Antibody affinity and acute immune complex disease.
The affinity of anti-BSA antibody was measured daily in rabbits with acute immune complex disease. Affinity values increased with time (r = 0.87: p less than 0.01). Antibody affinity before antigen elimination was 5.3 +/- 0.7 X 10(5)M-1 (Mean +/- SEM, n = 19); affinity after antigen elimination was 9.6 +/- 1.4 X 10(5)M-1 (n = 7). (p less than 0.01: Student's t-test). At the time serum creatinine was elevated antibody affinity was low averaging 7.6 +/- 1.24 X 10(5)M-1 (n = 9). These findings support the hypothesis that complexes of low affinity antibody and antigen may participate in acute immune complex injury.
D000818:Animals; D000915:Antibody Affinity; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D003404:Creatinine / Q000097:blood; D007105:Immune Complex Diseases / Q000097:blood / Q000276:immunology*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007457:Iodine Radioisotopes; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000008:administration & dosage
D000936:Antigen-Antibody Complex; D007457:Iodine Radioisotopes; D012710:Serum Albumin, Bovine; D003404:Creatinine