The extrusion of sodium ions from presynaptic nerve endings of rat cerebral cortex.
(Na+-K+) ATPase is present in synaptosomal preparations and it is assumed to represent the sodium-potassium pump. 10 microM-noradrenaline activates (Na+-K+) ATPase approximately 100%, but 50 microM-noradrenaline does not stimulate the rate of 22Na extrusion from synaptosomes. The results suggest that it is unlikely that the noradrenaline stimulation of (Na+-K+) ATPase is part of a feedback mechanism whereby released noradrenaline can influence the activity of the presynaptic sodium pump.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002414:Cations, Monovalent; D002540:Cerebral Cortex / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism*
D002414:Cations, Monovalent; D000255:Adenosine Triphosphate; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine