title: Rat kappa-chain allotypes. III. Serological and genetic analysis of RI-1b cross-reactivity in Australian Rattus.
abstract: The presence of rat kappa-chain allotype specificities (RI-1a and b) has been studied in 13 subspecies of the seven native Australian species of Rattus. RI-1a reactivity was not detected among these rats. On the other hand, extensive cross-reactivity was seen with RI-1b, some sera cross-reacting totally (R. leucopus cooktownensis), some not at all (R. colletti), and the remainder showing at least two distinct levels of partial cross-reactivity, confirming the existence of multiple specificities for RI-1b. Three subspecies show polymorphism with respect to RI-1b cross-reactivity (R. sordidus, R. colletti, and R. l. leucopus) and in one case (leucopus) breeding studies have indicated that there is allelic inheritance of this trait. The segregation of RI-1b reactivity has been studied in crosses and backcrosses made between species differing in their RI-1b reactivity, and the results are consistent with the existence of codominant alleles at a single locus. The fact that these species differ extensively in their karyotype opens the door to possible chromosomal localization of this and other genetic traits.
mesh_terms: D000818:Animals; D001315:Australia; D003429:Cross Reactions; D003433:Crosses, Genetic; D005260:Female; D007125:Immunogenetics; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008297:Male; D009115:Muridae / Q000235:genetics / Q000276:immunology*; D010375:Pedigree; D051381:Rats; D013045:Species Specificity
chemical_list: D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains