[Varicella-zoster-immunoglobulin as a safe prophylaxis of varicella (author's transl)].
The occurrence of varicella in the course of immunosuppressive therapy is always a hazard to life. Up till now, passive immunization is the only method which provides reliable protection. We have had an immunoglobulin compound at our disposal during the last 5 years. This compound was obtained by screening a plasmapool for high-titre varicella antibodies, which were then fractionated. Varicella immunoglobulin was injected on 298 occasions to children incubated with varicella. There were no serious side effects after i.v. administration. These children were on polychemotherapy because of malignant diseases. Only 4 children developed varicella, 3 of them very mildly and none of them was later disabled due to varicella in any form. The protective value of this varicella-immunoglobulin compound is much greater than any other known so far [16].
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002644:Chickenpox / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000009:adverse effects / Q000627:therapeutic use*; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007223:Infant; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D007136:Immunoglobulins
Zur Sicherheit der Varizellenprophylaxe mit Varizellen-Zoster-Immunglobulin.