Inhibitory effect of fibronectin on the fibrin formation.
125I-fibronectin is incorporated into fibrin when blood plasma is clotted with thrombin. This process is dependent upon fibronectin concentration, temperature, and the presence of calcium ions. Fibronectin appears to be a very strong inhibitor of fibrin formation and influences both the thrombin clotting time and fibrin quality.
D001667:Binding, Competitive; D001777:Blood Coagulation / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology; D003864:Depression, Chemical; D005337:Fibrin / Q000096:biosynthesis* / Q000378:metabolism; D005353:Fibronectins / Q000494:pharmacology*; D006801:Humans; D011956:Receptors, Cell Surface; D017469:Receptors, Fibronectin; D013918:Thrombin Time
D005353:Fibronectins; D011956:Receptors, Cell Surface; D017469:Receptors, Fibronectin; D005337:Fibrin; D002118:Calcium