title: Effects of Pexid on liver cell cultures. Ultrastructural and histoenzymological studies.
abstract: The effects of different doses of Pexid on cultured liver cells have been studied by ultrastructural and histoenzymological techniques. Two types of abnormal lysosomal inclusions were seen: clear matrix inclusions with either homogeneous or tiny lamellar structures, and dark matrix inclusions with clear vacuoles and either random or myelin-like lamellar structures. These patterns correspond to storage of triglycerides, phospholipids and gangliosides, either singly or together.
mesh_terms: D002478:Cells, Cultured; D005732:Gangliosides / Q000032:analysis; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008854:Microscopy, Electron; D010480:Perhexiline / Q000031:analogs & derivatives / Q000633:toxicity*; D010880:Piperidines / Q000633:toxicity*
chemical_list: D005732:Gangliosides; D010880:Piperidines; D006003:Glycogen; C023470:perhexiline maleate; D010480:Perhexiline