Is type 1b glycogenosis related to an anomeric preference for glucose-6-phosphate uptake by hepatic microsomes?
The contradictory data obtained in studies of type 1b glycogenosis would be explained by an anomeric preference for the capture of glucose-6-phosphate by hepatic microsomes. The alpha anomers of hexoses would be utilized preferentially by glycogenolysis and gluconeogenesis, while the beta anomers of hexoses would be preferentially utilized for glycolysis.
D005943:Gluconeogenesis; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005958:Glucosephosphates / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D005953:Glycogen Storage Disease Type I / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism*; D008954:Models, Biological; D010539:Permeability; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D005958:Glucosephosphates; D006003:Glycogen; D005952:Glucose-6-Phosphatase