Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures.
Three experiments failed to provide consistent evidence for an effect of 2.70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures. Microwave radiation counteracted the hypothermic effects of chlordiazepoxide without altering its antiseizure efficacy. This underscores the dissociation between thermal and pharmacological effects of microwaves.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000528:radiation effects; D002707:Chlordiazepoxide / Q000528:radiation effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D010433:Pentylenetetrazole / Q000494:pharmacology / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000628:therapy*; D013047:Specific Pathogen-Free Organisms / Q000528:radiation effects; D013997:Time Factors
D002707:Chlordiazepoxide; D010433:Pentylenetetrazole