Depression of cyclic AMP and cyclic GMP in the cerebrospinal fluid of rats after acute administration of ethanol.
The effect of single oral doses of ethanol on the levels of cyclic AMP and cyclic GMP in the cerebrospinal fluid was studied in rats. Ethanol markedly decreased the levels of both cyclic nucleotides for at least 24 h. The decrease of cyclic nucleotides after medium and high doses (1.65 and 4.59 g/kg) was slower in onset but more pronounced than the decrease after a low dose (0.55 g/kg)  of ethanol.
D000818:Animals; D000242:Cyclic AMP / Q000134:cerebrospinal fluid*; D006152:Cyclic GMP / Q000134:cerebrospinal fluid*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats
D000431:Ethanol; D000242:Cyclic AMP; D006152:Cyclic GMP