Biogenic amines and beta-endorphin responses in the rat vas deferens.
1. Recent studies have demonstrated that activation of opioid peptide receptor by beta-endorphin results in a change of bioamines in peripheral tissues. 2. The present results could be interpreted assuming that the action of beta-endorphin, on the smooth muscle of the isolated rat vas deferens, is independent of catecholaminergic, cholinergic and tryptaminergic neurotransmission. 3. There is evidence that it is through a specific opioid 'epsilon-receptor' which have been shown a high degree of affinity for beta-endorphin.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001679:Biogenic Amines / Q000037:antagonists & inhibitors / Q000502:physiology*; D004347:Drug Interactions; D004558:Electric Stimulation; D004723:Endorphins / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014649:Vas Deferens / Q000187:drug effects; D001615:beta-Endorphin
D001679:Biogenic Amines; D004723:Endorphins; D001615:beta-Endorphin; D001285:Atropine; D006220:Haloperidol; D008784:Methysergide; D010646:Phentolamine