Review: prostaglandins and cancer.
This paper reviews work on the role of prostaglandins in cancer. A substantial body of evidence demonstrates elevated amounts of E series of prostaglandins in human and experimental tumors. Blockade of prostaglandin synthesis in vitro or in vivo results in inhibition of tumor growth. Involvement of prostaglandins is implicated in the actions of tumor promoters like phorbol and polycyclic aromatic hydrocarbon carcinogens. Symptoms like hypercalcemia, osteolysis and tumor metastasis are discussed where disordered synthesis and/or action of prostaglandins and related substances might have a role in the altered metabolism associated with neoplasia.
D000818:Animals; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000139:chemically induced / Q000503:physiopathology*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011453:Prostaglandins / Q000494:pharmacology / Q000502:physiology*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D000242:Cyclic AMP