The effects of indalpine--a selective inhibitor of 5-HT uptake--on rat paradoxical sleep.
In order to document the role of monoamines in the reduction of paradoxical sleep by antidepressant drugs, we examined the effect of indalpine , a selective inhibitor of serotonin uptake. Indalpine dose dependently decreased paradoxical sleep and delayed its first appearance. Pretreatment with parachlorophenylalanine markedly decreased the effect of indalpine . In contrast, pretreatment with alpha-methylparatyrosine potentiated the indalpine -induced depression of paradoxical sleep. The results of the study indicate that the increase of extracellular concentration of 5-HT has an inhibitory effect on paradoxical sleep, and this effect is enlarged if catecholaminergic activity is reduced.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000502:physiology; D002395:Catecholamines / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology; D012895:Sleep, REM / Q000187:drug effects*; D019805:alpha-Methyltyrosine
D000928:Antidepressive Agents; D002395:Catecholamines; D008781:Methyltyrosines; D010880:Piperidines; D012702:Serotonin Antagonists; D012701:Serotonin; D019805:alpha-Methyltyrosine; D010134:Fenclonine; C018181:indalpine