Hair follicle discrimination dysfunction in multiple sclerosis patients.
A method was developed of assessing somatosensory deficits quantitatively using hair follicle displacement as a stimulus within a psychophysical signal detection task paradigm. Multiple sclerosis patients with and without somatosensory disturbances could be differentiated and compared with normal subjects. This method may distinguish patients with somatosensory dysfunction, and dorsal funiculus neuropathology may underlie this distinction.
D000328:Adult; D004193:Discrimination Learning / Q000502:physiology*; D005073:Evoked Potentials, Somatosensory; D006197:Hair / Q000502:physiology*; D006801:Humans; D008297:Male; D008465:Mechanoreceptors / Q000503:physiopathology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D010812:Physical Stimulation / Q000295:instrumentation; D012684:Sensory Thresholds; D013003:Somatosensory Cortex / Q000503:physiopathology; D013116:Spinal Cord / Q000503:physiopathology; D009435:Synaptic Transmission; D014110:Touch / Q000502:physiology