Histamine-activated adenylate cyclase in brain homogenates of several species.
Histamine has been shown to activate cyclic AMP synthesis in brain slices and homogenates of certain species, although less is known about species differences in brain homogenates. Dutch Belted and New Zealand White rabbit brain homogenates contained a histamine-responsive adenylate cyclase similar to that of the guinea pig. In contrast, adenylate cyclase of gerbil and hamster brain exhibited little or no stimulation by histamine. Male rat hypothalamic homogenates contained adenylate cyclase, but also exhibited minimal stimulation by histamine, in disagreement with some recent reports. Detailed studies of the conditions of assay failed to resolve this discrepancy.
D000262:Adenylyl Cyclases / Q000096:biosynthesis*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D006224:Cricetinae; D000242:Cyclic AMP / Q000096:biosynthesis; D004789:Enzyme Activation / Q000187:drug effects; D005849:Gerbillinae; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D006632:Histamine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases