Serum lipids and proteins during treatment with a new oral contraceptive combination containing desogestrel.
The present study was carried out to measure lipid and protein levels in serum of healthy women during treatment with a new oral contraceptive combination containing 0.075 mg desogestrel (Org 2969, 17 alpha-ethinyl-18-methyl-11-methylene-4-estren-17-ol) plus 0.050 mg ethinyloestradiol per tablet. All 30 volunteers took 1 tablet daily for 21 consecutive days, followed by a tablet-free period of 7 days. Treatment lasted 3 months. At the end of treatment serum total cholesterol had increased by 0.26 mmol/l (5.0%), high-density lipoprotein-cholesterol by 0.22 mmol/l (15.2%) and triglycerides by 0.43 mmol/l (50%); the calculated low-density lipoprotein cholesterol had decreased by 0.16 mmol/l (4.9%). All lipid concentrations had returned to initial levels 2 months after treatment stopped. After 3 months treatment serum ceruloplasmin, cortisol-binding globulin capacity, sex-hormone-binding globulin capacity and thyroxine-binding globulin had significantly increased by 85.2, 133, 206 and 101%, respectively. All protein levels returned to normal 2 months after treatment stopped. The relationship between serum lipids and hormone-binding proteins has been discussed, as well as the significance of the high-density lipoprotein level with regard to contraceptive treatment.
D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D002352:Carrier Proteins / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D017135:Desogestrel; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D009652:Norpregnenes / Q000494:pharmacology*; D011247:Pregnancy; D012738:Sex Hormone-Binding Globulin; D013975:Thyroxine-Binding Proteins / Q000032:analysis; D014280:Triglycerides / Q000097:blood*
D001798:Blood Proteins; D002352:Carrier Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D009652:Norpregnenes; D012738:Sex Hormone-Binding Globulin; D013975:Thyroxine-Binding Proteins; D014280:Triglycerides; C027091:cortisol binding globulin; D004997:Ethinyl Estradiol; D017135:Desogestrel; D002784:Cholesterol; D002570:Ceruloplasmin