Experimental ulcerative herpetic keratitis. IV. Preliminary observations on the efficacy of a herpes simplex subunit vaccine.
Systemic vaccination of rabbits with an inactivated type 1 virus subunit vaccine induced humoral and cell-mediated immune responses. Following ocular infection with type 1 herpes virus corneal ulceration and virus excretion were reduced in the vaccinated rabbits.
D000818:Animals; D000917:Antibody Formation; D003229:Conjunctival Diseases / Q000517:prevention & control; D003320:Corneal Ulcer / Q000517:prevention & control; D004306:Dose-Response Relationship, Immunologic; D007111:Immunity, Cellular; D007635:Keratitis, Dendritic / Q000276:immunology / Q000517:prevention & control*; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology*; D014765:Viral Vaccines / Q000627:therapeutic use*
D014765:Viral Vaccines