Location of the gene responsible for Rous sarcoma regression in the B-F region of the B complex (MHC) of the chicken.
We studied the fate of tumours induced by PR-RSV-C and B77-C in inbred chicken lines CB, CC and CB.R1. Rous sarcomas regressed in the CB and CB.R1 lines which are identical in the B-F region of the B complex. In contrast, progressive tumour growth was observed in the CC line which differed in the B-F region from the CB and CB.R1 lines and was identical in the B-G region with the CB.R1 line. These results suggest that the gene responsible for Rous sarcoma regression is located in the B-F region of the B complex.
D000818:Animals; D002645:Chickens / Q000235:genetics; D002874:Chromosome Mapping; D008285:Major Histocompatibility Complex; D009365:Neoplasm Regression, Spontaneous; D001357:Sarcoma, Avian / Q000235:genetics* / Q000276:immunology