[Thermoinduced structural changes in the membranes of animal organs following administration of antioxidants and during growth of malignancies].
By means of weak-bound spin probes--stable iminoxyl free radicals differing in the level of hydrophobity there were studied thermoinduced structural transitions in the membranes of cell organells of animal liver after intraperitoneal injection of antioxidants and in the course of malignant growth, and in the nuclear membranes of Ehrlich ascite carcinoma as well. It has been found that during the growth of Ehrlich ascite carcinoma changes in rotationary mobility of probes in cell nuclei isolated from the liver of tumour-carrying animal are similar to the changes observed after antiocidants injection. A different pattern is observed in tumour cells. The membranes of ascite cell nuclei are characterized by a weak dependence of tau c on temperature for both probes. Within the temperature range studied no characteristic structural transitions proceeding in the nuclei of intact animals are observed.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002467:Cell Nucleus / Q000187:drug effects*; D004578:Electron Spin Resonance Spectroscopy; D007425:Intracellular Membranes / Q000378:metabolism*; D008099:Liver / Q000648:ultrastructure; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D010847:Picolines; D011725:Pyridines / Q000494:pharmacology*; D013696:Temperature
D000975:Antioxidants; D008563:Membrane Lipids; D008565:Membrane Proteins; D010847:Picolines; D011725:Pyridines; D002084:Butylated Hydroxytoluene; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Issledovanie termoindutsirovannykh strukturnykh perekhodov v membranakh organov zhivotnykh pri vvedenii im antioksidantov i zlokachestvennom roste.