title: [Substances with antiviral activity. XIII.  Synthesis and in vitro activity of thiosemicarbazones of 1-benzoyl- and 1-benzyl-2-chloro-3-formylindoles].
abstract: A series of 1-benzoyl- and 1-benzyl-2-chloro-3-formylindole thiosemicarbazones was synthesized and investigated for antiviral activity against vaccinia virus IHD strain and parainfluenza virus type 3, HA-I/CR-8 strain. The results confirmed the previously observed high activity against vaccinia virus of m-substituted benzoyl derivatives. On the contrary, the analogous benzyl derivatives showed marginal activity; the compound (V c), however, was the most active against the parainfluenza virus.
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D018108:Respirovirus / Q000187:drug effects; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D014616:Vaccinia virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D007211:Indoles; D013882:Thiosemicarbazones
vernacular_title: Ricerche su sostanze ad attività antivirale. Nota XIII - Sintesi ed attività in vitro di tiosemicarbazoni di 1-benzoiled 1-benzil-2-cloro-3-formilindoli.