Nuclear magnetic resonance spectroscopic studies of the interaction of phospholipids with stabilizing lysosome agents.
The interaction between phospholipids and stabilizing lysosome agents such as acetylsalicylic acid (ASA), colchicine (CC), prednisolone (PD), etc., was studied using NMR spectroscopy. The peak intensity of protons arising from these compounds was reduced in liposomes containing lecithin and various agents with a molar ratio of 1:1 in D2O. The reduced percentage of protons in the agents differed due to their molecular structures: ASA was about 20%, CC about 30%, and PD about 100%.
D001241:Aspirin / Q000494:pharmacology; D017438:Bisphenol A-Glycidyl Methacrylate; D003078:Colchicine / Q000494:pharmacology; D007202:Indicators and Reagents; D008081:Liposomes / Q000494:pharmacology*; D008247:Lysosomes / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D014052:Toluidines
D007202:Indicators and Reagents; D008081:Liposomes; D008689:Methacrylates; D014052:Toluidines; D017438:Bisphenol A-Glycidyl Methacrylate; D011343:Procaine; D011239:Prednisolone; C038496:N,N-bis(2-hydroxyethyl)-4-toluidine; D001241:Aspirin; D003078:Colchicine