title: Disturbances of fertility in female mice 99Sr-contaminated as foetuses.
abstract: Pregnant CBA-mice were intravenously injected with 90Sr doses of between 46 and 740 kBq per animal. Their female descendants were mated to untreated CBA-males during a period of 7 months and the reproductive capacity was investigated, i.e. the number of litters born as well as the number of young per female. At the end of the mating period the females were killed and their ovaries microscopically analysed regarding the number of remaining oocytes and follicles. A presumptive correlation between the manifested decrease of the reproductive capacity and the microscopically observed injury was analysed. The fertile conditions of the in utero treated females seemed not affected by 90Sr doses below 370 kBq per dam, although the microscopic examination revealed that 90Sr amounts of 46.3 kBq reduced the total number of oocytes and follicles by one third.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D005260:Female; D005298:Fertility / Q000528:radiation effects*; D008098:Litter Size / Q000528:radiation effects; D051379:Mice; D008808:Mice, Inbred CBA; D009865:Oocytes / Q000528:radiation effects; D010053:Ovary / Q000528:radiation effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011829:Radiation Dosage; D012098:Reproduction / Q000528:radiation effects; D013326:Strontium Radioisotopes / Q000009:adverse effects*
chemical_list: D013326:Strontium Radioisotopes