title: Spenolimycin, a new spectinomycin-type antibiotic. III. Biological properties.
abstract: Spenolimycin is a new spectinomycin-type antibiotic isolated from Streptomyces gilvospiralis sp. nov. In vitro, it was active against a wide variety of aerobic Gram-positive and Gram-negative bacteria and Neisseria gonorrhoeae. It was two to four-fold more active against N. gonorrhoeae than spectinomycin. Spenolimycin was effective in the standard mouse protection test against Escherichia coli, Klebsiella pneumoniae and Streptococcus pneumoniae.
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D000198:Spectinomycin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000198:Spectinomycin; C044528:spenolimycin