Effects of chronic morphine administration on catecholamines and beta-adrenergic receptors of the superior cervical ganglion and iris of the rat.
The action of chronic morphine administration on catecholamine levels in the cervical (SCG) and iris of the rat pup was studied by radioenzymatic assay. Catecholamine levels in the SCG and iris were unaltered after chronic morphine administration and withdrawal. Norepinephrine (NE) uptake was unchanged throughout drug treatment. beta-adrenergic receptors were increased 30.8% in the iris of morphine-dependent animals. This increase in beta receptors closely parallels the increase in beta receptors found in the brainstem of adult morphine-dependent animals.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004082:Dihydroalprenolol / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism*; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000378:metabolism*; D007498:Iris / Q000187:drug effects / Q000378:metabolism*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D009270:Naloxone; D004082:Dihydroalprenolol; D009020:Morphine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine