Management of the more common pediatric neoplasms with particular reference to Hodgkin's and non-Hodgkin's lymphoma, Wilms' tumour and neuroblastoma.
Accurate pathological diagnosis and staging of extent of disease are key steps in the management of childhood neoplasms. Adjuvant chemotherapy is responsible for improved survival rates. In non-Hodgkin's lymphoma intensive chemotherapy, irradiation to areas of bulk disease and central nervous system prophylaxis are combined in treatment. Chemotherapy and limited field irradiation have improved survival in Hodgkin's disease. Treatment varies widely in neuroblastoma according to stage with disseminated disease still carrying a very poor prognosis. Survival in Wilms' tumour has improved to such an extent that long-term side-effects of therapy now need to be considered.
D000970:Antineoplastic Agents / Q000008:administration & dosage; D002648:Child; D004359:Drug Therapy, Combination; D006689:Hodgkin Disease / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary; D009447:Neuroblastoma / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D009396:Wilms Tumor / Q000473:pathology / Q000628:therapy*
D000970:Antineoplastic Agents