Anti-acetylcholine receptor antibody in aged individuals and in patients with Down's syndrome.
Anti-acetylcholine receptor (AChR) antibodies were found in 9 of 50 sera from old patients with cerebrovascular disease (CVD) and in 9 of 38 sera from patients with Down's syndrome. Only one of 30 sera from young patients with CVD was positive. There were age-related changes in the positive rate and titers among Down's syndrome subjects. Anti-AChR antibody appeared associated with aging as did other autoantibodies.
D000109:Acetylcholine / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D002561:Cerebrovascular Disorders / Q000276:immunology; D004314:Down Syndrome / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011950:Receptors, Cholinergic / Q000032:analysis / Q000276:immunology*
D001323:Autoantibodies; D011950:Receptors, Cholinergic; D000109:Acetylcholine