Resistance to prolonged irradiation in mice influenced by thyroid hormones and chemical radiation protectors.
After the end of 10 and 21 days' treatment of mice with dried thyroid gland (0.6 g/100 g diet) the effect of some radiation protectors against prolonged irradiation (38 mGy/min) increased. The combination of propranolol, phenobarbital and cystamine was more effective than a mixture of cystamine and 5-methoxytryptamine both in mice fed on a normal and a thyroid gland diet. A reduced oxygen consumption after the application of protectors reflected the degree of protection. The number of thrombocytes in peripheral blood increased after the end of thyroid treatment, which indicated a possible shift in the differentiation of stem cells in favour of megakaryocytes.
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000528:radiation effects; D003538:Cystamine / Q000494:pharmacology; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D010634:Phenobarbital / Q000494:pharmacology; D010976:Platelet Count; D011433:Propranolol / Q000494:pharmacology; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D013963:Thyroid Hormones; D008735:5-Methoxytryptamine; D011433:Propranolol; D003538:Cystamine; D010634:Phenobarbital