title: Fast hardening aminoacid-solution as potential carrier of chemotherapeutic agents in the treatment of chronic osteomyelitis.
abstract: Report about an aminoacid, which hardens quickly in liquid environment. It is highly suitable as carrier of chemotherapeutic agents. In-vitro tests show an antibiotic inhibitory activity of different compounds for at least 41 days. According to in-vivo experiments in 17 rats the new substance is replaced in the bone and in soft tissues by fibrous tissue; the antibiotic activity is released slowly. This offers a new carrier which is suitable for occlusion of cavities. The instillation of the new amino-acid (Ethibloc) combined with antibiotics could be a new treatment for chronic osteomyelitis.
mesh_terms: D000818:Animals; D002439:Cefotaxime / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D003973:Diatrizoate; D004338:Drug Combinations; D005227:Fatty Acids; D005839:Gentamicins / Q000627:therapeutic use; D010019:Osteomyelitis / Q000188:drug therapy*; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D015028:Zein
chemical_list: D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005227:Fatty Acids; D005839:Gentamicins; D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D015028:Zein; C020481:alcoholic prolamine solution; D002439:Cefotaxime