Influence of streptozotocin- and alloxan-induced diabetes on the crosslinking of dermal collagen.
The influence of experimentally induced diabetes on rat dermal collagen crosslinking was investigated in male albino rats. In comparison to the normal, the diabetic group demonstrated decrease in percent reversibility of neutral salt-soluble collagen gel and susceptibility of insoluble collagen to denaturing agents and pronase whereas the aldehyde content was significantly increased. The electrophoretic gels revealed a marked decrease of alpha/beta ratio in diabetic animals. The results indicated that both the intra- and intermolecular crosslinkings of collagen were increased in experimentally induced diabetes.
D000496:Alloxan; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D046911:Macromolecular Substances; D008297:Male; D051381:Rats; D012867:Skin / Q000378:metabolism*; D012995:Solubility; D013311:Streptozocin
D046911:Macromolecular Substances; D013311:Streptozocin; D000496:Alloxan; D003094:Collagen