Immunohistochemical demonstration of common antigen of polyomaviruses in routine histologic tissue sections of animals and man.
All polyomaviruses have a common antigen, which is located on the major capsid polypeptide (VPI). This antigen was demonstrated in routine histologic sections of formalin-fixed paraffin-embedded tissues by the peroxidase-antiperoxidase technic. Antiserum to the common determinant reacted with JC virus in oligodendrocytes of a patient who had progressive multifocal leukoencephalopathy, BK virus in bladder epithelium of a renal transplant patient, and K virus in endothelial cells of mouse lung. This method may be applicable to the screening of tissues for all polyomaviruses in diagnostic and investigative pathology.
D000328:Adult; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D001739:BK Virus / Q000276:immunology; D002213:Capsid / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011120:Polyomavirus / Q000276:immunology*; D014412:Tumor Virus Infections / Q000175:diagnosis
D000956:Antigens, Viral