[cAMP-dependence of phosphorylation of the phosphorylase b kinase of the skeletal muscles of rats during physical exercise and training].
During relative rest of trained rats the phosphorylase b kinase activity is increased by 24% (pH 6.8). Physical load causes an increase of the phosphorylase b kinase activity of untrained and trained rats by 44 and 33%, respectively. The degree of phosphorylase b kinase phosphorylation by a homologous soluble cAMP-dependent protein kinase from the muscles of trained rats at rest is 1.9 times that of the control group. The cAMP-dependent phosphorylation of phosphorylase b kinase of untrained and trained rats under physical load is increased 2.5-fold. The data obtained are indicative of the regulatory role of cAMP-dependent phosphorylation in biochemical adaptation of skeletal muscles when their function is increased.
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000201:enzymology* / Q000502:physiology; D010764:Phosphorylase Kinase / Q000302:isolation & purification / Q000378:metabolism*; D010766:Phosphorylation; D005082:Physical Exertion; D051381:Rats
D000242:Cyclic AMP; D010764:Phosphorylase Kinase
O cAMP-zavisimom fosforilirovanii kinazy fosforilazy b skeletnykh myshts krys pri fizicheskoĭ nagruzke i trenirovke.