[Structural and functional characteristics of the sarcoplasmic reticulum membranes of the skeletal muscles in thyrotoxicosis].
A rate of CA2+ accumulation and efficiency of Ca2+-pump were decreased in the fractions of skeletal muscle sarcoplasmic reticulum isolated from rabbits with thyrotoxicosis. Temperature of phase transition in membranes of sarcoplasmic reticulum was changed by 4-5 degrees towards low temperatures. Under conditions of thyrotoxicosis fatty acid composition of total lipids from the sarcoplasmic reticulum fractions was altered as follows: amount of palmitic acid was increased 1.4-fold but oleic and arachidonic acids were decreased 21.8% and 40.5%, respectively. Modification of Ca2+-transport properties in sarcoplasmic reticulum caused by long-term administration of thyroid hormones into animals appears to alter the membrane protein-lipid composition.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002849:Chromatography, Gas; D004578:Electron Spin Resonance Spectroscopy; D005227:Fatty Acids / Q000032:analysis; D006980:Hyperthyroidism / Q000378:metabolism / Q000473:pathology*; D007425:Intracellular Membranes / Q000378:metabolism / Q000648:ultrastructure*; D007473:Ion Channels / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D009132:Muscles / Q000378:metabolism / Q000648:ultrastructure*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000378:metabolism / Q000648:ultrastructure*
D005227:Fatty Acids; D007473:Ion Channels; D002118:Calcium
Strukturno-funktsional'nye osobennosti membran sarkoplazmaticheskogo retikuluma skeletnykh myshts pri tireotoksikoze.