[Changes in plasma prostaglandins in normal subjects in an orthostatic position. Comparison with the response of the renin-aldosterone system].
Changes in blood pressure, plasma concentrations of PGE2, PGF2 alpha, G-keto-PGF1 alpha, thromboxane B2, aldosterone and plasma renin activity were evaluated in 13 normotensive subjects passing from supine to upright position. Orthostatism resulted in slight elevation of blood pressure and increase of all plasma prostaglandins (except PGE2), plasma aldosterone and plasma renin activity. A positive correlation was found in supine position between systolic arterial pressure and thromboxane B2 level (p less than 0.001). In upright position, however, blood pressure did not correlate with any of the hormones assayed. Orthostatism is a powerful stimulant of renin and aldosterone secretion but not so much of prostaglandin secretion. Basal arterial pressure is significantly influenced by thromboxane A2.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture; D011453:Prostaglandins / Q000097:blood*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D012083:Renin / Q000097:blood*; D013929:Thromboxane B2 / Q000097:blood
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D000450:Aldosterone; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D012083:Renin
Modifications des prostaglandines plasmatiques chez les sujets normaux en orthostatisme. Comparaison avec la réponse du système rénine-aldostérone.