Cytotoxic activities of monoclonal antibodies against the envelope proteins of murine leukemia virus.
Monoclonal antibodies against the envelope proteins [gp70 and p15(E)] of murine leukemia virus react with the cell surface of virus-infected cells. The specificity and potency of these antibodies exceed those observed with conventional polyvalent antisera. In cytotoxic assays, certain of the monoclonal anti-gp70 antibodies demonstrate 1000-fold differences in their titer on leukemic and normal thymus cells.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D002460:Cell Line; D005455:Fluorescent Antibody Technique; D007106:Immune Sera; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D014777:Virus Diseases / Q000276:immunology
D000914:Antibodies, Viral; D007106:Immune Sera; D008565:Membrane Proteins