title: Gene amplification in methotrexate-resistant mouse cells. I. DNA rearrangement accompanies dihydrofolate reductase gene amplification in a T-cell lymphoma.
mesh_terms: D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D004351:Drug Resistance; D005784:Gene Amplification; D005796:Genes; D007942:Leukemia, Experimental / Q000235:genetics; D008223:Lymphoma / Q000235:genetics*; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D012333:RNA, Messenger / Q000096:biosynthesis; D013601:T-Lymphocytes; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D004247:DNA; D013762:Tetrahydrofolate Dehydrogenase; D004262:DNA Restriction Enzymes; D008727:Methotrexate