Pharmacology of guanfacine.
1. The pharmacological effects of the centrally acting antihypertensive drug guanfacine are reviewed. 2. The drug lowers systemic blood pressure in hypertensive rats dose-dependently after oral application of 0.3-5 mg/kg. 3. Evidence is presented that guanfacine produces its antihypertensive action by a specific stimulation of central alpha-adrenoceptors. 4. Certain pharmacological differences between clonidine and guanfacine are discussed.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003000:Clonidine / Q000494:pharmacology; D004285:Dogs; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016316:Guanfacine; D006146:Guanidines / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D010648:Phenylacetates / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects
D000959:Antihypertensive Agents; D006146:Guanidines; D006993:Hypnotics and Sedatives; D010648:Phenylacetates; D011942:Receptors, Adrenergic, alpha; D016316:Guanfacine; D003000:Clonidine; D004298:Dopamine