[Structural reconstruction of chemo-sensitive biomembranes during the action of low molecular weight compounds using spin resonance].
Using the spin probe technique, the changes in the supramolecular structure of the central nervous system synaptic membranes and of olfactory hair membranes of Rana temporaria induced by low molecular weight organic substances of different chemical nature, were investigated. It was found that the membrane structures under study differ considerably in their sensitivity to chemical stimulation and in temporal kinetics of structural transitions. A correlation between physiological parameters of olfactory perception of the compounds used and the parameters of structural transitions in olfactory hair membranes was established. The interrelationship between the experimental data and chemoreception of odorants and mediators as well as the applicability of these preparations for membrane screening of biologically active substances are discussed.
D000818:Animals; D001921:Brain / Q000648:ultrastructure; D004578:Electron Spin Resonance Spectroscopy; D008566:Membranes / Q000648:ultrastructure*; D011896:Rana temporaria; D013113:Spin Labels; D013570:Synaptic Membranes / Q000648:ultrastructure*
D013113:Spin Labels
Issledovanie strukturnykh perestroek khemochuvstvitel'nykh biomembran pri deĭstvii nizkomolekuliarnykh soedineniĭ metodom spinovogo zonda.