[Availability of cefotaxime. Pharmacokinetic studies on the distribution in central and various peripheral compartments (author's transl)].
After 2 g as a bolus injection the concentration of Cefotaxime was determined in serum, bone, tissue fluid, peritoneal exudate and bile under clinical conditions in 43 patients with a mean age of 61 years. Pharmacokinetic constants were calculated using a modified two compartment model. The basis for these calculations was a mean serum curve from 299 serum samples. The geometric mean and deviation factors of time-dependent values in tissue and tissue fluid are presented. The results are compared to the minimal inhibitory concentrations of pathogenic bacteria. The clinical success in 121 severe infections at a dose of 2 g every 12 hours support the theoretical results of this study.
D001202:Ascitic Fluid / Q000032:analysis; D001646:Bile / Q000032:analysis; D001682:Biological Availability; D001842:Bone and Bones / Q000032:analysis; D002439:Cefotaxime; D002511:Cephalosporins / Q000378:metabolism*; D006801:Humans; D014018:Tissue Distribution
D002511:Cephalosporins; D002439:Cefotaxime
Verfügbarkeit von Cefotaxim. Pharmakokinestische Untersuchungen über die Verteilung in zentralen und verschiedenen peripheren Kompartimenten.