Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Sprague-Dawley rats were used to further characterize the anorexic action of orally-administered THIP, a GABA-analogue. The anorexic action of THIP (5 or 10 mg/kg) was antagonized by prior subcutaneous injection of bicuculline (1 mg/kg), but not by prior subcutaneous injection of bicuculline-methobromide (1.5 mg/kg), strychnine-SO4 (0.75 mg/kg), pentylenetetrazol (25 mg/kg), or picrotoxin (1 mg/kg). Orally-administered GABA (50-300 mg/kg), bicuculline (1-10 mg/kg) or picrotoxin (1-10 mg/kg) generally did not inhibit food intake. These results indicate that the anorexic action of THIP is mediated by central GABA-receptors.
D000284:Administration, Oral; D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011963:Receptors, GABA-A; D013331:Strychnine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D001640:Bicuculline; D007555:Isoxazoles; D010080:Oxazoles; D010433:Pentylenetetrazole; D010852:Picrotoxin; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D013331:Strychnine; D005680:gamma-Aminobutyric Acid; C036615:bicuculline methobromide; C015542:gaboxadol