[Use of histological methods for the demonstration of the anti-inflammatory activity of fusafungin (author's transl)].
The anti-inflammatory activity of fusafungin may be demonstrated in guinea-pig, with use of morphological methods. Indeed, edema and congestion of the lamina propria of the trachea, break of cilia of the respiratory epithelium, which are witness of inflammation induced by acrolein, do not appear after treatment by fusafungin. However, the cellular phenomenons of inflammation do persist.
D000171:Acrolein / Q000008:administration & dosage; D000336:Aerosols / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents; D047630:Depsipeptides; D005670:Fusarium; D006168:Guinea Pigs; D006652:Histological Techniques; D007249:Inflammation / Q000473:pathology*; D008854:Microscopy, Electron; D014132:Trachea / Q000473:pathology / Q000648:ultrastructure
D000336:Aerosols; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D047630:Depsipeptides; C014001:fusafungin; D000171:Acrolein
L'utilisation de méthodes histologiques pour la démonstration de l'activité anti-inflammatoire de la fusafungine.