Nuclear membrane indentations in Huntington's chorea.
Electron-microscopical examination of the nucleus accumbens, caudate nucleus and frontal cortex was performed in 21 patients with Huntington's disease (HD) and 21 age-matched controls. In HD, nuclear membrane indentations (NMI) were found in 25%, 29% and 20%, respectively, of the neurons of these areas. In the control group these figures were 4%, 4% and 38%, respectively. Possible pathogenetic mechanisms of the NMI are discussed.
D000328:Adult; D000368:Aged; D001921:Brain / Q000648:ultrastructure*; D002421:Caudate Nucleus / Q000648:ultrastructure; D002452:Cell Count; D005260:Female; D005625:Frontal Lobe / Q000648:ultrastructure; D006801:Humans; D006816:Huntington Disease / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology; D009683:Nuclear Medicine; D009714:Nucleus Accumbens / Q000648:ultrastructure