Increased feeding and hyperglycemia elicited by intracerebroventricular 5-thioglucose.
5-Thioglucose (5-TG) is a glucose analogue in which sulfur is substituted for the pyranose ring oxygen. Intracerebroventricular infusion of 5-TG caused prompt initiation of feeding and a marked rise in plasma glucose concentration at doses as low as 0.54 mumol (106 microgram). 5-TG is, therefore, more potent for eliciting feeding than any other previously tested glucose antimetabolite. The potency of 5-TG for eliciting feeding should make 5-TG a useful tool for localizing brain glucoreceptors which participate in the control of food intake.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003847:Deoxyglucose / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*
D001786:Blood Glucose; D011956:Receptors, Cell Surface; C027786:glucose receptor; C003002:5-thio-D-glucose; D003847:Deoxyglucose; D005947:Glucose