[Radioprotective effectiveness of the paramunity inducer "pind-avi": investigation using the model "protective tetanic vaccination in mice" after exposure to X-rays (author's transl)].
The model "protective tetanic vaccination in mice" was used in order to try whether the paramunity inducer Pind-Avi may diminish or suspend radiation-induced immunosuppression. The radioprotective effect was ascertained from the different results of immunization in mice exposed to radiation after pretreatment with either Pind-Avi or placebo. The dose delivered amounted to 300 R. Tetanus toxoid was used for immunization. Effectiveness of the tetanic vaccination was analysed by means of load tests with 10 LD50 tetanus toxin, and of antibody determination with passive hemagglutination. Evidence was shown of significant radiation protection following subcutaneous application of Pind-Avi once a day during three days before of after exposure. Efficiency in mice treated with Pind-Avi amounted to 75% (pre-irradiation treatment) and to 43% (postirradiation treatment), whereas the efficiency in controls was zero in all cases. Thus, it was possible with Pind-Avi to suspend radiation-induced immunosuppression within a period of 3 days before or after radiation exposure, not only by means of prophylactic but also by therapeutic administration.
D000818:Animals; D014645:Herpesvirus 3, Human; D007165:Immunosuppression Therapy; D051379:Mice; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013742:Tetanus / Q000517:prevention & control*; D014611:Vaccination
D011837:Radiation-Protective Agents
Untersuchungen über eine Strahlenschutzwirkung des Paramunitätsinducers "Pind-Avi" am Modell "Tetanus-Schutzimpfung-Maus" nach Röntgenbestrahlung.