[Diverse action of 17-alpha-hydroxyprogesterone caproate and medroxyprogesterone acetate on the biosynthesis of collagen and cirrhogenous course of CC14-induced hepatic lesions in rats].
The administration of medroxyprogesterone acetate to rats did not induce rapidly progressing cirrhosis in livers damage by carbon tetrachloride, as had occurred after the administration of 17-alpha-hydroxyprogesterone caprate. Even after two months' treatment with medroxyprogesterone acetate and CC14, the cirrhosis did not reach the levels obtained in a single month with the association of 17-alpha-hydroxyprogesterone and CC14.
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology*; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D006908:Hydroxyprogesterones / Q000494:pharmacology*; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D051381:Rats; D011919:Rats, Inbred Strains
D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate; D003094:Collagen; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone
Diversa azione del 17-alpha-idrossiprogesterone capronato e del medrossiprogesterone acetato sulla biosintesi del collagene e sulla evoluzione cirrogena delle lesioni epatiche da CC14 nel ratto.