title: Hepatic and splenic scintigraphy in idiopathic systemic amyloidosis.
abstract: Technetium-99m sulfur colloid (SC) and Technetium-99m pyrophosphate (PYP) scintigrams in a patient with idiopathic systemic amyloidosis were abnormal. Hepatic SC distribution was nonhomogeneous. Spleen showed reduced SC uptake and a large focal defect at its upper pole. Splenic localization of PYP was seen on a bone scan. On histologic examination the abnormal scintigraphic sites showed heavy amyloid deposition. Splenic localization of skeletal radiotracer due to amyloidosis has not been previously reported.
mesh_terms: D000686:Amyloidosis / Q000000981:diagnostic imaging*; D003102:Colloids; D011756:Diphosphates; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging*; D013455:Sulfur; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D003102:Colloids; D011756:Diphosphates; D013671:Technetium Tc 99m Sulfur Colloid; D016698:Technetium Tc 99m Pyrophosphate; D013455:Sulfur; D013667:Technetium