Fetal calf serum and epidermal growth factor prevent the inhibitory action of a chalone-like growth inhibitor for Ehrlich ascites mammary carcinoma cells in vitro.
A growth inhibitor for the Ehrlich ascites mammary carcinoma, purified from bovine mammary gland, is antagonized by very low concentrations of epidermal growth factor (2-16 X 10(-10) M) or fetal calf serum (0.001-0.1%). Thus, epidermal growth factor and the compounds in fetal calf serum have the same effect as earlier described for insulin and proinsulin [1-3].
D000818:Animals; D001769:Blood; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D003470:Culture Media; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D005333:Fetus; D006131:Growth Inhibitors / Q000494:pharmacology*; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000502:physiology; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains
D003470:Culture Media; D006131:Growth Inhibitors; D004815:Epidermal Growth Factor