title: An outbreak of hand, foot, and mouth disease in Singapore.
abstract: Epidemiological studies were carried out during an extensive outbreak of hand, foot and mouth disease caused by coxsackievirus A 16 in Singapore in 1981. Most of the cases were concentrated in densely populated public housing estates, and the morbidity rate was highest in children under 5 years of age. The mean secondary attack rate for children under 12 years of age was 76.7% compared with an overall rate of 31.3%. The incubation period ranged from 1 to 7 days. Factors favouring the transmission of infection within a household included sharing of household and personal articles with the index case. The disease was mild and self-limiting.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000453:epidemiology*; D004196:Disease Outbreaks; D004770:Enterovirus / Q000302:isolation & purification*; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D012846:Singapore