title: Cell cycle mutants of mammalian cells in culture. Present interest and limits to the study of thermodependent mutants.
abstract: Mammalian variants with a defect altering the cell cycle progression have been selected, characterized to different extents and preliminary genetic analysis has been carried out. The difficulties encountered in their study are discussed below. Up to now, they have limited the genetic approach to the cell cycle.
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002460:Cell Line; D002478:Cells, Cultured / Q000502:physiology*; D002522:Chlorocebus aethiops; D006224:Cricetinae; D003412:Cricetulus; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D006822:Hybrid Cells / Q000502:physiology; D007399:Interphase; D008647:Mesocricetus; D051379:Mice; D008938:Mitosis; D009153:Mutagens; D009154:Mutation; D010641:Phenotype; D051381:Rats; D012641:Selection, Genetic; D013696:Temperature
chemical_list: D009153:Mutagens