[Immunological detection of sphingomyelin exchange protein in tumors and in embryonic rat liver].
The interaction of postmicrosomal supernatants from the Jensen sarcoma, sarcoma 45, nephroma RA, normal, regeherating and fetal rat livers with antisera to the sphingomyelin exchange protein isolated from hepatoma 27 was studied by double immunodiffusion. It was shown that this protein is present in comparable amounts in all the tumours tested and in fetal rat liver, whereas in normal and regenerating liver its content is negligible. Based on the correlation between the content of sphingomyelin exchange protein in cell cytosols and the amount of sphingomyelin in the corresponding mitochondria it is suggested that this protein is responsible for the presence of sphingomyelin in mitochondria.
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D005260:Female; D005333:Fetus; D005779:Immunodiffusion; D007680:Kidney Neoplasms / Q000378:metabolism*; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008115:Liver Regeneration; D008928:Mitochondria / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D009363:Neoplasm Proteins / Q000032:analysis*; D009374:Neoplasms, Experimental / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013109:Sphingomyelins / Q000032:analysis; D009396:Wilms Tumor / Q000378:metabolism*
D009363:Neoplasm Proteins; D013109:Sphingomyelins
Immunologicheskoe obnaruzhenie sfingomielinperenosiashchego belka v opukholiakh i embrional'noĭ pecheni krys.