Opioid inhibition of dopamine release from nervous tissue of Mytilus edulis and Octopus bimaculatus.
Morphine and D-Ala2-Met-enkephalin as well as other opioids suppress potassium-stimulated release of 3H-labeled dopamine from neurons tissue of two marine invertebrates, Mytilus edulis and Octopus bimaculatus. Naloxone reverses the inhibitory effects in both species. Potassium-stimulated release of 3H-labeled serotonin is not altered by opioids. It is postulated that opiate receptors and their endogenous effectors play a prominent role in regulation of transmitter release in invertebrates.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004745:Enkephalins / Q000494:pharmacology; D005724:Ganglia / Q000378:metabolism; D008974:Mollusca / Q000502:physiology*; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D049831:Octopodiformes; D011957:Receptors, Opioid / Q000502:physiology; D012908:Snails; D009435:Synaptic Transmission / Q000187:drug effects
D004745:Enkephalins; D009294:Narcotics; D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine; D004298:Dopamine