title: Herpetic proctitis and meningitis: recovery of two strains of herpes simplex virus type 1 from cerebrospinal fluid.
abstract: A patient with simultaneous proctitis and meningitis due to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) was extensively investigated. In both disease locations the infection was clinically evident and culture-proven. Analysis by sodium dodecylsulfate-polyacrylamide gel electrophoresis of rectal isolates revealed both HSV-1 and HSV-2. The cerebrospinal fluid harbored two apparently different strains of HSV-1, one of which was shown by restriction endonuclease analysis to be identical with the rectal isolate of HSV-1.
mesh_terms: D000328:Adult; D003588:Cytopathogenic Effect, Viral; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D006561:Herpes Simplex / Q000134:cerebrospinal fluid* / Q000150:complications / Q000382:microbiology; D006801:Humans; D008297:Male; D008581:Meningitis / Q000150:complications / Q000209:etiology / Q000382:microbiology*; D011349:Proctitis / Q000150:complications / Q000209:etiology / Q000382:microbiology*; D018139:Simplexvirus / Q000254:growth & development / Q000302:isolation & purification*; D014776:Virus Cultivation
chemical_list: D004262:DNA Restriction Enzymes