ACTH in normal children and children with pituitary and adrenal diseases. I. Measurement in plasma by radioimmunoassay--basal values.
Plasma ACTH was measured by radioimmunoassay including preliminary extraction onto adsorbent glass particles. Normal basal values for children 4-16 years of age were 11-82 microgram/ml, corresponding to values found in the literature. Normal values were found in girls with precocious puberty, children with McCune-Albright and Beckwith-Wiedemann's syndrome. Values between 233 and 305 pg/ml were found in untreated children with congenital adrenal hyperplasia. In primary Addison's disease, very high levels (654-1 413 pg/ml) before cortisone therapy and their decline to nearly normal values during therapy are described. ACTH values in a case of pituitary Cushing's syndrome was just above the normal range (104-163 microgram/ml).
D000293:Adolescent; D000307:Adrenal Gland Diseases / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010900:Pituitary Diseases / Q000097:blood*; D011863:Radioimmunoassay; D012016:Reference Values
D000324:Adrenocorticotropic Hormone