Response of pregnant mares to equine herpesvirus 1 (EHV1).
Twenty-one pregnant mares were inoculated with EHV1. Nineteen became infected as evidenced by clinical signs and/or viremia but only one mare aborted a virus-infected fetus. The viremias were leukocyte-associated and appeared to be non-productive, latent infections of these cells. Infectivity, detectable by cocultivation, persisted in the circulating leukocytes for as long as 9 days without resulting in abortion. The data suggest that it is extremely difficult to evaluate the efficacy of vaccines in preventing EHV1 (Rhinopneumonitis) abortion due to the paucity of non-exposed mares, lack of tests which measure residual protection, and an incomplete understanding of the pathogenic mechanisms involved in abortion due to this virus.
D000034:Abortion, Veterinary / Q000209:etiology / Q000382:microbiology; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D005260:Female; D005334:Fever / Q000662:veterinary; D006566:Herpesviridae Infections / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000276:immunology / Q000302:isolation & purification; D006734:Horse Diseases / Q000209:etiology* / Q000382:microbiology; D006736:Horses; D007962:Leukocytes / Q000382:microbiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*; D014766:Viremia / Q000662:veterinary
D000914:Antibodies, Viral