title: Effects of centrally administered endogenous opioid peptides on drinking behavior, increased plasma vasopressin concentration and pressor response to hypertonic sodium chloride.
abstract: Intracerebroventricular (i.v.t.) administration of beta-endorphin or leucine5-enkephalin inhibited drinking behavior, the pressor response and increased plasma vasopressin concentration stimulated by an acute elevation in CSF sodium chloride concentration (10 microliter, 1 M NaCl i.v.t.). These effects of endogenous opioid peptides were prevented by naloxone, indicating opiate receptors were required for the biologic response. Drinking behavior associated with regulatory stimuli operant during dehydration was also inhibited by opioid peptides. beta-Endorphin (i.v.t.) delayed the onset and/or reduced the volume of water consumed in response to hypertonic sodium chloride (relative cellular dehydration), polyethylene glycol (hypovolemia) and food-associated drinking behavior. Inhibition of drinking did not appear related to sensory-motor dysfunction as another motivated behavior, eating (onset, amount consumed) was unaffected by beta-endorphin. It is concluded from these results that centrally administered endogenous opioid peptides inhibit sodium chloride-stimulated cerebral mechanisms affecting blood pressure and hydration.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects*; D004723:Endorphins / Q000494:pharmacology*; D004743:Enkephalin, Leucine; D004745:Enkephalins / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D007700:Kinetics; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D012965:Sodium Chloride / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D014667:Vasopressins / Q000097:blood*; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D004745:Enkephalins; D014667:Vasopressins; D009270:Naloxone; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D004743:Enkephalin, Leucine; D001615:beta-Endorphin