title: Gonadotropin release from pituitary cultures following activation of endogenous ion channels.
abstract: In primary rat pituitary cell cultures, activation of Na+ channels resulted in Na+ and Ca2+ dependent gonadotropin release. This occurred with the same efficacy and over the same time course as that stimulated by gonadotropin releasing hormone (GnRH). In contrast, GnRH required extracellular Ca2+, but not Na+ for its action. These results indicate that the gonadotrope has ion channels which resemble those found in neural tissues.
mesh_terms: D000157:Aconitine / Q000494:pharmacology; D000818:Animals; D001496:Batrachotoxins / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D004533:Egtazic Acid / Q000494:pharmacology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology; D014701:Veratridine / Q000494:pharmacology
chemical_list: D001496:Batrachotoxins; D007473:Ion Channels; D007987:Gonadotropin-Releasing Hormone; D013779:Tetrodotoxin; D004533:Egtazic Acid; D014701:Veratridine; D007986:Luteinizing Hormone; D012964:Sodium; D002118:Calcium; D000157:Aconitine