Clinical trial of concentrated inactivated polio vaccine in a simplified immunization program.
The aims of the trial were: 1) to verify the effectiveness of injectable polio vaccine (inactivated) combined with concentrated diphtheria and tetanus toxoid, in one or two injections given at an interval of 6 months; 2) to compare the killed polio vaccine with the oral vaccine which is recommended in the Ivory Coast program: 4 doses in 15 months. The effectiveness of the immunizations is judged by the serum antibody levels 8 to 12 weeks following immunization. The comparative study of 2 inactivated polio vaccines A and C with live oral vaccine showed the superiority of inactivated vaccine, which resulted in good seroconversion after a single dose. The increase in the serologic response is proportional to the antigenic mass since it appears that the concentration of vaccine C is double that of A.
D002986:Clinical Trials as Topic; D007560:Cote d'Ivoire; D004168:Diphtheria Toxoid / Q000008:administration & dosage; D006801:Humans; D007114:Immunization; D007223:Infant; D010567:Pertussis Vaccine / Q000008:administration & dosage; D011051:Poliomyelitis / Q000517:prevention & control; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage*; D013745:Tetanus Toxoid / Q000008:administration & dosage; D014613:Vaccines, Attenuated
D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral; D013745:Tetanus Toxoid; D014613:Vaccines, Attenuated