Bovine-derived spinal cord protein (SCP) protects guinea pigs from experimental allergic encephalomyelitis (EAE) - a confirmatory report.
An axonally localized, non-encephalitogenic protein derived from bovine spinal cord can protect guinea pigs from EAE following challenge with bovine myelin basic protein. Protection from neurologic signs is significant although CNS pathology is present. The protective regimen apparently varies depending upon the species and strain of animal; this specific requirement may account for a previous negative report.
D000818:Animals; D001835:Body Weight; D001921:Brain / Q000473:pathology; D003574:Cytochrome c Group / Q000494:pharmacology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000517:prevention & control*; D006168:Guinea Pigs; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D010243:Paralysis / Q000175:diagnosis; D013116:Spinal Cord / Q000473:pathology
D003574:Cytochrome c Group; D009419:Nerve Tissue Proteins