Dihydropteridine-reductase activity in breast cancer. Preliminary report.
The dihydropteridine-reductase activity was measured in 206 breast cancers. Large variations were found: 6% of tumors showing high values closed to those noted in liver, whereas the main group has activities of same magnitude of that in cultured fibroblasts. Significant correlation appeared between dihydropteridine-reductase activities and hormonal dependence, as measured by cytosolic estrogen receptor sites.
D001943:Breast Neoplasms / Q000201:enzymology*; D003600:Cytosol / Q000378:metabolism; D004093:Dihydropteridine Reductase / Q000378:metabolism*; D005260:Female; D006801:Humans; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism
D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen; D004093:Dihydropteridine Reductase; D009247:NADH, NADPH Oxidoreductases