Cardiovascular effects of iohexol in the rat and the isolated rabbit heart.
The haemodynamic and cardiac side effects of the new non-ionic contrast medium, iohexol, were investigated anaesthetized rats and isolated perfused rabbit hearts. Iohexol, caused a positive inotropic response in both models, elevated coronary flow and in high doses had an inhibitory influence on the cardiac conducting system. From a comparison with Amipaque and Urografin 76 it was concluded that with respect to cardiac side effects iohexol can be ranked between these media.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000187:drug effects*; D007463:Iodobenzoates / Q000494:pharmacology*; D007472:Iohexol; D008297:Male; D008793:Metrizamide / Q000494:pharmacology; D010477:Perfusion; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014283:Triiodobenzoic Acids / Q000494:pharmacology*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003974:Diatrizoate Meglumine; D007472:Iohexol; D008793:Metrizamide