Activation of lymphocytes from Epstein-Barr virus-seronegative donors by autologous Epstein-Barr virus-transformed cells.
The activation of peripheral lymphocytes by Epstein-Barr virus (EBV)-transformed cells was tested in the autologous system. EBV-transformed cells activated autologous lymphocytes from all 10 healthy subjects regardless of their status of antibody to EBV. Lymphocytes from three neonates were also activated by autologous EBV-transformed cells. It was concluded that activation of lymphocytes by autologous EBV-transformed cells is a nonspecific phenomenon in the sense that prior infection by EBV is not a prerequisite for responsiveness of lymphocytes to autologous EBV-transformed cells. The responding cells were found predominantly in the T cell-enriched fraction. This finding is of no interest because the pathogenesis of, and recovery from, infectious mononucleosis may depend in part on this nonspecific phenomenon.
D000293:Adolescent; D000328:Adult; D002472:Cell Transformation, Viral; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008937:Mitomycins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D008937:Mitomycins; D013936:Thymidine