Inhibition by dicyclohexylcarbodiimide of ATP synthesis in isolated rat hepatocytes.
Dicyclohexylcarbodiimide (DCCD) inhibits, by 50%, ATP synthesis in isolated hepatocytes. This inhibition is associated with DCCD-binding to a proteolipid fraction present in submitochondrial particles.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D002234:Carbodiimides / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D002352:Carrier Proteins / Q000378:metabolism; D004024:Dicyclohexylcarbodiimide / Q000378:metabolism / Q000494:pharmacology*; D006593:Hexokinase / Q000378:metabolism; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D051381:Rats; D013367:Submitochondrial Particles / Q000378:metabolism
D002234:Carbodiimides; D002250:Carbon Radioisotopes; D002352:Carrier Proteins; D004024:Dicyclohexylcarbodiimide; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D000251:Adenosine Triphosphatases