title: Comparison of beta 1- and beta 2-receptor stimulation in oestrogen or progesterone dominated rat uterus.
abstract: Electrical stimulation of rat uterine preparations induced constant and reproducible contractions. The inhibitory effect of some adrenergic substances was tested on oestrogen- or progesterone-primed electrically stimulated rat uteri. The rank order of the relative potencies of some adrenergic agonists was shifted from Iso greater than E greater than Salb greater than Ne greater than H 133/22 greater than Phe greater than Clo in the oestrogen primed uterus to Iso greater than Salb greater than E greater than Ne greater than Phe greater than Clo greater than H 133/22 in progesterone primed uterus. The selective beta 2- agonist salbutamol was relatively more potent in progesterone treated rats than in oestrogen treated, while the beta 1-agonist H 133/22 was more potent in oestrogen dominated uterus. We therefore suggested that beta 2-receptors is dominating in the progesterone primed uterus, while both beta 1 and beta 2-receptors could be found in oestrogen primed uterus. No dissociation between the inhibitory effect on contractility and the cAMP increasing effect of isoprenaline could be demonstrated in rat uteri.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004558:Electric Stimulation; D004967:Estrogens / Q000502:physiology*; D005260:Female; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D011374:Progesterone / Q000502:physiology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013015:Sotalol / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D004967:Estrogens; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011374:Progesterone; D013015:Sotalol; D000242:Cyclic AMP; D007545:Isoproterenol