[Apoproteins A1 and B as markers of the severity of cirrhosis].
Since apolipoproteins A1 and B (Apo A1 and Apo B), which are the quantitatively predominant fractions of plasma lipoproteins, are synthetized and/or metabolized in the liver, their variations could represent a significant prognostic factor in patients with cirrhosis. In order to test this theory, the concentrations of Apo A1 and Apo B were measured in 43 patients with confirmed cirrhosis and were found to be reduced. These changes correlated with a number of biochemical tests measuring hepatic function and indicating severe cirrhosis, as well as with a clinico-biological severity index based on these biochemical tests and on the importance of clinical complications during the course of the disease. It is concluded that Apo 1 and Apo B determinations constitute a valuable index of liver synthetizing function.
D016632:Apolipoprotein A-I; D001053:Apolipoproteins / Q000096:biosynthesis / Q000097:blood* / Q000378:metabolism; D001055:Apolipoproteins B; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B
Les apoprotéines A1 et B témoins de gravité de la cirrhose.