title: [Chemonucleolysis in the treatment of sciatica caused by herniated disk].
abstract: Chemonucleolysis is an effective treatment of sciatica due to herniated lumbar disc after conservative treatments have failed. Provided the proper technique is applied and the patients are well selected (complete herniation or herniation within a narrow spinal canal being excluded), surgery can be avoided in the majority of cases. Chemonucleolysis does not in any way complicate subsequent surgery if required and post-nucleolysis surgery gives the same results as first intention surgery. The method, therefore, should not be regarded as an alternative to surgery but as the last stage of conservative treatment. Allergic reactions are the only true side-effects and require special precautions.
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced; D000818:Animals; D002917:Chymopapain / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D010450:Endopeptidases / Q000627:therapeutic use*; D006801:Humans; D007267:Injections / Q000379:methods; D007403:Intervertebral Disc / Q000000981:diagnostic imaging / Q000187:drug effects*; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011859:Radiography; D012585:Sciatica / Q000209:etiology / Q000628:therapy*
chemical_list: D010450:Endopeptidases; D002917:Chymopapain
vernacular_title: La chimionucléolyse dans le traitement des sciatiques par hernie discale.