Review: effect of anti-ulcer drugs on gastric mucous barrier and possible cyclic AMP involvement.
Since cimetidine in spite of its ulcer-healing properties was found to have a damaging effect on gastric mucus, the problem of the influence of anti-ulcer drugs on mucous barrier became of topical interest. The effects of various anti-ulcer drugs on gastric mucus secretion are briefly reviewed and the possible role of changes in cyclic AMP levels of gastric mucosa is discussed.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002229:Carbenoxolone / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005778:Gefarnate / Q000494:pharmacology; D006801:Humans; D009093:Mucus / Q000378:metabolism; D010276:Parasympatholytics / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D010276:Parasympatholytics; D011453:Prostaglandins; D005778:Gefarnate; D002927:Cimetidine; D000242:Cyclic AMP; D010418:Pentagastrin; D002229:Carbenoxolone