Effect of cholecystokinin on thyrotropin releasing hormone (TRH)-induced serotonin potentiation in rats.
Cholecystokinin octapeptide (CCK-8) did not affect the behavioral syndrome of rats treated with pargyline and 5-hydroxytryptamine, while TRH produced a marked behavioral excitation under the same condition. However, the serotonin-potentiating effect of TRH was apparently suppressed by simultaneous administration of CCK-8.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D012844:Sincalide; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D010446:Peptide Fragments; D012701:Serotonin; D013973:Thyrotropin-Releasing Hormone; D002766:Cholecystokinin; D010293:Pargyline; D006916:5-Hydroxytryptophan; D012844:Sincalide