Analysis of iodochlorhydroxyquin in cream formulations and bulk drugs by high-performance liquid chromatography.
A high-performance liquid chromatographic method for the analysis of iodochlorhydroxyquin in creams and as bulk drugs has been developed. Iodochlorhydroxyquin was acetylated in the 8-position by reaction with acetic anhydride in pyridine. The resulting ester was mixed with the internal standard and chromatographed on a microparticulate silica column. Recovery was quantitative and the method was shown to be applicable to cream formulations from several manufacturers.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D007464:Clioquinol / Q000032:analysis*; D006912:Hydroxyquinolines / Q000032:analysis*; D009824:Ointments / Q000032:analysis
D006912:Hydroxyquinolines; D009824:Ointments; D007464:Clioquinol