Prevention of cerebral malaria by adoptive transfer of malaria-specific cultured T cells into mice infected with Plasmodium berghei.
Murine T cell populations specific for Plasmodium berghei parasites were generated in vitro from BALB/c immune lymph node cells. The malaria-specific T lymphocytes were shown: a) to proliferate specifically in vitro in response to stimulation with P. berghei-infected red blood cells; b) to exhibit the Thy-1+, Lyt-1+2- cell surface phenotype; c) to provide specific helper activity for an in vitro anti-hapten (TNP) plaque-forming cell antibody response; and d) to protect P. berghei-infected mice from early mortality due to cerebral malaria.
D000818:Animals; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D004912:Erythrocytes / Q000276:immunology / Q000469:parasitology; D005260:Female; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000166:cytology; D008213:Lymphocyte Activation; D008288:Malaria / Q000150:complications* / Q000276:immunology / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010641:Phenotype; D010962:Plasmodium berghei / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology