Carcinogenicity of 2-amino-4-(5-nitro-2-furyl) thiazole in rats by oral and subcutaneous administration.
Female Fischer rats were divided into two groups and fed either basal diet or basal diet containing 0.166% 2-amino-4-(5-nitro-2-furyl) thiazole for 52 weeks followed by basal diet for an additional 16 weeks. Our of the 24 rats fed 2-amino-4-(5-nitro-2-furyl) thiazole, 23 had forestomach tumors, four had fibroadenomas and two had adenocarcinomas in the mammary glands, two had renal pelvic carcinomas, five had papillomas and six had carcinomas in the bladder, and two had cutaneous tumors. None of the 10 rats fed basal diet developed tumors. In another study, two-week-old Fischer rats of both sexes were injected s.c. once a week for the first eight weeks with 2-amino-4-(5-nitro-2-furyl) thiazole at a dose of 10 mg/kg and then 1.4 mg/rat for an additional 46 weeks. The control rats were injected with solvent (dimethyl sulfoxide: water, 1:1) only. The experiment was terminated at the end of 58 weeks. Malignant fibrous histiocytomas were found in five out of eight male rats and four out of 11 female rats, and an angiosarcoma was found in one out of eight male rats injected with 2-amino-4-(5-nitro-2-furyl) thiazole. None of the control rats developed tumors.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D004032:Diet; D005200:FANFT / Q000031:analogs & derivatives / Q000633:toxicity*; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000139:chemically induced; D007279:Injections, Subcutaneous; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012878:Skin Neoplasms / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced; D013844:Thiazoles / Q000633:toxicity*; D014571:Urologic Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D013844:Thiazoles; C024885:ANFT; D005200:FANFT