title: Anti-inflammatory action of drugs that raise adenosine-3',5'-cyclic monophosphate and putrescine levels in-vivo.
abstract: Isoprenaline and salbutamol, two beta-adrenoceptor agonist drugs, and 3-isobutyl-methyl xanthine and thioacetamide have been shown to be anti-inflammatory. Their mode of action is probably due to an increase in the levels of the three endogenous substances adenosine-3',5'-cyclic monophosphate and putrescine and spermidine in-vivo.
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D000242:Cyclic AMP / Q000378:metabolism*; D004487:Edema / Q000209:etiology / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D011700:Putrescine / Q000378:metabolism*; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D000242:Cyclic AMP; D007545:Isoproterenol; D000420:Albuterol; D015056:1-Methyl-3-isobutylxanthine; D011700:Putrescine