[Effects of cefotaxime on the intestinal bacterial ecosystem in children (author's transl)].
Cefotaxime activity was studied in pediatric practice on the intestinal bacteria flora of 10 children, by means of a differential quantitative method for aerobic and anaerobic faecal flora and was compared to that of 41 controls not receiving any antibiotics. Cefotaxime was given alone in 7 children, and in combination with gentamicin in 3. An effect on the intestinal bacterial flora was noted on E. coli, which disappeared in 4 cases and diminished considerably in 5. A slight increase in Streptococcus D was observed without excessive multiplication of the flora. The study showed no significant alteration for the other aerobic or anaerobic bacilli. There was no selection of resistant organisms. Cefotaxime is a new cephalosporin which does not seem to produce an increase in many resistant pathogens due to a break-down of the barrier effect observed on the bacterial flora of the gut in children.
D002439:Cefotaxime; D002511:Cephalosporins / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005243:Feces / Q000382:microbiology; D006801:Humans; D007223:Infant; D007422:Intestines / Q000382:microbiology*
D002511:Cephalosporins; D002439:Cefotaxime
Effets du céfotaxime sur l'écosystème bactérien intestinal de l'enfant.