title: [Seronegative systemic lupus erythematosus (author's transl)].
abstract: Seronegative systemic lupus erythematosus is defined as a SLE devoided of antinuclear factors as well as of LE cells when at least 4 out of the 14 ARA criteria are present. We describe herein two case reports and review previous literature concerning this topic. This kind of SLE is characterized by a high incidence of Raynaud's disease, photosensitivity, oral ulcerations, alopecia and perhaps less frequent kidney and central nervous system involvement. The hypotheses about the absence of ANF are discussed. The awareness of such a SLE ("devoided of ANF rather than" seronegative") is to be kept in mind from a chemical, therapeutic and pathophysiologic point of view.
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D012698:Serologic Tests
chemical_list: D000974:Antibodies, Antinuclear
vernacular_title: Lupus erythèmateux dissèminè Sèronègatif.