Abrogation of radiation leukemia virus-induced lymphomagenesis by antisera to thymotropic but not to ecotropic or dual-tropic viruses.
Leukemia induction by culture-grown thymotropic radiation leukemia virus or by tumor-derived virus present in cell-free tumor extracts was abrogated by incubation of either virus with anti-thymotropoc virus serum, but not by antiserum raised against ecotropic or dual-tropic (mink cell focus-inducing type) viruses that were isolated from radiation leukemia virus-induced thymic leukemias. Thus, virus similar or identical to the cultured thymotropic leukemogenic species may also be the major biologically active principle in tumor-derived extracts, even though the latter also contain viruses of the dual-tropic, mink cell focus-inducing type class.
D000818:Animals; D002460:Cell Line; D007106:Immune Sera; D009052:Leukemia Virus, Murine / Q000276:immunology / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000382:microbiology*; D008223:Lymphoma / Q000382:microbiology*; D051379:Mice; D008907:Mink; D009500:Neutralization Tests; D013945:Thymoma / Q000382:microbiology; D013953:Thymus Neoplasms / Q000382:microbiology; D014965:X-Rays
D007106:Immune Sera