title: Some spiro analogues of the potent analgesic ketobemidone.
abstract: A series of spiro analogues of the potent narcotic ketobemidone have been prepared and found to be devoid of opiate activity. Additional pharmacology and possible implications for the mode of binding of ketobemidone to the analgesic receptor are discussed.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D000882:Haplorhini; D008614:Meperidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D011957:Receptors, Opioid; D013141:Spiro Compounds; D008614:Meperidine; C012394:ketobemidone