Cyclic AMP-dependent protein kinase activity in human brain across age.
Cyclic AMP-dependent protein kinase activity was measured in the cerebral cortex of humans 2 days to 83 years of age and in the cortex of F344 rats 3, 22, or 30 months of age. Protein kinase activity was detected in the human brain, but no age-related differences in activity were observed in the presence or absence of cyclic AMP. Age differences were also not seen in protein kinase in the rat cerebral cortex. Enzyme activities in rat and human brain were similar.
D000328:Adult; D000368:Aged; D000375:Aging; D001921:Brain / Q000201:enzymology / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D000242:Cyclic AMP / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011494:Protein Kinases / Q000378:metabolism*
D000242:Cyclic AMP; D011494:Protein Kinases