[Effect of memantine on membrane properties and postsynaptic potentials in neurons of Aplysia californica].
The effect of 1,3-dimethyl-5-aminoadamantane (DMAA, D-145, memantine, Memantine) in the concentration range of 10(-6) to 10(-3) mol/l was investigated on membrane properties and synaptic transmission by the current or voltage clamp method on neurons in the visceral ganglion of Aplysia california. In the lower range (concentrations 10(-6) to 10(-5) mol/l) the substance increases the speed of voltage changes during the course of the action potential, increases spontaneous synaptic activity, and induces a slight membrane depolarization. With increasing concentration the effects reverse in that slope of action potential is slowed and synaptic transmission delayed or blocked. At the RC-R15 synapse, isolated from its interneuron, 10(-5) mol/l DMAA evokes spontaneously and regularly firing EPSPs; 10(-3) mol/l blocks both, spontaneous activity, and its responsiveness to electrical stimulation.
D000200:Action Potentials / Q000187:drug effects; D000547:Amantadine / Q000031:analogs & derivatives*; D000818:Animals; D001048:Aplysia / Q000187:drug effects*; D004558:Electric Stimulation; D008559:Memantine / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D008566:Membranes / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D000547:Amantadine; D008559:Memantine
Die Wirkung von Memantin auf Membraneigenschaften und postsynaptische Potentiale von Nervenzellen der Aplysia californica.