[Mechanism of the inhibiting effect of atypical antidepressants and psychostimulants on the synaptosomal uptake of monoamines].
The effects of viloxazine and zimelidine on reverse monoamine neurotransmitter uptake by crude synaptosomal fraction of the rat brain were studied and compared to those of imipramine, amphetamine and cocaine. Imipramine noncompetitively inhibited the uptake of all the monoamines under study, with a greater specificity as regards serotonin. Viloxazine and zimelidine strongly inhibited the transport of noradrenaline, dopamine and serotonine, the transport of the latter being inhibited to a greater degree. Kinetic analysis showed the active centers of noradrenaline and dopamine carriers to be very much alike, those of catecholamine and serotonin carriers to be less alike. The data obtained made it possible to describe (at least partly) the structure of the active centers of monoamine carriers and to specify the action modes of antidepressants and psychostimulants.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism*; D003042:Cocaine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D007099:Imipramine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism; D014745:Viloxazine / Q000494:pharmacology; D015031:Zimeldine
D000928:Antidepressive Agents; D012701:Serotonin; D015031:Zimeldine; D014745:Viloxazine; D000661:Amphetamine; D001977:Brompheniramine; D003042:Cocaine; D007099:Imipramine; D004298:Dopamine; D009638:Norepinephrine
Mekhanizm ingibiruiushchego vliianiia atipichnykh antidepressantov i psikhostimuliatorov na sinaptosomal'nyĭ zakhvat monoaminov.