Release of disaggregatory prostanoids into circulation by nicotinic alcohol, nicotinic acid and nicotinamide.
Nicotinic alcohol, nicotinic acid and nicotinamide caused disaggregation of platelet clumps formed on collagen strip superfused with blood of anaesthetized cats. This effect was completely blocked by pretreatment of cats with 50 mg/kg of acetyl salicylic acid. Disaggregatory substance formed in cat's blood disappeared when blood had been passed through silicone coil warmed to 37 degrees C for 15 min. None of the tested substances had any disaggregatory activity when applied directly on collagen strip. It is postulated that the effect of nicotinic acid derivatives is mediated by prostacyclin which they release.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002415:Cats; D003094:Collagen / Q000494:pharmacology; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D008297:Male; D009525:Niacin / Q000494:pharmacology*; D009536:Niacinamide / Q000494:pharmacology*; D009540:Nicotinyl Alcohol / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*
D011725:Pyridines; D009536:Niacinamide; D009525:Niacin; D003094:Collagen; D009540:Nicotinyl Alcohol; D011464:Epoprostenol; D001241:Aspirin