Alcohol inhibits morphological and biochemical differentiation of C6 glial cells in culture.
Cultures of glial cell lines (C6) were exposed to 10-micromilligram Dexamethasone which is known to cause morphological differentiation and induction of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) in these cells. Ethanol in a concentration of 1.5% abolished these responses, and at 1% diminished them.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003907:Dexamethasone / Q000037:antagonists & inhibitors; D000431:Ethanol / Q000494:pharmacology*; D005910:Glioma; D009457:Neuroglia / Q000166:cytology* / Q000201:enzymology; D051381:Rats
D000431:Ethanol; D003907:Dexamethasone; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases