title: Trimethadione effects on cholinergic responses in Aplysia neurons.
abstract: The anticonvulsant, trimethadione (TMO), was tested for effects on cholinergic responses to iontophoretic application of ACh on identified neurons in Aplysia. TMO (1--10 mM) depressed the amplitudes of depolarizing responses mediated by Na+ and hyperpolarizing responses mediated by Cl- but did not affect hyperpolarizing responses mediated by K+. Such a combination of effects on cholinergic responses distinguishes the action of this anti-absence drug from agents effective against tonic-clonic seizures and from convulsive drugs.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001048:Aplysia; D002712:Chlorides / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D005724:Ganglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D010080:Oxazoles / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012964:Sodium / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*; D014293:Trimethadione / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D010080:Oxazoles; D011950:Receptors, Cholinergic; D012964:Sodium; D000109:Acetylcholine; D014293:Trimethadione; D011188:Potassium