title: [Endorphins: neuromodulators and hormones (author's transl)].
abstract: The discovery of opiate receptors has resulted in the isolation of endogenous morphinomimetics called endorphins. The enkephalins, which are pentapeptides, are located diffusely within the brain and are thought to act locally as neuromodulators for the release of noradrenaline, dopamine and substance P. beta-endorphin, a peptide with 31 aminoacids, is released from the pituitary with ACTH during stress. The peptide sequency of the common precursor of these hormones, pro-opiocortin, is now established.
mesh_terms: D001921:Brain / Q000502:physiology; D004723:Endorphins / Q000096:biosynthesis / Q000502:physiology*; D004745:Enkephalins / Q000502:physiology*; D006801:Humans; D010146:Pain / Q000503:physiopathology; D011957:Receptors, Opioid / Q000502:physiology
chemical_list: D004723:Endorphins; D004745:Enkephalins; D011957:Receptors, Opioid
vernacular_title: Les endorphines: neuromodulateurs et hormones.