Inhibition of gastric emptying by chinoform and its relation to strain differences in acute toxicity of chinoform in mice.
Significant difference in oral LD50 of chinoform in mice was observed between strains C57BL/6 and C3H/He. C57BL mice were more sensitive to oral toxicity of chinoform than C3H mice. Doses of 200 mg/kg of chinoform gave a more rapid and prolonged inhibition of gastric emptying in C57BL mice than in C3H mice. Small intestinal transit in C57BL mice was slower than that in C3H mice. The delayed gastric emptying and slow small intestinal transit in C57BL mice affected the blood levels of chinoform, and these factors may be, at least partly, responsible for the difference in the lethal toxicity of chinoform between the two strains.
D000818:Animals; D007464:Clioquinol / Q000633:toxicity*; D005746:Gastric Emptying / Q000187:drug effects*; D006912:Hydroxyquinolines / Q000633:toxicity*; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013045:Species Specificity
D006912:Hydroxyquinolines; D007464:Clioquinol