An early effect of cortisol, previous to its glycogenogenic action.
Cortisol produces a glycogenogenic effect 5 hours after intraperitoneal injection to 3 day old chicks. This effect is dependent on protein synthesis because it can be blocked by antibiotics such as actinomycin D. On the other hand, there is a previous glycogenolytic effect 45 minutes after cortisol administration which is independent of protein synthesis. Thyroid hormones produce a similar early effect as has been previously shown. However, the observed glycogenolysis after cortisol injection is not correlated with an enhancement in the liver cAMP levels.
D000818:Animals; D002645:Chickens; D000242:Cyclic AMP / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects; D008112:Liver Glycogen / Q000378:metabolism*; D013997:Time Factors
D008112:Liver Glycogen; D003609:Dactinomycin; D000242:Cyclic AMP; D006854:Hydrocortisone