Stimulation of sporulation of Clostridium perfringens by papaverine.
Papaverine induced sporulation in Clostridium perfringens, strains FD-1 and PS52; growth was markedly slowed under these conditions. Papaverine induced sporulation in the presence of glucose, a sporulation repressor, although increasing glucose concentrations overcame the papaverine effect. Papaverine induced sporulation of strain FD-1 more effectively than did theophylline.
D002455:Cell Division / Q000187:drug effects; D003016:Clostridium perfringens / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology*; D013171:Spores, Bacterial; D013806:Theophylline / Q000494:pharmacology
D013806:Theophylline; D010208:Papaverine; D005947:Glucose