Rat brain cyclic AMP levels and withdrawal behavior following treatment with t-butanol.
1. The time course development of physical dependence as assessed by the withdrawal reaction was identical for ethanol and t-butanol. 2. t-Butanol is most likely not metabolized by the liver and is eliminated from the rat 6 to 7% as rapidly as ethanol. 3. Blood and brain acetaldehyde could not be detected following treatment with t-butanol. 4. At the peak of withdrawal, cyclic AMP levels were indistinguishable from control values following treatment with either ethanol or t-butanol.
D000079:Acetaldehyde / Q000097:blood; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000440:Butanols / Q000097:blood / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D000431:Ethanol / Q000097:blood / Q000494:pharmacology; D005260:Female; D006801:Humans; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D014018:Tissue Distribution
D000440:Butanols; D000431:Ethanol; D000242:Cyclic AMP; D000079:Acetaldehyde