title: Hereditary spastic paraplegia with neurogenic bladder disturbances and syndactylia.
abstract: The present paper reports a family settled in the northern part of Norway, with a hereditary neurological disorder consisting clinically of spastic paraplegia associated with neurogenic bladder disturbances and syndactylia. Nine out of 22 members in three generations exhibit these clinical features. The bladder disturbances, being incomplete supranuclear bladder paresis (uninhibited neurogenic bladder), were the main complaint and occurred at an early stage of the disease. The family probably represents an unusual form of hereditary spastic paraplegia (HSP). The mode of inheritance is considered to be autosomal dominant.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity; D010264:Paraplegia / Q000235:genetics*; D010375:Pedigree; D013576:Syndactyly / Q000235:genetics*; D001750:Urinary Bladder, Neurogenic / Q000235:genetics*