Impaired atropine responsiveness in asthma: role of atopy.
Responsiveness to anticholinergic bronchodilators was assessed in 19 atopic and in 36 non-atopic asthmatics of comparable mean age and basal FEV1. Atopic subjects had a significantly lower degree of responsiveness (p less than 0.01). When the 19 atopic subjects were matched for FEV1 and age with 19 non-atopic subjects (selected from the group of 36) the difference in responsiveness to anticholinergic drugs was still evident (p less than 0.01). Atopic status thus appears to have a significant effect on bronchial reactivity to inhaled anticholinergic drugs.
D000328:Adult; D000368:Aged; D000420:Albuterol / Q000276:immunology; D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D001285:Atropine / Q000502:physiology*; D001286:Atropine Derivatives / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000503:physiopathology*; D009241:Ipratropium / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012882:Skin Tests
D001286:Atropine Derivatives; D001285:Atropine; C006649:methylatropine; D009241:Ipratropium; D000420:Albuterol