Cellular retinoid-binding proteins in cultured human and mouse myeloid leukemia cells.
Retinoic acid and retinol induced functional and morphological differentiation of human promyelocytic leukemia cells  (HL-60) into mature granulocytes, but did not induce functional or morphological differentiation of mouse myeloid leukemia cells (M1). Cellular retinoic acid-binding protein, but not retinol-binding protein, was detected on HL-60 cells. Neither binding protein could be detected on M1 cells. These results suggest that retinoic acid-binding protein may be necessary for induction by retinoids of functional and morphological differentiation of myeloid leukemia cells.
D000818:Animals; D002352:Carrier Proteins / Q000032:analysis*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002478:Cells, Cultured; D004790:Enzyme Induction; D006801:Humans; D007951:Leukemia, Myeloid / Q000032:analysis*; D015470:Leukemia, Myeloid, Acute / Q000032:analysis* / Q000473:pathology; D051379:Mice; D009113:Muramidase / Q000096:biosynthesis; D009363:Neoplasm Proteins / Q000032:analysis*; D051381:Rats; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins / Q000032:analysis*; D014212:Tretinoin / Q000494:pharmacology
D002352:Carrier Proteins; D009363:Neoplasm Proteins; D018168:Receptors, Retinoic Acid; D012177:Retinol-Binding Proteins; D014212:Tretinoin; D009113:Muramidase