Familial occurrence of trophoblastic disease - report of recurrent molar pregnancies in sisters in three families.
Three families are described in which trophoblastic desease occurred in one or more pregnancies in two or more sisters. The possible role of genetic factors in the etiopathogenesis of hydatidiform mole is reviewed in light of these data. We believe this to be the first report of familial occurrence of molar pregnancies.
D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000209:etiology* / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D010375:Pedigree; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000235:genetics*; D014594:Uterine Neoplasms / Q000209:etiology* / Q000235:genetics