Sympathetic nerve terminal destruction has no effect on specific [3H]ouabain binding to intact mouse and rat skeletal muscle.
Following pretreatment with 6-OH-dopamine, the sympathetic nerve endings of the iris and skeletal muscle of mice and rats were not longer detectable by cytochemistry for noradrenaline. In the same animals, the specific binding of [3H] ouabain to intact soleus muscles was not significantly different from that measured in controls, Neither ouabain-suppressible 42K uptake nor Na-K contents were affected by chemical sympathectomy.
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D006651:Histocytochemistry; D051379:Mice; D009132:Muscles / Q000294:innervation / Q000378:metabolism*; D009411:Nerve Endings / Q000378:metabolism*; D010042:Ouabain / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013563:Sympathectomy, Chemical
D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase