Reduction of cell surface fibronectin (LETS protein) correlates with tumorigenicity of hamster fibroblasts transformed by herpes simplex virus type2.
A series of herpes simplex virus type 2 (HSV-2)-transformed hamster cells has been examined using the technique of lactoperoxidase-catalyzed cell surface protein iodination. The amount of cell surface fibronectin (LETS protein) was reduced after HSV-2 transformation, and this reduction correlated with increased tumor-forming ability.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D006224:Cricetinae; D005347:Fibroblasts; D005353:Fibronectins / Q000032:analysis / Q000502:physiology*; D008565:Membrane Proteins / Q000032:analysis; D008647:Mesocricetus; D008970:Molecular Weight; D009374:Neoplasms, Experimental / Q000209:etiology*; D018139:Simplexvirus / Q000502:physiology*
D005353:Fibronectins; D008565:Membrane Proteins