Hypercalcemia secondary to a pseudoparathormone-secreting ameloblastoma.
An unusual case of hypercalcemia associated with an ameloblastoma occurred. The sequence of recurring ameloblastoma, increased serum calcium levels and urinary cyclic adenosine monophosphate (cAMP) levels, removal of the tumor, and decrease of those levels to normal suggests that the ameloblastoma was secreting a parathormone-like substance that, in turn, was stimulating the production of nephrogenous cAMP and elevating the serum calcium level.
D000564:Ameloblastoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000242:Cyclic AMP / Q000652:urine; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008339:Mandibular Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D010281:Parathyroid Hormone / Q000378:metabolism*
D010281:Parathyroid Hormone; D000242:Cyclic AMP