A study of childhood renal tumours using xenogeneic antiserum.
Fifty-six primary childhood renal tumours, 14 normal and 12 fetal kidneys were examined for their staining reaction with xenogeneic anti-Wilms' antiserum. The antiserum was raised by injecting Wilms' tumour extracts into 6-month-old rabbits which had been rendered tolerant in utero with pooled normal kidney extracts. Renal carcinomas, mesoblastic nephroma and a large proportion of tubular wilms' tumours were stained by the antiserum. In contrast, 6 of 7 bone-metastasising renal tumours of childhood (BMRTC) failed to fluoresce when treated with the antiserum, suggesting that the BMRTC has a different origin from the other childhood renal tumours studied.
D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D001859:Bone Neoplasms / Q000556:secondary; D002648:Child; D005333:Fetus / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007668:Kidney / Q000276:immunology; D007680:Kidney Neoplasms / Q000276:immunology*; D007684:Kidney Tubules / Q000276:immunology; D009396:Wilms Tumor / Q000276:immunology*
D000951:Antigens, Neoplasm