Association of Kaposi's sarcoma with second primary malignancies: possible etiopathogenic implications.
The association of Kaposi's sarcoma (KS) with second primary cancers, especially of the lymphoreticular system, has been frequently noted. To confirm these reports in a systematic way, data on a series of 92 patients with KS treated at Memorial Sloan-Kettering Cancer Center (MSKCC) 2949-1975 were subjected to extensive statistical analysis. Use was made also 4517 double primaries including all sites, diagnosed at MSKCC 1949-1974, and 1959 simultaneous double primaries from the Third National Cancer Survey. Some key results: (1) of KS patients had toher primary malignancies; (2) there was a 20-fold increase in the incidence of lymphoreticular malignancies after diagnosis of KS; (3) in the MSKCC series double primaries, lymphoreticular malignancies were involved in 8% of cases; for KS alone the corresponding figure was 58%. Our findings provide evidence in support of possible etiopathogenic mechanisms that may be involved in the natural course of KS.
D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000150:complications; D004812:Epidemiologic Methods; D005260:Female; D006689:Hodgkin Disease / Q000209:etiology; D006801:Humans; D007938:Leukemia / Q000209:etiology; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000209:etiology*; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000209:etiology*; D014481:United States