Normal suppressor-cell activity in systemic lupus erythematosus. A study on 26 cases.
Suppressor-cell activity of 26 SLE patients suffering from active disease was compared to that of 15 healthy controls. ConA-induced and spontaneous suppression was evaluated. The mitogen-driven proliferation of normal allogeneic cells was significantly impaired by ConA-induced as well as spontaneous suppressor cells. However, no difference in suppressor-cell activity could be demonstrated between SLE patients and controls.
D003208:Concanavalin A / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D003208:Concanavalin A