Uptake of zimelidine and inhibition of uptake of 5-hydroxytryptamine in the isolated, ventilated and perfused rat lung.
Uptake of zimelidine from the perfusate in isolated perfused rat lung was concentration-dependent. Accumulated zimelidine was released from the lung according to a two-compartment model and lidocaine injected as a bolus did partially displace zimelidine. The properties of the displacement curves indicated, however, that the affinity to the lung tissue was greater for zimelidine than lidocaine. Uptake of 5-hydroxytryptamine added to the perfusion buffer was inhibited by zimelidine. The displacement of zimelidine by lidocaine did not, statistically, significantly alter the extraction of 5-hydroxytryptamine.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology; D008168:Lung / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D011725:Pyridines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D015031:Zimeldine
D011725:Pyridines; D012701:Serotonin; D015031:Zimeldine; D008012:Lidocaine; D001977:Brompheniramine