title: Effect of hCG, cAMP and FSH on steroidogenesis by human corpora lutea in vitro.
abstract: Human corpora lutea of various ages were minced and incubated in the presence of hCG (10 i.u./ml), cAMP (10 mM) or FSH (20 mu/ml) and production of progesterone and oestradiol was measured. Cyclic AMP and hCG stimulated progesterone and oestradiol production during at least the mid- and late luteal phases, but FSH stimulated only oestradiol production during the early and mid-luteal phases and had no effect on progesterone production. This demonstrates that progesterone and oestradiol synthesis by the human corpus luteum can be independently controlled.
mesh_terms: D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003338:Corpus Luteum / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology*; D004958:Estradiol / Q000096:biosynthesis; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D011374:Progesterone / Q000096:biosynthesis; D011863:Radioimmunoassay
chemical_list: D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP