Modifications of membrane cholesterol content affects electrical properties and prolactin release of cultured pituitary cells.
Treatment of cloned pituitary cells (GH3/B6) with cholesterol-enriched liposomes, which presumably increases membrane cholesterol content, affects the passive and active electrophysiological properties and stimulates the release of prolactin (PRL).
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology*; D002784:Cholesterol / Q000494:pharmacology*; D002999:Clone Cells / Q000502:physiology; D007473:Ion Channels / Q000502:physiology; D008081:Liposomes / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D010902:Pituitary Gland / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats
D007473:Ion Channels; D008081:Liposomes; D011388:Prolactin; D002784:Cholesterol