Potency testing of killed polio vaccine in rats.
Various laboratory animal species were considered for testing the potency of killed poliovaccine. The rat appeared most suitable for obtaining quantitative information by measuring the titre of the antibody response. There was, in general, a good correlation between antibody response in rats and D-antigen titre. This relationship appeared less clear for heat-degraded or long-stored vaccines.
D000818:Animals; D000917:Antibody Formation; D000956:Antigens, Viral / Q000032:analysis*; D006168:Guinea Pigs; D006801:Humans; D017955:Poliovirus / Q000276:immunology*; D011054:Poliovirus Vaccine, Inactivated / Q000592:standards*; D051381:Rats; D011919:Rats, Inbred Strains; D014774:Virulence
D000956:Antigens, Viral; D011054:Poliovirus Vaccine, Inactivated