Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome.
The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted from integration of an ecotropic provirus into the mouse genome.
D000818:Animals; D001483:Base Sequence; D002472:Cell Transformation, Viral; D002874:Chromosome Mapping; D004279:DNA, Viral / Q000235:genetics; D008040:Genetic Linkage; D009052:Leukemia Virus, Murine / Q000235:genetics*; D051379:Mice; D008811:Mice, Inbred DBA / Q000235:genetics*; D008817:Mice, Mutant Strains / Q000235:genetics*; D011995:Recombination, Genetic
D004279:DNA, Viral