Selective action of D-penicillamine on guinea pig peritoneal macrophage Fc gamma receptors for homologous, monomeric IgG1.
Guinea pig oil-induced peritoneal exudates were pretreated with D-penicillamine. The binding of homologous, monomeric IgG2 and IgG1 to normal and pretreated exudates was examined. Whereas the 7S IgG2-IgG2 Fc gamma receptor interaction remains unaffected by the pretreatment, the binding of IgG1 to the IgG Fc gamma receptor population was affected. The significance of the selective effect of D-penicillamine is discussed.
D000818:Animals; D001667:Binding, Competitive; D002478:Cells, Cultured; D006168:Guinea Pigs; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G / Q000378:metabolism; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism*; D010396:Penicillamine / Q000494:pharmacology*; D011961:Receptors, Fc / Q000187:drug effects*; D017452:Receptors, IgG
D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D011961:Receptors, Fc; D017452:Receptors, IgG; D010396:Penicillamine