Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D003994:Bucladesine / Q000037:antagonists & inhibitors; D004273:DNA, Neoplasm / Q000096:biosynthesis; D008453:Maytansine / Q000031:analogs & derivatives / Q000494:pharmacology*; D051379:Mice; D008870:Microtubules / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D010078:Oxazines / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D014404:Tubulin / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D004273:DNA, Neoplasm; D010078:Oxazines; D014404:Tubulin; D008453:Maytansine; D003994:Bucladesine; C015682:ansamitocins