title: Semi-synthetic analogs of cytochrome c. Substitutions for methionine at position 80.
abstract: Derivatives of cytochrome c having S-methyl cysteine and ethionine substituted for methionine residue 80 have been synthesized in order to study the effects of structural perturbations near the heme on the biological function of cytochrome c. The etionine derivative has 96% as much activity as native cytochrome c in the succinate oxidase system, whereas the S-methyl cysteine analog is totally inactive.
mesh_terms: D003488:Cyanogen Bromide; D003545:Cysteine / Q000031:analogs & derivatives; D003574:Cytochrome c Group; D005001:Ethionine; D006418:Heme; D008715:Methionine; D010088:Oxidoreductases / Q000378:metabolism; D013329:Structure-Activity Relationship; D013386:Succinates / Q000378:metabolism
chemical_list: D003574:Cytochrome c Group; D013386:Succinates; D006418:Heme; C008425:S-methylcysteine; D008715:Methionine; D010088:Oxidoreductases; C022691:succinate oxidase; D003545:Cysteine; D003488:Cyanogen Bromide; D005001:Ethionine