Contact dermatitis from dibutylthiourea. Report of a case with fine structural observations of epicutaneous testing with dibutylthiourea.
A 35-year-old machinist developed hand eczema from contact allergy to dibutylthiourea, a compound found in a paint and glue remover. Light and electron microscopy of his positive patch test was consistent with allergic contact dermatitis, showing Langerhans cell-mononuclear cell contacts in the epidermis.
D000328:Adult; D001706:Biopsy; D009783:Dermatitis, Occupational / Q000473:pathology*; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010328:Patch Tests; D012867:Skin / Q000473:pathology; D012882:Skin Tests; D013890:Thiourea / Q000009:adverse effects / Q000031:analogs & derivatives*
C034546:1,3-dibutyl-2-thiourea; D013890:Thiourea