[Specific and metabolic effect of oxythiamine].
Increasing doses of oxythiamine were studied as exerting the effect on transketolase inactivation in rat tissues. A conclusion is made that in the process of synthesis de novo there is a transient form of the enzyme accessible for interaction with oxythiamine pyrophosphate. Injection of oxythiamine in the increasing doses are accompanied by a decrease in the glycogen amount, increase in the intracellular level most of the studied intermediates of glycolysis and pentose cycle as well as cAMP. The probable biochemical mechanism of the oxythiamine action is connected with the activation of processes dependent on cAMP.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D008297:Male; D010119:Oxythiamine / Q000494:pharmacology*; D010429:Pentoses / Q000378:metabolism; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000037:antagonists & inhibitors*
D010429:Pentoses; D013844:Thiazoles; D010119:Oxythiamine; D006003:Glycogen; D000242:Cyclic AMP; D014174:Transketolase
Spetsificheskie i metabolitnye éffekty oksitiamina.