Cell-membrane receptors for purines. Review.
Purines are involved in many aspects of cell chemistry - intermediary metabolism, nucleic acid synthesis, and the supply of high-energy phosphates to various active transport systems. In addition, however, there appear to be specific receptor molecules located within the plasma membrane of some cells, which mediate changes of cell function in response to purines present in the extracellular fluid. It is the purpose of this review to summarize the kind of functions subserved by those receptors as well as the basic structural requirements for their activation.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002415:Cats; D002462:Cell Membrane / Q000378:metabolism*; D002468:Cell Physiological Phenomena; D000242:Cyclic AMP / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects; D011687:Purines / Q000494:pharmacology / Q000502:physiology; D011869:Radioligand Assay; D051381:Rats; D011955:Receptors, Drug / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A; D011983:Receptors, Purinergic; D014149:Tranquilizing Agents / Q000494:pharmacology
D007473:Ion Channels; D011687:Purines; D011955:Receptors, Drug; D011963:Receptors, GABA-A; D011983:Receptors, Purinergic; D014149:Tranquilizing Agents; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D000262:Adenylyl Cyclases