A possible role of catecholamines and (Na+ + K+)ATPase in the ethanol withdrawl syndrome.
Chronic ethanol intoxication leads to an increase in the intracellular Na+/K+ ratio. It is suggested that this derangement is counteracted by catecholamines via an activation of (Na+ + K+)ATPase. This hypothesis is discussed in relation to the symptomatology of ethanol withdrawal.
D000320:Adrenergic Fibers / Q000502:physiology; D000437:Alcoholism / Q000378:metabolism / Q000503:physiopathology*; D002395:Catecholamines / Q000502:physiology*; D004789:Enzyme Activation; D006801:Humans; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000503:physiopathology*
D002395:Catecholamines; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium