Experimental amoebic infection in guinea-pigs immunized with low grade amoebic infection.
Guinea-pigs were immunzied with a low grade amoebic infection, either intracaecally or intramesenterically. The immunized animals were challenged with a virulent strain of Entamoeba histolytica. Some of the animals, immunized via the intracaecal route were challenged repeatedly. 10 to 30% of immunized animals developed caecal lesions compared with 92.8% of non-immunized animals. The percentage of protection in animals challenged repeatedly was greater than in those challenged once. Neither immunized nor non-immunized guinea-pigs developed hepatic abscesses. It appears that prior low grade infection could lead to resistance to subsequent amoebic challenge.
D000562:Amebiasis / Q000517:prevention & control*; D000818:Animals; D000906:Antibodies / Q000032:analysis; D002432:Cecum / Q000469:parasitology; D004748:Entamoeba histolytica / Q000276:immunology; D004749:Entamoebiasis / Q000276:immunology / Q000517:prevention & control*; D006168:Guinea Pigs; D007109:Immunity; D007114:Immunization / Q000379:methods; D014612:Vaccines / Q000008:administration & dosage
D000906:Antibodies; D014612:Vaccines