Physiological dependency between the hypothalamus and the thymus in Wistar rats. II. The neurosecretion level and microstructural changes following para-chlorophenylalanine administration. The differences in DL-5-hydroxy G-3H tryptophane incorporation in the hypothalamus of normal and thymectomized rats.
The experiments were carried out on male Wistar rats, both normal and thymectomized in which the thymus was excised in 12th h of life. 8 weeks later, the animals were administered parachlorophenylalanine [PCPA], i.e. a compound inhibiting tryptophane hydroxylase, in the amount of 200 mg/kg of body weight. The studied hypothalamus preparations, i.e. supraoptical [NSO] and paraventricular nuclei [NPV] revealed an increased level of Gomori-positive neurosecretory material in thymectomized rats when compared to control animals. It was observed that the former rodents manifested an elevated incorporation of the isotope, i.e. DL-5-Hydroxy [G-3H] Tryptophane. The calculations performed by the use of the Gosset's t-test ("Student's") showed that the difference was statistically significant (p less than 0.001).
D006916:5-Hydroxytryptophan / Q000378:metabolism*; D000818:Animals; D010134:Fenclonine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009489:Neurosecretion / Q000187:drug effects*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains / Q000033:anatomy & histology / Q000502:physiology*; D013237:Stereoisomerism; D013495:Supraoptic Nucleus / Q000166:cytology; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology*
C020261:4-chlorophenylalanine methyl ester; D006916:5-Hydroxytryptophan; D010134:Fenclonine