[Effect of aldosterone on the metabolic quotient of (Na+, K+)-dependent adenosine triphosphatase from the rat brain and kidney].
The authors examined the metabolic number of the enzyme (Na+, K+)-dependent adenosintriphosphatase (EK 3.6.1.3) in adrenalectomized, intact and chronically treated with aldosterone adrenalectomized animals. They accepted the amount of hydrolized ATF/one combining site for an unit of time as a metabolic number. They found that adrenalectomy lowered the specific enzymic activity in renal tissue and did not alter in the brain tissue. Aldosterone, administered intraperitoneally, in a dose of 10 mg per 100 mg of body weight daily for a period of 5 days, increased the specific enzymic activity in the examined both tissues. The metabolic number of the enzyme diminished after adrenalectomy in the brain and kidney and increased over the level of the control animals after administration of aldosterone.
D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D000450:Aldosterone; D000254:Sodium-Potassium-Exchanging ATPase
Vllianie na aldosterona vŭrkhu obmennoto chislo na (NA+, K+)-zavisimata adenozin trifosfataza ot mozŭk i bŭbrek na plŭkh.