Muscarinic-dopaminergic synergism on retinal cyclic AMP formation.
The cholinergic agonist, carbachol, produces a small increase in cyclic AMP concentration in the isolated rat retina, and markedly potentiates dopamine-stimulated cyclic AMP formation. This effect of carbachol is mediated through a muscarinic receptor, is calcium-independent, and is not due to inhibition of phosphodiesterase activity. Activation of muscarinic receptors may potentiate dopaminergic responses in the retina by enhancing coupling of the dopamine receptor to adenylate cyclase.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology*; D005260:Female; D010095:Oxotremorine / Q000494:pharmacology*; D051381:Rats; D011950:Receptors, Cholinergic / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology*; D012160:Retina / Q000187:drug effects / Q000378:metabolism*
D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D011976:Receptors, Muscarinic; D010095:Oxotremorine; D001285:Atropine; D002217:Carbachol; D000242:Cyclic AMP