Gastric acid secretion using pentagastrin: dose-response studies.
The results of gastric stimulation using varying doses of pentagastrin in twenty-five Nigerians (twenty cases of duodenal ulcer and five controls) are presented. Doses used were 4, 6, 8, and 10 micrograms/kg bodyweight. The optimal response was obtained using 6 micrograms/kg bodyweight in the test cases while the maximum acid output (MAO) was 15.14 mEq/hr (19 mEq/hr in males, 12.50 mEq/hr in females). The recommended dose for optimal response in Caucasians is 6 micrograms/kg bodyweight which correlates with the dose in our patients. However, the maximum acid output at this dose is higher in Caucasians.
D000328:Adult; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000188:drug therapy; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin
D010418:Pentagastrin