title: [Karyological characteristics of the transplantable human cell line J-96, susceptible to Coxsackie B3 virus, and of its derived subline J-41, specifically resistant to this virus].
abstract: The paper is concerned with comparative cytogenetic studies of human cell line J-96 and subline J-41 derived from it. Application of G-, R- and C-techniques for differential staining of chromosomes made it possible to determine both numeric and structural changes in chromosomes of the resistant subline as compared to the initial one. The mechanisms contributing to a decrease in the normal chromosome number and to appearance of new marker chromosomes in the resistant subline cells are discussed as well as the possible relation of the found chromosome changes to the loss of cell sensitivity to the Coxsackie B3 virus.
mesh_terms: D002460:Cell Line; D002478:Cells, Cultured / Q000648:ultrastructure*; D002872:Chromosome Deletion; D002904:Chromosomes, Human, 21-22 and Y / Q000648:ultrastructure; D003588:Cytopathogenic Effect, Viral; D029822:Enterovirus B, Human / Q000472:pathogenicity*; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping
chemical_list: D005819:Genetic Markers
vernacular_title: Kariologicheskaia kharakteristika perevivaemoĭ linii kletok cheloveka J-96, chuvstvitel'noĭ k virusu Koksaki B3, i poluchennoĭ iz nee sublinii J-41, spetsificheski rezistentnoĭ étomu virusu.