Anticonvulsant effects of caerulein, cholecystokinin octapeptide (CCK-8) and diazepam against seizures produced in mice by harman, thiosemicarbazide and isoniazid.
Caerulein, cholecystokinin octapeptide (CCK-8) and diazepam delayed the onset of seizures produced by harman and thiosemicarbazide (TSC). Caerulein had the potency of diazepam, whereas CCK-8 was less active by a factor of four. The convulsions induced by isoniazid (INH) were very resistant to both caerulein and diazepam; CCK-8 was not tested against isoniazid. Haloperidol did not influence the effect of TSC; it enhanced isoniazid-induced seizures, and antagonized the convulsant effect of harman.
D000818:Animals; D000927:Anticonvulsants; D002108:Ceruletide / Q000494:pharmacology*; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D006247:Harmine / Q000031:analogs & derivatives; D007538:Isoniazid; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D012663:Semicarbazides; D012844:Sincalide
D000927:Anticonvulsants; D012663:Semicarbazides; D006247:Harmine; C005151:thiosemicarbazide; C005010:harman; D002108:Ceruletide; D002766:Cholecystokinin; D006220:Haloperidol; D012844:Sincalide; D003975:Diazepam; D007538:Isoniazid