In vitro growth promotion in human malignant melanoma cells by fibroblast growth factor.
Bovine pituitary fibroblast growth factor (FGF) stimulates the incorporation of [3H]thymidine into DNA in serum-depleted cultures of some but not other human melanoma cells. The melanotic malignant melanoma cell line MIRW exhibited a 40% increase in [3H]thymidine incorporation into DNA and a 48% increase in cell number in response to 3.73 x 10(-9) M FGF. This same concentration of FGF produced a 22% increase in [3H]thymidine incorporation in the melanotic melanoma cell line Hs0294. However, FGF had no effect on the amelanotic melanoma cell line Hs0675, early-passage cultures of a human amelanotic melanoma (W-1), or early-passage cultures of a congenital nevus (N-1).
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005346:Fibroblast Growth Factors; D006801:Humans; D007700:Kinetics; D008545:Melanoma / Q000473:pathology / Q000503:physiopathology*; D008934:Mitogens / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*
D004273:DNA, Neoplasm; D008934:Mitogens; D010455:Peptides; D005346:Fibroblast Growth Factors