Evidence for early membrane antigens in cytomegalovirus-infected cells.
Human cytomegalovirus (HCMV) induces membrane antigens (MA) which are detectable by immunofluorescent techniques as early as 24 h after infection. These antigens appear on the surface of infected cells in non-permissive human epithelioid and animal cells in addition to permissive human cells. The synthesis of the MA occurs in the presence of a DNA synthesis inhibitor, whereas RNA and protein synthesis inhibitors prevent its formation completely. These results demonstrate that the MA is a newly synthesized protein coded by an early function of the viral genome.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D002460:Cell Line; D003561:Cytarabine / Q000494:pharmacology; D003587:Cytomegalovirus / Q000254:growth & development / Q000276:immunology*; D003609:Dactinomycin / Q000494:pharmacology; D006801:Humans; D011691:Puromycin / Q000494:pharmacology; D013997:Time Factors; D014764:Viral Proteins / Q000096:biosynthesis
D000954:Antigens, Surface; D000956:Antigens, Viral; D014764:Viral Proteins; D003561:Cytarabine; D003609:Dactinomycin; D011691:Puromycin