Influence of Fusarium and Myrothecium mycotoxins on dehydrogenase activity of Saccharomyces cerevisiae.
The Fusarium and Myrothecium mycotoxins roridin A, diacetoxyscirpenol, verrucarin A, T-2 toxin and zearalenone (10(-2) and 10(-3) mg/ml) inhibit the unspecific dehydrogenase activity of baker's yeast (Saccharomyces cerevisiae) in vivo. The action of these toxins is in the same order as that of aflatoxin B1. It is suggested that at least the trichothecenes decrease the dehydrogenase activity by an interaction with thiol groups of the active center of the enzymes.
D005670:Fusarium; D003904:Mitosporic Fungi; D009183:Mycotoxins / Q000494:pharmacology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D013605:T-2 Toxin / Q000494:pharmacology; D014255:Trichothecenes / Q000494:pharmacology; D015025:Zearalenone / Q000494:pharmacology
D009183:Mycotoxins; D014255:Trichothecenes; D015025:Zearalenone; D010088:Oxidoreductases; D013605:T-2 Toxin; C005348:muconomycin A; C038849:roridin A; C001809:diacetoxyscirpenol