[Immunology of beta-adrenergic receptors: a working model of a hormone-mimicking internal image].
Two types of antibodies have been prepared against beta-adrenergic receptors: (1) antibodies against receptor, purified from turkey erythrocyte membranes by affinity chromatography on alprenolol sepharose, and (2) antiidiotypic antibodies raised against the anti-alprenolol immunoglobulins. Both types of antibodies specifically bind to cells which possess beta-adrenergic receptor and mimick the biological effect of the catecholamine hormone: they stimulate basal adenylate-cyclase and enhance adenylate-cyclase activation by catecholamines. The antiidiotypic antibodies only compete with (--)-3H-dihydroalprenolol for binding to the beta-adrenergic receptors on purified turkey erythrocyte membranes. The use of these antibodies as tools for the study of the mechanism of the beta-adrenergic receptor-cyclase complex is discussed.
D000526:Alprenolol / Q000276:immunology; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000235:genetics / Q000276:immunology; D055598:Chemical Phenomena; D002621:Chemistry; D004910:Erythrocyte Membrane / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000235:genetics / Q000276:immunology; D007545:Isoproterenol / Q000494:pharmacology; D008954:Models, Biological; D011941:Receptors, Adrenergic / Q000276:immunology*; D011943:Receptors, Adrenergic, beta / Q000235:genetics / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology*; D014422:Turkeys
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011956:Receptors, Cell Surface; D000526:Alprenolol; D007545:Isoproterenol
Immunologie des récepteurs beta-adrénergiques: un modèle d'étude d'une image interne hormonomimétique.