Immunofluorescent localization of cyclic GMP, calmodulin and cyclic GMP-dependent protein kinase in the choroid plexus.
An immunofluorescent technique has demonstrated that tissue-bound pools of cyclic GMP, calmodulin and cyclic GMP-dependent protein kinase are localized within the cytoplasm of the epithelial cells of the choroid plexus. In all other cell types and regions of the central nervous system previously examined, however, these molecules have shown contrasting immunofluorescent localization. These results suggest that the interaction in the choroid plexus may be related to the specialized physiological functions of the neuroglial epithelial cell.
D000818:Animals; D002135:Calcium-Binding Proteins / Q000032:analysis*; D002147:Calmodulin / Q000032:analysis*; D002831:Choroid Plexus / Q000032:analysis* / Q000201:enzymology; D006152:Cyclic GMP / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D008297:Male; D011494:Protein Kinases / Q000032:analysis*; D051381:Rats
D002135:Calcium-Binding Proteins; D002147:Calmodulin; D011494:Protein Kinases; D006152:Cyclic GMP