title: The effects of vitamin E on the indicator enzymes of organella membranes in the injured liver.
abstract: Acute and chronic liver damage was caused by the administration of either galactosamine or carbon tetrachloride. Consequently, the rats with damaged livers were killed after vitamin E was administered. The livers were removed and were homogenated. Indicator enzymes (5'-nucleotidase, arylsulfatase, cytochrome C oxidase and glucose-6-phosphatase) of organella membranes were measured in the homogenates of the normal and damaged livers. The effects of vitamin E resulted in the stabilizing of the impaired membranes of plasma, lysosome, mitochondria and microsome; (1) the abnormal decrease of 5'-nucleotidase activity and glucose-6-phosphatase activity, and the abnormal increase of arylsulfatase activity, which induced galactosamine or carbon tetrachloride, and (2) the abnormal decrease of cytochrome C oxidase activity induced by galactosamine- HCl, were normalized.
mesh_terms: D015720:5'-Nucleotidase; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007425:Intracellular Membranes / Q000201:enzymology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology; D008297:Male; D009708:Nucleotidases / Q000378:metabolism; D009940:Organoids / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D014810:Vitamin E; D003576:Electron Transport Complex IV; D009708:Nucleotidases; D015720:5'-Nucleotidase; D005952:Glucose-6-Phosphatase; D001192:Arylsulfatases