Sputum cytology of a metastatic postradiation sarcoma (malignant fibrous histiocytoma).
A female patient who died of apparent postradiation sarcoma in the inguinal region after irradiating a metastatic squamous cell carcinoma of the same site was reported. For approximately 20 months, the patient had received a total of 6,600 and 9,600 Roentgen to the right para-aortic and inguinal areas, respectively. About 10 years later, she developed a sarcoma, namely a malignant fibrous histiocytoma. Sputum cytology demonstrated numerous giant cells with bizarre nuclei; subsequent chest films also presented apparent metastatic tumor shadows. The cellular characteristics and also rather low incidence of detection of nonepithelial malignant tumor by sputum cytology were briefly discussed, and ways of enhancing cytodiagnostic accuracy were proposed.
D000328:Adult; D001859:Bone Neoplasms / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D003581:Cytodiagnosis; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects; D013183:Sputum / Q000166:cytology*