A position-effect control for gene transposition: state of expression of yeast mating-type genes affects their ability to switch.
Mating-type switches of the yeast Saccharomyces cerevisiae occur by unidirectional transposition of copies of unexpressed mating-type genetic information, residing at HML and HMR loci, into the expressed MAT locus. The HML and HMR loci remain unchanged. In contrast, in appropriate strains where the silent loci are also allowed to express, for example in mar mutants, efficient switches of HML and HMR are shown to occur at rates equivalent to those observed for MAT. Thus the position-effect control on the direction of transposition is affected by the state of expression of the locus under study the expressed loci switch regardless of their location.
D003433:Crosses, Genetic; D004262:DNA Restriction Enzymes; D004271:DNA, Fungal; D005786:Gene Expression Regulation; D009154:Mutation; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology
D004271:DNA, Fungal; D004262:DNA Restriction Enzymes