Cross-reactive anti-vesicular stomatitis virus (VSV) cytotoxic T lymphocytes recognize the major surface glycoprotein.
The major surface glycoprotein (G) of vesicular stomatitis virus (VSV) was purified and incorporated into lipid vesicles containing the purified hemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins of Sendai Virus. These lipid vesicles were then used to modify the render target cells susceptible to lysis by anti-VSV cytotoxic T lymphocytes. The results obtained provide direct evidence that the G protein is a target antigen for specific and cross-reactive anti-VSV cytotoxic T lymphocytes. The significance of this work is discussed.
D000818:Animals; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D008297:Male; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000276:immunology; D013280:Stomatitis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*
D006023:Glycoproteins; D008565:Membrane Proteins