Stabilization of 99mTc-pyrophosphate injection with gentisic acid.
The in vitro oxidation of 99mTc-labelled bone-scanning agents with the release of free sodium 99mTc-pertechnetate results in poor skeletal images. Gentisic acid (2,5-dihydroxy-benzoic acid), which has been used as an antioxidant to stabilize HEDP and HMDP kits, has now been shown to be an effective stabilizer for 99mTc-Pyrophosphate Injection and doses not compete for 99mTc-label.
D000818:Animals; D000975:Antioxidants; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D011756:Diphosphates; D004355:Drug Stability; D005841:Gentisates; D062385:Hydroxybenzoates; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate
D000975:Antioxidants; D011756:Diphosphates; D005841:Gentisates; D062385:Hydroxybenzoates; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium; C010925:2,5-dihydroxybenzoic acid