[Inhibition by methyl mercury chloride and mercuric chloride of the in vitro polymerization of microtubules].
Mercury was tested at the same concentration but under two different forms, organic CH3HgCl and inorganic HgCl2, in order to compare its relative inhibitory effect on in vitro microtubules polymerization. Induced by GTP and glycerol 8 M, tubulin polymerization was completely inhibited by HgCl2 10(-3) M while a 75.8% inhibition was measured for CH3HgCl2 10(-3) M.
D066298:In Vitro Techniques; D008627:Mercuric Chloride / Q000494:pharmacology*; D008767:Methylmercury Compounds / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects*; D014404:Tubulin
D008767:Methylmercury Compounds; D014404:Tubulin; D008627:Mercuric Chloride; C004925:methylmercuric chloride
Inhibition par le chlorure de méthyl mercure et le chlorure de mercure de la polymérisation in vitro des microtubules.