[Response of splenic lymphocytes to phytohemagglutinin and bacterial lipopolysaccharide in mice, sensitive and resistant to mouse hepatitis virus 3 (MHV3)].
The responsiveness of splenic cells to phytohemagglutinin but not to bacterial endotoxin was inhibited during MHV3 infection of both sensitive (C57Bl6) and resistant (A/J) Mice. This result could be interpreted as the consequence of an inhibition that selectively affects the T lymphocytes during infection. In C57Bl6 sensitive Mice the inhibition could be a consequence of the destruction of splenic T lymphocytes. In A/J resistant Mice, no splenic lesions have been observed; therefore another mechanism must be considered in order to explain the inhibition of the responsiveness of splenic cells to phytohemagglutinin.
D000818:Animals; D006524:Hepatitis, Viral, Animal / Q000276:immunology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008099:Liver / Q000382:microbiology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D006517:Murine hepatitis virus; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000382:microbiology
D008070:Lipopolysaccharides; D010835:Phytohemagglutinins
Etude de la réponse des lymphocytes spléniques à la phytohémagglutinine et au lipopolysaccharide bactérien chez les Souris sensibles et résistantes au virus de l'hépatite murine 3 (MHV3).