title: Timolol treatment in the irritable bowel syndrome.
abstract: The overall effect of the beta-blocker timolol maleate was not significantly different from placebo in patients with the irritable bowel syndrome on a high fibre diet. However, all 3 symptom-free patients were on timolol maleate. If beta-blockers have a major role to play in the treatment of the irritable bowel syndrome it must be through a central rather than a peripheral effect.
mesh_terms: D002986:Clinical Trials as Topic; D003109:Colonic Diseases, Functional / Q000178:diet therapy / Q000188:drug therapy*; D004043:Dietary Fiber / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011412:Propanolamines / Q000627:therapeutic use*; D011446:Prospective Studies; D013999:Timolol / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004043:Dietary Fiber; D011412:Propanolamines; D013999:Timolol