title: [Diffusion of fosfomycin into the cerebrospinal fluid in purulent meningitis].
abstract: Cerebrospinal fluid levels of fosfomycin were measured in 10 patients with bacterial meningitis. Fosfomycin 200 mg/kg/day was administered in three 4-hour intravenous infusions. The antibiotic was associated with amoxicillin in 9 patients and with cefotaxime in one. Cerebrospinal fluid was obtained on the 2nd and 5th days of treatment, 2 hours after the end of the infusion. The mean CSF fosfomycin levels were 31 mg/l on the 2nd day and 37.2 mg/l on the 5th day. These levels were higher than the MIC 90 for most bacteria encountered in meningitis. Fosfomycin could be used to treat some cases of bacterial meningitis, but always in association with another antibiotic.
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000134:cerebrospinal fluid*; D005260:Female; D005578:Fosfomycin / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin
vernacular_title: Diffusion de la fosfomycine dans le liquide céphalo-rachidien au cours des méningites purulentes.