title: [Contact allergy due to halogenated corticosteroids].
abstract: Statistical evaluation of epicutaneous tests performed in 5348 patients during the years 1976 to 1980 revealed positive reactions towards topical steroids in nine cases. Three patients showed an allergy due to Dermoxin (Dermovate). Further tests with the single components of the steroidal cream disclosed a specific hypersensitivity towards clobetasol-17-propionate in two cases, towards the preservative 4-chlor-m-kresol in the third case. Cross-reactions to other fluorinated corticosteroids were not obtained. Experimental sensitisation with clobetasol-17-propionate in guinea pigs remained negative although different methods have been employed.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002990:Clobetasol / Q000009:adverse effects / Q000031:analogs & derivatives; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments
chemical_list: D000305:Adrenal Cortex Hormones; D009824:Ointments; D002990:Clobetasol
vernacular_title: Kontaktallergie durch halogenierte Kortikosteroide.