Analysis of the virogenes related to the rhesus monkey endogenous type C retrovirus in monkeys and apes.
Molecular hybridization studies were carried out by using a [3H]complementary DNA (cDNA) probe to compare the endogenous type C retrovirus of rhesus monkeys (MMC-1) with other known retroviruses and related sequences in various primate DNAs. The genomic RNA of the endogenous type C retrovirus of stumptail monkeys (MAC-1) was found to be highly related to the MMC-1 cDNA probe, whereas the other retroviral RNAs tested showed no homology. Related sequences were found in Old World monkey DNAs and to a lesser extent in gorilla dn chimpanzee DNAs. No homology was detected between MMC-1 cDNA and DNA of gibbon, orangutan, or human origin. Restriction endonuclease analysis of genomic DNA indicated that many of the several hundred sequences related to MMC-1 in rhesus monkey DNA differed from that integrated into DNA of infected canine cells. Gorilla and chimpanzee DNAs contained a specific restriction endonuclease fragment of the MMC-1 genome.
D000818:Animals; D001483:Base Sequence; D004285:Dogs; D005814:Genes, Viral; D000882:Haplorhini / Q000235:genetics*; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008251:Macaca / Q000235:genetics*; D008253:Macaca mulatta / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011995:Recombination, Genetic; D012190:Retroviridae / Q000235:genetics*