Cyclic nucleotides and prostaglandins in psoriasis.
The changes in cAMP, cGMP, adenylate cyclase, cyclic phosphodiesterase, and prostaglandins in psoriatic epidermal cells were compiled and critically discussed. The results of the pertinent studies permit the assumption that therapeutic approaches in psoriasis via the system of cyclic nucleotides and prostaglandins might be promising.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005958:Glucosephosphates; D006801:Humans; D010428:Pentosephosphates / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010777:Photochemistry; D011453:Prostaglandins / Q000378:metabolism*; D011565:Psoriasis / Q000188:drug therapy / Q000378:metabolism*; D012867:Skin / Q000201:enzymology / Q000378:metabolism; D012880:Skin Pigmentation / Q000187:drug effects
D005958:Glucosephosphates; D010428:Pentosephosphates; D011453:Prostaglandins; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D006152:Cyclic GMP