Modulation of Fc gamma receptors on I cells and monocytes by 15 hydroperoxyeicosatetranoic acid.
We investigated the effects of the 15-lipoxygenase products, 15 hydroperoxyeicosatetranoic acid (15 HPETE) and 15 hydroxyeicosatetranoic acid (15 HETE) on Fc gamma receptor expression on human T cells and monocytes. Incubation of these cells with 15 HPETE but not 15 HETE results in a shift to decreased density of Fc gamma receptors on the cell surface.
D001095:Arachidonic Acids / Q000494:pharmacology*; D002469:Cell Separation; D006801:Humans; D015289:Leukotrienes; D008054:Lipid Peroxides / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D011961:Receptors, Fc / Q000378:metabolism*; D017452:Receptors, IgG; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
D001095:Arachidonic Acids; D015289:Leukotrienes; D008054:Lipid Peroxides; D011961:Receptors, Fc; D017452:Receptors, IgG; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid