Suppressive action of cholecystokinin octapeptide on the behavioral effects of L-DOPA in the rat.
Intracerebroventricular (i.c.v.) administration of cholecystokinin octapeptide (CCK-8) appeared to suppress the effects of L-DOPA and antagonize the actions of thyrotropin-releasing hormone (TRH). This was not only proved by the behavioral rating, but also by locomotor activity counting. thus, the sedative action of CCK-8 and the antagonizing effect of this peptide on the central actions of TRH were clearly demonstrated.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002766:Cholecystokinin / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors*
D010446:Peptide Fragments; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D002766:Cholecystokinin; D010293:Pargyline; D012844:Sincalide