Autologous mixed lymphocyte reaction in man. VIII. Deficiency of autologous mixed lymphocyte reaction in patients with selective IgA deficiency.
Autologous mixed lymphocyte reaction (AMLR) between T and non-T cells was studied in 12 patients with selective IgA deficiency. Seven of 12 patients demonstrated significantly (P less than 0.05) lower AMLR when compared to simultaneously studied age and sex matched controls. In the allogeneic MLR, T cells from patients responded normally to control non-T cells; however, non-T cells from patients were poor stimulators against normal responder T cells when compared to allogeneic MLR between different normal controls. The deficient AMLR in selective IgA deficiency further supports abnormal immune regulation and might explain the increased incidence of autoimmune phenomena and autoimmune diseases associated with selective IgA deficiency.
D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000276:immunology*; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D013601:T-Lymphocytes / Q000502:physiology; D013936:Thymidine / Q000378:metabolism
D013936:Thymidine