[Correction of the T immunological system deficit in experimental and clinical tuberculosis].
Thymus grafts, in semi-permeable chambers, from 7-10 day old white rats to guinea-pigs infected with M. tuberculosis, or to white rats that had underwent thymectomy and had been infected, is accompanied by a considerable decrease in the severity of the tuberculous process. A similar effect is obtained by the subcutaneous injection of a thymus preparation called Timalin. The addition to etiotropic therapy of the immunostimulant Levamisole in amounts of 2,5 mg/kg of body weight in white rats, and of 25 mg/kg of body weight in guinea-pigs, three times during a decade significantly enhanced the effect of the conventional therapy. Levamisole, when included in the complex therapy of tuberculosis patients (three times during a decade), accelerated the detoxification process, and the recovery of recent destructive lesions in the lung. In animals and in patients Levamisole increases the low activity of the T-lymphocytes immune system, as is indicated by data obtained with the leucocyte migration inhibition test, and with the rosette-formation test.
D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D007978:Levamisole / Q000627:therapeutic use*; D051381:Rats; D013601:T-Lymphocytes; D013934:Thymectomy; D013949:Thymus Extracts / Q000627:therapeutic use*; D013950:Thymus Gland / Q000637:transplantation*; D014184:Transplantation, Homologous; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D013949:Thymus Extracts; D007978:Levamisole
Corectarea deficitului sistemului imunitar T în tuberculoza experimentală şi clinică.