Polymyxin B inactivation of lipopolysaccharide in vaccines of Gram-negative bacteria.
Endotoxin activity in suspensions of Bordetella pertussis, Escherichia coli, Haemophilus influenzae, and Pseudomonas aeruginosa was often markedly decreased by polymyxin B. Polymyxin B treatment may be a means to reduce inflammatory reactivity of lipopolysaccharide in vaccines of gram-negative bacteria.
D001428:Bacterial Vaccines; D004926:Escherichia coli / Q000276:immunology; D006193:Haemophilus influenzae / Q000276:immunology; D008033:Limulus Test; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D010567:Pertussis Vaccine; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000276:immunology
D001428:Bacterial Vaccines; D008070:Lipopolysaccharides; D010567:Pertussis Vaccine; D011113:Polymyxins; D011112:Polymyxin B