[Acridine orange inhibition of the ATPase activity of myosin and its fragments].
The cation dye acridine orange (AO) was shown to inhibit ATPase activity of myosin, DTNB-myosin and heavy meromyosin and not to influence that of EDTA-S-1 at low ionic force. The inhibiting effect is concerned with the presence of KCl in solution. The allosteric influence of AO on myosin ATPase activity is discussed and dependence of this effect on charge distribution on the surface of the protein molecule is considered.
D000165:Acridine Orange / Q000494:pharmacology*; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D004228:Dithionitrobenzoic Acid / Q000494:pharmacology; D007700:Kinetics; D015879:Myosin Subfragments / Q000378:metabolism; D009218:Myosins / Q000037:antagonists & inhibitors*; D011817:Rabbits
D015879:Myosin Subfragments; D004228:Dithionitrobenzoic Acid; D000251:Adenosine Triphosphatases; D009218:Myosins; D000165:Acridine Orange
Ingibirovanie ATFaznoĭ aktivnosti miozina i ego fragmentov akridinovym oranzhevym.