title: A comparison between the physiological and histochemical characterisation of urethral striated muscle in the guinea pig.
abstract: In this in vitro study comparison has been made between the actomyosin ATPase activity and the contractile properties of the external urethral sphincter in the guinea pig. Histochemical analysis showed the external urethral sphincter to contain a mixture of alkali and acid stable actomyosin ATPase positive fibres in the ratio of 3:1. External urethral sphincter isometric contraction measurements were undertaken using specimens mounted transversely or longitudinally with respect to the urethral lumen. These contraction parameters have shown that the majority of fibres which constitute the external urethral sphincter correspond to the fast twitch type. In order to determine whether the relatively small fibre diameter of urethral striated muscle influenced the contraction results, when compared with controls, corrections for different volume ratios of slow and fast fibres were applied to the results. These modified values revealed close correlation between muscle fibre actomyosin ATPase content and isometric contraction responses.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D005260:Female; D006168:Guinea Pigs / Q000378:metabolism / Q000502:physiology*; D006651:Histocytochemistry; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000201:enzymology / Q000502:physiology*; D014521:Urethra / Q000201:enzymology / Q000502:physiology*
chemical_list: D000251:Adenosine Triphosphatases