Characterization of the inflammatory cells in progressing tumor-like alveolar hydatid cyst. 2. Cell surface receptors, endocytosed immune complexes and lysosomal enzyme content.
Alveolar hydatid cysts (LCM) grow progressively and contribute significantly to the morbidity of hydatid-hosts. To examine whether modifications in immune effector parameters correlate with the pattern of LCM growth, in vivo experiments were carried out in C57BL/6J mice infected intraperitoneally with LCM. Immigrant peritoneal and intra-LCM leukocytes were tested for the loss of cell surface receptors, membrane-bound and internalized immune complexes (ICs) and lysosomal enzyme contents during the restrictive and progressive growth phases of the LCM. The proportion of Fc and C3b receptor-bearing intra-LCM leukocytes decreased 2-fold and 31 to 72% of the leukocytes contained ICs during the progressive phase of the LCM. Acid phosphatase and beta-glucuronidase activities of macrophages declined sharply during the restrictive phase but they gradually increased as the infection progressed. IC-mediated dysfunction of effector leukocytes and modulation of antibody dependent cell cystolysis mechanism are discussed in murine hydatidosis.
D000135:Acid Phosphatase / Q000032:analysis*; D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D004445:Echinococcosis, Pulmonary / Q000276:immunology*; D004705:Endocytosis; D005455:Fluorescent Antibody Technique; D005966:Glucuronidase / Q000032:analysis*; D007694:Killer Cells, Natural / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011951:Receptors, Complement / Q000276:immunology*; D017463:Receptors, Complement 3b; D011961:Receptors, Fc / Q000276:immunology*; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D011961:Receptors, Fc; D000135:Acid Phosphatase; D005966:Glucuronidase