title: Cyproheptadine in the control of Cushing's disease.
abstract: A patient with Cushing's disease was treated with cyproheptadine with concomitant remission of the disease for 60 months. Despite clinical improvement and achievement of normal levels of cortisol excretions, her menstruation-related cyclic surge of cortisol secretion was supranormal. The mode of action of cyproheptadine was studied by the administration of metyrapone. Long-term administration of cyproheptadine appeared to normalize excessive adrenocorticotropic hormone (ACTH) production by reducing the frequency and the peak levels of episodic secretion of ACTH.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003480:Cushing Syndrome / Q000188:drug therapy*; D003533:Cyproheptadine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008797:Metyrapone
chemical_list: D003533:Cyproheptadine; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D008797:Metyrapone