Lymphocyte cyclic nucleotide and prostaglandin content in psoriasis: a preliminary report.
Lymphocytes from psoriatic patients were found to contain reduced levels of adenosine 3':5'-cyclic phosphate, guanosine 5'-cyclic phosphoric acid, and prostaglandin E, as compared with lymphocytes from normal subjects. The difference in prostaglandin F levels between psoriatic and control subjects was not statistically significant. These results could point to an immunologic defect in the immune system in psoriasis.
D000328:Adult; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism*; D011565:Psoriasis / Q000097:blood / Q000276:immunology*
D011458:Prostaglandins E; D000242:Cyclic AMP; D006152:Cyclic GMP