Perinatal exposure to cannabichromene and delta 9-tetrahydrocannabinol: separate and combined effects on viability of pups and on male reproductive system at maturity.
The effects of cannabichromene (CBC), delta 9-tetrahydrocannabinol (delta 9-THC) and their combination (all doses 50 mg/kg orally) were determined after being administered to female mice for 7 days beginning on the 20th day of gestation. The THC treatment reduced postnatal viability, impaired male reproductive behavior at maturity and significantly reduced seminal vesicle weights. No changes from control values occurred after CBC or CBC + THC. Thus, CBC alone at this dosage did not act like THC; moreover, it antagonized the effects of THC when the two were given in combination.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D002186:Cannabinoids / Q000633:toxicity*; D013759:Dronabinol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D051379:Mice; D011247:Pregnancy
D000893:Anti-Inflammatory Agents; D002186:Cannabinoids; D013759:Dronabinol; C010695:cannabichromene