Herpes simplex vaccine using cell membrane associated antigen in an animal model.
Vesicles of plasma membrane, containing no detectable live virus, were prepared by treatment of Herpes simplex virus type 2 (HSV-2) infected Vero cells with dithiothreitol and formaldehyde. These preparations proved to be antigenic on injection into guinea-pigs and also protected these animals against intravaginal challenge with HSV-2.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D000956:Antigens, Viral / Q000302:isolation & purification; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D002472:Cell Transformation, Viral; D002522:Chlorocebus aethiops; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney; D018139:Simplexvirus / Q000276:immunology*; D014765:Viral Vaccines
D000956:Antigens, Viral; D014765:Viral Vaccines