Cyclic AMP and gastric acid secretion in the dog.
Canine gastric secretions were collected for acid and cyclic AMP assay at zero, 15, 30, 45 and 60 minutes during intravenous infusion of zero, 2.5 and 5.0 micrograms/kg/hr of pentagastrin. A resulting brisk acid response was not accompanied by an elevation of cyclic AMP content. It is thereby suggested that cyclic AMP may not be an obligatory intermediary for gastric acid secretion.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism / Q000502:physiology*; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism*; D010418:Pentagastrin / Q000494:pharmacology
D000242:Cyclic AMP; D010418:Pentagastrin