[A common pool of adenylate cyclase for different types of afferent receptors].
The authors investigate whether adenylate cyclase, that is a component of different receptors, i.e. the beta-adrenergic and H2-Histaminic ones of the heart, either plays a specific role for the activation of each receptor of forms the same pool for two types of receptors. On the mechanogram of guinea pig ventricle, stimulated by electric stimuli, an analysis of interferences among isoprenaline, propranolol, histamine and noradrenaline shows that isoprenaline inhibits histamine; in presence of propranolol the isoprenaline doesn't block histamine. Therefore the AA. conclude that adenylate cyclase is common to both receptors.
D000262:Adenylyl Cyclases / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists; D007545:Isoproterenol / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology*
D006633:Histamine Antagonists; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D006632:Histamine; D011433:Propranolol; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine
Su una riserva comune di adenilciclasi alla quale afferiscono recettori differenti.