[Biological activity of calf spleen extracts containing a DNAase I inhibitor during irradiation].
The purified calf spleen extract (I fraction CM-cellulose), possessing a highly active natural inhibitor of DNAase I, increases the survival rate of gamma-irradiated animals as opposed to irradiated controls. A possible role of DNAase I inhibitor in the radioprotective effect is discussed.
D000818:Animals; D002417:Cattle; D003037:Cobalt Radioisotopes; D006224:Cricetinae; D003850:Deoxyribonuclease I; D004706:Endodeoxyribonucleases / Q000037:antagonists & inhibitors*; D005720:Gamma Rays; D008297:Male; D008647:Mesocricetus; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013154:Spleen / Q000032:analysis*; D014020:Tissue Extracts / Q000627:therapeutic use*
D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; D014020:Tissue Extracts; D004706:Endodeoxyribonucleases; D003850:Deoxyribonuclease I
Issledovanie biologicheskoĭ aktivnosti selezenochnykh ékstraktov teliat, soderzhashchikh ingibitor DNKazy I, pri obluchenii.