title: Bone cell cultures as an experimental model.
abstract: The isolation and separation of bone cells with populations enriched for osteoclastic or osteoblastic phenotypes are described. Such systems offer the opportunity to compare and contrast the controls exerted by hormones, ions, and other agents on the functions of the individual bone cell types and may in the future provide explanation for the changes seen in bone tissue in various diseased states.
mesh_terms: D001842:Bone and Bones / Q000166:cytology*; D002469:Cell Separation; D002478:Cells, Cultured; D004063:Digestion; D003012:Microbial Collagenase / Q000494:pharmacology; D008954:Models, Biological; D010006:Osteoblasts; D010010:Osteoclasts; D010641:Phenotype
chemical_list: D003012:Microbial Collagenase