Activation of promutagens by liver homogenates isolated from female mice at different ages; lack of significant differences.
Liver S-9 (9000 g supernatant) fractions isolated from 2-, 12- and 26-month untreated female Swiss-Webster mice were compared under different assay conditions as to their abilities to activate 2-acetylaminofluorene, benzo(a)pyrene, and dimethylnitrosamine to mutagens in Salmonella typhimurium tester strain TA 100. All fractions activated these compounds to mutagens, although 2-acetylaminofluorene was only weakly mutagenic. Some differences in the activating abilities of the three age groups were observed but they were for the most part relatively small.
D015073:2-Acetylaminofluorene / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism*; D001711:Biotransformation; D004128:Dimethylnitrosamine / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000378:metabolism*; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000378:metabolism
D001580:Benzopyrenes; D009153:Mutagens; D001564:Benzo(a)pyrene; D015073:2-Acetylaminofluorene; D004128:Dimethylnitrosamine