Biological properties of plaque-size variants of Sendai virus.
Large (RL)-and small (RS)-plaque variants of Sendai virus were isolated in culture of LLCMK2 cells in the presence of trypsin and their biological properties were determined. The RL variant was more virulent to mice than the RS variant. The RL variant had a higher growth rate than the RS variant in multiple-step growth in the presence of trypsin, but the two variants had an almost equal growth rate in its absence. Restoration of hemolytic activity in cleavage of the F protein of the RL variant were achieved by milder trypsin treatment than was needed for the RS variant.
D000818:Animals; D006387:Hemagglutination, Viral; D008297:Male; D051379:Mice; D009439:Neuraminidase / Q000378:metabolism; D010222:Parainfluenza Virus 1, Human / Q000145:classification* / Q000254:growth & development / Q000472:pathogenicity; D011498:Protein Precursors / Q000494:pharmacology; D014357:Trypsin / Q000494:pharmacology; D010948:Viral Plaque Assay
D011498:Protein Precursors; D009439:Neuraminidase; D014357:Trypsin