Chemotherapeutic value of 2-deoxy-D-glucose in infectious bovine rhinotracheitis viral infection in calves.
Daily injection of 2-deoxy-D-glucose (2-dG) had no protective effect against respiratory tract infection in calves caused by infectious bovine rhinotracheitis virus. It also did not reduce the severity of this infection. Ocular instillation of the drug, however, markedly reduced the severity of viral-induced conjunctivitis and keratoconjunctivitis. The drug was effective when given at the time of ocular infection or after clinical conjunctivitis developed.
D000818:Animals; D002417:Cattle; D003837:Deoxy Sugars / Q000627:therapeutic use*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000627:therapeutic use*; D007242:Herpesvirus 1, Bovine / Q000302:isolation & purification; D007241:Infectious Bovine Rhinotracheitis / Q000188:drug therapy* / Q000382:microbiology; D007267:Injections; D007275:Injections, Intravenous; D007637:Keratoconjunctivitis / Q000188:drug therapy / Q000662:veterinary; D008297:Male; D009666:Nose / Q000382:microbiology; D009883:Ophthalmic Solutions
D003837:Deoxy Sugars; D009883:Ophthalmic Solutions; D003847:Deoxyglucose