title: Activated T lymphocytes in infiltrates and draining lymph nodes of nasopharyngeal carcinoma.
abstract: Lymphocytes isolated from the tumors and draining lymph nodes of nasopharyngeal carcinoma (NPC) patients exhibit the following characteristics of immune activation: (1) stable E rosette formation, (2) natural attachment to various human cells, (3) sensitivity in vitro to the lytic effect of glucocorticoids. Although the NPC T cells attach in vitro to various cells they kill only EBV-genome-carrying targets. These findings suggest the occurrence of a local cellular immune response in NPC, possibly directed to EBV-determined antigens.
mesh_terms: D002460:Cell Line; D002469:Cell Separation; D003602:Cytotoxicity, Immunologic; D005938:Glucocorticoids / Q000494:pharmacology; D004854:Herpesvirus 4, Human / Q000276:immunology; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000276:immunology*; D008213:Lymphocyte Activation; D009303:Nasopharyngeal Neoplasms / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D005938:Glucocorticoids