A possible circulating plasma factor in Duchenne muscular dystrophy.
Basal (Na+, K+)AtPase activity was found to be significantly reduced in erythrocyte ghosts from patients with Duchenne muscular dystrophy, and, whereas ouabain inhibited enzyme activity in controls, it stimulated activity in patients. Prior incubation of normal erythrocyte ghosts in Duchenne plasma resulted in an increase in enzyme activity on subsequent exposure to ouabain. This suggests there may be a "circulating plasma factor" in Duchenne muscular dystrophy responsible for the abnormal response to ouabain. This "factor" was rendered inactive by dialysis or deproteination of the plasma.
D001798:Blood Proteins; D004910:Erythrocyte Membrane / Q000201:enzymology; D006801:Humans; D009136:Muscular Dystrophies / Q000097:blood*; D010042:Ouabain / Q000494:pharmacology; D012016:Reference Values; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D001798:Blood Proteins; C030635:DMD circulating plasma factor; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase