Effects of nicotinamide and insulin on glycosylated hemoglobin and blood glucose in thyroidectomized streptozotocin-diabetic rats.
The present study deals with the effects of nicotinamide and insulin on glycosylated hemoglobin (HbA1) and blood glucose in thyroidectomized streptozotocin (STZ)-diabetic male rats. Nicotinamide (500 mg/kg body wt., i.p.) significantly decreased the levels of HbA1 and blood glucose in both STZ-treated (65 mg/kg body wt., i.v.) intact and STZ-treated thyroidectomized animals. Administration of NPH-insulin recovered hyperglycemia, and the increased HbA1 in thyroidectomized STZ-diabetic rats to control levels.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009536:Niacinamide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D009536:Niacinamide