title: Human serum albumin labelled with 99Tcm and 131I for total blood volume determination: A critical and comparative analysis in vivo and in vitro.
abstract: The increased plasma volume or total blood volume determined with radioactive tracers often have no physical or pathologic explanation. The plasma volume and blood dilution were simultaneously measured in 5 patients who had received human serum albumin labelled with 99Tcm or 131I. In each case and for each tracer, a biexponential dilution curve was obtained. The measured plasma volume was consistently higher after 99Tcm-labelled albumin. The results are correlated with the presence of non-protein artifacts arising from the labelling process and proteinaceous compounds arising from denaturation.
mesh_terms: D001811:Blood Volume Determination / Q000379:methods*; D002850:Chromatography, Gel; D005260:Female; D006207:Half-Life; D006349:Heart Valve Diseases / Q000097:blood* / Q000601:surgery; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D008297:Male; D008954:Models, Biological; D011865:Radioisotope Dilution Technique; D011933:Reagent Kits, Diagnostic; D012016:Reference Values; D012709:Serum Albumin / Q000032:analysis; D013667:Technetium
chemical_list: D007457:Iodine Radioisotopes; D011933:Reagent Kits, Diagnostic; D012709:Serum Albumin; D013667:Technetium