[Therapeutic efficacy of human immunoglobulins related to their antibody activity against circulating antigens in children with recurrent infections].
Children suffering from recurrent infections of the upper respiratory tract were treated with injections of human immunoglobulins. In 58 of the 97 patients treated clinical symptoms abated and the results of laboratory tests (serum proteins profile and circulating immune complex levels) returned to normal. A positive correlation was established between the therapeutic effectiveness of the immunoglobulins and their in vitro reaction with serum antigens preexisting to treatment and probably released by the micro-organisms responsible for the infections.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D000937:Antigen-Antibody Reactions; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000276:immunology; D007223:Infant; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000276:immunology / Q000628:therapy*
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007136:Immunoglobulins
Efficacité thérapeutique des immunoglobulines humaines liée à leur activité anticorps contre des antigènes circulants chez des enfants souffrant d'infections récurrentes.