[Demonstration of Epstein-Barr virus genome in european Burkitt lymphoma (author's transl)].
A 6-year-old European boy with a tumour in the head and neck region died 86 days after the first occurrence of symptoms despite chemo- and radiotherapy. An epipharyngeal biopsy at the beginning of the disease and a cytological investigation of biopsy and autopsy material showed non-Hodgkin lymphoma with a high degree of malignancy of the Burkitt type. High antibody titres against Epstein-Barr virus (EBV)-specific virus capsid antigen, nuclear antigen and the R component of the EBV-early-antigen-complex as well as the approximately 27 EBV genome equivalents per tumour cell, demonstrated by DNA-DNA hybridisation, characterised the tumour as true Burkitt lymphoma which is observed extremely seldom outside Africa.
D000956:Antigens, Viral / Q000032:analysis; D002051:Burkitt Lymphoma / Q000032:analysis* / Q000473:pathology; D002648:Child; D005814:Genes, Viral; D004854:Herpesvirus 4, Human; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000032:analysis* / Q000473:pathology
D000956:Antigens, Viral
Epstein-Barr-Virus-Genomnachweis in einem europäischen Burkitt-Lymphom.