title: [Histochemical-morphometric studies of skeletal muscles in advanced arterial circulation disorders of the extremities].
abstract: Biopsies of M. gastrocnemius and Nervus suralis of 12 patients with advanced disturbances of circulation were examined by means of morphometrical and histochemical methods. The histological picture of a neurogenic atrophy of the muscle fibres with partially strong hypertrophy of the slow-twitch fibres was found. The main reaction patterns and the pathogenetic mechanisms are discussed. Alterations in the ratio of type I and type II fibres are described. Fiber type disproportions, i.e. more than 75% type I fibres, may suggest that in hypoxia the type II fibres are more intensely damaged than type I fibres. There are correlations between pathological fibre distribution and the success of vasosurgical treatment.
mesh_terms: D000251:Adenosine Triphosphatases / Q000032:analysis; D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000473:pathology*; D001706:Biopsy; D003925:Diabetic Angiopathies / Q000473:pathology*; D005121:Extremities; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000166:cytology / Q000201:enzymology / Q000473:pathology*
chemical_list: D000251:Adenosine Triphosphatases
vernacular_title: Histochemisch-morphometrische Untersuchungen der Skelettmuskulatur bei fortgeschrittenen arteriellen Durchblutungsstörungen der Extremitäten.