title: Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci.
abstract: The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may transform cells in the absence of gene mutations.
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006224:Cricetinae; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004622:Embryo, Mammalian; D005796:Genes / Q000187:drug effects*; D008647:Mesocricetus; D009154:Mutation
chemical_list: D001580:Benzopyrenes; D002273:Carcinogens; D001564:Benzo(a)pyrene; D004054:Diethylstilbestrol