Epstein-Barr-virus-carrying lymphoma in a patient with ataxia-telangiectasia.
An undifferentiated lymphocytic lymphoma of mesenteric lymph nodes occurred in a young boy with ataxia-telangiectasia. Two independent tests, Epstein-Barr virus (EBV)-cRNA/DNA hybridisation and EBV DNA/DNA reassociation kinetic analysis, showed 53 and 68 EBV genome equivalents per cell respectively, which was compatible with an EBV-genome-carrying tumour. Whether this was a polyclonal lymphoproliferation or a monoclonal tumour could not be determined owing to lack of suitable material. The presence of EBV genomes should be sought in lymphomas arising in ataxia-telangiectasia and other immunodeficiencies.
D000008:Abdominal Neoplasms / Q000209:etiology / Q000382:microbiology*; D000914:Antibodies, Viral / Q000032:analysis; D001260:Ataxia Telangiectasia / Q000150:complications*; D002648:Child; D004279:DNA, Viral; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000382:microbiology*; D008297:Male; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral
D000914:Antibodies, Viral; D004279:DNA, Viral; D012367:RNA, Viral