title: Renal allograft function and cytomegaly.
abstract: A retrospective study in 20 seronegative and 61 seropositive (complement fixation) first cadaver donor graft recipients brought evidence that in cytomegaly, not the infection alone, but curtailment of azathioprine shortly after transplantation (or summation of both) may result in rejection and impaired graft survival. Preliminary data (accumulation of 125I-labelled fibrinogen in two and morphology of the graft in two other patients) showed that depression of graft function in cytomegaly is not necessarily due to rejection.
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use*; D003586:Cytomegalovirus Infections / Q000209:etiology*; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D011183:Postoperative Complications; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D001379:Azathioprine