Attempts to transform primate cells in vitro by herpes simplex virus.
Attempts were made to transform human cervical cells and nonhuman primate cells with herpes simplex virus (HSV). None of 129 cervical cell cultures obtained from 29 patients and infected in vitro with various strains of HSV became transformed. Established cell lines of marmoset cells infected with HSV showed no characteristics of malignant transformation. Parallel cultures of rat embryo cells maintained under similar experimental conditions became malignant.
D000818:Animals; D002143:Callitrichinae; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002584:Cervix Uteri / Q000166:cytology / Q000382:microbiology; D005260:Female; D000882:Haplorhini; D006801:Humans; D009154:Mutation; D051381:Rats; D018139:Simplexvirus / Q000235:genetics / Q000528:radiation effects