title: CO2-sensitivity of stretch receptors in the marsupial lung.
abstract: Discharge activity in single fibres of the vagus of the brush tailed possum was examined for evidence of pulmonary CO2 receptors by artificially ventilating the lungs with gas mixtures which preserved, abolished or reversed the normal tidal oscillation in FCO2. No specific CO2 receptors were observed. A quantitative study of the CO2 sensitivity of thirteen pulmonary stretch receptors was carried out after stabilizing FACO2 at high (6.4-7.8%), low (1.4-2.5%) as well as intermediate values. In addition receptor responses to a series of sustained augmenting inflations were examined at different intrapulmonary CO2 concentrations. All thirteen receptors showed CO2 sensitivity, their frequency of discharge being reduced by hypercapnia and increased by hypocapnia. Five were low threshold receptors which discharged throughout the ventilatory cycle while the remaining eight were only phasically active. High threshold receptors were more sensitive to FACO2 changes than were low threshold units. The results from the series of augmenting inflations suggest that it is the receptor's threshold, but not its sensitivity, to tracheal pressure that is modulated by the co2 signal.
mesh_terms: D000200:Action Potentials; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008168:Lung / Q000502:physiology; D008465:Mechanoreceptors / Q000502:physiology*; D009893:Opossums / Q000502:physiology*; D011661:Pulmonary Stretch Receptors / Q000502:physiology*; D009435:Synaptic Transmission; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide