Effect of ketamine on transmission in sympathetic ganglia.
The effect of ketamine on sympathetic ganglion transmission has been studied using the guineapig isolated hypogastric nerve-vas deferens preparation. Ketamine produced a dose-dependent depression in the response to preganglionic stimulation (IC50 2.05 X 10--4 mol litre--1). No change in the response to postganglionic stimulation was recorded. The anti-cholinergic activity of ketamine was confirmed using the frog isolated rectus abdominis.
D000009:Abdominal Muscles / Q000187:drug effects; D000818:Animals; D001001:Anura; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005728:Ganglia, Sympathetic / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011189:Potassium Chloride / Q000494:pharmacology; D011896:Rana temporaria; D009435:Synaptic Transmission / Q000187:drug effects*
D006584:Hexamethonium Compounds; D011189:Potassium Chloride; D007649:Ketamine; D002217:Carbachol