Anti-Rh41, a new Rh antibody found in association with an abnormal expression of chromosome 1 genetic markers.
A new antibody, anti-Rh41, is described. This antibody was found prepartum in a multiparous, Caucasian female with no prior history of transfusions. Anti-Rh41 reacts with red blood cells from individuals with cis oriented C and e genes, but is nonreactive with cells possessing the products derived from individuals with cis-oriented Cw and e genes, a characteristic which distinguishes this antibody from anti-rhi. Furthermore, in contrast to anti-rhi, anti-Rh41 consistently reacts with Negro rh's (VS-positive) bloods. Also noteworthy in this study is the presence of an abnormal expression of chromosome 1 genetic markers in an offspring of the propositus.
D000042:Absorption; D000328:Adult; D000918:Antibody Specificity; D002900:Chromosomes, Human, 1-3; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics; D009703:Nucleoside-Phosphate Kinase / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics; D012204:Rh-Hr Blood-Group System / Q000235:genetics*
D007518:Isoantibodies; D007527:Isoenzymes; D012204:Rh-Hr Blood-Group System; C023276:uridine monophosphate kinase; D009703:Nucleoside-Phosphate Kinase; D010733:Phosphoglucomutase