A comparison of superoxide production by human eosinophils and neutrophils.
Previous studies have demonstrated that human eosinophils have a more active hexose monophosphate shunt than neutrophils. However, measurements of superoxide anion production have been variable. In this study human eosinophils are shown to produce one and a half times as much superoxide as neutrophils during a 2-h incubation. The rates of production differed only after the first 30 min of incubation. The production was inhibited by superoxide dismutase in a dose-responsive manner.
D003574:Cytochrome c Group / Q000378:metabolism; D004804:Eosinophils / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000096:biosynthesis*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000096:biosynthesis*; D013997:Time Factors; D015054:Zymosan / Q000494:pharmacology
D003574:Cytochrome c Group; D013481:Superoxides; D015054:Zymosan; D013482:Superoxide Dismutase; D010100:Oxygen