Induced latency in pseudorabies vaccinated pigs.
A latent pseudorabies virus infection was established in pigs despite vaccination with a modified-live pseudorabies virus vaccine. Although the vaccinated pigs developed high concentrations of antibody, virus was recovered from the tonsils and lungs of pigs treated with dexamethasone three months after inoculation with virulent virus. These results may explain why vaccination programs have failed to eliminate the persistence and spread of virulent pseudorabies virus in infected herds.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D011558:Herpesvirus 1, Suid / Q000302:isolation & purification; D008297:Male; D014066:Palatine Tonsil / Q000382:microbiology; D011557:Pseudorabies / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D013552:Swine / Q000276:immunology*; D013553:Swine Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D014611:Vaccination / Q000662:veterinary*
D003907:Dexamethasone