title: Disposition of pipecurium bromide in rats.
abstract: The disposition of 2 beta,16 beta-bis-(4'-dimethyl-1'-piperazino)-3 alpha,17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, RGH-1106, Arduan), a new neuromuscular blocking agent, was studied in rats by using labelled substance. Radioactive substance is rapidly taken up by the liver and to a lesser extent by the kidneys. The compound is retained by the liver for a longer period of time, some 6% of the administered 14C-activity can be recovered from the liver 21 days after the i.v. administration of the drug. Only traces of radioactivity could be detected in the brain and less than 0.1% of the dose could be found in the foetus. Binding to rat plasma protein is of about 30%. The compound seems to be eliminated with urine, the excreted amount being 37.55 +/- 11.91% and 45.44 +/- 17.29% during 24 and 48 h, respectively. No radioactivity was detected in the expired air.
mesh_terms: D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D000732:Androstanols / Q000378:metabolism*; D000818:Animals; D002850:Chromatography, Gel; D003956:Dialysis; D005260:Female; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000378:metabolism* / Q000652:urine; D017300:Pipecuronium; D010879:Piperazines / Q000378:metabolism* / Q000652:urine; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011485:Protein Binding; D051381:Rats; D014018:Tissue Distribution
chemical_list: D000732:Androstanols; D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol