[Potentiation by clofibride of the heparin-induced clearing reaction (intravascular hydrolysis of neutral lipids), in hyperlipemic rabbits].
A 16 days clofibride treatment in hyperlipaemic rabbit (fat supply), reduces hypertriglyceridemia and hypercholesterolemia. Heparine clearing reaction, performed on the 17th day, with the daily clofibride dose ingested in one time, is increased. The exaggerated intravascular lipids hydrolysis could explain, in part, the hypolipaemic action of clofibride.
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000097:blood*; D006949:Hyperlipidemias / Q000097:blood*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007700:Kinetics; D011817:Rabbits; D014280:Triglycerides / Q000097:blood*
D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents; D014280:Triglycerides; C007089:clofibride; D006493:Heparin; D002784:Cholesterol; D002994:Clofibrate
Potentialisation par le clofibride de la réaction de clarification à l'héparine (hydrolyse intravasculaire des lipides neutres), chez le lapin hyperlipémique.