[Pathogenesis of the arterial hypertensive syndrome in Itsenko-Cushing disease].
The indices of central hemodynamics and renin-angiotensine-aldosterone system, as well as their relationship, were studied in patients with aggravated Icenko-Cushing's disease. A stable high arterial pressure, a raised total peripheral resistance, a decreased cardiac index, an increased blood corticotrophin, cortisol and aldosterone levels and an enhanced plasmatic renin activity were revealed. It is suggested that activation of the renin-angiotensin-aldosterone system stimulates the development of arterial hypertension in patients with Icenko-Cushing's disease, taking into account a significant role of this system in alteration of the central hemodynamics indices.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D003480:Cushing Syndrome / Q000150:complications* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System
D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D012083:Renin
O patogeneze gipertenzivnogo arterial'nogo sindroma pri bolezni Itsenko-Kushinga.