[Treatment of pertussis with cefoperazone (author's transl)].
Clinical trial of cefoperazone (CPZ) for the treatment of 15 cases suffering from pertussis was performed and the results were as follows. The method of administration, as a rule intravenous infusion was performed at 100 approximately 200 mg/kg/day. (1) Seventeen strains of Bordetella pertussis showed under 0.006 mcg/ml of MIC. It was similar to PIPC. (2) Any effect to hepatic or renal function was not observed. (3) Clinical response obtained in these cases was excellent in 13 cases (86.7%), good in 2 cases (13.3%) and none of poor case.
D000367:Age Factors; D001886:Bordetella pertussis / Q000187:drug effects; D002438:Cefoperazone; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use*; D004341:Drug Evaluation; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D014917:Whooping Cough / Q000188:drug therapy* / Q000382:microbiology
D002511:Cephalosporins; D002438:Cefoperazone