[Structural-functional organization of protein hormone molecules].
Our experimental results and literature data based on present-day concepts of molecular evolution of proteins have formed the basis for a hypothesis on the structural-functional organization of protein hormone molecules. This hypothesis postulates the existence of three types of the peptide chain sites, which play different roles in the biological action of hormones, i.e. effector (active), acceptor (binding) and accessory ones. The local similarity spectra have been computed and used for a comparison of the amino acid sequences of related hormones belonging to different groups. The positions of maxima, slopes and minima in these spectra of the molecules of peptide and some protein hormones are correlated with a most probable localization of the effector, acceptor and accessory sites, respectively.
D000818:Animals; D005075:Biological Evolution; D006728:Hormones / Q000502:physiology*; D007700:Kinetics; D010455:Peptides / Q000502:physiology; D011506:Proteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology
D006728:Hormones; D010455:Peptides; D011506:Proteins; D011956:Receptors, Cell Surface
Nekotorye aspekty strukturno-funktsional'noĭ organizatsii molekul belkovykh gormonov.