[Characteristics of 3H-dihydroalprenolol binding to beta-receptors in the fat cells of rats and spontaneous genetic hypertension and in hypertensive disease].
The binding of 3H-dihydroalprenolol, a beta-antagonist, with the fat cell plasma membrane was studied in spontaneously hypertensive rats and in patients with essential hypertension. It was found that, as compared to control rats, hypertensive animals had an increased maximum number of 3H-DHA binding sites in the membranes and diminished affinity of beta-adrenoreceptors. It is suggested that these differences may play an essential role in the latered sensitivity to adrenalin in hypertensive rats. Removal of the adrenal, i. e. deprivation of the stabilizing corticosteroid effect, leads to marked changes in the state of the beta-adrenoreceptors in hypertensive animals. Thus, the maximum number of binding sites reduces in hypertensive rats but remains unaltered in the controls; following adrenalectomy the affinity of beta-adrenoreceptors increases in rats with hypertension, but in normal rats, on the contrary, does not change or rather has a tendency to decrease.
D000273:Adipose Tissue / Q000378:metabolism*; D000315:Adrenalectomy; D000526:Alprenolol / Q000031:analogs & derivatives*; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009852:Omentum / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D000526:Alprenolol
Osobennosti sviazyvaniia 3H-digidroalprenolola s beta-retseptorami v zhirovykh kletkakh u krys so spontannoĭ geneticheskoĭ gipertenzieĭ i pri gipertonicheskoĭ bolezni.