Comparison of the effects of age and phorbol myristate acetate on the beta-adrenergic system in mouse epidermis.
The beta-adrenergic hormone responsiveness of mouse epidermis exhibited an age-dependent decrease. The 3-4-fold loss of response to isoproterenol was seen between 3 and 6 months of age, and the response remained at a depressed level through 18 months of age. No differences were seen between either the number or binding affinities of epidermal beta-receptors in 2- and 12-month-old animals. The skin tumor promoter, phorbol myristate acetate, inhibited the beta-adrenergic response independently of age.
D000375:Aging; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D010704:Phorbols; D000242:Cyclic AMP; D007545:Isoproterenol; D013755:Tetradecanoylphorbol Acetate