title: Bone scanning in patients with early breast carcinoma: should it be a routine staging procedure?
abstract: Bone scanning is a sensitive test for the detection of metastatic breast cancer, but not all abnormal findings on bone scan are diagnostic of skeletal metastasis. Recent studies have found a relatively low rate (less than or equal to 5%) of abnormal scans in patients with Stage I and II breast cancers, and only half of those with positive scans subsequently had documented bony metastasis. The overwhelming clinical experiences summarized here question the value of including bone scanning as part of the routine work-up of patients with early breast cancers.
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000175:diagnosis*; D011756:Diphosphates; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005461:Fluorine; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013326:Strontium Radioisotopes; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate
chemical_list: D011756:Diphosphates; D011868:Radioisotopes; D013326:Strontium Radioisotopes; D005461:Fluorine; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium