Transport of mercury compounds across bimolecular lipid membranes: effect of lipid composition, pH and chloride concentration.
The use of bimolecular lipid membranes (BLM) as model membrane allows the analysis of the transport of mercury compounds across the lipidic barriers of biological membranes. The results of flux measurements show that two mercury compounds--HgCl2 and CH3HgCl--cross the BLM but the overall permeabilities are dependent on the pH of the aqueous media, and are not apparently influenced by the different phospholipid constituents of the bilayers. On the other hand, electrical measurements show that, function of the chemical speciation, the transport of this metal is done essentially in the neutral form.
D001692:Biological Transport / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008051:Lipid Bilayers / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism*; D008627:Mercuric Chloride; D008628:Mercury / Q000378:metabolism*; D008767:Methylmercury Compounds / Q000378:metabolism*
D002712:Chlorides; D008051:Lipid Bilayers; D008563:Membrane Lipids; D008767:Methylmercury Compounds; D008627:Mercuric Chloride; D008628:Mercury; C004925:methylmercuric chloride