Field trials of pyrantel pamoate (Combantrin) in Ascaris, hookworm and Trichuris infections.
In a trial involving 185 school children, pyrantel pamoate (Combantrin) at a dose of 20 mg/kg body weight for 1-3 days was found to be very effective against the Ascaris and moderately effective against the hookworm, with mean cure rates ranging from 93.3-96.7% and 53.3-73.3% respectively. No apparent action against the Trichuris was detected, a mean cure rate of between 34.2 and 46.1% being only slightly, but not significantly, better than the 33.8% cure for a placebo-treated control group. Single and multiple doses of the suspension and tablet formulations of the drug were well tolerated. From the series of randomized and controlled trials conducted, we recommend that, in this area, the appropriate dose of the drug to use for treating ascariasis is 10 mg/kg per day for 1 day, and for infections which include hookworm, 20 mg/kg per day for 3 days.
D000293:Adolescent; D001196:Ascariasis / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D006725:Hookworm Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010270:Parasite Egg Count; D011715:Pyrantel / Q000031:analogs & derivatives*; D011716:Pyrantel Pamoate / Q000009:adverse effects / Q000627:therapeutic use*; D014257:Trichuriasis / Q000188:drug therapy*
D011715:Pyrantel; D011716:Pyrantel Pamoate