title: [Adrenal cortex function in trophoblastic disease].
abstract: In 100 patients with trophoblastic tumors the functional activity of the adrenal cortex was examined before and after chemotherapy. Androgen-producing function of the adrenal cortex was found to be reduced as well as the absolute number of excreted 17-ketosteroids separate fractions and their ratio. The glucocorticoid function of the adrenal cortex shows a monotonous character. Only in patients having uterine chorion-epithelioma with metastases a reliable reduction of the fraction of 11-hydroxy-17-ketosteroids is noted before and after chemotherapy, while the per cent content of free 17-oxy-corticoid fraction is increased with regard to their total amount. Successful chemotherapy, associated with a lower titre of chorionic gonadotropins up to its complete disappearance, does not result in normalization of values characterizing the functional activity of the adrenal cortex.
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000652:urine; D015068:17-Ketosteroids / Q000652:urine; D000293:Adolescent; D000302:Adrenal Cortex / Q000503:physiopathology*; D000328:Adult; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000503:physiopathology*; D014594:Uterine Neoplasms / Q000503:physiopathology*
chemical_list: D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids
vernacular_title: Funktsional'noe sostoianie kory nadpochechnikov pri trofoblasticheskoĭ bolezni.