Thyroid hormone receptor-containing fragment released from chromatin by deoxyribonuclease I and micrococcal nuclease.
Limited deoxyribonuclease I and micrococcal nuclease digestion of hepatic nuclei from euthyroid rats injected with 125I-labeled triiodothyronine ([125I]T3)  releases a discrete [125I]T3-labeled chromatin fragment (5.8S) which is larger than the T3 receptor (3.5S). These results suggest the T3 receptor is associated with a restricted fraction of hepatic chromatin that has a nuclease sensitivity characteristic of transcriptionally active chromatin.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D003851:Deoxyribonucleases / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure; D008836:Micrococcal Nuclease / Q000378:metabolism*; D009707:Nucleosomes / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014284:Triiodothyronine / Q000378:metabolism*
D002843:Chromatin; D009707:Nucleosomes; D011956:Receptors, Cell Surface; D014284:Triiodothyronine; D003851:Deoxyribonucleases; D008836:Micrococcal Nuclease