[Combined Wilms' tumor therapy (author's transl)].
From 1967 to 1979, 40 children with Wilms' tumor were given a therapy comprising irradiation, operation and chemotherapy. Till 1972 preoperative irradiation was performed delivering a dose of 20 Gy followed by operation and actinomycin-D. The postoperative irradiation dose was 20 or 30 Gy. Of 22 patients died 7. Since 1973, therapy depends on age and tumor volume and consists in a combination of multidrug therapy, operation and irradiation (25 to 35 Gy). Of 19 children, 18 are still alive. No irradiation was given to patients younger than 1 year in stages I and II and to older children in stage I.
D002648:Child; D002675:Child, Preschool; D003609:Dactinomycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011182:Postoperative Care; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D009396:Wilms Tumor / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
D003609:Dactinomycin
Kombinierte Wilms-Tumor-Therapie.