title: A two-part study of the aetiological role of rotavirus in intussusception.
abstract: The aetiology of intussusception is ill-defined, with viruses being incriminated as one of many possible aetiological agents. A two-part study was performed by us to investigate the aetiological role of rotavirus in intussusception. Retrospective epidemiological data revealed a negative correlation between the incidence of rotaviral gastroenteritis and the incidence of intussusception. A prospective investigation employing electronmicroscopy, enzyme-linked immunosorbent assay (ELISA), and immunofluorescence studies of faeces and fluorescent antibody studies of sera demonstrated evidence of rotavirus infection in only 2 of 24 children with intussusception. No evidence was forthcoming in this study of an aetiological role of rotavirus in intussusception.
mesh_terms: D000208:Acute Disease; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D005759:Gastroenteritis / Q000453:epidemiology; D006801:Humans; D007443:Intussusception / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D011446:Prospective Studies; D012087:Reoviridae; D012189:Retrospective Studies; D012401:Rotavirus / Q000276:immunology; D014777:Virus Diseases