Helper cells in the autologous mixed lymphocyte reaction (AMLR). IV. H-2 restriction and specificity of cytotoxic cells induced by AMLR helper factor.
Supernatants from Day 3 cultures of T cells stimulated with syngeneic non-T cells in the autologous mixed lymphocyte reaction (AMLR) contained a T-cell factor distinct from interleukin 2 (IL-2). The AMLR factor could mediate the cytotoxic response of T cells to hapten-modified nonstimulatory syngeneic cells. The activity of this helper factor was H-2 unrestricted. However, the cytotoxic cells which developed in the presence of this factor were H-2 restricted and hapten specific.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000276:immunology*; D006241:Haptens; D008211:Lymphocyte Cooperation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008815:Mice, Inbred Strains; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D006183:H-2 Antigens; D006241:Haptens