Selective inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine.
The selectivity of inhibition of herpesvirus deoxyribonucleic acid synthesis by acycloguanosine, 2'-fluoro-5-iodo-aracytosine, and (E)-5-(2-bromovinyl)-2'-deoxyuridine was determined by isopycnic banding of (32)P-labeled deoxyribonucleic acid from herpesvirus-infected and uninfected cells.
D000212:Acyclovir; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002460:Cell Line; D002522:Chlorocebus aethiops; D003561:Cytarabine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D004279:DNA, Viral / Q000096:biosynthesis*; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007668:Kidney; D018139:Simplexvirus / Q000187:drug effects* / Q000378:metabolism
D000998:Antiviral Agents; D004279:DNA, Viral; D003561:Cytarabine; C020235:brivudine; C026023:fiacitabine; D006147:Guanine; D004247:DNA; D001973:Bromodeoxyuridine; D000212:Acyclovir