Autoradiographic localization of 3H-diprenorphine in the Syrian hamster.
An autoradiographic technique is reported for the in vivo localization in the Syrian hamster of small doses of the opiate antagonist, 3H-diprenorphine. The regional distribution in the hamster brain was similar to that reported in the rat. The adrenal medulla showed a high degree of localization providing supportive evidence for the presence of opiate receptors in the medulla and a possible paracrine function for opioid peptides in this site. Other peripheral sites showed selective uptake of 3H-diprenorphine which was not apparently related to the vascularity of the tissue.
D000302:Adrenal Cortex / Q000032:analysis; D000313:Adrenal Medulla / Q000032:analysis*; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry; D006224:Cricetinae; D004174:Diprenorphine / Q000032:analysis*; D008647:Mesocricetus; D009019:Morphinans / Q000032:analysis*; D010179:Pancreas / Q000032:analysis; D051381:Rats; D011957:Receptors, Opioid / Q000502:physiology; D013363:Submandibular Gland / Q000032:analysis
D009019:Morphinans; D011957:Receptors, Opioid; D004174:Diprenorphine