[Functional value of the pancreatic microtransplant in rats after intraductal injection of chloroprene].
Microsurgery permits the carrying out of pancreatic isografts in inbred rats. By this experimental pattern, it is possible to study the technical problems of pancreatic transplantation without interference from the immune reaction. The research of suppressing exocrine function in the graft by intraductal chloroprene injection and the study of the short-term effects of this procedure on endocrine function of the pancreas are the aim of this work. These experiments show that injection of chloroprene into the main pancreatic duct is an effective method of selective suppression of pancreatic exocrine function without interference with endocrine function. This procedure prevents the high mortality and morbidity which characterizes the other procedures with pancreatic juice derivation.
D000818:Animals; D002070:Butadienes / Q000494:pharmacology*; D002737:Chloroprene / Q000008:administration & dosage / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D007267:Injections; D008297:Male; D008866:Microsurgery; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D016035:Pancreas Transplantation; D010183:Pancreatic Ducts; D051381:Rats; D011917:Rats, Inbred Lew
D002070:Butadienes; D002737:Chloroprene
Contribution à l'étude de la valeur fonctionnelle du microtransplant pancréatique de rat après injection intra-canalaire de chloroprène.