Enhanced macrophage and natural killer cell antitumor activity by various molecular weight maleic anhydride divinyl ethers.
A series of Maleic anhydride divinyl ether (MVE) polyanions, synthesized with molecular weight ranging from 12500 to 52600, were found capable of enhancing macrophage tumoricidal activity of MBL-2 leukemia cells. These agents also augmented Natural Killer cell activity against the YAC lymphoma and M109 adenocarcinoma cell lines.
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000628:therapy; D000818:Animals; D002460:Cell Line; D007694:Killer Cells, Natural / Q000187:drug effects*; D007942:Leukemia, Experimental / Q000628:therapy; D008175:Lung Neoplasms / Q000628:therapy; D008223:Lymphoma / Q000628:therapy; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D008979:Moloney murine leukemia virus; D009374:Neoplasms, Experimental / Q000628:therapy*; D011108:Polymers / Q000494:pharmacology*; D011713:Pyran Copolymer / Q000494:pharmacology*
D011108:Polymers; D011713:Pyran Copolymer