title: [Selected problems in the experimental evaluation of the skin-irritating effect of industrial substances].
abstract: Basing on the determination of ID50 and IT50 after Kligman and Wooding but involving our own modification, the primarily irritating effect of certain industrial substances on experimental animals' and humans' skin was comparatively evaluated. Mutual experimental studies have been carried out in Dermatological Clinics in Leipzig and Rostock and Dermatological Clinic at the Medical Academy of Lódź. The results were found to be generally consistent in humans and animals. Extension of international cooperation and information and results on the determination of industrial substances adverse effects seem to be necessary.
mesh_terms: D000485:Allergens; D000818:Animals; D009783:Dermatitis, Occupational / Q000139:chemically induced* / Q000175:diagnosis; D004353:Drug Evaluation, Preclinical; D004485:Eczema / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007509:Irritants; D011817:Rabbits; D012867:Skin / Q000187:drug effects*; D012997:Solvents / Q000009:adverse effects*
chemical_list: D000485:Allergens; D007509:Irritants; D012997:Solvents
vernacular_title: Wybrane zagadnienia doświadczalnej oceny pierwotnie drazniacego dla skŏry działania substancji przemysłowych.