Inhibition of AKR leukemogenesis by SMX-1, a dualtropic murine leukemia virus.
Intrathymic injection of SMX-1, a dualtropic murine leukemia virus (MuLV) originally derived from Moloney murine leukemia virus stocks, protects AKR mice from developing MuLV-accelerated leukemia and spontaneous leukemia. Thymuses of SMX-1-injected mice show no change in weight, morphology, or thymocyte size, and quantitative expression of Thy-1 and Lyt-2 differentiation antigens is identical to control mice. The amplified thymic expression of MuLV-related antigens that occurs spontaneously in 6-month-old preleukemic AKR mice or that can be induced in young AKR mice by leukemogenic AKR dualtropic MuLV is prevented by SMX-1. It appears unlikely that the protective effect of SMX-1 is explicable in terms of cross-immunogenicity with transforming MuLV or transformed cells. As SMX-1 persists for long periods after intrathymic injection and does not alter levels of thymic ecotropic MuLV, SMX-1 may interfere with the generation, spread, or leukemogenicity of dualtropic MuLV that form de novo in AKR thymus during the late preleukemic phase. SMX-1 provides a way to probe the events leading to cell transformation in AKR mice.
D000406:AKR murine leukemia virus; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis / Q000096:biosynthesis; D001835:Body Weight; D005260:Female; D009052:Leukemia Virus, Murine / Q000254:growth & development; D007942:Leukemia, Experimental / Q000517:prevention & control*; D051379:Mice; D008806:Mice, Inbred AKR / Q000382:microbiology*; D008979:Moloney murine leukemia virus; D009017:Morbidity; D009929:Organ Size; D013950:Thymus Gland / Q000166:cytology; D013997:Time Factors; D014762:Viral Interference
D000951:Antigens, Neoplasm