[Changes in the cytochrone C and A (A3) content in the liver mitochondria of rats with hyperthyroidism].
Thyroxin was administered daily to male Wistar rats aged 1, 3, 12 and 24 months in a dose of 250 g per 100 g body weight. After 9 days there was a significant increase in the content of cytochromes c and a (a(3)). An appreciable rise in the cytochrome c content was recorded as long as after one day, whereas the content of cytochromes a (a(3)) did not exceed normal even after 2 days. Following one day the content of cytochromes a (a(3)) in 3-, 12-, and 24-month-old rats was sightly lower than in normal rats. A significant temporary increase in the c/a (a(3)) ratio was observed after 1-2 days only in 12- and 24-month-old rats. The c/a (a(3)) ratio increased with age. It is suggested that application of thyroid hormones may be promising in studies on the regulation of mitochondrial biogenesis.
D000375:Aging; D000818:Animals; D003574:Cytochrome c Group / Q000378:metabolism*; D003580:Cytochromes / Q000378:metabolism*; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D013974:Thyroxine / Q000008:administration & dosage; D013997:Time Factors
D003574:Cytochrome c Group; D003580:Cytochromes; D013974:Thyroxine
Izmeneniia soderzhaniia tsitokhromov C i A (A3) v mitokhondriiakh pecheni krys pri gipertireoze.