Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment.
The pathogenesis of infection of mice by the mammalian reoviruses involves several discrete steps. Each of the three viral outer capsid proteins has a highly distinct and specialized role: one protein (sigma 1) binds to cell surface receptors; a second protein (mu 1C) determines the capacity for viral growth at mucosal surfaces; and the third protein (sigma 3) is responsible for inhibiting cell macromolecular synthesis. A detailed picture of the molecular basis of reovirus virulence and attention is now emerging.
D000818:Animals; D005814:Genes, Viral; D006388:Hemagglutinins; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D010455:Peptides / Q000235:genetics; D012087:Reoviridae / Q000235:genetics* / Q000472:pathogenicity; D012088:Reoviridae Infections / Q000382:microbiology* / Q000517:prevention & control / Q000628:therapy; D013696:Temperature; D014764:Viral Proteins / Q000235:genetics
D006388:Hemagglutinins; D010455:Peptides; D014764:Viral Proteins