title: A multivariate analysis of the prognosis after surgical treatment of malignant soft-tissue tumors.
abstract: Ninety-seven patients who had received their primary and definitive surgical treatment for a soft-tissue sarcoma during the years 1956--1976 were studied with respect to local recurrence, metastasis, and survival. The aim of the treatment was to eradicate the tumor while preserving good function. The influence of host and tumor properties and different diagnostic and surgical procedures on the prognosis was studied by means of nonparametric multivariate analysis. Ninety-four percent of the tumors were located in the extremities. Malignant fibrous histiocytoma was the most common histologic type. A four-grade scale of histologic malignancy was used. Eighty-eight percent of the tumors were Grade III or IV. In 85% of the patients with an extremity lesion, local extirpation was carried out. The overall local recurrence rate was 21.7% and in 76 patients who underwent an adequate surgical procedure it was 6.6%. The overall five-year survival rate was 59%. The survival depended on the local control of the primary tumor, which was related to the adequacy of the surgical procedure and to the histologic grade of malignancy. No patient with a Grade I or II tumor died. The five-year survival rate for patients with Grade III tumors was 68% and for patients with Grade IV tumors 47%.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005121:Extremities; D005260:Female; D005354:Fibrosarcoma / Q000601:surgery; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000601:surgery; D006801:Humans; D007890:Leiomyosarcoma / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009442:Neurilemmoma / Q000601:surgery; D011336:Probability; D011379:Prognosis; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000601:surgery*