Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.
D000496:Alloxan / Q000494:pharmacology*; D000577:Amides / Q000494:pharmacology; D000818:Animals; D004247:DNA / Q000378:metabolism*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D009243:NAD / Q000378:metabolism; D009244:NAD+ Nucleosidase / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D010848:Picolinic Acids / Q000494:pharmacology; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011384:Proinsulin / Q000096:biosynthesis; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology*
D000577:Amides; D010848:Picolinic Acids; D009243:NAD; D009536:Niacinamide; D013311:Streptozocin; D000496:Alloxan; D004247:DNA; D011384:Proinsulin; D011065:Poly(ADP-ribose) Polymerases; D009244:NAD+ Nucleosidase; C003142:picolinamide