Alpha 1-adrenoceptor activation stimulates ureogenesis in rat hepatocytes.
Epinephrine produced a dose-dependent stimulation of ureogenesis. Epinephrine action was unaffected by the beta-adrenergic antagonist propranolol but was blocked by the alpha-adrenergic antagonists prazosin and yohimbine. Prazosin was approximately 3 orders of magnitude more potent than yohimbine, indicating that the adrenoceptor involved in this action is of the alpha 1-subtype.
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D014508:Urea / Q000096:biosynthesis*; D015016:Yohimbine / Q000494:pharmacology
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D014508:Urea; D011433:Propranolol; D011224:Prazosin; D004837:Epinephrine