title: [Kinetic and clinical studies on a new cephalosporin: Cefotiam].
abstract: Kinetic and clinical evaluation of cefotiam, a new cephalosporin, is reported. It was found that the drug is rapidly distributed to the tissues. Equilibrium between tissues and plasma is reached in about an hour. Some 90-91% of the dose administered is excreted in the urine, and accumulation does not occur. A clinical cure was obtained in 27 of a series of 35 patients (77.1%). Improvement was observed in 7 cases (20%). The antibiotic proved ineffective in the remaining cases (2.8%). Tolerance was excellent and there were no side-effects worthy of note.
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use / Q000652:urine; D015310:Cefotiam; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012505:Sarcina / Q000187:drug effects; D014018:Tissue Distribution
chemical_list: D015310:Cefotiam; D002439:Cefotaxime
vernacular_title: Ricerca cinetica e clinica su una nuova cefalosporina: Cefotiam.