The tumor-protective effect of selenium in an experimental model.
The possibility of a tumor-protective effect of selenium on the growth of benzpyrene-induced sarcoma was studied in an assay with Balb/c mice. The animals received 4 parts/10(6) selenium in their drinking water for 12 months prior to subcutaneous injection of benzpyrene to induce sarcomas. In contrast to unpretreated controls, the selenium-exposed animals developed significantly less and smaller tumors in a given time. These results are compared to those of other authors. Several mechanisms for selenium influence on benzpyrene metabolism are discussed.
D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism; D001711:Biotransformation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012513:Sarcoma, Experimental / Q000517:prevention & control*; D012643:Selenium / Q000494:pharmacology*
D001580:Benzopyrenes; D001564:Benzo(a)pyrene; D012643:Selenium