[Value of cefotaxime in the treatment of female asymptomatic N. gonorrhoeae carriers (author's transl)].
Thirty women with asymptomatic genital gonococcal contamination were cured with one single i.m. injection of 1 g cefotaxime. Seven hours after treatment, the antibiotic level in cervical fluid was found equivalent to the minimal bactericidal concentration for gonococcus strains. But cefotaxime does not appear useful in the prevention of meningococcal pharyngeal carriage.
D000328:Adult; D002353:Carrier State / Q000188:drug therapy*; D002439:Cefotaxime; D002511:Cephalosporins / Q000378:metabolism / Q000627:therapeutic use*; D002582:Cervix Mucus / Q000378:metabolism; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D012463:Saliva / Q000378:metabolism
D002511:Cephalosporins; D002439:Cefotaxime
Intérêt du céfotaxime dans le traitement du portage asymptomatique de gonocoque chez la femme.