title: Dietary fibre and colon cancer: epidemiologic and experimental evidence.
abstract: Epidemiologic studies have identified two dietary factors, a relatively high intake of fat and a relatively low intake of fibre, that are associated with colon cancer in humans. However, a recent study has shown a low risk of large bowel cancer in a rural Finnish population with a high dietary intake of fat, but also a high intake of fibre. Observations in humans and studies in animals have indicated that dietary fibre may protect against colon carcinogenesis by binding bile acids in the intestinal tract, by a direct effect on the colonic mucosa and by an indirect effect on the metabolism of carcinogens. The strength of protection varies with the type of fibre.
mesh_terms: D000818:Animals; D002482:Cellulose; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D004032:Diet; D004041:Dietary Fats / Q000378:metabolism; D004043:Dietary Fiber; D005243:Feces / Q000032:analysis; D005260:Female; D005387:Finland; D006801:Humans; D007564:Japan; D008297:Male; D009656:North America; D051381:Rats; D012067:Religion; D012959:Socioeconomic Factors
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber; D002482:Cellulose