A x C rat prostate adenocarcinoma: initial characterization of testosterone regulation of hormone receptors of cultured cancer cells and derived tumors.
A x C rat prostate cancer cells were established in continuous culture. The polygonal epithelial cells had granular cytoplasm and well-defined cell margins, contained round to oval nuclei with prominent nucleoli, and were tumorigenic when inoculated into A x C male rats. The tumors produced by the injected prostate cancer cells grew as well-vascularized, solid, cribriform adenocarcinomas. The rat prostate cancer cells and derived tumors contained cytoplasmic and nuclear androgen receptors and prolactin receptors. Androgen regulation of prolactin receptor content and androgen receptor distribution in A x C rat prostate cancer cells were comparable to those of the normal ventral prostate gland. These studies suggest that the A x C rat prostate cancer cells and tumors may represent a unique model for studies of hormonal regulation of prostate cancer cell behavior.
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002369:Castration; D002467:Cell Nucleus / Q000032:analysis; D002478:Cells, Cultured; D003593:Cytoplasm / Q000032:analysis; D008297:Male; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D011944:Receptors, Androgen / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011981:Receptors, Prolactin; D011987:Receptors, Steroid / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*
D011944:Receptors, Androgen; D011956:Receptors, Cell Surface; D011981:Receptors, Prolactin; D011987:Receptors, Steroid; D013739:Testosterone