Effects in vitro of serum from patients with Landry-Guillain-Barré syndrome of alcoholic peripheral neuropathy on outgrowth of rat dorsal root ganglia.
Cultures of three-day-old rat dorsal root ganglia were grown in control media containing human cord serum or in experimental media containing serum from patients with Landry-Guillain-Barré syndrome, alcoholic peripheral neuropathy, or normal adults. Analysis of variance in control cultures showed that there was a falloff of mean outgrowth length during active myelination by fourteen days, while cultures grown in the three experimental media had a greater outgrowth length and did not form myelin.
D000437:Alcoholism / Q000097:blood*; D000818:Animals; D001369:Axons / Q000648:ultrastructure; D005727:Ganglia, Spinal / Q000254:growth & development* / Q000648:ultrastructure; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D008854:Microscopy, Electron; D010523:Peripheral Nervous System Diseases / Q000097:blood*; D011129:Polyradiculoneuropathy / Q000097:blood*; D051381:Rats; D012583:Schwann Cells / Q000648:ultrastructure; D013577:Syndrome
D007106:Immune Sera