Sixth Daniel C. Baker, Jr. Memorial Lecture, Induction of cancer by DNA viruses.
The life cycles of the tumor virus SV40 and polyoma are discussed with particular emphasis on the role of the viral coded proteins which mediate the transformation of normal cells into their cancerous equivalents. One of more of these proteins possibly act by stimulating directly the synthesis of cellular DNA, while others may mimic the action of polypeptide mitogens that act at the cell surface.
D000818:Animals; D002417:Cattle; D002472:Cell Transformation, Viral; D004261:DNA Replication; D004263:DNA Tumor Viruses / Q000254:growth & development*; D005814:Genes, Viral; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D010212:Papilloma / Q000209:etiology; D013539:Simian virus 40 / Q000235:genetics / Q000254:growth & development / Q000276:immunology