Activation of complement by antibodies to the keratosulphate-like host antigen of Sendai virus.
Sendai virus is haemolytic against erythrocytes from different species. Pre-treatment of Sendai virus with antibody and complement (C) enhances the haemolytic activity of the virus. This property was used to examine the pathway by which C is activated by Sendai virus antigen-antibody complexes. Antibody against the keratosulphate-like host antigen was used in a monospecific antigen-antibody system. Evidence is presented that both the classical and the alternative pathway is activated; the alternative to a much lower extent.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral / Q000276:immunology*; D002645:Chickens / Q000097:blood; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D006461:Hemolysis; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D000956:Antigens, Viral