Renal responsiveness to parathyroid hormone in a case of nonfamilial hypophosphatemic osteomalacia.
Plasma immunoreactive parathyroid hormone level, urinary excretion of adenosine cyclic 3',5'-monophosphate (cyclic AMP) and the sensitivity of the renal tubule to calcium infusion and to parathyroid extract were investigated in a patient with nonfamilial hypophosphatemic osteomalacia. Plasma immunoreactive parathyroid hormone concentration was normal and basal urinary excretion of cyclic AMP was increased. Renal cortical adenylate cyclase, as measured by urinary cyclic AMP excretion, was certainly as sensitive to exogenous parathyroid extract as in normal subjects. After a previous calcium infusion, a greater parathyroid-hormone-sensitive component of phosphorus transport in the kidney was present than in two control subjects. Our results indicate that in nonfamilial hypophosphatemic osteomalacia the renal tubule could be hyperresponsive to parathyroid hormone.
D002118:Calcium / Q000494:pharmacology; D000242:Cyclic AMP / Q000652:urine; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000627:therapeutic use*; D010710:Phosphates / Q000097:blood / Q000378:metabolism
D010281:Parathyroid Hormone; D010710:Phosphates; D000242:Cyclic AMP; D002118:Calcium