Presence of ganglion cells in Wilm's tumours: a review of the possible neuroepithelial origin of nephroblastoma.
Twenty-seven cases of Wilms' tumour were reviewed in order to confirm the presence of nervous tissue which could imply a 'neuroepithelial' origin for these neoplasms. For this purpose a double-silver impregnation technique was used. Groups of ganglion cells with neurofibrils and non-myelinated axon-like processes appeared associated with a fine neurofibrillar network with neuromuscular junctions. Nervous tissue in nephroblastoma is mature and should not be confused with primary ganglioneuroblastoma of the kidney in which neuroblasts in rosette-like groupings are very numerous. A case report of such a lesion is discussed for purposes of comparison.
D001369:Axons / Q000648:ultrastructure; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D003593:Cytoplasm / Q000648:ultrastructure; D005724:Ganglia / Q000473:pathology*; D005729:Ganglioneuroma / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D009132:Muscles / Q000473:pathology; D009454:Neurofibrils / Q000648:ultrastructure; D009469:Neuromuscular Junction / Q000648:ultrastructure; D009396:Wilms Tumor / Q000473:pathology*