Induction of neoplasms by subgroup E recombinants of exogenous and endogenous avian retroviruses (Rous-associated virus type 60).
Chickens susceptible to infection with subgroup E viruses were inoculated with four independent isolates of Rous-associated virus type 60 (RAV-60) that are subgroup e recombinants of endogenous and exogenous virus. Neoplasms developed in each inoculated group. Therefore, nontransforming viruses of subgroup E can induce lymphoid leukosis at a moderate rate compared with RAV-0, a subgroup E endogenous virus, suggesting that oncogenicity is not a viral envelope (env)-related characteristic. Since the common (c) regions of the RAV-60s examined were of exogenous origin, we suggest that the c region rather than env is important for a high rate of induction of lymphoid leukosis and related neoplasms.
D000818:Animals; D001353:Avian Leukosis / Q000209:etiology; D001354:Avian Leukosis Virus / Q000235:genetics / Q000472:pathogenicity*; D001358:Avian Sarcoma Viruses / Q000235:genetics / Q000472:pathogenicity*; D002642:Chick Embryo; D002645:Chickens; D009374:Neoplasms, Experimental / Q000209:etiology