Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: tissue distribution in vivo and possible participation in specific cell-cell interaction.
We have described previously the detection and tissue distribution of free cell surface receptors for ecotropic R-MuLV envelope glycoprotein and the growth factor EGF in vivo [1]. More recently, we have reported the chromosomal map position of the ecotropic viral receptor and its conservation between subspecies of the genus Mus [2]. This work has shown, for the first time, the presence of multiple, independently segregating cell surface receptor genes specific for different classes of ecotropic type C viral envelope glycoprotein. In this report we extend these findings and identify chromosome 2 as coding for the receptor used by M813, an ecotropic MuLV from a feral Asian mouse. This new receptor is probably also used by oncogenic, recombinant (MCF class) MuLV of C3H origin.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D006023:Glycoproteins / Q000378:metabolism*; D006822:Hybrid Cells / Q000378:metabolism; D051379:Mice; D010455:Peptides / Q000378:metabolism*; D011863:Radioimmunoassay; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D012190:Retroviridae / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*; D014779:Virus Replication
D006023:Glycoproteins; D010455:Peptides; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; D014764:Viral Proteins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors