Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene.
Nonrandom chromosome rearrangements of chromosome 22 have been identified in different human malignancies. As a result of Southern blot hybridization of a c-sis probe to DNA's from mouse-human somatic cell hybrids, the human homolog (c-sis) of the transforming gene of simian sarcoma virus was assigned to chromosome 22. Hybrids between thymidine kinase-deficient mouse cells and human fibroblasts carrying a translocation of the region q11-qter of chromosome 22 to chromosome 17 were also analyzed. These studies demonstrate that the human c-sis gene is on region 22q11 greater than qter.
D002472:Cell Transformation, Viral; D002874:Chromosome Mapping; D002904:Chromosomes, Human, 21-22 and Y; D005796:Genes; D006801:Humans; D009857:Oncogenes; D012190:Retroviridae / Q000235:genetics*; D012842:Sarcoma Virus, Woolly Monkey / Q000235:genetics*