The interaction of cadmium and certain other metal ions with proteins and nucleic acids.
The toxic effects of cadmium and other selected divalent cations are presumed to be related to specific chemical and physical characteristics of the ion. The chemistry of cadmium and metal ions in general is reviewed from the viewpoint of such relevant properties as ion polarizability, electronic structure, and the hard-soft characteristics. The softness of metal ions is seen as a useful single parameter to correlate with the affinity for nucleic acids and proteins and with toxic effects. The effects of cadmium on nucleic acids and proteins are examined for a number of specific cases to illustrate the variety of interactions that are well recognized and to demonstrate the utility of soft metal ions as reagents and probes for examining the relationship of structure and function in these macromolecules.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000378:metabolism* / Q000494:pharmacology; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008668:Metallothionein / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D009696:Nucleic Acids / Q000378:metabolism*; D009705:Nucleosides / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013816:Thermodynamics
D000596:Amino Acids; D004791:Enzyme Inhibitors; D008670:Metals; D009696:Nucleic Acids; D009705:Nucleosides; D009711:Nucleotides; D011506:Proteins; D011687:Purines; D011743:Pyrimidines; D013438:Sulfhydryl Compounds; D002104:Cadmium; D004247:DNA; D012343:RNA, Transfer; D008668:Metallothionein; D000254:Sodium-Potassium-Exchanging ATPase