title: Genetic instability in Drosophila melanogaster: deletion induction by insertion sequences.
abstract: Females of Drosophila melanogaster heteroallelic or homoallelic for X chromosome giant (gt) mutants generate deletions involving the wild-type alleles at two X chromosome gene loci: yellow body color (y) and white eye color (w). The deletions, bidirectional in the case of y and with fixed endpoint in the case of w, are associated with particular X chromosomes. Distinctive insertion sequences, located proximal to the target loci, are presumed to generate the deletions.
mesh_terms: D000818:Animals; D002872:Chromosome Deletion; D003433:Crosses, Genetic; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D005838:Genotype; D006720:Homozygote; D008297:Male; D009154:Mutation; D014960:X Chromosome
chemical_list: D004251:DNA Transposable Elements