title: Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.
abstract: The composition, environmental fate, and effects of the polybrominated biphenyls (Firemaster BP-6 or FF-1) involved in the accidental contamination of cattle feed in Michigan in 1973 are reviewed. Toxic effects referred to in this report are limited to those occurring in domestic and laboratory animals and include general toxicity, neurobehavioral toxicity, immunotoxicity, reproductive toxicity, mutagenicity and carcinogenicity. The absorption, distribution, biotransformation and elimination of these polybrominated biphenyls are discussed along with the interactions with other chemicals and drugs.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000633:toxicity*; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D004787:Environmental Pollution / Q000032:analysis; D004790:Enzyme Induction / Q000187:drug effects; D007109:Immunity / Q000187:drug effects; D007408:Intestinal Absorption; D009153:Mutagens; D011075:Polybrominated Biphenyls / Q000032:analysis / Q000633:toxicity*; D012098:Reproduction / Q000187:drug effects; D012756:Sheep; D013552:Swine; D014018:Tissue Distribution
chemical_list: D001713:Biphenyl Compounds; D002273:Carcinogens; D009153:Mutagens; D011075:Polybrominated Biphenyls