Cyclic nucleotide elevation preceding catecholamine release in isolated dog adrenals.
Acetylcholine caused the rapid elevation of cAMP and cGMP levels with a peak within 30 sec in the medulla and in the perfusate preceding catecholamine release in isolated perfused dog adrenal glands. These responses to ACh were completely blocked by hexamethonium plus atropine. A functional role of cyclic nucleotides in catecholamine secretion mechanisms is discussed.
D000109:Acetylcholine / Q000494:pharmacology; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion
D002395:Catecholamines; D006584:Hexamethonium Compounds; D001285:Atropine; D000242:Cyclic AMP; D006152:Cyclic GMP; D000109:Acetylcholine