Effect of glycerol on the EP decrease caused by furosemide.
A change in endocochlear potential (EP) following furosemide injection was observed in regard to prior glycerol administration in two groups of guinea pigs. In one group, various doses of furosemide (20, 30, 40, 50 mg/kg) were injected, while in the other, glycerol (50 v/v %, 1 ml/kg) was injected prior to the furosemide (20, 30, 40 mg/kg) injection. In the glycerol-furosemide group, the decrease in EP was 40% greater than in the furosemide group. Therefore, glycerol was thought to potentiate the EP lowering action of furosemide. Such an effect of glycerol was assumed to be resulted by facilitating the access of furosemide to the site of action in the stria vascularis.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005665:Furosemide / Q000494:pharmacology*; D005990:Glycerol / Q000494:pharmacology*; D006168:Guinea Pigs; D012044:Regression Analysis; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D005665:Furosemide; D000254:Sodium-Potassium-Exchanging ATPase; D005990:Glycerol