Anti-tremor action of C10Dichol, a peripheral acetylcholine synthesis inhibitor.
1 Anti-tremor action of decamethylene bis-(hydroxyethyl)-dimethylammonium bromide (C10Dichol), a peripheral acetylcholine synthesis inhibitor, was investigated. 2 C10Dichol inhibited tremor induced by oxotremorine, nicotine and physostigmine and afforded partial protection from physostigmine-induced mortality in mice. 3 In non-paralysing doses, C10Dichol antagonized the neuromuscular effects of oxotremorine, nicotine and physostigmine. 4 Prior administration of C10Dichol failed to prevent tremor and neuromuscular paralysis induced by harmine and arecoline. 5 In the absence of any antimuscarinic property of C10Dichol, its neuromuscular effects appeared to be casually related to its anti-tremor action. 6 This study reveals a possibility for the development of peripherally acting anti-Parkinson drugs.
D000109:Acetylcholine / Q000096:biosynthesis*; D000818:Animals; D001001:Anura; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010830:Physostigmine / Q000633:toxicity; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects; D014202:Tremor / Q000517:prevention & control*
D000644:Quaternary Ammonium Compounds; C028958:C10-Dichol; D010830:Physostigmine; D000109:Acetylcholine