[Megalocytic anemia of alcoholics and folic acid (author's transl)].
Megalocytic anemia of alcoholics is due to the deficiency of folic acid: the proof is the serum hypofolemia. The mechanism is complex and due to : a dietary deficiency; a malabsorption; an insufficiency of conversion of polyglutamate to monoglutamate; a liver deficiency; a specific effect of alcohol on the folate absorption. Alcohol has a toxic effect on the marrow and inhibits the folic acid.
D000328:Adult; D000437:Alcoholism / Q000150:complications*; D000748:Anemia, Macrocytic / Q000209:etiology*; D000749:Anemia, Megaloblastic / Q000209:etiology*; D001853:Bone Marrow / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005492:Folic Acid / Q000378:metabolism*; D005494:Folic Acid Deficiency / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000431:Ethanol; D005492:Folic Acid
L'anémie mégalocytaire des alcooliques et le rôle de l'acide folique.