title: The effects of intrathecal sympathomimetic agents on neural activity in the lumbar sympathetic chain of rats.
abstract: Intrathecal injections of norepinephrine (0.30 mumol) and clonidine (0.035 mumol) produced decreases in neural activity recorded from the lumbar sympathetic chain and caused changes in rat thermoregulation consistent with a reduction in efferent sympathetic activity. These results support the conclusion that bulbospinal noradrenergic pathways inhibit sympathetic outflow. The data also indicate that the spinal cord is a potential site of action for clonidine.
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D007278:Injections, Spinal; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D003000:Clonidine; D009638:Norepinephrine