Neutral glycolipids and gangliosides of concanavalin A-selected SV3T3 revertant cells and of normal and SV40-transformed Balb/c 3T3 cells.
The structural analysis of neutral glycolipids and gangliosides of the SV40 transformed Balb/c3T3 cells (SV3T3 cells) and concanavalin A-selected SV3T3 revertant cells, both compared with untransformed Balb/c3T3 cells, has shown: (i) a content of neutral glycolipids in revertant cells near to that found in the untransformed parental cells; (ii) a similar decrease of the higher gangliosides in transformed and revertant cells; (iii) a content of ganglioside GM3 in revertant cells much higher than that found in both SV3T3 and untransformed Balb/3T3 cells. The possible role of ganglioside GM3 in growth control is discussed.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D003208:Concanavalin A; D005347:Fibroblasts; D005732:Gangliosides; D006017:Glycolipids; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D013539:Simian virus 40
D005732:Gangliosides; D006017:Glycolipids; D003208:Concanavalin A