Inhibition of chemically induced carcinogenesis of canine cells in vitro by infection with mouse xenotropic type C virus.
C57L mouse xenotropic type C virus infection inhibited N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vitro transformation of embryo cells from inbred beagles. Treatment with MNNG induced in vitro neoplastic transformation in uninfected canine cells but not in C57L virus-infected canine cells; the C57L virus-infected canine cells not treated with MNNG also remained untransformed. In this dog cell system, preinfection with a C57L mouse xenotropic type C virus inhibited in vitro neoplastic transformation induced by MNNG.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004285:Dogs; D004622:Embryo, Mammalian; D008769:Methylnitronitrosoguanidine; D051379:Mice; D008810:Mice, Inbred C57BL / Q000382:microbiology; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000517:prevention & control; D012190:Retroviridae; D013045:Species Specificity; D014183:Transplantation, Heterologous
D008769:Methylnitronitrosoguanidine