Effects of intraocular injections of 6-hydroxydopamine on dopamine-dependent cyclic AMP accumulation in intact pieces of carp retina.
Dopamine-stimulated cyclic AMP accumulation was measured in intact pieces of carp retina following intraocular injections of the dopaminergic neurotoxin 6-hydroxydopamine (6-OHDA). This treatment is known to induce a selective destruction of dopaminergic nerve terminals, and in these experiments caused a 94% reduction in retinal dopamine content. However, dopamine-dependent cyclic AMP accumulation was essentially unaltered in retinas exposed to 6-OHDA, indicating that the dopamine receptors linked to adenylate cyclase in the carp retina are located mainly on postsynaptic elements, and not presynaptically on the dopaminergic terminals.
D000818:Animals; D002347:Carps; D000242:Cyclic AMP / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007395:Interneurons / Q000187:drug effects; D016627:Oxidopamine; D012160:Retina / Q000187:drug effects* / Q000378:metabolism
D006892:Hydroxydopamines; D016627:Oxidopamine; D000242:Cyclic AMP; D004298:Dopamine