Molecular interactions in biomedicine: modulation of regulatory behavior by cross reactivity: relevance to analysis of receptor function.
The influence of cross reactivity on biomolecular regulation is not frequently incorporated into theoretical analysis and is often eliminated by experimental design. Nonetheless, cross reactive molecules produce effects on binding which may considerably modulate their behavior in quite diverse systems, i.e., drug-tissue receptor, antigen-antibody, substrate-enzyme, protein-DNA and hormone-tumor receptor interactions. In particular, certain effects vary at different concentrations suggesting a simple control mechanism.
D000494:Allosteric Regulation; D001665:Binding Sites; D008024:Ligands; D046911:Macromolecular Substances; D008954:Models, Biological; D011956:Receptors, Cell Surface; D011955:Receptors, Drug; D011987:Receptors, Steroid
D008024:Ligands; D046911:Macromolecular Substances; D011956:Receptors, Cell Surface; D011955:Receptors, Drug; D011987:Receptors, Steroid