title: [Relative biological effectiveness (RBE) of d(50)-Be neutrons (Louvain-la-Neuve) and p(34)-Be neutrons (Orleans) for early intestinal tolerance in mice].
abstract: This paper compares the RBE of a neutron beam produced by 50 MeV deuterons on beryllium [d(50)-Be] at the cyclotron CYCLONE of Louvain-La-Neuve and of a neutron beam produced by 34 MeV protons on beryllium [p(34)-Be] of the Hôpital Régional d'Orléans. Early intestinal tolerance in mice was choosen as biological criterium; it is derived from LD50 determination after single and fractionated abdominal irradiation. For d(50)-Be neutrons, RBE was 1.8 +/- 0.2 (with respect to 60Co gamma-rays) for a single fraction. It increases up to 2.1 +/- 0.2 for an irradiation in 2 fractions (3.5 h interval) and reaches 2.5 +/- 0.3, 2.7 +/- 0.3 and 2.5 +/- 0.3 for irradiations in 10 fractions (7 and 3.5 h interval) and 20 fractions (3.5 h interval) respectively. RBE values observed for p(34)-Be neutrons (with respect to 60Co gamma-rays) are not significantly different. For a single fraction RBE = 1.7 +/- 0.2 and for 2 fractions (3.5 h interval) RBE = 2.0 +2- 0.2.
mesh_terms: D000818:Animals; D001530:Belgium; D001608:Beryllium; D005602:France; D007413:Intestinal Mucosa / Q000528:radiation effects; D007928:Lethal Dose 50; D051379:Mice; D008807:Mice, Inbred BALB C; D009502:Neutrons; D010315:Particle Accelerators; D011836:Radiation Tolerance; D012062:Relative Biological Effectiveness
chemical_list: D001608:Beryllium
vernacular_title: Efficacité biologique relative (EBR) des neutrons d(50)-Be (Louvain-la-Neuve) et des neutrons p(34)-Be (Orléans) pour la tolérance intestinale précoce chez la souris.