[Electron microscopic findings in the livers of long-term survivors among child tumor patients after polychemotherapy].
In 14 children which were treated by combined antineoplastic chemotherapy a postexamination was performed after a mean survival time of 5 years and a post-treatment-interval of two and a half years. In this study also liver biopsies were examined by electron microscopy. Ultrastructural changes of the hepatocytes must be explained as a progressive metabolic efficiency of these cells. There was no direction for a chronic damage of the liver parenchyma induced by the therapy.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009369:Neoplasms / Q000188:drug therapy*; D009396:Wilms Tumor / Q000188:drug therapy
D000970:Antineoplastic Agents
Elektronenmikroskopische Leberbefunde bei langzeitüberlebenden Tumorpatienten im Kindesalter nach Polychemotherapie.