The laser Doppler: a non-invasive measure of cochlear blood flow.
The present investigation demonstrates the utility of the laser Doppler flowmeter to provide a measure of cochlear blood flow dynamics. Cochlear and cutaneous blood flow were compared with arterial blood pressure during and following exposure to Angiotensin II, 5% carbon monoxide, 100% oxygen, mannitol, and saline. The observations indicate that: 1) cochlear blood flow generally parallels cutaneous blood flow; however, 2) when cutaneous beds vasoconstrict (e.g., AII, alpha-agonists), cochlear blood flow parallels blood pressure; and, 3) under the influence of agents that affect peripheral and central circulation (5% CO, 100% O2), cochlear blood flow may dissociate from cutaneous blood flow and blood pressure. The implications of these findings are discussed in terms of local control mechanisms that may be involved in the inner ear vasculature.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002248:Carbon Monoxide / Q000494:pharmacology; D003051:Cochlea / Q000098:blood supply*; D006168:Guinea Pigs; D008353:Mannitol / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects*; D012212:Rheology; D012867:Skin / Q000098:blood supply; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D008353:Mannitol; D002248:Carbon Monoxide; D010100:Oxygen