[Modeling of persistent HeLa cell infections caused by different Japanese encephalitis virus clones].
The authors developed two models of persistent infections of a HeLa cell clone with mildly pathogenic clones of the Nakayama and Peking I strains of Japanese encephalitis virus. The distinguishing features of these models included the noncytocidal nature of the infectious process, predominance of the small-plaque phenotype, further decrease of the infectious properties of the persisting viruses. Altogether during the observation period 84 subpassages of each of the two systems were made without any visible signs of cell degeneration.
D002999:Clone Cells / Q000382:microbiology; D004664:Encephalitis Virus, Japanese / Q000472:pathogenicity*; D004672:Encephalitis, Japanese / Q000382:microbiology*; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D010948:Viral Plaque Assay; D014776:Virus Cultivation
Modelirovanie persistentnykh infektsii kletok HeLa, vyzvannykh raznymi klonami virusa iaponskogo éntsefalita.