Ion transport and adrenergic function in major affective disorder.
Altered functional levels of norepinephrine (NE) have been implicated in the etiology of affective disorders. Abnormalities of membrane ion transport have been postulated to underlie such neurotransmitter imbalances. To evaluate the role of these systems in the pathophysiology of specific affective syndromes, we have examined the NE metabolite MHPG and ion transport function in a cross-section of affective patients in different mood states. Analysis of those data reveals that plasma MHPG levels are dependent on mood state, with bipolar patients in the manic phase having significant elevations of this metabolite. In contrast, the red cell: plasma lithium ratio (LR) was independent of mood state and significantly elevated in a group of bipolar patients.
D000341:Affective Disorders, Psychotic / Q000097:blood*; D001714:Bipolar Disorder / Q000097:blood; D003866:Depressive Disorder / Q000097:blood; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008094:Lithium / Q000097:blood; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D009638:Norepinephrine / Q000502:physiology*; D011618:Psychotic Disorders / Q000097:blood; D012559:Schizophrenia / Q000097:blood; D012964:Sodium / Q000097:blood
D007473:Ion Channels; D008734:Methoxyhydroxyphenylglycol; D008094:Lithium; D012964:Sodium; D009638:Norepinephrine