Immunoelectron microscopy related to T-cell monoclonal surface antigen in mycosis fungoides.
For the purpose of diagnosing and staging cutaneous T-cell lymphoma, the nuclear contour index and subsets of T-cells in the lesions were studied. Nuclear contour index measured in T-cells identified precisely with monoclonal pan-T antibody was found to be higher than nuclear contour index measured in T-cell-like cells with significant nuclear convolution. Nuclear contour index increased as the disease progressed from erythematous to tumor stage or to the Sézary syndrome. The relative ratio of suppressor cytotoxic T-cells to helper T-cells was higher in the early rather than late stage of cutaneous T-cell lymphoma.
D000911:Antibodies, Monoclonal / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface / Q000276:immunology; D002467:Cell Nucleus / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D012867:Skin / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface