[Neurochemical analysis of the mechanism of action of serotoninergic substances on avoidance behavior in situations of acute stress].
The mechanism of action of 5-hydroxytryptophan (5-HT, 10 mg/kg), quipazin (7 mg/kg), zimelidin (15 mg/kg) and m-chlorophenylpiperazine (5 mg/kg) was examined with the aid of some analyzer substances. The avoidance behavior under stress was used as criterion of estimation. The optimizing effect of 5-HT on the avoidance behavior was demonstrated to be a consequence of serotonin synthesis activation and its release with activation of postsynaptic 5-HT-1-receptors. An adverse effect of quipazin on the avoidance behavior was, to a greater degree, due to the activation of 5-HT-2-autoreceptors rather than of dopamine receptors. The inhibitory effect of m- chlorphenylpiperazine was reversed by administration of pyrenepyrone , a blocker of 5-HT-2-receptors. The inhibitory effect of zimelidine on the avoidance behavior was not removed by clonidin . The positive effect on the avoidance behavior under stress occurs as a result of exposures that activate the synthesis and release of 5-HT as well as of activation of postsynaptic 5-HT-1 receptors.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000208:Acute Disease; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003533:Cyproheptadine; D006801:Humans; D006834:Hydrazines; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010880:Piperidines; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000523:psychology*; D014149:Tranquilizing Agents; D015031:Zimeldine / Q000494:pharmacology*
D006834:Hydrazines; D010879:Piperazines; D010880:Piperidines; D011804:Quinolines; D014149:Tranquilizing Agents; D003533:Cyproheptadine; D015031:Zimeldine; D011814:Quipazine; C004297:3-hydroxybenzylhydrazine; D006916:5-Hydroxytryptophan; C015068:1-(3-chlorophenyl)piperazine; C034177:pirenperone
Neĭrokhimicheskiĭ analiz mekhanizma deĭstviia serotoninergicheskikh veshchestv na povedenie izbavleniia v situatsii ostrogo stressovogo vozdeĭstviia.