Interpreting power spectra from nonstationary membrane current fluctuations.
It is often desirable to characterize membrane current fluctuations from ionic channels under conditions in which the mean current and the variance of the fluctuations change with time. A simple theory is developed that relates the power spectrum to the channel characteristics under such nonstationary conditions, assuming that the mean current time-course has been removed from the fluctuation records. Strategies for removing the mean time-course are discussed, the spectra are calculated from simulated channel fluctuations for comparison with the theory.
D003201:Computers; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008433:Mathematics; D008564:Membrane Potentials; D008566:Membranes / Q000502:physiology*; D008954:Models, Biological
D007473:Ion Channels