title: The differential development of mitochondrial cytochrome P-450 and the respiratory cytochromes in rat ovary.
abstract: The cytochrome concentrations in ovarian mitochondria were determined in immature and superovulated rats. The respiratory cytochromes (b, c + c1 and a + a3) were found to increase approximately 3-fold during the transition from immature follicle to active steroid-producing corpus luteum. At the same time, mitochondrial cytochrome P-450 exhibited a 10-fold increase in concentration, reflecting the ability of the gland to synthesize steroids. This different rate of synthesis of mitochondrial cytochrome P-450 and respiratory cytochromes may be regarded as a biochemical differentiation step necessary for the granulosa cells to develop steroidogenic competence.
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003580:Cytochromes / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D007700:Kinetics; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism*; D010060:Ovulation; D051381:Rats; D013480:Superovulation
chemical_list: D003580:Cytochromes; D003577:Cytochrome P-450 Enzyme System; D003576:Electron Transport Complex IV