EBV-positive Burkitt's lymphoma from Algeria, with a three-way rearrangement involving chromosomes 2, 8 and 9.
Burkitt's lymphoma was diagnosed in male Algerian child presenting with abdominal and jaw tumours. Viral studies revealed that this non-endemic case was associated with the Epstein-Barr virus. Cytogenetic examination of tumour cells showed a complex three-way rearrangement involving chromosomes 2, 8 and 9. Our report indicates that, in Burkitt's lymphoma, not only simple but also complex translocation involving chromosome 8 may arise. This finding in a North African case emphasizes the need for more detailed study of the clinical, virological and cytogenetic features of Burkitt's lymphoma throughout the world.
D002051:Burkitt Lymphoma / Q000235:genetics* / Q000382:microbiology; D002648:Child; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic