Anticonvulsant effects of careulein and cholecystokinin octapeptide, compared with those of diazepam.
Caerulein and the C-terminal octapeptide of cholecystokinin (CCK-8), after subcutaneous administration to mice, both delayed the onset and retarded the development of toxic effects of convulsants such as strychnine, pentetrazol, bicuculline, and picrotoxin. They also increased the seizure threshold doses of intravenously infused pentetrazol and picrotoxin. In this regard, both peptides were at least equipotent with diazepam.
D000818:Animals; D000927:Anticonvulsants; D001640:Bicuculline / Q000494:pharmacology; D002108:Ceruletide / Q000494:pharmacology*; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced; D012844:Sincalide; D013331:Strychnine / Q000494:pharmacology; D013997:Time Factors
D000927:Anticonvulsants; D002108:Ceruletide; D002766:Cholecystokinin; D013331:Strychnine; D012844:Sincalide; D003975:Diazepam; D010433:Pentylenetetrazole; D001640:Bicuculline