[Onset of effect of an i.v. ranitidine bolus].
Ranitidine 50 mg or 0.9% saline was given i.v. to 12(6) volunteers and pH and volume of the gastric aspirate was measured in short-time intervals over a period of 6 hours. There was an increase in pH above 4 in all subjects starting within 30 min after ranitidine injection. Concomitantly volume secretion was reduced to 35-50%. i.v. administration of ranitidine 30-45 min before induction of anaesthesia should, therefore, reduce the number of patients theoretically at risk of acid-induced pulmonary damage.
D000328:Adult; D005663:Furans / Q000008:administration & dosage / Q000494:pharmacology*; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D011899:Ranitidine; D013997:Time Factors
D005663:Furans; D011899:Ranitidine
Wirkeintritt einer i.v. Ranitidin-Bolusgabe.