Absence of an association between past infection with hepatitis A virus and primary hepatocellular carcinoma.
Serum samples from 77 caucasians of Greek origin with primary hepatocellular carcinoma (PHC) and 77 age- and sex-matched controls were tested for antibody to the hepatitis A virus (anti-HAV). Anti-HAV was detected in 63 patients with PHC (82%) and in 70 controls (91%). These data suggest that past infection with hepatitis A virus is not related to the development of PHC, in marked contrast to the strong association between PHC and HBV.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000276:immunology; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000276:immunology; D006509:Hepatitis B / Q000150:complications / Q000276:immunology; D006801:Humans; D007158:Immunologic Techniques; D008113:Liver Neoplasms / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral