[Staphylococcal induction of suppressors of macrophage phagocytic activity].
During experimental infection caused by S. aureus, strain Smith, the formation of suppressors of the phagocytic activity of macrophages was induced in the peritoneal cavity and the spleen of intact and infected mice. Thus, in the cultivation of macrophages of the infected mice together with nonadhering cells of the peritoneal exudate of the infected animals the phagocytic index was 0.75 +/- 0.09; in the presence of splenocytes of the infected mice the phagocytic index for macrophages of the intact and infected animals was 0.64 +/- 0.12 and 0.89 +/- 0.04, respectively. Splenocytes of the intact mice, when cultivated together with macrophages of the infected mice, enhanced phagocytic activity during the first hours of cultivation and suppressed it after prolonged cultivation (12 hours); the phagocytic index was 1.37 +/- 0.18 and 0.82 +/- 0.03, respectively.
D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D002448:Cell Adhesion; D002478:Cells, Cultured; D007108:Immune Tolerance; D008262:Macrophage Activation; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis; D013154:Spleen / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
Induktsiia stafilokokkom supressorov fagotsitarnoĭ aktivnosti makrofagov.