In vitro activity of mecillinam against anaerobic bacteria.
A microtiter broth dilution method was employed to determine the in vitro activity of mecillinam against 201 recent clinical isolates of anaerobic bacteria. Both the anaerobic gram-positive and anaerobic gram-negative bacilli displayed a wide range of minimal inhibitory concentrations of mecillinam; most strains were resistant to the antibiotic. The anaerobic cocci exhibited a narrower range of minimal inhibitory concentrations than were observed with other anaerobes, but also exhibited mecillinam resistance. As a single drug, mecillinam does not appear to be an effective antimicrobial agent against anaerobic bacteria.
D000560:Amdinocillin / Q000378:metabolism / Q000494:pharmacology*; D000693:Anaerobiosis; D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000494:pharmacology*
D003470:Culture Media; D010397:Penicillanic Acid; D000560:Amdinocillin