Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances.
Kinetic analysis of the uptake of carbon-14-labeled oleate in a single-pass perfusion of rat liver and saturable and specific binding of iodine-125-labeled albumin to hepatocytes in suspension suggest the existence of a receptor for albumin on the liver cell surface. The putative receptor appears to mediate uptake of albumin-bound fatty acids by the cell and may account for the efficient hepatic extraction of many other substances tightly bound to albumin.
D000818:Animals; D001692:Biological Transport; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D009829:Oleic Acids / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*
D005227:Fatty Acids; D009829:Oleic Acids; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface; D012709:Serum Albumin