Failure of ketamine to interact with opiate receptors.
Ketamine, an anesthetic agent endowed with several morphine-like effects, failed to displace 3H-dihydromorphine or 3H-methionine-enkephalin from opiate receptors in the rat brain synaptosomal-mitochondrial membrane preparations. Furthermore, ketamine-induced analgesia in rats was not antagonized by naloxone, suggesting that this effect is not mediated by opiate receptors.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D004090:Dihydromorphine / Q000378:metabolism; D066298:In Vitro Techniques; D007649:Ketamine / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects*; D013574:Synaptosomes / Q000378:metabolism
D011957:Receptors, Opioid; D009270:Naloxone; D007649:Ketamine; D004090:Dihydromorphine