Animals in aging research: requirements, pitfalls and a challenge for the laboratory animal specialist.
The prime goal of aging research is to gain some insight into the basic mechanisms underlying the aging process. The long lifespan and frequent mobility of humans as well as the legal and ethical constraints on human experimentation make man unsuitable for studying the aging process. Therefore animals, particularly rodents, are used in aging research. In studying the aging process in animals, one hopes to find means for the prevention or amelioration of at least some of the disabilities of old age in man. Many intrinsic and extrinsic factors can influence the outcome of animal experiments; hence an extensive monitoring program is a prerequisite in aging research. An important role in controlling the quality of the animals is reserved for the laboratory animal specialist. Since he is faced with all aspects of laboratory animal science, aging research is a challenging area for such a specialist.
D000375:Aging; D000818:Animals; D000830:Animals, Laboratory / Q000235:genetics / Q000502:physiology*; D006224:Cricetinae; D004032:Diet; D006799:Housing, Animal; D051379:Mice; D008954:Models, Biological; D051381:Rats; D012106:Research; D012107:Research Design; D012377:Rodentia / Q000235:genetics / Q000502:physiology*; D013047:Specific Pathogen-Free Organisms