[Effect of polymyxin B on ion permeability of bacterial membranes].
Effect of polymyxin B on the movement of K+ and H+ in polymyxin-sensitive cells of E. coli under different metabolic states has been studied. It was shown that polymyxin B induced the efflux of K+, decreased the efflux of H+ and inhibited the consumption of oxygen in bacterial cells. The effect of antibiotic on ion movement was independent of respiratory conditions. It was suggested that polymyxin B increased ion permeability and destroyed lipid-protein interactions of the respiratory chain simultaneously.
D002463:Cell Membrane Permeability / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D010101:Oxygen Consumption / Q000187:drug effects; D011112:Polymyxin B / Q000494:pharmacology*; D011113:Polymyxins / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism
D011113:Polymyxins; D011112:Polymyxin B; D011188:Potassium
Vliianie polimiksina B na ionnuiu pronitsaemost' bakterial'nykh membran.