The new histamine H2-receptor antagonist ranitidine. Duration of action.
The antisecretory effects of a new histamine H2-receptor antagonist, ranitidine hydrochloride, have been investigated on basal and pentagastrin-stimulated acid secretion in healthy volunteers 5 and 10 h after oral administration of 150 mg. In addition, the 24-h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition after three doses of 150 mg ranitidine per day. A 40% inhibition of basal acid output has been noted even 10 h after drug intake. The intragastric pH-values were raised above 5 for at least 24 h. The new H2-antagonist ranitidine has been proven to be a potent and long-acting antisecretory compound.
D000328:Adult; D005663:Furans / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D011899:Ranitidine; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D012636:Secretory Rate / Q000187:drug effects
D005663:Furans; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D011899:Ranitidine; D010418:Pentagastrin