[Comparative study of the antiviral activity of pancreatic and microbial RNAse].
The efficacy of pancreatic RNase with microbial enzymes (RN-ases) of Act. rimosus and Bacillus intermedius) was studied comparatively in vitro in a transplantable cell culture of the swine embryokidney with respect to the aphthosa virus (AV) and the virus of the Aujeszky disease (VAD). The VAD proved to be most sensitive to RNases. RNase of Bac. intermedius showed the highest antiviral efficacy. The enzymes were active in vivo, when the albino mice and newborn rabbits were infected with the AV, the RNase of Bac. intermedius being also most active in this case.
D000818:Animals; D000831:Animals, Newborn; D000998:Antiviral Agents; D005537:Aphthovirus / Q000187:drug effects*; D001407:Bacillus / Q000201:enzymology*; D004353:Drug Evaluation, Preclinical; D005536:Foot-and-Mouth Disease / Q000188:drug therapy; D011558:Herpesvirus 1, Suid / Q000187:drug effects*; D066298:In Vitro Techniques; D051379:Mice; D010179:Pancreas / Q000201:enzymology*; D011817:Rabbits; D012260:Ribonucleases / Q000627:therapeutic use*; D013302:Streptomyces / Q000201:enzymology*; D014776:Virus Cultivation
D000998:Antiviral Agents; D012260:Ribonucleases
Sravnitel'noe izuchenie protivovirusnoĭ aktivnosti pankreaticheskoĭ i mikrobnykh RNK-az.