[Induction of immunologic tolerance to transplantation antigens using conditioning of the lymphocyte genome of the recipient with ribonucleic acid from the donor].
The phenomenon of specific immunosuppression which we call "immunologic tolerance" constitutes the final result common to diverse processes partially known. The study of the phenomena inter or intra cellular involved in the divese mechanisms of production, however constitutes a field which is quite obscure. The explanation of these phenomena could offer us some fundamental knowledge towards the better understanding and subsequent manipulation of the process. This present project of investigation proposes to study the possibility of transferring one of these states of tolerance which is better established as is the spontaneous tolerance to the proper antigens of an animal (donor) to a second animal (receptor) genetic and for that reason, antigenically different, through an informational molecule such as the ribonucleo acid (RNA) extracted from the donor animal. This hypothesis is based theoretically on the following points: 1) The state of "self-immunologic tolerance" is probably an active and dynamic phenomenon, in which one can determine the presence of lymphocytes with receptors for proper antigens, without establishing in normal conditions an efferent phase of the immunologic answer, which determines an effect on this antigen. 2) The effective immunologic reactivity (allergic answer) of a determined animal is transferable to a second non-sensitized animal through RNA from the first animal. In this study we present the results of the conditioning of the allogenic reactivity of one strain of mice, through the exposition of the same to RNA extracted from one congenic-resistent strain with respect to first.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D006183:H-2 Antigens / Q000276:immunology*; D006433:Hemocyanins / Q000276:immunology; D007108:Immune Tolerance; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D007961:Leukocyte Migration-Inhibitory Factors / Q000032:analysis; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology
D006183:H-2 Antigens; D007961:Leukocyte Migration-Inhibitory Factors; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin
Inducción de tolerancia inmunológica a antígenos de trasplante, mediante condicionamiento del genoma linfocitario del receptor con ácido Ribonucleico del donante.