[Mechanism of activating action of ATP on repair synthesis of DNA in chromatin].
The mechanism of activating action of ATP on the repair synthesis of DNA was studied in the chromatin isolated from rat liver (G0). It was shown that chromatin catalyzed the conversion dNTP leads to dNDP leads to dNMP leads to NdR. The principal mechanism of activating action of ATP is the maintenance of dNTP levels. The maintenance is carried out mainly by the inhibition of dNTP's phosphatases and in less extent by the means of reaction dNDP leads to dNTP. Besides that, ATP partially suppresses 3' leads to 5' exonuclease of chromatin which degrades the nascent DNA. The activating action of ATP is connected neither with phosphorylation of histones, nor with the activities of ATP-dependent endo- or exonucleases, DNA gyrase, polynucleotide ligase, or DNA unwinding protein.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis*; D004265:DNA Helicases / Q000378:metabolism; D011088:DNA Ligases / Q000378:metabolism; D004260:DNA Repair; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D012265:Ribonucleotides / Q000378:metabolism
D002843:Chromatin; D012265:Ribonucleotides; D000255:Adenosine Triphosphate; D004247:DNA; D004265:DNA Helicases; D004250:DNA Topoisomerases, Type II; D011088:DNA Ligases
Mekhanizm aktiviruiushchego deistviiv ATP na reparativnyĭ sintez RNK v khromatine.