[Molecular mechanisms of stabilization and preparation of metabolic breaks in DNA strands in vivo. I. Tandem action of exonuclease V and DNA polymerase II].
Investigation of the formation of metabolic imbalance breaks in the DNA of thy- cells of E. coli during thymine starvation is described. The results of experiments indicate that two enzymes--exonuclease V and 3' exonuclease activity of DNA polymerase II take part in the formation of metabolic imbalance gaps. The manifestation of activity of the enzymes has a tandem character.
D004257:DNA Polymerase II / Q000378:metabolism*; D004269:DNA, Bacterial; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism*; D004355:Drug Stability; D004926:Escherichia coli / Q000201:enzymology*; D043211:Exodeoxyribonuclease V; D005092:Exonucleases / Q000378:metabolism*; D007700:Kinetics; D009154:Mutation
D004269:DNA, Bacterial; D004257:DNA Polymerase II; D004259:DNA-Directed DNA Polymerase; D003851:Deoxyribonucleases; D005092:Exonucleases; D043211:Exodeoxyribonuclease V
Molekuliarnye mekhanizmy stabilizatsii i reparatsii metabolicheskikh razryvov v tsepieakh DNK in vivo. I. Tandemnoe deĭstvie ékzonukleazy V i DNK-polimerazy II.