Antibiotic inhibition of protease production by Pseudomonas aeruginosa.
The effects of tetracycline, chloramphenicol and polymyxin B on growth and protease production by Pseudomonas aeruginosa were studied. Tetracycline inhibited protease production at concentrations much lower than those required to cause growth inhibition; the effect was not due to inhibition of protease activity by the antibiotic. In contrast, chloramphenicol and polymyxin B inhibted protease production in direct proportion to the inhibition of growth. Lysozyme-release experiments with washed tetracycline-treated cells indicated that the protease did not accumulate intracellularly. The protease-inhibiting effect of tetracycline might have therapeutic significance if it were found to occur in vivo.
D002701:Chloramphenicol / Q000494:pharmacology*; D009113:Muramidase / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000096:biosynthesis*; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D013752:Tetracycline / Q000494:pharmacology*
D011113:Polymyxins; D002701:Chloramphenicol; D009113:Muramidase; D010447:Peptide Hydrolases; D013752:Tetracycline; D011112:Polymyxin B