[Role of dopamine receptors in the mechanism of formation of stress-induced stomach lesions].
Experiments on rats with the use of different exposures to stress (generalized electrization and "social stress") have demonstrated that stimulation of dopamine receptors localized in the central nervous system is one of the reasons for stress-induced gastric lesions, particularly for massive hemorrhages. Stimulation of peripheral dopamine receptors seems to have a gastroprotective action. As judged from the intensity of the effects of the dopamine agonists, apomorphine and L-DOPA, on stress-induced lesions of the gastric mucosa, stimulation of D2- rather than of D1-dopamine receptors is of greater importance in stress.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013276:Stomach Ulcer / Q000209:etiology* / Q000517:prevention & control; D013315:Stress, Psychological / Q000150:complications*; D013469:Sulpiride / Q000627:therapeutic use; D014628:Vagotomy
D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D007980:Levodopa; D013469:Sulpiride; D008787:Metoclopramide; D001058:Apomorphine
Uchastie dofaminovykh retseptorov v mekhanizme vozniknoveniia stressornykh porazheniĭ zheludka.