title: "In vivo" and "in vitro" effects of a bacterial extract on Herpes Simplex Virus.
abstract: The present studies were designed to evaluate the effects of substance or substances extracted from Escherichia coli on Herpes Simplex Virus. The "in vivo" assays show that bacterial extract introduced i.p. in mice simultaneously with HSV2 brought about 100% of survival, but the inoculation of crude extract after virus challenge brought about complete mortality of mice. "In vitro" assays show that the crude extract reduced significantly the numbers of PFU; better results were obtained when the crude extract was inoculated before the virus inoculation.
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli / Q000032:analysis*; D051379:Mice; D018139:Simplexvirus / Q000187:drug effects* / Q000472:pathogenicity; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents