Microwave-induced hyperthermia and ionizing radiation. Preliminary clinical results.
The combination of microwave-induced (2450 MHz) hyperthermia and ionizing radiation was used in 7 patients with superficial malignant tumours, which were considered refractory to other therapy. A newly developed heating system was used, allowing for a maintained temperature at the master probe of 42.5 degrees C +/- 0.5 degrees C during 45 min, but temperature measurements at multiple sites showed a marked variation. This preliminary series indicates that the combination of hyperthermia and ionizing radiation may be useful, the response rate (complete or partial) being 8 of 8 evaluable lesions. Even previously heavily irradiated sites responded. Technical improvements are highly needed to allow for controlled heating of any tissue volume.
D000230:Adenocarcinoma / Q000532:radiotherapy; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy; D003201:Computers; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008872:Microwaves / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010307:Parotid Neoplasms / Q000473:pathology / Q000532:radiotherapy; D012509:Sarcoma / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000532:radiotherapy*; D013997:Time Factors