title: Physiological dependency between the hypothalamus and the thymus in Wistar rats. II. The neurosecretion level and microstructural changes following para-chlorophenylalanine administration. The differences in DL-5-hydroxy G-3H tryptophane incorporation in the hypothalamus of normal and thymectomized rats.
abstract: The experiments were carried out on male Wistar rats, both normal and thymectomized in which the thymus was excised in 12th h of life. 8 weeks later, the animals were administered parachlorophenylalanine [PCPA], i.e. a compound inhibiting tryptophane hydroxylase, in the amount of 200 mg/kg of body weight. The studied hypothalamus preparations, i.e. supraoptical [NSO] and paraventricular nuclei [NPV] revealed an increased level of Gomori-positive neurosecretory material in thymectomized rats when compared to control animals. It was observed that the former rodents manifested an elevated incorporation of the isotope, i.e. DL-5-Hydroxy [G-3H] Tryptophane. The calculations performed by the use of the Gosset's t-test ("Student's") showed that the difference was statistically significant (p less than 0.001).
mesh_terms: D006916:5-Hydroxytryptophan / Q000378:metabolism*; D000818:Animals; D010134:Fenclonine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009489:Neurosecretion / Q000187:drug effects*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains / Q000033:anatomy & histology / Q000502:physiology*; D013237:Stereoisomerism; D013495:Supraoptic Nucleus / Q000166:cytology; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology*
chemical_list: C020261:4-chlorophenylalanine methyl ester; D006916:5-Hydroxytryptophan; D010134:Fenclonine