The neurite-promoting effect of fibroblast growth factor on PC12 cells.
Treatment of PC12 cells with fibroblast growth factor(s) from either brain or pituitary caused neurite outgrowth comparable to that produced by nerve growth factor. The neurite outgrowth was preceded by a substantial rise in the activity of ornithine decarboxylase.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000494:pharmacology*; D009414:Nerve Growth Factors / Q000494:pharmacology; D009474:Neurons / Q000166:cytology*; D009955:Ornithine Decarboxylase / Q000096:biosynthesis; D010455:Peptides / Q000494:pharmacology*; D010673:Pheochromocytoma / Q000473:pathology*; D051381:Rats
D006133:Growth Substances; D009414:Nerve Growth Factors; D010455:Peptides; D005346:Fibroblast Growth Factors; D009955:Ornithine Decarboxylase