title: Plasma aldosterone response to acute stimulation in panhypopituitarism.
abstract: The influence of acute stimulation by ACTH, upright posture and angiotensin II on plasma aldosterone levels was assessed in human panhypopituitarism. While stimulation by ACTH in hypopituitary patients induced a plasma aldosterone increase similar to that observed in healthy controls, stimulation by upright posture or by infusion of angiotensin II resulted in a lower plasma aldosterone response than in controls in most of the patients. These results suggest that the presence of an anterior pituitary hormone, most likely ACTH, directly or indirectly exerts a permissive action on aldosterone secretion in man.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D000450:Aldosterone / Q000097:blood* / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D011187:Posture
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone