Effect of ethanol on superoxide dismutase activity in cultured neural cells.
Superoxide dismutase (EC 1.15.1.1) activity was investigated in several types of neural cells cultivated in the presence of 100 mM ethanol. Superoxide dismutase was inhibited by acute treatment with ethanol. Chronic treatment with ethanol specifically inhibited superoxide dismutase in glial cells. In all instances withdrawal of ethanol produced a quick return to control values. Inhibition of superoxide dismutase by ethanol may increase toxic oxygen radicals in nervous tissue.
D000818:Animals; D001921:Brain / Q000196:embryology; D002460:Cell Line; D002472:Cell Transformation, Viral; D002645:Chickens; D000431:Ethanol / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D009457:Neuroglia / Q000201:enzymology; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D013539:Simian virus 40; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors*
D000431:Ethanol; D013482:Superoxide Dismutase