Pagetoid reticulosis: a disease of histiocytic origin.
A patient with Pagetoid reticulosis has been investigated using standard transmission electron microscopy and an immunohistochemical technique for identifying T lymphocytes in situ in light and electron microscopy. Our results indicate that the majority of the cells in the underlying dermal infiltrate are T lymphocytes but that only very few T lymphocytes are found in the extensive epidermal infiltrate. Ultrastructurally the majority of the abnormal cells in the epidermis are of histiocytic origin.
D006644:Histiocytes / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D008206:Lymphatic Diseases / Q000276:immunology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000276:immunology / Q000648:ultrastructure*; D012867:Skin / Q000276:immunology / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000276:immunology / Q000648:ultrastructure*; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure