[Biochemical and pharmacological approach to the functional disorders observed in demyelination mutants (GABAergic and noradrenergic systems)].
The abnormal behavior observed in diseases of myelin remains unexplained. Mutations in the mouse in which the main phenotypic expression involves myelination is a useful tool. As tonic seizures are observed, an electrophysiological, pharmacological and biochemical study was performed. The convulsions seem to be linked mainly to an alteration of the alpha-adrenergic system. The GABA-ergic system is also modified. The relations between these observations and the defect of myelination remain to be elucidated.
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D003711:Demyelinating Diseases / Q000378:metabolism* / Q000503:physiopathology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008821:Mice, Quaking; D009638:Norepinephrine / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D015016:Yohimbine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D008565:Membrane Proteins; D011942:Receptors, Adrenergic, alpha; D017981:Receptors, Neurotransmitter; D015016:Yohimbine; D005680:gamma-Aminobutyric Acid; D009638:Norepinephrine
Approche biochimique et pharmacologique des troubles fonctionnels observés chez des mutants dysmyéliniques (systèmes GABAergiques et noradrénergiques).