Mitochondrial NADH dehydrogenase-catalyzed oxygen radical production by adriamycin, and the relative inactivity of 5-iminodaunorubicin.
D000818:Animals; D002417:Cattle; D003579:Cytochrome Reductases / Q000378:metabolism*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D005609:Free Radicals; D008929:Mitochondria, Heart / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D012402:Rotenone / Q000494:pharmacology; D013367:Submitochondrial Particles / Q000201:enzymology; D013481:Superoxides / Q000378:metabolism*
D005609:Free Radicals; D012402:Rotenone; D013481:Superoxides; D004317:Doxorubicin; D003579:Cytochrome Reductases; D009245:NADH Dehydrogenase; C018979:5-iminodaunorubicin; D010100:Oxygen; D003630:Daunorubicin