Compound 48/80-induced permeability change in liposomal membrane.
The action of compound 48/80 (a mixture of condensation products of p-methoxy-N-methylphenethylamine with formaldehyde) on liposomal membranes was studied by means of K+-loaded liposomes and a K+ ion-selective electrode. Prompt efflux of K+ was detected when 48/80 was added to the negatively charged liposome suspension, while the monomer of 48/80, p-methoxy-N-methylphenethylamine, did not release K+ from the same liposomes. The mechanism for the action of 48/80 is discussed in comparison with that of a polymyxin, well known as an antibiotic acting on bacterial membranes.
D007700:Kinetics; D008081:Liposomes; D008564:Membrane Potentials; D008954:Models, Biological; D010539:Permeability; D011113:Polymyxins; D011188:Potassium; D011663:Pulmonary Surfactants; D003189:p-Methoxy-N-methylphenethylamine
D008081:Liposomes; D011113:Polymyxins; D011663:Pulmonary Surfactants; D003189:p-Methoxy-N-methylphenethylamine; D011188:Potassium