[Modifications of disulfiram and its metabolites in blood in alcoholic hepatopathy (author's transl)].
In cirrhotic, steatosic and healthy subjects, the authors studied the metabolism of disulfiram (TETD) administrated orally (500 mg) 3 consecutive days. Carbon disulfide (CS2) and the whole TETD, diethyl dithiocarbamate (DDC) disulfides, were determined by a gas chromatographic method. The evolution of metabolites is similar in steatosic and healthy subjects. In cirrhotics the CS2, DDC and disulfides level increase within the 3 days. This phenomenon may be related with hepatic toxicity of TETD and with the persistence of disulfiram-alcohol reaction. The authors suggest to use low doses of disulfiram in cirrhotic.
D000328:Adult; D000368:Aged; D002246:Carbon Disulfide / Q000097:blood; D004221:Disulfiram / Q000097:blood*; D004050:Ditiocarb / Q000097:blood; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood; D008108:Liver Diseases, Alcoholic / Q000097:blood*; D008297:Male; D008875:Middle Aged
D004050:Ditiocarb; D002246:Carbon Disulfide; D004221:Disulfiram
Modifications des taux sanguins du disulfiram et de ses métabolites dans l'insuffisance hépato-cellularie d'origine alcoolique.