[Effect of high-altitude hypoxia on the effectiveness of chemotherapy in tumors].
It was shown in rat experiments that high-altitude hypoxia inhibits the growth of transplantable tumors and enhances the efficacy of antitumor treatment with chemotherapeutic drugs (thiotepa for Heren's carcinoma, and cyclophosphamide for sarcoma 45). Under high-altitude conditions, the cyclophosphamide toxicity as regards blood cells was modified, manifesting in the absence of anemization and less considerable reduction in the platelet and lymphocyte counts. The animals' adaptation to high-altitude hypoxia was followed by a rise in the blood content of sulfhydryl groups and increase in cancerolytic activity of the blood serum.
D000532:Altitude Sickness / Q000503:physiopathology*; D000818:Animals; D002277:Carcinoma / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D007707:Kyrgyzstan; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013852:Thiotepa / Q000008:administration & dosage
D003520:Cyclophosphamide; D013852:Thiotepa
Vliianie vysokogornoĭ gipoksii na éffektivnost' khimioterapii opukholeĭ.