Role of the spleen in the pathogenesis of experimentally induced bovine leukemia virus infection.
In an extension of a previous pathogenesis study, bone marrow and other tissues from four experimentally inoculated cattle were tested for virus between the 13th and 20th days after experimental inoculation with bovine leukemia virus. BLV was detected in the blood of three, spleen of two, lymph node of two and bone marrow of only one of the inoculated cattle. In additional studies, four splenectomized and two intact control calves were also examined. Two of these calves were splenectomized before BLV inoculation and two after a persistent virus infection had been established. Results indicated that the removal of the spleen affected neither the establishment and persistence of virus infection nor the development and maintenance of serological responses to viral antigens.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001853:Bone Marrow / Q000382:microbiology; D002417:Cattle; D001909:Leukemia Virus, Bovine / Q000276:immunology / Q000302:isolation & purification; D007942:Leukemia, Experimental / Q000382:microbiology / Q000503:physiopathology*; D008198:Lymph Nodes / Q000382:microbiology; D013154:Spleen / Q000382:microbiology / Q000503:physiopathology*; D013156:Splenectomy; D014766:Viremia
D000914:Antibodies, Viral