title: Rat pregnancy immunoregulatory circuits are progestation hormonal status, decidual tissue, embryo-trophoblast and late pregnancy changes dependent.
abstract: We have tested the spleen cells of rats for their reactivity to mating and unrelated (third party) strain alloantigens during pregnancy, pseudopregnancy, and traumatic deciduoma installation. By cytotoxic T-lymphocyte assays, after 7-day one-way mixed lymphocyte cultures (MLC), we detected the presence of many immunoregulatory circuits among rat pregnancy and postpartum. They are progestation hormonal status, decidual tissue, embryo-trophoblast, late-pregnancy-parturition-associated changes, and lactation-hormonal-status dependent.
mesh_terms: D000818:Animals; D003656:Decidua / Q000276:immunology*; D010065:Embryo Implantation, Delayed; D005260:Female; D005865:Gestational Age; D007519:Isoantigens / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D049590:Postpartum Period; D011247:Pregnancy; D011270:Pregnancy, Animal; D011372:Progestins / Q000276:immunology*; D011555:Pseudopregnancy / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014327:Trophoblasts / Q000276:immunology*
chemical_list: D007519:Isoantigens; D011372:Progestins