[Theoretical description of the calcium channel in the spinal ganglion neurons of the rat].
The surface charge density (sigma'0 and the constant of Ca2+ binding with the charged surface groups of the outer side of the membrane (KCa) are calculated on the basis of experimentally determined values of the current-voltage characteristic shifts for calcium currents in the membrane of rat spinal ganglia neurons. The obtained values are as follows: sigma'0 = 0.15 +/- 0.05 e/nm2 and KCa = 70 +/- 10 1/ml. The energy profile of the calcium channel in the membrane of investigated neurons was calculated for Ca2+, Ba2+ Cd2+ Mn2+ Co2+ ions and verapamil using a three-barrier model. It is shown that the value of calcium current is determined mainly by the potential hole depth which corresponds to the outer binding centre of the calcium channel. On the basis of the data obtained a conclusion is made that the outer binding centre contains only one carboxylic group.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002413:Cations, Divalent / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D008433:Mathematics; D008564:Membrane Potentials; D008959:Models, Neurological; D051381:Rats; D014700:Verapamil / Q000378:metabolism
D002413:Cations, Divalent; D007473:Ion Channels; D014700:Verapamil; D002118:Calcium
Teoreticheskoe opisanie kal'tsievogo kanala v neĭronakh spinal'nykh gangliev krys.