Distribution of steroid hormone receptors in human soft tissue sarcomas.
Sixty-six human soft-tissue sarcoma specimens were assayed for incidence and distribution of steroid hormone receptors. Liposarcomas (43%) and leiomyosarcomas (60%) had a high incidence of estrogen receptor. In contrast, sarcomas of fibrous and synovial tissue origin lacked any detectable receptor for estrogen. Malignant fibrous histiocytoma had the highest incidence of glucocorticoid (66%) and androgen (66%) receptors. The incidence of receptors for estrogen and glucocorticoid was higher in female than in male patients (62% and 38%, respectively). Sucrose density gradients demonstrated 8s-type receptors for both estrogen and glucocorticoid. Data from this study suggest that specific high-affinity cytosolic receptors for steroid hormones are present in human soft tissue sarcoma and that their distribution may depend on the histogenetic origin and the sex of patients.
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000032:analysis; D006801:Humans; D007890:Leiomyosarcoma / Q000032:analysis; D008080:Liposarcoma / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011965:Receptors, Glucocorticoid / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*; D012509:Sarcoma / Q000032:analysis*; D012737:Sex Factors; D012983:Soft Tissue Neoplasms / Q000032:analysis*
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid