title: Renin and aldosterone responses to short-term NaCl or NaHCO3 loading in man.
abstract: We compared the effects of 500 ml of 0.15M NaCl or 750 ml of 0.15M NaHCO2, infusions on PRA and PAC in 16 normal NaCl-restricted men. More positive sodium balance, greater natriuresis, and lower serum chloride, potassium, and hydrogen ion concentrations were observed after NaHCO3 infusion. PRA decreased (13.8 +/- 1.0 ng/ml angiotensin I per hour to 6.6 +/- 0.70) and PAC did not change (98 +/- 15 ng/dl to 86 +/- 15) after NaCl infusion. Conversely, PRA did not change (9.9 +/- 1.6 to 10.1 +/- 1.6) and PAC decreased (85 +/- 9 to 44 +/- 5) after NaHCO3 infusion. Plasma cortisol declined in both groups. These results suggest that in sodium-restricted man chloride is more important than sodium for the suppression of PRA by NaCl loading and that potassium or hydrogen ion is a more sensitive modulator of aldosterone secretion than is renin.
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D001639:Bicarbonates / Q000494:pharmacology*; D002712:Chlorides / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004573:Electrolytes / Q000097:blood / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000494:pharmacology*
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D004573:Electrolytes; D012965:Sodium Chloride; D000450:Aldosterone; D017693:Sodium Bicarbonate; D012083:Renin; D006854:Hydrocortisone