The effect of low doses of d-amphetamine on drug-induced hyperactivity in the mouse.
The effect of low doses (7.5-250 micrograms/kg) of d-amphetamine was studied on benztropine- or gamma-butyrolactone-induced hyperactivity in the mouse. Amphetamine 30-125 micrograms/kg significantly attenuated the drug-induced hyperactivity. This effect was antagonised by both cinanserin and p-chlorophenylalanine. The results suggest that low doses of d-amphetamine release 5-hydroxytryptamine, which in turn has an inhibitory effect on locomotor activity. This effect was masked at higher doses of d-amphetamine due to a release of dopamine.
D015107:4-Butyrolactone / Q000494:pharmacology; D000818:Animals; D001590:Benztropine / Q000494:pharmacology; D002928:Cinanserin / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology*; D004347:Drug Interactions; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D001590:Benztropine; D002928:Cinanserin; D015107:4-Butyrolactone; D010134:Fenclonine; D003913:Dextroamphetamine