VIP-and glucagon-induced formation of cyclic AMP in intact retinae in vitro.
VIP, glucagon or several other neuropeptides were applied to intact retinae in vitro. VIP was found to be a very potent stimulator of cyclic AMP production in rabbit retina, whereas glucagon was efficient in pigeon retina. Attempts to modify the VIP-induced formation of cyclic AMP by somatostatin or dopamine-related drugs (neuroleptics) were not successful. These biochemical data may be correlated to some extent with the recent immunohistochemical localisation of VIP and glucagon in mammalian or avian retinae.
D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005934:Glucagon / Q000494:pharmacology*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D005934:Glucagon; D000242:Cyclic AMP