Conditioned taste aversion following acutely administered acrylamide.
Fischer-344 rats were acclimated to a daily 15 min period of water availability. After water consumption had stabilized, the rats were permitted a 15 min access to 0.15% (w/v) solution of saccharin. One to two min following saccharin presentation, they were given various doses of acrylamide (10-50 mg/kg) or lithium chloride (LiCl; 3 mEq/kg) by gavage. Three days later, aversion to the saccharin solution was determined. Acrylamide, like LiCl, produced an aversion to saccharin. The effect of acrylamide appeared to be dose-related with the threshold dose being 10 mg/kg.
D000178:Acrylamides / Q000506:poisoning*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002712:Chlorides / Q000506:poisoning*; D003214:Conditioning, Classical / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D008094:Lithium / Q000506:poisoning*; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013649:Taste / Q000187:drug effects*
D000178:Acrylamides; D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride