title: Postnatal development of estradiol receptor in female and male rats.
abstract: The concentration of available cytoplasmic estradiol receptor was quantified in the postnatal hypothalamus and pituitary of male and female rats, aged from 4 to 28 days. The uterine receptor was measured in female rats. The method used was designed to avoid non-specific contamination of cytosol from very young animals by plasma proteins, especially alpha-feto-protein (AFP). In the hypothalamus, the concentration of estradiol binding sites was maximal 6 days after birth, and declined until day 28 to low constant level. In the pituitary, the estradiol receptor concentration increased from day 4 and reached a plateau at 13--14 days, whereas in the uterus, the concentration of cytoplasmic binding sites rose up to day 10--12, and then markedly decreased.
mesh_terms: D000375:Aging; D000818:Animals; D004958:Estradiol / Q000378:metabolism*; D004967:Estrogens / Q000097:blood; D005260:Female; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D010902:Pituitary Gland / Q000032:analysis; D051381:Rats; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D014599:Uterus / Q000032:analysis
chemical_list: D004967:Estrogens; D011956:Receptors, Cell Surface; D004958:Estradiol