Cardiac beta-adrenoceptors and adenylyl cyclase activity in rabbit heart during conditions of altered sympathetic activity.
Chronic (2 weeks) guanethidine treatment of rabbits depleted left ventricular noradrenaline and increased sarcolemmal beta-receptor density and protein yield. Total adenylyl cyclase activity was unchanged. Chronic sinoaortic denervation did not affect ventricular catecholamines and only marginally reduced beta-receptor numbers.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006145:Guanethidine / Q000494:pharmacology; D006321:Heart / Q000033:anatomy & histology; D006339:Heart Rate / Q000187:drug effects; D009124:Muscle Proteins; D009206:Myocardium / Q000201:enzymology*; D009929:Organ Size; D011817:Rabbits; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D013564:Sympathetic Nervous System / Q000187:drug effects*
D009124:Muscle Proteins; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D000262:Adenylyl Cyclases; D006145:Guanethidine