title: New technologies to combat malignant tumours of the brain.
abstract: 1. The primary problem in an effective treatment of a glioblastoma is the prevention of a recurrence. 2. For that purpose were the following therapeutical procedures undertaken: (a) Temporary implantation of radio cobalt in the brain itself (1957): (b) Clostridium butyricum M 55 was used to render the centre of the tumour fluid (1967): (c) Podophyllin was used to destroy the border of the tumour (1980); (d) The CO2 Laser beam (1975); (e) The electromagnetic heat induction deep in the brain (1973-1978). 3. In order to make the operation and postoperative phase safer for the patient, the following precautions were drawn upon or employed: (a) Hyperbaric oxygenisation in the pressure chamber (1971); (b) The anti-G-suit (1974); (c) the computer controlled automatic infusion pump (1980), and (d) the telemetric measurement of intra-cranial pressure (1975). 4. Apart from the pressure chamber, the mentioned devices were all supervised and developed in the department of the author. 5. The first successful means in the prevention of the recurrence of a glioblastoma multiform seems to be the telethermic method mentioned in 2 (e) above.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001932:Brain Neoplasms / Q000175:diagnosis / Q000601:surgery* / Q000628:therapy; D002245:Carbon Dioxide / Q000627:therapeutic use; D003013:Clostridium; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005909:Glioblastoma / Q000175:diagnosis / Q000601:surgery* / Q000628:therapy; D006801:Humans; D007427:Intracranial Pressure; D053685:Laser Therapy; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011033:Podophyllin / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D014057:Tomography, X-Ray Computed
chemical_list: D003037:Cobalt Radioisotopes; D002245:Carbon Dioxide; D011033:Podophyllin