Serum-mediated inhibition of human lymphocyte fc gamma-receptors in extrinsic and intrinsic bronchial asthma.
Sera from 48 patients with extrinsic asthma and 37 with intrinsic asthma were screened for immune complexes using the EA-rosette inhibition assay. Significant levels of EA-rosette inhibition were found in both groups when compared with normal sera. The serum inhibitory factor(s) is, however, more likely to be an anti-lymphocyte antibody of the IgM class than an immune complex as originally expected.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis; D001249:Asthma / Q000276:immunology / Q000473:pathology*; D002469:Cell Separation; D002499:Centrifugation, Density Gradient; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000166:cytology; D009504:Neutrophils / Q000166:cytology; D011817:Rabbits / Q000276:immunology*; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors*; D012397:Rosette Formation; D013696:Temperature
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D017452:Receptors, IgG; D011971:Receptors, Immunologic