Fibrinogen and the ultralong-range interaction of human erythrocytes.
Fibrinogen, purified by a new method, does not transmit the ultralong-range interaction of erythrocytes. It can be converted into a transmitter by the addition of a preparation of clotting factors used clinically in the treatment of hemophilia B. It is suggested that the addition of the clotting factors induces a conformational change in fibrinogen, which can then polymerize.
D001779:Blood Coagulation Factors / Q000502:physiology; D004058:Diffusion; D004903:Erythrocyte Aggregation; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D005340:Fibrinogen / Q000502:physiology*; D006801:Humans; D011487:Protein Conformation
D001779:Blood Coagulation Factors; D005340:Fibrinogen