[Effect of the "memory peptide" ACTH 5-10 on the self-stimulation reaction of rabbits].
Experiments on rabbits were made to study variation in the frequency of the self-stimulation reaction from the lateral hypothalamus under the effect of the corticotropin fragment ACTH5-10. Intraperitoneal administration of the peptide in a dose of 50 micrograms/kg that causes the improved training in different behavioral models produces no significant effect on the mechanism of intracranial positive reinforcement. Intraventricular injection of 5 microliters of 0.9% NaCl leads to a short-term suppression of the self-stimulation reaction. Administration of 50 pcM/kg ACTH5-10 in the same volume of physiological saline completely abolishes the inhibitory action of the intraventricular injection itself.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D007858:Learning / Q000187:drug effects; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits; D012054:Reinforcement, Psychology; D012653:Self Stimulation / Q000187:drug effects*
D010446:Peptide Fragments; C035065:ACTH (5-10); D000324:Adrenocorticotropic Hormone
Vliianie "peptida pamiati" AKTG 5-10 na reaktsiiu samostimuliatsii u krolikov.