[Role of erythrocyte membrane lipids in the antagonism between vitamin A and D3].
The "in vitro" lytic effect of retinol (35 microM) on various animal species erythrocytes is partially inhibited by cholecalcipherol. The inhibition observed is not related with reduction of retinol bound by erythrocytes membranes while it can be related with the amount of glycolipids not gangliosides of these cells. Instead, we have observed that the amount of retinol molecules bound to erythrocytes membranes and their haemolysis can be related with the gangliosides contents of red cells membranes.
D000818:Animals; D002762:Cholecalciferol / Q000494:pharmacology*; D004336:Drug Antagonism; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D008563:Membrane Lipids / Q000097:blood*; D014801:Vitamin A / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D008563:Membrane Lipids; D014801:Vitamin A; D002762:Cholecalciferol
Ruolo dei lipidi eritrocitari nell'antagonismo tra le vitamine A e D3.