Simulation of the normal menstrual cycle in Kallman's syndrome by pulsatile administration of luteinizing hormone-releasing hormone (LHRH).
The administration of small doses of LHRH at 2-hourly intervals over a 27 day period to a 24-year old patient with Kallman's syndrome resulted in ovulation as indicated by: (1) a biphasic temperature response, (2) anatomical changes in the ovaries demonstrated by ultrasound, and (3) the pattern of circulating gonadotropin and gonadal steroid concentrations.
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D002582:Cervix Mucus / Q000502:physiology; D004958:Estradiol / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D008600:Menstruation-Inducing Agents / Q000008:administration & dosage; D010053:Ovary / Q000033:anatomy & histology; D010062:Ovulation Induction / Q000379:methods*; D011374:Progesterone / Q000097:blood; D013577:Syndrome
D006062:Gonadotropins; D008600:Menstruation-Inducing Agents; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol