title: alpha-Actinin promotes polymerization of actin from profilactin.
abstract: The effect of alpha-actinin on profilactin has been analyzed. The results show that addition of submolar ratios of alpha-actinin to a profilactin sample leads to a dissociation by the profilin-actin complex and polymerization of actin. The newly formed filaments are cross-linked by alpha-actinin.
mesh_terms: D000185:Actinin / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D003432:Cross-Linking Reagents; D003850:Deoxyribonuclease I; D003851:Deoxyribonucleases / Q000037:antagonists & inhibitors; D004591:Electrophoresis, Polyacrylamide Gel; D004720:Endonucleases / Q000037:antagonists & inhibitors; D007700:Kinetics; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D051304:Profilins; D011506:Proteins / Q000378:metabolism*; D011817:Rabbits
chemical_list: D000199:Actins; D003432:Cross-Linking Reagents; D046911:Macromolecular Substances; D009124:Muscle Proteins; D051304:Profilins; D011506:Proteins; C024782:profilactin; D000185:Actinin; D003851:Deoxyribonucleases; D004720:Endonucleases; D003850:Deoxyribonuclease I