Chloramphenicol toxicity in radiation disease.
The effect of chloramphenicol given in high therapeutic doses, in the course of postirradiation syndrome in irradiated mice of C57Bl/10 strain, is reported. Chloramphenicol treatment increased postirradiation mortality of animals and intensified suppression of the proliferating and differentiating processes in hemopoietic organs of the irradiated animals. The results support the assumption that postirradiation depression of hemopoiesis is a contraindication to the therapeutic employment of this antibiotic.
D000818:Animals; D001345:Autoradiography; D001853:Bone Marrow / Q000187:drug effects; D002701:Chloramphenicol / Q000627:therapeutic use / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011832:Radiation Injuries / Q000188:drug therapy*; D013154:Spleen / Q000187:drug effects
D002701:Chloramphenicol