Porokeratosis of Mibelli: benzylhydrochlorothiazide-induced new lesions accompanied by eosinophilic spongiosis.
We observed the course of development of porokeratosis stimulated by benzylhydrochlorothiazide (BHCTh) in normal-appearing skin of a patient with long-standing stable porokeratosis of Mibelli. A 72-year-old Japanese man had had porokeratosis of Mibelli for more than 50 years. During administration of BHCTh for 1 year because of his hypertension, a lichenoid drug eruption developed over the lesions of porokeratosis on the flexor aspects of his legs. Readministration of BHCTh by another physician for 6 months resulted in the occurrence of a similar drug eruption that converted into typical skin lesions of porokeratosis 8 weeks later. Serial microscopic examination suggested that BHCTh administration resulted in eosinophilic spongiosis and cornoid lamella formation, which developed into epidermal changes characteristic of porokeratosis.
D000368:Aged; D003875:Drug Eruptions / Q000473:pathology*; D004802:Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy*; D007642:Keratosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D012867:Skin / Q000473:pathology
D006852:Hydrochlorothiazide; C042169:benzylhydrochlorothiazide