Selective increases in the density of cerebellar beta-1-adrenergic receptors.
Destruction of noradrenergic neurons by 6-hydroxydopamine or chronic blockade of beta-adrenergic receptors with propranolol increased the density of beta 1-adrenergic receptors two-fold in rat cerebellum but had no effect on the density of beta 2-adrenergic receptors. The results suggest that even through beta 1 receptors comprise only 5-10% of the total number of Beta-adrenergic receptors in the cerebellum they are the receptors specifically innervated by noradrenergic neurons and they may thus be the physiologically important receptors.
D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D007700:Kinetics; D009638:Norepinephrine / Q000378:metabolism; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; C011878:iodohydroxybenzylpindolol; D011433:Propranolol; D010869:Pindolol; D009638:Norepinephrine; D004837:Epinephrine