On the mechanism of red blood cell shape change and release of spectrin-free vesicles.
Changes in the negative change densities on the outside (by raising the phosphatidic acid concentration) or on the inside of the red blood cell membrane (by a breakdown of the polyphosphoinositides and a concomitant diacylglycerol production) do not explain the last step in echinocytosis, the release of spectrin-free vesicles.
D000255:Adenosine Triphosphate / Q000097:blood; D001457:Anion Exchange Protein 1, Erythrocyte; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000648:ultrastructure*; D004912:Erythrocytes / Q000648:ultrastructure*; D006801:Humans; D008565:Membrane Proteins / Q000097:blood* / Q000378:metabolism*; D010712:Phosphatidic Acids / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000097:blood; D013049:Spectrin / Q000378:metabolism*
D001457:Anion Exchange Protein 1, Erythrocyte; D001798:Blood Proteins; D008565:Membrane Proteins; D010712:Phosphatidic Acids; D010716:Phosphatidylinositols; D013049:Spectrin; D000255:Adenosine Triphosphate; D004492:Edetic Acid; D002118:Calcium