[Aldosterone production in vitro by angiotensin II: the role of Ca++].
In beef isolated and superfused adrenal glands, the Authors have studied the production of aldosteron and tissue concentration of cAMP during superfusion with angiotensin II alone or preceededby preincubation with indomethacin or verapamil. In such experimental conditions the Authors could evidence that th aldosterone-inductor effect of angiotensin II is not mediated by cAMP but by PGs and Ca++.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000450:Aldosterone / Q000096:biosynthesis*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002417:Cattle; D000242:Cyclic AMP / Q000378:metabolism; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D010477:Perfusion; D011453:Prostaglandins / Q000502:physiology; D014700:Verapamil / Q000494:pharmacology
D011453:Prostaglandins; D000804:Angiotensin II; D000450:Aldosterone; D014700:Verapamil; D000242:Cyclic AMP; D002118:Calcium; D007213:Indomethacin
Produzione di aldosterone in vitro da angiotensina II: ruolo de Ca++.