Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.
Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression.
D000818:Animals; D001483:Base Sequence; D002116:Calcitonin / Q000235:genetics*; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D005786:Gene Expression Regulation; D005796:Genes; D007031:Hypothalamus / Q000378:metabolism; D008954:Models, Biological; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D012326:RNA Splicing; D012332:RNA, Heterogeneous Nuclear / Q000032:analysis; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism
D012332:RNA, Heterogeneous Nuclear; D012333:RNA, Messenger; D002116:Calcitonin; D004247:DNA; D004262:DNA Restriction Enzymes