[Effect of the administration of estrogen-antiestrogen combinations on the experimental infection of the hamster with Schistosoma mansoni].
In the purpose of establishing if the antiestrogens may inhib the protective effects of the estrogens during an experimental infection with Schistosoma mansoni in golden female hamster, we have studied the following estrogen-anti-estrogen associations: 17 beta-estradiol + trans-tamoxifène, 17 beta-estradiol + trans-clomifène, hexestrol + trans-tamoxifène. The decrease of the number of worms in the animals under experiment shows that these associations still give a protective effect. This protection is however weaker than the one which is induced by estrogens administration only. The interpretation of these results agree with the intervention of an estrogen receptor.
D000818:Animals; D006224:Cricetinae; D004338:Drug Combinations; D004965:Estrogen Antagonists / Q000008:administration & dosage*; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D008647:Mesocricetus; D011960:Receptors, Estrogen / Q000502:physiology; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000503:physiopathology*
D004338:Drug Combinations; D004965:Estrogen Antagonists; D004967:Estrogens; D011960:Receptors, Estrogen
Influence de l'administration d'associations estrogène-antiestrogène sur la parasitose expérimentale à Schistosoma mansoni du hamster.