Simian virus 40-Chinese hamster kidney cell interaction. V. Cooperative effect of 5-iodo-2'-deoxyuridine and mitomycin C in the enhancement of virus replication in infected cells.
A cooperative effect of 5-iodo-2'-deoxyuridine and mitomycin C which amplified (10- to 50-fold) their stimulating effect on simian virus 40 replication was obtained in infected Chinese hamster kidney cells. The results indicate that these drugs act at different levels to modify the permissiveness of cells to simian virus 40.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007065:Idoxuridine / Q000494:pharmacology*; D007668:Kidney; D008937:Mitomycins / Q000494:pharmacology*; D013539:Simian virus 40 / Q000254:growth & development*; D013268:Stimulation, Chemical; D014779:Virus Replication / Q000187:drug effects*
D008937:Mitomycins; D007065:Idoxuridine