title: Chemical interactions with herpes simplex type 2 virus: enhancement of transformation by norharman.
abstract: The effects of the comutagen norharman on herpes simplex virus type 2 growth transformation was studied in 3T3 cells. Pre-exposure but not post-exposure of the cells to 0.5 to 10 micrograms of norharman per ml of cell culture media resulted in a nearly three-fold enhancement in transforming activity. These results suggest that certain environmental chemicals may interact with cells creating an increased possibility of transformation by herpes viruses.
mesh_terms: D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D002243:Carbolines; D002472:Cell Transformation, Viral / Q000187:drug effects*; D002478:Cells, Cultured; D006247:Harmine / Q000031:analogs & derivatives / Q000633:toxicity*; D051379:Mice; D018139:Simplexvirus / Q000472:pathogenicity*
chemical_list: D000470:Alkaloids; D002243:Carbolines; D006247:Harmine; C010262:norharman