Influence of pH on ketoconazole activity against Candida parapsilosis and Candida albicans.
Experiments involving viable count determinations during incubation of yeasts in a synthetic liquid medium showed that ketoconazole was significantly more active at pH 7.0 than it was at pH 5.5 against strains of Candida parapsilosis and Candida albicans.
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology*; D007654:Ketoconazole; D010879:Piperazines / Q000494:pharmacology*
D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D007654:Ketoconazole