A comparison of the activity in vitro of different cephalosporins: cephalothin, cephradine, cephacetrile, cefaclor, cefuroxime and cefotaxime.
6-cephalosporins (cephalothin, cephradine, cephacetrile, cefaclor, cefuroxime, cefotaxime) has been tested in vitro against 212 gram negative bacteria and 60 Staphylococci. Cefuroxime and especially Cefotaxime showed the highest activity against the gram negative bacteria, with a very low MIC. Cefotaxime also acted fairly well against several strains of Pseudomonas. Of the six cephalosporins tested, cephalothin gave the best results against the Staphylococci.
D002433:Cefaclor / Q000494:pharmacology; D002439:Cefotaxime; D002444:Cefuroxime / Q000494:pharmacology; D002505:Cephacetrile / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology; D002515:Cephradine / Q000494:pharmacology; D004754:Enterobacter / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D002511:Cephalosporins; D002433:Cefaclor; D002515:Cephradine; D002505:Cephacetrile; D002439:Cefotaxime; D002444:Cefuroxime; D002512:Cephalothin