[Immunological examinations in dilated cardiomyopathies].
Immunological data in dilated cardiomyopathies can differentiate the nosology of these diseases. In nearly one half of these dilated cardiomyopathies, binding of immunoglobuline in myocardial structures (biopsies) can be demonstrated. By immunohistological techniques collagen I in myocardial biopsies has been predominantly shown. In lymphocytes of the diseases patients the T-cell-suppressor activity is low. This phenomenon seems to play an important role in the pathogenesis of dilated cardiomyopathies and can explain numerous humoral immunological findings. As conclusion the hypothesis can be drawn: several cases of dilated cardiomyopathies and myocarditis can be regarded as different stages of a single underlying disease, in which a low T-cell-suppressor activity seems to act as a predisposing factor.
D000917:Antibody Formation; D006332:Cardiomegaly / Q000150:complications / Q000276:immunology*; D009202:Cardiomyopathies / Q000150:complications / Q000276:immunology*; D003094:Collagen / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D009205:Myocarditis / Q000276:immunology; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D011971:Receptors, Immunologic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007136:Immunoglobulins; D011971:Receptors, Immunologic; D003094:Collagen
Immunologische Untersuchungsbefunde bei dilativen Kardiomyopathien.