Heterogeneity of beta-thalassemia in Azerbaidzhan.
Globin chain synthesis, RNA and DNA of beta-thalassemic patients from Azerbaidzhan were analyzed. A beta-mRNA deficiency was found in beta +-thalassemic reticulocytes. In one case of beta +-thalassemia, it was possible to study nuclear and cytoplasmic RNA from spleen erythroid cells. The alpha/beta mRNAs sequence ratio was 5 in the nuclear and cytoplasmic RNAs. In patients with beta o-thalassemia a different level of beta-globin mRNA was demonstrated. Gene mapping analysis indicated that the general organization of the beta-globin gene was normal in the investigated cases of beta-thalassemia.
D001382:Azerbaijan; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D005914:Globins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis; D013789:Thalassemia / Q000235:genetics*
D012333:RNA, Messenger; D005914:Globins; D004247:DNA