[Hemodynamic effects of Praxinor on the peripheral circulation (author's transl)].
Short-term effects of an association of two aminoalkyltheophyllines (praxinor) on blood pressure, heart rate, superficial wrist veins compliance, and blood flow in the hand, were studied after oral administration to ten subjects under resting conditions. Apart from the expected effects of blood pressure elevation and reduction in heart rate, the compliance of veins non-submitted to orthostatic constraint was lowered and drop in blood flow, mainly to the cutaneous areas was observed. The authors discuss the effects of volume distribution and blood flow modifications of general hemodynamic function.
D000284:Administration, Oral; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003187:Compliance; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006225:Hand / Q000098:blood supply; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010627:Phenethylamines / Q000008:administration & dosage / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013806:Theophylline / Q000031:analogs & derivatives*; D014655:Vascular Resistance / Q000187:drug effects; D014680:Veins / Q000187:drug effects; D014970:Xanthines / Q000008:administration & dosage / Q000494:pharmacology*
D002317:Cardiovascular Agents; D004338:Drug Combinations; D010627:Phenethylamines; D014970:Xanthines; C000147:cafedrine, theodrenaline drug combination; D013806:Theophylline
Effects du Praxinor sur l'hémodynamique d'un circulation périphérique.