Changes in the cell surface architecture in normal and polyoma virus transformed hamster cells after infection with influenza virus.
Test of Con A induced cell agglutination, method of binding cells to Con A coated nylon fibres and modified procedure of cell-to-cell binding were used in the investigation of architectural surface changes in normal and polyoma virus transformed hamster cells infected with influenza virus. In both cell types influenza virus infection caused 1) increase in fixation resistant Con A agglutination, 2) decrease in the level of surface membrane fluidity and cell plasticity. It has postulated that influenza virus infection results in stabilization of the cell surface architecture. These changes are amplified by polyoma virus transformation. Con A acts in this system, as an indicator rather than as a modifier of architectural changes.
D000371:Agglutination; D000818:Animals; D002462:Cell Membrane / Q000473:pathology*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003208:Concanavalin A; D006224:Cricetinae; D003412:Cricetulus; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D008168:Lung; D009976:Orthomyxoviridae Infections / Q000473:pathology*; D011120:Polyomavirus
D003208:Concanavalin A