[Effect of histones on mouse liver mitochondria cytochrome oxidase activity in vitro and in vivo].
Histones at concentration of 2-10 micrograms/ml activated the mitochondrial cytochrome oxidase and at concentration of 25 micrograms/ml and higher--inhibited the enzyme in vitro. Cytochrome oxidase was completely inactivated by histones at concentration of 100 mg/microliter and higher. After administration in vivo histones modified the reaction of liver mitochondria in response to the subsequent treatment with a non-ion detergent Triton X-100. Possible pathogenetic importance of the phenomena observed is discussed.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004789:Enzyme Activation; D005260:Female; D006657:Histones / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D008809:Mice, Inbred C3H; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats
D006657:Histones; D003576:Electron Transport Complex IV
Vliianie gistonov na aktivnost' tsitokhromoksidazy mitokhondriĭ pecheni mysheĭ in vitro i in vivo.