title: Structural comparison of fibronectins from normal and transformed cells.
abstract: Comparative study of the structures of fibronectins from normal and transformed cells by partial proteolysis as well as by tryptic peptide fingerprinting and analysis of phosphorylation show that: 1) fibronectin molecules from normal and transformed cells probably have very similar primary structures; 2) the phosphorylation of fibronectin is a highly specific and conserved phenomenon; 3) fibronectin from both normal and transformed cells is phosphorylated only on serine residues; 4) although the major sites of phosphorylation in fibronectin are the same in normal and transformed cells, fibronectin from transformed cells appears to be phosphorylated to a much higher extent than that from normal cells.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics; D002460:Cell Line; D002472:Cell Transformation, Viral; D006224:Cricetinae; D005353:Fibronectins / Q000302:isolation & purification; D007668:Kidney; D008970:Molecular Weight; D010446:Peptide Fragments / Q000032:analysis; D051381:Rats; D014357:Trypsin
chemical_list: D000596:Amino Acids; D005353:Fibronectins; D010446:Peptide Fragments; D014357:Trypsin