title: [Ultrastructural characteristics of the differentiation of glandular cells in the anterior pituitary gland of collared lemmings (Dicrostonyx) from the Vrangel Island].
abstract: In 15.5-, 16-, 17.5-, 18.5-, 20-day-old fetuses and newborn lemmings, the ultrastructure of the anterior lobe of the hypophysis has been studied. In the parenchyma of the 15.5-day-old fetus gland, some cells containing secretory material are revealed, but they are difficult for identification, since differentiation of their organellas is not completed and polymorphism of their granules is strongly manifested. On the 17.5th day of the prenatal development TTH-, ACTH-, LH-, STH-secreting adenocytes are detected; they include secretory granules having diameters 70--100 nm, 80--150 nm, 60--140 nm and 200--400 nm, respectively. On the 18.5th day FSH-secreting cells are identified. Lactotropocytes appear on the 20th day. The anterior lobe of the hypophysis of 17.5--18.5-day-old fetuses are characterized by a high level of the secretory activity which decreases to some extent before birth. Ultrastructure of the cellular organellas in the newborn hypophysis is similar to that in a mature animal, nevertheless, the diameter of the secretory granules does not reach the size of these elements in mature individuals.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D003411:Arvicolinae / Q000033:anatomy & histology*; D002454:Cell Differentiation; D004622:Embryo, Mammalian; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000196:embryology / Q000378:metabolism / Q000648:ultrastructure*; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin
vernacular_title: Ul'trastrukturnaia kharakteristika spetsializatsii zhelezistykh kletok v peredneĭ dole gipofiza u osheĭnikovogo lemminga o-va Vrangelia.