Receptor-independent catabolism of low density lipoprotein. Involvement of the reticuloendothelial system.
In this study we examine the effects of intravenous ethyl oleate emulsions on the metabolism of native and cyclohexanedione-modified human low density lipoprotein in rabbits. Treatment produced a highly significant fall in receptor-independent catabolism as measured by the fractional clearance rate of cyclohexanedione-modified low density lipoprotein. Receptor-dependent catabolism (the difference between the fractional clearance rates of native and cyclohexanedione-modified low density lipoprotein) was variably affected with some animals showing a decrease in receptor activity. These data suggest that the reticuloendothelial system makes a substantial contribution to receptor-independent low density lipoprotein catabolism in the rabbit.
D000818:Animals; D003512:Cyclohexanones / Q000494:pharmacology; D004655:Emulsions; D006801:Humans; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000378:metabolism*; D012157:Mononuclear Phagocyte System / Q000378:metabolism*; D009829:Oleic Acids / Q000494:pharmacology; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000378:metabolism; D011973:Receptors, LDL; D014304:Triolein / Q000494:pharmacology
D003512:Cyclohexanones; D004655:Emulsions; D008077:Lipoproteins, LDL; D009829:Oleic Acids; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; D014304:Triolein; C018031:1,2-cyclohexanedione; C033180:ethyl oleate