title: Adjuvant radiation therapy compared with cyclic chemotherapy in patients with mammary carcinoma. I. Changes of blood lymphocyte subpopulations.
abstract: Peripheral lymphocyte subpopulations were examined in 37 women with breast carcinoma who were postoperatively randomized to adjuvant local radiation therapy or cyclic treatment with 5-Fluorouracil, Methotrexate and Chlorambucil. Both T and non-T lymphocyte counts were reduced but the latter subpopulation was reduced to the highest relative extent in both groups of patients. Following radiation therapy the non-T cells repopulated more rapidly than the T cells, whereas the repopulation seemed to be the reverse in patients treated with chemotherapy.
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy; D002699:Chlorambucil / Q000627:therapeutic use; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000502:physiology*; D008408:Mastectomy; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011182:Postoperative Care; D011882:Radiotherapy, High-Energy; D012397:Rosette Formation
chemical_list: D003037:Cobalt Radioisotopes; D002699:Chlorambucil; D005472:Fluorouracil; D008727:Methotrexate