title: Crystallization of pertussigen from Bordetella pertussis.
abstract: A method is described for crystallizing pertussigen from Bordetella pertussis. The crystalline material induced histamine hypersensitivity in mice at a dose of 0.5 ng of protein and leukocytosis at a dose of 100 ng and was toxic at a dose of 429 microgram. The histamine-sensitizing activity and the toxicity were as high as ever reported.
mesh_terms: D001427:Bacterial Toxins / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D001886:Bordetella pertussis / Q000032:analysis*; D003460:Crystallization; D006384:Hemagglutination; D006632:Histamine / Q000494:pharmacology; D007964:Leukocytosis / Q000139:chemically induced; D037342:Pertussis Toxin; D010566:Virulence Factors, Bordetella
chemical_list: D001427:Bacterial Toxins; D010566:Virulence Factors, Bordetella; D006632:Histamine; D037342:Pertussis Toxin