Glycoprotein IIb-IIIa complex in platelets of patients and heterozygotes of Glanzmann's thrombasthenia.
The concentration of the glycoprotein (GP) IIb-IIIa complex in thrombasthenic platelets of 8 patients of 6 families has been estimated. In the thrombasthenic platelets of 3 patients this complex is absent (thrombasthenia type I and subtype I). In 2 patients only traces are detectable and in 3 patients GP IIb-IIIa complex is strongly reduced (less than 5%). On the basis of the haemostatic data as well as the content of GP IIb-IIIa complex and platelet fibrinogen the classification of these types as subtypes of thrombasthenia type II is discussed. The diagnostic applicability of GP IIb-IIIa complex determination for heterozygote detection in types of thrombasthenia with absent or extremely reduced GP IIb-IIIa complex is shown.
D001791:Blood Platelet Disorders / Q000235:genetics*; D001792:Blood Platelets / Q000032:analysis; D006580:Genetic Carrier Screening; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D010375:Pedigree; D010980:Platelet Membrane Glycoproteins
D006023:Glycoproteins; D010980:Platelet Membrane Glycoproteins