Susceptibility of zygomycetes to amphotericin B, miconazole, and ketoconazole.
Susceptibility to amphotericin B, miconazole, and ketoconazole was determined for 25 clinical isolates of zygomycetes in yeast nitrogen base broth and human serum. In yeast nitrogen base broth, 7 of 25 isolates were susceptible to an imidazole or amphotericin B. In serum, all were resistant to the imidazoles and inhibited by amphotericin B, the current drug of choice for infections caused by zygomycetes.
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D003470:Culture Media; D005658:Fungi / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D007654:Ketoconazole; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; D007093:Imidazoles; D010879:Piperazines; D008825:Miconazole; D000666:Amphotericin B; D007654:Ketoconazole