Induction of Epstein-Barr virus antigens in human lymphoblastoid P3HR-1 cells with culture fluid of Fusobacterium nucleatum.
Epstein-Barr virus-associated early antigen and viral capsid antigen were efficiently induced in human lymphoblastoid P3HR-1 cells with culture fluid of Fusobacterium nucleatum, a member of the indigenous microbial flora of the human host. This finding may suggest a new approach to assess the possible role of the "cofactor(s)" in the etiology of Epstein-Barr virus-related diseases.
D000956:Antigens, Viral / Q000032:analysis*; D002087:Butyrates / Q000494:pharmacology*; D002213:Capsid / Q000276:immunology; D003470:Culture Media; D005673:Fusobacterium / Q000502:physiology*; D004854:Herpesvirus 4, Human / Q000254:growth & development / Q000276:immunology*; D006801:Humans; D014779:Virus Replication / Q000187:drug effects
D000956:Antigens, Viral; D002087:Butyrates; D003470:Culture Media