Effects of Pexid on liver cell cultures. Ultrastructural and histoenzymological studies.
The effects of different doses of Pexid on cultured liver cells have been studied by ultrastructural and histoenzymological techniques. Two types of abnormal lysosomal inclusions were seen: clear matrix inclusions with either homogeneous or tiny lamellar structures, and dark matrix inclusions with clear vacuoles and either random or myelin-like lamellar structures. These patterns correspond to storage of triglycerides, phospholipids and gangliosides, either singly or together.
D002478:Cells, Cultured; D005732:Gangliosides / Q000032:analysis; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008854:Microscopy, Electron; D010480:Perhexiline / Q000031:analogs & derivatives / Q000633:toxicity*; D010880:Piperidines / Q000633:toxicity*
D005732:Gangliosides; D010880:Piperidines; D006003:Glycogen; C023470:perhexiline maleate; D010480:Perhexiline