Serum 1,25-dihydroxycholecalciferol in anephric, haemodialyzed and kidney-transplanted patients. Effect of vitamin D3 supplement.
The serum levels of 25-hydroxycholecalciferol (25-OHD3) and 1,25-dihydroxycholecalciferol[1,25-(OH)2D3] were measured simultaneously in nephrectomized patients on maintenance haemodialysis, in haemodialyzed patients with preserved kidneys who were receiving different vitamin D supplement, and in patients who had undergone renal transplantation. The results indicate that the production of 1,25-(OH)2D3 can be stimulated in patients with minimal residual renal excretory function by increasing the serum levels of 25-OHD3. Successful renal transplantation was followed by a rise in serum 1,25-(OH)2D3 concentrations.
D000941:Antigens; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000627:therapeutic use; D004100:Dihydroxycholecalciferols / Q000096:biosynthesis / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000188:drug therapy; D016030:Kidney Transplantation; D008274:Magnesium / Q000097:blood; D009392:Nephrectomy; D010281:Parathyroid Hormone / Q000276:immunology; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis; D014184:Transplantation, Homologous
D000941:Antigens; D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D002762:Cholecalciferol; D010758:Phosphorus; D008274:Magnesium; D002118:Calcium