title: Auditory brain-stem responses in infants with Down's syndrome.
abstract: Auditory brain-stem responses to clicks were recorded from 38 infants with Down's syndrome at the ages of 3, 6, and 12 months in an attempt to delineate age-dependent and intensity-dependent latency changes in this population. Comparisons were made with 35 normally developing infants at the same age levels. Significant wave V latency differences were observed between groups for both age and intensity, with the group with Down's syndrome showing, in general, shorter absolute wave V latency values across age and steeper latency functions across intensity. The implications of this study are as follows: (1) latency-intensity curves for normally developing infants will not serve adequately as normative values for infants with Down's syndrome, particularly at the age of 12 months, and (2) cochlear function in infants with Down's syndrome may differ from normal infants by the age of 12 months.
mesh_terms: D000161:Acoustic Stimulation; D001307:Auditory Perception; D004314:Down Syndrome / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D008144:Loudness Perception; D008297:Male; D011930:Reaction Time