Presence of GABA receptors in rat oviduct.
A low concentration of high-affinity, saturable and specific [3H]GABA binding sites has been identified in a membrane fraction of rat oviduct. The specific binding of [3H]GABA was displaced by unlabelled GABA, muscimol and bicuculline. Furthermore in oviductal slices, GABA and a known GABA receptor agonist, i.e. muscimol, produced a significant elevation of cyclic AMP levels, which could be antagonized by GABA receptor blockers, i.e. picrotoxin and bicuculline. The present results indicate that GABA receptors may have a functional significance in rat oviduct.
D000818:Animals; D001640:Bicuculline / Q000378:metabolism; D001667:Binding, Competitive; D000242:Cyclic AMP / Q000378:metabolism; D005187:Fallopian Tubes / Q000294:innervation*; D005260:Female; D009118:Muscimol / Q000378:metabolism; D010852:Picrotoxin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D001640:Bicuculline; D000242:Cyclic AMP; D009118:Muscimol; D010852:Picrotoxin; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid