Effect of methaqualone on plasma corticosterone in rats: possible sites of action.
Methaqualone produces large increases in plasma corticosterone in rats. This effect does not involve a direct stimulation of either the adrenal glands or pituitary, nor is it the result of a significant alteration in the clearance of circulating corticosterone. Methaqualone may therefore be influencing brain mechanisms which ultimately regulate hypothalamic CRH secretion, although a peripheral site of action has not yet been ruled out.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008702:Methaqualone / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D008702:Methaqualone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone