title: Effect of prostaglandins and dibutyryl cyclic AMP on the morphology of cells in primary astroglial cultures and on metabolic enzymes of GABA and glutamate metabolism.
abstract: Prostaglandins (PGE1) and dibutyryl cyclic AMP (dBc AMP) induce similar morphological changes in astrocytes obtained in primary cultures. PGE1 and dBc AMP increased 2 enzymes of GABA and glutamate metabolism, GABA-T and AAT, but did not modify GDH and GLN-S. Prostaglandins probably affect the cAMP content of glial cells and act in the same way as dBc AMP on glial cell differentiation.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000328:Adult; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D003994:Bucladesine / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D011458:Prostaglandins E / Q000494:pharmacology*; D000637:Transaminases / Q000378:metabolism*
chemical_list: D011458:Prostaglandins E; D003994:Bucladesine; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000612:4-Aminobutyrate Transaminase