title: Coumadin-induced skin necrosis.
abstract: Two women developed coumadin-induced skin necrosis. A 16-year-old woman sustained necrosis on the leg after a single dose of the drug, and a 59-year-old woman developed gangrene of most of her left breast.
mesh_terms: D000293:Adolescent; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced*; D012867:Skin / Q000187:drug effects / Q000473:pathology; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014859:Warfarin