Effect of stress and ACTH on dopamine metabolism in the nucleus accumbens and frontal cortex.
The effect of ACTH and electric foot shock stress on DOPAC content were determined in the frontal cortex and nucleus accumbens. Twenty min of stress enhanced DOPAC levels in the frontal cortex and in the nucleus accumbens by about 80% and 35%, respectively. On the other hand, a single dose of ACTH failed to change DOPAC concentration in the above brain areas. The present results show that the activation of mesolimbic and mesocortical dopaminergic systems is not mediated by ACTH secretion.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology*; D004597:Electroshock / Q000009:adverse effects*; D005625:Frontal Lobe / Q000378:metabolism; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D012686:Septal Nuclei / Q000378:metabolism*; D013312:Stress, Physiological / Q000150:complications*
D000324:Adrenocorticotropic Hormone; D004298:Dopamine