[Estimation of the effects of cardenolides. 1. Relation between molecular physical parameters and parameters of action of cardenolides].
Knowing the modell developed by Repke and co-workers for the cardenolide-receptor-interaction the aim of this study was to find quantitative relations between molecular physical properties of cardenolides and their molecular-biologically defined effect, which are fundamentally useful to estimate the effect of still nonsynthesized cardenolide derivatives. The statistically significant relations (alpha = 0.05) between molecular physical parameters, which are derived from the dipole moment vector, and the molecular-biologically defined effect was found by means of regression analysis.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D002298:Cardenolides / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008968:Molecular Conformation; D012044:Regression Analysis; D013329:Structure-Activity Relationship
D002298:Cardenolides; D000251:Adenosine Triphosphatases
Abschätzung der Wirkstärke von Cardenoliden. 1. Mitteilung: Zusammenhang zwischen molekülphysikalischen Parametern und dem Wirkstärkeparameter von Cardenoliden.