Development of morphine-induced changes of activity in the mouse.
The development of spontaneous activity in response to morphine administration was studied at different postnatal ages in C57BL/6 mice. Morphine induced hyperactivity at all ages except in 3-week-old mice, in which a catatonic effect is evident. The results indicate that the neurophysiological and inhibitory systems responsible for the non-analgesic effects of morphine are not characterized by the same developmental pattern.
D000375:Aging; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011957:Receptors, Opioid / Q000187:drug effects
D011957:Receptors, Opioid; D009020:Morphine