[Effect of vasopressin on energy metabolism of the brain in adult and aged rats].
Content of adenosine phosphate, creatine phosphate, Pi, lactate and ATPase activity were studied in brain of 8-10- and 25-27-months old rats. Content of ATP and ADP and the Na+, K+-ATPase activity were decreased while the level of Pi was increased in rat brain cortex during ageing. Administration of vasopressin caused an increase in lactate, Pi and Na+, K+-ATPase activity, whereas creatine phosphate decreased in the adult rat hypothalamus. Changes in energy metabolism were more pronounced in old rats: simultaneously with the decrease in creatine phosphate and more marked, as compared with adults, increase in Pi and lactate, the content of ATP decreased, ADP and AMP - increased and the Na+, K+-ATPase was distinctly activated in stem and brain cortex.
D000227:Adenine Nucleotides / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000375:Aging; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology*
D000227:Adenine Nucleotides; D007773:Lactates; D010710:Phosphates; D010725:Phosphocreatine; D014667:Vasopressins; D000251:Adenosine Triphosphatases
Vliianie vazopressina na énergeticheskiĭ obmen golovnogo mozga vzroslykh i starykh krys.