Hypertension through adrenaline activation of prejunctional beta-adrenoceptors.
1. Adrenaline can enhance the stimulation-induced release of transmitter noradrenaline in sympathetically innervated tissues by activating prejunctional beta-adrenoceptors. 2. Adrenaline incorporated into sympathetic transmitter stores by neuronal uptake can be subsequently released as a co-transmitter and can then activate prejunctional beta-adrenoceptors, thus completing a facilitatory feedback loop. 3. Rats chronically treated with adrenaline develop elevated blood pressures compared to control rats. beta-Adrenoceptor blockade prevents the rise in blood pressure. 4. Activation by adrenaline of facilitatory prejunctional beta-adrenoceptors of sympathetic nerves innervating cardiovascular effector tissues may explain adrenaline-induced rises in blood pressure.
D000313:Adrenal Medulla / Q000378:metabolism; D000818:Animals; D004837:Epinephrine / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000662:veterinary; D007365:Intercellular Junctions / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004837:Epinephrine