title: Transposition of the oxacillin-hydrolyzing penicillinase gene.
abstract: We have found that the oxacillin-hydrolyzing penicillinase gene (oxa) encoded by plasmid RGN238 transposes to various plasmids in a recA background. We call this transposable element Tn2603. Tn2603 encodes the genes for streptomycin, sulfonamide, and mercury resistance in addition to the oxa gene. Tn2603 has a molecular size of 19.6 kilobase pairs and appears to be flanked by small inverted repeat sequences of about 200 base pairs long.
mesh_terms: D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D009695:Nucleic Acid Renaturation; D010068:Oxacillin / Q000378:metabolism*; D010405:Penicillinase / Q000235:genetics*; D011815:R Factors; D012091:Repetitive Sequences, Nucleic Acid; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D010405:Penicillinase; D001618:beta-Lactamases; D010068:Oxacillin