Serum levels of mecillinam in patients with severely impaired renal function.
12 patients with severe renal insufficiency were treated for urinary tract infection with 400 mg of mecillinam intravenously every 6 h. High serum concentrations of mecillinam were found 6 h after the first morning dose on day 2 and day 5 of the treatment period (mean values 11.4 and 14.5 microgram/ml respectively), and a serum half-life of 334 min. In spite of reduced elimination of the drug, a nearly steady state was achieved within the first few days of treatment. Side effects were not observed.
D000560:Amdinocillin / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D010397:Penicillanic Acid / Q000097:blood*; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
D010397:Penicillanic Acid; D000560:Amdinocillin