Ultrastructural study of tissue and peripheral blood neutrophils in human renal allograft recipients. A clinicopathological description of an unusual abnormality discovered in three cases.
This report describes an unusual striking ultrastructural abnormality of neutrophils in three human renal allograft recipients. The abnormal neutrophils showed the presence of numerous elongated nuclear and cytoplasmic inclusions measuring up to 1.6 by 0.1 mu in greatest dimensions. Although the definite nature and functional significance of these inclusions are unknown, we suggest that they may represent an acquired neutrophil disorder. The three patients had serious infectious complications.
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D002479:Inclusion Bodies / Q000648:ultrastructure; D016030:Kidney Transplantation; D008297:Male; D009504:Neutrophils / Q000648:ultrastructure*; D011241:Prednisone / Q000627:therapeutic use; D014184:Transplantation, Homologous; D014552:Urinary Tract Infections / Q000150:complications
D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone