Effects of dithiocarb and (+)-catechin against carbon tetrachloride-alcohol-induced liver fibrosis.
Treatment of male rats with carbon tetrachloride (CCl4, 2 x weekly 0.2 ml/kg p.o.) and a 5% alcohol solution, instead of drinking water, for 4 weeks led to marked increases in serum enzyme activities (GOT, GPT, SDH), hepatic triglyceride and hydroxyproline content. Diethyl dithiocarbamate (dithiocarb, 200 mg/kg p.o.) simultaneously applied with CCl4 totally suppressed the elevation in serum enzyme activities and hepatic hydroxyproline concentration, and partially suppressed that of the triglyceride content. (+)-Catechin (50-300 mg/kg p.o.) simultaneously applied with CCl4 had no influence on the enhanced serum enzymes, but depressed the augmented content of both hepatic triglyceride and hydroxyproline in a dose-dependent way. The most effective dose with respect to the reduction of the hydroxyproline concentration was 100 mg/kg (+)-catechin; the highest dose (300 mg/kg), however, enhanced the CCl4-alcohol-induced hydroxyproline augmentation.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002392:Catechin / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis; D004050:Ditiocarb / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D006909:Hydroxyproline / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013859:Thiocarbamates / Q000494:pharmacology*
D001578:Benzopyrans; D013859:Thiocarbamates; D000431:Ethanol; D002392:Catechin; D003094:Collagen; D004050:Ditiocarb; D002251:Carbon Tetrachloride; D006909:Hydroxyproline