Prostaglandins, platelets, and schizophrenia.
Prostaglandin (PG) E1 enhances formation of 3H-adenosine-3',5'-cyclic monophasphate (3H-cAMP) in platelets pulse-labeled with 3H-adenine. This response was assessed as an index of receptor sensitivity and of PG function. Prostagladin E1-stimulated 3H-cAMP accumulation in paltelets from schizophrenics was significantly reduced compared with control subjects. Platelet incorporation of 3H-adenine and basal 3H-cAMP accumulation. We discuss the results in terms of the possible role of PGs in the etiopathology of schizophrenia and derivative implications for treatment.
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D000242:Cyclic AMP / Q000097:blood; D006801:Humans; D011458:Prostaglandins E / Q000502:physiology*; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy
D011458:Prostaglandins E; D011619:Psychotropic Drugs; D000242:Cyclic AMP