[Nicotinamide nucleotides as factors of lipogenesis regulation].
Data are analyzed on a regulatory effect of the redox state of NAD- and NADP-couples (the free NAD+-/NADH, NADP+/NADPH ratios) on certain enzymic links of lipogenesis. A concept is formulated on coordination of the activity of lipogenesis key enzymes by a common signal, supposedly by changes in the NAD+/NADH and NADP+/NADPH values in cytoplasm and mitochondria of the rat liver cells. High values of the NAD- and NADP-couples ratios, activation of the citrate transport from mitochondria to cytoplasm and of enzymic systems supplying lipogenesis with a substrate--acetyl-CoA, reducing equivalents (NADPH) determine the maximal lipid synthesis rate observed in adaptive hyperlipogenesis. The inhibitory action of nicotinamide on lipogenesis is realized at the level of systems providing a high metabolic pool of acetyl-CoA and dehydrogenases, producing NADPH in cytoplasm of liver cells.
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D003593:Cytoplasm / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D005947:Glucose / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats
D002951:Citrates; D005227:Fatty Acids; D009243:NAD; D009536:Niacinamide; D019343:Citric Acid; D009249:NADP; D000105:Acetyl Coenzyme A; D000255:Adenosine Triphosphate; D005947:Glucose
Nikotinamidnye nukleotidy kak faktory reguliatsii lipogeneza.