[Morphology of thrombolysis as affected by a plasmakinase preparation].
The effect of a new thrombolytic preparation, plasmakinase, on experimental coagulates and thrombi was studied morphologically. Histological and electron microscopic studies revealed changes in the structure of fibrin fibers in the form of separation of fibers into individual protofibrils and subsequent degradation into globular particles. There were disorders in the fibrin association with blood cells, washing out of partially hemolyzed red blood cells into the bloodstream, decrease in the size of thrombi and restoration of the vessel lumen.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D010770:Phosphotransferases / Q000097:blood / Q000627:therapeutic use*; D010960:Plasminogen Activators / Q000097:blood / Q000627:therapeutic use*; D051381:Rats; D013916:Thrombelastography; D013927:Thrombosis / Q000188:drug therapy / Q000473:pathology*; D013997:Time Factors
D005340:Fibrinogen; D010770:Phosphotransferases; D010447:Peptide Hydrolases; C035188:plasmakinase; D010960:Plasminogen Activators
Morfologiia lizisa tromba pod deĭstviem preparata plazmakinazy.