Anti-idiotype regulation of timothy grass pollen IgE antibody formation. I. In vivo induction of suppressor T cells.
Antibodies prepared against antigen B-specific T-helper factor (anti-THF) and antigen B-specific IgE (anti-IgEid) have been isolated and the anti-idiotypic properties of both antibodies were described previously. Both anti-idiotypic antibodies (anti-Id) were used to determine their influence in primary and secondary IgE responses. These studies demonstrated that both anti-Id specifically suppress timothy IgE responses, that the suppression lasts for at least 35 days, and that it is mediated by a Thy 1+ Lyt 1- 23+ T cell. Attempts to induce suppressor T cells with the F(ab)2 fragment of anti-THF at several concentrations (10-80 micrograms per day for 3 successive days) were unsuccessful. This suggests that the Fc portion may be important in presentation of anti-Id during the induction of suppressor T cells.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011058:Pollen / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007140:Immunoglobulin Fab Fragments; D007130:Immunoglobulin Idiotypes; C026408:anti-IgE antibodies; D007073:Immunoglobulin E