Autoantibodies to platelet glycoprotein IIb/IIIa and to the acetylcholine receptor in a patient with chronic idiopathic thrombocytopenic purpura and myasthenia gravis.
The coexistence of chronic idiopathic thrombocytopenic purpura and myasthenia gravis has been infrequently reported. We report another case and show the coexistence of autoantibodies to the platelet glycoprotein IIb and IIIa complex and the acetylcholine receptor. Autoantibody levels were followed during 8 weeks of treatment with cyclophosphamide, vincristine, and prednisone; the concentration of both autoantibodies fell during treatment but without measureable clinical improvement.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002908:Chronic Disease; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008565:Membrane Proteins / Q000276:immunology*; D009157:Myasthenia Gravis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D010980:Platelet Membrane Glycoproteins; D011696:Purpura, Thrombocytopenic / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*
D001323:Autoantibodies; D006023:Glycoproteins; D007166:Immunosuppressive Agents; D008565:Membrane Proteins; D010980:Platelet Membrane Glycoproteins; D011950:Receptors, Cholinergic