Uptake of serotonin liberated by irradiation of rabbits and mice.
The radiation-induced release of serotonin (5-HT) in rabbits and mice has a linear dose-response relationship over a short range of approximately 0.75 Gy. In both animal species a threshold value is present, which is 1 Gy for rabbits and 5 Gy for mice. Doses higher than those falling in the linear range give rise to lower plasma 5-HT values. These lower values occur concurrent with increased splenic 5-HT levels. Stimulated 5-HT uptake of the spleen may be responsible for the diminished increase in plasma 5-HT.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits; D011829:Radiation Dosage; D012701:Serotonin / Q000097:blood / Q000378:metabolism* / Q000528:radiation effects; D013154:Spleen / Q000378:metabolism / Q000528:radiation effects
D012701:Serotonin