The influence of antibrain antibodies on the level of enzyme activity and ultrastructure of brain.
The paper is concerned with the effect antibrain antiserum may exert on the activity of succinic dehydrogenase, glutamic dehydrogenase, cytochrome oxidase, and peroxidase. By means of quantitative cytochemistry and electron microscopy it was demonstrated that activity of succinic dehydrogenase activity or cytochrome oxidase increased in the cortex and hypothalamus following the injection of anti-cortex or anti-hypothalamic serum. There were no changes of glutamic dehydrogenase and peroxidase found. Nonspecific alterations of neuronal fine structures were observed in both the cortex and the hypothalamus of rabbits treated with antiserum.
D000818:Animals; D001323:Autoantibodies / Q000502:physiology*; D002540:Cerebral Cortex / Q000201:enzymology / Q000276:immunology* / Q000648:ultrastructure; D003576:Electron Transport Complex IV / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D007031:Hypothalamus / Q000276:immunology*; D007032:Hypothalamus, Anterior / Q000201:enzymology / Q000276:immunology* / Q000648:ultrastructure; D010088:Oxidoreductases / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism
D001323:Autoantibodies; D010088:Oxidoreductases; D010544:Peroxidases; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase; D003576:Electron Transport Complex IV