A selective distribution pattern of different opiate receptors in certain areas of rat brain as revealed by in vitro autoradiography.
A differential localization of binding sites in the rat brain for [3H]D-Ala2,Leu5-enkephalin ([3H]DADL) and [3H]etorphine ([3H]Eto) was been demonstrated by an in vitro autoradiography technique. Labeling with [3H]DADL was found predominantly in septum and paraventricular nuclei of hypothalamus, whereas [3H]Eto labeling was primarily observed in the periaqueductal gray and several thalamic nuclei. The distinctive patterns of labeling by the two ligands in certain central nervous system structures suggests the existence of specific neuronal pathways which are preferentially labeled with either [3H]DADL or [3H]Eto.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D016308:Enkephalin, Leucine-2-Alanine; D004745:Enkephalins / Q000378:metabolism; D005048:Etorphine / Q000378:metabolism; D008297:Male; D051381:Rats; D011957:Receptors, Opioid / Q000032:analysis*
D004745:Enkephalins; D011957:Receptors, Opioid; D005048:Etorphine; D016308:Enkephalin, Leucine-2-Alanine