Local control of inflammatory pain.
The mechanism of the local hyperalgesic action of prostaglandin E2 has been studied using rat paw oedema. Prostaglandin E2 is a metabotropic transmitter, activating adenylate cyclase, either directly or through the release of a stimulatory protein factor. This activation of adenylate-cyclase is blocked, locally, by opiates. Hyperalgesia results from the alteration of the cAMP/Ca2+ balance after chemical or mechanical initiation of generator potentials at the nociceptor.
D000262:Adenylyl Cyclases / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000503:physiopathology*; D011458:Prostaglandins E / Q000502:physiology; D009435:Synaptic Transmission
D011458:Prostaglandins E; D003513:Cycloheximide; D000262:Adenylyl Cyclases