Changes in the peripheral blood leucocyte populations following an injection of corticotrophin in the immature chicken.
Three-week-old chickens were given an injection of corticotrophin (ACTH) (30 iu/kg) and changes in the plasma concentration of corticosterone and the numbers of peripheral blood leucocytes (PBL) were determined over a 32 hour period. Plasma corticosterone concentration increased to a peak after two hours but was within the normal range after eight hours. The PBL response was biphasic, a leucopenia after one hour and a marked leucocytosis between four and 12 hours after injection of ACTH. The leucopenia, caused by a reduction in the number of circulating lymphocytes, was significant at one and two hours; the leucocytosis was caused by a large increase in the number of polymorphonuclear cells. There were no consistent changes in the numbers of basophils, eosinophils or large mononuclear cells.
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002645:Chickens / Q000097:blood*; D003345:Corticosterone / Q000097:blood; D005260:Female; D007275:Injections, Intravenous; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D008297:Male
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone