Isolated parotid acinar cells from patients with cystic fibrosis. Functional characterization.
Studies of the homeostasis and secretory function of isolated parotid acinar cells from patients with cystic fibrosis were conducted. It was demonstrated that the transmembrane fluxes of Na and the muscarinic cholinergic receptor stimulus-secretion coupling were depressed, while the stimulus-secretion coupling of the beta-adrenergic receptor was hyper-reactive.
D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003550:Cystic Fibrosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D010306:Parotid Gland / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D011976:Receptors, Muscarinic / Q000502:physiology; D012964:Sodium / Q000378:metabolism
D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D012964:Sodium; D002118:Calcium