Effect of dopaminergic and GABA-ergic drugs given alone or in combination on the anticonvulsant action of phenobarbital and diphenylhydantoin in the electroshock test in mice.
In the electroshock test--taking hind-limb tonic extension as the end point--apomorphine (10 mg/kg) exerted no effect on the anticonvulsant action of phenobarbital (PB; 20 mg/kg) or diphenylhydantoin (DPH; 8 mg/kg); amantadine (25 and 100 mg/kg) decreased that of DPH, while L-DOPA (500 mg/kg) and d,l-amphetamine (10 mg/kg) potentiated the action of both anticonvulsants. Fluphenazine (4 mg/kg) had no influence on the effects of the two anticonvulsants, but haloperidol lessened that of DPH. All GABA-ergic stimulants used, i.e., gamma-hydroxybutyric acid (GHBA/250 mg/kg), baclofen (2.5 and 10 mg/kg) and aminooxoacetic acid (AOAA; 15 and 20 mg/kg) potentiated the action of PB; the action of DHP was unaffected by these drugs except for AOAA (20 mg/kg). The combined treatment with dopaminergic and GABA-ergic stimulants, being ineffective in terms of anticonvulsant activity, resulted in a marked potentiation of the action of the anticonvulsants tested in this study. The most distinct potentiation was noted in the case of PB, baclofen (1 mg/kg), and amantadine (25 mg/kg).
D000547:Amantadine / Q000494:pharmacology; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001418:Baclofen / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D004597:Electroshock; D005260:Female; D005476:Fluphenazine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006885:Hydroxybutyrates / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D012640:Seizures / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D006885:Hydroxybutyrates; D017981:Receptors, Neurotransmitter; D000625:Aminooxyacetic Acid; D007980:Levodopa; D005680:gamma-Aminobutyric Acid; D010672:Phenytoin; D000547:Amantadine; D000661:Amphetamine; D001418:Baclofen; D006220:Haloperidol; D001058:Apomorphine; D005476:Fluphenazine; D004298:Dopamine; D010634:Phenobarbital