[Analysis of the excitable properties of an artificial membrane containing amphotericin B in the presence of cationic blockers].
A mathematical model was developed to describe the excitability of the amphotericin B--containing membrane with ionic blockers. The model is equivalent to the Hodgkin--Huxley model of the Na--channel with only one activating particle. A variety of the blockers parameters were evaluated with which the artificial membrane acquires excitable properties (generation of action potential, a self--oscillatory mode of pulse generation, trigger--like changes in the resting potential). The possibilities of constructing artificial excitable membranes with a cooperative activation of conductivity are discussed.
D000666:Amphotericin B; D007473:Ion Channels; D008433:Mathematics; D008564:Membrane Potentials; D008567:Membranes, Artificial; D008956:Models, Chemical; D012964:Sodium / Q000378:metabolism*
D007473:Ion Channels; D008567:Membranes, Artificial; D000666:Amphotericin B; D012964:Sodium
Analiz vozbudimykh svoĭstv iskusstvennoĭ membrany, soderzhashcheĭ amfoteritsin B, v prisutstvii kationnykh blokatorov.