title: Plasma cyclic 3',5'-guanosine monophosphate and cyclic 3',5'-adenosine monophosphate response to methacholine in man.
abstract: Cholinergic agents are known to induce increases in tissue and plasma levels of cyclic GMP in experimental animals. We observed that i.m. injection of methacholine, a cholinergic agent, caused significant increases in plasma cyclic GMP and cyclic AMP in man.
mesh_terms: D000293:Adolescent; D000328:Adult; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male; D008688:Methacholine Compounds / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D008688:Methacholine Compounds; D000242:Cyclic AMP; D006152:Cyclic GMP