Anti-dsDNA antibodies in sera of patients without systemic lupus erythematosus.
133 sera of patients without systemic lupus erythematosus (SLE) have been analyzed by an ultramicro ELISA for antibodies to dsDNA. 14 sera (10.5%) had antibody concentrations greater than 120 mU/ml ("positive"). Additionally, 29 sera (21.5%) had antibodies within the range 60 . . . 120 mU/ml ("borderline"). Pathogenetic significance is discussed briefly.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D003095:Collagen Diseases / Q000276:immunology; D004247:DNA / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
D000974:Antibodies, Antinuclear; D004247:DNA