The glucagonoma syndrome. Report of a case.
A 73-year-old man had diabetes mellitus, diarrhea, weight loss, and a rash of several years' duration. The rash, termed necrolytic migratory erythema, was the most characteristic feature and eventually suggested the diagnosis of a glucagon-secreting tumor of the pancreas. Diabetic ketoacidosis also developed in our patient, a previously unrecognized occurrence with this syndrome.
D007516:Adenoma, Islet Cell / Q000175:diagnosis* / Q000378:metabolism; D000368:Aged; D003920:Diabetes Mellitus / Q000209:etiology; D004890:Erythema / Q000209:etiology; D005934:Glucagon / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis*
D005934:Glucagon