title: Myocardial lesions in experimental acute heart failure.
abstract: The present study concerns the morphological and biochemical lesional picture of the myocardium in cases of acute heart failure induced by various experimental models: ligature of the coronary artery, direct electric stimulation of the heart by catheterism, lethal hemorrhage, pneumothorax, beta-adrenergic shock. Worthy of note was the similitude of the lesional myocardium pictures characterized electron microscopically by a wide range of lesions, from reversible to focal cytolysis, and biochemically by decrease of mitochondrial enzymes, ATP, Mg2-1 X K+ and increase of Na+ X H2O, Ca2+. Problems linked to the pathogenesis, reversibility of the lesions and efficiency of certain therapeutical means are discussed.
mesh_terms: D000208:Acute Disease; D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006168:Guinea Pigs; D006333:Heart Failure / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats