Alteration of benzo(a)pyrene metabolism by acute ethanol or corticosterone.
The effect of acute ethanol (3 g/kg and 5 g/kg) or corticosterone (12.5 mg/kg) on benzo(a)pyrene metabolism was measured in microsomes from 3-methylcholanthrene pretreated rats. BAP disappearance was inhibited 34% at 5 g/kg but unaltered at 3 g/kg ethanol. Corticosterone administration inhibited BAP metabolism 53%. In adrenalectomized (ADX) rats, alcohol or CS did not decrease BAP metabolism (compared to untreated ADX rats). However, corticosterone in vitro inhibited BAP metabolism in a dose-related fashion in washed microsomes from untreated rats. These results demonstrate that acute ethanol and corticosterone administration alter benzo(a)pyrene metabolism. Furthermore, the inhibition requires an intact adrenal.
D000315:Adrenalectomy; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism*; D003345:Corticosterone / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001580:Benzopyrenes; D001564:Benzo(a)pyrene; D000431:Ethanol; D003345:Corticosterone