Early events following the binding of epidermal growth factor to surface receptors on ovarian granulosa cells.
Receptors for epidermal growth factor (EGF) have been localized on the surface of ovarian granulosa cells using a colloidal gold avidin complex in conjunction with biotinylated EGF. On cells incubated at low temperature the receptors are predominantly monodisperse and have a random distribution. When cells are warmed to 37 degrees C the receptors aggregate into clusters.
D000818:Animals; D001710:Biotin / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010053:Ovary / Q000166:cytology*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D001710:Biotin; D066246:ErbB Receptors