title: The effects of epidermal growth factor on the cyclic nucleotide system in pig epidermis.
abstract: Incubation of pig skin slices with epidermal growth factor (EGF) caused an increase in intracellular cyclic GMP concentration. A significant increase was found after 1 hr of incubation and reached a peak by 6 hr. EGF caused no change in the cyclic AMP level nor did it affect epinephrine-induced cyclic AMP responses.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D066298:In Vitro Techniques; D010455:Peptides / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D013552:Swine
chemical_list: D010455:Peptides; D004815:Epidermal Growth Factor; D000242:Cyclic AMP; D006152:Cyclic GMP