Herpesvirus saimiri: protective effect of attenuated strain against lymphoma induction.
An attenuated strain of Herpesvirus saimiri (A-HVS) induced a persistent, latent infection in common marmosets. Virus was recovered from circulating lymphocytes of infected animals and antibody response to virus-specified antigens was demonstrated over 3-12 months PI. A-HVS-infected common marmosets and animals without previous A-HVS exposure were challenged with oncogenic HVS (125-825 PFU); marmosets without A-HVS infection developed malignant lymphoproliferative disease and died 3 weeks PI whereas all persistently-infected animals have survived 38-43 months post challenge.
D000818:Animals; D002143:Callitrichinae; D006566:Herpesviridae Infections / Q000276:immunology*; D006567:Herpesvirus 2, Saimiriine / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*