title: The lack of affinity of prostaglandins to dopaminergic and opiate receptors in the rat striatum.
abstract: The aim of this paper was to study whether prostaglandins (PGs) E1, E2 and F2 alpha affect the binding of specific ligands for dopaminergic or opiate receptors 3H-spiroperidol or 3H-naloxone in the rat striatum. The PGs, even in very high concentrations, did not change 3H-spiroperidol or 3H-naloxone binding to rat striatal membranes in vitro. This indicates that in the striatum of rats PGs do not interact directly with dopaminergic and opiate receptors.
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D011957:Receptors, Opioid / Q000187:drug effects* / Q000378:metabolism
chemical_list: D011453:Prostaglandins; D011954:Receptors, Dopamine; D011957:Receptors, Opioid