title: Chemotherapy for adenocystic carcinoma.
abstract: Seventeen patients with adenocystic carcinoma have received 34 adequate trials of chemotherapy at Princess Margaret Hospital since 1969. There have been five objective responses to chemotherapy in 4 cases, lasting from five to 24 months, and 3 other patients have had stabilized disease for a period of five to seven months. Responding and stabilized patients all had symptomatic improvement. Most responses were to 5-fluorouracil, the preferred drug for initial treatment of metastatic disease or locoregional disease that cannot be controlled by means of surgery or radiation therapy.
mesh_terms: D000477:Alkylating Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003528:Carcinoma, Adenoid Cystic / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008727:Methotrexate / Q000008:administration & dosage; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D013997:Time Factors; D014748:Vinca Alkaloids / Q000008:administration & dosage
chemical_list: D000477:Alkylating Agents; D000970:Antineoplastic Agents; D014748:Vinca Alkaloids; D005472:Fluorouracil; D008727:Methotrexate