title: Pattern of immunoreactive glucagon in portal, arterial and peripheral plasma before and after removal of glucagonoma.
abstract: Gel fractionation of portal, arterial and peripheral plasma glucagon levels was performed before and after the successful removal of a glucagonoma. A 47 year old woman had symptoms of dermatitis, weight loss, anemia and diabetes mellitus over a 16 year period. Removal of the alpha-cell tumor corrected all of her symptoms. Gel filtration of portal, arterial and peripheral blood showed two peaks of glucagon radioimmunoassay activity, a higher molecular weight glucagon with a molecular weight of 9,000 and a 3,500 dalton glucagon. Five minutes after tumor removal, the higher molecular weight glucagon had disappeared completely from the arterial and peripheral blood but not from the portal vein.
mesh_terms: D007516:Adenoma, Islet Cell / Q000276:immunology* / Q000601:surgery; D000941:Antigens; D005591:Chemical Fractionation; D002850:Chromatography, Gel; D005260:Female; D005934:Glucagon / Q000097:blood / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D008970:Molecular Weight; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000601:surgery; D011169:Portal Vein; D052336:Proglucagon; D011498:Protein Precursors / Q000097:blood; D011863:Radioimmunoassay
chemical_list: D000941:Antigens; D011498:Protein Precursors; D052336:Proglucagon; D005934:Glucagon