Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor.
Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.
D000818:Animals; D001667:Binding, Competitive; D001792:Blood Platelets / Q000502:physiology*; D002460:Cell Line; D004705:Endocytosis; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D006133:Growth Substances / Q000494:pharmacology*; D051379:Mice; D010455:Peptides / Q000378:metabolism* / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism
D006133:Growth Substances; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D066246:ErbB Receptors