The Eaton-Lambert syndrome.
The Eaton-Lambert syndrome is a non-metastatic manifestation of oat-cell carcinoma of the bronchus, although it has been reported in patients with carcinoma at other sites. The clinical picture is usually one of subacute muscular fatiguability with weakness and wasting affecting the proximal parts of the limbs and trunk, but occasionally the external ocular and bulbar muscles are involved. The weakness is often myasthenic, but it has been observed that muscle power may in fact increase after brief exercise. The pathogenesis, diagnosis, electrophysiological features and some aspects of therapy are reviewed.
D018288:Carcinoma, Small Cell / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D009123:Muscle Hypotonia / Q000150:complications* / Q000175:diagnosis / Q000209:etiology; D009157:Myasthenia Gravis / Q000175:diagnosis; D013577:Syndrome