Influence of 2,4,6-triamino-pyrimidyl-5-azobenzene on the activities of acid phosphatase, alkaline phosphatase and lactate dehydrogenase in cell cultures infected with herpes simplex virus type 1.
Treatment of VERO cells with 2,4,6-triamino-pyridimyl-5-azobenzene (10 gamma/ml) one hour after inoculation of herpes simplex virus type 1 limits the influence of the virus infection, consisting in the enchancement of the activities of alkaline phosphatase, acid phosphatase and LDH (especially of the latter two enzymes) and in changes in the isoenzyme patterns of acid and alkaline phosphatases and of peroxidase. In general the influence of the drug is expressed both by the fact that enzyme levels in homogenates of infected cells become closer to the values recorded in controls, and by modifications in the isoenzyme patterns altered by virus multiplication, making them more similar to those of uninfected, untreated cells.
D000135:Acid Phosphatase / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002478:Cells, Cultured; D000882:Haplorhini; D006561:Herpes Simplex / Q000201:enzymology*; D007527:Isoenzymes / Q000032:analysis; D007668:Kidney; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D010544:Peroxidases / Q000032:analysis; D011743:Pyrimidines / Q000494:pharmacology*; D018139:Simplexvirus; D014776:Virus Cultivation
D001391:Azo Compounds; D007527:Isoenzymes; D011743:Pyrimidines; C026106:IOB-207; D007770:L-Lactate Dehydrogenase; D010544:Peroxidases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase