Changes of ejaculation due to suppression of noradrenaline biosynthesis by diethyldithiocarbamate.
The effects of diethyldithiocarbamate on manually induced erection and ejaculation and on monoamines in the brain and male reproductive organs were investigated in male mongrel dogs. From the results obtained in this study it was concluded that diethyldithiocarbamate suppresses ejaculation, although penile erection is maintained, and that the suppression is not mediated by the central nervous system but by the changes of the monoamine levels in the organs relating to sperm transport.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004050:Ditiocarb / Q000494:pharmacology*; D004285:Dogs; D004298:Dopamine / Q000378:metabolism; D004542:Ejaculation / Q000187:drug effects*; D004822:Epididymis / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis* / Q000378:metabolism; D010413:Penis / Q000502:physiology; D012701:Serotonin / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D013859:Thiocarbamates / Q000494:pharmacology*
D013859:Thiocarbamates; D012701:Serotonin; D004050:Ditiocarb; D004298:Dopamine; D009638:Norepinephrine