Immunologic effects of nonsteroidal anti-inflammatory drugs.
Recent studies of the immunoregulatory effects of prostaglandin and the immunomodulating actions of nonsteroidal anti-inflammatory drugs reveal that earlier reports of inhibition of prostaglandin synthesis by nonsteroidal anti-inflammatory drugs cannot alone fully explain the anti-inflammatory properties of these agents. Data defining the complex inter-relationship of prostaglandin, the immune response, and nonsteroidal anti-inflammatory drugs are reviewed, and possible mechanisms of anti-inflammatory action of these agents are considered. The effects of nonsteroidal anti-inflammatory drugs on cellular immune function and humoral immune response suggest that anti-inflammatory activity may be related to altered suppressor cell function, inhibition of monocyte collagenase release, or inhibition of neutrophil migration and activation. Further elucidation is awaited.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000276:immunology*; D000917:Antibody Formation / Q000187:drug effects; D015232:Dinoprostone; D006085:Graft Survival / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007213:Indomethacin / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D011458:Prostaglandins E / Q000494:pharmacology; D012217:Rheumatoid Factor / Q000096:biosynthesis; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011458:Prostaglandins E; D012217:Rheumatoid Factor; D015232:Dinoprostone; D007213:Indomethacin