[Levels of glutathione and anaerobic glycolysis in the kidney and liver of rats treated with chloroethanol].
Chloroethanol administration produces in rats a strong fall of glutathione levels in liver and kidney tissues. In liver, such a modification does not imply alterations in the levels of glucose, glucose-6-phosphate, fructose-6-phosphate, fructose-1,6-biphosphate, lactate and pyruvate and in the glycolytic activity. In kidney, the glycolytic activity does not result modified, while it appears a reduction in levels of glucose, glucose-6-phosphate, fructose-1,6-biphosphate and triose phosphates and a remarkable increase of pyruvate. The administration of chloroethanol produces a strong fall of glutathione in the soluble and nuclear fractions of liver and in the soluble and mitochondrial fractions of kidney.
D000693:Anaerobiosis; D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D005023:Ethylene Chlorohydrin / Q000494:pharmacology*; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D006593:Hexokinase / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism*; D008297:Male; D010732:Phosphofructokinase-1 / Q000378:metabolism; D051381:Rats
D002728:Chlorohydrins; D007773:Lactates; D019344:Lactic Acid; D005023:Ethylene Chlorohydrin; D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D010732:Phosphofructokinase-1; D005634:Fructose-Bisphosphate Aldolase; D005978:Glutathione
Livelli di glutatione e glicolisi anaerobia nel rene e nel fegato di ratti trattati con cloroetanolo.