The influences of glucagon, epinephrine and alpha- and beta-adrenergic agents on glycogenolysis in isolated rabbit hepatocytes and perfused livers.
1. Glucagon, epinephrine, norepinephrine, dibutyryl cyclic AMP, isoproterenol and phenylephrine each enhance glycogenolysis in isolated perfused rabbit livers and/or hepatocytes. 2. Such enhancement by epinephrine, norepinephrine, isoproterenol and phenylephrine is eliminated by propranolol but unaltered by phentolamine, suggesting that stimulation of glycogenolysis by each of these agents involves beta-adrenergic-mediated mechanism(s). 3. Data obtained with hepatocytes from 16--20-week-old rabbits and from 7--8-week-old rabbits are identical as far as enhancement of glycogenolysis by beta-adrenergic stimulation is concerned, implying that the nature of functional adrenergic receptors in rabbit liver does not change during the process of maturation.
D000526:Alprenolol / Q000031:analogs & derivatives*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004082:Dihydroalprenolol / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D005934:Glucagon / Q000494:pharmacology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology*; D011817:Rabbits
D008112:Liver Glycogen; D010656:Phenylephrine; D004082:Dihydroalprenolol; D003994:Bucladesine; D000526:Alprenolol; D005934:Glucagon; D000242:Cyclic AMP; D007545:Isoproterenol; D004837:Epinephrine; D010646:Phentolamine