The uterotrophic effect of delta 9 THC in ovariectomized rats and mice.
We have reanalyzed the statistics on uterine weights used by Virgo in his article, The Estrogenicity of Delta-9-Tetrahydrocannabinol (THC): THC Neither Blocks nor Induces Ovum Implantation, nor does it Effect Uterine Growth, which appeared in Res. Comm. Chem. Path. and Pharmacol. 25:65-77 (1979). The reanalysis shows that administration of 3 and 6 mg/kg delta 9 THC to ovariectomized mice results in highly significant (P < .002; P < .0001 respectively) increases in uterine weights. These data are in accord with the uterotrophic effect of delta 9 THC observed in ovariectomized rats.
D000818:Animals; D002369:Castration; D013759:Dronabinol / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014599:Uterus / Q000187:drug effects*
D013759:Dronabinol