Ventricular hypertrophy in sinoaortic denervated rats.
Sinoaortic denervation (SAD) induced a significant increase in mean arterial pressure in male (122 +/- 3 mmHg) and female (126 +/- 3 mmHg) rats compared to male (103 +/- 2 mmHg) and female (106 +/- 3 mmHg) sham-operated (SO) controls (P less than 0.05). A significant increase of the weight of the left ventricle (LV) (11.5%, P less than 0.001) was observed 15 days after surgery in male, but not in female, SAD hypertensive rats compared to pair-fed SO controls. The data suggest that hormonal factors contribute to rapid LV hypertrophy in male SAD hypertensive rats.
D000818:Animals; D001794:Blood Pressure; D006332:Cardiomegaly / Q000209:etiology*; D003714:Denervation; D004195:Disease Models, Animal; D005260:Female; D006339:Heart Rate; D006973:Hypertension / Q000150:complications*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D012850:Sinus of Valsalva / Q000294:innervation / Q000601:surgery