[Canine osteosarcoma as a model in comparative oncology].
Osteogenic sarcomas constitute 80% of all bone tumors in dogs, i.e. approximately 4% of canine tumors. Canine and human osteosarcomas have many clinical and pathological features in common. Epidemiological studies have provided interesting data: larger canine breeds are subject to excess risk of primary bone sarcoma, probably as high as thirty times the risk in small dogs. The appendicular skeleton, namely the metaphyses of long bones, is a preferential initial site of the tumor, and this involvement increases with the weight class of the animals. These data suggest that body size, weight or growth rate may act as factors of bone sarcoma development. Therapeutic trials on canine osteosarcoma are ongoing and could be used as models for the human counterpart.
D000818:Animals; D001859:Bone Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008297:Male; D012516:Osteosarcoma / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D013997:Time Factors
Le sarcome ostéogène (ostéosarcome) du chien. Modèle en cancérologie comparée.