Interaction of N-(phosphonomethyl)glycine with some respiratory chain enzymes of isolated corn-shoot mitochondria.
Spectrophotometric measurements of the activities of some dehydrogenases and electron transfer complexes of isolated corn-shoot mitochondria revealed that N-(phosphonomethyl)glycine (PMG), a broad-spectrum, non-selective, and post-emergence herbicide, at a concentration of 6.25 x 10(-4)M enhanced by about 10% the activities of NAD+-linked malate and NAD+-linked isocitrate dehydrogenases. At concentrations of 5 x 10(-3)M and 10 x 10(-3)M PMG, the activities of succinate and the NAD+-linked dehydrogenases were reduced by at least 10% and 25%, respectively. Although no effect was observed on the activities of the electron transfer complexes at lower concentrations of PMG, these enzymes were inhibited by at least 10% and 20%, respectively, at 5.0 x 10(-3)M and 10 x 10(-3)M PMG.
D003576:Electron Transport Complex IV / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006540:Herbicides / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000378:metabolism; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D003313:Zea mays / Q000187:drug effects / Q000201:enzymology*; D000097797:Glyphosate
D003576:Electron Transport Complex IV; D005998:Glycine; D006540:Herbicides; D009245:NADH Dehydrogenase; D009252:NADPH Dehydrogenase; D009943:Organophosphorus Compounds; D013385:Succinate Dehydrogenase; D000097797:Glyphosate