Disruption of conditioned taste aversion by the combined effects of LiCl and ECS.
Rats were taught a conditioned taste aversion by allowing them to drink sucrose (CS) for 5 min and 30 min later poisoning them with LiCl (UCS). Experimental animals were given ECS (80 mA for 250 msec) at 0, 15, 20, 25, 27.5, 30, 32.5, 35, 40, or 45 min after the CS. Only animals given ECS both within the CS-UCS interval and in close temporal proximity to the UCS (within 5 min) showed a significant, although limited, disruption of learning. At least two explanations are possible. The first is that apart from its toxicity, LiCl may also possess amnesic properties which interact with those of the ECS. Alternatively, ECS may have impaired the ability of the animals to fully experience the lithium-induced illness.
D000818:Animals; D002712:Chlorides / Q000506:poisoning*; D003214:Conditioning, Classical / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D004597:Electroshock; D008094:Lithium / Q000506:poisoning*; D018021:Lithium Chloride; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D051381:Rats; D013649:Taste / Q000187:drug effects*
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride