Reversal of guanethidine- and diethyldithiocarbamate-induced amnesia by peripherally-administered catecholamines.
The effect of peripherally-administered catecholamines on guanethidine- and diethyldithiocarbamate-induced amnesia of a PA training in mice was investigated. The amnesic effect of guanethidine could be blocked with 50 mg/kg DA, or 0.75 mg/kg NE when given either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could be attenuate the guanethidine-induced amnesia. The amnesic effect of diethyldithiocarbamate could be blocked with 50 mg/kg DA, 0.75 mg/kg NE or 0.5 mg/kg E when given either before, immediately or 10 ming after but not 90 min following PA. The amnesic effects of these compounds were interpreted in terms of their peripheral antiadrenergic actions.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology*; D004050:Ditiocarb / Q000037:antagonists & inhibitors*; D004298:Dopamine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006145:Guanethidine / Q000037:antagonists & inhibitors*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D013859:Thiocarbamates / Q000037:antagonists & inhibitors*
D002395:Catecholamines; D013859:Thiocarbamates; D004050:Ditiocarb; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine; D006145:Guanethidine