[Effect of strophanthin in adrenergic blockade on the blood supply and work of the heart in acute coronary artery occlusion].
The effects of strophathin in a dose of 0.15 mg/kg bw were investigated under alpha- and beta-adrenergic blockade by the methods of thermodilution and circulation registration in the pool of the occluded coronary artery in anesthetized dogs. It was determined that strophanthin increased the blood supply of the myocardial ischemic centres, the minute heart volume, and systemic arterial pressure and decreased the general peripheral vascular resistance. The alpha-adrenoblocker, phentolamine (0.025 mg/kg intravenously) decreased the strophanthin stimulant effect on the collateral coronary blood stream and heart activity without changing its chronotropic and vasopressive action. The beta-adrenoreceptor blockade induced by obsidan (0.5 mg/kg) made no changes in the pattern of the glycoside cardiovascular effects and diminished its chronotropic action.
D000208:Acute Disease; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D013328:Strophanthins / Q000627:therapeutic use*
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D013328:Strophanthins; D011433:Propranolol; D010646:Phentolamine
Vliianie strofantina v usloviiakh adrenergicheskoĭ blokady na krovosnabzhenie i rabotu serdtsa pri ostroĭ okkliuzii koronarnoĭ arterii.