Leaky +1 and -1 frameshift mutations at the same site in a yeast mitochondrial gene.
Two mutations in a mitochondrial structural gene, which cause leaky premature polypeptide chain termination and leaky growth, are +1 and -1 frameshifts in the same run of five T residues. The partial restoration of reading frame is probably due to ribosomal frameshifting at this site, and may be promoted by the unique structure of the yeast mitochondrial t RNAPhe.
D004272:DNA, Mitochondrial / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000235:genetics; D005796:Genes; D009154:Mutation; D010641:Phenotype; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000235:genetics; D012270:Ribosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D004272:DNA, Mitochondrial; D012343:RNA, Transfer; D003576:Electron Transport Complex IV