Effects of neuronal activity on kainic acid neurotoxicity in the ventral cochlear nucleus.
Kainic acid was injected into the brain stem of adult guinea pigs, and the animals were either placed in a sound reducing-chamber or stimulated with 90 dB noise. The pattern and rate of kainic acid-induced degeneration in the anteroventral cochlear nucleus (AVCN) of sound-deprived animals was similar to that in animals exposed to ambient noise [2]. The amount of degeneration was greatly increased in animals stimulated with 90 dB noise. Therefore, although decreased activity in primary auditory fibers does not protect neurons in the AVCN from kainate-induced neurotoxicity, increased auditory stimulation augments the effects of kainic acid in the cochlear nucleus.
D000161:Acoustic Stimulation; D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D003056:Cochlear Nerve / Q000187:drug effects*; D006168:Guinea Pigs; D007608:Kainic Acid / Q000633:toxicity*; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D011759:Pyrrolidines / Q000633:toxicity*; D009435:Synaptic Transmission / Q000187:drug effects
D011759:Pyrrolidines; D007608:Kainic Acid