Hypothalamic sarcoidosis and hypopituitarism.
4 patients with presumed pituitary hypothalamic sarcoidosis are described. 3 had histological diagnoses compatible with sarcoidosis and in the other this diagnosis was strongly suspected from chest X-rays. 2 patients presented with diabetes insipidus. ACTH reserve was diminished in 3 out of 4 and growth hormone reserve was diminished in the 3 who were tested. All 4 patients developed secondary amenorrhea. 3 patients had hypothalamic hypothyroidism. Prolactin dynamics were intact. Tomograms of the sella turcica in all 4 and computerized tomography of the hypothalamic area in 2 patients failed to reveal any abnormality.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000293:Adolescent; D000324:Adrenocorticotropic Hormone; D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006914:Hydroxysteroids / Q000652:urine; D007003:Hypoglycemia / Q000139:chemically induced; D007018:Hypopituitarism / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin; D007986:Luteinizing Hormone / Q000097:blood; D008797:Metyrapone; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012507:Sarcoidosis / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D014667:Vasopressins / Q000097:blood
D015065:17-Hydroxycorticosteroids; D006914:Hydroxysteroids; D007328:Insulin; D014667:Vasopressins; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone; D008797:Metyrapone