Initial experiments with cyproterone acetate and 1-amino-3-chloro-2-propanol hydrochloride in the male Virginia opossum (Didelphis virginiana).
Cyproterone acetate (CA) was toxic for Didelphis virginiana at a dose range of 22-28 mg/kg IM. A loss of spermatozoal pairing int the cauda epididymidis did not occur until 2 wk after testicular degeneration caused by CA. The isomers of 1-amino-3-chloro-2-propanol hydrochloride (CL 88,236 and CL 88,237) were well tolerated by the opossum at doses up to 30 mg/kg IM. After 8 days of CL 88,236 and CL 88,237 treatment there was no effect on spermatozoal pairing in the cauda epididymidis or on the seminiferous epithelium.
D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D004822:Epididymis / Q000187:drug effects; D008297:Male; D009893:Opossums / Q000378:metabolism*; D012671:Seminiferous Tubules / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects*
D002728:Chlorohydrins; D003272:Contraceptive Agents, Male; C009721:CL 88236; D017373:Cyproterone Acetate; D003534:Cyproterone