Intracerebroventricular administration of nanogram amounts of beta-endorphin and Met-enkephalin causes retrograde amnesia in rats.
The intracerebroventricular (icv) administration of 5.0 or 25.0 ng of beta-endorphin or Met-enkephalin causes retrograde amnesia for a shuttle avoidance task ion rats. In both cases, the higher dose was more effective than the lower one. The present results confirm previous similar findings obtained using systemic administrations of these compounds, and suggest that the amnestic effect of beta-endorphin and Met-enkephalin is mediated centrally.
D000647:Amnesia / Q000139:chemically induced*; D000648:Amnesia, Retrograde / Q000139:chemically induced*; D000818:Animals; D001362:Avoidance Learning; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000008:administration & dosage*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
D004723:Endorphins; D004745:Enkephalins; D004744:Enkephalin, Methionine; D001615:beta-Endorphin