Selenomethionine liver scanning in the diagnosis of hepatoma.
Liver subtraction scans using 99Tcm sulphur coloid and 75Se-selenomethionine were carried out in 58 patients with suspected hepatoma. Of the 18 patients with hepatoma proven by histology, 16 showed selective concentration of selenomethionine in the tumour, giving a true positive rate of 89%. Of the 40 patients who did not have hepatoma, 32 scans showed no evidence of selective concentration of selenomethionine, giving a true negative rate of 80%. The false positive rate was 8% in non-cirrhotic patients with focal disease, but 55% in patients with cirrhosis. It is concluded that combined scanning with this technique is useful in non-cirrhotic patients in distinguishing hepatoma from other causes of focal disease, but that the technique is not useful and frequently misleading in patients with cirrhosis.
D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005189:False Positive Reactions; D006801:Humans; D008107:Liver Diseases / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012643:Selenium; D012645:Selenomethionine; D013455:Sulfur; D013667:Technetium; D013671:Technetium Tc 99m Sulfur Colloid
D011868:Radioisotopes; D013671:Technetium Tc 99m Sulfur Colloid; D013455:Sulfur; D013667:Technetium; D012645:Selenomethionine; D012643:Selenium