Kainic acid stimulation of cerebellar cyclic GMP levels: potentiation by glutamate and related amino acids.
A number of excitatory amino acids (including kainate and other "excitotoxic" amino acids, (+/-)-ibotenate, and N-methyl-D-aspartate) are able to increase levels of cyclic GMP in cerebellar slices from immature (8-day-old) rats. The response to kainate is markedly potentiated by glutamate and a restricted number of analogues. This phenomenon is not seen with either (+/-)-ibotenate or N-methyl-D-aspartate, and may have implications for the possible mechanisms of cytotoxicity for kainate.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004357:Drug Synergism; D005971:Glutamates / Q000494:pharmacology*; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000596:Amino Acids; D005971:Glutamates; D011759:Pyrrolidines; D006152:Cyclic GMP; D007608:Kainic Acid