The failure of an inactivated mink enteritis virus vaccine in four preparations to provide protection to dogs against challenge with canine parvovirus-2.
Four experimental vaccine preparations comprising a strain of mink enteritis virus inactivated by either formalin or beta-propiolactone, and either adjuvanted or nonadjuvanted, failed to stimulate a consistent serum antibody response in 20 vaccinated dogs and failed to protect all but one of these dogs against oral challenge with canine parvovirus-2.
D000818:Animals; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D028301:Feline Panleukopenia Virus / Q000276:immunology*; D005260:Female; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D008297:Male; D010321:Parvoviridae / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014777:Virus Diseases / Q000517:prevention & control / Q000662:veterinary*
D014613:Vaccines, Attenuated; D014765:Viral Vaccines