EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers.
The quantitative electroencephalogram (EEG) and plasma concentration of the antidepressant paroxetine were monitored in five normal volunteers after a single oral dose of 70 mg paroxetine and placebo. Peak plasma concentration occurred 4-6 h post-dose. Placebo had little effect on the EEG but the effects of paroxetine were statistically significant at 6 h post-dose. The EEG changes after treatment consisted of a decrease in delta and theta activity (less than 8 Hz) and increase in beta activity (greater than 12 Hz). These changes were still evident 72 h after treatment. The EEG profile obtained with 70 mg paroxetine is similar to that reported for other antidepressant 5-HT uptake inhibitors, but dissimilar to the classical, sedative antidepressants.
D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology*; D004569:Electroencephalography; D006801:Humans; D007700:Kinetics; D008297:Male; D017374:Paroxetine; D010880:Piperidines / Q000097:blood / Q000494:pharmacology*
D000928:Antidepressive Agents; D010880:Piperidines; D017374:Paroxetine