Induction of differentiation of human null cells into T lymphocytes under the influence of serum of mice treated with sodium diethyldithiocarbamate.
Mouse serum collected 24 hr after administration of sodium diethyldithiocarbamate was shown to convert a subset of null cells, not bearing the human T lymphocyte differentiating antigen (HTLA cells) into HTLA+ cells in man. In addition to inducing surface characteristics of T lymphocytes, the serum of treated mice increased functional activities of human peripheral blood lymphocytes, including the response to Con A and the suppressor activity in vitro.
D000818:Animals; D000954:Antigens, Surface; D001790:Blood Physiological Phenomena; D002454:Cell Differentiation / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D013045:Species Specificity; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory; D013859:Thiocarbamates / Q000494:pharmacology*
D000954:Antigens, Surface; D013859:Thiocarbamates; D003208:Concanavalin A; D004050:Ditiocarb