Inhibitory effect of retinoids on Epstein-Barr virus induction in Raji cells.
Induction of Epstein-Barr virus (EBV) early antigen after treatment with various combinations of croton oil and n-butyrate was markedly inhibited by retinoids 7901, 7902, Ro 10-9359 and Ro 11-1430. Possible administration of retinoids to virus capsid antigen IgA antibody-positive individuals in high-risk areas for nasopharyngeal carcinoma to prevent EBV activation and development of this cancer is discussed.
D002087:Butyrates; D003436:Croton Oil; D005050:Etretinate / Q000494:pharmacology; D004854:Herpesvirus 4, Human / Q000378:metabolism*; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000517:prevention & control; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology*
D002087:Butyrates; D014801:Vitamin A; D014212:Tretinoin; D005050:Etretinate; D003436:Croton Oil; C033564:retinoid 7901; C033565:retinoid 7902; C010832:motretinide