[Oxidative phosphorylation of Krebs cycle substrates in experimental treatment of enterocolitis with cytochrome c].
After administration of exogenous cytochrome c into rats with enterocolitis, caused by salmonellae, tissue respiration and oxidative phosphorylation in presence of succinic, alpha-ketoglutaric, pyruvic and oxaloacetic acids were increased in the liver tissue. Treatment with cytochrome c produced a positive effect on the general state of an organism, led to disappearance of macroscopic alterations in mucosa of small intestine. The data obtained suggest that cytochrome c possesses the positive therapeutic effects in enterocolitis caused by salmonellae.
D000818:Animals; D002952:Citric Acid Cycle; D003574:Cytochrome c Group / Q000627:therapeutic use*; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D007656:Ketoglutaric Acids / Q000378:metabolism; D008297:Male; D010071:Oxaloacetates / Q000378:metabolism; D010085:Oxidative Phosphorylation; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D012481:Salmonella Infections, Animal / Q000188:drug therapy* / Q000378:metabolism; D012486:Salmonella typhimurium; D013386:Succinates / Q000378:metabolism
D003574:Cytochrome c Group; D007656:Ketoglutaric Acids; D010071:Oxaloacetates; D011773:Pyruvates; D013386:Succinates
Okislitel'noe fosforilirovanie nekotorykh substratov tsikla Krebsa pri éksperimental'noĭ terapii énterokolita tsitokhromom c.