[Changes in cyclic AMP concentration of the rat preoptic region as a result of long term exposure to cold].
The cAMP concentration in the preoptic region was studied in rats during exposure to low ambient temperature (Ta: -10 degrees C) and after return to control Ta (22 degrees C). With respect to control cAMP concentration, changes were observed consisting of a decrease (delta cAMP: 4.19 /+- 0.15 pM/mg Pr; p < 0.001) at low Ta and an increase (delta cAMP: 1.40 /+- 0.13 pM/mg Pr; P < 0.05) after return to control Ta. In contrast, cortical cAMP concentration decreased both at low Ta (delta cAMP: 2.94 /+- 0.09 pM/mg Pr; P < 0.005) and after return to control Ta (delta cAMP: 3.21 /+- 0.09 pM/mg Pr; P < 0.001). such cAMP changes in the preoptic region may be related to different activation levels of thermoregulatory and sleep mechanisms.
D000818:Animals; D001833:Body Temperature Regulation; D003080:Cold Temperature; D000242:Cyclic AMP / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D011301:Preoptic Area / Q000378:metabolism*; D051381:Rats; D012890:Sleep / Q000502:physiology; D013997:Time Factors
D000242:Cyclic AMP
Modificazioni della concentrazione di AMP ciclico nella regione preottica del ratto per effetto della esposizione prolungata al freddo.