Analytical determination of purity of 1-piperidinocyclohexanecarbonitrile and its hydrobromide salt.
A common contaminant of illicit phencyclidine, 1-piperidinocyclohexanecarbonitrile (I), is a very weak base compared to tertiary amines such as phencyclidine, 1-(cyclohexenyl)piperidine, and piperidine. Compound I and its hydrobromide salt can be selectively detected and quantitated in the presence of synthetic contaminants by nonaqueous titration with perchloric acid in acetonitrile. This method allows direct assay of I under conditions where decomposition is not observed.
D004340:Drug Contamination; D006801:Humans; D009570:Nitriles / Q000032:analysis*; D010472:Perchlorates; D010622:Phencyclidine / Q000031:analogs & derivatives; D010623:Phencyclidine Abuse; D010880:Piperidines / Q000032:analysis*; D011199:Potentiometry
D009570:Nitriles; D010472:Perchlorates; D010880:Piperidines; C011993:1-piperidinocyclohexanecarbonitrile; D010622:Phencyclidine