Differentiation markers and accessory function of murine macrophages derived from cultured bone-marrow stem cells.
Murine bone-marrow cells cultured in the presence of colony-stimulating factor from mouse-lung-conditioned medium give rise to macrophages which function as accessory cells in antigen-specific T helper cell induction. Virtually all Ia+ bone-marrow stem cell-derived macrophages express determinants encoded in the I-A subregion. A second set of macrophages bears I-A as well as I-E/C-endoced determinants. The products of the I-A and I-E/C subregion, but not those of the I-J subregion, are involved in T helper cell induction.
D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002478:Cells, Cultured; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008211:Lymphocyte Cooperation; D008264:Macrophages / Q000166:cytology / Q000276:immunology*; D051379:Mice; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000949:Histocompatibility Antigens Class II