[Role of cAMP in regulating the shape of thrombocytes].
Preincubation of platelet suspension with dbcAMP during 2 minutes inhibited the ADP-induced change in platelet shape. An increase of the cAMP content in the cell induced by papaverine inhibiting phosphodiesterase also blocked the change in the shape caused by ADP and prostaglandin E2 (PGE2). Incubation of platelets in medium with pH 9.0 or addition of PGE2 produced a stable change in the shape of the cells. The action of dbcAMP or papaverine on the changed cells accelerated the recovery of the native shape and the content of membrane-bound calcium.
D000818:Animals; D001792:Blood Platelets / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology*; D051381:Rats; D013050:Spectrometry, Fluorescence
D000242:Cyclic AMP
Rol' tsAMF v reguliatsii formy trombotsitov.