Increased growth of RSV-induced tumors in chickens partially tolerant to MHC alloantigens.
Chickens with B2B2 MHC genotypes were made partically tolerant to B5 MHC cell-surface antigens and the fate of their Rous-sarcoma-virus (RSV)-induced tumors was determined. B2B2 chickens partially tolerant to viable or lysed white blood cells (WBC) or viable red blood cells (RBC) from B5B5 chickens had a significantly higher incidence of tumor progression than untreated, PBS-treated, or B2B2 chickens inoculated with WBC from other B2B2 chickens. The criteria for tolerance were absence of antibody titer to the cell type inoculated and acceptance of allografts from B5B5 donors by B2B2 chickens. Graft-vs-host reactions occurred only in B2B2 chickens inoculated with viable WBC from B5B5 chickens. It appears that B2B2 chickens partially tolerant to B5 antigens failed to mount a successful immune response to RSV-induced tumors partly because of a B5 MHC antigen(s) cross-reacted with a tumor associated antigen(s) thereby severely limiting B2B2 host recognition of the tumor as foreign. Since WBC and RBC cell-surface antigens appear to contribute similarly to the effect, the B-F- region of the MHC may be involved.
D000818:Animals; D000906:Antibodies; D001358:Avian Sarcoma Viruses / Q000276:immunology*; D002472:Cell Transformation, Viral; D002645:Chickens; D006087:Graft vs Host Reaction; D007108:Immune Tolerance; D007519:Isoantigens / Q000276:immunology; D008285:Major Histocompatibility Complex; D016038:Skin Transplantation
D000906:Antibodies; D007519:Isoantigens