Effect of prostacyclin on platelet-activating factor induced rabbit and platelet aggregation.
In this paper, the effect of prostacyclin (PGI2) on the aggregation induced by Platelet-activating factor (PAF), a phospholipid mediator of anaphylaxis, was studied. Synthetic PGI2 and PGI2-like activity generated from rabbit aorta were demonstrated to be effective inhibitors of PAF-induced rabbit platelet aggregation and release of 3H-serotonin (3H-5HT).
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000502:physiology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D003994:Bucladesine / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D007700:Kinetics; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology
D008244:Lysophosphatidylcholines; D010972:Platelet Activating Factor; D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; D012701:Serotonin; D000244:Adenosine Diphosphate; D003994:Bucladesine; D013806:Theophylline; D011464:Epoprostenol; D007545:Isoproterenol