title: Virus exposure diminishes beta-adrenergic response in human leukocytes.
abstract: We used Ficoll-Hypaque isolated peripheral lymphocytes and PMNs to investigate the relationship between viral exposure and beta-adrenergic responses in target cells. Lymphocyte E-rosette formation with sheep red blood cells and PMN beta-glucuronidase release in response to opsonized zymosan particles are two cell activities regulated by beta-adrenergic agonists. After incubation with influenza or measles virus, the treated cells have decreased response to isoproterenol, a beta-adrenergic agonist. The in vitro viral exposure causes a decreased beta-adrenergic response in target cells.
mesh_terms: D000328:Adult; D005966:Glucuronidase / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D009980:Influenza A virus; D007962:Leukocytes / Q000502:physiology*; D008459:Measles virus; D009504:Neutrophils / Q000502:physiology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012397:Rosette Formation; D014777:Virus Diseases / Q000503:physiopathology*
chemical_list: D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D005966:Glucuronidase