Interaction of the benzodiazepine antagonists, CGS 8216 and Ro 15-1788, with central adenosine A-1 receptors.
Although the potent benzodiazepine antagonist CGS 8216 has in vitro activity indicative of an interaction with central adenosine systems, neither it, nor the benzodiazepine antagonist Ro 15-1788 showed any great degree of interaction with central adenosine A-1 receptors as measured by radioligand binding. It is concluded that interaction of benzodiazepine antagonists with A-1 receptors is not a property related to their antagonist activity.
D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism; D000818:Animals; D001569:Benzodiazepines / Q000037:antagonists & inhibitors*; D001570:Benzodiazepinones / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005442:Flumazenil; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011983:Receptors, Purinergic
D001570:Benzodiazepinones; D011720:Pyrazoles; D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D001569:Benzodiazepines; C027513:N(6)-cyclohexyladenosine; D005442:Flumazenil; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; D000241:Adenosine