title: [Age-dependence of adenosine deaminase activity in mouse lymphocytes from the spleen and thymus].
abstract: The ADA activity was determined in splenocytes and thymocytes of female CBA-mice in dependence on the age of the animals. The investigations were carried out in period of 0 to 120 weeks, the enzyme activities of corresponding cells of animals in the age of 6 weeks served as controls. Whereas the ADA activity of splenocytes did not change during the time of investigations (P = 5%; not significant in analysis of variance), the enzyme activity of thymocytes was diminished significantly in all animals older than 14 weeks. The ratio of the ADA-activities in splenocytes and thymocytes was 1:2 at the beginning of the investigations and 1:1 after 120 weeks.
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D005260:Female; D008214:Lymphocytes / Q000201:enzymology*; D051379:Mice; D008808:Mice, Inbred CBA; D009700:Nucleoside Deaminases / Q000378:metabolism*; D013154:Spleen / Q000166:cytology* / Q000201:enzymology; D013950:Thymus Gland / Q000166:cytology* / Q000201:enzymology
chemical_list: D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase
vernacular_title: Altersabhängigkeit der Adenosin-Deaminase-Aktivität in Lymphozyten aus Milz und Thymus der Maus.