title: Phase I-II study of isotopic immunoglobulin therapy for primary liver cancer.
abstract: A phase I-II study of isotopic immunoglobulin therapy was performed in 18 patients with primary liver cancer; 14 were evaluable for toxicity. The patients received a dose of 37-157 millicuries of 131I-labeled antibody. The dose-limiting factor appears to be hematologic toxicity, especially thrombocytopenia. An objective antitumor effect was seen in six of nine patients who were evaluable for response. Present results suggest that further clinical studies with isotopic immunoglobulin are indicated.
mesh_terms: D002759:Adenoma, Bile Duct / Q000532:radiotherapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000532:radiotherapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage; D007136:Immunoglobulins / Q000008:administration & dosage*; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007970:Leukopenia / Q000209:etiology; D008099:Liver / Q000000981:diagnostic imaging / Q000528:radiation effects; D008113:Liver Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010362:Patients' Rooms; D011829:Radiation Dosage; D011867:Radioisotope Teletherapy / Q000379:methods; D011877:Radionuclide Imaging; D013921:Thrombocytopenia / Q000209:etiology
chemical_list: D007074:Immunoglobulin G; D007136:Immunoglobulins; D007457:Iodine Radioisotopes