Reduced [3H]-tetrodotoxin binding in the napts paralytic mutant of Drosophila.
The temperature-sensitive paralytic mutant of Drosophila, napts, has been shown to have defects in axonal physiology which suggest that it codes for a component of the voltage-sensitive sodium channel. Ligand binding studies using tritiated tetrodotoxin, a sodium channel antagonist, show a decrease in the apparent number of sodium channels in napts, providing additional support for this hypothesis.
D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism; D006358:Hot Temperature; D007473:Ion Channels / Q000378:metabolism; D009154:Mutation; D009474:Neurons / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013779:Tetrodotoxin / Q000378:metabolism*
D007473:Ion Channels; D013779:Tetrodotoxin; D012964:Sodium