Correlation between terbutaline serum levels, c-AMP plasma levels and FEV1 in normals and asthmatics after subcutaneous administration.
Terbutaline serum levels, c-AMP plasma levels and percentage improvement in FEV1, were strongly correlated after subcutaneous administration of terbutaline to normals (n = 6) and to asthmatics (n = 5). Changes in c-AMP plasma levels were similar in both normals and asthmatics after subcutaneous administration, denying a systemically beta-adrenergic defect to be present in asthmatics.
D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D000242:Cyclic AMP / Q000097:blood*; D005541:Forced Expiratory Volume; D006801:Humans; D007279:Injections, Subcutaneous; D007700:Kinetics; D008875:Middle Aged; D012129:Respiratory Function Tests; D013726:Terbutaline / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism
D000242:Cyclic AMP; D013726:Terbutaline