Transposable gentamicin resistance in IncW plasmids from Hammersmith Hospital.
A transposon, Tn733, encoding the gentamicin acetyltransferase AAC(3) was found on two gentamicin R plasmids of IncW at Hammersmith Hospital. Transposon TN733 has a molecular mass of 5.8 megadaltons and gives a characteristic 2.4 megadalton fragment on digestion with EcoRI. The appearance of gentamicin resistance on a transposon will increase the chances of spread of this gene.
D003227:Conjugation, Genetic; D004247:DNA; D004251:DNA Transposable Elements; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005839:Gentamicins / Q000494:pharmacology*; D008970:Molecular Weight; D011815:R Factors
D004251:DNA Transposable Elements; D005839:Gentamicins; D004247:DNA