Marked lethality of rats in combined exposure to carbon monoxide and diethyldithiocarbamate.
Simultaneous exposure of rats to carbon monoxide (COHb 60%) and diethyldithiocarbamate (i.p. 0.5 g/kg), a superoxide dismutase inhibitor, for 2.5 h resulted in a death of sixteen out of twenty-three rats. No rats treated with saline and exposed to CO died (0/26). There were no fatalities among the group of rats injected with the diethyldithiocarbamate solution and exposed to ambient air (0/16).
D000818:Animals; D002248:Carbon Monoxide / Q000633:toxicity*; D002263:Carboxyhemoglobin / Q000378:metabolism; D004050:Ditiocarb / Q000633:toxicity*; D004357:Drug Synergism; D008297:Male; D051381:Rats; D013859:Thiocarbamates / Q000633:toxicity*
D013859:Thiocarbamates; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D004050:Ditiocarb