The effect of theophyllamine on T-lymphocyte activation in vitro.
Theophyllamine in similar concentrations as the therapeutic serum level was found to inhibit the proliferative response in mixed lymphocyte cultures (MLC) and cultures stimulated with purified protein derivative of tuberculin (PPD). Theophyllamine inhibited interleukin 2 (IL-2) production of lymphocytes stimulated with phytohemaglutinin (PHA) and IL-2-dependent growth of T-cell lines, but had no effect on PPD pulsing of antigen-presenting cells.
D000628:Aminophylline / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000276:immunology*
D007376:Interleukin-2; D000628:Aminophylline