[Changes in the sodium current under the action of etmozin and lidocaine inside and outside the membrane of single rat myocardial cells].
The voltage clamp experiments were carried out on single internally perfused rat myocardial cells. The effect of ethmozine (8 x 10(-5) g/ml) and lidocain (8 x 10(-6) g/ml) on the fast maximum inward sodium current (INa) was studied. The drugs were tested inside and outside the cell. INa was inhibited insignificantly when ethmozine was added inside the cell. After 5 min of ethmozine action outside the cell INa dropped on the average to 43 +/- 6% of its initial value. Under these conditions the reactivation constrant of INa did not change significantly. Lidocain depressed INa both when added outside and inside the cell. However, when lidocain was added outside the cell a longer period was needed to depress INa. Comparison of lidocain and ethmozine action outside and inside the myocardial cell has shown that the sites of action of these antiarrhythmic drugs on the cellular membrane are different.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D002462:Cell Membrane / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D016293:Moricizine; D009025:Morpholines / Q000494:pharmacology; D009206:Myocardium / Q000166:cytology*; D010640:Phenothiazines / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*
D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D009025:Morpholines; D010640:Phenothiazines; D016293:Moricizine; D008012:Lidocaine; D012964:Sodium
Izmeneniia natrievogo toka pri deĭstvii étmozina i lidokaina s vneshneĭ i vnutrenneĭ storony membrany odinochnykh kletok miokarda krysy.