[Immunologic detection and in vitro activity of suppressor cells].
Suppressor cells can be identified in vitro either by specific antibodies or by functional test assays. On investigation of the latter, a close relationship was demonstrated between spontaneously active and in vitro induced (ConA) suppressor cells. The activity of these cells, however, showed a wide day to day variation. Hence, no clinically relevant conclusions could be drawn from a comparison of patients and controls. This was shown both for SLE and myeloma. However, in multiple myeloma indirect evidence of increased activity of short-lived suppressor cells emerged from a different methodological approach. Helper and suppressor cells were evaluated using monoclonal antibodies. Patients with Hodgkin's disease in long-term remission had decreased proportions of T-lymphocytes. Helper T-cells but not suppressor T-cells were strongly diminished. The helper-suppressor ratio was changed from 2.1 in controls to 1.2 in patients. The stimulation (PHA-stimulation) index of the patients was half of the control value. The interactions of suppressor and tumour cells were investigated in non-Hodgkin's lymphoma. In general, a marked reactive infiltration of neoplastic lymph nodes was found. The pattern of suppressor cell distribution argued in favour of a functional role of these cells in tumour growth.
D000328:Adult; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000276:immunology; D009101:Multiple Myeloma / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
Immunologischer Nachweis und In-vitro-Aktivität von Suppressorzellen.