title: [Irreversible generalized pulmonary emphysema resulting from destructive bronchitis and bronchiolitis following adenovirus infection].
abstract: Report of an 1 1/2 year old boy with the typical features of Williams-Campbell syndrome: chest deformity (thorax piriformis), pulmonary hyperinflation, ballooning of the segmental and subsegmental bronchi during inspiration and collapse with expiration. Atelectasis of the left upper lobe after bronchiolitis obliterans. The literature reports 23 patients with Williams-Campbell syndrome. There is every reason to believe that the extensive bronchiectasis are not due primarily to developmental deficiency of the bronchial cartilage, as the most authors assume, but result from destructive changes after inflammation. In our case very likely an adenovirus infection was the cause. The clinical features of the syndrome look like a severe therapy resistant asthma bronchiale.
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications*; D000258:Adenovirus Infections, Human / Q000150:complications*; D001249:Asthma / Q000175:diagnosis; D001987:Bronchiectasis / Q000150:complications; D001990:Bronchiolitis, Viral / Q000150:complications*; D001991:Bronchitis / Q000150:complications*; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D008297:Male; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000209:etiology*; D013577:Syndrome
vernacular_title: Irreversibles generalisiertes Lungenemphysem infolge destruktiver Bronchitis und Bronchiolitis nach Adenovirusinfekt (Williams-Campbell Syndrom).