[Aggravation of acute galactosamine hepatitis by a sodic bicarbonated water in rats (author's transl)].
1. Acute galactosamine (Gal) hepatitis was induced in rats drinking ad libitum either sodic bicarbonated water of Vichy Grande Grille (GG) or ordinary tap water (OH2). Two series of experiments were performed. 2. In the first series, Gal-induced hepatitis was moderate. Twenty four hours after IP Gal injection, GG treated rats had relative to OH2 treated rats a decrease of bile flow and BSP excretion, and an increase of serum transaminase and bilirubin. Seven days after Gal the liver had returned to normal except for an increase in biliary bilirubin and liver total lipids. 3. In the second series, Gal-induced hepatitis was severe. Twenty four hours after galactosamine administration, an increase in mortality after anesthesia was found in Gal/GG rats. An increase of liver size and total hepatic lipids was also observed, while bile secretion, BSP excretion, cyt P 450 and ARN decreased in Gal/GG rats. Steatosis and inflammatory reactions were more important in Gal/GG than in Gal/OH2 rats. Most parameters came back to their normal levels in two days in Gal/OH2 rats, while 7 days were generally necessary in Gal/GG treated animals. Hepatic DNA kept increasing in Gal/GG animals and was still higher after 7 days, maybe due to a greater inflammatory reaction in the liver, maybe following a stimulated hepatocyte regenerative response. 4. These results indicate that GG water is not an inoffensive salt solution.
D000818:Animals; D001628:Beverages / Q000633:toxicity*; D001639:Bicarbonates / Q000633:toxicity*; D001663:Bilirubin / Q000378:metabolism; D002253:Carbonated Beverages / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D004357:Drug Synergism; D004798:Enzymes / Q000097:blood; D005688:Galactosamine / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D008297:Male; D009696:Nucleic Acids / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D004798:Enzymes; D009696:Nucleic Acids; D005688:Galactosamine; D017693:Sodium Bicarbonate; D001663:Bilirubin
Aggravation des lésions aiguës de l'hépatite à la galactosamine par une eau bicarbonatée sodique chez le rat.