[Features of the regulation of key enzymes involved in glycolysis and the pentosephosphate shunt in tissues with different functional specializations].
Under conditions of acute and chronic stress carbohydrate metabolism was decreased in muscles and liver tissue, increased in adrenal glands and unaltered in brain. cAMP at concentration 10(-5)M decreased the rate of glycolysis in liver tissue and increased it slightly in adrenal glands. The inhibitory effect of cAMP was not decreased by 2',3'-AMP and was reversed completely by the protein inhibitor of proteinkinase. cAMP inhibited hexokinase (HK) isoenzymes 2 and 3 as well as glucose-6-phosphate dehydrogenase (G6PD) isoenzymes 1 and 2, activities of HK 1 and G6PD 3 and 4 were unaltered. The decrease in activities of HK and G6PD appears to be related to phosphorylation of proteinkinase; lack of the effect of cAMP in adrenal glands was apparently due to absence of corresponding cAMP-dependent proteinkinase in this tissue.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D010428:Pentosephosphates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism*
D010428:Pentosephosphates; D000242:Cyclic AMP; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase
Osobennosti reguliatsii kliuchevykh fermentov glikoliza i pentozofosfatnogo puti v tkanikah s razlichnoĭ funktsional'noĭ spetsializatsieĭ.