ACTH4--10 affects behavior but not plasma corticosterone levels in a conditioned taste aversion situation.
Rats injected with LiCl after they consumed a sweetened milk solution subsequently avoided the milk. ACTH4--10 injection prior to a retention test for the aversion augmented the behavioral measure of the aversion. Rats consuming milk paired earlier with LiCl showed elevated plasma levels of corticosterone. The augmented avoidance response in ACTH4--10 injected rats was not paralleled by an augmented pituitary-adrenal response.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood*; D004327:Drinking Behavior / Q000187:drug effects*; D008297:Male; D008892:Milk; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D013649:Taste; D014867:Water
D010446:Peptide Fragments; D014867:Water; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10); D003345:Corticosterone