title: Cyanides and their toxicity: a literature review.
abstract: Cyanide is a potent and rapidly-acting asphyxiant which prevents tissue utilization of oxygen by inhibition of the cellular respiratory enzyme, cytochrome oxidase. Inhalation or ingestion of cyanide produces reactions within a few seconds and death within minutes. Cyanide toxicity of dietary origin has been implicated in acute animal deaths and as major etiologic factors in toxic ataxic neuropathy in man and as a cause of vision failure in humans suffering from tobacco amblyopia and leber's hereditary optic atrophy. Diagnosis of cyanide toxicity may be confirmed by a variety of laboratory procedures, but accurate assay is essential for proper conclusions from analysis of animal tissues several hours after death or from human samples in instances of chronic dietary exposure. Biological detoxification of cyanide is available through several routes, and the application of sodium nitrite with sodium thiosulfate or administration of methylene blue are effective treatment procedure. The environmental availability of cyanide in its various forms necessitates an understanding of its pathophysiology and responsible management of hazardous situations.
mesh_terms: D000042:Absorption; D000822:Animal Husbandry; D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D003486:Cyanides / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000506:poisoning / Q000633:toxicity*; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors; D004785:Environmental Pollutants; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use; D000860:Hypoxia / Q000139:chemically induced; D008658:Inactivation, Metabolic; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary; D011180:Postmortem Changes; D012977:Sodium Nitrite / Q000627:therapeutic use; D013885:Thiosulfates / Q000627:therapeutic use
chemical_list: D002614:Chelating Agents; D003486:Cyanides; D004785:Environmental Pollutants; D013885:Thiosulfates; D003576:Electron Transport Complex IV; D012977:Sodium Nitrite; D006879:Hydroxocobalamin