title: Effect of hypothermia during ischemia on myocardial contractility in nonhypertrophied and hypertrophied ventricles.
abstract: The effect of hypothermic ischemic arrest on myocardial contractility was investigated with use of isolated blood-perfused canine heart preparation in the hypertrophied left ventricle created by supravascular aortic stenosis and the non-hypertrophied ventricle. The following results were obtained: The percent recovery rate of net developed tension during reperfusion after an ischemic period of 150 minutes at the myocardial temperature of 17 degrees C was 90 +/- 9% in the non-hypertrophied muscle, that is, hypertrophied left ventricle was considered to be more vulnerable to ischemia as compared to nonhypertrophied left ventricle, suggesting the necessity of more intense myocardial protection in addition to cardiac hypothermia against ischemia in the hypertrophied heart.
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology*; D003326:Coronary Circulation; D000242:Cyclic AMP / Q000032:analysis; D004285:Dogs; D005260:Female; D007036:Hypothermia, Induced; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000032:analysis; D010477:Perfusion
chemical_list: D000242:Cyclic AMP