[Rapid induction of liver cirrhosis in rats by treatment with ethanol, carbon tetrachloride and progesterone].
The administration of progesterone increases the degree of liver cirrhosis in rats treated with CCl4 and ethanol. Pseudolobulation with large amount of interstitial fibrosis are obtained after only 6 weeks of treatment. The ability of progesterone to suppress collagenase activity is supposed to be responsible of the strong increase of cirrhosis.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008104:Liver Cirrhosis, Alcoholic / Q000139:chemically induced* / Q000201:enzymology; D008297:Male; D003012:Microbial Collagenase / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D012737:Sex Factors
D011374:Progesterone; D003012:Microbial Collagenase
Induzione rapida di una cirrosi epatica nel ratto mediante associazione di etanolo, tetracloruro di carbonio e progesterone.