PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.
Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell-cell communication) in a manner similar to other known tumor promoters. Results suggest that PBB could act, epigenetically, as a teratogen and a carcinogenic promoter.
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002273:Carcinogens; D002450:Cell Communication / Q000187:drug effects*; D002460:Cell Line; D003043:Cocarcinogenesis; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007365:Intercellular Junctions / Q000187:drug effects; D008168:Lung; D011075:Polybrominated Biphenyls / Q000494:pharmacology*; D013866:Thioguanine
D001713:Biphenyl Compounds; D002273:Carcinogens; D011075:Polybrominated Biphenyls; D013866:Thioguanine