Excitatory effects of ACTH on noradrenergic neurons of the locus coeruleus in the rat.
Responses of presumed noradrenaline-containing neurons in locus coeruleus (LC) to iontophoretically applied ACTH were determined. The full sequence ACTH1-39 and the partial sequence ACTH1-24 were excitatory on the majority of neurons tested. The partial sequence ACTH27-39 was without effect on most neurons. The presence of ACTH-containing fibers in LC together with the present results may suggest a controlling influence of the peptide on the noradrenaline system.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003366:Cosyntropin / Q000494:pharmacology; D004553:Electric Conductivity; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D010446:Peptide Fragments; D003366:Cosyntropin; C036300:ACTH (27-39); D000324:Adrenocorticotropic Hormone; D009638:Norepinephrine