[DNA synthesis and antibody formation in spleen cells of the mouse after in vivo immunization by Escherichia coli lipopolysaccharide modified by polymyxin B].
The addition of polymyxin B to Escherichia coli lipopolysaccharide alters some properties of this molecule, when injected to the Mouse. Spleen cells DNA synthesis was inhibited and delayed when the other functions tested: specific antibody synthesis ad immunoglobulin synthesis were unchanged. The possible implications of this dissociation are discussed.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D004247:DNA / Q000096:biosynthesis*; D004926:Escherichia coli / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D051379:Mice; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D000907:Antibodies, Bacterial; D008070:Lipopolysaccharides; D011113:Polymyxins; D004247:DNA; D011112:Polymyxin B
Synthèse d'ADN et synthèse d'anticorps dans les cellules spléniques de la souris, après immunisation, in vivo, par le lipopolysaccharide d'Escherichia coli, modifié par la polymyxine B.