphatase, acid nonspecific esterase and negative reaction to terminal deoxynucleotidyl transferase) specific for T-helper lymphocytes. They had no activity of NK and K-cells, reacted weakly to mitogens (PHA, Con A, PWM) and allogenic cells. Con A and PWM stimulated synthesis of specific receptors (OKT3 and OKT4) on the surface of malignant cells, whereas PHA decreased the amount of above receptors.
D000911:Antibodies, Monoclonal; D000920:Antibody-Dependent Cell Cytotoxicity; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000911:Antibodies, Monoclonal; D008934:Mitogens
T-kletochnyĭ khronicheskiĭ limfoleĭkoz s khelpernym fenotipom kletok.