Mouse-killing in rats induces a naloxone-blockable increase in nociceptive threshold.
Mouse-killing behaviour in rats increased the nociceptive threshold for paw licking, as measured in the hot-plate test. This effect was prevented by the opiate antagonist naloxone, which, on the other hand, had no influence on mouse-killing behavior per se. It is concluded that opioid mechanisms may be involved in changes of nociceptive threshold associated with aggressive behavior.
D000374:Aggression / Q000502:physiology*; D000698:Analgesia; D000818:Animals; D004056:Differential Threshold; D004723:Endorphins / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone