Experimental myringoplasty.
Artificial eardrums made from biodegradable poly(D,L-lactic acid), poly(glycolic acid) and poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50, and made from the microporous poly(tetrafluoroethylene) and bisphenol-A poly(carbonate) membranes were implanted into the ear and as a reference subcutaneously in rats. The implants were histologically examined for periods up to one year. From the biodegradable polymers studied the poly(beta-benzyl-L-aspartate-co-L-leucine) 50/50 evoked the least tissue reaction and the newly formed tympanic membranes are the best in terms of thickness and overall integrity. The microporous poly(tetrafluoroethylene) membrane can be considered as a valuable support for the formation of a reinforced tympanic membrane.
D000818:Animals; D001559:Benzhydryl Compounds; D001673:Biodegradation, Environmental; D055598:Chemical Phenomena; D002621:Chemistry; D007773:Lactates; D019344:Lactic Acid; D008567:Membranes, Artificial; D009225:Myringoplasty / Q000379:methods*; D010636:Phenols; D011091:Polyesters; D011100:Polyglycolic Acid; D011108:Polymers; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants; D051381:Rats; D000098826:Bisphenol A Compounds; D000098827:Polycarbonates
D001559:Benzhydryl Compounds; D007773:Lactates; D019344:Lactic Acid; D008567:Membranes, Artificial; D010636:Phenols; D011091:Polyesters; D011100:Polyglycolic Acid; D011108:Polymers; D011138:Polytetrafluoroethylene; C028237:bisphenol-A-polycarbonate; D000098826:Bisphenol A Compounds; D000098827:Polycarbonates; C028236:poly(beta-benzyl-L-aspartate-co-L-leucine); C033616:poly(lactide)