Cyclic nucleotide changes in aortic segments derived from hypertensive rabbits.
Mean blood pressure increase was produced by: (1) renal constriction plus contralateral nephrectomy, and (2) cadmium acetate ingestion. Blood pressure was measured directly via the middle ear artery. Cyclic nucleotide levels were determined by 125I-radioimmunoassay. Levels of cAMP were reduced in both hypertensive subgroups when compared to controls. The altered cAMP levels suggest a relationship of this nucleotide to the maintenance of increased blood pressure.
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002104:Cadmium / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006973:Hypertension / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D009392:Nephrectomy; D011817:Rabbits; D013997:Time Factors
D002104:Cadmium; D000242:Cyclic AMP