[Structure of the tricyclic triaminotricarboxylic acid (Y) from the antibiotic actinoidin].
The products of triaminotricarboxylic acid (Y) transformation in alkaline and reduction (HI/P) hydrolysis and the PMR spectra of the Y-Phe dipeptide were studied and the nature of the 3 amino acid substitutes and their position in the aromatic nuclei were determined. With regard to the data on the structure of the aromatic skeleton published earlier the structure of the Y amino acid as 3-(2-chlor-4-seryl-phenoxy)-5-(4-seryl-phenoxy)-p-hydroxyphenylglycine was suggested. The presence of 2 alcoholic groups of the phenylserine fragments of the Y amino acid in the actinoidine aglycone was shown with additional acetylation (Ac2O/Py) of N-acetylmethoxyaglycone. It was found with O-acetylation of N-acetylmethoxyactinosaminyl aglycone that the actinosamine amino sugar in the actinoidine molecule was bound with one of the above groups.
D000107:Acetylation; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002854:Chromatography, Paper; D004578:Electron Spin Resonance Spectroscopy; D006868:Hydrolysis; D013056:Spectrophotometry, Ultraviolet; D014233:Tricarboxylic Acids / Q000032:analysis*; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000032:analysis
D000900:Anti-Bacterial Agents; D014233:Tricarboxylic Acids; C012164:actinoidins; D014640:Vancomycin
Stroenie trekh"iadernoĭ triaminotrikarbonovoĭ kisloty (Y) iz antibiotika aktinoidina.