title: Some problems in modern anti-ulcer drug evaluation: a comparison of four gastric acid suppressors.
abstract: Some of the problems involved in the treatment and evaluation of drug therapy in peptic ulceration are discussed. The results of four multi-centre, double-blind, placebo-controlled clinical trials in 520 patients are reviewed. It has been shown that the potent suppressors of gastric acid secretion, histamine H2-blockers ranitidine and cimetidine, and 16,16-dimethyl prostaglandin E2, significantly accelerated the healing of peptic ulcers but that trithiozine had no beneficial effect.
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003864:Depression, Chemical; D004341:Drug Evaluation; D005663:Furans / Q000627:therapeutic use; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D009025:Morpholines / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use; D011899:Ranitidine
chemical_list: D000897:Anti-Ulcer Agents; D005663:Furans; D009025:Morpholines; D011459:Prostaglandins E, Synthetic; C017244:16,16-dimethylprostaglandin E; D002927:Cimetidine; D011899:Ranitidine; C012595:trithiozine