[Alteration of the mechanical properties of cartilage after intra-articular administration of drugs in vitro].
In this study the biomechanical effect of intra-articularly applicable drugs on the articular cartilage was analyzed in vitro. Arthrotic cartilage cylinders from tibia plateaus were used, which were removed during endoprosthetic joint replacement. The elasticity of these specimens were measured before and after a 12-day incubation in a medium containing Hank's solution and serum. Five successive loading and unloading cycles from 0 to 10 N were applied, using an indenter with a diameter of 3 mm. The indentation velocity was 0.2 mm/s. Drugs with different postulated influence on the cartilage metabolism were added in various concentrations. A change in the mechanical behavior of the cartilage in relation to drug concentration could be seen in most of the medications; the change could be described using a 3rd-degree polynoma. The possible influence of this biomechanical alteration on arthrotic pain and arthrotic progression is discussed.
D000368:Aged; D001168:Arthritis / Q000503:physiopathology*; D001623:Betamethasone / Q000031:analogs & derivatives / Q000494:pharmacology; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000187:drug effects / Q000503:physiopathology*; D002478:Cells, Cultured; D003470:Culture Media; D004338:Drug Combinations / Q000494:pharmacology; D004548:Elasticity; D005944:Glucosamine / Q000494:pharmacology; D006025:Glycosaminoglycans / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D008667:Metalloproteins / Q000494:pharmacology; D008875:Middle Aged; D013977:Tibia / Q000503:physiopathology; D014020:Tissue Extracts / Q000494:pharmacology
D003470:Culture Media; D004338:Drug Combinations; D006025:Glycosaminoglycans; D008667:Metalloproteins; D014020:Tissue Extracts; C040007:neyarthros; C010034:Arteparon; C017260:diprosone Depot; C003807:Dona 200; D001623:Betamethasone; D008012:Lidocaine; D005944:Glucosamine; C005180:orgotein
Anderung der mechanischen Eigenschaften des Knorpels unter dem Einfluss intraartikulär applizierbarer Pharmaka in vitro.