Effect of syngeneic bone marrow and thymus cell transplantation to 90Sr irradiated mice.
Mice irradiated with 90Sr in doses of 14.8 and 25.9 kB/q/g body weight were given bone marrow or thymic cells intravenously at monthly intervals, or in single doses at 120 or 170 days after injection of 90Sr. At the low dose level a high incidence of lymphoreticular tumours in all cell treated groups occurred as compared with animals irradiated with 90Sr only. At the high dose level only the bone marrow transplanted group contracted a high incidence of lymphoreticular neoplasia. Furthermore, a somewhat decreased osteosarcoma incidence in the cell transplanted animals appeared to be indicated. However, the results obtained are inconsistent and difficult to evaluate. Therefore, it seems necessary to repeat the experiments, if more precise conclusions should be possible to draw.
D000818:Animals; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D005260:Female; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012516:Osteosarcoma / Q000453:epidemiology / Q000209:etiology*; D011829:Radiation Dosage; D013326:Strontium Radioisotopes / Q000008:administration & dosage; D013950:Thymus Gland / Q000166:cytology / Q000637:transplantation*; D013997:Time Factors; D014185:Transplantation, Isogeneic
D013326:Strontium Radioisotopes