Differential host ranges for in vitro infectivity of mouse mammary tumour viruses.
Host-range variants of mouse mammary tumour viruses (MMTVs) have previously been shown to productively infect cells of several species in vitro (Howard & Schlom, 1978). We report here that cell lines have been identified which exhibit differential restriction for replication of different MMTV variants. In addition, a cell line has been identified that changes as a function of passage in culture from being permissive to being restrictive to infection with MMTVs. MMTVs propagated in both murine and non-murine cells retained their antigenic reactivities in a group-specific radioimmunoassay for MMTVs and demonstrated no evidence for the presence of type-C viruses as determined by a variety of techniques. These studies thus establish in vitro cell substrate tropisms that can be used to differentiate between MMTVs.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002415:Cats; D002460:Cell Line; D002685:Chiroptera; D004285:Dogs; D014644:Genetic Variation; D006801:Humans; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D051379:Mice; D051381:Rats; D012190:Retroviridae / Q000276:immunology
D000956:Antigens, Viral