[Enzymatic and immunologic study of the role of the thyroid hormone in the formation of the internal mitochondrial membrane during postnatal development of the rat].
Hypothyroidism induces an increase of liver D-beta-hydroxybutyrate dehydrogenase activity. Injection of thyroid hormone reverses the phenomena. The use of monospecific antibody raised against the purified enzyme indicates that there was not an increase of apoenzyme biosynthesis. The thyroid hormone negative control is due to a metabolism alteration of the membrane phospholipids which are directly involved in the apoenzyme activity. The highest difference is observed with 20 days old rats. Opposite effects were obtained on succinate cytochrome c reductase.
D000818:Animals; D006884:Hydroxybutyrate Dehydrogenase / Q000096:biosynthesis / Q000378:metabolism*; D007037:Hypothyroidism / Q000201:enzymology* / Q000276:immunology; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology / Q000502:physiology*; D014284:Triiodothyronine / Q000494:pharmacology / Q000502:physiology*
D014284:Triiodothyronine; D006884:Hydroxybutyrate Dehydrogenase; D013974:Thyroxine
Etude enzymatique et immunologique du rôle de l'hormone thyroïdienne sur la genèse de la membrane interne mitochondriale au cours du développement post-natal chez le rat.