title: Hybrid type glycolipids (lacto-ganglio series) with a novel branched structure. Their presence in undifferentiated murine leukemia cells and their dependence on differentiation.
abstract: The structures of these glycolipids are hybrids of the lacto and ganglio series, which are characterized by the presence of GlcNAc beta 1----3 and GalNAc beta 1----4 linked to the Gal residue of Gal beta 1----4Glc beta 1----1Cer. This new hybrid series can be designated as "lacto-ganglio series." These glycolipids are present in undifferentiated murine leukemia cells. Their concentration declines with differentiation and they are virtually absent in differentiated M1+ cells, suggesting that lacto-ganglio structures could be markers of undifferentiated, malignant myeloid cells.
mesh_terms: D000818:Animals; D002236:Carbohydrate Conformation; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006017:Glycolipids / Q000302:isolation & purification; D006028:Glycosphingolipids / Q000302:isolation & purification*; D006596:Hexosaminidases; D007942:Leukemia, Experimental / Q000378:metabolism*; D013058:Mass Spectrometry; D008745:Methylation; D051379:Mice; D010944:Plants / Q000201:enzymology; D001619:beta-N-Acetylhexosaminidases
chemical_list: D006017:Glycolipids; D006028:Glycosphingolipids; D006596:Hexosaminidases; D001619:beta-N-Acetylhexosaminidases