Epstein-Barr virus in normal pregnant women.
Acquired immune suppression accompanying normal pregnancy may be associated with reactivation of Epstein-Barr virus (EBV). Pregnant women with reactivated EBV having anti-EA antibodies show high titers of antiviral capsid antigen (VCA) geometric mean titers (GMT) of 522 versus 170 in those lacking anti-early antigen (EA). Among twenty-seven seropositive women at parturition, 17 (63%) had generated antibody to EA, and all 27 (100%) demonstrated significant increases in antibody to VCA (p less than 0.01). In contrast, antibody titers to cytomegalovirus, herpes hominis, varicella-zoster, and rubella viruses in the pregnant women were comparable to those found in nonpregnant controls. (Am J Reprod Immunol. 1982; 2:217-221.)
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D000937:Antigen-Antibody Reactions; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D011247:Pregnancy; D012412:Rubella virus / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D014775:Virus Activation
D000914:Antibodies, Viral