Biogenic amine metabolites in human lung tumor cells: histochemical and mass-spectrographic demonstration.
Three continuous cell lines isolated from small cell carcinoma of the lung (SCCL) have been examined for their ability to take up and metabolize the biogenic amine precursors, L-DOPA and 5-hydroxytryptophane (5-HTP). In two of the three lines formaldehyde-induced fluorescence (FIF) and mass-spectrographic analysis indicated specific uptake and metabolism of L-DOPA and 5-HTP.
D001679:Biogenic Amines / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D002460:Cell Line; D008401:Gas Chromatography-Mass Spectrometry; D006651:Histocytochemistry; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008175:Lung Neoplasms / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology
D001679:Biogenic Amines; D012701:Serotonin; D007980:Levodopa