Experimental studies on TDI dermatitis in mice.
Allergic contact dermatitis occurred with 2, 4-toluene diisocyanate (TDI) in BALB/c mice. The results were obtained by the measurement of the ear thickness after challenged to the ear with 1% TDI in olive oil in mice previously sensitized with 5% TDI. The ear swelling rate at 48 hr postchallenge in sensitized mice was more than twice of that in unsensitized mice. In BALB/c-nu/nu (nude) mice, delayed type hypersensitivity could not be induced even when a 30% TDI solution was applied. These results suggest that T cells may play an essential role in contact sensitivity to TDI in BALB/c mice.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003485:Cyanates / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000473:pathology*; D009783:Dermatitis, Occupational / Q000209:etiology; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000473:pathology; D014051:Toluene 2,4-Diisocyanate / Q000633:toxicity*
D003485:Cyanates; D014051:Toluene 2,4-Diisocyanate