A mouse model of transmural myocardial necrosis due to coxsackievirus B4: observations over 12 months.
The course of coxsackievirus B4 necrotizing myocarditis was studied over a 12-month period in 712 ICR Swiss mice inoculated at less than 48 h of age. Affected animals were sacrificed at intervals until 1 year. Microscopically, focal myocardial necrosis, which was often transmural in extent with mixed inflammatory exudate, and subsequent fibrous replacement were induced in 75% of the examined animals. The left ventricle (63 of 69 subjects, 91.3%), interventricular septum (39 of 69 subjects, 56.5%) and right ventricle (26 of 69 subjects, 37.7%) were most frequently involved. Thinning of the ventricular wall and grossly apparent localized ventricular bulges (aneurysms) were seen in 22 subjects (the left ventricle 16 times, the right ventricle 5 times, and the interventricular septum 5 times). Coronary arteries were normal in all instances.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D004195:Disease Models, Animal; D029822:Enterovirus B, Human / Q000276:immunology / Q000472:pathogenicity*; D051379:Mice; D009205:Myocarditis / Q000382:microbiology* / Q000473:pathology; D009336:Necrosis; D013997:Time Factors
D000956:Antigens, Viral