[Cyclic 3,5-adenosine monophosphate content and calcium transport in the aorta in hypertension due to experimental renal insufficiency].
The calcium, magnesium, and cyclic AMP content and 45Ca transport in the aorta and iliac artery and the mechanical properties of these vessels were studied in rats with experimental renal insufficiency. The development of hypertension was attended by an increase in the magnesium content in the vascular wall, a certain decrease in the cyclic AMP level, marked disturbance of 45Ca transport, and changes in the mechanical properties of the vascular wall. The use of dihydrotachysterol or a complex of sex steroids which correct calcium metabolism led to a decrease of arterial hypertension. It is suggested that disorder of calcium metabolism in chronic renal insufficiency plays an essential role in the inadequate regulation of the vascular tone and the development of hypertension.
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001692:Biological Transport; D001696:Biomechanical Phenomena; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006973:Hypertension / Q000209:etiology / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D009392:Nephrectomy; D051381:Rats; D014655:Vascular Resistance
D000242:Cyclic AMP; D008274:Magnesium; D002118:Calcium
Soderzhanie tsiklicheskogo 3,5-adenozinmonofosfata i transport kal'tsiia v aorte pri gipertenzii, obuslovlennoĭ éksperimental'noĭ pochechnoĭ nedostatochnosti.