Specific effects of alpha-D,L-aminoadipic acid on synaptic transmission in frog spinal cord.
The sucrose gap technique was employed to investigate both synaptic and amino acid evoked responses from motoneurones or primary afferents of frog spinal cord. alpha-D,L-Aminoadipic acid (alpha-D,L-AAD) selectively antagonized responses to acidic amino acids, especially aspartate. The drug was most effective in antagonizing the polysynaptic components of synaptic potentials evoked by dorsal root or lateral column stimulation but had little effect on their monosynaptic components. The ventral root dorsal root potential which is thought to be mediated by a pathway that does not involve acidic amino acids was insensitive to alpha-D,L-AAD. These data, which were confirmed by intracellular recording from motoneurones, provided further evidence for the role of acidic amino acids in polysynaptic pathways in frog spinal cord.
D015074:2-Aminoadipic Acid / Q000494:pharmacology*; D000596:Amino Acids / Q000494:pharmacology; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D009046:Motor Neurons / Q000187:drug effects; D011894:Rana pipiens; D013116:Spinal Cord / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D000596:Amino Acids; D000600:Amino Acids, Dicarboxylic; D015074:2-Aminoadipic Acid