beta-Endorphin: isolation, amino acid sequence and synthesis of the hormone from horse pituitary glands.
Beta-endorphin has been isolated from equine pituitaries. Its amino acid sequence is identical to that of ovine, bovine and camel beta-endorphins except for substitution of the threonine residue at position 6 by serine. The equine beta-endorphin has also been synthesized by the solid-phase method. In comparison with the human hormone, equine beta-endorphin was shown to possess 3 times the receptor-binding activity in rat membrane preparations and 1.6 times the analgesic potency in the mouse tail-flick assay.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000700:Analgesics; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography; D004723:Endorphins / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D006736:Horses / Q000378:metabolism*; D010902:Pituitary Gland / Q000032:analysis*; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism; D001615:beta-Endorphin
D000596:Amino Acids; D000700:Analgesics; D004723:Endorphins; D011957:Receptors, Opioid; D001615:beta-Endorphin