title: Functional and metabolic studies of polymorphonuclear leukocytes in the congenital Pelger-Huet anomaly.
abstract: Polymorphonuclear leukocytes (PMNL) from two individuals with congenital Pelger-Huet anomaly (PHA) were examined to determine whether functional or metabolic defects accompanied the known morphological abnormality. No abnormalities of the PHA cells, as compared to normal control cells, were found when tested for quantitative leukocyte enzyme activities, nitroblue tetrazolium reduction, hexose monophosphate shunt activity, superoxide production, generation of chemiluminescence, or iodination. The PHA cells, as compared to normal PMNL, demonstrated normal chemotaxis and random migration, as well as bactericidal activity.
mesh_terms: D000328:Adult; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D005260:Female; D006600:Hexosephosphates / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D008163:Luminescent Measurements; D009504:Neutrophils / Q000378:metabolism / Q000503:physiopathology*; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010381:Pelger-Huet Anomaly / Q000151:congenital*; D013481:Superoxides / Q000096:biosynthesis
chemical_list: D006600:Hexosephosphates; D013481:Superoxides; D009580:Nitroblue Tetrazolium