Malignant fibrous histiocytoma of the temporal bone with intracranial extension.
An 18-year-old male presented with a right temporal bone tumour; histology revealed malignant fibrous histiocytoma. Following surgical excision and radiation the tumour recurred. The patient was treated with Vindesine (desacetyl vinblastine amide sulphate) with marked response. Malignant fibrous histiocytomas of the temporal bone are extremely rare; this report suggests that the occasional dramatic response may be obtained by combined modality treatment.
D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D012888:Skull Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D013701:Temporal Bone / Q000473:pathology*; D014747:Vinblastine / Q000031:analogs & derivatives / Q000627:therapeutic use; D014751:Vindesine
D014747:Vinblastine; D014751:Vindesine