title: Nonequilibrium ion transport through pores. The influence of barrier structures on current fluctuations, transient phenomena and admittance.
abstract: In this paper is presented an investigation of the influence of the internal structure of pores in membranes on a) the time dependent macroscopic relaxation current after a voltage jump, b) the macroscopic frequency dependent admittance and c) the microscopic current fluctuations around stationary (nonequilibrium) states. All these quantities are determined by the time dependent transport equations, which are calculated with the use of the eigenvectors and eigenvalues of the matrix of coefficients, occurring in the transport equations. Numerical calculations for channels with up to 31 barriers are presented. The treatment of the fluctuations is done with the use of a general approach to nonequilibrium transport noise recently developed by one of the authors. It is shown that the influence of the internal barrier structure as, e.g., the height of central or decentral barriers in the pores is of great complexity. Nevertheless we hope that the calculations lead to a better understanding especially of the microscopic nonequilibrium transport fluctuations in complex systems.
mesh_terms: D007473:Ion Channels / Q000378:metabolism*; D008433:Mathematics; D008564:Membrane Potentials; D008566:Membranes / Q000378:metabolism*
chemical_list: D007473:Ion Channels