title: Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex.
abstract: Transverse slices of the rat hippocampus were used to examine the ability of phosphonate analogues of acidic amino acids to inhibit perforant path synaptic transmission. Micromolar concentrations of L-2-amino-4-phosphonobutyric acid (APB), an analogue of L-glutamic acid, inhibited transmission from the lateral entorhinal cortex. Two other less-sensitive components were detected in projections from the medial entorhinal cortex. The component from the lateral entorhinal cortex showed high stereospecificity for the L-isomer of APB and was relatively insensitive to phosphonate homologues of shorter and longer chain length.
mesh_terms: D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D008032:Limbic System / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects; D009434:Neural Pathways / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D000613:Aminobutyrates; D009943:Organophosphorus Compounds; C012729:2-amino-4-phosphonobutyric acid