Effects of diets rich and poor in fibres on the development of hereditary diabetes in mice.
Young mice with different genetic dispositions to obesity and hyperglycaemia were fed isocaloric diets rich (B-diet) or poor (O-diet) in fibre from rye. Normal C57BL/KsJ=+/+-mice developed equally well on the two diets with no differences in serum glucose or insulin. In non-inbred ob/ob-mice both diets were as effective as standard laboratory diet in supporting the fat accumulation and weight gain typical of these animals. No effect on serum insulin was observed, but at the age of 10 and 13 weeks the ob/ob-mice were more hyperglycaemic on the O-diet than on the B-diet. C57BL/KsJ-db/db-mice on the B-diet developed and maintained obesity until 20-25 weeks of age; they then began to lose weight and died at a median age of 36 weeks. KsJ-db/db-mice on the O-diet soon began to mobilize their fat reserves and died at a median age of 28 weeks; they also exhibited a more severe hyperglycaemia and less pronounced hyperinsulinaemia than KsJ-db/db-mice fed the B-diet. It is concluded that, at least in mice, the manifestations of a defined genetic disposition to severe diabetes mellitus can be modified by such simple an environmental factor as rye bran.
D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D004043:Dietary Fiber / Q000008:administration & dosage*; D002149:Energy Intake; D005260:Female; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese
D001786:Blood Glucose; D004043:Dietary Fiber; D007328:Insulin