Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids.
Stimulation of the beta-adrenergic receptor increases the enzymatic methylation of membrane phospholipids. Increased synthesis of phosphatidyl-N-monomethylethanolamine by methyltransferase I increases fluidity and enhances the ability of the beta-adrenergic receptor to couple with adenylate cyclase. The number of beta-adrenergic receptors can be regulated by the rate of synthesis and of degradation of phosphatidylcholine formed by transmethylation.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D008051:Lipid Bilayers; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000502:physiology*; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism*; D010743:Phospholipids / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012156:Reticulocytes / Q000378:metabolism
D008051:Lipid Bilayers; D008563:Membrane Lipids; D010743:Phospholipids; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D008780:Methyltransferases; D007545:Isoproterenol