Poly(ADP-ribose) synthetase inhibitors enhance streptozotocin-induced killing of insulinoma cells by inhibiting the repair of DNA strand breaks.
D007516:Adenoma, Islet Cell / Q000188:drug therapy*; D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects*; D007340:Insulinoma / Q000188:drug therapy*; D007515:Islets of Langerhans / Q000201:enzymology; D008647:Mesocricetus; D009244:NAD+ Nucleosidase / Q000037:antagonists & inhibitors*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009536:Niacinamide / Q000494:pharmacology; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology*
D001549:Benzamides; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D009536:Niacinamide; D013311:Streptozocin; C025160:3-aminobenzamide; D009244:NAD+ Nucleosidase