Plasmin cleaves human beta-casein.
Plasmin cleaves isolated human beta-casein to form specific fragments in a manner similar to the generation of gamma 1-, gamma 2-, and gamma 3-caseins from the bovine homologue. Identification of a protein previously isolated from human milk as a specific plasmin cleaved portion of beta-casein indicates that endogenous plasmin is active in whole milk. These findings suggest that protease activity should be considered in casein quantitation or isolation of components from human milk.
D000595:Amino Acid Sequence; D002364:Caseins / Q000378:metabolism*; D004589:Electrophoresis, Disc; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D008895:Milk, Human; D010446:Peptide Fragments / Q000032:analysis; D011247:Pregnancy
D002364:Caseins; D010446:Peptide Fragments; D005341:Fibrinolysin