Antagonism by chlornaltrexamine of some effects of delta 9-tetrahydrocannabinol in rats.
Chlornaltrexamine (beta-CNA) a selective, long-acting irreversible opiate antagonist inhibited the analgesia, hypothermia, hypothermia tolerance and physical dependence produced by delta 9-tetrahydrocannabinol (THC) in rats. The results suggest that there are some common features between cannabis and opiates and some actions of THC may be mediated by opioid related mechanisms in the central nervous system.
D000698:Analgesia; D000818:Animals; D013759:Dronabinol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004361:Drug Tolerance; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000031:analogs & derivatives*; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D019966:Substance-Related Disorders
D009292:Narcotic Antagonists; D009588:Nitrogen Mustard Compounds; D011957:Receptors, Opioid; D009270:Naloxone; D009271:Naltrexone; C017120:chlornaltrexamine; D009020:Morphine; D013759:Dronabinol