title: [Pharmacological and toxicological studies of Amopen powder in lambs].
abstract: The oral administration of amopen pulvis (containing 5 per cent amoxicillin trihydrate) led to the rapid resorption and elimination of amoxicillin as a constituent of the drug formula. Resorption was found to depend on the development of the forestomach. In weaned lambs it was twice as low than in sucking lambs. The antibiotic was retained in bacteriostatic concentrations up to the twelfth hour in sucking lambs and up to the tenth hour in weaned lambs following the application of 0.5, resp., 0.7 g/kg mass, corresponding to the rates of 0.015 and 0.025 g/kg mass so far as amoxicillin trihydrate was concerned. Fivefold higher doses applied to lambs did not lead to essential changes in the general state, hemoglobin value, and blood picture.
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000658:Amoxicillin / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D004361:Drug Tolerance; D009536:Niacinamide / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D011208:Powders; D012256:Riboflavin / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D012756:Sheep; D013831:Thiamine / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D004338:Drug Combinations; D011208:Powders; C037356:amoxicillin, ascorbic acid, niacinamide, riboflavin, thiamine drug combination; D009536:Niacinamide; D000658:Amoxicillin; D001205:Ascorbic Acid; D012256:Riboflavin; D013831:Thiamine
vernacular_title: Niakoi farmakologichni i toksikologichni prouchvaniia na amopen-prakh pri agneta.