Involvement of brain monoamines in the delta-9-tetrahydrocannabinol-induced reduction of hippocampal choline uptake.
The role of monoamines in the transsynaptic reduction of neuronal activity produced by delta 9-tetrahydrocannabinol (delta 9-THC) in the septal-hippocampal cholinergic pathway has been investigated. Serotonergic afferents were chemically lesioned by unilateral infusion of 5,7-dihydroxytryptamine. Noradrenergic and dopaminergic inputs were selectively deleted by unilateral infusion of 6-hydroxydopamine into appropriate anatomic sites. Although removal of serotonergic and noradrenergic input did not alter hippocampal choline uptake relative to the contralateral control side, dopaminergic input reduction produced a significant elevation. After administration of delta 9-THC (20 mg/kg), reduction of choline uptake into lesioned hippocampi was not significantly different from that for the controls. These results indicate that monoaminergic afferents do not play a major role in the effect of delta 9-THC on cholinergic activity in the rat hippocampus.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002794:Choline / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D003714:Denervation; D004298:Dopamine / Q000502:physiology*; D013759:Dronabinol / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology; D007700:Kinetics; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism
D006892:Hydroxydopamines; D015116:5,7-Dihydroxytryptamine; D013759:Dronabinol; D002794:Choline; D004298:Dopamine; D009638:Norepinephrine