Postnatal development of glycogen- and cyclic AMP-metabolizing enzymes in mammalian skeletal muscle.
Glycogen and cyclic AMP-metabolizing enzymes of rabbit skeletal muscle were examined during postnatal development. Glycogen synthase I, glycogen phosporylase and lactate dehydrogenase activity increased 7-fold by the 6th--8th postnatal week while glycogen synthase D was present in the neonate at one-half adult levels. Cyclic AMP phosphodiesterase decreased; adenylate cyclase increased 10-fold for both the epinephrine and NaF-stimulated states of the enzyme.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D000242:Cyclic AMP / Q000378:metabolism*; D004789:Enzyme Activation; D004837:Epinephrine / Q000494:pharmacology; D005459:Fluorides / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism*; D006006:Glycogen Synthase / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology*; D006005:Phosphorylases / Q000378:metabolism*; D011817:Rabbits
D006003:Glycogen; D000242:Cyclic AMP; D007770:L-Lactate Dehydrogenase; D006005:Phosphorylases; D006006:Glycogen Synthase; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases; D005459:Fluorides; D004837:Epinephrine