Digoxin in the elderly and in renal failure. Contribution of erythrocyte 86-rubidium uptake tests.
Na+,K+-ATPase activity was assessed indirectly in three groups of subjects of differing age, and in a group of patients with renal failure, by measuring the 86-rubidium uptake in the patients' own erythrocytes. The inhibiting action of digoxin on this activity was also measured in vitro. Erythrocyte 86Rb uptake was found to be lower in the elderly as was the calculated volume of distribution of digoxin. Sensitivity to the inhibiting action of digoxin increased with age. In the renal failure group 86Rb uptake was diminished and the sensitivity to digoxin was variable. This suggested that Na+,K+-ATPase activity could be one determinant of the volume of distribution of digoxin and that quantitative and qualitative changes of this enzyme could explain features of the pharmacokinetics of digoxin in renal failure and in old age.
D000328:Adult; D000367:Age Factors; D000368:Aged; D004077:Digoxin / Q000378:metabolism / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology / Q000378:metabolism*; D008875:Middle Aged; D011868:Radioisotopes; D012413:Rubidium; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D011868:Radioisotopes; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase; D012413:Rubidium