Multiple forms and inhibitors of uridine-cytidine kinase in neoplastic cells.
1. Two forms (isozymes) of uridine (urd)-cytidine (cyd) kinase are present in the 30-50% ammonium sulfate fraction of the cytosols of L1210 ascites leukemia cells and a human malignant lymphoma. 2. These findings confirm those which described multiple forms of urd-cyd kinase in tumors with rapid growth rate. 3. Studied of inhibitors (nucleoside analogs) of urd-cyd kinase derived from L1210 and 6410 leukemia cells resulted in the finding of four possible inhibitors of this enzyme.
D000818:Animals; D002460:Cell Line; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000032:analysis* / Q000037:antagonists & inhibitors; D007700:Kinetics; D007939:Leukemia L1210 / Q000201:enzymology*; D008223:Lymphoma / Q000201:enzymology*; D051379:Mice; D010770:Phosphotransferases / Q000032:analysis*; D014529:Uridine / Q000378:metabolism; D014541:Uridine Kinase / Q000032:analysis* / Q000037:antagonists & inhibitors
D007527:Isoenzymes; D010770:Phosphotransferases; D014541:Uridine Kinase; D014529:Uridine