Ipratropium in the treatment of patients with perennial rhinitis.
Rhinorrhea is due to increased parasympathetic activity. This study was undertaken in order to study the applicability and efficacy of ipratropium, an anticholinergic drug, in patients with perennial rhinitis seen in an allergy clinic. Thirteen patients were included in the double-blind, cross-over study following screening with methacholine test. The number of paper tissues used during the period with active drug decreased significantly. Other variables did not change significantly. Eight patients preferred the active drug. The findings of this study suggest that ipratropium bromide is a valuable addition in the treatment of patients with perennial rhinitis with rhinorrhea.
D000328:Adult; D001286:Atropine Derivatives / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D008875:Middle Aged; D009299:Nasal Provocation Tests; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D001286:Atropine Derivatives; D008688:Methacholine Compounds; D016210:Methacholine Chloride; D009241:Ipratropium