Voltage-dependent translocation of the asialoglycoprotein receptor across lipid membranes.
A membrane receptor protein for asialoglycoproteins induces voltage-dependent increases in ion conductance across a lipid bilayer, probably reflecting penetration of the protein into the bilayer towards an electrically positive pole. In the presence of specific ligand for the receptor, this penetration leads to a 'translocation' of the receptor from one side of the bilayer to the other. These observations suggest a mechanism by which biological membranes might regulate the disposition of their proteins, and a way in which membrane receptors involved in endocytosis might be spared lysosomal destruction in order to be recycled to the plasma membrane.
D000818:Animals; D037263:Asialoglycoprotein Receptor; D001692:Biological Transport; D002118:Calcium / Q000502:physiology; D004553:Electric Conductivity; D004705:Endocytosis; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008563:Membrane Lipids; D008564:Membrane Potentials; D008565:Membrane Proteins / Q000378:metabolism*; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000378:metabolism*
D037263:Asialoglycoprotein Receptor; D008024:Ligands; D008563:Membrane Lipids; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D002118:Calcium