[A study of three potential antidepressants (amineptin, mianserin and nomifensin) on the cardiovascular system and isolated intestine (author's transl)].
We studied the effects on the cardiovascular system and isolated intestine of three potential antidepressants : amineptin, nomifensin and mianserin. 1) No animals died in spite of doses well above the therapeutic range, evidencing the good tolerance of the compounds. 2) Effects on heart rate were variable; the only significant effect was cardioacceleration seen with mianserin in doses above 5 mg/kg. 3) The only significant effect on the auriculoventricular refractory period was recorded with mianserin. 4) Amineptin was the only compound that increased blood pressure. 5) Auriculoventricular conduction was slowed with mianserin in doses above 10 mg/kg. 6) On isolated rat duodenum, mianserin was spasmogenic in concentrations above 100 microgram/100 ml. 7) in comparison to tricyclic antidepressants, these three compounds carry only few risks of adverse side-effects.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003986:Dibenzocycloheptenes / Q000494:pharmacology; D004285:Dogs; D004386:Duodenum / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D008803:Mianserin / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009627:Nomifensine / Q000494:pharmacology; D051381:Rats
D000928:Antidepressive Agents; D003986:Dibenzocycloheptenes; D009627:Nomifensine; D008803:Mianserin; C011597:amineptin
Etude des effects cardiaques et sur l'intestin isolé de l'amineptine, la miansérine et la nomifensine.