Studies of platelet monoamine oxidase activity in Epstein-Barr and dengue virus infections.
As part of a prospective, psychosocial, and biochemical study of infectious mononucleosis, platelet monoamine oxidase (MAO) activity has been evaluated as a host factor. It was found that platelet MAO activity may be a possible predisposing host factor but not a precipitating factor. The results on infectious mononucleosis, a viral disease which involves the host's cell-mediated immune system, are compared with an evaluation of platelet MAO activity in dengue, a viral disorder involving the host's humoral immune system. The platelet MAO activity in these disorders has been compared to that in schizophrenia, a disease for which low platelet MAO activity has been postulated, from retrospective and twin studies, to be a risk factor. One hypothesis suggests that low platelet MAO activity predisposes to development of schizophrenia, but also increases cell-mediated immune system responses.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D001792:Blood Platelets / Q000201:enzymology*; D003715:Dengue / Q000201:enzymology* / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000201:enzymology* / Q000276:immunology; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood*
D000914:Antibodies, Viral; D008995:Monoamine Oxidase