title: The tetracycline-resistance transposon Tn10 inhibits translocation of Tn10.
abstract: Using a set of overlapping deletion mutants in the tetracycline-resistance transposon Tn10, it has been established that certain regions of the Tn10 genome exert a powerful inhibition on translocation of an intact Tn10 element into the bacterial genome. Such inhibition is strongly temperature dependent: at 37 degrees C translocation is inhibited by at least a factor of 100; no inhibition of translocation is detected at 30 degrees C.
mesh_terms: D002872:Chromosome Deletion; D002876:Chromosomes, Bacterial / Q000378:metabolism; D004251:DNA Transposable Elements; D004352:Drug Resistance, Microbial; D009154:Mutation; D011995:Recombination, Genetic; D012486:Salmonella typhimurium / Q000235:genetics*; D013696:Temperature; D013752:Tetracycline / Q000378:metabolism
chemical_list: D004251:DNA Transposable Elements; D013752:Tetracycline