Isolation of a new strain of cytomegalovirus from explanted normal skin.
Forty-three fibroblast cell line were initiated from normal skin biopsies. One cell line from a patient with Charcot--Marie--Tooth disease (CMT) spontaneously developed c.p.e. suggestive of cytomegalovirus (CMV). Characterization of the virus showed it to be a new strain of CMV and the results suggested that skin fibroblasts from CMT patients may carry latent CMV.
D002460:Cell Line; D002607:Charcot-Marie-Tooth Disease / Q000382:microbiology* / Q000473:pathology; D003587:Cytomegalovirus / Q000032:analysis / Q000254:growth & development / Q000302:isolation & purification*; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral / Q000032:analysis; D005347:Fibroblasts / Q000382:microbiology; D006801:Humans; D009133:Muscular Atrophy / Q000382:microbiology*; D012867:Skin / Q000382:microbiology*
D004279:DNA, Viral