Promotion of benign hyperplastic lesions by calcium, magnesium and cAMP, and inhibition of tumor progression by magnesium in hamster cheek pouch.
Ca, Mg (0.1 or 0.2M) and ionophore A23187 (10(-5) - 10(-4)M) promoted benign hyperplastic lesions (BHLs) to a highly variable degree when applied topically in hamster cheek pouch after initiation with 7, 12-dimethylbenz(a)anthracene (DMBA). The changes in the promoting effects of Ca and Mg between experiments were not parallel. Mg but not Ca inhibited retinyl acetate-induced progression of BHLs to advanced tumors. Cyclic adenosine 3',5'-monophosphate (cAMP) (10(-5) - 10(-3)M) promoted BHLs. The results are discussed in terms of possible mechanisms involved.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D002610:Cheek; D006224:Cricetinae; D000242:Cyclic AMP / Q000494:pharmacology*; D005260:Female; D006965:Hyperplasia; D008274:Magnesium / Q000494:pharmacology*; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*
D000001:Calcimycin; D015127:9,10-Dimethyl-1,2-benzanthracene; D000242:Cyclic AMP; D008274:Magnesium; D002118:Calcium