title: The internal organization of the varicella-zoster virus genome.
abstract: DNA was extracted from varicella-zoster (VZ) virions prepared in sucrose gradients. Thirty-eight molecules examined by electron microscopy were found to have a mean length of 46.7 micrometers. Examination of self-annealed VZV DNA molecules revealed that the virus genome was composed of a unique linear large sequence with a mol. wt. of 74.4 X 10(6) to 78.4 X 10(6), and a unique short sequence of mol. wt. approx. 9.8 X 10(6) flanked by inverted repeat sequences of 4.7 X 10(6) mol. wt.
mesh_terms: D001483:Base Sequence; D004279:DNA, Viral; D005814:Genes, Viral; D014645:Herpesvirus 3, Human / Q000235:genetics*; D008854:Microscopy, Electron; D008970:Molecular Weight; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004279:DNA, Viral