title: Familial chronic mucocutaneous candidiasis successfully treated with oral ketoconazole.
abstract: A father and son, both suffering from chronic mucocutaneous candidiasis, were successfully treated with oral ketoconazole, a water-soluble imidazole compound. No toxic side-effects occurred during treatment. Treatment was given for about 8 months with diminishing does of ketoconazole. The disease cleared completely about half-way through the course of treatment and did not relapse within 1 month of discontinuing the drug. The only immunological abnormality was a depression in vitro of neutrophil chemotaxis. This became normal during therapy and was regarded as being a result of the disease and not as its cause.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002177:Candidiasis / Q000188:drug therapy*; D002178:Candidiasis, Chronic Mucocutaneous / Q000188:drug therapy* / Q000235:genetics; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000627:therapeutic use; D007223:Infant; D007654:Ketoconazole; D008297:Male; D010879:Piperazines / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D007093:Imidazoles; D010879:Piperazines; D007654:Ketoconazole