Influence of N-methylformamide on the development, the NAD synthesis, and the activity of the ADPR transferase of rat embryos.
When N-methylformamide is administered to rats on the 11th day of pregnancy approximately 50% of the fetuses are resorbed and a reduced weight of the developed animals is found in comparison to the controls on the 21th day (delivery by Caesarian section). The toxic effect is increased by using nicotinamide and methionine. If a combination of these substances is employed practically all fetuses are resorbed. Tryptophan, however, has a considerably protective influence. N-Methylformamide has no influence on the NAD-synthesis induced by nicotinamide or tryptophan. It does, however, inhibits the activity of the ADPR transferase.
D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D005327:Fetal Resorption / Q000139:chemically induced; D005559:Formamides / Q000494:pharmacology*; D008431:Maternal-Fetal Exchange; D008715:Methionine / Q000494:pharmacology; D009243:NAD / Q000096:biosynthesis*; D009713:Nucleotidyltransferases / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan / Q000494:pharmacology
D005559:Formamides; D009243:NAD; D014364:Tryptophan; D008715:Methionine; D011065:Poly(ADP-ribose) Polymerases; D009713:Nucleotidyltransferases; C002950:methylformamide