title: Islet cell adenomatosis: a report of two cases and review of the literature.
abstract: Two cases of nesidioblastosis in infants with severe neonatal hypoglycemia were studied by immunocytochemical staining and electron microscopic examination of the resected pancreata. There was a diffuse proliferation of insulin-, glucagon-, and somatostatin-producing cells in both cases. A 0.6-cm adenoma present in one cases consisted of insulin-, glucagon-, and somatostatin-producing cells in close proximity to ductal cells. Pancreatic polypeptides-producing cells were also identified by electron microscopy. These findings indicate that some adenomas consist of mixed islet cell types, although severe hypoglycemia is usually the major initial symptom.
mesh_terms: D007516:Adenoma, Islet Cell / Q000196:embryology / Q000235:genetics / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010190:Pancreatic Neoplasms / Q000196:embryology / Q000235:genetics / Q000648:ultrastructure*