Laboratory studies of disinfectants against Legionella pneumophila.
Legionella pneumophila suspended in tap water was exposed to biocides recommended for inhibiting biological growth in cooling towers and evaporative condensers of air-conditioning systems. Chlorine, 2,2-dibromo-3-nitrilopropionamide, and a compound containing didecyldimethylammonium chloride and isopropanol were effective in destroying concentratiois of 10(5) to 10(6) viable cells per ml. Formulations consisting of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, disodium ethylene bis(thiocarbamate) and sodium dimethyl dithiocarbamate, and a phenolic with pentachlorophenate and sodium salts of other chlorophenols were less effective.
D000433:1-Propanol / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D017610:Calcium Compounds; D002713:Chlorine / Q000494:pharmacology; D002733:Chlorophenols / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D006997:Hypochlorous Acid / Q000494:pharmacology; D007875:Legionella / Q000187:drug effects* / Q000254:growth & development; D009570:Nitriles / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology
D017610:Calcium Compounds; D002733:Chlorophenols; D004202:Disinfectants; D009570:Nitriles; D000644:Quaternary Ammonium Compounds; C004488:calcium hypochlorite; D002713:Chlorine; D006997:Hypochlorous Acid; C007320:2,2-dibromo-3-nitrilopropionamide; D000433:1-Propanol; D002118:Calcium; C027118:didecyldimethylammonium