Lyb3: a B cell surface antigen associated with triggering secretory differentiation.
The results discussed in this review show that the TNP-specific IgA lambda 2-secreting BALB/c plasmacytoma MOPC-315 is partially composed of small lymphocytoid, presecretory cells which express the Lyb3 determinant. It is shown that MOPC-315 cell secretory differentiation, but not clonal proliferation, can be modulated by anti-Lyb3. Anti-Lyb3 serum has been shown to: 1) augment secretory differentiation enhancement by suboptimal numbers of secretory differentiation-enhancing, IgA315-specific helper T cells; 2) replace this secretory differentiation-enhancing T cell population as long as clone growth helper T cells are present; and 3) block suppression of secretory differentiation mediated by carrier-immune Ts cells. These results demonstrate that whether anti-Lyb3 serum enhances immune responses by replacing or augmenting a helper signal or by counteracting suppressor signals, the effects are focused on secretory differentiation events and have no effect on clonal proliferation.
D000911:Antibodies, Monoclonal; D000950:Antigens, Ly / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D007136:Immunoglobulins / Q000378:metabolism; D008211:Lymphocyte Cooperation; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000911:Antibodies, Monoclonal; D000950:Antigens, Ly; D007136:Immunoglobulins