title: A new model for the study of opiate B-receptors: isolated splenic strip of the cat.
abstract: Noradrenergic neurotransmission in the electrically stimulated isolated splenic strip of the cat was found to be modulated via opiate receptor. Pharmacodynamic parameters of morphine, methionine-enkephalin, azidomorphine, naloxone and N-cyclopropylmethyl-norazidomorphine (CAM) were determined. As CAM proved to be more potent than naloxone in this organ, the cat splenic strip is a useful model for the in vitro testing of opiate B-receptors.
mesh_terms: D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008954:Models, Biological; D009019:Morphinans; D009022:Morphine Derivatives / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D009019:Morphinans; D009022:Morphine Derivatives; D011957:Receptors, Opioid; C006659:azidomorphine; D009270:Naloxone; C015097:N-cyclopropylmethylnorazidomorphine