[Effect of cyclic guanosine monophosphate on certain indices of muscle tissue carbohydrate metabolism during the wound process].
The effect of intraperitoneal administration of cGMP (0.5 mg per animal) on carbohydrate metabolism of wound area muscle tissue was studied in experiments on rats with linear skin wounds. The content of glycogen, gluconeogenesis, activity of glycogen phosphorylase, lactate dehydrogenase and malate dehydrogenase were studied. Cyclic GMP induced a substantial activation of glycogen metabolism (elevation of gluconeogenesis, increase in the activity of glycogen phosphorylase) even the third day after the operation. The animals not given cGMP demonstrated such an activation only the fifth day following the operation. Under the effect of cGMP the activity of lactate dehydrogenase rose the third day after the operation. Thus cGMP administration to the animals with wounds leads to an earlier mobilization of energy resources thereby promoting the acceleration of wound healing.
D000818:Animals; D050260:Carbohydrate Metabolism; D006152:Cyclic GMP / Q000494:pharmacology / Q000627:therapeutic use*; D005943:Gluconeogenesis; D006003:Glycogen / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000293:injuries* / Q000378:metabolism; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy*
D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D006005:Phosphorylases; D006152:Cyclic GMP
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