title: Structure and evolution of the heavy chain from rat immunoglobulin E.
abstract: The nucleotide sequence of the rat epsilon-chain mRNA has been determined by sequencing cloned cDNA copies of the mRNA. The established sequence covers the coding region, the 3'-non coding region and most of the 5' non-coding region. A comparison with the nucleotide sequence of the human epsilon-chain constant region reveals that C3 and C4 are the most highly conserved domains. The rat epsilon-chain contains a C-terminal decapeptide which is not present in the human counterpart.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA; D004262:DNA Restriction Enzymes; D007073:Immunoglobulin E / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D009374:Neoplasms, Experimental / Q000276:immunology; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats
chemical_list: D007143:Immunoglobulin Heavy Chains; D012333:RNA, Messenger; D007073:Immunoglobulin E; D004247:DNA; D004262:DNA Restriction Enzymes