Comparisons of the effects of guanethidine, 6-hydroxydopamine and diethyldithiocarbamate on retention of passive avoidance.
Depending on the dose levels, guanethidine and diethyldithiocarbamate produced time dependent amnesia for a one-trial passive avoidance task. 6-Hydroxydopamine given at any dose level or at any time interval before or after training did not result in retention deficits. The results were discussed in terms of the effects of these agents on peripheral biogenic amines and the possible role of these amines in memory formation.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004050:Ditiocarb / Q000494:pharmacology*; D006145:Guanethidine / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D012153:Retention, Psychology / Q000187:drug effects*; D013859:Thiocarbamates / Q000494:pharmacology*
D006892:Hydroxydopamines; D013859:Thiocarbamates; D004050:Ditiocarb; D006145:Guanethidine