Pattern of immunoreactive glucagon in portal, arterial and peripheral plasma before and after removal of glucagonoma.
Gel fractionation of portal, arterial and peripheral plasma glucagon levels was performed before and after the successful removal of a glucagonoma. A 47 year old woman had symptoms of dermatitis, weight loss, anemia and diabetes mellitus over a 16 year period. Removal of the alpha-cell tumor corrected all of her symptoms. Gel filtration of portal, arterial and peripheral blood showed two peaks of glucagon radioimmunoassay activity, a higher molecular weight glucagon with a molecular weight of 9,000 and a 3,500 dalton glucagon. Five minutes after tumor removal, the higher molecular weight glucagon had disappeared completely from the arterial and peripheral blood but not from the portal vein.
D007516:Adenoma, Islet Cell / Q000276:immunology* / Q000601:surgery; D000941:Antigens; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D005260:Female; D005934:Glucagon / Q000097:blood / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D008970:Molecular Weight; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000601:surgery; D011169:Portal Vein; D052336:Proglucagon; D011498:Protein Precursors / Q000097:blood; D011863:Radioimmunoassay
D000941:Antigens; D011498:Protein Precursors; D052336:Proglucagon; D005934:Glucagon