Dogger bank itch. 4. An eczema-causing sulfoxonium ion from the marine animal, Alcyonidium gelatinosum [Bryozoa].
Repeated exposure to the marine bryozoan, Alcyonidium gelatinosum, frequently provokes an eczematous allergic contact dermatitis known as the "Dogger Bank Itch". The dermatitis, representing a severe occupational disease, is especially widely distributed among trawlermen working in the Dogger Bank area in the North Sea. The allergy is shown to belong to the type of cell-mediated hypersensitivity. The hapten has been identified as the (2-hydroxyethyl)dimethylsulfoxonium ion. The isolation, structure determination and synthesis are discussed.
D002013:Bryozoa; D003876:Dermatitis, Atopic / Q000139:chemically induced*; D003877:Dermatitis, Contact / Q000209:etiology; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D006241:Haptens / Q000302:isolation & purification*; D006801:Humans; D008387:Marine Toxins / Q000506:poisoning*; D009861:Onium Compounds / Q000506:poisoning*; D013452:Sulfonium Compounds / Q000276:immunology / Q000302:isolation & purification / Q000506:poisoning*
D006241:Haptens; D008387:Marine Toxins; D009861:Onium Compounds; D013452:Sulfonium Compounds; C033899:2-hydroxyethyl-dimethylsulfoxonium