Synthetic corticotropin-releasing factor stimulates secretion of immunoreactive beta-endorphin/beta-lipotropin and ACTH by human fetal pituitaries in vitro.
Synthetic ovine CRF, in an amount approximating that found in pituitary portal plasma of the rat, induced a significant increase in the secretion of both ACTH and immunoreactive beta-endorphin/beta-LPH (i beta-END/LPH) by human fetal hemipituitaries in an in vitro superfusion system. This finding suggests that a molecule similar to synthetic ovine CRF may be a physiologic hypothalamic releasing factor in man.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004723:Endorphins / Q000378:metabolism*; D005260:Female; D005333:Fetus; D006801:Humans; D007700:Kinetics; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000196:embryology / Q000378:metabolism*; D011247:Pregnancy; D012756:Sheep; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000378:metabolism*
D004723:Endorphins; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D008083:beta-Lipotropin