A possible mechanism for elevation of glucose-6-phosphatase activity in kidney and liver of fluoride-treated rats.
Glucose-6-phosphatase (EC 3.1.3.9) activity in kidney and liver was found to be markedly elevated 3 hr after a single large dose of fluoride (NaF, 35 mg/kg, i.p.). The increases in renal and hepatic glucose-6-phosphatase activity were completely suppressed by adrenalectomy. Moreover, the increments were markedly suppressed by injection of dibenamine as an alpha-adrenergic blocker or by injection of propranolol as a beta-adrenergic blocker.
D000315:Adrenalectomy; D000818:Animals; D003983:Dibenzylchlorethamine / Q000494:pharmacology; D005459:Fluorides / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008566:Membranes / Q000201:enzymology; D008861:Microsomes / Q000201:enzymology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology*
D003983:Dibenzylchlorethamine; D012969:Sodium Fluoride; D011433:Propranolol; D005952:Glucose-6-Phosphatase; D005459:Fluorides