title: [State of the pituitary-adrenal system of cosmonauts after orbital flights of different duration].
abstract: In order to assess the hypophyseal-adrenal system and glucocorticoid activity, excretion of total 17-hydroxycorticosteroids (17-HOCS) was measured before and at R + 1 day after a standard water load (20 ml/kg). Twenty-six cosmonauts were examined after flights of 2--140 days. Although the cosmonauts spent different time in weightlessness, the content and rate of glucocorticoid excretion in the urine during postflight water loads was 1.5--2 times higher than during preflight loads. This increased excretion of 17-HOCS was associated with their decreased reabsorption and/or increased glomerular secretion. The latter may be a manifestation of extrarenal action of ACTH due to its hyperproduction immediately postflight.
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000652:urine*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D004231:Diuresis; D006801:Humans; D010902:Pituitary Gland / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000502:physiology*; D013026:Space Flight; D013997:Time Factors; D014667:Vasopressins / Q000378:metabolism; D014893:Weightlessness
chemical_list: D015065:17-Hydroxycorticosteroids; D014667:Vasopressins; D000324:Adrenocorticotropic Hormone
vernacular_title: K voprosu o sostoianii gipofizarno-adrenalovoĭ sistemy u kosmonavtov posle orbital'nykh poletov razlichnoĭ prodolzhitel'nosti.