title: Nucleotide sequence changes in polyoma ts-a mutants: correlation with protein structure.
abstract: The mutations in three polyoma ts-a mutants have been determined. Two mutants, ts-25 and ts-52, have different single-base changes at the same position (2883) in the early region corresponding to a conserved glycine residue very near the C-terminus of the polyoma large T antigen. Mutant ts-48 has a single-base change at position 2341, as well as a second change at position 1228, in the region of large T antigen shared with medium T antigen.
mesh_terms: D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm / Q000235:genetics*; D000956:Antigens, Viral / Q000235:genetics*; D001483:Base Sequence; D005814:Genes, Viral; D009154:Mutation; D011120:Polyomavirus / Q000235:genetics* / Q000276:immunology; D013696:Temperature
chemical_list: D000951:Antigens, Neoplasm; D000956:Antigens, Viral