Immunological modification of adriamycin cardiotoxicity.
Adriamycin-specific antibody has been shown to increase the survival of mice receiving an acute cardiotoxic dose of adriamycin. The concentrations of adriamycin in heart tissue were reduced and those in tumor elevated for more than 2 days in animals that received the antibody. The adriamycin-specific antibody prevented and reversed adriamycin inhibition of cardiac microsomal Na-K ATPase.
D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D004317:Doxorubicin / Q000276:immunology* / Q000633:toxicity; D006331:Heart Diseases / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008861:Microsomes / Q000201:enzymology; D009206:Myocardium / Q000648:ultrastructure; D011817:Rabbits / Q000276:immunology; D000254:Sodium-Potassium-Exchanging ATPase / Q000276:immunology
D000906:Antibodies; D004317:Doxorubicin; D000254:Sodium-Potassium-Exchanging ATPase