Effect of histamine on the spontaneous E rosette formation after blockade of histamine H2 receptors with cimetidine.
Thirteen patients with clinical diagnosis of hay fever, were examined. T lymphocytes subpopulation was determined by the E rosette test. The present study is concerned with the effect of histamine on the ability of T lymphocytes for E rosette formation after blockade of the histamine H2 receptor with its inhibitor cimetidine. It has been found that histamine effect is expressed by the histamine H2 receptor, as its blockade with cimetidine leads to the failure of histamine to inhibit rosette formation by T lymphocytes.
D000293:Adolescent; D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000502:physiology; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D006146:Guanidines; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D002927:Cimetidine; D006632:Histamine; D000242:Cyclic AMP