[Clinical resistance of herpetic keratitis to antiviral agents (author's transl)].
Clinical resistance of herpetic keratitis to antiviral agents constitutes one of the reasons for failure of treatment after their administration. A retrospective study of 42 cases of superficial herpetic keratitis resistant to IDU, IDU and IDC, and Ara-A demonstrated that in 2 out of 3 cases this resistance appeared in patients previously treated locally with antiviral compounds for anterior ocular lesions. Patients resistant to IDU were then treated with Ara-A, and those not responding to Ara-A, with TFT. Resistance may be observed following this new treatment during the subsequent relapses.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D006801:Humans; D007065:Idoxuridine / Q000627:therapeutic use; D007635:Keratitis, Dendritic / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D018139:Simplexvirus / Q000187:drug effects; D014740:Vidarabine / Q000627:therapeutic use
D000998:Antiviral Agents; D014740:Vidarabine; D007065:Idoxuridine
La résistance clinique des kératites herpétiques aux antiviraux.