The antimitotic effect of bromocriptine on human fibroblasts.
The effect of bromocriptine on tritiated thymidine incorporation into nuclei of human fibroblasts has been investigated. A dose--dependent decrease of the labelling index has been found. This observation suggests that the antimitotic action of bromocriptine is a more general phenomenon not restricted to the adenohypophysial cells.
D001971:Bromocriptine / Q000494:pharmacology*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005346:Fibroblast Growth Factors; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology
D010455:Peptides; D001971:Bromocriptine; D005346:Fibroblast Growth Factors; D004247:DNA