HLA and trophoblastic disease.
The susceptibility of trophoblastic diseases is not associated with HLA antigens. Compatibility studies between the patient and her husband, and the patient and the tumour suggest that it may not play an important role in the susceptibility or the progression of the tumour. This as well as other direct evidence indicate that the tumour cells probably do not express much HLA antigens on their cell surface. The expression of HLA antigens on normal and abnormal trophoblasts are discussed.
D000917:Antibody Formation; D002822:Choriocarcinoma / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D008285:Major Histocompatibility Complex; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000276:immunology*; D014594:Uterine Neoplasms / Q000276:immunology*
D006680:HLA Antigens