Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage.
Analogs of adenosine 3',5'-monophosphate (cyclic AMP) inhibit the growth of cultured cell lines. The effects of 8-bromo- and N6-butyryl-substituted analogs of cyclic and noncyclic AMP on six cell lines were examined and were equally inhibitory. Variant cell lines with altered cyclic AMP-dependent protein kinase were more resistant to both cyclic and noncyclic nucleotides. We conclude that growth inhibition by analogs of cyclic AMP (i) does not require a 3',5' phosphodiester bond and (ii) may be mediated by a pathway involving endogenous cyclic AMP.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D006224:Cricetinae; D000242:Cyclic AMP / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D006131:Growth Inhibitors / Q000494:pharmacology*; D051379:Mice; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D013329:Structure-Activity Relationship
D006131:Growth Inhibitors; D010726:Phosphodiesterase Inhibitors; D004247:DNA; D000242:Cyclic AMP