Decrease of some metabolic and physiologic effects of diazoxide by propranolol in rat.
Diazoxide significantly decreased the blood pressure and relaxed the uterine muscle in anaesthetized normotensive rats. A marked elevation of blood glucose followed the intravenous injection of diazoxide. The hyperglycemic and the uterine relaxing response could be significantly decreased by injection of propranolol prior to diazoxide. The hypotensive effect was not diminished by propranolol, however. In liver and uterus the content of cAMP was increased following diazoxide treatment in vivo. The rise in cAMP could be completely inhibited by propranolol, indicating a beta-receptor stimulation being the cause of the cAMP elevation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D000242:Cyclic AMP / Q000032:analysis; D003981:Diazoxide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006943:Hyperglycemia / Q000139:chemically induced; D008099:Liver / Q000032:analysis; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000187:drug effects
D011433:Propranolol; D000242:Cyclic AMP; D003981:Diazoxide