Hypothyroidism elicits electrophysiological noradrenergic subsensitivity in rat cerebellum.
discharge rats of Purkinje neurons were compared in control and hypothyroid adult rats. Purkinje neurons in hypothyroid rats fired significantly faster and were less sensitive to iontophoretically applied norepinephrine than those in control rats. The subsensitivity of the Purkinje neurons appeared to be primarily due to an alteration in the beta-receptor--adenylate cyclase complex, because the sensitivity of these cells to locally applied N6-monobutyryl adenosine 3'-5'-monophosphate (N6 cyclic AMP) did not change significantly. The sensitivity of the Purkinje neurons to norepinephrine could be restored in hypothyroid rats by administration of triiodothyronine.
D000200:Action Potentials / Q000187:drug effects; D000262:Adenylyl Cyclases / Q000378:metabolism; D000320:Adrenergic Fibers / Q000503:physiopathology*; D000818:Animals; D002531:Cerebellum / Q000503:physiopathology*; D000242:Cyclic AMP / Q000378:metabolism; D007037:Hypothyroidism / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D011690:Purkinje Fibers / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D014284:Triiodothyronine / Q000494:pharmacology*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D014284:Triiodothyronine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D009638:Norepinephrine