[Transfer of information from T and B lymphocytes during immune response: role of extracellular DNA].
Human lymphocytes obtained from donors exhibiting different allotypes were separated into B and T subpopulations and cultured in presence or in absence of UV-inactivated Herpes simplex virus. Isolated B or T cells did not produce antiherpetic activity. The B lymphocytes, cultured in presence of the supernatant collected from virus exposed T cells or in the presence of DNA extracted from this supernatant, synthesized an antiherpetic antibody carrying allotypic markers of the T cell donor.
D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D004247:DNA / Q000276:immunology*; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D007126:Immunoglobulin Allotypes; D004247:DNA
Transfert d'information de lymphocytes T à B au cours d'une réponse immune: rôle de l'ADN extracellulaire.