[Study of the diagnostic significance of the serum IgE level in patients with bronchial asthma].
The serum level of IgE was determined in 59 patients (of whom 36 had atopic asthma, 15 had non-atopic asthma, and 8 had various other pneumopathies with a bronchospastic component). A radioimmunological method was used. The data obtained show that the average values for IgE are high in atopic asthma (796 +/- 161 I.U. per ml). The highest values were of 4.000 I.U. per ml. The average value is clearly different from that found in non-atopic asthmatic patients (185 +/- 30 I.U. per ml), as well as from that recorded in the other patients (260 +/- 76 I.U. per ml), an indication that an assay of the serum level of the type of bronchial asthma. With regard to the di-sodium cromoglycate treatment it was demonstrated that this does not produce signficant changes in the concentration of serum IgE, and it is not possible to foresee, on the basis of the initial level of reagins, what the results of the application of this drug will ultimately be.
D001249:Asthma / Q000175:diagnosis / Q000276:immunology*; D001986:Bronchial Spasm / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*
D007073:Immunoglobulin E
Studiu privitor la semnificaţia diagnostică, a nivelului seric al IgE la bolnavii cu astm bronşic.