Platelet and erythrocyte-membrane adenosine triphosphatase activity in depressive and manic-depressive illness.
An investigation of Mg2+ and (Na+ + K+)-dependent adenosine triphosphatase (ATPase) activities in the platelet and erythrocyte membrane of 44 depressive and 44 manic-depressive patients was carried out before and during (for 3 weeks to less than 1 year) drug treatment. When compared with normal controls (n = 43), the patients showed significantly elevated enzyme activities during both the drug-free and drug treatment periods. No remarkable changes in enzyme activities were observed between the drug-free and drug treatment (even long-term drug treatment) periods. Results suggest an alteration of cell-membrane activity, which may reflect changes in (1) ATP level, (2) cationic balance, (3) membrane phospholipid, or some combination thereof.
D000251:Adenosine Triphosphatases / Q000097:blood*; D000328:Adult; D001692:Biological Transport; D001714:Bipolar Disorder / Q000188:drug therapy / Q000201:enzymology*; D001792:Blood Platelets / Q000201:enzymology*; D002412:Cations; D003866:Depressive Disorder / Q000188:drug therapy / Q000201:enzymology*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D002412:Cations; D008094:Lithium; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium