Defective regulation of erythrocyte autoantibodies in SJL mice.
When SJL mice are hyperimmunized with rat red blood cells (RBC), tolerance to self is readily broken and these animals develop a high autoantibody response to their own RBC. However, these mice also fail to generate those antigen-specific suppressor cells which normally regulate this induced autoantibody response.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D001323:Autoantibodies