[Effect of adenosine cyclic monophosphate on insulin secretion in healthy rats and in those with alloxan diabetes].
Studies on rats and dogs demonstrated exogenous cAMP to aid elevation of the blood insulin level in healthy animals and, to a lesser extent, in the animals with a mild course of diabetes mellitus caused by alloxan damage of beta-cells. In case of a severe course of diabetes mellitus exogenous cAMP produced no stimulating action on the insulin secretion.
D000496:Alloxan; D000818:Animals; D000941:Antigens; D001786:Blood Glucose / Q000032:analysis; D000242:Cyclic AMP / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004285:Dogs; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D000941:Antigens; D001786:Blood Glucose; D007328:Insulin; D000496:Alloxan; D000242:Cyclic AMP
Vliianie 3',5'-adenozinmonofosfata na sekretsiiu insulina u zdorovykh zhivotnykh i u zhivotnykh s alloksanovym diabetom.