Effect of cholecystokinin octapeptide sulphate ester on brain monoamines in the rat.
The effect of different doses of intracerebro-ventricularly administered cholecystokinin octapeptide sulphate ester (CCK-8-SE) was studied on dopamine (DA), norepinephrine (NE) and serotonin (5-HT) contents in the hypothalamus, mesencephalon, amygdala, septum and striatum, 10, 20 and 60 min following administration. The DA and NE content increased and the 5-HT content decreased in the hypothalamus and mesencephalon. A biphasic action was observed in the amygdala of DA, NE and 5-HT depending upon the time and doses used. Similar action was seen on DA and NE in the septum. In the striatum, the DA and 5-HT content decreased while the NE level first increased and then decreased. The data indicate that the CCK-8-SE is able to modify the activity of DA, NE and 5-HT in different brain regions in a time and dose-dependent manner, with a local specific action.
D000679:Amygdala / Q000032:analysis; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D051381:Rats; D012688:Septum Pellucidum / Q000032:analysis; D012701:Serotonin / Q000032:analysis*; D012844:Sincalide; D014793:Visual Cortex / Q000032:analysis
D001679:Biogenic Amines; D012701:Serotonin; D002766:Cholecystokinin; D012844:Sincalide