DNA damage and chronic neuronal degenerations.
DNA plays an essential role not only in dividing cells, but also in postmitotic cells such as neurons. Accumulated damage to the nuclear DNA will result in damage to neuronal metabolism. There is suggestive evidence of altered DNA in ALS, Alzheimer's and Parkinson's diseases, and of deficiency of DNA repair mechanisms in these age-related neuronal degenerations and in Huntington's disease. We suggest that these DNA abnormalities are more likely to be the cause of the diseases, rather than an effect of the disease process.
D000544:Alzheimer Disease / Q000378:metabolism; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology / Q000378:metabolism*; D001480:Basal Ganglia Diseases / Q000209:etiology / Q000378:metabolism*; D002273:Carcinogens / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004247:DNA / Q000378:metabolism* / Q000528:radiation effects; D004260:DNA Repair; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism
D002273:Carcinogens; D003432:Cross-Linking Reagents; D004247:DNA