title: [Value of the perifusion of fragments of rat thyroid for the dynamic study of thyroid secretion under TSH and theophylline].
abstract: With the technique of rat thyroid fragment perifusion the kinetics of T4 response to various stimuli can be studied with precision. The response is rapid and brief with theophylline and TSH, which activate membrane adenylcyclase; with the optimal concentrations, however, it is prolonged because only these concentrations can induce the secretion of a more slowly releasable pool of T4.
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D007700:Kinetics; D008722:Methods; D010477:Perfusion; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000378:metabolism
chemical_list: D013972:Thyrotropin; D013806:Theophylline; D013974:Thyroxine
vernacular_title: Intérêt de la périfusion de fragments de thyroïdes de rat pour l'étude dynamique de la sécrétion thyroïdienne sous TSH et théophylline.