Drug-induced lipid peroxidation in mice--II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione.
If injected intravenously 2 hr before the drug, a dose of more than 175 mg/kg body weight glutathione (0.57 mmol/kg) protected male mice from acute liver necrosis induced by intraperitoneal administration of 400 mg/kg (2.65 mmol/kg) paracetamol. Soluble glutathione yielded a limited, and liposomally entrapped glutathione an optimal dose-dependent protective effect against drug-induced lipid peroxidation (as measured by in vivo ethane exhalation) liver necrosis (assessed by serum transaminases) and hepatic glutathione depletion (determined post mortem). N-Acetylcysteine solution had no effect in this model.
D000082:Acetaminophen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000517:prevention & control*; D005978:Glutathione / Q000008:administration & dosage* / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism*; D008081:Liposomes; D008297:Male; D051379:Mice; D009336:Necrosis / Q000139:chemically induced / Q000517:prevention & control
D001580:Benzopyrenes; D008054:Lipid Peroxides; D008081:Liposomes; D001564:Benzo(a)pyrene; D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D005978:Glutathione