The inhibition by (+/-)-propranolol of the positive inotropic effects of (+/-)-isoprenaline and (-)-noradrenaline. Competitive antagonism and saturable uptake.
D000818:Animals; D001667:Binding, Competitive; D003042:Cocaine / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007545:Isoproterenol / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008297:Male; D008433:Mathematics; D008962:Models, Theoretical; D009200:Myocardial Contraction / Q000187:drug effects*; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011433:Propranolol / Q000378:metabolism / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013237:Stereoisomerism; D013268:Stimulation, Chemical
D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D003042:Cocaine; D007545:Isoproterenol; D009638:Norepinephrine