Influence of haloperidol on ACTH and beta-endorphin secretion in the rat.
The injection of haloperidol, a dopamine receptor blocker, was followed by a large increase of plasma ACTH and beta-endorphin-like immunoreactivity (beta-EI) in the rat. This effect was prevented when the rats were previously treated with corticosteroids. These results suggest that catecholamines inhibit ACTH and beta-endorphin secretion in the rat.
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004723:Endorphins / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical
D004723:Endorphins; D000324:Adrenocorticotropic Hormone; D006220:Haloperidol