Immunohistological studies of nonthyroidal calcitonin-producing tumors.
A series of oat cell carcinomas of the lung and some corresponding sputum specimens were studied along with other tumors by immunoperoxidase histology for the presence of calcitonin, beta-endorphin, and ACTH. Sixteen of 31 tissues were positive for calcitonin, 12 of 14 were positive for beta-endorphin, and 11 of 14 were positive for ACTH immunoreactivity. Many tissues contained all 3 peptides, and in some sections these peptide immunoreactivities appeared to be present in the same cells. These studies suggest that there is a releationship in oat cell carcinoma of the lung and other tumors among the 3 peptides, although the basis of this relationship is not clear.
D007516:Adenoma, Islet Cell / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D002116:Calcitonin / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D003429:Cross Reactions; D004723:Endorphins / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism*
D004723:Endorphins; D000324:Adrenocorticotropic Hormone; D002116:Calcitonin