Paradoxical effect of naloxone on nitrous oxide analgesia in man.
The effect of naloxone on nitrous oxide analgesia in man has been investigated. The paradoxical response so obtained indicates the possibility of a dural system mediating the pain response in man. These results support previous animal experiments indicating that nitrous oxide analgesia is mediated by the opiate receptors.
D000328:Adult; D000698:Analgesia; D004347:Drug Interactions; D004357:Drug Synergism; D004723:Endorphins / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009609:Nitrous Oxide / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D009609:Nitrous Oxide