title: HSV-1 infection inhibits procollagen and protein secretion from normal and ataxia telangiectasia cultured skin fibroblasts.
abstract: Human skin fibroblasts derived from a healthy individual and from a child with the genetic disorder ataxia telangiectasia were infected with herpes simplex virus type 1 (HSV-1). The virus infection did not affect the synthesis of procollagen but inhibited its release from the cells.
mesh_terms: D001260:Ataxia Telangiectasia / Q000473:pathology*; D002478:Cells, Cultured; D002648:Child; D005347:Fibroblasts / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D011347:Procollagen / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D018139:Simplexvirus / Q000254:growth & development*
chemical_list: D011347:Procollagen; D011506:Proteins