[Haemodynamic effect of naloxone during electrostimulation analgesia with special reference to the role of endorphin (author's transl)].
10 persons undergoing cardiac surgery in electro-stimulation analgesia (ESA) with controlled ventilation were given 5 microgram/kg bodyweight and 10 microgram/kg body-weight respectively of naloxone during the operation and the effects of the drug on the circulation were registered over a period of 10 minutes. The observations do not support the view that endorphin plays a part in ESA. Other possible modes of action are discussed.
D004305:Dose-Response Relationship, Drug; D004580:Electronarcosis; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009270:Naloxone / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects*
D011957:Receptors, Opioid; D009270:Naloxone
Hämodynamische Untersuchung unter Naloxone während der Elektrostimulationsanalgesie (ESA) als Beitrag zur Endorphintheorie.