title: Alpha globin gene number: population and restriction endonuclease studies.
abstract: Restriction endonuclease analysis was used to test a proposed genetic model using alpha-globin gene number to account for the observed distributions of the proportions of hemoglobin (Hb) S in sickle cell trait. In a subsample of specimens collected during a population survey in India, these studies confirmed that the postulated genotype was present in 22 of the 23 individuals examined. In the study population, the number of alpha-globin genes explains about 90% of the variance in the proportion of HbS in sickle cell trait (r2 = 0.895, p less than 10(-10)).
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood*; D004262:DNA Restriction Enzymes / Q000378:metabolism*; D005796:Genes; D005838:Genotype; D006451:Hemoglobin, Sickle / Q000032:analysis*; D006801:Humans; D007194:India; D012805:Sickle Cell Trait / Q000097:blood*
chemical_list: D006451:Hemoglobin, Sickle; D004262:DNA Restriction Enzymes