title: Local antibody response in avian infectious bronchitis: virus-neutralizing antibody in tracheobronchial secretions.
abstract: Specific-pathogen-free chickens were tested for local antibody response after respiratory exposure to live avian infectious bronchitis virus (IBV). Tracheobronchial secretions were obtained after intraocular-intratracheal vaccinations with Holland and Massachusetts 41 strains IBV. Low levels of immunoglobulin (Ig)A and IgG virus-neutralizing antibodies were detected in secretions after each of two vaccinations with a moderate dose (10(4) EID50), neutralizing activity in secretions was found mainly in IgG antibody. Only challenge exposure to Holland IBV resulted in a marked secondary secretion antibody response.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001980:Bronchi / Q000378:metabolism*; D002645:Chickens / Q000276:immunology*; D003332:Coronaviridae / Q000276:immunology*; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D001351:Infectious bronchitis virus / Q000276:immunology*; D009500:Neutralization Tests; D013047:Specific Pathogen-Free Organisms; D014132:Trachea / Q000378:metabolism*; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G