Australian goats detoxify the goitrogen 3-hydroxy-4(1H) pyridone (DHP) after rumen infusion from an Indonesian goat.
The failure of Australian goats fed Leucaena leucocephala (leucaena) to degrade 3-hydroxy-4(1H) pyridone (DHP), the goitrogenic metabolite of mimosine, was overcome when they were infused with rumen fluid from an Indonesian goat. The leucaena toxicity problem in Australia may well be solved by transfer of specific bacteria capable of degrading DHP anaerobically.
D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D013956:Antithyroid Agents; D001315:Australia; D001419:Bacteria / Q000378:metabolism; D006041:Goats / Q000378:metabolism*; D008658:Inactivation, Metabolic; D007214:Indonesia; D008297:Male; D011728:Pyridones / Q000378:metabolism* / Q000652:urine; D012417:Rumen / Q000382:microbiology*
D013956:Antithyroid Agents; D011728:Pyridones; C020366:3-hydroxy-4-pyridone