title: Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
abstract: The transforming protein sequences translated from the Rous avian and Moloney murine sarcoma virus src genes are shown to be related to the catalytic chain of bovine cAMP-dependent protein kinase (ATP:protein phosphotransferase, EC 2.7.1.37). The avian transforming protein, also a protein kinase, shows greatest homology with the bovine protein kinase in the carboxyl-terminal half, where the protein kinase activity is localized. Moreover, lysine occurs in the inferred transforming protein sequences at the position homologous with the proposed ATP-binding lysine of the bovine protein kinase. This relationship is consistent with the hypothesis that the src genes originated in the host genomes, in which they are members of a superfamily of distantly related protein kinases that are normal constituents of mammalian cells. In the host, these sequences are much more highly conserved than in the viruses.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000201:enzymology; D005075:Biological Evolution; D002417:Cattle; D000242:Cyclic AMP; D008979:Moloney murine leukemia virus / Q000201:enzymology; D015688:Oncogene Protein pp60(v-src); D011494:Protein Kinases; D014764:Viral Proteins
chemical_list: D014764:Viral Proteins; D000242:Cyclic AMP; D011494:Protein Kinases; D015688:Oncogene Protein pp60(v-src)