Effects of benzo(a)pyrene on Friend viral leukemogenesis in B10SJF1 mice.
A single intraperitoneal injection of benzo(a)pyrene (BP) given 1, 2, or 3 days before an ip injection of Friend leukemia virus (FLV) significantly increased the leukemogenic effect of the virus in B10SJF1 mice. These hybrids are the offspring of C57BL/10 females and SJL/J males and are highly resistant to FLV leukemogenesis when the virus is injected alone.
D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D003433:Crosses, Genetic; D005260:Female; D005622:Friend murine leukemia virus / Q000187:drug effects / Q000235:genetics; D007942:Leukemia, Experimental / Q000382:microbiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D001580:Benzopyrenes; D002273:Carcinogens; D001564:Benzo(a)pyrene