title: Two types of synaptic facilitation recorded in pyramidal cells of in vitro hippocampal slices from guinea pigs.
abstract: PyramidaL cells in CA1 hippocampus show two types of increase in the excitatory postsynaptic potential (EPSP) during paired pulse stimulation of the afferent fibres in stratum radiatum. For 15-300 ms interstimulus intervals, both the initial slope and the peak amplitude of the EPSP are increased, which is mainly due to an increased excitatory synaptic current. For 300 ms-2 s intervals, the predominant change is an increase in the peak amplitude. The latter type of facilitation is caused by a decrease in a superimposed inhibitory postsynaptic potential (IPSP).
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D004558:Electric Stimulation; D005071:Evoked Potentials; D006168:Guinea Pigs; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission