[Interest of ganglioside analysis in the neuroblastoma (author's transl)].
As suggested by Hakomori, one of the mechanisms to explain the abnormal proliferation of tumor cells by loss of contact inhibition could be a modification of membrane gangliosides. We report here a case of neuroblastoma with opsomyoclonia in which the ganglioside profile is abnormal, with a high level of GP3 and GM2, and of other gangliosides which are not present in normal child and adult brains.
D001932:Brain Neoplasms / Q000097:blood / Q000378:metabolism*; D005260:Female; D005732:Gangliosides / Q000032:analysis* / Q000097:blood; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000097:blood / Q000378:metabolism*
D005732:Gangliosides
Intérêt de l'analyse des gangliosides dans le neuroblastome.