Expression of bovine leukemia virus genome is blocked by a nonimmunoglobulin protein in plasma from infected cattle.
Plasma of cattle infected with bovine leukemia virus contains a soluble factor that blocks the expression of the viral genome in cultured lymphocytes. The blocking factor is not present in plasma of bovine leukemia virus-free cattle or of cattle infected with common bovine viruses. Blocking of bovine leukemia virus expression by the plasma factor is reversible, and seems to be mediated by a nonimmunoglobulin protein molecule.
D000818:Animals; D001798:Blood Proteins / Q000494:pharmacology; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000187:drug effects; D007938:Leukemia / Q000097:blood*; D001909:Leukemia Virus, Bovine / Q000235:genetics*; D008214:Lymphocytes / Q000382:microbiology; D012190:Retroviridae / Q000235:genetics*; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics; D014779:Virus Replication
D001798:Blood Proteins; D014764:Viral Proteins