A T-cell line derived from normal human cord leukocytes by co-culturing with human leukemic T-cells.
A unique T-cell line, MT-2, was established from normal human cord leukocytes of a male infant by co-culturing with leukemic T-cells from a female patient with adult T-cell leukemia. MT-2 cells expressed receptors for sheep erythrocytes and complement and were reactive with anti-T-cell and anti-Ia sera. They were negative for Fc receptors, surface immunoglobulin, and Epstein-Barr virus nuclear antigen. Chromosomally, the MT-2 line was male and most cells were shown to have a normal diploid karyotype. The cultured cells were tumorigenic when transplanted into immunosuppressed newborn hamsters.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002478:Cells, Cultured; D006224:Cricetinae; D005260:Female; D005312:Fetal Blood; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007938:Leukemia; D008297:Male; D008875:Middle Aged; D009374:Neoplasms, Experimental / Q000209:etiology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D011951:Receptors, Complement / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis; D013601:T-Lymphocytes
D000956:Antigens, Viral; D011947:Receptors, Antigen, B-Cell; D011951:Receptors, Complement; D011961:Receptors, Fc