Some theoretical questions of the peptide and steroid hormone regulation. Part III.: The RLVC hypothesis as a possible mode for the interaction of the peptide and steroid hormone regulation.
My previous models for peptide and steroid hormone actions, in accordance with their biological and molecular-informational requirements, suggested possible mechanisms for the subcellular interactions of the two regulatory systems. In my hypothesis the homogeneous or heterogeneous multiligand binding-proteins (receptors, characterized previously) have the ability to bind both steroids and (cyclic) nucleotide phosphates in a unique distribution and sequence. The specificity of such a Receptor-Ligand Variable Complex (RLVC), the pattern of the steroid and/or (cyclic) nucleotide phosphate ligands, is determined by the equilibrium between the actually acting steroids and peptides on the one hand and by the binding possibilities of the receptor on the other.
D000818:Animals; D006728:Hormones / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008954:Models, Biological; D010455:Peptides / Q000378:metabolism; D011453:Prostaglandins / Q000502:physiology; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D013256:Steroids / Q000378:metabolism
D006728:Hormones; D010455:Peptides; D011453:Prostaglandins; D011956:Receptors, Cell Surface; D013256:Steroids