Gold suppression of human neutrophil function in vitro.
The effect of myochrysine and Auranofin on leukocyte function were measured using quantitative leukocyte iodination. Both suppressed iodination at concentrations achieved in patients. Under conditions of leukocyte submaximum stimulation, enhanced gold suppression was observed. The active portion of Myochrysine appeared to be protein bound while the active portion of Auranofin appeared to be free. Preincubation experiments indicated suppression of the myeloperoxidase-halide system. Inhibition of this probable mediator of inflammation may be one of the modes of action of gold.
D006046:Gold / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007455:Iodine / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009195:Peroxidase / Q000037:antagonists & inhibitors; D011485:Protein Binding
D006046:Gold; D007455:Iodine; D009195:Peroxidase