The effect on paracetamol absorption of stimulation and blockade of beta-adrenoceptors.
1 The effect of drugs acting on beta-adrenoceptors on the absorption and excretion of paracetamol was studied in 26 volunteers and nine patients with mild hypertension, each subject acting as his/her own control. 2 Isoprenaline given 30 min before paracetamol significantly slowed absorption, the effect being dose related, and blocked by prior administration of propranolol. 3 When isoprenaline was given immediately before the paracetamol, absorption was not altered, although a cardiovascular response was seen. 4 Oral salbutamol also delayed paracetamol absorption. 5 Propranolol given alone increased the rate of paracetamol absorption. 6 These results with the changes in the rate of gastric emptying produced by these agents.
D000082:Acetaminophen / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000420:Albuterol / Q000494:pharmacology; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D007408:Intestinal Absorption; D007545:Isoproterenol / Q000494:pharmacology; D008875:Middle Aged; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D000082:Acetaminophen; D011433:Propranolol; D007545:Isoproterenol; D000420:Albuterol