Regional cerebral Na+K+ ATPase activity following octanoate administration.
Sodium octanoate in an 0.2 M solution was administered to rabbits by continuous slow IV infusion over 4 hr. Controls were given identical infusions of normal saline. The animals were then sacrificed, brains were removed, and specific areas were isolated and assayed for Na+K+ ATPase activity. Significant inhibition of regional Na+K+ ATPase activity was detected in cortex, thalamus, hypothalamus, pons, and medulla of rabbits given octanoate when compared to controls.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002210:Caprylates / Q000494:pharmacology*; D003864:Depression, Chemical; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D002210:Caprylates; D000254:Sodium-Potassium-Exchanging ATPase