Leukotriene D4 increases nasal blood flow in humans.
The effect of leukotriene D4 on the nasal mucosal blood flow in humans was measured using a laser doppler flow meter. The leukotriene solution was applied topically to the nasal mucosa in 9 healthy subjects, and changes in blood flow were measured non-traumatically by the laser doppler instrument. The response showed a consistent increase in blood flow. A dose-response was found in the range of 0.063 - 4.0 nanomole. These results confirm an earlier study on the human skin, implicating leukotriene D4 as an important vasodilator in humans. No increase in nasal secretion was noted by the subjects tested.
D000287:Administration, Topical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007834:Lasers; D009297:Nasal Mucosa / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects; D012212:Rheology; D013189:SRS-A / Q000008:administration & dosage / Q000494:pharmacology*
D013189:SRS-A