Clinical manifestation of adrenocorticotropin-determined plasma concentrations of mineralocorticoid hormones.
Chronic oversecretion of adrenocorticotropin (ACTH) in Cushing's disease and partial adrenal insufficiency results in a plasma pattern of mineralocorticoid hormones (MCHs) in which deoxycorticosterone, 18-hydroxycorticosterone and aldosterone remain within normal limits. In patients with deficiencies of 17 alpha- and 21-hydroxylation, the entire MCH pathway may be initially stimulated by ACTH alone in the presence of reduced cortisol production. An ACTH-induced intra-adrenal factor reflected by levels of cortisol production, or cortisol itself, may determine MCH levels by its inhibition (high) or lack of inhibition (low) of 11 beta- and 18-hydroxylation.
D000236:Adenoma / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood; D003480:Cushing Syndrome / Q000503:physiopathology; D003900:Desoxycorticosterone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007018:Hypopituitarism / Q000503:physiopathology; D008901:Mineralocorticoids / Q000097:blood*; D010911:Pituitary Neoplasms / Q000503:physiopathology; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood
D008901:Mineralocorticoids; D003900:Desoxycorticosterone; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012083:Renin; D011188:Potassium; D006854:Hydrocortisone