Specific epidermal growth factor receptors on porcine thyroid cell membranes.
Specific saturable receptors for epidermal growth factor (EGF) of high affinity (Ka 1.7 X 10(9) M-1) have been demonstrated on porcine thyroid membranes. Optimal conditions for EGF binding have been determined. TSH and other peptide hormones do not inhibit the binding of 125I-EGF and EGF does not inhibit 125I-TSH binding to thyroid membranes. The results suggest that EGF may be involved in the regulation of thyroid follicular cell growth and function.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors; D007700:Kinetics; D008297:Male; D051379:Mice; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013552:Swine; D013696:Temperature; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism
D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D013972:Thyrotropin; D066246:ErbB Receptors