Characterization of virus produced by a lymphoma induced by inoculation of AKR MCF-247 virus.
We report the characterization of the virus produced by a lymphoid cell line derived from a lymphoma of an AKR mouse after injection of the polytropic AKR virus MCF-247. The virus displays polytropic host range properties and is indistinguishable from MCF-247 as judged by analysis of the large RNase T1-resistant oligonucleotides of the RNA genome. Restriction enzyme analysis of cellular DNA revealed the presence of sequences homologous to MCF-247 genomic RNA. The EcoRI cleavage fragments were characteristic of MCF-247 DNA provirus cleavage products.
D000406:AKR murine leukemia virus / Q000235:genetics*; D000818:Animals; D004247:DNA / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008223:Lymphoma / Q000382:microbiology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D009374:Neoplasms, Experimental / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis; D006163:Ribonuclease T1
D012367:RNA, Viral; D004247:DNA; D006163:Ribonuclease T1