[Adrenoreceptor-independent effect of thyroxine and adrenoxyl on myocardial adenyl cyclase activity and cAMP levels].
A study was made of the effect of different concentrations of noradrenaline, adrenaline, adrenoxyl (stabilized adrenochrome) and thyroxin on the adenylate cyclase activity and cAMP content in the myocardium of intact animals and in neurogenous affections of the myocardium. It was shown that the content of cAMP in the myocardium drops in neurogenous affections and that thyroxin or adrenoxyl in combination with beta-adrenoblockers (propranolol) might be used for the recovery of the cAMP content and adenylate cyclase activity.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000323:Adrenochrome / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D009202:Cardiomyopathies / Q000378:metabolism*; D000242:Cyclic AMP / Q000032:analysis*; D006321:Heart / Q000294:innervation; D009206:Myocardium / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
D000323:Adrenochrome; D011433:Propranolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D013974:Thyroxine
Nezavisimoe ot adrenoretseptsii vozdeĭstvie tiroksina i adrenoksila na aktivnost' adenilattsiklazy i uroven' tsAMF v miokarde.