Suppression of human lymphocyte mitogen response by disrupted primate retroviruses of type C (baboon endogenous virus) and type D (PMFV).
Disrupted primate retroviruses of type C (baboon endogenous virus, BaEV) and type D (human cell line-derived isolate PMFV) considerably suppressed Concanavalin A - induced blastogenic response of human lymphocytes. Rauscher mouse leukemia virus (RLV) displayed a suppressive activity on murine splenic lymphocytes when tested under analogous conditions. The immunosuppressive activities were shown not to result from cytotoxicity or from virus-mitogen binding.
D000818:Animals; D003208:Concanavalin A; D006801:Humans; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008934:Mitogens; D010215:Papio; D011925:Rauscher Virus / Q000276:immunology; D012190:Retroviridae / Q000276:immunology*
D008934:Mitogens; D003208:Concanavalin A