[Histochemical investigations on human bladder cancer (author's transl)].
The histochemical enzyme activity of alkaline phosphatase, nonspecific esterase, 5-nucleotidase, beta-glucuronidase, glucose-6-phosphatase, succinate dehydrogenase, and glucose-6-phosphate dehydrogenase in human bladder cancer was investigated. Tumors of 84 patients, classified into grades I-III according to the WHO classification, were compared with 12 normal and 16 inflamed bladder epithelia. As a rule, loss of alkaline phosphatase activity and a decrease of nonspecific esterase activity was found in most of these tumors. The activity of beta-glucuronidase was decreased and compared with normal tissue, also the activity of 5-nucleotidase. The succinate dehydrogenase activity in tumor tissue was frequently increased, whereas glucose-6-phosphate dehydrogenase did not show any significant reaction.
D015720:5'-Nucleotidase; D000469:Alkaline Phosphatase / Q000378:metabolism; D003556:Cystitis / Q000201:enzymology; D004950:Esterases / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D009708:Nucleotidases / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism; D001743:Urinary Bladder / Q000201:enzymology; D001749:Urinary Bladder Neoplasms / Q000201:enzymology*
D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D004950:Esterases; D009708:Nucleotidases; D000469:Alkaline Phosphatase; D015720:5'-Nucleotidase; D005952:Glucose-6-Phosphatase; D005966:Glucuronidase
Histochemische Untersuchungen an menschlichen Harnblasentumoren.