title: Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance.
abstract: The voltage dependence of the conductance induced induced in thin lipid membranes by monazomycin is shown here to be caused by voltage-dependent variations in the frequency of channel openings. We also experimentally demonstrate certain interesting properties of the channel activity that are predicted by a chemical kinetic model (Muller and Peskin, 1981), which successfully describes the macroscopic conductance. We conclude that two parallel mechanisms--one autocatalytic, the other simple mass action--exist that allow monazomycin to enter (or leave) the membrane so that the monazomycin molecules can be in a position to form channels.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004553:Electric Conductivity; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D008051:Lipid Bilayers; D018942:Macrolides; D008564:Membrane Potentials; D008956:Models, Chemical; D011090:Polyenes / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D007473:Ion Channels; D008051:Lipid Bilayers; D018942:Macrolides; D011090:Polyenes; C005240:monazomycin