Effect of protease inhibitors on the activation of Epstein-Barr virus repressed in cultured lymphoid cells.
The effects of five microbial and one synthetic protease inhibitors on the activation of Epstein-Barr virus expression in latency infected lymphoblastoid cells were studied. All protease inhibitors tested suppressed both viral antigen induction by 5-iododeoxyuridine treatment and cell growth in general. Among the inhibitors, however, antipain and pepstatin exerted a relatively strong and significant suppressive effect on antigen induction as compared to their inhibitory effect on cell growth.
D000956:Antigens, Viral; D001402:B-Lymphocytes; D002051:Burkitt Lymphoma; D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000254:growth & development*; D006801:Humans; D007065:Idoxuridine / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D014775:Virus Activation / Q000187:drug effects*
D000956:Antigens, Viral; D011480:Protease Inhibitors; D007065:Idoxuridine