Effect of vitamin A palmitate on mutagenesis induced by polycyclic aromatic hydrocarbons in human cells.
The effect of vitamin A palmitate (VAP) on mutagenesis induced by polycyclic aromatic hydrocarbons (PAH) was examined in a human epithelial-like cell line (EUE). Cultures were exposed to benzo[a]pyrene (BP), 3-methylcholanthrene (MCA), 7,12-dimethylbenz[a]anthracene, with or without VAP, and mutation frequencies were determined by selection against diphtheria toxin. A strong inhibition of mutagenesis was observed particularly with MCA and BP. VAP, in the same cell line, reduced 3H-labeled PAH binding to DNA.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000633:toxicity*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes; D004848:Epithelium / Q000187:drug effects; D006801:Humans; D008748:Methylcholanthrene / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D004224:Diterpenes; D009153:Mutagens; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene