Effect of sodium diethyl dithiocarbamate on mitogen induced lymphoproliferation "in vitro".
Sodium diethyl dithiocarbamate (DTC) is a low molecular weight sulphur compound which has been shown to be an adjuvant of immunity in vivo. In this report, DTC was shown to inhibit in vitro DNA-synthesis of human peripheral blood lymphocytes stimulated by phytohemagglutinin or concanavalin A. DTC could act directly at the cellular level and indirectly by interfering with culture medium or lectins.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004050:Ditiocarb / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013859:Thiocarbamates / Q000494:pharmacology*
D010835:Phytohemagglutinins; D013859:Thiocarbamates; D003208:Concanavalin A; D004247:DNA; D004050:Ditiocarb