title: Clinically occult breast cancer. Multicentricity and implications for treatment.
abstract: Two hundred thirty-two biopsies have been performed for nonpalpable mammary lesions, detectable by mammography, but not clinically apparent. Sixty-two malignancies were demonstrated within this group, including thirty invasive ductal cancers, seven minimally invasive ductal cancers, 20 noninvasive ductal cancers, and five lobular carcinomas-in situ. When mastectomy specimens were examined for evidence of multifocal cancer in quadrants other than that in which the primary was located, 39.6% of the breasts examined demonstrated evidence of multifocal cancer ductal or lobular, invasive or non-invasive. These findings suggest that any therapeutic procedure for invasive or noninvasive ductal cancer which does not include total mastectomy may leave behind foci of cancer which may be a threat to the patient.
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008327:Mammography; D008408:Mastectomy / Q000379:methods; D008875:Middle Aged