title: Metabolic alterations in the synoviocytes in chronically inflamed knee joints in immune arthritis in the rabbit: comparison with rheumatoid arthritis.
abstract: The metabolism of the synovial lining cells of the normal and chronically inflamed joints of rabbits, in the Dumonde and Glynn model of rheumatoid arthritis, has been examined by quantitative cytochemistry. Significant alterations in metabolic activity were found in the synovial lining cells of the chronically inflamed joints. These alterations in metabolic activity closely resemble the pattern of metabolic changes found in human synovial lining cells in rheumatoid arthritis.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000378:metabolism*; D001169:Arthritis, Experimental / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006614:Hindlimb; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D009708:Nucleotidases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D011817:Rabbits; D012016:Reference Values; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology
chemical_list: D010088:Oxidoreductases; D003576:Electron Transport Complex IV; D009708:Nucleotidases