[Catecholamine regulation of the liver and kidney ATPase activity in mice].
Noradrenaline (NA) and isopropyladrenaline in a dose of 11 microM/kg were shown to activate in vivo Na+, K+-ATPase and Mg2+-ATPase in the mouse renal microsomal fraction. NA (10(-6) M) increased the activity of Na+, K+-ATPase in vitro and did not affect the activity of Mg2+-ATPase in the hepatic and renal microsomal fractions. NA did not significantly affect in vivo the mitochondrial ATPases activity in the presence of various stimulators (Mg, dinitrophenol, bicarbonate) and inhibitors (oligomycin, bicyclohexyl carbodiimide) in the mouse liver and kidneys. cAMP (10(-6) M) activated Na+, K+-ATPase in vitro reduced the activity of Mg2+-ATPase in the microsomal fraction, and did not change the activity of the mitochondrial ATPases in the mouse liver and kidneys. The following scheme of the mechanism of catecholamine (CA) effect on Na+, K+-ATPase is suggested: CA leads to beta-adrenoreceptors leads to adenylate cyclase leads to cAMP leads to protein kinase leads to Na+, K+-ATPase. The mechanism of Mg2+-ATPase regulation is discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002395:Catecholamines; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase; D007545:Isoproterenol; D004837:Epinephrine
Issledovanie katekholaminovoĭ reguliatsii ATF-aznoĭ aktivnosti pecheni i pochek mysheĭ.