title: Megakaryoblastic leukemia presenting as acute myelofibrosis -- a study of four cases with the platelet-peroxidase reaction.
abstract: Acute myelofibrosis (AM) or malignant myelosclerosis is a myeloprofilerative syndrome in which bone marrow fibrosis is associated with a proliferation of immature myeloid cells. In four patients with typical AM, investigated by the platelet-peroxidase reaction at ultrastructural level, the blast cells were found to be megakaryoblasts. One patient, treated with the drug combination DAT, achieved a complete remission of 5 mo duration. This study supports the view that megakaryoblastic leukemia is the most frequent underlying cause of AM and proposes that it should be classified as a form of acute myeloid leukemia.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000648:ultrastructure; D008875:Middle Aged; D009195:Peroxidase; D010544:Peroxidases; D055728:Primary Myelofibrosis / Q000097:blood*; D013920:Thrombocythemia, Essential / Q000097:blood*
chemical_list: D010544:Peroxidases; D009195:Peroxidase