[Juxtaglomerular apparatus and interstitial cells of the kidney medulla after the administration of certain drugs and use of hyperbaric oxygenation].
Electron microscopy was used to examine the status of the juxtaglomerular apparatus (JGA) and interstitial cells (IC) 3 and 24 hours after administration of furosemide (10 mg/kg), indomethacin (10 mg/kg), venoruton (500 mg/kg) and trental (100 mg/kg), and after 1,6 an 12 sessions of hyperbaric oxygenation. To evaluate objectively the results of examining the JGA, use was made of a method devised by the authors of a mathematical appraisal of granulation from the density of the epithelioid cells. Granulation of 50 IC from each animal was calculated on semi-thin araldite sections stained methylene blue-azur II-fuchsin. The results indicate that all the types of exposure including hyperbaric oxygenation produced JGA activation whose degree varied depending on the time elapsed after exposure. An apparently great increase in the JGA activity was detected after injection of furosemide and indomethacin. All the drugs with the exception of furosemide entailed granule accumulation after 3 hours, followed by the recovery of their amount after 24 hours. Furosemide injection produced a reverse effect.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000818:Animals; D005665:Furosemide / Q000494:pharmacology*; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives / Q000494:pharmacology; D006931:Hyperbaric Oxygenation; D007213:Indomethacin / Q000494:pharmacology*; D007606:Juxtaglomerular Apparatus / Q000187:drug effects* / Q000648:ultrastructure; D007679:Kidney Medulla / Q000187:drug effects* / Q000648:ultrastructure; D011817:Rabbits
D006896:Hydroxyethylrutoside; D005665:Furosemide; C005865:troxerutin; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D007213:Indomethacin
Sostoianie iukstaglomeruliarnogo apparata i interstitsial'nykh kletoh mozgovogo veshchestva pochek posle vvedeniia nekotorykh farmakologicheskikh preparatov i primeneniia giperbricheskoĭ oksigenatsii.