A new model for the study of opiate B-receptors: isolated splenic strip of the cat.
Noradrenergic neurotransmission in the electrically stimulated isolated splenic strip of the cat was found to be modulated via opiate receptor. Pharmacodynamic parameters of morphine, methionine-enkephalin, azidomorphine, naloxone and N-cyclopropylmethyl-norazidomorphine (CAM) were determined. As CAM proved to be more potent than naloxone in this organ, the cat splenic strip is a useful model for the in vitro testing of opiate B-receptors.
D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008954:Models, Biological; D009019:Morphinans; D009022:Morphine Derivatives / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D009019:Morphinans; D009022:Morphine Derivatives; D011957:Receptors, Opioid; C006659:azidomorphine; D009270:Naloxone; C015097:N-cyclopropylmethylnorazidomorphine