Testosterone effect on experimental diabetes mellitus in encephalomyocarditis (EMC) virus infected mice.
A diabetes mellitus-like disease occurs in male DBA/2 mice infected with the M variant of the encephalomyocarditis virus. Female mice of this strain sustain systemic infection, but rarely exhibit hyperglycaemia. The diabetogenic effects of the virus were studied in 3 groups of adult DBA/2 males-castrates, castrates treated with testosterone, and sham-operated controls. After infection, pancreatic insulin concentrations decreased precipitously to approximately 10% of control values in intact males and castrates treated with testosterone; hyperglycaemia occurred concomitantly in both groups. In contrast, untreated castrates failed to develop hyperglycaemia and the effect on the insulin content of the pancreas was less striking.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002369:Castration; D003921:Diabetes Mellitus, Experimental / Q000382:microbiology / Q000503:physiopathology*; D004686:Encephalomyocarditis virus; D007328:Insulin / Q000032:analysis; D007515:Islets of Langerhans / Q000032:analysis; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D013739:Testosterone / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone