title: Effect of purified zearalenone on early gestation in gilts.
abstract: Purified zearalenone (Z) was added to the diet of gilts from d 2 to 15 postmating. Gilts received either 0, 5, 15, 30, 60 or 90 ppm Z (three to five gilts per dose) in 1.8 kg of feed daily. Serum concentrations of progesterone and estradiol-17 beta were determined weekly. On d 13 to 15 and 40 to 43 postmating, blood samples were drawn from a cannula at 20 min intervals for 4 h and analyzed for luteinizing hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL). Gilts were killed 40 to 43 d postmating and embryonic development was assessed. Treatment with 5, 15 or 30 ppm Z had no effect on embryonic development when compared with 0 ppm. No fetuses were present in gilts fed 60 to 90 ppm Z, but two gilts given 60 ppm Z had remnants of fetal membranes in the uterus. The histologic appearance of reproductive tract tissues from the gilts given 60 ppm Z was similar to that from pregnant gilts. Tissues from gilts given 90 ppm Z appeared to be stimulated by both estrogen and progesterone. Serum concentrations of progesterone were decreased at 2, 3 and 6 wk postbreeding in gilts fed 60 and 90 ppm Z. Serum concentrations of estradiol-estradiol-17 beta were decreased at 4 wk postbreeding in gilts fed 60 and 90 ppm Z.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000821:Animal Feed; D000818:Animals; D004717:Endometrium / Q000033:anatomy & histology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood / Q000378:metabolism; D012118:Resorcinols / Q000494:pharmacology*; D013552:Swine / Q000033:anatomy & histology / Q000502:physiology*; D014599:Uterus / Q000187:drug effects; D015025:Zearalenone / Q000494:pharmacology*
chemical_list: D012118:Resorcinols; D011374:Progesterone; D004958:Estradiol; D015025:Zearalenone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone