Effect of antiandrogens and medroxyprogesterone acetate on testicular morphometry in mice.
Administration to albino mice of cyproterone (C), cyproterone acetate (CA) and medroxyprogesterone acetate (MPA) for one week produced a marked decrease in volume, surface area and length of the seminiferous tubules besides inhibiting spermatogenesis. This response was elicited by all the three treatments but was assessed as mild in "C", moderate in "MPA" and severe in "CA" groups. On the basis of present work it is concluded that inhibition of spermatogenesis occurred even with low dose schedule of the two antiandrogens and MPA. The possible mechanism of action has been discussed in the light of available literature.
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D003534:Cyproterone / Q000031:analogs & derivatives / Q000494:pharmacology; D017373:Cyproterone Acetate; D008297:Male; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D051379:Mice; D008815:Mice, Inbred Strains; D012671:Seminiferous Tubules / Q000187:drug effects / Q000473:pathology; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000473:pathology*
D000726:Androgen Antagonists; D017373:Cyproterone Acetate; D017258:Medroxyprogesterone Acetate; D003534:Cyproterone; D008525:Medroxyprogesterone