Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus.
The purified p21src protein of Harvey sarcoma virus shows a guanine nucleotide-binding activity and, in addition, at elevated temperature an autophosphorylating activity at a threonine residue using as phosphoryl donor GTP or dGTP but not ATP or dATP. These biochemical activities are unique among those associated with transforming proteins of RNA-containing or DNA-containing tumour viruses.
D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006150:Guanine Nucleotides / Q000378:metabolism*; D051379:Mice; D015689:Oncogene Protein p21(ras); D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D009053:Sarcoma Viruses, Murine / Q000378:metabolism*; D012513:Sarcoma, Experimental / Q000378:metabolism; D013379:Substrate Specificity; D013912:Threonine / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*
D006150:Guanine Nucleotides; D010750:Phosphoproteins; D014764:Viral Proteins; D013912:Threonine; D011494:Protein Kinases; D015689:Oncogene Protein p21(ras)