title: Artificial donor insemination: analysis of 149 cases at North Carolina Memorial Hospital.
abstract: We analyzed 149 cases of artificial insemination with donor semen at North Carolina Memorial Hospital, Chapel Hill, to study its effectiveness. An overall pregnancy rate of 62.1% was achieved. Based on the mean monthly fecundity rate, the average monthly pregnancy rate was 16.5%, and the cumulative pregnancy rate after three, six, and ten cycles was, respectively, 40.3%, 68.5%, and 95.5%. A uniform evaluation of the women and correction of any treatable female factors before insemination contributed to a high success rate. Diagnostic laparoscopy after three to four failed insemination cycles yielded a high percentage of abnormal findings. These data suggest that almost all properly screened patients will conceive if allowed to undergo a sufficient number of inseminated cycles and that this procedure is a highly effective alternative means of circumventing male infertility.
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000367:Age Factors; D002582:Cervix Mucus; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007315:Insemination, Artificial; D007316:Insemination, Artificial, Heterologous; D010535:Laparoscopy; D008297:Male; D010060:Ovulation; D011247:Pregnancy