title: Ascorbic acid inhibition of Na,K-adenosine triphosphatase of rat forebrain without peroxidation of membrane lipids.
abstract: Using reagents and membrane preparations from which contamination had been carefully removed, we found that ascorbic acid inhibited rat brain Na,K-ATPase without causing lipid peroxidation, unlike the conventional belief; the inhibition was prevented by catecholamines and EGTA. Ascorbic acid radicals, instead of active oxygen, may play a role in the inhibition.
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003600:Cytosol / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013574:Synaptosomes / Q000187:drug effects
chemical_list: D008054:Lipid Peroxides; D008563:Membrane Lipids; D004533:Egtazic Acid; D000255:Adenosine Triphosphate; D000254:Sodium-Potassium-Exchanging ATPase; D001205:Ascorbic Acid; D004298:Dopamine