title: Differential diagnosis of hypoparathyroid disorders during childhood.
abstract: Changes in the plasma and urinary adenosine 3', 5' monophosphate (cyclic AMP) levels on infusion of parathyroid hormone were studied in 10 normal children, 5 children with idiopathic hypoparathyroidism, and 3 children with pseudohypoparathyroidism. In normal children the plasma concentration of cyclic AMP ranges from 18.0 to 68.0 pmoles/ml under basal conditions, and increases to a peak of about 10-fold the basal level 5 min after infusion of parathyroid hormone. Infusion of parathyroid hormone caused no increase in plasma cyclic AMP in patients with pseudohypoparathyroidism but about 18-fold increase in those with idiopathic hypoparathyroidism. The measurement of plasma cyclic AMP before and 5 min after infusion of parathyroid hormone is concluded to be a single and effective method for differential diagnosis of hypoparathyroid disorders.
mesh_terms: D002648:Child; D002675:Child, Preschool; D000242:Cyclic AMP / Q000097:blood* / Q000652:urine; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000175:diagnosis*; D007223:Infant; D007263:Infusions, Parenteral; D008297:Male; D010281:Parathyroid Hormone
chemical_list: D010281:Parathyroid Hormone; D000242:Cyclic AMP