Interaction of feline sarcoma virus (FeSV) and mycoplasma.
A factor present in the supernatant of an established human glioma cell line U-251 MG strongly suppresses feline sarcoma virus (FeSV) focus forming activity on feline embryo fibroblasts. The factor was identified as mycoplasma arginini. The enriched mycoplasma fraction had no cytpathogenic effect on the glioma cells or on the embryonic feline indicator cells. An antiserum prepared against this strain of mycoplasma abolished the inhibition. The exact mechanism is not known but arginine depletion in the medium seems to be an important factor.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D002415:Cats; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D005910:Glioma / Q000378:metabolism; D006801:Humans; D007612:Kanamycin / Q000494:pharmacology; D009174:Mycoplasma / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D012190:Retroviridae / Q000378:metabolism*; D005253:Sarcoma Viruses, Feline / Q000378:metabolism*
D007612:Kanamycin; D001120:Arginine