Partial characterization of unusual polar steroids in the urine of a child with low renin hypertension.
Analysis of urinary steroids excreted by a 7-year old girl with low renin hypertension following ACTH treatment revealed several unknown steroids, which have been analysed by gas chromatography-mass spectrometry. It is proposed that these steroids are monohydroxylated derivatives of cortisol, cortisone, either or both tetrahydro and allo-tetrahydrocortisol and either or both tetrahydro and allo-tetrahydro-11-deoxycortisol. Further analysis indicated that there are two likely positions for the additional hydroxyl group, either on the A or B ring.
D000324:Adrenocorticotropic Hormone; D002648:Child; D003345:Corticosterone / Q000378:metabolism; D003348:Cortisone / Q000378:metabolism; D003350:Cortodoxone / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D006889:Hydroxycorticosteroids / Q000652:urine*; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000652:urine*; D007536:Isomerism; D012083:Renin / Q000172:deficiency*; D013760:Tetrahydrocortisol / Q000652:urine
D006889:Hydroxycorticosteroids; C009412:tetrahydro-11-deoxycortisol; D013760:Tetrahydrocortisol; D000324:Adrenocorticotropic Hormone; D012083:Renin; D003348:Cortisone; D003345:Corticosterone; D003350:Cortodoxone; D006854:Hydrocortisone