Transfusion induced acquired immunodeficiency syndrome (AIDS) with Kaposi's sarcoma in a patient with congenital factor V deficiency.
The first instance ever reported of transfusion induced AIDS with Kaposi's sarcoma in a non-homosexual patient is presented in detail. Our experience in this case supports the theory that a transfusion induced viral agent or agents which may affect the immunoregulatory mechanism could be the underlying cause. The rarity of patients such as ours suggests that other, so far undescribed, factors must be playing an essential role in the development of this rare form of cancer in high risk groups represented by patients with AIDS. Further studies are needed to ascertain the mechanisms whereby the different expressions of this syndrome are manifested in such patients.
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology* / Q000635:transmission; D000328:Adult; D005166:Factor V Deficiency / Q000150:complications* / Q000151:congenital; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D012514:Sarcoma, Kaposi / Q000150:complications*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D065227:Transfusion Reaction
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II