The hemostatic effect of conjugated water-soluble estrogens in rats.
Estrogenic steroids have been used as hemostatic agents in various surgical procedures in humans. Their use to reduce bleeding has been based mainly on clinical observation. The present study was carried out to test experimentally whether intravenously administered Premarin reduces capillary bleeding. Skin-graft donor sites in rats served as the standard capillary bleeding source in this controlled double-blind experiment, in which Premarin was found to appreciably reduce capillary bleeding.
D000818:Animals; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D006490:Hemostatics / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D016038:Skin Transplantation
D004966:Estrogens, Conjugated (USP); D006490:Hemostatics