title: [Aujeszky's disease: serological responsiveness after vaccination of 6-10-week-old piglets with maternal antibody (author's transl)].
abstract: Trials were made to study the extent to which 6-10-week-old piglets with and without virus-neutralizing (VN) antibodies are capable of a serological response to vaccination. The piglets were inoculated with three different vaccines: two live vaccines (Aescovac Aujeszky and MK25 vaccine) and an inactivated vaccine (Geskyvac). The titre of virus-neutralizing antibody in the blood was determined for each vaccine in approximately 200 piglets at the time of inoculation as well as within four and twelve weeks after inoculation. The maternal antibodies present at the time of inoculation were found to have an inhibitory action on the serological response following inoculation. Of those piglets in which a maternal VN titre was observed using the above technique, only 9 per cent showed an increase in titre after inoculation. This proportion was 74 per cent in the serologically negative piglets. Marked variations in serological response to the different vaccines were observed. the most positive response was that induced by Aescovac. There was an obvious relationship between the VN titre following inoculation and immunity against intracerebral challenge with 2,000 TCID50 of Aujeszky disease virus. Animals showing titres of 1:4 or over were immune to this challenge.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D011557:Pseudorabies / Q000517:prevention & control*; D013552:Swine / Q000276:immunology; D013553:Swine Diseases / Q000517:prevention & control*; D014765:Viral Vaccines / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines
vernacular_title: Ziekte van Aujeszky: entbaarheid van biggen met maternale antistoffen op een leeftijd van 6-10 weken.