Postsynaptic transmission block can cause terminal sprouting of a motor nerve.
Sprouting of mouse soleus motor nerve terminals can be evoked by daily intramuscular injections of purified alpha-bungarotoxin. This finding supports the hypothesis that an important stimulus to terminal sprouting in partial denervation and presynaptic nerve blockade is a product of inactive muscle fibers.
D000818:Animals; D001905:Botulinum Toxins / Q000494:pharmacology; D002038:Bungarotoxins / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009045:Motor Endplate / Q000187:drug effects; D009046:Motor Neurons / Q000254:growth & development*; D009132:Muscles / Q000294:innervation; D009469:Neuromuscular Junction / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D001905:Botulinum Toxins