title: Tc-99m HMDP (hydroxymethylene diphosphonate): a radiopharmaceutical for skeletal and acute myocardial infarct imaging. I. Synthesis and distribution in animals.
abstract: Technetium-99m hydroxymethylene diphosphonate (Tc-99M HMDP) is a new diphosphonate skeletal imaging agent. Animal studies show that Tc-99m HMDP has a higher uptake on bone and a more rapid clearance from the blood than any of the three technetium-labeled bone imaging agents in current use: Tc-99m methylene diphosphonate (DMP), Tc-99 (1-hydroxyethylidene) diphosphonate (HEDP), and Tc-99m pyrophosphate (PPi). On the basis of these animal studies, Tc-99m HMDP is a highly promising candidate for skeletal imaging.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D011756:Diphosphates / Q000378:metabolism; D004164:Diphosphonates / Q000138:chemical synthesis / Q000378:metabolism; D004285:Dogs; D012968:Etidronic Acid / Q000378:metabolism; D006168:Guinea Pigs; D007275:Injections, Intravenous; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000378:metabolism; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives; D016698:Technetium Tc 99m Pyrophosphate; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D011756:Diphosphates; D004164:Diphosphonates; D015609:Organotechnetium Compounds; C019561:technetium Tc 99m etidronate; D016698:Technetium Tc 99m Pyrophosphate; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013667:Technetium; D012968:Etidronic Acid; D013669:Technetium Tc 99m Medronate