title: [Plans for using vaccination in Aujeszky's disease].
abstract: A number of clinical, serological, virological and pathomorphological investigations were carried out on pigs bred on a swine-breeding farm, enzootic with regard to AD. One hundred and forty pigs, born by mothers vaccinated with ethanol-saponin vaccine, were inoculated with different quantities of living MK-25 vaccine against AD at the moment of their weaning, as well as on the 15th, 90th and 150th days after the vaccination, were nasally infected in doses 4 cm3 with a virulent/5 x 10(6) CCIU in 1 cm3/virus. No encephalitic clinical symptoms were observed but pathomorphologically was proved a non-suppurative meningoencephalitis with the 1 dose vaccinated pigs, provoked on the 15th day after the vaccination, with those pigs used for control and vaccinated with 1 dose on 90th day and with one control pig on the 180th day. We also proved the presence of lymphohistiocyte interstitial pneumonia as well as intranuclear inclusions in the macrophages of the tonsils. A virus was isolated from the tonsils and from the lungs. Serologically was proved an increase in the titre of antibodies with all test pigs. It was proved that the passively acquired (colostrum) immunity against AD which the pigs, born by vaccinated mothers, possess neutralized the vaccinal virus and prevented the acquisition of an active immunity after vaccination. Its inhibitory action could be overcome by vaccinating with increased quantities of vaccine.
mesh_terms: D000818:Animals; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007110:Immunity, Active; D007112:Immunity, Maternally-Acquired; D011557:Pseudorabies / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D013997:Time Factors; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D014765:Viral Vaccines
vernacular_title: Skhemi za prilozhenie na vaksinatsiia pri bolestta n a Aueski.