A radioimmunoassay for pregnancy associated protein, beta 1SP1: levels in pregnancy, trophoblastic and neoplastic disease.
A radioimmunoassay system for the glycoprotein beta 1SP1, one of the pregnancy-associated proteins, has been set up. beta 1SP1 levels in normal pregnancy have been established transversally. Clearance (t1/2) from the circulation postpartum ranged from 1.4 to 1.8 days. Several patients with trophoblastic disease, e.g., mola hydatidosa, choriocarcinoma and embryonic cell carcinoma, were followed longitudinally. Human chorionic gonadotropin (hCG), a highly reliable tumor marker in trophoblastic disease, has been determined concomitantly by radioimmunoassay. In all instances, hCG proved to be a better indicator of the presence of a tumor, because by the time beta 1SP1 became undetectable, hCG could still be detected. Samples from a large multicenter study on trophoblastic disease were studied: out of 100 positive for hCG, beta 1SP1 could be detected in 86; however, out of 21 samples in which hCG was not detectable, 1 was found to be positive for beta 1SP1. In a number of samples from patients with bronchial carcinoma, no beta 1SP1 could be detected.
D001984:Bronchial Neoplasms / Q000378:metabolism; D002822:Choriocarcinoma / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000378:metabolism; D008137:Longitudinal Studies; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000378:metabolism*; D011863:Radioimmunoassay; D013724:Teratoma / Q000378:metabolism; D014328:Trophoblastic Neoplasms / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins