The proportion of TA, TG, and TM cells in various immunodeficiency and autoimmune disorders.
Patients with various immunodeficiency and autoimmune disorders were examined for the proportions of T cells bearing Fc-IgA, Fc-IgG, and Fc-IgM receptors. These disorders included common variable immunodeficiency, systemic lupus erythematosus, ataxia-telangiectasia, selective IgA deficiency, and the Wiskott-Aldrich syndrome. Abnormal proportions (higher or lower than an interval containing 95% of our normal values) of Fc-IgA receptor-bearing T cells (TA) were found in common variable immunodeficiency, systemic lupus erythematous, ataxia-telangiectasia, and selective IgA deficiency. However, the proportion of T cells bearing Fc receptors did not correlate with their functional activity in in vitro immunoglobulin production assays.
D001260:Ataxia Telangiectasia / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D011961:Receptors, Fc / Q000032:analysis; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000032:analysis*; D013601:T-Lymphocytes / Q000145:classification*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000276:immunology
D007070:Immunoglobulin A; D011961:Receptors, Fc; D017452:Receptors, IgG; D011971:Receptors, Immunologic; C035311:immunoglobulin M receptor