[Effect of an acidic sulfated polysaccharide on whole blood coagulability. In vivo study in rats].
Armatan, an acid sulphated polysaccharide isolated from a red marine seaweed Asparagopsis armata (Harv.), increases the coagulation time of the rat plasma in vivo assays. This property presents, with administration, time and dose, some variations. Among the three ways studied, subcutaneous injection gives more interesting results than the others. At high concentrations (10, 20 and 50 mg/kg), intravenous administration induces plasma and organic (liver-spleen) diseases.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014914:Whole Blood Coagulation Time
D011134:Polysaccharides; C028510:armatan
Action d'un polysaccharide sulfaté acide sur la coagulabilité globale du sang. Etude in vivo chez le rat.