Acute effect of thymoxamine on aqueous humor formation in the epinephrine-treated normal eye as measured by fluorophotometry.
The acute effect of 0.5% thymoxamine and 1% epinephrine on aqueous humor flow was evaluated by fluorophotometry in 25 normal human subjects in a randomized, double-blind, placebo-controlled study. Changes in intraocular pressure, anterior chamber volume, and pupil diameter were also measured. The results of this study indicate that epinephrine alone increases aqueous humor flow by 19% and that thymoxamine in a dose sufficient to produce miosis does not alter this acute effect of epinephrine.
D000867:Anterior Chamber / Q000187:drug effects; D001082:Aqueous Humor / Q000187:drug effects*; D004311:Double-Blind Method; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D005470:Fluorometry; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D013948:Moxisylyte / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects; D011897:Random Allocation
D013948:Moxisylyte; D004837:Epinephrine