[Production of anti-idiotypic monoclonal antibodies that recognize the receptor for murine gamma interferon].
In this work we consider the possibility to produce a monoclonal antibody against murine interferon gamma receptor using an approach based on the anti-idiotypic network theory of Jerne. We have found a rat monoclonal antibody (C-28) directed against the combining site of AN-18, a rat monoclonal antibody neutralizing murine interferon gamma activity, that is able to bind interferon receptor.
D000818:Animals; D000911:Antibodies, Monoclonal; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007371:Interferon-gamma / Q000378:metabolism*; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D011971:Receptors, Immunologic / Q000276:immunology*; D017471:Receptors, Interferon
D000911:Antibodies, Monoclonal; D007130:Immunoglobulin Idiotypes; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D007371:Interferon-gamma
Produzione di anticorpi monoclonali anti idiotipo che riconoscono il recettore per l'interferon gamma murino.