[Effect of manganese ions and verapamil on electrogenesis and contraction of ureter smooth muscle].
Fast and slow calcium channels of the electrically excitable membrane of the ureter smooth muscle cells had different sensitivity to manganese ions and verapamil. Manganese ions (10(-4) M) selectively blocked the fast potential--dependent Ca--channels, Ca ions being necessary for phasic contraction, whereas verapamil (10(-9)--10(-8)) specifically blocked the slow potential--dependent CA--channels.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008345:Manganese / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects*; D014513:Ureter / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D007473:Ion Channels; D008345:Manganese; D014700:Verapamil; D002118:Calcium
Deĭstvie ionov margantsa i verapamila na élektrogenez i sokrashchenie v gladkikh myshtsakh mochetochnika.