Cholecystokinin and satiety in pigs.
Twenty-three pigs, 1-3 mo of age, were fitted variously with intraperitoneal, intrajugular, intraportal, and intraduodenal catheters. After a 4-h fast, porcine cholecystokinin (CCK), 5-40 Ivy dog units/kg body wt (IDU/kg); caerulein, 0.25-2 micrograms/kg; or the octapeptide of cholecystokinin (CCK-OP), 5-40 IDU/kg, was given parenterally; or 2-5% sodium oleate or 5% protein hydrolysate (5 ml/kg) was injected intraduodenally. Pelleted feed intake was then measured for 10 min. Food intake was depressed in a dose-related fashion in all instances as compared to after 0.9% NaCl control injections. For example, feed consumption following 5 and 40 IDU/kg of CCK intrajugularly was 84 +/- 2 and 6 +/- 4 (SE) %, respectively, of control intake. Intraportal infusion produced a greater depression of feeding. A conditioned taste aversion could not be formed to CCK, caerulein, or CCK-OP. Sodium oleate or protein hydrolysate, releasers of endogenous CCK, depressed feeding, and this satiety effect was attenuated when given with 0.5% tetracaine. The results support the hypothesis that CCK participates in rapid, presumably preabsorptive, satiety.
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002108:Ceruletide / Q000494:pharmacology; D002766:Cholecystokinin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D004386:Duodenum; D005260:Female; D007263:Infusions, Parenteral; D007267:Injections; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000502:physiology; D008297:Male; D012527:Satiation / Q000187:drug effects*; D012844:Sincalide; D013552:Swine; D013649:Taste / Q000187:drug effects
D000779:Anesthetics, Local; D002108:Ceruletide; D002766:Cholecystokinin; D012844:Sincalide