[Electrical activity and Na, K-ATPase levels in an epileptic focus caused by application of penicillin to rat cerebral cortex and the effect of diazepam on them].
Penicillin application to the rat brain motor cortex resulted in appearance of interictal discharges and seizures. After diazepam injection (2 mg/kg) a 100% increase in Na, K-ATPase activity of neuronal membranes in the epileptogenic focus was shown as compared to enzyme activity before diazepam injection. Interictal discharges and seizures changed in different ways after intramuscular injection of diazepam. The frequency and amplitude variation of interictal discharges increased but the seizures were suppressed. These effects increased with the dose of diazepam. It is suggested that the different influence of diazepam upon seizures and interictal discharges may reflect different mechanisms of these phenomena.
D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology / Q000503:physiopathology*; D003975:Diazepam; D004594:Electrophysiology; D008297:Male; D010406:Penicillins; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000201:enzymology / Q000503:physiopathology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D010406:Penicillins; D000254:Sodium-Potassium-Exchanging ATPase; D003975:Diazepam
Elektricheskaia aktivnost' i uro ven' Na, K-ATFazy v épilepticheskom ochage, obrazovannom deistviem penitsillina na koru golovnogo mozga krys, i vliianie na nikh diazepama.