Transformation by Abelson murine leukemia virus: properties of the transformed cells.
Ab-MuLV transforms mouse 3T3 fibroblasts, macrophages, and lymphocytes, which have properties of immature cells in the B-lymphocyte differentiation pathway. Differences in expression of intracellular immunoglobulin and surface antigens the lymphoma lines suggest that more than one B-lymphocyte differentiation stage may be transformed, each of which must be before the B lymphocyte acquires cell-surface immunoglobulin receptors for antigen and antigen sensitivity. The plasmacytomas induced by Ab-MuLV plus pristane tested thus far show no evidence of infection by Ab-MuLV. The transformation of these immunoglobulin-secreting cells may be due to causes other than the transforming elements of the Ab-MuLV genome.
D000011:Abelson murine leukemia virus / Q000276:immunology; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000382:microbiology*; D002454:Cell Differentiation; D002460:Cell Line; D002472:Cell Transformation, Viral; D009052:Leukemia Virus, Murine / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology / Q000473:pathology; D008223:Lymphoma / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D010954:Plasmacytoma / Q000382:microbiology
D000954:Antigens, Surface