Enhanced tumor growth in vivo by a factor in human platelets and rat liver.
Liver cell supernatant and platelet extract can promote the in vivo growth of herpes simplex virus type 2-transformed hamster embryo fibroblast cells. Delineation of necessary growth factors for tumor cells in vivo may open up new strategies to inhibit malignant cell growth.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006224:Cricetinae; D004622:Embryo, Mammalian; D005347:Fibroblasts; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000502:physiology*; D051381:Rats; D018139:Simplexvirus / Q000235:genetics*; D014020:Tissue Extracts / Q000494:pharmacology
D006133:Growth Substances; D014020:Tissue Extracts