title: [Short intravenous infusion of streptokinase in acute myocardial infarct].
abstract: A brief review is given about the results obtained with high-dose brief-duration intravenous streptokinase infusion in patients with evolving myocardial infarction. Feasibility and efficacy of the intracoronary and systemic approaches are compared. Coronary clot lysis occurs as frequently with the intravenous approach as with intracoronary application if treatment is initiated early. A longer clot lysis time often will be more than compensated by the earlier initiation of the intravenous therapy. Therefore, intravenous thrombolysis might be more effective in the salvage of at-risk myocardium. After intravenous thrombolysis coronary angiography should be performed on an elective basis 1-3 weeks after the acute infarction. At this time, about 60% of the patients have had a diameter stenosis of the infarct-related coronary artery of less than 65%. It appears that in these patients late reocclusion or reinfarction is a rare event, while it is frequent in patients with a more severe residual stenosis. Coronary angioplasty may be advisable in these latter patients.
mesh_terms: D000800:Angioplasty, Balloon; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003326:Coronary Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011379:Prognosis; D012008:Recurrence; D013300:Streptokinase / Q000627:therapeutic use*
chemical_list: D013300:Streptokinase
vernacular_title: Intravenöse Kurzinfusion von Streptokinase beim akuten Myokardinfarkt.