title: Effects of hyperthermia on a neurogenic rat cell line (BT4C) in culture. Development of thermal tolerance during continuous heating.
abstract: The malignant neurogenic rat cell line BT4C developed tolerance to further heat injury after continuous heating in culture at 41.0 and 42.0 degrees C for 8 and 2 hours, respectively. Survival was evaluated by colony forming ability. The proliferative capacity of the surviving cells was reduced after heating as shown by a decrease in size of the colonies.
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy; D002460:Cell Line; D002470:Cell Survival; D003114:Colony-Forming Units Assay; D005260:Female; D006358:Hot Temperature; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy; D051381:Rats