[Effect of lithium preparations on the toxic effects of adrenaline].
Experiments on rats have shown that intravenous injection of adrenaline in a dose of 0.3-0.4 mg/kg causes cardiac arrhythmia. In this case the primary arrhythmia developing immediately after adrenaline injection is followed by the recovery of sinusal rhythm which was replaced by the secondary arrhythmia. Apart from arrhythmias, there developed pulmonary edema. The animals died 2--3 minutes after adrenaline injections. Lithium chloride and lithium hydroxybutyrate removed the secondary arrhythmia and pulmonary edema. Lithium hydroxybutyrate has proved to be more effective.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D002712:Chlorides / Q000627:therapeutic use; D004837:Epinephrine / Q000037:antagonists & inhibitors*; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008094:Lithium / Q000627:therapeutic use*; D018021:Lithium Chloride; D008297:Male; D009942:Organometallic Compounds; D011654:Pulmonary Edema / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats
D000889:Anti-Arrhythmia Agents; D002712:Chlorides; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium; D018021:Lithium Chloride; D004837:Epinephrine
Vliianie preparatov litiia na toksicheskie éffekty noradrenalina.