[Action of novobiocin on the capacity of Nocardia fructiferi var. ristomycini for ristomycin biosynthesis].
The effect of novobiocin in concentrations of 0.05 and 0.2--0.3 microgram/ml on morphological variation of N. fructifer and its capacity for ristomycin production was studied. It was found that the number of colonies with the maximum activity increased under the effect of novobiocin used in a concentration of 0.05 microgram/ml. An increase in the level of novobiocin in the medium up to 0.2--0.3. microgram/ml markedly increased the number of the colonies with low antibiotic productivity.
D004305:Dose-Response Relationship, Drug; D009615:Nocardia / Q000187:drug effects*; D009675:Novobiocin / Q000494:pharmacology*; D012310:Ristocetin / Q000096:biosynthesis*
D012310:Ristocetin; D009675:Novobiocin
Deĭstvie novobiotsina na sposobnost' Nocardia fructiferi var. ristomycini k biosintezu ristomitsina.