Modulation of IgE response by phytohemagglutinin.
The effect of the administration of phytohemagglutinin (PHA) on the IgE response was studied. RF mice were immunized with OA in aluminum hydroxide gel and PHA was injected 1 or 2 days before the immunization in doses of 80 or 1 microliter. Results show that PHA injected on day -1 induces suppression and PHA administered on day -2 induces some stimulation in the IgE response. This effect is independent of the PHA doses used and does not affect the anti-OA hemagglutinin production.
D000818:Animals; D007115:Immunization Schedule; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007279:Injections, Subcutaneous; D051379:Mice; D010835:Phytohemagglutinins / Q000008:administration & dosage*; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013997:Time Factors
D010835:Phytohemagglutinins; D007073:Immunoglobulin E