[Interrelations of lysosomal enzymes of leukocytes in patients with cicatricial stenosis of the larynx].
Activities of acid and alkaline phosphatases, cathepsin B, leucine aminopeptidase, N-acetyl-beta-D-hexosaminidases, beta-D-galactosidase and beta-D-glucuronidase were studied in leukocytes of two groups of patients with normal and pathological healing of wounds after surgical treatment of scar stenosis of larynx. Analysis of the enzymatic activity, calculated by means of Student's test using the data of a single estimation of the activity in leukocytes before surgical treatment, did not exhibit any distinct differences in these two groups of patients. The study of interrelationship between the activities of individual enzymes by means of principles of regression analysis enabled to show that the enzymes studied were in the positive regressive relation. Pattern of enzymatic activity in leukocytes of patients with pathological wound healing was distinctly different from that of patients with normal healing in the shape of regression and, especially, in relaxation of the interrelations between phosphatases and other enzymes. The principle of regression enabled to evaluate the prognosis of postoperative development of wound healing using the preliminary estimation of enzymatic activity in leukocytes of patients with scar stenosis of larynx.
D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D002402:Cathepsin D / Q000097:blood; D002921:Cicatrix / Q000097:blood* / Q000473:pathology; D003251:Constriction, Pathologic; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D007818:Laryngeal Diseases / Q000097:blood* / Q000473:pathology; D007962:Leukocytes / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D008875:Middle Aged; D012044:Regression Analysis; D001616:beta-Galactosidase / Q000097:blood; D001619:beta-N-Acetylhexosaminidases
D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D006596:Hexosaminidases; D001616:beta-Galactosidase; D001619:beta-N-Acetylhexosaminidases; D002402:Cathepsin D
Vzaimosviazi lizosomal'nykh fermentov leĭkotsitov u bol'nykh s rubtsovym stenozom gortani.