title: Monoclonal antibodies to human leucocyte antigens in polymyositis and muscular dystrophy.
abstract: Biopsy specimens from patients with treated or untreated polymyositis and muscular dystrophy controls were examined by indirect immunoperoxidase staining with a panel of monoclonal antibodies to human leucocyte antigens. In untreated polymyositis, helper/inducer T cells were the predominant T cell subset. In treated cases few T cells were seen. Overall, few T cells were seen in dystrophic cases, most infiltrating cells being dendritic and lacking T cell antigens. Staining of sarcolemma with anti-HLA class 1 antibody is weak or negative except in areas adjacent to infiltrating leucocytes or where muscle fibre damage is apparent.
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis*; D003882:Dermatomyositis / Q000276:immunology; D005260:Female; D006649:Histocompatibility Antigens / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D009132:Muscles / Q000473:pathology; D009136:Muscular Dystrophies / Q000276:immunology*; D009220:Myositis / Q000276:immunology* / Q000473:pathology; D012508:Sarcolemma / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D006649:Histocompatibility Antigens