title: [Determination of hepatitis A virus in the feces of patients in the dynamics of the infectious process].
abstract: Excretion of hepatitis A virus (HAV) in the time course of the infectious process is described. Among 197 fecal specimens collected from 45 patients HAV was found in 40 (20.5%); in 51% of the patients the virus was isolated in the 1st week of the icteric period, in 25% in the 2nd week and in 4% in the 3rd week. The buoyant density in cesium chloride gradient of virus specimens obtained on the 1st-2nd day of jaundice was represented by one peak of 1.30-1.35 g/cm3, whereas the material collected at late periods of the disease had heterogeneous buoyant density in zones from 1.24 to 1.43 g/cm3. The immune electron microscopic studies showed the fecal specimens collected early in the disease to be richer in virus than those collected at later intervals.
mesh_terms: D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000382:microbiology*; D006506:Hepatitis A / Q000382:microbiology*; D006507:Hepatovirus / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007565:Jaundice / Q000382:microbiology; D013997:Time Factors
chemical_list: D000956:Antigens, Viral
vernacular_title: Opredelenie virusa gepatitia A v fekaliiakh bol'nykh v dinamike infektsionnogo protsessa.