[A disseminated form of Histoplasma duboisii histoplasmosis in a Zaïre patient (author's transl)].
Report of a case of histoplasmosis observed in Zaïre with lymphatic, pulmonary and intestinal localizations. Histoplasma duboisii was abundant in the stools, sputum and lymphatic tissue. With no amphotericine B available, treatment first started with high dosage of miconazole which had no effect. Ketoconazole have been, then, tried, giving a clinical and biological improvement, but patient still in a very bad condition, died. Ketoconazole seems to have a rapid but not lasting effect, even with increased dosages.
D000328:Adult; D015023:Democratic Republic of the Congo; D006660:Histoplasmosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007654:Ketoconazole; D008297:Male; D008825:Miconazole / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use
D007093:Imidazoles; D010879:Piperazines; D008825:Miconazole; D007654:Ketoconazole
Forme disséminée d'histoplasmose à Histoplasma duboisii chez un Zairois.