Comparative in vitro bactericidal activity of cefonicid, ceftizoxime, and penicillin against group B streptococci.
The minimal inhibitory and bactericidal concentrations for 108 group B streptococcal strains were determined for two new cephalosporins, cefonicid and ceftizoxime, and compared to those of penicillin G. Penicillin G was the most active inhibitory and bactericidal agent. Ceftizoxime was a significantly more active inhibitory and bactericidal agent than cefonicid (P less than 0.0005, P less than 0.025, respectively.
D002435:Cefamandole / Q000031:analogs & derivatives / Q000494:pharmacology*; D015790:Cefonicid; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D015296:Ceftizoxime; D002511:Cephalosporins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D010400:Penicillin G / Q000494:pharmacology*; D010403:Penicillin Resistance; D013292:Streptococcus agalactiae / Q000187:drug effects*
D002511:Cephalosporins; D002435:Cefamandole; D015790:Cefonicid; D015296:Ceftizoxime; D002439:Cefotaxime; D010400:Penicillin G