title: Transmitter sensitivity of neurons assayed by autoradiography.
abstract: Ionic conductance channels that are opened by activating nicotinic acetylcholine receptors at synapses of sympathetic neurons are permeable to small organic amines. Uptake of a tritium-labeled amine through these channels can be measured by autoradiography. This provides a simple and direct way to assess the sensitivity of individual neurons to acetylcholine without using microelectrodes.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000376:Agmatine; D000818:Animals; D001345:Autoradiography / Q000379:methods; D002463:Cell Membrane Permeability / Q000187:drug effects; D006146:Guanidines; D007473:Ion Channels / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D011898:Ranidae; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*
chemical_list: D006146:Guanidines; D007473:Ion Channels; D010277:Parasympathomimetics; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D009538:Nicotine; D000376:Agmatine; D000109:Acetylcholine