The influence of asbestos dust on the oncogenic transformation of C3H10T 1/2 cells.
The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogenic effect of benzo[a]pyrene (BP). This putative synergistic effect was evident when fibres and chemicals were added to cultures as simple mixtures and when BP was adsorbed to the surface of the fibres.
D000818:Animals; D001194:Asbestos / Q000494:pharmacology*; D017639:Asbestos, Amosite; D017638:Asbestos, Crocidolite; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D051379:Mice
D017638:Asbestos, Crocidolite; D017639:Asbestos, Amosite; D001194:Asbestos