title: Longitudinal study of calcium metabolism in male puberty. II. Relationship between mineralization and serum testosterone.
abstract: Height velocity, bone mineral content (BMC), serum concentrations of alkaline phosphatase (AP), testosterone, dehydroepiandrosterone (DHEA) and androstenedione (A-dione) were determined as a part of a longitudinal study of calcium metabolism in normal male puberty. The time of maximal increase (Tm) in concentrations was calculated for 20 boys from a curve-fitting analysis program. Highly significant correlations were found between Tm testosterone and Tm BMC (r = 0.73, p less than 0.001); Tm AP and Tm BMC (r = 0.68, p less than 0.001). The mean difference in time between Tm testosterone and Tm BMC was 4.7 months and between Tm AP and Tm testosterone 0.7 month. Our data indicate a very close relationship between testosterone, osteoblastic activity, and mineralization in normal male puberty, whereas the adrenal androgens do not seem to have a major influence on the mineralization at the male puberty growth spurt phase.
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood*; D000735:Androstenedione / Q000097:blood; D001846:Bone Development; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002648:Child; D003687:Dehydroepiandrosterone / Q000097:blood; D003718:Denmark; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008903:Minerals / Q000378:metabolism*; D011627:Puberty; D013739:Testosterone / Q000097:blood*
chemical_list: D008903:Minerals; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone; D000469:Alkaline Phosphatase; D002118:Calcium