Intracranial growth of pulmonary small cell carcinoma cells in nude athymic mice.
Pulmonary small cell carcinoma of the lung cells were inoculated intracranially and subdermally in nude athymic mice (Balb/c strain). There was a 100% intracranial tumor incidence in response to 1/10th the cell dose required to produce subdermal tumors in immunosuppressed nude mice. Tumors did not grow in the brains of Balb/c normal (haired) mice.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001932:Brain Neoplasms / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000473:pathology*; D002460:Cell Line; D002467:Cell Nucleus / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum