title: Effect of fiber on breath hydrogen response and symptoms after oral lactose in lactose malabsorbers.
abstract: The effect of ingesting cellulose, pectin, and psyllium with orally administered lactose in water or milk was tested in six lactose malabsorbers. Breath hydrogen tests were used to evaluate lactose malabsorption and mouth-to-cecum transit times. Addition of psyllium significantly reduced the breath hydrogen response, and symptoms in each subject; whereas, less diminution of expired hydrogen was seen after cellulose or pectin was added. The effect of each fiber on gastric emptying rates of an equal volume liquid meal was evaluated in three volunteers. Pectin had no effect, while the cellulose and psyllium modestly delayed emptying at approximately 30 min.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001944:Breath Tests; D004043:Dietary Fiber / Q000494:pharmacology*; D004347:Drug Interactions; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D007785:Lactose / Q000494:pharmacology*; D007787:Lactose Intolerance / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008892:Milk; D010368:Pectins / Q000494:pharmacology; D011620:Psyllium / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004043:Dietary Fiber; D006859:Hydrogen; D011620:Psyllium; D010368:Pectins; D007785:Lactose