title: Clinical effectiveness of some fluoride-containing toothpastes.
abstract: Comparisons were made of the clinical effectiveness of two small groups of fluoride-containing toothpastes on the basis of published and unpublished information available to the group. One comparison showed that particular sodium fluoride/silica and stannous fluoride/calcium pyrophosphate formulations were effective in reducing the incidence of dental caries in schoolchildren and that the former toothpaste was more effective than the latter. A separate comparison showed that certain toothpastes containing sodium monofluorophosphate formulated with either an alumina or an insoluble metaphosphate abrasive were also effective in reducing and controlling caries. The group recommended that there was a need for additional field trials in which direct comparisons could be made between a wide variety of formulations, and that further research should be carried out to develop improved formulations. Extension of the use of adequately formulated fluoride-containing toothpastes is recommended as a valuable public health measure to reduce the incidence of dental caries.
mesh_terms: D002131:Calcium Pyrophosphate / Q000008:administration & dosage; D002648:Child; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D003802:Dentifrices / Q000592:standards*; D005459:Fluorides / Q000008:administration & dosage; D005460:Fluorides, Topical / Q000008:administration & dosage*; D006801:Humans; D010710:Phosphates / Q000008:administration & dosage; D012822:Silicon Dioxide / Q000008:administration & dosage; D012969:Sodium Fluoride / Q000008:administration & dosage; D014002:Tin Fluorides / Q000008:administration & dosage; D014100:Toothpastes / Q000592:standards*
chemical_list: D003802:Dentifrices; D005460:Fluorides, Topical; D010710:Phosphates; D014002:Tin Fluorides; D014100:Toothpastes; C012980:fluorophosphate; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D005459:Fluorides; D002131:Calcium Pyrophosphate