title: Host-induced virus modification of murine hepatitis virus: changes in thermal stability.
abstract: Serial tissue culture passage of two cold-sensitive mutants of murine hepatitis virus altered the thermal stability of one mutant. This phenomenon occurred in only one of the continuous cell lines tested and was reversible by multiple passages in a cell line that does not alter thermal stability. The effect was cumulative with passage and was segregated from the cold-sensitive marker.
mesh_terms: D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D003080:Cold Temperature; D005814:Genes, Viral; D005819:Genetic Markers; D051379:Mice; D006517:Murine hepatitis virus / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D009154:Mutation; D014776:Virus Cultivation
chemical_list: D005819:Genetic Markers