Two types of potassium channels in the PC12 cell line.
Activation of K+ channels in the PC12 cell line was studied by comparing 86Rb+ efflux under depolarizing and non-depolarizing conditions. Evidence for both Ca2+-dependent and voltage-dependent K+ channels was obtained by studying depolarization-induced 86Rb+ efflux in solutions of varying Ca2+ concentration and in the presence of K+ and Ca2+ channel blocking agents.
D000310:Adrenal Gland Neoplasms / Q000378:metabolism; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008345:Manganese / Q000494:pharmacology; D010673:Pheochromocytoma / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D012413:Rubidium / Q000378:metabolism
D007473:Ion Channels; D008345:Manganese; D012413:Rubidium; D011188:Potassium; D002118:Calcium