Effects of caffeine withdrawal on isoproterenol-stimulated cyclic adenosine monophosphate.
The effect of short-term caffeine withdrawal on lymphocyte beta-adrenoceptor sensitivity was studied in seven men who had been drinking coffee daily for at least 3 mo before the study. The ratio of cyclic adenosine monophosphate production after in vitro incubation with isoproterenol and a blank was used to assess receptor sensitivity. There was a reduction in sensitivity to isoproterenol but not to prostaglandin E1 3 days after caffeine withdrawal. The mechanism of this effect is not clear, but may represent a biochemical correlate of caffeine-withdrawal syndrome.
D000313:Adrenal Medulla / Q000187:drug effects; D000328:Adult; D000527:Alprostadil; D002110:Caffeine / Q000009:adverse effects*; D000242:Cyclic AMP / Q000097:blood*; D004361:Drug Tolerance; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000097:blood*
D011458:Prostaglandins E; D011941:Receptors, Adrenergic; D002110:Caffeine; D000242:Cyclic AMP; D000527:Alprostadil; D007545:Isoproterenol