Homocysteine induced convulsions: enhancement by vitamin B6 and inhibition by hydrazine.
The effects of pyridoxal phosphate, pyridoxine and hydrazine were studied on homocysteine-induced seizures in mice. Both of the B6 vitamers significantly decreased the latency and increased the severity, lethality and duration of seizures induced by homocysteine. The B6 inhibitor hydrazine sulfate, which is normally a convulsant, prevented the tonic component of the convulsions and increased the latency to the clonic component. This experiment indicates that a vitamin B6 dependent step is critically involved in the metabolic changes which precede homocysteine seizures.
D000818:Animals; D005260:Female; D006710:Homocysteine / Q000494:pharmacology*; D006834:Hydrazines / Q000494:pharmacology*; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects*; D011736:Pyridoxine / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced*; D009435:Synaptic Transmission / Q000187:drug effects
D006834:Hydrazines; D006710:Homocysteine; C029424:hydrazine; D011736:Pyridoxine