Significant increases of cyclic AMP and alkaline phosphatase in bronchoalveolar lavage fluids of sheep exposed to asbestos.
Exposure to asbestos for six months caused a significant increase of adenosine 3',5'-cyclic monophosphate (cAMP) levels (2-fold in bronchoalveolar lavage (BAL) fluids of sheep with no significant change in guanosine 3',5'-cyclic monophosphate (cGMP) and alkaline phosphatase (AP) activity. When exposure was prolonged for another 3 month-period, the increase in cAMP levels persisted and was accompanied by a 4-fold stimulation of AP activity, and enzyme associated with the surfactant fraction of BAL fluids.
D000469:Alkaline Phosphatase / Q000032:analysis*; D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D001980:Bronchi / Q000032:analysis* / Q000187:drug effects; D000242:Cyclic AMP / Q000032:analysis*; D008297:Male; D011650:Pulmonary Alveoli / Q000032:analysis* / Q000187:drug effects; D012756:Sheep; D007507:Therapeutic Irrigation
D001194:Asbestos; D000242:Cyclic AMP; D000469:Alkaline Phosphatase