title: Effect of conjugated estrogens on vaginal blood flow in surgically menopausal women.
abstract: The effect of an intravenous bolus of 25 mg of conjugated estrogen (Premarin) on vaginal blood flow in seven surgically menopausal women was measured by a thermal conductance probe. Electrical power (0.8 W) was supplied to a resistance wire incorporated in the surface of the probe, and its surface temperature was monitored continuously for 30 minutes six times daily for 3 days. The mean temperature difference (delta T) between the heated probe surface and the vagina remained unchanged during a preinjection control day. While there were individual differences in response, analysis of mean delta T during the first day following the injection of the estrogen revealed a significant linear downward trend at delta T, indicating a rise in vaginal blood flow. Delta T plateaued on day 2 and showed a slight rise in the morning of day 3. It may be concluded that estrogen administered in this dose and form markedly increases vaginal blood flow.
mesh_terms: D000328:Adult; D001831:Body Temperature; D002369:Castration; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008593:Menopause; D012039:Regional Blood Flow / Q000187:drug effects; D013814:Thermal Conductivity; D014621:Vagina / Q000098:blood supply*
chemical_list: D004966:Estrogens, Conjugated (USP)