title: Sensitivity to the weed killer DNA-nitralin and cross-sensitivity to dinitrochlorobenzene.
abstract: A man, with a dermatitis acquired while working in a factory producing a weed killer, showed sensitivity to 4-methylsulfonyl 2,6-dinitro-N,N-dipropylaniline (DNA-nitralin) and its precursor, 4-chloro 3,-5-dinitrophenylmethyl sulfone (DNC), and cross-sensitivity to dinitrochlorobenzene (DNCB). Sensitization capacities of DNA-nitralin and DNC compared with DNCB, and cross-sensitizations among 11 dinitrobenzene derivatives, including DNA-nitralin, DNC, and DNCB, were studied in guinea pigs. We found that the order of potency was DNCB, DNC, and DNA-nitralin for the sensitization capacity, and that cross-sensitizations may occur among DNCB, DNC, DNA-nitralin, and dinitrofluorobenzene, in comparatively high incidence.
mesh_terms: D000814:Aniline Compounds / Q000009:adverse effects* / Q000276:immunology; D000818:Animals; D003429:Cross Reactions; D009783:Dermatitis, Occupational / Q000139:chemically induced* / Q000276:immunology; D004137:Dinitrochlorobenzene / Q000031:analogs & derivatives / Q000276:immunology*; D004139:Dinitrofluorobenzene / Q000276:immunology; D006168:Guinea Pigs; D006540:Herbicides / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009578:Nitrobenzenes / Q000276:immunology*; D010328:Patch Tests
chemical_list: D000814:Aniline Compounds; D004137:Dinitrochlorobenzene; D006540:Herbicides; D009578:Nitrobenzenes; C037647:4-chloro-3,5-dinitrophenylmethyl sulfone; C003499:nitralin; D004139:Dinitrofluorobenzene