[Susceptibility of rat thymocyte subpopulations to thymosine affecting their protein synthesis and dexamethasone receptors].
Protein synthesis and reception for 1,2-3H-(N)-dexamethasone were studied in A, B, C, D subpopulations of rat thymocytes after treatment with thymosine, cyclic adenosine-3,' 5'-monophosphate (cAMP) and caffeine. Thymosine inhibited the 1,2-3H-(N)-dexamethasone reception in rat thymocyte subpopulations A, B and C by 30-40%, stimulated the protein synthesis in A and B fractions by 30% as well as inhibited the synthesis in D fraction by 14%. Caffeine, administered together with thymosine, inhibited the protein synthesis by 80% in C and D thymocyte subpopulations and - by 47% in B subpopulations. After simultaneous treatment with exogenous cAMP, thymosine and caffeine the protein synthesis was inhibited by 14% in all the thymocyte subpopulations. The data obtained suggest that thymosine and caffeine affect the various lymphocyte T subpopulations, dissimilar in their differentiation.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D003907:Dexamethasone / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D013947:Thymosin / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013951:Thymus Hormones / Q000494:pharmacology*
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D013951:Thymus Hormones; C028697:dexamethasone receptor; D002110:Caffeine; D013947:Thymosin; D003907:Dexamethasone; D000242:Cyclic AMP
Kharakteristika subpopuliatsii timotsitov krys po chuvstvitel'nosti k deĭstviiu timozina na sintez belka i retseptsiiu deksametazona.