BALB/c myeloma retroviruses have mink cell focus-inducing activity.
We have determined the in vitro host range of the cloned MO-21 and FL-1 murine myeloma retroviruses grown in SC-1 cells that were originally isolated from cloned MOPC-21 and FLOPC-1 BALB/c plasmacytoma cell lines. These viruses are able to replicate in murine (BALB/3T3, NIH/3T3) as well as numerous heterologous cell lines. These myeloma retroviruses also exhibit mink cell focus-inducing activity. MO-21 and FL-1 shared interference patterns with each other, but their replication was not interfered with by ecotropic, xenotropic, or amphotropic viruses. The lack of cross-interference with ecotropic or xenotropic viruses distinguishes these isolates from other mink cell focus-inducing viruses.
D000818:Animals; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D017988:Gammaretrovirus / Q000254:growth & development*; D051379:Mice; D008807:Mice, Inbred BALB C; D008907:Mink; D009101:Multiple Myeloma; D013045:Species Specificity; D014762:Viral Interference