Small intestinal epithelial brush border enzymatic changes in suckling mice infected with reovirus type 3.
Suckling mice infected with reovirus type 3 were examined for changes in the epithelial brush border of the small intestine. After 3 days of infection with reovirus type 3, no significant changes were found in intestinal morphology or activity of any enzymes tested. After 6 days, villi were shortened and blunted with lymphangiectatic lesions and mild mononuclear infiltration in the lamina propria. In addition, there was a significant decrease in lactase (P < 0.001) and enterokinase activity (P < 0.05). However, there were no significant changes in the activities of alkaline phosphatase. In contrast, maltase (P < 0.001) and leucine aminopeptidase (P < 0.05) activities in the infected mice were significantly increased. These data suggest that brush border enzymes are affected differently by reovirus infection.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000833:Animals, Suckling; D007422:Intestines / Q000201:enzymology* / Q000473:pathology / Q000648:ultrastructure; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D012089:Mammalian orthoreovirus 3; D051379:Mice; D008871:Microvilli / Q000201:enzymology; D012088:Reoviridae Infections / Q000201:enzymology* / Q000473:pathology; D000520:alpha-Glucosidases / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
D000469:Alkaline Phosphatase; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D007931:Leucyl Aminopeptidase