Effect of metopirone on pituitary gland of male squirrel, Funambulus pennanti (Wroughton).
1. The ACTH cell type has been demonstrated for the first time in the hypophysis of the squirrels. These are large cells with homogenous cytoplasm and are more abundant in the anteromedian zone and in the peripheral portion than elsewhere. 2. A great hypertrophy and hyperplasia of the pituitary corticotrophs were observed in the experimental group at all the intervals. 3. Metopirone treated animals showed a moderate hypertrophy and degranulation of pituitary thyrotrophs. 4. By effect of metopirone, a marked regression of pituitary interstitiotrophs and total degranulation took place by 30 days treatment. The folliculotrophs did not show alterations.
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis; D000818:Animals; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis; D007986:Luteinizing Hormone / Q000096:biosynthesis; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D012589:Sciuridae / Q000033:anatomy & histology*; D013972:Thyrotropin / Q000096:biosynthesis
D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D008797:Metyrapone