Some effects of gamma-linolenic acid on cultured human oesophageal carcinoma cells.
Cells of two continuous human oesophageal carcinoma lines were treated by the addition of gamma-linolenic acid (GLA) at concentrations of 10-60 micrograms/ml culture medium. After 7 days of exposure to GLA, pronounced morphological changes became evident and culminated in cell death. GLA-mediated effects were time- and dose-dependent and varied slightly with the degree of histological differentiation of the lines tested. These findings may have clinical implications.
D000970:Antineoplastic Agents; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004938:Esophageal Neoplasms / Q000473:pathology*; D006801:Humans; D008042:Linolenic Acids / Q000494:pharmacology*; D013997:Time Factors; D017965:gamma-Linolenic Acid
D000970:Antineoplastic Agents; D008042:Linolenic Acids; D017965:gamma-Linolenic Acid