title: Evidence for bursal involvement in the pathogenesis of hemorrhagic enteritis of turkeys.
abstract: The pathogenesis of hemorrhagic enteritis in turkey poults infected with hemorrhagic enteritis virus (HEV) at 3 days or at 2 or 5 weeks of age was compared with pathogenesis in poults that had been chemically bursectomized neonatally and exposed to cell-culture-propagated virus at 2 or 5 weeks of age. Conventional poults exposed to HEV at 2 or 5 weeks developed clinical disease, and mortality ranged from 38% to 100%. In addition to the splenic and intestinal lesions usually seen with HEV infection, the pancreas, bursa of Fabricius, and thymus were also affected. In contrast, although they were free from detectable maternal antibody, poults infected with HEV at 3 days of age failed to develop clinical disease or mortality; however, virus was demonstrated by histological and electron microscopic examinations in spleens of these poults. Neonatal chemical bursectomy completely prevented the clinical signs, gross lesions, and mortality induced by HEV in poults at 2 or 5 weeks of age. These findings strongly suggest that an intact bursa is necessary for HEV to induce disease in turkeys.
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius / Q000187:drug effects / Q000502:physiology*; D003332:Coronaviridae / Q000472:pathogenicity*; D004752:Coronavirus, Turkey / Q000472:pathogenicity*; D003520:Cyclophosphamide / Q000494:pharmacology; D004753:Enteritis, Transmissible, of Turkeys / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000662:veterinary*; D013154:Spleen / Q000473:pathology; D014422:Turkeys
chemical_list: D003520:Cyclophosphamide