Constriction of fetal ductus arteriosus by nonsteroidal antiinflammatory drugs.
Transplacental fetal ductal constriction was studied for 24 NSAIDs in full-term pregnant rats. All 16 acidic NSAIDs constricted the fetal ductus, but considerable differences in the grade of effect were noticed with the clinical doses of each NSAID. Six of the eight basic NSAIDs did not constrict the fetal ductus. It is concluded that acidic NSAIDs should not be administered to pregnant women. However, it may be established in the future that some basic NSAIDs can be administered safely.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004373:Ductus Arteriosus / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005333:Fetus / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects*
D000893:Anti-Inflammatory Agents