[Efficacy of protective effect of aminopropylamino-ethylthiophosphate in neutron beam, gamma or X-irradiation of mice (author's transl)].
The efficacy of the radioprotective agent aminopropylamino-ethylthiophosphate (WR 2721) was tested against different kinds of radiation on female NMRI-mice. The animals were divided into 4 groups and were exposed to neutrons as main component, to secondary gamma rays in a tissue-equivalent phantom, to pure gamma rays and to X-rays respectively. The following dose reduction factors have been obtained: 1.05 for neutron-irradiation, 1.33 for gamma irradiation in tissue-equivalent phantom, 1.69 for pure gamma rays and 2.08 for X-rays. The protective agent WR 2721 is apparently more efficient against low LET radiation. The mechanism of protection has been discussed in this respect.
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005720:Gamma Rays; D008433:Mathematics; D051379:Mice; D009502:Neutrons; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D014965:X-Rays
D009946:Organothiophosphorus Compounds; D004999:Amifostine
Schutzeffekt von Aminopropylamino-äthylthiophosphat (WR 2721) bei Neutronen-, Gamma- oder Röntgenbestrahlung von Mäusen.