[Biokinetics of osteotropic radiopharmaceuticals in metabolic osteopathy--comparison of 47Ca and 99mTc-methylene-diphosphonate (MDP)].
Plasma clearance and osseous accumulation rates of 99mTc methylene diphosphonate (MDP) in the lumbar spine were measured in 11 patients with osteoporosis (OP), 7 patients with hyperparathyroidism (HPT), 4 patients with osteomalacia (OM) and in 3 patients (N) who were studied to exclude metabolic bone disease. The findings in 19 patients were compared with the results of 47Ca kinetics. The plasma elimination of 99mTc-MDP during the first hour after application was normal in almost all the patients. The 99mTc-MDP accumulation rates in the lumbar spine were raised in patients with HPT and OM (p less than or equal to 0.01) and normal in patients with OP and N (p greater than 0.05). 47Ca kinetics were disturbed in most of the patients with metabolic bone disease, with minimal deviations in OP. The comparison of 99mTc-MDP accumulation rates with the results of 47Ca kinetics revealed significant correlations with exchangeable bone and soft tissue calcium. The correlations with total calcium turnover and calcium accretion were poor. Only half of the patients had equal results of 99mTc-MDP accumulation rates and bone calcium accretion rates. It is concluded that the 99mTc-MDP uptake by bone is an index of bone metabolism presumably of the organic matrix, whereas 47Ca kinetics represent the mineral metabolism of bone.
D000328:Adult; D000368:Aged; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000378:metabolism*; D002132:Calcium Radioisotopes / Q000097:blood / Q000378:metabolism*; D004164:Diphosphonates / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013667:Technetium / Q000097:blood / Q000378:metabolism*; D013669:Technetium Tc 99m Medronate
D002132:Calcium Radioisotopes; D004164:Diphosphonates; D013667:Technetium; D013669:Technetium Tc 99m Medronate
Biokinetik osteotroper Radiopharmaka bei metabolischen Osteopathien--Vergleich von 47Ca und 99mTc-Methylen-Diphosphonat (MDP).