Biphasic effect of thyrotropin-releasing hormone on membrane K+ permeability in rat clonal pituitary cells.
The effect of thyrotropin-releasing hormone (TRH) on the membrane electrical properties of the rat clonal pituitary cell (GH3) was studied in Cl- -free solution. TRH induced biphasic changes in the membrane K+ permeability, namely a transient increase followed by a prolonged decrease. The late decrease in K+ permeability is responsible for the enhanced generation of action potentials.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002999:Clone Cells; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D007473:Ion Channels; D013973:Thyrotropin-Releasing Hormone; D011188:Potassium