Lymphocyte-macrophage co-operation during induction of T-suppressor cell activity in rats with adjuvant arthritis.
The role of macrophages and of macrophage-lymphocyte co-operation in the induction of T-suppressor cell activity in rats with adjuvant arthritis was investigated. Macrophages from arthritic rats had no direct effect on the induction of T-suppressor cells, but, in the presence of arthritic rats' lymphocytes or supernatants from such lymphocytes, macrophages inhibited the induction of T-suppressor cell activity. Addition of indomethacin during the induction of T-suppressor cells reduced the inhibitory effects, suggesting that prostaglandins released from lymphocyte-activated macrophages might be involved in the defective induction of T-suppressor cell activity in rats with adjuvant arthritis.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D002448:Cell Adhesion; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D003208:Concanavalin A; D007213:Indomethacin