Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic adenosine monophosphate accumulation in human platelets.
The effect of acute methadone withdrawal was studied on PGE1-sensitive platelet adenylate cyclase of 8 former heroin addicts who had been stabilized with methadone. During acute methadone withdrawal there was a significant increase in PGE1-sensitive platelet adenylate cyclase activity, which correlated with the severity of withdrawal symptoms. This suggests that PGE1-sensitive adenylate cyclase and cyclic adenosine monophosphate (cyclic AMP) are involved in the human addictive process.
D000262:Adenylyl Cyclases / Q000097:blood; D001792:Blood Platelets / Q000201:enzymology*; D002460:Cell Line; D000242:Cyclic AMP / Q000097:blood*; D006801:Humans; D008691:Methadone; D009021:Morphine Dependence / Q000201:enzymology; D009638:Norepinephrine / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D013997:Time Factors
D011458:Prostaglandins E; D011942:Receptors, Adrenergic, alpha; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D008691:Methadone; D009638:Norepinephrine