[Pharmacological analysis of the cardiac stimulating action of mezaton].
In anesthetized dogs and rabbits, the increasing doses of mesaton raise the cardiac output and diminish overall peripheral vascular resistance. The cardiostimulant effect is prevented by obsidan, whilst the negative chronotropic by atropine. The effect of mesaton on alpha- and beta-adrenoreceptors is discussed.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002316:Cardiotonic Agents; D004285:Dogs; D004347:Drug Interactions; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D010656:Phenylephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D013566:Sympathomimetics / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013997:Time Factors
D002316:Cardiotonic Agents; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D013566:Sympathomimetics; D010656:Phenylephrine; D001285:Atropine; D011433:Propranolol
Farmakologicheskiĭ analiz kardiostimuliruiushchego deĭstviia mezatona.