Adenovirus-related RNA sequences in human neurogenic tumours.
Thirty two human tumours, mainly neurogenic, have been investigated for the presence of adenovirus-related RNA sequences. 3H-labelled tumour virus DNA probes derived from human adenoviruses types 2 and 12, bovine adenovirus type 3, and avian adenovirus CELO were hybridized in-situ on tumour kryostat sections under conditions that detect complementary RNA. Tumour virus-related RNA was detected in 62% of all tumours tested, but was not detectable in normal human brain tissues. Expression of tumour virus-related RNA was found in 2/4 astrocytomas, 2/4 metastatic brain carcinomas, 2/2 glioblastomas, 1/1 melanoma, 5/7 meningiomas, 4/4 neurinomas, 1/2 oligodendrogliomas, and 1/1 rhabdomyosarcoma. The presence of adenovirus-related RNA in the majority of human neurogenic tumours may reflect a viral involvement in the pathogenesis of these tumours.
D000256:Adenoviridae; D000260:Adenoviruses, Human; D001254:Astrocytoma / Q000032:analysis; D000259:Aviadenovirus; D001932:Brain Neoplasms / Q000032:analysis*; D005910:Glioma / Q000032:analysis; D006801:Humans; D008545:Melanoma / Q000032:analysis; D008577:Meningeal Neoplasms / Q000032:analysis; D008579:Meningioma / Q000032:analysis; D009442:Neurilemmoma / Q000032:analysis; D009693:Nucleic Acid Hybridization; D009837:Oligodendroglioma / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis*; D012208:Rhabdomyosarcoma / Q000032:analysis
D012367:RNA, Viral