title: Pharmacological researches on 2-(7'-theophyllinemethyl)1,3-dioxolane.
abstract: The main pharmacological activities of 2-(7'theophyllinemethyl)-1,3-dioxolane (ABC 12/3), a new theophyllinic derivative, were studied. This compound was shown to possess an extremely high anti-bronchospastic activity in vitro and in vivo, its effectiveness being much greater than that of theophylline; and it also showed a strong activity as an antitussive on experimental cough induced by citric acid or histamine aerosol. However the compound showed little activity on the intestinal smooth muscle, the cardiovascular and the central nervous systems. The acute toxicity of ABC 12/3 is rather low and therefore it should be possible to utilize it for therapeutic purposes in tracheobronchial diseases.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000779:Anesthetics, Local; D000818:Animals; D000996:Antitussive Agents; D001986:Bronchial Spasm / Q000517:prevention & control; D002490:Central Nervous System / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D009130:Muscle, Smooth / Q000187:drug effects; D011817:Rabbits; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000779:Anesthetics, Local; D000996:Antitussive Agents; D013806:Theophylline; D015105:3',5'-Cyclic-AMP Phosphodiesterases; C029797:doxofylline