Electron microscopic study on the interaction of Sendai virus with liposomes containing glycophorin.
The interaction of liposomes containing glycophorin, a major sialoglycoprotein of human erythrocytes, with Sendai virus was studied by freeze-fractures and negative staining electron-microscopy. Viral envelopes were absorbed on liposomal membranes at 0 degrees C. When the temperature was shifted up to 37 degrees C, the viral envelopes fused with the liposomal membranes (envelope fusion). Particles representing viral membrane components formed clusters on liposomal membranes after incubation for more than 1 h at 37 degrees C.
D005614:Freeze Fracturing; D006021:Glycophorins / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism*; D008854:Microscopy, Electron; D010222:Parainfluenza Virus 1, Human / Q000378:metabolism* / Q000648:ultrastructure; D012795:Sialoglycoproteins / Q000378:metabolism*
D006021:Glycophorins; D008081:Liposomes; D012795:Sialoglycoproteins