title: Virulence factors of Streptococcus mutans and dental caries prevention.
abstract: Streptococcus mutans possesses the abilities to adhere to pellicle-coated tooth surfaces and to form acids - two characteristics associated with the cariogenicity of this micro-organism. De novo synthesis of insoluble glucan by S. mutans glucosyltransferase from sucrose is essential in the adherence process. Therefore, agents which interfere with the adherence ability of S. mutans would be useful for controlling dental caries. In the present report, we have summarized our recent findings concerning virulence factors of S. mutans and means for prevention of S. mutans-induced dental caries.
mesh_terms: D000268:Adhesiveness; D000371:Agglutination; D000818:Animals; D000906:Antibodies / Q000502:physiology; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control*; D044622:Dental Pellicle; D005936:Glucans / Q000378:metabolism; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007534:Isomaltose / Q000031:analogs & derivatives / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000378:metabolism; D013295:Streptococcus mutans / Q000201:enzymology / Q000378:metabolism / Q000472:pathogenicity*; D013395:Sucrose / Q000378:metabolism; D014774:Virulence
chemical_list: D000906:Antibodies; D005936:Glucans; D011135:Polysaccharides, Bacterial; D013395:Sucrose; D007534:Isomaltose; D005964:Glucosyltransferases; C008189:isomaltulose