title: Circadian patterns of growth hormone, prolactin and corticotrophin secretion in hypothalamic and extra-hypothalamic lesions localized by stereotactic neuro-radiology in humans.
abstract: The integrity of mediobasal hypothalamus for the maintenance of normal circadian rhythms has been clearly established in the animal. Using precise stereotactic neuroradiologic localisations of various brain tumors, the authors demonstrate that in human, cortical lesions induce no significant modifications of the circadian variation of GH, prolactin or ACTH. In contrast subcortical lesions displacing the 3rd ventricle result in an inhibiton of the nocturnal rise in GH and prolactin, whereas the circadian rhythm of ACTH remains normal.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D001932:Brain Neoplasms / Q000503:physiopathology; D002940:Circadian Rhythm; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism*
chemical_list: D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone