Inhibition of basal and stimulated gastric acid secretion by an enkephalin analogue.
The effect of a synthetic enkephalin analogue (Sandoz FF33-824: DAMME) on basal and submaximally stimulated gastric acid secretion was investigated in six healthy hypersecretors. Basal acid secretion was markedly inhibited by the enkephalin analogue. When gastric secretion was stimulated by a continuous intravenous infusion of 100 ng/kg/h of pentagastrin the enkephalin analogue reduced acid output by 50%. Intravenous naloxone reversed the subjective effects of the enkephalin analogue but did not reverse the inhibitory effect on basal and stimulated acid secretion.
D000328:Adult; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D003864:Depression, Chemical; D004723:Endorphins / Q000494:pharmacology*; D004745:Enkephalins / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D011957:Receptors, Opioid / Q000502:physiology; D013997:Time Factors
D004723:Endorphins; D004745:Enkephalins; D011957:Receptors, Opioid; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D010418:Pentagastrin