Membrane-mediated alterations of intracellular Na+ and K+ in lytic-virus-infected and retrovirus-transformed cells.
Infection of chick-embryo fibroblasts and other cells by certain animal viruses results in alterations in the intracellular concentrations of Na+ and K+. Dramatic alterations in monovalent-cation concentrations of lytic-virus-infected cells may favor the synthesis of viral proteins over cellular proteins. More subtle alterations in retrovirus-transformed cells may result in the expression of many morphological and biochemical changes associated with the transformed phenotype.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002642:Chick Embryo; D006224:Cricetinae; D005347:Fibroblasts / Q000502:physiology; D007668:Kidney; D011188:Potassium / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D012190:Retroviridae / Q000235:genetics*; D012845:Sindbis Virus / Q000235:genetics; D012964:Sodium / Q000378:metabolism*; D014721:Vesicular stomatitis Indiana virus / Q000235:genetics
D012333:RNA, Messenger; D012964:Sodium; D011188:Potassium