Postirradiation malignant fibrous histiocytoma.
Three patients who were treated successfully with postoperative external radiation therapy for ovarian carcinoma, endometrial adenocarcinoma and bilateral retinoblastoma respectively developed years later malignant fibrous histiocytoma (MFH) within the irradiated field. MFH is a recently described soft tissue sarcoma known for its dual fibroblastic and histiocytic differentiation resulting in a pleomorphic histologic appearance.
D000230:Adenocarcinoma / Q000532:radiotherapy; D000368:Aged; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000532:radiotherapy; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000209:etiology*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000532:radiotherapy; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012175:Retinoblastoma / Q000532:radiotherapy; D012306:Risk; D012983:Soft Tissue Neoplasms / Q000209:etiology*; D014594:Uterine Neoplasms / Q000532:radiotherapy