beta-Adrenergic, CRF-ergic and dopaminergic mechanisms controlling alpha-MSH secretion in rat pars intermedia cells in primary culture.
1. A pure population of pars intermedia cells in primary culture was used to study changes in alpha-MSH secretion and cyclic AMP accumulation. 2. Beta-adrenergic agonists and CRF (corticotropin-releasing factor) stimulate alpha-MSH secretion and cyclic AMP accumulation. 3. Dopaminergic agonists inhibit basal as well as (-)isoproterenol- and CRF-induced alpha-MSH secretion and cyclic AMP accumulation. 4. Beta-adrenergic, dopaminergic and CRF receptors regulate pars intermedia cell activity probably through the adenylate cyclase system.
D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000818:Animals; D053497:Corticotropin-Like Intermediate Lobe Peptide; D046508:Culture Techniques; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D010446:Peptide Fragments / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*
D010446:Peptide Fragments; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D011954:Receptors, Dopamine; D053497:Corticotropin-Like Intermediate Lobe Peptide; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D000242:Cyclic AMP