title: Neonatal susceptibility to MHV3 infection in mice. II. Role of natural effector marrow cells in transfer of resistance.
abstract: Protection of newborn mice against MHV3 infection requires the transfer of several cell populations originating from adult syngeneic donors: adherent spleen cells, T lymphocytes, and a third population present in the nonadherent spleen cell fraction, in peritoneal exudates, and in bone marrow cells (M cells). M cells were found to be sensitive to short-term incubation at 37 degrees C and to preincubation with anti-bone marrow antiserum, mitomycin C, puromycin, and aggregated Ig, the latter suggesting the presence of Fc receptors. They were resistant to silica particles but were sensitive to irradiation with x-rays as well as with 89Strontium. Nonadherent spleen cells, however, behaved differently from M cells toward x-irradiation since they were radio-resistant, suggesting that M cells are precursors that require further differentiation or division to participate in MHV3 resistance. Effector M cells responsible for MHV3 resistance display, therefore, some similarities with natural killing cells. They might belong to a group of effector cells operative in regulatory processes or anti-tumor surveillance but also may be defense mechanisms against infectious diseases.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001853:Bone Marrow / Q000276:immunology* / Q000528:radiation effects; D002448:Cell Adhesion; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000517:prevention & control*; D007113:Immunity, Innate; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008811:Mice, Inbred DBA; D006517:Murine hepatitis virus / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology; D013154:Spleen / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors