A comparison of oestrogen-progestogen with clonidine in the climacteric syndrome.
Twenty-three cases of the climacteric syndrome were analysed in a double-blind study comparing the effect of conjugated equine oestrogen (Premarin) and medrogestone (Colpro) with clonidine (Dixarit) on various clinical parameters. The treatment lasted 20 weeks. Statistical analysis of the results indictaed that opposed oestrogen therapy was effective in reducing hot flushes (P < 0,05) whereas clonidine was not. The other variables tested did not attain statistical significance.
D002979:Climacteric / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008524:Medrogestone / Q000627:therapeutic use*; D008875:Middle Aged; D011245:Pregnadienes / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation
D004966:Estrogens, Conjugated (USP); D011245:Pregnadienes; D008524:Medrogestone; D003000:Clonidine