beta-Endorphin and beta-MSH in human plasma.
The aim of this study was to establish whether or not a peptide with chromatographic and immunological properties of beta-endorphin exists in human plasma. Using direct chromatography under conditions designed to minimize generation of beta-endorphin and beta-MSH from beta-LPH, we invariably found a peptide with beta-endorphin immunoreactivity eluting in the position of beta h-endorphin on gel chromatography in samples of plasma from patients with elevated ACTH and LPH levels. beta-MSH was only found in the plasma of one patient with the ectopic ACTH syndrome.
D000182:ACTH Syndrome, Ectopic / Q000097:blood; D000224:Addison Disease / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000097:blood; D002850:Chromatography, Gel / Q000379:methods; D004723:Endorphins / Q000097:blood*; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000097:blood*; D009347:Nelson Syndrome / Q000097:blood; D008083:beta-Lipotropin / Q000097:blood
D004723:Endorphins; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin