title: Highly variable regions of DNA flank the human alpha globin genes.
abstract: A series of restriction fragment length polymorphisms which are due to DNA rearrangements have been identified within two highly variable regions flanking the human alpha globin genes. The existence of such highly polymorphic areas provides a large number of individual genetic markers for the alpha globin gene cluster on chromosome 16. If, as seems likely, such regions occur frequently throughout the human genome they should be of considerable value in the antenatal diagnosis of genetic disease.
mesh_terms: D002902:Chromosomes, Human, 16-18; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes / Q000378:metabolism; D015245:Deoxyribonuclease BamHI; D015252:Deoxyribonucleases, Type II Site-Specific; D005819:Genetic Markers; D005914:Globins / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D013789:Thalassemia / Q000235:genetics
chemical_list: D005819:Genetic Markers; D005914:Globins; D004247:DNA; D004262:DNA Restriction Enzymes; D015245:Deoxyribonuclease BamHI; D015252:Deoxyribonucleases, Type II Site-Specific; C018492:GCCNNNNNGGC-specific type II deoxyribonucleases