Testicular damage and change in serum LDH isozyme pattern induced by multiple sub-lethal doses of apholate in albino rats.
Treatment with apholate caused degenerative changes in the testes of albino rats. No histological changes were observed in Leydig cells. LDH-X activity was present in the serum of treated rats and absent in controls. Electrophoresis indicates that the activity band present in serum was similar to the activity band found in testes. A colorimetric method for assaying LDH-X activity is reported.
D000818:Animals; D001388:Aziridines / Q000633:toxicity*; D001389:Azirines / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D003124:Colorimetry; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013733:Testicular Diseases / Q000139:chemically induced*; D013737:Testis / Q000032:analysis
D001388:Aziridines; D001389:Azirines; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase