title: Angiotensin converting enzyme inhibitors.
abstract: Inhibition of angiotensin converting enzyme (ACE) in patients suffering from renovascular hypertension results in lowering of the blood-pressure. The development of captopril, an orally active ACE inhibitor and the structure-activity relationship of captopril analogues are described. Some side effects of captopril were attributed to the presence of an SH-group in the molecule. This led to the development of a series of non-mercapto ACE inhibitors derived from captopril. One of them, enalapril, a potent ACE inhibitor with a long duration of antihypertensive action, is now tested in clinical trials.
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D002216:Captopril / Q000031:analogs & derivatives / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D011817:Rabbits; D013237:Stereoisomerism
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril