Effects of bis (tri-n-butyltin) oxide on endocrine and lymphoid organs of male rats.
A total of 160 Sprague-Dawley rats averaging in body weight, were used for histopathological and biochemical studies of toxicity of bis (tri-n-butyltin) oxide (TBTO). Short-term effects and long-term effects were examined. LD50 of TBTO by gastric tubing was 197 mg/kg. The effects of a single dose of TBTO were transient, and rapid recovery followed. TBTO at a a single dose of 100 mg/kg, or a total dose of 390 to 780 mg/kg in 13 weeks, or 780 to 1,560 mg/kg in 26 weeks, caused adrenal hypertrophy, flattening of the thyroid epithelium and atrophy of the thymus and lymph nodes. A single or repeated administration induced swelling and vacuolation of aldehyde-fuchsin-positive cells in the adenohypophysis. The immunohistochemical stainability of the cytoplasm of ACTH-cells was markedly depressed 24 hours after TBTO treatment, and that of the cytoplasm of TSH-cells was enhanced. Analogous an inverse relationship was also manifested in the hormonal levels of serum: levels of cortisol were elevated, while those of T-4 and TSH were depressed.
D000311:Adrenal Glands / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000818:Animals; D004702:Endocrine Glands / Q000187:drug effects*; D006128:Growth / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000473:pathology; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects; D013972:Thyrotropin / Q000032:analysis; D014220:Trialkyltin Compounds / Q000633:toxicity*
D014220:Trialkyltin Compounds; C005961:bis(tri-n-butyltin)oxide; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin