[Biological properties of the MK 35 mutant of Aujeszky's disease virus (Pseudorabies virus)].
Clinical, virological, and morphological studies were carried out with a total of 15 twenty-day-old pigs and 55 rabbits of 2.5 kg body weight. All were experimentally infected with a new mutant, MK 35 (3.5 x 10(7) plaque forming units) of the pseudorabies virus. The changes taking place in the test animals were followed up in their dynamics from the first to the thirtieth day after injecting the virus. No clinical signs speaking of the development of Aujeszky-s disease were noted, neither was the virus isolated from the tonsils, lungs, lymph nodes, and the central nervous system of the treated animals. Histologically, there was in the central nervous system a slightly expressed nonsuppurative meningoencephalitis which was most clearly manifested on the fourth day after the animals were infected. Later on the changes appeared to be more slightly visible, and on the 8-10th day they were no longer seen. At the 48th hour following the inoculation and up to the end of the experiment eosinophil leukocytes were present in the tonsils, lymph nodes, and spleen of all infected animals as well as within the parenchyma of the adrenal glands of the pigs only. The presence of eosinophil leukocytes in the enumerated organs of the test animals is referred to as the morphologic manifestation of immunogenesis--the result of an enhanced defense status of the host induced by the MK 35 mutant of the pseudorabic virus.
D000818:Animals; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007114:Immunization; D009154:Mutation; D011557:Pseudorabies / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D013552:Swine; D014774:Virulence
Biologichni svoĭstva na mutant MK 35 na virusa na bolestta na Aueski (pseudorabies virus).