title: [Monotherapy of hypertension with a beta-blocker in a single daily dose (author's transl)].
abstract: Timolol, a non selective beta-blocker was used one daily at a dosage of 10 to 20 mg, in 60 hypertensive patients with a diastolic blood pressure ranging from 100 to 120 mmHg. After 4 weeks of treatment, timolol had normalized diastolic blood pressure in 70% of patients ( less than 100 mmHg). compared to an initial treatment period with placebo (p less than 0.001). Tolerance of timolol was good, adverse clinical effects supervening in only 8% of patients (bradycardia, Raynaud's syndrome); no variation in laboratory values was observed.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000008:administration & dosage*; D013999:Timolol / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D011412:Propanolamines; D013999:Timolol
vernacular_title: Monothérapie de l'hypertension artérielle par un bêta-bloquant en prise unique quotidienne.