[Effect of pharmacological agents on the development of heat stroke].
The effect of drugs on the development of excitation, thermal shock and animal survival was studied. The alpha-adrenoblockers aminazin and phentolamine, the sympatholytic dopegit, and antidepressants sapilent, teperin and nuredal prolonged the time of the onset of excitation and thermal shock, and prevented the animals' death in 50-87% of experiments. It is assumed that the sympathetic nervous system plays the leading role in the development of thermal shock. Aminazin, dopegit, sapilent, teperin and nuredal can be recommended as protectors on body exposure to high temperatures.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004780:Environment, Controlled; D005260:Female; D006359:Heat Exhaustion / Q000188:drug therapy*; D008297:Male; D010276:Parasympatholytics / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000627:therapeutic use; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D013565:Sympatholytics / Q000627:therapeutic use; D013566:Sympathomimetics / Q000627:therapeutic use; D013997:Time Factors
D010276:Parasympatholytics; D011619:Psychotropic Drugs; D011942:Receptors, Adrenergic, alpha; D013565:Sympatholytics; D013566:Sympathomimetics
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