Subcellular binding of 99Tcm-gluconate in infarcted myocardium in dogs.
Binding of 99Tcm-gluconate on the subcellular level in myocardial infarct tissue in the dog was investigated by means of a fractionated centrifugation technique. High isotope activity/g protein was recorded in the mitochondrial fraction indicating the 99Tcm-gluconate binds preferentially to a protein structure localized in the mitochondria.
D000818:Animals; D002458:Cell Fractionation; D004285:Dogs; D005942:Gluconates / Q000008:administration & dosage / Q000378:metabolism*; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008929:Mitochondria, Heart / Q000032:analysis / Q000378:metabolism*; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000032:analysis / Q000378:metabolism*; D015609:Organotechnetium Compounds; D011190:Potassium Cyanide / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats; D013667:Technetium / Q000008:administration & dosage / Q000378:metabolism*
D005942:Gluconates; D015609:Organotechnetium Compounds; C032080:technetium Tc 99m gluconate; D013667:Technetium; D011190:Potassium Cyanide