[Naloxone-dependent morphine-induced depression of the snail response to serotonin].
Morphine which was added to the extracellular solution in a concentration of 1.10(-5) M, rapidly and reversibly depressed depolarizing (15 cells of 20) and hyperpolarizing (6 cells of 12) serotonin (1.10(-6) M) responses of neurons of the mollusc Helix lucorum. The depressing morphine effect was antagonized by naloxone (1.10(-5) M). The results suggest involvement of an opiate receptor mechanism. Dose-response curves for serotonin before morphine application and in the presence of morphine show a noncompetitive mechanism of morphine-serotonin interaction.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006372:Helix, Snails; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009270:Naloxone / Q000008:administration & dosage*; D009474:Neurons / Q000032:analysis / Q000187:drug effects*; D011957:Receptors, Opioid / Q000032:analysis*; D012702:Serotonin Antagonists
D011957:Receptors, Opioid; D012702:Serotonin Antagonists; D009270:Naloxone; D009020:Morphine
Nalokson-zavisimoe snizhenie otvetov neĭronov ulitki na serotonin, vyzvannoe morfinom.