title: Hypertension and neurofibromatosis. Case report.
abstract: A 14-year-old girl with neurofibromatosis presented with severe hypertension. She was subsequently found to have a cerebellar glioblastoma multiforme and vascular lesions producing coarctation of the abdominal aorta and 50% and 95% stenosis of the left and right renal arteries respectively. No evidence of pheochromocytoma was found. After removal of the cerebellar tumor, marked amelioration of the hypertension suggested that the tumor had a major role in the pronounced elevation of her blood pressure. Patients who have both neurofibromatosis and hypertension should be carefully evaluated for these several potential lesions.
mesh_terms: D000293:Adolescent; D001017:Aortic Coarctation / Q000150:complications; D002528:Cerebellar Neoplasms / Q000150:complications / Q000601:surgery; D002557:Cerebrospinal Fluid Shunts; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000601:surgery; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000628:therapy; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy; D006977:Hypertension, Renal / Q000209:etiology*; D006978:Hypertension, Renovascular / Q000209:etiology*; D007427:Intracranial Pressure; D008638:Mesenteric Arteries / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000150:complications*; D011433:Propranolol / Q000627:therapeutic use
chemical_list: D006852:Hydrochlorothiazide; D011433:Propranolol