Effects of dobutamine on cyclic AMP accumulation induced by the stimulation of dopamine receptors in rabbit retina in vitro.
Intact rabbit retinae were used for testing in vitro the potential activation of dopamine receptors by a new cardioactive sympathetic amine dobutamine. It was found that despite the structure relationship of dobutamine with other dopamine-analog, the pharmacological action of this compound is not comparable to that of apomorphine, N-methyl-dopamine and/or ADTN.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002395:Catecholamines / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D003846:Deoxyepinephrine / Q000494:pharmacology; D004280:Dobutamine / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005476:Fluphenazine / Q000494:pharmacology*; D011817:Rabbits; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D012160:Retina / Q000187:drug effects / Q000378:metabolism*
D002395:Catecholamines; D011954:Receptors, Dopamine; D004280:Dobutamine; D000242:Cyclic AMP; D001058:Apomorphine; D003846:Deoxyepinephrine; D005476:Fluphenazine; D004298:Dopamine