The heart and diabetes. Vascular and metabolic aspects.
The metabolic changes in the heart--increased glycogen, triglycerides, and cyclic AMP, and decreased ATP and creatine phosphate--indicate that diabetes is a generalized disorder of cellular metabolism. The summarized observations provide additional biochemical reasons for early detection and treatment of patients with diabetes mellitus. Cognizance of three metabolic events are relevant to the treatment of the diabetic patient during acute cardiac events such as myocardial infarction.
D000255:Adenosine Triphosphate / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications*; D000242:Cyclic AMP / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D006003:Glycogen; D000242:Cyclic AMP