Comparative in-vitro activity of selected new beta-lactam antimicrobials against Neisseria gonorrhoeae.
Four new beta-lactam antimicrobials, ceftriaxone, cefotiam, cefonicid, and mecillinam, were evaluated in vitro against 72 beta-lactamase-negative and 26 beta-lactamase-positive isolates of Neisseria gonorrhoeae. Ceftriaxone was the most active of the antimicrobials tested. It inhibited all isolates, regardless of beta-lactamase activity, at a concentration of less than or equal to 0.015 microgram/ml. Cefotiam and cefonicid were also active against both groups but not as active as ceftriaxone. Both groups of N gonorrhoeae showed a high degree of resistance against mecillinam.
D000560:Amdinocillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002435:Cefamandole / Q000031:analogs & derivatives / Q000494:pharmacology; D015790:Cefonicid; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000494:pharmacology; D015310:Cefotiam; D002443:Ceftriaxone; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002435:Cefamandole; D015790:Cefonicid; D002443:Ceftriaxone; D015310:Cefotiam; D001618:beta-Lactamases; D002439:Cefotaxime; D000560:Amdinocillin