Defective parvoviruses acquired via the transplacental route protect mice against lethal adenovirus infection.
Adeno-associated virus type 1 (AAV-1) interfered with the replication of its murine adenovirus (MAV) helper in primary mouse kidney cells and in 1-day-old ICR mice. Mice carrying AAV-1 acquired via the transplacental route were protected against lethal infection with MAV. The replication of AAV-1 in these mice could be triggered by multiple challenges with MAV, and antibodies to AAV-1 were subsequently detected.
D000256:Adenoviridae / Q000502:physiology*; D000257:Adenoviridae Infections / Q000382:microbiology*; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D002478:Cells, Cultured; D000229:Dependovirus / Q000276:immunology / Q000502:physiology*; D005260:Female; D000882:Haplorhini; D008431:Maternal-Fetal Exchange; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D014762:Viral Interference
D000914:Antibodies, Viral