title: Glucose suppresses basal firing and haloperidol-induced increases in the firing rate of central dopaminergic neurons.
abstract: In the rat, doses of glucose sufficient to raise glucose concentrations in the blood to levels equivalent to those produced by a meal or stress suppress the firing of dopamine-containing neurons located within the substantia nigra. Glucose also prevents or reverses the increase in discharge rates of dopaminergic cells normally elicited by the antipsychotic agent haloperidol.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D005632:Fructose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology*; D006220:Haloperidol / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D005632:Fructose; D005947:Glucose; D006220:Haloperidol; D004298:Dopamine