Human nasopharyngeal carcinomas positive for Epstein-Barr virus DNA in North America.
Nasopharyngeal carcinomas (NPC) from 2 black patients and 1 Caucasian patient were positive for Epstein-Barr virus (EBV) DNA. Of the tumors, 2 were lymphoepitheliomas (undifferentiated NPC) and 1 was a moderately differentiated NPC. All 3 patients had high IgG titers against EBV early antigen and high IgG and IgA titers against virus capsid antigen (VCA). In one patient, the levels of anti-VCA IgA were different than those of anti-VCA IgG over the course of the disease. Our data support the association of EBV and NPC in North America.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002277:Carcinoma / Q000382:microbiology*; D002294:Carcinoma, Squamous Cell / Q000382:microbiology; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D004854:Herpesvirus 4, Human / Q000032:analysis* / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000382:microbiology*; D009656:North America; D009695:Nucleic Acid Renaturation
D000914:Antibodies, Viral; D004273:DNA, Neoplasm; D004279:DNA, Viral