title: On some properties of a new steroid curare-like compound pipecurium bromide.
abstract: In experiments on cats it has been shown that 2 beta, 16 beta-bis (4'-dimethyl-1'-piperazino)-3 alpha, 17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, RGH-1106, Arduan), is a non-depolarizing muscular blocker. The order of myorelaxation evoked by this agent is characteristic: first the chewing and limb muscles, then abdominal muscles and diaphragm and at the end intercostal muscles are relaxed. Pipercurium bromide has no cardiotropic, atropine-like, or ganglion-blocking activity. It fails to influence the coronary blood-supply or myocardial oxygen consumption. No acetylcholinesterase inhibiting action of the compound was seen. It does not affect the central nervous system.
mesh_terms: D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000494:pharmacology*; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D004576:Electromyography; D005071:Evoked Potentials / Q000187:drug effects; D009125:Muscle Relaxants, Central; D009132:Muscles / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000494:pharmacology; D017300:Pipecuronium; D010879:Piperazines / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000732:Androstanols; D009125:Muscle Relaxants, Central; D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D011950:Receptors, Cholinergic; D017300:Pipecuronium; D015113:Androstane-3,17-diol; D010197:Pancuronium