Control of the variability of the afferent discharge rate in frog muscle spindle by potassium blockers.
Blockage of the K+ channels in the sensory terminal of frog muscle spindle by the combined application of BaCl2 and other K+ blockers makes it possible to reversibly change the sustained and irregular discharges into non-sustained regular discharges. As a similar change in the discharge pattern is also made by application of CoCl2 alone, though it is irreversible, the irregular and sustained discharge may be due to [Ca2+]i-activated potassium conductance.
D000344:Afferent Pathways / Q000187:drug effects*; D000818:Animals; D001464:Barium / Q000494:pharmacology; D017609:Barium Compounds; D002586:Cesium / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects; D009470:Muscle Spindles / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism*; D011898:Ranidae; D009435:Synaptic Transmission / Q000187:drug effects*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D017609:Barium Compounds; D002712:Chlorides; D007473:Ion Channels; D013757:Tetraethylammonium Compounds; C024986:barium chloride; D002586:Cesium; D001464:Barium; D003035:Cobalt; D019789:Tetraethylammonium; C018021:cobaltous chloride; C028019:cesium chloride; D011188:Potassium