[Ionic currents of neuroblastoma clone N18 A-1 cultured cells under potassium fluoride and phosphate intracellular dialysis].
Ionic currents of cells of neuroblastoma clone N18 A-1 was studied under conditions when the internal medium was placed for artificial fluoride or phosphate solutions. The specific membrane leakage resistance was measured to be 8.1 +/- 2.6 kOhm.cm2 and 1.3 +/- 0.3 Kohm.cm2, respectively. The presence of usual sodium and tetraethylammonium sensitive potassium channels is demonstrated. Potassium conductance is shown to amount to 0.25--0.025 of sodium conductance. Dialysis of the cells by phosphate solutions induces a slow outward current, which is not inhibited by tetraethylammonium ions.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D002999:Clone Cells / Q000378:metabolism; D003956:Dialysis / Q000379:methods; D004553:Electric Conductivity; D005459:Fluorides / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism*; D010710:Phosphates / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*
D007473:Ion Channels; D010710:Phosphates; D005459:Fluorides; D011188:Potassium
Ionnye toki kul'tiviruemykh kletok neĭroblastomy klona N18 A-1 v usloviiakh vnutrikletochnogo dializa ftoridom i fosfatom kaliia.