Comparison of cefotaxime and moxalactam pharmacokinetics and tissue levels.
The pharmacokinetics of cefotaxime and moxalactam were compared in six healthy male volunteers aftr the administration of 1-g doses intravenously. Penetration of the compounds into tissue fluid was studied in cantharides-induced blisters. Both serum and tissue fluid levels of moxalactam were higher than those of cefotaxime. The elimination half-life of cefotaxime was 1.2 h, and that of moxalactam was 2.85 h. On the average, 50.5% of cefotaxime and 87.5% of moxalactam were recovered in the urine in 24 h.
D000328:Adult; D001768:Blister / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D002439:Cefotaxime; D002511:Cephalosporins / Q000378:metabolism*; D002513:Cephamycins / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008297:Male; D009070:Moxalactam
D002511:Cephalosporins; D002513:Cephamycins; D002439:Cefotaxime; D009070:Moxalactam