Lack of interference of guanosine with ribavirin aerosol treatment of influenza A infection in mice.
Guanosine or guanosine 5'-monophosphate did not reduce the protective effect of ribavirin aerosol in influenza virus A/Aichi/68 H3N2 infection of mice. Both compounds partially interfered with the action of a wide range of ribavirin concentrations against influenza virus A/WSN replication in cell culture.
D000336:Aerosols; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006151:Guanosine / Q000008:administration & dosage / Q000494:pharmacology*; D006157:Guanosine Monophosphate / Q000008:administration & dosage / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects; D007274:Injections, Intraperitoneal; D051379:Mice; D008815:Mice, Inbred Strains; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D012254:Ribavirin / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D012263:Ribonucleosides / Q000008:administration & dosage*
D000336:Aerosols; D012263:Ribonucleosides; D006151:Guanosine; D012254:Ribavirin; D006157:Guanosine Monophosphate