Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres.
The carcinogenicity of untreated UICC chrysotile A, of acid (oxalic and hydrochloric)-leached UICC chrysotile A, of crocidolite and of JM 104 glass fibres has been studied by intrapleural injection into rats. This experiment, carried out on 304 animals, demonstrated that when more than 80% of the Mg had been leached from chrysotile fibres by either hydrochloric or oxalic acid, the proportion of pleural mesotheliomas was either nil or dramatically lower than that obtained with untreated chrysotile. The carcinogenic effect of crocidolite was higher than that of 43.7% oxalic acid-leached chrysotile. The proportion of mesotheliomas observed in animals injected with JM 104 glass fibres was similar to that in animals injected with fibres from which 63.8% had been leached with oxalic acid. These results indicate that with regard to the induction of pleural carcinogenicity by chrysotile fibres, not only size characteristics but also parameters such as chemical composition and physiochemical properties must intervene.
D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D017632:Asbestos, Serpentine; D055598:Chemical Phenomena; D002621:Chemistry; D007700:Kinetics; D008297:Male; D008654:Mesothelioma / Q000209:etiology*; D008903:Minerals / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000209:etiology; D010316:Particle Size; D051381:Rats
D017632:Asbestos, Serpentine; D008903:Minerals; D001194:Asbestos