title: Occurrence and properties of composite transposon Tn2672: evolution of multiple drug resistance transposons.
abstract: We found Tn2671 (the 23-kb long IS1-flanked r-determinant of NR1-Basel) inserted into the ampicillin resistance gene bla of the Tn3-related transposon Tn902. The resulting 28-kilobase-long composite transposon Tn2672 (= Tn902 bla::Tn2671) is stable, and it translocates as a unit into various loci including IS1 of the resistance transfer factor of R100-1. These results are discussed with respect to the evolution of R plasmids providing multiple drug resistance.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003090:Coliphages / Q000235:genetics; D004251:DNA Transposable Elements; D004926:Escherichia coli / Q000235:genetics*; D011815:R Factors; D011995:Recombination, Genetic
chemical_list: D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements