Failure to find electrophysiological correlates of chronic neuroleptic-induced oral dyskinesias in cats: somatosensory and substantia nigra evoked potentials, electroencephalogram, and caudate spindles.
Each of nine cats was prepared with 30 chronically implanted stainless steel gross electrodes in cortex, basal ganglia and other brain structures. Measurements were taken for 0.5-11.5 months of baseline, chronic daily administration of chlorpromazine, and withdrawal. In most cases there was also a second cycle of drug administration and withdrawal. Although we observed dramatic, persistent increases in licking behavior, suggestive of tardive dyskinesia, consistent correlated patterns were not observed in somatosensory or substantia nigra evoked potentials, electroencephalogram, or spindling evoked in cortex by caudate stimulation.
D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D006801:Humans; D008409:Mastication / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D013378:Substantia Nigra / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D002746:Chlorpromazine