title: DNA methylation and the frequency of CpG in animal DNA.
abstract: An analysis of nearest neighbour dinucleotide frequencies and the level of DNA methylation in animals strongly supports the suggestion that 5-methylcytosine (5mC) tends to mutate abnormally frequently to T. This tendency is the likely cause of the CpG deficiency in heavily methylated genomes.
mesh_terms: D044503:5-Methylcytosine; D000818:Animals; D001483:Base Sequence; D003596:Cytosine / Q000031:analogs & derivatives* / Q000032:analysis; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes; D008745:Methylation; D009154:Mutation; D013941:Thymine / Q000032:analysis
chemical_list: D044503:5-Methylcytosine; D003596:Cytosine; D004247:DNA; D004262:DNA Restriction Enzymes; D013941:Thymine