Improvement of gliding function of flexor tendons by topically applied enriched collagen solution.
The long flexor tendons of the second, third and fourth toes of 94 chickens were cut and sutured. After operation the birds were divided into three groups. To reduce peritendinous adhesions, an aqueous solution of beta-aminopropionitrile (BAPN) was added to a solution of enriched native collagen (ECS) and applied to the cut tendons of one group; untreated controls and controls treated with collagen solution alone comprised the other groups. Chickens from each group were killed one, two, three, four and five weeks after operation. The results were evaluated both biomechanically and biochemically. It was found that the collagen solution alone had the same effect as the treatment with BAPN. It is suggested that the exogenous collagen present at the site of injury binds the collagenase inhibitor released by tendon cells, thus providing enough active collagenase to control the formation of fibrous adhesions. The inefficiency of BAPN in these experiments might have been due to either inadequate dosage or wrong timing, or both.
D000629:Aminopropionitrile / Q000627:therapeutic use*; D000818:Animals; D001696:Biomechanical Phenomena; D002645:Chickens; D003094:Collagen / Q000627:therapeutic use*; D004247:DNA / Q000032:analysis; D005528:Foot; D006909:Hydroxyproline / Q000032:analysis; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors; D011506:Proteins / Q000032:analysis; D013708:Tendon Injuries / Q000503:physiopathology; D013710:Tendons / Q000032:analysis / Q000187:drug effects*; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects*
D011506:Proteins; D000629:Aminopropionitrile; D003094:Collagen; D004247:DNA; D003012:Microbial Collagenase; D006909:Hydroxyproline