Neutrophil dysfunction associated with states of chronic and recurrent infection.
Infants, children, and young adults who suffer chronic and recurrent bacterial or fungal infection despite adequate numbers of circulating granulocytes and normal or elevated levels of immunoglobulins should be suspected of having fundamental defects in granulocyte functioning. This article considers clinical disorders for which there is evidence for associated defects of polymorphonuclear leukocytes.
D000293:Adolescent; D000818:Animals; D002448:Cell Adhesion; D002609:Chediak-Higashi Syndrome / Q000503:physiopathology; D002630:Chemotactic Factors / Q000037:antagonists & inhibitors / Q000502:physiology; D002634:Chemotaxis, Leukocyte; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000378:metabolism; D006105:Granulomatous Disease, Chronic / Q000503:physiopathology; D006402:Hematologic Diseases / Q000503:physiopathology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D007057:Ichthyosis / Q000276:immunology; D007073:Immunoglobulin E; D007231:Infant, Newborn; D007239:Infections / Q000503:physiopathology*; D008206:Lymphatic Diseases / Q000503:physiopathology; D008297:Male; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption; D009195:Peroxidase / Q000172:deficiency; D010585:Phagocyte Bactericidal Dysfunction / Q000503:physiopathology; D011817:Rabbits; D013203:Staphylococcal Infections / Q000276:immunology
D002630:Chemotactic Factors; D007073:Immunoglobulin E; D010088:Oxidoreductases; D009195:Peroxidase