Intrinsic actions of benzodiazepine antagonists.
RO 15-1788 (4-20 mg/kg), both alone and in combination with chlordiazepoxide (5 mg/kg), increased exploratory head-dipping in an holeboard above control levels. This intrinsic action of a benzodiazepine antagonist is not reversed, and is even augmented, by chlordiazepoxide. RO 15-1788 alone had no effect on locomotor activity, but antagonized the sedative effects of chlordiazepoxide. beta-CCE (1 and 2 mg/kg) was without effect on locomotor activity, but the higher dose reduced head-dipping.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002243:Carbolines / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects*; D005442:Flumazenil; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009115:Muridae; D011955:Receptors, Drug / Q000187:drug effects*; D011963:Receptors, GABA-A
D001570:Benzodiazepinones; D002243:Carbolines; D007211:Indoles; D011955:Receptors, Drug; D011963:Receptors, GABA-A; D005442:Flumazenil; D002707:Chlordiazepoxide; C024915:beta-carboline-3-carboxylic acid ethyl ester