The influence of genetic background on the susceptibility of inbred mice to streptozotocin-induced diabetes.
Multiple low-dose injections of streptozotocin (STZ) induce a delayed but progressively increasing state of hyperglycemia in mice. Different inbred strains of mice show different susceptibility to this treatment. We examined whether genetic factors associated with the H-2 complex influence the susceptibility or resistance, using a selected group of 12 inbred and 5 congenic resistant strains of mice. We found that different congenic strains differed significantly in their susceptibility to STZ-induced diabetes, suggesting that H-2-associated genes do influence the susceptibility. However, at least some inbred strains sharing the same H-2 haplotype also differed in their susceptibility, indicating that genes outside the H-2 complex may also affect the susceptibility. Therefore, there appear to be at least two genes, one within and one or more outside the H-2 complex, that determine the susceptibility to multiple low doses of STZ.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000235:genetics*; D004334:Drug Administration Schedule; D006183:H-2 Antigens / Q000235:genetics*; D006238:Haploidy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics; D008809:Mice, Inbred C3H / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics*; D013045:Species Specificity; D013311:Streptozocin / Q000008:administration & dosage
D001786:Blood Glucose; D006183:H-2 Antigens; D013311:Streptozocin