Erythrocyte enzyme disorders in children.
Erythrocyte metabolic abnormalities should be considered as a possible cause of hemolysis when there is no evidence of an immune-mediated hemolytic anemia, no consumptive red blood cell disorder, no morophologic or laboratory data to suggest a problem of the red cell membrane, and no evidence of a quantitative or qualitative defect in hemoglobin synthesis. Glucose-6-phosphate dehydrogenase deficiency is clearly the most common enzyme deficiency causing clinical problems.
D015720:5'-Nucleotidase; D000243:Adenosine Deaminase / Q000172:deficiency; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000745:Anemia, Hemolytic, Congenital / Q000201:enzymology / Q000503:physiopathology; D002648:Child; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D004913:Erythrocytes, Abnormal / Q000201:enzymology*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000503:physiopathology; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000172:deficiency; D005980:Glutathione Reductase / Q000172:deficiency; D005981:Glutathione Synthase / Q000172:deficiency; D006019:Glycolysis; D006461:Hemolysis; D006600:Hexosephosphates / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008661:Metabolism, Inborn Errors / Q000097:blood*; D009708:Nucleotidases / Q000172:deficiency; D011742:Pyrimidine Nucleotides / Q000172:deficiency; D011770:Pyruvate Kinase / Q000172:deficiency
D006600:Hexosephosphates; D011742:Pyrimidine Nucleotides; D000255:Adenosine Triphosphate; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D011770:Pyruvate Kinase; D009708:Nucleotidases; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D005981:Glutathione Synthase; D005978:Glutathione