Low dose prednisolone or oestrogen in the treatment of women with late onset or persistent acne vulgaris.
Women with persistent or late onset acne vulgaris were divided into two treatment groups. The first received continuous low dose prednisolone to suppress ACTH-dependent androgen secretion and the second was treated with cyclical oestrogens with medroxyprogesterone to elevate sex hormone binding globulin (SHBG). In both groups there was a significant improvement in the severity of the acne after 4 months' treatment. Although pre-existing hormonal abnormalities were corrected, the improvement in the acne did not correlate with the baseline hormone levels. However, suitable oestrogen-progesterone combinations or low dose prednisolone may be given, alone or in combination, to suppress free circulating androgens in these patients with a high probability of improving their acne.
D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy*; D000728:Androgens / Q000097:blood; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D017258:Medroxyprogesterone Acetate; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D000728:Androgens; D012738:Sex Hormone-Binding Globulin; D004997:Ethinyl Estradiol; D011239:Prednisolone; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone