Control of recurrent lower urinary tract infection in the postmenopausal woman.
There were 5 postmenopausal women with severe recurrent cystitis who were placed on a protocol of intravaginal estrogen in an effort to control infection. Before therapy all patients had colonization of the vagina by 1 or more species of Enterobacteriaceae and an associated elevation of vaginal pH greater than 5.2 (normal range 4.0 to 4.5). After acute antibiotic treatment and continuous low dose intravaginal estrogen all 5 patients showed a return of vaginal pH to the normal range and disappearance of vaginal bacterial pathogens. Of the 5 women 4 have had no further urinary tract infection off antibiotics and on low dose intravaginal estrogen. One patient had a urinary tract infection in association with a flare in colitis, which was controlled with reinstitution of antibiotics and high dose intravaginal estrogen therapy.
D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use; D003556:Cystitis / Q000517:prevention & control; D004756:Enterobacteriaceae Infections / Q000517:prevention & control*; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008593:Menopause; D008875:Middle Aged; D012008:Recurrence; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014621:Vagina
D000892:Anti-Infective Agents, Urinary; D004966:Estrogens, Conjugated (USP)