[Effect of nitroglycerin on the heart].
Nitroglycerin injection into the left coronary artery triggers an increase of ionized Ca concentration in coronary sinus blood. This coincides with a significant dilatation of the coronary artery and a decrease in left ventricular contractility. According to the results of the investigation it seems to be possible that nitroglycerin stimulates the Ca-ion efflux from the smooth muscle cells and the myocytes.
D002118:Calcium / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007473:Ion Channels; D009200:Myocardial Contraction / Q000187:drug effects; D005996:Nitroglycerin / Q000494:pharmacology*
D007473:Ion Channels; D005996:Nitroglycerin; D002118:Calcium
Zur Nitroglyzerin-Wirkung am Herzen.