[Effect of the polycationic antibiotic polymyxin B on the respiratory activity of rat liver mitochondria].
the mechanism of the effect of the peptide antibiotic polymixin B on respiration of rat liver mitochondria was studied. It was shown that polymixin B at concentrations of (1,6--2,0) . 10(-3) M inhibits mitochondrial respiration in state 3 and 3u irrespective of the oxidation substrate used and activates oxygen consumption in state 4 at lower concentrations. It is assumed that the antibiotic affects mitochondrial respiration by changing the ionic permeability of the membranes.
D000818:Animals; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects; D007700:Kinetics; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010539:Permeability; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D051381:Rats
D011113:Polymyxins; D011112:Polymyxin B
Deĭstvie polikationnogo antibiotika polimiksina v na dykhatel'nuiu aktinvost' mitokhndriĭ pecheni krys.