Failure of neostigmine to prevent tubocurarine neuromuscular block in the isolated arm.
Neostigmine failed to modify the development of neuromuscular block in the presence of a high local concentration of tubocurarine. Only when the concentration of tubocurarine was reduced, and a suitable concentration gradient established between the receptor area and the plasma, did neostigmine increase the rate of recovery from the action of non-depolarizing neuromuscular blocking agents.
D001132:Arm; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000037:antagonists & inhibitors*
D009388:Neostigmine; D014403:Tubocurarine