Efficacy of acyclovir against mouse cytomegalovirus in vivo.
Acyclovir reduced mortality and organ virus titers in mice inoculated intraperitoneally with 10 50% lethal doses of mouse cytomegalovirus. This susceptibility to acyclovir of a herpesvirus which lacks thymidine kinase is surprising. Alternative phosphorylating enzymes may account for this susceptibility.
D000212:Acyclovir; D000818:Animals; D002478:Cells, Cultured; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D005347:Fibroblasts; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051379:Mice; D008805:Mice, Inbred A
D006147:Guanine; D000212:Acyclovir