Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro.
The appearance of acetylcholinesterase (AChE) at newly formed nerve-muscle synapses depends on synaptic transmission. Synapses form when cultures are grown in the presence of acetylcholine receptor antagonists, but AChE does not accumulate at these synapses. The important component of transmission seems to be muscle activity. Treatment with dibutyryl cyclic GMP mimics muscle activity, directly inducing synaptic AChE appearance.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology; D002478:Cells, Cultured; D002642:Chick Embryo; D003472:Curare / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000201:enzymology*; D011950:Receptors, Cholinergic / Q000378:metabolism; D013116:Spinal Cord / Q000166:cytology; D013570:Synaptic Membranes / Q000187:drug effects / Q000201:enzymology; D009435:Synaptic Transmission
D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D003995:Dibutyryl Cyclic GMP; D003472:Curare; D000110:Acetylcholinesterase