Treatment of chromomycosis with ketoconazole and 5-fluorocytosine.
Chromomycosis is a disfiguring cutaneous mycosis that is often recalcitrant to therapy. We describe a case of chromomycosis of the lower extremities that is being successfully treated with ketoconazole and 5-fluorocytosine (5-FC) after treatment with ketoconazole alone had failed. In vitro studies showed that the drugs acted synergistically against the strain of Fonsecaea pedrosoi which was isolated from the patient's lesion.
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D002862:Chromoblastomycosis / Q000188:drug therapy* / Q000473:pathology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D007654:Ketoconazole; D008297:Male; D010879:Piperazines / Q000008:administration & dosage*; D012867:Skin / Q000473:pathology
D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D007654:Ketoconazole