title: [Active immunization against hepatitis B].
abstract: The efficacy of the hepatitis B vaccine Hevac B Pasteur was assessed in 277 persons over a period of 6 months. HBs antigen of 5 micrograms/dose was administered three times in monthly intervals. Before each vaccination and after 6 months 18 chemical pathology data and a clinical assessment were performed and all important serologic hepatitis markers (anti-HBs, anti-HBc, HBs antigen, HBc antigen, anti-HBe) were determined radioimmunologically. Within two months antibodies against the surface antigen (anti-HBs) had developed in 85.7% of vaccinees. After 6 months 93.1% of vaccines had become seropositive. Within the first two months anti-HBs-positive findings and higher anti-HBs concentrations occurred significantly more frequently (P less than 0.048) in females than in males. These differences had largely disappeared at the follow-up assessment in the sixth month. In contrast, both parameters (seroconversion rate and anti-HBs concentration) were age-dependent. Among vaccines of less than 25 years of age and of more than 35 there were significant differences after 6 months (P less than 0.005). The hepatitis B vaccine of the Pasteur institute can be considered immunogenic and safe.
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D008297:Male; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens; D014765:Viral Vaccines
vernacular_title: Aktive Immunisierung gegen Virushepatitis B.