Two different rheumatoid factor-producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators.
The subsets of human peripheral blood B lymphocytes from which Epstein Barr virus- (EBV) and pokeweed mitogen- (PWM) induced IgM anti-IgG autoantibody-producing B cells arise have been compared. EBV-induced IgM anti-IgG autoantibodies preferentially derive from a subset of B cells that forms rosettes with mouse erythrocytes. In contrast, PWM-induced IgM anti-IgG antibodies preferentially arise from a B cell subset lacking the mouse erythrocyte receptor.
D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D004854:Herpesvirus 4, Human; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D011043:Pokeweed Mitogens; D011971:Receptors, Immunologic / Q000032:analysis; D012217:Rheumatoid Factor / Q000096:biosynthesis*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D007075:Immunoglobulin M; D011043:Pokeweed Mitogens; D011971:Receptors, Immunologic; D012217:Rheumatoid Factor