A theoretical models of oncolysis by Clostridium oncolyticum M 55 ATCC 13,732.
Based on experimental data obtained by own experiments and investigations of other authors the first time it is tried to develop a new theoretical model of oncolysis by Clostridium oncolyticum M 55. The correlations between tumour, clostridial cells, the tumour kinin system and the immune system of the host are represented in their influence on oncolysis. The consequences for a therapeutic application of the tumour clostridia phenomenon are discussed.
D000818:Animals; D001920:Bradykinin / Q000378:metabolism; D003013:Clostridium / Q000201:enzymology / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D007705:Kinins / Q000378:metabolism; D051379:Mice; D003012:Microbial Collagenase / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000276:immunology*; D010101:Oxygen Consumption; D010447:Peptide Hydrolases / Q000378:metabolism; D051381:Rats; D013171:Spores, Bacterial / Q000276:immunology
D007705:Kinins; D010447:Peptide Hydrolases; D003012:Microbial Collagenase; D001920:Bradykinin