Effect of various pharmacological agonists on the rat caecum-appendix preparation: a preliminary study.
A preliminary study with various pharmacological agents revealed the presence of contractile muscarinic and H1-histamine receptors as well as inhibitory alpha- and beta-adrenoceptors and purinoceptors in rat caecum-appendix. Histamine also produced indirect actions mediated through the release of catecholamines. 5-Hydroxytryptamine produced variable response, the contractile response was mediated through 5-HT receptors and the relaxant response through the release of catecholamines.
D000109:Acetylcholine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001065:Appendix / Q000032:analysis / Q000187:drug effects*; D005260:Female; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000032:analysis; D012701:Serotonin / Q000494:pharmacology
D011956:Receptors, Cell Surface; D012701:Serotonin; D006632:Histamine; D000255:Adenosine Triphosphate; D000109:Acetylcholine; D009638:Norepinephrine