title: Fat induced hypertension in rabbits. Effects of dietary fibre on blood pressure and blood lipid concentration.
abstract: Rabbits were fed diets containing 200 g.kg-1 coconut oil, palm oil, or safflower oil. Some of the diets also contained 200 g.kg-1 cellulose. The blood pressure was measured daily by a non-invasive technique for the 2 month duration of the experiment. Blood samples were drawn after an overnight fast at intervals during the experiment and analysed for lipids. Blood pressure was always increased by a fat-enriched diet. This effect was diminished and delayed by adding cellulose to the diets, though cellulose itself had no effect on the blood pressure in the absence of fat. There was a modest negative correlation between fasting serum triglyceride concentration and the blood pressure in animals fed fat enriched diets without added cellulose, but not in animals fed diets containing both fat and cellulose. These results coupled with those of Wright, Burstyn and Gibney may serve partly to explain the observation that vegetarians have lower blood pressures than omnivores, the latter consuming diets which are relatively richer in fats and poorer in fibre than the former.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002482:Cellulose / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000009:adverse effects / Q000494:pharmacology*; D004043:Dietary Fiber / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced; D011817:Rabbits / Q000502:physiology*; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber; D014280:Triglycerides; D002482:Cellulose; D002784:Cholesterol