title: Influence of unilateral olfactory bulbectomy on opiate and other binding sites in the contralateral bulb.
abstract: The neurochemical consequences of unilateral olfactory bulbectomy (UBX) in mice were determined in the remaining olfactory bulb at various times after surgery. The most significant finding was a progressive decline in opiate ligand (dihydromorphine) and naloxone) binding that appeared within 11 days after surgery and persisted throughout the study. Statistically significant declines in spiroperidol (-67%), clonidine (-48%) and muscimol (-16%) binding were also observed 90 days after surgery. At 180 days postsurgery we observed a 20% increase in diazepam binding. No effect of UBX on dihydroalprenolol, quinucludinylbenzilate or serotonin ligand binding was observed. Bulbectomy resulted in a moderate decrease (-28%) in DOPA decarboxylase activity 14 days after surgery, which returned to normal by 30 days. Glutamic acid decarboxylase activity decreased by 37% 7 days after UBX, returned to normal by 14 days after surgery and then increased by 25% 90 days after UBX. Unilateral bulbectomy had no effect on cholineacetyltransferase activity in the remaining bulb. Thus, following a unilateral procedure, one bulb cannot necessarily serve as a valid control for the other. Possible explanations for the neurochemical changes observed are discussed.
mesh_terms: D000818:Animals; D003714:Denervation; D004090:Dihydromorphine / Q000378:metabolism; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D051379:Mice; D009270:Naloxone / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism*; D009833:Olfactory Pathways / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism*
chemical_list: D011957:Receptors, Opioid; D009270:Naloxone; D004090:Dihydromorphine