[Substances with antiviral. XVI. Thiosemicarbazones containing benzofuran and 1H-indene moieties].
A few hydrazones with benzofuran and 1H-indene moieties were synthesized and screened in vitro against vaccinia virus strain IHD, parainfluenza type 3 virus strain HA-1/CR-8, and the MP mutant of herpes simplex virus type 1 [HSV-1 (MP)]. Only the thiosemicarbazones were active. The thiosemicarbazone of 3-chloro-2-formyl-1H-indene inhibited vaccinia virus to a greater extent than methisazone, used as reference standard. Furthermore, this compound was active also against parainfluenza and herpes viruses.
D000998:Antiviral Agents / Q000138:chemical synthesis*; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014616:Vaccinia virus / Q000187:drug effects
D000998:Antiviral Agents; D013882:Thiosemicarbazones
Ricerche su sostanze ad attività antivirale. Nota XVI--Tiosemicarbazoni contenenti unità benzofuranica e 1H-indenica.