title: Paradoxical effect of naloxone on nitrous oxide analgesia in man.
abstract: The effect of naloxone on nitrous oxide analgesia in man has been investigated. The paradoxical response so obtained indicates the possibility of a dural system mediating the pain response in man. These results support previous animal experiments indicating that nitrous oxide analgesia is mediated by the opiate receptors.
mesh_terms: D000328:Adult; D000698:Analgesia; D004347:Drug Interactions; D004357:Drug Synergism; D004723:Endorphins / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009609:Nitrous Oxide / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism
chemical_list: D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D009609:Nitrous Oxide