[Cyclic GMP-induced structural transitions of photoreceptor membranes].
The influence of cyclic GMP on the structural state of photoreceptor membranes was studied. The spin probe technique was used to obtain the dependences of microviscosity of lipid domains of membranes on cGMP concentration. It was shown that microviscosity of 5-doxylsteraric acid environment in rod outer segment, disc and plasma mambranes changed at concentrations of 2.10(7); 5.10(-6) and 6.10(-6). Non-cyclic GMP was ineffective. The ultrasound treatment of membraneous samples resulted on disappearance of the structural changes.
D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D006152:Cyclic GMP / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D008563:Membrane Lipids / Q000502:physiology; D010786:Photoreceptor Cells / Q000187:drug effects / Q000648:ultrastructure*; D012374:Rod Cell Outer Segment / Q000187:drug effects / Q000648:ultrastructure; D013113:Spin Labels
D008563:Membrane Lipids; D013113:Spin Labels; D006152:Cyclic GMP
Strukturnye perestroĭki fotoretseptornykh membran, indutsirovannye tsiklicheskim guanozinmonofosfatom.