Stimulation of macromolecular synthesis by endotoxin-treated 3T6 fibroblasts.
The interaction of endotoxin with cultured fibroblasts resulted in a depression of cellular proliferation and an increased synthesis of macromolecules, namely collagenous and non-collagenous proteins. The collagen salt-soluble fraction was increased at the expense of the insoluble fraction, and both the salt-soluble fraction and collagen secreted into the medium was underhydroxylated.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis; D004731:Endotoxins / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D003012:Microbial Collagenase; D014176:Protein Biosynthesis
D004731:Endotoxins; D003094:Collagen; D003012:Microbial Collagenase