title: [Effect of cytochrome c on the activity of lysosomal enzymes in the rat liver under hypobaric hypoxia].
abstract: Under conditions of three-hour hypobaric hypoxia the total activity of acid phosphatase and DNase in the rat liver somewhat lowers. The activity of free enzymes increases by 27 and 37%, and that of bound ones decreases by 42 and 24 %, respectively. Cytochrome c being introduced to hypoxic animals, the total activity of the enzymes does not significantly change. Under these conditions the activity of free acid phosphatase increases by 16%, and bound one decreases by 24 %. The activity of free acid DNase somewhat rises (by 12%) and that of bound one lowers (by 15%). A preliminary administration of cytochrome c to the organism prevents the development of pronounced changes in the activity of the studied lysosomal enzymes in the liver under grave hypoxia.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000693:Anaerobiosis; D000818:Animals; D003574:Cytochrome c Group / Q000494:pharmacology*; D003851:Deoxyribonucleases / Q000378:metabolism; D000860:Hypoxia / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D010100:Oxygen; D010313:Partial Pressure; D051381:Rats
chemical_list: D003574:Cytochrome c Group; D003851:Deoxyribonucleases; D000135:Acid Phosphatase; D010100:Oxygen
vernacular_title: Vliianie tsitokhroma c na aktivnost' fermentov lizosom v pecheni krys pri gipobaricheskoĭ gipoksii.