Effects of hematoporphyrin (HPD) and a chemiluminescence system on the growth of transplanted tumors in C3H/HeJ mice.
Photoradiation therapy is emerging as a promising technique for combating cancer. Fundamentally, this approach consists of two steps: hematoporphyrin derivative (HPD) is used to selectively sensitize cancer cells to visible light; after an appropriate time interval, light is introduced into the tumor via a laser-fiber optic system to trigger the cytotoxic action of HPD. The present investigation was initiated to determine the therapeutic potential of HPD in combination with a chemiluminescent activator in treating mice which had been transplanted with tumors.
D000818:Animals; D005260:Female; D017324:Hematoporphyrin Derivative; D006415:Hematoporphyrins / Q000627:therapeutic use*; D008163:Luminescent Measurements; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D009279:Naphthacenes / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010778:Photochemotherapy / Q000379:methods*
D006415:Hematoporphyrins; D009279:Naphthacenes; C045049:rubrene; D017324:Hematoporphyrin Derivative; D010072:Oxamic Acid; C008728:oxamide