Genetic analysis of induction of anti-polyadenylic acid antibodies and xenotropic type-C viruses.
Normal mice can be induced by lipopolysaccharide to produce anti-polyadenylic acid (poly A) antibodies and xenotropic (X-tropic) type-C viruses. To determine whether these traits are genetically linked, high anti-poly A antibody, high virus-producing NZB mice were crossed with low anti-poly A antibody-producing, virus-negative SWR mice. All mice in the F1 generation could be induced by LPS to produce high levels of both anti-poly A antibodies and X-tropic virus. When F1 hybrids were back-crossed to the SWR parent, all offspring were high anti-poly A antibody producers, but one-third of the mice remained virus-negative. These results demonstrate that these two LPS responses of a B lymphocyte are not genetically-linked and the anti-poly A antibody response is multigenic.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology; D003433:Crosses, Genetic; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens / Q000494:pharmacology; D011061:Poly A / Q000276:immunology*; D012190:Retroviridae / Q000254:growth & development*; D014775:Virus Activation
D001323:Autoantibodies; D008070:Lipopolysaccharides; D008934:Mitogens; D011061:Poly A