The lack of affinity of prostaglandins to dopaminergic and opiate receptors in the rat striatum.
The aim of this paper was to study whether prostaglandins (PGs) E1, E2 and F2 alpha affect the binding of specific ligands for dopaminergic or opiate receptors 3H-spiroperidol or 3H-naloxone in the rat striatum. The PGs, even in very high concentrations, did not change 3H-spiroperidol or 3H-naloxone binding to rat striatal membranes in vitro. This indicates that in the striatum of rats PGs do not interact directly with dopaminergic and opiate receptors.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D011957:Receptors, Opioid / Q000187:drug effects* / Q000378:metabolism
D011453:Prostaglandins; D011954:Receptors, Dopamine; D011957:Receptors, Opioid