title: Adenovirus serotypes isolated from ocular infections in London.
abstract: During the period 1973-8 700 adenoviruses were isolated from the eyes of patients presenting at Moorfields Eye Hospital. Of these, 678 were serotyped by a neutralisation test. Twenty-one different serotypes were identified. Serotype 3, 7, and 10 accounted for 68% of the isolates, 4, 8, 15 (15/29), and 19 for 25%, and the other 14 serotypes for 7%. Community outbreaks of ocular infections by adenovirus 3, 4, 7, 10, and 15 (15/29) were observed. Outbreaks with adenovirus 3, 7, and 10 appeared to continue for 2 years or more, whereas outbreaks with 4 and 15 (15/29) were restricted to one year or less. Hospital outbreaks by adenovirus 8 and 19 were also recorded. During the same period 18 of these 21 adenovirus serotypes were isolated from the nonocular sites (mainly respiratory tract) in 7804 cases. There was a close association in the distribution of adenovirus 1, 2, 3, 5, and 6 in the ocular and nonocular sites. No such association was observed for adenovirus serotypes 4, 8, 10, 15 (15/29), and 19.
mesh_terms: D000257:Adenoviridae Infections / Q000382:microbiology*; D000258:Adenovirus Infections, Human / Q000453:epidemiology / Q000382:microbiology*; D000260:Adenoviruses, Human / Q000145:classification / Q000302:isolation & purification*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003228:Conjunctiva / Q000382:microbiology; D003231:Conjunctivitis / Q000209:etiology / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008131:London; D008297:Male; D008875:Middle Aged; D012137:Respiratory System / Q000382:microbiology; D012621:Seasons; D012703:Serotyping; D012737:Sex Factors; D013997:Time Factors