Immunoreactivity of long lived H-2 incompatible irradiation chimeras (H-2d leads to H-2b).
Allogenic irradiations bone marrow chimeras made according to a new protocol with unmanipulated bone marrow are long lived, healthy and stable full chimeras (H-2d leads to H-2b). Their immunocompetence is split. Alloreactivity measured by skin graft rejection and mixed lymphocyte culture is within normal range. In contrast, major histocompatibility complex (MHC)-restricted T-cell-dependent primary responses against sheep red blood cells (SRBC) or viruses are clearly deficient. The quantitative difference in immunocompetence is at least of the order of ten-to thirty-fold. The implications of the findings for lymphohaemopoietic reconstitution of immunodeficient patients are briefly discussed.
D000818:Animals; D000917:Antibody Formation; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection; D006183:H-2 Antigens / Q000276:immunology*; D007121:Immunocompetence; D007959:Lymphocyte Culture Test, Mixed; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology; D014616:Vaccinia virus / Q000276:immunology
D006183:H-2 Antigens