Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogues.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000138:chemical synthesis*; D001921:Brain / Q000378:metabolism; D003984:Dibenzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D007099:Imipramine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008958:Models, Molecular; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000378:metabolism
D000929:Antidepressive Agents, Tricyclic; D003984:Dibenzazepines; D009287:Naphthyridines; D011942:Receptors, Adrenergic, alpha; D011954:Receptors, Dopamine; D011976:Receptors, Muscarinic; D012701:Serotonin; D007099:Imipramine; D009638:Norepinephrine