title: Influence of interferon on C19-steroids in urine of malignant skin melanoma and malignant breast neoplasm patients.
abstract: The paper evaluates the effect of human leukocyte interferon (HLI) in patients with malignant skin melanoma and malignant neoplasm of the breast. HLI was administered intramuscularly in a daily dose of 2 X 10(5) IU 7 days at 8-week intervals over a period of 12 months. The chosen patients were in the surgical stage of the disease, i.e. they had undergone surgical operation on the primary tumor or on the regional lymph nodes T1-3, N0-1, M0. During the HLI treatment the values of C19-steroid metabolites and particularly of Dehydroepiandrosterone (DHA) were established and the following conclusions have been drawn: the application of HLI in a dose of 2 X 10(5) by the described method has an impact on the change of C19 steroid metabolism in terms of normalization.
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000628:therapy / Q000652:urine*; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008545:Melanoma / Q000628:therapy / Q000652:urine*; D012878:Skin Neoplasms / Q000628:therapy / Q000652:urine*; D013256:Steroids / Q000652:urine*; D013997:Time Factors
chemical_list: D007370:Interferon Type I; D013256:Steroids; D003687:Dehydroepiandrosterone