title: Hepatocellular adenoma. Its transformation to carcinoma in a user of oral contraceptives.
abstract: Hepatocellular carcinoma arose in a hepatic adenoma associated with the use of oral contraceptives. Although surgical resection was successful, the patient died of sepsis a month postoperatively. No metastases were found at the time of autopsy. Ultrastructural studies of the tumor showed phospholipidosis suggestive of drug-induced toxicity.
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000209:etiology* / Q000473:pathology / Q000648:ultrastructure; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000648:ultrastructure; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D010743:Phospholipids
chemical_list: D003276:Contraceptives, Oral; D010743:Phospholipids