Abnormal proliferation of intraergastoplasmic microfilaments in myelinated schwann cells: ultrastructural study of two cases.
We report the ultrastructural findings in superficial peroneal nerve biopsies in two patients, one with idiopathic sensory neuropathy and the other with the Guillain-Barré syndrome and Hodgkin's disease. In addition to demyelination, there was an intense proliferation of microfilaments within numerous vesicles of the endoplasmic reticulum of a great number of myelinated Schwann cells. This abnormality does not appear to have been previously reported in the literature. The mechanisms responsible for this finding are unknown.
D000368:Aged; D001706:Biopsy; D003599:Cytoskeleton / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000648:ultrastructure*; D010523:Peripheral Nervous System Diseases / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000473:pathology; D012583:Schwann Cells / Q000648:ultrastructure*