Effect of ACTH administration on the haemodynamic response to arginine-vasopressin in sheep.
1. Blood pressure, heart rate and cardiac output were studies in intace conscious sheep during AVP infusion at 0.1, 0.25, 0.5 and 1.0 microgram/min for 30 minutes to determine whether pressor responsiveness to AVP was altered in ACTH-induced hypertension. 2. Prior to ACTH treatment, AVP produced rises in blood pressure associated with a fall in heart rate and cardiac output. 3. During ACTH treatment, pressor responsiveness to AVP and decrease in cardiac output were unchanged, but reflex bradycardia was reduced. 4. ACTH-induced hypertension in sheep is not associated with enhanced pressor responsiveness to AVP.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced; D011311:Pressoreceptors / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012756:Sheep
D001127:Arginine Vasopressin; D000324:Adrenocorticotropic Hormone