Iron increases collagenase production by rabbit synovial fibroblasts.
Ionic iron, as the chelate FeNTA, was taken up by rabbit synovial fibroblasts in monolayer culture. Uptake was accompanied by increased production of latent collagenase and PGE2. Concomitant addition of desferrioxamine, a specific chelator of Fe+++, prevented iron uptake and induction of collagenase and PGE2. Collagenase induced by iron may have a role in the pathogenesis of certain disease states associated with abnormal iron deposition.
D000818:Animals; D002452:Cell Count; D003035:Cobalt / Q000494:pharmacology; D003676:Deferoxamine / Q000494:pharmacology; D005290:Ferric Compounds / Q000494:pharmacology; D005347:Fibroblasts / Q000201:enzymology; D006168:Guinea Pigs; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D008345:Manganese / Q000494:pharmacology; D003012:Microbial Collagenase / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D011506:Proteins; D011817:Rabbits; D013582:Synovial Fluid / Q000166:cytology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D005290:Ferric Compounds; D011458:Prostaglandins E; D011506:Proteins; D003035:Cobalt; D008345:Manganese; D007501:Iron; D003012:Microbial Collagenase; D003676:Deferoxamine; D013755:Tetradecanoylphorbol Acetate