Evidence that vasopressin is involved in the isoprenaline-induced beta-endorphin release.
We investigated in conscious rats, whether vasopressin, whose release was stimulated by isoprenaline (i.m.), caused the simultaneous increase in plasma beta-endorphin-like immunoreactivity (beta-EI). The increase in plasma beta-EI following isoprenaline administration was diminished by about 50% in rats pretreated with a vasopressin antagonist and also in rats with a hereditary absolute lack of vasopressin. We conclude that the isoprenaline-induced release of beta-EI is mediated in part by vasopressin.
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D003919:Diabetes Insipidus / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D014667:Vasopressins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001615:beta-Endorphin
D004723:Endorphins; D014667:Vasopressins; D001127:Arginine Vasopressin; D001615:beta-Endorphin; C028888:argipressin, deaminopenicillamine(1)-O-methyl-Tyr(2)-; D007545:Isoproterenol