[Age-related changes in the immune response of mouse (CBA x C57BL)F1 hybrids. II. Effect of hydrocortisone on the specific immunosuppression phenomenon and the role of nonspecific suppressor cells in the antibody formation process in old animals].
The effect of hydrocortisone on the phenomenon of specific immunosuppression and on antibody formation was studied in old mice. The decrease of immune response in the old CBA X C57BL F1 mice appears to be due to a high suppressive activity of cells-regulators which are accumulated in the spleen with senescence. It is suggested that these cells-suppressors belong to the population of non-specific T-cells sensitive to hydrocortisone. The effector T-cells-suppressors participating in specific suppression of the immune response to sheep erythrocytes in young CBA X C57BL F1 mice are resistant against hydrocortisone.
D000375:Aging; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000937:Antigen-Antibody Reactions; D003433:Crosses, Genetic; D006854:Hydrocortisone / Q000276:immunology*; D007108:Immune Tolerance / Q000187:drug effects*; D007116:Immunization, Passive; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D008808:Mice, Inbred CBA / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D006854:Hydrocortisone
Vozrastnye izmeneniia v immunnom otvete mysheĭ (CBA x C57BL)F1-gibridov. II. Vliianie gidrokortizona na fenomen spetsificheskoĭ immunosupressii i rol' nespetsificheskikh kletok supressorov v protsesse antitelogeneza u starykh zhivotnykh.