Transfer of tritium-labeled vitamin D3 and 25-hydroxyvitamin D3 in ovine placenta.
Placental transmission of IV-administered label from vitamin D3 and 25-hydroxycholecalciferol was studied in gestating ewes. Radioactivity concentrations were higher in the tissues of ewes dosed with vitamin D3 than in those dosed with 25-hydroxycholecalciferol. Concentrations were higher in maternal tissues than in fetal tissues. The highest radioactivity concentrations were found in kidneys, followed by concentrations in the adrenal glands.
D000818:Animals; D002762:Cholecalciferol / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D006887:Hydroxycholecalciferols / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012756:Sheep / Q000378:metabolism* / Q000502:physiology
D006887:Hydroxycholecalciferols; D002762:Cholecalciferol