Persistence of cell-mediated immunity to influenza A virus in mice.
Cytotoxic T-cell (Tc) immunity to influenza A virus in mice persists for at least 2 years. Both T-helper (Th) and Tc cells are present and fully functional in old mice; however, the frequency of memory Tc-cell precursors declines with age.
D000375:Aging; D000818:Animals; D005260:Female; D007111:Immunity, Cellular; D007156:Immunologic Memory; D009980:Influenza A virus / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013997:Time Factors