Effect of mitomycin C and hydroxyurea on the expression of the Epstein-Barr virus cycle following P3HR-1 superinfection.
Epstein-Barr virus (EBV) DNA synthesis following EBV P3HR-1 superinfection of the Burkitt lymphoma cell line, Daudi, is refractory to mitomycin C and hydroxyurea at concentrations which inhibit cell DNA synthesis to greater than 98% of control values. Further, neither mitomycin C nor hydroxyurea inhibit virus antigen synthesis following P3HR-1 superinfection.
D000956:Antigens, Viral; D002051:Burkitt Lymphoma; D002460:Cell Line; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D004279:DNA, Viral / Q000096:biosynthesis*; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology*; D008937:Mitomycins / Q000494:pharmacology*; D009693:Nucleic Acid Hybridization
D000956:Antigens, Viral; D004279:DNA, Viral; D008937:Mitomycins; D003561:Cytarabine; D004247:DNA; D006918:Hydroxyurea