[Effect of acetylcholine on cyclic guanosine monophosphate levels in the hearts of rats of different ages].
The effect of various doses of acetylcholine on the content of myocardial cGMP was studied in rats of different age. The degree of changes was shown to depend on acetylcholine dosage and animals' age. Low doses produced more potent effect in adult rats. It is suggested that these features of alteration of cGMP content may be a reason for increased myocardial sensitivity to acetylcholine in old age.
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D000367:Age Factors; D000818:Animals; D006152:Cyclic GMP / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000502:physiology; D066298:In Vitro Techniques; D009206:Myocardium / Q000032:analysis*; D009388:Neostigmine / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects
D011950:Receptors, Cholinergic; D009388:Neostigmine; D006152:Cyclic GMP; D000109:Acetylcholine
Vliianie atsetilkholina na uroven' tsiklicheskogo guanozinmonofosfata v serdtse krys raznogo vozrasta.