Acro-osteolysis (report of two cases and brief review of literature.
Two siblings suffering from acro-osteolysis, a rare disorder, are discussed. Although three distinct types of acro-osteolysis, namely familial, idiopathic, and due to vinyl-chloride, are clearly defined, these patients did not fit into any category. They had intact nails, preserved tactile and sensory system, plantar ulceration and so sensory deficit. Nerve conduction studies showed prolongation of motor distal latencies in median, ulnar, posterior tibial and lateral popliteal nerves. Nerve biopsies from both patients showed severe loss of myelinated fibres of all sizes, but more so of small ones.
D000293:Adolescent; D000328:Adult; D001862:Bone Resorption / Q000235:genetics*; D004576:Electromyography; D005260:Female; D005532:Foot Deformities, Congenital; D006801:Humans; D008297:Male; D009431:Neural Conduction; D010014:Osteolysis / Q000145:classification / Q000235:genetics* / Q000503:physiopathology; D013497:Sural Nerve / Q000473:pathology