Occupational asthma: a challenge in patient management and community care.
Occupational exposure to irritants accounts for 2% to 15% of all cases of asthma. Most of the offending agents evoke an IgE allergic reaction, but some seem to act through pharmacologic rather than immunologic pathways. Usually, symptoms are worse during working hours and improve in the evening and over the weekend, but in some cases onset is delayed. Symptoms may persist for weeks after exposure ceases. Skin tests or serologic tests for IgE antibody are helpful in diagnosis. Bronchial challenge with the suspected agent is valuable research procedure that occasionally is clinically useful in diagnosis. Management requires the cooperation of the medical and industrial communities. It consists of identifying asthmatic workers, removing them from exposure to the affecting environment, and treating their symptoms; preventing exposure of susceptible people through preemployment screening; and setting and adhering to reasonable occupational safety standards.
D001249:Asthma / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D004781:Environmental Exposure; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D009784:Occupational Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D009787:Occupational Medicine; D012882:Skin Tests; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects; D014481:United States
D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E