[Hormonal regulation of heparin clearance in immobilization stress in rats].
Intensity of heparin (H) clearance is reduced and the latter gets retained in the blood flow in rats subjected to immobilization stress. A stable fall is seen when immobilization is continued not less than 20 minutes. A decrease in the rate of H secretion from the blood flow is associated with ACTH concentration in the blood. Immobilization stress does not affect the intensity of H clearance in the animals with ACTH-release blocked by DOCA administration. ACTH use was conducive to a further decrease in H clearance intensity in animals exposed to immobilization. The rate of H secretion from the blood flow in this case is minimum and significantly differs from the rate of H clearance in animals immobilized without ACTH administration.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D006493:Heparin / Q000097:blood*; D007103:Immobilization; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D051381:Rats; D013312:Stress, Physiological / Q000097:blood*; D013462:Sulfur Radioisotopes; D013997:Time Factors
D013462:Sulfur Radioisotopes; D003900:Desoxycorticosterone; D000324:Adrenocorticotropic Hormone; D006493:Heparin
Gormonal'naia reguliatsiia klirensa geparina pri immobilizatsionnom stresse u krys.