OKA-SK-RIT Varicella vaccine for "primary" and for booster vaccinations.
In seronegative children--healthy and immunocompromised--and in seronegative adults, we have limited but very promising results--no side reactions and good antibody-conversions with clinical protection. Because--in spite of positive humoral antibodies--10 to 20% of people over the age of 50 have a negative cell-mediated immune response against VZ and are therefore presumed Zoster patients, VZ-booster vaccinations were done in this age group. A significant increase in humoral antibodies can be induced at least in half of these elderly. In 23 elderly with a negative specific cell-mediated immunity against VZ, a booster vaccination induced a strong positive cell-mediated immune response in 9 and no response in 5.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000917:Antibody Formation; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007117:Immunization, Secondary; D008875:Middle Aged; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology*
D014765:Viral Vaccines