Assessment of acyclovir on acute ocular infection induced by drug-resistant strains of HSV-1.
Effects of topical acyclovir treatment on rabbit eyes infected with parent McKrae, idoxuridine-resistant, and vidarabine-resistant strains of HSV-1 were studied. Topical acyclovir therapy given four times a day was significantly more effective than idoxuridine and vidarabine at suppressing acute herpetic ocular disease induced by either sensitive or drug-resistant strains of HSV-1. Virus isolation from neural tissues indicated that none of the therapy prevented viral infection of the nervous system.
D000212:Acyclovir; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D004352:Drug Resistance, Microbial; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007065:Idoxuridine / Q000008:administration & dosage; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D008297:Male; D009824:Ointments; D009883:Ophthalmic Solutions; D011817:Rabbits; D018139:Simplexvirus / Q000302:isolation & purification; D014740:Vidarabine / Q000008:administration & dosage; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D009824:Ointments; D009883:Ophthalmic Solutions; D006147:Guanine; D014740:Vidarabine; D007065:Idoxuridine; D000212:Acyclovir