Myocardial damage following transthoracic direct current countershock in newborn piglets.
The effect of transthoracic direct current countershock on the myocardium of 21 newborn piglets was studied. Myocardial damage was quantified by measuring the myocardial uptake of technetium-99m pyrophosphate injected 24 hours after countershock. Substantial myocardial damage occurred in animals given greater than 150 joules/kg but not at lower energy doses. Damage occurred in both ventricular free walls, but more frequently in the right ventricle. The epicardial half of the myocardium was more severely affected than the endocardial half. The relationship between myocardial damage and total countershock energy dose was well modeled by an exponential function. Transthoracic direct current countershock appears unlikely to cause myocardial damage in newborn piglets unless greatly elevated energy doses are employed.
D000818:Animals; D000831:Animals, Newborn; D011756:Diphosphates; D004554:Electric Countershock / Q000009:adverse effects*; D004562:Electrocardiography; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D013552:Swine; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate
D011756:Diphosphates; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium