The effect of mouse strain on the pathogenesis of the encephalitis and demyelination induced by avirulent Semliki Forest virus infections.
Mice from the following strains--Simpson, SWR/J, TO, CBA/Ca, CW (outbred), LAC/G (outbred), SJL/J and Swiss A2G (outbred)--were infected i.p. with avirulent Semliki Forest virus. Clinical signs of disease were noted, histopathological changes assessed and the blood and brain virus infectivities and serum immunoglobulin levels were measured. Only the CW, TO and Swiss/A2G animals showed convincing evidence of demyelination at the light microscopy level but all strains developed encephalitis and microcystic (spongiform) lesions.
D000818:Animals; D003711:Demyelinating Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D004660:Encephalitis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D051379:Mice / Q000382:microbiology*; D008815:Mice, Inbred Strains / Q000382:microbiology; D012672:Semliki forest virus / Q000472:pathogenicity*; D014036:Togaviridae Infections / Q000276:immunology
D007074:Immunoglobulin G