title: Mutant of Bordetella pertussis which lacks ability to produce filamentous hemagglutinin.
abstract: Mutant cultures that lacked the ability to produce filamentous hemagglutinin were obtained by UV irradiation of Bordetella pertussis strain 18-323. Various biological activities of these mutants were compared with those of the parent culture. It was found that the leukocytosis-promoting, histamine-sensitizing, and mouse-protecting activities of the mutants were similar to those of the parent strain but that the virulence to mice was lower. The results seemed to rule out fimbrial hemagglutinin as a protective antigen when the ability to protect mice was measured by the intracerebral challenge test.
mesh_terms: D000371:Agglutination; D001427:Bacterial Toxins / Q000096:biosynthesis; D001886:Bordetella pertussis / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006388:Hemagglutinins / Q000276:immunology*; D006632:Histamine / Q000494:pharmacology; D007964:Leukocytosis / Q000209:etiology; D009154:Mutation
chemical_list: D001427:Bacterial Toxins; D006388:Hemagglutinins; D006632:Histamine