title: Prostatic origin of fucosyl transferase in human seminal plasma--a study on healthy controls and on men with infertility or with prostatic cancer.
abstract: Fucosyl transferase was recovered in soluble form in human seminal plasma. The enzyme had very little activity, as it was structurally bound to prostasomes, which are membrane-surrounded organelles in seminal plasma. The fucosyl transferase activity was recorded on Sephadex G200 chromatography of seminal plasma (supernatant after ultracentrifugation) in one single peak coinciding with that of prostate-specific acid phosphatase. Studies on healthy men and on men with prostatic cancer suggest a prostatic origin of fucosyl transferase activity; two of the men with prostatic cancer displayed 50-95% decreased activities. Antiandrogenic therapy in another man with cancer resulted in substantial reductions in seminal plasma contents of fucosyl transferase, ATPase, acid phosphatase and fructose suggesting a role of testosterone in their secretions.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D005632:Fructose / Q000378:metabolism; D005647:Fucosyltransferases / Q000378:metabolism*; D006602:Hexosyltransferases / Q000378:metabolism*; D006801:Humans; D007248:Infertility, Male / Q000201:enzymology*; D008297:Male; D011467:Prostate / Q000201:enzymology*; D011471:Prostatic Neoplasms / Q000201:enzymology*; D012661:Semen / Q000166:cytology / Q000201:enzymology*; D012799:Sialyltransferases / Q000378:metabolism; D014659:Vasectomy; D015032:Zinc / Q000378:metabolism
chemical_list: D005632:Fructose; D005647:Fucosyltransferases; D006602:Hexosyltransferases; D012799:Sialyltransferases; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D015032:Zinc