Effect of S-adenosyl-L-homocysteine upon sleep in p-chlorophenylalanine pretreated rats.
S-Adenosyl-L-homocysteine (7 mg/kg), administered to PCPA-pretreated rats, was able to restore normal SWS and PS quantities, as well as circadian rhythms. This effect was at its maximum when SAH was injected 48 h after PCPA (400 mg/kg). These results are discussed in terms of post-synaptic synergetic control by SAH of serotonergic and noradrenergic nerve terminals via the periventricular system and caudal medulla in relation to environmental input.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D004347:Drug Interactions; D010134:Fenclonine / Q000494:pharmacology*; D006710:Homocysteine / Q000031:analogs & derivatives*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012435:S-Adenosylhomocysteine / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*
D006710:Homocysteine; D012435:S-Adenosylhomocysteine; D010134:Fenclonine