title: [Neuropharmacology of cultured cells: studies on receptors, synapses and neuronal function of clonal cells (author's transl)].
abstract: This review concerns neuropharmacological properties of clonal cells from tumors in the nervous system and muscle, and/or somatic hybrid cells derived from these clonal preparations. These cells grow well under conditions of culture and show neuronal characteristics identical to those seen in normal cells. Observations of these clonal cells contribute to studies on development, differentiation, synaptogenesis and cellular recognition in the nervous system. Analysis of eukaryotic genes also enables investigations on genetic control mechanisms by which highly differentiated neuronal functions are expressed.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured / Q000502:physiology*; D002999:Clone Cells / Q000378:metabolism / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004361:Drug Tolerance; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology*; D008564:Membrane Potentials; D051379:Mice; D009423:Nervous System Neoplasms / Q000473:pathology; D009447:Neuroblastoma; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D019966:Substance-Related Disorders; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D011942:Receptors, Adrenergic, alpha; D011957:Receptors, Opioid; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006152:Cyclic GMP