Effects of two different angiotensin II antagonists on aldosterone secretion by isolated perfused rat zona glomerulosa cells.
Isolated perfused rat zona glomerulosa cells have been used to determine the specificity of the angiotensin II antagonists, [Sar1,Ala8]angiotensin II and [Sar1,Ile8]angiotensin II. Both antagonists inhibited the aldosterone response to angiotensin II but did not affect serotonin- or potassium-induced aldosterone secretion. However, in contrast to [Sar1,Ala8]angiotensin II, [Sar1,Ile8]angiotensin II inhibited the aldosterone response to ACTH. These results suggest that there are differences in the specificity of these two analogs and that studies with [Sar1,Ile8]angiotensin II and its effect on aldosterone secretion should be interpreted with caution.
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology; D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D005260:Female; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012504:Saralasin / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
D000804:Angiotensin II; D012701:Serotonin; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D012504:Saralasin; D011188:Potassium