Lack of adenosine-3',5'-monophosphate receptor protein and apparent lack of expression of adenosine-3',5'-monophosphate functions in Mycobacterium smegmatis CDC 46.
The presence of adenosine-3',5'-monophosphate (cAMP), adenylate cyclase and the effect of glucose on cAMP levels in Mycobacterium spp have been reported earlier. To understand the role(s) of cAMP in these organisms, the induction of various enzyme systems was studied. Beta-galactosidase and L-tryptophanase were present at low levels of activity and could not be induced. Glycerokinase was inducible but the induction was not affected by glucose. The fructose uptake system was inducible, and the induction was lowered in the presence of glucose, but cAMP could not reverse the inhibition. cAMP binding protein was not detectable under a variety of conditions. On the basis of the lack of active cAMP binding protein, a model has been proposed to explain the apparent lack of expression of cAMP function in Mycobacterium smegmatis CDC 46.
D002352:Carrier Proteins / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism* / Q000502:physiology*; D002373:Cyclic AMP Receptor Protein; D004790:Enzyme Induction; D005632:Fructose / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D005991:Glycerol Kinase / Q000096:biosynthesis; D008954:Models, Biological; D009161:Mycobacterium / Q000378:metabolism*; D014368:Tryptophanase / Q000096:biosynthesis; D001616:beta-Galactosidase / Q000096:biosynthesis
D002352:Carrier Proteins; D002373:Cyclic AMP Receptor Protein; D005632:Fructose; D000242:Cyclic AMP; D005991:Glycerol Kinase; D001616:beta-Galactosidase; D014368:Tryptophanase; D005947:Glucose