[Effects of the dihydroxyl metabolites of vitamin D3 and their ethanol solvent on parathyroid secretion: in vivo study in the rat].
The regulation of parathyroid secretion by the vitamin D3 dihydroxylated metabolites was studied by differents authors. In vitro experiments showed that 1 alpha (OH)2 D3 and 24 R 25 (OH)2 D3 inhibited the PTH release. In Rats maintained in a normal calcium diet or calcium and/or vitamin D deficient diet, 1 alpha 25(OH)2 D3 and 24 R 25 (OH)2 D3 inhibited the PTH release, whereas 24 S 25 (OH)2 D3, 25 S 26 and 25 R 26(OH)2 D3 had no effect.
D000818:Animals; D002118:Calcium / Q000097:blood; D002762:Cholecalciferol / Q000378:metabolism* / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D006900:Hydroxylation; D010280:Parathyroid Glands / Q000187:drug effects / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood; D051381:Rats; D012997:Solvents
D010281:Parathyroid Hormone; D012997:Solvents; D002762:Cholecalciferol; D000431:Ethanol; D002118:Calcium
Effets des métabolites dihydroxyles de la vitamine D3 et de leur solvant éthanol sur la sécrétion parathyroïdienne: étude in vivo chez le rat.