title: Inactivated vaccine for parrot herpesvirus infections (Pacheco's disease).
abstract: Four tests of an inactivated emulsified vaccine against a herpesvirus infection (Pacheco's disease) in bodgerigars demonstrated that an effective vaccine could be produced with concentrated virus. Virus was propagated in chicken kidney cells, and cells and fluid were harvested 3 to 5 days after inoculation and sonicated. The virus was concentrated 100 x by centrifugation to produce a multiple emulsion vaccine that was protective against IM challenge exposure with live virus. The serologic response after vaccination was negligible, and many survivors to virus challenge exposure did not show a positive titer.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001715:Bird Diseases / Q000517:prevention & control*; D006564:Herpesviridae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D010240:Parakeets; D011563:Psittaciformes; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines