title: The localization of glial fibrillary acidic protein in brain tumors induced in hamsters with avian sarcoma virus.
abstract: The immunohistochemical localization of glial fibrillary acidic protein (GFAP) was studied by the peroxidase-antiperoxidase (PAP) method in avian sarcoma virus (ASV)-induced brain tumors in hamsters. One hundred twenty-four tumors including 54 astrocytomas, 64 pleomorphic gliomas, five sarcomas, and one unclassified tumor were stained with anti-GFAP serum. A positive immunostaining was seen in astrocytomas and in pleomorphic gliomas. Sarcomas and an unclassified tumor were negative. These results confirmed that a majority of ASV-induced brain tumors contained neoplastic glial cells, and further suggested that the astrocyte is a main target cell of ASV in the experimental neuro-oncogenesis.
mesh_terms: D000818:Animals; D001254:Astrocytoma / Q000032:analysis; D001358:Avian Sarcoma Viruses; D006224:Cricetinae; D005910:Glioma / Q000032:analysis; D007124:Immunoenzyme Techniques; D009374:Neoplasms, Experimental / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009457:Neuroglia; D012509:Sarcoma / Q000032:analysis
chemical_list: D009419:Nerve Tissue Proteins