title: Collagen biosynthesis in healing wounds of the spinal cord and surrounding membranes.
abstract: Kinetics of collagen synthesis and deposition were studied in the canine spinal cord, pia mater, and dura mater and in wounds of these tissues over the first 8 weeks. Little collagen is present in unwounded spinal cord compared with surrounding mesenchymal membranes. Collagen synthetic potential was found within the spinal cord, a tissue of neurectodermal origin. Rate of collagen synthesis per collagen content in the unwounded spinal cord was high. This synthetic rate was as high as that of wounds at their maximum collagen synthetic rates. Substantial deposition of collagen followed spinal cord wounding. Wounding the spinal cord, pia mater, and dura mater caused substantial elevations in rates of collagen synthesis in each tissue. These synthetic rates remained at maximum levels throughout the 8-week study, a prolonged period when compared with other wounded tissues previously studied. The role of mesenchymal tissue physiology in central nervous system wound healing is discussed. The potential value of these findings for further studies and for experimental manipulation of the healing process in spinal cord and central nervous system wounds is presented. Implications of these findings on the hypothetical relationship of scar to spinal cord and central nervous system regeneration are noted.
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D004285:Dogs; D004388:Dura Mater / Q000201:enzymology / Q000378:metabolism; D010841:Pia Mater / Q000201:enzymology / Q000378:metabolism; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D013116:Spinal Cord / Q000201:enzymology / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000201:enzymology / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D003094:Collagen; D011393:Procollagen-Proline Dioxygenase