title: [Prophylaxis of gallstone formation (author's transl)].
abstract: Today we know the pathobiochemical mechanism of gallstone formation. Cholecystectomy is the therapy of choice with a mortality-rate 0,5% in uncomplicated cases. The mortality-rate increases in patients with recurrent stones in the biliary tract system after cholecystectomy. In addition the liver produces a lithogenic bile. We propose the prophylactic use of chenodesocycholic acid in patients after choledochal revision, if the bile duct system is altered in such a way that cholesterol crystals can aggregate and grow to stones. A low dose of cheno acid is sufficient. Moreover a fibre rich diet increases the chenodesoxycholic acid synthesis in the liver.
mesh_terms: D000368:Aged; D001646:Bile / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000627:therapeutic use*; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000178:diet therapy / Q000209:etiology / Q000517:prevention & control*; D004043:Dietary Fiber / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control
chemical_list: D004043:Dietary Fiber; D002635:Chenodeoxycholic Acid
vernacular_title: Indikation und Möglichkeiten der Prophylaxe beim Gallensteinleiden.