Fluorescing cells in sputum after parenteral HpD.
Cells exfoliated into sputum were examined for fluorescence after the intravenous injection of HpD. Malignant and non-malignant cells were seen to fluoresce up to 9 days post injection of HpD. Not all exfoliated squamous cell cancer cells or non-malignant cells fluoresced. Implications are discussed relative to imaging diagnostic fluorescence bronchoscopy and photoradiation therapy of obstructing endobronchial cancers and bronchial carcinoma in situ.
D001984:Bronchial Neoplasms / Q000175:diagnosis*; D001999:Bronchoscopy / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D013183:Sputum / Q000166:cytology
D006415:Hematoporphyrins; D017324:Hematoporphyrin Derivative