Modification of radiation response by agents that elevate the intracellular c-AMP level.
A study has been made of the effects of drugs known to elevate c-AMP level on radiation-induced damage in thymocytes. The test used was the ability of the cells to exclude dye, beta-receptor stimulation and phosphodiesterase inhibition were found to induce radioresistance. The possible importance of the plasma membrane in connection with cytoplasmic factors is briefly discussed.
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000528:radiation effects; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000502:physiology*; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D011433:Propranolol / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology / Q000528:radiation effects*
D000628:Aminophylline; D011433:Propranolol; D000242:Cyclic AMP; D007545:Isoproterenol