Human beta-endorphin: synthesis and biological activity of analogs with substitutions in positions 2, 9, 18, 27 and 31.
Four analogs of the opioid peptide human beta-endorphin (Bh-EP) have been synthesized: [D-Lys9, Phe27, Gly31]-beta h-EP, [D-PHe18,Phe27,Gly31]-beta h-EP, [D-Thr2,D-Lys9,Phe27,Gly31]-beta h-EP, and [D-Thr2,D-Phe18,Phe27,Gly31]-beta h-EP. All are practically indistinguishable from beta h-EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail-flick assay.
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D004723:Endorphins / Q000138:chemical synthesis*; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects; D051379:Mice; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin