Ascorbate suppresses the opiate-induced compensatory increase in cyclic AMP in neuroblastoma X glioma hybrid cells.
In NG108-15 hybrid cells ascorbate suppresses the delayed etorphine-induced compensatory increase in the levels of cyclic AMP. It has, however, no effect on the early response of the cells to etorphine, as manifested in a transient decrease in the levels of cyclic AMP.
D001205:Ascorbic Acid / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D005048:Etorphine / Q000494:pharmacology*; D005910:Glioma / Q000378:metabolism*; D006822:Hybrid Cells / Q000187:drug effects / Q000378:metabolism; D009019:Morphinans / Q000494:pharmacology*; D009447:Neuroblastoma / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism
D009019:Morphinans; D011957:Receptors, Opioid; D005048:Etorphine; D000242:Cyclic AMP; D001205:Ascorbic Acid