The role of extracellular DNA in the transfer of information from T to B human lymphocytes in the course of an immune response.
Human lymphocytes obtained from donors exhibiting different allotypes were separated into B- and T-enriched subpopulations and cultured in the presence or absence of Herpes simplex virus inactivated by U.V. Isolated B or T cell suspensions did not produce any antiherpetic activity. The B lymphocytes cultured in the presence of the supernatant collected from virus-exposed T cells or in the presence of DNA extracted from this supernatant, synthesized an antiherpetic antibody carrying allotypic markers of the T cell donor.
D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D005110:Extracellular Space / Q000276:immunology*; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014165:Transfer Factor / Q000276:immunology
D007126:Immunoglobulin Allotypes; D014165:Transfer Factor; D004247:DNA