Growth-related alterations induced in chick embryo fibroblasts by src-gene deletion mutants of the Schmidt-Ruppin strain of Rous sarcoma virus.
Certain tdSRD viruses induce multilayered cell foci, agar colony formation, and increased density of cellular populations in line-15 chick embryo fibroblasts. These alterations in cellular growth properties are distinct from oncogenic transformation. Available evidence favors the idea that transformation-defective focus formation is caused by one or more of the replicative viral genes, but which of the three-gag, pol, or env-is involved, remains to be determined.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics*; D002352:Carrier Proteins / Q000378:metabolism; D002455:Cell Division; D002472:Cell Transformation, Viral; D002642:Chick Embryo; D002872:Chromosome Deletion; D003599:Cytoskeleton / Q000648:ultrastructure; D003673:Defective Viruses / Q000235:genetics; D005353:Fibronectins / Q000378:metabolism; D005814:Genes, Viral; D006601:Hexoses / Q000378:metabolism; D009154:Mutation; D010960:Plasminogen Activators / Q000378:metabolism
D002352:Carrier Proteins; D005353:Fibronectins; D006601:Hexoses; D010960:Plasminogen Activators