title: Different sensitivities of rat cells to infection by ecotropic murine leukemia viruses.
abstract: The titration curves of ecotropic murine leukemia viruses with various rat cells were determined by the reverse XC assay method. The curves of N-, B-, and NB-tropic viruses with Hepano cells (derived from a Sprague-Dawley rat) and Sprague-Dawley embryo cells were of single-hit type. In contrast, the curves of these viruses with 3Y1 cells (derived from a Fischer rat) and Fischer rat embryo cells were of two-hit type. Thus, the cells derived from the Sprague-Dawley rat were sensitive to infection by ecotropic murine leukemia viruses but the cells derived from the Fischer rat were resistant.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007109:Immunity; D009052:Leukemia Virus, Murine / Q000254:growth & development*; D007942:Leukemia, Experimental / Q000276:immunology*; D051381:Rats; D013045:Species Specificity