title: [Evolution of the regional blood deficit and energy metabolism after induction of transient cerebral ischemia by occlusion of the vertebral and carotid arteries in the rat].
abstract: A transient brain ischemia of 10 min duration was produced in rats by electrocautery of the vertebral arteries and reversible occlusion of the carotid arteries. Ischemia reduced blood flow to 10-18% of the control values in forebrain structures (cortex, striatum, thalamus) and to 25-50% in the mesencephalon, cerebellum and brain stem. In these last structures, after 30 min of recirculation, the flow rates returned to normal values but a 20-35% reduction of blood flow was present in the forebrain structures, indicating that the development of the postischemic hypoperfusion was related to the severity of the preceding ischemia. After 30 min of recirculation, there was a near complete recovery of the high energy compounds but a residual metabolic dysfunction was evidenced by an increase in lactate/pyruvate ratio and an elevation of the glucose content, suggesting a depression of cerebral metabolism which may account for the brain hypoperfusion.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002339:Carotid Arteries / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D004734:Energy Metabolism; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014711:Vertebral Artery / Q000503:physiopathology
vernacular_title: Evolution du débit sanguin régional et du métabolisme énergétique après induction d'une ischémie cérébrale transitoire réalisée chez le rat par occlusion des artères vertébrales et carotides.