[Drug induced pulmonary disease. Diffuse interstitial pneumonitis during chemoradiotherapy for small cell carcinoma of the lung. Two cases (author's transl)].
Two patients with small cell carcinoma of the lung treated by chemoradiotherapy developed, diffuse interstitial pneumonitis after 7 and 21 months of treatment while in complete remission of their malignant disease. One patient died after an acute respiratory distress syndrome, but the second improved after steroid therapy and discontinuation of cytotoxic therapy. Pulmonary toxicity appeared to be related to cyclophosphamide therapy, but radiation therapy could have potentiated cyclophosphamide toxicity as it has been shown in bleomycin lung disease.
D000368:Aged; D018288:Carcinoma, Small Cell / Q000188:drug therapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D011832:Radiation Injuries / Q000209:etiology; D011867:Radioisotope Teletherapy
D003037:Cobalt Radioisotopes; D003520:Cyclophosphamide
A propos des pneumopathies médicamenteuses. Deux observations de pneumopathie interstitielle diffuse au cours du traitement des cancers bronchiques à petites cellules. Rôle probable du cyclophosphamide.