Chronic delta 9-tetrahydrocannabinol administration and schedule-induced aggression.
The effects of 0.5 mg/kg and 1.0 mg/kg of delta 9-tetrahydrocannabinol (delta 9-THC) on key-pecking maintained by a response-initiated fixed interval (FI) schedule of food presentation and schedule-induced aggression in the pigeon were studied. Initially, following the administration of delta 9-THC both the rate of key-pecking and attack responding were markedly reduced. Over sessions, tolerance developed to the suppressant effect on key-pecking, with the rate returning to the predrug level. The suppressing effect of delta 9-THC on the rate of attack remained at or near zero throughout the series of delta 9-THC injections.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D010856:Columbidae; D003216:Conditioning, Operant / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology*; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D012055:Reinforcement Schedule; D013997:Time Factors
D013759:Dronabinol