Comparative sequence analysis of the inverted terminal repetitions from different adenoviruses.
The comparative nucleotide sequences of the region of inverted terminal repetition from a representative member of group C (nononcogenic), group B (weakly oncogenic), and group A (highly oncogenic) adenoviruses are analyzed. Our data show that (i) the length of this unique region increases with the oncogenicity of the serotype, (ii) a unique homologous region--14 nucleotides long--is present exactly at the same distance from the terminus, and (iii) a hexanucleotide sequence, T-G-A-C-G-T, is present at the site where the terminal repetition diverges.
D000260:Adenoviruses, Human / Q000235:genetics* / Q000472:pathogenicity; D001483:Base Sequence; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
D004279:DNA, Viral; D004262:DNA Restriction Enzymes