Clinical evaluation of combination of cefmetazole and piperacillin in the treatment of infections in patients with acute leukemia.
27 episodes of infection in patients with acute leukemia were treated with combination of cefmetazole and piperacillin. Causative bacteria were isolated in each infection. The patients were treated with 6 g cefmetazole and 15 g piperacillin per day in three divided doses. Among the episodes of infection, 21 (78%) of 27 responded to cefmetazole and piperacillin. Adverse reactions were skin rash in 2 patients, transient elevation of serum glutamic-pyruvic transaminase in 3 patients and elevation of creatinine in 1 patient. Cefmetazole and piperacillin appear to be an effective combination, with acceptable adverse reactions, for the empiric therapy of infection in patients with acute leukemia.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D015311:Cefmetazole; D002511:Cephalosporins / Q000008:administration & dosage*; D002513:Cephamycins / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage* / Q000009:adverse effects; D010878:Piperacillin
D002511:Cephalosporins; D002513:Cephamycins; D010406:Penicillins; D015311:Cefmetazole; D010878:Piperacillin