Eaton-Lambert syndrome: a clinical and electrophysiological study of a patient treated with 4-aminopyridine.
In a patient with the Eaton-Lambert syndrome, 4-aminopyridine produced temporary improvement of clinical and electromyographic abnormalities. Application of the drug in vitro to intercostal muscle from the patient produced an increase in the evoked release of neurotransmitter from intramuscular nerves.
D000631:Aminopyridines / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000150:complications*; D004573:Electrolytes / Q000378:metabolism; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D007366:Intercostal Muscles / Q000294:innervation; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000188:drug therapy; D009469:Neuromuscular Junction / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*; D014459:Ulnar Nerve / Q000187:drug effects
D000631:Aminopyridines; D004573:Electrolytes