1,25-dihydroxyvitamin D3 and the regulation of macrophage function.
Vitamin D3 deficient (D-) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D- mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D- mice can be corrected by incubation with 1,25-dihydroxyvitamin D3 and is not affected by interaction with other vitamin D3 metabolites. Transfer of mice from the D- to the D+ state results in correction of both the inflammatory and the phagocytic response. Intactness of phagocyte function is thus directly dependent on vitamin D3 metabolism.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D001854:Bone Marrow Cells; D002117:Calcitriol / Q000494:pharmacology*; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D002762:Cholecalciferol / Q000172:deficiency*; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D013864:Thioglycolates; D014808:Vitamin D Deficiency / Q000276:immunology*
D013864:Thioglycolates; D002762:Cholecalciferol; D002117:Calcitriol