Clinical experience with a new steroid muscle relaxant: pipecurium bromide.
Experience gained in applying to 102 surgery patients a steroid muscle relaxant 2 beta,16 beta-bis-(4'-dimethyl-1'-piperazino)-3 alpha,17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, RGH 1106, Arduan) is reported. Pipercurium bromide proved to be a potent muscle relaxant with a medium duration of action. It can successfully be applied for intubation. Residual relaxation can be antagonized with neostigmine. Pipecurium bromide did not influence circulation, is free of side effects and can be applied in anaesthesiologically high-risk patients.
D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D000732:Androstanols / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D000931:Antidotes; D001835:Body Weight; D006801:Humans; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors; D017300:Pipecuronium; D010879:Piperazines / Q000037:antagonists & inhibitors; D011229:Preanesthetic Medication; D013997:Time Factors
D000732:Androstanols; D000931:Antidotes; D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol