title: Biochemical-molecular characteristics of the brain synaptic membrane glutamate receptor.
abstract: The studies described above have provided evidence for the presence of a high affinity, glutamate binding glycoprotein which has some of the pharmacologic characteristics of the recognition site of neuronal glutamate receptors. In addition, evidence was presented for the distinct molecular nature of this glutamate binding protein as compared to that of the kainic acid binding macromolecule in synaptic membranes and also, for the differential characteristics of the glutamate binding sites as compared to the glutamate transport carriers. Finally, information was presented which is suggestive of the presence and functional integrity of glutamate receptor.ion channel complexes in synaptic membrane preparations.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002793:Cholic Acids / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000378:metabolism; D007700:Kinetics; D011485:Protein Binding; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D002793:Cholic Acids; D005971:Glutamates; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D007608:Kainic Acid