title: The role of local design in membranes.
abstract: The IMP arrays are integral membrane multiprotein complexes that may be site-specific control centers regulating the local concentration of specific ions by functioning as pumps, gates, or channels. In the case of the fusion rosette, an increase in Ca2+ may trigger local membrane fusion; in other cases, Ca2+ or H+ may be important physiological regulators. Ca2+ dependent regulatory proteins, such as calmodulin, and other parameters prevent widespread dispersion of the ions and permit fine local regulation.
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002462:Cell Membrane / Q000648:ultrastructure; D002923:Cilia / Q000648:ultrastructure; D005614:Freeze Fracturing; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000648:ultrastructure; D008565:Membrane Proteins / Q000032:analysis; D008566:Membranes / Q000187:drug effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D013768:Tetrahymena / Q000648:ultrastructure
chemical_list: D007473:Ion Channels; D008565:Membrane Proteins; D002118:Calcium