Adriamycin inhibits the formation of non-bilayer lipid structures in cardiolipin-containing model membranes.
The effect of adriamycin on cardiolipin-containing model membrane systems have been studied by 31P-NMR, freeze-fracture electron microscopy and binding experiments. Adriamycin effectively inhibits the formation of non-bilayer lipid structures induced by Ca2+ and cytochrome c in cardiolipin-containing liposomes. This drug also strongly inhibits the uptake of Ca2+ by cardiolipin into an organic phase. These results are discussed in relation to the cardiotoxic effect of adriamycin and the possible importance of non-bilayer lipid structures for the functioning of the mitochondrion.
D002118:Calcium; D002308:Cardiolipins; D003574:Cytochrome c Group; D004317:Doxorubicin; D005614:Freeze Fracturing; D007700:Kinetics; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D008854:Microscopy, Electron; D008954:Models, Biological; D008968:Molecular Conformation; D010713:Phosphatidylcholines
D002308:Cardiolipins; D003574:Cytochrome c Group; D008081:Liposomes; D010713:Phosphatidylcholines; D004317:Doxorubicin; D002118:Calcium