title: Blood pressure changes: oestrogens in climacteric women.
abstract: An analysis of data from a prospective study which compared the effect of conjugated equine oestrogens (Premarin) with that of piperazine oestrone sulphate (Ogen) demonstrated that postmenopausal women who received conjugated equine oestrogens had a higher rate of a rise in blood pressure and development of hypertension than women who received piperazine oestrone sulphate. Conversely, a greater proportion of women who took oestrone sulphate had a fall in blood pressure than those who took equine oestrogens. A hypothesis to account for these differences, based on the known potent biological action of equine oestrogen, is developed.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003971:Diastole / Q000187:drug effects; D004967:Estrogens / Q000009:adverse effects / Q000494:pharmacology*; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D005500:Follow-Up Studies; D006736:Horses; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007022:Hypotension / Q000139:chemically induced; D008593:Menopause; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects / Q000494:pharmacology; D011446:Prospective Studies; D013599:Systole / Q000187:drug effects
chemical_list: D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D010879:Piperazines