Chemical inhibition of foamyvirus in primary baboon (Papio cynocephalus) kidney cells.
This report describes the conditions for the use of aluminum chloride (AlCl3) in growth and maintenance media for the suppression or inhibition of simian foamyviruses (SFV) in primary baboon kidney (BAK) and rabbit kidney (RK) cell cultures. When RK cells were planted in medium containing AlCl3, infected with SFV, and passaged, the growth of SFV was suppressed or inhibited by the presence of AlCl3. With this method, BAK cells yielded higher viral titers after infection with various viruses, thus making these cells more suitable for virological applications.
D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured / Q000382:microbiology*; D002712:Chlorides; D003470:Culture Media; D006564:Herpesviridae / Q000254:growth & development; D007668:Kidney; D010215:Papio; D011817:Rabbits; D012190:Retroviridae / Q000254:growth & development*; D016092:Spumavirus / Q000187:drug effects / Q000254:growth & development*; D014776:Virus Cultivation
D017607:Aluminum Compounds; D002712:Chlorides; D003470:Culture Media; D000077410:Aluminum Chloride; D000535:Aluminum