Stability of solid drugs: degradation of ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) at high humidities and elevated temperatures.
Ergocalciferol and cholecalciferol powders were studied at 25 and 40 degrees and at different humidities. Ergocalciferol decomposed rapidly at 25 and 40 degrees when stored in dry air. Decomposition of ergocalciferol led to the formation of products of higher polarity. Cholecalciferol was not as labile under dry conditions, but decomposed rapidly at high temperature.
D002762:Cholecalciferol / Q000032:analysis*; D004355:Drug Stability; D004872:Ergocalciferols / Q000032:analysis*; D006813:Humidity; D013696:Temperature
D004872:Ergocalciferols; D002762:Cholecalciferol