[Search for and study of antiarrhythmic substances among crown ethers].
The authors studied antiarrhythmic properties of macrocyclic polyesters. Some of the esters exhibited antiarrhythmic activity coupled with low toxicity. It was found that antiarrhythmic action of these substances is not mediated via acetylcholine and/or catecholamine system responsible for nervous regulation of the cardiac activity. The compounds under study were found to have marked antifibrillar properties. Experiments on an isolated rat heart demonstrated calcium specificity of the antifibrillar action of cyclolactones. It is assumed that macrocyclic polyesters represent a new class of antiarrhythmic agents having a direct cardiotropic action.
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D002122:Calcium Chloride; D004353:Drug Evaluation, Preclinical; D004988:Ethers, Cyclic / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D051381:Rats; D013328:Strophanthins; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D004988:Ethers, Cyclic; D013328:Strophanthins; D002122:Calcium Chloride; D000157:Aconitine
Poisk i izuchenie antiaritmicheskikh veshchestv v riadu kraun-éfirov.