title: Further studies on opiate receptors that mediate antinoception: tooth pulp stimulation in the dog.
abstract: 1 The antinociceptive activities of morphine, codeine and dextropropoxyphene (micro-agonists), buprenorphine and Mr 2034 [(-)5,9-dimethyl-2-(tetrahydrofurfuryl)-2'-hydroxy-6,7-benzomorphan](k-agonists ) have been determined against nociceptive responses to electrical stimulation of the tooth pulp in the conscious dog. 2 Dose-dependent increases in nociceptive threshold were obtained for all of the analgesic drugs tested at doses within their antinociceptive range as determined in nociceptive pressure and chemical tests in rodents.
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D003782:Dental Pulp / Q000502:physiology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D008297:Male; D010146:Pain / Q000503:physiopathology*; D011957:Receptors, Opioid / Q000502:physiology*
chemical_list: D000700:Analgesics; D011957:Receptors, Opioid