title: [Treatment in a heparin-induced skin reaction with a low-molecular heparin analog].
abstract: Deep vein thrombosis in the leg and pelvis was seen in a 26-year old woman during the seventh month of pregnancy. 20 days after initial administration of heparin sodium, a local, markedly progressing erythema and induration was observed at the subcutaneous injection sites. The same cutaneous reactions occurred after application of heparin calcium. Following oral anticoagulation treatment with phenprocoumon, the patient was treated towards the end of pregnancy and directly post partum with a low-molecular semisynthetic heparin analogue without any side effects. The skin test again showed good tolerance of another heparin analogue and a low-molecular heparin.
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007866:Leg / Q000098:blood supply; D010388:Pelvis / Q000098:blood supply; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011263:Pregnancy Trimester, Third; D013924:Thrombophlebitis / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; C026210:SSHA; D006493:Heparin; D002807:Chondroitin; D002809:Chondroitin Sulfates
vernacular_title: Behandlung bei heparin-induzierter kutaner Reaktion mit einem niedermolekularen Heparin-Analog.