[Changes in the activity of cyclic nucleotide phosphodiesterase and content of rhodopsin in retina during long illumination].
The phosphodiesterase activity in rat retina is found to decrease after a relatively short (1 h) and long (24 and 48 h) light exposition at 1200-1700 lx. illumination. The degree of decrease in the enzymic activity correlates with the exposure time. The rhodopsin capacity for regeneration is a criterion of the activity changes in the retina under the light effect. An hour illumination after the dark adaptation restores practically the initial level of the rhodopsin content and phosphodiesterase activity. A one- and two-day stay in the light causes a partial disturbance in the regeneration of rhodopsin and essential disturbances of the phosphodiesterase activity recovery in the retina.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000378:metabolism*; D000818:Animals; D003624:Darkness; D008027:Light; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D012160:Retina / Q000378:metabolism*; D012168:Retinal Pigments / Q000378:metabolism*; D012243:Rhodopsin / Q000378:metabolism*
D012168:Retinal Pigments; D012243:Rhodopsin; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases
Izmenenie aktivnosti fosfodiésterazy tsiklicheskikh nukleotidov i soderzhaniia zritel'nogopigmenta v setchatke pri dlitel'nom osveshchenii.