title: [Genome instability].
abstract: The paper deals with the various manifestations and the role of genome changes, mainly in eukaryotes. I. Hereditary changes: 1) multiplication of genes in animals; 2) multiplication of genes in prokaryotes; 3) microsymbionts, mobile elements and supermutability; 4) extrachromosomal element delta in Drosophila; 5) hybrid dysgenesis in Drosophila; 6) mobile and unstable genes in drosophila; 7) controlling elements in planrs. II. Genome changes as a regulatory factor of genetic activity: 1) immunoglobulin genes; 2) mating types in yeast; 3) the inversion mechanism of switching gene activity in prokaryotes; 4) ribosomal and histone genes; 5) changes of DNA fractions in ontogenesis; 6) regulation of genome changes.
mesh_terms: D000818:Animals; D004247:DNA / Q000032:analysis; D004251:DNA Transposable Elements; D004330:Drosophila / Q000235:genetics; D005786:Gene Expression Regulation; D005796:Genes; D014644:Genetic Variation; D005838:Genotype; D006657:Histones / Q000235:genetics; D006824:Hybridization, Genetic; D007136:Immunoglobulins / Q000235:genetics; D051379:Mice; D009154:Mutation; D009858:Oncogenic Viruses / Q000235:genetics; D010944:Plants / Q000235:genetics; D010957:Plasmids; D012335:RNA, Ribosomal / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D015003:Yeasts / Q000235:genetics
chemical_list: D004251:DNA Transposable Elements; D006657:Histones; D007136:Immunoglobulins; D012335:RNA, Ribosomal; D004247:DNA
vernacular_title: Nepostoianstvo genoma.