Chromosome #14 markers in two Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines of normal origin differ from the Burkitt lymphoma (BL)-associated 14q+ marker.
Two among ten Epstein-Barr Virus (EBV)-transformed lymphoblastoid cell lines contained a 14q+ marker in a low frequency of the cells (2 and 9%). By means of "mesome-prosome" analysis of the G-band patterns of these markers; it was established that the additional chromosome segments of these two 14q+ markers came from chromosomes #3 and #5, respectively, and not from chromosome #8 as in the 14q+ marker of Burkitt lymphoma. Chromosome #8 was not involved at all in any changes in the ten lymphoblastoid cell lines studied.
D000328:Adult; D002051:Burkitt Lymphoma / Q000235:genetics*; D002460:Cell Line; D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure*; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D005819:Genetic Markers; D004854:Herpesvirus 4, Human; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000382:microbiology / Q000648:ultrastructure*
D005819:Genetic Markers