The effect of 6-keto-prostaglandin E1 on human lymphocyte cAMP levels.
6-keto-PGE1 was capable of increasing cyclic AMP levels of peripheral human blood lymphocytes in a dose and time dependent fashion. The response was maximal after 30 min of incubation at 37 degrees C; 1 microgram per ml of 6-keto-PGE1 elevated cyclic AMP levels 5 fold which compares with a 10 fold increase due to PGE1. Thus 6-keto-PGE1 may play a role as a modulator of lymphocyte function.
D000527:Alprostadil / Q000031:analogs & derivatives*; D000242:Cyclic AMP / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology
D011458:Prostaglandins E; C022950:6-ketoprostaglandin E1; D000242:Cyclic AMP; D000527:Alprostadil