Intervention with epinephrine in hypotension associated with mastocytosis.
The occurrence of the episodes of vasodilatory hypotension can be a life-threatening manifestation of systemic mastocytosis. This article describes the reversal by epinephrine of episodes of severe hypotension in two hospitalized patients with mastocytosis. Recognition of the efficacy of epinephrine in hypotension associated with mastocytosis can be important when other methods fail to restore hemodynamic stability.
D000368:Aged; D000818:Animals; D003404:Creatinine / Q000652:urine; D000242:Cyclic AMP / Q000502:physiology; D004285:Dogs; D004837:Epinephrine / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000652:urine; D006801:Humans; D007022:Hypotension / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008407:Mast Cells / Q000502:physiology; D011457:Prostaglandins D / Q000652:urine; D051381:Rats; D014582:Urticaria Pigmentosa / Q000150:complications*
D011457:Prostaglandins D; C035860:9-hydroxy-11,15-dioxo-2,3,18,19-tetranorprost-5-ene-1,20-dioic acid; D006632:Histamine; D003404:Creatinine; D000242:Cyclic AMP; D004837:Epinephrine