title: Sodium ions increase the affinity of clonidine for alpha 1-adrenoceptors in rat brain.
abstract: alpha 1-Adrenoceptors in rat brain membranes, labeled by the antagonist [3H] prazosin, increase their affinity for clonidine several-fold when sodium ions are added. The conversion of alpha 1-adrenoceptors, buy sodium ion, into a conformation, which has higher affinity for the agonist clonidine, indicates that these receptors as the alpha 2-adrenoceptors are modulated by cations in vitro.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003000:Clonidine / Q000378:metabolism*; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology
chemical_list: D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D012964:Sodium; D003000:Clonidine; D011224:Prazosin