[Effect on helper activity of synthetic polyelectrolytes introduced into an in vitro system of interacting macrophages and thymus cells].
Our experiments have shown that the joint incubation of thymocytes and syngeneic macrophages in vitro for 60 minutes is accompanied by a certain increase in the helper activity of thymocytes. The presence of polyacrylic acid or the copolymer of acrylic acid and N-vinyl-pyrrolidone, containing 56 mol% of acrylic acid, in this system ensures a considerable increase in the helper activity of thymocytes, incubated jointly with marrow cells and sheep red blood cells and then transferred into a cell culture in vivo.
D000180:Acrylic Resins / Q000494:pharmacology*; D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D000071228:Polyelectrolytes; D011108:Polymers / Q000494:pharmacology*; D011205:Povidone / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000276:immunology
D000180:Acrylic Resins; D000071228:Polyelectrolytes; D011108:Polymers; D011205:Povidone; C006903:carbopol 940
Vliianie na khelpernuiu aktivnost' sinteticheskikh poliélektrolitov, vvedennykh v sistemu in vitro vzaimodeĭstvuiushchikh makrofagov i kletok timusa.