Corticotropin inhibiting peptide and a synthetic beta-melanotropin analog inhabit the lipolytic activity of corticotropin and melanotropins.
Lipolysis in isolated rabbit fat cells induced by beta-melanotropin, alpha-melanotropin and corticotropin was inhibited by both corticotropin inhibiting peptide and [Gly10]-beta-melanotropin. Corticotropin inhibiting peptide was a more potent antagonist than [Gly10]-beta-melanotropin.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D008066:Lipolysis / Q000187:drug effects*; D009074:Melanocyte-Stimulating Hormones / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones