Potassium stimulated 45Ca uptake by cortical slices of rat brain: effects of cyclic nucleotide derivatives.
The effects of dibutyryl cyclic GMP (db-cGMP) and dibutyryl cyclic AMP (db-cAMP) on potassium-stimulated 45Ca uptake by cortical slices of rat brain were investigated. db-cGMP specifically inhibited the initial rate of potassium-stimulated 45Ca uptake in a dose-dependent manner. Our findings supported the suggestion that cyclic GMP may play a regulatory role in depolarization-elicited Ca2+ influx in nerve endings in situ.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D003994:Bucladesine / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D006152:Cyclic GMP / Q000031:analogs & derivatives*; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D011188:Potassium / Q000494:pharmacology*; D051381:Rats
D003995:Dibutyryl Cyclic GMP; D003994:Bucladesine; D006152:Cyclic GMP; D011188:Potassium; D002118:Calcium