Inhibition of polyoma virus-specific RNA formation by 5-bromo-2'-deoxyuridine.
The synthesis of polyoma (Py) virus-specific RNA, assayed by molecular hybridization at late phase of infection of mouse embryo (ME) cells is inhibited by 5-bromo-2'-deoxyuridine (BrdUrd). 0.25-12.68 microgram/ml BrdUrd causes an inhibition to about 60-10% of the control, respectively.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D004279:DNA, Viral / Q000378:metabolism; D051379:Mice; D009153:Mutagens; D011120:Polyomavirus / Q000187:drug effects* / Q000378:metabolism; D012367:RNA, Viral / Q000096:biosynthesis*; D014158:Transcription, Genetic / Q000187:drug effects
D004279:DNA, Viral; D009153:Mutagens; D012367:RNA, Viral; D001973:Bromodeoxyuridine