The cardiac atrioventricular conduction system in familial amyloidosis with polyneuropathy. A clinico-pathologic study of six cases from Northern Sweden.
Cardiac conduction disturbances are frequent in amyloidosis with cardiac involvement, but the pathogenesis of these electrocardiographic abnormalities is not clear. In the present study, the conduction systems in six patients with the Swedish variety of familial amyloidosis with polyneuropathy (FAP), have been analyzed. The results suggest that in FAP, direct amyloid infiltration of the atrioventricular conduction system accounts for the majority of the electrocardiographic disturbances.
D000219:Adams-Stokes Syndrome / Q000150:complications; D000328:Adult; D000368:Aged; D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications / Q000235:genetics / Q000473:pathology*; D001283:Atrioventricular Node / Q000032:analysis / Q000473:pathology*; D006332:Cardiomegaly / Q000150:complications; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D006329:Heart Conduction System / Q000473:pathology*; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000150:complications / Q000235:genetics / Q000473:pathology*; D006801:Humans; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000473:pathology
D000682:Amyloid