title: Histopathology of avian adenovirus group II splenomegaly of chickens.
abstract: Chickens were infected with an avian adenovirus group II isolate previously obtained from chickens exhibiting splenomegaly in commercial broiler flocks. The isolate was inoculated orally in 6-week-old experimental chickens, which were euthanatized and necropsied 6 days postinoculation. The primary gross lesions found were splenomegaly and splenic mottling. Numerous tissues from 12 chickens were taken for histologic evaluation. Histologic lesions included splenic reticuloendothelial cell hyperplasia with intranuclear inclusions. Lymphocytic degeneration was seen in the lungs of most chickens examined. Lung hemorrhage and edema with endothelial disruption and congestion of pulmonary arterioles were found less frequently. The splenic lesions in the chickens were similar to those seen in turkeys naturally infected with hemorrhagic enteritis, and the lung lesions resembled those seen in pheasants naturally infected with marble spleen disease.
mesh_terms: D000257:Adenoviridae Infections / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000259:Aviadenovirus / Q000145:classification; D002645:Chickens; D007421:Intestine, Small / Q000473:pathology; D008168:Lung / Q000473:pathology; D011201:Poultry Diseases / Q000473:pathology*; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000473:pathology / Q000662:veterinary*