title: Studies on the potency test of HB vaccine by the parallel line assay method in guinea pigs.
abstract: The parallel line assay method was applied on the potency test of HB vaccine in guinea pigs. The applicability of the method was investigated to obtain information on the possible effect of inactivation process of HBs antigen, on the magnitude of adjuvant effect of aluminum compound and so on. The precision of the method was found to be comparable to those of diphtheria and tetanus toxoids.
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000936:Antigen-Antibody Complex; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D017325:Hepatitis B Vaccines; D007114:Immunization; D012044:Regression Analysis; D014765:Viral Vaccines / Q000494:pharmacology*
chemical_list: D000936:Antigen-Antibody Complex; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014765:Viral Vaccines