Changes in collagen metabolism--another look at osteoarthrosis.
Collagen types I and III were isolated from osteoarthrotic cartilage. Immunofluorescence study has shown that these two collagen types are present in the deep layers of cartilage. Additional staining for fibronectin revealed the presence of the cell-adhesive protein in osteoarthrotic cartilage. Neither collagen type I and type III nor fibronectin were found in control cartilage. A passive haemagglutination assay determined anticollagen antibodies (against types I, II and III) in sera of some osteoarthrotic patients.
D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism* / Q000473:pathology
D003094:Collagen