Dimethyl sulfoxide inhibits killing of Staphylococcus aureus by polymorphonuclear leukocytes.
Increasing concentrations of the highly permeable, hydroxyl radical scavenger dimethyl sulfoxide progressively decreased killing of Staphylococcus aureus 502A by human polymorphonuclear leukocytes; methane, a product of the reaction of the hydroxyl radical with dimethyl sulfoxide, was generated in the process.
D001770:Blood Bactericidal Activity / Q000187:drug effects*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008697:Methane / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D013211:Staphylococcus aureus / Q000254:growth & development*; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D008697:Methane; D004121:Dimethyl Sulfoxide