title: Serum and tear immunoglobulin levels in acute adenovirus conjunctivitis.
abstract: Tear and serum IgG, IgA, and IgM levels were measured in 35 healthy subjects and 31 patients with acute conjunctivitis due to adenovirus 2, 7, and 8 infections. Serum IgG and IgM levels were found to be significantly low and there was no change in the serum IgA level. There was a significant rise in the tear IgG level. A progressive decline in the serum immunoglobulin level with the severity of the disease was observed. The changes in the immunoglobulin levels in serum and tears showed a tendency to reach normal levels with clinical improvement.
mesh_terms: D000208:Acute Disease; D000257:Adenoviridae Infections / Q000276:immunology*; D000258:Adenovirus Infections, Human / Q000276:immunology*; D000328:Adult; D003231:Conjunctivitis / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D013666:Tears / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins