In vitro metabolism of acrylonitrile to 2-cyanoethylene oxide, reaction with glutathione, and irreversible binding to proteins and nucleic acids.
D000181:Acrylonitrile / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D004247:DNA / Q000378:metabolism; D005027:Ethylene Oxide / Q000031:analogs & derivatives* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006856:Hydrogen Cyanide / Q000378:metabolism; D008658:Inactivation, Metabolic; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009570:Nitriles / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats
D009570:Nitriles; C033154:2-cyanoethylene oxide; D006856:Hydrogen Cyanide; D004247:DNA; D006899:Mixed Function Oxygenases; D005978:Glutathione; D005027:Ethylene Oxide; D000181:Acrylonitrile