Involvement of liver aldehyde oxidase in the reduction of nicotinamide N-oxide.
The present paper describes that mammalian liver aldehyde oxidase is involved in the reduction of nicotinamide N-oxide to nicotinamide. Rabbit liver aldehyde oxidase supplemented with its electron donor exhibited a significant nicotinamide N-oxide reductase activity under anaerobic conditions. Liver cytosols from rabbits, hogs, guinea pigs, hamsters, rats and mice, all of them, similarly exhibited the N-oxide reductase activity in the presence of an electron donor of aldehyde oxidase, but not xanthine oxidase. The cytosolic N-oxide reductase activity was almost completely inhibited by menadione, an inhibitor of aldehyde oxidase.
D042931:Aldehyde Oxidase; D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000693:Anaerobiosis; D000818:Animals; D006224:Cricetinae; D003600:Cytosol / Q000201:enzymology; D006168:Guinea Pigs; D008099:Liver / Q000201:enzymology*; D051379:Mice; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000378:metabolism; D010084:Oxidation-Reduction; D011743:Pyrimidines / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013552:Swine; D014812:Vitamin K / Q000494:pharmacology
D011743:Pyrimidines; D014812:Vitamin K; D009536:Niacinamide; C041345:2-hydroxypyrimidine; C037645:nicotinamide N-oxide; D000445:Aldehyde Oxidoreductases; D042931:Aldehyde Oxidase