title: Intraarterial cis-platinum for patients with inoperable skeletal tumors.
abstract: Twenty-three patients with inoperable skeletal tumors were treated with intraarterial cis-platinum prior to attempted surgery. The antitumor effect of intraarterial cis-platinum was monitored clinically by radiologic imaging techniques, and whenever possible, evaluated histopathologically by examinatin of surgical or biopsy tumor specimens. Objective responses were noted in 12 patients (52%) and included 2 complete, 7 partial and 3 less-than-partial remissions lasting from 14 to 70 weeks. Limb-saving surgery or hemipelvectomy became subsequently feasible in four and one patients respectively. Preoperative intraarterial cis-platinum is a safe procedure which might be used effectively in combination with other, more conventioal postoperative adjuvant chemotherapy against skeletal tumors.
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy*; D002813:Chondrosarcoma / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D005260:Female; D005870:Giant Cell Tumors / Q000188:drug therapy; D018219:Histiocytoma, Benign Fibrous / Q000188:drug therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy; D012075:Remission, Spontaneous
chemical_list: D002945:Cisplatin