Electrophysiological modifications induced by the fluorescent probe, pyrene, on Myxicola giant axons.
Current- and voltage-clamp experiments on Myxicola giant axons labelled with pyrene showed decreased Na+ and K+ conductances. The low-frequency membrane capacity and the gating charge transfer were slightly reduced. It may be inferred that pyrene is incorporated in some hydrophobic membrane domains close to the ionic channels.
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000502:physiology; D004553:Electric Conductivity; D004594:Electrophysiology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D011077:Polychaeta; D011188:Potassium / Q000378:metabolism; D011721:Pyrenes / Q000378:metabolism / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D011721:Pyrenes; D012964:Sodium; D011188:Potassium