title: Prevalence and distribution of murine mammary tumor virus antigen detectable by immunocytochemistry in spontaneous breast tumors of wild mice.
abstract: Mouse mammary tumor virus (MuMTV) antigens were detected by immunoperoxidase cytochemistry in spontaneous breast tumors of wild mice from two widely separated areas of southern California. Eleven of 25 (44%) tumors from Lake Casitas (LC) mice and 4 of 5 tumors from Bouquet Canyon mice were positive. Included among the tumors lacking detectable MuMTV antigen were well-differentiated type A and type B carcinomas as well as tumors with an atypical pattern. In the antigen-positive tumors the distribution of staining was patchy and extremely variable in extent (less than 1-70% stained cells). The intensity and extent of staining were generally greater in breast tumors from hybrids of LC wild mice and C5LBL/10Sn or AKR inbred mice. A good correlation was found in the same tumors between immunoperoxidase staining, detection of MuMTV gp52 antigen by radioimmunoassay, and detection of type B particles by electron microscopy. All of the breast tumors in LC mice were positive for type C virus particles.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D000375:Aging; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis / Q000276:immunology*; D002140:California; D006651:Histocytochemistry; D007120:Immunochemistry; D007181:Inclusion Bodies, Viral; D008321:Mammary Glands, Animal; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology*; D051379:Mice; D008854:Microscopy, Electron; D009369:Neoplasms / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D011863:Radioimmunoassay; D012376:Rodent Diseases / Q000276:immunology* / Q000382:microbiology
chemical_list: D000956:Antigens, Viral