title: Human relevance: epidemiology and occupational exposure.
abstract: This paper reviews briefly some industrial applications which may result in occupational exposure of the workforce to preformed N-nitroso compounds. It considers exposure to nitrate in more detail, discussing epidemiological evidence which lends support to the hypothesis that high nitrate ingestion is related  to high mortality from gastric cancer, through the formation in vivo of carcinogenic N-nitroso compounds. It presents the preliminary findings in a census-based mortality study of industrial workers exposed to nitrate-containing dust in the manufacture of fertilizers.
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D005308:Fertilizers / Q000633:toxicity; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000139:chemically induced* / Q000401:mortality; D009566:Nitrates / Q000633:toxicity; D009603:Nitroso Compounds / Q000633:toxicity*; D009784:Occupational Diseases / Q000139:chemically induced*
chemical_list: D005308:Fertilizers; D009566:Nitrates; D009603:Nitroso Compounds