[Effects of isaxonine on experimentally induced vincristine neuropathy in rabbits (author's transl)].
The effect of isaxonine on neuropathy induced by vincristine in the rabbit was studied using clinical, electrophysiological and histological parameters. Isaxonine protects against early adverse reactions of vincristine administration such as decrease in food consumption and body weight, an alopecia. Motor disturbance was reduced. This protective effect is confirmed by electrophysiological tests (motor latency, muscular strength of tibialis anterior muscle). Isaxonine decrease the incidence of the neuropathy induced by vincristine in the rabbit.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004558:Electric Stimulation; D009119:Muscle Contraction / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology*; D011743:Pyrimidines / Q000494:pharmacology*; D011817:Rabbits; D013497:Sural Nerve / Q000473:pathology; D014750:Vincristine / Q000494:pharmacology*
D011743:Pyrimidines; D014750:Vincristine; C020375:isaxonine
Effets de l'isaxonine sur la neuropathie expérimentale à la vincristine chez le lapin.