The mechanical and biochemical effects of pentoxifylline on the perfused rat heart.
Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010431:Pentoxifylline / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013805:Theobromine / Q000031:analogs & derivatives*
D012110:Reserpine; D000242:Cyclic AMP; D011494:Protein Kinases; D006152:Cyclic GMP; D013805:Theobromine; D010431:Pentoxifylline