The fate of a large bolus of exogenous estrogen administered to postmenopausal women.
Seventeen postmenopausal women were given a bolus of conjugated estrogens (USP,  Premarin), 17 beta-estradiol and estriol orally, intravenously or by pellet implantation, and circulating levels of estrone, estradiol and/or estriol were measured by radioimmunoassay at various intervals during a 48--72-h period. Oral administration resulted in a marked rise in serum estrone; parenteral administration resulted in a marked increased in serum estradiol. There was no significant fall in serum gonadotropins during this period. Following estriol administration orally, there was a decided elevation in estriol levels but minimal change in estrone and estradiol.
D000284:Administration, Oral; D000328:Adult; D004958:Estradiol / Q000008:administration & dosage; D004964:Estriol / Q000008:administration & dosage; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged
D004966:Estrogens, Conjugated (USP); D004958:Estradiol; D004964:Estriol