[A molecular abnormality of the erythrocyte membrane in beta-thalassemia].
We present a new abnormality of the red cell membrane observed in the course of a study on beta-thalassemia. In a child suffering from a beta 0-thalassemia major, the neutral membrane bound phosphatase, instead of having Michaelis-Menten kinetics, displayed a biphasic kinetics consistent with inhibition by substrate excess. This abnormality is discussed along with other erythrocyte membrane alterations that are known to occur in beta-thalassemia.
D002648:Child; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D010744:Phosphoric Monoester Hydrolases / Q000097:blood*; D013789:Thalassemia / Q000201:enzymology*
D010744:Phosphoric Monoester Hydrolases
Une anomalie moléculaire de la membrane érythrocytaire au cours des beta-thalassémies.