[A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies (author's transl)].
The effects of procyanidol oligomers on capillary resistance disorders in hypertensive and diabetic patients were studied. The drug was administered in a daily dose of 150 mg. Concordant results were obtained in two investigations as follows: during an open trial in 28 patients, capillary resistance (measured by the technique of Lavollay) rose from 15,4 +/- 1,8 cm Hg to 18,1 +/- 3,2 cm Hg (p less than 0,0005); and during a double blind trial versus placebo (25 patients) capillary resistance rose from 14,6 +/- 0,98 cm Hg to 18 +/- 3,35 cm Hg (p less than 0,005) in the treated group, while no significant variation was observed in the placebo group (15,5 +/- 1,30 cm Hg versus 14,7 +/- 1,3 cm Hg initially). The drug was well tolerated.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001578:Benzopyrans / Q000627:therapeutic use*; D044946:Biflavonoids; D002200:Capillary Resistance / Q000187:drug effects*; D002392:Catechin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004487:Edema / Q000188:drug therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D044945:Proanthocyanidins
D001578:Benzopyrans; D044946:Biflavonoids; D044945:Proanthocyanidins; C017674:procyanidin; D002392:Catechin
Etude des effets des oligomères du procyanidol sur la résistance capillaire dans l'hypertension artérielle et certaines néphropathies.