title: Inhibition of synexin activity and exocytosis from chromaffin cells by phenothiazine drugs.
abstract: Synexin activity was found to be inhibited by low concentrations of the phenothiazine drugs, trifluoperazine and promethazine. Both drugs were also similarly effective at blocking nicotine and veratridine-induced catecholamine secretion from cultured chromaffin cells. These data thus indicate that synexin may be a target of phenothiazine drugs when they block secretion from chromaffin cells.
mesh_terms: D000313:Adrenal Medulla / Q000187:drug effects; D000818:Animals; D017310:Annexin A7; D002417:Cattle; D002838:Chromaffin System / Q000187:drug effects* / Q000378:metabolism; D005089:Exocytosis / Q000187:drug effects*; D066298:In Vitro Techniques; D010640:Phenothiazines / Q000494:pharmacology*; D011506:Proteins / Q000037:antagonists & inhibitors*
chemical_list: D017310:Annexin A7; D010640:Phenothiazines; D011506:Proteins