Organophosphate poisoning: modifications in acid base equilibrium and use of sodium bicarbonate as an aid in the treatment of toxicity in dogs.
We injected technical quality DDVP ip into 13 dogs at a dose of 30 mg/kg, a dose 100% lethal in 27 minutes. We monitored blood pH, arterial gases, and cholinesterase activity before and during the intoxication and found acidosis. We used iv sodium bicarbonate and achieved recovery of acid-base balance, improvement in the poisoned state, and survival of 84.6% of the patients.
D000137:Acid-Base Imbalance / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000378:metabolism; D002802:Cholinesterases / Q000097:blood; D004006:Dichlorvos / Q000506:poisoning; D004283:Dog Diseases / Q000139:chemically induced* / Q000378:metabolism; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D062025:Organophosphate Poisoning; D017693:Sodium Bicarbonate; D013997:Time Factors
D001639:Bicarbonates; D002245:Carbon Dioxide; D004006:Dichlorvos; D017693:Sodium Bicarbonate; D002802:Cholinesterases