Detectability of radiation damage to melanoma cells using ESR spectroscopy. A review.
Comparison of indirect and direct methods applicable for the examination of radiation damage to melanoma cells leads to the conclusion that the only method useful for its detection appears to be the indirect method. The paper describes the principle, examples of radiobiological applications, and perspectives of future development of a new indirect method of measuring oxygen consumption by neoplastic cells under in vitro conditions. The method is based on the use of a spin label technique.
D002478:Cells, Cultured; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D066298:In Vitro Techniques; D008543:Melanins / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism* / Q000648:ultrastructure; D008928:Mitochondria / Q000378:metabolism / Q000528:radiation effects*; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000648:ultrastructure; D010101:Oxygen Consumption / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000648:ultrastructure
D005609:Free Radicals; D008543:Melanins