A postsynaptic alpha 2-receptor: the alpha-adrenergic receptor of hamster white fat cells.
The effects of selected alpha-agonists and alpha-antagonists on theophylline-induces lipolysis were investigate in isolated hamster white fat cells, alpha 2-Agonists (tramazoline, clonidine) inhibited theophylline-induced lipolysis while in alpha 1-agonist (methoxamine) was without any effect. The inhibitory effect of alpha 2-agonists was suppressed by yohimbine (alpha 2-antagonist), whereas alpha 1-antagonists were inefficient. This result implies that the alpha-adrenergic receptor of hamster fat cells is of the alpha 2-type, although postsynaptically.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D008053:Lipid Mobilization / Q000187:drug effects*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D013806:Theophylline