Moxalactam penetration of normal and osteomyelitic bone.
The ability of moxalactam, a new cephalosporin, to cross the capillary membrane and enter the interstitial fluid space of normal and osteomyelitic bone in the dog was investigated. Moxalactam was noted to readily traverse the capillary membrane of both normal and osteomyelitic bone. The calculated concentrations of moxalactam in the interstitial fluid space corresponded to the simultaneously obtained serum concentrations determined with a bioassay.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002199:Capillary Permeability / Q000187:drug effects; D002511:Cephalosporins / Q000378:metabolism*; D002513:Cephamycins / Q000097:blood / Q000378:metabolism*; D004195:Disease Models, Animal; D004285:Dogs; D007700:Kinetics; D008433:Mathematics; D009070:Moxalactam; D010019:Osteomyelitis / Q000188:drug therapy*
D002511:Cephalosporins; D002513:Cephamycins; D009070:Moxalactam