Role of beta-adrenergic receptors in the antidepressant activity of alprazolam.
Chronic intravenous infusion of reserpine significantly increased beta-adrenergic receptors (beta-AR) in the cerebra cortex of rats. This increase in beta-AR is partially blocked by chronic treatment with alprazolam. However, similar effects were not observed with diazepam. These results indicate that beta-AR may be involved in the antidepressant activity of alprazolam.
D000525:Alprazolam; D000818:Animals; D000928:Antidepressive Agents; D001569:Benzodiazepines / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004082:Dihydroalprenolol; D005260:Female; D051381:Rats; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D012110:Reserpine / Q000494:pharmacology
D000928:Antidepressive Agents; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D001569:Benzodiazepines; D004082:Dihydroalprenolol; D012110:Reserpine; D003975:Diazepam; D000525:Alprazolam