A case of selective IgM deficiency: isotype-specific suppressor T lymphocytes.
A case of selective IgM deficiency with giant leiomyoma of the stomach in a 66-year-old male is reported. Peripheral blood mononuclear cells from the patient synthesized only a small amount of IgM in the presence of pokeweed mitogen (PWM) in vitro. Co-culture of counterpart lymphocytes from the patient and a disease-free individual revealed that increased activity of IgM-specific suppressor T lymphocytes led to a IgM deficiency in this case.
D000368:Aged; D002478:Cells, Cultured; D004406:Dysgammaglobulinemia / Q000150:complications / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000172:deficiency*; D007136:Immunoglobulins / Q000096:biosynthesis; D007889:Leiomyoma / Q000150:complications / Q000276:immunology*; D008297:Male; D013274:Stomach Neoplasms / Q000150:complications / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007075:Immunoglobulin M; D007136:Immunoglobulins