Glucocorticoids and aspirin inhibit and cyproterone acetate enhances the androgenic response in mouse kidney.
Glucocorticoids and aspirin antagonize the androgenic response in mouse kidney, but not in ventral prostate or seminal vesicles. These agents impeded the testosterone-mediated increase in kidney weight, cytochrome c oxidase, and lysosomal hydrolases and urinary excretion of lysosomal hydrolases and proteins. They also attenuated the testosterone-induced decrease in enzyme latency and membrane stability of kidney lysosomes. In contrast, the antiandrogen cyproterone acetate is weakly androgenic in kidney and potentiates testosterone-induced lysosomal enzymuria and proteinuria (synandrogenic effect).
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D003907:Dexamethasone / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D006596:Hexosaminidases / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008247:Lysosomes / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D017373:Cyproterone Acetate; D003907:Dexamethasone; D003534:Cyproterone; D003576:Electron Transport Complex IV; D006596:Hexosaminidases; D005966:Glucuronidase; D001241:Aspirin