Effect of furosemide upon endolymph potassium concentration.
Chinchillas were anesthetized with ketamine (40 mg/kg i.m.) and endocochlear potential (EP) and potassium concentration in endolymph (Ke+) were determined in control animals and in animals injected with various doses of furosemide (25, 50 or 100 mg/kg i.v.) by means of microelectrodes inserted into scala media. Control EP and Ke+ in the chinchilla were 81.3 +/- 3.8 mV and 158.5 +/- 3.2 mequiv./l, respectively. Following injection of furosemide, a dose-related fall in EP and Ke+ was observed. However, the EP declined much more rapidly than the Ke+, and recovered more quickly than the latter. The recovery of Ke+ tended to lag behind the EP recovery. The debate over whether potassium transport into endolymph and endocochlear potential generation are related or independent events is discussed in the light of recent literature and the present study.
D000818:Animals; D001693:Biological Transport, Active; D002682:Chinchilla / Q000502:physiology*; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D004710:Endolymph / Q000032:analysis / Q000187:drug effects*; D005665:Furosemide / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D007761:Labyrinthine Fluids / Q000187:drug effects*; D008839:Microelectrodes; D011188:Potassium / Q000378:metabolism*
D007473:Ion Channels; D005665:Furosemide; D011188:Potassium