New findings concerning the pathogenesis of acute carbon monoxide (CO) poisoning.
The pathomechanism of carbon monoxide (CO) poisoning was studied by means of cardiopathological and neuropathological investigations in experimental CO intoxication. It has been shown that besides CO-hemoglobin association, the binding of CO to cytochromes is a significant factor. The latter is thought to be responsible for the cytotoxic phenomena. Combined ultrastructural and cytochemical studies have enabled differentiation between toxic, hypoxic, and mixed alternations.
D000208:Acute Disease; D000262:Adenylyl Cyclases / Q000032:analysis; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000648:ultrastructure; D002249:Carbon Monoxide Poisoning / Q000473:pathology*; D004195:Disease Models, Animal; D003576:Electron Transport Complex IV / Q000032:analysis; D006651:Histocytochemistry; D008854:Microscopy, Electron; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure; D009940:Organoids / Q000648:ultrastructure; D051381:Rats; D013385:Succinate Dehydrogenase / Q000032:analysis
D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D000262:Adenylyl Cyclases