In vivo electrochemical detection of 5-hydroxyindoles in rat somatosensory cortex: effect of the stimulation of the serotonergic pathways in normal and pCPA-pretreated animals.
Differential pulse voltammetry was used for the detection of 5-hydroxyindoles in the cerebral cortex of rats anaesthetized with urethane. The stimulation of the lateral hypothalamus or of the dorsal raphe nucleus induced a 10-40% increase in the amplitude of the signal. The signal recorded from p-chlorophenylalanine (pCPA)-pretreated animals was much smaller than in normal animals and could be increased by 5-HTP administration. The stimulation of the serotonergic pathways was ineffective in the pCPA-pretreated animals.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001931:Brain Mapping; D001933:Brain Stem / Q000502:physiology*; D004563:Electrochemistry / Q000379:methods; D010134:Fenclonine / Q000494:pharmacology; D007211:Indoles / Q000378:metabolism*; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013003:Somatosensory Cortex / Q000378:metabolism*
D007211:Indoles; C026785:5-hydroxyindole; D012701:Serotonin; D010134:Fenclonine