title: [Incompatibility of cefotiam dihydrochloride in parenteral preparation by high-performance liquid chromatography].
abstract: Change in external appearance, pH values and residual antimicrobial potency of cefotiam dihydrochloride (CTM) upon combination with infusion solutions and other injections was investigated. The combinations of CTM with bromhexine hydrochloride 2 mg/ml, 2 ml, dipyridamole 5 mg/ml, 2 ml and gabexate mesilate 100 mg/vial respectively were found to be incompatible on account of turbidity produced. As for 34 other combinations, no change in their appearance, pH and potency was observed.
mesh_terms: D001964:Bromhexine; D002439:Cefotaxime / Q000031:analogs & derivatives*; D015310:Cefotiam; D002851:Chromatography, High Pressure Liquid; D004176:Dipyridamole; D004338:Drug Combinations; D004344:Drug Incompatibility; D004347:Drug Interactions; D004355:Drug Stability; D016670:Gabexate; D006146:Guanidines; D006863:Hydrogen-Ion Concentration; D012996:Solutions
chemical_list: D004338:Drug Combinations; D006146:Guanidines; D012996:Solutions; D016670:Gabexate; D004176:Dipyridamole; D015310:Cefotiam; D002439:Cefotaxime; D001964:Bromhexine