title: Circulating lymphocyte populations in Hodgkin's disease after mantle and paraaortic irradiation.
abstract: The effect of mantle and paraaortic radiation on peripheral blood lymphocytes was studied in 11 previously untreated patients with early stage Hodgkin's disease using a series of monoclonal antibodies defining immunoregulatory lymphoid cells. Immediately following the completion of radiotherapy, there was a significant reduction in the number of lymphocytes and the percent of circulating T cells. This acute decrease in T cells was due to a marked diminution in the number of inducer T cells, while the fraction of suppressor T cells remained constant. These changes persisted for up to 12 mo and were accompanied by a later increase in the fraction of circulating B lymphocytes and cells bearing surface Ia. It thus appears that mantle and paraaortic radiotherapy causes a relatively selective reduction in the inducer T-cell population. The implications of a change in the ratio of inducer to suppressor T cells is discussed.
mesh_terms: D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001011:Aorta / Q000528:radiation effects; D001402:B-Lymphocytes / Q000276:immunology; D006689:Hodgkin Disease / Q000097:blood* / Q000532:radiotherapy; D006801:Humans; D013154:Spleen / Q000528:radiation effects; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal