[Oxygen, carbon dioxide and calcium control of the mechanisms of relaxation in the cerebral artery smooth musculature].
The direct action of the hypoxic (PO2 60-20 mm Hg) and hypercapnic (PCO2 50-60 mm Hg) solutions on isolated strips of human cerebral arteries was studied. Verapamil, sodium nitroprusside, manganese, dichlordiphenyltrichlomethylmethan inhibited the hypoxic and hypercapnic relaxation. The data obtained suggest that lowering of PO2 or raising of PCO2 decrease the membrane calcium transport and increase the activity of the cellular calcium pump.
D002118:Calcium / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism*; D002536:Cerebral Arteries / Q000502:physiology; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000503:physiopathology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D010100:Oxygen / Q000502:physiology*; D010101:Oxygen Consumption; D010313:Partial Pressure
D007473:Ion Channels; D002245:Carbon Dioxide; D010100:Oxygen; D002118:Calcium
Kislorod, uglekislota i kal'tsievyĭ kontrol' mekhanizmov rasslableniia v gladkoĭ muskulature arteriĭ golovnogo mozga.