Rearrangement of chloramphenicol-3-monosuccinate.
The equilibrium mixture of chloramphenicol-3-monosuccinate and its alternate form at neutral pH in aqueous solution was reexamined. The structure of the alternate form was shown by mass specxtrometry and NMR spectroscopy to be chloramphenicol-1-monosuccinate and not the cyclic hemi-ortho ester reported previously.
D055598:Chemical Phenomena; D002621:Chemistry; D002701:Chloramphenicol / Q000031:analogs & derivatives*; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D011522:Protons
D011522:Protons; D002701:Chloramphenicol; C026016:chloramphenicol succinate