title: Cytogenetic effect of two strains of Junin virus in the guinea pig.
abstract: The cytogenetic effect of two strains of Junin virus on bone marrow chromosomes of the guinea pig was studied. Animals infected with the attenuated strain XJ-Cl3 showed no differences from control animals. Guinea pigs inoculated with the pathogenic strain XJ exhibited a significant increase of abnormal cells, chromatid breaks, and chromosome fragments. The clastogenic ability of the XJ strain is similar to the reported effect of other viruses, while the XJ-Cl3 strain does not appear to be clastogenic.
mesh_terms: D000818:Animals; D006477:Arenaviruses, New World / Q000472:pathogenicity / Q000502:physiology; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D006168:Guinea Pigs; D006478:Hemorrhagic Fever, American / Q000235:genetics* / Q000382:microbiology; D008297:Male