Effects of malnutrition and quipazine on rat cerebral cortex ATPase activity during development.
Previous results suggested a possible association between brain serotonin (5-HT) and Na+-K+-ATPase, in vivo. We extended the study to the developmental response of this enzyme to early 5-HT changes induced by early malnutrition and by a serotonin agonist. Agonist treatment produced a response of the enzyme activity at early stages of development in normal and malnourished brains. The induction of 5-HT changes through malnutrition could be playing an important role in the development and maturation of Na+-K+-ATPase activity, and brain 5-HT receptors could possibly be involved in such a response.
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D005260:Female; D005865:Gestational Age; D008297:Male; D009748:Nutrition Disorders / Q000378:metabolism*; D010922:Placenta Diseases / Q000378:metabolism*; D011247:Pregnancy; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D011804:Quinolines; D012701:Serotonin; D011814:Quipazine; D000254:Sodium-Potassium-Exchanging ATPase