The effect of idiotype-specific and anti-ACA-1 sera on T cell subpopulations responding to H-2 antigens.
A xenogeneic anti-CBA-anti-C57BL/6 idiotype-specific serum reacted specifically only with CBA anti-C57BL/6 T cells. It inhibited T killers, T lymphocytes proliferating in one-way MLC and T cells which take part in the rejection of the cardiac allografts. However, it did not affect T suppressors and T MIF producers. Another antiserum, directed against ACA-1 (activated cell antigen), inhibited T killers of various specificities, but not T suppressors or T MIF producers. These results allow us to suggest that (1) the idiotype-like structures of T suppressors and T MIF producers differ from those of other T cell subpopulations responding to H-2 antigens; (2) ACA-1 is expressed on the surface of T killers, but not on T suppressors or T MIF producers; (3) T cells producing MIF form a separate subpopulation.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005260:Female; D006084:Graft Rejection; D006183:H-2 Antigens / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D006183:H-2 Antigens; D007130:Immunoglobulin Idiotypes