Responses of human bone marrow progenitor cells to fluoro-ara-AMP, homoharringtonine, and elliptinium.
The cytotoxicity of the investigational anticancer drugs fluoro-ara-AMP, homoharringtonine, and elliptinium on normal human granulocyte-macrophage colony-forming units in culture (GM-CFU) was investigated using a bilayer soft agar system. For each drug, the dose-dependent survival curve on a semilogarithmic plot formed a straight line. The D0 were: 0.51 microgram/ml (fluoro-ara-AMP), 0.004 microgram/ml (homoharringtonine) and 0.026 microgram/ml (elliptinium). The in vitro toxicity of drugs on bone marrow progenitor cells did not correlate with the relative myelosuppressive potency observed in vivo.
D000470:Alkaloids / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001088:Arabinonucleotides / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D004611:Ellipticines / Q000494:pharmacology*; D006248:Harringtonines / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D000077863:Homoharringtonine; D006801:Humans; D066298:In Vitro Techniques; D001084:Vidarabine Phosphate / Q000031:analogs & derivatives / Q000494:pharmacology*
D000470:Alkaloids; D000970:Antineoplastic Agents; D001088:Arabinonucleotides; D004611:Ellipticines; D006248:Harringtonines; D001084:Vidarabine Phosphate; C027767:elliptinium; C042382:fludarabine phosphate; D000077863:Homoharringtonine