Variable susceptibility of mice to group B coxsackievirus infections.
Laboratory strains of group B coxsackievirus serotypes 1 to 6 were inoculated intraperitoneally into newborn mice of differing genetic backgrouns. Of the four genetic strains investigated, C3H mice appeared to be resistant to all six serotypes, whereas BALB/c mice were most susceptible. Swiss mice and a random-bred Swiss strain (COH) were intermediate in susceptibility. The findings underscore the fact that clinical isolation attempts and experimental studies involving group B coxsackieviruses must take into account both the virus strain used and the genetic background of the host. For clinical isolation of these viruses, the BALB/c mouse may be the most suitable of th strains tested.
D000818:Animals; D003384:Coxsackievirus Infections / Q000276:immunology / Q000382:microbiology*; D004660:Encephalitis / Q000382:microbiology; D029822:Enterovirus B, Human / Q000145:classification / Q000276:immunology; D006505:Hepatitis / Q000382:microbiology; D051379:Mice / Q000235:genetics / Q000276:immunology*; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D009205:Myocarditis / Q000382:microbiology; D010195:Pancreatitis / Q000382:microbiology; D012703:Serotyping