[Effect of different doses of diphtheria exotoxin on the properties of L929 and HeLa cells].
Various forms of interaction between diphtheria exotoxin and the continuous L and HeLa cell lines were revealed, depending on its doses: toxic, subtoxic and small (following the subtoxic dose). Cells of the same origin, treated with these doses, develop similar changes in some of their properties, differing only in their "survival" time, the period of adaptation and the time of entering the phase of active proliferation. the systems of cells, having simultaneously low susceptibility to infection with some RNA-containing viruses (L cells with low susceptibility to vesicular stomatitis virus and HeLa cells with low susceptibility to Coxsackie B5 virus) and high susceptibility to repeated treatment with diphtheria exotoxin, have been obtained.
D000818:Animals; D002403:Cathepsins / Q000378:metabolism; D002470:Cell Survival; D002999:Clone Cells; D004167:Diphtheria Toxin / Q000008:administration & dosage / Q000506:poisoning*; D029822:Enterovirus B, Human / Q000472:pathogenicity; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007739:L Cells; D051379:Mice; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus / Q000472:pathogenicity
D004167:Diphtheria Toxin; D002403:Cathepsins
Deĭstvie razlichnykh doz difteriĭnogo ĕkzotoksina na svoĭstva kletok L929 i HeLa.