title: [Pharmacokinetics of ceftizoxim (author's transl)].
abstract: Ceftizoxim is a new cephalosporin derivative, which is also effective against anaerobic rods. The tolerability is excellent. Its pharmacokinetics after parenteral administration of 2 g were investigated in 12 healthy male volunteers. The half-life was 1.40 +/- 0.41 hours, the total clearance 194 l/min. The urinary excretion of the biological effective antibiotic amounted to 66.26 +/- 25.71%. These figures are in the same order of magnitude as those of older cephalosporins.
mesh_terms: D000328:Adult; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood; D015296:Ceftizoxime; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate
chemical_list: D015296:Ceftizoxime; D002439:Cefotaxime
vernacular_title: Pharmakokinetik von Ceftizoxim.