title: Effects of serotonin synthesis inhibition on sleep in hippocampectomized rats.
abstract: In adult rats an anterodorsal bilateral hippocampectomy produced an increase in motor activity without modification of the amount of the different sleep stages. In hippocampectomized rats p-chlorophenylalanine produced an insomnia which can be reversed by 5-HTP. These results show that the insomnia produced by brain serotonin depletion is not a result of the hyperactivity produced by the treatments which cause such depletion.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D010134:Fenclonine / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000096:biosynthesis; D012702:Serotonin Antagonists; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D012702:Serotonin Antagonists; D012701:Serotonin; D010134:Fenclonine