Synthesis and characterization of iodoazidobenzylpindolol.
A high affinity beta-adrenergic ligand, iodoazidobenzylpindolol, was synthesized and characterized. The absorption spectrum of this compound changed markedly upon photolysis, consistent with decomposition of the azide group. This compound has a KD of 5--7 x 10(-10) M for the duck erythrocyte ghost beta-adrenergic receptor when measured in a competitive binding assay.
D000345:Affinity Labels / Q000138:chemical synthesis*; D000818:Animals; D001386:Azides; D001667:Binding, Competitive; D004372:Ducks; D004912:Erythrocytes / Q000378:metabolism; D066298:In Vitro Techniques; D010869:Pindolol / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
D000345:Affinity Labels; D001386:Azides; D011943:Receptors, Adrenergic, beta; C029987:1-(indol-4-yloxy)-3-(1-(4-azido-3-iodophenyl)-2-isobutylamine)-2-propanol; D010869:Pindolol