title: Involvement of cyclic AMP and its receptor protein in filamentation of an Escherichia coli fic mutant.
abstract: Cyclic AMP (cAMP) inhibited septum formation in Escherichia coli PA3092 and induced cell filamentation at elevated temperatures. This phenomenon was first observed in E. coli PA3092 and is due to a temperature-sensitive mutation. We tentatively named this mutation fic (filamentation induced by cAMP). The fic gene was located near rpsL (formerly strA) on the E. coli K-12 map. the inhibitory effect of cAMP on cell division and filamentation in a fic mutant was not observed in a crp mutant. When cAMP was removed from the culture medium, filaments were divided into rods as the intracellular cAMP level decreased. These results suggest that the cAMP-cAMP receptor protein complex causes filamentation in the fic mutant, E. coli PA3092.
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D000242:Cyclic AMP / Q000502:physiology*; D004926:Escherichia coli / Q000166:cytology* / Q000235:genetics / Q000254:growth & development; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial; D009154:Mutation; D011953:Receptors, Cyclic AMP / Q000502:physiology*; D000091243:Ribosomal Protein S9; D013696:Temperature
chemical_list: D029968:Escherichia coli Proteins; D011953:Receptors, Cyclic AMP; D000091243:Ribosomal Protein S9; C000717190:RpsI protein, E coli; D000242:Cyclic AMP