title: A survey of non-specific cross-protective immunities induced by avian retroviruses.
abstract: Reticuloendotheliosis virus strain T (REV-T) induced immunity in chicks to challenge by representative subgroup members of the avian leukosis-sarcoma virus (ALSV) complex. Immunity levels were compared to determine the extent of antigenic relation between REV-T and the ALSV complex. Reciprocal studies using ALSV subgroup members and pheasant viruses as immunogens and REV-T as challenge were also performed. It was concluded that reciprocity of immunity is not equal between the viruses studied, nor is immunity directly related to the virus-neutralizing-antibody levels induced by immunization with the viruses studied. In some cases, the levels of cross-protection demonstrated may be a sign of the induction of antibodies to common or similar tumor-specific surface antigens rather than complete antigenic identity between REV-T and the ALSV members used; in others, virus-neutralizing antibodies may be a sign of partial identity between some proteins of REV-T and ALSV subgroup members.
mesh_terms: D001355:Alpharetrovirus / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001353:Avian Leukosis / Q000517:prevention & control; D001358:Avian Sarcoma Viruses / Q000276:immunology; D002645:Chickens / Q000276:immunology; D003429:Cross Reactions; D009500:Neutralization Tests; D011201:Poultry Diseases / Q000517:prevention & control; D001356:Reticuloendotheliosis virus / Q000276:immunology; D055761:Reticuloendotheliosis, Avian / Q000517:prevention & control / Q000662:veterinary; D012190:Retroviridae / Q000276:immunology*; D001357:Sarcoma, Avian / Q000517:prevention & control / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral