Effects of cerebral gangliosides in the alcoholic polyneuropathies.
In chronic alcoholic patients with a slight or moderate polyneuropathy the effect of gangliosides at a daily dosage of 20 mg was investigated. A clinical improvement represented by a reappearance of the Achilles reflex and/or marked reduction of hypoaesthesia was found in the treated group. No significant changes in motor function were observed. No significant variation of the electrophysiological examination was found.
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D000437:Alcoholism / Q000150:complications*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005732:Gangliosides / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors
D005732:Gangliosides