[Experimental studies on administration method of chemotherapeutic agents. 16. Effect of polymyxin B against Pseudomonas aeruginosa (author's transl)].
The most effective administration method of polymyxin B (PL-B), a peptide antibiotic, has been studied in the experimental mice infection with Pseudomonas aeruginosa. 1) Pseudomonas aeruginosa damaged by PL-B, when the drug was free, immediately began to regrow in vitro. 2) the therapeutic efficacy of PL-B on multiple administration was less effective than its single administration. 3) An important factor to decide the therapeutic efficacy of PL-B was the high drug concentration in plasma and peritoneal fluid.
D000818:Animals; D004352:Drug Resistance, Microbial; D008297:Male; D008722:Methods; D051379:Mice; D010529:Peritoneal Cavity / Q000382:microbiology; D011112:Polymyxin B / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011113:Polymyxins / Q000494:pharmacology*; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D011113:Polymyxins; D011112:Polymyxin B