title: Pancreatic uptake of 99Tc stannous pyrophosphate in experimental viral pancreatitis in mice.
abstract: The pancreatic uptake of 99mTc stannous pyrophosphate (99mTc-PYP) in acute pancreatitis in mice induced by coxsackievirus B3 was studied. 99mTc-PYP uptake ratio, measured by the ratio of counts/min/g for the pancreas to counts/min/g for the skull, began to increase 2 days after virus inoculation and markedly increased on day 3 when necrosis of pancreatic acinar cells was evident. On day 5, 99mTc-PYP ratio reached a maximum (2.95 +/- 1.85, mean +/- SD) and histologically fine granules of calcification were seen in the necrotic acinar cells. Thereafter, cellular infiltrations increased and were most severe on day 7, but 99mTc-PYP ratio had began to decrease. On day 28, the necrotic areas of the pancreas were replaced with fatty cells and calcification was still present, though 99mTc-PYP ratio had decreased. The present findings may provide a basis for 99mTc-PYP imaging in cases of clinical viral pancreatitis.
mesh_terms: D000818:Animals; D003384:Coxsackievirus Infections / Q000000981:diagnostic imaging* / Q000378:metabolism; D029822:Enterovirus B, Human; D051379:Mice; D008807:Mice, Inbred BALB C; D010179:Pancreas / Q000378:metabolism; D010195:Pancreatitis / Q000000981:diagnostic imaging* / Q000378:metabolism; D011122:Polyphosphates; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism; D016698:Technetium Tc 99m Pyrophosphate; D014003:Tin Polyphosphates / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D011122:Polyphosphates; D014003:Tin Polyphosphates; C017742:technetium Tc 99m stannous pyrophosphate; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium