title: Potential-dependent formation of single conducting ion channels in lipid bilayers induced by the polyene antibiotic levorin A.
abstract: The aromatic polyene antibiotic levorin A2 forms ion channels permeable to monovalent cations, in lipid membranes containing cholesterol or ergosterol. Channel conductivity is in the range 0.3-0.5 pS. The channel has two main states: conducting (open) and nonconducting (closed). The potential-dependent formation of levorin A2 channels is observed in lipid membranes. The system responsible for the ion-channel selectively is localized on the hydrophilic side of the lactone ring of the polyene molecule.
mesh_terms: D000935:Antifungal Agents; D002174:Candicidin; D004875:Ergosterol; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D008051:Lipid Bilayers; D008564:Membrane Potentials; D008954:Models, Biological; D010718:Phosphatidylserines
chemical_list: D000935:Antifungal Agents; D007473:Ion Channels; D008051:Lipid Bilayers; D010718:Phosphatidylserines; D002174:Candicidin; D004875:Ergosterol