[Persistence of attenuated poliomyelitis virus in the organs of vaccinated animals].
Experiments in cotton rats weighing 60-80 g orally vaccinated with gradually decreasing doses of live poliovaccine type II causing immunological changes of varying intensity demonstrated the attenuated poliomyelitis virus to penetrate the CNS, lungs, and spleen quite regularly. The virus could be isolated from the cytoplasmic extracts of these organs for up to 45 days, from the spleen for 60 days. Penetration of the virus into the CNS did not result in the development of disease. The long-term persistence of the virus in the organs was accompanied by the development of inflammatory-degenerative changes in the CNS and in some cases by pneumonia.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002472:Cell Transformation, Viral; D002490:Central Nervous System / Q000382:microbiology; D007114:Immunization; D008168:Lung / Q000382:microbiology; D017955:Poliovirus / Q000276:immunology / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage*; D051381:Rats; D013154:Spleen / Q000382:microbiology; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage
D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral; D014613:Vaccines, Attenuated
O persistentsii attenirovannogo virusa poliomielita v organakh vaktsinirovannykh zhivotnykh.