Biochemical indices of sympathetic activity in migraine.
Plasma levels of adrenaline, noradrenaline, cAMP, free fatty acids and serum DBH, were estimated in a group of ten migrainous patients before, during and after a migraine attack. All parameters, apart from adrenaline, showed a statistically significant elevation during the headache period. As the blood concentration of the above substances taken in combination is the most reliable index of sympathetic activity available at present, these findings indicate that there is considerable sympathetic dysfunction during the migraine attack.
D000328:Adult; D000242:Cyclic AMP / Q000097:blood; D004299:Dopamine beta-Hydroxylase / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000201:enzymology / Q000503:physiopathology*; D009638:Norepinephrine / Q000097:blood; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D005230:Fatty Acids, Nonesterified; D000242:Cyclic AMP; D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine; D004837:Epinephrine