Catabolite repression of different inducible enzymes in Escherichia coli and the effect of cAMP.
Simultaneous induction of two enzymes sensitive to catabolite repression does not lead to an additive decrease of the specific activity of the two. Exogenously added cAMP increases the specific activity of catabolically repressed enzymes, irrespective of whether the enzyme is induced separately or simultaneously with another enzyme. In the presence of 12 different substrates metabolized by inducible enzymes glucose does not bring about catabolite repression. Synthesis of cAMP is identical with that occurring under conditions when glucose brings about catabolite repression.
D000242:Cyclic AMP / Q000494:pharmacology*; D004790:Enzyme Induction; D004794:Enzyme Repression / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D005942:Gluconates / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D012695:L-Serine Dehydratase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D014368:Tryptophanase / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
D005942:Gluconates; D000242:Cyclic AMP; D008291:Malate Dehydrogenase; D001616:beta-Galactosidase; D014368:Tryptophanase; D012695:L-Serine Dehydratase; D005947:Glucose; D005990:Glycerol; C030691:gluconic acid