Effect of iohexol, metrizamide and ioxaglate on the blood-brain barrier.
The effect upon the blood-brain barrier of the non-ionic contrast medium iohexol, compared with that of ioxaglate and metrizamide, was analysed. The contrast media were injected selectively into the internal carotid arteries of rabbits, and 197Hg Ac2 and Trypan blue were used as markers for evaluation of the injury. Less injury to the blood-brain barrier was caused by iohexol.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000473:pathology; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D007269:Injections, Intra-Arterial; D007463:Iodobenzoates / Q000494:pharmacology*; D007472:Iohexol; D007485:Ioxaglic Acid; D008297:Male; D008631:Mercury Radioisotopes; D008793:Metrizamide / Q000494:pharmacology*; D011817:Rabbits; D014283:Triiodobenzoic Acids / Q000494:pharmacology*; D014343:Trypan Blue
D003287:Contrast Media; D007463:Iodobenzoates; D008631:Mercury Radioisotopes; D014283:Triiodobenzoic Acids; D007472:Iohexol; D014343:Trypan Blue; D008793:Metrizamide; D007485:Ioxaglic Acid