title: Effects of dietary fibre on serum lipid levels and fecal bile acid excretion.
abstract: Epidemiologic studies have suggested that dietary fibre protects humans against coronary heart disease, but interpretation of the data is confounded by coexisting differences in both dietary and environmental variables. The hypocholesterolemic action of dietary fibre varies: in general mucilaginous fibres such as pectin and oat bran are more effective than particulate fibres such as wheat bran. Although the mechanism of action of mucilaginous fibres is not completely understood, there is evidence that they induce small increases in the fecal excretion of bile acids and neutral steroids that are not fully compensated for by de novo cholesterol synthesis.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D002482:Cellulose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000517:prevention & control; D004041:Dietary Fats; D004043:Dietary Fiber / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D006801:Humans; D007408:Intestinal Absorption; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D051381:Rats; D013256:Steroids / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber; D008074:Lipoproteins; D013256:Steroids; D014280:Triglycerides; D002482:Cellulose; D002784:Cholesterol