Hemoglobin Hammersmith (beta 42 (CD1) Phe replaced by Ser) associated with severe hemolytic anemia.
Hemoglobin Hammersmith was detected in a five year old white female suffering from severe anemia first noted at 18 months of age. She has been splenectomized and her peripheral blood red cells were found to contain inclusion bodies.
D000596:Amino Acids / Q000032:analysis; D000743:Anemia, Hemolytic / Q000097:blood*; D002675:Child, Preschool; D004912:Erythrocytes / Q000166:cytology / Q000201:enzymology; D005260:Female; D005914:Globins; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D002479:Inclusion Bodies; D009154:Mutation; D010446:Peptide Fragments; D013156:Splenectomy
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D010446:Peptide Fragments; C011478:hemoglobin Hammersmith; D005914:Globins