title: [Skin manifestations observed during treatment with penicillamine and its derivatives].
abstract: Many forms of toxidermia are observed during D-penicillamine therapy. The exact type seems to depend on the pathology for which the drug was prescribed; pemphigus during rheumatoid arthritis, perforating serpiginous elastoma in Wilson's disease, cystinuria... The two physiopathogenic mechanisms discussed, an autoimmune reaction and a direct action of D-penicillamine on the skin, would seem to be complementary.
mesh_terms: D003875:Drug Eruptions / Q000209:etiology*; D004547:Elastic Tissue / Q000187:drug effects; D006801:Humans; D010392:Pemphigus / Q000139:chemically induced; D010396:Penicillamine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D010406:Penicillins / Q000009:adverse effects; D011746:Pyrithioxin / Q000009:adverse effects; D012871:Skin Diseases / Q000139:chemically induced*
chemical_list: D010406:Penicillins; D011746:Pyrithioxin; D010396:Penicillamine
vernacular_title: Manifestations cutanées observées au cours des traitements par la pénicillamine et ses dérivés.