Monocyte/T-cell interactions in Con A induced suppressor activity.
It is well documented that peripheral blood mononuclear cells (PBMC) can exert a Con A induced suppressor activity. The PBMC content of monocytes and its impact on registered suppressor activity of PBMC populations was examined. It was found that monocytes were unnecessary for the Con A induction of PBMC, and monocytes exhibited no Con A dependent suppressor potential. Furthermore, the presence of monocytes was found to be unnecessary for the Con A activated lymphocytes in order to exert their suppressor activity against the responder system, i.e. a Con A stimulated lymphoblast-transformation.
D003208:Concanavalin A / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation; D009000:Monocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D003208:Concanavalin A