[Neuro-endocrine effects of chronic clonidine administration in rats].
Neuroendocrine effects of chronic clonidine administration - which has been proposed as antimanic drug - have been evaluated in the female rat for a twenty one days period at the following doses : 0,5 ; 5 ; 25 and 50 micrograms.kg-1.day-1. No modification of the evolution of the oestrus cycle was observed, whereas pituitary hormones (PRL, FSH and LH) plasma levels were not statistically modified. The results of this study are opposed to those frequently observed with classical neuroleptic drugs.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004031:Diestrus / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003000:Clonidine
Etude des effets neuro-endocriniens de l'administration chronique de clonidine chez la ratte.