title: Influence of sex hormones on the subcellular distribution of copper in sheep liver.
abstract: At the 14th to 16th week of pregnancy the copper content in the maternal liver was low while that in the fetus was high. After ovariectomy there was a decrease in liver copper and ceruloplasmin which was prevented by treatment with oestrogens but not with progesterone. Five groups of sheep were studied: control (barren ewes), pregnant, ovariectomised and ovariectomised treated with oestrogens or progesterone. In all, with high or low liver copper, the nuclear fraction contained the most copper. This suggests a species specificity of the copper metabolism in sheep.
mesh_terms: D000818:Animals; D002570:Ceruloplasmin / Q000032:analysis; D003300:Copper / Q000097:blood / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D006589:Hexestrol / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D012756:Sheep / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D006589:Hexestrol; D011374:Progesterone; D003300:Copper; D002570:Ceruloplasmin