Strain and species differences in the induction of ATPase-deficient hepatic foci by diethylnitrosamine.
Diethylnitrosamine (5 mg/kg) was intraperitoneally administered to rats, mice, guinea pigs and tupaias daily for 3 weeks. After 12 weeks of cessation, focal areas of ATPase-deficiency of hepatocytes appeared only in rats and, to a much lesser extent, in guinea pigs. Female rats were more sensitive than males and Wistar rats were less sensitive than Sprague-Dawley rats. These data show that quantitation of ATPase-deficient foci as a determinant of hepatocarcinogenicity is mainly restricted to the rat species.
D000251:Adenosine Triphosphatases / Q000096:biosynthesis*; D000818:Animals; D004052:Diethylnitrosamine / Q000008:administration & dosage*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D009602:Nitrosamines / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014417:Tupaia
D009602:Nitrosamines; D004052:Diethylnitrosamine; D000251:Adenosine Triphosphatases