[Test of pituitary adrenal restraining with IV dexamethasone in the diagnosis of Cushing's syndrome (author's transl)].
The authors report a pituitary adrenal retraining test, using a 4 h IV infusion of dexamethasone phosphate (4 mg). Plasma cortisol is measured before and at the end of the infusion. The results allow a good discrimination between Cushing's disease (bilateral adrenal hyperplasia : 9 cases) and Cushing's syndrome of tumorous origin (adrenal tumors 7 cases, ectopic ACTH syndrome 3 cases, hypophyseal adrenomas 2 cases), only bilateral adrenal hyperplasia cases are lowering significantly.
D000310:Adrenal Gland Neoplasms / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000097:blood; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis*; D003907:Dexamethasone / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007263:Infusions, Parenteral; D009765:Obesity / Q000097:blood; D010911:Pituitary Neoplasms / Q000097:blood; D010912:Pituitary-Adrenal Function Tests
D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Le test de freinage cortico-surrénal par le phosphate de dexaméthasone intra-vineux.