Synthesis and radioreceptor binding activity of turkey beta-endorphin and deacetylated salmon endorphin.
Des-acetylated salmon endorphin and turkey beta-endorphin have been synthesized by the solid-phase method. Relative opiate activities in a radioreceptor binding assay are: human beta-endorphin, 100; des-acetylated salmon endorphin, 169; turkey beta-endorphin, 94. Thus, non-mammalian endorphins can show high activity in a mammalian assay system.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D004723:Endorphins / Q000032:analysis / Q000138:chemical synthesis*; D006801:Humans; D011869:Radioligand Assay; D011957:Receptors, Opioid / Q000032:analysis; D012474:Salmon; D014422:Turkeys; D001615:beta-Endorphin
D000596:Amino Acids; D004723:Endorphins; D011957:Receptors, Opioid; D001615:beta-Endorphin