title: Hyperphagia and obesity. Relationship to medial hypothalamic lesions.
abstract: Progressive left hemiparesis followed by face and trunk cutaneous vasodilation and hyperphagia developed in a 28-year-old man. He began eating five to six meals a day and gained 16 kg in 60 days. Computed tomography disclosed a neoplastic lesion involving the midline via the hypothalamus and reaching the contralateral lenticular nucleus. Findings from endocrine studies, including thyroid-stimulating hormone, growth hormone, prolactin, and cortisol serum levels, were normal. Hyperphagia and consequent obesity were associated with bilateral destruction of the ventromedial hypothalamic area; cutaneous vasodilation was related to involvement of the preoptic area.
mesh_terms: D001835:Body Weight; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology; D001068:Feeding and Eating Disorders / Q000209:etiology*; D005909:Glioblastoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D006963:Hyperphagia / Q000209:etiology*; D007031:Hypothalamus / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000209:etiology*; D014664:Vasodilation