Phase changes induced by ketamine in the vertical vestibulo-ocular reflex in the rabbit.
The effect of ketamine has been tested on the phase of the vertical vestibulo-ocular reflex of rabbits sinusoidally oscillated at various frequencies. A significant phase lag, predominantly affecting the macular component of the reflex, was observed. This action resembles that induced by Nembutal in the same preparation. A specific action of ketamine on synaptic transmission is suggested. Erroneous phase relationship between natural stimuli responses can be obtained in experiments employing ketamine.
D000818:Animals; D004576:Electromyography; D005133:Eye Movements / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D014722:Vestibule, Labyrinth / Q000187:drug effects
D007649:Ketamine