Partial purification from hepatoma cells of an intracellular substance which mediates the effects of insulin on pyruvate dehydrogenase and low Km cyclic AMP phosphodiesterase.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D000273:Adipose Tissue / Q000201:enzymology; D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000032:analysis*; D008297:Male; D008970:Molecular Weight; D011769:Pyruvate Dehydrogenase (Lipoamide)-Phosphatase / Q000037:antagonists & inhibitors; D011768:Pyruvate Dehydrogenase Complex / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology
D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex; C029131:pyruvate dehydrogenase activator; D012969:Sodium Fluoride; D011769:Pyruvate Dehydrogenase (Lipoamide)-Phosphatase; D015105:3',5'-Cyclic-AMP Phosphodiesterases