title: Respiratory distress syndrome from lymphangiography contrast medium.
abstract: Adult respiratory distress syndrome (ARDS) has been reported as a rare complication of lymphangiography with ethiodized oil. We report 2 patients who developed otherwise unexplained pulmonary edema after lymphangiography, and describe an animal model of pulmonary injury after an injection of ethiodized oil. We injected 0.25 ml/kg of body weight intravenously into 45 rabbits, and followed arterial blood gases and/or killed the rabbits randomly at various intervals for morphologic lung examination by light and electron microscopy. Within 24 h after injection, there was moderate hypoxemia from oil embolization, but only minimal lung edema. However, by 2 to 4 days after injections, hypoxemia was most severe and was accompanied by extensive alveolar and interstitial inflammation, hemorrhage, and edema. After 4 days, there was gradual blood gas and morphologic recovery, with complete restoration of normal anatomy by 6 wk. Our data showed that in rabbits, ethiodized oil can reproducibly cause delayed, severe pulmonary injury, thus supporting the clinical reports that ARDS may occur several days after lymphangiography.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004998:Ethiodized Oil / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects; D008220:Lymphography / Q000009:adverse effects*; D008297:Male; D010100:Oxygen / Q000097:blood; D011650:Pulmonary Alveoli / Q000648:ultrastructure; D011817:Rabbits; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000473:pathology
chemical_list: D002245:Carbon Dioxide; D004998:Ethiodized Oil; D010100:Oxygen