title: [Contribution of brain and liver to the biosynthesis of cholesterol during the postnatal development of the chicken].
abstract: The high content of esterified cholesterol found in neonatal chick liver seems to be transferred from the yolk and decreases throughout the yolk sac regression, increasing at the same time the percentage of free cholesterol newly synthesized. In brain, there are no significant changes in cholesterol content during postnatal development, being predominant the free cholesterol synthesized during myelination. Changes in the hepatic HMG-CoA reductase activity are similar to those found in the acetate incorporation into nonsaponifiable lipids and are in agreement with the inhibition of cholesterogenesis during the first days after hatching and its activation with the decrease of esterified cholesterol. Chick liver PPMVA decarboxylase shows similar changes, suggesting an important role for this enzyme in the hepatic cholesterol synthesis. Only scant variations are exhibited by the MVA-activating enzymes. Brain enzymes do not change significantly throughout postnatal development.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002262:Carboxy-Lyases / Q000378:metabolism; D002645:Chickens / Q000254:growth & development / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis*; D002788:Cholesterol Esters / Q000378:metabolism; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010770:Phosphotransferases / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor); D017856:Phosphotransferases (Phosphate Group Acceptor)
chemical_list: D002788:Cholesterol Esters; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C021796:mevalonate kinase; D017856:Phosphotransferases (Phosphate Group Acceptor); C022371:phosphomevalonate kinase; D002262:Carboxy-Lyases; C022503:pyrophosphomevalonate decarboxylase
vernacular_title: Contribución del cerebro y del hígado a la biosíntesis del colesterol durante el desarrollo postnatal del pollo.