Lethal effect of polymyxin B sulfate in experimental Proteus rettgeri infection in mice.
The mouse model of intraperitoneal sepsis with Proteus rettgeri was used to evaluate the anti-endotoxic effect of polymyxin B sulfate. An unexpected reversal of the usual protective effect of polymyxin in experimental enterobacterial sepsis was observed in which the lethality of the infection was enhanced.
D000818:Animals; D005260:Female; D051379:Mice; D011112:Polymyxin B / Q000009:adverse effects*; D011113:Polymyxins / Q000009:adverse effects*; D011512:Proteus Infections / Q000188:drug therapy* / Q000401:mortality
D011113:Polymyxins; D011112:Polymyxin B