Participation of auto-anti-idiotypes in immune complex glomerulonephritis in rabbits.
We report the presence of auto-anti-Id antibodies in the glomerular immune deposits of a rabbit with chronic serum sickness induced by daily i.v. injections of bovine serum albumin. Auto-anti-Id antibodies were also documented in the serum of the same animal during the phase of chronic serum sickness in which immune complex glomerulonephritis develops. These results suggest that auto-anti-Id may normally participate in pathologic reactions and may be one of the mechanisms of potentiation and/or progression of immunopathologic lesions.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002908:Chronic Disease; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology*; D007105:Immune Complex Diseases / Q000209:etiology / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000276:immunology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes; D012710:Serum Albumin, Bovine