[Participation of the IgE receptor in the toxicity of blood platelets against schistosomes].
Human blood platelets, incubated with the serum from patients with schistosomiasis or allergic asthma, became cytotoxic for schistosome larvae, in an allergen-specific mechanism linked to surface bound IgE on platelets. Cytotoxic factors, among which oxygen metabolites might be involved, were able to kill schistosomula through platelet-retaining filters. Flow cytometry showed that platelets bearing IgE receptors represented a subpopulation, the percentage of which significantly increased in patients with high levels of circulating IgE.
D001249:Asthma / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005434:Flow Cytometry; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D010100:Oxygen / Q000378:metabolism; D017455:Receptors, IgE; D011971:Receptors, Immunologic / Q000502:physiology*; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000276:immunology*
D017455:Receptors, IgE; D011971:Receptors, Immunologic; D007073:Immunoglobulin E; D010100:Oxygen
Participation du récepteur pour l'IgE à la toxicité des plaquettes sanguines contre les schistosomes.