Calcium effect on generation and amplification of myokymic discharges.
Maneuvers designed to manipulate ionized calcium (Ca++) were carried out in two patients with inflammatory polyradiculoneuropathy and myokymia. Increased clinical myokymia and myokymic burst amplification occurred when ionized Ca++ was lowered by plasma exchange or hyperventilation. Increasing ionized Ca++ (by intravenous infusion of CaCl2) decreased the myokymia. These findings indicate that myokymic discharges are altered by changes in serum ionized Ca++ and effects on axonal excitability.
D000328:Adult; D000368:Aged; D002118:Calcium / Q000378:metabolism*; D004576:Electromyography; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000150:complications; D008475:Median Nerve / Q000503:physiopathology; D009207:Myoclonus / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D010543:Peroneal Nerve / Q000503:physiopathology; D010951:Plasma Exchange; D014459:Ulnar Nerve / Q000503:physiopathology
D002118:Calcium