Effect of acyclovir and presence of cellular and viral thymidine kinase activity in herpes simplex virus infected cells. Brief report.
Herpes simplex type 1 (HSV-1) infected human lung fibroblasts show a higher viral thymidine kinase activity than infected African green monkey kidney cells. This may partly account for the higher antiviral activity of acyclovir in the former cells.
D000212:Acyclovir / Q000494:pharmacology*; D000818:Animals; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000494:pharmacology; D002455:Cell Division; D002460:Cell Line; D002522:Chlorocebus aethiops; D003600:Cytosol / Q000201:enzymology; D006801:Humans; D007065:Idoxuridine / Q000494:pharmacology; D010746:Phosphonoacetic Acid / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D013937:Thymidine Kinase / Q000378:metabolism*
C020235:brivudine; D013937:Thymidine Kinase; D001973:Bromodeoxyuridine; D007065:Idoxuridine; D010746:Phosphonoacetic Acid; D000212:Acyclovir