Effect of PGE1 on PGF2 alpha-induced luteolysis in nonbred ewes.
Fifty-six ewes were used to study the effects of PGE1 or PGE2 plus PGF2 alpha given into the perivascular space of the ovarian vascular pedicle on luteal function of nonbred ewes. All ewes receiving PGF2 alpha had reduced levels of plasma progesterone and unoccupied receptors for LH at 24 hr after treatment regardless even if they received PGE1 or PGE2 concomitantly. Levels of plasma progesterone in ewes receiving only PGF2 apha were reduced further at 48 hour. Plasma progesterone and unoccupied receptors for LH of ewes receiving PGE2 + PGF2 alpha were maintained at 48 hr at levels seen at 24 hr after treatment, while progesterone in ewes receiving PGE1 + PGF2 alpha at 48 hr returned to levels seen in controls at 48 hr and unoccupied receptors for LH were three fold greater than controls.
D000527:Alprostadil; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects*; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D009929:Organ Size / Q000187:drug effects; D011374:Progesterone / Q000097:blood; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism; D011974:Receptors, LH; D012756:Sheep / Q000502:physiology*
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011956:Receptors, Cell Surface; D011974:Receptors, LH; D011374:Progesterone; D015237:Dinoprost; D000527:Alprostadil; D015232:Dinoprostone