Dehydroepiandrosterone and 16 alpha-bromo-epiandrosterone: inhibitors of Epstein-Barr virus-induced transformation of human lymphocytes.
Dehydroepiandrosterone (DHEA), a major adrenal secretory product in men and women, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). Long-term treatment with this steroid has previously been found to suppress spontaneous breast cancer development in C3H mice. DHEA is now shown to inhibit Epstein-Barr virus (EBV)-induced morphologic transformation and stimulation of DNA synthesis in human lymphocytes. 16 alpha-Br-epiandrosterone, a DHEA analog that is about 60 times as potent as DHEA as an inhibitor of G6PDH, is much more effective as an inhibitor of EBV-induced transformation.
D000738:Androsterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004854:Herpesvirus 4, Human; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology; D051381:Rats; D013936:Thymidine / Q000378:metabolism
D008934:Mitogens; C032020:16-bromoepiandrosterone; D003687:Dehydroepiandrosterone; D004247:DNA; D000738:Androsterone; D013936:Thymidine