Mallory body formation in hepatic nodules of mice ingesting dieldrin.
Mallory bodies (MBs) were observed in hepatic nodules induced by long-term administration of a diet containing 10 p.p.m. of dieldrin to C57BL/6 mice. MBs were first detected after 46 weeks and were seen in 26 of 41 mice which developed hepatic nodules. The MBs were limited to the nodules in 25 mice. Twenty-one of the nodules were carcinomas and 20 of those contained MBs. Our observations suggest that MBs may be a marker for neoplastic transformation and may prove useful in experimental studies of carcinogenesis.
D000818:Animals; D003599:Cytoskeleton; D004026:Dieldrin; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008099:Liver / Q000648:ultrastructure*; D008103:Liver Cirrhosis / Q000209:etiology*; D008113:Liver Neoplasms / Q000175:diagnosis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D004026:Dieldrin