Cholecystokinin receptors in the brain: characterization and distribution.
Specific cholecystokinin binding sites in particulate fractions of rat brain were measured with iodine 125-labeled Bolton-Hunter cholecystokinin, a cholecystokinin analog that has full biological activity. Binding was detected in brain regions known to contain immunoreactive cholecystokinin. Binding was saturable, reversible, of high affinity (dissociation constant, 1.7 x 10(-9) M), and was inhibited by cholecystokinin analogs but not by unrelated hormones.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009830:Olfactory Bulb / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*
D005755:Gastrins; D011956:Receptors, Cell Surface; D002766:Cholecystokinin