[Effect of adrenaline on the ATPase activity of rat liver plasma membranes].
In vivo and in vitro adrenaline affected dissimilarly the activity of Na+, K+-, HCO3- and Mg2+-ATPases from plasmatic membranes of rat liver tissue. Inhibition of Na+, K+-ATPase and stimulation of Mg2+-ATPase activities were observed within 1, 24 and 48 hrs after subcutaneous administration of the hormone at a dose of 0.3 and 1.0 1.0 mg/kg of body weight; at the same time, HCO3- -ATPase activity was inhibited by adrenaline at a dose of 1.0 mg/kg and stimulated--at a dose of 0.3 mg/kg. After in vitro incubation of the plasmatic membranes with 5.45 10(-6)--10(-4) M of the hormone the activities of HCO3- - and Na+, K+-ATPases were inhibited but Mg2+-ATPase activity was not altered. The data obtained suggest that the ATPases, responsible for the active membrane transport of K+, Na+ and HCO3-, are highly sensitive to adrenaline.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology; D002462:Cell Membrane / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D001639:Bicarbonates; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D004837:Epinephrine
Vliianie adrenalina na aktivnost' ATF-az plazmaticheskikh membran pecheni krys.