[Clinico-experimental study of the possibility of the use of immobilized enzymes for local thrombolysis and thromboformation].
Fibrinolysin immobilized by a solid polysaccharide carrier capable of controllable biodegradation is shown to exert a local effective thrombolyzing action. Certain results of clinical studies of immobilized streptase (streptodecase) are presented. They show essential advantages of the new preparation over the known native enzymes. Experiments with animals show that the immobilized thrombin may be applied in therapeutic embolization for the hemorrhage cessation.
D000818:Animals; D001777:Blood Coagulation; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods; D004800:Enzymes, Immobilized / Q000008:administration & dosage*; D005341:Fibrinolysin / Q000008:administration & dosage*; D006470:Hemorrhage / Q000188:drug therapy; D006801:Humans; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008863:Microspheres; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D013300:Streptokinase / Q000008:administration & dosage*; D013917:Thrombin / Q000008:administration & dosage*; D013927:Thrombosis / Q000188:drug therapy*
D004800:Enzymes, Immobilized; D013300:Streptokinase; D013917:Thrombin; D005341:Fibrinolysin
Kliniko-éksperimental'noe izuchenie vozmozhnostei primeneniia immobilizovannykh fermentov dlia lokal'nogo tromboliza i tromboobrazovaniia.