N-Oxide reduction by hemoglobin, cytochrome C and ferrous ions.
Indicine N-oxide is reduced to indicine by Fe(II) ions, by enzymatically reduced cytochrome c, and by ascorbic acid in conjunction with hemin or cytochrome c. Indicine N-oxide is not reduced by native hemoglobin, but is reduced by denatured hemoglobin. Oxygen competes with indicine N-oxide for reduction by denatured hemoglobin.
D000972:Antineoplastic Agents, Phytogenic / Q000097:blood*; D003497:Cyclic N-Oxides / Q000097:blood*; D003574:Cytochrome c Group / Q000097:blood*; D005296:Ferrous Compounds / Q000097:blood*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000097:blood*; D010084:Oxidation-Reduction; D011763:Pyrrolizidine Alkaloids / Q000097:blood*
D000972:Antineoplastic Agents, Phytogenic; D003497:Cyclic N-Oxides; D003574:Cytochrome c Group; D005296:Ferrous Compounds; D006454:Hemoglobins; D011763:Pyrrolizidine Alkaloids; C013095:indicine-N-oxide; D007501:Iron