ACTH LPH and related peptides in the ectopic ACTH syndrome.
Adrenocorticotrophin, lipotrophin and the related peptides alpha-MSH, CLIP, beta-endorphin and met-enkephalin have been measured, and characterized chromatographically in tumour extracts from seven patients with the ectopic ACTH syndrome. Four of the seven tumours contained the complete family of peptides, although the proportion of one to another varied between tumours. In addition, large molecule weight forms of ACTH and met-enkephalin were seen. The potential clinical importance of these observations is discussed.
D000182:ACTH Syndrome, Ectopic / Q000032:analysis*; D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D002850:Chromatography, Gel; D053497:Corticotropin-Like Intermediate Lobe Peptide; D004723:Endorphins / Q000032:analysis; D004745:Enkephalins / Q000032:analysis; D006801:Humans; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D009384:Paraneoplastic Endocrine Syndromes / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis; D008083:beta-Lipotropin / Q000032:analysis*
D004723:Endorphins; D004745:Enkephalins; D010446:Peptide Fragments; D053497:Corticotropin-Like Intermediate Lobe Peptide; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin