Acute systemic anaphylaxis in adult domestic fowl: evidence for the protective role of H2-histaminergic and beta 2-adrenergic receptors.
Pentobarbital-anesthetized and spontaneously breathing, bovine albumin (BA)-sensitized adult domestic fowl showed acute systemic anaphylaxis to IV injection of antigen (BA), which was characterized by arterial hypotension, central venous hypertension, and bradycardia. Large doses of pyrilamine maleate (/1-receptor antagonist) partially inhibited acute systemic anaphylaxis. On the other hand, metiamide (a specific H2-antagonist) and propranolol (beta-adrenergic antagonist) markedly enhanced the anaphylactic response. Terbutaline (beta 2-agonist), dimaprit (a highly selective H2-agonist), and compound FPL 55712 (a slow-reacting substance of anaphylaxis receptor antagonist) either significantly inhibited or reversed the anaphylactic response. Cimetidine (a newer H2-antagonist) enhanced only central venous pressor response to BA. This investigation appears to suggest a minor role of histamine and a major role of slow-reacting substance of anaphylaxis as chemical mediatiors of anaphylaxis. A protective role of beta 2-adrenergic and H2-histaminergic receptors seem to operate in immediate hypersensitivity reactions in adult domestic fowl.
D000707:Anaphylaxis / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002339:Carotid Arteries / Q000187:drug effects / Q000503:physiopathology; D002645:Chickens; D002867:Chromones / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D017259:Dimaprit; D004987:Ethers / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008785:Metiamide / Q000494:pharmacology; D011201:Poultry Diseases / Q000503:physiopathology*; D011433:Propranolol / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D011968:Receptors, Histamine / Q000502:physiology*; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology*; D013726:Terbutaline / Q000494:pharmacology; D013890:Thiourea / Q000494:pharmacology
D002867:Chromones; D004987:Ethers; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D008785:Metiamide; D002927:Cimetidine; C006312:FPL 55712; D011433:Propranolol; D013890:Thiourea; D011738:Pyrilamine; D013726:Terbutaline; D017259:Dimaprit