Treatment of feline leukemia and reversal of FeLV by ex vivo removal of IgG: a preliminary report.
Cats that were spontaneously infected with feline leukemia virus (FeLv) were treated with a combination of low-dose irradiation and extracorporeal immunosorption using formalin and heat-fixed S. aureus as a non-specific immunosorbent to remove plasma IgG and immune complexes. The treatment resulted in reduction of circulating lymphoblasts within two weeks and clinical improvement of three of the five animals. A reversal of the FeLV status is reported in five of five cats. Two of the five cats remain FeLV negative and completely tumor free seven and eight months post-therapy at the time of writing (July 1979). A third cat returned to an FeLV positive state but remained tumor free for 24 weeks. Another cat responded to the therapy by reduction of lymphoblasts and became FeLV negative but died of a hemorrhage during an immunosorption. The last cat's status was FeLV positive, then FeLV negative, and finally FeLV positive again. He died 20 weeks after initiation of therapy. During the treatment there was a weight gain in the three cats responding by tumor regression. The results are discussed in terms of a removal of some type of immunoinhibiting factors such as antigen-antibody complexes or suppressor molecules.
D000818:Animals; D000936:Antigen-Antibody Complex; D002415:Cats; D007074:Immunoglobulin G / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D005256:Leukemia Virus, Feline / Q000276:immunology; D007942:Leukemia, Experimental / Q000382:microbiology / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D013211:Staphylococcus aureus / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000528:radiation effects
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G