Cyclic expression of low-dose paralysis.
Prior treatment (priming) with a single injection of a subimmunogenic dose of Type III pneumococcal polysaccharide results in an antigen-specific T-cell-dependent form of unresponsiveness (low-dose paralysis) mediated by suppressor T cells. Although such unresponsiveness persists for several months after priming, it is expressed in a cyclic manner with a periodicity of about 3 days. This cyclic pattern is accompanied by concurrent periods of Velban sensitivity that also are cyclic. This suggests that the maintenance of low-dose paralysis in part requires some degree of cell proliferation which proceeds in an ordered manner in response to a "signal" generated after priming with antigen.
D000818:Animals; D005260:Female; D007116:Immunization, Passive; D051379:Mice; D008807:Mice, Inbred BALB C; D010507:Periodicity; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D011135:Polysaccharides, Bacterial; C026604:pneumococcal polysaccharide, type III