title: Study of the in vitro activity of new cephalosporins on strains of Neisseria gonorrhoeae of the Toulouse region.
abstract: The study was carried out with 50 strains of gonococci. Susceptibility to the antibiotics was determined by standard sensitivity test, by systematic test for beta-lactamase and by measurement of the MICs. The cephalosporins tested were: moxalactam, cefotaxime, ceftriaxone, cefotiam, cefoxitin, cefazolin and cephalothin. Their activities were also compared with other beta-lactams, namely penicillin and ampicillin. The efficacy in vitro of the cephalosporins: in the lead, ceftriaxone, remarkably active, with cefotaxime following very close, and then moxalactam with cefotiam a little behind, and finally all the other beta-lactams tested. The median MICs of the new cephalosporins (moxalactam, cefotaxime, ceftriaxone and cefotiam) were at least 10 times greater than those of the other beta-lactams tested. The MIC values observed with a resistant strain (penicillin, ampicillin; MIC 256 microgram/ml) never exceed the maximum values found with the 50 susceptible strains.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D002437:Cefazolin / Q000494:pharmacology; D002439:Cefotaxime; D015310:Cefotiam; D002440:Cefoxitin / Q000494:pharmacology; D002443:Ceftriaxone; D002511:Cephalosporins / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology; D002513:Cephamycins / Q000494:pharmacology; D005260:Female; D005602:France; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009070:Moxalactam; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D010406:Penicillins / Q000494:pharmacology
chemical_list: D002511:Cephalosporins; D002513:Cephamycins; D010406:Penicillins; D002440:Cefoxitin; D002443:Ceftriaxone; D000667:Ampicillin; D015310:Cefotiam; D002437:Cefazolin; D002439:Cefotaxime; D002512:Cephalothin; D009070:Moxalactam