Bacteria-immune system interactions. IX. Modulation of human and murine cytotoxic reactions by crude lipoteichoic acid extracted from Staphylococcus aureus.
Crude lipoteichoic acid extracts of Staphylococcus aureus (SA-LTA) or Bacillus glogigii (Bg-LTA) inhibited cytotoxic reactions when added at day 0 to human or murine mixed lymphocyte reactions (MLR). The inhibition was dose dependent, and at low Sa-LTA concentrations it did not require reduction of thymidine incorporation into effector lymphocytes. In the murine system, Sa-LTA was a much more potent inhibitor than Bg-LTA. LTAs of both origin also could inhibit cytotoxic reactions when bound to stimulator cells. However, the LTA derivatized stimulator cells were much more inhibitory in the human than in the murine MLR. The inhibition of human cytotoxic reaction by Sa-LTA derivatized stimulator was not associated with a significant reduction of thymidine incorporation in effector cells.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007108:Immune Tolerance; D008070:Lipopolysaccharides; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D010712:Phosphatidic Acids / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D013682:Teichoic Acids / Q000276:immunology*
D008070:Lipopolysaccharides; D010712:Phosphatidic Acids; D013682:Teichoic Acids; C009900:lipoteichoic acid