Mezlocillin in serious surgical infections caused by carbenicillin-resistant bacteria.
Fifty-eight surgical patients suffering from severe bacterial infections caused by mezlocillin-sensitive, carbenicillin and/or gentamicin-resistant bacteria were treated with mezlocillin in 1980. At the end of therapy, the infection had been eliminated in 52 patients; they were cured. The remaining six did not need any additional antibacterial treatment. Sixty-two of the bacterial strains isolated had been eliminated, seven markedly reduced in number and three persisted. No development of resistance or side-effects was observed. A randomized comparative study was conducted at the same time.
D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D002228:Carbenicillin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008297:Male; D008802:Mezlocillin; D008875:Middle Aged; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000209:etiology
D005839:Gentamicins; D010406:Penicillins; D002228:Carbenicillin; D008802:Mezlocillin