ATPase-associated oligomycin resistance in Acanthamoeba castellanii.
The multiplication rate of "wild-type" (WT) populations of Acanthamoeba castellanii was inhibited 50% by approximately 3 microgram oligomycin/ml; OliR2, an oligomycin resistant cell line, required approximately 27 microgram/ml for the same inhibition. ATPase solubilized from OliR2 mitochondrial fractions required 3--10-fold higher concentrations of oligomycin than did identical WT fractions to achieve 50% inhibition of activity. Resistance was correlated with altered mitochondrial ATPase sensitivity to oligomycin.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000656:Amoeba / Q000187:drug effects* / Q000201:enzymology; D004351:Drug Resistance; D008928:Mitochondria / Q000201:enzymology; D009840:Oligomycins / Q000494:pharmacology*
D009840:Oligomycins; D000251:Adenosine Triphosphatases