Electrostatic potential molecular surfaces.
Color-coded computer graphics representations of the electrostatic potentials of trypsin, trypsin-inhibitor, prealbumin and its thyroxine complex, fragments of double-helical DNA, and a netropsin--DNA complex illustrate the electrostatic and topographic complementarity in macromolecule-ligand interactions. This approach is powerful in revealing intermolecular specificity and shows promise of having predictive value in drug design.
D003201:Computers; D008024:Ligands; D008958:Models, Molecular; D009429:Netropsin; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids; D011228:Prealbumin; D011487:Protein Conformation; D012709:Serum Albumin; D013963:Thyroid Hormones; D014357:Trypsin; D014359:Trypsin Inhibitor, Kazal Pancreatic
D008024:Ligands; D009696:Nucleic Acids; D011228:Prealbumin; D012709:Serum Albumin; D013963:Thyroid Hormones; D014359:Trypsin Inhibitor, Kazal Pancreatic; D009429:Netropsin; D014357:Trypsin