title: Severe skin necrosis produced by piperazinedione extravasation.
mesh_terms: D000671:Amputation, Surgical; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001132:Arm / Q000601:surgery; D003646:Debridement; D062109:Dermatologic Surgical Procedures; D005909:Glioblastoma / Q000188:drug therapy; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced* / Q000601:surgery; D010879:Piperazines / Q000009:adverse effects*; D012867:Skin / Q000187:drug effects* / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D010879:Piperazines; C003905:3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione