Patency of the ductus arteriosus after balloon dilatation: an experimental study.
Balloon dilatation of the ductus arteriosus was carried out in vivo in newborn pigs and on postmortem specimens from humans and piglets. The ductus was functionally closed in all newborn animals but patency resulted in all animals after balloon dilatation. Left-to-right shunts of 50% to 70% were found with anatomic lumen sizes of 3 to 5 mm. Patency was demonstrated up to 6 weeks after dilatation. Histologic examination showed splitting of the internal elastic layer and media, areas of hemorrhage confined to the media, and preservation of the adventitia. Mediastinal hemorrhage did not occur. This new technique is useful as an animal model of patent ductus arteriosus and could theoretically be used for palliative treatment of ductus-dependent congenital heart disease.
D000800:Angioplasty, Balloon; D000818:Animals; D004195:Disease Models, Animal; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D006330:Heart Defects, Congenital / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D011651:Pulmonary Artery / Q000473:pathology; D011859:Radiography; D013552:Swine