Metabolic abnormalities of human adenosine deaminase deficiency reproduced in the mouse by 2'-deoxycoformycin, and adenosine deaminase inhibitor.
D000243:Adenosine Deaminase / Q000172:deficiency* / Q000378:metabolism; D058892:Adenosine Deaminase Inhibitors; D043383:Adenosylhomocysteinase; D000818:Animals; D001835:Body Weight; D003070:Coformycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D003838:Deoxyadenine Nucleotides / Q000378:metabolism; D003839:Deoxyadenosines / Q000652:urine; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006867:Hydrolases / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009700:Nucleoside Deaminases / Q000172:deficiency*; D009929:Organ Size; D015649:Pentostatin; D010770:Phosphotransferases / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor); D012263:Ribonucleosides / Q000494:pharmacology*; D013950:Thymus Gland / Q000033:anatomy & histology
D058892:Adenosine Deaminase Inhibitors; D003838:Deoxyadenine Nucleotides; D003839:Deoxyadenosines; D012263:Ribonucleosides; D003070:Coformycin; D015649:Pentostatin; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C020005:deoxyadenosine kinase; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; C026600:2'-deoxyadenosine triphosphate