title: [Spontaneous mononucleosis due to cytomegalovirus in otherwise healthy subjects. Prospective study of 28 cases (author's transl)].
abstract: Fever was a constant feature in 28 subjects with spontaneous mononucleosis due to cytomegalovirus and lasted 15 days or more in almost all cases (26/28). Blood mononucleosis and biochemical hepatic disorders were virtually always present but appeared later, so that the fever was initially thought to be "isolated". Splenomegaly was found in 39.3 p. cent of the cases. Skin rashes developed in 5 patients who had received ampicillin. Non-specific immunological abnormalities were detected in 8 of the 13 patients in whom they were looked for. The diagnosis was established by serological tests, which showed either a significant rise in, or (in patients seen at a late stage of the disease) high, sustained antibodies titers. The virus was found in blood in seven patients among the fourteen in whom it was looked for. We believe that these findings in otherwise healthy subjects could be termed "primary infection". The condition invariably followed a favourable course in the absence of any treatment. Contrary to what is observed in infectious mononucleosis, there was no sore throat and the Paul-Bunnel Davidsohn test always gave negative results.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000276:immunology; D005260:Female; D006801:Humans; D007244:Infectious Mononucleosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
vernacular_title: Syndromes mononucléosiques spontanés à cytomégalovirus survenant chez des individus sains. Etude prospective de 28 observations.