T-cell effects on in vitro erythropoiesis: immune regulation and immune reactivity.
Optimal in vitro growth of BFU-E requires factors or burst promoting activities (BPA) in addition to erythropoietin. Our studies suggest that small numbers of DR-haploidentical T cells and monocytes present in plasma clot cultures of peripheral blood mononuclear cells can elaborate a BPA in situ. Various populations of normal T cells can augment or limit this activity. In addition, allosensitized "immune-reactive" T cells can inhibit this activity in both a genetically restricted and nonrestricted manner. With this in mind, it becomes important to consider that inhibition of BFU-E growth growth does not necessarily evoke lymphocytes reactive against BFU-E, but rather lymphocytes that can interfere with regulation of auxiliary cell function. Whether or not faulty immune regulation plays a role in "immune-mediated" aplasia remains to be determined.
D000741:Anemia, Aplastic / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D002455:Cell Division; D002478:Cells, Cultured; D004912:Erythrocytes / Q000166:cytology; D004920:Erythropoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007114:Immunization; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology
D000961:Antilymphocyte Serum; D000949:Histocompatibility Antigens Class II