Modulation of ACTH-induced grooming by [Des-Tyr1]-gamma-endorphin and haloperidol.
Intraventricular administration of ACTH1-24 into the rat induced excessive grooming behavior. This response could be blocked by local administration of of neuroleptics into either the nucleus accumbens or the neostriatum. Local administration of [Des-Tyr1]-gamma-endorphine (LPH62-77) but not alpha-endorphin (LPH61-76) in either the nucleus accumbens or the neostriatum mimicked the effect of the neuroleptics. A second intraventricular injection of ACTH1-24 4 h after the first did not cause excessive grooming suggesting the development of acute tolerance. Both haloperidol and DT-gamma-E reduced the development of acute tolerance to ACTH-induced grooming. It is suggested the DT-gamma-E modulates the dopaminergic activity underlying the display of ACTH-induced excessive grooming.
D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D004874:Ergonovine / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects
D004723:Endorphins; D010446:Peptide Fragments; D011954:Receptors, Dopamine; C018903:gamma-endorphin, des-Tyr(1)-; D000324:Adrenocorticotropic Hormone; D006220:Haloperidol; D004874:Ergonovine