The effect of dantrolene on tetanic potentiation of MEPP frequency in EGTA containing salines.
The effect of dantrolene on tetanic potentiation of MEPP frequency in salines containing 1 mM EGTA and no added Ca2+ has been examined. Dantrolene pre-treatment results in no significant change in the response of normalized MEPP frequency to tetanus at stimulation rates of both 25 and 100 Hz. This result is compared to the way in which dantrolene interacts with other agents that modify spontaneous release and it is suggested that intracellular Ca2+ movements during nerve tetanus may well be complex involving more than one Ca2+ store.
D000818:Animals; D003620:Dantrolene / Q000494:pharmacology*; D004533:Egtazic Acid / Q000494:pharmacology*; D004558:Electric Stimulation; D005026:Ethylene Glycols / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D009045:Motor Endplate / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D011896:Rana temporaria; D009435:Synaptic Transmission / Q000187:drug effects*
D005026:Ethylene Glycols; D007473:Ion Channels; D004533:Egtazic Acid; D003620:Dantrolene