The in vitro metabolism of 2,2',4,4',5,5'-hexabromobiphenyl.
Radiolabelled 2,2',4,4',5,5'-hexabromobiphenyl was metabolized in vitro by rat liver microsomal enzymes to give more polar ether soluble lipophilic metabolites, trichloroacetic acid soluble conjugates and a macromolecular adduct fraction. The rates of formation of the three metabolic fractions were significantly enhanced using Firemaster BP-6 and 2,2',4,4',5,5'-hexabromobiphenyl induced microsomal enzymes. Comparative metabolic studies with the 4-brombiphenyl substrate showed that the lower brominated biphenyl substrate was more readily metabolized and the rate of metabolism was enhanced only with the Firemaster BP-6 induced microsomal enzymes and not the 2,2', 4,4',5,5'-hexabromobiphenyl induced enzyme system.
D000818:Animals; D001713:Biphenyl Compounds / Q000378:metabolism*; D005411:Flame Retardants / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D011075:Polybrominated Biphenyls / Q000378:metabolism*; D051381:Rats
D001713:Biphenyl Compounds; D005411:Flame Retardants; D011075:Polybrominated Biphenyls; D009249:NADP; C018566:2,4,5,2',4',5'-hexabromobiphenyl; D006899:Mixed Function Oxygenases