Inhibition cAMP-phosphodiesterase in the rat heart by pentoxifylline--a new xanthine derivative.
Pentoxifylline, a new xanthine derivative with properties favorably affecting the rheological profile of blood, was administered to male rats weighing 200--300 g in doses of 5, 10, 15, and 20 mg/kg of body weight for five days. Up to 27% of the intracellular cAMP-phosphodiesterase (cAMP-PDE) of the myocardium was dose-dependently inhibited. A significant increase in the protein content of the heart (wet weight) was also recorded, but was unrelated to the dose of pentoxifylline and without evidence of cardiac hypertrophy.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000033:anatomy & histology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009929:Organ Size; D010431:Pentoxifylline / Q000494:pharmacology*; D011506:Proteins; D051381:Rats; D013805:Theobromine / Q000031:analogs & derivatives*; D014966:Xanthenes
D011506:Proteins; D014966:Xanthenes; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D007545:Isoproterenol; D013805:Theobromine; D010431:Pentoxifylline