Effect of retinoic acid (RA) on the Epstein-Barr virus (EBV)-inducing effect of sodium butyrate.
Sodium butyrate is a powerful inducer of the Epstein-Barr virus (EBV) cycle in the P3HR-1 cell line. Retinoic acid (RA) was found to reduce the butyrate induction of early antigen (EA) and viral capsid antigen (VCA) by 26-41%. This is similar to the previously reported effect of RA on IUDR and TPA induction, with certain quantitative differences between the systems.
D000956:Antigens, Viral / Q000032:analysis; D002087:Butyrates / Q000494:pharmacology*; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D007065:Idoxuridine / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology*; D014775:Virus Activation / Q000187:drug effects*
D000956:Antigens, Viral; D002087:Butyrates; D014212:Tretinoin; D007065:Idoxuridine