Wild mouse ecotropic murine leukemia virus infection of inbred mice: dual-tropic virus expression precedes the onset of paralysis and lymphoma.
NFS/N mice inoculated at birth with an ecotropic murine leukemia virus (Cas-Br-MuLV) obtained from wild mice developed hind limb paralysis beginning at 7 weeks of age and nonthymic lymphomas beginning at more than 20 weeks of age. Studies of 1- to 7-week-old Cas-Br-M MuLV-infected mice showed the following: (i) a marked increase in nonecotropic MuLV-related antigens on spleen cells but not thymocytes beginning at 2 weeks; (ii) the appearance of dual-tropic mink cell focus-forming (MCF) MuLV-related gp70 in spleen but not thymus or brain cells at 4 weeks; and (iii) the isolation of infectious MCF MuLV from spleen cells of 7-week-old mice. A role for MCF MuLV in Cas-Br-M MuLV-induced nonthymic lymphomas is indicated by these studies, and a role for recombinant MuLV in neurological disease is considered.
D000818:Animals; D000954:Antigens, Surface; D000956:Antigens, Viral; D006023:Glycoproteins / Q000096:biosynthesis; D009052:Leukemia Virus, Murine / Q000254:growth & development* / Q000276:immunology; D007942:Leukemia, Experimental / Q000382:microbiology*; D008214:Lymphocytes / Q000382:microbiology; D008223:Lymphoma / Q000209:etiology*; D051379:Mice; D008815:Mice, Inbred Strains; D010243:Paralysis / Q000209:etiology*; D014764:Viral Proteins / Q000096:biosynthesis
D000954:Antigens, Surface; D000956:Antigens, Viral; D006023:Glycoproteins; D014764:Viral Proteins