Combination effect of ceftriaxone with four aminoglycosides on nonfermenting gram-negative bacteria.
The in vitro efficacy of ceftriaxone in combination with gentamicin, tobramycin, amikacin and netilmicin against 50 nonfermenting gram-negative bacterial strains was compared by use of the checkerboard agar dilution technique. On average 42.5% of all nonfermenting strains were inhibited by additive, 22.5% by synergistic ceftriaxone-aminoglycoside combinations. Great variations occurred between the different bacterial species. Ceftriaxone-tobramycin interactions were superior to combinations with other aminoglycosides. Ceftriaxone-aminoglycoside combinations were most active on Pseudomonas aeruginosa and least potent on Pseudomonas cepacia.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D002443:Ceftriaxone; D004357:Drug Synergism; D005285:Fermentation
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D002439:Cefotaxime