Intermittent stimulation with LH-RH in postmenopausal hypergonadotropism.
Ten postmenopausal women received 8 consecutive (1 hour interval) i.v. bolus injections of either 25 or 500 micrograms of LH-RH. Gonadotropin release was monitored before and during LH-RH stimulation. After the first LH-RH bolus a dose-dependent LH release was seen. All consecutive LH-RH boli elicited similar LH responses resulting in pulse-type LH release. Throughout the whole stimulation period the pituitary gland remained highly responsive to LH-RH, FSH release was uncharacteristic. It is concluded that during postmenopause LH-RH is hyper-secreted. Thus the pituitary gland remains responsive to repeated injections of even supraphysiological LH-RH doses.
D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause; D008875:Middle Aged; D010053:Ovary / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology*
D004966:Estrogens, Conjugated (USP); D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone