Morphologic probes of polypeptide hormone receptor interactions.
Polypeptide hormones, growth factors, and a variety of other naturally occurring ligands bind specifically to receptors on the cell surface. At physiologic temperatures these ligands are internalized by cells and associate intracellularly with lysosomes. Receptor-mediated internalization provides a simple mechanism that may act to couple receptor-mediated hormone degradation with receptor-medicated receptor regulation.
D000818:Animals; D004705:Endocytosis; D013006:Growth Hormone / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D006651:Histocytochemistry; D007328:Insulin / Q000378:metabolism*; D008099:Liver / Q000276:immunology / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D051379:Mice; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*
D006133:Growth Substances; D007328:Insulin; D011956:Receptors, Cell Surface; D013006:Growth Hormone