Interaction of hormones with receptors and alterations of these processes with age.
A variety of hormone receptor concentrations appear to decrease during aging. Such reductions seem to be closely, if not causally, related to reduced responsiveness. The receptors appear to be lost from target cells during aging. The simple loss of target cells from target tissues is not a sufficient explanation for decreased hormone concentrations, since we can observe these changes in static cell populations. Currently, we are attempting to elucidate the molecular and neuroendocrine mechanisms that are involved in these changes, and we would like to apply some of the mechanisms of hormone receptor control to these problems of altered responsiveness.
D000273:Adipose Tissue / Q000378:metabolism; D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004822:Epididymis / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism
D011956:Receptors, Cell Surface; D011954:Receptors, Dopamine; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D005947:Glucose