The collagen prolyl hydroxylase activity of hepatocytes and mesenchymal cells isolated from normal and regenerating rat liver.
Prolyl hydroxylase activity has been demonstrated in separate populations of hepatocytes and mesenchymal cells from normal rat liver, the amount in the mesenchymal cell preparation being about twice that found in an equal number of hepatocytes. At the third day after partial hepatectomy, there is a 2- to 3-fold rise in hepatocyte prolyl hydroxylase and a 5-fold rise in the mesenchymal cell enzyme content. Sham operation causes a less striking elevation of prolyl hydroxylase in the mesenchymal cell preparations and has no effect on the hepatocyte enzyme.
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008264:Macrophages / Q000201:enzymology; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D051381:Rats
D003094:Collagen; D011393:Procollagen-Proline Dioxygenase