Cyanide and its relationship to nervous suffering. Physiopathological aspects of intoxication.
On the basis of personal results in man and laboratory animal, we examined some aspects of acute and chronic cyanide intoxication: physiopathological aspects, hydroxocobalamin's therapeutic action in treating acute intoxications and neurotoxic sufferings due to cyanide, and hydroxocobalamin's biological action in decreasing the level of free cyanide appearing in blood and urine, a few days after sciatic nerve clamping in rabbits.
D000818:Animals; D003486:Cyanides / Q000378:metabolism / Q000506:poisoning*; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use*; D008658:Inactivation, Metabolic; D009902:Optic Neuritis / Q000188:drug therapy / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology*; D011190:Potassium Cyanide / Q000378:metabolism / Q000633:toxicity; D011817:Rabbits; D012584:Sciatic Nerve / Q000378:metabolism; D012907:Smoking
D003486:Cyanides; D011190:Potassium Cyanide; D006879:Hydroxocobalamin