Stimulation of D-glucose transport. A novel effect of vitamin D on intestinal membrane transport.
Vitamin D stimulates absorption of D-glucose in chick jejunum and ileum by a specific action on the maximal velocity of Na+-gradient driven D-glucose transport across the brush-border membrane of intestinal cells. Induction of D-glucose transport by either vitamin D-3 or 1,25-dihydroxyvitamin D-3 in embryonic intestine can be blocked by inhibitors of RNA and protein synthesis.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002117:Calcitriol / Q000494:pharmacology; D002645:Chickens; D002762:Cholecalciferol / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000196:embryology; D007583:Jejunum / Q000378:metabolism*; D008871:Microvilli / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology
D002762:Cholecalciferol; D003609:Dactinomycin; D003513:Cycloheximide; D012964:Sodium; D002117:Calcitriol; D005947:Glucose