The effect of nisin on murein synthesis.
Nisin inhibits murein synthesis with concomitant accumulation of undecaprenyl-pyrophospho-MurHAc(pentapeptide) (lipid intermediate I). This inhibition is caused by the formation of a complex between the antibiotic and lipid intermediate I. Undecaprenyl-pyrophospho-MurNAc(pentapeptide)-GlcNAc (lipid intermediate II) also forms a complex with nisin. However, when murein synthesis is inhibited by nisin, this latter complex is not formed since lipid intermediate II is not longer synthesized.
D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000494:pharmacology; D009561:Nisin / Q000494:pharmacology*; D010457:Peptidoglycan / Q000096:biosynthesis*; D010770:Phosphotransferases / Q000378:metabolism; D014537:Uridine Diphosphate N-Acetylglucosamine / Q000378:metabolism; D014538:Uridine Diphosphate N-Acetylmuramic Acid / Q000378:metabolism
D010457:Peptidoglycan; D014538:Uridine Diphosphate N-Acetylmuramic Acid; D009561:Nisin; D014537:Uridine Diphosphate N-Acetylglucosamine; D010770:Phosphotransferases; D008274:Magnesium