[Amineptine versus imipramine. Double-blind controlled study].
The antidepressant properties of amineptine and imipramine were compared in a double-blind controlled trial involving 38 patients randomized to one or the other treatment. The results were evaluated globally using three scales of psychiatric assessment: Hamilton's depression rating scale, brief psychiatric rating scale (Pichot, Overall and Gorham) and nursing staff observation scale (N.O.S.I.E.). Statistical analysis of the overall score, individual items and grouped items failed to demonstrate any significant difference between the two drugs for the periods considered. Detailed information is provided on the acceptability of both drugs, particularly as regards the cardiovascular system.
D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D003986:Dibenzocycloheptenes / Q000627:therapeutic use*; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; C011597:amineptin; D007099:Imipramine
Amineptine versus imipramine. Etude contrôlée à double insu.