The effect of gossypol on ATPase activity of the kidney.
The results of the present study have shown no change in the activity of ATPase of the renal cortex of rats administered gossypol for half a year. The Na+, K+-ATPase activity of the cellular membrane of renal cortex of guinea pigs fed with gossypol for 5 or 9 weeks is significantly altered. It seems possible to diminish or to delay the inhibition by allowing the guinea pigs a potassium-rich diet ad libitum. In vitro, gossypol inhibits significantly the activity of ATPase of the brain and the kidney of rats and guinea pigs uncompetitively. However, the inhibition of the ATPase of human fetus kidney is of a mixed type.
D000818:Animals; D001921:Brain / Q000201:enzymology; D005260:Female; D005333:Fetus / Q000201:enzymology; D006072:Gossypol / Q000494:pharmacology*; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D011188:Potassium / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D000254:Sodium-Potassium-Exchanging ATPase; D006072:Gossypol; D011188:Potassium