[Effect of chronic administration of cimetidine on adenohypophysis secretion in children].
In view of the existing disagreement on the hormonal effects of a chronic treatment with cimetidine, we have studied on a sample of 18 children, the possible alterations that might occur. A comparison has been established between basal conditions and a two-month treatment with 500 mg. a day, on levels of GH, PRL, LH, FSH, TSH and cortisol (as an indirect measurement of ACTH). The statistic study has not shown any noticeable difference in the considered period of time, and dose that has been used does not provoke any alteration in adenohypophyseal secretion.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D002648:Child; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D010908:Pituitary Hormones, Anterior / Q000097:blood*; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D006146:Guanidines; D010908:Pituitary Hormones, Anterior; D002927:Cimetidine; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone
Efectos de la administración crónica de cimetidina sobre la secreción adenohipofisaria en miños.