Experimental studies of acute and recurrent herpes simplex virus infections in the murine heart and dorsal root ganglia.
The multiplication of HSV-1 and HSV-2 strains in the heart and the corresponding dorsal root ganglia (DRG) was examined in experimentally infected mice. Infectious HSV-1 was recovered from the heart between the second and fourth day after inoculation and 3 days later from the DRG. Both the heart and DRG yielded infectious HSV-2 from the fourth to the twenty-first day after inoculation. The HSV-2, but not the HSV-1, induced recrudescent disease in chronically infected mice up to 18 months after inoculation. These affected mice showed signs of disease similar to those observed during the acute phase of the primary infection. During the recrudescent disease, infectious HSV-2 was recovered both from the heart and DRG. The possibility of using this experimental model for investigating long-term human cardiopathies is discussed.
D000818:Animals; D005727:Ganglia, Spinal / Q000382:microbiology* / Q000648:ultrastructure; D006321:Heart / Q000382:microbiology*; D006561:Herpes Simplex / Q000382:microbiology*; D051379:Mice; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure; D009500:Neutralization Tests; D012008:Recurrence; D018139:Simplexvirus / Q000302:isolation & purification*; D013997:Time Factors