Intracellular levels of adenosine 3':5'-cyclic monophosphate in the dorsal iris of the adult newt, during lens regeneration.
The intracellular levels of adenosine 3':5'-cyclic monophosphate (cAMP) were measured in the dorsal iris of the adult newt, during the first 20 days of lens regeneration. It was found that by day 2 after lens removal there is a significant drop in the levels of cAMP. After day 2 the levels of the nucleotide increase and by day 3 they are higher than those detected on day 0. The levels of cAMP remain high up to day 8. From day 8 to day 9 there is a second drop. From day 9 to day 20 the levels of cAMP did not differ significantly from the value obtained for day 0, except for days 10, 12, and 15. The period of high levels of cAMP coincides with the period of depigmentation of iris epithelial cells, the key event of lens regeneration.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D007498:Iris / Q000378:metabolism*; D007908:Lens, Crystalline / Q000378:metabolism / Q000502:physiology*; D012038:Regeneration; D012455:Salamandridae / Q000502:physiology; D013997:Time Factors
D000242:Cyclic AMP