[New case of rhinoentomophtoromycosis. Cure by ketoconazole].
A new case of rhino-entomophtoromycosis due to Conidiobolus coronatus is added to the ten others observed in Cameroon, among the 62 african cases described. The patient, a man 27 years old, has an elephantiasis form with nasal obstruction, hypertrophy of lips, globulous forms of cheeks, giving a monstrous facies. After failure of KI and intravenous miconazole, therapeutic success was obtained with oral ketoconazole. After improvement with 400 mg daily, the doses were increased to 600 mg to obtain mycological and clinical cure with good clinical and biological tolerance; important eosinophilia related to the destruction of the fungus was observed. Restorative surgery was necessary to render a more human aspect of the monstrous lesions of face.
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D004604:Elephantiasis / Q000209:etiology; D004773:Entomophthora; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007654:Ketoconazole; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D009668:Nose Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010879:Piperazines / Q000627:therapeutic use*
D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D007654:Ketoconazole
Nouveau cas de rhino-entomophtoromycose. Guérison par le kétoconazole.