Exercise-induced pulmonary hemorrhage in exercising Thoroughbreds: preliminary results with pre-exercise medication.
Thoroughbreds with a confirmed history of exercise-induced pulmonary hemorrhage (EIPH) were treated pre-exercise with atropine sulfate, cromolyn, ipratropium or furosemide. Atropine prevented EIPH in 3 of 3 trials in 1 horse, while having no significant effect on bleeding status in the other 2 horses. Pre-exercise treatment with cromolyn had no significant effects in the 3 horses. Pre-exercise treatment of ipratropium was apparently responsible for preventing EIPH in 17 out of 18 trials in 2 horses. The pharmacologic properties of ipratropium in the horse have not been studied, but based on human investigation it seems most probable that its bronchodilator effects are responsible for preventing EIPH in the 2 horses. Furosemide administered in different dosages and time intervals prior to exercise did not prevent EIPH in these 3 horses.
D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D001993:Bronchodilator Agents / Q000627:therapeutic use; D004205:Cromolyn Sodium / Q000627:therapeutic use; D005665:Furosemide / Q000627:therapeutic use; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control / Q000662:veterinary*; D006734:Horse Diseases / Q000209:etiology / Q000517:prevention & control*; D006736:Horses; D009241:Ipratropium / Q000627:therapeutic use; D008171:Lung Diseases / Q000209:etiology / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D005082:Physical Exertion
D001993:Bronchodilator Agents; D001285:Atropine; D005665:Furosemide; D009241:Ipratropium; D004205:Cromolyn Sodium