[Study of the minimum inhibiting concentration of a new cephalosporin (HR 756): comparative data with other beta-lactamic antibiotics].
HR 756 is a new beta-lactamase resistant cephalosporin. The activity of HR 756 was compared in vitro to that of cefamandole, cefoxitine, cefuroxime and cephalothin. A concentration of 1 microgram/ml inhibited practically all isolates of E. coli, Salmonella, Shigella, Proteus indole + and indole --, Klebsiella, etc. A lower activity in vitro has been found regarding to Enterobacter, Serratia, Citrobacter and Pasteurella. The cefotaxime has some anti-Pseudomonas activity at concentrations of 7.5-15 micrograms/ml. For most Gram-negative organisms, HR 756 was most active. The cephalothin and the cefoxitine have resulted more active regard to Staph. aureus and Bacteroides fragilis, respectively.
D001419:Bacteria / Q000187:drug effects*; D002435:Cefamandole / Q000494:pharmacology; D002439:Cefotaxime / Q000008:administration & dosage / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002512:Cephalothin / Q000494:pharmacology
D002435:Cefamandole; D002440:Cefoxitin; D002439:Cefotaxime; D002444:Cefuroxime; D002512:Cephalothin
Studio sulla minima concentrazione inibente di una nuova cefalosporina (HR 756): dati comparativi con altri antibiotici beta-lattamici.