Influence of age on the effects of chronic fluphenazine on receptor binding in rat brain.
The effects of age on alterations in brain dopaminergic (spiperone), beta-adrenergic (DHA), alpha-adrenergic (WB-4101), and cholinergic (QNB) binding induced by chronic administration of fluphenazine was studied in the rat. Compared to age-matched saline controls, older-age (25 month) fluphenazine rats showed: (a) a similar percent increase in specific spiperone binding (at 0.1 nM) but a slightly smaller increase in the Bmax of spiperone binding in the striatum than younger fluphenazine-treated rats; (b) a substantially greater increase in the Bmax of DHA binding and a slightly greater increase in Bmax of WB-4101 binding in the cerebral cortex than younger fluphenazine-treated rats. There was no significant interaction of age with the effect of chronic fluphenazine on QNB binding in rat striatum.
D000375:Aging; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005476:Fluphenazine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D005476:Fluphenazine