Coronary vasoconstriction induced by leukotrienes in the anaesthetized dog.
In the anaesthetized dog LTC4, LTD4 (0.3-10 micrograms, injected into the coronary artery) and the thromboxane-mimetic U46619 (5-10 micrograms) decreased coronary blood flow. LTE4 (1-10 micrograms), however, did not affect coronary blood flow. The vasoconstrictor responses to LTC4, LTD4 or U46619 were not altered by the cyclo-oxygenase inhibitor indomethacin (5 mg/kg i.v.). LTC4 and LTD4 did not stimulate the release of any prostaglandin-like substance into the pericardial fluid. It is concluded that LTC4 and LTD4 are able to produce coronary vasoconstriction in vivo independent of the production of any cyclo-oxygenase metabolites of arachidonic acid.
D000758:Anesthesia; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D003331:Coronary Vessels / Q000187:drug effects*; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D017999:Leukotriene E4; D008297:Male; D013189:SRS-A / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014662:Vasoconstrictor Agents
D001095:Arachidonic Acids; D013189:SRS-A; D014662:Vasoconstrictor Agents; D016718:Arachidonic Acid; D017999:Leukotriene E4; D011464:Epoprostenol; D007213:Indomethacin