Animal model for small cell carcinoma of the lung. Effect of immunosuppression and sex of mouse on tumor growth in nude athymic mice.
An animal model for the experimental study of small cell carcinoma of the lung (SCCL; human) has been developed. Tumors arising from continuous cell lines of cultured tumor cells as well as transplantable tumors of human SCCL in nude athymic mice have been characterized as to growth rate and morphology. The effect of antilymphocyte and antithymocyte sera and the sex of the host mouse were evaluated.
D000818:Animals; D000917:Antibody Formation; D000961:Antilymphocyte Serum; D018288:Carcinoma, Small Cell / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007165:Immunosuppression Therapy; D008175:Lung Neoplasms / Q000276:immunology*; D051379:Mice; D008819:Mice, Nude / Q000276:immunology; D009368:Neoplasm Transplantation; D012737:Sex Factors; D013601:T-Lymphocytes / Q000276:immunology; D014183:Transplantation, Heterologous
D000961:Antilymphocyte Serum; D007136:Immunoglobulins