Sister-chromatid exchanges and cell-cycle delay in Chinese hamster V79 cells treated with 9 organophosphorus compounds (8 pesticides and 1 defoliant).
Significant increase of sister-chromatid exchanges (SCE) in V79 cells treated with 2 organophosphorus pesticides (OPP), fenthion and oxydemeton-methyl, was observed. The other 7 compounds (6 OPP and 1 defoliant) namely, amaze, azinphos-methyl, bolstar, DEF-defoliant, fensulfothion, monitor and nemacur caused no increase of SCE frequencies at the doses tested. All the compounds except fensulfothion and oxydemeton-methyl induced cell-cycle delay in varying degrees. Cell-cycle delay caused by an OPP was found to be dose-dependent. Based on these data as well as others reported, it would appear that OPP which induce no SCE increase and no or slight cell-cycle delay could be considered as good candidates to substitute the pesticides that have been found to be harmful to the environment.
D000818:Animals; D001387:Azinphosmethyl / Q000494:pharmacology; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D005284:Fenthion / Q000494:pharmacology*; D006540:Herbicides / Q000494:pharmacology; D007306:Insecticides / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D063086:Organothiophosphates / Q000494:pharmacology; D009946:Organothiophosphorus Compounds / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D006540:Herbicides; D007306:Insecticides; D009943:Organophosphorus Compounds; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; C035019:isofenphos; D001387:Azinphosmethyl; C006863:butyl phosphorotrithioate; C014655:methamidophos; C026086:methyl demeton; D005284:Fenthion; C011606:sulprofos; C002698:fenamiphos