title: Mutagen sensitivity of Neurospora meiotic mutants.
abstract: The Neurospora meiotic mutants, mei-1, mei-2, mei-3, and mei-4 were tested for cross sensitivity to mutagens. Mei-2 and mei-3 are sensitive to MMS, gamma-irradiation and histidine. Mei-2 is not sensitive to ultraviolet (UV) at 20 degrees C. Tests with recombinants with crossovers to either side of mei-2 or mei-3 show that these traits are the pleiotropic properties of a single gene which also determines meiotic behavior. The mei-2 gene maps to the right of al-3 on linkage group V. It is not allelic to mus-11. Upon backcrossing, the originally dominant meiotic effect of mei-2 becomes recessive to partially dominant. The histidine sensitivity is recessive.
mesh_terms: D000483:Alleles; D005720:Gamma Rays; D006639:Histidine / Q000494:pharmacology; D006720:Homozygote; D008540:Meiosis / Q000187:drug effects*; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation / Q000528:radiation effects; D009491:Neurospora / Q000235:genetics*; D009492:Neurospora crassa / Q000235:genetics*
chemical_list: D009153:Mutagens; D006639:Histidine; D008741:Methyl Methanesulfonate