Severe vascular spasm due to erythromycin-ergotamine interaction.
We report a case of ergotism due to the interaction of erythromycin with a small dose of ergotamine tartrate (2 mg). Besides severe peripheral vasospasm with dysaesthesiae there was transient renal ischaemia. Recovery occurred after several weeks without sodium nitroprusside therapy. Cases previously reported in the literature are reviewed.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000328:Adult; D004357:Drug Synergism; D004878:Ergotamine; D004879:Ergotamines / Q000009:adverse effects* / Q000627:therapeutic use; D004917:Erythromycin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000139:chemically induced*; D007511:Ischemia / Q000139:chemically induced; D007668:Kidney / Q000098:blood supply; D007866:Leg / Q000098:blood supply; D008881:Migraine Disorders / Q000188:drug therapy*
D004879:Ergotamines; D004917:Erythromycin; C011462:erythromycin stearate; D004878:Ergotamine