Inhibition of in vitro immunosuppressive effects of glucocorticosteroids by a competitive antagonist RU-486.
The 19-nor-steroid RU-486 is an antagonist of glucocorticosteroids acting competitively at the receptor level. Pharmacological and endocrinological studies have already shown that RU-486 is able to reverse glucocorticosteroid effects. The present study shows that RU-486 can counteract the inhibitory effect of glucocorticosteroids in two highly corticoid-sensitive in vitro immune responses: murine in vitro antibody response and human autologous mixed lymphocyte reaction.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects; D003907:Dexamethasone / Q000037:antagonists & inhibitors; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D005938:Glucocorticoids / Q000037:antagonists & inhibitors*; D006462:Hemolytic Plaque Technique; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D015735:Mifepristone; D011965:Receptors, Glucocorticoid / Q000187:drug effects; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects
D004963:Estrenes; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011965:Receptors, Glucocorticoid; D015735:Mifepristone; D003907:Dexamethasone; D006854:Hydrocortisone