Breast cancer patient's cell-mediated immune response to Thomsen-Friedenreich (T) antigen.
Thomsen-Friedenreich (T) antigenic specificity as determined with human serum anti-T was found in reactive form in breast adenocarcinomata but not in healthy and generally not in benign breast tissues. T-antigenic specificity was demonstrable in all metastatic breast carcinoma lesions. T specificity was also present in adeno- and squamous cell carcinomata from other organs; it was not found in the four melanomata, one glioblastoma, and seven benign non-breast tumors. Breast carcinoma patients but not healthy people showed cellular immunity to T antigen in vivo and in vitro. Most striking was the delayed-type cutaneous hypersensitivity reaction that was positive in over 85% of the ductal breast carcinoma patients tested, negative in over 94% benign breast disease patients, and in all presumably healthy individuals investigated. T antigen is readily available from healthy red blood cells in uncontaminated form, and free of HL-A and Australia antigens.
D000230:Adenocarcinoma / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000276:immunology*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007961:Leukocyte Migration-Inhibitory Factors / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011946:Receptors, Antigen
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D007961:Leukocyte Migration-Inhibitory Factors; D011946:Receptors, Antigen