[Therapy of severe acne and acne rosacea with oral 13-cis-retinoic acid (Isotretinoin)].
Forty patients suffering of different forms of acne (papulo-pustular, nodulo-cystic, conglobata, rosacea), all in severe conditions and non-responding to other treatments, have been administered 13-cis-retinoic acid p.o. The treatment resulted in a complete and ultimate healing in 31 pts (77.5%) and a marked amelioration in the remaining 9 cases. The initial drug dosage was 40 mg/die (an average of 0.66 mg/kg/die) but it was reduced along the treatment to 2.5 mg/die, a still effective dose. The average treatment duration was 24 weeks (range: 12 to 40). The tolerance was generally excellent, but some adverse effect have been recorded, mainly localized in the skin and mucosa. Increases of total serum cholesterol (66% of the cases) and of triglyceride (72%) level have been observed. This effect was reversible at the end of the treatment. As a conclusion we can confirm that the 13-cis-retinoic acid is the most effective drug for the pharmacotherapy of severe acne.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D000505:Alopecia / Q000139:chemically induced; D002784:Cholesterol / Q000097:blood; D004361:Drug Tolerance; D004844:Epistaxis / Q000139:chemically induced; D005260:Female; D006801:Humans; D015474:Isotretinoin; D008297:Male; D011537:Pruritus / Q000139:chemically induced; D012393:Rosacea / Q000188:drug therapy*; D000637:Transaminases / Q000378:metabolism; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D014212:Tretinoin; D002784:Cholesterol; D000637:Transaminases; D000469:Alkaline Phosphatase; D015474:Isotretinoin
La terapia dell'acne grave e della Rosacea con acido 13-cis-retinoico (Isotretinoin) per via orale.