Malignant lymphocytic lymphoma. Demonstration of a serum inhibitor of myelopoiesis and response to combination chemotherapy.
A case of diffuse well differentiated lymphocytic lymphoma with associated leukopenia, is described. The colony-forming unit (CFU-C) assay was used to quantitate myeloid precursor cells and to test for the presence of suppressor cells and/or serum factors inhibiting myeloid cell proliferation. Mild suppression of CFU-C was noted with the patient's bone marrow cells in coculture studies with normal marrow. The patient's serum, when added to the culture of normal bone marrow cells, produced a marked decrease in CFU-C. Treatment with combination chemotherapy (prednisone, cyclophosphamide, and vincristine) produced a clinical response with correction of the leukopenia. Post-treatment serum did not produce a significant reduction in CFU-C from normal bone marrow.
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006410:Hematopoiesis; D006801:Humans; D007970:Leukopenia / Q000150:complications; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone