title: Cellular lung dosimetry for inhaled radon decay products as a base for radiation-induced lung cancer risk assessment. I. Calculation of mean cellular doses.
abstract: Lung cancer induction is commonly regarded as the most important somatic risk arising from the inhalation of radon and its decay products. Relating carcinogenesis to radiation exposure needs a detailed knowledge of the cellular dose distribution in the human respiratory tract. Different dosimetric models have been developed for the determination of cellular doses, particularly for the basal cells of the bronchial epithelium which are considered as the critical cells for lung cancer induction. Part 1 of the paper describes the influence of various environmental as well as anatomical and physiological factors on the resulting dose. Significant inter- as well as intra-subject variabilities of structural components of the human lung, respiration characteristics and clearance mechanisms demonstrate the necessity of applying stochastic models in lung dosimetry.
mesh_terms: D000293:Adolescent; D000328:Adult; D001729:Bismuth; D002648:Child; D002675:Child, Preschool; D002923:Cilia / Q000502:physiology; D003043:Cocarcinogenesis; D006801:Humans; D006813:Humidity; D007854:Lead; D008175:Lung Neoplasms / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D011059:Polonium; D011829:Radiation Dosage; D017687:Radon Daughters; D012119:Respiration; D012306:Risk
chemical_list: D017687:Radon Daughters; D007854:Lead; D011059:Polonium; D001729:Bismuth