title: Characteristics of lymphocyte and macrophage reactivity in otitis media with effusion.
abstract: On the basis of our observations and previously published data, it is proposed that in at least certain forms of chronic otitis media with effusion there is a relative predominance of macrophage--monocyte cells which are actively immunosuppressive for the proliferative response to mitogens and specific antigens, as well as for the synthesis of specific immunoglobulins. Such immunological hypo-responsiveness may be related to the pathogenesis of chronic otitis media with such effusions.
mesh_terms: D000234:Adenoids / Q000276:immunology; D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004432:Ear, Middle / Q000276:immunology; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008934:Mitogens / Q000494:pharmacology; D010033:Otitis Media / Q000276:immunology*; D010034:Otitis Media with Effusion / Q000276:immunology*
chemical_list: D008934:Mitogens