Effect of Bordetella pertussis vaccine on the sensitivity to a lymphotropic cytostatic agent in germfree mice.
A single injection of 15 mg/kg dianhydrodulcitol caused death at a higher proportion of germfree, specific pathogen free, and conventional mice with lymphocytosis and spleen hypertrophy induced by Bordetella pertussis vaccine pretreatment, than of unvaccinated controls.
D000818:Animals; D001284:Atrophy; D003961:Dianhydrogalactitol / Q000494:pharmacology*; D005260:Female; D005856:Germ-Free Life; D006984:Hypertrophy; D008208:Lymphatic System / Q000187:drug effects* / Q000276:immunology; D008218:Lymphocytosis / Q000209:etiology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010567:Pertussis Vaccine / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000473:pathology; D013402:Sugar Alcohols / Q000494:pharmacology*; D014611:Vaccination
D010567:Pertussis Vaccine; D013402:Sugar Alcohols; D003961:Dianhydrogalactitol