Persistent paramyxovirus infections and behaviour of beta-adrenergic receptors in C-6 rat glioma cells.
This paper describes the influence of persistent infections of C-6 rat glioma cells by paramyxoviruses [virus of subacute sclerosing panencephalitis (SSPE) and canine distemper (CDV)] on the cellular beta-adrenergic membrane receptors. The number and binding properties of the beta-adrenergic receptors of the paramyxovirus-infected cells were measured by 3H-dihydroalprenolol binding studies and compared with those of the uninfected C-6 cells. In the case of SSPE virus neither changes in number nor binding properties of beta-adrenergic receptors could be observed, whereas in the case of CDV persistence the number of beta-adrenergic receptors was reduced to about 50%, without an apparent influence on the binding constant for the ligand to the receptors.
D000818:Animals; D002460:Cell Line; D004082:Dihydroalprenolol / Q000378:metabolism; D004217:Distemper Virus, Canine / Q000502:physiology*; D005910:Glioma; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000378:metabolism*; D013190:SSPE Virus / Q000502:physiology*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol