Alterations in beta 1- and beta 2-adrenergic receptor density in the cerebellum of aging rats.
The densities of beta 1 and beta 2-adrenergic receptors were determined in homogenates of cerebral cortex and cerebellum of rats between 3 and 14 mo of age. No change in either receptor population occurred in the cortex during this period. In the cerebellum, a 20--25% decrease in the density of beta 2 receptors and a 350% increase in the density of beta 1 receptors occurred. The increase in beta 1 receptors in the cerebellum may be the result of a decrease in the function of the noradrenergic projections from the locus coeruleus which synapse on cerebellar Purkinje cells.
D000375:Aging; D000818:Animals; D002531:Cerebellum / Q000254:growth & development* / Q000378:metabolism; D002540:Cerebral Cortex / Q000254:growth & development / Q000378:metabolism; D005260:Female; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta