[Analysis of the relationship between temperatures and the process of diaphragmatic cell membrane repolarization in rats of different ages].
The temperature dependence (TD) of the membrane repolarization process (RP) in muscle cells within the range of 10--20 degrees C following preliminary cooling of muscles, the effect of treatment of diaphragmatic muscles (DM) with ouabain (Ou) (10(-4) M) and administration of 2,4-dinitrophenol (2,4-DNP) (1.5 mg/100g) on RP were studied in experiments on isolated DM of adult (7--8-month-old) and old (28--32-month-old) male white rats. Ou and 2,4-DNP decrease the temperature coefficient Q10 of cell membrane RP of DM in the adult animals to the magnitudes approximating one, while in the old animals, 2,4-DNP does not change TD of RP and Ou reduces it from 3.824 +/- 0.440 but to 2.725 +/- 0.245. A possible age-associated reconstitution of the mechanisms of active transmembrane ion transport is suggested.
D000367:Age Factors; D000818:Animals; D003964:Diaphragm / Q000502:physiology*; D004140:Dinitrophenols / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology; D013696:Temperature
D004140:Dinitrophenols; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase
Analiz temperaturnoĭ zavisimosti protsessa repoliarizatsii membran kletok diafragmal'noĭ myshtsy krys razlichnogo vozrasta.