[Isolation and physicochemical study of the components of the new antibacterial antibiotic 2562].
An antibacterial antibiotic complex consisting of 2 components designated as 2562 A and 2562 B is produced by Streptomyces griseovarabilis. The antibiotic was isolated from the mycelium and purified chromatographically on a column with aqueous silicic acid. The study of the components showed that component 2562 A was chlorbiocin, while component 2562 B differed from the known antibiotics of this group. Physicochemical assays demonstrated that component 2562 B differed from chlorbiocin by the absence of the methyl group in pyrrol, which is probably attached to sugar at beta-position. It was found that component 2562 B is a new representative of the antibiotic cumero-glycoside group.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D004578:Electron Spin Resonance Spectroscopy; D006868:Hydrolysis; D009675:Novobiocin / Q000031:analogs & derivatives; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D009675:Novobiocin; C026128:antibiotic 2562
Poluchenie i fiziko-khimicheskoe izuchenie komponentov novogo antibakterial'nogo antibiotika 2562.