[Pharmacological effects of veralipride on the mammary gland of female rats: a complementary study (author's transl)].
Administration of 2 mg/kg/day of veralipride to intact female rats for 3 weeks provokes mammary gland development and, in some animals, the onset of secretory activity. These modifications do not appear after veralipride administration, under the same conditions, to castrated female rats. In castrated female rats previously conditioned by estradiol benzoate administration, some development of several acinous islets is observed in about half of the animals treated or not with veralipride. This suggests the development of a sensitivity of the mammary gland to the action of pituitary hormones, the secretion of which is stimulated by either castration or veralipride. It would seem that the absence of corpora lutea secretions prevented as great a mammary gland development as that observed in intact animals treated with veralipride.
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D010907:Pituitary Hormones / Q000378:metabolism; D051381:Rats; D013469:Sulpiride / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D010907:Pituitary Hormones; D004958:Estradiol; D013469:Sulpiride; C027429:veralipride
Etude pharmacologique complémentaire des effets du véralipride sur la glande mammaire de la ratte castrée.