Effect of somatomedin A and insulin on cyclic AMP generation in isolated rat hepatocytes.
Insulin and somatomedin A were shown to have inhibitory action on glucagon stimulated but not basal cyclic AMP production in isolated rat hepatocytes. The inhibition was dose-dependent and the potency per mol was about 100 fold higher for insulin than for somatomedin A.
D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis*; D005934:Glucagon / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000166:cytology*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D013002:Somatomedins / Q000494:pharmacology*
D007328:Insulin; D013002:Somatomedins; D005934:Glucagon; D000242:Cyclic AMP