Angiotensin-converting enzyme in hypercalcaemic disorders.
Serum angiotensin-converting enzyme (SACE) was elevated (mean +/- S.D. 55.2 +/- 19.8 U/ml) in 11 patients with hypercalcaemia due to sarcoidosis, whereas it was within the normal limits ((20.0 +/- 5.2 U/ml) in 23 patients with other hypercalcaemic conditions. Among these, 16 had primary hyperparathyroidism and a SACE level of 18.6 +/- 4.7 U/ml, significantly lower than in healthy controls (24.4 +/- 6.2 U/ml). In 7 patients with hypercalcaemia due to malignancies or prolonged immobilization SACE was 21.8 +/- 5.9 U/ml. A weakly positive correlation was found between SACE and S-calcium in hypercalcaemic sarcoidosis patients but not in the other patients or in a control group of 144 consecutive sarcoidosis patients. sarcoidosis with hypercalcaemia seems to be associated with a very high prevalence of elevated SACE. Especially when sarcoidosis is suspected to be the cause of hypercalcaemia, SACE measurement may be useful as a rapid diagnostic guide.
D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000201:enzymology* / Q000209:etiology; D006961:Hyperparathyroidism / Q000150:complications / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D012507:Sarcoidosis / Q000150:complications / Q000201:enzymology*
D003404:Creatinine; D007703:Peptidyl-Dipeptidase A; D002118:Calcium