Effect of short-chain fatty acids on Epstein-Barr virus early and viral capsid antigen induction in P3HR-1 cells.
The effects of short-chain fatty acids were assayed for their capacity to induce Epstein-Barr virus (EBV) from the EBV genome-carrying human lymphoblastoid P3HR-1 cells. Not only the n-butyric acid, the activity of which is now well established, but also the n-valeric acid was found to induce EBV-associated early antigen (EA) and viral capsid antigen (VCA) at an appreciable level. Similarly, i-valeric acid showed a considerably lower, but significant, level of this activity, while the i-butyric acid was inactive. All other fatty acids with either a chain shorter than butyric or longer than valeric showed only a marginal effect or none at all. Thus, the decisive factor for EBV-inducing capacity of the fatty acids concerns adequate length and configuration of the basic structure of the molecules.
D000956:Antigens, Viral / Q000032:analysis*; D002087:Butyrates / Q000494:pharmacology; D002213:Capsid / Q000276:immunology; D002460:Cell Line; D005232:Fatty Acids, Volatile / Q000494:pharmacology*; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000254:growth & development*; D006801:Humans; D014775:Virus Activation / Q000187:drug effects*
D000956:Antigens, Viral; D002087:Butyrates; D005232:Fatty Acids, Volatile