H-2-controlled polymorphism of the gamma chain of Slp (sex-limited protein).
A genetic polymorphism detected by the O'Farrell two-dimensional technique (isoelectric focusing and SDS-PAGE) of the murine sex-limited protein (Slp) is described and shown to map to the H-2 complex. The Slp charge variation was found to be in the gamma chains. Inbred strains carrying the H-2w7 and H-2wr7 haplotypes, which are derived from a wild mouse, had Slp-gamma chains with pI = 6.55 (Slp-1b). All other inbred strains, bearing H-2j,H-2s,H-2p,H-2d,H-2u, as well as three additional Slp-constitutive wild females captured in Chile, had Slp-gamma chain with pI = 6.71 (Slp-1a).
D000818:Animals; D000835:Animals, Wild; D001798:Blood Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D003181:Complement C4; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D007125:Immunogenetics; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011110:Polymorphism, Genetic
D001798:Blood Proteins; C018386:C4a protein, mouse; D003181:Complement C4; D006183:H-2 Antigens