Influence of Bestatin, a new immunomodulator, on Ig secretion by human lymphocytes in vitro and in vivo.
Bestatin, a chemically well-defined immunomodulator, was tested for its capacity to interfere with PWM-induced Ig synthesis of peripheral lymphocytes from healthy donors. It was observed that secretion of IgA, IgG and IgM was impaired when Bestatin was present in the cultures. Serum Ig concentrations and antibody activities of IgG class to cytomegalovirus, herpes simplex and morbilli virus were examined in cancer patients who were treated with 30 mg of Bestatin daily for 1-21 weeks. These values remained constant during Bestatin treatment indicating that antibody secretion in vivo was not affected.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000096:biosynthesis; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins / Q000096:biosynthesis*; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008459:Measles virus / Q000276:immunology; D008875:Middle Aged; D011043:Pokeweed Mitogens / Q000494:pharmacology; D018139:Simplexvirus / Q000276:immunology
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D011043:Pokeweed Mitogens; D007073:Immunoglobulin E; D007930:Leucine; C012211:ubenimex