title: Comparative effects of moxalactam and gentamicin on human polymorphonuclear leukocyte functions.
abstract: The in vitro effects of moxalactam and gentamicin on chemotactic, phagocytic, and microbicidal activities of human polymorphonuclear leukocytes have been studied. Incubation of cells with moxalactam (25 to 400 micrograms/ml) resulted in a 10 to 15% inhibition of leukocyte chemotaxis (P less than or equal to 0.10). Incubation of cells with gentamicin (5 to 40 micrograms/ml) inhibited chemotaxis more than 50% (P less than or equal to 0.50). Neither moxalactam nor gentamicin had any effect on phagocytic or microbicidal capacities of leukocytes.
mesh_terms: D002464:Cell Migration Inhibition; D002511:Cephalosporins / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009070:Moxalactam; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects
chemical_list: D002511:Cephalosporins; D002513:Cephamycins; D005839:Gentamicins; D009070:Moxalactam