Partial myeloperoxidase deficiency.
Neutrophil myeloperoxidase (MPO) activity was analyzed by a semi-quantitative cytochemical method in 268 subjects divided into several groups. 17 subjects with significantly reduced MPO activity were found: 11 of 23 in the preleukemia group, 2/14 AMLs, 1/20 myeloproliferative syndrome, 1/7 carcinoma with bone marrow metastases, 1/33 diabetes mellitus and 1/50 normals. Only in the preleukemia group, was MPO significantly reduced in comparison to the normal group (p less than 0.005). The high frequency of acquired MPO deficiency in preleukemia represents a useful criterium for this diagnosis. Furthermore, in these patients, as well as in the other subjects studied, no apparent correlation between MPO level and infection could be demonstrated.
D002178:Candidiasis, Chronic Mucocutaneous / Q000201:enzymology; D004796:Clinical Enzyme Tests; D003920:Diabetes Mellitus / Q000201:enzymology; D003937:Diagnosis, Differential; D006801:Humans; D007239:Infections / Q000201:enzymology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology; D008232:Lymphoproliferative Disorders / Q000201:enzymology; D009196:Myeloproliferative Disorders / Q000175:diagnosis* / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology; D009195:Peroxidase / Q000097:blood / Q000172:deficiency*; D010544:Peroxidases / Q000172:deficiency*; D011289:Preleukemia / Q000175:diagnosis* / Q000201:enzymology
D010544:Peroxidases; D009195:Peroxidase