Short-term effect of cyproterone acetate on testicular FSH binding in immature rats.
Male rats, aged 19 days, were injected with 1 mg cyproterone acetate, an antiandrogen, and killed 24 h later. In 9 out of 10 experiments this increased the apparent FSH-binding capacity by testicular tissue in vitro. In 4 out of 5 similar experiments, injection of 500 micrograms testosterone propionate caused a significant reduction in FSH binding. Observed changes were small but this does not preclude the possibility that androgens contribute to the physiological control of FSH receptor numbers.
D000818:Animals; D003534:Cyproterone / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D011962:Receptors, FSH; D012741:Sexual Maturation; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D011956:Receptors, Cell Surface; D011962:Receptors, FSH; D013739:Testosterone; D005640:Follicle Stimulating Hormone; D003534:Cyproterone