Dependence of the metabolic fate of IMP on the rate of total IMP synthesis. Studies in cultured fibroblasts from normal subjects and from purine-overproducing mutant patients.
D002478:Cells, Cultured; D003839:Deoxyadenosines / Q000494:pharmacology; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency*; D007291:Inosine Monophosphate / Q000096:biosynthesis* / Q000378:metabolism; D007292:Inosine Nucleotides / Q000096:biosynthesis*; D007700:Kinetics; D009154:Mutation; D010710:Phosphates / Q000494:pharmacology; D010770:Phosphotransferases / Q000378:metabolism*; D012268:Ribose-Phosphate Pyrophosphokinase / Q000378:metabolism*
D003839:Deoxyadenosines; D007292:Inosine Nucleotides; D010710:Phosphates; D007291:Inosine Monophosphate; D007041:Hypoxanthine Phosphoribosyltransferase; D010770:Phosphotransferases; D012268:Ribose-Phosphate Pyrophosphokinase