Rat dopaminergic function in the retina during aging.
Parameters of dopaminergic transmission were studied in the retina of mature (3-4 months) and aged (23-24 months) rats. In the retina of senescent rats were found significantly higher dihydroxyphenylacetic acid (DOPAC) levels and a higher number of (3H-)spiroperidol binding sites. We detected also an increase of (3H)- methionine-enkephalin binding sites. The changes in the density of (3H)-spiroperidol and (3H)-Metenkephalin binding sites in the retina are opposite to those observed in the brain of aged rats.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis*; D000375:Aging; D000818:Animals; D001665:Binding Sites; D003342:Corpus Striatum / Q000032:analysis / Q000502:physiology; D004745:Enkephalins / Q000032:analysis; D008297:Male; D010648:Phenylacetates / Q000032:analysis*; D051381:Rats; D011954:Receptors, Dopamine / Q000032:analysis*; D011957:Receptors, Opioid / Q000032:analysis; D012160:Retina / Q000032:analysis / Q000502:physiology*
D004745:Enkephalins; D010648:Phenylacetates; D011954:Receptors, Dopamine; D011957:Receptors, Opioid; D015102:3,4-Dihydroxyphenylacetic Acid