Effects of pH on the activity of ketoconazole against Candida albicans.
The activity of ketoconazole against Candida albicans in Sabouraud glucose medium was markedly influenced by pH. Minimum inhibitory concentrations of this imidazole against both a standard strain and clinical isolates ranged from 40 mug/ml at pH 3 to 0.02 mug/ml at pH 7, a greater than 1,000-fold difference.
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology*; D007654:Ketoconazole; D010879:Piperazines / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; D007093:Imidazoles; D010879:Piperazines; D007654:Ketoconazole