[Posttransfusion purpura: identification of a new platelet antigen Leka. A case].
A young female patient with Gardner's syndrome developed post-transfusion purpura. Serological studies demonstrated the presence of an antibody directed not against PlA1 but against a new antigen, Leka. This is the first case of post-transfusion purpura not associated with immunization against the PlA1 antigen. The Leka antigen is present in 98% of the French population. Its absence on platelets from patients with thrombasthenia suggests that it is located on the IIb IIIa platelet glycoprotein complex.
D000328:Adult; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D005736:Gardner Syndrome / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics; D011696:Purpura, Thrombocytopenic / Q000209:etiology* / Q000276:immunology; D065227:Transfusion Reaction
C044561:3a alloantigen, human; D016824:Antigens, Human Platelet; D007519:Isoantigens
Purpura post-transfusionnel: identification d'un nouvel antigène plaquettaire Leka. Une observation.