Modulation of FSH action by inhibin.
Both testicular and ovarian inhibin preparations caused a dose-related inhibition of binding of 125I-hFSH to rat testicular receptors. Testicular inhibin also suppressed the FSH-induced production of cAMP by rats testis in vitro. These data demonstrate a direct action of inhibin at the testicular level by interfering with FSH action.
D000818:Animals; D001414:Bacitracin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007265:Inhibins; D008297:Male; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D011962:Receptors, FSH; D013735:Testicular Hormones / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects*
D011506:Proteins; D011956:Receptors, Cell Surface; D011962:Receptors, FSH; D013735:Testicular Hormones; D001414:Bacitracin; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP