[Peroxidase and human thyroid hormone synthesis disorders (author's transl)].
Thyroid peroxidase in involved in several steps of the biosynthesis of thyroid hormone utilizing H2O2: peroxidation of iodide to iodine, iodination of thyroglobulin (Tg) and coupling reaction leading to T4 and T3 formation. The peroxidase enzyme appears to be an heme protein containing a protoporphyrin IX, with binding sites for both iodide and tyrosine. Although the peroxidase is present in numerous cellular structure, iodination activity occurs primarily if not only at all, at the apical cell border. Lack of peroxidase activity or abnormal peroxidase has been described in isolated cases of congenital goiter with organification defect and a positive perchlorate test. However no change in enzymatic activity has been found in patients with Pendred's syndrome as compared to normal tissue. The deficiency of hormone synthesis observed in various benign diffuse thyroid disorders in certainly not due to a lack of peroxidase activity. In treated hyperthyroid patients, a high cellular activity is observed, especially at the apical cell border. In euthyroid patients with diffuse sporadic goiter, an increase of peroxidase activity is also observed. However, the cytochemical localization of the enzyme in goitrous thyroid gland shows that the peroxidase activity is mostly visualized around numerous lipoid structures; being concentrated in this particular site, the enzyme might preferentially oxidize lipids and consequently be less available for hormone synthesis. In euthyroid hot nodule, the peroxidase activity is normal. In cold nodule, a discrepancy between iodide oxidation and protein iodination has been found, suggesting that iodide peroxidation and iodination of tyrosine residues of Tg are two relatively independent processes although thyroid peroxidase catalyses both reactions. In contrast with the benign pathological conditions, the peroxidase activity is lower than normal in thyroid cancerous tissue.
D006801:Humans; D007453:Iodide Peroxidase / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*; D013959:Thyroid Diseases / Q000151:congenital / Q000503:physiopathology; D013963:Thyroid Hormones / Q000096:biosynthesis*; D013964:Thyroid Neoplasms / Q000503:physiopathology; D013972:Thyrotropin / Q000502:physiology
D013963:Thyroid Hormones; D013972:Thyrotropin; D010544:Peroxidases; D007453:Iodide Peroxidase
[Rôle de la peroxydase dans les troubles de l'hormonosynthèse thyroïdienne chez l'homme.