Pale eosinophilic inclusions simulating ground-glass appearance of cells of hepatocellular carcinoma.
Pale eosinophilic inclusions simulating ground-glass appearance were observed in cells of hepatocellular carcinoma. They were round or elliptical in shape, and their size was about 14 micrometers in diameter. Light eosinophilia and fine granulation with homogeneous appearance were delineated from other cellular materials. They were negative for HBsAg, blood plasma proteins including alpha 1-antitrypsin, and alpha-fetoprotein by immunohistochemical stainings. Ultrastructurally, they were well-demarcated and consisted of homogeneous finely granular matrix. Histological, histochemical and ultrastructural features were different from several intracellular inclusions hitherto reported on hepatocellular carcinoma. These changes may represent a deposition of secretory proteinous materials in cells of hepatocellular carcinoma, but their chemical and antigenetical content could not be identified.
D000941:Antigens / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D008113:Liver Neoplasms / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D000941:Antigens; D006514:Hepatitis B Surface Antigens