title: Demonstration of antibodies to phosphoglucomutase of parasitic origin in Brugia pahangi-infected cats.
abstract: Antibodies inhibitory to the activity of the enzyme phosphoglucomutase (PGM) EC 2.7.5.1. of Brugia pahangi adult worm were demonstrated in sera from five rabbits immunized against this filarioid and from 5 of 27 cats infected with B. pahangi, by isoelectricfocusing and spectrophotometric techniques. This anti-PGM activity was species- and stage-specific. This raises the possibility of using species-specific isoenzymes of parasitic origin as antigens in serological tests.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis*; D002009:Brugia / Q000201:enzymology / Q000276:immunology*; D002415:Cats; D005260:Female; D005368:Filariasis / Q000276:immunology*; D005370:Filarioidea / Q000276:immunology*; D008297:Male; D010733:Phosphoglucomutase / Q000037:antagonists & inhibitors / Q000276:immunology*; D011817:Rabbits; D013045:Species Specificity
chemical_list: D000906:Antibodies; D010733:Phosphoglucomutase