title: Demonstration of albumin receptors on isolated human hepatocytes by light and scanning electron microscopy.
abstract: The presence of albumin receptors on the plasma membrane of isolated human hepatocytes was investigated employing albumin-coupled latex minibeads. Hepatocyte-latex reaction was visualized by phase contrast and scanning electron microscopy. The experiments demonstrate that hepatocytes exhibit binding activity for polymeric and monomeric forms of glutaraldehyde-treated albumin. Additionally, the reaction was shown to be species-nonspecific. These findings support the hypothesis that polymerized albumin may act as a bridge between receptors on hepatitis B virus and human hepatocytes.
mesh_terms: D002462:Cell Membrane / Q000648:ultrastructure; D006801:Humans; D008099:Liver / Q000032:analysis* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface / Q000032:analysis*
chemical_list: D017457:Receptors, Albumin; D011956:Receptors, Cell Surface