Responses to cafeteria feeding in mice after the removal of interscapular brown adipose tissue.
Feeding a cafeteria diet to mice resulted in an increased energy intake of approximately 30% and this led to increases in the wet weight, total protein content, and total cytochrome oxidase activity of interscapular and dorso-cervical brown adipose tissue. Surgical removal of interscapular brown adipose tissue, followed by cafeteria feeding, gave rise to an elevation in dorso-cervical brown adipose tissue wet weight, total protein content, and total cytochrome oxidase activity, compared to intact cafeteria-fed mice. Cafeteria feeding with or without the removal of interscapular brown adipose tissue did not lead to significant increases in body weight compared to stock-fed control mice, but both cafeteria-fed groups of mice showed significant elevations in body fat content indicating that the induced hyperphagia led to a relative obesity in the cafeteria-fed groups. The results presented are consistent with an increased thermogenic activity in the brown adipose tissue of cafeteria-fed mice, and the effect of the removal of interscapular brown adipose tissue further indicates the quantitative importance of the tissue in the control of body weight.
D002001:Adipose Tissue, Brown / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D004032:Diet; D004044:Dietary Proteins; D003576:Electron Transport Complex IV / Q000378:metabolism; D002149:Energy Intake; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009765:Obesity / Q000503:physiopathology
D004044:Dietary Proteins; D003576:Electron Transport Complex IV