Variations of cAMP in epidermis and plasma of male adult subjects.
Over a time span of 66 h (sampling time at every 6th hour) the cAMP content in superficial skin punch biopsies of 8 male volunteers (medical students aged 20-30 years) and simultaneously the cAMP level in plasma were measured. By means of autocorrelation (2 alpha less than or equal to 5%) a circadian rhythm in the epidermal cAMP could be demonstrated. Sharp maxima were detected at midnight, whereas minima (not so clearly expressed) were seen at 6 a.m. A variation in plasma cAMP during the day was also established but no significant hint for a circadian rhythm could be found by autocorrelation.
D000328:Adult; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000097:blood*; D004817:Epidermis / Q000378:metabolism*; D006801:Humans; D008297:Male
D000242:Cyclic AMP