Left ventricular changes resulting from chronic aortic regurgitation in dogs.
Chronic aortic regurgitation (AR) was induced by aortic valve perforation using catheterization techniques in 7 closed-chest puppies. Approximately 2 years after the creation of AR in these puppies, their growth was similar to that in littermate controls. A gradually progressive degree of left ventricular (LV) dilation and hypertrophy occurred as LV end-diastolic volume (average 116%) and mass (average 114%) increased in animals with AR compared with that in the littermate controls. The technique described to induce AR did not interfere with the normal growth and development of the animals, and permitted study of the functional characteristics of the resulting LV dilation and hypertrophy without added effects of thoracotomy and pericardiotomy.
D000818:Animals; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000503:physiopathology*; D002306:Cardiac Volume; D006332:Cardiomegaly / Q000209:etiology*; D004285:Dogs; D013318:Stroke Volume