Experimentally induced synovial sarcoma.
Synovial sarcoma has been induced in the knee joints of rats by intra-articular injection of 9-10-dimethyl-1-2-benzanthracene. Tumours developed from three to six months after the last injection. The neoplasms obtained were classified as synovial sarcoma (50%), fibrosarcoma (25%), giant cell sarcoma (15%), malignant fibrous histiocytoma (10%). The synovial membrane in the treated knee joints presented a chronic synovitis associated with fibrosis and proliferation of the lining cells. The primitive tumour spread locally infiltrating muscle and the adjacent bones. Metastases occurred most frequently to the lungs (70%) and liver (20%); lymph nodes were involved in 10%.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005354:Fibrosarcoma / Q000139:chemically induced; D018219:Histiocytoma, Benign Fibrous / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013584:Sarcoma, Synovial / Q000139:chemically induced*; D013583:Synovial Membrane
D015127:9,10-Dimethyl-1,2-benzanthracene