beta-Endorphin: hyperthermia in mice by intravenous injection.
Effects of intravenous beta-endorphin on body temperature and body weight loss were studied in naive and morphine-dependent mice. beta-Endorphin at doses 2.6-25.5 mg/kg injected intravenously caused hyperthermia in naive mice as well as in morphine-dependent mice. In addition, beta-endorphin and morphine reduced body-weight loss during the morphine withdrawal.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D005334:Fever / Q000139:chemically induced*; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin; D009020:Morphine