Effects of arachidonic acid on rat gastric acid secretion in response to different secretogogues; inhibition of these effects by indomethacin.
1 The effects of the prostaglandin precursor, arachidonic acid, and the non-steroidal anti-inflammatory drug, indomethacin, on gastric acid secretion were studied in the rat, in vivo and in vitro. Gastric mucosal blood flow was also measured in vivo. 2 Arachidonate produced significant inhibition of acid secretion stimulated by pentagastrin or histamine. It did not significantly affect dibutyryl cyclic adenosine 3',5'-monophosphate (db cyclic AMP)-induced acid secretion. 3 Inhibition of acid secretion by arachidonate was accompanied by a rise in the ratio of mucosal blood flow to acid secretion. 4 Indomethacin did not significantly alter histamine- or pentagastrin-induced acid secretion. 5 In the presence of indomethacin, the inhibitory effect of arachidonate was significantly reduced. 6 These results provide evidence that the rat gastric mucosa is capable of synthesizing, from exogenous precursor, products of cyclo-oxygenase which inhibit gastric acid secretion.
D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply; D006633:Histamine Antagonists; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats
D001095:Arachidonic Acids; D006633:Histamine Antagonists; D011453:Prostaglandins; D003994:Bucladesine; D010418:Pentagastrin; D007213:Indomethacin