The release of neurohypophysial hormones as influenced by stimulation of alpha-adrenergic transmission in long-term dehydrated male white rats. Information 2: hypothalamic and neurohypophysial oxytocic activity.
Rats dehydrated up to 12 days were given intraperitoneally methoxamine hydrochloride in a daily dose of 1.0 mg/100 g of initial body weight. The only dose of methoxamine injected into normally hydrated animals did not influence significantly the oxytocic activity neither in the hypothalamus nor in the neural lobe. Following four days of dehydration a distinctly more marked depletion of the hypothalamic (both in the NSO and NPV region) and neurohypophysial oxytocin content was found in animals treated with methoxamine. For the neurohypophysis, a similar effect has been noted under severe dehydration (8th and 12th day) as well.
D000818:Animals; D003681:Dehydration / Q000503:physiopathology*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D008729:Methoxamine / Q000494:pharmacology*; D010121:Oxytocin / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000378:metabolism*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D013268:Stimulation, Chemical; D013495:Supraoptic Nucleus / Q000378:metabolism*; D013997:Time Factors
D011942:Receptors, Adrenergic, alpha; D010121:Oxytocin; D008729:Methoxamine