title: Noradrenalin, serotonin, and the dorsal horn.
abstract: There is anatomical, pharmacological, and physiological evidence that descending systems from the brain stem using noradrenalin and serotonin (5-hydroxytryptamine, 5-HT) participate in the control of segmental sensory processing. Study of these systems is described in this paper. L-dopa was given intravenously to cats to cause the release of noradrenalin and 5-HT. The resultant effects on the responses of dorsal horn cells to innocuous and noxious thermal stimulation of skin were determined. Using the catecholamine cell neurotoxin, 6-hydroxydopamine, the dopamine beta-hydroxylase inhibitor, fusaric acid, and the tryptophan hydroxylase inhibitor, parachlorophenylalanine, the available central stores of noradrenalin or 5-HT were altered, thus allowing separation of the effects of noradrenalin and 5-HT release on dorsal horn cells. The results indicate that noradrenalin facilitates the responses of dorsal horn cells to innocuous cutaneous stimuli, and has an inhibitory effect on the responses to noxious stimuli. Serotonin inhibits the responses of dorsal horn cells that respond to noxious stimuli, to both innocuous and noxious stimuli. The results are discussed in light of current developments concerning aminergic control of segmental sensory processing.
mesh_terms: D000818:Animals; D002415:Cats; D010134:Fenclonine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007980:Levodopa / Q000378:metabolism / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D010812:Physical Stimulation; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000378:metabolism* / Q000601:surgery; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D006892:Hydroxydopamines; D012702:Serotonin Antagonists; D012701:Serotonin; D007980:Levodopa; D010134:Fenclonine; D009638:Norepinephrine