title: [Features of the kinetic and stationary characteristics of aconitine-modified sodium channels].
abstract: Kinetic and steady-state characteristics of aconitine-modified sodium channels were studied in the Ranvier node membrane. Aconitine-modified sodium channels are shown to be inactivated only partially. The voltage dependence of the fraction of noninactivated channels (h infinity) may be described by a three-state model of the channel with closed, open and inactivated states. A reasonable agreement with the data was obtained when parameters of the inactivated state were supposed to be not changed after aconitine modification of the channels. The membrane repolarization to -70 divided by -110 mV, after long (10 ms) depolarizing shift induces firstly fast current decay ("tail") and then its rather slow increase to a steady-state level. Kinetics of this current requires two or more open states to be postulated.
mesh_terms: D000157:Aconitine / Q000494:pharmacology*; D031841:Aconitum / Q000031:analogs & derivatives*; D000818:Animals; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D007700:Kinetics; D008564:Membrane Potentials; D011895:Rana ridibunda; D011901:Ranvier's Nodes / Q000187:drug effects* / Q000502:physiology; D012964:Sodium / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D012964:Sodium; D000157:Aconitine
vernacular_title: Nekotorye osobennosti kineticheskikh i statsionarnykh kharakteristik natrievykh kanalov, modifitsirovannykh akonitinom.