Pharmacological evidence for differences in the beta-adrenoceptor populations influencing atrial rate in guinea pig and cat.
The pA2 values of the selective beta-adrenoceptor antagonists, atenolol and alpha-methylpropranolol, have been assessed using the selective agonists, norepinephrine and fenoterol, as positive chronotropic agents in atria. In cat atria both beta 1- and beta 2-adrenoceptors influence atrial rate, whereas in guinea pig atria only beta 1-receptors are involved.
D000818:Animals; D001262:Atenolol / Q000494:pharmacology; D002415:Cats; D005280:Fenoterol / Q000494:pharmacology; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000031:analogs & derivatives; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D005280:Fenoterol; D001262:Atenolol; D011433:Propranolol; D009638:Norepinephrine