[Mixed cryoglobulinaemia and benign monoclonal gammopathy in Sjogren's syndrome (author's transl)].
The authors report a case of Sjögren's syndrome associated with Raynaud phenomenon and mixed IgM-IgG cryoglobulinaemia. Three years after the onset of this association:--Immunoelectrophoresis of the serum showed a monoclonal IgM (lambda) protein, --the level of the mixed IgM-IgG cryoglobulinaemia had increased from 28 mcg/ml up to 12 mg/ml and its IgM component was monoclonal (lambda) with anti-IgG activity. Search for amyloïdosis and for a malignant lymphoma was negative. Such an association of a benign monoclonal gammopathy, mixed cryoglobulinaemia and Sjögren's Syndrome has only exceptionally been reported in the literature.
D000368:Aged; D003450:Cryoglobulins; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010265:Paraproteinemias / Q000150:complications*; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications*
D003450:Cryoglobulins; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Syndrome de Gougerot-Sjögren, gammapathie monoclonale bénigne et cryoglobulinémie mixte.