Modulation of the histamine-induced inhibitory response in an identified Onchidium neuron by cyclic nucleotides.
Intrinsic beating activity in the identified molluscan neuron Be-1 can be inhibited for a relatively long time by a short application of histamine. Cyclic AMP enhanced both the amplitude and duration of this inhibitory histamine response (H2-response), while cyclic GMP depressed the H2-response. However, when only these nucleotides were applied, they produced no significant, change in the beating spike activity.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D005724:Ganglia / Q000166:cytology; D006632:Histamine / Q000494:pharmacology*; D008974:Mollusca; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D003995:Dibutyryl Cyclic GMP; D003994:Bucladesine; D006632:Histamine; D000242:Cyclic AMP; D006152:Cyclic GMP