Acylureido penicillins in neonatal intensive care. Preliminary communication.
The antimicrobial sensitivity of 232 bacteria isolated from patients in a newborn intensive care unit was tested. Practically all organisms were sensitive to a combination of mezlocillin-aminoglycoside; a few were resistant to azlocillin-aminoglycoside. Eighteen patients, all severely ill, were treated with the combination acylureidopenicillin-aminoglycoside. Nine patients died, eight due to non-infectious diseases and one very small premature baby due to Serratia marcescens meningitis. The other patients showed good clinical improvement. The only side-effect observed was a macular rash in one patient.
D001390:Azlocillin; D001424:Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D008802:Mezlocillin; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000627:therapeutic use*
D010406:Penicillins; D001390:Azlocillin; D008802:Mezlocillin