title: [25-hydroxycholecalciferol and 24,25-dihydroxycholecalciferol content on rat tissues in vitamin D poisoning].
abstract: As vitamin D3 dose increases, the level of 25-hydroxycholecalciferol in the blood plasma, liver, kidneys, small intestine, bones and muscles of rats rises. The maximum concentration and maximum content of 25-hydroxycholecalciferol with reference to the entire tissue growing with vitamin D3 dose increase are characteristic for the osteal tissue. The synthesis of excess quantities of 25-hydroxycholecalciferol is followed by formation of a metabolite that is similar to 24,25-dioxycholecalciferol from the standpoint of chromatographic mobility. The metabolite is accumulated in the kidneys, intestine, blood plasma and to a less measure in the osteal tissue. No metabolite could be detected in the liver or muscles.
mesh_terms: D000818:Animals; D002762:Cholecalciferol / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006887:Hydroxycholecalciferols / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014807:Vitamin D / Q000506:poisoning*
chemical_list: D006887:Hydroxycholecalciferols; D014807:Vitamin D; D002762:Cholecalciferol
vernacular_title: Soderzhanie 25-oksikholekal'tsiferola i 24,25-dioksikholekal'tsoferola v tkaniakh krys pri D-vitaminnoĭ intoksikatsii.