Effects of vasopressin, noradrenalin and oxytocin on blood flow distribution in rat kidney with neoplasm.
The arterial blood flow distribution between tumour and intact renal tissue was investigated in rats with transplanted sarcomas. Changes in tissue flow were measured by the microsphere tracer technique, and the redistributing effects on blood flow of vasopressin, noradrenalin and oxytocin was recorded. Bolus injections of vasopressin gave a transient decrease of intact tissue flow, not found in tumours. At increasing doses of vasopressin and in early tumour growth phase, the flow discriminating effect tended to vanish. Constant intravenous infusion of vasopressin gave similar reduction of flow in tumour and intact tissue. Selective administration into the renal artery reduced flow in intact tissue but produced ambiguous effects in tumour tissue. Noradrenalin produced less reduction of tumour flow as compared with intact tissue flow. Oxytocin increased tumour blood flow while no flow change occurred in intact tissue. Oxytocin thus appeared to produce the most favourable redistribution of flow within tumour kidneys for the prospect of conveying cytotoxic agents selectively to the tumour.
D000818:Animals; D005260:Female; D007668:Kidney / Q000098:blood supply*; D007680:Kidney Neoplasms / Q000098:blood supply*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012513:Sarcoma, Experimental / Q000098:blood supply; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D010121:Oxytocin; D009638:Norepinephrine