title: [Biochemical disturbances in the chronic use of alcohol and ways to correct them].
abstract: It is established in experiments on rats that variations in the activity of alcohol dehydrogenase, catalase, content of nicotinamide enzymes and lipid peroxides may be used as tests to study formation of liking for spirits. Pathways of lithium nicotinate normalizing effect on metabolic disturbances in tissues and the substance possible use as an anti-alcoholic agent are discussed.
mesh_terms: D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000437:Alcoholism / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D002374:Catalase / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008094:Lithium / Q000627:therapeutic use; D009525:Niacin / Q000627:therapeutic use*; D009536:Niacinamide / Q000378:metabolism; D051381:Rats
chemical_list: D008054:Lipid Peroxides; D009536:Niacinamide; D009525:Niacin; D008094:Lithium; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; D002374:Catalase
vernacular_title: Biokhimicheskie narusheniia pri khronicheskom potreblenii alkogolia i puti ikh korrektsii.