title: Studies of chemically modified honeybee venom. II. Immunogenicity and suppression of reaginic antibody formation.
abstract: Honeybee venom allergens modified by formaldehyde treatment (F), acetoacetylation (A), and coupling to polyethylene glycol (P) were studied with regard to their immunogenicity and their IgE-suppressive potential in rabbits and mice. F indiced a strong IgG response in rabbits and especially mice, but only a moderate IgE response in the mouse. Its IgE-suppressive potential in mice was comparable to that of unmodified bee venom. A induced only a weak IgG and IgE response. Its IgE-suppressive potential was greater than that of unmodified bee venom. P was nonimmunogenic and had only a marginal IgE-suppressive effect. F and A seem promising for the treatment of bee sting-allergic individuals.
mesh_terms: D000090:Acetoacetates / Q000494:pharmacology; D000818:Animals; D001514:Bee Venoms / Q000276:immunology*; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology; D007109:Immunity; D005779:Immunodiffusion; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007167:Immunotherapy; D051379:Mice; D011092:Polyethylene Glycols / Q000494:pharmacology; D011817:Rabbits; D011935:Reagins / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000090:Acetoacetates; D001514:Bee Venoms; D007074:Immunoglobulin G; D011935:Reagins; D005557:Formaldehyde; D007073:Immunoglobulin E; D011092:Polyethylene Glycols