Amitriptyline-related peripheral neuropathy relieved during pyridoxine hydrochloride administration.
Tricyclic antidepressants rarely cause peripheral neuropathy. In fact, this class of drugs has been used to control the symptoms of pain and paresthesia that accompany peripheral neuropathy. We report peripheral paresthesias that occurred in a 39-year-old female during five years of amitriptyline administration. The patient's symptoms were relieved by oral pyridoxine hydrochloride, associated with elevated plasma pyridoxal phosphate.
D000328:Adult; D000639:Amitriptyline / Q000009:adverse effects*; D006801:Humans; D008094:Lithium / Q000009:adverse effects; D008297:Male; D010292:Paresthesia / Q000139:chemically induced; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy; D011736:Pyridoxine / Q000627:therapeutic use*
D000639:Amitriptyline; D008094:Lithium; D011736:Pyridoxine