DNA of avian myeloblastosis-associated virus type 2 integrates at multiple sites in the chicken genome.
The cellular sites of integration of the avian myeloblastosis-associated virus type 2 (MAV-2) DNA have been examined by Southern blot analysis of cellular DNA from infected cloned and uncloned chicken embryonic fibroblasts. Provirus-cell juncture fragments were not detected in restriction enzyme digests of DNA from MAV-2-infected uncloned cells. However, each MAV-2-infected cell clone examined produced a unique set of junctive bands. Thse findings indicate that multiple sites of integration exists for MAV-2 proviruses in cellular DNA.
D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D009189:Avian Myeloblastosis Virus / Q000235:genetics* / Q000254:growth & development; D001483:Base Sequence; D002642:Chick Embryo; D002999:Clone Cells; D004247:DNA; D004279:DNA, Viral / Q000235:genetics*; D005814:Genes, Viral; D011995:Recombination, Genetic; D012526:Satellite Viruses / Q000235:genetics* / Q000254:growth & development
D004279:DNA, Viral; D004247:DNA