title: Response of mibolerone-treated chickens to infectious bursal disease virus.
abstract: The response of mibolerone-treated chickens to infectious bursal disease virus (IBDV) was studied. Chickens fed a ration containing mibolerone at 1.5 parts per million (ppm) developed bursal atrophy by 4 weeks of age. No indication was found that mibolerone prevented IBDV infection even after 7 weeks of feeding. Furthermore, only chickens treated with mibolerone died when infected with IBDV at 2 or 3 weeks of age, and treated chickens had more severe clinical signs than did untreated controls when infected at 4-8 weeks of age. Chickens fed mibolerone had lower body weights than unmedicated controls, and apparently had a lower antibody response to IBDV and to bovine serum albumin.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D001835:Body Weight; D002060:Bursa of Fabricius / Q000187:drug effects; D002645:Chickens; D005260:Female; D007116:Immunization, Passive; D007243:Infectious bursal disease virus / Q000276:immunology; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011201:Poultry Diseases / Q000517:prevention & control*; D012088:Reoviridae Infections / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral; D009277:Nandrolone; C100075:mibolerone