A new tumor-promoting agent, dihydroteleocidin B, markedly enhances chemically induced malignant cell transformation.
Teleocidin, which was isolated from mycelia of Streptomyces, is a potent tumor promoter in mouse skin. The catalytically hydrogenated compound dihydroteleocidin B markedly enhanced malignant cell transformation induced by 3-methylcholanthrene or ultraviolet radiation. Dihydroteleocidin B was at least 100 times more effective in enhancing transformation than 12-O-tetradecanoyl phorbol-13-acetate, the strongest promoter known until now, whereas both promoters showed equal capacities to induce early membrane effects and DNA synthesis.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors; D008235:Lyngbya Toxins; D008748:Methylcholanthrene; D051379:Mice; D011956:Receptors, Cell Surface / Q000378:metabolism
D000470:Alkaloids; D002273:Carcinogens; D008235:Lyngbya Toxins; D011956:Receptors, Cell Surface; D008748:Methylcholanthrene; D004815:Epidermal Growth Factor; C022229:dihydroteleocidin B; D066246:ErbB Receptors