[New method of lysophospholipid incorporation into biological membranes. Effect of lysophosphatidylcholine on the activity of membrane-bound enzymes].
The incorporation of lysophosphatidylcholine into biological membranes and its effect on some membrane-bound enzymes of mitochondria and microsomes from rat liver and hepatoma were studied. It was shown that in the presence of lipid-exchange proteins of the liver a far greater amount of lysophosphatidylcholine is incorporated into the membranes than in the-iv absence. The increase of the lysophosphatidylcholine content in the membranes has no effect on the activity of mitochondrial monoamine oxidase, inhibits the activity of microsomal cytochrome P-450 and activates glucose-6-phosphatase.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism*; D007700:Kinetics; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D008244:Lysophosphatidylcholines / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats
D008244:Lysophosphatidylcholines; D008563:Membrane Lipids; D003577:Cytochrome P-450 Enzyme System; D008995:Monoamine Oxidase; D005952:Glucose-6-Phosphatase
Novyĭ sposob vvedeniia lizofosfolipidov v sostav biologicheskikh membran. Vliianie lizofosfatidilkholina na aktivnost' membranosviazannykh fermentov.