Controlled release of biologically active compounds from bioerodible polymers.
This article reviews the controlled release of biologically active agents by the erosion or chemical degradation of a polymer matrix into which the agent is incorporated. Chemically bound active agents and work on steroid release from cholesterol implants are not covered. The mechanisms of polymer erosion discussed are: cross-linked scission; hydrolysis, ionization or protonation of pendant groups; backbone cleavage. Drug release studies are dealt with under each of these headings.
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004058:Diffusion; D006868:Hydrolysis; D007477:Ions; D011522:Protons; D014867:Water
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D007477:Ions; D011522:Protons; D014867:Water