Effect of combined GABA-ergic and dopaminergic stimulation on the action of some antiepileptic drugs in pentetrazol-induced convulsions.
Apomorphine (up to 10 mg/kg) and amantadine (up to 100 mg/kg) did not affect pentetrazol-induced convulsions in mice. One of two GABA-ergic agonists tested, baclofen (10 mg/kg), decreased seizure susceptibility (except for the clonic phase) while another, amino-oxyacetic acid (up to 20 mg/kg) had no effect. Combined treatment was most effective in the case of baclofen (5 mg/kg) and amantadine (100 mg/kg) where number of animals with tonic seizures was decreased. Dopaminergic stimulation did not modify the action of some anticonvulsants tested. However, GABA-ergic stimulation resulted in a marked potentiation of the action of carbamazepine (10 mg/kg) and acetazolamide (20 mg/kg), being less pronounced in reference to diazepam (0 . 5 mg/kg) in lefadol (20 mg/kg). On the other hand, combined treatment with GABA-ergic and dopaminergic stimulants was shown to enhance the action of carbamazepine and acetazolamide, but not in the clonic phase. The obtained results suggest effectiveness of GABA-ergic stimulation in the case of all drugs tested and the combined treatment with GABA-ergic and dopaminergic agonists in potentiating the effects of some antiepileptics.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D011963:Receptors, GABA-A; D012640:Seizures / Q000139:chemically induced*
D000927:Anticonvulsants; D011956:Receptors, Cell Surface; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D010433:Pentylenetetrazole