title: Effects of fowlpox virus infection on lipid metabolism in cultured chicken embryo cells.
abstract: Lipid biosynthesis was measured in cultured chicken embryo cells after infection with fowlpox virus. Between 24 and 72 h postinfection, fowlpox virus-infected cells incorporated less [14C]acetate and 3H2O into fatty acids and sterols than did mock-infected cells, demonstrating a virus-dependent inhibition of general lipid metabolism. Two specific effects of fowlpox virus infection were an accumulation of C-4 alkylated sterol intermediates and inhibition of monounsaturated fatty acid biosynthesis.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D002784:Cholesterol / Q000096:biosynthesis*; D005227:Fatty Acids / Q000096:biosynthesis*; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis; D005587:Fowlpox virus / Q000502:physiology*; D007700:Kinetics; D050356:Lipid Metabolism; D011212:Poxviridae / Q000502:physiology*; D013261:Sterols / Q000096:biosynthesis
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D013261:Sterols; D002784:Cholesterol