A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam.
The benzodiazepine receptor antagonist 3-hydroxymethyl-beta-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-beta-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D005479:Flurazepam / Q000037:antagonists & inhibitors*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011963:Receptors, GABA-A; D012890:Sleep / Q000187:drug effects*; D014851:Wakefulness / Q000187:drug effects
D002243:Carbolines; D007211:Indoles; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; C031516:3-hydroxymethyl-beta-carboline; D005479:Flurazepam