Inflammation caused by intracutaneous implantation of stratum corneum.
When an epidermoid cyst ruptures, a granulomatous infiltrate develops around the damaged structure. The same is true when other horn-containing cysts release their content into the epidermis. A similar type of inflammation may be observed in the dermis around disrupted and horn-filled follicles in acne vulgaris. In this paper we describe experiments in which a granulomatous inflammation has been produced in guinea-pig skin by the intracutaneous implantation of stratum corneum and discuss the potential of this system as a model for the inflammation in acne.
D000152:Acne Vulgaris / Q000473:pathology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003872:Dermatitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006168:Guinea Pigs; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D011422:Propionates / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation
D000893:Anti-Inflammatory Agents; D011422:Propionates; C011677:benoxaprofen; D011239:Prednisolone