Na+,K+-ATPase in developing rat brain during undernutrition.
Na+,K+-ATPase was studied in developing rat brain during undernutrition. The activity of Na+,K+-ATPase was significantly lower in animals that were undernourished from 6 to 17 days after birth than in well-nourished controls. The decreased activity of the enzyme was partially recovered after 4 weeks of rehabilitation. No change in the cation contents of brain following undernutrition was observed. The decrease in Na+,K4-ATPase activity was possibly due to the reduction in cholesterol contents and could be responsible for the observed functional changes associated with malnutrition or undernutrition during development.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D003677:Deficiency Diseases / Q000201:enzymology*; D005260:Female; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D010042:Ouabain; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium