Double tumors of anterior and posterior pituitary gland.
Double tumors were found in the anterior and posterior lobes of pituitary gland at autopsy in a patient who presented with progressive deterioration of mental status. The chromophobe adenoma of anterior lobe consisted of a mixture of non-immunoreactive hormone containing cells and a few prolactin (PRL) and growth hormone (GH) cells in the mid portion whereas the periphery of the tumor contained immunoreactive cells for PRL, GH, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). A microscopic focus of granular cell myoblastoma (GCM) was found in the posterior lobe. Differentiation of tumor cells into anterior pituitary cells and GCM is discussed.
D000238:Adenoma, Chromophobe / Q000032:analysis / Q000473:pathology; D000368:Aged; D001344:Autopsy; D005640:Follicle Stimulating Hormone / Q000032:analysis; D013006:Growth Hormone / Q000032:analysis; D006801:Humans; D007986:Luteinizing Hormone / Q000032:analysis; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009379:Neoplasms, Muscle Tissue / Q000473:pathology; D010903:Pituitary Gland, Anterior / Q000473:pathology*; D010904:Pituitary Gland, Posterior / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000032:analysis / Q000473:pathology*; D011388:Prolactin / Q000032:analysis; D013972:Thyrotropin / Q000032:analysis
D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone