Effect on dental caries of a stannous fluoride-calcium pyrophosphate dentrifice in an adult population: one-year results.
The first year of a two-year double-blind clinical trial of the anticaries effectiveness of a stannous fluoride-calcium pyrophosphate (SnF2-CPP) dentifrice as compared to a placebo control dentifrice involved 1,337 adult subjects, 18 to 78 years of age. Adult subjects were examined for dental caries at a baseline examination and after one year of ad lib dentifrice usage by an experienced clinical examiner using a visual-tactile examination and a radiographic evaluation. Results of the study after one year indicate a significant (P < 0.05) 33.3% difference in new caries formation with use of the SnF2-CPP dentifrice as compared to the placebo control based on the DMFS score.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002131:Calcium Pyrophosphate / Q000627:therapeutic use*; D002327:Cariostatic Agents; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D011756:Diphosphates / Q000627:therapeutic use*; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010919:Placebos; D014002:Tin Fluorides / Q000627:therapeutic use*
D002327:Cariostatic Agents; D003802:Dentifrices; D011756:Diphosphates; D010919:Placebos; D014002:Tin Fluorides; D005459:Fluorides; D002131:Calcium Pyrophosphate