5'-Nucleotide phosphodiesterase isozyme-V in health, in cancer, and in viral hepatitis.
An abnormal, fast-moving 5'-nucleotide phosphodiesterase isozyme was found in 90.0% of 20 Malaysian patients with primary hepatoma and in 23.5% of 391 Malaysian patients with various malignant diseases; it was also discovered in 42.9% of 14 Malaysian and American patients with clinically active hepatitis B infection; in 16.7% of 18 healthy American blood bank donors who were positive for hepatitis B surface antigen (HBsAg); in 13.9% of 287 healthy Malaysian blood bank donors, some positive for HBsAg; and in none of 160 healthy American donors who were negative for HBsAg. A correlation of this abnormal isozyme with hepatoma and with infectious hepatitis B is clearly evident.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000201:enzymology; D005260:Female; D006509:Hepatitis B / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008113:Liver Neoplasms / Q000201:enzymology; D008296:Malaysia; D008297:Male; D009369:Neoplasms / Q000201:enzymology*; D009711:Nucleotides; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases / Q000097:blood*; D014481:United States
D007527:Isoenzymes; D009711:Nucleotides; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I