alpha 2-Adrenergic receptors are associated with renal proximal tubules.
The location of alpha 2-adrenergic receptors has been investigated in the guinea pig kidney. We used an in vitro labeling autoradiographic technique to examine the distribution of specific [3H]clonidine binding sites with the light microscope. alpha 2-Adrenergic receptors appeared to be located predominantly on the proximal tubules. The implication of this finding for renal physiology is discussed.
D000818:Animals; D001345:Autoradiography; D003000:Clonidine / Q000378:metabolism; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008297:Male; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D014018:Tissue Distribution
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D003000:Clonidine