The control of mammalian cell proliferation by growth factors, basement lamina, and lipoproteins.
The effect of growth factors such as fibroblast growth factor on the production of a basement lamina by cultured endothelial cells has been investigated. The ability of these cells to grow and differentiate properly correlated with their ability to produce a basement lamina. The effect of such a substrate on the growth, differentiation, and aging of cells in vitro, as well as its use for the long-term culture of either normal diploid cells or tumor cells, is reviewed.
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004727:Endothelium / Q000166:cytology*; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008074:Lipoproteins / Q000494:pharmacology*; D008148:Lovastatin / Q000031:analogs & derivatives*; D009281:Naphthalenes / Q000494:pharmacology; D009474:Neurons / Q000166:cytology; D010455:Peptides / Q000494:pharmacology
D006133:Growth Substances; D008074:Lipoproteins; D009281:Naphthalenes; D010455:Peptides; C012258:mevastatin; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D008148:Lovastatin; D006903:Hydroxymethylglutaryl CoA Reductases