Na+ independent binding of [3H] muscimol to a membrane fraction of the brains of normal and dwarf mice.
Although their body weights were decreased by about 77% and their brain weights by about 30%, high-affinity [3H] muscimol binding to a cerebral membrane fraction was not altered in hereditary pituitary dwarf mice. Marked changes in the level of pituitary growth-associated hormones do not appear to be associated with a change in cerebral GABA-receptors.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004393:Dwarfism, Pituitary / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D009118:Muscimol / Q000378:metabolism*; D009929:Organ Size; D010080:Oxazoles / Q000378:metabolism*; D011955:Receptors, Drug / Q000187:drug effects / Q000378:metabolism*; D011963:Receptors, GABA-A; D012964:Sodium / Q000494:pharmacology*
D010080:Oxazoles; D011955:Receptors, Drug; D011963:Receptors, GABA-A; D009118:Muscimol; D012964:Sodium