title: New findings concerning the pathogenesis of acute carbon monoxide (CO) poisoning.
abstract: The pathomechanism of carbon monoxide (CO) poisoning was studied by means of cardiopathological and neuropathological investigations in experimental CO intoxication. It has been shown that besides CO-hemoglobin association, the binding of CO to cytochromes is a significant factor. The latter is thought to be responsible for the cytotoxic phenomena. Combined ultrastructural and cytochemical studies have enabled differentiation between toxic, hypoxic, and mixed alternations.
mesh_terms: D000208:Acute Disease; D000262:Adenylyl Cyclases / Q000032:analysis; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000648:ultrastructure; D002249:Carbon Monoxide Poisoning / Q000473:pathology*; D004195:Disease Models, Animal; D003576:Electron Transport Complex IV / Q000032:analysis; D006651:Histocytochemistry; D008854:Microscopy, Electron; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure; D009940:Organoids / Q000648:ultrastructure; D051381:Rats; D013385:Succinate Dehydrogenase / Q000032:analysis
chemical_list: D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D000262:Adenylyl Cyclases