[On the biological action of transition metal complexes. 1. The antiviral activity of palladium aminopyridin-complexes (author's transl)].
Some aminopyridine complexes of palladium and PdCl2 showed an antiviral in vitro activity against enveloped DNA and RNA viruses such as vaccinia virus, pseudorabies virus, NDV and FPV. In contrast, naked RNA virus as mengovirus was not affected. The compounds were compatible for chicken embryo as well as FL cells in concentrations of 100-250 microM. The therapeutical index calculated from the maximally tolerated dose and the concentration causing a 50 per cent plaque reduction was determined with more than 45 for vaccinia virus, for example.
D000631:Aminopyridines / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004267:DNA Viruses / Q000187:drug effects*; D011558:Herpesvirus 1, Suid / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects; D008574:Mengovirus / Q000187:drug effects; D009522:Newcastle disease virus / Q000187:drug effects; D010165:Palladium / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects*; D014616:Vaccinia virus / Q000187:drug effects; D010948:Viral Plaque Assay
D000631:Aminopyridines; D000998:Antiviral Agents; D010165:Palladium
Uber biologische Wirkungen von Koordinationsverbindungen der Ubergangsmetalle. 1. Antivirale Wirkung von 2-Aminopyridinkomplexen des Palladiums.