Growth hormone stimulates drug-induced porphyrin formation in liver cells maintained in a serum-free medium.
Human growth hormone and a few other related polypeptide hormones enhanced porphyrin formation induced by 2-allyl-2-isopropylacetamide in chick embryo liver cells maintained in a serum-free medium. The stimulatory effect of human growth hormone on drug-induced porphyrin formation was significant at 10 ng/ml and increased in a dose-dependent manner. Human growth hormone did not stimulate porphyrin formation in otherwise untreated cultures. These findings thus demonstrate a potentiating effect of growth hormones on hepatic porphyrin formation.
D015124:8-Bromo Cyclic Adenosine Monophosphate; D000502:Allylisopropylacetamide / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002478:Cells, Cultured; D002642:Chick Embryo; D003470:Culture Media; D000242:Cyclic AMP / Q000031:analogs & derivatives / Q000494:pharmacology; D013006:Growth Hormone / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011166:Porphyrins / Q000096:biosynthesis*; D014284:Triiodothyronine / Q000494:pharmacology
D003470:Culture Media; D007328:Insulin; D011166:Porphyrins; D014284:Triiodothyronine; D015124:8-Bromo Cyclic Adenosine Monophosphate; D000502:Allylisopropylacetamide; D003994:Bucladesine; D013006:Growth Hormone; D000242:Cyclic AMP; D006854:Hydrocortisone