Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats.
Antibodies were raised in rats against the poliovirus type 1 capsid proteins, VP1, VP2, and VP3. Antibodies directed against VP1 from type 1 poliovirus (Mahoney) neutralized type 1 but not type 2 poliovirus. Antibodies raised against VP2 and VP3 failed to neutralize type 1 virus. Thus, VP1 appears to be a neutralizing antigen for poliovirus and in its denatured form presents to the immune system its neutralizing determinants.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D002213:Capsid / Q000276:immunology; D017955:Poliovirus / Q000276:immunology*; D051381:Rats; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines
D000914:Antibodies, Viral; D000956:Antigens, Viral; D014764:Viral Proteins; D014765:Viral Vaccines