Intestinal M cells: a pathway for entry of reovirus into the host.
Thirty minutes after inoculation of reovirus type 1 into the intestinal lumen of the mouse, viruses were found adhering to the surface of intestinal M cells but not other epithelial cells. Within 1 hour, viruses were seen in the M cell cytoplasm and were associated with mononuclear cells in the intercellular space adjacent to the M cell. These findings suggest that M cells are the site where reovirus penetrates the intestinal epithelium.
D000818:Animals; D000833:Animals, Suckling / Q000382:microbiology; D004705:Endocytosis; D005110:Extracellular Space / Q000382:microbiology; D007413:Intestinal Mucosa / Q000166:cytology / Q000382:microbiology*; D051379:Mice; D010581:Peyer's Patches / Q000382:microbiology; D011991:Receptors, Virus / Q000378:metabolism; D012087:Reoviridae / Q000502:physiology*; D012088:Reoviridae Infections / Q000473:pathology*
D011991:Receptors, Virus