[Polyneuritis after use of perhexiline maleate: quantimetric and ultrastructural study (author's transl)].
The authors record a new case of polynevritis through a prolonged use of perhexiline maleate. The acute neurological episode occurred 14 months after the beginning of the treatment when the daily doses had been raised to 600 mg for 2 months. The biopsy of the peripheral nerve was carried out only 27 months later as the posology was brought down to 200 mg and the clinical symptomatology had almost completely diminished. This probably accounts for the unusual aspects observed on semi-thin and ultrathin sections: a very remarkable reduction of the number of myelinated fibers and the severity of the phenomena of Wallerian degeneration, contrasting with the rarity of intra-cytoplasmic multilamellar schwannian inclusions, classically observed in the course of polynevritis caused by perhexiline maleate. The direct toxic action of the drug upon the neuron has been discussed.
D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009474:Neurons / Q000187:drug effects; D010480:Perhexiline / Q000008:administration & dosage / Q000009:adverse effects*; D010525:Peripheral Nerves / Q000648:ultrastructure*; D010880:Piperidines / Q000009:adverse effects*; D011129:Polyradiculoneuropathy / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D014855:Wallerian Degeneration
D010880:Piperidines; D010480:Perhexiline
Polyradiculonévrite au maléate de perhexiline: étude quantimétrique et ultrastructurale.