Effect of 1 alpha-hydroxyvitamin D3 on the glucose and calcium metabolism in genetic obese mice.
In summary, it is demonstrated, for the first time, that there is a marked reduction of bone mass in ob/ob mice and this was restored by the treatment with 1 alpha-OH-D3. The effect of the sterol was accompanied by the improvement of hyperglycemia, hyperinsulinemia, and fat tissue responsibility to hormones. Thus, it is of interest to study obesity in terms of calcium homeostasis.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D051379:Mice; D009765:Obesity / Q000235:genetics / Q000378:metabolism*
D001786:Blood Glucose; D006887:Hydroxycholecalciferols; D007328:Insulin; D000242:Cyclic AMP; D005947:Glucose; D002118:Calcium; C008088:alfacalcidol