Cis-diamminedichloroplatinum(II) modified DNA stimulates far greater levels of S1 nuclease sensitive regions than does the modification produced by the trans- isomer.
D000818:Animals; D002417:Cattle; D002945:Cisplatin / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D004720:Endonucleases / Q000378:metabolism*; D007700:Kinetics; D015719:Single-Strand Specific DNA and RNA Endonucleases; D013237:Stereoisomerism; D013379:Substrate Specificity; D013950:Thymus Gland
C034697:transplatin; D004247:DNA; D004720:Endonucleases; D015719:Single-Strand Specific DNA and RNA Endonucleases; D002945:Cisplatin