Electron microscopic studies of herpes simplex virus type 1 infection of macrophages, T- and B-lymphocytes of mice.
The course of infection with herpes simplex virus type 1 (HSV-1) in peritoneal macrophages, phytohemagglutinin (PHA-)stimulated (T-)lymphocytes and lipopolysaccharide (LPS-)stimulated (B-)lymphocytes of NMRI-mice was studied by means of electron microscopy. Non-stimulated as well as thioglycolate-stimulated macrophages were investigated; lymphocytes were derived both from HSV-1-sensitized and non-sensitized animals. The morphological characteristics of the abortive infection in macrophages and T-lymphocytes and of the productive infection in B-lymphocytes are described. No differences were observed between stimulated and non-stimulated cells or cells of sensitized and non-sensitized animals.
D000327:Adsorption; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D001402:B-Lymphocytes / Q000382:microbiology* / Q000648:ultrastructure; D008264:Macrophages / Q000382:microbiology* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D010587:Phagocytosis; D018139:Simplexvirus / Q000254:growth & development*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000382:microbiology* / Q000648:ultrastructure; D014779:Virus Replication