title: Gratuitous induction by N-acetylmannosamine of germ tube formation and enzymes for N-acetylglucosamine utilization in Candida albicans.
abstract: N-Acetylmannosamine did not support the growth of Candida albicans, and this sugar was not accumulated by cells. Incubation of starved yeast cells at 37 degrees C with N-acetylmannosamine plus glucose resulted in germ tube formation. Furthermore, N-acetylmannosamine alone induced the uptake system for N-acetylglucosamine and the enzymes of the N-acetylglucosamine catabolic pathway to the same extent as the natural substrate. Induction of the uptake system and the enzymes was observed at 28 degrees C without germ tube formation and at 37 degrees C with germ tube formation. N-Acetylmannosamine is thus a gratuitous inducer for enzymes of the N-acetylglucosamine pathway and germ tube formation in C. albicans.
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D019747:Aldose-Ketose Isomerases; D000581:Amidohydrolases / Q000096:biosynthesis; D002176:Candida albicans / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D002238:Carbohydrate Epimerases / Q000096:biosynthesis; D004790:Enzyme Induction; D005944:Glucosamine / Q000031:analogs & derivatives*; D006595:Hexosamines / Q000494:pharmacology*; D010770:Phosphotransferases / Q000096:biosynthesis; D017853:Phosphotransferases (Alcohol Group Acceptor)
chemical_list: D006595:Hexosamines; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C018716:N-acetylglucosamine kinase; D000581:Amidohydrolases; C018717:N-acetylglucosamine-6-phosphate deacetylase; C020582:glucosamine-6-phosphate isomerase; D002238:Carbohydrate Epimerases; D019747:Aldose-Ketose Isomerases; D005944:Glucosamine; D000117:Acetylglucosamine; C002022:N-acetylmannosamine