Histopathology of carcinomas of the liver in mice fed perthane.
B6C3F1 female mice fed an average dose of 3,000 ppm of perthane for 2 years developed a highly significant incidence of hepatocellular carcinomas of the liver. Male mice fed 2,500 ppm perthane had a slight increase of carcinoma of the liver. Some of the carcinomas were well-differentiated; however, most were poorly differentiated or undifferentiated. Perthane-treated mice also had well and poorly differentiated cholangiocarcinomas and carcinosarcomas, neoplasms not seen in control mice.
D002759:Adenoma, Bile Duct / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003632:Dichlorodiphenyldichloroethane / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D051379:Mice; D012737:Sex Factors
C005292:perthane; D003632:Dichlorodiphenyldichloroethane