Herpes simplex virus infection of human T-cell subpopulations.
The ability of herpes simplex virus type 1 to productively infect human T-cell subpopulations was examined. Unstimulated helper/inducer (T4+) and cytotoxic/suppressor (T8+) lymphocytes limited herpes simplex virus replication as effectively as unseparated peripheral blood T cells (T3+). Phytohemagglutinin stimulation before infection resulted in equivalently productive herpes simplex virus infections in the three cell fractions.
D000328:Adult; D002469:Cell Separation; D006801:Humans; D008213:Lymphocyte Activation; D018139:Simplexvirus / Q000502:physiology*; D013601:T-Lymphocytes / Q000382:microbiology*; D013602:T-Lymphocytes, Cytotoxic / Q000382:microbiology; D006377:T-Lymphocytes, Helper-Inducer / Q000382:microbiology; D050378:T-Lymphocytes, Regulatory / Q000382:microbiology; D014779:Virus Replication