Vitamin D stimulates (Na+ + K+)-ATPase activity in chick small intestine.
Vitamin D3 and 1,25-dihydroxyvitamin D3 raise (Na+ + K+)-ATPase activity (ouabain-sensitive 86Rb+ uptake) in cultured embryonic and 4-week-old chick small intestine. Vitamin D stimulation of the sodium pump, which requires genomic action of the sterol, may lead to enhanced Ca2+ extrusion via a basolateral Na+/Ca2+ exchange mechanism, and, in addition, may provide a proliferative signal in undifferentiated enterocytes.
D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D002642:Chick Embryo; D002645:Chickens; D002762:Cholecalciferol / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology; D007421:Intestine, Small / Q000196:embryology / Q000201:enzymology*; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D009924:Organ Culture Techniques; D011868:Radioisotopes; D012413:Rubidium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D007473:Ion Channels; D011868:Radioisotopes; D002762:Cholecalciferol; D003609:Dactinomycin; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D002117:Calcitriol; D012413:Rubidium