Hypothalamo-pituitary-adrenal axis in patients with prostatic carcinoma.
Insulin-induced pituitary growth hormone (GH), adrenocorticotrophic hormone (ACTH) and adrenal cortical response were studied in 12 patients with prostatic carcinoma. 3 patients demonstrated significant abnormal GH release associated with concentrations which remained on a high plateau during the study. 5 patients showed lack of ACTH-cortisol response to insulin-induced hypoglycemia. Those patients subsequently presented clinically with rapidly progressing disease.
D000230:Adenocarcinoma / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011471:Prostatic Neoplasms / Q000503:physiopathology*
D007328:Insulin; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone