[Susceptibility of the liver to lipid peroxidation after treatment with paracetamol].
Intoxication of rats with paracetamol (2.0 g/kg, b. wt.,os) is not followed by peroxidative decomposition of liver microsomal lipids "in vivo" but seems to interfere with ATPase and 5'-Nucleotidase activity in isolated plasmamembranes. Treatment with reduced glutathione, cys=teine and 2. mercaptopropionylglycine results in partial protection against liver injury provoked by the toxin. However, these sulphydryl compounds are not able to prevent the fall of liver GSH content occurring after paracetamol.
D000082:Acetaminophen / Q000506:poisoning*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D003545:Cysteine / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009708:Nucleotidases / Q000378:metabolism; D051381:Rats; D008625:Tiopronin / Q000494:pharmacology
D000082:Acetaminophen; D008625:Tiopronin; D009708:Nucleotidases; C030287:nucleotidase; D000251:Adenosine Triphosphatases; D005978:Glutathione; D003545:Cysteine
Suscettibilita' del fegato alla perossidazione pipidica dopo trattamento con paracetamolo.