A novel leukotriene produced by stimulation of leukocytes with formylmethionylleucylphenylalanine.
Stimulation of human polymorphonuclear leukocytes with the chemotactic peptide formylmethionylleucylphenylalanine led to the formation of a novel leukotriene: 5(S),12(R)-dihydroxy-6,8,10,14-eicosatetraen-1,20-dioic acid. This dihydroxydicarboxylic acid is derived from omega-oxidation of 5(S),12(R),dihydroxy-6,8,10,14-eicosatetradienoic acid (leukotriene B4). The intermediate 5(S),12(R),20-trihydroxy-6,8,10,14-eicosatetraenoic acid was also isolated from these incubations. The two metabolites of leukotriene B4 exhibit chemotactic properties for human polymorphonuclear leukocytes but are less active in this respect than the parent compound.
D001095:Arachidonic Acids / Q000096:biosynthesis* / Q000097:blood / Q000302:isolation & purification; D002465:Cell Movement; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D007975:Leukotriene B4; D013058:Mass Spectrometry; D008715:Methionine / Q000031:analogs & derivatives*; D009239:N-Formylmethionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D001095:Arachidonic Acids; D009842:Oligopeptides; D007975:Leukotriene B4; D009239:N-Formylmethionine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008715:Methionine