title: CNS control of active sodium transport in muscle during progressive hypokalemia in the rat.
abstract: The degree of plasma hypokalemia was graded with the duration of a potassium deficient diet. The intracellular Na+ and K+ contents ([Na]i and [K]i) of the innervated soleus muscle of hypokalemic rats were determined and plotted as a function of plasma K+ concentration following a potassium deficient diet during 1-8 weeks. The progression of plasma hypokalemia was highly correlated with both [Na]i accumulation and [K]i loss in the muscle. Denervation of muscles in the hypokalemic rat resulted in a rapid activation of the Na-pump in the denervated soleus muscle regardless of the degree of plasma hypokalemia. This pump activation in the denervated muscle was chronically maintained throughout the hypokalemia. Restoration of a normal, K+ containing, diet for 4 days in hypokalemic rats resulted in a complete recovery of normal Na+ and K+ contents in both the innervated muscle and plasma, while the [Na]i and [K]i in the denervated muscle was unaffected. The relationship between the CNS-induced inhibition of the muscle Na-pump and the plasma K+ levels in hypokalemic rats is discussed.
mesh_terms: D000818:Animals; D007008:Hypokalemia / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation / Q000378:metabolism*; D011188:Potassium / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D012964:Sodium / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D011942:Receptors, Adrenergic, alpha; D012964:Sodium; D011188:Potassium