In vitro method for evaluation of spermicides by hemolytic potency.
Nonoxynol-9 immobilizes sperm and hemolyzes erythrocytes at analogous concentrations; therefore, erythrocytes may be utilized for predicting in vitro spermicidal potency. Since erythrocytes (human or rabbit) are usually more readily available in larger quantities than are spermatozoa, this method permits extensive in vitro testing of different formulations of vaginal spermicides.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects; D005069:Evaluation Studies as Topic; D006461:Hemolysis; D006801:Humans; D017137:Nonoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011817:Rabbits; D012661:Semen / Q000187:drug effects; D013089:Spermatocidal Agents / Q000494:pharmacology*
D013089:Spermatocidal Agents; D017137:Nonoxynol; D011092:Polyethylene Glycols