title: Effect of Bordetella pertussis vaccination in mice and the isolated tracheal response to isoprenaline.
abstract: The administration of Bordetella pertussis vaccine to mice has been associated with the development of an impaired beta-adrenoceptor responsiveness and in many respects has resembled human asthma. Trachea (n = 12) were isolated from Swiss-Webster mice 5 days following the intraperitoneal administration of 2 x 10(9) B. pertussis organisms. The tracheal smooth muscle response to carbachol was measured and compared with that found in trachea from unvaccinated mice (n = 15). The contractile response was similar in both groups. The tracheal smooth muscle relaxant effects of isoproterenol were measured in these two groups. The EC50 value for isoprenaline (6.5 x 10(-7) M) in trachea from B. pertussis treated mice was significantly (P < 0.05) greater than that noted in the control animals (2.3 x 10(-7) M). These studies demonstrated that in tracheal smooth muscle isolated from B. pertussis vaccinated mice, the relaxant effects of isoprenaline are impaired.
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology*; D002217:Carbachol / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010567:Pertussis Vaccine / Q000009:adverse effects*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects* / Q000276:immunology
chemical_list: D010567:Pertussis Vaccine; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D006632:Histamine; D002217:Carbachol; D007545:Isoproterenol