Various phenotypes of diabetes mellitus at ultimate outcome of acutely developed diabetic state induced by viral infection.
For 4 to 8 years we followed up 3 diabetic patients in whom the onset of diabetes seemed to be closely related to the well-documented Epstein-Barr virus infection (Case 1) or Coxsackie B4 virus infection (Case 2, 3). Although all developed acute ketosis-prone diabetes in the convalescent stage of the viral infections, the subsequent clinical courses were quite different from each other. Case 1 has remained consistently insulin-dependent and associated with positive islet cell antibody, gastric parietal cell antibody, thyroglobulin hemoagglutinating antibody and thyroidal microsomal hemoagglutinating antibody. Case 2 restored normal glucose tolerance. Case 3 has become noninsulin-dependent diabetes mellitus after a 6 year interval. Thus, it is reasonably presumed that virus could be responsible for the occurrence of different phenotypes of diabetes.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis; D001323:Autoantibodies; D002648:Child; D003384:Coxsackievirus Infections / Q000150:complications*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D029822:Enterovirus B, Human; D004854:Herpesvirus 4, Human; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D007515:Islets of Langerhans / Q000032:analysis / Q000276:immunology; D008297:Male; D010641:Phenotype; D013972:Thyrotropin / Q000276:immunology
D000906:Antibodies; D001323:Autoantibodies; C024211:islet cell antibody; D013972:Thyrotropin