Lack of association between the elevation of adenosine 3',5'-cyclic monophosphate and the potentiation of the interferon-induced antiviral state by noradrenaline in normal and tumoral rat cells.
Rat interferon (IF) induced a moderate and persistent elevation of adenosine 3',5'-cyclic monophosphate (cAMP) after 6 h of contact with rat embryo fibroblasts (REFs), whereas in rat glial tumoral c6 cells IF did not enhance cAMP. Noradrenaline potentiated the antiviral state of REFs treated for 2 h or more with IF and increased cAMP in these cells, but it did not potentiate the IF-induced antiviral state of C6 cells. However, as the control cells, IF-treated C6 cells responded to catecholamines by a 100-fold or more increase in cAMP. This suggested that cAMP was not primarily involved in the establishment of the antiviral state.
D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism*; D005347:Fibroblasts; D007372:Interferons / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D009457:Neuroglia; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D014762:Viral Interference / Q000187:drug effects*
D007372:Interferons; D000242:Cyclic AMP; D007545:Isoproterenol; D009638:Norepinephrine