Presence of adrenocorticotropin-potentiating activity in a calcitonin preparation derived from porcine thyroid glands.
A calcitonin preparation derived from porcine thyroid glands exhibited potentiating activity on the steroidogenic action not only on ACTH-(1-24) but also of ACTH-(1-18) in isolated rat adrenal cells in vitro. This activity was demonstrated in various molecular weight fractions resulting from gel filtration of the preparation. This preparation also contained minute amount of immunoreactive and biologically active ACTH.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002116:Calcitonin / Q000032:analysis / Q000494:pharmacology*; D004357:Drug Synergism; D013552:Swine; D013961:Thyroid Gland / Q000032:analysis*
D000324:Adrenocorticotropic Hormone; D002116:Calcitonin