Effect of sodium butyrate on the hepatoma cell cycle: possible use for cell synchronization.
Exposure of HTC cells to sodium butyrate caused inhibition of growth. The site of growth inhibition was studied by time-lapse cinematography and [3H]thymidine incorporation studies. Evidence is presented that sodium butyrate affected the cell cycle at a specific point immediately after mitosis. Inasmuch as it does not modify the interphase duration after its removal, butyrate may be used for HTC synchronization.
D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D003584:Cytological Techniques; D004247:DNA / Q000096:biosynthesis; D007399:Interphase / Q000187:drug effects; D008113:Liver Neoplasms; D008938:Mitosis / Q000187:drug effects; D051381:Rats
D002087:Butyrates; D004247:DNA