Lack of a T-cell dependent subpopulation of macrophages in (dichloromethylene) diphosphonate-treated mice.
In Cl2MDP-osteopetrotic mice, one subpopulation of thioglycollate-induced peritoneal exudate macrophages (M phi) is missing. This subpopulation is precisely the one whose differentiation is known to be dependent on T-lymphocytes, as it is also missing in the athymic nu/nu mice. Cl2MDP-induced osteopetrosis being partially attributable to deficient osteoclastic bone resorption, raises the possibility that this missing M phi subpopulation might represent the precursors of osteoclasts. It is suggested from this work that the interplays between T-cells and M phi, so well known in immunity and inflammation, may also be relevant to osteoclastic differentiation and therefore, to bone remodeling.
D000818:Animals; D001202:Ascitic Fluid; D001842:Bone and Bones / Q000473:pathology; D002454:Cell Differentiation; D004002:Clodronic Acid; D004164:Diphosphonates; D008264:Macrophages / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010022:Osteopetrosis / Q000139:chemically induced / Q000473:pathology*; D013601:T-Lymphocytes / Q000502:physiology*; D013864:Thioglycolates / Q000494:pharmacology
D004164:Diphosphonates; D013864:Thioglycolates; D004002:Clodronic Acid