Pharmacokinetics of ceftizoxime in patients undergoing hemodialysis.
Serum pharmacokinetics of 1 g ceftizoxime were studied in eight patients undergoing chronic haemodialysis. Arterial blood samples were collected at 3, 60, 120, 180 and 240 minutes and before the next dialysis 2-3 days after injection of ceftizoxime. Three minutes after injection the serum levels were 122 +/- 8.4 microgram/ml and 19.4 +/- 1.7 microgram/ml at the end of the dialysis. Mean elimination half-life under haemodialysis was 2.1 hours. Serum concentrations ranged from 4.9 to 13 microgram/ml two to three days after the haemodialysis.
D000328:Adult; D000368:Aged; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000378:metabolism; D015296:Ceftizoxime; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D015296:Ceftizoxime; D002439:Cefotaxime