Xanthine derivatives that selectively inhibit cyclic GMP hydrolysis potentiate cardiac contractile effects of isoproterenol but not those of bethanecol.
D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006868:Hydrolysis; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D011817:Rabbits; D014970:Xanthines / Q000494:pharmacology*
D001626:Bethanechol Compounds; D014970:Xanthines; D000242:Cyclic AMP; D006152:Cyclic GMP; D007545:Isoproterenol