Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change.
3H-HSV-2 DNA has been hybridized in situ to frozen sectioned tissue from human cervical biopsies. RNA complementary to the virus-specific probe was detected in cells undergoing pre-malignant changes, but not in the cells of the fully developed squamous-cell cancer.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000032:analysis; D002642:Chick Embryo; D004279:DNA, Viral; D005260:Female; D005814:Genes, Viral; D006801:Humans; D066298:In Vitro Techniques; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis*; D018139:Simplexvirus; D002583:Uterine Cervical Neoplasms / Q000032:analysis*
D004279:DNA, Viral; D012367:RNA, Viral