[Action of epidermal chalone on the vaginal epithelial cell proliferation in ovariectomized mice stimulated by 17 beta-estradiol].
It has been shown that the DNA synthesis inhibitory effect of chalone on the vaginal epithelium of ovariectomized mice administered epidermal chalone three times (8, 4 and 1 h before 17-beta-estradiol injection) is dependent on chalone injection made 1 h before hormone injection. The decrease in the number of DNA synthesizing cells induced by 3-fold injection of chalone during 2 days is linked with the reduction in the level of exogenous estrogen in ovariectomized mice rather than with the duration of epidermal chalone action.
D000818:Animals; D002369:Castration; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004848:Epithelium / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006131:Growth Inhibitors / Q000494:pharmacology*; D051379:Mice; D008940:Mitotic Index / Q000187:drug effects; D013268:Stimulation, Chemical; D013997:Time Factors; D014621:Vagina / Q000187:drug effects*
D006131:Growth Inhibitors; D004958:Estradiol; D004247:DNA
Deĭstvie épidermal'nogo keĭlona na proliferatsiiu kletok épiteliia vlagalishcha ovariéktomirovannykh mysheĭ, stimulirovannuiu 17-beta-éstradiolom.