Properties of a Herpes virus-transformed hamster cell line--I. Growth and culture characteristics of sublines of high and low metastatic potential.
A Herpes virus hominis type 2-induced tumour line of the Syrian hamster, designated HSV-2-333-2-26, exhibited a low level of spontaneous metastasis from the primary subcutaneous tumour mass. Two lung foci, met A and met B, were resected and transplanted s.c.; both lines showed an elevated metastatic potential compared with the parent cell line such that all animals inoculated with these cells developed metastatic disease within 40 days after resection of the primary tumour. Neither the rapidity of cell growth in vivo or in vitro, nor anchorage-independent growth or degree of attachment to a solid substrate in vitro are implicated in the altered behaviour of the metastatic cell lines.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002472:Cell Transformation, Viral; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009362:Neoplasm Metastasis; D018139:Simplexvirus