Effect of indomethacin on cardiac beta-adrenergic receptors.
Treatment of rats with indomethacin, 1.5 mg/kg per day, for one week, significantly reduced the number of beta-adrenoceptors in the heart without altering their affinity for the specific beta-adrenergic ligand. In indomethacin-treated rats there was a reduction in the cardiac response to epinephrine in vivo as indicated by a shift to the right of the epinephrine dose-heart rate response curve. These results support a possible interference by indomethacin in beta-adrenoceptor-mediated effects.
D000818:Animals; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine; D007213:Indomethacin; D004837:Epinephrine