title: [Specific class M immunoglobulins in viral hepatitis A patients (their diagnostic and prognostic significance)].
abstract: The study included 119 children and 138 adults suffering from viral hepatitis A. The controls consisted of 114 adult patients with hepatitis B. Examinations of the total antibody to hepatitis. A virus revealed a rise in titres from 1 : 450 in the first days of the disease to 1 : 4 400 in the convalescent period. In the acute period the antibodies were represented by immunoglobulins M which circulate in the blood up to 4-5 months of convalescence. At 3-4 weeks after the onset of the disease, synthesis of immunoglobulins G begins which are anamnestic antibodies. The importance of specific immunoglobulins M in virus elimination from the host and their role in the early diagnosis of the disease have been demonstrated.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D002648:Child; D006506:Hepatitis A / Q000175:diagnosis* / Q000276:immunology; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D008875:Middle Aged; D011379:Prognosis
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M
vernacular_title: Spetsificheskie immunoglobuliny klassa M u bol'nykh virusnym gepatitom A (diagnosticheskoe i prognosticheskoe znachenie).