Effect of prolactin on phospholipid biosynthesis by alveolar cell carcinoma (A549) in monolayer tissue culture.
By means of an alveolar cell carcinoma (A549) model, the effect of prolactin on pulmonary surfactant phospholipid biosynthesis was investigated. Preliminary results suggest that phosphatidylcholine synthesis via the phosphatidic acid phosphohydrolase pathway in addition to phosphatidylglycerol may be stimulated by the presence of prolactin.
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000378:metabolism*; D046508:Culture Techniques; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D010715:Phosphatidylglycerols / Q000096:biosynthesis; D010743:Phospholipids / Q000096:biosynthesis*; D011388:Prolactin / Q000494:pharmacology*; D011663:Pulmonary Surfactants / Q000096:biosynthesis
D010715:Phosphatidylglycerols; D010743:Phospholipids; D011663:Pulmonary Surfactants; D011388:Prolactin