Chromosome fragility and susceptibility of Bloom's syndrome fibroblasts to SV40 transformation.
A comparison of the frequencies of chromosomal aberrations and the rates of SV40 transformation was made using fibroblasts obtained from 2 patients with Bloom's syndrome (BS) and from a normal individual. BS cells were found to be more susceptible to chromosome damage, in confirmation of earlier reports, but surprisingly, BS cells were distinctly less prone to transformation.
D002472:Cell Transformation, Viral; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic; D004392:Dwarfism / Q000235:genetics; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D013539:Simian virus 40 / Q000472:pathogenicity*; D012854:Sister Chromatid Exchange; D013577:Syndrome