Na+/K+ ATPase and cell growth: effect of epidermal growth factor on the enzymatic activity in chick embryo epidermis during the embryonal development.
1. The behaviour of ATPase activity during embryonic development of chick embryo epidermis has been studied in the absence or presence of a single inoculation of EGF at the fifth day from fertilization (0-day). 2. EGF strongly decreases ATPase activity by affecting Na+/K+ ATPase. This effect occurs only if begun at 0-day. 3. This effect is due to the EGF induced decrease of -SH groups that are active part of Na+/K+ ATPase.
D000818:Animals; D002642:Chick Embryo; D000078404:Epidermal Cells; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004817:Epidermis / Q000196:embryology / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism
D013438:Sulfhydryl Compounds; D004815:Epidermal Growth Factor; D000254:Sodium-Potassium-Exchanging ATPase