Interaction of neurotensin, cholecystokinin, and secretin in the stimulation of the exocrine pancreas in the dog.
The effects of exogenous neurotensin, secretin, and cholecystokinin-33 alone and in combination on pancreatic secretion were investigated in dogs prepared with pancreatic fistulae. Neurotensin infused intravenously caused a dose-dependent stimulation of exocrine pancreatic secretion. Increasing doses of neurotensin combined with a constant small dose of secretin potentiated pancreatic output of protein and had a tendency to reduce secretion of the bicarbonate. Increasing doses of neurotensin combined with a constant small dose of cholecystokinin-33 potentiated pancreatic output of bicarbonate and lead to a reduction (insignificant) of pancreatic protein secretion. These observations suggest an interaction of neurotensin with pancreatic receptors for secretin and cholecystokinin.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002766:Cholecystokinin / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D009496:Neurotensin / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects; D011949:Receptors, Cholecystokinin; D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone; D012633:Secretin / Q000494:pharmacology*; D013268:Stimulation, Chemical
D001639:Bicarbonates; D011956:Receptors, Cell Surface; D011949:Receptors, Cholecystokinin; D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone; C029937:secretin receptor; D012633:Secretin; D009496:Neurotensin; D002766:Cholecystokinin