title: Antifibrinolytic activity in middle ear effusion.
abstract: No activity of the plasmin and plasminogen activators could be detected in middle ear effusion (MEE). A streptokinase proactivator, which was not plasminogen and markedly enhanced the activation of plasminogen by streptokinase, could be detected. MEE had an apparent inhibitory activity against both thiol protease (papain) and serine proteases (plasmin and trypsin). All these findings indicate that MEE contains unsaturated protease inhibitors and is in a state of predominance of inhibitors over fibrinolytic activity.
mesh_terms: D000933:Antifibrinolytic Agents / Q000032:analysis*; D004792:Enzyme Precursors / Q000032:analysis*; D005122:Exudates and Transudates / Q000201:enzymology*; D005341:Fibrinolysin / Q000032:analysis; D006801:Humans; D010033:Otitis Media / Q000201:enzymology*; D010034:Otitis Media with Effusion / Q000201:enzymology*; D010960:Plasminogen Activators / Q000032:analysis; D011480:Protease Inhibitors / Q000032:analysis; D013300:Streptokinase / Q000032:analysis; D014361:Trypsin Inhibitors / Q000032:analysis
chemical_list: D000933:Antifibrinolytic Agents; D004792:Enzyme Precursors; D011480:Protease Inhibitors; C018663:SK potentiator; D014361:Trypsin Inhibitors; D013300:Streptokinase; D010960:Plasminogen Activators; D005341:Fibrinolysin