Applications of 31P NMR to clinical biochemistry.
In summary, phosphorus NMR presents a well documented, continuous, and noninvasive assay of cell energy metabolism in a variety of body organs. In the form used here, it is appropriate to the study of vascular and genetic diseases of the skeletal tissues of adults and energy-related diseases of the body organs in neonates. Under these conditions, 31P NMR is not an expensive installation, has a small up-keep cost, and one which in our experience can be operated by a college graduate technician with ease. We foresee a significant and generalized application to tissue biochemistry in humans.
D000328:Adult; D000818:Animals; D003573:Cytochrome b Group / Q000172:deficiency; D004734:Energy Metabolism; D005260:Female; D006012:Glycogen Storage Disease Type V / Q000378:metabolism; D006801:Humans; D007383:Intermittent Claudication / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010732:Phosphofructokinase-1 / Q000172:deficiency; D010758:Phosphorus; D005082:Physical Exertion; D051381:Rats
D003573:Cytochrome b Group; D010758:Phosphorus; D010732:Phosphofructokinase-1