Marrow-dependent cells depleted by 89Sr mediate genetic resistance to herpes simplex virus type 1 infection in mice.
Adult mice resistant to infection with 10(6) plaque-forming units of a virulent strain of herpes simplex virus type 1 were treated with 89Sr to abrogate marrow-dependent cell functions. Treated mice were found to be much more susceptible to the herpes simplex virus type 1 infection than untreated mice. The virus persisted in the visceral tissues of 89Sr-treated mice for 3 or more days postinfection but not in those of untreated mice. The virus also spread to the spinal cords of treated but not untreated mice. A marrow-dependent cell appeared to mediate resistance to herpes simplex virus type 1 by controlling the infection early after inoculation and not allowing the infection spread to the central nervous system.
D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D006561:Herpes Simplex / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D007113:Immunity, Innate; D051379:Mice; D018139:Simplexvirus / Q000276:immunology / Q000302:isolation & purification; D013116:Spinal Cord / Q000276:immunology; D013326:Strontium Radioisotopes / Q000008:administration & dosage*
D000956:Antigens, Viral; D013326:Strontium Radioisotopes