[T-lymphocytes with a receptor for the immunoglobulin Fc fragment in the blood of multiple sclerosis patients].
In 12 multiple sclerosis patients and 15 healthy subjects the suppressor activity in vitro by the method of Shou et al. was determined parallelly with the number of T-lymphocytes with the receptor for the Fc fragment of immunoglobulin G (TG lymphocytes). In healthy subjects a correlation (p less than 0.05) was demonstrated between the suppressor activity of lymphocytes in vitro and the number of TG lymphocytes in the peripheral blood. On the other hand, in multiple sclerosis patients a decrease was observed frequently in the suppressor activity of these cells in vitro (especially during exacerbation of the disease) while the number of TG lymphocytes in the peripheral blood was normal or raised sometimes. Different causes of the this phenomenon in multiple sclerosis are discussed.
D000328:Adult; D002908:Chronic Disease; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
D007141:Immunoglobulin Fc Fragments; D003208:Concanavalin A
Limfocyty T z receptorem dla fragmentu Fe immunoglobuliny g w krwi chorych na stwardnienie rozsiane.