title: [Effect of collagenase on the permeability of the glomerular basement membrane in the rat kidney].
abstract: Recently, several authors have emphasized the role of negative sites located in th laminae rarae of the glomerular basement membrane (GBM), in restricting glomerular permeability to anionic macromolecules. In this work, we point out that ultrafiltration properties involve integrity of the GBM. Indeed after intravenous perfusion of bacterian collagenase, anionic ferritin permeates the GBM though negative site distribution (as shown by fixation of colloidal iron) is unaffected.
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000648:ultrastructure; D003012:Microbial Collagenase / Q000494:pharmacology*; D051381:Rats
chemical_list: D003012:Microbial Collagenase
vernacular_title: Action de la collagénase sur la perméabilite de la membrane basale glomérulaire du rein de rat.