Fecal sterols and bacterial beta-glucuronidase activity: a preliminary metabolic epidemiology study of healthy volunteers from Umea, Sweden, and metropolitan New York.
The dietary pattern, fecal bile acid and neutral sterol concentrations, and the bacterial beta-glucuronidase activity of 2 population groups with a varied risk for colon cancer development (i.e., a high-risk population in the metropolitan New York area and an intermediate-risk population in Umea, Sweden) were investigated. The average daily intake of dietary protein was the same in the 2 groups, but the fat intake was higher in Umea than in New York. The daily total fiber intake was also higher in Umea, as was the daily total stool output. The concentration of fecal secondary bile acids and beta-glucuronidase activity was lower in Umea than in New York, but the total daily excretion of these constituents was the same in both groups. The data suggest that one of the factors contributing to the lower risk of colon cancer in Umea, despite the high dietary fat intake, is the high intake of dietary whole grain and cereal fiber, which leads to an increase in stool bulk, thus diluting and/or binding promoters.
D001419:Bacteria / Q000201:enzymology*; D001647:Bile Acids and Salts / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000209:etiology*; D004032:Diet; D004041:Dietary Fats / Q000009:adverse effects; D004043:Dietary Fiber / Q000494:pharmacology; D005243:Feces / Q000032:analysis* / Q000382:microbiology; D005260:Female; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009519:New York City; D012306:Risk; D013261:Sterols / Q000378:metabolism*; D013548:Sweden
D001647:Bile Acids and Salts; D004041:Dietary Fats; D004043:Dietary Fiber; D013261:Sterols; D005966:Glucuronidase