Hypertension, vasculature and aging.
Essential hypertension is the most common disease which develops with advancing age, and its complication, arteriosclerosis, seems to be an exaggerated form of aging process in the mesenchymal tissues. Our present investigation demonstrated that deposition of collagen fibers in vessel wall may represent one aspect of the aging phenomenon occurring in normal vasculature.
D000375:Aging; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001808:Blood Vessels / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D003900:Desoxycorticosterone / Q000494:pharmacology; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology
D000959:Antihypertensive Agents; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase