Pancreatic secretion and cyclic AMP in pancreatic tissue after intravenous infusion of secretin and vasoactive intestinal peptide in cats.
This study demonstrates that secretin and vasoactive intestinal peptide increased dose-dependently pancreatic bicarbonate secretion and cyclic AMP content in pancreatic tissue homogenates in cats. It is concluded that both hormones may act on the same receptor site in the pancreas and that their action is based on stimulation of the adenylate cyclase-cyclic AMP system.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D002415:Cats; D000242:Cyclic AMP / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D007263:Infusions, Parenteral; D010179:Pancreas / Q000378:metabolism*; D010185:Pancreatic Fistula; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology*; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000494:pharmacology*
D001639:Bicarbonates; D005768:Gastrointestinal Hormones; D012633:Secretin; D014660:Vasoactive Intestinal Peptide; D000242:Cyclic AMP