Warfarin binding to plasma of workers exposed to toluene diisocyanate.
The extent of [14]C-warfarin binding to plasma proteins was evaluated in a group of normal, healthy volunteers and in two groups of individuals occupationally exposed to toluene diisocyanate (TDI). Plasma binding was assessed by ultrafiltration after the addition of racemic [14]C-warfarin to a final concentration of 0.8 microgram/ml. Chronic occupational exposure to TDI did not affect the extent of warfarin binding since warfarin free fractions (normalized to an albumin concentration of 4.5 g/dl) were 1.09 +/- 0.23 (mean +/- SD), 0.98 +/- 0.19, and 0.97 +/- 0.15 for controls and the two groups of TDI-exposed individuals, respectively.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D002617:Chemical Industry; D003485:Cyanates / Q000506:poisoning*; D006801:Humans; D009784:Occupational Diseases / Q000097:blood* / Q000139:chemically induced; D011485:Protein Binding; D012408:Rubber; D014051:Toluene 2,4-Diisocyanate / Q000506:poisoning*; D014859:Warfarin / Q000097:blood*
D001798:Blood Proteins; D003485:Cyanates; D014051:Toluene 2,4-Diisocyanate; D014859:Warfarin; D012408:Rubber