Gaucher's disease and glioblastoma multiforme in two siblings: a clinicopathologic study.
The clinical and pathologic features of two brothers with the adult form of Gaucher's disease, both of whom developed cerebral glioblastoma multiforme, are presented. Neither patient had a long-standing neurologic disorder, and morphologic evidence of nervous system glucocerebroside storage was not seen. Despite the known increased incidence of malignancy in Gaucher's disease, a review of the literature and of sixty-two Mayo Clinic cases of adult onset Gaucher's disease revealed only one other instance of the association with glioma. The significance of the relationship is unknown.
D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology*; D005776:Gaucher Disease / Q000145:classification / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005909:Glioblastoma / Q000209:etiology / Q000473:pathology*; D005963:Glucosylceramides / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011073:Polyamines
D005963:Glucosylceramides; D011073:Polyamines; C033506:3,3'-methyliminobis(N-methylpropylamine)