The modulation of murine immune responses by methyl-B12.
We examined the effect of methyl-B12 on the immune system. As a result, it was revealed that methyl-B12 enhanced antibody production in the in vitro system and that this activity was the strongest with methyl-B12 among the homologues of B12 examined, being nearly as strong as that of Levamisole. It was also revealed that methyl-B12 can exert an enhancing activity on the induction of suppressor T cells Con A. These facts suggest that methyl-B12 has a therapeutic effect against spontaneous incidence of diseases in NZA/W mice. These immunomodulative activities of methyl-B12 and their therapeutic significance against immune disorders were discussed.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000276:immunology; D002470:Cell Survival / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006462:Hemolytic Plaque Technique; D007978:Levamisole / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D011507:Proteinuria / Q000188:drug therapy; D012756:Sheep; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D003208:Concanavalin A; D007978:Levamisole; C019476:mecobalamin; D014805:Vitamin B 12