title: Collagen fibril diameters and glycosaminoglycan content of skins--indices of tissue maturity and function.
abstract: Samples of anatomically and functionally distinct regions of the skin of a variety of altricial and precocial animals were taken at various stages of development from birth to beyond maturity. The glycosaminoglycan (GAG) content and composition of the tissues were determined by chemical analysis and the collagen fibril diameters measured by transmission electron microscopy. The fibril diameters of the skins of two fish and a bird were also assessed for comparison. Analysis and comparison of the data collected show that there was a significant correlation between collagen fibril diameter distribution, GAG type and amount, and functional load-bearing of the various skins, and that the variations in the biochemical and physical composition of the tissues at different stages of development could be related to both their post-conceptual maturity and their prospective functional loading.
mesh_terms: D008841:Actin Cytoskeleton / Q000648:ultrastructure; D000375:Aging; D000818:Animals; D002645:Chickens; D003094:Collagen / Q000032:analysis*; D006224:Cricetinae; D004285:Dogs; D006025:Glycosaminoglycans / Q000032:analysis*; D006801:Humans; D007798:Lampreys; D008854:Microscopy, Electron; D051381:Rats; D012756:Sheep; D012867:Skin / Q000648:ultrastructure; D012879:Skin Physiological Phenomena; D013045:Species Specificity; D014337:Trout
chemical_list: D006025:Glycosaminoglycans; D003094:Collagen