Effect of experimental herpes simplex virus vaccine on established ganglionic latency.
Mice were inoculated with herpes simplex virus type 1 by the corneal route beforehand. Ten weeks after the inoculation, one group of mice was repeatedly treated with infectious virus-free, detergent-soluble extract of virus-infected cells (DSE) by the intraperitoneal route and the other group served as the controls. The virus recovery rate from the trigeminal ganglia of DES-treated mice was markedly reduced as compared with that of untreated mice, when a small amount of inocula was used. However, no significant decrease in the virus recovery rate was obtained when a large amount of inocula was used, suggesting that treatment with DSE had a limited effect on established ganglionic latency. The level of neutralizing antibody titers in the serum did not seem to be correlated with the efficacy of DSE in mice infected with a small amount of inocula.
D000818:Animals; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018139:Simplexvirus / Q000276:immunology* / Q000302:isolation & purification; D012668:Trigeminal Ganglion / Q000187:drug effects / Q000382:microbiology*; D014276:Trigeminal Nerve / Q000382:microbiology*; D014612:Vaccines / Q000494:pharmacology*; D014773:Virology / Q000379:methods
D014612:Vaccines