title: [Effect of dehydrocorrine-cobalt complex on mitochondria].
abstract: The effects of the decamethyloctadehydrocorrine-cobalt complex (Co-C) on respiration and the ATP-synthetase activity of rat liver mitochondria were investigated. The Co-C complex was found to be an effective shunt of the respiratory chain. It accepts electrons from ubiquinone and donates them directly to O2. The Co-C complex inhibits the ATPase and ATP-synthetase activities of mitochondria.
mesh_terms: D025181:ATP Synthetase Complexes; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D004579:Electron Transport / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors; D010101:Oxygen Consumption / Q000187:drug effects*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors; D051381:Rats; D014805:Vitamin B 12 / Q000494:pharmacology*
chemical_list: D009097:Multienzyme Complexes; D010770:Phosphotransferases; D025181:ATP Synthetase Complexes; D000251:Adenosine Triphosphatases; D014805:Vitamin B 12
vernacular_title: Vliianie degidrokorrinovogo kompleksa kobal'ta na mitokhondrii.