Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity.
Lymphocytes infiltrating human primary mammary carcinomas lack ADCC and show low levels of natural cytotoxicity. The peripheral blood lymphocytes, however, show a variable but prominent level of cytotoxicity. Lymphocyte preparations from breast tumours, when mixed with autologous blood lymphocytes, significantly suppress their prominent killer- (K- and NK-) cell activities.
D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity; D001943:Breast Neoplasms / Q000276:immunology*; D002469:Cell Separation / Q000379:methods; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D003012:Microbial Collagenase / Q000494:pharmacology; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
D003012:Microbial Collagenase