title: Estrogen receptors in male breast cancer: clinical and pathologic correlations.
abstract: Breast cancer tissue from 12 male patients was evaluated for the presence of estrogen receptors (ER), and at least 10 of 12 were found to be high in ER (ER+). A combination of previously published cases and our own experience indicates that 80% of patients (37/47) have ER+ tumors. This incidence of ER positivity in men is greater than that in women with breast cancer. Clinical responses to hormonal therapy have been observed in the ER+ patients but not in one ER--patient. Measurement of ER may be clinically important in men with breast cancer.
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000032:analysis* / Q000473:pathology; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000032:analysis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*; D012737:Sex Factors
chemical_list: D011960:Receptors, Estrogen