Aspects of parietal cell biology: cells and vesicles.
Many features of these gastric vesicles satisfy the requirements for the gastric H+ pump. For example, we have: (a) K+ requirement, (b) KA for K+ of about 30 mM; (c) identical cation sequence for tissue and vesicles, (d) similar anion sequence, (e) localization at the microvillus of the secretory canaliculus, (f) TI+ inhibiting H+ transport of both systems, and (g) the K+ gradient satisfying the osmotic gradient requirement for HCl-flow out of the parietal cell. Points that require explanation are lack of SCN- effects and regulation of KCl permeability.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D001693:Biological Transport, Active; D002462:Cell Membrane / Q000648:ultrastructure; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D011188:Potassium / Q000378:metabolism / Q000502:physiology; D011522:Protons; D013270:Stomach / Q000166:cytology* / Q000648:ultrastructure
D011522:Protons; D000251:Adenosine Triphosphatases; D011188:Potassium