[A new observation of an H-Y antigen positive 46, XX male (author's transl)].
A new serologic test for detecting the H-Y antigen by indirect fluorescence performed on purified lymphocytes was developed. It allowed us to demonstrate H-Y antigen in an 46, XX male. The presence of this antigen explains why the primitive gonad underwent testicular differentiation. Several mechanisms could account for the presence of H-Y antigen. Mosaicism or translocation of an X on a Y or an autosome may prevent detection of a Y chromosome. Alternatively, a Y chromosome may have disappeared during embryogenesis, The last hypothesis suggests that an autosome may carry a structural gene coding for H-Y antigen; in this case thye Y chromosome would act only as an accessory regulating gene.
D000293:Adolescent; D000328:Adult; D005455:Fluorescent Antibody Technique; D006182:H-Y Antigen / Q000032:analysis*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009030:Mosaicism; D012729:Sex Chromosome Aberrations / Q000209:etiology*; D012733:Sex Differentiation; D013737:Testis / Q000196:embryology*; D014178:Translocation, Genetic; D014998:Y Chromosome
D006182:H-Y Antigen
Présence d'un antigène H-Y chez un homme 46, XX suggérant la différenciation de la gonade primitive en testicule.