title: Characteristics of apparent derivatives of the 2512 strain of infectious bursal disease virus when used as vaccines.
abstract: The 2512 infectious bursal disease virus (IBDV) strain maintained in the authors' laboratory was compared with apparent 2512 IBDV isolates designated I-2512, P-2512, and H-2512. The latter three viruses were obtained from different sources and, ostensibly, had their origin in the Purdue laboratory. Their effects on immunogenicity, transmissibility, pathogenicity, and cell cultures varied. One of these isolates was said to be only 2 embryo passages higher than the original seed virus in our laboratory. Included in the study, also for comparison, was a cell-cultured-adapted 2512-cloned attenuated virus. The findings emphasize changes that may occur in the identity of a virus from manipulation, mutation, storage, errors in labeling, or other factors. These characteristics should be identified if the virus is to be used as a vaccine, in research, or for other purposes. The need for well-characterized reference strains in repositories is discussed relative to their importance in potential vaccine research and development.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D002642:Chick Embryo; D002645:Chickens / Q000276:immunology; D007243:Infectious bursal disease virus / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D011234:Precipitins / Q000032:analysis*; D012087:Reoviridae / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014776:Virus Cultivation
chemical_list: D000914:Antibodies, Viral; D011234:Precipitins; D014765:Viral Vaccines