Plasma beta-endorphin responses to somatostatin, thyrotropin-releasing hormone, or vasopressin in Nelson's syndrome.
To elucidate the regulation of secretion of beta-endorphin in Nelson's syndrome, both ACTH and beta-endorphin were measured using RIA. We found that beta-endorphin and ACTH were secreted concomitantly in responses to the administration of lysine-8-vasopressin and TRH. Conversely, the administration of somatostatin to this patient reduced the secretion of both beta-endorphin and ACTH. Thus, beta-endorphin is probably secreted cooredinately with ACTH in patients with Nelson's syndrome.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D004723:Endorphins / Q000097:blood*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008236:Lypressin; D009347:Nelson Syndrome / Q000097:blood*; D010911:Pituitary Neoplasms / Q000097:blood*; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone
D004723:Endorphins; D008236:Lypressin; D013004:Somatostatin; D013973:Thyrotropin-Releasing Hormone; D000324:Adrenocorticotropic Hormone