Sensitivity of cells in exponential and stationary growth phase to combined treatment with radiation and quinacrine.
The effect of Quinacrine on the recovery of cells from sublethal radiation injury was analysed by testing cellular survival after exposure to low and high radiation doses, and after irradiation with split doses. Quinacrine was found to inhibit recovery in cell cultures in exponential growth phase but not, or only slightly, in cells in stationary growth. This finding is related to the inhibitory effect of Quinacrine on the repair of radiation induced DNA strand breaks.
D000818:Animals; D002455:Cell Division / Q000187:drug effects* / Q000528:radiation effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D011796:Quinacrine / Q000494:pharmacology*; D011829:Radiation Dosage; D011838:Radiation-Sensitizing Agents
D011838:Radiation-Sensitizing Agents; D011796:Quinacrine