title: Carcinogenicity of airborne fine particulate benzo(a)pyrene: an appraisal of the evidence and the need for control.
abstract: Benzo(a)pyrene(BaP) originating from fossil fuel and other organic combustion processes is largely adsorbed on fine particulate and hence is a widespread atmospheric pollutant. Available emissions and air quality data are based on the total weight of particulate matter without reference to size and give little information on trends and concentrations of fine particulate BaP. Greater reliance on coal, synfuels and diesel fuel for energy production and transportation will significantly increase ambient levels of BaP. Because of the particulate size, BaP is substantially deposited in the lower lung and readily eluted into surrounding tissue. After elution in the lung, BaP is metabolically activated to its electrophilic, carcinogenic from by a complex enzyme system whose activity is increased by prior exposure to air pollutants, cigarette smoke and certain drugs. The resultant diol epoxide metabolite has been shown to bind covalently with the DNA of the lung. In experimental animals, BaP is a potent initiating carcinogen whose action is enhanced by sulfur dioxide, promoting agents and carrier fine particles. The effect of small, divided doses of BaP has been shown to be greater than that of a single high dose; no threshold has been established. Epidemiological studies show that mixtures containing BaP (such as urban air, industrial emissions and cigarette smoke) are carcinogenic and may interact synergistically. Occupational studies indicate that the action of BaP-containing mixtures is enhanced in the presence of SO2. However, quantitative risk assessment for BaP is precluded by problems in extrapolating to the general population from small-scale animal studies; uncertainties in findings of epidemiology; and imprecise exposure data. Existing stationary and mobile controls preferentially remove coarse particulate matter and are inefficient collectors of the particulate BaP. In the current absence of health and environmental standards for BaP, there is little incentive to control BaP emissions. BaP meets the criteria for regulation under the Clean Air Act; however, no such BaP standards have yet been proposed.
mesh_terms: D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D000397:Air Pollution / Q000517:prevention & control*; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D002274:Carcinogens, Environmental; D004247:DNA / Q000378:metabolism; D004813:Epidemiology; D006801:Humans; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010316:Particle Size; D014481:United States
chemical_list: D000393:Air Pollutants; D001580:Benzopyrenes; D002274:Carcinogens, Environmental; D001564:Benzo(a)pyrene; D004247:DNA; D006899:Mixed Function Oxygenases