Red cell pyrimidine 5'-nucleotidase and glutathione in myeloproliferative and lymphoproliferative disorders.
Red cell reduced glutatione (GSH) and pyrimidine 5'-nucleotidase (Pry 5'-NT) were measured in a variety of myeloproliferative and lymphoproliferative disorders. Raised levels of GSH were found in chronic lymphocytic leukaemia, Hodgkin's disease, non-Hodgkin's lymphoma, Waldenstrom's macroglobulinaemia and myeloma. Decreased activity of Pyr 5'-NT was found in acute myeloblastic leukaemia, acute lymphoblastic leukaemia, chronic granulocytic leukaemia, chronic lymphocytic leukaemia, Hodgkin's disease and non-Hodgkin's lymphoma. There was no correlation between the raised GSH levels and decrease Pry 5'-NT levels.
D000328:Adult; D004912:Erythrocytes / Q000378:metabolism; D005978:Glutathione / Q000097:blood*; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000201:enzymology; D008223:Lymphoma / Q000097:blood* / Q000201:enzymology; D009708:Nucleotidases / Q000097:blood*; D011743:Pyrimidines; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000201:enzymology
D011743:Pyrimidines; D009708:Nucleotidases; D005978:Glutathione