[Polycythaemia and uterine fibroma. A case with in vitro demonstration of an erythropoietic activity in the tumor (author's transl)].
A new case of polycythaemia associated with an uterine fibroma is presented. The presence of erythropoietin in the tumor has been demonstrated by an in vitro technique of titration using a microculture of foetal mouse liver cells. The study of 46 previously reported cases show that the usual pattern is that of an isolated polycythaemia occurring in a woman in her fifty and of a large fibroma. The surgical cure of the tumor relieves rapidly and definitively the polycythaemia. The hypothesis of an inappropriate secretion of erythropoietin seems admitted, three factors playing probably a role in the occurrence of the polycythaemia: size of the fibroma, state of the iron stores and presence of an inhibitory factor against erythropoiesis.
D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000150:complications*; D008875:Middle Aged; D011086:Polycythemia / Q000150:complications*; D014594:Uterine Neoplasms / Q000150:complications*
Polyglobulie et fibrome utérin. Mise en évidence in vitro d'une activité érythropoïétique dans l'extrait tumoral.