Effect of pyridines on phenotypic properties of Bordetella pertussis.
Several conditions of growth of Bordetella pertussis cause a reversible phenotypic alteration in properties termed modulation. Growth in medium containing nicotinic acid induces normal (X-mode) cells to change to modulated (C-mode) cells. We examined several pyridines and compounds resembling pyridines for their ability to affect modulation, using envelope protein patterns and serological reactivity as indicators of modulation. We found that 6-chloronicotinic acid and quinaldic acid were more effective modulating stimuli than was nicotinic acid on a molar basis. Both 2-chloronicotinamide and isoniazid interfered with nicotinic acid-induced modulation, and can be called antimodulators. Picolinic acid inhibited growth.
D000372:Agglutination Tests; D001426:Bacterial Proteins / Q000502:physiology*; D001886:Bordetella pertussis / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D007538:Isoniazid / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D009525:Niacin / Q000494:pharmacology; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D009539:Nicotinic Acids / Q000494:pharmacology; D010848:Picolinic Acids / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D009539:Nicotinic Acids; D010848:Picolinic Acids; D011725:Pyridines; D011804:Quinolines; C035952:2-chloronicotinamide; D009536:Niacinamide; D009525:Niacin; C035953:6-chloronicotinic acid; D008274:Magnesium; C008898:quinaldic acid; D007538:Isoniazid