Fast hardening aminoacid-solution as potential carrier of chemotherapeutic agents in the treatment of chronic osteomyelitis.
Report about an aminoacid, which hardens quickly in liquid environment. It is highly suitable as carrier of chemotherapeutic agents. In-vitro tests show an antibiotic inhibitory activity of different compounds for at least 41 days. According to in-vivo experiments in 17 rats the new substance is replaced in the bone and in soft tissues by fibrous tissue; the antibiotic activity is released slowly. This offers a new carrier which is suitable for occlusion of cavities. The instillation of the new amino-acid (Ethibloc) combined with antibiotics could be a new treatment for chronic osteomyelitis.
D000818:Animals; D002439:Cefotaxime / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D003973:Diatrizoate; D004338:Drug Combinations; D005227:Fatty Acids; D005839:Gentamicins / Q000627:therapeutic use; D010019:Osteomyelitis / Q000188:drug therapy*; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015028:Zein
D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005227:Fatty Acids; D005839:Gentamicins; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D015028:Zein; C020481:alcoholic prolamine solution; D002439:Cefotaxime