title: Comparative penetration of metronidazole, clindamycin, chloramphenicol, cefoxitin, ticarcillin, and moxalactam into bone.
abstract: The concentrations of metronidazole, clindamycin, chloramphenicol, cefoxitin, ticarcillin, and moxalactam in the serum, femurs, and scapulae of normal rats were measured microbiologically 0.5, 1, 1, and 4 h after intravenous injection of 15-, 15-, 20-, 40-, 75-, and 30-mg/kg doses of the respective drugs. By 0.5 h metronidazole reached levels of 3.0 micrograms/g in compact femoral bone and 2.7 micrograms/g in cancellous scapular bone. Clindamycin and chloramphenicol reached levels of 8.1 and 6.1 micrograms/g, respectively, at 0.5 h. Cefoxitin penetrated bone to a level of 2.6 micrograms/g, whereas ticarcillin and moxalactam failed to reach significant levels in bone after single intravenous doses.
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002440:Cefoxitin / Q000378:metabolism; D002513:Cephamycins / Q000378:metabolism; D002701:Chloramphenicol / Q000378:metabolism; D002981:Clindamycin / Q000378:metabolism; D008795:Metronidazole / Q000378:metabolism; D009070:Moxalactam; D051381:Rats; D011919:Rats, Inbred Strains; D013982:Ticarcillin / Q000378:metabolism; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D002513:Cephamycins; D008795:Metronidazole; D002981:Clindamycin; D002701:Chloramphenicol; D002440:Cefoxitin; D013982:Ticarcillin; D009070:Moxalactam