Solute asymmetric energy of transfer (channel partition) model and the cause of cancer.
A model for all solute transport is outlined in which flux rates and intracellular accumulation depend on partition barriers to the solute at the inner and outer channel openings of the intramembrane particles. Carcinogens would bind at and enlarge the outer channel opening, allowing increased influx of Na and Ca and thus triggering cellular replication.
D002455:Cell Division; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004735:Energy Transfer; D007473:Ion Channels / Q000378:metabolism*; D008566:Membranes / Q000378:metabolism; D008962:Models, Theoretical; D009369:Neoplasms / Q000378:metabolism*; D012996:Solutions; D014867:Water
D007473:Ion Channels; D012996:Solutions; D014867:Water