Generation of cross-reactive cytotoxic T lymphocytes following immunization of mice with various bluetongue virus types.
Mice immunized with a single bluetongue (BT) virus type were shown to produce cytotoxic T lymphocytes (CTL's) which cross-reactive with a number of BT virus types. These cross-reactive CTL's could be induced by both primary in vivo and secondary in vitro stimulation. A varying degree of cross-reactivity occurred with the six BT types examined. Aspects of the character of this cross-reactivity were examined and its role in protection from disease and vaccination strategy is discussed.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001667:Binding, Competitive; D001819:Bluetongue / Q000276:immunology*; D001820:Bluetongue virus / Q000145:classification / Q000276:immunology; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D007114:Immunization; D007117:Immunization, Secondary; D007156:Immunologic Memory; D051379:Mice; D008809:Mice, Inbred C3H; D009500:Neutralization Tests; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology*
D000914:Antibodies, Viral