[Anemia in renal insufficiency. I--Mechanisms of anemia in patients treated with periodic hemodialysis].
Fifty-two patients with anaemia due to chronic renal insufficiency treated by haemodialysis were divided into three severity groups. Except for bi-nephrectomized patients, none of the usual criteria such as age, sex, cause of the renal disease and duration of dialysis correlated with clinical severity. Kinetic studies showed that the severity of anaemia was unrelated to the degree of haemolysis, haemoglobin function or haemodilution. Stem cells were increased in all cases, irrespective of clinical severity. However, the degree of anaemia closely correlated with the degree of erythropoietic deficiency, as measured by radio-iron kinetics. A qualitative defect (slow release of labelled cells from the bone marrow) was associated with severe quantitative erythroid defect. These data indicate that kinetic studies of erythropoiesis constitute objective methods for measuring clinical severity. They favour the theory which makes a hypothetical inhibitor of differentiation and/or proliferation of erythropoietic precursors the main cause of anaemia.
D000740:Anemia / Q000209:etiology* / Q000503:physiopathology; D004920:Erythropoiesis; D006400:Hematocrit; D006438:Hemodilution; D006461:Hemolysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D006435:Renal Dialysis
L'anémie de l'insuffisance rénale. I--Mécanismes de l'anémie des sujets traités par hémodialyse périodique.