[Circadian rhythm of catecholamine excretion, effect of L-DOPA and Nacom in various diseases of the nervous system].
The activity of the sympathoadrenal system (SAS) was studied in 132 patients with central nervous system diseases such as parkinsonism, deforming muscular dystonia (DMD), Huntington's chorea, myopathy and asthenic neurosis. The estimation was based on determinations of urine catecholamine (CA) excretion with the help of the fluorometric method developed by E. Sh. Matlina et. al. (1965). The control group included 50 healthy subjects. The findings obtained confirmed the reported data concerning the role of CA in the pathogenesis of the studied forms of nervous pathology. The study showed a decrease in dopamine excretion (DA) in parkinsonism, its increase in Huntington's chorea and DMD, and insufficiency of SAS activity in myopathy. Furthermore, additional criteria pointing to alterations in the diurnal SAS activity in the patients were revealed. These changes manifested themselves in the disruption of the diurnal rhythm of CA excretion as well as in the deficiency of DOPA and DA synthesis and deposition following a single dose of L-DOPA and nacome.
D000328:Adult; D000368:Aged; D002230:Carbidopa / Q000627:therapeutic use*; D002395:Catecholamines / Q000652:urine*; D004338:Drug Combinations / Q000627:therapeutic use; D004422:Dystonia Musculorum Deformans / Q000652:urine; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000652:urine; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000652:urine; D009422:Nervous System Diseases / Q000188:drug therapy / Q000652:urine*; D009497:Neurotic Disorders / Q000652:urine; D010300:Parkinson Disease / Q000652:urine
D002395:Catecholamines; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa
Sutochnyĭ ritm ékskretsii katekholaminov, vliianie L-DOFA i nakoma pri nekotorykh zabolevaniiakh nervnoĭ sistemy.