title: Evolutionary roots of catalysis by nicotinamide and flavins in C-H oxidoreductases and in photosynthesis.
abstract: The evolutionary information obtained from sequencing proteins and RNA's fades out completely for early periods in evolution. Information for tracing evolution even further could stem from the analysis of coenzyme mechanisms. Likewise, placing cofactors in their proper evolutionary context gives new hints concerning their actual mechanisms of catalysis.
mesh_terms: D001419:Bacteria / Q000378:metabolism; D001665:Binding Sites; D005075:Biological Evolution; D004789:Enzyme Activation; D005415:Flavins / Q000378:metabolism*; D009536:Niacinamide / Q000378:metabolism*; D000069497:Origin of Life; D010088:Oxidoreductases / Q000378:metabolism*; D010788:Photosynthesis; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D005415:Flavins; D009536:Niacinamide; D010088:Oxidoreductases; D013385:Succinate Dehydrogenase