[Electron microscopic study of the depolymerization process on unstabilized fibrin as affected by urea or monochloracetic acid].
With the help of the electronmicroscopic method the non-stabilized fibrin depolymerization has been studied. It has been established that under the action of urea or monochloridacetic acid the gradual transition of fibril clot's structure in globular fibrinolike material takes place. These globules have morphological likeness with the fibrin-monomer molecules and have analogy of the morphological properties to the non-stabilized fibrin dissolution products by complex compounds of heparin. The elimination of urea or monochloridacetic acid from media gives possibility to reconstruct the fibrillar fibrin structure.
D000085:Acetates / Q000494:pharmacology*; D004347:Drug Interactions; D005337:Fibrin / Q000494:pharmacology*; D005340:Fibrinogen / Q000494:pharmacology; D005341:Fibrinolysin / Q000494:pharmacology; D006801:Humans; D008854:Microscopy, Electron; D012995:Solubility; D013917:Thrombin / Q000494:pharmacology; D014508:Urea / Q000494:pharmacology*
D000085:Acetates; C006972:chloroacetic acid; D014508:Urea; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin; D005341:Fibrinolysin
Elektronno-mikroskopicheskoe izuchenie protsessa depolimerizatsii nestabilizirovannogo fibrina pri deĭstvii mocheviny ili monokhloruksusnoĭ kisloty.