Properties of a macrophage cell line transformed by simian virus 40. Morphological changes related to cell functions.
A mouse macrophage clone (line nH-1) transformed by simian virus 40 (SV40) was examined by electron microscopy. In the growing phase of the cultures, NH-1 cells were non-phagocytic and SV40 T antigen-positive, and contained a large number of filament sheaths within their pseudopodia. In the late stationary phase, they became phagocytic, SV40 T antigen-negative and contained a filamentous network within their psudopodia. In addition, NH-1 cells in the late stationary phase were very similar to normal macrophages in other morphological properties.
D002460:Cell Line; D002472:Cell Transformation, Viral; D008264:Macrophages / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D013539:Simian virus 40