Dietary fiber and cholesterol and bile acid metabolisms in axenic (germfree) and holoxenic (conventional) rats. II. Effect of pectin.
Axenic and holoxenic rats were fed with a semi-synthetic diet containing 5 p. 100 pectin as the only fiber. Although the microbial flora of the digestive tract converted most of the bile acids in holoxenic rats, it hardly changed the other characteristics of cholesterol and bile acid metabolisms, except intestinal bile salt pools which were much larger in the axenic rats. When the pectin-containing and pectin-free diets were compared, it appeared that the former diet increased cecal weight, especially in axenic rats, but slightly modified cholesterol and bile acid metabolisms. However, the values of some characteristics of those metabolisms varied individually in the holoxenic rat fed with the pectin-containing diet, while they were very homogeneous in the other groups. This heterogeneity might result from pectin-digestive tract microbial flora interactions which would vary among individuals.
D000375:Aging; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism*; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D005856:Germ-Free Life; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010368:Pectins / Q000494:pharmacology*; D051381:Rats
D001647:Bile Acids and Salts; D004043:Dietary Fiber; D010368:Pectins; D002784:Cholesterol