[Hormonal stimulation after injection of thyrotrophin releasing factor (TRF) and 1-24 ACTH in patients following chronic treatment with neuroleptics (author's transl)].
Fifteen patients with neuroleptic treatment (haloperidol 4 to 6 mg a day or phenothiazines) and eleven control patients were given TRH 250 microgram i.v. and 1-24 ACTH, i.m. different times, TSH, T3, T4, FT4, Prolactin (PRL) cortisol were measured. Before TRH injection, at baseline, TSH is higher (p less than 0,01) and T3 lower (p less than 0,05) in the neuroleptics treated group than in the control group. These results suggest the occurrence of a biological hypothyroidism in the group with neuroleptics; moreover PRL is significantly increased. After TRH injection the response is not significantly different between the two groups. Cortisol level is lower at baseline and after 1-24 ACTH injections in the group with neuroleptics.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000328:Adult; D000368:Aged; D003366:Cosyntropin; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy*; D008875:Middle Aged; D010640:Phenothiazines / Q000627:therapeutic use*; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D010640:Phenothiazines; D014284:Triiodothyronine; D003366:Cosyntropin; D013973:Thyrotropin-Releasing Hormone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D006220:Haloperidol; D013974:Thyroxine; D006854:Hydrocortisone
Résultats des tests de stimulation par le facteur de libération de la thyrostimuline (TRF) et par le fragment 1-24 de l'hormone corticotrope chez des sujets traités au long cours par des neuroleptiques. Etude préliminaire.