Influence of intracellular injection of H+ on the electrical coupling in cardiac Purkinje fibres.
The effect of intracellular injection of H+ on the electrical coupling of canine Purkinje cells was investigated. It was found that H+ increased the intracellular resistance (ri) and caused electrical uncoupling. The effect of high (H+)i on cell communication was partially reverted by intracellular injection of EDTA. These observations seem to indicate that the effect of low pHi on the electrical coupling can be explained, at least in part, by a rise in free [Ca2+]i. Further studies are required.
D000818:Animals; D002118:Calcium / Q000502:physiology; D002450:Cell Communication; D004285:Dogs; D004492:Edetic Acid / Q000494:pharmacology; D006329:Heart Conduction System / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007365:Intercellular Junctions / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D011690:Purkinje Fibers / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects
D004492:Edetic Acid; D002118:Calcium