Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains.
A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction.
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D005814:Genes, Viral; D005819:Genetic Markers; D006822:Hybrid Cells / Q000166:cytology; D007065:Idoxuridine / Q000494:pharmacology; D007621:Karyotyping; D009052:Leukemia Virus, Murine / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D011995:Recombination, Genetic; D014775:Virus Activation
D005819:Genetic Markers; D007065:Idoxuridine