Disulfiram treatment of three patients with nickel dermatitis.
Diethyldithiocarbamate chelates nickel and accelerates its excretion in the urine. Disulfiram (Antabuse) splits into two molecules of sodium diethyldithiocarbamate after absorption. Oral administration of disulfiram tablets starting with 50 mg a day with a gradual increase in dosage to 100 mg more than than twice a day readily cleared the eczema in three patients with severe and long-standing nickel contact dermatitis.
D000368:Aged; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000209:etiology; D004221:Disulfiram / Q000627:therapeutic use*; D004050:Ditiocarb / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*
D009532:Nickel; D004050:Ditiocarb; D004221:Disulfiram