title: Leukaemia reactivates mouse cytomegalovirus.
abstract: An established model for latency by mouse cytomegalovirus (MCMV) was used to assess the effects of leukaemia on reactivation of MCMV. After inoculation of 400 spleen focus-forming units of Friend leukaemia virus (FLV), a significant number of mice yielded MCMV in salivary glands and kidneys 4 to 5 weeks later. Administration of cyclophosphamide during FLV infection increased the percentage of MCMV-positive animals. These results suggest that cytomegalovirus infections in leukaemic patients may reactivate as a result of the leukaemia itself and may be exacerbated by chemotherapy.
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D003587:Cytomegalovirus / Q000254:growth & development; D003586:Cytomegalovirus Infections / Q000150:complications*; D005622:Friend murine leukemia virus; D007942:Leukemia, Experimental / Q000150:complications*; D051379:Mice; D014775:Virus Activation / Q000187:drug effects
chemical_list: D003520:Cyclophosphamide