Inhibitory effects of an aromatic retinoid (Ro 10-9359) on viral tumorigenesis.
Prophylactic treatment of hamsters and chickens with an aromatic retinoid (Ro 10-9359) inhibited Rous sarcoma virus (RSV) tumorigenesis. Retinoid administration to chickens with RSV-induced tumors resulted in tumor regression and/or confinement to the primary site. The retinoid also exerted a therapeutic effect on Shope virus papilloma development in the skin of rabbits.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001354:Avian Leukosis Virus / Q000276:immunology; D001358:Avian Sarcoma Viruses / Q000254:growth & development; D002645:Chickens; D006224:Cricetinae; D005050:Etretinate / Q000627:therapeutic use*; D008647:Mesocricetus; D051379:Mice; D001357:Sarcoma, Avian / Q000188:drug therapy / Q000517:prevention & control*; D014212:Tretinoin / Q000031:analogs & derivatives*; D014412:Tumor Virus Infections / Q000188:drug therapy*
D000914:Antibodies, Viral; D014212:Tretinoin; D005050:Etretinate