title: Enzymatic changes in the male reproductive organs by delta-9-tetrahydrocannabinol.
abstract: Like most psychoactive agents, cannabis and its active component delta-9-tetrahydrocannabinol (delta 9-THC) have been reported to affect the neuroendocrine axis in animals. The effect of delta 9-THC on some of the functionally important enzymes of the male reproductive organs are reported. The study indicates that delta 9-THC reduces the activities of the enzymes, beta-glucuronidase, alpha-glucosidase acid phosphatase and fructose-6-phosphatase in a dose related manner in the testis, prostate as well as in the epididymis. It may be concluded that delta 9-THC may interfere with the normal functioning of the male reproductive organs.
mesh_terms: D000135:Acid Phosphatase / Q000037:antagonists & inhibitors; D000818:Animals; D013759:Dronabinol / Q000633:toxicity*; D004791:Enzyme Inhibitors; D004822:Epididymis / Q000187:drug effects / Q000201:enzymology; D005966:Glucuronidase / Q000037:antagonists & inhibitors; D065089:Glycoside Hydrolase Inhibitors; D008297:Male; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors; D011467:Prostate / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D013759:Dronabinol; C034215:fructose-6-phosphatase; D000135:Acid Phosphatase; D010744:Phosphoric Monoester Hydrolases; D005966:Glucuronidase