Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.
Epidermal growth factor and fibroblast growth factor inhibited follicle-stimulating hormone-dependent induction of luteinizing hormone receptor in cultured ovarian granulosa cells of the rat. In contrast, platelet-derived growth factor potentiated the induction of luteinizing hormone receptor by follicle-stimulating hormone. These results indicate that growth factors, well known for their effects on mitosis and DNA synthesis in cultured mammalian cells, are also able to modulate hormone-dependent differentiation in an endocrine target cell.
D004092:20-alpha-Dihydroprogesterone / Q000378:metabolism; D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D006063:Chorionic Gonadotropin / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D006107:Granulosa Cells / Q000378:metabolism*; D006133:Growth Substances / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011966:Receptors, LHRH
D006063:Chorionic Gonadotropin; D006133:Growth Substances; D010455:Peptides; D011956:Receptors, Cell Surface; D011966:Receptors, LHRH; D004092:20-alpha-Dihydroprogesterone; D004815:Epidermal Growth Factor; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone