[Effect of acute administration of high doses of ethanol on the canalicular Na+K+ dependent ATPASE in the isolated and perfused rat liver].
Na+-K+-ATPase in canaliculi-enriched liver plasma membranes was found to be inhibited by high concentration of ethanol (12 mmoles %ml) both in vitro and in vivo; the decrease of Na+-K+-ATPase, which is considered a major factor in the production of bile-salt independent fraction of canalicular bile flow, may be the cause of the previously observed reduction of bile flow after ethanol administration.
D000818:Animals; D001646:Bile / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis*
D000431:Ethanol; D000254:Sodium-Potassium-Exchanging ATPase
Effetto della somministrazione acuta di alte dosi di etanolo sull'ATP-asi canalicolare Na+K+ dipendente nel fegato isolato e perfuso di ratto.