title: Effect of chronic ethanol consumption on central and peripheral type benzodiazepine binding sites in the mouse brain.
abstract: Following chronic exposure of C57/BL6 mice to ethanol the binding of [3H]Ro5-4864 and [3H]propyl-beta-carboline-3-carboxylate to benzodiazepine binding sites in the brain was studied. Peripheral-type benzodiazepine binding sites were measured using the probe [3H]Ro5-4864. Chronic ethanol treatment resulted in a significant increase in [3H]Ro5-4864 binding due to a 43% increase in receptor density. The affinity of [3H]Ro5-4864 for the receptor was not significantly affected. The binding of [3H]propyl-beta-carboline-3-carboxylate to central-type benzodiazepine receptors was not affected by chronic ethanol treatment.
mesh_terms: D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism*; D001570:Benzodiazepinones / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D011963:Receptors, GABA-A
chemical_list: D001570:Benzodiazepinones; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D001569:Benzodiazepines; C028513:4'-chlorodiazepam; D000431:Ethanol