Cell cycle specific variations in transport capacity of an isolated Ca2+-transport system.
From sea urchin eggs as well as from mammalian cells a Ca2+-transporting system is described in its properties. One of its main components is the "mitotic" Ca2+-ATPase. If its activity is studied during the cell cycle of fertilized sea urchin eggs, fluctuations of the Ca2+-uptake capacity are found with a maximum in every cell cycle at mitosis. Additionally, only in the first cycle after fertilization, another activity increase occurs at the time of spermaster formation. This system, then, seems to qualify for one of the main regulators of the mitotic process.
D000818:Animals; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002453:Cell Cycle; D005260:Female; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008938:Mitosis; D010063:Ovum / Q000378:metabolism; D012617:Sea Urchins / Q000378:metabolism
D000252:Calcium-Transporting ATPases; D002118:Calcium