title: Factors influencing wound complications: a clinical and experimental study.
abstract: Burst abdomen, incisional herniation, sinus formation and post-operative wound infection continue to bedevil the surgeon. A prospective study of 1129 laparotomy wounds defined the extent of the problem; 1.7% incidence of dehiscence, 7.4% herniation and 6.7% sinus formation, all significantly associated with wound infection. Mass closure reduced the dehiscence rate from 3.8% to 0.76%. Infection reduced wound strength in a rat laparotomy model due to a decrease in fibroblast concentration and activity. A monofilament non-absorbable suture was shown experimentally to be the most suitable suture for closing infected abdominal wounds. Electron microscopy demonstrated bacteria in the interstices of infected multifilament sutures. A randomised clinical trial comparing polyglycolic acid and monofilament nylon in the closure of abdominal wounds confirmed the experimental findings; polyglycolic acid resulted in a significantly higher wound failure rate with no decrease in sinus formation. A mass closure technique using monofilament nylon is recommended for laparatomy closure and efforts should continue to reduce wound sepsis.
mesh_terms: D000818:Animals; D005347:Fibroblasts / Q000502:physiology; D006547:Hernia / Q000209:etiology; D006801:Humans; D007813:Laparotomy / Q000009:adverse effects*; D008855:Microscopy, Electron, Scanning; D009757:Nylons; D011100:Polyglycolic Acid; D051381:Rats; D013529:Surgical Wound Dehiscence / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology* / Q000473:pathology; D013537:Sutures; D014945:Wound Healing
chemical_list: D009757:Nylons; D011100:Polyglycolic Acid