[Relation between the iodination of human thyroglobulin and the cleavage of the hormone peptide 26K N-terminal].
At moderate iodination levels (about 20 iodine atoms/mol) human thyroglobulin yields after reduction and alkylation a hormone (T4)-containing N-terminal peptide of 26K. Further iodination of the thyroglobulin in vitro results in the cleavage of this part of the molecule into smaller peptides of 22K and 18K. A precursor-product relationship between the 26K peptide segment and the latter was established by showing an identical N-terminal T4-containing sequence in the 3 peptides. Cleavage of peptide bonds in the 26K segment to give the smaller fragments could possibly be related to the formation of another hormone residue.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D006042:Goiter / Q000378:metabolism; D006801:Humans; D007454:Iodides / Q000378:metabolism; D008970:Molecular Weight; D010446:Peptide Fragments / Q000032:analysis; D010455:Peptides / Q000032:analysis; D013954:Thyroglobulin / Q000378:metabolism*; D013974:Thyroxine / Q000032:analysis
D000596:Amino Acids; D007454:Iodides; D010446:Peptide Fragments; D010455:Peptides; D013954:Thyroglobulin; D013974:Thyroxine
Relation entre l'iodation de la thyroglobuline humaine et le clivage du peptide hormonogénique 26K N-terminal.