title: Vitamin D and its metabolites. Advances in the diagnosis and treatment of rickets.
abstract: Diagnostic and therapeutical uses of vitamin D3 and its metabolites are reviewed. Special emphasis is dedicated to the fetomaternal relationships of 1,25 (OH)2 D3 and 25-OH-D3 at term. The serum levels of 1,25 (OH)2 D3 have been found to be higher in the maternal serum then in the corresponding fetus (85.3 pg/ml and 50.9 pg/ml, respectively). The highest serum levels of 1,25 (OH)2 D3 were found in October and the lowest ones in January showing that there is a dependence on the ultraviolet light. It has been found that there is a correlation between the fetomaternal serum levels of 1,25 (OH)2 D3 and 25-OHD. However, there is no correlation between the serum levels of 1,25 (OH)2 D3 and 25-OHD3, neither in the fetus nor in the mother.
mesh_terms: D000328:Adult; D002112:Calcifediol / Q000097:blood / Q000627:therapeutic use; D002117:Calcitriol / Q000097:blood / Q000627:therapeutic use; D002648:Child; D002762:Cholecalciferol / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000188:drug therapy; D007223:Infant; D007231:Infant, Newborn; D009751:Nutritional Requirements; D011247:Pregnancy; D012279:Rickets / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy*; D012621:Seasons; D014466:Ultraviolet Rays; D014808:Vitamin D Deficiency / Q000628:therapy*
chemical_list: D002762:Cholecalciferol; D002117:Calcitriol; D002112:Calcifediol