Effect of low dose irradiation on renal enlargement in children following nephrectomy for Wilms' tumor.
The effect of low dose irradiation on subsequent compensatory renal enlargement in a group of children operated upon with unilateral nephrectomy for Wilms' tumor is reported. Comparison groups were children whose remaining kidney received either no direct irradiation or irradiation to only the upper portion of the kidney. The rate of growth of the kidney in the irradiated group was slightly less but this was not statistically significant. Thus, radiation therapy in children with Wilms' tumor, so crucial to optimum survival, does not seem to cause significant renal toxicity.
D002648:Child; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D006801:Humans; D007668:Kidney / Q000503:physiopathology / Q000528:radiation effects*; D007680:Kidney Neoplasms / Q000532:radiotherapy*; D009392:Nephrectomy; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D009396:Wilms Tumor / Q000532:radiotherapy*
D003037:Cobalt Radioisotopes