Ethyl beta-carboline-3-carboxylate reverses the diazepam effect on cerebellar cyclic GMP.
The administration of ethyl beta-carboline-3-carboxylate (beta-CCE), a ligand for benzodiazepine receptors, did not affect the cerebellar cyclic GMP level in mice, but giving beta-CCE together with diazepam significantly inhibited the diazepam-induced decrease in cyclic GMP. The fact that no antagonism was observed when beta-CCE was given 15 min before the diazepam treatment indicates that beta-CCE is short-acting. These biochemical observations support the conclusions from behavioral and electrophysiological studies which indicated that beta-CCE is a short-acting antagonist of benzodiazepines.
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D002531:Cerebellum / Q000032:analysis* / Q000187:drug effects; D006152:Cyclic GMP / Q000032:analysis*; D003975:Diazepam / Q000037:antagonists & inhibitors*; D007211:Indoles / Q000494:pharmacology*; D008024:Ligands; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D002243:Carbolines; D007211:Indoles; D008024:Ligands; C024915:beta-carboline-3-carboxylic acid ethyl ester; D006152:Cyclic GMP; D003975:Diazepam