Amyloid neuropathy and tremor in Waldenström's macroglobulinemia.
We report a case of Waldenström's macroglobulinemia with amyloid neuropathy and a parkinsonian syndrome. We describe the light and electron microscopic findings in a sural nerve biopsy specimen and discuss the possible pathogenic mechanisms in the production of the neuropathy. In contrast to a number of previous cases of neuropathy associated with Waldenström's macroglobulinemia, evidence of immunoglobulin deposition on nerve fibers was not found using immunofluorescent techniques.
D000686:Amyloidosis / Q000473:pathology*; D001706:Biopsy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009443:Neuritis / Q000473:pathology*; D009454:Neurofibrils / Q000648:ultrastructure; D010300:Parkinson Disease / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000473:pathology; D013127:Spinal Nerves / Q000473:pathology*; D013497:Sural Nerve / Q000473:pathology*; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology*