title: Long-term, low-dose treatment with pivmecillinam alone and in combination with pivampicillin in patients prone to recurrent bacteriuria.
abstract: The results of three separate studies aimed at evaluating the efficacy of long-term, low-dose treatment with pivmecillinam alone, and in combination with pivampicillin, in patients prone to recurrent bacteriuria, are presented. Overall, pivmecillinam and pivmecillinam/pivampicillin appeared to be equally effective, both clinically and bacteriologically, in a group of elderly subjects treated for 6 months. Pivmecillinam was also used successfully for up to 1 year in 10 out of 12 children in whom prophylactic therapy was indicated. The various regimens employed were without any significant toxic effects and were well tolerated.
mesh_terms: D000368:Aged; D000561:Amdinocillin Pivoxil / Q000008:administration & dosage* / Q000633:toxicity; D000667:Ampicillin / Q000031:analogs & derivatives*; D001437:Bacteriuria / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010397:Penicillanic Acid / Q000008:administration & dosage*; D010917:Pivampicillin / Q000008:administration & dosage*; D012008:Recurrence
chemical_list: D010917:Pivampicillin; D000561:Amdinocillin Pivoxil; D000667:Ampicillin; D010397:Penicillanic Acid