TSH stimulation of iodine organification in early foetal rat thyroid in vitro.
Thyroid glands from 15 day-old rat foetuses were incubated in Eagle's medium containing Na 125I and supplemented, or not, with TSH for 4 or 24 hours. Electron microscopic radioautographic study shows silver grains mainly in follicular cavities only in the thyroids submitted to TSH during 24 hr. A functional differentiation must therefore take place in thyroid cells under TSH stimulation.
D000818:Animals; D005260:Female; D007455:Iodine / Q000378:metabolism*; D009924:Organ Culture Techniques; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism; D013972:Thyrotropin / Q000494:pharmacology*
D013963:Thyroid Hormones; D013972:Thyrotropin; D007455:Iodine