Determination of the partition coefficient and acid dissociation constants of iodochlorhydroxyquin by an improved partition method.
A simple and precise method for determining partition coefficients was developed utilizing a disposable injector. The method was used to determine the partition ratio of iodochlorhydroxyquin between n-decane and phosphate-buffered saline, pH 7.4. The partition ratio was found to be 1750 with a coefficient of variation of 3%. Moreover, it was found that iodochlorhydroxyquin did not associate in n-decane at a concentration less than 1 X 10(-3) M. The acid dissociation constants and the partition coefficient of the undissociated species were determined. These values corresponded well with the values obtained from spectrophotometric methods.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007464:Clioquinol / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D006912:Hydroxyquinolines / Q000032:analysis*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013997:Time Factors
D006912:Hydroxyquinolines; D007464:Clioquinol