Stimulation of prostaglandin synthesis in rat cerebral cortex via a beta-adrenoceptor.
1. Synthesis of prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2 alpha) in rat cerebral cortex slices is increased by beta-adrenoceptor agonists. 2. Phenylephrine, an alpha-adrenoceptor agonist, has no effect while oxymetazoline increased PGF2 alpha only. 3. PG synthesis stimulation by noradrenaline (NA) was prevented by beta- but not by alpha-adrenoceptor antagonists. 4. Dibutyryl cyclic AMP and inhibitors of cyclic nucleotide phosphodiesterase augment PG synthesis. 5. Stimulation of PG synthesis in rat cerebral cortex by NA is mediated by a beta-adrenoceptor.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003994:Bucladesine / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013565:Sympatholytics / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology
D010726:Phosphodiesterase Inhibitors; D011453:Prostaglandins; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D013565:Sympatholytics; D013566:Sympathomimetics; D003994:Bucladesine; D009638:Norepinephrine