[Inhibition of chloride permeability and sodium transport in frog skin by mercusal and ethacrynic acid].
Potential difference across the frog skin is increased 1-2 min after addition of 0.063-1.0 mg/ml ethacrynic acid or 0.2-1.0 mg/ml mercusal to outside Ringer solution. Within this time the short-circuit current remains unchanged or increased. Potential difference and short-circuit current are diminished after the addition of ethacrynic acid or mercusal to inside solution. This effect is similar to that of ouabain. These findings suggest that ethacrynic acid and mercusal inhibit chloride channel in the apical cell membrane, and inhibit sodium transport in the basolateral membrane.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002712:Chlorides / Q000378:metabolism*; D004976:Ethacrynic Acid / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects*; D008634:Mersalyl / Q000494:pharmacology*; D009941:Organomercury Compounds / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology; D011895:Rana ridibunda; D011896:Rana temporaria; D012867:Skin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D002712:Chlorides; D007473:Ion Channels; D009941:Organomercury Compounds; D010042:Ouabain; D008634:Mersalyl; D005665:Furosemide; D012964:Sodium; D004976:Ethacrynic Acid
Ugnetenie merkuzalom i étakrinovoĭ kislotoĭ khlornoĭ pronitsaemosti i transporta natriia v kozhe liagushkhi.