title: Effects of infectious bursal disease on Marek's disease vaccination: suppression of antiviral immune response.
abstract: Studies were made to determine whether infectious bursal disease virus (IBDV) infection would affect the response of chickens to turkey herpesvirus (HVT) vaccination in the development and level of HVT viremia and virus-neutralizing (VN) antibodies to HVT. The HVT viremia in the vaccinated chickens was not affected by IBDV, whether IBDV was inoculated simultaneously with HVT vaccination at one day of age or whether it was inoculated 3 weeks postvaccination with HVT. However, VN antibody response to HVT was significantly suppressed (P less than 0.001) when vaccinated chickens were exposed to IBDV either at the time of vaccination or at 3 weeks postvaccination. Such immunosuppression by IBDV of VN antibody response to HVT vaccination may result in a reduced antiviral immunity against Marek's disease virus.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002645:Chickens / Q000276:immunology*; D006564:Herpesviridae / Q000276:immunology / Q000302:isolation & purification; D007108:Immune Tolerance; D007243:Infectious bursal disease virus / Q000276:immunology; D008214:Lymphocytes / Q000382:microbiology; D008380:Marek Disease / Q000517:prevention & control*; D009500:Neutralization Tests; D011201:Poultry Diseases / Q000276:immunology*; D012088:Reoviridae Infections / Q000662:veterinary*; D014422:Turkeys; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral