Stress-induced eating is mediated through endogenous opiates.
The interaction of endogenous opiates and stress-induced eating in rats was evaluated by pharmacological manipulation. Eating induced by the tail-pinch method was inhibited by the opitate antagonist naloxone; after being repeatedly stressed over a 10-day period and then given nalozone, the rats behaved in a manner indistinguishable from the "wet-dog" shakes of opiate withdrawal. Thus endogenous opiates may have a role in the control of stress-related eating, a finding that may have therapeutic implications for humans.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002766:Cholecystokinin / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000502:physiology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D013312:Stress, Physiological / Q000503:physiopathology*
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D002766:Cholecystokinin; D003975:Diazepam