title: Observations on the level of cyclic nucleotides in three population of human lymphocytes in culture.
abstract: The level of cyclic nucleotides in three populations of cultured human lymphocytes were studied. An early conspicuous elevation of c-GMP level and a reciprocal relationship between c-AMP and c-GMP fluctuations were demonstrated in T cells from normal donors. Null cells from patients with ALL showed a constantly low level of c-AMP, while c-GMP fluctuated in apparent relationship with cell doubling time. Persistently low levels of c-AMP and persistently high level of c-GMP were found in B cells from patients with CLL. Possible significance of these findings is discussed.
mesh_terms: D001402:B-Lymphocytes / Q000032:analysis; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood*; D008214:Lymphocytes / Q000032:analysis*; D013601:T-Lymphocytes / Q000032:analysis
chemical_list: D000242:Cyclic AMP; D006152:Cyclic GMP