A non-virion surface antigen on Moloney sarcoma virus-transformed non-producer and producer cells.
Sera from STU mice bearing sarcomas induced by cells producing the Moloney sarcoma-helper-virus (M-MSV/MLV) complex were cytotoxic for these cells as well as for M-MSV non-producer and M-MLV producer cells. Analysis by polyacrylamide gel electrophoresis of 125I-labelled surface antigens immunoprecipitated with such sera revealed the virus envelope glycoprotein gp71 on the producer cells and an additional antigen of mol. wt 55 K on the M-MSV-transformed producer and non-producer cells. This antigen was not found on non-transformed M-MLV-producing cells and was neither related serologically to structural polypeptides of murine C-type viruses nor to components of embryonal STU mouse fibroblasts and foetal bovine serum.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003673:Defective Viruses / Q000276:immunology; D006378:Helper Viruses / Q000276:immunology; D051379:Mice; D008979:Moloney murine leukemia virus / Q000276:immunology*; D012509:Sarcoma / Q000276:immunology; D009053:Sarcoma Viruses, Murine / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000276:immunology; D014776:Virus Cultivation
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D000956:Antigens, Viral