Carbohydrates as recognition determinants in phagocytosis and in lectin-mediated killing of target cells.
Carbohydrate-lectin interactions serve as the basis of recognition by phagocytic cells of particles and of various target cells. Such interactions occur in the following systems: between sugars on the surface of the phagocytic cells and lectins on the surface of other cells--the best studied example is the binding of mannose-specific Escherichia coli and related organisms via their surface lectins to oligo-mannose residues on macrophages; between lectins on the surface of phagocytic cells and sugars on particles or other cells--phagocytosis of zymosan and of sialidase-treated erythrocytes, mediated respectively by mannose-specific and galactose-specific lectins on macrophages, belongs to this category; by extracellular lectins that form bridges between sugars on both types of cell--as shown by enhancement of phagocytosis of staphylococci by wheat germ agglutinin, and by lectin-dependent killing of target cells by macrophages. These interactions may play an important role in the activities of phagocytic cells in vivo. They may provide an initial host defense mechanism immediately after microbial infection, operate in tissues where phagocytic activity is poor, and participate in tumor rejection.
D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004926:Escherichia coli / Q000276:immunology; D006023:Glycoproteins / Q000502:physiology; D037102:Lectins; D008264:Macrophages / Q000276:immunology; D008565:Membrane Proteins / Q000502:physiology; D010586:Phagocytes / Q000276:immunology*; D010587:Phagocytosis
D006023:Glycoproteins; D037102:Lectins; D008565:Membrane Proteins