Immunogenetic analysis of rheumatoid arthritis.
Statistical association between rheumatoid arthritis (RA) and the HLA-D region antigen, HLA-DR4-MT3, was confirmed. HLA-linked immune suppression genes (Is-genes) were demonstrate, which controlled proliferative T cell response to streptococcal cell wall antigen or IgE response to cedar pollen antigen in vitro. The absence of such genes may predispose to autoimmune diseases or allergy. An HLA-linked Is-gene in negative linkage disequilibrium with HLA-DR4-MT3 was proposed to be one of the most likely genetic factors determining the resistance to RA.
D001172:Arthritis, Rheumatoid / Q000209:etiology* / Q000235:genetics; D001327:Autoimmune Diseases / Q000209:etiology* / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000009:adverse effects* / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D012737:Sex Factors; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006680:HLA Antigens