[Action of hepatic chalones on the proliferation of hepatocytes from intact and denervated livers].
The paper is concerned with the action of chalones, tissue-specific inhibitors of cell proliferation, on DNA synthesis and mitotic activity of hepatocytes in the intact and denervated liver during regeneration. Experiments were made on Wistar rats. Liver denervation was performed by bilateral subdiaphragmal vagotomy. In control and vagotomized animals, two thirds of the liver was resected. The data obtained indicate that chalones noticeably reduce the number of DNA-synthesizing cells and mitoses in the regenerating liver of intact animals. During regeneration of the denervated liver, chalones do not produce any inhibitory action on the intensity of proliferation. Analysis of the data obtained allows a conclusion that preservation of adequate innervation of the organ is needed for realization of the action of hepatic chalones.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D003714:Denervation; D006131:Growth Inhibitors / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000294:innervation; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D006131:Growth Inhibitors; D004247:DNA
Deĭstvie pechenochnykh keĭlonov na proliferatsiiu gepatotsitov intaktnoĭ i denervirovannoĭ pecheni.