[Cineradiological study of the activity of sorbiperan on the gallbladder and colon (author's transl)].
The activity of sorbiperan was assessed during radiological examinations of 15 patients with hypomobility of the gallbladder, associated in some cases with atonic dyspepsia, and 25 cases of spastic colon with constipation and/or diarrhea due to diverticulosis, dolichocolon, sigmoiditis, or parasitosis. Patients with gallbladder dysfunction were examined radiologically before and after oral administration of 20 to 40 ml of sorbiperan, the dose varying as a function of bodyweight. In 3 patients, the hypermobility of the gallbladder provoked by this agent was greater than that observed with all usually employed products, in 11 cases the cholagogue produced an excellent effect, while in one case there was no observed effect. Patients with colitis were administered a barium enemea, and an initial series of films were taken. These were repeated after addition of 80 ml of sorbiperan to the same enema. Total, rapid evacuation of the colon was observed in 8 cases, while in 15 cases it was of excellent quality. No effect was noted in 2 cases. Sorbiperan provokes effective contractions of the gallbladder, favours sphincter of Oddi dynamics, increases motility of all digestive tract segments, and very significantly accelerates gastro-entero-colic peristalsis. Tolerance was excellent.
D000328:Adult; D000368:Aged; D001659:Biliary Tract / Q000187:drug effects; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging; D002933:Cineradiography; D003106:Colon / Q000187:drug effects*; D004338:Drug Combinations; D004761:Enterocolitis, Pseudomembranous / Q000000981:diagnostic imaging; D005260:Female; D005704:Gallbladder / Q000187:drug effects*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D013012:Sorbitol / Q000494:pharmacology*
D004338:Drug Combinations; D013012:Sorbitol; D008787:Metoclopramide
Evaluation ciné-radiologique de l'activité du sorbipéran sur la vésicule biliaire et le côlon.