Glucose tolerance and blood lipids in bran-fed patients with impaired glucose tolerance.
Thirty-eight patients (13 men and 25 women) with impaired glucose tolerance, aged 33--70 yr, underwent a dietary program adding 20 g of raw bran to their usual diet without changing their dietary habits. After 1 mo of treatment, the areas under the curves for glucose and insulin were reduced from 26,214 +/- 5618 to 24,529 +/- 5207 g/min (P < 0.001) and from 15,893 +/- 9714 to 12,440 +/- 7377 mU/min (P < 0.001), respectively, cholesterol was reduced from 234 +/- 40 to 212 +/- 29 mg/dl (P < 0.001), and triglycerides were reduced from 108 +/- 56 to 97 +/- 50 mg/dl (P < 0.05). Body weight (initially 128.44% relative body weight) decrease 0.8% (P < 0.02). After the first month, 14 subjects were studied for a further 2 mo. Six patients continued bran feeding, and eight, who stopped bran, were used as controls. Patients who took bran maintained metabolic improvement over the 3-mo treatment period, while those who stopped bran did not.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002482:Cellulose / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D004043:Dietary Fiber / Q000627:therapeutic use*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood* / Q000178:diet therapy; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D004043:Dietary Fiber; D007328:Insulin; D014280:Triglycerides; D002482:Cellulose; D002784:Cholesterol