Ultrastructure of peripheral lymphocytes in generalized ceroid-lipofuscinosis. Report of a case.
Electron microscopic observation was made on the peripheral blood cells obtained from a 4-year-old boy with generalized ceroid-lipofuscinosis (GCL), and two kinds of significant inclusions were found in the cytoplasm of lymphocytes. One was ceroid-lipofuscin accompanied with the fingerprint pattern, and the other was a lamellar body which showed the concentric lamellar structure or the myelin figure. Ceroid-lipofuscin was found in 40% of peripheral lymphocytes. It is important in diagnosing GCL that ceroid-lipofuscin can be detected with high incidence in lymphocytes of peripheral blood.
D002566:Ceroid / Q000097:blood / Q000378:metabolism*; D002675:Child, Preschool; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008064:Lipidoses / Q000097:blood* / Q000175:diagnosis; D008062:Lipofuscin / Q000097:blood / Q000378:metabolism*; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D010860:Pigments, Biological / Q000378:metabolism*
D002566:Ceroid; D008062:Lipofuscin; D010860:Pigments, Biological