[Low molecular channel-former protein from the mitochondrial membrane].
Individual low molecular weight protein component was isolated by gel-filtration method from the inner mitochondrial membrane. This membrane component increases the conductivity of bilayer lipid membranes (BLM) in the presence of K+ and Ca2+-ions. This phenomenon may be explained by the formation of single conductivity channels. The voltage - current characteristics of this channel is nonlinear, which may be the result of asymmetrical operation of the channel - former in the polarized membrane, in spite of equal concentration of protein on both sides of the membrane.
D000818:Animals; D002118:Calcium; D004553:Electric Conductivity; D007425:Intracellular Membranes / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism*; D008051:Lipid Bilayers; D008565:Membrane Proteins / Q000302:isolation & purification / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D008970:Molecular Weight; D011188:Potassium
D007473:Ion Channels; D008051:Lipid Bilayers; D008565:Membrane Proteins; D011188:Potassium; D002118:Calcium
Nizkomolekuliarnyĭ belok-kanaloformer membrany mitokhondriĭ.