Efficacy of a nucleic acid free herpetic subunit vaccine.
The efficacy of immunization with an herpes simplex subunit vaccine, free of nucleic acid, was evaluated in mice, rabbits and monkeys. One injection of 3 micrograms per kg of body weight elicited both humoral and cell-mediated immunity in all the animals studied. Furthermore, the immunization reduced significantly the mortality to a subsequent challenge with live herpes simplex virus in mice and rabbits (p less than 0.01).
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D006023:Glycoproteins / Q000276:immunology; D006561:Herpes Simplex / Q000517:prevention & control*; D007114:Immunization; D007117:Immunization, Secondary; D008213:Lymphocyte Activation; D051379:Mice; D002679:Pan troglodytes; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D006023:Glycoproteins; D014764:Viral Proteins; D014765:Viral Vaccines