[Effects of colchicine, cyclic nucleotides and biogenic amines on the chemoreceptor apparatus of the tongue].
Colchycine considerably decreased sensitivity of the Rana temporaria tongue's chemoreceptors to adequate stimulation. The effect is reversible and can be abolished by administration of drugs initiating setting of the cells' microtubular apparatus: 3',5'-cAMP, theophylline, adrenaline as well as by activation of the sympathetic system. The restoring effect of these agents is specific since 2',3'-cAMP, 5'-AMP, serotonin, inosine, acetylcholine and 3,'5'-cGMP prove ineffective in restoring the reactions after colchycine administration although they do alter the activity of the receptors in normal conditions. The revealed colchycine-sensitive, 3',5'-cAMP-dependent process seems to be associated with the microtubular apparatus of the receptor cell. Its role in the receptor structures is discussed.
D000249:Adenosine Monophosphate / Q000502:physiology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000502:physiology; D006152:Cyclic GMP / Q000502:physiology; D004837:Epinephrine / Q000502:physiology*; D005071:Evoked Potentials; D006157:Guanosine Monophosphate / Q000502:physiology; D009712:Nucleotides, Cyclic / Q000502:physiology*; D011896:Rana temporaria; D012701:Serotonin / Q000502:physiology*; D013268:Stimulation, Chemical; D013650:Taste Buds / Q000166:cytology / Q000502:physiology*; D013806:Theophylline / Q000494:pharmacology
D009712:Nucleotides, Cyclic; D012701:Serotonin; D000249:Adenosine Monophosphate; D003994:Bucladesine; D006157:Guanosine Monophosphate; D013806:Theophylline; D000242:Cyclic AMP; D006152:Cyclic GMP; D003078:Colchicine; D004837:Epinephrine
Vliianie kolkhitsina, tsiklicheskikh nukleotidov i biogennykh aminov na khemoretseptornyĭ apparat iazyka.