title: Megaoesophagus due to acrylamide neuropathy.
abstract: Greyhound dogs exposed to oral acrylamide for a period of eight weeks developed a sensorimotor peripheral neuropathy that had many features in common with acrylamide neuropathy seen in other species. Most of the animals also developed the clinical and radiological features of megaoesophagus. The association of neuropathy and megaoesophagus suggests that an axonopathy of the vagus may be an aetiological factor in this disorder.
mesh_terms: D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D004285:Dogs; D004935:Esophageal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004947:Esophagus / Q000294:innervation; D009135:Muscular Diseases / Q000139:chemically induced; D009943:Organophosphorus Compounds / Q000633:toxicity; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D011859:Radiography; D013045:Species Specificity; D014630:Vagus Nerve
chemical_list: D000178:Acrylamides; D009943:Organophosphorus Compounds; D020106:Acrylamide