Effect of triiodothyronine injection on levels of triiodothyronine and thyroid-stimulating hormone in sera and milk of lactating rats and in sera of their sucklings; precocious development of jejunal alpha-disaccharidases in the sucklings.
Administration of high doses of triiodothyronine (T3) for 4 days to lactating rats evokes an increase in T3 levels in their sera and milk, as well as in the sera of pups suckled by them. Thyroid-stimulating hormone levels in sera of mothers and sucklings are decreased. Suckling rats of T3-treated mothers exhibit a precocious increase in the activity of jejunal sucrase and maltase as well as in activity of several liver acid beta-glycosidases.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D000833:Animals, Suckling; D001835:Body Weight / Q000187:drug effects; D004186:Disaccharidases / Q000378:metabolism*; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects / Q000201:enzymology*; D007774:Lactation; D008099:Liver / Q000201:enzymology; D008892:Milk / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013393:Sucrase / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D000519:alpha-Galactosidase / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism
D014284:Triiodothyronine; D013972:Thyrotropin; D004186:Disaccharidases; D000520:alpha-Glucosidases; D000519:alpha-Galactosidase; D005966:Glucuronidase; D013393:Sucrase; D000118:Acetylglucosaminidase