Structure of gap junctions in cultures of normal and neoplastic bladder epithelial cells.
Normal rat urinary bladder epithelial cells contain small subunit (PF-1) and large subunit (PF-2) gap junctions, whereas carcinoma cells only contain PF-1 gap junctions. The absence of PF-2 gap junctions, which are composed of larger connections with slightly larger ionic channels, may contribute to altered metabolic coupling between urinary bladder carcinoma cells.
D000818:Animals; D004848:Epithelium / Q000648:ultrastructure; D005200:FANFT; D007365:Intercellular Junctions / Q000648:ultrastructure*; D007473:Ion Channels / Q000648:ultrastructure; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental / Q000648:ultrastructure; D051381:Rats; D001743:Urinary Bladder / Q000648:ultrastructure*; D001749:Urinary Bladder Neoplasms / Q000648:ultrastructure*
D007473:Ion Channels; D005200:FANFT