Susceptibility of moxalactam to beta-lactamase.
Moxalactam is not significantly susceptible to the majority of beta-lactamases produced by bacteria of clinical relevance. However, two types of enzyme--PSE2 and PSE3--from Pseudomonas aeruginosa can hydrolyze this antibiotic at a significant rate. In this respect moxalactam is similar to 7-alpha-methoxy cephem compounds, such as cefoxitin, which are also susceptible to these enzymes. Moxalactam, like other beta-lactam antibiotics having an acid function in the side chain, is a potent inhibitor of the cephalosporinase from Enterobacter cloacae (type Ia beta-lactamase).
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000201:enzymology; D002228:Carbenicillin / Q000494:pharmacology; D002511:Cephalosporins / Q000378:metabolism*; D002513:Cephamycins / Q000378:metabolism* / Q000494:pharmacology; D004347:Drug Interactions; D009070:Moxalactam; D010403:Penicillin Resistance; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002513:Cephamycins; D001618:beta-Lactamases; D002228:Carbenicillin; D009070:Moxalactam