[Beta-adrenergic receptors and paradoxical sleep in the rat].
Treatment of adult rats with a beta-adrenergic blocking agent (propranolol) induced a paradoxical sleep deficit which was dose-related. This deficit could be completely corrected by intraventricular perfusion with a beta-agonist (isoproterenol), according to a dose-dependent function. The beta-adrenergic receptors may therefore be specifically involved in the regulation of paradoxical sleep.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D007545:Isoproterenol
Récepteurs beta-adrénergiques et sommeil paradoxal chez le Rat.