Studies of the immune response against a polyoma virus-induced fibrosarcoma in BALB mice using the Winn's tumor neutralization assay.
Rejection of a polyoma-virus induced fibrosarcoma was studied by the adoptive tumor neutralization assay. This assay showed that polyoma immune spleen cells had a specific growth inhibiting effect on admixed polyoma tumor cells; they only delayed the tumor growth of an irrelevant cell line. We provide evidence both for the role of T-cells in this rejection and for a possible participation of macrophages. T-cells action was not strictly H-2 restricted but H-2 preference was observed. Adoptive protection of nude mice showed that T-cells of the recipient did not participate in the reaction.
D000818:Animals; D005354:Fibrosarcoma / Q000276:immunology*; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009500:Neutralization Tests; D011120:Polyomavirus / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology*