The emergence, localization, and maturation of neurotransmitter systems during development of the retina in Xenopus laevis: II. Glycine.
The high-affinity uptake and release of glycine was studied in retinas of Xenopus laevis. In the toad and tadpole retina, 3H-glycine was accumulated by a population of cells located predominantly in the inner nuclear layer. When retinas preloaded with 3H-glycine were subjected to high K+-concentrations, these retinas released large amounts of 3H-glycine by a Ca++-dependent mechanism. The appearance and maturation of these putative glycinergic properties was followed during retinal development. Our results indicate that the high-affinity uptake of glycine first appears around stage 33/34 whereas K+-stimulated glycine release cannot be detected until stage 42.
D000818:Animals; D001345:Autoradiography; D002118:Calcium / Q000502:physiology; D005998:Glycine / Q000378:metabolism*; D007814:Larva; D008854:Microscopy, Electron; D011188:Potassium / Q000494:pharmacology; D012160:Retina / Q000254:growth & development* / Q000378:metabolism / Q000648:ultrastructure; D009435:Synaptic Transmission; D014982:Xenopus laevis / Q000254:growth & development*
D011188:Potassium; D002118:Calcium; D005998:Glycine