[Trial of polyguacyl safety and tolerance].
The results of studies of the antiviral and interferon-inducing activity of the synthetic interferon inducer polyguacyl in white mice as well as the results of the study of safety and tolerance of this drug given to human subjects as aerosol and intranasally are presented. Both modes of administration to mice induced production of endogenous interferon, although after intranasal inoculation high interferon titres in the blood serum of the animals were observed for longer periods of time, whereas after aerosol administration interferon disappeared more rapidly. Significant antiviral protection was achieved only by the intranasal administration of the inducer resulting in 84.0% survival of the animals challenged with the mouse-adapted influenza A/Aichi virus. Clinical trials of polyguacyl in human volunteers demonstrated the safety and good tolerance of this drug given both as aerosol and intranasally.
D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004361:Drug Tolerance; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D051379:Mice; D011066:Poly C / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D011068:Poly G / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D011131:Polyribonucleotides / Q000633:toxicity*; D013997:Time Factors; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000336:Aerosols; D007369:Interferon Inducers; D011131:Polyribonucleotides; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C
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