Regulation of uterine smooth muscle bradykinin receptors by bradykinin levels and angiotensin converting enzyme inhibitor in the rat.
1. Bradykinin infusion (0.1 microgram/min i.v.) decreased the number of uterine bradykinin receptors by 20% at Day 2. Bradykinin receptors returned to control levels at Day 7. 2. Captopril infusion (1.7 micrograms/min i.v.) induced prolonged decreases in the number of uterine bradykinin receptors of 15% at Day 2 and of 13% at Day 7, respectively. 3. The number of uterine bradykinin receptors was increased in two-kidney, one clip hypertensive rats by 19%. 4. These results suggest that endogenous bradykinin participates in the regulation of uterine bradykinin receptors. 5. Decreased uterine bradykinin receptors induced by captopril might reflect increased endogenous bradykinin.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000378:metabolism* / Q000494:pharmacology; D002216:Captopril / Q000494:pharmacology; D005260:Female; D009130:Muscle, Smooth / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000502:physiology*; D014599:Uterus / Q000033:anatomy & histology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D011955:Receptors, Drug; D002216:Captopril; D001920:Bradykinin