title: [2-Aminopurine, analog of adenine, induces a nonmutagenic repair mechanism acting upon UV lesions of double-stranded DNA in E. coli].
abstract: The survival of ultraviolet light (UV)--irradiated lambda phage is increased when host bacteria are grown in the presence of the base analogue 2-amino-purine (2 AP) prior infection. This increase in survival, which we call "2-AP-reactivation", has the following characteristics: (1) it is not accompanied by mutagenesis; (2) it occurs in recA- and lexA- bacterial mutants; (3) is abolished in the polA- mutant (deficient in DNA polymerase I).
mesh_terms: D015075:2-Aminopurine / Q000494:pharmacology*; D000225:Adenine / Q000031:analogs & derivatives*; D010582:Bacteriophage lambda / Q000528:radiation effects*; D004256:DNA Polymerase I / Q000502:physiology; D004260:DNA Repair / Q000528:radiation effects*; D004279:DNA, Viral / Q000528:radiation effects*; D004926:Escherichia coli / Q000201:enzymology*; D009154:Mutation / Q000187:drug effects; D014466:Ultraviolet Rays
chemical_list: D004279:DNA, Viral; D015075:2-Aminopurine; D004256:DNA Polymerase I; D000225:Adenine
vernacular_title: La 2 amino-purine, un analogue de l'adénine, induit chez E. coli un mécanisme de réparation non mutagène agissant sur les lésions ultraviolettes dans l'ADN double-brin.