Glucagon-induced densensitization: correlation between cyclic AMP levels and contractile force.
Desensitization of guinea pig left atria to the inotropic effects of glucagon was produced in vitro by treatment of the atria with 10(-6) M glucagon for 2 or 15 min. Desensitization of the contractile response was associated with a loss of the ability of glucagon to elevate cyclic AMP levels. A highly significant correlation was found between the increase in contractile force and the increase in cyclic AMP levels in control and glucagon desensitized left atria.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D013997:Time Factors
D005934:Glucagon; D000242:Cyclic AMP