title: Insertion of the eukaryotic transposable element Ty1 creates a 5-base pair duplication.
abstract: The his4-912 mutation results from insertion of a transposable element into the 5'-non-coding region of the his4 gene of yeast. A duplication of 5 base pairs of wild-type his4 DNA flanks the inserted element. The major class of His+ revertants result from excision of most of the transposable element, leaving an inserted segment of 334 base pairs flanked by the 5-base pair repeats.
mesh_terms: D001483:Base Sequence; D004251:DNA Transposable Elements; D004271:DNA, Fungal / Q000235:genetics*; D005057:Eukaryotic Cells / Q000502:physiology; D006639:Histidine / Q000235:genetics; D009154:Mutation; D009876:Operon; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D004271:DNA, Fungal; D006639:Histidine