title: The antigonadotropic activity of Lithospermum ruderale I. The lack of steroid-like activity at the receptor level.
abstract: Previous work has demonstrated that extracts from the plant Lithospermum ruderale have antigonadotropic activity. The possibility of steroidal substances being responsible for this activity was examined at the receptor level. It was found that only at very high concentrations of crude lithosperm extract (LS) was progesterone, testosterone, or estradiol displaced from their respective uterine receptors. Because such high doses of LS may be toxic and because they are not required for in vivo or in vitro bioactivity, it is concluded that the antigonadotropic components of Lithospermum ruderale probably do not as a steroid.
mesh_terms: D004958:Estradiol / Q000502:physiology; D006062:Gonadotropins / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011956:Receptors, Cell Surface / Q000502:physiology; D011960:Receptors, Estrogen / Q000502:physiology; D011980:Receptors, Progesterone / Q000502:physiology; D013739:Testosterone / Q000502:physiology
chemical_list: D006062:Gonadotropins; D010936:Plant Extracts; D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D013739:Testosterone; D004958:Estradiol