title: Na+/K+ ATPase and cell growth: effect of epidermal growth factor on the enzymatic activity in chick embryo epidermis during the embryonal development.
abstract: 1. The behaviour of ATPase activity during embryonic development of chick embryo epidermis has been studied in the absence or presence of a single inoculation of EGF at the fifth day from fertilization (0-day). 2. EGF strongly decreases ATPase activity by affecting Na+/K+ ATPase. This effect occurs only if begun at 0-day. 3. This effect is due to the EGF induced decrease of -SH groups that are active part of Na+/K+ ATPase.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D000078404:Epidermal Cells; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004817:Epidermis / Q000196:embryology / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D013438:Sulfhydryl Compounds; D004815:Epidermal Growth Factor; D000254:Sodium-Potassium-Exchanging ATPase