Simultaneous simulation of the serum profiles of two antibiotics and analysis of the combined effect against a culture of Pseudomonas aeruginosa.
The serum profiles of ceftriaxone (CEF) and netilmicin (NET) were produced in a liquid culture of Pseudomonas aeruginosa, and the change in viable count recorded. Synergism was detectable between CEF and NET despite of the widely disparate serum halflife times of NET and CEF.
D000900:Anti-Bacterial Agents / Q000097:blood / Q000494:pharmacology*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002443:Ceftriaxone; D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D009428:Netilmicin / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin; D002443:Ceftriaxone; D002439:Cefotaxime