Ocular toxicity of topical antifungal agents.
We studied, in a rabbit, the ocular toxicity of topical 1% solutions or suspensions of amphotericin B, flucytosine, miconazole nitrate, and ketoconazole. Flucytosine, miconazole, and ketoconazole did not retard the closure of 8.5-mm corneal epithelial defects; amphotericin B greatly retarded the closure of such defects. Amphotericin B produced dramatic pathologic changes in this model; these changes worsened with each day of therapy. Ketoconazole produced modest biomicroscopically and histologically detectable pathologic changes in the regenerating corneal epithelium; flucytosine and miconazole did not produce such changes.
D000287:Administration, Topical; D000666:Amphotericin B / Q000009:adverse effects; D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects; D005123:Eye / Q000187:drug effects*; D005437:Flucytosine / Q000009:adverse effects; D007093:Imidazoles / Q000009:adverse effects; D007500:Iritis / Q000139:chemically induced; D007654:Ketoconazole; D008825:Miconazole / Q000009:adverse effects; D010879:Piperazines / Q000009:adverse effects; D011817:Rabbits
D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D008825:Miconazole; D000666:Amphotericin B; D005437:Flucytosine; D007654:Ketoconazole