[Potentiative effects of angiotensin converting enzyme inhibitors on carrageenan-induced edema in rats].
Carrageenan-induced edema of rat paw was greatly potentiated by orally or locally administered angiotensin converting enzyme (CE, identical with kininase II) inhibitor, (4R)-3-[(2S)-3-mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (YS980). The potentiative effect of YS980 was observed by the administration not only prior to but also 3 hr after the carrageenan injection. The vascular permeability test showed the same potentiative effect of YS980 in the inflamed tissue of carrageenan edema. Bradykinin potentiating peptide-B (BPP-B) and 1,10-phenanthroline also potentiated the edema and the effects of these compounds were in order of YS980 greater than BPP-B greater than 1,10-phenanthroline. The order was in accordance with that of inhibitory potencies against kininase II activity of rat serum in vitro. However, the activity of kininase I was not affected by YS980 and BPP-B. In addition, among various experimental models of acute paw edema, the potentiative effects of YS980 were restricted to the inflammations mediated by kinins such as carrageenan, cellulose sulfate, kaolin and bradykinin-induced edema. These results suggest that the potentiative effect of YS980 on carrageenan edema is mainly based on its inhibitory effect on kininase II in the inflamed site.
D015097:3-Mercaptopropionic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced*; D001121:Lysine Carboxypeptidase / Q000037:antagonists & inhibitors; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology; D010618:Phenanthrolines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds; D053778:Thiazolidines
D000806:Angiotensin-Converting Enzyme Inhibitors; D009842:Oligopeptides; D010618:Phenanthrolines; D013438:Sulfhydryl Compounds; D053778:Thiazolidines; C006791:bradykinin potentiating factors; C019135:(4R)-3-((2S)-3-mercapto-2-methylpropanoyl)-4- thiazolidinecarboxylic acid; D002351:Carrageenan; D015097:3-Mercaptopropionic Acid; D001121:Lysine Carboxypeptidase