title: Presence of allograft-rejection resistance in simian virus 40-transformed hamster cells and its possible role in tumor development.
abstract: LSH Syrian hamster cells transformed in vitro by simian virus 40, which is oncogenic for hamsters, are resistant to rejection by adult allogeneic CB hamsters. In contrast, simian virus 40-transformed cells from other species are usually not oncogenic in immunocompetent autologous or isologous hosts. The ability of simian virus 40 to convey resistance to an allograft-type host response to transformed hamster cells may be important in determining the tumor-inducing capacity of these cells and could, in part, explain the species-specific oncogenicity of this virus.
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D006224:Cricetinae / Q000276:immunology*; D006084:Graft Rejection; D007519:Isoantigens; D008647:Mesocricetus / Q000276:immunology*; D009368:Neoplasm Transplantation; D013539:Simian virus 40 / Q000276:immunology*; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000276:immunology*
chemical_list: D007519:Isoantigens