title: Effects of macrocyclic polyamines and polymethylenediamines on reactions influenced by polyamines.
abstract: The effects of macrocyclic polyamines and polymethylenediamines on various reactions influenced by polyamines have been studied. Among the amines tested, 2,3,4,3- and 3,3,3,4-cyclic polyamines, NH2(CH2)6NH2 and NH2(CH2)8NH2 had some ability to stimulate polyphenylalanine synthesis, globin synthesis and rat liver isoleucyl-tRNA formation. The degree of stimulation was at most 40% of that obtained by polyamines. In the degradation of poly(C) by bovine pancreatic RNAase A, all tested amines stimulated the degradation. In the NADPH-dependent lipid peroxidation of rat liver microsomes, the degree of inhibition by 2,3,2,3- or 2,3,3,3-cyclic polyamine was greater than that by spermine. The hydrolysis of ATP by an oligomycin-sensitive ATPase was inhibited by 2,3,4,3- and 3,3,3,4-cyclic polyamines, NH2(CH2)10HN2 and spermine at somewhat comparable levels. None of the macrocyclic polyamines or polymethylenediamines stimulated the growth of a polyamine-requiring mutant of Escherichia coli. Possible explanations for the differences in the effects of amines on the various reactions are discussed.
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D004720:Endonucleases / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010452:Peptide Biosynthesis; D011073:Polyamines / Q000378:metabolism / Q000494:pharmacology*; D012346:RNA, Transfer, Amino Acyl / Q000096:biosynthesis; D051381:Rats; D012259:Ribonuclease, Pancreatic; D012260:Ribonucleases / Q000378:metabolism
chemical_list: D008054:Lipid Peroxides; D011073:Polyamines; D012346:RNA, Transfer, Amino Acyl; D004720:Endonucleases; D012260:Ribonucleases; D012259:Ribonuclease, Pancreatic; D000251:Adenosine Triphosphatases