Inhibition of adjuvant arthritis by salbutamol and aminophylline.
Salbutamol (3 mg/kg) and aminophylline (75 mg/kg) were administered s.c. to rats separately or in combination after intradermal injection of adjuvant into the left hind paw. The paw volume was measured plethysmographically; tissue cyclic AMP content was determined by a protein binding assay following whole body microwave irradiation. The combination of salbutamol and aminophylline given daily significantly inhibited the swelling response in both the adjuvant-injected and the non-injected paws. This drug combination significantly increased the cyclic AMP levels in inflamed tissue of the adjuvant-injected hind paw and in lymphoid tissue such as the spleen and thymus. The combined treatment seems to have immunosuppressive as well as anti-inflammatory effects on adjuvant-induced arthritis.
D000420:Albuterol / Q000627:therapeutic use*; D000628:Aminophylline / Q000627:therapeutic use*; D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001835:Body Weight / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism; D013997:Time Factors
D000628:Aminophylline; D000242:Cyclic AMP; D000420:Albuterol