Resistance to Moloney murine sarcoma virus (M-MuSV) tumor induction is associated with natural antibody production to "endogenous" Moloney leukemia virus (M-MuLV) in BALB/Mo mice.
BALB/Mo mice are characterized by early expression of "endogenized" M-MuLV and are resistant to M-MuSV tumor induction. Furthermore, compared to normal BALB/c mice, sera from BALB/Mo mice exhibit a significant reactivity which is specific for M-MuLV when tested in a 125I-labelled Staphylococcus protein A binding assay. The possible significance of this reactivity in conferring tumor resistance is explored.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D002472:Cell Transformation, Viral; D007113:Immunity, Innate; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000276:immunology; D009053:Sarcoma Viruses, Murine / Q000276:immunology; D013997:Time Factors; D014412:Tumor Virus Infections / Q000276:immunology*; D014775:Virus Activation
D000914:Antibodies, Viral