Possible occurrence of Na+-dependent Ca2+ influx mechanism in isolated bovine chromaffin cells.
Chromaffin cells were isolated from bovine adrenals and the effects of experimental manipulations which alter the level of internal Na+ on the release of catecholamines and 45Ca uptake by these cells were investigated. In response to NA+ deprivation both parameters were increased or decreased when internal NA+ was raised or reduced, respectively. The results suggest the existence of Na+-dependent Ca2+ influx mechanism in these cells.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002838:Chromaffin System / Q000378:metabolism*; D004759:Enterochromaffin Cells / Q000187:drug effects / Q000378:metabolism*; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
D002395:Catecholamines; D007473:Ion Channels; D010042:Ouabain; D012964:Sodium; D011188:Potassium; D002118:Calcium