Increased aldosterone secretion induced by sulpiride.
Sulpiride induces an increase in plasma prolactin and a simultaneous increase of aldosterone release in man. In isolated and superfused bovine adrenal glands, prolactin does not increase aldosterone production even in high concentrations, whereas sulpiride induces a significant and long lasting increase in the production of this hormone and a concomitant increase in the tissue levels of cAMP. This suggests a direct effect on the biosynthesis of aldosterone.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis; D066298:In Vitro Techniques; D011388:Prolactin / Q000097:blood / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology*
D000450:Aldosterone; D013469:Sulpiride; D011388:Prolactin; D000242:Cyclic AMP; D006854:Hydrocortisone