[Virus-specific IgM proof with routine serologic methods (author's transl)].
By the use of a specific immunosorption to insoluble adsorbentia (controlled-pore glass, polystyrene particles) the separation of IgM and IgG is performed in serum specimens, which originate from patients presenting several virus infections (mumps, measles, cytomegalovirus, herpes simplex), for the virus-specific IgM proof with routine serologic methods (CFT, HIT, NT). The results are in a good agreement to them seen in the demonstration of significant titer rises to assure the diagnosis of acute mumps and measles infections by HIT rapidly. While the new technique is also successfully applied for the determination of neutralizing IgM and IgA antibodies to HSV, no sufficient results are available to detect CMV specific IgM antibodies by CFT compared to other methods (IFT, ELISA).
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003168:Complement Fixation Tests; D003586:Cytomegalovirus Infections / Q000175:diagnosis; D006385:Hemagglutination Inhibition Tests; D006561:Herpes Simplex / Q000175:diagnosis; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007164:Immunosorbents; D007223:Infant; D007231:Infant, Newborn; D008457:Measles / Q000175:diagnosis; D008875:Middle Aged; D009107:Mumps / Q000175:diagnosis; D009500:Neutralization Tests; D014777:Virus Diseases / Q000175:diagnosis*
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D007164:Immunosorbents
Virusspezifischer IgM-Nachweis mit Routinemethoden.