title: The mechanical and biochemical effects of pentoxifylline on the perfused rat heart.
abstract: Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010431:Pentoxifylline / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013805:Theobromine / Q000031:analogs & derivatives*
chemical_list: D012110:Reserpine; D000242:Cyclic AMP; D011494:Protein Kinases; D006152:Cyclic GMP; D013805:Theobromine; D010431:Pentoxifylline