Transmission in the squid giant synapse: a model based on voltage clamp studies.
1. Voltage clamp studies were performed in squid giant synapse after blockage of the voltage-dependent sodium and potassium conductances. 2. Presynaptic depolarization under these conditions demonstrates the presence of voltage-dependent calcium conductance change for the duration of the voltage step, and a tail current at the break of the pulse. 2. This calcium current triggers a postsynaptic response which can be measured directly at the postsynaptic fiber. 4. These voltage clamp experiments have allowed the development of a mathematical model that describes the kinetics of the calcium current and the relationship between calcium current and transmitter release.
D000818:Animals; D001369:Axons / Q000502:physiology; D002118:Calcium / Q000502:physiology; D049832:Decapodiformes / Q000502:physiology*; D004594:Electrophysiology; D008954:Models, Biological; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
D002118:Calcium