[In vitro effects of glycolytic substrates and some nucleotides (ATP, ADP, AMP, cyclic AMP) on the motility of spermatozoids of human sperm, asthenospermic or normal].
The effects of several drugs upon normal and asthenospermic human sperms were tested: cyclic AMP significantly and constantly increased the rate of motile spermatozoa in most samples having an initial motility rate between 20 and 60%. ATP kept up high the motility rate, particularly in sperm displaying the highest initial motility. Other drugs (glycolytic substrates, pyruvate, ADP, AMP, caffeine had inconstant effects upon a few sperms. None drug was efficient upon sperms with initial motility rate lower than 20%; this was probably due to important lesions of the locomotor apparatus of the spermatozoa, as shown by electron microscopy investigations.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000249:Adenosine Monophosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D005632:Fructose / Q000494:pharmacology*; D005636:Fructosephosphates / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D009845:Oligospermia / Q000503:physiopathology*; D011773:Pyruvates / Q000494:pharmacology; D012016:Reference Values; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000502:physiology*
D000227:Adenine Nucleotides; D005636:Fructosephosphates; D011773:Pyruvates; D005632:Fructose; D002110:Caffeine; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000242:Cyclic AMP
Action de substrats glycolysables et de divers nucléotides (ATP, ADP, AMP, AMPc) sur la motilité in vitro des spermatozoïdes de spermes humains, asthénospermiques ou non.