Trophic effect of cholecystokinin-octapeptide in man - a new way in the treatment of chronic pancreatitis?
The effect of 3-week CCK-OP treatment on test meal stimulated pancreatic secretion was investigated in chronic pancreatitis patients. One drop of a 1 mg/ml CCK-OP solution applied intranasally, three times daily during 3 weeks resulted in a significant increase in volume, trypsin, lipase and amylase secretion in response to the Lundh test meal. Augmentation of trypsin secretion was the most pronounced. Functional capacity of pancreatic enzyme secretion remained elevated for 3 months after treatment. Nearly all patients became symptom free during and for some time after treatment. The results were attributed to a trophic effect of CCK-OP on human pancreas.
D000281:Administration, Intranasal; D000328:Adult; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002908:Chronic Disease; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D010195:Pancreatitis / Q000188:drug therapy*; D012844:Sincalide
D002766:Cholecystokinin; D012844:Sincalide