Feline uveal melanoma model induced with feline sarcoma virus.
This paper described the first animal model of a virally induced uveal melanoma. Tumors developed following the injection of an RNA tumor virus, i.e., Gardner strain feline sarcoma virus, into the anterior chamber of newborn kittens. Histologically, the tumors were found to be iris and ciliary body melanomas, many of which showed invasion. The histology and ultrastructure of those tumors are described.
D000818:Animals; D002415:Cats; D002924:Ciliary Body / Q000473:pathology; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D007498:Iris / Q000473:pathology; D008545:Melanoma / Q000473:pathology* / Q000648:ultrastructure; D009361:Neoplasm Invasiveness; D012160:Retina / Q000473:pathology; D005253:Sarcoma Viruses, Feline; D012590:Sclera / Q000473:pathology; D014412:Tumor Virus Infections / Q000473:pathology* / Q000648:ultrastructure; D014604:Uveal Neoplasms / Q000473:pathology* / Q000648:ultrastructure