[Blocking action of nickel, cobalt, manganese, and magnesium ions on the inward current through the potassium channel of Limnea stagnalis pond snail neurons].
The dose-inward current relationship for calcium channel blocking ions of Ni, Co, Mn and Mg was studied by means of intracellular dialysis and voltage clamp in isolated neurons from the mollusc Limnea stagnalis. For all the four ions the effect was described by the Langmuir isotherm with KMn = 0.36 +/- 0.05 m,, KNi = KCo = 0.74 +/- 0.07 mM, KMg = 18.2 +/- 5.00 mM. These bivalent cations compete with current-carrying ions for a common binding site in the channel's entrance.
D000818:Animals; D003035:Cobalt / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007473:Ion Channels / Q000187:drug effects*; D008195:Lymnaea; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D009532:Nickel / Q000494:pharmacology; D014131:Trace Elements / Q000494:pharmacology*
D007473:Ion Channels; D014131:Trace Elements; D003035:Cobalt; D008345:Manganese; D009532:Nickel; D008274:Magnesium
Blokiruiushchee deĭstvie ionov nikelia, kobal'ta, margantsa i magniia na velichinu vkhodiashchego toka cherez kal'tsievyĭ kanal neĭronov prudovika Limnea stagnalis.