Clonidine-induced hyperphagia in monkeys: evidence for alpha 2-noradrenergic receptor mediation.
The mechanism of clonidine-induced hyperphagia and weight gain in monkeys was studied in 11 Stumptail macaques. Clonidine induced a significant increase in food intake over baseline levels and a significant weight gain after the 3-day treatment period. Both changes induced by clonidine were antagonized by the alpha 2-noradrenergic antagonist yohimbine, but not by prazosin, an alpha 1-noradrenergic antagonist. These results suggest that clonidine-induced hyperphagia and weight gain in monkeys are mediated through alpha 2-noradrenergic receptors.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004347:Drug Interactions; D001068:Feeding and Eating Disorders / Q000139:chemically induced*; D006801:Humans; D006963:Hyperphagia / Q000139:chemically induced*; D008251:Macaca; D009638:Norepinephrine / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D013566:Sympathomimetics / Q000494:pharmacology
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D013566:Sympathomimetics; D003000:Clonidine; D009638:Norepinephrine