Lung tumors induced by chronic inhalation of 1,2-dibromo-3-chloropropane in B6C3F1 mice.
1,2-Dibromo-3-chloropropane (DBCP) was inhaled by B6C3F1 mice of each sex at concentrations of 0.6 or 3.0 ppm for 6 h/day, 5 days/week, for 103 weeks. Untreated controls consisted of 50 mice of each sex. All surviving animals were killed at 104 weeks. Survival in the high-dose groups of female mice was significantly shorter than that in the corresponding controls. Alveolar-bronchiolar adenomas or carcinomas occurred in both male and female mice with dose-related trends (P < 0.007) in males and (P < 0.002) in females. Papillary carcinomas in the lung occurred in low-dose female mice at an increased incidence compared with controls (P < 0.006). Many induced tumors were morphologically different than those in controls.
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced*; D002291:Carcinoma, Papillary / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005260:Female; D006846:Hydrocarbons, Halogenated / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental; D011407:Propane / Q000008:administration & dosage / Q000031:analogs & derivatives*
D006846:Hydrocarbons, Halogenated; C007318:1,2-dibromo-3-chloropropane; D011407:Propane