Calcium: calmodulin and cancer.
When several fast-growing Morris hepatoma tissue lines are compared with normal adult liver tissue, the following observations are made: calmodulin activity is increased in the cytoplasm and decreased in the membrane of the tumor cells. Total calcium is increased three- to fivefold in the tumors. Cyclic AMP phosphodiesterase activity is increased, whereas cyclic GMP phosphodiesterase activity is decreased. In addition, several of the fast-growing Morris hepatoma tissue lines have a new calcium-binding protein that is not observed in adult liver tissue. It is probable that the Ca2+-calmodulin complex is very active in these rapidly growing tumors.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D017317:Annexin A6; D002118:Calcium / Q000032:analysis*; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats
D017317:Annexin A6; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D002118:Calcium