HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.
The specificity of cytotoxic T cells generated in Epstein-Barr virus (EBV)-infected lymphocyte cultures was investigated, using a 51Cr release assay. Potent cytotoxic T cells with preferred specificity directed to antigens expressed on autologous lymphoblastoid cell line (LCL) target cells were present in 14-day cultures of lymphocytes from EBV-seropositive donors and not from seronegative donors. Moreover, the cytotoxic patterns obtained with a panel of HLA antigen-related and unrelated LCL target cells, supported by unlabeled target inhibition tests, strongly indicate that T cell cytotoxicity to EBV is restricted to HLA antigens.
D000954:Antigens, Surface; D002051:Burkitt Lymphoma / Q000276:immunology; D002460:Cell Line; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D006680:HLA Antigens