Protection and potentiation of nitrogen mustard cytotoxicity by WR-2721.
The radioprotective agent WR-2721 was examined for its effects on modifying the cytotoxicity of HN2 against normal and tumor cells in the AKR mouse. Quantitation was carried out by the spleen colony assay for both normal hematopoietic stem cells and AKR leukemia cells. Protection from drug toxicity and normal cell cytotoxicity was noted. Potentiation of cytotoxicity to AKR leukemia was found.
D004999:Amifostine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004347:Drug Interactions; D004357:Drug Synergism; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008466:Mechlorethamine / Q000627:therapeutic use / Q000633:toxicity*; D051379:Mice; D008806:Mice, Inbred AKR; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*
D009946:Organothiophosphorus Compounds; D008466:Mechlorethamine; D004999:Amifostine