[Effect of 5'-deoxy-5'-S-isobutyladenosine on hematopoietic stem cells].
Unlike known cytostatics, 5'-deoxy-5'-S-isobutyladenosine (SIBA) does not inhibit proliferative activity of hemopoietic stem cells of intact bone marrow. On the contrary, it raises CFUs number of 15-28% in vitro and in vivo. SIBA inhibits by 40% the 3',5'-cAMP-induced increase in CFUs proliferation.
D000818:Animals; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D000242:Cyclic AMP / Q000008:administration & dosage; D003839:Deoxyadenosines / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006824:Hybridization, Genetic; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013872:Thionucleosides / Q000008:administration & dosage / Q000494:pharmacology*
D003839:Deoxyadenosines; D013872:Thionucleosides; C013919:5'-deoxy-5'-S-isobutylthioadenosine; D000242:Cyclic AMP
Vliianie 5'-dezoksi-5'-S-izobutiladenozina na stvolovye krovetvornye kletki.