Tolerance and immunity in mice infected with herpes simplex virus: studies on the mechanism of tolerance to delayed-type hypersensitivity.
Tolerance to delayed-type hypersensitivity is produced in mice following an intravenous injection of herpes simplex virus. This form of tolerance is produced early on, following simultaneous injections of virus subcutaneously and intravenously, and is long lasting (greater than 100 days). The early tolerance mechanism is resistant to high doses of cyclophosphamide and is not transferable by serum or spleen cells taken after 7 days. However, spleen cells taken at 14 days onwards inhibit the induction of delayed hypersensitivity when transferred to normal syngeneic recipients. These cells are T lymphocytes and are specific for the herpes type used in the induction.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D006968:Hypersensitivity, Delayed; D007106:Immune Sera / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000637:transplantation; D013997:Time Factors; D014185:Transplantation, Isogeneic
D000956:Antigens, Viral; D007106:Immune Sera; D003520:Cyclophosphamide