title: Prevention of paralysis and suppression of lymphoma in wild mice by passive immunization to congenitally transmitted murine leukemia virus.
abstract: Lake Casitas wild mice were passively immunized as newborns with antiserum to congenitally transmitted murine leukemia virus. Immunization with immunoglobulin having a high neutralizing titer to ecotropic virus and a low titer to amphotropic virus correlated with the complete prevention of paralysis and a slight (25%), but statistically insignificant, reduction in the incidence of lymphoma. Occurrence of other tumor types and total mortality rate were not affected by immunization.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000008:administration & dosage; D007116:Immunization, Passive; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000151:congenital / Q000517:prevention & control; D008223:Lymphoma / Q000151:congenital / Q000517:prevention & control*; D051379:Mice; D010243:Paralysis / Q000517:prevention & control*; D014412:Tumor Virus Infections / Q000517:prevention & control*; D014766:Viremia / Q000517:prevention & control
chemical_list: D000914:Antibodies, Viral