Microneutalization of cytomegalovirus.
A simple microneutralization test for cytomegalovirus (CMV) is presented. Using a laboratory adapted stock virus, definite results were obtained after 10 days. All patients with primary CMV infection showed an antibody rise and/or seroconversion; however, neutralizing antibody appeared only seven weeks after the onset of clinical symptoms. In control patients without evidence of recent primary infection, there was a complete concordance of the presence of complement-fixing and neutralizing antibodies.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D003165:Complement System Proteins; D003587:Cytomegalovirus / Q000276:immunology*; D003588:Cytopathogenic Effect, Viral; D006168:Guinea Pigs; D006801:Humans; D009500:Neutralization Tests
D000914:Antibodies, Viral; D003165:Complement System Proteins