title: Protein binding to brush borders of enterocytes from the jejunum of the neonatal rat.
abstract: The specific binding of IgG to jejunal brush borders was greatest at acidic pH, at neutral pH no specific binding occurred. Specific binding declined with age-no specific binding occurred in borders from 20-and 24-day-old animals. There was no specific binding of IgG to borders from ileal enterocytes. Human transferrin and bovine serum albumin did not bind specifically to borders. The affinity of binding (-Ka) and the receptors site numbers per border estimated for rat IgG were 18.64 X 10(6) M-1 to 3.53 X 10(6) sites; for human IgG, 25.06 X 10(6) M-1 to 3.30 X 10(6) sites; for bovine IgG, 10.48 X 10(6) M-1 to 2.11 X 10(6) sites and for sheep IgG, 7.26 X 10(6) M-1 to 2.34 X 10(6) sites.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002462:Cell Membrane / Q000276:immunology*; D006863:Hydrogen-Ion Concentration; D007074:Immunoglobulin G; D007583:Jejunum / Q000166:cytology / Q000276:immunology*; D007700:Kinetics; D008871:Microvilli / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000378:metabolism*
chemical_list: D007074:Immunoglobulin G; D017452:Receptors, IgG; D011971:Receptors, Immunologic