Ubiquinones have surface-active properties suited to transport electrons and protons across membranes.
Surface-active properties of ubiquinones and ubiquinols have been investigated by monomolecular-film techniques. Stable monolayers are formed at an air/water interface by the fully oxidized and reduced forms of the coenzyme; collapse pressures and hence stability of the films tend to increase with decreasing length of the isoprenoid side chain and films of the reduced coenzymes are more stable than those of their oxidized counterparts. Ubiquinone with a side chain of two isoprenoid units does not form stable monolayers at the air/water interface. Mixed monolayers of ubiquinol-10 or ubiquinone-10 with 1,2-dimyristoyl phosphatidylcholine, soya phosphatidylcholine and diphosphatidylglycerol do not exhibit ideal mixing characteristics. At surface pressures less than the collapse pressure of pure ubiquinone-10 monolayers (approx. 12mN.m(-1)) the isoprenoid chain is located substantially within the region occupied by the fatty acyl residues of the phospholipids. With increasing surface pressure the ubiquinones and their fully reduced equivalents are progressively squeezed out from between the phospholipid molecules until, at a pressure of about 35mN.m(-1), the film has surface properties consistent with that of the pure phospholipid monolayer. This suggests that the ubiquinone(ol) forms a separate phase overlying the phospholipid monolayer. The implications of this energetically poised situation, where the quinone(ol) is just able to penetrate the phospholipid film, are considered in terms of the function of ubiquinone(ol) as electron and proton carriers of energy-transducing membranes.
D001692:Biological Transport; D004134:Dimyristoylphosphatidylcholine; D004579:Electron Transport; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D010743:Phospholipids; D011312:Pressure; D011522:Protons; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014451:Ubiquinone
D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D010743:Phospholipids; D011522:Protons; D014451:Ubiquinone; D004134:Dimyristoylphosphatidylcholine