Cell-mediated immunity in herpes simplex virus-infected mice: induction, characterization and antiviral effects of delayed type hypersensitivity.
Delayed type hypersensitivity (DTH) was induced ihe reaction was observed 4 to 5 days p.i. and could still be induced up to 18 months later. In contrast, the adoptive transfer of DTH using draining lymph node cells was only possible during the period 6 to 10 days p.i. The cells taken at these times also contained mediators of antiviral immunity, as determined by a marked reduction of virus titres in the ears of infected animals 1 to 3 days after transfer. Draining lymph node cells taken at later times contained mediators of virus immunity, but titres were not reduced until day 5 after the transfer. The cell type involved in both the DTH and antiviral activity was a T lymphocyte, although the particular T cell subsets involved have yet to be determined.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D005260:Female; D006561:Herpes Simplex / Q000276:immunology* / Q000382:microbiology; D006968:Hypersensitivity, Delayed; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000637:transplantation; D051379:Mice; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000254:growth & development / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum