Effect of dibutyryl cyclic adenosine 3'5'-monophosphate on mitotic activity in the thyroid of hypophysectomized rats.
Effect of dibutyryl cyclic adenosine 3'5'-monophosphate (dbcAMP) on mitotic activity in the thyroid of hypophysectomized rats has been examined. It has been demonstrated that dbcAMP stimulates the incidence of mitoses in the thyroid follicular cells. It is therefore suggested that cAMP may be a mediator of the proliferogenic effect of TSH on the thyroid in vivo. Cyclic AMP could also release some unidentified growth-promoting factors for the thyroid. A direct stimulating effect of dbcAMP on the proliferation of the thyroid follicular cells is assumed to be possible as well.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D007016:Hypophysectomy; D008938:Mitosis / Q000187:drug effects*; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology
D003994:Bucladesine