Bioassays in modern peptide research.
Bioassays have been used in pharmacology since its beginning, nearly one hundred years ago. With the recent development of new techniques such as radioreceptor assays, radioimmunoassays, high pressure liquid chromatography (HPLC) and recombinant DNA technology, it might be asked if bioassays are still up-to-date in a fast moving field like peptide research? This brief review describes the possible uses of bioassays as well as the basic criteria used to characterize a bioassay. Recent results obtained with bioassays for various peptides will demonstrate the importance of this technique in modern peptide research.
D000818:Animals; D001665:Binding Sites; D001681:Biological Assay / Q000379:methods*; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D009496:Neurotensin / Q000032:analysis; D010455:Peptides / Q000032:analysis*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism
D010455:Peptides; D011956:Receptors, Cell Surface; D009496:Neurotensin