Increased ouabain binding after repeated noradrenergic stimulation.
Acute noradrenergic stimulation has previously been shown to stimulate brain (Na+, K+)-adenosine triphosphatase activity. Effects of repeated stimulation with piperoxane were examined in the present study. Daily piperoxane increased ouabain binding, measured 24 h after the last dose, after 4 days or 3 weeks treatment; K+-p-nitrophenylphosphatase was increased after 3 weeks. Prazosin, which, like piperoxane, activates presynaptic noradrenergic neurons but, unlike piperoxane, blocks postsynaptic receptors, did not increase K+-p-nitrophenylphosphatase, and decreased ouabain binding after 3 weeks.
D009597:4-Nitrophenylphosphatase / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology*; D008297:Male; D010042:Ouabain / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology*; D010883:Piperoxan / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology*; D011485:Protein Binding; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats
D010880:Piperidines; D011799:Quinazolines; D010042:Ouabain; D010883:Piperoxan; D010744:Phosphoric Monoester Hydrolases; D009597:4-Nitrophenylphosphatase; D011224:Prazosin