Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma: a prospective study.
In a prospective study of 104 infants between 1 and 3 months of age hospitalized with pneumonitis, 65 (63%) had evidence of infection with one or more potential respiratory pathogens. Single infections were noted in 48 (74%) whereas mixed infections occurred in 17 (26%) of 65 infected infants. The four most common infections were Chlamydia trachomatis (15/59, 25%), Ureaplasma urealyticum (8/38, 21%), cytomegalovirus (21/104, 20%), and Pneumocystis carinii (19/104, 18%). In sharp contrast, the incidence of these infections in control infants was 0% (0/25), 4% (2/49), 3% (3/97), and 0% (0/64), respectively. The clinical, radiologic, and laboratory characteristics of the pneumonitis syndrome associated with Chlamydia, cytomegalovirus, and Pneumocystis were indistinguishable from each other. Patients with mixed infections had a more severe pneumonitis as measured by the occurrence of apnea and the need of oxygen therapy an mechanical ventilation. The patients enrolled in this study are being followed-up to determine the longitudinal course of these infections.
D002690:Chlamydia Infections / Q000175:diagnosis / Q000382:microbiology; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009180:Mycoplasmatales Infections / Q000175:diagnosis / Q000382:microbiology; D011014:Pneumonia / Q000175:diagnosis / Q000382:microbiology; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000382:microbiology; D011446:Prospective Studies; D014509:Ureaplasma