[Rosette-forming ability of virus-treated human leukocytes (V-rosettes)].
Rosette-formation with auto- and allogeneic red blood cells was applied to detection of human leucocyte subpopulations interacting with Sendai virus (V-rosettes). It was shown that the majority of V-rosette-forming cells appeared to be monocytes. T lymphocytes did not take part in V-rosette-formation since selective elimination of T cells from the mononuclear cells population did not lead to reduction of but increased the number of V-rosettes. Enrichment of cell suspension with B lymphocytes was followed by a rise in the number of V-rosettes thereby allowing the attribution of B lymphocytes along with monocytes to the cell population interacting with virus. The results suggest that ability of virus-exposed immunocompetent cells to react with their own red blood cells may lie at the basis of the development of autoimmune hemolytic anemia and other autoimmune diseases.
D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000276:immunology* / Q000382:microbiology; D009000:Monocytes / Q000276:immunology; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens
Sposobnost' k rozetkoobrazovaniiu u leĭkotsitov cheloveka, obrabotannykh virusom (V-rozetki).