[Effect of veralipride on the estral cycle, genital tract, mammary gland and pituitary gland in female rats (author's transl)].
A study of the potential biological effects of veralipride was conducted in female rats. A definite stimulating action on the mammary gland was noted, but doses of 5 to 20 mg/kg/day are required to produce secretion, which is varying from one animal to another. Follicular maturation is preserved, though there is an increase in the number of corpora lutea with more marked development in some of them. Progesterone impregnation of the uterus occurs in a variable way and then only at doses of 5 + 0 20 mg/kg/day. Vaginal mucification, from a reduction in estrogen in relation to progesterone impregnation, is noted after 1 mg/kg/day (though 25 p. cent of the animals still demonstrate vaginal keratinization after 20 mg/kg/day). Finally, degranulation of the carminophile cells of the anterior pituitary gland, occurs after 5 mg/kg/day.
D000818:Animals; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005836:Genitalia, Female / Q000033:anatomy & histology / Q000187:drug effects*; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000378:metabolism; D010053:Ovary / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
D013469:Sulpiride; C027429:veralipride
Etude de l'action du véralipride sur le cycle oestral, le tractus génital, la glande mammaire et l'hypophyse de la ratte.