[Radiation modulation of the activity of the enzymatic systems in isolated plasma membranes in early ontogeny].
The activity of adenylate cyclase (Ac), cAMP phosphodiesterase (PDE) and 5'-nucleotidase was studied in plasma membranes from the liver of rat embryo of the 20th day of development normally and after exposure to ionizing radiation. Gamma-irradiation of plasma membranes with doses ranging from 0.1 to 100 kR was shown to inhibit the activity of Ac, this effect being more pronounced during stimulation with higher doses of isoproterenol. The activity of 5'-nucleotidase and PDE remained unchanged up to the dose of 100 kR.
D000262:Adenylyl Cyclases / Q000528:radiation effects*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D004789:Enzyme Activation / Q000528:radiation effects; D005720:Gamma Rays; D066298:In Vitro Techniques; D008099:Liver / Q000196:embryology / Q000201:enzymology; D009708:Nucleotidases / Q000528:radiation effects*; D010727:Phosphoric Diester Hydrolases / Q000528:radiation effects*; D051381:Rats
D000242:Cyclic AMP; D009708:Nucleotidases; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases
Radiatsionnaia moduliatsiia aktivnosti nekotorykh fermentnykh sistem izolirovannykh plazmaticheskikh membran rannego ontogeneza.