title: Gram-negative bacterial toe web infection: successful treatment with a new third generation cephalosporin.
abstract: Fifteen patients with gram-negative bacterial toe web infections were treated for 1 week with intramuscular cefoperazone, a broad-spectrum third generation cephalosporin. Initial bacterial cultures in eleven patients (73%) grew more than one gram-negative organism. Pseudomonas aeruginosa was the most frequent isolate. All bacteria isolated were sensitive to cefoperazone (Cefobid). Swelling, redness, and flow of exudate resolved within 1 week of antibiotic administration. By day 7 there was no evidence of inflammation, and denuded areas had begun to re-epithelialize. Side effects were mild and did not require cessation of therapy. This antibiotic causes rapid resolution of a disease which previously required prolonged hospitalizations.
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D002438:Cefoperazone; D002511:Cephalosporins / Q000627:therapeutic use*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011512:Proteus Infections / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000188:drug therapy; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013290:Streptococcal Infections / Q000188:drug therapy; D014034:Toes
chemical_list: D002511:Cephalosporins; D002438:Cefoperazone