Effect of ouabain on exogenous substrate oxidation by isolated cardiac myocytes.
Ouabain (10(-4) M) stimulated glucose oxidation and inhibited octanoate oxidation by isolated cardiac myocytes. Omission of potassium or calcium from the buffer abolished the ouabain stimulation of glucose oxidation. The inhibition of octanoate oxidation by ouabain persisted in the calcium deficient media.
D000818:Animals; D002210:Caprylates / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology*; D010084:Oxidation-Reduction; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002210:Caprylates; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose