The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients.
The sensitizing potential of seven industrial antimicrobial agents was evaluated using the guinea-pig maximization test. Preventol O extra (o-phenylphenol) did not produce a sensitization reaction. Preventol ON extra (sodium salt of o-phenylphenol), Preventol GD (dichlorophene) and Proxel XL and HL containing 1,2-benzisothiazolin-3-one were weak sensitizers, while Preventol CMK and Preventol L, both containing chlorocresol, were classified as extreme potential sensitizers. Both the weak and the extreme experimental sensitizers are occasional human sensitizers. The interpretation of the test results is discussed.
D000818:Animals; D009783:Dermatitis, Occupational / Q000209:etiology*; D004485:Eczema / Q000139:chemically induced*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007509:Irritants; D008669:Metallurgy; D010328:Patch Tests; D010575:Pesticides / Q000633:toxicity*; D010636:Phenols / Q000633:toxicity*; D013844:Thiazoles / Q000633:toxicity*
D007509:Irritants; D010575:Pesticides; D010636:Phenols; D013844:Thiazoles