Effects of chronic histamine and ovalbumin aerosols on pulmonary beta adrenergic receptors in sensitized guinea pigs.
Using (3H) dihydroalprenolol, we demonstrated that the concentration of pulmonary beta adrenergic receptor binding sites was lower in guinea pigs showing a marked bronchoconstrictive response to histamine and in ovalbumin-treated guinea pigs. This result suggests that the changed concentration of the pulmonary beta receptors in an animal model of asthma could be resulted from bronchoconstriction stress.
D000336:Aerosols; D000818:Animals; D001249:Asthma / Q000139:chemically induced; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects*; D008297:Male; D010047:Ovalbumin / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D000336:Aerosols; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D006632:Histamine; D010047:Ovalbumin