On the changes of the time course of the end-plate current during repetitive stimulation.
In a previous study it was observed that prolonged repetitive stimulation (10.s-1) markedly lengthened the time course of the end-plate current. In order to investigate whether this effect could be due to a more dispersed release of the mediator or to a decreased clearance of the mediator from the synaptic cleft, the rise time of the end-plate current and of the miniature end-plate current were analyzed. The results show that presynaptic factors may be involved.
D000818:Animals; D004553:Electric Conductivity; D004558:Electric Stimulation; D009045:Motor Endplate / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology*; D011893:Rana esculenta; D009435:Synaptic Transmission; D013997:Time Factors