title: Metabolic aspects of psoriasis: the basis for specific therapy.
abstract: Psoriasis, like diabetes, is a multifactorial genetic disease with complex interactions of deranged metabolism. Factors that affect epidermal differentiation and proliferation include cyclic nucleotide interactions, polyamine metabolism, cell surface--cytoskeleton interactions, and arachidonic acid--prostaglandin cascade. Evidence indicates that pharmacologic manipulation of the so-called critical metabolic systems not only may help us to understand the pathophysiology of psoriasis but also may yield improved treatments for the disease.
mesh_terms: D001095:Arachidonic Acids / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D011073:Polyamines / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D011565:Psoriasis / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D012867:Skin / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D006680:HLA Antigens; D011073:Polyamines; D011458:Prostaglandins E; D011460:Prostaglandins F; D000242:Cyclic AMP; D006152:Cyclic GMP