[DPA and clonazepam activity in febrile convulsions: preliminary results].
A pharmacological trial has been performed for the prophylaxis of febrile convulsions in childhood. The administration of two antiepileptic drugs, Sodium Valproate and Clonazepam, reduces significantly seizures occurrence compared with unmedicated controls. Furthermore, Sodium Valproate has been found to be more effective than Clonazepam. Both anticonvulsants are thought to act by a Gabaergic modulation in CNS.
D001570:Benzodiazepinones / Q000627:therapeutic use*; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D002998:Clonazepam / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D011956:Receptors, Cell Surface / Q000187:drug effects; D011963:Receptors, GABA-A; D012640:Seizures / Q000188:drug therapy*; D003294:Seizures, Febrile / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use*
D001570:Benzodiazepinones; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D002998:Clonazepam; D014635:Valproic Acid
Attivita' del clonazepam e del DPA sulle convulsioni febbrili: dati preliminari.