title: The effect of Escherichia coli endotoxins on the concentrations of corticosterone and growth hormone in the plasma of the domestic fowl.
abstract: The intravenous injection of chickens aged six to 11 weeks with Escherichia coli endotoxins (serogroups O111 and O78) produced a large increase in the plasma corticosterone concentration which was maximal (five to 10-fold) after 1 h and still evident after 8 h. It did not vary with the dose over the range 0.1 to 2 mg/kg and was smaller than that produced by adrenocorticotrophic hormone (ACTH) (20 iu/kg). A decrease in growth hormone concentration was detected between 1 and 2 h after endotoxin administration in six- to seven-week-old birds, this change being opposite to that which occurs in man.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002645:Chickens / Q000097:blood*; D003345:Corticosterone / Q000097:blood*; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D004926:Escherichia coli; D013006:Growth Hormone / Q000097:blood*; D007275:Injections, Intravenous; D008297:Male
chemical_list: D004731:Endotoxins; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D003345:Corticosterone