Knowledge-based simulation of genetic regulation in bacteriophage lambda.
We have developed a general-purpose computer program for the functional simulation of regulatory genetics. This simulator is knowledge-based and was developed using the Unit System, a software tool for the acquisition, representation, and manipulation of hierarchically organized knowledge. The advantages of a knowledge-based design are presented, and the simulator's architecture is described. Its performance on the decision between lytic and lysogenic growth in Bacteriophage Lambda is reported.
D010582:Bacteriophage lambda / Q000235:genetics*; D003201:Computers; D005786:Gene Expression Regulation; D005814:Genes, Viral; D008242:Lysogeny; D008962:Models, Theoretical; D014158:Transcription, Genetic; D014779:Virus Replication