[Effect of cGMP administration on certain metabolic processes in rat wound tissues].
Administration of cGMP immediately after an operation caused the early activations of collagen biosynthesis in skin, muscles and granulations. Within the 5 day content on collagen was increased two-fold in granulations of experimental animals as compared with controls. Stimulation of the label incorporation into some muscle proteins and intensification of glycogen metabolism were also observed after the cGMP treatment. Morphologic analysis of tissues and measurement of the wound area in dynamics of healing were carried out. The data obtained suggest that administration of cGMP into the operated animals activated metabolism in wound tissues and stimulated their healing.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D006152:Cyclic GMP / Q000494:pharmacology* / Q000627:therapeutic use; D005943:Gluconeogenesis; D006003:Glycogen / Q000378:metabolism; D006097:Granulation Tissue / Q000378:metabolism; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis; D009132:Muscles / Q000293:injuries / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000293:injuries / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy / Q000378:metabolism*
D009124:Muscle Proteins; D006003:Glycogen; D003094:Collagen; D006152:Cyclic GMP
Vliianie vvedeniia tsGMF na nekotorye metabolicheskie protsessy v tkaniakh rany krys.