Reticulo-endothelial function in glomerulonephritis.
IgG- and C3b-coated erythrocytes were used to investigate splenic Fc-receptor function and hepatic C3b-receptor function by measurements of their blood clearance. Most patients with glomerular disease including those who were HLA, A1, B8, DR3 had normal Fc-receptor function. Occasional individuals with persistent glomerulonephritis had delayed clearance unrelated to disease activity. In rapidly progressive glomerulonephritis, the phenomenon of 'reticulo-endothelial blockade' was confirmed. C3b-receptor function was normal in most patients with persistent glomerulonephritis. A defect in splenic Fc-receptor function hepatic C3b-receptor function is unlikely to underlie persistent glomerulonephritis.
D000328:Adult; D003179:Complement C3b; D004912:Erythrocytes / Q000502:physiology; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D011951:Receptors, Complement / Q000502:physiology; D017463:Receptors, Complement 3b; D011961:Receptors, Fc / Q000502:physiology
D006680:HLA Antigens; D007074:Immunoglobulin G; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D011961:Receptors, Fc; D003179:Complement C3b