title: Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro.
abstract: The sensitivity of varicella zoster virus (VZV) strain Ellen to acyclovir in combination with other antiherpetic agents in vitro has been examined by the plaque-reduction and infectious center assay methods. (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), trifluorothymidine (TFT), or 5-iodo-2'-deoxyuridine (IdUrd) produced, in general, additive antiviral activity when examined by either assay method. Acyclovir in combination with phosphonoacetate (PAA) resulted in additive effects as measured by the plaque-reduction assay. The combination of acyclovir with 9-beta-D-arabinofuranosyladenine (ara-A) gave generally additive or occasionally synergistic antiviral activity when tested in MRC-5 or WI-38 cells respectively, regardless of assay method.
mesh_terms: D000212:Acyclovir; D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004357:Drug Synergism; D006147:Guanine / Q000031:analogs & derivatives / Q000494:pharmacology; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D007065:Idoxuridine / Q000494:pharmacology; D014271:Trifluridine / Q000494:pharmacology; D010948:Viral Plaque Assay
chemical_list: D000998:Antiviral Agents; C020235:brivudine; D006147:Guanine; D001973:Bromodeoxyuridine; D007065:Idoxuridine; D014271:Trifluridine; D000212:Acyclovir