Cellular site of opiate dependence.
Experiments on whole animals, guinea pig isolated ileum, individual neurones in situ and cultured neuroblastoma--glioma hybrid cells indicate that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones). The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase.
D000200:Action Potentials; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D004361:Drug Tolerance; D006168:Guinea Pigs; D006801:Humans; D006822:Hybrid Cells / Q000187:drug effects; D007082:Ileum / Q000294:innervation; D066298:In Vitro Techniques; D009197:Myenteric Plexus / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D009293:Opioid-Related Disorders; D011957:Receptors, Opioid / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
D011957:Receptors, Opioid; D009270:Naloxone; D000242:Cyclic AMP