"Half-site" affinity modification of tryptophanyl-tRNA synthetase leads to "freezing" of the free subunit.
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000345:Affinity Labels / Q000494:pharmacology*; D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors*; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002417:Cattle; D011756:Diphosphates / Q000378:metabolism; D007700:Kinetics; D046911:Macromolecular Substances; D010179:Pancreas / Q000201:enzymology; D014364:Tryptophan / Q000031:analogs & derivatives / Q000378:metabolism; D014369:Tryptophan-tRNA Ligase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000345:Affinity Labels; D011756:Diphosphates; D046911:Macromolecular Substances; C022179:tryptophyl adenylate; D000249:Adenosine Monophosphate; C029889:mesitoyl-AMP; D014364:Tryptophan; D000255:Adenosine Triphosphate; D000604:Amino Acyl-tRNA Synthetases; D014369:Tryptophan-tRNA Ligase