title: Disopyramide anticholinergic action.
abstract: The effect of disopyramide on cholinergic transmission has been studied using the frog isolated abdominis rectus preparation and the guinea pig isolated vas deferens hypogastric nerve preparation. Disopyramide (2 X 10(-5) mol litre-1) reduced the response of the abdominis rectus to carbachol (1.36 X 10(-6)--4.8 X 10(-5) mol litre-1). Furthermore, disopyramide (1 X 10(-6)--3 X 10(-4) mol litre-1) produced a concentration-dependent reduction in the response to carbachol (5.46 X 10(-6) mol litre-1). The response to potassium chloride (3.34 X 10(-2) mol litre-1) was unaltered by disopyramide (1 X 10(-6)--3 X 10(-4) mol litre-1). Disopyramide produced a dose-related ganglionic blockade at concentrations greater than 2 X 10(-5) mol litre-1. Complete blockade to ganglionic transmission occurred at 3 X 10(-4) mol litre-1 disopyramide.
mesh_terms: D000009:Abdominal Muscles / Q000294:innervation; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D004206:Disopyramide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007001:Hypogastric Plexus / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D011896:Rana temporaria; D011950:Receptors, Cholinergic / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D010276:Parasympatholytics; D011725:Pyridines; D011950:Receptors, Cholinergic; D011189:Potassium Chloride; D002217:Carbachol; D004206:Disopyramide