Effects of methysergide and naloxone on analgesia induced by the peripheral electric stimulation in mice.
We investigated the antinociceptive effects produced by peripheral electric stimulation (PES) in mice and the influence of administration of L-5-hydroxytryptophan (5-HTP), methysergide and naloxone on the antinociceptive effect of the PES. Administration of 5-HTP enhanced antinociceptive effects induced by PES, while methysergide and naloxone abolished this antinociception. The mechanisms of analgesia produced by PES involve both endogenous opiate systems and central serotonergic mechanisms.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects; D004558:Electric Stimulation; D008297:Male; D008784:Methysergide / Q000494:pharmacology*; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects*; D010525:Peripheral Nerves / Q000187:drug effects*; D011957:Receptors, Opioid / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism
D011957:Receptors, Opioid; D011985:Receptors, Serotonin; D012701:Serotonin; D009270:Naloxone; D006916:5-Hydroxytryptophan; D008784:Methysergide