Role of 5-HT on increased permeability of blood-brain barrier under heat stress.
Exposure of young rats (9-10 wks) to chronic summer heat (36 degrees C) or acute heat (38 degrees C 4hr) increased the BBB permeability to Evans blue albumin complex (MW 68,000) and 131I-sodium (MW 154) in different brain regions which correlated well with the increased level of 5-HT in plasma and brain. This increased permeability of BBB and the increased 5-HT level were prevented by pretreatment with p-CPA, indomethacin and diazepam. Cyproheptadine and vinblastine pretreatment however, prevented only the increased permeability of BBB, the plasma and brain 5-HT level continued to remain high. These results indicate a probable role of 5-HT as one of the factors leading to the increased permeability of BBB in young rats following heat stress.
D000818:Animals; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D003533:Cyproheptadine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006359:Heat Exhaustion / Q000503:physiopathology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010539:Permeability; D051381:Rats; D012701:Serotonin / Q000097:blood / Q000502:physiology*; D014747:Vinblastine / Q000494:pharmacology
D003533:Cyproheptadine; D012701:Serotonin; D014747:Vinblastine; D003975:Diazepam; D010134:Fenclonine; D007213:Indomethacin