The rate of ATP synthesis by submitochondrial particles can be independent of the magnitude of the protonmotive force.
The problem of whether the rate of ATP synthesis is proportional to the magnitude of the protonmotive force has been studied in submitochondrial particles. It was found that the rate of ATP synthesis can decrease at constant protonmotive force and is more closely related to the rate of substrate oxidation.
D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D002417:Cattle; D004563:Electrochemistry; D008314:Malonates / Q000494:pharmacology; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D011522:Protons; D013367:Submitochondrial Particles / Q000187:drug effects / Q000378:metabolism*
D008314:Malonates; D011522:Protons; D000255:Adenosine Triphosphate