UM-X7.1 myopathic hamster heart shows altered calcimedin protein levels.
Cardiac tissue isolated from the UM- X7 .1 myopathic hamster shows decreasing levels of the calcimedin proteins relative to calmodulin. Liver, an unaffected tissue, does not show this decrease. The ratio of the 67K - calcimedin to calmodulin for several ages of heart tissue clearly indicates a progressive loss of the calcimedins which correlates with the cardiomyopathy progression. The loss of the calcimedins may be related to the development of the muscle myopathy.
D000375:Aging; D000818:Animals; D017302:Annexins; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism; D009202:Cardiomyopathies / Q000378:metabolism*; D002846:Chromatography, Affinity; D006224:Cricetinae; D005476:Fluphenazine; D008099:Liver / Q000378:metabolism; D008647:Mesocricetus; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D014059:Tongue / Q000378:metabolism
D017302:Annexins; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D005476:Fluphenazine