[Model of the selective calcium channel of characean algae].
The present work was intended to further investigate the selective filter of calcium channel on both a cell membrane and reconstructed channels. For the studies on cell membranes, an inhibitor of chloride channels was chosen (ethacrynic acid) to pass currents only through the calcium channels. On both the cells and reconstructed channels, permeability of ions of different crystal radii and valencies was investigated. The obtained results suggest that the channel represents a wide water pore with a diameter larger than 8 A into which ions go together with the nearest water shell. The values of the maximal currents are given by electrostatic interaction of the ions with the anion center of the channel. A phenomenological two-barrier model of the channel is given which describes the movement of all the ions studied.
D002118:Calcium / Q000378:metabolism*; D002412:Cations; D000460:Chlorophyta / Q000378:metabolism*; D004976:Ethacrynic Acid / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological
D002412:Cations; D007473:Ion Channels; D004976:Ethacrynic Acid; D002118:Calcium
Model' selektivnogo kal'tsievogo kanala kletok kharovoĭ vodorosli.