[Effects of clonidine on opiate withdrawal symptoms. Results - biochemical mechanisms (author's transl)].
Clonidine was administered to nineteen patients in an inpatient setting after abrupt discontinuation of chronic opiate addiction (morphine, héroin, dextromoramide). Clonidine produces a decrease sometimes very rapid in opiate withdrawal signs but does not suppress the whole affects associated with. These data support the hypothesis that clonidine has antiwithdrawal effect by replacing opiate-mediated inhibition with alpha 2 mediated inhibition of brain noradrenergic activity.
D000328:Adult; D003000:Clonidine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D011941:Receptors, Adrenergic; D003000:Clonidine; D009638:Norepinephrine
Application de la clonidine au traitement de l'état de manque des toxicomanies opiacées. Résultats thérapeutiques, mécanismes d'action.