Cell-mediated immunity in experimental parainfluenza type 3 virus infection.
Local respiratory-tract infection was produced experimentally in guinea-pigs by intranasal instillation of a suspension of parainfluenza virus type 3. Histologically, interstitial pneumonitis developed within 10 days and persisted for at least 70 days. Cell-mediated immunity was measured at intervals for 70 days after infection. Dermal reactivity could not be elicited. Leucocyte-migration inhibition and macrophage-migration inhibition were increased. Macrophage aggregation was present. Increased cell-mediated immunity could be transferred from infected donor animals to normal recipient animals by adoptive spleen-cell transfer even 60 and 70 days after infection.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002449:Cell Aggregation; D002464:Cell Migration Inhibition; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology; D008168:Lung / Q000473:pathology; D008264:Macrophages / Q000276:immunology; D008297:Male; D009500:Neutralization Tests; D010224:Parainfluenza Virus 3, Human / Q000276:immunology; D018184:Paramyxoviridae Infections / Q000276:immunology* / Q000473:pathology
D000914:Antibodies, Viral