The binding of platinum complexes to tuna cytochrome c.
The binding of [PtCl4]2- and cis-[PtCl2(NH3)2] to methionine-65 of tuna cytochrome c was investigated by 1H n.m.r. The modification at methionine-65 is shown to cause an extremely small structural perturbation to the protein at the site of modification.
D000818:Animals; D002945:Cisplatin / Q000378:metabolism*; D003574:Cytochrome c Group / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008715:Methionine / Q000031:analogs & derivatives / Q000378:metabolism; D010984:Platinum / Q000378:metabolism*; D017671:Platinum Compounds; D011485:Protein Binding; D011487:Protein Conformation; D014413:Tuna
D003574:Cytochrome c Group; D017671:Platinum Compounds; D010984:Platinum; C006379:N-acetylmethionine; D008715:Methionine; D002945:Cisplatin; C032741:platinum tetrachloride