title: Subclinical infectious bursal disease in commercial broiler flocks in Saskatchewan.
abstract: Five commercial broiler flocks, not vaccinated for infectious bursal disease virus, derived from infectious bursal disease virus-vaccinated breeder flocks were surveyed for evidence of bursal damage and infectious bursal disease virus infection. They were compared with two groups of birds raised in isolation. Serum samples from one day old chicks contained maternal anti-infectious bursal disease virus antibodies which declined to undetectable levels by four weeks of age. Serum antibody levels remained undetectable in both control groups and one commercial flock, whereas four of the five commercial flocks had actively produced anti-infectious bursal disease virus antibodies by slaughter age. The weight of bursae from infectious bursal disease virus-positive flocks declined as compared to controls after four weeks of age. The decline in weight correlated with the appearance of histopathological lesions. Infectious bursal disease virus antigen was demonstrated in selected infected bursae and infectious bursal disease bursae and infectious bursal disease virus was isolated from some of these damaged bursae. Clinical infectious bursal disease was not observed in any of the commercial flocks. The importance of subclinical bursal damage and immunosuppression is discussed.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D007243:Infectious bursal disease virus / Q000276:immunology; D011201:Poultry Diseases / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D012088:Reoviridae Infections / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D012525:Saskatchewan
chemical_list: D000914:Antibodies, Viral