title: Plasma digoxin concentrations during administration of dietary fibre (guar gum) in man.
abstract: The effect of guar gum on digoxin absorption was investigated in eleven healthy volunteers. The drug was administered in the morning during two five-day-periods, together with a liquid mixed test meal (+/- 18 g guar). By measuring plasma digoxin concentrations no differences were registered between the control and guar gum period. It is concluded that long-term administration of guar gum will not interfere with adequate digitalization (digoxin bioavailability).
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004043:Dietary Fiber; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male
chemical_list: D004043:Dietary Fiber; D004077:Digoxin