Receptor in group C and G streptococci detects albumin structures present in mammalian species.
The presence of albumin structures with the capacity to bind to a surface receptor in group C and G streptococci was studied in serum samples from 45 mammalian species representing 15 different orders, using an inhibition assay. The ability of animal sera to inhibit the uptake of radiolabeled human serum albumin by the streptococci indicated the presence of such albumin structures. Positive reactions were found in species of most orders tested, with Marsupialia as a notable exception. All Carnivora sera tested were strongly positive. In some orders such as Artiodactyla both positive and negative species were identified. Serum samples from 62 bird species representing 15 orders and from 5 fish species were also tested in the inhibition assay. None of these serum samples was capable of inhibiting the uptake of human serum albumin by streptococci. Some differences were also noted in the results obtained with group C and G streptococci from human and bovine sources, respectively, indicating the presence of two types of receptors. The present studies suggest a phylogenetic origin of albumin structures with affinity for the streptococcal receptor to a period after the divergence of Marsupialia from the other mammalian orders.
D000818:Animals; D001188:Artiodactyla / Q000097:blood; D002335:Carnivora / Q000097:blood; D002417:Cattle / Q000382:microbiology; D006801:Humans; D008322:Mammals / Q000097:blood*; D008394:Marsupialia / Q000097:blood; D017457:Receptors, Albumin; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012377:Rodentia / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism*; D013045:Species Specificity; D013291:Streptococcus / Q000378:metabolism*; D004490:Xenarthra / Q000097:blood
D017457:Receptors, Albumin; D011956:Receptors, Cell Surface; D012709:Serum Albumin