Immunoreactive Cu-SOD and Mn-SOD in lymphocytes sub-populations from normal and trisomy 21 subjects according to age.
Copper and manganese superoxide dismutases (Cu-SOD and Mn-SOD) were measured by radioimmunoassay in B and T lymphocytes and macrophages, in patients with trisomy 21 and in matched controls. In the controls, Cu-SOD was present in greater amounts than Mn-SOD and there were quantitative differences in the distribution in the three cellular sub-populations. In trisomy 21, levels of Cu-SOD were raised, with no change in levels of Mn-SOD, supporting the theory of a gene dosage effect. There were significant positive and negative correlations between age and Cu-SOD levels in controls, and a correlation approaching significance for Mn-SOD. In trisomy 21, there was no correlation between age and Cu-SOD levels, and the only significant correlation for Mn-SOD was for B lymphocytes.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001402:B-Lymphocytes / Q000201:enzymology*; D002469:Cell Separation; D002648:Child; D002675:Child, Preschool; D003300:Copper; D004314:Down Syndrome / Q000201:enzymology* / Q000276:immunology; D005260:Female; D006801:Humans; D008264:Macrophages / Q000201:enzymology; D008297:Male; D008345:Manganese; D013482:Superoxide Dismutase / Q000097:blood*; D013601:T-Lymphocytes / Q000201:enzymology*
D008345:Manganese; D003300:Copper; D013482:Superoxide Dismutase