Neutralization of the effect of delta 9-tetrahydrocannabinol on barbiturate sleeping time by specific active immunization.
Adult mice were actively immunized with delta 9-tetrahydrocannabinol-bovine serum albumin (delta 9-THC-BSA) conjugate. Control animals were immunized with BSA alone. While the administration of pentobarbital and delta 9-THC to control animals resulted in the well known prolongation of the barbiturate sleeping time, in mice immunized with delta 9-THC-BSA conjugate this effect was almost completely neutralized.
D000818:Animals; D013759:Dronabinol / Q000276:immunology / Q000494:pharmacology*; D004357:Drug Synergism; D007110:Immunity, Active; D007114:Immunization; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000276:immunology; D012890:Sleep / Q000187:drug effects*
D012710:Serum Albumin, Bovine; D013759:Dronabinol; D010424:Pentobarbital