Myofibroblasts in fibrous tumors and fibrosis in various organs.
The morphology and population of myofibroblasts detected by electron microscopy in fibrous tumors and fibrosis in various organs have been examined. The myofibroblast was identified by characteristic features of the indented nucleus, bundles of abundant microfilaments with dense bodies, focal basal lamina and well-developed rough endoplasmic reticulum. It has been observed that myofibroblasts in a variety of fibrous tumors and fibrosis appeared predominantly in fibromatosis and reparative process of deep fibrous tissues and organs particularly in the lesions involving the fascia and subcutaneous tissue. It was suggested that myofibroblasts would be modified fibroblasts to which fibroblasts in the fascia and deeply situated fibrous tissue transformed during proliferation and differentiation.
D000328:Adult; D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000648:ultrastructure; D002648:Child; D003599:Cytoskeleton / Q000648:ultrastructure*; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure*; D005350:Fibroma / Q000648:ultrastructure; D005354:Fibrosarcoma / Q000648:ultrastructure; D005705:Gallbladder Diseases / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000648:ultrastructure; D006801:Humans; D007889:Leiomyoma / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000648:ultrastructure*; D009372:Neoplasms, Connective Tissue / Q000648:ultrastructure*; D012595:Scleroderma, Systemic / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000648:ultrastructure; D014594:Uterine Neoplasms / Q000648:ultrastructure