Effects of neonatal medroxyprogesterone acetate on postnatal sexual differentiation of female rats.
Medroxyprogesterone acetate (MPA), 5 micrograms/g body wt, was given to lactating female rats 1 day after parturition. Group 1 females suckled 10-12 young, with equal numbers of males and females, while Group 2 females each suckled 10 female young. The young were weaned at 21 days of age. Exposure to MPA advanced the day of vaginal opening by 1 day, and increased anogenital distance in Group 2 young. At autopsy between 80 and 100 days of age, the clitoris of Group 2 females was significantly greater than in controls, and ovarian and adrenal weights were reduced.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002987:Clitoris / Q000187:drug effects; D005260:Female; D007774:Lactation; D008297:Male; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012733:Sex Differentiation / Q000187:drug effects*; D013997:Time Factors
D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone