title: [Comparative studies on the toxicity of various dielectrics--petroleum derivatives used in the electroerosion technic. V. Functional, morphological and cytoenzymatic changes in the kidneys of rats chronically exposed to petroleum hydrocarbons].
abstract: The rats exposed for 14 weeks to odourless kerosene mists (concentration of 75 and 300 mg/m3) had their urinary chemical and morphotic composition determined. In addition, morphological and cytoenzymatic examinations of kidneys were carried out. The findings were: increased pH and protein concentration and single erythrocytes in urine and also: passive congestion of renal cortex and medulla, infiltrates composed of granulocytes and eosinophils and albuminous casts in renal tubules. Decreased activity of succinate dehydrogenase, glucoso-6-phosphatase, Mg++ stimulated adenosinotriphosphatase and increased activity of acid phosphatase were found. Those changes were localized in cortical part of the kidney especially in the main tubules epithelial cells. The observed functional, morphological and cytoenzymatic changes depended on the magnitude of exposure. The obtained results confirm that kerosene hydrocarbons may exhibit toxic effects on the kidney function and structure.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000172:deficiency; D000393:Air Pollutants / Q000633:toxicity*; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004231:Diuresis; D005954:Glucosephosphate Dehydrogenase; D005955:Glucosephosphate Dehydrogenase Deficiency; D006940:Hyperemia / Q000139:chemically induced; D007648:Kerosene / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009246:NADH Tetrazolium Reductase / Q000172:deficiency; D010578:Petroleum / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000172:deficiency; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D007648:Kerosene; D010578:Petroleum; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D009246:NADH Tetrazolium Reductase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases
vernacular_title: Porównawcze badania nad toksycznościa niektórych dielektryków pochodnych ropy naftowej stosowanych w obróbce elektroerozyjnej. V. Zmiany czynnościowe, morfologiczne i cytoenzymatyczne w nerkach szczurów przewlekle eksponowanych na weglowodory nafty.