IgG-Fc receptors differ in sensitivity to primary amines.
The effect of 12 different amines was tested on the IgG-Fc receptor (IgG-FcR) function of human peripheral mononuclear blood cells (PMBCs). While histamine and to a lesser extent dopamine resulted in a higher ratio of EA-rosette forming cells, a group of amines, like methylamine, dansylcadaverine, hydroxylamine and some others inhibited the EA-rosette formation. Neither the enhancement nor the inhibition was found to be mediated through direct interaction of amines with the Fc portion of the IgG molecule or the IgG-FcR. Only a portion of IgG-FcRs are sensitive to the amine-mediated inhibition and the results suggest that amines inhibit the cluster formation of IgG-FcRs.
D000588:Amines / Q000494:pharmacology*; D001667:Binding, Competitive; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008744:Methylamines / Q000494:pharmacology; D011961:Receptors, Fc / Q000187:drug effects* / Q000378:metabolism; D017452:Receptors, IgG; D012397:Rosette Formation
D000588:Amines; D007074:Immunoglobulin G; D008744:Methylamines; D011961:Receptors, Fc; D017452:Receptors, IgG; D006632:Histamine; C027451:methylamine