[Effect of intracellular injections of cyclic adenosine monophosphate on the electrical characteristics of identified edible snail neurons].
Electrical activity of silent RPa3, LPa2, LPa3, LPa8, LP11 neurons and spontaneously active RPa1 neuron was investigated as affected by iontophoretic intracellular cAMP injection. It is shown that in all cases the cAMP injection caused depolarization of the membrane; cAMP injection into the neuron when its membrane potential is clamped at the resting potential level evoked the appearance of transmembrane current (cAMP-current). External theophylline (1 mM/1) increased the amplitude and duration of vAMP-current approximately by 50%. It is concluded that variation in the cAMP concentration inside the neuron may alter the ionic permeability of its membrane, thus changing its electrical activity.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology*; D006372:Helix, Snails / Q000502:physiology*; D007478:Iontophoresis; D008433:Mathematics; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology
D013806:Theophylline; D000242:Cyclic AMP
Vliianie vnutrikletochnoĭ in"ektsii tsiklicheskogo adenozinmonofosfata na élektricheskie kharakteristiki identifitsirovannykh neĭronov vinogradnoĭ ulitki.