Carcinogenicity in rats of the mutagenic compounds 1-nitropyrene and 3-nitrofluoranthene.
1-Nitropyrene and 3-nitrofluoranthene are present in diesel exhaust, in pollutants in air, and were also present in certain xerographic toners and copies. Their carcinogenicities were studied in male F344/DuCrj rats by subcutaneous injection. Sarcomas, mainly malignant fibrous histiocytomas at the site of injection were induced in 8 to 17 (47%) rats by 1-nitropyrene and in 4 of 10 (40%) rats by 3-nitrofluoranthene. Some tumors were serially transplantable in the same strain of rats.
D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002274:Carcinogens, Environmental / Q000633:toxicity; D005449:Fluorenes / Q000633:toxicity*; D018219:Histiocytoma, Benign Fibrous / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009368:Neoplasm Transplantation; D011721:Pyrenes / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012509:Sarcoma / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D000393:Air Pollutants; D002274:Carcinogens, Environmental; D005449:Fluorenes; D011721:Pyrenes; C033643:3-nitrofluoranthene; C032668:1-nitropyrene