Possible beneficial effect of high-dose intravenous steroid therapy in acute demyelinating disease and transverse myelitis.
Intravenous steroid followed by oral prednisone was administered to patients with Guillain-Barré syndrome (five), acute transverse myelitis (three), and multiple sclerosis in acute relapse (seven). Preliminary experience with each of these disorders revealed prompt clinical improvement in some patients. The approach used in this uncontrolled study deserves further investigation.
D000208:Acute Disease; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage* / Q000627:therapeutic use; D000328:Adult; D003711:Demyelinating Diseases / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000188:drug therapy; D009187:Myelitis / Q000188:drug therapy*; D009188:Myelitis, Transverse / Q000188:drug therapy*; D011129:Polyradiculoneuropathy / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
D000324:Adrenocorticotropic Hormone; D011241:Prednisone; D008775:Methylprednisolone