Increase in pituitary melanocyte-stimulating hormone activity of genetically obese (ob/ob) mice.
Melanocyte-stimulating hormone (MSH) activity was measured in the pituitaries of genetically obese and lean control mice using the frog skin bioassay. Obese mice pituitaries demonstrated very significantly elevated levels of biologically active MSH when compared to their lean littermates. These results support the hypothesis that the elevated levels of pituitary hormones found in obese mice possesses true biological activity.
D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000818:Animals; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis*; D051379:Mice; D008820:Mice, Obese / Q000378:metabolism*; D010902:Pituitary Gland / Q000032:analysis*
D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones