Technetium-99m pyrophosphate uptake in experimental viral perimyocarditis. Sequential study of myocardial uptake and pathologic correlates.
The myocardial uptake of technetium-99m pyrophosphate (99mTc-PYP) in perimyocarditis induced by coxsackievirus B3 in BALB/c mice was studied. 99mTc-PYP uptake ratio, measured by the ratio of counts/min per gram for the heart to counts/min per gram for the skull, began to increase 5 days after virus inoculation when myocardial necrosis was evident. On the seventh day after the inoculation, 99mTc-PYP ratio reached a maximum. Histologically, fine, dystrophic calcification appeared in the necrotic fibers. 99mTc-PYP uptake was in proportion to the extent of the myocardial lesions. Thereafter, cellular infiltrations increased with time and were most severe on the fourteenth day, but 99mTc-PYP ratio had begun to fade. On the twenty-eighth day, perimyocardial fibrosis increased and calcification was still present, but 99mTc-PYP ratio had decreased. Myocardial uptake with severe pathologic lesions was visualized on a whole-body image on the seventh day after inoculation with the virus. The findings may provide a basis upon which 99mTc-pyp imaging may be applied to viral perimyocarditis in humans.
D000818:Animals; D003384:Coxsackievirus Infections / Q000000981:diagnostic imaging* / Q000473:pathology; D029822:Enterovirus B, Human; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000000981:diagnostic imaging* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D010493:Pericarditis / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism
D013667:Technetium