Effects of serotonin on memory impairments produced by ethanol.
Subjects treated with low or high doses of ethanol demonstrated impaired memory, particularly in tests involving the recall of poorly learned information. Zimelidine, an inhibitor of serotonin reuptake, reversed this ethanol-induced impairment. The serotonin neurotransmitter system may mediate learning and memory in humans and may determine some of the effects of alcohol on higher mental functions.
D000328:Adult; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced*; D011939:Mental Recall / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D015031:Zimeldine
D012702:Serotonin Antagonists; D012701:Serotonin; D015031:Zimeldine; D000431:Ethanol; D001977:Brompheniramine