High-level induction of gamma interferon with various mitogens in mice pretreated with Propionibacterium acnes.
Various T-cell mitogens induced high levels of circulating gamma interferon (IFN-gamma) in mice that had been pretreated with Propionibacterium acnes. Administration of lipopolysaccharide, a B-cell mitogen, to these mice also caused pronounced production of IFN-gamma in addition to IFN-alpha and IFN-beta. The enhanced induction was most marked at about 1 week after the pretreatment.
D000818:Animals; D004768:Enterotoxins / Q000494:pharmacology; D005692:Galactose Oxidase / Q000494:pharmacology; D007370:Interferon Type I / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis*; D007700:Kinetics; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology*; D011425:Propionibacterium acnes / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms
D004768:Enterotoxins; D007370:Interferon Type I; D008070:Lipopolysaccharides; D008934:Mitogens; C026066:enterotoxin A, Staphylococcal; D007371:Interferon-gamma; D005692:Galactose Oxidase