Regulation by human chorionic gonadotropin of protein kinases in rabbit endometrium.
The effect of human chorionic gonadotropin (CG) on protein kinase levels has been studied in rabbit endometrium. A good correlation was observed between alterations of total protein kinase activity and DNA content in the tissue. The level of type I cyclic AMP-dependent protein kinase had slightly increased by 6 h after human CG treatment, and then decreased later. In contrast, the type II enzyme gradually increased after 3 days. The increase of the activity at 7 days was mainly due to that of type II enzyme, and the ratio of type II to type I enzyme increased. The activity pattern at the later stage closely resembled that of treatment with progesterone.
D000818:Animals; D002364:Caseins / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D002848:Chromatography, DEAE-Cellulose; D000242:Cyclic AMP / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D004247:DNA / Q000378:metabolism; D004717:Endometrium / Q000201:enzymology*; D005260:Female; D006801:Humans; D010774:Phosvitin / Q000378:metabolism; D011479:Protamines / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D011817:Rabbits
D002364:Caseins; D006063:Chorionic Gonadotropin; D011479:Protamines; D004247:DNA; D010774:Phosvitin; D000242:Cyclic AMP; D011494:Protein Kinases