The effects of epidermal growth factor on the cyclic nucleotide system in pig epidermis.
Incubation of pig skin slices with epidermal growth factor (EGF) caused an increase in intracellular cyclic GMP concentration. A significant increase was found after 1 hr of incubation and reached a peak by 6 hr. EGF caused no change in the cyclic AMP level nor did it affect epinephrine-induced cyclic AMP responses.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D066298:In Vitro Techniques; D010455:Peptides / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D013552:Swine
D010455:Peptides; D004815:Epidermal Growth Factor; D000242:Cyclic AMP; D006152:Cyclic GMP