Consistent appearance of microtubules in cells productively infected with various strains of type 2 herpes simplex virus.
Electron microscopic examination showed microtubular structures in FL cells infected with all 18 strains of HSV-2 examined, but not in cells infected with 9 strains of HSV-1. These structures were also detected in other cultured cells (Vero and Earle's L cells) infected with HSV-2, and also in vivo in cells, such as neuronal cells of the spinal ganglia and liver cells, of one-day-old suckling mice (DDD strain) infected with this type of virus. Thus the microtubules were consistently detected in cells productively infected with HSV-2. No other herpesviruses so far examined produced microtubular structures such as those observed in HSV-2 infected cells.
D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D006561:Herpes Simplex / Q000473:pathology*; D006564:Herpesviridae / Q000254:growth & development; D007739:L Cells; D051379:Mice; D008870:Microtubules / Q000648:ultrastructure*; D018139:Simplexvirus / Q000254:growth & development*