title: Plasma levels of dehydroepiandrosterone and 17 beta-estradiol after intramuscular administration of Gynodian-Depot in 3 women.
abstract: Gynodian-Depot is well suited for treatment of the characteristic symptoms accompanying the menopause in women. The plasma levels of prasterone and 17 beta-estradiol after intramuscular injection of Gynodian-Depot in women were studied using a radioimmunological method. The maximum active ingredient concentrations were found in the plasma of the subjects only a few days after administration. The depot action lasted on an average 14 days (17 beta-estradiol) and 18 days (prasterone) after administration, respectively. Prasterone enanthate is completely hydrolysed into the free steroid and the fatty acid.
mesh_terms: D000328:Adult; D001682:Biological Availability; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism; D003692:Delayed-Action Preparations; D004338:Drug Combinations / Q000378:metabolism; D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D003692:Delayed-Action Preparations; D004338:Drug Combinations; D003687:Dehydroepiandrosterone; D004958:Estradiol; C033625:Gynodian