Induction of 2',3'-cyclic nucleotide 3'-phosphohydrolase and morphological alterations in C6 glioma cells by dexamethasone, (3-butoxy-4-methoxybenzyl)-2-imidazolinone and prostaglandin E1.
Dexamethasone, RO20-1724 and prostaglandin E1 all induced morphological alterations and increased the glial specific enzyme 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) in rat C6 glioma cells in culture. Morphological alterations consisted mainly in the development of astrocytelike changes. Increases in dexamethasone-induced CNP activity was time dependent. Dexamethasone reduced cell growth rate, depending on the concentration employed.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000096:biosynthesis*; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division; D002460:Cell Line; D003907:Dexamethasone / Q000494:pharmacology*; D004790:Enzyme Induction; D005910:Glioma; D007093:Imidazoles / Q000494:pharmacology*; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D010727:Phosphoric Diester Hydrolases / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats
D007093:Imidazoles; D011458:Prostaglandins E; D012368:4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; D003907:Dexamethasone; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases