Platelets in primary thrombocythemia: electron microscopic study.
The ultrastructural analysis of platelets from patients with Primary Thrombocythemia (PT) showed some anomalous features. Platelets having structural modifications of their organelles were observed and a decrease in the number of dense bodies was seen. Freeze-fracture analysis of the plasma membrane of platelets from PT patients showed a significant increase in the number of intramembranous particles (IMP).
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000502:physiology / Q000648:ultrastructure*; D002462:Cell Membrane / Q000648:ultrastructure; D005260:Female; D005614:Freeze Fracturing; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009940:Organoids / Q000648:ultrastructure; D013922:Thrombocytosis / Q000097:blood*