Conservation of chromosomal high mobility group proteins HMG1 and HMG2 during differentiation of mouse myeloid leukemia cells.
The possible change in the levels of high mobility group proteins HMG1, HMG2 and histone H1 and H1(0) was investigated during mouse myeloid leukemia (M1) cell differentiation. In contrast to Friend erythroleukemia cells, no change occurred in the levels of any of these proteins. However, histone H1 phosphorylation significantly decreased. The results suggest that the loss of HMG1 and HMG2 proteins is not a generalized marker for cell differentiation.
D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D002868:Chromosomal Proteins, Non-Histone / Q000302:isolation & purification*; D006609:High Mobility Group Proteins; D006657:Histones / Q000378:metabolism; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D010766:Phosphorylation
D002868:Chromosomal Proteins, Non-Histone; D006609:High Mobility Group Proteins; D006657:Histones; C025301:histone H1 phosphate