Antiherpesviral activity and inhibitory action on cell growth of 5-alkenyl derivatives of 1-beta D-arabinofuranosyluracil.
Antiherpesviral activity of 5-vinyl-1-beta-D-arabinofuranosyluracil was as high as that of 1-beta-D-arabinofuranosylthymine, whereas the former was less inhibitory to cell growth than the latter. 5-Propenyl- and 5-butenyl-1-beta-D-arabinofuranosyluracil were less active than 5-vinyl-1-beta-D-arabinofuranosyluracil.
D000998:Antiviral Agents / Q000494:pharmacology*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives*; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D014529:Uridine / Q000031:analogs & derivatives*
D000998:Antiviral Agents; D001086:Arabinofuranosyluracil; D014529:Uridine