Increased incidence of IgM class smooth muscle antibody in patients after renal transplantation.
Autoantibodies were examined in 70 patients with renal failure, before acceptance on a hemodialysis program, during the program, and up to 3 months after renal transplantation. Smooth muscle antibody (SMA) in the IgM class was detected in 76% of the patients after transplantation compared with 14% before transplantation. This increase was significant at the 5% level. Furthermore, two groups of patients were distinguished on the basis of a 4-fold or greater increase or no demonstrable increase in the titer of IgM SMA after transplantation. Rejection episodes occurred more frequently amongst patients from this former group (67%) compared with the latter group (35%).
D000328:Adult; D000818:Animals; D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral / Q000096:biosynthesis; D000961:Antilymphocyte Serum; D001323:Autoantibodies / Q000096:biosynthesis; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D009130:Muscle, Smooth / Q000276:immunology*; D051381:Rats; D006435:Renal Dialysis; D013997:Time Factors
D000974:Antibodies, Antinuclear; D000914:Antibodies, Viral; D000961:Antilymphocyte Serum; D001323:Autoantibodies; D006680:HLA Antigens; D007075:Immunoglobulin M