Strain differences among inbred mice in protein kinase C activity.
A protein kinase was identified in mouse organs whose activity is strictly dependent on the presence of Ca++ and phosphatidylserine when assayed at pH 6, and thus has the characteristics of protein kinase C. The relative order of specific activities was brain greater than spleen greater than lung greater than heart, an order similar to that found previously for rat organs. Mice from seven strains had the same level of protein kinase C activity, but strain A/J had half as much activity in each organ as did the other strains. F1 hybrid mice resulting from a cross between A/J and BALB/cByJ mice had levels of activity intermediate to the parental strains, indicating additive inheritance of this genetic difference.
D000818:Animals; D001921:Brain / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D007700:Kinetics; D008168:Lung / Q000201:enzymology; D051379:Mice; D008805:Mice, Inbred A / Q000378:metabolism; D008807:Mice, Inbred BALB C / Q000378:metabolism; D008811:Mice, Inbred DBA / Q000378:metabolism; D008815:Mice, Inbred Strains / Q000378:metabolism*; D009928:Organ Specificity; D011493:Protein Kinase C; D011494:Protein Kinases / Q000378:metabolism*; D013045:Species Specificity; D013154:Spleen / Q000201:enzymology
D011494:Protein Kinases; D011493:Protein Kinase C