[Results of clinical application of methods of individual selection of chemotherapeutic preparations in the treatment of gliomas].
The method of autoradiography for testing the efficacy of cytostatics with subsequent individually chosen chemotherapy is one of the components of rational therapy for neuro-oncological patients. Purposeful chemotherapy was applied in 17 cases with gliomas. Favourable results were recorded in 70.6% of them. Twelve patients received regular courses of treatment with one agent which inhibited DNA synthesis in vitro most potently (in 7 the therapeutic result was favourable), 5 patients were given course of polychemotherapy (favourable effect in 100%). Prolonged survival and a good remission allow autoradiography to be recommended as a method for the individual choice of antiblastic agents.
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001254:Astrocytoma / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000188:drug therapy*; D004338:Drug Combinations; D005625:Frontal Lobe; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D009837:Oligodendroglioma / Q000188:drug therapy*; D010296:Parietal Lobe; D005641:Tegafur / Q000008:administration & dosage; D013702:Temporal Lobe; D014747:Vinblastine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D004338:Drug Combinations; D005641:Tegafur; D014747:Vinblastine; D008558:Melphalan; D008727:Methotrexate
Rezul'taty klinicheskogo primeneniia metodiki individual'nogo podbora khimiopreparatov pri lechenii gliom.