Experimental maedi virus infection in sheep: early cellular and humoral immune response following parenteral inoculation.
The early immune response (19 weeks) in sheep inoculated parenterally with maedi virus was studied, using the lymphocyte transformation test, immunodiffusion test, complement-fixation test, and neutralization test. Cellular immune responses were detected between 3 and 7 weeks after the sheep were inoculated. Antibodies were detected by immunodiffusion test in 3 of 5 animals in weeks 7 to 11 and by complement-fixation test in weeks 15 to 19. Neutralizing antibodies were not detected. There was no sign of virus-induced immunosuppression as determined by lymphocyte responsiveness to mitogens or by in vivo and in vitro immune responses following BCG vaccination.
D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008934:Mitogens / Q000494:pharmacology; D011021:Pneumonia, Progressive Interstitial, of Sheep / Q000276:immunology*; D012756:Sheep; D013997:Time Factors; D014790:Visna-maedi virus / Q000276:immunology
D001500:BCG Vaccine; D008934:Mitogens