Effect of combined topical glucocorticoids and ultraviolet B irradiation on epidermal Langerhans cells.
The combined effect of topical glucocorticoids and ultraviolet B (UVB) irradiation on ATPase+ epidermal Langerhans cells in vivo was investigated in the guinea pig model. Glucocorticoids did not significantly enhance the response to UVB radiation, in the dosage range from 90-550 mJ/cm2 of UVB, suggesting that both agents were acting in a similar fashion. The solvent ethanol, however, potentiated the effect of UVB exposure due, at least in part, to increased penetration of the UVB into the epidermis. The recovery of ATPase+ Langerhans cells was significantly slower after high (greater than 165 mJ/cm2) than after more moderate doses (90-145 mJ/cm2) of UVB radiation.
D000251:Adenosine Triphosphatases / Q000032:analysis; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D000431:Ethanol / Q000494:pharmacology; D005938:Glucocorticoids; D006168:Guinea Pigs; D007801:Langerhans Cells / Q000187:drug effects* / Q000201:enzymology / Q000528:radiation effects*; D014466:Ultraviolet Rays
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D000431:Ethanol; D000251:Adenosine Triphosphatases