title: Studies on viral respiratory disease in laboratory cats. I. Isolation of feline herpesvirus and choice of proper disinfectant.
abstract: In the laboratory cat colony consisted of 14 Korats and 8 Japanese native cats, the disease characterized by upper respiratory signs occurred. Seven cytopathogenic agents were isolated from the oropharyngeal swabs and necropsy materials of affected cats by means of inoculation to primary feline kidney cell cultures. One of the isolates (KS-1 strain) was identical with feline herpesvirus (FHV), and appeared to be a causal agent of the trouble. Properties of the KS-1 strain were in general agreement with the known strains of FHV. Serologic examination and clinical analysis suggested that Japanese native cats became carriers, re-excreted the virus and spread it to susceptible cats. Virucidal activities of several disinfectants against FHV, comparing with a feline calicivirus (FCV), were studied and the following conclusions reached: 1) Sodium hypochlorite, iodine complex, benzethonium chloride and chlorhexidine were effective against FHV at commonly used concentrations. 2) Among chemicals tested sodium hypochlorite was most effective against FCV and followed by iodine complex. 3) Benzethonium chloride and chlorhexidine had little efficacy against FCV at commonly used doses.
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D002371:Cat Diseases / Q000382:microbiology*; D002415:Cats; D004202:Disinfectants / Q000494:pharmacology*; D005260:Female; D006564:Herpesviridae / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000382:microbiology / Q000662:veterinary*; D008297:Male; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000662:veterinary*; D012973:Sodium Hypochlorite / Q000494:pharmacology
chemical_list: D004202:Disinfectants; D012973:Sodium Hypochlorite