title: Acycloguanosine treatment of herpesvirus infections in footpads and nervous tissue of normal and immunosuppressed mice.
abstract: Treatment of herpes simplex virus type 1 (HSV-1)-infected mice with acycloguanosine resulted in significantly fewer virus isolates from nervous tissues than from tissues of untreated animals. Acycloguanosine also significantly reduced the mean titers of HSV-1 recovered from the footpads of drug-treated animals. The anti-herpetic activity of acycloguanosine was observed in both normal and immunosuppressed mice.
mesh_terms: D000212:Acyclovir; D000818:Animals; D001921:Brain / Q000382:microbiology; D002490:Central Nervous System / Q000382:microbiology*; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006561:Herpes Simplex / Q000188:drug therapy* / Q000382:microbiology; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D012584:Sciatic Nerve / Q000382:microbiology; D018139:Simplexvirus / Q000302:isolation & purification*; D013116:Spinal Cord / Q000382:microbiology
chemical_list: D006147:Guanine; D000212:Acyclovir