[Ionic mechanisms of the transmembrane current induced by injection of cyclic adenosine monophosphate into identified edible snail neurons].
The ionic mechanisms of transmembrane current evoked by cAMP injection (cAMP-current) into identified neurons of the snail were studied using the voltage clamp. cAMP-current was shown to consist of two components. The early component has a reversal potential in the region of -5 divided by +20 mV and the late one in the region of -55 divided by -60 mV. It is suggested that the early component of cAMP-current is associated with an increase in the neuron membrane permeability mainly for sodium ions and the late one for potassium ions, respectively. In LPa8 neuron AMP injection also evoked the transmembrane inward current which was independent of the holding potential and was not accompanied by changes in the membrane conductance.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D000242:Cyclic AMP / Q000494:pharmacology*; D004553:Electric Conductivity; D006372:Helix, Snails / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology
D012964:Sodium; D000242:Cyclic AMP; D011188:Potassium
Ionnye mekhanizmy transmembrannogo toka, vyzvannogo in"ektsieĭ tsiklicheskogo adenozinmonofosfata v identifitsirovannye neĭrony vinogradnoĭ ulitki.