title: [Transferable tetracycline resistance in "Clostridium difficile" (author's transl)].
abstract: Tetracycline (Tc) resistance is transferable from a resistant strain of Clostridium difficile to a sensitive strain and this resistance is not curable. Resistances to erythromycin and clindamycin are curable but not transferable. These results suggest for these resistances a plasmid determinism. It is shown that a plasmid-mediated Tc resistance (pIP401) of C. perfringens is also transferable to C. difficile. Tc resistance is inducible in C. perfringens and constitutively expressed in C. difficile. In the Tc-resistant transcipients of C. difficile this resistance is either inducible or constitutive, whether the Tc-resistant donor strain was C. perfringens or C. difficile.
mesh_terms: D002981:Clindamycin / Q000494:pharmacology; D003013:Clostridium / Q000187:drug effects / Q000235:genetics*; D003016:Clostridium perfringens / Q000187:drug effects / Q000235:genetics; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D010957:Plasmids; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D002981:Clindamycin; D004917:Erythromycin; D013752:Tetracycline
vernacular_title: Transfert de la résistance à la tétracycline chez Clostridium difficile.