Deficiency in suppressor T cell activity in aged animals. Reconstitution of this activity by interleukin 2.
Spleen cells derived from aged (30 mo) C57Bl/6 mice are shown to be deficient in the ability to generate suppressor cell activity in vitro. The addition of IL-2 to cultures containing aged cells restores this function to a large extent.
D000375:Aging; D000818:Animals; D002478:Cells, Cultured; D007376:Interleukin-2 / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
D007376:Interleukin-2