Changes in rat hippocampal benzodiazepine receptors and lack of changes in muscarinic receptors after fimbria-fornix lesions.
The binding of [3H] L-quinuclidinylbenzilate to muscarinic receptors and [3H] flunitrazepam to benzodiazepine receptors were studied in the rat hippocampus after lesion of the fimbria-fornix. While the muscarinic receptors showed no change, the benzodiazepine receptors did change considerably at various time intervals. Two days after the lesion the specific [3H] flunitrazepam binding decreased 38%, while at 5 days it increased 65%. After 14 days of the lesion it still was significantly above normal. These changes are due to a variation in the number of sites, and not in affinity. Possible interpretations of these results are discussed.
D000818:Animals; D001921:Brain / Q000502:physiology*; D005445:Flunitrazepam / Q000378:metabolism; D007839:Functional Laterality; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011955:Receptors, Drug / Q000378:metabolism*; D011963:Receptors, GABA-A; D011976:Receptors, Muscarinic / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D011950:Receptors, Cholinergic; D011955:Receptors, Drug; D011963:Receptors, GABA-A; D011976:Receptors, Muscarinic; D017981:Receptors, Neurotransmitter; D005445:Flunitrazepam; D011813:Quinuclidinyl Benzilate