[Epidermodysplasia verruciformis (2 cases). Immunological study (author's transl)].
Flat wart-like lesions of two patients with epidermodysplasia verruciformis (EDV) were associated with pink, tan or depigmented pityriasis-like macules. There was no familial history nor mental retardation. Human papilloma virus (HPV) type 5 was demonstrated in the two patients and was responsible for the pityriasis-like lesions. Malignancies seem to be closely related to HPV-5 infection since bowenoid transformation occurred in the 2 patients. Immunological studies showed an increase of serum IgE in both patients and an important decrease of IgM in one of them. Most of delayed hypersensitivity skin tests were negative. T-cell percentages (E rosettes) were decreased in one patient, normal for the other one. The mitogenic response to PHA and ConA was markedly depressed in the two patients but returned to normal values in one of them after 3 months of aromatic retinoid (Ro 10-9359) treatment. Beside the viral type, the defect of cell mediated immunity could play an important role in the disease and in the malignant conversion of the lesions. A long-term preventive treatment by retinoic acid derivatives could be of interest for patients with HPV type 5 EDV.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D027383:Papillomaviridae / Q000302:isolation & purification; D011230:Precancerous Conditions / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology
Epidermodysplasie verruciforme (2 observations). Etude immunologique.