[Serum profile of inflammatory reaction proteins in arteriopathies of the lower limbs, stage II].
The serum content of proteins involved in the inflammatory process was investigated, partly through kinetic immunodiffusion, in 85 men subdivided as follows: 45 men (aged 57 +/- 5 years) with intermittent claudication due to arteriosclerosis obliterans; 20 controls matched for sex and age; 20 sex-matched controls whose mean age was 25 +/- 3 years. Patients with obliterating arteriosclerosis had signs of both subacute and chronic inflammation. Compared to controls, they had a higher sedimentation rate, a lower percentage of serum albumine, higher percentages and absolute serum contents os alpha 1, alpha 2 and beta globulins, and higher serum concentrations of fibrin, orosomucoid, C3 complement fraction and IgA. In addition, the modifications of these proteins were closely correlated. These results are consistent with previous reports concerning patients with coronary heart disease. They point out the relationship between inflammation and atherosclerosis.
D000328:Adult; D001161:Arteriosclerosis / Q000097:blood; D001162:Arteriosclerosis Obliterans / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D006801:Humans; D005779:Immunodiffusion; D007249:Inflammation / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D001798:Blood Proteins
Profil sérique des protéines de la réaction inflammatoire dans les artériopathies des membres inférieurs au stade II.