Phencyclidine-induced alterations of rat electrophysiology.
Phencyclidine (PCP) at high doses causes both excitation and depression in the rat. The visual evoked potential (VEP) was measured in rats following PCP administration in doses ranging from 1 mg/kg to 56 mg/kg. Consistent lengthening of VEP latencies suggests that PCP has an unusual inhibitory effect on visual function in the presence of the excitatory signs of bilaterally synchronous cortical spiking. The epileptogenic properties of PCP are quite evident in rats.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005074:Evoked Potentials, Visual / Q000187:drug effects; D008297:Male; D009115:Muridae; D010622:Phencyclidine / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced; D009435:Synaptic Transmission / Q000187:drug effects*; D014793:Visual Cortex / Q000187:drug effects
D010622:Phencyclidine