title: [Allergic contact eczema caused by isothiazolin-3-one derivatives].
abstract: Observations concerning contact dermatitis to derivatives of isothiazolin-3-one are reported. A systematic review of the literature of previously published cases is reported. A verified contact dermatitis to benzisothiazolin-3-one of a laborer in a rubber factory is discussed. Another case of occupational dermatitis concerns an allergy to a commercial product, containing 2-n-octyl-4-isothiazolin-3-one as a preservative and utilized by shoe factory workers. Additionally, cases of an allergy to cosmetic preparations, containing a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, are elaborated.
mesh_terms: D000328:Adult; D003876:Dermatitis, Atopic / Q000139:chemically induced*; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013844:Thiazoles / Q000009:adverse effects*
chemical_list: D013844:Thiazoles; C011506:2-methyl-4-isothiazolin-3-one; C035331:2-n-octyl-4-isothiazolin-3-one; C011421:5-chloro-2-methyl-4-isothiazolin-3-one; C015699:1,2-benzisothiazoline-3-one
vernacular_title: Allergisches Kontaktekzem durch Isothiazolin-3-on-Derivate.