[Inhibition of prostaglandin synthesis by (phenylthio-4 phenylamino)-2 nicotinic acids].
In the rat, (phenylthio-4 phenylamino)-2 nicotinic and [(chloro-4 phenylthio)-4 phenylamino]-2 nicotinic acids inhibit the hypotensive prostaglandin-mediated action of arachidonic acid. They inhibit also the formation from arachidonic acid, of prostaglandin-like substances by chopped rat lungs and of malonaldehyde by rat platelets. They are prostaglandin synthetase inhibitors, three to ten times less active as indomethacin.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008315:Malondialdehyde / Q000097:blood; D009539:Nicotinic Acids / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
D001095:Arachidonic Acids; D009539:Nicotinic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid; D008315:Malondialdehyde; C036733:(phenylthio-4-phenylamino)-2-nicotinic acid
Inhibition de la synthèse des prostaglandines par des acides (phénylthio-4 phénylamino)-2 nicotiniques.