beta-Endorphin: synthesis and properties of human beta-endorphin-(1--28) and its analogs.
Three analogs of human beta-endorphin (beta h-EP) were synthesized by the solid-phage method: beta h-EP-(1--28) (I). [Gln8]-beta h-EP-(1--28) (II), and [D-Ala2, Gln8]-beta h-EP-(1--28) (III). Radioreceptor binding assay with use of tritiated beta h-EP as primary ligand gave relative potencies as follows: beta h-EP, 100; I, 85; II, 380; III, 146. Relative potencies in an analgesic assay were: beta h-EP; 100; I, 18; II, 36; III, 13.
D000595:Amino Acid Sequence; D000698:Analgesia; D000818:Animals; D001681:Biological Assay; D001921:Brain / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004723:Endorphins / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D051379:Mice; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism; D013329:Structure-Activity Relationship
D004723:Endorphins; D007202:Indicators and Reagents; D011957:Receptors, Opioid