Genetic and antigenic requirements for induction of T helper cells for anti-Sendai virus-specific antibody production.
T helper cells for the promotion of Sendai virus-specific antibody production were generated in vitro. They could be stimulated by infectious, UV light-inactivated or fusion-negative Sendai virus, which had to be presented by adherent cells. Induction of T helper cells was virus-specific and required H-2 IA region compatibility between T cells and antigen-presenting cells. Delivery of help to B lymphocytes was neither virus-specific nor H-2-restricted.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000918:Antibody Specificity; D006183:H-2 Antigens / Q000032:analysis* / Q000235:genetics; D006648:Histocompatibility; D009980:Influenza A virus / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects
D000914:Antibodies, Viral; D006183:H-2 Antigens