Contact allergy to trimethylolpropane triacrylate (TMPTA) in an aziridine plastic hardener.
4 workers developed hand and face dermatitis when exposed to a floor top coat. This contained a polyurethane and a polyfunctional aziridine hardener and additives. The aziridine hardener was made by reacting propyleneimine with a polyfunctional acrylate, trimethylolpropane triacrylate (TMPTA). All 4 reacted to the hardener and to TMPTA, which is present in excess. 2 of them also reacted to pentaerythritol triacrylate (PETA), which can be used in the production of aziridine hardeners. TMPTA and PETA cross-react, and are known sensitizers in UV-hardening acrylates. The present finding shows that well-known sensitizers can be found in hidden sources when used in a quite different chemical process.
D000179:Acrylates / Q000009:adverse effects*; D055598:Chemical Phenomena; D002621:Chemistry; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D006229:Hand Dermatoses / Q000209:etiology; D006801:Humans; D010328:Patch Tests
D000179:Acrylates; C027993:trimethylolpropane triacrylate