title: [Action of antibiotics on the growth and metabolic processes of streptomycetes and Nocardia].
abstract: New experimental data on the effect of novobiocin, ristomycin and nystatin on growth and metabolism of Streptomycetes and Nocardia are presented. The study of the organisms producing other antibiotics showed that they were tens, hundreds and even thousands times more sensitive to the tested biologically active compounds than the organisms producing these compounds. The protein synthesis and antibiotic biosynthesis proved to be most sensitive out of the processes studied. The findings showed that during their evolution the antibiotic-producing organisms have developed definite protective mechanisms which enable them to resist relatively high concentrations of their own metabolites (antibiotics). This ensures them in their struggle for existence.
mesh_terms: D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects* / Q000502:physiology; D009675:Novobiocin / Q000494:pharmacology*; D009761:Nystatin / Q000494:pharmacology*; D012310:Ristocetin / Q000494:pharmacology*; D013302:Streptomyces / Q000187:drug effects* / Q000502:physiology
chemical_list: D009761:Nystatin; D012310:Ristocetin; D009675:Novobiocin
vernacular_title: Izuchenie deĭstviia antibiotikov na rost i protsessy metabolizma u streptomitsetov i nokardii.