Chemotaxin-induced changes in cyclic adenosine monophosphate levels in human neutrophils.
Incubation of the chemotactic agent N-formyl-methionyl-leucyl-phenylalanine with human neutrophils produced a rapid elevation of the intracellular level of cyclic adenosine monophosphate (cAMP). This cAMP spike occurred within 30 s after exposure and returned to normal by 5 min.
D002630:Chemotactic Factors / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D008715:Methionine / Q000031:analogs & derivatives*; D009239:N-Formylmethionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology*; D013997:Time Factors
D002630:Chemotactic Factors; D009842:Oligopeptides; D009239:N-Formylmethionine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008715:Methionine; D000242:Cyclic AMP