The beta-adrenoreceptor in human lymphocytes.
The beta-adrenoreceptors of human lymphocytes were investigated by binding assays using a radiolabelled beta-adrenoreceptor agonist, 3H-hydroxybenzylisoproterenol, in an intact cell system. Intact human lymphocytes had binding sites for the ligand, which seemed to represent physiological beta-adrenoreceptors. Thus, assay of binding of the beta-adrenergic agonist, 3H-HBI, by intact lymphocytes can be used to study beta-adrenoreceptors in human tissue and to elucidate possible beta-adrenoreceptor disorders in human diseases.
D006801:Humans; D007545:Isoproterenol / Q000031:analogs & derivatives; D008214:Lymphocytes / Q000032:analysis*; D011869:Radioligand Assay; D011941:Receptors, Adrenergic / Q000032:analysis*; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; C015272:hydroxybenzylisoproterenol; D007545:Isoproterenol