title: Pentobarbitone slows the dissociation of GABA from rat brain synaptosomal binding sites.
abstract: The dissociation of GABA from rat brain synaptosomal binding sites is characterized by an initial rapid phase followed by a slower phase which may represent dissociation of GABA from high affinity binding sites. The dissociation rate constant (K-1) calculated from this secondary phase is significantly reduced by pentobarbitone (100 micrometers). This result supports the finding that barbiturates increase the affinity of GABA for a high affinity binding site.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D011963:Receptors, GABA-A; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital