A role of guanosine 3',5'-monophosphate in human-prolactin-induced estrogen production by feminizing adrenal neoplastic cells.
Using feminizing adrenal neoplastic gland (FANG) cells we showed that hPRL stimulated cGMP biosynthesis. Also we could clearly demonstrate a stimulatory effect of db-cGMP plus theophylline on estrogen production without concomitant stimulation of cell growth. These findings indicate that a stimulatory effect of hPRL on estrogen biosynthesis by Fang-8 cells may act via increased cGMP concomitant with depressed cAMP.
D000310:Adrenal Gland Neoplasms / Q000378:metabolism; D002460:Cell Line; D000242:Cyclic AMP / Q000096:biosynthesis; D006152:Cyclic GMP / Q000096:biosynthesis*; D004967:Estrogens / Q000096:biosynthesis*; D006729:Hormones, Ectopic / Q000096:biosynthesis; D006801:Humans; D011388:Prolactin / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology
D004967:Estrogens; D006729:Hormones, Ectopic; D011388:Prolactin; D013806:Theophylline; D000242:Cyclic AMP; D006152:Cyclic GMP