Effects of inhibition and stimulation of Na+-K+ active transport on the resting membrane input conductance of the guinea-pig ventricle.
The effects of inhibition by ouabain and stimulation by high frequency drive of the sarcolemmal Na+-K+ active transport system on the resting input conductance (gi) of guinea-pig ventricular muscles were determined. Although both pump inhibition and stimulation were associated with changes in electrophysiological properties of the muscles, neither had a significant effect on gi.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D016276:Ventricular Function
D010042:Ouabain; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium