title: Calcium: the managing director. The regulatory role and the regulation of calcium fluxes in living cells.
abstract: Calcium ions exert important controlling influences in various compartments of living cells; fluxes across the membrane barriers around and within cells are thus highly regulated. Ca2+-binding proteins such as calmodulin act as transducers and affect a large variety of processes in rapidly reversible ways. Adrenergic mechanisms in the heart and in smooth muscle illustrate these concepts.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism; D009200:Myocardial Contraction
chemical_list: D002147:Calmodulin; D000242:Cyclic AMP; D002118:Calcium