[Effect of benzimidazole derivatives and levamisole (phenylimidothiazole) on cyclic 3':5'-AMP phosphodiesterase from pig brain].
The effects of phenylimidothiazole and some benzimidazole derivatives on phosphodiesterase of cyclic 3':5'-AMP (cAMP) from pig brain were studied. Depending on their concentrations the compounds tested activated or inhibited the enzyme activity. A correlation between the effects of benzimidazoles and phenylimidothiazole which is known to exert an immunomodulating action was observed.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D007700:Kinetics; D007978:Levamisole / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013552:Swine
D001562:Benzimidazoles; D007978:Levamisole; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Deĭstvie proizvodnykh benzimidazola i levamizola (fenilimidotiazola) na fosfodiésterazu tsiklicheskogo 3':5'-AMP iz mozga svin'i.