[Principle of parametric ion separation in a molecular model of the sodium pump].
Expressions were obtained for separation coefficients of sodium and potassium ions in macroscopic and molecular models of the sodium pump. Conjugation between the energy-donor process at ATP hydrolysis and ion transport is achieved at the expense of synchroneous changes of the affinity of ion-binding centers and divided cations. i. e. the cyclic changes of energetic profiles in the membrane for each type of ions. The division coefficient in the stationary state is equal to the product of relative changes in selectivity towards the cations of the enzyme ion-binding centers in phosporylated and unphosphorylated states.
D000255:Adenosine Triphosphate / Q000378:metabolism; D002411:Cation Exchange Resins; D002463:Cell Membrane Permeability; D008954:Models, Biological; D008956:Models, Chemical; D010766:Phosphorylation; D011188:Potassium / Q000378:metabolism; D011487:Protein Conformation; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002411:Cation Exchange Resins; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
Printsip parametricheskogo razdeleniia ionov v molekuliarnoĭ modeli natrievogo nasosa.