Flushing in rosacea: a possible mechanism.
Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased in all patients at the climax of flushing (mean 60%). These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D001920:Bradykinin / Q000097:blood; D003000:Clonidine / Q000494:pharmacology; D004837:Epinephrine / Q000502:physiology; D005145:Face; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D008875:Middle Aged; D012393:Rosacea / Q000097:blood / Q000503:physiopathology*; D012881:Skin Temperature
D003000:Clonidine; D001241:Aspirin; D001920:Bradykinin; D007213:Indomethacin; D008784:Methysergide; D004837:Epinephrine