Behavioral and biochemical effects of intraventricular kainic acid.
Wistar rats received intraventricularly solutions of kainic acid (KA) and behavioral symptoms and changes in the brain concentrations of biogenic amines and 5-hydroxy-indole-acetic acid (5-HIAA) following the injection were observed. KA produced a characteristic behavioral syndrome dominated by episodes of "wet dog shakes" (WDS), which were most frequent after doses of 0.25-1.5 nmole, 10-25 min after the injection. Multiple injections of KA produced only negligible inhibition of the response in initial experiments, and the effect was significantly below the control level on the 6th consecutive treatment. WDS were more frequent in rats which had undergone central chemosympathectomy with 6-hydroxydopamine. Serotoninolytics did not inhibit WDS; the shakes were strongly inhibited by pretreatment with compounds inhibiting the transmission in the noradrenergic neurons, clonidine and aceperone, by a neuroleptic, spiperone, and by opiates stimulating the opiate receptor; morphine, azidomorphine and N-cyclopropylmethylnorazido-morphine, but not by an opiate receptor antagonist, naloxone. KA depressed the cerebral level of norarenaline 35 min after the administration, byt 6 days after a single injection the brain levels of noradernaline and 5-HIAA were elevated. It i suggested that the catecholaminergic systems and opiate receptors play an important role in the syndrome observed, and that the syndrome resembles the syndrome of morphine abstinence.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D013997:Time Factors
D011759:Pyrrolidines; D011941:Receptors, Adrenergic; D011957:Receptors, Opioid; D011985:Receptors, Serotonin; D003000:Clonidine; D007608:Kainic Acid