[Immunological characterization of unusual plasmacytic tumor cells in a disseminated non-Hodgkin's lymphoma].
Using monoclonal antibodies and heterosera, tumor cells from a disseminated neoplasia were characterized that could not be classified by conventional histology. The large, sometimes multinucleated tumor cells expressed Ia antigens and were positive for immunoglobulins both at the surface and intracellularly (mu, delta, kappa). This tumor was infiltrated by a large number of T cells that comprised about two thirds of the total cell number eluted from the tumor and predominantly were of the suppressor/cytotoxic phenotype. This tumor can be defined as a lymphoma of the B cell lineage with an unusual differentiation exhibiting both Ia antigens and surface immunoglobulins in addition to plasmacytoid markers.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008223:Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014750:Vincristine / Q000008:administration & dosage
D000949:Histocompatibility Antigens Class II; D007136:Immunoglobulins; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
Immunologische Charakterisierung ungewöhnlicher plasmazellulärer Tumorzellen eines multilokulären Non-Hodgkin-Lymphoms.