[Effect of polymyxin B on the conductivity of negatively charged bilayer lipid membranes].
Effect of polymyxin B on the planar bilayer lipid membranes (BLM) formed from synthetic phosphatidic acid has been studied. The addition of cholesterol to phospholipid in molar ratio 1 : 2 was followed by an increase of BLM conductance from 2 x 10(-8) to 3 x 10(-7) Ohm-1 cm-2. It was suggested that the observed increase of conductance was due to the fluidity of the membrane matrix in the presence of cholesterol. It was shown that 10(-6)--10(-5) M polymyxin slightly affected the conductance of BLM from phosphatidic acid. It was found that polymyxin increased conductance of negatively charged BLM modified by palmitic acid from 10(-8) to 10(-6) Ohm-1 cm-2.
D004563:Electrochemistry; D007477:Ions / Q000378:metabolism*; D008051:Lipid Bilayers; D019308:Palmitic Acid; D010169:Palmitic Acids; D010539:Permeability; D010712:Phosphatidic Acids; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*
D007477:Ions; D008051:Lipid Bilayers; D010169:Palmitic Acids; D010712:Phosphatidic Acids; D011113:Polymyxins; D019308:Palmitic Acid; D011112:Polymyxin B
Vliianie polimiksina B na provodimost' otritsatel'no zarazhennykh bisloĭnykh lipidnykh membran.