Characterization of NAD-glycohydrolase in rat lymphoid organs.
Rat thymus and thymocytes possess an NAD-glycohydrolase activity lower than spleen and spleen lymphocytes. In all cases, the highest activity (50%) is bound to the nuclei, while that in the soluble fraction is higher (in percent) in the lymphocytes than in the whole organ. Considering that thymus and thymocytes are characterized by a soluble NAD-ase activity higher than in spleen and in spleen lymphocytes, and that lymphocytes in general have a greater soluble than microsomal activity, we interpret these findings are evidence that the soluble NAD-ase is due essentially to T lymphocytes, of which it represents a typical feature.
D000818:Animals; D007700:Kinetics; D008221:Lymphoid Tissue / Q000201:enzymology*; D008297:Male; D009244:NAD+ Nucleosidase / Q000378:metabolism*; D010206:Papain; D051381:Rats; D013154:Spleen / Q000201:enzymology; D013347:Subcellular Fractions / Q000201:enzymology; D013601:T-Lymphocytes / Q000201:enzymology; D013950:Thymus Gland / Q000201:enzymology
D009244:NAD+ Nucleosidase; D010206:Papain