[Membrane activity of canrenone in the normotensive subject: evaluation and significance].
Canrenone (100 mg per day) was given to ten young normotensive subjects during seven days. Plasma--K+ and erythrocytes--K+ (p less than 0,05), diuresis (+ 52%) and natriuresis (+ 70%) increased significantly during this time. Comparison between cations fluxes in erythrocytes before and after giving the drug showed an action on the membranal Na+ - K+ pump. This action site would complete well known anti-aldosterone properties.
D000328:Adult; D002192:Canrenone / Q000008:administration & dosage / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007473:Ion Channels / Q000187:drug effects*; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011245:Pregnadienes / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
D007473:Ion Channels; D000451:Mineralocorticoid Receptor Antagonists; D011245:Pregnadienes; D002192:Canrenone; D012964:Sodium; D011188:Potassium
L'activité membranaire de la canrénone chez le sujet normotendu : évaluation et signification.