Reduced Coxsackie antibody titres in type 1 (insulin-dependent) diabetic patients presenting during an outbreak of Coxsackie B3 and B4 infection.
The potential role of antecedent viral infection in the pathogenesis of Type 1 (insulin-dependent) diabetes was investigated by measuring antibody titres to several viruses in serum obtained at the time of diagnosis of diabetes. An outbreak of Coxsackie B4 infection followed by a wave of Coxsackie B3 and B5 infections occurred in Seattle during the time viral serology was obtained in the diabetic patients. Antibody titres to Cocksackie B5 and Influenza A and B viruses were comparable in diabetics and matched control subjects, but antibody titres to Cocksackie B3 and B4 were lower in the diabetics and a low antibody titre to Coxsackie B3/B4 was associated with a significantly increased relative risk of diabetes.
D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D003384:Coxsackievirus Infections / Q000453:epidemiology* / Q000276:immunology; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D004196:Disease Outbreaks; D029822:Enterovirus B, Human / Q000276:immunology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D009975:Orthomyxoviridae / Q000276:immunology
D000914:Antibodies, Viral; D007328:Insulin