Reversible resistance to the renal action of parathyroid hormone in human vitamin D deficiency.
1. The response to exogenous parathyroid hormone (PTH) was tested in normal subjects and patients with osteomalacia due to vitamin D deficiency; 200 MRC units of bovine PTH were administered intravenously. 2. The rise in plasma adenosine 3':5'-cyclic monophosphate (cyclic AMP) and the increase in urinary excretion of cyclic AMP were reduced in the patients with vitamin D deficiency. After treatment with vitamin D the responses returned to normal. 3. It is suggested that this reversible resistance is due to the secondary hyperparathyroidism associated with vitamin D deficiency.
D015652:25-Hydroxyvitamin D 2; D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D003401:Creatine / Q000097:blood; D000242:Cyclic AMP / Q000097:blood / Q000652:urine; D004872:Ergocalciferols / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014808:Vitamin D Deficiency / Q000378:metabolism / Q000503:physiopathology*
D004872:Ergocalciferols; D010281:Parathyroid Hormone; D015652:25-Hydroxyvitamin D 2; D000242:Cyclic AMP; D003401:Creatine; D002118:Calcium