title: Stimulation of human polymorphonuclear leukocyte superoxide anion radical production by tumor promoters.
abstract: Comparison was made of the ability of the potent tumor promoter phorbol myristate acetate (PMA), as well as less active PMA analogs and non-phorbol ester tumor promoters, to stimulate superoxide anion radical (O-.2) production by human polymorphonuclear leukocytes (PMN). The rate of O-.2 production was found to correlate with the tumor-promoting activity of the phorbol esters as opposed to their inflammatory activity. Mezerein and telocidin B were slightly better stimulators of O-.2 production than PMA. Acetic acid was inactive. These data are discussed in terms of a possible role for O-.2 and other reactive oxygen species in tumor promotion.
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000139:chemically induced; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010100:Oxygen / Q000096:biosynthesis*; D010704:Phorbols / Q000633:toxicity*; D013481:Superoxides / Q000096:biosynthesis*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
chemical_list: D010704:Phorbols; D013481:Superoxides; D013755:Tetradecanoylphorbol Acetate; D010100:Oxygen