title: Glucagon-induced densensitization: correlation between cyclic AMP levels and contractile force.
abstract: Desensitization of guinea pig left atria to the inotropic effects of glucagon was produced in vitro by treatment of the atria with 10(-6) M glucagon for 2 or 15 min. Desensitization of the contractile response was associated with a loss of the ability of glucagon to elevate cyclic AMP levels. A highly significant correlation was found between the increase in contractile force and the increase in cyclic AMP levels in control and glucagon desensitized left atria.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005934:Glucagon; D000242:Cyclic AMP