title: Analysis of recombination in mammalian cells using SV40 genome segments having homologous overlapping termini.
abstract: Segments of SV40 DNA having homologous overlapping termini recombine to produce viable genomes in monkey cells. Frequencies of recombination on either side of a deletion marker are non-random; replication and palindromes do not appear to be essential. Since recombination involves host enzymes, a suitable system has been devised for analysing host cell recombination functions.
mesh_terms: D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D004279:DNA, Viral / Q000378:metabolism*; D005814:Genes, Viral; D011995:Recombination, Genetic; D013539:Simian virus 40 / Q000378:metabolism*; D014162:Transfection; D010948:Viral Plaque Assay
chemical_list: D004279:DNA, Viral