title: Glucocorticoids and aspirin inhibit and cyproterone acetate enhances the androgenic response in mouse kidney.
abstract: Glucocorticoids and aspirin antagonize the androgenic response in mouse kidney, but not in ventral prostate or seminal vesicles. These agents impeded the testosterone-mediated increase in kidney weight, cytochrome c oxidase, and lysosomal hydrolases and urinary excretion of lysosomal hydrolases and proteins. They also attenuated the testosterone-induced decrease in enzyme latency and membrane stability of kidney lysosomes. In contrast, the antiandrogen cyproterone acetate is weakly androgenic in kidney and potentiates testosterone-induced lysosomal enzymuria and proteinuria (synandrogenic effect).
mesh_terms: D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D003907:Dexamethasone / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D006596:Hexosaminidases / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008247:Lysosomes / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D017373:Cyproterone Acetate; D003907:Dexamethasone; D003534:Cyproterone; D003576:Electron Transport Complex IV; D006596:Hexosaminidases; D005966:Glucuronidase; D001241:Aspirin