title: [Digestive localization of generalized amyloidosis: attempt of differentiation of "primary" and "secondary" amyloidosis (author's transl)].
abstract: The aim of this study is to precise topography of amyloid deposits in the alimentary tract and to differenciate the primary or secondary nature of amyloid substance according to these topographical data and with the help of the Wright's technic. The material of this study consists in nine necropsies and seventeen digestive biopsies, concerning patients with generalized amyloidosis. Immunoglobulinic amyloidoses (so-called "primary") contain predominating deposits in the muscularis propria which remain after Wright's technic. On the other hand, in the non-immunoglobulinic amyloidoses (so-called "secondary"), deposits are essentially localized in the mucosa and disappear (more than 80%) after Wright's technic. Moreover, some special cases, as Portugese amyloidosis and amyloidosis in the course of Crohn's disease, are studied. In the first case, the immunoglobulinic nature of amyloidosis seems to be very likely. In Crohn's disease, in one case, the classical notion of non-immunoglobulinic amyloidosis is confirmed, while, in another one, the amyloidosis is much likely an immunoglobulinic one, and that is a new fact. The authors insist on the practical aspect of this study: it is usually possible to precise the nature of the amyloid deposit on digestive biopsy and so, to give indications to the clinicians about an etiological group.
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D001344:Autopsy; D001706:Biopsy; D003937:Diagnosis, Differential; D004064:Digestive System / Q000473:pathology*; D006801:Humans
vernacular_title: Localisation digestive de l'amylose généralisée: tentative de différenciation de l'amylose "primitive" et "secondaire".