Acute membrane responses to viral action.
The effects of Sendai, a paramyxovirus, on the functional activity of 3 cell types, have been studied in vitro to establish whether a virus alone can cause pathophysiological changes. Neuronal cells are depolarized and suffer a loss of excitability which was attributed to an increase in membrane conductance. Spontaneously beating cardiac cells initially stop beating and then beat more rapidly and asynchronously. Anterior pituitary cells release hormones. In all 3 cases the effects are transient and the cells recover completely.
D000200:Action Potentials; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004553:Electric Conductivity; D005071:Evoked Potentials; D005727:Ganglia, Spinal / Q000382:microbiology* / Q000503:physiopathology; D006321:Heart / Q000382:microbiology* / Q000503:physiopathology; D009474:Neurons / Q000382:microbiology / Q000502:physiology*; D009976:Orthomyxoviridae Infections / Q000503:physiopathology*; D010222:Parainfluenza Virus 1, Human / Q000472:pathogenicity*; D010903:Pituitary Gland, Anterior / Q000382:microbiology* / Q000503:physiopathology; D051381:Rats