title: [Comparative study of atracurium and alcuronium for the intubation of older patients in halothane anesthesia].
abstract: Intubation conditions, onset time (time from the end of the injection until the maximum twitch depression (1 Hz) of the adductor pollicis muscle) as well as changes in blood pressure and pulse rate were studied in a randomized double-blind study of 40 male patients (average age 69-70 years) anaesthetized with halothane following atracurium (ATR) 0.33 mg X kg-1 or alcuronium (DAN) 0.1 mg X kg-1. An additional group received succinylcholine (SCH) 1.0 mg X kg-1. Intubation conditions at the end of the onset time were slightly and significantly better after ATR than following DAN, in each case, however, distinctly worse than after SCH. The onset time amounted to 115.0 s after ATR and 125.0 s following DAN (48.6 s after SCH). Neither ATR nor DAN showed statistically significant effects on blood pressure or pulse. One bronchospastic reaction which responded to therapy was observed per group. ATR proved to be comparable to DAN in respect to effectiveness and safety.
mesh_terms: D000368:Aged; D000443:Alcuronium / Q000009:adverse effects; D000769:Anesthesia, Inhalation; D001279:Atracurium; D001794:Blood Pressure / Q000187:drug effects; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D007546:Isoquinolines / Q000009:adverse effects; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects; D011229:Preanesthetic Medication; D014117:Toxiferine / Q000031:analogs & derivatives
chemical_list: D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D014117:Toxiferine; D000443:Alcuronium; D006221:Halothane
vernacular_title: Vergleichende Untersuchung von Atracurium und Alcuronium zur Intubation älterer Patienten in Halothannarkose.