Effect of chronic lead treatment on GABA-ergic receptor function in rat brain.
The effect of chronic lead treatment on brain gamma-amino-butyric acid (GABA)-ergic function has been studied in an attempt to correlate the clinical aspects of the chronic exposure to the metal with specific neurochemical alterations. [3H]GABA-specific binding and cyclic guanosine monophosphate (GMP) content have been measured in various rat brain areas and have been found to be increased in cerebellum and decreased in the striatum of rats after chronic lead treatment. The changes found in the GABA-ergic neurons were correlated with the different levels of lead exposure in rats. Our results indicated that lead selectively affects GABA-ergic function in various rat brain areas, inducing effects which are dose-dependent.
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D005260:Female; D007700:Kinetics; D007854:Lead / Q000633:toxicity*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D007854:Lead; D005680:gamma-Aminobutyric Acid