Cushing's syndrome due to an ACTH-secreting adrenal medullary tumour.
A 35-year-old man with Cushing's syndrome due to ectopic ACTH production is described. The six-week history and severe proximal myopathy were highly suggestive of a malignant tumour, but a solitary phaeochromocytoma of the left adrenal gland was the source of ACTH production. The surgical outcome was successful and three months post-operatively the hypothalamic-pituitary-adrenal axis was normal. At 12 months follow-up he remains well with complete regression of the features of Cushing's syndrome.
D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000313:Adrenal Medulla; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D003480:Cushing Syndrome / Q000209:etiology*; D006729:Hormones, Ectopic / Q000097:blood; D006801:Humans; D008297:Male; D010673:Pheochromocytoma / Q000473:pathology*
D006729:Hormones, Ectopic; D000324:Adrenocorticotropic Hormone