A noninvasive method for evaluating portal circulation by administration of Ti-201 per rectum.
A new method for evaluating portal systemic circulation by administration of TI-201 per rectum was performed in 13 control subjects and in 65 patients with various liver diseases. In normal controls, the liver was visualized on the 0--5-min image whereas the images of other organs such as the heart, spleen, and lungs were very poor. In patients with liver cirrhosis associated with portal-systemic shunt, and in many other patients with hepatocellular damage, the liver was not so clearly visualized, whereas radioactivity in other organs, especially the heart, became evident. The heart-to-liver uptake ratio at 20 min after administration (H/L ratio) was significantly higher in liver cirrhosis than in normals and patients with chronic hepatitis (p less than 0.001). The patients with esophageal varices showed a significantly higher H/L ratio compared with that in cirrhotic patients without esophageal varices (p less than 0.001). The H/L ratio also showed a significant difference (p less than 0.01) between Stage 1 and Stage 3 esophageal varices. Since there were many other patients with hepatocellular damage who had high H/L ratios similar to those in liver cirrhosis, the effect that hepatocellular damage has on the liver uptake of TI-201 is also considered. Our present data suggest that this noninvasive method seems to be useful in evaluating portal-to-systemic shunting.
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging; D004932:Esophageal and Gastric Varices / Q000000981:diagnostic imaging; D005260:Female; D006505:Hepatitis / Q000000981:diagnostic imaging; D006801:Humans; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging; D008105:Liver Cirrhosis, Biliary / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011170:Portasystemic Shunt, Surgical; D011868:Radioisotopes / Q000008:administration & dosage*; D011877:Radionuclide Imaging; D012007:Rectum; D013793:Thallium / Q000008:administration & dosage*
D011868:Radioisotopes; D013793:Thallium