[Studies with azlocillin, mezlocillin, penicillin-g-potassium and sisomicin on tolerance in the cornea and the kinetics of inhibiting concentrations in the cornea and aqueous humor in rabbits].
We studied the effect of azlocillin, mezlocillin and sisomicin in concentrations of 1, 2.5 and 5% on the regeneration of stromal corneal wounds in rabbits following subconjunctival injections and treatment with eye drops. Concentrations of the antibiotics were also determined in corneal tissue and in aqueous humor and compared with that of penicillin G-potassium. Together with azlocillin, sisomicin proved to be the most effective and the safest. Mezlocillin only inhibited wound regeneration slightly and thus mezlocillin appears to be inferior to the other two antibiotics investigated in the local treatment of the eye.
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis*; D001390:Azlocillin; D003315:Cornea / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D004361:Drug Tolerance; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D008297:Male; D008802:Mezlocillin; D010400:Penicillin G / Q000378:metabolism / Q000494:pharmacology*; D010406:Penicillins / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects; D012853:Sisomicin / Q000378:metabolism / Q000494:pharmacology*
D005839:Gentamicins; D010406:Penicillins; D001390:Azlocillin; D008802:Mezlocillin; D010400:Penicillin G; D012853:Sisomicin
Untersuchungen zur Verträglichkeit an der Cornea und zur Kinetik von Hemmstoffkonzentrationen in Hornhaut und Kammerwasser des Kaninchens mit den Antibiotika Azlocillin, Mezlocillin, Penicillin G-Kalium und Sisomicin.