The effect of hyperprolactinemia on the diurnal variation of adrenal androgens.
Morning and evening plasma cortisol, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) were measured in ten women with hyperprolactinemia secondary to pituitary adenomas and in seven control subjects with cyclic menses and normal prolactin (PRL) levels. Plasma cortisol and DHEA-S levels were comparable in both groups. A diurnal variation for cortisol and DHEA was identified and comparable in both groups. These findings indicate that PRL may not be an important physiologic regulator of adrenal androgen secretion.
D000236:Adenoma / Q000097:blood; D000311:Adrenal Glands / Q000378:metabolism*; D000328:Adult; D000728:Androgens / Q000097:blood / Q000378:metabolism*; D002940:Circadian Rhythm; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D010911:Pituitary Neoplasms / Q000097:blood; D011388:Prolactin / Q000097:blood*
D000728:Androgens; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin; D006854:Hydrocortisone