title: Structural differences of heparan sulfates according to the tissue and species of origin.
abstract: Some structural features of thirteen heparan sulfates isolated from different mammalian tissues and species are reported. Two N-acetylated disaccharides, one of then O-sulfated and two N-sulfated disaccharides, one of then 6-sulfated are formed from these compounds by the combined action of heparitinases I and II from Flavobacterium heparinum. The relative proportions of the four disaccharide units vary quite significantly among the thirteen heparan sulfates indicating that the structure of these polymers are tissue and species specific. Based on the frequency of appearance of each one of the disaccharides it was calculated that 10(36) types of heparan sulfates might theoretically be found. The possible role of these polyanions in cell-cell recognition is discussed in view of the present findings.
mesh_terms: D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D004187:Disaccharides / Q000032:analysis; D004285:Dogs; D006025:Glycosaminoglycans; D006168:Guinea Pigs; D006497:Heparan Sulfate; D006801:Humans; D008970:Molecular Weight; D009928:Organ Specificity; D011817:Rabbits; D013045:Species Specificity
chemical_list: D004187:Disaccharides; D006025:Glycosaminoglycans; D006497:Heparan Sulfate