Cyclosporin A and the immune response to transplantation antigens.
Cyclosporin A (CsA) is a promising new immunosuppressive agent with considerable clinical potential. In addition to its ability to prolong allografts and possibly induce transplantation tolerance, this agent appears capable of selectively affecting different T lymphocyte subpopulations. Thus, Cyclosporin A may not only be a useful drug in clinical transplantation, but it may also become an important immunologic probe allowing the dissection of complex cellular interactions involved in the immune response.
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D006649:Histocompatibility Antigens / Q000276:immunology*; D007109:Immunity / Q000187:drug effects*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D014181:Transplantation Immunology / Q000187:drug effects
D003524:Cyclosporins; D006649:Histocompatibility Antigens