Opiate receptor binding in the brain of the hypertensive rat.
Experimental and genetic hypertension in male rate is accompanied by a lower specific [3H]naloxone binding in the dorsal horn of the spinal cord, and in the hippocampus as compared to controls. Rats which are genetically resistant to hypertensive stimuli have a higher specific [3H]naloxone binding in the nucleus tractus solitarius and lower opiate receptor binding in the dorsal horn. Together with previous studies which demonstrated a correlation between blood pressure and pain sensitivity, these results support the notion that specific brain loci participate in co-regulation of pain perception and blood pressure.
D000818:Animals; D001284:Atrophy; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006977:Hypertension, Renal / Q000378:metabolism*; D007668:Kidney / Q000473:pathology; D007700:Kinetics; D008297:Male; D009270:Naloxone / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D011957:Receptors, Opioid; D009270:Naloxone