[Modification of glucose resorption by bulk materials].
40 test persons were randomized for testing the influence on the glucose resorption by ballast substances. The four groups consisted of 10 persons with healthy metabolism, 10 diabetics with diet, 10 with maninil 5 and 10 with B-insulin. The oral glucose tolerance test with 100 g glucose was used. The examination time after application of the test meal was 120 minutes. As ballast substances the hemicelluloses supercol (galactomannan) and manucol (sodium alginate) were tested. For comparison an examination with only 100 g glucose (experiment A) and one with a placebo substance (experiment D) were performed. Of supercol (experiment B), mannucol (experiment C) and of the placebo substance 20 g were added to the sugar solution. Using supercol we could get unequivocally lower mean blood sugar curves in non-diabetics and in all groups of diabetics compared with the examination without addition of substance and with addition of placebo. When manucol was used, a decrease of the mean blood sugar curves could be observed, however, not proved. Thus the swelling substance supercol leads to a retardation of the glucose resorption.
D000464:Alginates / Q000378:metabolism; D002482:Cellulose / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000378:metabolism; D004043:Dietary Fiber / Q000494:pharmacology*; D005503:Food Additives / Q000378:metabolism* / Q000494:pharmacology; D005685:Galactans / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects; D008351:Mannans / Q000378:metabolism; D053149:Plant Gums; D011134:Polysaccharides / Q000378:metabolism
D000464:Alginates; D004043:Dietary Fiber; D005503:Food Additives; D005685:Galactans; D007328:Insulin; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; D002482:Cellulose; D005947:Glucose; D005905:Glyburide; C017471:locust bean gum
Beeinflussung der Glukoseresorption durch Ballaststoffe.