Inhibition of herpes simplex virus replication by methyl daunosamine.
Methyl daunosamine inhibited the replication of herpes simplex virus type 1 in a dose-dependent manner. The growth of the host Vero cells was not affected by daunosamine levels that had significant antiviral activity (2.5 mM) but was inhibited by concentrations of 5 mM or greater. Methyl daunosamine appears to be unique among the sugars with antiviral activity because at antiviral concentrations it did not inhibit the glycosylation of macromolecules.
D000617:Aminoglycosides / Q000494:pharmacology*; D000998:Antiviral Agents; D002478:Cells, Cultured; D018139:Simplexvirus / Q000187:drug effects*; D013997:Time Factors; D014779:Virus Replication / Q000187:drug effects*
D000617:Aminoglycosides; D000998:Antiviral Agents; C035570:methyldaunosamine