Inhibition of host DNA synthesis by adenovirus infection is reversed at elevated temperatures.
Infection of KB cells by adenovirus normally results in a drastic reduction of host DNA synthesis at 33 to 37 degrees C. This inhibition was largely reversed by raising the temperature to 41 degrees C. Inhibition was reinstated if the temperature is lowered.
D000260:Adenoviruses, Human / Q000378:metabolism*; D016590:Aphidicolin; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication / Q000187:drug effects; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000096:biosynthesis; D015247:Deoxyribonuclease HindIII; D004224:Diterpenes / Q000494:pharmacology; D006801:Humans; D009154:Mutation; D009693:Nucleic Acid Hybridization; D013696:Temperature
D004279:DNA, Viral; D004224:Diterpenes; D016590:Aphidicolin; D004247:DNA; D004262:DNA Restriction Enzymes; D015247:Deoxyribonuclease HindIII