[Production of suppressor factor(s) in the in vitro antibody response by periodate oxidized spleen cells].
Sodium periodate treatment of Mouse spleen cells activated suppressor cells which act on the in vitro antibody response towards sheep erythrocytes or trinitrophenyl-polyacrylamide beads. Present study shows that suppression can be mediated by soluble factor (s) released in the cultures of periodate treated cells. Production of such suppressor factor (s) was associated to the presence of free aldehyde groups generated by periodate on the lymphocyte membrane. Control or cells successively treated by periodate and then reduced by borohydride were unable to produce suppressor factor (s). Suppressor factor (s) were stable at 56 degrees C (30 mn) and inactivated at 80 degrees C (10 mn).
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000276:immunology*; D007700:Kinetics; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009930:Organic Chemicals; D010504:Periodic Acid / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D007166:Immunosuppressive Agents; D009930:Organic Chemicals; C023051:suppressive factor of allergy; D010504:Periodic Acid; C009288:metaperiodate
Production de facteur(s) suppresseur(s) de la réponse anticorps in vitro par les cellules spléniques oxydées par le periodate.