A fixed charge system as a formal model for the behaviour of smooth muscles and the heart.
An extension of the theory of the "fixed charge" controlled "membrane oscillator" is used for simulation of a variety of excitability phenomena in nerves, presso-receptors, smooth muscle and the heart. A central issue is the prediction of water movements across the cell membrane resulting in "swelling" and "shrinkage". The presented "electrohydraulic excitability analog" (EHEA) deals particularly with the generation of action potentials, volume-pressure changes and contractility in response to externally applied mechanical stimuli, i.e. the EHEA is applied as a pressoreceptor analog. The agreement between the theoretical model results and some experimental physiological observations cited from the literature is quite satisfactory.
D000818:Animals; D002463:Cell Membrane Permeability; D005110:Extracellular Space / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006372:Helix, Snails; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials; D009119:Muscle Contraction; D009470:Muscle Spindles / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D009200:Myocardial Contraction; D011311:Pressoreceptors / Q000502:physiology
D007473:Ion Channels