Trypsin-induced masking of tetrodotoxin receptor of the sodium channels in mollusc neurons.
At the early stage of trypsin treatment of mollusc neurons tetrodotoxin cannot block the Na+ current. In the course of further exposure of neurones to trypsin, tetrodotoxin-sensitivity is restored completely, so its temporal loss results from shielding rather than destruction of the tetrodotoxin-binding site. Pronase and papain do not affect the tetrodotoxin action on the Na+ current.
D000818:Animals; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008195:Lymnaea / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011955:Receptors, Drug / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D013779:Tetrodotoxin / Q000378:metabolism*; D014357:Trypsin / Q000494:pharmacology*
D007473:Ion Channels; D011955:Receptors, Drug; D013779:Tetrodotoxin; D012964:Sodium; D014357:Trypsin