Cholera and cell regulation.
The cholera vibrio, unlike most pathogens, neither invades the body's cells nor causes them direct physical damage and thus does not engender inflammation or fever. Rather, the organism attaches itself to the intestinal epithelium, where it secretes a toxin that deranges cellular function. Study of the toxin's structure and mechanism of action is helping to elucidate normal enzymatic processes.
D000262:Adenylyl Cyclases / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism; D002771:Cholera / Q000276:immunology*; D002772:Cholera Toxin / Q000378:metabolism / Q000494:pharmacology*; D000242:Cyclic AMP / Q000096:biosynthesis; D003681:Dehydration / Q000139:chemically induced; D004848:Epithelium / Q000187:drug effects; D004926:Escherichia coli / Q000276:immunology; D005732:Gangliosides / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D009243:NAD / Q000378:metabolism; D013329:Structure-Activity Relationship; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced
D001427:Bacterial Toxins; D005732:Gangliosides; D009243:NAD; D006160:Guanosine Triphosphate; D002772:Cholera Toxin; D000242:Cyclic AMP; D000262:Adenylyl Cyclases