Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.
Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.
D000262:Adenylyl Cyclases / Q000378:metabolism; D001254:Astrocytoma; D002460:Cell Line; D002499:Centrifugation, Density Gradient; D003208:Concanavalin A / Q000494:pharmacology; D004705:Endocytosis; D006801:Humans; D007545:Isoproterenol / Q000378:metabolism*; D011487:Protein Conformation; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013997:Time Factors
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D003208:Concanavalin A; D000262:Adenylyl Cyclases; D007545:Isoproterenol