Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis.
A 9 year old Mexican boy presented with severe hypertension, hypokalaemia and features suggesting acute glomerulonephritis. Nephrosclerosis was present on renal biopsy. Aldosterone levels were unresponsive to variations in dietary salt intake and plasma renin activity was suppressed. Following oral dexamethasone therapy (2 mg/day), plasma aldosterone decreased to undetectable levels, serum potassium normalized and plasma renin activity gradually increased. Dexamethasone also restored the normal responsiveness of the renin-aldosterone system to postural stimuli. The patient exhibited a marked response to a single dose of ACTH with a rise in plasma aldosterone. Long-term blood pressure control and normal potassium levels have been achieved with oral prednisone therapy (5 mg/day) for a period of one year. This case of dexamethasone suppressible hyperaldosteronism (DSH) illustrates that the degree of hypertension in this syndrome may produce severe renal microvascular lesions. DSH should be considered in all children who present with low renin hypertension.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000097:blood; D002648:Child; D003907:Dexamethasone / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000188:drug therapy*; D006973:Hypertension / Q000150:complications; D007668:Kidney / Q000473:pathology*; D008297:Male; D009400:Nephrosclerosis / Q000150:complications*; D012083:Renin / Q000097:blood
D000450:Aldosterone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D012083:Renin