[Role of the kallikrein-kininogen-kinin system in the inflammatory reaction and septic shock].
Kinins, which are vasodilatory, permeability-increasing, pain-producing polypeptides, are formed from inactive precursors: kininogens. Their actions make kinins a particularly powerful potential pro-inflammatory factor. However the absence of specific antagonists has so far made it impossible to ascribe them a definite role in inflammation. Two studies of experimental endotoxemia in burns patients, septicemia and septic shock have demonstrated the following facts: activation occurs of specific ( pKK ) and non-specific (plasminogen-plasmin system) kininogenases , K-HMW and K-LMW levels are significantly decreased. Kininogen consumption corresponds to increased BDK production. This would therefore appear to be one of the humoral factors responsible for haemodynamic changes. Though measurement of kininogen levels is still a painstaking process, the development of chromogenic substrates has made pKK and KK measurement simple and fast. Once they have been validated physico-pathologically in a large number of patients, such assays should take their place among the diagnostic weapons of clinical biology at the disposal of clinicians.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D005174:Factor XII / Q000502:physiology; D005341:Fibrinolysin / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007610:Kallikreins / Q000502:physiology*; D007704:Kininogens / Q000502:physiology*; D007705:Kinins / Q000494:pharmacology / Q000502:physiology*; D012772:Shock, Septic / Q000503:physiopathology*
D007704:Kininogens; D007705:Kinins; D005174:Factor XII; D007610:Kallikreins; D005341:Fibrinolysin
Rôle du système kallikréines-kininogènes-kinines dans la réaction inflammatoire et le choc septique.