Effect of iodide on estrogen-induced uterine peroxidase.
Iodide administered in the drinking water for 5-7 days increased the activity of estradiol-induced uterine peroxidase in the immature rat. This effect was specific for iodide and could not be mimickead by chloride, bromide, thiocyanate, perchlorate or iodate. Sodium iodide also increased peroxidase activity in the parotid gland but had no effect on glucose-6-phosphate dehydrogenase in the uterus, thyroid or parotid even though estradiol produced a 2-fold increase in the activity of this enzyme in the uterus. 125I was taken up more readily by the uterus than by muscle but this process was not influenced by prior treatment of the animals with estrogen. The in vitro effect of sulfhydryl reagents on uterine peroxidase was also investigated and proposals made for possible mechanisms of action of iodide on this enzyme in the intact animal.
D000818:Animals; D004790:Enzyme Induction; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007454:Iodides / Q000494:pharmacology*; D007527:Isoenzymes / Q000096:biosynthesis / Q000378:metabolism*; D009195:Peroxidase; D010544:Peroxidases / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D012974:Sodium Iodide / Q000494:pharmacology*; D013439:Sulfhydryl Reagents / Q000494:pharmacology; D014599:Uterus / Q000201:enzymology*
D007454:Iodides; D007527:Isoenzymes; D013439:Sulfhydryl Reagents; D004958:Estradiol; D005954:Glucosephosphate Dehydrogenase; D010544:Peroxidases; D009195:Peroxidase; D012974:Sodium Iodide