title: [Biosynthesis of polypeptide hormones].
abstract: The biosynthesis of numerous polypeptide hormones implicates two types of precursors: pre- and prohormones. The structure, characteristics, and role of these hormone precursors is discussed taking as examples parathyroid hormone and insulin. After this general introduction, the case of the common precursor for adrenocorticotropin and beta-lipotropin is then discussed. Its maturation proceeds through a serie of proteolytic steps which lead to the formation of various end products characterized each by a biological activity of its own.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004723:Endorphins / Q000096:biosynthesis; D006728:Hormones / Q000096:biosynthesis*; D007328:Insulin / Q000096:biosynthesis; D010281:Parathyroid Hormone / Q000096:biosynthesis; D010452:Peptide Biosynthesis; D011498:Protein Precursors / Q000378:metabolism; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000096:biosynthesis
chemical_list: D004723:Endorphins; D006728:Hormones; D007328:Insulin; D010281:Parathyroid Hormone; D011498:Protein Precursors; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin
vernacular_title: Biosynthese des hormones polypeptidiques.