title: Clonidine withdrawal: activation of brain noradrenergic neurons with specifically reduced alpha 2-receptor sensitivity.
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D003000:Clonidine / Q000009:adverse effects*; D004594:Electrophysiology; D006801:Humans; D007478:Iontophoresis; D008125:Locus Coeruleus / Q000503:physiopathology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D011942:Receptors, Adrenergic, alpha; D011957:Receptors, Opioid; D009020:Morphine; D003000:Clonidine; D009638:Norepinephrine