Comparison of the inhibitory action of delta-9-tetrahydrocannabinol and petroleum spirit extract of herbal cannabis on human sperm motility.
1 Using the trans-membrane migration method to measure drug effects on human sperm motility, it is found that delta-9-tetrahydrocannabinol is the major constituent of cannabis which inhibits sperm motility and unlike the cataleptic effect, other constituents in the petroleum spirit extract do not potentiate this effect significantly. 2 It is suggested that the mechanisms for sperm immobilization and cataleptic effects are different.
D002188:Cannabis; D013759:Dronabinol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*
D010936:Plant Extracts; D013759:Dronabinol