Comparative therapeutic effects of vitamin D3 and its derivatives on experimental renal osteodystrophy.
The comparative effectiveness of vitamin D3 and its derivatives in curing hyperparathyroidism and osteodystrophic bone lesions was examined in a laboratory model of renal osteodystrophy associated with marked secondary hyperparathyroidism in rats. The experimental model was prepared by a single injection of homologous glycopeptide. Plasma levels of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] appeared to decrease in the rats receiving glycopeptide. Various doses of vitamin D3 derivatives [2 or 10 microgram/kg D3, 2 microgram/kg 25-hydroxyvitamin D3 (25OHD3), 0.1 microgram/kg 1 alpha,25(OH)2D3, and 0.1 or 0.2 microgram/kg 1 alpha-hydroxyvitamin D3 (1 alpha OHD3)] were daily administered orally to the nephritic rats for 23 days before sacrifice. 1 alpha,25(OH)2D3 and 1 alpha OHD3 were much more potent than 25OHD3 and D3 in reducing the hyperplasia of parathyroir glands. The potency of 1 alpha OHD3 in curing the histological changes of osteodystrophy appeared to be greater than that of 1 alpha,25(OH)2D3. The same dose level of 1 alpha OHD3 was more effective than 1 alpha,25(OH)2D3 in enhancing plasma 1 alpha,25(OH)2D3 levels.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D002762:Cholecalciferol / Q000494:pharmacology / Q000627:therapeutic use*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004100:Dihydroxycholecalciferols / Q000494:pharmacology; D004195:Disease Models, Animal; D006020:Glycopeptides; D006887:Hydroxycholecalciferols / Q000494:pharmacology; D010280:Parathyroid Glands / Q000187:drug effects; D010281:Parathyroid Hormone / Q000097:blood; D051381:Rats; D013329:Structure-Activity Relationship
D004100:Dihydroxycholecalciferols; D006020:Glycopeptides; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D002762:Cholecalciferol; D002118:Calcium