Common model of normal cell differentiation and oncogenesis based on the mutation--recombination effects of transposable genetic elements and of provirus states.
Cell differentiation would result from a sequence of mutation--recombination events that occur in quantal cell cycles, initiating cell lineages. The cytogenomic proviruses--transposable elements ensemble would represent the mutation--recombination equipment of differentiation. Carcinogenesis, as a consequence of multicausally induced mutation--recombination events, would likewise occur in a particular quantal cell cycle resulting in the malignant cell lineage. Superposing the environmental causes of malignancy over those of genetic diseases, the model suggests common prevention methods.
D000818:Animals; D005075:Biological Evolution; D002453:Cell Cycle; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D004260:DNA Repair; D004251:DNA Transposable Elements; D005814:Genes, Viral; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009857:Oncogenes; D011995:Recombination, Genetic
D004251:DNA Transposable Elements