[Hemodynamic mechanism of the hypotensive action of diuretics and their effect on myocardial hypertrophy in the process of long-term treatment of hypertension].
During 12-week hydrochlorothiazide treatment 16 men suffering from uncomplicated essential hypertension were examined. Hemodynamic parameters were controlled by means of echocardiography. The volume of the circulating plasma was determined by the dye dilution method. There was noted a significant decrease of systolic, diastolic, and the mean BP. During the first days of treatment there was observed a significant reduction of left ventricular end-diastolic and stroke volumes (EDV and SV) as well as minute volume (MV). Heart rate and indices of myocardial pump function did not change. On the 12th week of treatment there was noted a significant increase of EDV, SV, and MV, and total peripheral vascular resistance decreased as compared with the initial level. In 9 (56%) out of 16 patients 15.6 g decrease was observed in left ventricular myocardial mass (LVMM) on the average for the group during the 12th week of treatment. The decrease in LVMM was preceded by the decrease in the maximum intracardiac tension on the 3rd week of treatment which, probably, may serve a prognostic criterion of changes in LVMM in the prolonged treatment with diuretics.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000188:drug therapy* / Q000503:physiopathology; D004232:Diuretics / Q000627:therapeutic use*; D004341:Drug Evaluation; D005665:Furosemide / Q000008:administration & dosage; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000959:Antihypertensive Agents; D004232:Diuretics; D006852:Hydrochlorothiazide; D005665:Furosemide
O gemodinamicheskom mekhanizme gipotenzivnogo deĭstviia diuretikov i ikh vliianii na gipertrofiiu miokarda v protsesse dlitel'nogo lecheniia bol'nykh gipertonicheskoĭ bolezn'iu.