title: A note on synthesis and reactivity towards DNA of glycidonitrile, the epoxide of acrylonitrile.
abstract: Different ways have been used to synthesize glycidonitrile, the epoxide of acrylonitrile. The reaction product has been characterized by n.m.r. spectroscopy. While glycidonitrile-induced strand breaks in SV40 phage DNA in vitro, acrylonitrile did not.
mesh_terms: D000181:Acrylonitrile / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects; D004279:DNA, Viral / Q000235:genetics*; D004852:Epoxy Compounds; D005027:Ethylene Oxide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009570:Nitriles / Q000494:pharmacology; D013539:Simian virus 40 / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D004279:DNA, Viral; D004852:Epoxy Compounds; D009570:Nitriles; C033154:2-cyanoethylene oxide; D005027:Ethylene Oxide; D000181:Acrylonitrile