title: Inhibition of prolyl hydroxylase activity in the aorta of rats by propranolol in vitro.
abstract: The enzyme of prolyl hydroxylase was prepared from the rat aorta. The prolyl hydroxylase activity was measured by the tritium release assay in vitro. Propranolol at concentrations of 3 X 10(-6)M, 10(-5)M inhibited the prolyl hydroxylase activity by 20.6%, 69.8% and 93.7% of control activity, respectively, when the reaction mixtures were incubated for 30 min. It is suggested that propranolol may exert some influence on the collagen biosynthesis of the blood vessels.
mesh_terms: D000818:Animals; D001011:Aorta / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000037:antagonists & inhibitors*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats
chemical_list: D011433:Propranolol; D011393:Procollagen-Proline Dioxygenase