Proliferation rate--drug sensitivity relation in clones isolated from heterogeneic tumor cell population.
Four separate cell clones were isolated from parental rat RBB/R cell line. Sensitivity of clones to 3-oxauracil varied, and was dependent on the proliferation rate of particular clone. Colony formation method was more appropriate than 3H-thymidine incorporation for determination of post-treatment surviving cells.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001358:Avian Sarcoma Viruses; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002999:Clone Cells / Q000187:drug effects; D010078:Oxazines; D051381:Rats; D001357:Sarcoma, Avian / Q000473:pathology*; D014498:Uracil / Q000031:analogs & derivatives / Q000494:pharmacology
D000970:Antineoplastic Agents; D010078:Oxazines; C015409:3-oxauracil; D014498:Uracil