Epstein-Barr virus (EBV)-induced lymphoproliferative disease in cotton-topped marmosets.
Six cotton-topped marmoset monkeys (Sangiunus oedipus) were inoculated with 10(5) transforming units of B95-8 virus, and two of them developed fatal lymphoproliferative disease. The EBV-carrying tumor cells from these marmosets had the following characteristics: (1) they were polyclonal by surface immunoglobulin and immunoglobulin production in vitro; (2) they had no specific chromosome abnormalities, and (3) they failed to form colonies in large percentages in agarose. It is proposed that a spectrum of phenotypes of EBV-induced lymphoproliferative diseases in the cotton-topped marmosets may be identified and are more akin to fatal infectious mononucleosis or X-linked lymphoproliferative syndrome than to Burkitt's lymphoma.
D000818:Animals; D002472:Cell Transformation, Viral; D002875:Chromosomes / Q000032:analysis; D002999:Clone Cells; D004854:Herpesvirus 4, Human / Q000276:immunology*; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000382:microbiology*; D010641:Phenotype; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D012452:Saguinus
D011947:Receptors, Antigen, B-Cell