title: Low LH (hCG) receptor concentration in ovarian follicles in endometriosis.
abstract: The concentration of LH (hCG) receptors in the granulosa cells of ovarian follicles was assayed in 20 patients with histologically proven endometriosis and in 6 control patients. The levels of receptors in 15 patients with ovarian endometriosis (0.48 +/- 0.46 fmol/mg protein) and in 5 patients with endometriosis without ovarian involvement (0.51 +/- 0.52 fmol/mg protein) were lower (p less than 0.01 and p less than 0.05, respectively) than in control patients (1.32 less than 0.61 fmol/mg protein). The severity of the disease was not reflected in the results. The low receptor concentration in endometriosis suggests a failure in the mechanism mediating LH action in the follicle.
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000032:analysis; D008875:Middle Aged; D006080:Ovarian Follicle / Q000032:analysis*; D011956:Receptors, Cell Surface / Q000032:analysis*; D011974:Receptors, LH
chemical_list: D006063:Chorionic Gonadotropin; D011956:Receptors, Cell Surface; D011974:Receptors, LH; D007986:Luteinizing Hormone