[Evidence, in uremic man, of the role of beta 2 adrenergic receptors in the secretion of parathyroid hormone and calcitonin (author's transl)].
In order to determine the effect of beta-blocking agents on secretions of parathyroid hormone and calcitonin, 9 patients with renal failure were given single doses of propranolol (a blocker of the beta 1 and beta 2 receptors) or an equivalent amount of metoprolol (a beta 1 selective agent). Propranolol causes a decrease of plasma parathyroid hormone (p less than 0.02) as well as of calcitonin (p less than 0.05) whereas metoprolol has no effect on the plasma levels of these hormones. These findings suggest that parathyroid tissue and thyroid C cells have receptors that are exclusively of the beta 2 type which are modulating the secretion of parathyroid hormone and calcitonin.
D000328:Adult; D002116:Calcitonin / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D008297:Male; D008790:Metoprolol; D010281:Parathyroid Hormone / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D011433:Propranolol; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D014511:Uremia / Q000503:physiopathology
D010281:Parathyroid Hormone; D010710:Phosphates; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D002116:Calcitonin; D011433:Propranolol; D008790:Metoprolol
Mise en évidence chez l'insuffisant rénal du rôle des récepteurs adrénergiques beta 2 dans la sécretion de l'hormone parathyroïdienne et de la calcitonine.