title: Calmodulin: an overview.
abstract: Calmodulin is a 16,700-dalton Ca2+-binding protein ubiquitous in the eukaryotes. It has no intrinsic enzymatic activity, but it regulates a wide spectrum of enzymes that control many basic cellular processes, ranging from the metabolism of cyclic nucleotides, Ca2+, and glycogen to contractile activity and stimulus-secretion coupling. Mounting evidence now indicates that calmodulin is the major intracellular Ca2+ receptor that remained elusive despite three decades of extensive work by many investigators.
mesh_terms: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000595:Amino Acid Sequence; D000779:Anesthetics, Local / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology*; D002417:Cattle; D000242:Cyclic AMP / Q000502:physiology; D010640:Phenothiazines / Q000378:metabolism; D011487:Protein Conformation; D014268:Trifluoperazine / Q000378:metabolism
chemical_list: D000779:Anesthetics, Local; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D010640:Phenothiazines; D014268:Trifluoperazine; D000242:Cyclic AMP; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D002118:Calcium