Stimulation of calcium efflux from rat liver mitochondria by adenosine 3'5 cyclic monophosphate.
The uptake or release of Ca2+ from rat liver mitochondria was studied by means of a sensitive Ca-electrode. It was found that using palmitoyl coenzyme A together with carnitine and ATP as substrates that Ca2+ was released gradually from mitochondria by adenosine 3'5' cyclic monophosphate. The effect was obtained with either mitochondria preloaded with Ca2+ or with their physiological content of Ca2+. No such release was obtained with the usual substrates used to provide energy for Ca2+ uptake by mitochondria.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002331:Carnitine / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology*; D005215:Fasting; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010171:Palmitoyl Coenzyme A / Q000378:metabolism; D051381:Rats
D010171:Palmitoyl Coenzyme A; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D002331:Carnitine; D002118:Calcium