[Induction of thymidine kinase synthesis by 5-androstene-3 beta,17 beta-diol in the uterus of the immature rat].
In uteri from immature female rats, thymidine kinase activity was largely increased by administration of 5-androstene-3 beta, 17 beta-diol. Kinetic studies showed that the enzyme activity reached its maximum level 30 h after hormone administration. That increase in thymidine kinase activity was dose-dependent and could be related to the synthesis of new molecules of enzyme. Moreover, it was exclusively observed in target-organs for estrogens. It was concluded that 5-androstene-3 beta, 17 beta-diol which results from the metabolism of dehydroepiandrosterone had estrogen-like properties with regard to the induction of thymidine kinase.
D015114:Androstenediol / Q000494:pharmacology*; D000734:Androstenediols / Q000494:pharmacology*; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D051381:Rats; D013937:Thymidine Kinase / Q000096:biosynthesis*; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
D000734:Androstenediols; D015114:Androstenediol; D013937:Thymidine Kinase
Induction de la synthèse de la thymidine kinase par le 5-androstène-3 beta, 17 beta-diol dans l'utérus de la ratte immature.