The effect of prenatal diagnosis on the incidence of Down syndrome in Western Australia.
This paper compares the incidence rates of Down syndrome livebirths in Western Australia during two 5-year periods before and after the advent of prenatal cytogenetic diagnosis. A statistically significant fall in the incidence of liveborn Down syndrome is demonstrated and the relevance of amniocentesis screening is discussed in the light of possible future demographic change.
D000328:Adult; D000649:Amniocentesis; D001315:Australia; D003581:Cytodiagnosis; D004314:Down Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008423:Maternal Age; D011247:Pregnancy; D018566:Pregnancy, High-Risk