[Corticosteriod regulation of Na, K-ATPase and ion transport in diverse zones of rat kidney].
Effect of corticosteroids on the activity of transport Na, K-ATP-ase and on the content of Na and potassium ions in various zones of the kidneys in rats with removed adrenal glands was studied. Adrenalectomy diminished the activity of Na, K-ATP-ase and Na level considerably; the greatest changes were observed in the medullary and the papillary zones of the kidneys. Aldosterone administration increased the Na content in the medullary and papillary zones, but failed to influence the enzymatic activity. DOCA injections caused an increase in the enzymatic activity and normalized the Na content in the medullary and papillary zones of the kidneys. Hydrocortisone therapy restored the Na, K-ATP-ase activity in the cortical and the medullary zones. On the basis of the data obtained a conclusion was drawn that both minerals and glucocorticoids took part in the regulation of the transport processes through the membranes of the renal tubules, but influenced different areas of the nephron.
D000315:Adrenalectomy; D000450:Aldosterone / Q000627:therapeutic use*; D000818:Animals; D003900:Desoxycorticosterone / Q000627:therapeutic use*; D006728:Hormones / Q000627:therapeutic use; D006854:Hydrocortisone / Q000627:therapeutic use*; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D007686:Kidney Tubules, Distal / Q000378:metabolism; D008297:Male; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D006728:Hormones; D003900:Desoxycorticosterone; D000450:Aldosterone; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D006854:Hydrocortisone
Kortikosteroidnaia reguliatsiia Na, K-ATF-azy i transporta ionov v raznykh zonakh pochki krysy.