Resistance of cultures of normal T cells to infection with murine type C viruses.
Long-term continuous cultures of normal T cells were established from C57BL/6 and BALB/c mice by using conditioned medium from concanavalin A-stimulated lymphocytes. The ability of various murine type C viruses to infect these normal T cell cultures was examined and compared with their ability to infect transformed T cells. All of the viruses examined, including a thymotropic radiation leukemia virus, were unable to infect and replicate in normal T cells but readily did so in transformed T cells.
D000818:Animals; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D008223:Lymphoma; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008979:Moloney murine leukemia virus / Q000254:growth & development; D009374:Neoplasms, Experimental; D009381:Neoplasms, Radiation-Induced; D012328:RNA Viruses / Q000254:growth & development*; D012190:Retroviridae / Q000254:growth & development*; D013601:T-Lymphocytes / Q000378:metabolism*; D014774:Virulence; D014779:Virus Replication