Naloxone and self-mutilation.
A 15-year-old male with a long history of self-mutilation resembling the Lesch-Nyhan syndrome, but with normal uric acid levels, was treated with naloxone. Pain-inducing behavior decreased in the evenings following infusion of the drug, and was markedly reduced for 2 days following the treatment period. Though not recommended as therapy, the observations suggest that naloxone may play a role in the regulation of endorphin/enkephalin neural systems.
D000293:Adolescent; D006801:Humans; D008297:Male; D009270:Naloxone / Q000627:therapeutic use*; D011957:Receptors, Opioid / Q000187:drug effects; D012652:Self Mutilation / Q000188:drug therapy* / Q000523:psychology
D011957:Receptors, Opioid; D009270:Naloxone