Hydrolysis of gangliosides in micellar and liposomal dispersion by bacterial neuraminidases.
Aqueous dispersions of pure gangliosides contain micelles of these compounds. In this dispersion state, the rates of hydrolysis of the neuraminyl residues by bacterial neuraminidases are slowest. Incorporation of gangliosides into mixed dispersion with other lipids or into mixed micelles with bile salts considerably increases the reaction rates. The greatest reaction rates are obtained when di- or trisialogangliosides are incorporated into unilamellar vesicles of lecithin or sphingomyelin.
D003016:Clostridium perfringens / Q000201:enzymology*; D003102:Colloids; D005677:G(M1) Ganglioside; D005732:Gangliosides; D007700:Kinetics; D008081:Liposomes; D008823:Micelles; D009439:Neuraminidase / Q000378:metabolism*; D010713:Phosphatidylcholines; D013379:Substrate Specificity; D013656:Taurocholic Acid / Q000494:pharmacology; D013657:Taurodeoxycholic Acid / Q000494:pharmacology; D014734:Vibrio cholerae / Q000201:enzymology*
D003102:Colloids; D005732:Gangliosides; D008081:Liposomes; D008823:Micelles; D010713:Phosphatidylcholines; D005677:G(M1) Ganglioside; D013657:Taurodeoxycholic Acid; D013656:Taurocholic Acid; D009439:Neuraminidase