[Influence of (+)-Catechin and Dithiocarb on the Pharmacokinetics of Phenprocoumon, Tolbutamide and Three Inhalation Anesthetics in rats].
Pretreatment with (+)-catechin ((+)-cyanidanol-3, Catergen) (200 mg/kg p.o.) did not alter the elimination of intravenously injected phenprocoumon (0.6 mg/kg) or tolbutamide (100 mg/kg) in rats, while dithiocarb (Sodium diethyl-dithiocarbamate) (200 mg/kg p.o.) prolonged only the elimination half-life of phenprocoumon to a small extent. The metabolism of halothane (100 ppm), enflurane (100 ppm) or methoxyflurane (300 ppm) was studied by measuring the disappearance of the compounds from the atmosphere of a closed exposure system. Pretreatment with (+)-catechin did not impair the metabolic removal of all three anesthetics; in the case of enflurane (+)-catechin caused a small, but significant shortening of the elimination half-life, for enflurane and methoxyflurane the uptake of the compounds into the rats seemed to be impaired under the influence of (+)-catechin. Dithiocarb strongly impaired the in vivo metabolism of halothane and methoxyflurane, whereas that of enflurane remained unaffected.
D015110:4-Hydroxycoumarins / Q000378:metabolism*; D000777:Anesthetics / Q000378:metabolism*; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D004347:Drug Interactions; D004737:Enflurane / Q000378:metabolism; D006221:Halothane / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008733:Methoxyflurane / Q000378:metabolism; D010644:Phenprocoumon / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013859:Thiocarbamates / Q000494:pharmacology*; D014044:Tolbutamide / Q000378:metabolism*
D015110:4-Hydroxycoumarins; D000777:Anesthetics; D001578:Benzopyrans; D013859:Thiocarbamates; D008733:Methoxyflurane; D002392:Catechin; D004737:Enflurane; D014044:Tolbutamide; D004050:Ditiocarb; D010644:Phenprocoumon; D006221:Halothane
Einfluss von (+)-Catechin und Dithiocarb auf die Pharmakokinetik von Phenprocoumon, Tolbutamid und drei Inhalationsanästhetika bei Ratten.