Chronic propranolol treatment decreases cardiac beta-adrenoceptors in spontaneously hypertensive rats.
Spontaneously hypertensive (SHR) rats were treated for 6 months with 41.6 or 94.6 mg/kg per day of (+/-)-propranolol. Compared to untreated SHR rats, the heart rate and blood pressure in both treated groups were decreased. The cardiac beta-adrenoceptor concentration was similar in the untreated and low dose (+/-)-propranolol-treated group but was decreased by 30% after treatment with the high (+/-)-propranolol dose. The results suggest that high dose (+/-)-propranolol treatment reduces the cardiac beta-adrenoceptor concentration.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004082:Dihydroalprenolol; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D011433:Propranolol