title: [Mechanism of the activating action of noradrenaline on rat cerebral cortex Na, K-ATPase].
abstract: Effect of noradrenaline on kinetics of Na, K-ATPase activation in rat brain cortex was studied using ATP as a substrate and Na+ or K+ ions as cofactors. Noradrenaline (5 x 10(-5) M) increased the activating effect of ATP and Mg2+ as well as that of Na+ and K+. In presence of ATP and Mg2+ the hormone activated ATPase by the mixed type, and in response to Na+, K+ addition--by the non-competitive type. Noradrenaline appears to cause the conformational alterations in Na, K-ATPase molecule, which change the kinetics of the enzyme activation by ATP and the ions.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013379:Substrate Specificity / Q000187:drug effects
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine
vernacular_title: Issledovanie mekahnizma aktiviruiushchego deĭstviia noradrenalina na Na, K-ATF-azu kory mozga krys.