Effects of prostaglandin D3 on nerve transmission in nictitating membrane of cats.
In anesthetized cats, intra-arterial injection of PGD3 toward the nictitating membrane caused long-lasting, dose-related decreases in the response of the nictitating membrane to sympathetic nerve stimulation. During peak depression of nerve transmission the response of the nictitating membrane to intra-arterial norepinephrine was not depressed suggesting that PGD3 suppressed the release of norepinephrine. PGD3 was as potent as PGD2 for modulating sympathetic nerve transmission but was less effective in activating a vagally mediated bradycardia. The results show that the PGD3 can modulate autonomic nerve transmission.
D000818:Animals; D002415:Cats; D006439:Hemodynamics / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009541:Nictitating Membrane / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology*; D011457:Prostaglandins D / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D011453:Prostaglandins; D011457:Prostaglandins D; C027005:prostaglandin D3