Alterations in the latency of hepatic microsomal hexose-6-phosphate dehydrogenase under various in vivo and in vitro conditions.
To gain insight into the cause of the latency of microsomal hexose-6-phosphate dehydrogenase activity, changes in the activity and latency of hexose-6-phosphate dehydrogenase were examined to determine whether they were parallel to those of other microsomal enzymes (UDP glucuronyltransferase, nucleoside diphosphatase and glucose-6-phosphatase) during development and after treatments of rats with phenobarbital and a high carbohydrate diet. We also examined whether the latency of hexose-6-phosphate dehydrogenase could be ascribed to changes in the cholesterol content and phospholipid composition of microsomes under various conditions. The results show that the activities and latencies of the four microsomal enzymes change independently during development and after various treatments, and that the phospholipid composition of microsomes does not have any direct effect on the latency of hexose-6-phosphate dehydrogenase.
D017766:Acid Anhydride Hydrolases; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000494:pharmacology; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism; D007425:Intracellular Membranes / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D051381:Rats; D010738:Type C Phospholipases / Q000378:metabolism
D004040:Dietary Carbohydrates; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D002784:Cholesterol; D005954:Glucosephosphate Dehydrogenase; D014453:Glucuronosyltransferase; D010744:Phosphoric Monoester Hydrolases; D005952:Glucose-6-Phosphatase; D010738:Type C Phospholipases; D017766:Acid Anhydride Hydrolases; C023837:nucleoside-diphosphatase; D010634:Phenobarbital