Physiological adaptation to the loss of amino acid transport ability.
A strain of Neurospora crassa devoid of constitutive amino acid transport ability can utilize arginine as the sole nitrogen source. Nitrogen starvation, presence of arginine, and mutational inactivation of the general permease are key factors in signaling production of an extracellular enzyme which removes the alpha-amino group from the amino acid.
D000596:Amino Acids / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism*; D001692:Biological Transport; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins / Q000037:antagonists & inhibitors; D009154:Mutation; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism
D000596:Amino Acids; D049990:Membrane Transport Modulators; D026901:Membrane Transport Proteins; D001120:Arginine; D009584:Nitrogen