Glucose suppresses basal firing and haloperidol-induced increases in the firing rate of central dopaminergic neurons.
In the rat, doses of glucose sufficient to raise glucose concentrations in the blood to levels equivalent to those produced by a meal or stress suppress the firing of dopamine-containing neurons located within the substantia nigra. Glucose also prevents or reverses the increase in discharge rates of dopaminergic cells normally elicited by the antipsychotic agent haloperidol.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D005632:Fructose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology*; D006220:Haloperidol / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects*
D005632:Fructose; D005947:Glucose; D006220:Haloperidol; D004298:Dopamine