title: Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.
abstract: Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression.
mesh_terms: D000818:Animals; D001483:Base Sequence; D002116:Calcitonin / Q000235:genetics*; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D005786:Gene Expression Regulation; D005796:Genes; D007031:Hypothalamus / Q000378:metabolism; D008954:Models, Biological; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D012326:RNA Splicing; D012332:RNA, Heterogeneous Nuclear / Q000032:analysis; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism
chemical_list: D012332:RNA, Heterogeneous Nuclear; D012333:RNA, Messenger; D002116:Calcitonin; D004247:DNA; D004262:DNA Restriction Enzymes