Determination of left-ventricular volume from first-pass kinetics of labeled red cells.
A mathematical model is presented for the dynamics of a bolus of technetium-99m-labeled red blood cells through the left ventricle. It is used to correct for attenuation the count rate observed over the left ventricle during a conventional gated blood-pool study. The left-ventricular volumes are calculated from the corrected count rates and expressed as a percentage of total blood volume, or in absolute terms if a blood sample is obtained. The procedure is applied to a number of patients with nonvalvular cardiac disease. Cardiac volumes determined by the method are found to correlate well (r = 0.98) with those determined by contrast left ventriculography. The method is simple, requires no special equipment, and can be applied with existing computer software.
D000328:Adult; D000368:Aged; D002302:Cardiac Output; D004912:Erythrocytes; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013318:Stroke Volume; D013667:Technetium
D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m