Localization of opiate and histamine H1-receptors in the primate sensory ganglia and spinal cord.
The autoradiographic localizations of opiate and histamine H1-receptors were studied quantitatively and compared following dorsal root section in the primate spinal cord. High densities of opiate and H1-receptors were found in the superficial layers of the dorsal horn. Dorsal root section produced a 40-50% loss of both receptors types throughout layers I and II with no loss in deeper layers of the dorsal horn. "Bursts' of opiate and H1-receptor labelling was observed over a population of small diameter cells (35-45 micron or micrometer) in the primate dorsal root ganglion. These cells represented approximately 8% of the total cells present. Serial consecutive sections demonstrated a population of cells bearing both opiate and histamine H1-receptors.
D000818:Animals; D001345:Autoradiography; D005048:Etorphine / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism*; D008253:Macaca mulatta; D011738:Pyrilamine / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*; D014316:Tritium
D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011957:Receptors, Opioid; D014316:Tritium; D005048:Etorphine; D011738:Pyrilamine