In vivo effect of three transformation-defective mutants of subgroup C avian sarcoma viruses.
Three transformation-defective mutants derived from avian sarcoma viruses of subgroup C, td PR-RSV-C (Vogt), td B77 (Toyoshima) and td daPR-RSV-C (isolated in our laboratory), were injected intravenously into 12-day-old chicken embryos and intraperitoneally into newly-hatched chickens. Both Brown Leghorn chickens and F1 hybrids of two inbred chicken lines (C X I) were used. Haematological changes and formation of visible tumours were evaluated in animals kept for 8-9 months. All three td mutants produced in a significant proportion of intraembryonally injected animals haematological disorders which, in certain cases, resembled the anaemic and proliferative type of erythroblastosis. Most conspicuous symptoms of erythroblastosis were seen after td daPR-RSV-C which also gave rise to two sarcomas, containing transforming viruses. The possible character of oncogenic information retained or acquired by the TD mutants is discussed.
D000740:Anemia / Q000209:etiology / Q000662:veterinary; D000818:Animals; D001353:Avian Leukosis / Q000209:etiology; D001358:Avian Sarcoma Viruses / Q000235:genetics / Q000472:pathogenicity*; D001772:Blood Cell Count; D002472:Cell Transformation, Viral; D002642:Chick Embryo; D002645:Chickens; D004900:Erythroblasts / Q000473:pathology; D006403:Hematologic Tests; D009154:Mutation; D001357:Sarcoma, Avian / Q000097:blood / Q000209:etiology / Q000473:pathology