Antioncogenic activity of influenza virus on polyoma virus induced renal and brain tumors in newborn Wistar rats.
Simultaneous inoculation of newborn Wistar rats with intact A/PR 8/34 (HON 1) influenza virus and the S.E. strain of polyoma virus resulted in significant reduction of the rates of both kidney sarcomas and brain tumors in comparison to controls given polyoma virus, only. This antioncogenic activity (AOA) of influenza virus was observed independently whether or not influenza and polyoma virus were injected on different sites or were inoculated as a combined vaccine. Ether-treated A/PR 8/34 influenza virus was found to have also AOA. However, in one experiment a significant AOA was demonstrated with respect to brain tumors, only, and not for the rate of renal sarcomas. In addition, the influenza strain A/Hong Kong/1/68 (H3N2) was found to have AOA.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D001932:Brain Neoplasms / Q000517:prevention & control*; D006391:Hemangioma / Q000517:prevention & control; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines; D007680:Kidney Neoplasms / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000517:prevention & control; D011120:Polyomavirus / Q000254:growth & development* / Q000276:immunology; D012513:Sarcoma, Experimental / Q000517:prevention & control
D000914:Antibodies, Viral; D007252:Influenza Vaccines