title: ACTH and resistance of small blood vessels to trauma: use of mucosal petechiometry.
abstract: The effect of an intramuscular injection of ACTH on the resistance to trauma of oral mucous membrane blood vessels was assessed by petechiometry. In a double-blind cross-over study involving 20 healthy volunteers, 18 showed a reduction in petechial count after the active injection but only nine did so after the injection of placebo. These findings may justify the use of ACTH in the management of patients with a history of haemorrhage after dental extraction.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D002196:Capillaries / Q000293:injuries; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000098:blood supply* / Q000187:drug effects; D006472:Oral Hemorrhage / Q000503:physiopathology; D010919:Placebos; D011897:Random Allocation
chemical_list: D010919:Placebos; D000324:Adrenocorticotropic Hormone