Dissociation of increases in cyclic GMP from relaxation of arterial smooth muscle.
Glyceryl trinitrate increased the cyclic GMP content of epinephrine-contracted aortic strips from glyceryl trinitrate-tolerant rats in a dose-dependent manner. Glyceryl trinitrate (.05 millimicron/ml) at a concentration that caused to relaxation of aortas from tolerant animals but a 42.4  3.7% relaxation of control aortas, elevated cyclic GMP levels in both groups approximately 3-fold. The results are not consistent with the hypothesis that cyclic GMP is involved in the relaxation of arterial smooth muscle.
D000818:Animals; D006152:Cyclic GMP / Q000032:analysis*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000032:analysis* / Q000187:drug effects; D005996:Nitroglycerin / Q000494:pharmacology; D051381:Rats
D005996:Nitroglycerin; D006152:Cyclic GMP