Decreased urinary glucose excretion and plasma cholesterol level in non-insulin dependent diabetic patients with guar.
The effect of guar gum in lowering urinary glucose excretion and plasma cholesterol was studied in ten sulphonylurea-treated non-insulin dependent diabetic patients during a four week treatment period. The 24-hour urinary glucose excretion fell gradually and increased again to pretreatment value after withdrawal of guar. The glucose output dropped by 33 and 51% in the 3rd and 4th week of the guar treatment period (p less than 0.01) compared to the mean of the pre-plus postguar level. The plasma cholesterol concentration also fell significantly during treatment with guar (p less than 0.01).
D000368:Aged; D002482:Cellulose / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000097:blood* / Q000652:urine; D003927:Diet, Diabetic; D004043:Dietary Fiber / Q000627:therapeutic use*; D005260:Female; D005685:Galactans / Q000627:therapeutic use*; D006029:Glycosuria; D006801:Humans; D008297:Male; D008351:Mannans / Q000627:therapeutic use*; D008875:Middle Aged; D053149:Plant Gums; D011134:Polysaccharides / Q000627:therapeutic use*
D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; D002482:Cellulose; D002784:Cholesterol; C007894:guar gum