Effect of oral 13-cis-retinoic acid on serum lipids.
Serum lipid concentrations were measured in eighteen patients with severe acne before, during and after treatment with 0.8 mg/kg 13-cis-retinoic acid for 3 months. Cholesterol and triglyceride concentrations increased and HDL-cholesterol concentrations fell significantly during therapy. There were significant abnormalities of liver function and small decreases in indices of thyroid function. These changes had reverted to normal by 1 month after treatment. The data suggest that use of the drug in acne is likely to be limited by its toxicity.
D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D005260:Female; D006801:Humans; D015474:Isotretinoin; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D013961:Thyroid Gland / Q000187:drug effects; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014212:Tretinoin; D002784:Cholesterol; D015474:Isotretinoin