Immunological parameters in gestational trophoblastic neoplasia.
Immunological function were studied in 22 patients with hydatidiform mole and 29 patients with malignant trophoblastic disease before and after treatment; normal pregnant and post-pregnant women served as controls. The only significant abnormality in hydatidiform mole was a low granulocyte chemotaxis before evacuation. In malignant trophoblastic disease the total lymphocyte counts, T-cell counts. B-cell counts, lymphocyte responses to mitogens and serum IgA levels were significantly lower than in normal women 6 wk after pregnancy. In those who responded to chemotherapy, these indices rose to the levels of post-pregnancy controls. An 'immune profile score' based on these indices was found to be a useful prognostic index. All patients with hydatidiform mole who had a score of 7 or less developed malignant trophoblastic disease, while the two patients with malignant trophoblastic disease who died had the lowest scores of the series.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes; D002634:Chemotaxis, Leukocyte; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000276:immunology*; D007136:Immunoglobulins; D007958:Leukocyte Count; D008727:Methotrexate / Q000627:therapeutic use; D008934:Mitogens / Q000494:pharmacology; D011247:Pregnancy; D012882:Skin Tests; D013601:T-Lymphocytes; D014328:Trophoblastic Neoplasms / Q000188:drug therapy / Q000276:immunology*; D014594:Uterine Neoplasms / Q000276:immunology*
D007136:Immunoglobulins; D008934:Mitogens; D008727:Methotrexate