[Determination of leukocyte sensitization to tumor and embryonic tissue antigens in cancer of the large intestine].
Aqueous-saline extracts of autologous rectal tumor tissue inhibited leukocyte migration in 7 out of 10 patients with rectal tumors in autoplasm-containing medium, and in 5 out of 11 patients-in control serum. Antigens of allogenic rectal tumors inhibited leukocyte migration (LMI) in 4 out of 5 patients (stage II), in 15 out of 21 patients (stage III), and in 5 out of 10 patients (stage IV) in control serum medium, and in non of control patients. Leukocyte sensitization to mucosal antigen was established only in 8% of patients (stage II-IV), in control serum medium. LMI in medium containing autoplasm and control serum was observed in 24 out of 36 patients. Extracts obtained from human embryonal liver inhibited leukocyte migration in 14 out of 27 patients (stage II-IV), including 3 cases in which leukocytes did not respond to tumor-associated antigen. LMI by carcinoembryonic antigen was registered in a total of 31 out of 36 cases (86%). In 5 cases out of 7, unresponsive leukocytes of patients with rectal tumors did respond to tumor-associated antigen by inhibiting leukocyte migration, after re-incubation at low temperature, in a medium free from autologous blood plasma.
D000230:Adenocarcinoma / Q000276:immunology; D002288:Adenocarcinoma, Mucinous / Q000276:immunology; D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D002464:Cell Migration Inhibition; D006801:Humans; D007114:Immunization; D007414:Intestinal Neoplasms / Q000276:immunology*; D007420:Intestine, Large / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008099:Liver / Q000196:embryology / Q000276:immunology*; D008875:Middle Aged
D000941:Antigens; D000951:Antigens, Neoplasm
Opredelenie sensibilizatsii leĭkotsitov k antigennam opukholeĭ i émbrional'nykh tkaneĭ pri rake tolstoĭ kishki.