Quisqualic acid excitation of cortical neurones is selectively antagonized by streptomycin.
Although evidence exists for at least 3 kinds of excitatory amino acid receptor in the CNS, responding to N-methyl-D-aspartic acid, kainic acid and quisqualic acid, respectively, only antagonists at the former two sites are currently available. It is now reported that when applied by microiontophoresis to neurones in the rat cerebral cortex, excitatory responses to quisqualic acid can be selectively reduced by streptomycin.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects*; D005071:Evoked Potentials / Q000187:drug effects; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D016202:N-Methylaspartate; D009467:Neuromuscular Depolarizing Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D010069:Oxadiazoles / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013307:Streptomycin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D009467:Neuromuscular Depolarizing Agents; D010069:Oxadiazoles; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D007608:Kainic Acid; D013307:Streptomycin