title: Early events following the binding of epidermal growth factor to surface receptors on ovarian granulosa cells.
abstract: Receptors for epidermal growth factor (EGF) have been localized on the surface of ovarian granulosa cells using a colloidal gold avidin complex in conjunction with biotinylated EGF. On cells incubated at low temperature the receptors are predominantly monodisperse and have a random distribution. When cells are warmed to 37 degrees C the receptors aggregate into clusters.
mesh_terms: D000818:Animals; D001710:Biotin / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010053:Ovary / Q000166:cytology*; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D001710:Biotin; D066246:ErbB Receptors