A selective effect upon IgG synthesis by T gamma lymphocytes and their products in man.
Depletion of T lymphocytes possessing receptors for IgG (T gamma cells) from peripheral blood lymphocytes (PBL) results in enhanced pokeweed mitogen (PWM)-induced IgG synthesis and secretion as compared to IgM. Concanavalin A (Con A) stimulation of T gamma cells causes release of soluble mediators able to suppress immunoglobulin synthesis by PWM-activated PBL. Such factors cause concentration-dependent selective suppression of IgG synthesis. The mediators act upon T gamma cell-depleted lymphocyte populations, also preferentially suppressing the IgG PFC response while leaving the IgM response relatively intact. Thus T gamma cells and their products selectively affect IgG synthesis in vitro.
D002478:Cells, Cultured; D003208:Concanavalin A / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis; D011043:Pokeweed Mitogens / Q000276:immunology; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000187:drug effects / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011043:Pokeweed Mitogens; D017452:Receptors, IgG; D011971:Receptors, Immunologic; D003208:Concanavalin A