title: Establishment of rotavirus persistent infection in cell culture. Brief report.
abstract: Inoculation of the rabbit kidney cell line (RK13) with simian rotavirus SA11 resulted in persistently infected (carrier) cultures. A small percentage of these cells produced infectious virus (> 25 passages) and trypsin treatment enhanced virus production.
mesh_terms: D000818:Animals; D002460:Cell Line; D007668:Kidney; D011817:Rabbits; D012087:Reoviridae / Q000254:growth & development*; D012401:Rotavirus / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D013696:Temperature; D014357:Trypsin / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D014357:Trypsin