Calcium pyrophosphate dihydrate deposition disease and familial hypomagnesemia.
A 40-year-old woman presented with calcium pyrophosphate synovitis and chondrocalcinosis. She was subsequently found to have hypomagnesemia, as did her 22-year-old son. Metabolic studies demonstrated normal gastrointestinal absorption of magnesium, and impaired renal conservation of magnesium without other evidence of renal tubular dysfunction. It seems likely that a genetically determined abnormality of magnesium metabolism was responsible for the occurrence of chondrocalcinosis in this patient.
D000328:Adult; D002118:Calcium / Q000378:metabolism; D002131:Calcium Pyrophosphate / Q000502:physiology*; D002805:Chondrocalcinosis / Q000150:complications; D003460:Crystallization; D004064:Digestive System / Q000378:metabolism; D011756:Diphosphates / Q000502:physiology*; D005260:Female; D006801:Humans; D008274:Magnesium / Q000378:metabolism; D008275:Magnesium Deficiency / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D013585:Synovitis / Q000150:complications
D011756:Diphosphates; D008274:Magnesium; D002118:Calcium; D002131:Calcium Pyrophosphate