title: [Liver cell carcinoma following juvenile acute lymphoblastic leukemia. Case contribution].
abstract: The case history of a boy suffering from acute lymphoblastic leukemia (ALL) and carcinoma of the liver as secondary malignoma is reported. After completion of the combined ALL-therapy, a splenogenous thrombocytopenia emerged which was successfully treated by splenectomy. In the biopsy material liver cirrhosis and HBsAg-positive hepatitis could be detected; these proved to be progressive in the course of the following year. At the end of another year, a hepatocellular carcinoma was diagnosed, causing the patient's death, who was still in complete  hematological remission 5 7/12 years after the onset and 2 9/12 years after the end of the ALL-therapy. Only two cases of hepatocellular carcinoma following ALL in childhood have been described in the literature so far.
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications*; D002675:Child, Preschool; D006505:Hepatitis / Q000150:complications; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000188:drug therapy; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms; D008297:Male; D012075:Remission, Spontaneous
chemical_list: D006511:Hepatitis B Antigens
vernacular_title: Leberzellkarzinom nach akuter lymphoblastischer Leukose im Kindesalter. Kasuistischer Beitrag.