Molecular size of different neurotoxin receptors on the voltage-sensitive Na+ channel.
Measurements were made of the molecular sizes of two distinct receptors on the Na+ channel in rat brain synaptosomes that are specific for different neurotoxins. Radiation inactivation of the binding of radiolabeled derivatives of the toxins was consistent with Mr = 260,000 for the tetrodotoxin receptor and Mr = 266,000 for the receptor specific for two scorpion toxins, toxin II from Centruroides suffusus suffusus and toxin gamma from Tityus serrulatus serrulatus. Covalent cross-linking of the latter to its receptor similarly indicated Mr = 270,000. It seems most likely that these two distinct receptors reside on the same molecule.
D029845:Amphibian Proteins; D000818:Animals; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000032:analysis*; D007473:Ion Channels / Q000378:metabolism*; D008970:Molecular Weight; D051381:Rats; D012604:Scorpion Venoms / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels; D013574:Synaptosomes / Q000378:metabolism
D029845:Amphibian Proteins; D002352:Carrier Proteins; D007473:Ion Channels; D012604:Scorpion Venoms; D015222:Sodium Channels; C027525:saxitoxin-binding protein, Rana catesbeiana; C023790:tetrodotoxin-binding protein; D012964:Sodium