Presynaptic receptors and modulation of the release of noradrenaline, dopamine and GABA.
A review of the role of presynaptic receptors in the modulation of neurotransmitter release indicates two types of presynaptic receptors. By means of presynaptic inhibitory autoreceptors a neurotransmitter can regulate its own release. In addition, presynaptic receptors are acted upon by other endogenous compounds, either transmitters released from adjacent nerve terminals, blood-borne compounds or locally-formed substances, involved in trans-synaptic feed-back. Both types of presynaptic receptors may be involved in the physiological control of transmitter release and are the target of drug action, either as agonists or as antagonists.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004298:Dopamine / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D011945:Receptors, Angiotensin / Q000502:physiology; D011976:Receptors, Muscarinic / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011957:Receptors, Opioid / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
D011458:Prostaglandins E; D011943:Receptors, Adrenergic, beta; D011945:Receptors, Angiotensin; D011976:Receptors, Muscarinic; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid; D005680:gamma-Aminobutyric Acid; D000241:Adenosine; D004298:Dopamine; D009638:Norepinephrine