[The absorption of homologous alkyl sulphonates of tridihexethyl (author's transl)].
The pharmaceutical-technological measure of varied salt formation acts on the in vivo diffusion processes of quaternary tridihexethyl (gastro-intestinal absorption, transperitoneal diffusion) in principle in the same manner as it acts on the in vitro diffusion processes (membrane diffusion): Due to the formation of corresponding ion pairs, lipophilic counterions of opposite sign facilitate the passage through membranes. In contrast, the direct pharmacodynamic activity (spasmolysis at the isolated jejunum of the rat) is not changed by varying the counterions of opposite sign.
D000042:Absorption; D000476:Alkanesulfonates / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D007700:Kinetics; D007928:Lethal Dose 50; D051379:Mice; D008954:Models, Biological; D009119:Muscle Contraction / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D000476:Alkanesulfonates; D000644:Quaternary Ammonium Compounds
Resorption homologer Alkylsulfonate des Tridihexethyls.