Effect of paraquat on serum angiotensin converting enzyme.
Intraperitoneal administration of paraquat to mice produced a linear dose-response increase (20 to 50 mg/kg of body weight) in serum angiotensin converting enzyme (ACE). The peak increase (31%) in ACE occurred after 50 mg/kg of paraquat and began at approximately 4 h. ACE was still significantly elevated 8 h after the administration of paraquat, but it began to return to normal 24 h later. Although serum ACE increased during the first 5 h after the administration of paraquat, lung ACE decreased. The enzyme that we measured in mouse serum was inhibited 100% by 10(-7) M of SQ 20881, a known ACE inhibitor.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008168:Lung / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D010269:Paraquat / Q000494:pharmacology*; D007703:Peptidyl-Dipeptidase A / Q000097:blood* / Q000378:metabolism; D013997:Time Factors
D007703:Peptidyl-Dipeptidase A; D010269:Paraquat