title: Effects of chronic histamine and ovalbumin aerosols on pulmonary beta adrenergic receptors in sensitized guinea pigs.
abstract: Using (3H) dihydroalprenolol, we demonstrated that the concentration of pulmonary beta adrenergic receptor binding sites was lower in guinea pigs showing a marked bronchoconstrictive response to histamine and in ovalbumin-treated guinea pigs. This result suggests that the changed concentration of the pulmonary beta receptors in an animal model of asthma could be resulted from bronchoconstriction stress.
mesh_terms: D000336:Aerosols; D000818:Animals; D001249:Asthma / Q000139:chemically induced; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects*; D008297:Male; D010047:Ovalbumin / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
chemical_list: D000336:Aerosols; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D006632:Histamine; D010047:Ovalbumin