title: Nasal absorption of nafarelin acetate, the decapeptide [D-Nal(2)6)]LHRH, in rhesus monkeys. I.
abstract: Nafarelin acetate, [D-Nal(2)6]LHRH, a highly potent superagonist of luteinizing hormone-releasing hormone, was given intranasally to six female rhesus monkeys. Absorption was rapid and very reproducible, with peak levels occurring at 15-30 min and a bioavailability of approximately 2% relative to a subcutaneous dose. The nasal dose response was highly nonlinear. The nonlinearity was apparently associated with the absorption phase, since elimination profiles at all doses were similar.
mesh_terms: D000042:Absorption; D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D007279:Injections, Subcutaneous; D008253:Macaca mulatta; D017274:Nafarelin; D009297:Nasal Mucosa / Q000378:metabolism*; D011863:Radioimmunoassay / Q000379:methods
chemical_list: D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone