title: Electrophysiological abnormalities in chronic epileptogenic foci: an intracellular study.
abstract: Intracellular recordings were performed from chronic cobalt epileptogenic foci in rats. Two main features were found: (a) in 29% of the neurons, depolarizations of long duration occurred coinciding with cortical surface paroxysms; and (b) in 13% of the neurons, partial spikes, whose amplitude varied little with membrane DC potential changes, occurred. It is suggested that these phenomena have a dendritic origin, and possible mechanisms underlying the generation of paroxysmal events are discussed.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D003035:Cobalt / Q000633:toxicity; D005071:Evoked Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology; D011712:Pyramidal Tracts / Q000503:physiopathology; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D003035:Cobalt