[Sternal plasmocytoma with monoclonal dysglobulinemia 28 months after a trauma. Pathogenic discussion (author's transl)].
A case of sternal plasmocytoma discovered 28 months after an occupational trauma is reported. At the first examination a small quantity of monoclonal IgG was present, and persisted in spite of a rather heavy treatment by irradiation and chemotherapy. To-day, more than eight years after the trauma, there is not any clinical or radiological sign of generalization, but bone marrow plasmocytosis is notably increased. Thus the long-dated prognosis is reserved. We discuss the frequency of solitary plasmocytomas of the sternum, the possibility of generalization sometimes after a very long delay, the relationship between the trauma and the plasmocytoma, the lack of pejorative significance of associated monoclonal dysglobulinemia. We suppose that in our case the dysglobulinemia antedated the trauma, this hypothesis is corresponding to the present concepts on oncogenesis, the trauma being only a cocarcinogenic agent.
D002999:Clone Cells / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000175:diagnosis*; D006801:Humans; D017099:IgG Deficiency; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000175:diagnosis*; D013249:Sternum; D013898:Thoracic Injuries; D013997:Time Factors
Plasmocytome sternal avec dysglobulinémie monoclonale apparu 28 mois après un traumatisme. Discussion pathogénique.