[Whipple disease: clinical and immunohistologic findings in 2 cases].
Two cases with typical clinical and histological manifestations of Whipple's disease were reported. Peroral jejunal biopsies were studied in the florid stage and during remission achieved by tetracycline therapy. A complete absence of immunoglobulin-containing cells (Ig-CC) and an increased number of mast cells in the mucosa were established in one of the cases. A 5-fold decrease of the mucosal Ig-CC was found by immunofluorescent morphometry in the second case. An increased Ig-CC number and histological restitution of the mucosa were shown in the first case during remission, whereas histological alterations and decreased Ig-CC number persisted in the second case despite of clinical improvement. The HLA-locus B27 was not available in the reported cases.
D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000473:pathology*; D007583:Jejunum / Q000473:pathology; D008264:Macrophages / Q000648:ultrastructure; D008297:Male; D008871:Microvilli / Q000648:ultrastructure; D008875:Middle Aged; D008061:Whipple Disease / Q000175:diagnosis* / Q000473:pathology
D007136:Immunoglobulins
Der Morbus Whipple: Klinische und immunhistologische Befunde in zwei Fällen.