In utero Epstein-Barr virus (infectious mononucleosis) infection.
A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for his syndrome were negative.
D000015:Abnormalities, Multiple / Q000209:etiology*; D000956:Antigens, Viral / Q000032:analysis*; D001842:Bone and Bones / Q000002:abnormalities; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007244:Infectious Mononucleosis / Q000151:congenital* / Q000276:immunology; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D013577:Syndrome
D000956:Antigens, Viral