Tc-99m HMDP (hydroxymethylene diphosphonate): a radiopharmaceutical for skeletal and acute myocardial infarct imaging. II. Comparison of Tc-99m hydroxymethylene diphosphonate (HMDP) with other technetium-labeled bone-imaging agents in a canine model.
Technetium-99m hydroxymethylene diphosphate (Tc-HMDP) was compared with the two other diphosphonates (Tc-MDP and Tc-HEDP) and Tc-99m pyrophosphate (Tc-PPi) in a canine model of acute myocardial infarction. The TC-HMDP showed higher uptake in infarcted myocardium than the other two diphosphonates, and uptake equivalent to that of Tc-PPi.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D011756:Diphosphates / Q000378:metabolism; D004164:Diphosphonates / Q000378:metabolism; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D012968:Etidronic Acid / Q000378:metabolism; D005269:Femur / Q000378:metabolism; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000378:metabolism; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D012272:Ribs / Q000378:metabolism; D013667:Technetium / Q000378:metabolism; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives; D016698:Technetium Tc 99m Pyrophosphate; D014018:Tissue Distribution
D011756:Diphosphates; D004164:Diphosphonates; D015609:Organotechnetium Compounds; C019561:technetium Tc 99m etidronate; D016698:Technetium Tc 99m Pyrophosphate; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013667:Technetium; D012968:Etidronic Acid; D013669:Technetium Tc 99m Medronate