[Behavior of cAMP-deficient mutants of Salmonella typhimurium in macrophage cultures].
The behavior of c-AMP-deficient S. typhimurium mutants in the culture of peritoneal macrophages of white mice and the antibacterial activity of immune macrophages obtained from mice previously immunized with c-AMP-deficient S. typhimurium mutants were studied; c-AMP-deficient mutants were shown to have a lesser cytotoxic effect on macrophages than the initial virulent strain, while retaining their capacity for intracellular proliferation. Immune macrophages acquired the ability to withstand the cytotoxic action of the virulent strain.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D000242:Cyclic AMP / Q000172:deficiency*; D066298:In Vitro Techniques; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009154:Mutation; D010587:Phagocytosis; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
D000242:Cyclic AMP
Povedenie tsAMF-defitsitnykh mutantov Salmonella typhimurium v kul'ture makrofagov.