The effect of autonomic drugs on ureteric peristalsis: a canine in vivo study.
An in vivo canine model was developed in which the renal pelvis was perfused by a cannula nephrostomy and ureteric activity assessed by monitoring bolus volume and interperistaltic interval. The effect of autonomic drugs showed that the ureter contained alpha-adrenergic receptors which on stimulation caused an increase in ureteric contraction rate and a decrease in bolus volume. With beta-adrenergic receptor stimulation, there was complete inhibition of ureteric peristalsis for a variable period and evidence is presented that the beta-adrenergic receptors may be beta 1 rather than beta 2. Cholinergic stimulation of ureteric rate was observed, but seemed to be mediated indirectly via alpha-adrenergic receptors. No significant change was seen in ureteric activity with adrenergic blocking agents alone, suggesting that the physiological importance of these receptors in normal activity is questionable.
D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D014513:Ureter / Q000187:drug effects* / Q000502:physiology; D014563:Urodynamics / Q000187:drug effects*
D001337:Autonomic Agents; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta