An immunohistologic study of Shope fibroma virus in rabbits: tumor rejection by cellular reaction in adults and progressive systemic reticuloendothelial infection in neonates.
The development of lesions in adult and neonatal New Zealand White rabbits following intradermal inoculation of Shope fibroma virus was studied by immunofluorescence for viral antigens. T-cells, and immunoglobulin. In adults a self-limiting local fibroxanthosarcomatous tumor was rejected within 10-12 days in association with a dense infiltration of T-cells. In neonates expanding skin lesions were associated with systemic presence of virus in the reticuloendothelial system. In surviving infected neonates, granulomas formed at the site of infection after 3 weeks. These reactions may have limited further dissemination of the virus. These results support the hypothesis that the progressive disease produced by Shope fibroma virus in neonatal rabbits may be due to the inability of the reticuloendothelial system to clear infectious virus.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D012776:Fibroma Virus, Rabbit / Q000276:immunology*; D005354:Fibrosarcoma / Q000276:immunology* / Q000473:pathology; D005455:Fluorescent Antibody Technique; D007074:Immunoglobulin G / Q000276:immunology; D012157:Mononuclear Phagocyte System / Q000473:pathology*; D009365:Neoplasm Regression, Spontaneous; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology; D011212:Poxviridae / Q000276:immunology*; D011247:Pregnancy; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D007074:Immunoglobulin G