[Investigations on combined injuries, 29th communication. Protective effect of aminopropylamino-ethylthiophosphate (WR 2721) in mice with radiation and combined injuries (irradiation and skin wound or burn) (author's transl)].
Because of the crucial practical importance of combined injuries, investigations of the efficacy of the radioprotective agent aminopropylamino-ethylthiophosphate (WR 2721) were performed on mice which were whole-body X-irradiated and stressed with a second trauma either as an open wound or as burn wounds on the skin. In cases of sole whole-body irradiation, probit analyses of our data yielded the dose reduction factors (DRF) of 2.42 (NMRI-Hannover) and 2.12 (NMRI-Kisslegg). In case of a combination of an open skin wound (SW) with irradiation in mice of the Hannover breed the following dose reduction factors have been obtained: for irradiation+SDW 10 min p. r. the DRF 2.22, for irradiation+SW 2 d p. r. the DRF 2.30, and for irradiation+SW 8 d p. R.. the DRF 2.29. In cases of combined injuries with two burn wounds (BW) as second trauma in mice of the Kissblegg breed yielded: the DRF 2.01 for irradiation+BW 10 min p. r., and the DRF 1.91 for irradiation+BW 2 d p. r. The protective effect of WR 2721 is apparently similar in the various groups with combined injuries as compared to the animals exposed to whole-body irradiation only. The mechanisms of action of the sulphur-containing radioprotective agents are discussed.
D004999:Amifostine / Q000627:therapeutic use*; D000818:Animals; D002056:Burns / Q000188:drug therapy; D005260:Female; D008433:Mathematics; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000188:drug therapy*; D014947:Wounds and Injuries / Q000188:drug therapy*
D009946:Organothiophosphorus Compounds; D004999:Amifostine
Untersuchungen über Kombinationsschäden, 29. Mitteilung. Schutzeffekt von Aminopropylamino-äthylthiophosphat (WR 2721) bei strahlen- und kombinationsgeschädigten Mädigten Mäusen (Bestrahlung plus Hautwunde bzw. Verbrennung).