[Age and the effect of adrenocorticotropic hormone on aldosterone secretion in rats].
Age-related changes in functional activity of the glomerular zone were studied in the adrenal cortex of Wistar rats. It was shown that secretion of the basic mineralocorticoid hormone aldosterone was decreased with age. The glomerular zone of old rats showed the reduced sensitivity to the stimulant action of corticotropin, marked by the pronounced reaction to less doses of the hormone administered. At the same time the reactivity and the range of shifts in the course of ACTH dosage build-up decrease with aging.
D000302:Adrenal Cortex / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000367:Age Factors; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical
D000450:Aldosterone; D000324:Adrenocorticotropic Hormone
Vozrastnye osobennosti vliianiia adrenokortikotropnogo gormona na sekretsiiu al'dosterona u krys.