title: Non-traumatic removal of the nail and simultaneous treatment of onychomycosis.
abstract: There are no doubt a great many therapeutic recommendations for the treatment of onychomycoses. However, as so often, it soon becomes evident that the number of therapeutic regimens appear to indicate a wide range of therapeutic possibilities, but the rates of cure actually achieved are in complete contrast to these. The prerequisite for treatment is the identification of the causative fungi on direct microscopic examination and in culture to avoid the use of antifungals in changes of the nails other than onychomycoses. Another very important prerequisite for systematic treatment is the removal of as much fungus-infected nail material as possible, or else bioavailability at the site of infection cannot, or only hardly, be guaranteed. In our investigations into the treatment of onychomycosis we studied the use of bifonazole (1%)-urea ointment and the therapeutic possibilities in connection with its application.
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D009262:Nails / Q000187:drug effects*; D014009:Onychomycosis / Q000188:drug therapy*; D014508:Urea / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D014508:Urea; C036596:bifonazole