Pseudosecondary antibody response to LPS induced by toxins for macrophages.
A single dose of bacterial lipopolysaccharide, administered 21 days after mice had been treated with the macrophage toxins carrageenan, or microparticulate crystalline silica, resulted in a secondarytype antibody response. The phenomenon of pseudosecondary responsiveness was investigated to determine the mechanism for its generation. The results showed that generating a pseudosecondary response was T cell dependent; but except for this, it followed the same kinetic and genetic patterns as a true, two dose of antigens, secondary response. It was concluded that pseudosecondary responsiveness resulted from priming the mice by the consequential effects of the macrophage toxins; thereafter, secondary responsiveness to LPS was generated in a normal manner.
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology*; D002351:Carrageenan / Q000494:pharmacology*; D004926:Escherichia coli / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008819:Mice, Nude / Q000276:immunology; D012822:Silicon Dioxide / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology; D013911:Thorium Dioxide / Q000494:pharmacology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D012822:Silicon Dioxide; D002351:Carrageenan; D013911:Thorium Dioxide