Presence of IgA-producing cells in rats and mice in relation to microbial status.
The numbers of IgA-producing cells in intestinal mucosa, mesenteric lymph nodes, lungs and bronchial lymph nodes were scored in rats and mice. A statistically significant difference in the scores existed between germ-free and SPF mice and between gnotobiotic and SPF rats. In a group of SPF rats a statistically significant difference in the scores was demonstrated in relation to several bacterial and viral agents.
D000818:Animals; D000830:Animals, Laboratory; D000921:Antibody-Producing Cells / Q000166:cytology* / Q000276:immunology; D005856:Germ-Free Life; D007070:Immunoglobulin A / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000276:immunology; D008168:Lung / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice / Q000276:immunology / Q000382:microbiology*; D008815:Mice, Inbred Strains; D051381:Rats / Q000276:immunology / Q000382:microbiology*; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms
D007070:Immunoglobulin A