title: A model for biological oscillations.
abstract: A model and computation for oscillatory phenomena observed in some biological processes that utilize ion gradients across a membrane is presented. The model contains two main features: (i) active H+ transport pathways in the membrane and (ii) key enzymes having a pH-dependent activity profile and either translocating H+ from outside or producing H+ as a product. With this model a very long period of oscillations, as observed in mitochondrial and circadian rhythms, could be quantitatively demonstrated.
mesh_terms: D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000502:physiology; D002940:Circadian Rhythm; D005246:Feedback; D006863:Hydrogen-Ion Concentration; D008564:Membrane Potentials; D008566:Membranes / Q000502:physiology; D008954:Models, Biological; D010507:Periodicity; D011522:Protons
chemical_list: D002352:Carrier Proteins; D011522:Protons