title: [Comparative evaluation of the effects of intravenous administration of cimetidine and ranitidine on several cardiovascular parameters].
abstract: We have compared the effects of intravenous administration of cimetidine and ranetidine on some cardiovascular parameters. Five healthy volunteers received both cimetidine (3, 5 mg/Kg) and ranetidine (1, 5 mg/Kg). Heart rate, blood pressure and PEP/LVET were recorded at baseline and 5, 10, 30, 45 minutes after administration of both drugs. Intravenous administration of cimetidine and ranetidine did not induce any significant alterations in cardiovascular variables.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005663:Furans / Q000008:administration & dosage / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011899:Ranitidine; D013997:Time Factors
chemical_list: D005663:Furans; D006146:Guanidines; D002927:Cimetidine; D011899:Ranitidine
vernacular_title: Valutazione comparativa degli effetti della somministrazione e.v. di cimetidina e ranitidina su alcuni parametri cardiovascolari.