Effect of two kinds of pectin and guar gum on 1,2-dimethylhydrazine initiation of colon tumors and on fecal beta-glucuronidase activity in the rat.
The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of control group fed a fiber-free diet. Both kinds of pectin increased the multiplicity of color tumors, whereas guar gum did not significantly influence carcinogenesis. Bacterial beta-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D001835:Body Weight; D002482:Cellulose / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004043:Dietary Fiber / Q000494:pharmacology*; D004127:Dimethylhydrazines / Q000633:toxicity*; D005243:Feces / Q000032:analysis / Q000201:enzymology*; D005966:Glucuronidase / Q000378:metabolism*; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D010368:Pectins / Q000494:pharmacology*; D051381:Rats
D004043:Dietary Fiber; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D010368:Pectins; D002482:Cellulose; D005966:Glucuronidase