title: [Ulcer-protective effect of cimetidine and an antacid. Animal experiment study on an ulcer model with protracted histamine liberation].
abstract: The ulcer-protective effect of cimetidine has been compared with that of an antacid (Solugastril) containing aluminium hydroxide and calcium carbonate. Ulcers have been produced by using dialysis sacks containing histamine. This model corresponds to stress ulcers observed in risk patients. Both cimetidine and the antacid were capable of inhibiting the ulcer development in corresponding doses and applications: The present results show that an antacid might be qualified for the treatment of stress ulcers in the human therapy.
mesh_terms: D000818:Animals; D000863:Antacids / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006632:Histamine / Q000633:toxicity; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D000863:Antacids; D002927:Cimetidine; D006632:Histamine
vernacular_title: Ulkusprotektive Wirkung von Cimetidin und einem Antazidum. Tierexperimentelle Studie an einem Ulkusmodell mit verlangsamter Histamin-Freisetzung.