title: Organization of chicken DNA sequences homologous to the transforming gene of avian myeloblastosis virus. I. Restriction enzyme analysis of total DNA from normal and leukemic cells.
abstract: Hybridization probes consisting of cloned DNA recombinants which represent different regions of the leukemogenic sequence (amv) from avian myeloblastosis virus were used to carry out a more detailed restriction endonuclease analysis of the homologous sequences (proto-amv) present in normal and leukemic chicken DNA. The results show that four large introns interrupt the normal cellular proto-amv sequences and that there is no major rearrangement of these sequences in leukemic myeloblasts.
mesh_terms: D000818:Animals; D001353:Avian Leukosis / Q000235:genetics*; D001354:Avian Leukosis Virus / Q000235:genetics*; D009189:Avian Myeloblastosis Virus / Q000235:genetics*; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002645:Chickens / Q000235:genetics*; D004247:DNA; D004262:DNA Restriction Enzymes; D005814:Genes, Viral; D009693:Nucleic Acid Hybridization; D009857:Oncogenes
chemical_list: D004247:DNA; D004262:DNA Restriction Enzymes