Involvement of adrenergic receptors in skeletal muscle metabolism of the cold-adapted rat.
Hind-limb perfusion was used to investigate alterations of alpha and beta receptor-mediated metabolic effects in cold-adapted (CA) rats. The response to beta receptor stimulation by isoproterenol in the isolated hind-limbs of CA rats was slightly diminished. Oxygen consumption and lactate production were reduced in CA rats after beta receptor stimulation. Noradrenalin infusion caused less vasoconstriction in CA rats than in the controls (CO). Desensitization of alpha and beta receptors due to chronic sympathetic overstimulation may be the underlying cause of these observations. Compared with the controls, metabolism was enhanced in perfused hind-limbs of CA rats with an active nervous system. Decreased vascular resistance due to the lower perfusion pressure in CA rats might contribute to this increased metabolism.
D000222:Adaptation, Physiological; D000409:Alanine / Q000096:biosynthesis; D000818:Animals; D003080:Cold Temperature; D003714:Denervation; D006614:Hindlimb / Q000378:metabolism; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D007773:Lactates / Q000096:biosynthesis; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption; D010477:Perfusion; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D007773:Lactates; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D007545:Isoproterenol; D000409:Alanine; D009638:Norepinephrine