title: Calmodulin plays a pivotal role in cellular regulation.
abstract: The role of calcium ions (Ca2+) in cell function is beginning to be unraveled at the molecular level as a result of recent research on calcium-binding proteins and particularly on calmodulin. These proteins interact reversibly with Ca2+ to form a protein . Ca2+ complex, whose activity is regulated by the cellular flux of Ca2+. Many of the effects of Ca2+ appear to be exerted through calmodulin-regulated enzymes.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000494:Allosteric Regulation; D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002118:Calcium / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology*; D002450:Cell Communication; D000242:Cyclic AMP / Q000502:physiology*; D004789:Enzyme Activation; D010741:Phospholipases A / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D011955:Receptors, Drug / Q000502:physiology; D013329:Structure-Activity Relationship; D014336:Troponin / Q000502:physiology
chemical_list: D002135:Calcium-Binding Proteins; D002147:Calmodulin; D011955:Receptors, Drug; D014336:Troponin; D000242:Cyclic AMP; D011494:Protein Kinases; D010741:Phospholipases A; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D002118:Calcium