Studies of tumor implants in immunologically privileged sites.
Wilms' tumor, renal cell carcinoma, and neuroblastoma in animals were transplanted from donors to recipients with strong histocompatibility differences. No strong evidence of the privileged site theory was found in this study and no obvious evidence of an immunosuppressive effect of testosterone was found. The most important factor noted in these studies was that the take of tumor transplant seems to be related more to the type of tumor itself. Further studies of transplant results of such different types of tumors are warranted and are being conducted. An interaction between the hormonal supportive concept and the privileged site seems tenable.
D000230:Adenocarcinoma / Q000276:immunology; D000818:Animals; D001921:Brain / Q000276:immunology; D004958:Estradiol / Q000494:pharmacology; D005123:Eye / Q000276:immunology; D006085:Graft Survival / Q000187:drug effects; D006648:Histocompatibility; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology*; D009447:Neuroblastoma / Q000276:immunology; D011467:Prostate / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF; D013737:Testis / Q000276:immunology; D013739:Testosterone / Q000494:pharmacology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D009396:Wilms Tumor / Q000276:immunology
D013739:Testosterone; D004958:Estradiol