Selective immunosuppressive effects of measles virus infection.
The antibody response to diphtheria toxoid by cultured tonsil cells was suppressed by measles virus, which productively infected a small percentage of both T and B lymphocytes. However, infection of cultures spontaneously secreting antibody and immunoglobulin (with Herpes simplex virus) or measles virus did not result in immunosuppression. Immunosuppression by measles virus may thus be attributed to a selective effect on the inductive phase of the response and suggest that infection of immunoglobulin-producing B lymphocytes does not alter the ability of these cells to secrete antibody.
D000293:Adolescent; D000914:Antibodies, Viral / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008457:Measles / Q000276:immunology*; D008459:Measles virus / Q000254:growth & development / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology / Q000382:microbiology; D018139:Simplexvirus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral; D004168:Diphtheria Toxoid