title: Ganglioneuroblastoma containing several kinds of neuronal peptides with watery diarrhea syndrome.
abstract: This report presents an adrenal ganglioneuroblastoma containing several kinds of neuronal peptides. The tumour was found in the autopsy case of a 3-year-old girl with clinical manifestation of intractable diarrhea, hypokalemia, achlorhydria, and with elevated levels of plasma vasoactive intestinal peptide (VIP). Immunoperoxidase staining showed many immunoreactive VIP- containing cells, some somatostatin-and substance P-containing cells on the tumour sections. Ultrastructurally, the tumour cells contained numerous secretory granules that could be divided mainly two types; one is a small cored vesicle (50-150 nm in diameter) and the other large electron dense secretory granule (200-500 nm in diameter). It was suggested that the cells in ganglioneuroblastoma derived from neural crest are closely related to the cells that could differentiate into gut-hormone-producing cells.
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000032:analysis* / Q000150:complications; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology*; D005260:Female; D005729:Ganglioneuroma / Q000032:analysis* / Q000150:complications; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D010455:Peptides / Q000032:analysis*; D013577:Syndrome; D014660:Vasoactive Intestinal Peptide / Q000032:analysis; D003969:Vipoma / Q000473:pathology
chemical_list: D010455:Peptides; D014660:Vasoactive Intestinal Peptide