[Determination of the activity and control of the course of sarcoidosis using bronchoalveolar lavage].
The active stage of sarcoidosis is marked by lymphocyte-rich alveolitis with predominance of helper-T-lymphocytes. 8 patients with sarcoidosis were investigated by bronchoalveolar lavage. Of these patients, 5 proved to have high-intensity and 3 low-intensity alveolitis. It was observed that the total number of helper-T-lymphocytes in the lavage liquid was many times higher than in the patients with low-intensity alveolitis. 4 of the 5 patients with high-intensity alveolitis were treated with prednisone. Parallel to the radiological, functional and clinical improvement, a significant decrease in the absolute number of helper-T-lymphocytes was observed in the lavage liquid, as well as a decrease in the ratio of helper- to suppressor-T-lymphocytes.
D000328:Adult; D001980:Bronchi / Q000378:metabolism*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008171:Lung Diseases / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011650:Pulmonary Alveoli / Q000378:metabolism*; D012507:Sarcoidosis / Q000188:drug therapy / Q000473:pathology*; D006377:T-Lymphocytes, Helper-Inducer
D011241:Prednisone
Aktivitätsbestimmung und Verlaufskontrolle der Sarkoidose mittels broncho-alveolärer Lavage.