title: Chromosome counts of 90Sr-induced osteosarcomas in mice. III. Variation of the chromosome counts of in vivo transplanted tumours, in vitro cultures and retransplanted cultured cells.
abstract: This investigation started from serially in vivo transplanted tumours. The chromosome patterns of in vitro cultures and of parallelly and serially transplanted tumours were examined. Cultured cells were also used for retransplantation to mice. When comparing the chromosome counts of the cultured cells and the in vivo transplanted tumours, significant differences were revealed. When retransplanting cultured cells, it was also noticed that a similar chromosome distribution appeared, as previously found in 90Sr-induced transplanted series.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000235:genetics; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D012516:Osteosarcoma / Q000235:genetics*; D013326:Strontium Radioisotopes / Q000009:adverse effects*; D014184:Transplantation, Homologous
chemical_list: D013326:Strontium Radioisotopes