Transplacental infection with adeno-associated virus type 1 in mice.
Adeno-associated type 1 parvovirus (AAV) was detected in the kidneys and lungs of fetuses and newborns, when pregnant mice were injected subcutaneously with AAV type 1 and murine adenovirus as a helper virus. These findings clearly indicate that transplacental infection with AAV in rodents has been achieved.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D000229:Dependovirus / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D005260:Female; D007668:Kidney / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D051379:Mice; D010920:Placenta / Q000382:microbiology*; D011247:Pregnancy; D014777:Virus Diseases / Q000151:congenital*
D000956:Antigens, Viral