Hindbrain GABA receptors influence parasympathetic outflow to the stomach.
Blockade of gamma-aminobutyric acid receptor function by direct microinjection of bicuculline into the nucleus ambiguous in cats produced a marked increase in gastric motility which was mediated by the vagus nerve. This effect was reversed by muscimol. These data indicate that the nucleus ambiguous may be an important brain site influencing gastric function and that the neurotransmitter controlling parasympathetic overflow from this nucleus to the stomach is gamma-aminobutyric acid.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D005769:Gastrointestinal Motility / Q000187:drug effects; D008526:Medulla Oblongata / Q000502:physiology*; D009118:Muscimol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D013270:Stomach / Q000294:innervation* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline