title: Lymphocyte studies in rheumatoid arthritis. V. Suppressor cell function in peripheral blood.
abstract: Peripheral blood lymphocytes from 30 patients with rheumatoid arthritis and 14 controls were examined for suppressor activity by two different assays. These were the Concanavalin-A-induced and the short-lived suppressor cell assays. There was no difference in suppressor activity between patients and controls, the suppressor activity of HLA-DR3 positive patients was no less than that of non-DR3 patients. However, patients with nodules showed reduced suppression in the short-lived suppressor cell assay when compared with patients without nodules.
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D003208:Concanavalin A / Q000276:immunology; D005260:Female; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D003208:Concanavalin A