Effect of neuraminidase on luteinizing hormone/chorionic gonadotrophin binding to the ovarian and testicular membranes from different mammalian species.
After treatment of the ovarian and testicular membranes from several mammalian species an elevation in the specific binding of human [125I]-labelled CG could be observed. With the assumption that this effect is due to sialic acid-masked receptors, the presence of such receptors seem to be a common property of most mammalian gonads. An interesting observation was the abnormally high hormone binding capacity of the Syrian hamster ovary, as compared to other hamster species, and the lack of a neuraminidase effect in the ovary of the Syrian hamster.
D000818:Animals; D002415:Cats; D002417:Cattle; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D006224:Cricetinae; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D051379:Mice; D009439:Neuraminidase / Q000494:pharmacology*; D010053:Ovary / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D011974:Receptors, LH; D012756:Sheep; D013045:Species Specificity; D013552:Swine; D013737:Testis / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D011956:Receptors, Cell Surface; D011974:Receptors, LH; D007986:Luteinizing Hormone; D009439:Neuraminidase