title: [Single-dose mezlocillin prophylaxis and postoperative morbidity after vaginal hysterectomy: pharmacokinetic and clinical results].
abstract: In this prospective, randomized study we evaluated the prophylactic administration of 5 g Meclocillin in a single dose. 100 patients undergoing vaginal hysterectomies were observed. Clinical parameters as well as Meclocillin concentrations in serum and myometrium were compared. We found a sufficient Meclocillin concentration in serum and myometrium 30 minutes after intravenous administration. In the control group (n = 50) 8 patients had a febrile postoperative course whereas there was 1 patient only in the treated group. A more detailed analysis regarding predisposing risk factors, urinary tract infections and pathogens of the vaginal wound secretions is presented. The single dose administration had no significant effect on the incidence of postoperative urinary tract infections. The preliminary result of our study reveals the single dose treatment to be a remarkable alternative to the three-dose-perioperative regimen. Regarding the general question of prophylactic antibiotic treatment at time of vaginal hysterectomy especially individual factors as well as preoperative risk factors have to be taken into account.
mesh_terms: D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007045:Hysterectomy, Vaginal / Q000009:adverse effects*; D007263:Infusions, Parenteral; D008802:Mezlocillin; D009215:Myometrium / Q000032:analysis; D010406:Penicillins / Q000008:administration & dosage* / Q000097:blood; D011183:Postoperative Complications / Q000517:prevention & control*; D012306:Risk; D014546:Urinary Catheterization / Q000009:adverse effects; D014552:Urinary Tract Infections / Q000517:prevention & control; D014621:Vagina / Q000601:surgery
chemical_list: D010406:Penicillins; D008802:Mezlocillin
vernacular_title: 1-Dosis-Mezlozillin-Prophylaxe und postoperative Morbidität nach vaginaler Hysterektomie: pharmakokinetische und klinische Ergebnisse.