title: DNA N-glycosylases and UV repair.
abstract: Repair of some DNA photoproducts can be mediated by glycosylic bond hydrolysis. Thus, Escherichia coli endonuclease III releases 5,6-hydrated thymines as free bases, while T4 UV endonuclease releases one of two glycosylic bonds holding pyrimidine dimers in DNA. In contrast, uninfected E. coli apparently does not excise pyrimidine dimers via a DNA glycosylase.
mesh_terms: D004247:DNA / Q000378:metabolism; D045647:DNA Glycosylases; D004260:DNA Repair; D043224:Deoxyribonuclease (Pyrimidine Dimer); D003851:Deoxyribonucleases / Q000378:metabolism; D004706:Endodeoxyribonucleases; D004720:Endonucleases / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000528:radiation effects; D029968:Escherichia coli Proteins; D006026:Glycoside Hydrolases / Q000378:metabolism*; D011740:Pyrimidine Dimers / Q000378:metabolism; D013379:Substrate Specificity; D013604:T-Phages / Q000201:enzymology; D014466:Ultraviolet Rays
chemical_list: D029968:Escherichia coli Proteins; D011740:Pyrimidine Dimers; D004247:DNA; D003851:Deoxyribonucleases; D004706:Endodeoxyribonucleases; D004720:Endonucleases; D043224:Deoxyribonuclease (Pyrimidine Dimer); C106403:NTH protein, E coli; D006026:Glycoside Hydrolases; D045647:DNA Glycosylases