title: Centrally mediated pressor response to metiamide as a result of GABA-receptor antagonism.
abstract: The mechanism of the pressor response to metiamide was examined in anesthetized cats. Intravenous administration of metiamide had no effect on blood pressure. Infusion into the lateral ventricle (10 mg/kg/min for 10 min), caused a marked pressor response which was due to an increase in sympathetic outflow since pretreatment of cats with guanethidine completely prevented it. In a rat brain synaptosome preparation, both metiamide and cimetidine displaced [3H] CABA. These data strongly suggest that metiamide increases blood pressure in the cat through a central mechanism involving GABA-receptor antagonism.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002415:Cats; D002927:Cimetidine / Q000378:metabolism; D008785:Metiamide / Q000378:metabolism / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D011963:Receptors, GABA-A; D013890:Thiourea / Q000031:analogs & derivatives*
chemical_list: D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D008785:Metiamide; D002927:Cimetidine; D013890:Thiourea