[Molecular mechanisms of the effect of neurogenic dystrophy of the kidneys in the rat on the sensitivity of the organ to aldosterone].
The effect of reflex and denervated dystrophy of the rat kidneys on the interaction of aldosterone-3H with specific cytoplasmic receptors and nuclei of this organ was investigated in vitro and in vivo experiments. It was found that reflex dystrophy decreases the intensity of hormone binding with cytoplasmic receptors by 36% and aldosterone-3H accumulation in the renal nuclei by 51%. The influence of denervated dystrophy of the organ specific hormone accumulation in the same subcellular fractions was not observed. The more accurate data on the effect of renal reflex dystrophy on aldosterone-3H-receptor interaction were obtained in vivo experiments comparatively to those in vitro.
D000450:Aldosterone / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D003714:Denervation; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism; D018161:Receptors, Mineralocorticoid; D012018:Reflex / Q000502:physiology
D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone
Molekuliarnye mekhanizmy vliianiia neĭrogennoĭ distrofii pochek krys na chuvstvitel'nost' organa k al'dosteronu.