Phospholipid acyl group composition in normal and tumoral nerve cells in culture.
We have studied the fatty acid composition of total phosphoglycerides from various types of nerve cells in culture. Primary cell cultures were compared with tumoral cell strains. Glial cells exhibited no characteristic pattern when compared to neurons. Tumoral cell phosphoglycerides contained much higher levels of octadecenoic acid and lower levels of C-20 to C-22 polyunsaturated fatty acids than normal cell phosphoglycerides. This observation seems to be a general feature in tumoral cell membranes. It could be of interest in respect to the membrane fluidity of cancer cells.
D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D005994:Glycerophosphates / Q000032:analysis*; D051379:Mice; D009374:Neoplasms, Experimental / Q000032:analysis; D009447:Neuroblastoma / Q000032:analysis*; D009457:Neuroglia / Q000032:analysis; D009474:Neurons / Q000032:analysis*; D051381:Rats; D013539:Simian virus 40
D005231:Fatty Acids, Unsaturated; D005994:Glycerophosphates