Genetic control of Rous sarcoma regression in inbred lines of chickens.
The fate of tumours induced by PR-RSV-C was investigated in highly inbred chicken lines congenic at the B complex, the major histocompatibility complex of the chicken. The results demonstrated that Rous sarcoma regression in congenic CB and CC lines was controlled by a gene within the B region of the chromosome. Another congenic pair of the WA and WB lines also differed in the ability to regress RSV-induced tumours and a gene within the B complex also appeared to have a significant role in the regression of Rous sarcomas.
D000818:Animals; D002645:Chickens / Q000235:genetics; D006649:Histocompatibility Antigens / Q000032:analysis / Q000235:genetics*; D009365:Neoplasm Regression, Spontaneous; D001357:Sarcoma, Avian / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology
D006649:Histocompatibility Antigens