Failure of acute changes in prolactin to affect DHEA-S secretion in the human.
To investigate whether acute changes in prolactin secretion affect adrenal androgen secretion, serum prolactin and dehydroepiandrosterone sulfate (DHEA-S) concentrations were determined in seven normal women following the administration of chlorpromazine and L-dopa. The changes in plasma prolactin and DHEA-S concentrations over a four-hour period were compared to those in control experiments in which four of the women received placebo alone. Following the administration of chlorpromazine, plasma prolactin concentrations increased four-fold above pretreatment concentrations, reaching a maximum at 120 minutes. Following L-dopa, plasma prolactin concentrations decreased by greater than 50%, with the nadir noted within 90 minutes. Despite these acute changes in prolactin secretion, plasma DHEA-S concentrations remained unchanged. These results, therefore, strongly suggest that acute changes in prolactin secretion have no affect on adrenal androgen secretion.
D000328:Adult; D002746:Chlorpromazine / Q000494:pharmacology; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007980:Levodopa / Q000494:pharmacology; D011388:Prolactin / Q000097:blood / Q000502:physiology*
D003687:Dehydroepiandrosterone; D007980:Levodopa; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin; D002746:Chlorpromazine; D006854:Hydrocortisone