title: Failure of TRH and ORG 2766 hexapeptide to counteract alcoholic inebriation in man.
abstract: The actions and interactions of alcohol (1.5 g/kg) and two stimulant peptides were investigated in healthy volunteers. Double blind and cross over studies in 8 subjects, at one-week intervals, revealed that ORG 2766 (5 or 20 mg i.m.) and particularly TRH (10 micrograms/kg i.v.) enhanced rather than antagonized alcohol-induced inebriation. The interactions were associated with elevated breath alcohol concentrations. Similar studies with 8 other subjects showed that peptides given in combination with a non-alcoholic drink tended to impair performance assessed as various psychophysiological variables. However, ORG 2766 5 mg was subjectively rated as producing a feeling of improved performance.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000328:Adult; D004347:Drug Interactions; D000431:Ethanol / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D013647:Task Performance and Analysis; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
chemical_list: D010446:Peptide Fragments; D000431:Ethanol; C013765:Org 2766; D013973:Thyrotropin-Releasing Hormone; D000324:Adrenocorticotropic Hormone