Potentiation by polymyxin B of the bronchoconstriction following allergen inhalation in patients with atopic asthma.
The effect of a single inhalation of allergen on bronchial reactivity to polymyxin B was studied in eight patients with hay fever. In winter the reaction to polymyxin B before and after inhalation of pollen allergen is measured by the FEV. In all patients bronchial reactivity to polymyxin B increased under the influence of allergen.
D000485:Allergens / Q000008:administration & dosage*; D001986:Bronchial Spasm / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005541:Forced Expiratory Volume; D006801:Humans; D011058:Pollen; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*
D000485:Allergens; D011113:Polymyxins; D011112:Polymyxin B