The effect of ribavirin and rifamycin SV on age-dependent changes of the immune system during the adult life of SJL mice.
Ribavirin and Rifamycin SV, given from birth to adult life, arrest the loss of suppressor capacity, normally occurring in older SJL mice. The two drugs differ in their effect on Th-2-type help for the indirect plaque-forming response, i.e. for help which is independent of the carrier-hapten bridge. This type of help normally increases with age. Ribavirin treatment inhibits development of Th-2-type of help; Rifamycin SV does not interfere with the development of this type of help. Neither of the two drugs had an effect on the ability of SJL mice, not treated with aggregate-freed RGG, to make a plaque-forming response to aggregated RGG.
D000375:Aging; D000818:Animals; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects; D007109:Immunity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012254:Ribavirin / Q000008:administration & dosage / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D012294:Rifamycins / Q000008:administration & dosage / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D012263:Ribonucleosides; D012294:Rifamycins; D012254:Ribavirin; C023808:rifamycin SV