Tonic analgesic effects of delta 9-tetrahydrocannabinol as measured with the formalin test.
The analgesic effects of delta 9-tetrahydrocannabinol (THC), the psychoactive component of marihuana, were tested using the formalin test. Rats were treated with either THC (5 mg/kg or 10 mg/kg) or a placebo by gavage 4 h before the formalin test for analgesia was initiated. THC produced a highly significant analgesic effect against both phasic pain and tonic pain. THC is discussed as a model for the development of new analgesics or as a suitable analgesic if used with another potentiating drug.
D000700:Analgesics; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D013759:Dronabinol / Q000494:pharmacology*; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology*; D008297:Male; D010146:Pain / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D013997:Time Factors
D000700:Analgesics; D005557:Formaldehyde; D013759:Dronabinol