[Cerebral blood flow and metabolism, and neurologic deficit in an experimental infarction. Application to the study of an ergot derivative].
Both age and hypertension are risk factors for the brain. In the presence of a multiple cerebral infarction as obtained by the intra-carotid injection of sodium arachidonate, Hydergine is capable, in the young and old, hypertensive or normotensive rat, of limiting the extent of the edematous reaction, to prevent the intra-cerebral accumulation of Ca++ ions, and limit the fall in cerebral blood flow, all of these facts resulting in a significant improvement in neuromotor behaviour.
D000367:Age Factors; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002544:Cerebral Infarction / Q000139:chemically induced / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D006973:Hypertension / Q000150:complications; D051381:Rats; D012306:Risk
D004088:Dihydroergotoxine
Débit sanguin, métabolisme cérébral et déficit neurologique au cours d'un infarctus expérimental. Application à l'étude d'un dérivé de l'ergot de seigle.