[Paramagnetic diethyleneimides of urethane phosphoric acids as antitumor agents].
Under study were paramagnetic diethylene imides of urethan phosphoric acids containing three type groups showing carcinostatic activity. There was found small toxicity and a wide spectrum of the antitumor effect of the compounds, also the correlation between the chemical structure and carcinostatic effect was investigated. The nitroxyl radical was shown to participate in the antitumor effect manifestation.
D000818:Animals; D000970:Antineoplastic Agents; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004578:Electron Spin Resonance Spectroscopy; D007094:Imides / Q000627:therapeutic use*; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009943:Organophosphorus Compounds / Q000627:therapeutic use; D010756:Phosphoric Acids / Q000627:therapeutic use*; D051381:Rats; D012510:Sarcoma 180 / Q000188:drug therapy; D013329:Structure-Activity Relationship; D014520:Urethane / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D007094:Imides; D009943:Organophosphorus Compounds; D010756:Phosphoric Acids; D014520:Urethane
Paramagnitnye diétilenimidy uretanfosfornykh kislot kak protivoopukholevye agenty.