title: [Vitamin para-aminobenzoic acid inhibits development of SOS function in tif-1 mutants of Escherichia coli at nonpermissive temperatures].
abstract: The development of "SOS" inducible functions in lysogenic and non-lysogenic strains of Escherichia coli tif-1 sfiA11 (lambda) at nonpermissive temperature of 42 degrees C was strongly suppressed by para-aminobenzoic acid (PABA). The rate of prophage lambda induction decreased 400 times, as compared to the control level; the efficiency of W-reactivation of UV-irradiated phage lambda decreased 37.5 to 16%. PABA also inhibited to some extent (1.5 times) the process of inducible recombination on the RecF pathway. The processes of spontaneous lambda induction and W-reactivation, as well as spontaneous recombination on RecBC and RecF pathways, were not influenced by PABA. The above data are in accordance with previous studies of PABA action when the manifestation of "SOS" functions was induced by chemical mutagens. The action of PABA has been tentatively interpreted on the basis of negative control of "SOS" repair pathway.
mesh_terms: D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D062365:Aminobenzoates / Q000494:pharmacology*; D010582:Bacteriophage lambda / Q000235:genetics* / Q000254:growth & development; D004260:DNA Repair / Q000187:drug effects*; D004269:DNA, Bacterial / Q000235:genetics*; D003864:Depression, Chemical; D004926:Escherichia coli / Q000235:genetics*; D008242:Lysogeny / Q000187:drug effects; D009154:Mutation; D011995:Recombination, Genetic / Q000187:drug effects; D013696:Temperature; D014775:Virus Activation / Q000187:drug effects
chemical_list: D062365:Aminobenzoates; D004269:DNA, Bacterial; D010129:4-Aminobenzoic Acid
vernacular_title: Vitamin para-aminobenzoĭnaia kislota prepiatstvuet razvitiiu "SOS"-funktsiĭ v tif-1-mutantakh Escherichia coli pri nepermessivnoĭ temperature.