[The alcohol-chlorpropamide test. Study and diagnostic value of changes in cutaneous temperature].
In 30 chlorpropamide-alcohol flushers baseline malar temperature was lower, maximal temperature higher and rise in temperature above baseline higher than in 97 non- flushers . A negative correlation between baseline temperature and temperature rise was found in both groups. Temperature rise is inadequate as objective indicator of flush, since its sensitivity and specificity were about 70%, even with a difference of 1.4 degrees C in temperature. The Wilkin index seems to be preferable, but it has a weak positive predictive value. At present, the results of the chlorpropamide-alcohol flush test can only be evaluated on clinical data.
D002747:Chlorpropamide; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D000431:Ethanol; D005145:Face; D005483:Flushing / Q000209:etiology*; D006801:Humans; D011446:Prospective Studies; D012881:Skin Temperature / Q000187:drug effects*
D000431:Ethanol; D002747:Chlorpropamide
Test à l'alcool-chlorpropamide. Etude et valeur diagnostique des variations de la température cutanée.