title: Electrophysiological analysis of taurine and glycine action on neurons of the mudpuppy retina.  II. ERG, PNR and Müller cell recordings.
abstract: Extracellular electrophysiological recordings of the electroretinogram (ERG) and proximal negative response (PNR) were carried out in the perfused retina-eyecup prepartation of the mudpuppy. Intracellular recordingws were obtained from Müller cells. Bath-applied taurine/glycine had identical effects on the ERG, PNR and Müller cell responses and the effects of both agents were blocked by strychnine. Taurine and glycine suppressed the d-wave of the ERG, the OFF response of Müller cells and ON and OFF responses of the PNR. These observations show that taurine/glycine sensitivity is predominantly found in the OFF channel of the ERG whose underlying neuronal basis appears to be dark evoked depolarization of OFF bipolars.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography; D005071:Evoked Potentials / Q000187:drug effects; D005998:Glycine / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D012160:Retina / Q000166:cytology / Q000187:drug effects*; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D013654:Taurine / Q000494:pharmacology*
chemical_list: D013654:Taurine; D013331:Strychnine; D005998:Glycine