Inhibition of the release of virion-associated murine leukemia virus genomic RNA by vesicular stomatitis virus.
The genomic RNAs of murine leukemia virus (MuLV) and vesicular stomatitis virus (VSV) were distinguishable based on a difference in sedimentation coefficient, polyadenylic acid content, and nucleotide sequence homology. Applying these biochemical characteristics, we found that the release of virion-associated MuLV genomic RNA from virus-producing cells was inhibited by VSV as early as 2 h after superinfection. This finding offers an explanation to our previous inability to detect MuLV(VSV) pseudotype formation during mixed infection with VSV and MuLV.
D000225:Adenine / Q000032:analysis; D000818:Animals; D001482:Base Composition; D002460:Cell Line; D002499:Centrifugation, Density Gradient; D007700:Kinetics; D009052:Leukemia Virus, Murine; D051379:Mice; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000378:metabolism*; D014721:Vesicular stomatitis Indiana virus / Q000235:genetics*; D014762:Viral Interference; D014779:Virus Replication; D014780:Viruses / Q000235:genetics*
D012367:RNA, Viral; D000225:Adenine