Age-dependent changes of the Fc gamma-receptor-mediated functions of human monocytes.
The age-dependent alterations of phagocytosis and age-dependent cell change (ADCC) activity through Fc gamma receptors of human monocyte monolayers using anti-D human IgG-coated 51Cr-labeled human red blood cells were determined. 40 healthy aged subjects of both sexes (age: 60-85 years) and 20 healthy young people of both sexes (age: 18-25 years) were studied. The phagocytosis increased significantly with aging in both sexes, whereas a decrease in ADCC activity was found.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology*; D010587:Phagocytosis; D011961:Receptors, Fc / Q000494:pharmacology*; D017452:Receptors, IgG; D012397:Rosette Formation
D011961:Receptors, Fc; D017452:Receptors, IgG