Enhanced growth hormone response to clonidine in the spontaneously hypertensive rat.
Plasma concentrations of growth hormone (GH) were measured after administration of clonidine (0.5 mg/kg) to spontaneously hypertensive (SH) rats and normotensive Wistar Kyoto controls. All rats were pretreated with reserpine (10 mg/kg). The GH response to clonidine was significantly higher in SH rats than in controls, indicating that in SH rats the responsiveness of post-synaptic alpha-adrenergic structures in the hypothalamus may be increased.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004357:Drug Synergism; D013006:Growth Hormone / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D011292:Premedication; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D013268:Stimulation, Chemical
D011942:Receptors, Adrenergic, alpha; D012110:Reserpine; D013006:Growth Hormone; D003000:Clonidine