[Dependence of blood platelet aggregation capacity on agents affecting the intrathrombocyte Ca2+ content].
The effect of agents changing absorption and redistribution of Ca2+ in platelets on platelet aggregation was studied. It was shown that inhibition of intercellular Ca2+ absorption by verapamil and tetracain block of intracellular Ca2+ redistribution decrease platelet aggregation. A joint action of verapamil and tetracain increase the inhibition of aggregation. EDTA decreases platelet aggregation affecting platelet regulatory mechanisms associated with the action of cAMP and probably directed at a decrease in the platelet cytoplasmic Ca2+ content.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D003994:Bucladesine / Q000494:pharmacology; D002118:Calcium / Q000097:blood*; D002413:Cations, Divalent / Q000097:blood; D004492:Edetic Acid / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D002413:Cations, Divalent; D000244:Adenosine Diphosphate; D003994:Bucladesine; D004492:Edetic Acid; D002118:Calcium
Zavisimost' agregatsionnoĭ sposobnosti krovianykh plastinok ot vozdeĭstviĭ na soderzhanie vnutritrombotsitarnogo Ca2+.