T cell clones and hybridomas as probes for the analysis of the syngeneic mixed leukocyte reaction.
We have prepared short term T cell lines, long term T cell lines from soft agar colonies, and SMLR specific T cell hybridomas. Analysis of these populations has shown that the SMLR responsive T cell population is not specific for a foreign serum component, but rather represents a T cell population which can be polyclonally activated by self-Ia antigens. It is likely that some antigen specific cells are found within this autoreactive subpopulation.
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D006168:Guinea Pigs; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006825:Hybridomas / Q000276:immunology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D001324:Autoantigens; D000949:Histocompatibility Antigens Class II; D011948:Receptors, Antigen, T-Cell