Haemoglobin K Woolwich: a study of the family of a homozygote.
A family is described in which the proband is homozygous and several relatives are heterozygous for Hb K Woolwich (beta 130 [H10] Lys leads to Gln). These people are clinically and haematologically normal. The relationship between the presence of Hb K Woolwich and beta +-thalassaemia is discussed. The distribution of Hb K Woolwich in West Africa is discussed and it is seen to be closely associated with the Akan group.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D007560:Cote d'Ivoire; D005260:Female; D005787:Gene Frequency; D005914:Globins / Q000032:analysis; D006453:Hemoglobinopathies / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D013789:Thalassemia / Q000235:genetics
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D005914:Globins