Varicella-zoster virus transformation of hamster embryo cells.
Varicella-zoster virus infection of primary hamster embryo cells resulted in oncogenic transformation. These transformed cells exhibited virus-specific antigens by immunofluorescence and developed surface Fc receptors. They induced aggressive fibrosarcomas when injected into inbred hamsters. The tumour-bearing hamsters develop antibodies to varicella-zoster antigens.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D006224:Cricetinae; D005354:Fibrosarcoma / Q000209:etiology; D014645:Herpesvirus 3, Human / Q000276:immunology / Q000502:physiology*; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D011961:Receptors, Fc; D014184:Transplantation, Homologous
D000914:Antibodies, Viral; D000956:Antigens, Viral; D011961:Receptors, Fc