Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.
Analyses of DNA and RNA from avian leukosis virus (ALV)-induced lymphomas have provided strong evidence that, in most tumours, ALV induces neoplastic disease by activating the c-myc gene, the cellular counterpart of the transforming gene of MC29 virus. The data indicate that, as a rare event, the ALV provirus integrates adjacent to the c-myc gene and that transcription, initiating from a viral promoter, causes enhanced expression of c-myc, leading to neoplastic transformation.
D001354:Avian Leukosis Virus / Q000235:genetics*; D001483:Base Sequence; D002472:Cell Transformation, Viral; D004279:DNA, Viral / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D008223:Lymphoma / Q000235:genetics*; D009876:Operon; D012334:RNA, Neoplasm / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D014158:Transcription, Genetic
D004279:DNA, Viral; D012334:RNA, Neoplasm; D012367:RNA, Viral