A study of ten red cell enzymatic markers in the Naples' population. Report of a new GPT variant phenotype.
A sample of the population of Naples has been examined for several red cell enzyme markers. About 2,000 newborn have been analyzed for ACP, GLO I, and UMPK; 1,000 of them were also analyzed for PepA and PepB, and 500 for PGM1 and PGM2. In addition about 400 school children have been typed for the PGD and PGP polymorphisms. The observed gene frequencies for the polymorphic systems are: ACPA = 0.293, ACPB = 0.667 and ACPC = 0.040; GLO1 = 0.372; GPT2 = 0.462; UMPK2 = 0.029; PGM21 = 0.279; PGDC = 0.037; PGP1 = 0.953, PGP2 = 0.038 and PGP3 = 0.009. Moreover during the screening of PepA, PepB and GPT markers, some rare alleles have been encountered, one of which, at the GPT locus, has never been reported before. We propose for it the name GPT10.
D000135:Acid Phosphatase / Q000235:genetics; D000410:Alanine Transaminase / Q000235:genetics*; D002648:Child; D004798:Enzymes / Q000235:genetics*; D004912:Erythrocytes / Q000201:enzymology*; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D007231:Infant, Newborn; D007558:Italy; D009703:Nucleoside-Phosphate Kinase / Q000235:genetics; D010447:Peptide Hydrolases / Q000235:genetics; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics; D010734:Phosphogluconate Dehydrogenase / Q000235:genetics; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics; D011110:Polymorphism, Genetic
D004798:Enzymes; D005819:Genetic Markers; D010734:Phosphogluconate Dehydrogenase; D000410:Alanine Transaminase; C023276:uridine monophosphate kinase; D009703:Nucleoside-Phosphate Kinase; C022408:phosphoglycolate phosphatase; D000135:Acid Phosphatase; D010744:Phosphoric Monoester Hydrolases; D010447:Peptide Hydrolases; D010733:Phosphoglucomutase