[Fundamental and clinical studies of piperacillin in the field of obstetrics and gynecology].
We conducted experimental and clinical tests on piperacillin (PIPC), a drug with a broad antibacterial spectrum, and achieved the following results. PIPC exhibited the following rather high therapeutic blood concentrations: 30--60 micrograms/ml at 1 hour after intravenous injection of 1 g of PIPC, 10 micrograms/ml at 2 hours after intravenous injection of 2 g of PIPC, 7.2 micrograms/ml at 1 1/2 hours after the completion of 1 hour dripping infusion of 1 g of PIPC, and 5.6 micrograms/ml up to 4 hours after the completion of 2 hours dripping infusion of 2 g of PIPC. The yield to the various uterine tissues is presented in decreasing order: the highest yield to ovary was about 40--50% of the blood level, followed by the uterine cervical region, portio vaginalis, myometrium and oviduct, the lowest yield, about 25--30% of the blood level was found in endometrium. We conducted a clinical test on 7 patients with infections of the sexual organs and it proved to be excellent in 3, good in 3, and ineffective in 1 case so that the overall efficacy rate was 85.7%. The patient in whom PIPC proved ineffective suffered from an underlying disease, namely the end stage of cervical cancer. One patient suffered from a slight headache but whether this side effect was due to administration of the drug is not clear. Absolutely no abnormal findings during laboratory tests which could be attributed to drug administration were made. Based on the above results, PIPC was judged to be an extremely useful drug in the treatment of infections in the obstetric and gynecological fields.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000188:drug therapy; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy*; D010406:Penicillins / Q000378:metabolism / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy; D010878:Piperacillin; D014599:Uterus / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010406:Penicillins; D010878:Piperacillin