title: Thymic humoral factor effect on intracellular lymphocyte cAMP in patients with ankylosing spondylitis.
abstract: Intracellular cAMP was measured in peripheral blood mononuclear cells from patients with ankylosing spondylitis and from controls. The effect of thymic humoral factor (THF) on T lymphocyte cAMP content was monitored in both groups to determine if there were any differences in immature T cell proportions. Equivalent cAMP levels were found in patients and controls in the absence of THF and again after stimulation with this immune modulator.
mesh_terms: D000328:Adult; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013935:Thymic Factor, Circulating / Q000008:administration & dosage*; D013951:Thymus Hormones / Q000008:administration & dosage*
chemical_list: D013951:Thymus Hormones; D013935:Thymic Factor, Circulating; D000242:Cyclic AMP