Prostaglandin hyperalgesia, IV: a metabolic process.
Prostaglandin E2, prostacyclin and Db-cAMP injected into the rat paw induce hyperalgesia. This hyperalgesic effect of the prostaglandins but not of Db-CAMP was blocked by pre-treatment of the animals with cycloheximide. Prostaglandin hyperalgesia thus seems to be dependent on the triggering of some metabolic process which enhances the effects of physical or chemical stimuli.
D000818:Animals; D003994:Bucladesine; D003513:Cycloheximide / Q000494:pharmacology; D015232:Dinoprostone; D011464:Epoprostenol; D006930:Hyperalgesia / Q000139:chemically induced* / Q000503:physiopathology*; D006941:Hyperesthesia / Q000139:chemically induced* / Q000503:physiopathology*; D011453:Prostaglandins; D011458:Prostaglandins E; D051381:Rats
D011453:Prostaglandins; D011458:Prostaglandins E; D003994:Bucladesine; D003513:Cycloheximide; D011464:Epoprostenol; D015232:Dinoprostone