A study on beta-adrenergic receptors in children with asthmatic bronchitis.
The function of beta-adrenergic receptors was assessed in 50 children with asthmatic bronchitis and 45 healthy controls by the hyperglycemic, eosinopenic and platelet aggregation responses to epinephrine. The results showed evidence of beta-adrenergic blockade in children with asthmatic bronchitis. It is suggested that this blockade may reflect a functional and/or a structural immaturity of the beta receptors in these children.
D001249:Asthma / Q000503:physiopathology*; D001786:Blood Glucose; D002675:Child, Preschool; D004804:Eosinophils; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D001786:Blood Glucose; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004837:Epinephrine