[Physico-chemical principles for discrimination of sodium and potassium ions by membrane Na pumps. I. Effect of organic compounds on the ionic specificity of Na, K-ATPase].
Effects of some organic compounds of different hydrophobicity on the structure and ion specificity of the sodium-potassium adenosine triphosphatase (Na,K-ATPase) membrane preparation were studied. Inhibition abilities of these compounds correlate well with their lipophilic properties. High hydrophobic compounds change mainly the enzyme activation by potassium ions and the spin label mobilities in hydrophobic regions of the membrane preparation. Polar species, in contrast, influence the enzyme activation by sodium ions and the surface polar properties of the membrane preparation. It is supposed, that the Na,K-ATPase activations by potassium and sodium ions are correspondingly related to hydrophobic regions of the lipoprotein enzyme complex and to the polar regions stabilized by hydrogen bonds.
D000096:Acetone / Q000494:pharmacology; D000438:Alcohols / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004126:Dimethylformamide / Q000494:pharmacology; D004146:Dioxanes / Q000494:pharmacology; D004789:Enzyme Activation; D005990:Glycerol / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014508:Urea / Q000494:pharmacology
D000438:Alcohols; D004146:Dioxanes; D000096:Acetone; D010042:Ouabain; D004126:Dimethylformamide; D014508:Urea; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D005990:Glycerol; D011188:Potassium; D004121:Dimethyl Sulfoxide
O fiziko-khimicheskikh printsipakh raspoznavaniia ionov natriia i kaliia Na-nasosom membran. I. Vliianie organicheskikh veshchestv na ionnuiu spetsifichnost' Na, K-ATPazy.