title: [Mechanism of activation of Na,K-ATPase in nerve fibers during rhythmic excitation].
abstract: The activation mechanism of Na,K-ATPase in nerve fibres after rhythmic excitation was studied. 3H-ouabain binding to a nerve was found to depend on the frequency of rhythmic excitation. The maximum of 3H-ouabain binding to a nerve crab was at 10 imp/sec. Rhythmic excitation was found not to change Na,K-ATPase affinity to ouabain, but appeared to increase the concentration of ouabain-sensitive sites in the nerve membrane. Transformation of inactive forms of the enzyme into active ones was supposed to be a possible cause of greater 3H-ouabain binding to the nerve during rhythmic exitation.
mesh_terms: D000818:Animals; D003386:Brachyura; D004558:Electric Stimulation; D007700:Kinetics; D009474:Neurons / Q000201:enzymology*; D010042:Ouabain / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: O mekhanizme aktivatsii Na,K-ATFazy v nervnykh voloknakh pri provedenii ritmicheskogo vozbuzhdeniia.