Clonal analysis of the BALB/c T cell proliferative response to apo beef cytochrome c.
Murine T cell clones that proliferated specifically in response to the protein antigen apo cytochrome c were derived and maintained in continuous culture. Two distinct clonotypes were observed with respect to the proliferative responses observed when a variety of peptides prepared from several species of cytochrome c were tested. These 2 clonotypes appeared to recognize 2 different regions in the cytochrome c molecule. Only 1 of the 2 clonotypes tested demonstrated helper cell activity for antibody formation in vitro.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D001059:Apoproteins / Q000276:immunology; D002417:Cattle; D002999:Clone Cells / Q000276:immunology; D003574:Cytochrome c Group / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D006736:Horses; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology
D001059:Apoproteins; D003574:Cytochrome c Group; D014301:Trinitrobenzenes