Inhibition by quercetin of the release of density dependent-inhibition of cell growth in RSV-transformed chicken cells.
The expression of src gene in dense cultures of chick embryo fibroblasts (CEF) infected by a thermosensitive mutant (NY68) of RSV released density-dependent inhibition of growth and induced in these cells a large increase in DNA, RNA and protein synthesis. This stimulation of cellular metabolism was abolished in the presence of quercetin. Furthermore, quercetin added to the culture medium also inhibited the stimulation of pp60src kinase due to the expression of transformation.
D000818:Animals; D001358:Avian Sarcoma Viruses; D002472:Cell Transformation, Viral; D002642:Chick Embryo; D003260:Contact Inhibition / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts; D005419:Flavonoids / Q000494:pharmacology*; D009154:Mutation; D015688:Oncogene Protein pp60(v-src); D011494:Protein Kinases / Q000096:biosynthesis; D011794:Quercetin / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D013696:Temperature; D014764:Viral Proteins / Q000096:biosynthesis
D005419:Flavonoids; D014764:Viral Proteins; D012313:RNA; D004247:DNA; D011794:Quercetin; D011494:Protein Kinases; D015688:Oncogene Protein pp60(v-src)