title: Interference of Salivary immunoglobulin A antibodies and other salivary fractions with adherence of Streptococcus mutans to hydroxyapatite.
abstract: The adherence of Streptococcus mutans to hydroxyapatite was studied in the presence of salivary fractions with varying activity of naturally occurring immunoglobulin A (IgA) antibodies. Human parotid saliva from different donors was fractionated by chromatography and compared. Salivary IgA antibodies had no decisive effect on the adherence of the S. mutans strain used. High-molecular-weight salivary components from some subjects had an adherence-promoting effect, whereas fractions collected after the void volume of a Sepharose 2B column always inhibited adherence. The data indicate that the influence of unfractionated saliva on adherence is dependent on the net effect of adherence-promoting and adherence-inhibiting components. This principle has to be considered when the effect of human saliva on microbial adherence is studied.
mesh_terms: D000268:Adhesiveness; D000888:Antibodies, Anti-Idiotypic / Q000502:physiology*; D001667:Binding, Competitive; D002850:Chromatography, Gel; D017886:Durapatite; D005260:Female; D006801:Humans; D006882:Hydroxyapatites / Q000378:metabolism; D007070:Immunoglobulin A / Q000378:metabolism*; D008297:Male; D012463:Saliva / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D006882:Hydroxyapatites; D007070:Immunoglobulin A; D017886:Durapatite