Corneal epithelial healing rates after topical nucleotides.
Discrete 28mm2 epithelial lesions in paired rabbit corneas were treated four times daily with either vehicle alone or 10(-2)M or 10(-3)M Db cAMP in the presence or absence of either theophylline (10(-2)M) or epinephrine (5.5 x 10(-3)M). Cyclic GMP was also used either alone or with pilocarpine (1%). The lesion size was determined photographically at various intervals over 48 hours. No treatment regimen at the concentrations of cyclic nucleotides used had any influence on the rate of epithelial regrowth.
D000818:Animals; D003316:Corneal Diseases / Q000188:drug therapy*; D000242:Cyclic AMP / Q000627:therapeutic use; D006152:Cyclic GMP / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000627:therapeutic use; D009712:Nucleotides, Cyclic / Q000494:pharmacology / Q000627:therapeutic use*; D010862:Pilocarpine / Q000627:therapeutic use; D011817:Rabbits; D013806:Theophylline / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
D009712:Nucleotides, Cyclic; D010862:Pilocarpine; D013806:Theophylline; D000242:Cyclic AMP; D006152:Cyclic GMP; D004837:Epinephrine