title: Outbreaks of egg-drop syndrome-1976 in Japan and its etiological agent.
abstract: A condition similar to egg-drop syndrome-1976 (EDS-76) occurred in 14 broiler breeding flocks in 2 farms in Japan from December 1978 to January 1980, and it was diagnosed as EDS-76 by serologic and virological investigations. Egg production fell suddenly when the hens were 30 to 55 weeks of age, and the depression lasted 3 to 7 weeks. Production fell 6 to 25%. Depressed egg production was accompanied by the laying of shell-less, soft-shelled, and thin-shelled eggs associated with loss of egg-shell pigment. Eleven isolates of hemagglutinating adenovirus were isolated from cloacal swabs (10 isolates) and a uterus (1 isolate)  of hens in one farm. One isolate, cloned and named JPA-1, had the same antigenicity in serologic tests and the same biological and physicochemical properties as the BC14 strain of EDS-76 virus.
mesh_terms: D000257:Adenoviridae Infections / Q000175:diagnosis / Q000382:microbiology / Q000662:veterinary*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D000259:Aviadenovirus / Q000276:immunology / Q000302:isolation & purification / Q000648:ultrastructure; D002645:Chickens; D004196:Disease Outbreaks / Q000662:veterinary*; D004531:Eggs; D005260:Female; D007564:Japan; D008854:Microscopy, Electron; D011201:Poultry Diseases / Q000175:diagnosis* / Q000382:microbiology; D013577:Syndrome / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral