Effects of an ACTH short chain neuropeptide in man.
The authors studied the effect of an ACTH 4-9 analogue (the shortest behaviorally active fragment of the ACTH neuropeptide) on mood in normal aging volunteers. These mood changes, described as a sense of well-being, energy, and drive, are consistent with an arousal-stimulant mechanism of action of the compound. No effect of the compound was found on attention or memory. Because of its apparent safety and the lack of adverse effects, the authors suggest that this short chain neuropeptide be further explored in older individuals for its mood-elevating and potential antidepressant properties.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology* / Q000627:therapeutic use; D000339:Affect / Q000187:drug effects*; D000368:Aged; D000928:Antidepressive Agents; D001143:Arousal / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy*; D008875:Middle Aged; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors
D000928:Antidepressive Agents; D010446:Peptide Fragments; C028024:ACTH (4-9); D000324:Adrenocorticotropic Hormone