Replicating, differentiated macrophages can serve as in vitro targets for transformation by avian myeloblastosis virus.
Pure cultures of chicken macrophages were characterized functionally and transformed by avian myeloblastosis virus. Transformed cells exhibited an altered function. The efficiency of transformation was limited by the mitotic activity of the macrophages.
D000818:Animals; D001354:Avian Leukosis Virus / Q000378:metabolism*; D009189:Avian Myeloblastosis Virus / Q000378:metabolism*; D002455:Cell Division; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002645:Chickens; D008264:Macrophages / Q000254:growth & development*; D013997:Time Factors