Age-related differences in the urinary excretion of prostaglandin F2 alpha catabolites in the rat.
Tritium-labeled PGF2 alpha was administered i.v. into rats of varying ages (2, 4, 6 weeks and adult). Urine was collected and assayed for radioactive products by thin-layer-chromatography. Results showed a distinctly different urinary profile between the 2-week-old and the adult rat. While the urinary pattern from the 2-week-old rat gave a single less polar product than PGF2 alpha, the pattern from the adult rat gave products more polar than PGF2 alpha. Urine from the 4- and 6-week-old rats gave a mixture of these types of products. These results indicate that some prostaglandin catabolic pathway (likely the omega-oxidative system) is activated in vivo within the 4-6 week postnatal period in the rat.
D011452:15-Oxoprostaglandin 13-Reductase / Q000378:metabolism; D000367:Age Factors; D000818:Animals; D006911:Hydroxyprostaglandin Dehydrogenases / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011460:Prostaglandins F / Q000378:metabolism / Q000652:urine*; D051381:Rats
D011460:Prostaglandins F; D006911:Hydroxyprostaglandin Dehydrogenases; D011452:15-Oxoprostaglandin 13-Reductase