Effect of an iron-chelating agent on lymphocyte proliferation.
The effect of the iron-chelating agent desferrioxamine on lymphocyte proliferation has been studied. Desferrioxamine at concentrations of 15 microM totally inhibited the proliferation of Concanavalin A-stimulated lymphocytes, whereas iron-saturated desferrioxamine was ineffective. Other metal salts, however, had little or no effect on the inhibition induced by this drug. Desferrioxamine was more effective at suppressing proliferation of T lymphocytes than B lymphocytes and additionally suppressed mixed lymphocyte cultures and the generation of cytotoxic T cells.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D003676:Deferoxamine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008670:Metals / Q000494:pharmacology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D008070:Lipopolysaccharides; D008670:Metals; D003208:Concanavalin A; D007501:Iron; D003676:Deferoxamine