Lack of response of 1,25-dihydroxycholecalciferol to exogenous parathyroid hormone in a patient with treated pseudohypoparathyroidism.
The response of serum 1,25-dihydroxycholecalciferol (1,25-OH2CC) concentration to the administration of parathyroid extract (PTE) was studied in a patient with pseudohypoparathyroidism (PHP) type 1, 3 days after withdrawal of dihydrotachysterol (DHT) treatment. The patient had had a normal serum calcium (Ca), phosphorus (P) and immunoreactive parathyroid hormone (iPTH) level on DHT for 6 years. After PTE administration no rise of the 1,25-OH2CC concentration and no response of urinary cAMP and P were seen.
D000328:Adult; D002117:Calcitriol; D000242:Cyclic AMP / Q000652:urine; D004097:Dihydrotachysterol / Q000627:therapeutic use; D004100:Dihydroxycholecalciferols / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000378:metabolism*; D007011:Hypoparathyroidism / Q000378:metabolism / Q000503:physiopathology; D010281:Parathyroid Hormone; D010758:Phosphorus / Q000652:urine; D011547:Pseudohypoparathyroidism / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D010758:Phosphorus; D000242:Cyclic AMP; D002117:Calcitriol; D004097:Dihydrotachysterol