title: Immune profile of infectious bursal disease: I. Effect of infectious bursal disease virus on peripheral blood T and B lymphocytes of chickens.
abstract: A comparison was made of absolute numbers of peripheral blood B and T lymphocytes, as defined by the anti-bursal and anti-thymus sera, in chickens infected with infectious bursal disease virus at one day and 3 weeks of age by age-matched controls. Birds were evaluated sequentially at weekly intervals for a period of 8 weeks postinfection. The severity of depressions of B-lymphocyte numbers was found to be age-dependent: the birds infected at one day of age showed a more severe depletion than those infected at 3 weeks of age. The T-lymphocyte numbers were less markedly affected in infected chickens of either age group.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002645:Chickens / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007243:Infectious bursal disease virus / Q000276:immunology*; D007958:Leukocyte Count; D011201:Poultry Diseases / Q000276:immunology*; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology / Q000662:veterinary*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000961:Antilymphocyte Serum