The release of neurohypophysial hormones as influenced by stimulation of alpha-adrenergic transmission in long-term dehydrated male white rats. Information 1: hypothalamic and neurohypophysial vasopressor activity.
Rats dehydrated up to 12 days were given intraperitoneally methoxamine hydrochloride in a daily dose of 1.0 mg/100 g of the initial body weight. The single dose of methoxamine administered to normally hydrated animals was followed by a significant increase of the vasopressin content of the neurohypophysis and hypothalamus (both in NSO and NPV regions). Under conditions of severe dehydration a more marked depletion of hypothalamic and neurohypophysial vasopressin stores was noted in methoxamine-treated animals.
D000818:Animals; D003681:Dehydration / Q000503:physiopathology*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D008729:Methoxamine / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000378:metabolism*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D013268:Stimulation, Chemical; D013495:Supraoptic Nucleus / Q000378:metabolism*; D013997:Time Factors; D014667:Vasopressins / Q000378:metabolism*
D011942:Receptors, Adrenergic, alpha; D014667:Vasopressins; D008729:Methoxamine