Sendai virus-specific T cell clones II. Induction of interferon production by Sendai virus-specific T helper cell clones.
Interferon (IFN) was detected upon co-culture of cloned Sendai virus (SV)-specific T lymphocyte with SV-presenting syngeneic stimulator cells. The antiviral activity was defined as IFN-alpha, beta. The T cell clones, upon contact with antigen-presenting stimulator cells, stimulated adherent cells present in the stimulator cell population to secrete IFN. Induction of IFN production was independent from interleukin 2 production by the T cell clones.
D000818:Animals; D002448:Cell Adhesion; D002999:Clone Cells / Q000276:immunology; D005260:Female; D007370:Interferon Type I / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D007370:Interferon Type I