[Mammary Paget's disease: an ultrastructural study (author's transl)].
A case of mammary Paget's disease has been studied under electron microscopy. It seems that Paget's cells are coming from the basal layer which is not affected by the malignant proliferation. Paget's cells show some characters of keratinocytes such as rudimentary desmosomes and tonofilaments. But the tumoral tissue is very loose. The Paget's cells are not keratinised; they present numerous vesicles as malignant cells of apocrin mammary carcinoma. There are numerous histogenetic theories of Paget's disease. One of them sounds very interesting: it consists in looking for associations between microscopic mammary Paget's disease and mammary apocrin carcinoma.
D000368:Aged; D001943:Breast Neoplasms / Q000648:ultrastructure*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D008928:Mitochondria / Q000648:ultrastructure; D010144:Paget's Disease, Mammary / Q000648:ultrastructure*
Maladie de Paget du mamelon. Etude ultrastructurale.