title: Application of a chemically inactivated, adjuvanted vaccine to control abortigenic infection of mares by equine herpesvirus I.
abstract: A chemically inactivated, adjuvanted vaccine prepared from a virulent strain of Equine herpesvirus I (EHV-I) was used to immunize pregnant Thoroughbred broodmares during a five-year field test designed to determine its safety and efficacy. Each mare in the vaccinated groups received 3 intramuscular injections of vaccine beginning immediately prior to and during the last half of pregnancy. Vaccine was injected at approximately 60-day intervals. The accumulated incidence of EHV-I abortions among vaccinated mares during the field trial period was 1.6/1000 as compared with an incidence of 6.8/1000 in the remainder of the study population.
mesh_terms: D000034:Abortion, Veterinary / Q000517:prevention & control*; D000276:Adjuvants, Immunologic; D000818:Animals; D005260:Female; D006564:Herpesviridae / Q000276:immunology*; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000276:immunology*; D006734:Horse Diseases / Q000517:prevention & control*; D006736:Horses; D011247:Pregnancy; D014611:Vaccination; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D014613:Vaccines, Attenuated; D014765:Viral Vaccines