title: Canine adenovirus-induced ocular lesions in the Afghan hound.
abstract: A series of referred cases of CAV-1-induced ocular disease suggested increased susceptibility of the Afghan Hound. Of a litter of Afghan Hound puppies inoculated with a commercial vaccine containing attenuated CAV-1, three developed corneal edema and the litter as a whole showed marked febrile and serological responses to the virus. Under experimental conditions Afghan Hounds inoculated with CAV-1 at two levels of attenuation showed more profound clinical responses than Beagles receiving similar inocula. An enhanced generalized susceptibility to infection is suggested as a possible explanation for the greater incidence of CAC-1-induced ocular lesions in this breed.
mesh_terms: D000256:Adenoviridae / Q000276:immunology; D000257:Adenoviridae Infections / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001947:Breeding; D003318:Corneal Opacity / Q000473:pathology / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005123:Eye / Q000473:pathology; D005128:Eye Diseases / Q000662:veterinary*; D007500:Iritis / Q000473:pathology / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral