title: High-frequency ventilation lengthens expiration in the anesthetized dog.
abstract: We tested the response of nine barbiturate-anesthetized dogs to high-frequency ventilation (HFV) (40-55 ml tidal volumes at 15 Hz) while measuring and controlling lung volume and blood gases. When lung volume and PCO2 were held constant, six of the nine responded to HFV by lengthening expiration. In each of these six dogs the maximal response was apnea. The response was immediate. In submaximal responses only expiration was changed; inspiratory time and peak diaphragmatic electrical activity were unaffected. There was a variable effect on abdominal muscle activity. If mean expiratory lung volume was allowed to increase at the onset of HFV, the Hering-Breuer inflation reflex added to the response. The strength of the response depended on level of anesthesia and arterial PO2. Vagotomy abolished the response in all cases. We conclude that oscillation of the respiratory system reflexly prolongs expiration via mechanoreceptors, perhaps those in the lungs.
mesh_terms: D000009:Abdominal Muscles / Q000502:physiology; D000768:Anesthesia, General; D000818:Animals; D004285:Dogs; D005260:Female; D008297:Male; D011175:Positive-Pressure Respiration; D012119:Respiration; D013997:Time Factors; D014628:Vagotomy