Inhibitory actions of amino acids in the preoptic-anterior hypothalamus of the rat.
Extracellular recordings were made from preoptic-anterior hypothalamic neurones with combined recording and iontophoresis electrodes. Short iontophoretic applications of beta-alanine, GABA, glycine and taurine inhibited the discharge of the majority of neurones tested. Bicuculline metho-chloride reversibly and selectively antagonised GABA responses. Strychnine reversibly antagonised beta-alanine, glycine and taurine but not GABA responses. These results suggest the existence of two populations of inhibitory amino acid receptors in the preoptic-anterior hypothalamus. The function of inhibitory amino acids in the rostral hypothalamus was briefly discussed.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005998:Glycine / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects*; D007032:Hypothalamus, Anterior / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D011301:Preoptic Area / Q000187:drug effects*; D051381:Rats; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D013654:Taurine / Q000494:pharmacology; D015091:beta-Alanine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000596:Amino Acids; D015091:beta-Alanine; D013654:Taurine; D005680:gamma-Aminobutyric Acid; D013331:Strychnine; C006749:bicuculline methochloride; D005998:Glycine; D001640:Bicuculline