Vitamin D metabolism in hypophosphatemic vitamin D-resistant rickets.
Plasma levels of 1,25-(OH)2-D were low in children with hypophosphatemic vitamin D-resistant rickets (HVDRR), but increased after very large doses of 1 alpha-OH-D3. These results suggest that the metabolism of 1,25-(OH)2-D is accelerated in HVDRR. In addition, the lower level of plasma 1,25-(OH)2-D in untreated HVDRR was correlated with the lower level of serum phosphate and renal threshold phosphate concentration (TmP/GFR). The administration of 1 alpha-OH-D3 to the patients with HVDRR could enhance the renal threshold phosphate concentration.
D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood / Q000652:urine; D002675:Child, Preschool; D003404:Creatinine / Q000378:metabolism; D000242:Cyclic AMP / Q000652:urine; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000378:metabolism*; D007223:Infant; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000652:urine; D014807:Vitamin D / Q000378:metabolism*
D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D003404:Creatinine; D000242:Cyclic AMP; D000469:Alkaline Phosphatase; D002118:Calcium