title: Suppression of unprimed T and B cells in antibody responses by irradiation-resistant and plastic-adherent suppressor cells in Toxoplasma gondii-infected mice.
abstract: In the acute phase of Toxoplasma infection, the function of both helper T and B cells was suppressed in primary antibody responses to dinitrophenol (DNP)-conjugated protein antigens. During the course of infection, the suppressive effect on T cells seems to continue longer than that on B cells, since suppression in responses to sheep erythrocytes, a T-dependent antigen, persisted longer than those to DNP-Ficoll, a T-independent antigen. Plastic-adherent cells from the spleens of Toxoplasma-infected and X-irradiated (400 rads) mice had strong suppressor activity in primary anti-sheep erythrocyte antibody responses of normal mouse spleen cells in vitro. These data suggest that the activation of irradiation-resistant and plastic-adherent suppressor cells causes the suppression of both T and B cells in Toxoplasma-infected mice.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects; D001402:B-Lymphocytes / Q000276:immunology*; D002448:Cell Adhesion; D005260:Female; D005362:Ficoll / Q000031:analogs & derivatives / Q000276:immunology; D006386:Hemagglutination Tests; D007116:Immunization, Passive; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007518:Isoantibodies / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000201:enzymology / Q000276:immunology* / Q000528:radiation effects; D014124:Toxoplasmosis, Animal / Q000276:immunology*
chemical_list: C031007:DNP-Ficoll; D007074:Immunoglobulin G; D007518:Isoantibodies; D005362:Ficoll; D007073:Immunoglobulin E