title: Melatonin and corticosteroid response to metyrapone in patients with pituitary disease.
abstract: Melatonin secretion is dependent both on the environmental lighting and noradrenergic control and seems to be related to the ACTH-cortisol secretion. The aim of the present study was to further elucidate the relationship between ACTH-cortisol and melatonin. For this purpose we chose the Metyrapone test. The melatonin secretion was studied in 10 patients, and increased significantly in 8/10 during and in one after the Metyrapone administration. These results further support a relationship between melatonin and ACTH-cortisol secretion, possibly through a suprapituitary interaction.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008797:Metyrapone / Q000494:pharmacology*; D008875:Middle Aged; D010870:Pineal Gland / Q000502:physiology; D010900:Pituitary Diseases / Q000503:physiopathology*
chemical_list: D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D008550:Melatonin; D006854:Hydrocortisone; D008797:Metyrapone