Administration of agonistic and antagonistic analogues of LH-RH induce anovulation in Macaca fasicularis.
This study was designed to compare the effects of [N-Ac-D-Trp1,3, D-p-Cl-Phe2, D-Phe6, D-Ala10] (A-LH-RH), an inhibitory analogue, and D-Trp6-LH-RH, an agonist of LH-RH, administered to normally cycling cynomologous monkeys. Animals were divided into three groups (n = 5 each), each group receiving one of the following daily during the first 25 days of the menstrual cycle: 1) 20 micrograms of D-Trp6-LH-RH daily, 2) 1 mg of A-LH-RH, and 3) vehicle. Ovulation was established by serial laparoscopies and serum estradiol measurement. Controls presented normal cycles, as evidenced by ovulation day, luteal phase length and hormone levels. Ovulation was completely inhibited during drug administration in all animals of groups 1 and 2. Luteal phase length of all monkeys that ovulated was normal. The present data, therefore, not only show evidence for a consistent anovulatory effect of agonistic and antagonistic analogues of LH-RH in non-human primates, but also open a new approach for non-steroidal contraception.
D000818:Animals; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008183:Luteal Phase / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D008251:Macaca / Q000502:physiology*; D008252:Macaca fascicularis / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D017329:Triptorelin Pamoate
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; C039243:LHRH,(N)-Ac-Trp(1)-(4-Cl-Phe)(2)-Trp(3)-Phe(6)-AlaNH2(10)-; D007986:Luteinizing Hormone