Localization of factor-VIII-related antigen in human vascular subendothelium.
Factor-VIII-related antigen has previously been shown to be synthesized by vascular endothelial cells. Using both an immunofluorescent staining technique and electron microscopy, we have demonstrated the presence of factor-VIII-related antigen in human vascular subendothelium. This finding may have implications in the mechanism of platelet adhesion to deendothelialized blood vessel surfaces.
D000818:Animals; D000941:Antigens; D001485:Basement Membrane / Q000276:immunology; D004727:Endothelium / Q000276:immunology; D005169:Factor VIII / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D003012:Microbial Collagenase / Q000494:pharmacology; D010973:Platelet Adhesiveness; D011817:Rabbits; D012501:Saphenous Vein / Q000276:immunology*; D014470:Umbilical Cord / Q000648:ultrastructure; D014471:Umbilical Veins / Q000276:immunology*
D000941:Antigens; D005169:Factor VIII; D003012:Microbial Collagenase