title: Rotavirus, adenovirus, and non-viral enteropathogens in diarrhoea.
abstract: The aetiology of rotavirus and adenovirus in acute gastroenteritis was studied in a prospective series that comprised 283 children admitted consecutively with diarrhoea during a 1-year period. Rotavirus was associated in 49% of the cases by solid-phase radioimmunoassay and electron microscopical examination of stool specimens, or by serology. Adenovirus was detected by radioimmunoassay in the stool specimens of 29 (11%) patients, including 8 cases of possible dual infection with rotavirus. Rotavirus infections showed a typical age distribution and seasonal clustering between January and June, whereas the adenovirus-associated cases did not form a distinctive subgroup. Enteropathogenic bacteria were found in 10% of cases, and were nearly as common in association with rotavirus infection as not. Respiratory symptoms accompanied diarrhoea in 34% of the patients with rotavirus and in 25% of those with neither rotavirus nor adenovirus. Therefore we could not confirm the existence of a 'rotavirus syndrome', nor could we confirm an association of respiratory symptoms with rotavirus infection. Use of antibiotics before the onset of diarrhoea was more common among those with non-viral diarrhoea (23%) than in the rotavirus group (13%). Rotavirus infections appeared to be common among cases of 'antibiotic-induced' diarrhoea.
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications*; D000258:Adenovirus Infections, Human / Q000150:complications*; D000293:Adolescent; D000367:Age Factors; D001424:Bacterial Infections / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000150:complications / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011446:Prospective Studies; D011863:Radioimmunoassay; D012088:Reoviridae Infections / Q000150:complications*; D012141:Respiratory Tract Infections / Q000150:complications; D012401:Rotavirus; D012621:Seasons