Induction of Epstein-Barr virus early antigen, virus capsid antigen and virus DNA synthesis by mitomycin C.
The effect of mitomycin C was tested on Epstein-Barr virus (EBV) antigen and virus DNA synthesis in producer and non-producer cell lines. We found that producer, but not non-producer cell lines, are inducible for early antigen and virus capsid antigen synthesis. Although host DNA synthesis is effectively inhibited by over 99% in the presence of mitomycin C, virus DNA synthesis in the producer lines is unaffected and induced in parallel with the virus antigens.
D000956:Antigens, Viral; D002213:Capsid / Q000096:biosynthesis*; D002460:Cell Line; D004279:DNA, Viral / Q000096:biosynthesis*; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D006801:Humans; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis*
D000956:Antigens, Viral; D004279:DNA, Viral; D008937:Mitomycins; D014764:Viral Proteins; D016685:Mitomycin