[NADPH2 and organic hydroperoxide-dependent oxidation of adrenaline to adrenochromes in liver and brain microsomes].
It was shown that oxidation of adrenaline to adrenochrome in microsomal membranes of the brain and liver in the presence of NADP . H2 or NAD . H2 is mainly accounted for by the formation of a superoxide anion radical. The formation of adrenochrome from adrenalin was found to depend on organic hydroperoxides (natural and synthetic). The organic hydroperoxide-dependent oxidation of adrenochrome involves singlet oxygen. In microsomal fractions of the liver the organic peroxide-dependent oxidation of adrenalin was catalyzed by cytochrome P-450.
D000323:Adrenochrome / Q000096:biosynthesis*; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004579:Electron Transport; D004837:Epinephrine / Q000378:metabolism*; D005609:Free Radicals; D008054:Lipid Peroxides / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D010545:Peroxides / Q000494:pharmacology; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D001559:Benzhydryl Compounds; D005609:Free Radicals; D008054:Lipid Peroxides; D010545:Peroxides; D010714:Phosphatidylethanolamines; C027850:phosphatidylethanolamine hydroperoxide; D013481:Superoxides; C027851:diphenylethane hydroperoxide; D009249:NADP; D000323:Adrenochrome; D003577:Cytochrome P-450 Enzyme System; D013482:Superoxide Dismutase; D004837:Epinephrine
Zavisimoe ot NADFH2 i organicheskikh gidroperekiseĭ okislenie adrenalina v adrenokhrom v mikrosomakh pecheni i mozga.