Effect of the arginine analog canavanine on the synthesis of Epstein-Barr virus-induced proteins in superinfected Raji cells.
The addition of canavanine to cultures of superinfected Raji cells in the absence of arginine prevented the appearance of early antigens as defined by immunofluorescent staining. Addition of various amounts of arginine permitted the identification of at least three groups of proteins, each responding differently to the various concentrations of arginine-canavanine.
D000956:Antigens, Viral / Q000096:biosynthesis*; D001120:Arginine / Q000378:metabolism; D002172:Canavanine / Q000494:pharmacology*; D002460:Cell Line; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006801:Humans; D014764:Viral Proteins / Q000096:biosynthesis*
D000956:Antigens, Viral; D014764:Viral Proteins; D002172:Canavanine; D001120:Arginine