Incidence of pulmonary metastases for various neoplasms in BALB/cStCrlfC3H/Nctr female fed N-2-fluorenylacetamide.
Incidence of pulmonary metastases for a variety of neoplasms was studied in many inbred BALB/cStCrlfC3H/Nctr female mice fed 2-fluorenylacetamide. Bladder carcinomas and hepatocellular carcinomas appeared to be the only neoplasms that were dose related. Hepatocellular carcinomas metastasized to the lungs at an incidence of 4.8%, and bladder carcinomas metastasized at an incidence of 0.28%. Osteogenic sarcomas metastasized to the lungs at an incidence of 46.2%; renal adenocarcinomas, at 20%; fibrosarcomas, at 16.7%; mammary adenocarcinomas, at 9.8%; and myoepitheliomas, at 10.5%. Other malignant neoplasms, including leiomyosarcomas, granulosa cells tumors, adrenocortical carcinomas, angiosarcomas, squamous cell carcinomas, and harderian gland tumors, metastasized at an incidence of less than 5%.
D015073:2-Acetylaminofluorene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002273:Carcinogens; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009208:Myoepithelioma / Q000139:chemically induced / Q000473:pathology; D009369:Neoplasms / Q000139:chemically induced* / Q000473:pathology; D012516:Osteosarcoma / Q000139:chemically induced / Q000473:pathology; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000473:pathology
D002273:Carcinogens; D015073:2-Acetylaminofluorene