Norepinephrine uptake in aging adrenergic nerve terminals.
Norepinephrine (NE) uptake has been studied in the adult (3-6 months) and aging (5 yr) chick iris, in which there is a discrete population of norepinephrine containing nerve terminals. although total accumulation of 3H-NE in the iris does not change with age, there is a decline in Na+-dependence, temperature-sensitivity, ouabain-and inhibitor -sensitivity of uptake. The results indicate either a loss of active, carrier-mediated NE uptake during aging, or a change in the biochemical and pharmacological characteristics of this uptake. changes in the composition of the organ and in the sites of accumulation of NE are considered.
D000375:Aging; D000818:Animals; D002645:Chickens; D003891:Desipramine / Q000494:pharmacology; D005260:Female; D007498:Iris / Q000294:innervation*; D008297:Male; D008676:Metanephrine / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology
D011941:Receptors, Adrenergic; D008676:Metanephrine; D010042:Ouabain; D012964:Sodium; D003891:Desipramine; D009638:Norepinephrine