title: Increased resting and evoked release of transmitter following repetitive electrical tetanization in hippocampus: a biochemical correlate to long-lasting synaptic potentiation.
abstract: In vitro stimulation of two axonal branches from hippocampal CA3 pyramids, the CA1 afferent Schaffer collaterals and the CA3 efferents to septum through fimbria, released D-[3H]aspartate as a measure for endogenous L-glutamate. Following bursts of repetitive electrical stimuli to the Schaffer collaterals, a long-lasting and significantly increased resting efflux, as well as an increased stimulus evoked release of D-aspartate, appeared. No such persistent increase in D-aspartate efflux was recorded from the septal terminals. We propose that increased transmitter liberation may account for long-term synaptic potentiation in hippocampus.
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology; D046508:Culture Techniques; D004558:Electric Stimulation; D005071:Evoked Potentials; D006168:Guinea Pigs; D006624:Hippocampus / Q000502:physiology*; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D012688:Septum Pellucidum / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D001224:Aspartic Acid; D002118:Calcium