title: Pituitary gastrins occur in corticotrophs and melanotrophs.
abstract: The gut hormone gastrin was identified in pituitary cells containing adrenocorticotropic hormone and alpha-melanocyte--stimulating hormone by region-specific immunocytochemistry and radioimmunoassay. Smaller amounts of gastrin were found in nerve fibers of the neural lobe and pituitary stalk. Since adrenocorticotropic hormone--like peptides occur in antropyloric gastrin cells, these data indicate a considerable similarity in peptide composition of pituitary and gastrointestinal endocrine cells and reinforces questions of multiple hormone production.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002415:Cats; D005755:Gastrins / Q000235:genetics / Q000378:metabolism*; D006651:Histocytochemistry; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism*; D011863:Radioimmunoassay; D013552:Swine
chemical_list: D005755:Gastrins; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones