Tumor-induced hypoglycemia: a result of ectopic insulin production.
A 73-year-old woman with a pelvic tumor of nerve cell origin who presented with recurrent episodes of hypoglycemia was demonstrated to have inappropriately elevated plasma insulin and hypoglycemia. The tumor contained Insulin (RIA), proinsulin and secretory type of granules. Removal of the tumor promptly produced hyperglycemia. Also no islet cell tumor was found in the pancreas, suggesting the tumor as the site of ectopic insulin production.
D007516:Adenoma, Islet Cell / Q000150:complications*; D000368:Aged; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007340:Insulinoma / Q000150:complications* / Q000601:surgery; D009362:Neoplasm Metastasis; D009384:Paraneoplastic Endocrine Syndromes / Q000209:etiology* / Q000601:surgery; D010386:Pelvic Neoplasms / Q000150:complications* / Q000601:surgery
D007328:Insulin