title: [Change in the cyclic nucleotide system components in neurogenic myopathies].
abstract: Values of Kdiss of the "protein kinase-cAMP" complex were decreased 2-6-fold in muscular tissue of patients with neurogenic myopathies. An increase in affinity of the protein kinase to cAMP correlated with the severity of the disease. Alteration in the cAMP-sGMP ratio, due to decrease in cGMP content, was found in patients with side amyotrophic sclerosis.
mesh_terms: D001706:Biopsy; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D009132:Muscles / Q000378:metabolism; D009468:Neuromuscular Diseases / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000378:metabolism*
chemical_list: D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D006152:Cyclic GMP
vernacular_title: Izmenenie nekotorykh komponentov sistemy tsiklicheskikh nukleotidov u bol'nykh nevrogennymi miopatiiami.