title: [A mathematical model for the study of the kinetics of serum alkaline phosphatase inhibition by sodium diethyldithiocarbamate (NaDDTC)].
abstract: A mathematical model for the kinetic of the serum alkaline phosphatase inhibition by NaDDTC is described in this paper. The model is tested over an experimental data set consisting on measured % residual activity of enzyme in human serum, after inhibition. The Bessey method is used. The solution of the differential equations for the model is found to be the best fitting for the observed time-dependent phenomena. The rate constant, K, for the inhibition reaction is then computed.
mesh_terms: D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000097:blood*; D004050:Ditiocarb / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008956:Models, Chemical; D013859:Thiocarbamates / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013859:Thiocarbamates; D004050:Ditiocarb; D000469:Alkaline Phosphatase
vernacular_title: Modello matematico per lo studio della cinetica di inibizione della fosfatasi alcalina sierica ad opera del dietilditiocarbammato di sodio (NaDDTC).