[Haemophilus influenza infections in infants and mothers. Three cases (author's transl)].
The three cases reported were diagnosed at the time of contamination by direct examination and culture, at birth, of placental tissue, gastric fluid and peripheral specimens. The culture media included a chocolate agar medium favourable to the growth of H. influenzae. One of the isolates was beta-lactamase producer and therefore resistant to the group A penicillins usually prescribed. Determination of the M.I.C.s of eight antibiotics showed that cefotaxime constitutes, for the time being, a suitable alternative to penicillins against such strains. Early detection of H. influenzae perinatal infections make it possible to treat neonates before complications develop. Among the 19 cases published, there were 4 cases of meningitis, 8 cases of septicaemia and 1 case of arthritis.
D000328:Adult; D002439:Cefotaxime / Q000627:therapeutic use; D005260:Female; D006192:Haemophilus Infections / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy; D006193:Haemophilus influenzae / Q000201:enzymology / Q000302:isolation & purification; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D014621:Vagina / Q000382:microbiology; D001618:beta-Lactamases / Q000378:metabolism
D001618:beta-Lactamases; D002439:Cefotaxime
Infections foeto-maternelles à haemophilus influenzae. Trois observations.