The effect of human IgM rheumatoid factor on renal glomerular immune complex deposition in passive serum sickness in the mouse.
The results of experiments reported in this paper show that intravenously injected human IgM rheumatoid factor binds in vivo to immune complexes previously deposited in mouse glomerulus. Prior injection of human IgM rheumatoid factor does not interfere with glomerular deposition of passively administered immune complexes. Evidence is presented to show that rheumatoid factor once attached to glomerular bound immune complexes is able to act as an immunoabsorbent and to bind further circulating complexes.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D007105:Immune Complex Diseases / Q000276:immunology*; D007075:Immunoglobulin M / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D008856:Microscopy, Fluorescence; D012217:Rheumatoid Factor / Q000378:metabolism*; D012710:Serum Albumin, Bovine / Q000276:immunology
D000936:Antigen-Antibody Complex; D007075:Immunoglobulin M; D012710:Serum Albumin, Bovine; D012217:Rheumatoid Factor