[Adenylate cyclase system and structural modifications of nuclear proteins in organisms radioprotection].
The paper deals with modern ideas of ways and mechanisms for realization of the radioprotector antiradiation effect. The data on the effect of biogenic amines (serotonin in particular) and radiation on the cAMP system are analyzed. It is shown that one of the most important mechanisms of the radioprotective effect is realized by changing the levels of histones and nonhistone proteins modifications through the adenylate cyclase system which leads to regulation of the chromatin template activity.
D000262:Adenylyl Cyclases / Q000378:metabolism* / Q000528:radiation effects; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology; D002843:Chromatin / Q000378:metabolism / Q000528:radiation effects; D000242:Cyclic AMP / Q000528:radiation effects*; D009698:Nucleoproteins / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology; D013698:Templates, Genetic
D001679:Biogenic Amines; D002843:Chromatin; D009698:Nucleoproteins; D012701:Serotonin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases
Adenilattsiklaznaia sistema i strukturnye modifikatsii iadernykh belkov pri zashchite organizma radioprotektorami ot luckevogo porazheniia.