title: Thorotrast-associated cholangiocarcinoma: an epidemiologic and clinicopathologic study.
abstract: Six cases of Thorotrast-associated cholangiocarcinoma (TACC) are studied and compared with eight previously reported cases as well as with cases of non-TACC. TACC shares some epidemiologic features both with non-TACC as well as Thorotrast-associated angiosarcoma (TAAS) but appears to occur in younger patients than non-TACC. There is an apparent increased prevalence of both benign and malignant thyroid disease in the current group of patients with TACC; previous epidemiologic studies have not identified this phenomenon. Thorotrast-associated hepatic fibrosis was present in all 14 TACC cases; otherwise, both non-TACC and TACC are clinically and morphologically similar. Bile duct dysplasia and/or transition to adenocarcinoma, which occurred in all the AFIP cases, are seldom described in case reports of either TACC or non-TACC; in the current study they served to validate the intrahepatic origin of the tumors.
mesh_terms: D002759:Adenoma, Bile Duct / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D001652:Bile Ducts / Q000473:pathology; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D013911:Thorium Dioxide / Q000009:adverse effects* / Q000032:analysis; D013959:Thyroid Diseases / Q000150:complications; D013997:Time Factors
chemical_list: D013911:Thorium Dioxide