[Neonatal syphilis despite erythromycin treatment of the mother].
A one-month old infant whose mother had been treated with erythromycin during pregnancy exhibited signs of severe congenital syphilis with collapse requiring admission to an intensive care unit. Erythromycin has low placental transfer and other treatments would have probably been more adequate. Some authors advocate the use of the latest tetracyclines and doxycycline could also be administered. The WHO's recommendations that all children born of mothers who were not treated with penicillin should receive this antibiotic after birth is still valid.
D004917:Erythromycin / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D010406:Penicillins / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D013587:Syphilis / Q000188:drug therapy*; D013590:Syphilis, Congenital / Q000209:etiology* / Q000517:prevention & control; D013754:Tetracyclines / Q000627:therapeutic use
D010406:Penicillins; D013754:Tetracyclines; D004917:Erythromycin
Syphilis néo-natale malgré le traitement de la mére par l'érythromycine.