[Effect of stimulator substances on the contractile activity of the isolated rat myometrium against a background of various calcium permeability blockaders].
Contractile effects of oxytocin, prostaglandin F2 alpha, acetylcholine, KCl, RbCl, and BaCl2 in the presence of Mn2+ and La3+ ions and other cations were studied in the rat myometrium at 37 degrees C. The effects depended mainly on the kind of the blocking agents (oxytocin in the presence of Mn2+ significantly increased muscle tone whereas in the presence of La3+, Cd2+, Mg2+ the effect was absent). The tone increase in the presence of Ca permeability blocking agents seems to be due to the effect of the agents on the intracellular sources of Ca ions.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002415:Cats; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002712:Chlorides / Q000494:pharmacology; D004971:Estrus / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects; D007811:Lanthanum / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D009566:Nitrates / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013431:Sulfates / Q000494:pharmacology; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects*
D002712:Chlorides; D007473:Ion Channels; D009566:Nitrates; D011461:Prostaglandins F, Synthetic; D013431:Sulfates; D008345:Manganese; D010121:Oxytocin; D007811:Lanthanum; D000109:Acetylcholine; D002118:Calcium
Vliianie veshchestv-stimuliatorov na sokratitel'nuiu aktivnost' izolirovannogo miometriia krys na fone razlichnykh blokatorov kal'tsievoĭ pronitsaemosti.