[Plea for monoamine oxidase inhibitors. Retrospective study of 350 cases].
The case-records of 350 outpatients treated with monoamine oxidase inhibitors have been reviewed. All patients presented with depression, obsessions or phobias. About two-thirds benefited from the drugs, particularly after other treatments (including psychotropic drugs, seismotherapy, psychotherapy and internment) had failed. With the moderate doses administered (iproniazide: 50 mg/day; nialamide: 100 mg/day) side-effects were uncommon and mild and no incident was noted in 32 general anaesthesias given for surgical operations. These findings should help in lifting the ban on this category of drugs. Monoamine oxidase inhibitors are effective, useful and sometimes indispensable after failure of other antidepressants.
D000328:Adult; D000368:Aged; D000768:Anesthesia, General / Q000009:adverse effects; D001008:Anxiety Disorders / Q000188:drug therapy*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007490:Iproniazid / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D009526:Nialamide / Q000627:therapeutic use; D010698:Phobic Disorders / Q000188:drug therapy; D012189:Retrospective Studies
D008996:Monoamine Oxidase Inhibitors; D007490:Iproniazid; D009526:Nialamide
Plaidoyer pour les inhibiteurs de la monoamine-oxydase. Etude rétrospective de 350 observations.