Lamina-specific alteration of C-fibre evoked activity by morphine in the dorsal horn of the rat spinal cord.
The effect of systemic morphine (5 mg/kg) on the C-fibre evoked activity in the dorsal horn of decerebrate spinalized rats has been investigated. Activity in units recorded from lamina 5 was inhibited in a naloxone-reversible fashion by morphine. However, morphine produced variable changes in the C-evoked activity of units recorded within the substantia gelatinosa, some units showing excitation, some inhibition and some an alteration in the timing and pattern of the C-evoked activity.
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D005727:Ganglia, Spinal / Q000187:drug effects*; D007395:Interneurons / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009412:Nerve Fibers / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects; D013376:Substantia Gelatinosa / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D011957:Receptors, Opioid; D009020:Morphine