[Plaster of Paris pellets containing antibiotics in the treatment of bone infection. New combinations of plaster with antibiotics].
The author has tested the action of antibiotic-loaded plaster of Paris loaded pellets in 15 patients with success in 13. Previous studies using plaster of Paris for filling bone defects are noted, plaster being well tolerated and absorbable. Gentamycin, Fucidin and Cefazolin were tested first. In a second series, Netilmicin, Amikacin, Rifamycin and Rifampicin were also used. The preparation of the pellets is fully described. In most instances they can be sterilized by gamma rays except for Fucidin and Cefazolin. Several hundred pellets can be used simultaneously. A study of the elimination of antibiotic in the urine was made. It was concluded that the concentrations obtained by this method in the tissues were highly satisfactory.
D000583:Amikacin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000378:metabolism; D001842:Bone and Bones / Q000601:surgery; D002133:Calcium Sulfate; D004343:Drug Implants; D006801:Humans; D007700:Kinetics; D009428:Netilmicin / Q000008:administration & dosage; D010019:Osteomyelitis / Q000188:drug therapy / Q000628:therapy*; D012293:Rifampin / Q000008:administration & dosage; D012294:Rifamycins / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D004343:Drug Implants; D012294:Rifamycins; D009428:Netilmicin; D000583:Amikacin; D012293:Rifampin; D002133:Calcium Sulfate
Billes de plâtre de Paris aux antibiotiques dans le traitement de l'infection osseuse. Nouvelles associations plâtre-antibiotiques.