Increased urinary excretion of cyclic nucleotides in X-linked hypophosphatemic (Hyp) mice.
Hyp mice, a model for human X-linked hypophosphatemia, had elevated urinary cyclic AMP, cyclic GMP, and magnesium excretion compared to normal mice. The data suggest a renal origin of the urinary cyclic nucleotides. No significant differences in plasma cyclic AMP and cyclic GMP were observed between genotypes.
D000818:Animals; D000242:Cyclic AMP / Q000652:urine*; D006152:Cyclic GMP / Q000652:urine*; D004195:Disease Models, Animal; D005260:Female; D007015:Hypophosphatemia, Familial / Q000652:urine*; D008274:Magnesium / Q000652:urine; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D012737:Sex Factors; D014960:X Chromosome
D000242:Cyclic AMP; D006152:Cyclic GMP; D008274:Magnesium