Abolition by preventive action of calcitonin of vitamin D3-stimulated gluconeogenesis in rat kidney.
The effects of vitamin D3, 1-alpha-OH D3 and calcitonin treatment on the rate of glucose synthesis in rat renal cortex slices were studied. The rate of glucose synthesis was significantly increased in animals treated with vitamin D3 and 1-alpha-OH D3 as compared to the control. The increase in the rat of glucose synthesis observed after vitamin D3 and 1-alpha-OH D3 treatment was abolished after administration of calcitonin in doses normalizing the serum calcium level. The obtained data point to a correlation between the serum calcium level observed in vivo and the ability to synthesize glucose measured in vitro in renal cortex slices.
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002762:Cholecalciferol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004336:Drug Antagonism; D005943:Gluconeogenesis / Q000187:drug effects*; D006728:Hormones / Q000494:pharmacology; D007672:Kidney Cortex / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D006728:Hormones; D002762:Cholecalciferol; D002116:Calcitonin