[Osteodystrophy in children with chronic renal insufficiency in dialysis therapy].
One of the most important complication of patients with chronic renal failure is osteodystrophy. This causes skeletal deformities, growth failure, bone pain and decreased physical activity. Osteodystrophy is more frequent among children than uraemic adults. In fact, 50-80% of children with chronic renal failure may occur in metabolic bone disease and the incidence tends to be higher in those children who have been in uraemic state for a long time before starting chronic haemodialysis. Osteodystrophy is a result of: 1) lesions of rickets; 2) lesions of osteitis fibrosa: 3) osteosclerosis. In contrast to adult, metastatic calcifications are virtually never observed in uraemic children. Hyperphosphoraemia, that is secondary to the reduction of G.F.R., may be the principal responsible of hyperparathyroidism that is the main cause of osteodystrophy. Hyperparathyroidism is also maintained and increased by deficit of 1,25(OH)2D3 which is responsible for lesions of rickets. Haemodialysis may markedly improve osteitis fibrosa and it is efficacious in reversing the mineral defect. Dialysate calcium concentration should be maintained at approximately 3,5 mEq/l. In this case we can raise serum calcium. On the contrary dialysate has to be lacking in phosphorus to correct hyperphosphoraemia. It must be noted that we have to prepare a dialysate with deionized water lacking in aluminum to avoid encephalopathy compliance.
D000536:Aluminum Hydroxide / Q000627:therapeutic use; D002112:Calcifediol; D002117:Calcitriol / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D002648:Child; D002762:Cholecalciferol / Q000627:therapeutic use; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications*; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis; D014807:Vitamin D / Q000627:therapeutic use
D006887:Hydroxycholecalciferols; D014807:Vitamin D; D002762:Cholecalciferol; D010758:Phosphorus; D000536:Aluminum Hydroxide; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium
Osteodistrofia nel bambino con insufficienza renale cronica in trattamento dialitico.