The morphology of early trophoblast after dioxin poisoning in the Seveso area.
The placental morphology in 22 cases of induced abortion performed one to three months after the Seveso disaster is described. In 15 cases no gross histological or ultrastructural alterations were observed. In seven cases there were many prominent microprecipitates beneath the trophoblastic basement membrane at various distances from the fetal capillaries. Intermediate patterns between simple dense bodies, already well known, and complex pluri-stratified giant structures not previously reported have been described. Combined ultrastructural and x-ray investigations (EDAX analysis) have recorded calcium- and iron-related emissions from these structures. The significance of these findings and their possible relationship to dioxin poisoning has been discussed.
D000032:Abortion, Therapeutic; D004147:Dioxins / Q000506:poisoning*; D004577:Electron Probe Microanalysis; D004787:Environmental Pollution; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D007558:Italy; D008854:Microscopy, Electron; D010920:Placenta / Q000648:ultrastructure; D000072317:Polychlorinated Dibenzodioxins / Q000506:poisoning*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014327:Trophoblasts / Q000187:drug effects / Q000648:ultrastructure*
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins