Pharmacological activity of leukotrienes A4, B4, C4 and D4 on selected guinea-pig, rat, rabbit and human smooth muscles.
The myotropic activity of leukotrienes A4, B4, C4, D4 and histamine has been evaluated on selected smooth muscle preparations. LTA4, B4, C4 and D4 were several times more potent than histamine on the guinea-pig lung parenchymal strip, while on the guinea-pig trachea, LTB4 was less active. The guinea-pig ileum either in segments or in strips of longitudinal muscles responses well to LTC4, LTD4 and histamine but not to LTA4 and LTB4. Rat and rabbit lung parenchymal strip showed very little sensitivity for leukotrienes whereas human parenchymal strips and bronchi were nearly as sensitive as the guinea-pig lung.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007082:Ileum / Q000187:drug effects; D017572:Leukotriene A4; D007975:Leukotriene B4; D008168:Lung / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000494:pharmacology*; D013045:Species Specificity; D014132:Trachea / Q000187:drug effects
D001095:Arachidonic Acids; D017572:Leukotriene A4; D013189:SRS-A; D007975:Leukotriene B4; D006632:Histamine