Effect of cyproterone acetate on testis and accessory sex organs of male rat.
A significant reduction in testis, epididymis, seminal vesicles, prostate, and adrenal weight of adult rats was observed after CA treatment (10 mg/animal/day) for 13, 26 and 39 days. Biochemical assay on the epididymis showed a fall in the activities of acid and alkaline phosphatase. A significant fall in citric acid content of seminal vesicle and prostate in experimental animals was noted after CA treatment. Histoarchitecture of accessory sex organs was severely impaired.
D000135:Acid Phosphatase / Q000378:metabolism; D000311:Adrenal Glands / Q000187:drug effects; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D004822:Epididymis / Q000187:drug effects; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013737:Testis / Q000187:drug effects*
D002951:Citrates; D019343:Citric Acid; D017373:Cyproterone Acetate; D003534:Cyproterone; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase