[Systemic antibiotic prophylaxis in elective colon surgery. Results of a controlled study].
A prospective controlled, randomized trial was carried out among 70 patients undergoing elective colonic surgery; 31 patients received a systemic prophylaxis with cefotaxime (3 h) before surgery for 4 days and 29 patients were controls. The large bowel preparation consisted of whole gut irrigation with 0.9% NaCl and Paromomycin 1 g/l. Both groups were well matched after randomization. The rate wound infections in the control group was 28% and, in the test group, 6.4% (p less than 0.05, chi2-test). A trend toward a lower rate of urinary tract infections, an astomosic dehiscences and septicemic complications was recognizable in the test group, but not significant.
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002439:Cefotaxime; D002511:Cephalosporins / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003106:Colon / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002439:Cefotaxime
Die systemische Antibioticumprophylaxe in der elektiven Colonchirurgie. Ergebnisse einer kontrollierten Studie.