title: The effect of amino-substitution on the beta-adrenoceptor activity of 4-bromophenylethanolamines.
abstract: A series of 4-bromophenylethanolamines with a variety of amino substituents has been prepared. A detailed pharmacological evaluation has been made of their beta-adrenergic activity to study how the amino substituent may effect the mixed agonist and antagonist action of a phenylethanolamine series.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014132:Trachea / Q000187:drug effects
chemical_list: D010627:Phenethylamines; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta