Vohwinkel's keratoma hereditarium mutilans.
A 35-year-old black man and his two daughters have massive keratoderma of the palms and soles and ainhum-like constrictions of the fifth toes in two of the three patients. Although there are various types of familial hyperkeratosis, our patients have dermatologic manifestations most consistent with Vohwinkel's keratoma hereditarium mutilans.
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000235:genetics* / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology