Comparison of cefoperazone, cefotaxime, and moxalactam (LY127935) against aerobic gram-negative bacilli.
This study compares the minimum inhibitory concentrations of cefoperazone, cefotaxime, and moxalactam (LY127935) for 446 aerobic gram-negative bacillary isolates and further compares the minimum inhibitory concentrations of LY127935 and these third-generation cephalosporins with those of thienamycin for Pseudomonas aeruginosa. Each antibiotic at low concentrations inhibited nearly all Enterobacteriaceae tested. Minimum inhibitory concentrations for P. aeruginosa were higher, but for a majority of strains they fell below achievable serum levels. Thienamycin and cefoperazone showed significantly greater antipseudomonal activity than did cefotaxime or LY127935. Cefoxitin-inducible resistance to LY127935 and the two cephalosporins was demonstrated among Enterobacter species but did not occur with thienamycin.
D000332:Aerobiosis; D001419:Bacteria / Q000187:drug effects*; D001769:Blood; D002438:Cefoperazone; D002439:Cefotaxime; D002440:Cefoxitin / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D003470:Culture Media; D004352:Drug Resistance, Microbial; D006801:Humans; D009070:Moxalactam; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000187:drug effects
D002511:Cephalosporins; D002513:Cephamycins; D003470:Culture Media; D002440:Cefoxitin; D002438:Cefoperazone; D002439:Cefotaxime; D009070:Moxalactam