Oral converting enzyme inhibitor in malignant hypertension.
Malignant hypertension, which developed in a 9-year-old boy after an episode of haemolytic uraemic syndrome, could not be controlled with antihypertensive agents. However, treatment with oral converting enzyme inhibitor (captopril) was effective in controlling the blood pressure and it averted bilateral nephrectomy. No adverse effects from the drug were noted.
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D006463:Hemolytic-Uremic Syndrome / Q000150:complications; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*
D000806:Angiotensin-Converting Enzyme Inhibitors; D011392:Proline; D002216:Captopril