Comparative effects of an inflammatory reaction on the resistance of mice to bacterial and viral infections.
The induction in mice of a sterile subcutaneous granuloma exerted no influence upon the mortality following their infection with herpes type 1, murine hepatitis or encephalomyocarditis viruses. Attempts to reproduce the resistance -- which has been found to occur as a result of the granulomatous reaction, in the case of bacterial, fungal or protozoa infections and tumour invasions -- by varying the route and timing of the virus inoculation or the strain of mice have failed. We conclude that it is not merely through their inflammatory properties that some non-specific immunostimulating substances enhance resistance against viral infection.
D000375:Aging; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D004686:Encephalomyocarditis virus / Q000276:immunology; D005260:Female; D005782:Gels; D006099:Granuloma / Q000139:chemically induced / Q000401:mortality; D007249:Inflammation / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology; D006517:Murine hepatitis virus / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*
D005782:Gels