[Malignant transformation of newborn hamster cells by herpes simplex virus type 2].
The oncogenic potentials of HSV-2 inactivated by ultraviolet rays in newborn hamster cell culture were studied. Virus-induced morphological and malignant transformation of cells was accompanied by synthesis of virus-specific antigen, changes in morphology, formation of colonies in semi-liquid agar, and tumorigenicity of cells. The animals bearing tumors induced by transformed cells showed humoral and cellular immune responses to the virus-specific antigen. Lines of transformed and tumor cells were obtained and established in passages.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D006224:Cricetinae; D018139:Simplexvirus / Q000276:immunology / Q000472:pathogenicity*; D013997:Time Factors; D014412:Tumor Virus Infections / Q000276:immunology; D014776:Virus Cultivation
D000914:Antibodies, Viral; D000956:Antigens, Viral
Zlokachestvennaia transformatsiia kletok novorozhdennykh khomiakov virusom prostogo gerpesa tipa 2.