The persistence of papovavirus BK DNA sequences in normal human renal tissue.
Evidence has accumulated indicating that BK virus, following an inapparent primary infection, persists in the renal organs of normal healthy individuals and reactivates upon immunosuppression. Data to support this hypothesis are presented and suggest that BK virus DNA sequences are present at very low levels in the kidneys of more than 50% of the population and that this persistence is localized in several foci within these organs.
D000368:Aged; D001739:BK Virus / Q000032:analysis*; D001483:Base Sequence; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000032:analysis*; D007672:Kidney Cortex / Q000032:analysis; D007679:Kidney Medulla / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D011120:Polyomavirus / Q000032:analysis*
D004279:DNA, Viral; D004262:DNA Restriction Enzymes