Increased IgD milk antibody responses in a patient with Down's syndrome, pulmonary hemosiderosis and cor pulmonale.
IgD antibody responses to cow's milk were investigated in a two-year-old black boy with evidence of pulmonary hemosiderosis and pulmonary hypertension. Initially a broad spectrum of immunologic responses to cow's milk were observed including IgD, IgE, and precipitin antibodies. Specific IgD antibody responses to cow's milk could be modulated in terms of challenge or elimination and correlated with the clinical course. It is possible that IgD antibodies may be important in milk-related pulmonary hemosiderosis.
D000818:Animals; D000917:Antibody Formation; D002675:Child, Preschool; D004314:Down Syndrome / Q000276:immunology; D005512:Food Hypersensitivity / Q000209:etiology; D006486:Hemosiderosis / Q000276:immunology; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis*; D008171:Lung Diseases / Q000276:immunology; D008297:Male; D008892:Milk / Q000009:adverse effects / Q000276:immunology*; D011660:Pulmonary Heart Disease / Q000276:immunology
D007072:Immunoglobulin D