title: Pathologic features of horses given avirulent equine arteritis virus intramuscularly.
abstract: Twenty horses that were seronegative for equine arteritis virus antibodies were inoculated IM with live equine arteritis virus vaccine. The inoculation did not cause clinical signs of disease. A mild, transient febrile reaction developed in 6 horses, 3 of which were in poor condition before inoculation. Six horses, 2 of which were in poor condition before inoculation, experienced mild lymphopenia. Necropsy revealed mild lesions in the lymph nodes of 6 horses (3 of which were in poor condition before inoculation). Maximum concentrations of virus were detected in the lymph nodes and were consistently present from postvaccination day 3 through 8. Lesser concentrations of virus were detected in the spleen of 5 horses, liver and kidney of 4, abdominal fluid of 3, pleural fluid of 2, and lungs and urine of 1, between postvaccination days 3 and 7. Virus was not detected in the brain, nasal tract, or serum of any of the horses.
mesh_terms: D000818:Animals; D007240:Equartevirus / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D005334:Fever / Q000209:etiology / Q000662:veterinary; D006734:Horse Diseases / Q000209:etiology* / Q000473:pathology; D006736:Horses; D007273:Injections, Intramuscular / Q000662:veterinary; D008198:Lymph Nodes / Q000473:pathology; D008231:Lymphopenia / Q000209:etiology / Q000662:veterinary*; D008297:Male; D009928:Organ Specificity; D012328:RNA Viruses / Q000276:immunology*; D014765:Viral Vaccines / Q000009:adverse effects*
chemical_list: D014765:Viral Vaccines