Stimulation of brain Na+, K+-ATPase by norepinephrine in vivo: prevention by receptor antagonists and enhancement by repeated stimulation.
The role of alpha 1- and beta-noradrenergic receptors in the stimulation of the K+-p-nitrophenylphosphatase activity and ouabain binding associated with rat brain Na+, K+-ATPase by acute or repeated yohimbine were examined. Repeated yohimbine increased enzyme activity and ouabain binding by about 25%; this was prevented by the alpha 1-receptor antagonist prazosin and decreased by the beta-antagonist propranolol. Pretreatment with repeated yohimbine increased the stimulation of enzyme activity by acute yohimbine while the stimulation was prevented by prazosin pretreatment.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D015016:Yohimbine / Q000494:pharmacology
D011941:Receptors, Adrenergic; D015016:Yohimbine; D011433:Propranolol; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine; D011224:Prazosin