title: Dietary fiber, lipid metabolism, and atherosclerosis.
abstract: Despite the physiochemical complexity of dietary fibers (plant cell walls) and their individual components, there is substantial epidemiologic, clinical, and experimental evidence that these dietary components may have a role in modifying certain risk factors in coronary heart disease. Particulate fibers, such as wheat bran, do not appear to significantly alter plasma lipids or lipoprotein distributions in humans, or the atherogenicity of diets in experimental animals. Dietary fibers found in fruits, legumes, and vegetables, in contrast, show more definitive responses. Among the fiber isolates, the gelling and mucilaginous fibers, such as pectins and guar gum, predictably decrease circulating lipids in humans and animals and increase excretion of fecal metabolites of cholesterol, the bile acids. These fibers and fiber components can be shown to influence luminal solubility of lipids and the extent of lymphatic absorption of both cholesterol and triglyceride. In addition, these same fibers are effective in reducing postprandial levels of glucose, insulin, and other hormones. These direct effects on lipid absorption, and secondary effects of glucose and insulin on hepatic and peripheral lipoprotein metabolism, can account for many of the hypolipidemic responses to specific dietary fibers or their components, and may be of long-term consequence in coronary heart disease.
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D001647:Bile Acids and Salts / Q000502:physiology; D002784:Cholesterol / Q000378:metabolism; D004043:Dietary Fiber / Q000378:metabolism*; D005782:Gels; D006801:Humans; D050356:Lipid Metabolism
chemical_list: D001647:Bile Acids and Salts; D004043:Dietary Fiber; D005782:Gels; D002784:Cholesterol