title: [Substances with antiviral activity. XIX. Amidinohydrazones of formylesters and formylthioesters with aromatic N-heterocyclic substrates].
abstract: Some formylthioester and formylester amidinohydrazones with aromatic N-heterocyclic moieties, were synthesized and screened in vitro against the MP mutant of herpes simplex virus type 1 [HSV-1 (MP)] and parainfluenza type 3 virus, HA-1/CR-8 strain. The amidinohydrazone of 1-phenyl-4-formyl-3-(ethylthio)carbonylpyrrole (I) was the most active compound.
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D006835:Hydrazones; D007211:Indoles; D011758:Pyrroles; D011804:Quinolines
vernacular_title: Richerche su sostanze ad attività antivirale. Nota XIX--Amidinoidrazoni di formilesteri e formiltioesteri consubstrati N-eterociclici aromatici.