title: Antibiotic susceptibility testing of Bordetella pertussis.
abstract: A tube dilution test to evaluate the effectiveness of antibiotics against Bordetella pertussis is described. Five B. pertussis strains, including a well-characterized research strain and four fresh clinical isolates, were tested with several antibiotics. Erythromycin showed the highest in-vitro activity of the antibiotics tested. A concentration of 0.12 microgram/ml was bacteriostatic for all strains, while 2 microgram/ml was bactericidal. Minimal inhibitory and minimal bactericidal concentrations for ampicillin by tube tests were found to be higher than values previously reported for agar plate tests.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000187:drug effects*; D002701:Chloramphenicol / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D004917:Erythromycin; D002701:Chloramphenicol; D013752:Tetracycline; D012293:Rifampin; D013307:Streptomycin