Effect of cyproterone acetate on structure of adrenal cortex in hypophysectomized, ACTH treated mice.
Hypophysectomized adult male C57BL/6J mice injected with 0.08 mg/g of cyproterone acetate showed large aggregates of cellular lipid as well as nodular formations in the zona fasciculata of the adrenal cortex. Daily ACTH injections (10 IU) reversed the atrophic changes noted above. At the ultrastructural level, the zona fasciculata and zona reticularis cells exhibited decreased cellular lipid content, proliferated profiles of rough endoplasmic reticulum, an increase in polyribosomes, and an active Golgi apparatus. It is believed that cyproterone acetate inhibited adrenocortical steroidogenesis by interfering with pituitary release of ACTH.
D000302:Adrenal Cortex / Q000187:drug effects / Q000648:ultrastructure*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003534:Cyproterone / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D011132:Polyribosomes / Q000648:ultrastructure; D012270:Ribosomes / Q000648:ultrastructure
D000324:Adrenocorticotropic Hormone; D003534:Cyproterone