Captopril and the maintenance of blood pressure after sinoaortic denervation in the rabbit.
1. At a dose of 1 mg/kg intravenously, captopril lowered blood pressure in conscious rabbits, that had undergone denervation of sinoaortic baroreceptors, but had no effect on heart rate. In sham-operated controls, this dose caused only an increase in heart rate. 2. In the same experiments, captopril caused a substantial inhibition of plasma angiotensin converting enzyme (CE) activity of rapid onset and gradual decline over 2 to 3 h. The time course of recovery of blood pressure and plasma CE activity were similar. 3. Saralasin, by intravenous infusion, lowered blood pressure in sinoaortic rabbits but to a smaller extent than captopril. 4. The fall in blood pressure observed after captopril is not dependent on the integrity of baroreceptor afferents.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001013:Aorta, Thoracic / Q000294:innervation*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D002346:Carotid Sinus / Q000294:innervation*; D003714:Denervation; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011311:Pressoreceptors / Q000502:physiology; D011392:Proline / Q000031:analogs & derivatives*; D011817:Rabbits; D012504:Saralasin / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D011392:Proline; D002216:Captopril; D012504:Saralasin