[Effect of phenothiazines on Ca-ATPase in the sarcoplasmic reticulum of rabbit skeletal muscles].
The phenothiazines trifluoroperazine , chlorpromazine and etmozine inhibit Ca-ATPase of the sarcoplasmic reticulum of rabbit skeletal muscles. The inhibitory action decreases in the order of trifluoroperazine greater than chlorpromazine greater than etmozine . The data are provided, indicating that the inhibitory effects of the phenothiazines on Ca-ATPase of the reticulum of the skeletal muscles are not mediated via calmodulin.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D002746:Chlorpromazine / Q000494:pharmacology; D066298:In Vitro Techniques; D016293:Moricizine; D009132:Muscles / Q000201:enzymology*; D010640:Phenothiazines / Q000494:pharmacology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000201:enzymology*; D014268:Trifluoperazine / Q000494:pharmacology
D010640:Phenothiazines; D014268:Trifluoperazine; D016293:Moricizine; D000252:Calcium-Transporting ATPases; D002746:Chlorpromazine
Vliianie fenotiazinov na Ca-ATPazu sarkoplazmaticheskogo retikuluma skeletnykh myshts krolika.