Hemorrhagic syndrome induced in chicken embryos by intravenous inoculation of ground chicken embryo extract.
The hemorrhagic syndrome which occurred after the IV inoculation of ground embryo extract into living chicken embryos resulted from rapid activation and depletion of the clotting mechanism. The syndrome was prevented by the addition of heparin to the ground embryo inoculum. The characteristics of the hemorrhagic syndrome suggest that the phenomenon is the result of disseminated intravascular coagulation.
D000818:Animals; D001820:Bluetongue virus / Q000302:isolation & purification; D002642:Chick Embryo; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006493:Heparin / Q000494:pharmacology
D006493:Heparin