[Dynamics of bacterial populations in experimental destructive pulmonary tuberculosis under treatment].
An experimental model of cavitary tuberculosis in the animal was used, induced in rabbits, guinea-pigs or rats, and the effect of three therapeutic regimens was followed, that contained the tuberculostatics listed below: -- INH + RMP + protinamide (I); - INH + RMP + SM (II); - INH (III). In the animals that were sacrificed periodically a quantitative evaluation was made, by seeding of organ samples in culture media, of the dynamics of bacterial populations isolated at 1, 3 and 5 months after the start of the treatment. The best results were obtained with the therapeutic regimen nr. II. The association of INH to RMP leads to a rapid decrease in the number of germs. The complete recovery of the animals however was not obtained, according to histological and bacteriological criteria.
D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification; D011817:Rabbits; D051381:Rats; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology
D000995:Antitubercular Agents
Dinamica populaţiilor bacteriene în tuberculoza pulmonară distructivă experimentală sub tratament.