[Duration of efficiency of pertussis immunoglobulin in the passive protection tests in mice (author's transl)].
The prophylactical effect of human anti-Pertussis immunoglobulin was shown in a passive protection test in mice over a time of 9 days, which is more than three times the half live time. In the agglutination test one could find a half life time of 64.7 hours; in the neutralisation test, which is the only valuable for the clinical effect, we could find an average value of half life time of 51.6 hours. We found a nearly parallel decrease in both titers. In the view of our results we discussed former clinical trials and the prospects for a future use of anti-Pertussis immunoglobulins in prophylaxis and therapy; in both fields only those preparations should be used, which are tested for clinical efficiency in a neutralisation test.
D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology*; D006207:Half-Life; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000276:immunology*; D051379:Mice; D009500:Neutralization Tests; D014917:Whooping Cough / Q000276:immunology*
D000907:Antibodies, Bacterial; D007136:Immunoglobulins
Wirkungsdauer von Pertussis-Immunoglobulin vom Menschen im passiven Mäuseschutzversuch.