Cyclic GMP in the human erythrocyte. Intracellular levels and transport in normal subjects and chronic hemodialysis patients.
We have studied the intracellular levels of cyclic GMP in the red blood cells of chronic hemodialysis patients before and after dialysis treatment and in normal subjects. Cyclic GMP is present at levels (mean +/- 1SD) of 19.6 +/- 4.7 and 18.4 +/- 5.8 nM/L before and after treatment, respectively. The levels in normal subjects are 3.6 +/- 0.9. The uptake of cyclic GMP was also studied and the data demonstrate that the red blood cell is slightly permeable to cyclic GMP, suggesting that cyclic GMP uptake could substitute for guanylate cyclase activity in the human erythrocyte.
D001692:Biological Transport; D002463:Cell Membrane Permeability; D006152:Cyclic GMP / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D006435:Renal Dialysis
D006152:Cyclic GMP