[Hormonal dependence of the initial stages of heparin clearance during immobilization stress in the rat].
The 30-min immobilization stress reduces intensity of initial stages of heparin clearance in rats due to increased secretion of ACTH: in blockade of ACTH release the intensity of heparin clearance is not reduced whereas in intensifying the immobilization stress with ACTH administration it is reduced more than in immobilization alone. The stress does not accelerate heparin clearance in adrenalectomized animals. Substitutional administration of hydrocortisone normalizes the clearance in these animals. This suggests a permissive role of glycocorticoids in regulation of heparin clearance intensity. Detainment of heparin in the blood stream in stress is causally related to activation of anticoagulating system and to increased non-enzymatic fibrinolytie activity of the blood due to intensified formation of complex heparin compounds.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D005342:Fibrinolysis; D006493:Heparin / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000502:physiology*; D007103:Immobilization; D008297:Male; D051381:Rats; D013315:Stress, Psychological / Q000097:blood*
D003900:Desoxycorticosterone; D000324:Adrenocorticotropic Hormone; D006493:Heparin; D006854:Hydrocortisone
Gormonal'naia obuslovlennost' nachal'nykh étapov klirensa geparina pri immobilizatsionnom stresse u krys.