[Possible role of sympathetic influences and cAMP in centrifugal inhibitory control of the gustatory receptor apparatus].
The electrophysiological analysis of the taste total impulse activity of the rat revealed the inhibitory influence of the gastric distention on the salt and sour taste responses to be decreased by cutting of the neck sympathetic nerve and prevented by the propranolol injection into the taste epithelium. Salt and sour taste responses were diminished by the injection of isoproterenol, cAMP, dibutyril--cAMP, and the inhibitors fo phosphodiesterase theophilline and paraverine; the activator of phosphodiesterase nicotine acid increased the taste responses. The finding suggest that the adrenergic transmitters and cAMP take part in the actualization of the inhibitory centrifugal influences.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology; D008465:Mechanoreceptors / Q000502:physiology; D009539:Nicotinic Acids / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013270:Stomach / Q000294:innervation; D013564:Sympathetic Nervous System / Q000502:physiology*; D013649:Taste / Q000187:drug effects / Q000502:physiology*; D013806:Theophylline / Q000494:pharmacology
D009539:Nicotinic Acids; D003994:Bucladesine; D011433:Propranolol; D013806:Theophylline; D010208:Papaverine; D000242:Cyclic AMP; D007545:Isoproterenol
O vozmozhnoĭ roli simpaticheskikh vliianiĭ i tsAMF v tsentrobezhnom tormoznom kontrole vkusovogo retseptornogo apparata.