[Activity of non-specific T-suppressors regulating the proliferation of B- and T-lymphocytes in patients with fibroadenomatosis, breast cancer and stomach cancer].
A decrease in proliferative rate of blood-circulating lymphocytes in response to LPS and PHA was registered in patients with fibroadenomatosis and cancer of the breast and stomach cancer. The said cells preincubated with Concanavalin A showed a weak inhibitory action on B-cells. The inhibition of T-cell proliferation by lymphocytes either remained unchanged or became less apparent in stage II breast cancer and slightly increased in stage III gastric cancer. Since no correlation was established between proliferative levels of T- and B-lymphocytes, two separate subpopulations of non-specific lymphocytes (T-T and T-B) were suggested.
D001402:B-Lymphocytes / Q000276:immunology; D001943:Breast Neoplasms / Q000276:immunology*; D005348:Fibrocystic Breast Disease / Q000276:immunology*; D006801:Humans; D007157:Immunologic Surveillance; D008213:Lymphocyte Activation; D008934:Mitogens / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D008934:Mitogens
Aktivnost' nespetsificheskikh T-supressorov, kontroliruiushchikh proliferatsiiu B- i T-limfotsitov, u bol'nykh fibroadenomatozom, rakom molochnoĭ zhelezy i zheludka.