A novel GABA receptor modulates stimulus-induced glutamate release from cortico-striatal terminals.
The possibility of there being a population of GABA receptors located on cortico-striatal terminals is suggested by [3H]GABA binding studies. Experiments carried out to investigate the stimulus-induced release of glutamate from cortico-striatal terminals revealed an active modulation by a presynaptic GABA receptor. The differential responses of this receptor to a range of GABA agonists suggest that it may represent a novel type of GABA receptor.
D002540:Cerebral Cortex / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D066298:In Vitro Techniques; D009434:Neural Pathways / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*; D011963:Receptors, GABA-A
D005971:Glutamates; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A