beta-Endorphin-induced hyperthermia in the cat.
beta-Endorphin was injected into the third cerebral ventricle (ICV) of conscious, unrestrained cats. Hyperthermic response to 50 microgram of this peptide were reduced by 20-100 microgram naloxone given ICV 1 hr later. A dose of 40 microgram beta-endorphin increased body temperature at ambient temperature of 4, 22 and 34 degrees C, with the response being greater the warmer the environment. These results indicate that beta-endorphin acts on a central naloxone-sensitive receptor which is probably the v2 receptor that is activated by low doses of D-Ala2-Met-enkephalinamide to evoke a similar pattern of change in body temperature over a comparable range of ambient temperatures.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002415:Cats; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects; D013997:Time Factors; D001615:beta-Endorphin
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D001615:beta-Endorphin