Susceptibility of monkeys to human hepatitis A virus.
A stump-tailed monkey, newly caught and without antibody to hepatitis B virus (HAV), was successfully infected with human HAV. The following alterations were observed in the monkey's functions: (1) elevation in activities of serum glutamic pyruvic transaminase, lactate dehydrogenase, and its type 5 isoenzyme (electrophoretically the fastest moving); (2) development of antibody to HAV; and (3) shedding of HAV antigen in feces. The virus isolated from the monkey, designated the Hangzhou A-1A strain of HAV, was serially transmitted to two other stump-tailed monkeys. Thus, the stump-tailed monkey (Macaca speciosa) is susceptible to infection with human HAV.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004198:Disease Susceptibility; D006506:Hepatitis A / Q000635:transmission* / Q000662:veterinary; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008251:Macaca / Q000382:microbiology; D008992:Monkey Diseases; D000637:Transaminases / Q000378:metabolism
D000914:Antibodies, Viral; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D000637:Transaminases