The increase of cerebellar cAMP level after decapitation: the effect of propranolol.
The increase of cAMP level of the rat cerebellum induced by decapitation was studied. Administration of 5 mg/100 g propranolol 1 hour before decapitation completely prevented this increase. Neither the depletion of catecholamine pools, inhibition of their synthesis, nor barbiturate treatment influenced the increase of cAMP level evoked by decapitation. It has been concluded that noradrenergic neurotransmission is involved in the cerebellar cAMP level increase after decapitation.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats
D011433:Propranolol; D000242:Cyclic AMP