title: Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung.
abstract: Spike electrogenesis, local depolarizing and hyperpolarizing responses, spontaneous rhythmic firing, and alternating resting potentials were measured in cells from a continuously cultured small cell carcinoma of the lung. Spike generation was blocked by MnCl2. In view of this evidence for calcium-spike electrogenesis and previous evidence of secretory activity in these cells, this cell line (DMS 53) can provide a model for the study of excitation-secretion behavior in human neoplastic cells.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D018288:Carcinoma, Small Cell / Q000503:physiopathology*; D002478:Cells, Cultured; D004553:Electric Conductivity; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology*; D008345:Manganese / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects
chemical_list: D008345:Manganese; D002118:Calcium