Striatal dopamine receptors in Alzheimer-type dementia.
Dopamine D1 and D2 receptors were studied in putamen of post-mortem brains from controls and patients with Alzheimer-type dementia (ATD). A significant reduction in dopamine D2 receptors was observed in ATD, whereas dopamine D1 receptors were unchanged. Neurochemical markers of striatal acetylcholine and GABA-containing neurones were also within the normal range. The results are consistent with a loss of D2 receptors located on cortico-striatal neurones in putamen of some ATD patients. In contrast, markers of intrinsic neurones may remain unchanged.
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003704:Dementia / Q000378:metabolism*; D005260:Female; D006719:Homovanillic Acid / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000032:analysis* / Q000201:enzymology; D011954:Receptors, Dopamine / Q000032:analysis*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D005680:gamma-Aminobutyric Acid; D002795:Choline O-Acetyltransferase; D006719:Homovanillic Acid