Cotransmitters in the motor nerves of the guinea pig vas deferens: electrophysiological evidence.
The contractile response of the guinea pig vas deferens to motor nerve stimulation is biphasic. The first phase is antagonized by the specific adenosine triphosphate-receptor antagonist arylazido aminoproprionyl adenosine triphosphate (ANAPP3), and the second by the alpha-receptor antagonist prazosin. The underlying electrical event, the excitatory junction potential, is also blocked by ANAPP3, but not by prazosin.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001386:Azides; D006168:Guinea Pigs; D008297:Male; D009046:Motor Neurons / Q000502:physiology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D014649:Vas Deferens / Q000294:innervation*
C012761:3'-O-(3-(N-(4-azido-2-nitrophenyl)amino)propionyl)adenosine-5'-triphosphate; D001386:Azides; D011942:Receptors, Adrenergic, alpha; D011956:Receptors, Cell Surface; D000255:Adenosine Triphosphate; D009638:Norepinephrine; D011224:Prazosin