[Sensitivity of hypothalamic neurons to beta-endomorphin, met-enkephalin, and thyroliberin].
A study was made of susceptibility of hypothalamic neurons to beta-endorphine, thyroliberin and met-enkephalin applied microiontophoretically. The opioids were shown to exert a primarily unidirectional effect on the same neurons irrespective of the fact that the inhibitory action of beta-endorphine was more pronounced. The nalorphine-competitive antagonist of the opiates removed the met-enkephalin-induced inhibition. Unlike opioids, thyroliberin largely activated the test neurons. The possibility of neuropeptide participation in the control of gonadotropic function of the pituitary is discussed.
D000818:Animals; D003864:Depression, Chemical; D004594:Electrophysiology; D004723:Endorphins / Q000494:pharmacology / Q000502:physiology*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology / Q000502:physiology*; D001615:beta-Endorphin
D004723:Endorphins; D004745:Enkephalins; D009270:Naloxone; D004744:Enkephalin, Methionine; D013973:Thyrotropin-Releasing Hormone; D001615:beta-Endorphin
Chuvstvitel'nost' neĭronov gipotalamicheskikh struktur k beta-éndomorfinu, met-énkefalinu, tiroliberinu.