Synovial T lymphocytes in rheumatoid arthritis.
The presence of interleukin-2 (IL-2) like activity has been demonstrated in synovial fluids from rheumatoid arthritis patients. Continuous T cell lines (CTL) generated from such fluids respond to the synovial IL-2, exhibit a predominant suppressor/cytotoxic cell phenotype and release immunoregulatory mediators.
D001172:Arthritis, Rheumatoid / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology; D013582:Synovial Fluid / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007376:Interleukin-2