[Multiple opiate receptor sites in the rabbit thalamus and cerebellum: preliminary characterization (author's transl)].
Inhibition of 3H-etorphine binding by D-Ala2, D-Leu5-enkephalin, a delta agonist and by morphiceptin, a mu agonist, reveals the existence of at least two classes of binding sites for the tritiated oviparine in membranes from the Rabbit thalamus and cerebellum. In the thalamus, approximately 50% of these sites appear to be mu receptor sites whereas the other half is neither of the mu nor of the delta subtype. In the cerebellum, at least 80% of the 3H-etorphine binding sites would belong to the mu subtype. This result may be related to the fact that the rabbit cerebellum contains appreciable quantities of methionine-enkephalin but little if any leucine-enkephalin.
D000818:Animals; D001667:Binding, Competitive; D002531:Cerebellum / Q000378:metabolism*; D005048:Etorphine / Q000378:metabolism; D007700:Kinetics; D009928:Organ Specificity; D011817:Rabbits; D011957:Receptors, Opioid / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013788:Thalamus / Q000378:metabolism*
D011957:Receptors, Opioid; D005048:Etorphine
Hétérogénéité comparée des sites récepteurs des opiacés dans le thalamus et dans le cervelet de Lapin: résultats préliminaires.