[Use of luminescent analysis for studying the characteristics of the virus-inhibiting action of polyene antibiotics].
The inhibitory effect of flavopentin was shown on the models of infectious and oncogenic viruses. Flavopentin is a polyenic antibiotic belonging to pentaenes. The characteristic features of the polyene interaction with the plasma membrane of the host cell were defined with the use of the luminescence analysis, when the antibiotic was applied with the therapeutic or prophylactic purposes in experimental influenzal infection.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology*; D000998:Antiviral Agents / Q000032:analysis / Q000494:pharmacology*; D001358:Avian Sarcoma Viruses / Q000187:drug effects; D002642:Chick Embryo; D009980:Influenza A virus / Q000187:drug effects; D011090:Polyenes / Q000032:analysis / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D014616:Vaccinia virus / Q000187:drug effects; D014776:Virus Cultivation
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D011090:Polyenes; C031806:flavopentin
Ispol'zovanie liuminestsentnogo analiza dlia izucheniia osobennosteĭ virusingibiruiushchego deĭstviia polienovykh antibiotikov.