Akvr-1, a dominant murine leukemia virus restriction gene, is polymorphic in leukemia-prone wild mice.
We describe a restriction gene (Akvr-1, for AKR virus restriction) that is polymorphic for two alleles, Akvr-1R (restrictive) and Akvr-1r (susceptible), in a feral population of mice (Mus) musculus domesticus) at a squab farm near Lake Casitas (LC) in southern California. Akvr-1k is a dominant allele that exhibits 100% penetrance in prevention of viremia of AKR endogenous retrovirus and of virus-mediated lymphoma in LC (Akvr-1RR) X AKR F1 hybrids. The restriction phenotype segregates as a single Mendelian locus in backcrosses to AKR mice. Akvr-1R likewise is effective in restriction of NB-tropic Moloney murine leukemia virus-induced viremia and NB-tropic Friend virus-induced splenomegaly but fails to restrict expression or pathogenesis of LC-derived amphotropic retrovirus. Pleiotropic restriction of AKR, Friend, and Moloney ecotropic viruses, but not of amphotropic virus, suggests that the viral targets of Akvr-1 in the three ecotropic viruses are similar to each other and distinct from the target in the LC-amphotropic virus. The relationship of Akvr-1 to previously reported murine restriction loci Fv-1, Fv-2, and Fv-4 is discussed.
D000406:AKR murine leukemia virus / Q000235:genetics; D000818:Animals; D000835:Animals, Wild / Q000235:genetics / Q000382:microbiology; D005799:Genes, Dominant; D005809:Genes, Regulator; D007113:Immunity, Innate; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics / Q000382:microbiology; D051379:Mice / Q000235:genetics / Q000382:microbiology*; D011110:Polymorphism, Genetic; D014779:Virus Replication