Stimulation of pyruvate carboxylation by gastric secretagogues.
Pyruvate carboxylation was stimulated by 2 gastric secretagogues, histamine and dibutyryl cyclic AMP, and by butyrate. Thiocyanate, an inhibitor of acid secretion, produced a slight decrease. Avidin significantly reduced acid secretion and this effect was overcome by biotin and oxalacetate. The results suggest that carboxylation of pyruvate is one of the reactions controlling oxidative metabolism and acid secretion in toad gastric mucosa.
D000818:Animals; D001360:Avidin / Q000494:pharmacology; D001710:Biotin / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology; D002024:Bufo marinus; D002087:Butyrates / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D011773:Pyruvates / Q000378:metabolism*; D013861:Thiocyanates / Q000494:pharmacology
D002087:Butyrates; D011773:Pyruvates; D013861:Thiocyanates; D001360:Avidin; D003994:Bucladesine; D001710:Biotin; D006632:Histamine