S-100 protein in soft-tissue tumors derived from Schwann cells and melanocytes.
In soft tissues outside the central nervous system, S-100 protein is found normally only in Schwann cells. Using the peroxidase-antiperoxidase immunohistochemical method S-100 was also found in tumors derived from Schwann cells and melanocytes, including neurofibromas, neurilemomas, granular cell myoblastomas, cutaneous nevi, and malignant melanomas. S-100 was not detected in malignant Schwannomas, neuroblastomas, oat cell carcinomas, medullary carcinomas of the thyroid, paragangliomas, or meningiomas. S-100 was also absent from neoplasms of soft tissues not usually considered to arise from cells of neural crest origin. S-100 appears to be a useful marker for identifying neoplasms derived from Schwann cells and melanocytes.
D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008544:Melanocytes / Q000032:analysis*; D008545:Melanoma / Q000032:analysis / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis; D009379:Neoplasms, Muscle Tissue / Q000032:analysis / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009442:Neurilemmoma / Q000032:analysis / Q000473:pathology; D009447:Neuroblastoma / Q000032:analysis / Q000473:pathology; D009464:Neuroma, Acoustic / Q000032:analysis / Q000473:pathology; D009506:Nevus / Q000032:analysis / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000032:analysis / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis*; D012583:Schwann Cells / Q000032:analysis*; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000032:analysis* / Q000473:pathology
D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D009418:S100 Proteins