title: An age-related coagulation disorder associated with experimental infection with infectious bursal disease virus.
abstract: Specific-pathogen-free White Leghorn chickens were inoculated with a field strain of infectious bursal disease virus. One group (A) was inoculated at 17 days after the chicks were hatched, and the other groups (C and E) were inoculated at posthatch day 42. Blood samples were obtained for determination of clotting times (whole blood recalcification, prothrombin, and activated partial thromboplastin times), virus-neutralizing antibody, and total hemolytic complement. There were significant increases in clotting times for groups C and E at 3 and 5 days after they were inoculated. There were no significant increases in clotting times at 3 days after inoculation in the group A chickens (inoculated at 17 days after hatching). There were no significant decreases in total complement activity in any of these chickens (groups A, C, and E). This study indicates that the mortality and clinical symptoms observed in chickens experimentally infected with infectious bursal disease virus may be associated with a clotting abnormality because it was noted only in chickens that developed severe clinical disease (inoculated at 42 days after hatching) and was not noted in chickens that remained clinically normal (inoculated at 17 days).
mesh_terms: D000367:Age Factors; D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D003165:Complement System Proteins / Q000032:analysis; D007243:Infectious bursal disease virus; D011201:Poultry Diseases / Q000097:blood* / Q000473:pathology; D012088:Reoviridae Infections / Q000097:blood / Q000473:pathology / Q000662:veterinary*
chemical_list: D003165:Complement System Proteins