[Correlation between renal compensatory hypertrophy and urinary sodium excretion in the ACTH treated rat].
In the rat, renal compensatory hypertrophy (RCH) is enhanced by the administration of ACTH (beta 1-24 corticotrophin) given at a dose of 18 micrograms/100 g. body weight/d. after uninephrectomy. In the rats drinking tap water, the enhancement of RCH by ACTH occurs without any significant change in urinary Na+ excretion. But, in the animals drinking a NaCl solution (9 g/l), ACTH determines a polyuria with hypernatriuria and a more striking increase of RCH positively correlated with the urinary Na+ excretion.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D003366:Cosyntropin / Q000494:pharmacology*; D005260:Female; D006984:Hypertrophy / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine*
D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D012964:Sodium
Corrélation entre l'hypertrophie rénale compensatrice et le débit urinaire de sodium chez le rat traité par l'ACTH.