Cefazolin experimental epilepsy: the effects of diazepam on the interictal ECoG.
Diazepam i.v. injected at the dose of 5 mg/Kg on a group of 14 Rhode-Island-Red chicks was able to antagonize and prevent the interictal EEG pattern induced by cefazolin i.v. Since cefazolin epilepsy is most probably dependent on a receptorial antagonism with GABA, these data seem to confirm the GABA-ergic nature of cefazolin epilepsy.
D000818:Animals; D002437:Cefazolin / Q000037:antagonists & inhibitors*; D002645:Chickens; D003975:Diazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D004569:Electroencephalography; D007275:Injections, Intravenous; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D017981:Receptors, Neurotransmitter; D005680:gamma-Aminobutyric Acid; D002437:Cefazolin; D003975:Diazepam