Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy.
In a 78-year-old woman receiving perhexiline maleate for intractable angina pectoris, a syndrome of parkinsonism and peripheral neuropathy developed. The neuropathy was confirmed by electromyographic and nerve conduction studies. The parkinsonism and peripheral neuropathy disappeared when perhexiline maleate was discontinued.
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D005260:Female; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D010480:Perhexiline / Q000009:adverse effects* / Q000031:analogs & derivatives; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D010880:Piperidines / Q000009:adverse effects*
D010880:Piperidines; C023470:perhexiline maleate; D010480:Perhexiline