Evaluation of triple drug chemotherapy with or without right nephrectomy in the treatment of bilateral murine Wilms' tumor.
The effect of nephrectomy with or without chemotherapy was evaluated in bilateral implanted Wilms' tumor. There was no significant effect of chemotherapy on survival, primary tumor growth or the incidence of metastases to the lungs demonstrated in this study. Regrowth of tumor at the site of unilateral nephrectomy was prevented by the use of chemotherapy when nephrectomy was performed on day 3. The weight of the left kidney at autopsy of animals treated with nephrectomy only was greater than that of animals who received no treatment following bilateral implantation, suggesting that nephrectomy indirectly may have stimulated tumor growth in the residual kidney. The results suggested that future experimental studies of bilateral Wilms' tumor should include surgery and/or irradiation of the remaining kidney.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D009368:Neoplasm Transplantation; D009392:Nephrectomy; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000628:therapy*
D000970:Antineoplastic Agents; D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin