The role of adjuvant therapy in Stage I ovarian cancer.
Women with Stage I epithelial carcinoma of the ovary were initially treated by an extirpative operation and were subsequently randomized to either no further treatment, radiotherapy, or chemotherapy. Only two patients (6%) treated with chemotherapy developed recurrence, compared to five (17%) and seven (30%) patients in the no-treatment and radiotherapy regimens, respectively (P < 0.05). All patients, with the possible exception of those with Stage IA(1)g1, appeared to benefit from adjuvant chemotherapy compared to no treatment or radiotherapy.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy; D002288:Adenocarcinoma, Mucinous / Q000628:therapy; D003536:Cystadenocarcinoma / Q000628:therapy; D004715:Endometriosis / Q000628:therapy; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy