Familial pyrophosphate arthropathy. Occurrence and Crystal Identification.
Hereditary pyrophosphate arthropathy has been observed in three Swedish families and in a few other caucasian populations. The inheritance is most probably autosomal dominant with a variable penetrance. The most severe cases have been found in homozygotes among isolates of immigrants in Slovakia and Chile. Studies on genetic and etio-pathogenetic factors in hereditary pyrophosphate arthropathy, and the utilization of new diagnostic techniques for crystal identification, are important approaches towards a further understanding of the disease.
D000328:Adult; D002805:Chondrocalcinosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D011756:Diphosphates / Q000032:analysis*; D005006:Ethnicity; D005260:Female; D005799:Genes, Dominant; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged
D011756:Diphosphates