[Cefotaxime: a semi-synthetic cephalosporin of the new generation (author's transl)].
The important structural feature of the new cephalosporin derivative, cefotaxime, is the conjunction in the acetyl side - chain of the aminothiazolyl ring and the - syn - methoxyimino group. The aminothiazoloacetyl side - chain improves antibacterial properties against Gram negative bacilli, while the adjunction of the methoxyimino substituent is responsible for the further unexpectedly large increase in activity.
D001419:Bacteria / Q000187:drug effects; D002439:Cefotaxime; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002511:Cephalosporins; D002439:Cefotaxime
Le céfotaxime, céphalosporine d'hémi-synthèse de la nouvelle génération.