title: M-response quantification: a technique.
abstract: Median nerve responses in 13 patients and 9 normal subjects were evaluated using surface bipolar stimulation. The M response from surface electrodes placed upon the thenar eminence was recorded on a fiberoptic chart recorder and simultaneously subjected to true electronic integration. Comparison between the integrated M response and the M index (the product of the M response peak-to-peak amplitude and total duration) revealed a highly correlated linear regression. This linear relationship was present when stimulating both at the wrist (r2 = 0.96) and the antecubital fossa (r2 = 0.95). Statistically significant differences were observed between the integrated M response of 5 normal adult men and men with carpal tunnel syndrome (n 3, p less than 0.01) or anterior horn cell or neuropathic processes (n 4, p less than 0.001). Differences of borderline significance were noted between normal women (n = 4) and women with carpal tunnel syndrome (n 4, p less than 0.05) or anterior horn cell or neuropathic processes (n 2, p less than 0.01). There was no correlation between the integrated M response and the distal latency in patients with carpal tunnel syndrome. It is concluded that the M index is a highly reliable method of quantifying the M response as an approximation of integration in median nerve studies, but that this measurement holds little relationship with the presence of the distal neuropathic processes studied.
mesh_terms: D000328:Adult; D000368:Aged; D002349:Carpal Tunnel Syndrome / Q000503:physiopathology; D004558:Electric Stimulation; D004576:Electromyography / Q000379:methods; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000503:physiopathology*; D008875:Middle Aged; D009046:Motor Neurons; D009468:Neuromuscular Diseases / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000503:physiopathology*