Substrate specificity of the erythrocyte Ca2+-ATPase.
In the absence of Mg2+, the observed activity of the erythrocyte plasma membrane Ca2+-ATPase is due to the hydrolysis of CaATP at a low rate. In the presence of Mg2+, the activity of the enzyme is much higher, but it is inhibited by high levels of free Mg2+. This inhibition appears to be due to competition of Mg2+ and Ca2+ for a site on the enzyme, rather than for ATP.
D001665:Binding Sites; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000097:blood*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D008274:Magnesium / Q000097:blood / Q000494:pharmacology; D013379:Substrate Specificity
D000252:Calcium-Transporting ATPases; D008274:Magnesium