title: [Dynamics of skin cell proliferation and differentiation and the development of epidermocyte reactivity in the process of histogenesis: the problem of chalones].
abstract: The dynamics of proliferative activity in the epidermis and dermis cells, as well as some morpho-functional indices in the skin epithelium have been studied in 17-21 days old embryos and 1, 3, 5, 8, 10 and 20 days old rats. The epidermis acquired its definitive properties by the 8th day of postnatal development whereas the skin as an organ formed by the 20th day. The epidermocytes of the developing skin responded to the damage by a distinct proliferative reaction from the 8th day on. The epidermal chalones isolated from the skin of adult animals inhibited the division of epidermocytes in 8, 10 and 20 days old animals. No effect was observed upon the injection of epidermal chalones into 1, 3 and 5 days old rats.
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006131:Growth Inhibitors / Q000494:pharmacology*; D009024:Morphogenesis / Q000187:drug effects; D051381:Rats; D012867:Skin / Q000166:cytology* / Q000196:embryology / Q000254:growth & development
chemical_list: D006131:Growth Inhibitors
vernacular_title: Dinamika proliferatsii i differentsirovki kletok kozhi i stanovlenie reaktivnosti épidermotsitov v protsesse gistogeneza: k probleme keĭlonov.