Role of adenosine deaminase in activation of macrophages.
The intracellular adenosine deaminase activity of induced macrophages was twice that of resident cells. Coformycin, a specific inhibitor of adenosine deaminase, inhibited the activation of macrophages, as measured by superoxide generation.
D000243:Adenosine Deaminase / Q000172:deficiency / Q000378:metabolism*; D000818:Animals; D000936:Antigen-Antibody Complex; D002469:Cell Separation; D003070:Coformycin / Q000494:pharmacology; D006168:Guinea Pigs; D007153:Immunologic Deficiency Syndromes; D008264:Macrophages / Q000276:immunology*; D009504:Neutrophils; D009700:Nucleoside Deaminases / Q000378:metabolism*; D011961:Receptors, Fc; D013481:Superoxides / Q000096:biosynthesis
D000936:Antigen-Antibody Complex; D011961:Receptors, Fc; D003070:Coformycin; D013481:Superoxides; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase