Cyclic AMP induces a voltage-dependent current in neurones of Aplysia californica.
A voltage-dependent inward current is elicited by intracellular application of cyclic AMP in some neurons of Aplysia. The current has a slow time course and is present only at potentials more depolarized than -30 mV. Two other methods of increasing cellular cyclic AMP (phosphodiesterase inhibitors and sodium fluoride activation of adenylate cyclase) also induce an inward current at depolarized potentials.
D000818:Animals; D001048:Aplysia; D000242:Cyclic AMP / Q000494:pharmacology*; D004553:Electric Conductivity; D005724:Ganglia / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D012969:Sodium Fluoride / Q000494:pharmacology
D012969:Sodium Fluoride; D000242:Cyclic AMP