title: Effects of pH on the activity of ketoconazole against Candida albicans.
abstract: The activity of ketoconazole against Candida albicans in Sabouraud glucose medium was markedly influenced by pH. Minimum inhibitory concentrations of this imidazole against both a standard strain and clinical isolates ranged from 40 mug/ml at pH 3 to 0.02 mug/ml at pH 7, a greater than 1,000-fold difference.
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology*; D007654:Ketoconazole; D010879:Piperazines / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D007093:Imidazoles; D010879:Piperazines; D007654:Ketoconazole