[Clinical evaluation of tissue concentrations of cefotiam applied in the field of thoracic surgery].
Seven patients who were performed thoracotomy for the disease of the chest, were administered cefotiam dihydrochloride 2.0 g for about an hour by intravenous drip infusion during their operation. Antibiotic levels of serum and intrathoracic tissues (a piece of lung parenchyma, parietal pleura, pulmonary hilar lymph node, chest wall muscle, pulmonary cyst and nerve) were determined, and an evaluation of bactericidal effect was discussed. In this study, we found that antibiotic level of poor blood supplied lung, so called the destroyed lung was remarkably high. This means that a high concentration of cefotiam dihydrochloride to intrathoracic tissue is effective against postoperative infection.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D015310:Cefotiam; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control; D014397:Tuberculosis, Pulmonary / Q000601:surgery
D015310:Cefotiam; D002439:Cefotaxime