Tocopherol in irradiation of experimental neoplasms. Influence of dose and administration.
The influence of tocopherol, administered intramuscularly in different single doses, on the effect of local irradiation of a transplanted rat sarcoma was investigated. Tocopherol in doses of 5, 25 or 50 mg/100 g body weight enhanced significantly the tumour growth retardation induced by irradiation. Tocopherol in a dose of 100 mg/100 g body weight as a placebo preparation had no similar effect. The influence of tocopherol administered intramuscularly or orally in identical doses was similar.
D000284:Administration, Oral; D000818:Animals; D007273:Injections, Intramuscular; D009368:Neoplasm Transplantation; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000532:radiotherapy*; D014810:Vitamin E / Q000008:administration & dosage*
D011837:Radiation-Protective Agents; D014810:Vitamin E