[An experimental study of veralipride (author's transl)].
The administration of doses of 0,001, 0, 01, 0,1, and 1 mg/kg/day of veralipride to female rats produces a dose-related blocking effect on dioestrus. No histological changes are noted in the genital tract and mammary gland tissues after 0,001 and 0,01 mg/kg/day. Doses of 0,1 and 1 mg/kg/day block ovulation and the resulting estrogen impregnation modifies the appearance of the uterine glands and vaginal epithelium. Mammotropic effects, seen as a moderate hyperplasia but without galactogenic secretion, occur after 1 mg/kg/day only.
D000818:Animals; D004031:Diestrus / Q000187:drug effects; D004971:Estrus / Q000187:drug effects; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology; D011247:Pregnancy; D051381:Rats; D013469:Sulpiride / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014599:Uterus / Q000033:anatomy & histology; D014621:Vagina / Q000033:anatomy & histology
D013469:Sulpiride; C027429:veralipride
Expérimentation du véralipride chez la ratte. Etude expérimentale et histologique.