PMR and 13C-NMR spectroscopy of tropane and N-substituted nortropane spirohydantoins.
The preferred conformations of a pharmacologically interesting series of N-substituted nortropane spirohydantoins were determined from PMR and 13C-NMR data to permit a structure-activity relationship study.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D004578:Electron Spin Resonance Spectroscopy; D006827:Hydantoins / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D009662:Nortropanes / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship; D014326:Tropanes / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D006827:Hydantoins; D009662:Nortropanes; D014326:Tropanes