Alteration in adenylate cyclase response to aminergic stimulation following neonatal x-irradiation.
X-irradiation of the rat neonatal hippocampus produces severe alterations in the architectonic features of the mature hippocampus. The most prominent alterations is a marked depletion of the granule cells of the dentate gyrus, with a subsequent realignment of CA 4 cells. The present data also show that norepinephrine (NE), dopamine and histamine stimulation of adenylate cyclase activity is severely attenuated in the hippocampi of irradiated animals. This failure suggests that the NE fibers of irradiated subjects, although normal in content of NE, are not functional in some of their NE-effector actions.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000320:Adrenergic Fibers / Q000528:radiation effects; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006624:Hippocampus / Q000201:enzymology / Q000528:radiation effects*; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000528:radiation effects; D009638:Norepinephrine / Q000528:radiation effects*; D051381:Rats
D006632:Histamine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D004298:Dopamine; D009638:Norepinephrine