Regulation of proliferation of normal and neoplastic rat liver cells by calcium and cyclic AMP.
Calcium and cyclic AMP control the proliferation of nontumorigenic liver cells. These agents seem to be cogenerators of a signal to start synthesizing deoxyribonucleotides, the earliest of the DNA synthetic processes. By contrast, calcium has little or no effect on the proliferation of tumorigenic cells in vitro. Some possible reasons for this loss of control are presented, and the usefulness of this property as a tool for the detection of carcinogens is discussed.
D000818:Animals; D017317:Annexin A6; D002118:Calcium / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D000242:Cyclic AMP / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D007399:Interphase; D008099:Liver / Q000166:cytology*; D008113:Liver Neoplasms / Q000473:pathology*; D051379:Mice; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats
D017317:Annexin A6; D002135:Calcium-Binding Proteins; D004247:DNA; D000242:Cyclic AMP; D011494:Protein Kinases; D002118:Calcium