Effect of phenolic compounds on in vivo activity of glucose-6-phosphatase in certain tissues of Notopterus notopterus.
The effects of phenol (P), dinitrophenol (DNP), pentachlorophenol (PCP), and their three combinations--(PCP + DNP)/P (highly antagonistic), (DNP + P)/PCP (additive) and (P + DNP)/PCP (highly synergistic)-- on glucose-6-phosphatase activity in liver, brain, kidney and gills of Notopterus notopterus were studied at three sub-acute concentrations (1/10, 1/15 and 1/20 the fraction of the 96-h LC50) after 15 and 30 days of exposure. When these chemicals were used separately, PCP exerted more effect than DNP and P. Maximum (71.56%) and highly significant (P less than 0.001) inhibition was observed in liver at the highest concentration of (P + DNP)/PCP combination after 30 days exposure, and lowest (3.64%) and insignificant inhibition in kidney at 1/20 of the (PCP + DNP)/P combination after 15 days exposure. Significant (P less than 0.05, P less than 0.01) stimulation in kidney or no effect in other tissues was observed in lower concentrations of P, DNP and (PCP + DNP)/P.
D019297:2,4-Dinitrophenol; D000818:Animals; D001921:Brain / Q000201:enzymology; D004140:Dinitrophenols / Q000633:toxicity; D004347:Drug Interactions; D005399:Fishes / Q000378:metabolism*; D005880:Gills / Q000201:enzymology; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D010416:Pentachlorophenol / Q000633:toxicity; D019800:Phenol; D010636:Phenols / Q000633:toxicity*
D004140:Dinitrophenols; D010636:Phenols; D019800:Phenol; D010416:Pentachlorophenol; D005952:Glucose-6-Phosphatase; D019297:2,4-Dinitrophenol