title: [Treatment of acne vulgaris. Double-blind study of a combination of 5% benzoyl peroxide/2% miconazole (Acnidazil) and tretinoin 0.05%].
abstract: The clinical efficacy and tolerance of a combination of benzoyl peroxide 5% and miconazole 2%, Acnidazil, for the treatment of facial acne vulgaris have been compared with those of tretinoin 0.05% in a double-blind study with 40 patients during 12 weeks. The combination of benzoyl peroxide and miconazole gave improvement in 82% of 22 patients, compared to tretinoin which gave improvement in 50% of 18 comparable patients. The difference is significant. Also, side-effects were significantly less in the benzoyl-miconazole group than in the tretinoin group.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D001585:Benzoyl Peroxide / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008825:Miconazole / Q000008:administration & dosage* / Q000627:therapeutic use; D010545:Peroxides / Q000008:administration & dosage*; D014212:Tretinoin / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D010545:Peroxides; D014212:Tretinoin; D008825:Miconazole; D001585:Benzoyl Peroxide
vernacular_title: Behandlung von Acne Vulgaris. Doppelblind-Studie zwischen einer Kombination 5% Benzoyl-Peroxid/2% Miconazol (Acnidazil) und Tretinoin 0,05%.