[Acute cotrimoxazole-induced thrombocytopenia, facilitating role of phenobarbital (author's transl)].
A fifty-year-old-woman treated by phenobarbital for seven months developed an acute thrombocytopenia while taking cotrimoxazole for eight days, because of urinary tract infection. The antifolic effect of these two drugs may be increased when they are taken together, and then may be the cause of hematologic disorders. Therefore the authors think these two drugs must not be given together.
D000208:Acute Disease; D004338:Drug Combinations / Q000009:adverse effects; D004357:Drug Synergism; D005260:Female; D005492:Folic Acid / Q000097:blood; D005493:Folic Acid Antagonists; D006801:Humans; D008875:Middle Aged; D010634:Phenobarbital / Q000009:adverse effects*; D013420:Sulfamethoxazole / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D005493:Folic Acid Antagonists; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D005492:Folic Acid; D014295:Trimethoprim; D013420:Sulfamethoxazole; D010634:Phenobarbital
Thrombopénie aiguë au cortrimoxazole. Rôle facilitant du phénobarbital.