title: Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes.
mesh_terms: D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000235:genetics*; D002460:Cell Line; D004273:DNA, Neoplasm / Q000235:genetics; D004351:Drug Resistance; D005784:Gene Amplification; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics*; D008727:Methotrexate / Q000627:therapeutic use*; D009154:Mutation
chemical_list: D004273:DNA, Neoplasm; D008727:Methotrexate