[Effect of an aromatic retinoid on human squamous cell carcinomas in vitro].
After in vitro incubation of human squamous cell carcinomas of the head and neck region with aromatic retinoid an increased number of lysosomes can be observed in the tumor cells. It is discussed whether this accumulaion of lysosomes is due to a direct stimulation of lysosomal enzyme synthesis or whether it is consequence of cell damage by the retinoid.
D000135:Acid Phosphatase / Q000378:metabolism; D017255:Acitretin; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy*; D008247:Lysosomes / Q000187:drug effects; D009062:Mouth Neoplasms / Q000188:drug therapy*; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014212:Tretinoin; D000135:Acid Phosphatase; D017255:Acitretin
Wirkung eines arosmatischen Retinoids auf menschliche Plattenepithelkarzinome in vitro.