Transduction of effector-suppressor T cells by an antigen-specific suppressor T cell factor and Lyt-1+,2+,3+ T cells.
The cellular consequences in the suppression of IgG antibody formation initiated by an antigen-specific suppressor T cell factor (TsF) were investigated. The initial step of the suppression is the production of TsF by Lyt-2+,3+ T cells (Tsi) which activates Lyt-1+,2+,3+ acceptor T cells in the nylon wool-adherent T cell population. The activated Lyt-1+,2+,3+ T cells further generate a new effector-suppressor T cell ( Tse ) that belongs to the Lyt-2+,3+ T cell subset in the culture of nylon-adherent T cells with antigen. The Tse thus induced directly suppresses the responses mounted by B cells and nylon column-purified helper T cells in the absence of TsF. The origin of Tse was further examined by utilizing Lyt congeneic mice. The result indicates that Lyt-1+,2+,3+ acceptor T cells themselves do not differentiate into Lyt-2+,3+ Tse with losing Lyt-1 phenotype but facilitate the transduction of Tse from a preexisting precursor pool. These cellular interactions strongly suggest that Lyt-1+,2+,3+ T cells play a decisive role in an amplification of immunoregulation.
D000818:Animals; D000917:Antibody Formation; D000950:Antigens, Ly / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology; D008222:Lymphokines / Q000276:immunology; D051379:Mice; D011971:Receptors, Immunologic / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000950:Antigens, Ly; D008222:Lymphokines; D011971:Receptors, Immunologic