Role of cyclic AMP in the inhibition of human platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin.
Quercetin (3.3',4',5,7-pentahydroxyflavone) has previously been shown to inhibit cyclic nucleotide phosphodiesterases prepared from various cell homogenates and the function of intact human platelets. We now report that (1) high concentrations of quercetin raise platelet cAMP levels; and (2) quercetin potentiates the inhibitory effect of prostacyclin (PGI2) on ADP-induced washed human platelet aggregation and the elevation of platelet cAMP levels elicited by PGI2. These results suggest a role for cAMP in the mechanism of action of quercetin on blood platelets.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood / Q000502:physiology*; D004357:Drug Synergism; D011464:Epoprostenol / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology*; D013997:Time Factors
D005419:Flavonoids; D011453:Prostaglandins; D000244:Adenosine Diphosphate; D011794:Quercetin; D011464:Epoprostenol; D000242:Cyclic AMP