title: Passive transfer of the idiotypically suppressed state by serum from suppressed mice and transfer of suppression from mothers to offspring.
abstract: Mice that are suppressed with respect to an idiotype (CRIA) present in A/J anti-p-azophenylarsonate antibodies, hyperimmunized, and allowed to rest were previously found to possess high concentrations of suppressor T cells with anti-idiotypic receptors. We have now observed that the sera of such mice contain soluble factors that can selectively suppress the CRIA component of a humoral response when passively transferred to adult or neonatal recipients. When T cells from suppressed, hyperimmunized mice were transferred into female mice before mating, their offspring, upon immunization, produced anti-Ar antibodies that lacked CRIA. A state of idiotypic suppression was also produced in offspring when the mother was inoculated with serum from suppressed mice a few days before parturition. The results indicate that the suppressor factor is not an immunoglobulin.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D007130:Immunoglobulin Idiotypes