[Effect of administration of ampiox and guanosine triphosphate on the concentration of cyclic nucleotides in the muscle tissue of a zone of inflammation].
Experiments on rabbits with infiltrates induced by intracutaneous injection of staphylococcal culture were made to examine the content of cyclic nucleotides in the adjacent muscle tissue under the effect of administering ampiox alone or combined with guanosine triphosphate (GTP). Combined injection of ampiox and GTP to the infected animals produced a considerable elevation in the content of cAMP (more than 2 1/2-fold) and in the cAMP/cGMP ratio along with a beneficial therapeutic effect. The possible mechanisms of action of the agents administered are discussed.
D000667:Ampicillin / Q000008:administration & dosage*; D000818:Animals; D002682:Chinchilla; D000242:Cyclic AMP / Q000032:analysis; D006152:Cyclic GMP / Q000032:analysis; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006160:Guanosine Triphosphate / Q000008:administration & dosage*; D009132:Muscles / Q000032:analysis*; D009712:Nucleotides, Cyclic / Q000032:analysis; D010068:Oxacillin / Q000008:administration & dosage*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000378:metabolism
D004338:Drug Combinations; D009712:Nucleotides, Cyclic; D000667:Ampicillin; C000307:broadcillin; D006160:Guanosine Triphosphate; D000242:Cyclic AMP; D006152:Cyclic GMP; D010068:Oxacillin
Soderzhanie tsiklicheskikh nukleotidov v myshechnoĭ tkani zony vospaleniia na fone vvedeniia ampioksa i guanozintrifosfata.