Effects of acute administration of 5-methoxy-N,N-dimethyltryptamine upon the latency and duration of post-decapitation convulsions.
The effect of acute administration of rats with the 5-hydroxytryptamine (5-HT) agonist drug 5-methoxy-N,N-dimethyltryptamine on the convulsions released by decapitation was examined. The postsynaptic agonist, 5-methoxy-N,N-dimethyltryptamine, prolonged the latency and duration from the 0.5 mg/kg dose upwards. Methergoline, 2.0 mg/kg intraperitoneally injected immediately prior to 5-methoxy-N,N-dimethyltryptamine, caused some considerable blockade of the effects of the 5-HT agonist on post-decapitation convulsions (PDG's). Long-term p-chloroamphetamine (2x10 mg/kg) and p-chlorophenylalanine (1 x 300 mg/kg) did not antagonise the 5-methoxy-N-N-dimethyltryptamine induced changes of PDC's but, by themselves, prolonged PDC duration. The utility of the 5-methoxy-N,N-dimethyltryptamine-PDC method for studying 5-HT receptor mechanisms may be worth considering.
D000818:Animals; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D008732:Methoxydimethyltryptamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology / Q000503:physiopathology*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000502:physiology*; D013997:Time Factors; D010133:p-Chloroamphetamine / Q000494:pharmacology
D008732:Methoxydimethyltryptamines; D008711:Metergoline; D012701:Serotonin; D010133:p-Chloroamphetamine; D010134:Fenclonine