Single-dose treatment of uncomplicated gonorrhea in men with intramuscular and oral thiamphenicol.
Each of 200 men with uncomplicated gonococcal urethritis was randomly assigned to a group receiving one of two therapeutic regimens. Group A received 2 g of spectinomycin intramuscularly. Group B received 2.5 g of thiamphenicol, with 500 mg administered intramuscularly just after oral administration of 2 g. Of the 89 patients in group A who completed the study, 32 were infected with penicillinase-producing Neisseria gonorrhoeae, 49 with non-penicillinase-producing N. gonorrhoeae, and eight with gonococcal strains not tested for penicillinase production. Infection was cured in all 89 patients. Of the 91 patients in group B who completed the study, 33 were infected with penicillinase-producing N. gonorrhoeae, 54 with non-penicillinase-producing N. gonorrhoeae, and four with gonococcal strains not tested for penicillinase production. Infection was cured in 86 (94.5%) of the 91 patients. Thus, the single-dose regimen of thiamphenicol was effective against uncomplicated infections caused by either penicillinase-producing or non-penicillinase-producing strains of N. gonorrhoeae.
D000284:Administration, Oral; D004341:Drug Evaluation; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology; D010405:Penicillinase / Q000096:biosynthesis; D011897:Random Allocation; D000198:Spectinomycin / Q000008:administration & dosage; D013839:Thiamphenicol / Q000008:administration & dosage*
D000198:Spectinomycin; D010405:Penicillinase; D013839:Thiamphenicol