[Use of nicotinamide for correcting the disordered nicotinic acid allowance of patients with noncoronarogenic heart diseases].
A study was made of the effects of different doses of nicotinamide (NA) on the nicotinic acid supply in 37 patients with rheumocarditis of varying severity without circulation failure, in 5 patients with infectious-allergic myocarditis, and in 10 patients with tonzilogenous myocardiodystrophy. Twenty-eight patients with analogous diseases given unified therapy without NA and 70 healthy subjects were examined for control purposes. The rate of vitamin PP supply was evaluated from the content of NAD and NADP in red cells, from that of N'-methylnicotinamide in the blood and its excretion with urine. Administration of NA in a dose of 50 mg a day for 2 weeks to patients with tonsilogenous myocardiodystrophy made the indicators under consideration return to normal. The attainment of complete correction of abnormal vitamin PP supply in patients with rheumocarditis and infectious-allergic myocarditis demands a 2-time increase of the drug dose.
D000328:Adult; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000188:drug therapy* / Q000378:metabolism; D009243:NAD / Q000097:blood; D009249:NADP / Q000097:blood; D009536:Niacinamide / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000378:metabolism; D009539:Nicotinic Acids / Q000172:deficiency*; D012214:Rheumatic Heart Disease / Q000188:drug therapy* / Q000378:metabolism
D009539:Nicotinic Acids; D009243:NAD; D009536:Niacinamide; D009249:NADP; C024058:N(1)-methylnicotinamide
Primenenie nikotinamida dlia korrektsii narushennioĭ obespechennosti nikotinovoĭ kislotoĭ bol'nykh s nekoronarogennymi zabolevaniiami serdtsa.