Possible mechanism of action of piperazine derivatives on liver mitochondria. I--Effect of p-toluyl m-nitro-piperazine (p-TNP).
The effect of p-toluyl m-nitro-piperazine on energy conservation processes in rat liver mitochondria is presented. The drug showed an inhibitory effect on the three segments of the respiratory chain and on the ATPase system. NADH oxidase and NADH dehydrogenase activity was inhibited 100%. The velocity and amplitude of swelling induced by glutamate, succinate, ascorbate + TMPD, and ATP was significantly changed by p-toluyl m-nitro-piperazine. It was suggested that the general action of the drug on mitochondrial metabolism would be concerning with modifications on mitochondrial membrane.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects; D066298:In Vitro Techniques; D008928:Mitochondria / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D009245:NADH Dehydrogenase / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D013384:Succinate Cytochrome c Oxidoreductase / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
D010879:Piperazines; C033052:(4-toluoyl-3-nitro)piperazine; D013384:Succinate Cytochrome c Oxidoreductase; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D000251:Adenosine Triphosphatases