title: Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature.
abstract: Two patients with plasma cell dyscrasias, manifested by osteosclerotic bone lesions and small amounts of M protein, and a complicating multi-system disorder are described. Their features of severe sensory-motor polyneuropathy, organomegaly, endocrine dysfunction, anasarca, elevated CSF protein, and skin hyperpigmentation are similar to a clinical syndrome reported primarily in Japanese men. Two previously unrecognized findings--hyperprolactinemia and an unusual radiographic abnormality of fluffy, spiculated bony proliferation--may facilitate recognition of the syndrome. The relationship of these various manifestations to the plasma cell dyscrasia is unknown, but a number of possibilities are discussed.
mesh_terms: D000328:Adult; D004700:Endocrine System Diseases / Q000150:complications*; D005260:Female; D006529:Hepatomegaly / Q000150:complications; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D009194:Myeloma Proteins; D010026:Osteosclerosis / Q000150:complications; D010265:Paraproteinemias / Q000150:complications*; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D012871:Skin Diseases / Q000150:complications*; D013163:Splenomegaly / Q000150:complications; D013577:Syndrome; D009626:Terminology as Topic
chemical_list: D009194:Myeloma Proteins