Immunological properties of beta-lactamases that hydrolyze cefuroxime and cefotaxime.
Antiserum against purified beta-lactamase from Proteus vulgaris GN7919 cross-reacted with beta-lactamases produced by strains of Pseudomonas cepacia in a neutralization test. Anti-P. cepacia beta-lactamase serum, however, did not show any cross-reactions with P. vulgaris beta-lactamases. Each of these enzymes can hydrolyze cefuroxime and cefotaxime.
D000818:Animals; D001419:Bacteria / Q000201:enzymology*; D002439:Cefotaxime / Q000378:metabolism*; D002444:Cefuroxime / Q000378:metabolism*; D002510:Cephalosporinase / Q000276:immunology*; D002511:Cephalosporins / Q000378:metabolism*; D003429:Cross Reactions; D006868:Hydrolysis; D011817:Rabbits / Q000276:immunology; D001618:beta-Lactamases / Q000276:immunology*
D002511:Cephalosporins; D002510:Cephalosporinase; D001618:beta-Lactamases; D002439:Cefotaxime; D002444:Cefuroxime