Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalized phosphatidic acid formation.
D000118:Acetylglucosaminidase / Q000097:blood; D000244:Adenosine Diphosphate / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D006629:Hirudins / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D010712:Phosphatidic Acids / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000502:physiology*; D018179:Receptors, Thrombin; D012701:Serotonin / Q000097:blood; D013917:Thrombin / Q000502:physiology*
D001095:Arachidonic Acids; D006629:Hirudins; D010712:Phosphatidic Acids; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin; D016718:Arachidonic Acid; D012701:Serotonin; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000118:Acetylglucosaminidase; D013917:Thrombin; D002118:Calcium