Hormonal responses to long-term converting enzyme inhibition in hypertensive patients.
Captopril was given alone and in combination with diuretics to 49 patients with hypertension for 1 to 12 mol Within 2 mo blood pressure reduction correlated with pretreatment plasma renin activity and response to the infusion of angiotensin II antagonist, but these effects were not present at 4 mo. Plasma and urinary aldosterone were suppressed but serum converting enzyme activity, plasma bradykinin, kallikren, and prostaglandins (E and F) were in the normal range effect of captopril. Despite sustained reduction of blood pressure, plasma catecholamines were not elevated and urinary catecholamines were suppressed in patients on captopril alone. It is concluded that another mechanism, such as enhancement of renal or local kinin-prostaglandin system, as well as suppression of the renin-angiotensin-aldosterone system may be involved in the long-term efficacy of captopril. Sympathetic activity may also be depressed and contribute to the hypotensive effect.
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D002395:Catecholamines / Q000097:blood / Q000652:urine; D002648:Child; D004232:Diuretics / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007213:Indomethacin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011392:Proline / Q000031:analogs & derivatives*; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects; D013997:Time Factors; D000092502:Renin Inhibitors
D000450:Aldosterone; D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril; D002395:Catecholamines; D004232:Diuretics; D007213:Indomethacin; D000451:Mineralocorticoid Receptor Antagonists; D007703:Peptidyl-Dipeptidase A; D011392:Proline; D012083:Renin; D000092502:Renin Inhibitors