title: Histological examination for Z-gene alpha 1-antitrypsin deficiency in small cell anaplastic carcinoma of the lung.
abstract: Carriers of Z-gene alpha 1-antitrypsin deficiency (A-1-ATD) have characteristic periodic acid Schiff (PAS) positive diastase resistant globules in hepatocytes. In order to determine a possible relationship between Z-gene A-1-ATD and small cell carcinoma of the lung (SCCL), we examined liver blocks from 88 consecutive autopsies performed on patients with SCCL and from a control group of 88 patients with carcinoma not primarily located in the lung or the liver. Histological evidence of Z-gene-A-1-ATD was 4.5% in both groups, corresponding to the expected frequency of Z-gene carriers in a Scandinavian population. It is therefore unlikely that Z-gene A-1-ATD has a role in the development of SCCL.
mesh_terms: D000328:Adult; D000368:Aged; D018288:Carcinoma, Small Cell / Q000235:genetics*; D005260:Female; D005796:Genes; D006801:Humans; D008099:Liver / Q000473:pathology; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D000515:alpha 1-Antitrypsin / Q000235:genetics*; D019896:alpha 1-Antitrypsin Deficiency
chemical_list: D000515:alpha 1-Antitrypsin