Regional isolation-perfusion: an experimental percutaneous approach tested and compared with arterial occlusion-infusion.
A percutaneous approach was developed for the performance of regional isolation-perfusion, a surgical chemotherapeutic procedure for the intraarterial treatment of neoplasms. This technique was compared with percutaneous transcatheter arterial occlusion-infusion concerning local and systemic drug levels. Floxuridine (FUDR) was administered into a femoral artery of adult mongrel dogs, first by arterial occlusion-infusion, and 4 weeks later by regional isolation-perfusion of the opposite hind limb. Local and systemic plasma samples and local muscle specimens were collected for determination of FUDR levels. Results indicated not only that regional isolation-perfusion could be accomplished percutaneously, using balloon catheters, but also that the technique produced significantly greater local tissue FUDR levels (P less than 0.05) than those achieved with arterial occlusion-infusion.
D000800:Angioplasty, Balloon; D000818:Animals; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D004285:Dogs; D005263:Femoral Artery; D005467:Floxuridine / Q000008:administration & dosage*; D007261:Infusions, Intra-Arterial
D005467:Floxuridine