Loss of the short-lived suppressive function of peripheral leukocytes in feline retrovirus-infected cats.
Normal feline peripheral blood mononuclear cells demonstrated increased phytomitogen blast transformation after a 24 hr delay in mitogen addition as compared to 0 hr mitogenesis. Increased stimulation after 24 hr which is not due to enhancing factors accumulating in the culture medium has been attributed to a short-lived suppressor cell which loses its effect after 24 hr in culture. This short-lived suppressive phenomenon was studied in normal specific-pathogen-free cats and compared to experimental animals infected with retrovirus (FeLV). Experimental cats demonstrated a subsequent loss of this function following acquisition of a persistent viremia.
D000818:Animals; D002415:Cats; D003208:Concanavalin A / Q000494:pharmacology; D066298:In Vitro Techniques; D005256:Leukemia Virus, Feline; D007942:Leukemia, Experimental / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors; D014412:Tumor Virus Infections / Q000276:immunology
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A