Combined effect of the extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells.
The combined usage of n-butyrate and 12-O-tetradecanoylphorbol-13-acetate (TPA) or the oily extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli exerted a marked effect on induction of Epstein-Barr virus (EBV)-associated early (EA) and viral capsid (VCA) antigens in EBV genome-carrying human lymphoblastoid cell lines. In producer P3HR-1 cells, the enhancing effect of the 2 components was additive both for EA and VCA, while in non-producer Raji cells, a synergistic increase of EA was observed. The possible implication of these findings relating to the cause of EBV-associated diseases is discussed.
D000956:Antigens, Viral; D002213:Capsid / Q000276:immunology; D002478:Cells, Cultured; D003436:Croton Oil / Q000494:pharmacology*; D004347:Drug Interactions; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D010704:Phorbols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014775:Virus Activation
D000956:Antigens, Viral; D010704:Phorbols; D010936:Plant Extracts; D003436:Croton Oil; D013755:Tetradecanoylphorbol Acetate