Trauma affects cyclic AMP and DNA levels at injured and non-injured distal oral mucosal sites.
Experiments in rats were conducted to test the hypothesis that gingival trauma affects cyclic AMP and DNA levels at the gingival wound, and non-injured distal (gingival, palatal) sites. Cyclic AMP and DNA levels rose and fell in a cyclic fashion during the time (0.5-24 h) periods analyzed. Significant increases in cAMP levels occurred at 8 and 20 h and at 8 and 16 h, respectively, at the wound and non-injured palatal site, peripheral to the wound. Similar increases (not significant) in cAMP levels were also noted at the non-injured gingival contralateral site at the same time intervals. DNA distributions were found to be significantly greater 10 and 16 h after injury at the gingival wound, and distal non-injured gingival and palatal sites.
D000818:Animals; D000242:Cyclic AMP / Q000032:analysis*; D004247:DNA / Q000032:analysis*; D005881:Gingiva / Q000032:analysis; D008297:Male; D009061:Mouth Mucosa / Q000032:analysis / Q000293:injuries* / Q000473:pathology; D010159:Palate / Q000032:analysis; D051381:Rats; D013997:Time Factors
D004247:DNA; D000242:Cyclic AMP