Feedback control of the secondary antibody response. I. A suppressor, suppressor-inducer mechanism from the interaction of B-memory cells with Lyt 2- T cells.
The cellular elements of an antigen-specific suppressor system for secondary antibody responses have been identified, using positive cell-selection techniques in the fluorescence-activated cell sorter. In a double-adoptive transfer of memory cells for a thymus-dependent antigen, from one irradiated recipient to another, antigen-specific suppressor T cells are recruited after a critical time in the primary recipient. It is also a source of B cells that are able to induce further suppressors in carrier-primed, but otherwise naive donors. There are two distinct routes, therefore, for the generation of suppressor T cells: primary induction by adoptive transfer with antigen, or secondary induction by B cells recruited in the primary irradiated host. We have shown that both primary and secondary suppressors are recruited from a Lyt 2- memory population, although the Lyt 2 alloantigen is expressed at the effector stage.
D000818:Animals; D000917:Antibody Formation; D002469:Cell Separation; D005246:Feedback; D005434:Flow Cytometry; D007116:Immunization, Passive; D007156:Immunologic Memory; D007518:Isoantibodies / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007518:Isoantibodies; C029805:Lyt antibodies