Effect of NaF on rat tissue cAMP levels in vivo.
This investigation demonstrates that intraperitoneal injections of NaF (15 mg F/kg) results in hyperglycemia, inhibition of glycolysis, and an increase in tissue cAMP concentrations. Sodium fluoride significantly increases the cAMP concentration in liver, submaxillary gland, lung, heart, and kidney within 60 minutes following the injection.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D005459:Fluorides / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology*
D012969:Sodium Fluoride; D000242:Cyclic AMP; D005947:Glucose; D005459:Fluorides