Imaging of experimental myocardial infarction with technetium-99m 2,3-dimercaptosuccinic acid.
We have studied the use of Tc-99m-labeled 2,3-dimercaptosuccinic acid (Tc-99m DMSA) to scintigraph acute myocardial infarction after coronary occlusion in dogs. Optimal images were obtained 5 hr after injection of radiotracer, with consistent delineation 48 hr after occlusion. Delivery of tracer was dependent on blood flow. Uptake of tracer correlated to extent of infarction as determined by the myocardial depletion of creatine kinase. Myocardial Tc-99m DMSA was protein-bound.
D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000150:complications*; D003402:Creatine Kinase / Q000032:analysis; D004285:Dogs; D006207:Half-Life; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D004113:Succimer / Q000378:metabolism; D013438:Sulfhydryl Compounds; D013667:Technetium / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D013438:Sulfhydryl Compounds; D013667:Technetium; D004113:Succimer; D003402:Creatine Kinase