[Neuromuscular transmission troubles in a case of acute lithium intoxication (author's transl)].
In the course of an acute intoxication by lithium, neuromuscular junction has been tested by 1 sec bursts of repetitive stimulation. Recorded data concern: (1) inhibition of acetylcholine synthesis, at the time of high seric rates; (2) exhibition, at rather lower concentrations, of two types of potentiation: a primary, moderate potentiation, high frequency-sensitive (30 or 50 HZ), and a more lasting cumulative potentiation, enhancing the post-tetanic potentiation by nearly 300%. Results are compared with some of the neurophysiological data in the literature.
D000328:Adult; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008094:Lithium / Q000009:adverse effects* / Q000378:metabolism; D016651:Lithium Carbonate; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000503:physiopathology*; D009435:Synaptic Transmission
D016651:Lithium Carbonate; D008094:Lithium
Troubles de la transmission neuromusculaire dans un cas d'intoxication aiguë au lithium.