title: Comparative therapeutic effects of vitamin D3 and its derivatives on experimental renal osteodystrophy.
abstract: The comparative effectiveness of vitamin D3 and its derivatives in curing hyperparathyroidism and osteodystrophic bone lesions was examined in a laboratory model of renal osteodystrophy associated with marked secondary hyperparathyroidism in rats. The experimental model was prepared by a single injection of homologous glycopeptide. Plasma levels of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] appeared to decrease in the rats receiving glycopeptide. Various doses of vitamin D3 derivatives [2 or 10 microgram/kg D3, 2 microgram/kg 25-hydroxyvitamin D3 (25OHD3), 0.1 microgram/kg 1 alpha,25(OH)2D3, and 0.1 or 0.2 microgram/kg 1 alpha-hydroxyvitamin D3 (1 alpha OHD3)] were daily administered orally to the nephritic rats for 23 days before sacrifice. 1 alpha,25(OH)2D3 and 1 alpha OHD3 were much more potent than 25OHD3 and D3 in reducing the hyperplasia of parathyroir glands. The potency of 1 alpha OHD3 in curing the histological changes of osteodystrophy appeared to be greater than that of 1 alpha,25(OH)2D3. The same dose level of 1 alpha OHD3 was more effective than 1 alpha,25(OH)2D3 in enhancing plasma 1 alpha,25(OH)2D3 levels.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D002762:Cholecalciferol / Q000494:pharmacology / Q000627:therapeutic use*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004100:Dihydroxycholecalciferols / Q000494:pharmacology; D004195:Disease Models, Animal; D006020:Glycopeptides; D006887:Hydroxycholecalciferols / Q000494:pharmacology; D010280:Parathyroid Glands / Q000187:drug effects; D010281:Parathyroid Hormone / Q000097:blood; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D004100:Dihydroxycholecalciferols; D006020:Glycopeptides; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D002762:Cholecalciferol; D002118:Calcium