Renal effects of 8-substituted derivatives of adenosine 3',5'-cyclic monophosphate in dogs.
The renal effects of nine, 8-substituted derivatives of 3',5'-cyclic monophosphate were studied in anesthetized mongrel dogs. Infusion of the compounds into a renal artery resulted in an increase of renal blood flow without any effect on blood pressure. Diuretic and natriuretic effects are evident with 6 of the 9 derivatives. As these 8-substituted analogues exert renal effects in a manner similar to that seen with the parent nucleotide, cyclic adenosine 3',5'-monophosphate, they may serve as useful pharmacological agents in vivo.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D000242:Cyclic AMP / Q000031:analogs & derivatives* / Q000494:pharmacology; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000652:urine; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000652:urine; D013329:Structure-Activity Relationship; D014556:Urine
D012964:Sodium; D000242:Cyclic AMP; D011188:Potassium