Attenuation by chronic imipramine treatment of [3H]clonidine binding to cortical membranes and of clonidine-induced hypothermia: the influence of central chemosympathectomy.
Central chemosympathectomy with intraventricular injection of 250 microgram of 6-hydroxydopamine, resulting in depression of cerebral noradrenaline level by 75% led to an increase in specific binding of [3H]clonidine to cerebral cortical membranes, but did not affect the hypothermic response to clonidine. Chronic imipramine treatment depressed [3H]clonidine binding and attenuated clonidine-induced hypothermia similarly in non-chemosympathectomized and chemosympathectomized rats.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003000:Clonidine / Q000378:metabolism* / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000378:metabolism
D006892:Hydroxydopamines; D011941:Receptors, Adrenergic; D016627:Oxidopamine; D003000:Clonidine; D007099:Imipramine; D009638:Norepinephrine