Isolated thyrotropin deficiency in a man with narcoleptic attacks.
A patient with narcoleptic attacks and isolated thyrotropin deficiency is presented. Substitution with l-thyroxine did not relieve his narcoleptic attacks. Deficiency, in the central nervous system, of the ergotropic substance thyrotropin-releasing hormone (TRH) might have caused the thyrotropin deficiency and contributed to the narcoleptic attacks. However, prolonged oral medication with TRH, in doses of 120 or 240 g daily, failed to attain any significant relief. Although this does Not exclude TRH unresponsiveness due to absent or defective TRH receptors, the true cause of the disease remains to be elucidated.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000097:blood* / Q000188:drug therapy; D011388:Prolactin / Q000097:blood; D011956:Receptors, Cell Surface / Q000187:drug effects; D018025:Receptors, Thyrotropin-Releasing Hormone; D013972:Thyrotropin / Q000172:deficiency*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013974:Thyroxine / Q000627:therapeutic use
D011956:Receptors, Cell Surface; D018025:Receptors, Thyrotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone; D013974:Thyroxine