Selective neurotoxic action of capsaicin on glomerular C-type terminals in rat substantia gelatinosa.
This study demonstrates that capsaicin exerts a selective neurotoxic action to induce degeneration of glomerular C-type nerve terminals in adult rats. Since the C terminals may be essential components of the circuitry for modulation of pain, it is suggested that capsaicin induced analgesia is the result of this neurotoxic action.
D000818:Animals; D002211:Capsaicin / Q000633:toxicity*; D005231:Fatty Acids, Unsaturated / Q000633:toxicity*; D005727:Ganglia, Spinal / Q000187:drug effects; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects*; D013376:Substantia Gelatinosa / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D005231:Fatty Acids, Unsaturated; D002211:Capsaicin