Germ-line reinsertions of AKR murine leukemia virus genomes in Akv-1 congenic mice.
Congenic mouse strains NIH,Akv-1 and NIH,Akv-2 carry the two high ecotropic virus-inducing loci of the AKR mouse on the NIH Swiss genetic background. Progeny tests of animals in three separate congenic families show that both Avk-1 and Akv-2 are stably transmitted as classical mendelian loci in these mice. However, during the process of inbreeding, additional chromosomal viral loci were detected in several NIH.Akv-1 sublines. These loci appeared only in the progeny of virus-positive females. They segregate with mendelian ratios, are unlinked to markers on chromsome 7 near Akv-1, and are phenotypically expressed as high-virus-inducing loci. The generation of new loci for viurs induction, no doubt resulting from the rare germ-line reintegration of the endogenous ectropic provirus, represents a unique form of gene duplication and rearrangement.
D000406:AKR murine leukemia virus / Q000235:genetics*; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D005814:Genes, Viral; D008040:Genetic Linkage; D009052:Leukemia Virus, Murine / Q000235:genetics*; D051379:Mice; D008806:Mice, Inbred AKR / Q000235:genetics*; D014779:Virus Replication