The influence of blood transfusions on lymphocyte reactivity in man.
The effect of planned blood transfusion (BT) on lymphocyte reactivity in previously non-transfused uraemic patients has been investigated. A sustained and non-specific decrease in MLR was observed in approximately 60 per cent of the cases. Other patients had only a transient decrease, normal or increased response. Lymphocyte suspensions whose proliferation was reduced after BT suppressed the response of autologous cells taken before BT. Neither pre-BT degree of immune responsiveness nor clinical status of the patients had any influence on this phenomenon.
D001788:Blood Grouping and Crossmatching; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D011446:Prospective Studies; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014511:Uremia / Q000276:immunology* / Q000628:therapy