title: Studies on osteoporosis III. Effect of estrogens and fluoride.
abstract: Total skeletal calcium levels were determined in female mice with the aid of whole body neutron activation analysis. Three months treatment with heparin produced significant osteoporosis in C3-H/St(Ha) mice but not in C57/BL6 (J) mice. Treatment with a conjugated natural estrogen preparation (Premarin) prevented heparin accelerated osteoporosis, but high level fluoride in the drinking water had no preventive effect. In some experiments there was a suggestion of a deleterious effect of fluoride.
mesh_terms: D000818:Animals; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D005457:Fluoridation; D006493:Heparin; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D004966:Estrogens, Conjugated (USP); D006493:Heparin