Brain glycoprotein in tumours of the nervous system.
We studied various tumours of the nervous system by the immunofluorescence technique using an anti-brain specific alpha 2 glycoprotein antiserum (anti-NSA3 antiserum). We found the antigen in 24/27 astrocytomas and 4/4 oligodendrogliomas but in none of the 8 meningiomas tested. There was an identity between the astrocytoma/oligodendroglioma antigen and that of normal brain as shown by the immunoprecipitation technique. By the immunofluorescence technique using inhibition of the antiserum we demonstrated that the tumour antigen is devoid of some specific nervous system determinants present in normal brain.
D000951:Antigens, Neoplasm / Q000032:analysis; D001254:Astrocytoma / Q000032:analysis; D001932:Brain Neoplasms / Q000032:analysis* / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005909:Glioblastoma / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D008527:Medulloblastoma / Q000032:analysis; D008577:Meningeal Neoplasms / Q000032:analysis; D008579:Meningioma / Q000032:analysis; D009442:Neurilemmoma / Q000032:analysis; D009447:Neuroblastoma / Q000032:analysis; D009837:Oligodendroglioma / Q000032:analysis
D000951:Antigens, Neoplasm; D006023:Glycoproteins