Increase in epithelial cyclic adenosine 3',5'-monophosphate following vanadate.
Vanadate increases the cyclic adenosine 3',5'-monophosphate (cyclic AMP) content of frog skin epithelium and apparently antagonizes the stimulation by isoprenaline. The effect appears to be a direct activation of adenyl cyclase. This new effect of vanadate together with the inhibitory effects on Na-K ATPase may explain the irregular effects on sodium transport.
D000818:Animals; D001001:Anura; D001693:Biological Transport, Active / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D011896:Rana temporaria; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology; D014639:Vanadium / Q000494:pharmacology*
D014639:Vanadium; D012964:Sodium; D013806:Theophylline; D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase; D007545:Isoproterenol