Effects of desipramine and yohimbine on alpha 2- and beta-adrenoreceptor sensitivity.
The effects of yohimbine on desipramine-induced adrenoreceptor alterations were examined in murine limbic forebrain areas. Treatment with both drugs in combination resulted in a significant decrease in [3H]dihydroalprenolol binding, which was not manifest after treatment with either drug alone. Moreover, co-administration of yohimbine was found to accelerate the time course and increase the magnitude of desipramine-induced increases in [3H]clonidine binding. The possible physiologic significance of these findings is discussed along with their pharmacologic implications.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003000:Clonidine / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology*; D004082:Dihydroalprenolol / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013997:Time Factors; D015016:Yohimbine / Q000494:pharmacology*
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D015016:Yohimbine; D004082:Dihydroalprenolol; D003000:Clonidine; D003891:Desipramine; D009638:Norepinephrine