Effect of high concentrations of cAMP on proliferative activity of V79-1A cells.
We studied the mechanisms of the inhibitory effect of high cAMP concentrations on growth of Chinese hamster V79-1A cells. High cAMP concentrations inhibit growth of V79-1A cells in the S phase of the cell cycle. The inhibition is probably due to some effect on the metabolism of DNA precursors. We suggest that this inhibition is not induced by the cyclic nucleotide itself, but by AMP as a degradation product of cAMP.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D000242:Cyclic AMP / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects; D007700:Kinetics; D008168:Lung; D014176:Protein Biosynthesis; D013806:Theophylline / Q000494:pharmacology
D003994:Bucladesine; D013806:Theophylline; D000242:Cyclic AMP