Reciprocal antagonism between ACTH1-24 and beta-endorphin in rats.
ACTH1-24 and beta-endorphin simultaneously injected at 5-10 microgram dose into the lateral ventricle, reciprocally suppress most of their respective behavioural effects (stretching-yawning syndrome, sexual excitement and hyperalgesia for ACTH1-24 and catalepsy and analgesia for beta-endorphin). The results obtained support the hypothesis that ACTH1-24 and beta-endorphin might interact antagonistically at CNS level.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003366:Cosyntropin / Q000494:pharmacology*; D004336:Drug Antagonism; D004723:Endorphins / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010413:Penis / Q000187:drug effects; D051381:Rats
D004723:Endorphins; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone