Control of cell proliferation in transformed cells.
We have presented evidence that T-ag of SV40 reactivates silent rRNA genes. Since rRNA synthesis correlates with growth rates, it is conceivable that T-ag may stimulate cell proliferation by acting on rRNA genes. In SV40-transformed, T-positive cells, this would and does result in continuous cell proliferation, beyond the limits of that in normal cells.
D000818:Animals; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor; D002455:Cell Division; D002472:Cell Transformation, Viral; D005796:Genes; D051379:Mice; D012335:RNA, Ribosomal / Q000235:genetics*; D013539:Simian virus 40 / Q000276:immunology; D014412:Tumor Virus Infections / Q000235:genetics*
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor; D012335:RNA, Ribosomal