The presence of normal levels of serum immunoreactive insulin-like growth factor 2 (IGF-2) in patients with Down's syndrome.
The present study was performed to further investigate the levels of somatomedins in Down's syndrome (DS). The results show that the serum levels of immunoreactive insulin-like growth factor 2 (RIA-IGF-2) in patients with DS is within the normal adult range. No age variation among the patients was observed. Since we earlier reported a deficiency of immunoreactive insulin-like growth factor 1 (IGF-1) in DS patients, present study showing normal RIA-IGF-2 levels suggests a selective deficiency of IGF-1 in DS.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D004314:Down Syndrome / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007223:Infant; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D011247:Pregnancy; D011863:Radioimmunoassay; D013002:Somatomedins / Q000097:blood*
D007328:Insulin; D010455:Peptides; D013002:Somatomedins