Glioblastoma multiforme occurring 13 years after treatment of a medulloblastoma.
Although medulloblastoma is said to be capable of astrocytic differentiation, the development of an astrocytic neoplasm in association with a medulloblastoma is extremely rare. We report the light and electron microscopic features of a supratentorial glioblastoma that occurred 13 years after radiation therapy for a cerebellar medulloblastoma. The diverse ultrastructural features of the glioblastoma may reflect the multipotentiality of the cells in medulloblastoma. An alternate interpretation is that the glioblastoma represents a radiation-induced neoplasm after therapy for a medulloblastoma.
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000628:therapy; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000209:etiology / Q000532:radiotherapy; D002648:Child; D002675:Child, Preschool; D005909:Glioblastoma / Q000209:etiology* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D008854:Microscopy, Electron; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009778:Occipital Lobe / Q000601:surgery