Histidine is the axial ligand to cytochrome alpha 3 in cytochrome c oxidase.
The nitric oxide-bound complexes of reduced yeast cytochrome c oxidase incorporated with [1,3-15N2]histidine have been investigated by EPR spectroscopy. The results of this study have allowed the unambiguous identification of histidine as the endogenous axial ligand to cytochrome alpha 3.
D001665:Binding Sites; D003574:Cytochrome c Group / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006639:Histidine / Q000032:analysis*; D008024:Ligands; D009587:Nitrogen Isotopes; D011485:Protein Binding; D012441:Saccharomyces cerevisiae / Q000201:enzymology
D003574:Cytochrome c Group; D008024:Ligands; D009587:Nitrogen Isotopes; D006639:Histidine; D003576:Electron Transport Complex IV