Immunological typing of acute lymphoblastic leukaemia patients in Singapore--a preliminary experience.
Six new patients with acute lymphoblastic leukaemia (ALL) have been studied with a battery of cell surface marker assays. These included T cell enumeration, B cell enumeration, monoclonal antibody studies for T cell subsets, (T helper cells, T suppressor cells and mature peripheral total T cells), HLA--DR (Ia-like antigens) and common ALL antigen. Three patients were found to have common ALL, 2 had null cell ALL and one had T cell ALL. Cytochemical studies on these 6 patients demonstrated a positive correlation between E rosette positivity and focal paranuclear staining with acid phosphatase. There appeared to be no correlation between FAB morphology and immunological subtype in the 6 patients studied.
D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000145:classification / Q000276:immunology*; D008215:Lymphocytes, Null / Q000276:immunology; D008297:Male; D015260:Neprilysin; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015260:Neprilysin