title: A transient outward current in rat sympathetic neurones.
abstract: Voltage-clamped rat sympathetic neurones exhibited a transient outward current similar to that previously described in invertebrate neurones and marine egg cells. It had an activation threshold of about -60 mV and displayed both voltage and time-dependent inactivation. In current clamp, this current manifested as a pronounced outward rectification at the onset of electrotonic potentials, increasing the latency to directly-evoked action potentials. The amplitude of the current was dependent on the external K+ concentration and was reduced by 4-aminopyridine.
mesh_terms: D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005728:Ganglia, Sympathetic / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology; D008564:Membrane Potentials; D009474:Neurons / Q000502:physiology; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D009435:Synaptic Transmission
chemical_list: D007473:Ion Channels; D011188:Potassium