[The activity of imidazole derivatives in the presence of human plasma (author's transl)].
By Warburg technique using yeasts and staphylococci, any decrease in antimicrobial activity of the imidazole derivatives could be excluded in the presence of human plasma. Econazole nitrate, the classical topical imidazole derivative, and ketoconazole, an oral active antifungal, were tested. The compatibility between imidazole derivatives and human plasma is of practical importance for obtaining optimal therapeutic results in treating human mycoses.
D000935:Antifungal Agents; D002176:Candida albicans / Q000187:drug effects; D003881:Dermatomycoses / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004464:Econazole / Q000097:blood; D006801:Humans; D007093:Imidazoles / Q000097:blood* / Q000627:therapeutic use; D007654:Ketoconazole; D010101:Oxygen Consumption / Q000187:drug effects; D010879:Piperazines / Q000097:blood; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects
D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D004464:Econazole; D007654:Ketoconazole
Die Aktivität von Imidazol-Antimyzetika in Anwesenheit von Humanplasma.