title: GABA receptors are increased in brains of alcoholics.
abstract: gamma-Aminobutyric acid (GABA) receptor binding was increased in postmortem brain samples of chronic alcoholic patients compared to control patients. Numbers of binding sites were augmented in alcoholic brain, with no change in affinity. Muscarinic cholinergic and benzodiazepine receptors did not differ between controls and alcoholic brains, while a modest reduction in beta-adrenergic receptors may have been related to postmortem receptor changes. The results suggest that GABAergic mechanisms might play a role in chronic alcoholism.
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000378:metabolism*; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011963:Receptors, GABA-A; D009435:Synaptic Transmission / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D000431:Ethanol; D005680:gamma-Aminobutyric Acid