Comparison between two radiation protective substances in irradiated mice. Effect on splenic haemopoiesis.
The radiation protective action of 2,2'-Dithiobis(N-[(1-adamantyl)-methyl]-acetamidine)-dihyrochloride (S-75) and cysteamine was compared in splenectomized and non-splenectomized mice. Cysteamine was found to have better and more general protection properties. Several indications of a specific effect of S-75 on the spleen were observed. It is suggested that the protection properties of S-75 should be tested in another laboratory animal not having such a marked splenic haemopoiesis as the mouse.
D000081:Acetamides / Q000494:pharmacology*; D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D003543:Cysteamine / Q000494:pharmacology*; D006410:Hematopoiesis / Q000528:radiation effects*; D006470:Hemorrhage / Q000209:etiology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000528:radiation effects*; D013156:Splenectomy; D013853:Thioacetamide / Q000031:analogs & derivatives / Q000494:pharmacology*
D000081:Acetamides; D011837:Radiation-Protective Agents; D013853:Thioacetamide; C017267:2,2-dithiobis(N-(1-adamantyl)methyl)acetamide; D003543:Cysteamine; D000218:Adamantane