Trimethoprim-polymyxin ophthalmic solution versus chloramphenicol ophthalmic solution in the treatment of bacterial conjunctivitis.
Forty patients with a diagnosis of presumptive bacterial conjunctivitis were treated with either trimethoprim-polymyxin or chloramphenicol ophthalmic solutions in a randomized, double-blind trial. No significant differences could be demonstrated between the results of 7-days' treatment with the two preparations and both solutions were found to be effective in improving the signs and symptoms of surface ocular bacterial infection. No adverse reactions were reported in either treatment group.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D003231:Conjunctivitis / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D004338:Drug Combinations; D006801:Humans; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use*; D011113:Polymyxins / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
D004338:Drug Combinations; D009883:Ophthalmic Solutions; D011113:Polymyxins; D002701:Chloramphenicol; D014295:Trimethoprim; D011112:Polymyxin B