title: Functional opiate receptors in the guinea-pig ileum: their differentiation by means of selective tolerance development.
abstract: A differentiation of multiple opiate receptors in the electrically stimulated longitudinal muscle-myenteric plexus preparation of the guinea-pig ileum is described employing the technique of tolerance development of selective opiate receptors. Apparently, mu- and kappa-opiate receptors are clearly differentiated in this tissue, since highly tolerant mu-receptors (80-fold) coexist with kappa-receptors of almost normal sensitivity and vice versa. Attempts to demonstrate delta-receptors failed, as there was complete cross-tolerance between mu- and delta-agonists. It is proposed that delta-agonists bring about their action via mu-receptors in this preparation. Although mu- and kappa-receptors have been demonstrated, neither of them appear to represent a uniform population.
mesh_terms: D000818:Animals; D004361:Drug Tolerance; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009294:Narcotics / Q000494:pharmacology; D011957:Receptors, Opioid / Q000145:classification / Q000187:drug effects*
chemical_list: D009294:Narcotics; D011957:Receptors, Opioid