The influence of beta blockers upon plasma cyclic AMP levels.
Beta adrenoreceptor blocking drugs with high intrinsic sympathomimetic activity (pindolol and alprenolol) produced significant elevation of plasma cyclic AMP levels, when compared to propranolol. In hypertensive patients, despite these marked differences in plasma cyclic AMP levels, similar blood pressure control was achieved with these three beta blockers.
D000526:Alprenolol / Q000494:pharmacology* / Q000627:therapeutic use; D000242:Cyclic AMP / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D010869:Pindolol / Q000494:pharmacology* / Q000627:therapeutic use; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use
D000526:Alprenolol; D011433:Propranolol; D010869:Pindolol; D000242:Cyclic AMP