[Effect of vitamin D on cellularity and mechanical fragility of lysosomes: experiments on carrageenan granuloma cells].
In rats daily treated with vitamin D3 (5 micrograms/g of body weight/d for 5 d), the subcutaneous charrageenan granuloma shows reduced cellularity, mesenchimal cells degenerative process, increased mechanical fragility of lysosomes, oedema and modified fibrillogenesis of stroma. These effects are related to vitamin D3 action on cytomembranes.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002351:Carrageenan; D002762:Cholecalciferol / Q000494:pharmacology / Q000627:therapeutic use*; D004247:DNA / Q000032:analysis; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects*; D008297:Male; D011506:Proteins / Q000032:analysis; D051381:Rats
D011506:Proteins; D002762:Cholecalciferol; D002351:Carrageenan; D004247:DNA; D000135:Acid Phosphatase; D005966:Glucuronidase
Azione della vitamina D sulla cellularita' e sulla fragilita' meccanica dei lisosomi: esperienze su cellule di granulomi da carragenina.