Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus.
Specific initiation of transcription of Rous sarcoma virus by RNA polymerase II was obtained in a cell-free system using cloned RSV DNA as template. The site of initiation is located in the common "C" region of the long terminal repeat (LTR), 23 bp downstream from the promoter-like sequence TATTTAAG. This finding indicates that the basic information necessary for RSV transcription lies within the viral genome.
D000260:Adenoviruses, Human / Q000235:genetics; D001358:Avian Sarcoma Viruses / Q000235:genetics*; D001483:Base Sequence; D002478:Cells, Cultured; D004279:DNA, Viral / Q000235:genetics*; D005809:Genes, Regulator; D005814:Genes, Viral; D006801:Humans; D009876:Operon; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D004279:DNA, Viral; D012333:RNA, Messenger