Involvement of prostaglandins in the local action of endotoxin.
Endotoxin from Gram-negative bacteria increases the permeability coefficient of albumin in isolated rat mesenteries used as a separating membrane between the two halves of a diffusion cell. Endotoxin also promotes cyclic AMP accumulation in similar mesenteric sheets. These effects are dose-related, and are inhibited by indomethacin. As shown by direct assay, Prostaglandin E-immunoreactive material is synthesized in the presence of endotoxin and is responsible for the increase in albumin permeability and for the increase in cyclic AMP.
D000418:Albumins / Q000378:metabolism; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008643:Mesentery / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats
D000418:Albumins; D004731:Endotoxins; D011458:Prostaglandins E; D000242:Cyclic AMP; D007213:Indomethacin