The effect of conditions influencing endogenous prostaglandins on the activity of delta'-tetrahydrocannabinol in mice.
1 The cataleptic effect of delta'-tetrahydrocannabinol (THC) depends upon the availability of the precursors of prostaglandins and the response is reduced in mice maintained on a diet deficient in arachidonic acid (AA) and restored by exogenous AA given intraperitoneally, or by feeding a normal diet. 2 In yeast-induced fever, which is accompanied by an increase in the synthesis of prostaglandins, THC shows an enhanced cataleptic effect. 3 Exposure to cold which results in depletion of prostaglandins reduces the effect of THC.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced; D003080:Cold Temperature; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology; D013759:Dronabinol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D051379:Mice; D009181:Mycoses / Q000503:physiopathology; D011453:Prostaglandins / Q000502:physiology*
D004041:Dietary Fats; D011453:Prostaglandins; D013759:Dronabinol