[Effect of epidermal chalones on the development and growth of cheek pouch tumors in the hamster].
To the cheek pouch mucosa of 118 male Syrian golden hamsters 0.5% acetone solution of 7,12-dimethylbenz (a) anthracene was applied 3 times a week during 2 months. Two months after beginning of the experiments all the hamsters developed tumors. Since that time a mixture of epidermal G1 and G2 chalones was applied to the cheek pouch mucosa of the experimental animals 5 times a week. The control hamsters received saline alone. As compared to the control, the experimental hamsters demonstrated an increase in the life-span, tumor growth retardation and regression of part of the tumors. The data obtained attest to the anti-neoplastic action of chalones.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D002610:Cheek; D006224:Cricetinae; D006131:Growth Inhibitors / Q000494:pharmacology*; D008297:Male; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology
D006131:Growth Inhibitors; D015127:9,10-Dimethyl-1,2-benzanthracene
Deĭstvie épidermal'nykh keĭlonov na razvitie i rost opukholeĭ zashchechnogo meshka khomiachka.