title: Ion pathways in proteins of the sarcoplasmic reticulum.
abstract: In summary, we have begun to characterize three different ion pathways in the sarcoplasmic reticulum. Ca2+-ionophoric activity has been traced to a 13,000-dalton CNBr fragment localized at the amino terminus of the ATPase molecule... The pathway involved in Ca2+ release can be distinguished from the pathway involved in Ca2+ uptake by its insensitivity to quercetin. An anion pathway is sensitive to DIDS and appears to be localized in the ATPase molecule
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D000252:Calcium-Transporting ATPases / Q000032:analysis / Q000037:antagonists & inhibitors / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D007425:Intracellular Membranes / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism*; D007476:Ionophores / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D011510:Proteolipids / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D007476:Ionophores; D008051:Lipid Bilayers; D008565:Membrane Proteins; D011510:Proteolipids; D011794:Quercetin; D000252:Calcium-Transporting ATPases; D002118:Calcium