Sequential treatment of deep leg vein thrombosis with porcine plasmin and low dose streptokinase.
Sequential treatment of deep leg vein thrombosis with porcine plasmin and low dose streptokinase (10,000-20,000 U/h) produces strong systemic fibrinolysis as demonstrated by the sustained decrease of euglobulin lysis time, of thromboplastin time values in percent, fibrinogen and factor V levels. There is a statistically significant negative correlation between thrombolytic results and euglobulin lysis time. Treatment period below 3 days are unlikely to give satisfactory results. Occluded vein segments with an apparent median age of 4 days including thrombi older than 10 days (20% of cases) are cleared with an average chance of 50%. Complete dissolution of all thrombi proximal to the crural veins has been demonstrated in 47/114 = 41.2%, some thrombolytic effects in 31/114 = 27.2% and treatment failure in 36/114 = 31.6%. The data favour laboratory monitoring of thrombolytic therapy.
D000328:Adult; D000368:Aged; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005341:Fibrinolysin / Q000008:administration & dosage / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use*; D013552:Swine; D013924:Thrombophlebitis / Q000188:drug therapy*; D013997:Time Factors
D005343:Fibrinolytic Agents; D013300:Streptokinase; D005341:Fibrinolysin