C-terminal octapeptide of cholecystokinin decreases food intake in obese men.
Six of eight obese men ate significantly less food during an intravenous infusion of the C-terminal octapeptide of cholecystokinin (CCK-8, 4 ng . kg-1 . min-1) than during a saline infusion in a double blind experimental paradigm. Subjects stopped eating sooner during CCK-8. CCK-8 did not change the rate of eating. No overt side effects were reported or observed. This is the first report of the satiety effect of CCK-8 in obese humans and it suggests that the therapeutic potential of CCK-8 for the treatment of obesity deserves investigation.
D001835:Body Weight / Q000187:drug effects*; D002766:Cholecystokinin / Q000627:therapeutic use*; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D006801:Humans; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D010446:Peptide Fragments / Q000627:therapeutic use*; D012844:Sincalide
D010446:Peptide Fragments; D002766:Cholecystokinin; D012844:Sincalide