[Action of a vitamin complex with oxidative-reductive properties on the course of acute myocardial hypoxia and ischemia].
Experiments on mice with simulated isobaric hypoxia and anoxia have demonstrated marked antihypoxic action of a complex of vitamins with electron-acceptor activity (ascorbic acid, riboflavine mononucleotide, lipoic acid, nicotinamide). In dog experiments, the complex of vitamins reduced metabolic acidosis in the ischemia zone as shown by the lactate release test and increased the collateral coronary circulation. The protective action of the drug recorded in hypoxia and regional myocardial ischemia is regarded as linked with the ability of the vitamin complex to raise the conjugation of oxidation and phosphorylation in the mitochondria of a pathologically altered myocardium, as well as with its membrane-stabilizing action and inhibition of lipid peroxidation.
D000208:Acute Disease; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009536:Niacinamide / Q000627:therapeutic use; D010084:Oxidation-Reduction / Q000187:drug effects; D012256:Riboflavin / Q000627:therapeutic use; D008063:Thioctic Acid / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D014815:Vitamins; D009536:Niacinamide; D008063:Thioctic Acid; D001205:Ascorbic Acid; D012256:Riboflavin
Deĭstvie kompleksa vitaminov s okislitel'no-vosstanovitel'nymi svoĭstvami na techenie ostroĭ gipoksii i ishemii miokarda.