Unusual intranuclear inclusions in malignant fibrous histiocytoma: presence in primary tumor, metastases, and xenografts.
We describe previously unreported intranuclear inclusions in 2 cases of malignant fibrous histiocytoma. The inclusions were found in 2-10% of the tumor cells removed from the patients and in 2-10% of the cells examined in tumor tissue xenotransplanted in nude mice. By stereo electron microscopy the inclusions are closely packed undulating fibrils 18-23 nm in diameter. They are sometimes associated with fibrillary bodies. They closely resemble the inclusions reported in some animals inoculated with serum from patients with non-A non-B hepatitis; however, their nature at present is unknown.
D000328:Adult; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure*; D006570:Heterochromatin / Q000648:ultrastructure; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000648:ultrastructure*; D014183:Transplantation, Heterologous
D006570:Heterochromatin