ATPase activities and lipid peroxidation in rat cerebral cortex synaptosomes.
ATPase activities and lipid peroxidation as measured by malonaldehyde formation in rat cerebral cortex synaptosomes depend on the time of incubation of the tissue. ATPase activities decreased but lipid peroxidation activity increased with increasing incubation periods. Effects of catechol- and non-catechol molecules on lipid peroxidation in synaptosomes have been determined. Drugs previously shown to stimulate ATPases inhibited lipid peroxidation. It seems likely that close relationships exist between stimulation of ATPase activities and inhibition of lipid peroxidation.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism*; D013997:Time Factors
D008054:Lipid Peroxides; D008315:Malondialdehyde; D000251:Adenosine Triphosphatases