title: Beta adrenergic receptors in pigmented ciliary processes.
abstract: Beta adrenergic receptors from membrane fragments of pigmented sheep eyes were studied and characterised by ligand binding techniques after the removal of melanin. In a representative experiment the beta max (total number of beta receptors) was 394.9 fmol/mg protein. The receptor affinity (Ka) was 440 pM. The potency series of drugs to displace 125I-HYP from the receptors was timolol  = (-) propranolol greater than (+) propranolol greater than salbutamol greater than practolol. beta 1 Receptors were not detected in the ciliary processes. beta 2 Receptors were the prominent adrenergic receptors present. The theory as to how beta blockers work in glaucoma, their site of action, and the potential role of beta 2 blockers for use in intraocular pressure control is discussed.
mesh_terms: D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002924:Ciliary Body / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010858:Pigmentation; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*; D012756:Sheep; D013999:Timolol / Q000494:pharmacology
chemical_list: D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; C011878:iodohydroxybenzylpindolol; D013999:Timolol; D011433:Propranolol; D010869:Pindolol; D000420:Albuterol; D011217:Practolol