title: [Experimental amebiasis: effect of PGE1 on rats infested with Entamoeba histolytica].
abstract: The authors have studied the effects of PGE1 on rats (Wistar strain) infected with Entamoeba histolytica, and inoculated with PGE1 either in massive dosage and killed after 3-5 and 7 days, or with daily minimum quantity of PGE1 and killed on days 7 and 15 after inoculation. The results show an inhibition effect of PGE1 on development and survival of amoebae in the coecum of rats inoculated with the two modalities described above. The fractionated dosage gives better results and less side effects.
mesh_terms: D000818:Animals; D004404:Dysentery, Amebic / Q000188:drug therapy* / Q000473:pathology; D004748:Entamoeba histolytica / Q000187:drug effects; D007422:Intestines / Q000473:pathology; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
chemical_list: D011459:Prostaglandins E, Synthetic
vernacular_title: Amebiasi sperimentale: azione delle PGE1 su ratti infestati con "Entamoeba histolytica".