title: 2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research.
abstract: Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D008027:Light; D009337:Necturus; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012160:Retina / Q000166:cytology / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D014785:Vision, Ocular / Q000187:drug effects
chemical_list: D000613:Aminobutyrates; D009943:Organophosphorus Compounds; D017981:Receptors, Neurotransmitter; C012729:2-amino-4-phosphonobutyric acid