The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone.
The structure of rat preproatrial natriuretic factor ( preproANF ) was determined by nucleotide sequence analysis of an ANF complementary DNA clone. PreproANF is composed of a hydrophobic leader segment (20 amino acids), a precursor containing one glycosylation site (106 amino acids), and ANF (24 amino acids). Atrial natriuretic factor is located at the carboxyl terminus of the precursor molecule. The human, mouse, and rat genomes each contain a single ANF gene which is highly conserved.
D000818:Animals; D009320:Atrial Natriuretic Factor; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D009124:Muscle Proteins / Q000235:genetics*; D009318:Natriuresis; D009693:Nucleic Acid Hybridization; D051381:Rats
D009124:Muscle Proteins; D009320:Atrial Natriuretic Factor; D004247:DNA