title: Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment.
abstract: 20 patients with distal onychomycosis were given daily application of an ointment containing 2% tolnaftate and an ointment containing 20% urea under ODT. Following this, 17 of 20 patients developed onychomalacia and seven of these developed onycholysis 1 or 2 weeks later. The separated nails were cut as short as possible. Similarly to those patients with onychomalacia alone, occlusive dressing technique was continuously performed until the newly developed nails became macroscopically normal and no fungi were observed microscopically (responders). Following treatment, out of 20 patients, 14 responded. 5 patients who had a short course of treatment did not respond. Side-effects such as pain, hemorrhage and infection did not occur.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy; D006229:Hand Dermatoses / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D014009:Onychomycosis / Q000188:drug therapy*; D014047:Tolnaftate / Q000008:administration & dosage*; D014508:Urea / Q000008:administration & dosage*
chemical_list: D009824:Ointments; D014047:Tolnaftate; D014508:Urea