Prediction of clinical course of bipolar manic depressive illness treated with lithium.
A group of bipolar manic depressive patients attending a routine lithium clinic were investigated. The results suggest that, when on treatment with lithium, manic depressive patients with a good prognosis tend to have a higher erythrocyte Na-K ATPase and higher plasma and erythrocyte lithium concentrations than those with a poor prognosis. There was no evidence to suggest that the erythrocyte: plasma lithium ratio was useful in predicting clinical response to lithium therapy. There was also a positive correlation between plasma lithium concentration and Na-K ATPase activity, confirming that in manic depressive subjects lithium produces a rise in erythrocyte Na-K ATPase activity.
D001714:Bipolar Disorder / Q000188:drug therapy* / Q000201:enzymology; D004573:Electrolytes / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D008094:Lithium / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D011379:Prognosis; D012008:Recurrence; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D004573:Electrolytes; D008094:Lithium; D000254:Sodium-Potassium-Exchanging ATPase