Induction of syncytia by simian sarcoma virus type I (SSV-I/SSAV-I) in several human transformed cell lines.
Simian sarcoma virus type I (SSV-I/SSAV-I) induced syncytia formation in human cells derived from malignant tumors (KB, HEp-2 and HeLa cells) and human cells transformed by tumor viruses (RSa, RSb and KC cells) as well as rat XC cells. However, SSV-I/SSAV-I did not induce syncytia formation in human cells derived from normal embryos (WI-38, HEL and HEC). Syncytia-inducing activity of SSV-I/SSAV-I was neutralized by anti-SSV-I/SSAV-I serum, indicating that syncytia formation was SSV-I/SSAV-I mediated.
D002459:Cell Fusion; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D003588:Cytopathogenic Effect, Viral; D006367:HeLa Cells; D006801:Humans; D012190:Retroviridae / Q000502:physiology*; D012842:Sarcoma Virus, Woolly Monkey / Q000502:physiology*