title: Calcium dependence of synaptic transmission in the hippocampal slice.
abstract: 'Population' afferent spike and 'population' EPSP were recorded with extracellular microelectrodes in slices of hippocampal tissue maintained in vitro. Calcium concentration was changed in the bathing solution, and calcium activity ([Ca2+]0) was measured in interstitial fluid of the slice with ion-selective microelectrodes. Synaptic transfer was a non-linear continuous function of [Ca2+]0. Deviation of [Ca2+]0 by 0.1 mM from the 1.2 mM control level caused a change of approximately 15% in the slope of the input-output function.
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D046508:Culture Techniques; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D007700:Kinetics; D051381:Rats; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D007473:Ion Channels; D002118:Calcium