title: Simple beta-lactam compounds derived from 6-aminopenicillanic acid.
abstract: As part of a general program of structural modification in beta-lactam antibiotics, we have synthesized several simple penicillins from 6-aminopenicillanic acid where the C-3 carboxyl group has been replaced by a hydroxy or an acetoxy group and the C-6 side chain has been substituted by bromine or hydrogen. Some of the compounds exhibit mild activity against the Gram-positive strain Bacillus subtilis.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives; D010406:Penicillins / Q000138:chemical synthesis* / Q000494:pharmacology; D047090:beta-Lactams
chemical_list: D010406:Penicillins; D047090:beta-Lactams; D010397:Penicillanic Acid; C004408:aminopenicillanic acid