The inhibitory activity of a proline-rich polypeptide (PRP) on the immune response to polyvinylpyrrolidone (PVP).
The effect of PRP on the humoral immune response to PVP was studied. It was found that PRP administered before immunization with PVP360 inhibits the immune response to this antigen. The studies revealed that PRP caused the increase of the activity of an "intrinsic" suppressor cells probably by enlarging the pool of these cells. PRP also increases generation of precursor cells for the "induced" suppressor category. The precursor cells are the targets for PVP25 giving rise to the antigen-specific, "induced" suppressor cells. The mechanism of the inhibitory action of PRP on the immune response to PVP is discussed.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D008970:Molecular Weight; D010455:Peptides / Q000276:immunology* / Q000494:pharmacology; D011205:Povidone / Q000276:immunology*; D055232:Proline-Rich Protein Domains; D011453:Prostaglandins / Q000096:biosynthesis; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D010455:Peptides; D011453:Prostaglandins; D011205:Povidone