title: [Xanthine oxidase--xanthines as a system of endogenous regulation of phosphodiesterase activity].
abstract: The paper is concerned with the data indicating close interaction between xanthinoxidase (Xase) and phosphodiesterase (PDE). PDE activity can be modified by affecting the activity of Xase. This effect is mediated by changes in the concentrations of endogenous xanthines. The action of PDE inhibitors, methylxanthines, is discussed from the point of view of the above effect. The data obtained hold promise for purposeful monitoring of tissue concentrations of the cyclic nucleotides in vivo and in vitro.
mesh_terms: D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000032:analysis; D066298:In Vitro Techniques; D008099:Liver / Q000032:analysis / Q000201:enzymology*; D008982:Molybdenum / Q000494:pharmacology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D051381:Rats; D013806:Theophylline / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000378:metabolism*; D014970:Xanthines / Q000494:pharmacology / Q000502:physiology*
chemical_list: D000644:Quaternary Ammonium Compounds; D014970:Xanthines; D000493:Allopurinol; D008982:Molybdenum; D013806:Theophylline; D000242:Cyclic AMP; D014969:Xanthine Oxidase; D010727:Phosphoric Diester Hydrolases
vernacular_title: Ksantinoksidaza--ksantiny kak sistema éndogennoĭ reguliatsii aktivnosti fosfodiésterazy.