Strain differences in opiate receptors in mouse brain.
Various opiate ligands were bound to brain membranes of mice of the Recombinant Inbred System. The specific binding of low levels of [3H]naloxone, [3H]dihydromorphine and [3H]ethylketocyclazocine was disturbed in a similar fashion among the inbred strains, and in a pattern different from that observed for [3H](D-Ala2,D-Leu5)-enkephalin. The results indicate that the inbred strains differ in mu- and delta-type binding and support the concept of multiple opiate receptors in mouse brain.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003496:Cyclazocine / Q000031:analogs & derivatives / Q000378:metabolism; D004090:Dihydromorphine / Q000378:metabolism; D016308:Enkephalin, Leucine-2-Alanine; D004745:Enkephalins / Q000378:metabolism; D016314:Ethylketocyclazocine; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009270:Naloxone / Q000378:metabolism; D011957:Receptors, Opioid / Q000187:drug effects*; D013045:Species Specificity
D004745:Enkephalins; D011957:Receptors, Opioid; D009270:Naloxone; D016314:Ethylketocyclazocine; D016308:Enkephalin, Leucine-2-Alanine; D004090:Dihydromorphine; D003496:Cyclazocine