Inhibition of hypersensitivity reactions by 16(S)-methyl-20-methoxy-PGE2 (YPG-209) in animals.
The effects of 16(S)-methyl-20-methoxy-PGE2 (YPG-209) on hypersensitivity reactions were investigated in the rat, guinea-pig and mouse. Intravenously administered YPG-209 was 150 times as potent as disodium cromoglycate (DSCG) in the inhibitory effect on the IgE(mouse)-mediated 24 hr rat PCA. When administered intravenously to guinea-pigs, YPG-209 inhibited significantly the IgE (guinea-pig)-mediated 8 day guinea-pig PCA, whereas DSCG exhibited no significant inhibitory effects. The oral doses of YPG-209 diminished both histamine and 5-hydroxytryptamine hypersensitivity of the Bordetella pertussis-treated mice. These results suggest that YPG-209 exhibits not only the prevention of mediator release but also the antimediator effect in laboratory animals.
D000818:Animals; D001886:Bordetella pertussis / Q000276:immunology; D015232:Dinoprostone / Q000031:analogs & derivatives*; D004342:Drug Hypersensitivity / Q000517:prevention & control; D005260:Female; D006632:Histamine / Q000494:pharmacology / Q000633:toxicity; D006967:Hypersensitivity / Q000517:prevention & control*; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology
D011459:Prostaglandins E, Synthetic; D012701:Serotonin; C026720:16-methyl-20-methoxy-PGE2; D006632:Histamine; D015232:Dinoprostone