Glutamate and aspartate: alteration of thresholds and response patterns of auditory neurons.
Iontophoretic application of the excitant amino acids glutamate and aspartate onto neurons in the chinchilla cochlear nucleus results in a lowering of the threshold of response to auditory stimuli. Neurons that display 'on'-type phasic responses to toneburst stimuli may become tonic, sustained responders with iontophoretic application of glutamate or aspartate. The ability of either glutamate or aspartate to effect changes in thresholds and response patterns of cochlear nucleus neurons is further evidence that one of these amino acids may be the afferent transmitter of the auditory nerve. The effects seen with these excitant amino acids may also provide insight into the underlying synaptic events involved in the generation of a particular response pattern.
D000818:Animals; D001224:Aspartic Acid / Q000502:physiology*; D001309:Auditory Threshold / Q000502:physiology*; D002682:Chinchilla; D005971:Glutamates / Q000502:physiology*; D007478:Iontophoresis; D009474:Neurons / Q000502:physiology; D009435:Synaptic Transmission; D000159:Vestibulocochlear Nerve / Q000502:physiology*
D005971:Glutamates; D001224:Aspartic Acid