title: [Genetic control of mixed lymphocyte culture].
abstract: Eighteen healthy families were HLA typed with highly specific cytotoxic antisera; 10 of them were also HLA-DR typed. All of them were tested in the mixed lymphocyte culture. Two different methods of mixed lymphocyte culture-with respect to the number of cells used-were compared. The influence of D and DR antigens on mixed lymphocyte culture is discussed. A rather rare finding was that two unrelated people were homozygous for DR, but not for D and, hence, different with respect to their D and DR antigens. Seven individuals, among them two pairs of identical siblings, were found to be homozygous for HLA-D and HLA-DR. The possibility of using them as typing cells for the alleles of the HLA-D locus was discussed.
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D006580:Genetic Carrier Screening; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006650:Histocompatibility Testing / Q000379:methods*; D006720:Homozygote; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed / Q000379:methods*; D008297:Male; D010375:Pedigree
chemical_list: D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens
vernacular_title: Untersuchungen zur genetischen Steuerung der gemischten Lymphozytenkultur.