Mecillinam susceptibility of Escherichia coli K-12 mutants deficient in the adenosine 3',5'-monophosphate system.
The mecillinam resistance of Escherichia coli K-12 mutants deficient in the enzyme responsible for the synthesis of adenosine 3',5'-monophosphate, adenylate cyclase, has been investigated. The results suggest that resistance to this antibiotic may be a consequence of the slow growth rate of these mutants rather than an intrinsic property of their genetic lesion.
D000560:Amdinocillin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D009154:Mutation; D010397:Penicillanic Acid / Q000494:pharmacology*; D010403:Penicillin Resistance; D013997:Time Factors
D010397:Penicillanic Acid; D000242:Cyclic AMP; D000560:Amdinocillin