title: Activation and lateralization of sensorimotor field for perioral biting reflex by intranigral GABA agonist and by systemic apomorphine in the rat.
abstract: In Experiment 1 unilateral injection of the GABA agonist, muscimol (20 ng in 0.1 microliter saline) into the substantia nigra (SN) of rats elicited contraversive turning and a correlated transient asymmetry in responsiveness to tactile stimulation of the mouth area. On the side of the face contralateral to the injected SN they responded stronger than on the ipsilateral side, and, furthermore, they responded to tactile stimulation with a withdrawal of the lip, followed by a vigorous biting of the probe. In Experiment 2, systemic injection of apomorphine also sensitized the perioral biting response to tactile stimulation. Unilateral injection into the SN of 8 micrograms 6-OHDA blocked this response to stimulation of the side of the face ipsilateral to the lesion. The experiments demonstrate: (1) pharmacological control of sensory-motor neglect, the asymmetry being determined by the direction of turning; and (2) a possible neuropharmacological basis of the perioral biting reflex, which may be related to certain types of aggressive behaviors.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004292:Dominance, Cerebral / Q000187:drug effects*; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D008409:Mastication; D008465:Mechanoreceptors / Q000187:drug effects; D009055:Mouth / Q000294:innervation; D009118:Muscimol / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D011963:Receptors, GABA-A; D012018:Reflex / Q000187:drug effects*; D013003:Somatosensory Cortex / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D013378:Substantia Nigra / Q000187:drug effects*; D014110:Touch / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D001058:Apomorphine; D006892:Hydroxydopamines; D009118:Muscimol; D010852:Picrotoxin; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid