Synthesis and analgesic activity of human beta-endorphin analogs substituted at positions 17, 18, or 19.
Three peptide analogs of beta-endorphin which are substituted in positions 17, 18 or 19 have been synthesized and their analgesic potencies have been measured by the tail-flick method in mice. The results showed that the replacement of Phe-18 or Lys-19 by alanine reduced the potency to 15% whereas the replacement of Leu-17 by alanine reduced the analgesic potency to 68%.
D000595:Amino Acid Sequence; D000700:Analgesics; D000818:Animals; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D004590:Electrophoresis, Paper; D004723:Endorphins / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D010455:Peptides / Q000138:chemical synthesis; D013329:Structure-Activity Relationship; D001615:beta-Endorphin
D000700:Analgesics; D004723:Endorphins; D010455:Peptides; D001615:beta-Endorphin