Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets.
D000577:Amides / Q000494:pharmacology; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009243:NAD / Q000378:metabolism*; D009244:NAD+ Nucleosidase / Q000037:antagonists & inhibitors*; D009536:Niacinamide / Q000494:pharmacology; D010848:Picolinic Acids / Q000494:pharmacology*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011384:Proinsulin / Q000096:biosynthesis*; D051381:Rats; D013311:Streptozocin / Q000037:antagonists & inhibitors*
D000577:Amides; D010848:Picolinic Acids; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D009243:NAD; D009536:Niacinamide; D013311:Streptozocin; D011384:Proinsulin; D011065:Poly(ADP-ribose) Polymerases; D009244:NAD+ Nucleosidase; C003142:picolinamide