Effects of synthetic thymosin beta 9 fragments on low E-rosette-forming cells of lupus nephritis patients.
Five fragments from hexapeptide to decapeptide, corresponding to positions 16-25 of thymosin beta 9, were synthesized and their effects on low E-rosette-forming capacity with sheep erythrocytes of cells from lupus nephritis patients were compared with that of the undecapeptide (positions 16-26) of thymosin beta 9 by taking synthetic thymosin beta 9 as a standard. Two of the fragments (16-25 and 18-25) exhibited higher activity than that of the parent peptide (16-26). The other three sequences (17-25, 19-25, and 20-25) had no effect at concentrations as high as 10(-4) M.
D000595:Amino Acid Sequence; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D007202:Indicators and Reagents; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D012397:Rosette Formation; D013577:Syndrome; D013947:Thymosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D007202:Indicators and Reagents; D010446:Peptide Fragments; D013947:Thymosin; C042362:thymosin beta(9)