[Trigger function of cyclic AMP in the initiation of HCl secretion by the frog gastric mucosa].
Histamine (0.3 mM) caused a rapid but transient increase in cAMP level prior to a rise in HCl secretion in the isolated gastric mucosa of frog Rana esculenta. H2-receptor blocking agent cimetidine (0.01 mM) suppressed HCl secretion which had been preceded by a decrease in cAMP level. No statistically significant changes in cGMP content were found. Dibutyryl cAMP imitated the effect of histamine. In frogs captured in spring, with a high level of HCl secretion and high content of cAMP, histamine exerted no stimulating effect. It seems to be the cAMP and not cGMP that acts either as a trigger in activation of HCl secretion or as a stabilizer of induced secretion.
D000818:Animals; D001001:Anura; D003994:Bucladesine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D000242:Cyclic AMP / Q000032:analysis / Q000502:physiology*; D006152:Cyclic GMP / Q000032:analysis; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000032:analysis / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D012621:Seasons; D013268:Stimulation, Chemical
D003995:Dibutyryl Cyclic GMP; D003994:Bucladesine; D002927:Cimetidine; D006632:Histamine; D000242:Cyclic AMP; D006152:Cyclic GMP
Triggernaia funktsiia tsiklicheskogo AMF v initsiatsii sekretsii HCl slizistoĭ obolochkoĭ zheludka liagushki.