[Part I. Theory and computer simulation for cerebrospinal infusion].
A pharmacokinetic one-compartment model for the cerebrospinal infusion for the brain tumor chemotherapy is described together with various parameters used for computer simulation. An antitumor protein, neocarzinostatin (NCS) as a prototype drug, has been utilized since it was found effective against glioblastoma cells at extremely low concentration (less than 5 ng/ml) and it is readily inactivated by serum. A very slow infusion velocity was found necessary for an appropriate dose regimen; for example, 0.25mg of the drug should be infused into CSF for about 40 min to attain a drug level of 8 ng/ml.
D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002460:Cell Line; D003201:Computers; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D009353:Zinostatin / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D009353:Zinostatin