[Antilipolytic activity in vitro of various analogs of nicotinic acid. Structure-activity relationship].
The antilipolytic activity of a series of N aryl-nicotinamides and of alpha picolinic acid, has been tested in vitro. Lipolysis was stimulated by epinephrine (20 micrograms/ml of incubation medium) using rat's epididymal adipose tissue slices. Only N(2-carboxy methyl phenyl) nicotinamide showed antilipolytic effect comparable to that of nicotinic acid at similar concentrations (2 X 10(-5) M). Picolinic acid (10(-4) M) showed no antilipolytic effect. These results, together with those of the literature, are discussed in regard to the relations between structure and antilipolytic activity.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D004822:Epididymis / Q000032:analysis; D004837:Epinephrine / Q000037:antagonists & inhibitors; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005990:Glycerol / Q000032:analysis; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D005230:Fatty Acids, Nonesterified; D009536:Niacinamide; D005990:Glycerol; D004837:Epinephrine
Actividad antilipolítica, in vitro, de diversos análogos del ácido nicotínico. Relaciones estructura-actividad.