title: [Substances with antiviral activity. XV. Preparation and antiherpes activity of alkyl- and acylamino-dihalogenated pyrimidines and pyridines].
abstract: Some dihalo-amino-pyrimidines and -pyridines were alkylated and acylated at the amino group. The resulting twenty-four compounds were then tested for their action on Herpes simplex virus infection in human HEp-2 cell cultures. Five compounds were active and 2-benzamido-3,5-dichloropyridine [(III B); Table I] showed the highest antiviral activity.
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011725:Pyridines; D011743:Pyrimidines
vernacular_title: Ricerche su sostanze ad attività antivirale. Nota XV - Preparazione e attività antierpetica di alchil- e acilammino- -dialogeno-pirimide e -piridine.