[Autoimmune hemolytic anemia followed by acute granulocytic leukemia (author's transl)].
The authors report a case of acute myeloid leukemia developing 5 years after the onset of an autoimmune hemolytic anemia. The cytological origin of the proliferation is difficult to assess: the presence of prominent membranous complexes and a strong positivity of acid phosphatase reaction favour its megacaryocytic origin. However the cytological evolution pleads for the development of successive clones of monocytic origin, may be modified by the treatment. Are the two diseases successive consequences of preexisting state of immunodepression or was such a state created by the autoimmune anemia?
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000201:enzymology / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008533:Megakaryocytes / Q000648:ultrastructure; D009000:Monocytes / Q000648:ultrastructure
Anémie hémolytique à auto-anticorps suivie d'une leucémie myéloïde aiguë.