title: Rat pro-opiomelanocortin contains sulfate.
abstract: Intermediate lobes isolated from rat pituitary glands incorporated [35S]sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis*; D000595:Amino Acid Sequence; D000818:Animals; D066298:In Vitro Techniques; D007700:Kinetics; D007930:Leucine; D010902:Pituitary Gland / Q000378:metabolism*; D010908:Pituitary Hormones, Anterior / Q000096:biosynthesis*; D011333:Pro-Opiomelanocortin; D011498:Protein Precursors / Q000096:biosynthesis*; D011865:Radioisotope Dilution Technique; D051381:Rats; D013462:Sulfur Radioisotopes; D013464:Sulfuric Acids / Q000378:metabolism*; D014316:Tritium
chemical_list: D010908:Pituitary Hormones, Anterior; D011498:Protein Precursors; D013462:Sulfur Radioisotopes; D013464:Sulfuric Acids; D014316:Tritium; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D007930:Leucine