Cytochrome c oxidase activity and fatty acid oxidation in various types of human muscle.
Cytochrome c oxidase activity, carnitine concentration and oxidation rates of pyruvate and palmitate were determined in homogenates of various types of human skeletal muscle. Cytochrome c oxidase activity appeared to be closely related to the pyruvate oxidation rate, but its correlation with palmitate oxidation was less distinct. Trunk muscles oxidize less palmitate and have a lower cytochrome c oxidase activity per mg homogenate protein than leg muscles; soleus muscle biopsies showed higher activities than those of other leg muscles. Based on cytochrome c oxidase activity no large differences are found in palmitate oxidation rate between various types of human muscle. Cytochrome c oxidase activity and palmitate oxidation rate of muscles do not show an age dependency. The carnitine concentration is similar in all kinds of human skeletal muscle.
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D002331:Carnitine / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009928:Organ Specificity; D010084:Oxidation-Reduction; D010169:Palmitic Acids / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D051381:Rats
D005227:Fatty Acids; D010169:Palmitic Acids; D011773:Pyruvates; D003576:Electron Transport Complex IV; D002331:Carnitine