Selective synaptic antagonism by atropine and alpha-aminoadipate of pulvinar and cortical afferents to the suprasylvian visual area (Clare-Bishop area).
The synaptic excitations of cells of the Clare-Bishop cortical region produced by electrical stimulation of the pulvinar and ipsilateral cortex, have been shown to be differentially antagonized by iontophoretically applied antagonists. Atropine attenuated the responses evoked by pulvinar stimulation without having an appreciable effect against either iontophoretically applied aspartate or cortically evoked responses. alpha-Aminoadipate antagonized aspartate elicited excitations and those obtained with cortical stimulation while leaving unaffected acetylcholine and pulvinar evoked responses. The results are supportive of the view that acetylcholine and aspartate, or a similar excitatory amino acid, act as synaptic transmitters of some afferents from the pulvinar and ipsilateral cerebral cortex, respectively.
D015074:2-Aminoadipic Acid / Q000494:pharmacology*; D000109:Acetylcholine / Q000494:pharmacology; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology*; D002415:Cats; D002535:Cerebral Aqueduct / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D004292:Dominance, Cerebral / Q000187:drug effects; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects; D010775:Photic Stimulation; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D013787:Thalamic Nuclei / Q000187:drug effects*; D014795:Visual Pathways / Q000187:drug effects
D000600:Amino Acids, Dicarboxylic; D015074:2-Aminoadipic Acid; D001224:Aspartic Acid; D001285:Atropine; D000109:Acetylcholine