Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant.
S-2 (3-aminopropylamino)ethylphosphorothioate ameliorates hearing losses due to ototoxic doses of kanamycin sulfate in the guinea pig when administered one hour before the antibiotic. Since this radioprotectant is believed to operate as a free-radical scavenger, kanamycin ototoxicity may involve free radicals.
D004999:Amifostine / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D006168:Guinea Pigs; D006309:Hearing / Q000187:drug effects; D006311:Hearing Disorders / Q000139:chemically induced / Q000517:prevention & control*; D007612:Kanamycin / Q000009:adverse effects*; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D012022:Reflex, Acoustic / Q000187:drug effects
D009946:Organothiophosphorus Compounds; D007612:Kanamycin; D004999:Amifostine