Effects of two histamine H2-receptor blocking drugs on basal levels of gonadotrophins, prolactin, testosterone and oestradiol-17 beta during treatment of duodenal ulcer in male patients.
In a study of 51 male patients with duodenal ulcer, treatment with cimetidine was accompanied by an increase in basal levels of serum testosterone. Treatment with ranitidine, a new histamine H2-receptor antagonist, produced no such effect. It is concluded that cimetidine had antiandrogenic activity in man which is separate from the histamine H2-receptor blocking activity.
D000328:Adult; D002927:Cimetidine / Q000009:adverse effects* / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000097:blood / Q000188:drug therapy*; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D005663:Furans / Q000009:adverse effects* / Q000627:therapeutic use; D006146:Guanidines / Q000009:adverse effects*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D011899:Ranitidine; D011944:Receptors, Androgen / Q000187:drug effects*; D011987:Receptors, Steroid / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D005663:Furans; D006146:Guanidines; D011944:Receptors, Androgen; D011987:Receptors, Steroid; D013739:Testosterone; D004958:Estradiol; D002927:Cimetidine; D011899:Ranitidine; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone