Halopemide and benzodiazepine binding sites.
Halopemide inhibits 3H-BZ binding to crude and washed rat forebrain membranes with IC50 values of 16-25 microM. Its putative metabolites are considerably less active. The actions of halopemide are probably not directly related to its ability to interfere with high-affinity 3H-GABA binding sites. However, halopemide may have some unique properties in this regard.
D000818:Animals; D001921:Brain / Q000378:metabolism; D003975:Diazepam / Q000378:metabolism; D004294:Domperidone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005445:Flunitrazepam / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000378:metabolism*; D011963:Receptors, GABA-A
D011955:Receptors, Drug; D011963:Receptors, GABA-A; D004294:Domperidone; D005445:Flunitrazepam; C017357:halopemide; D003975:Diazepam