title: Hyperkeratosis induced by sunlight degradation products of the major polybrominated biphenyl in Firemaster.
abstract: Sunlight photodegradation of 2,2', 4,4', 5,5' -hexabromobiphenyl, the major component of Firemaster, gave a mixture that produces severe hyperkeratosis of the rabbit ear. This component in its pure state does not cause hyperkeratosis. One or more of the four major photolysis products must be responsible for this activity. A similar photodegradation pattern was observed for 2,2', 3,4,4', 5,5' -heptabromobiphenyl, the second largest component of Firemaster.
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000528:radiation effects; D002617:Chemical Industry; D004195:Disease Models, Animal; D004781:Environmental Exposure; D007642:Keratosis / Q000139:chemically induced*; D008824:Michigan; D010777:Photochemistry; D011075:Polybrominated Biphenyls / Q000528:radiation effects; D011817:Rabbits; D013472:Sunlight
chemical_list: D001713:Biphenyl Compounds; D011075:Polybrominated Biphenyls