Striatal 3-methoxytyramine as an index of dopamine release effects of electrical stimulation.
Electrical stimulation of the substantia nigra elicited frequency-dependent increases in striatal 3-methoxytyramine (3-MT). Subsequently, successive increases in dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. Inhibition of nigrostriatal cell firing with HA-966 resulted in decreased striatal 3-MT, but in this case elevated DOPAC and HVA were also observed. These data indicate that 3-MT is a reliable index of dopamine (DA) release but that concurrent measurements of DOPAC, HVA and DA provide the most reliable interpretation of drug effects on dopaminergic function.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000031:analogs & derivatives* / Q000378:metabolism*; D004558:Electric Stimulation; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D011760:Pyrrolidinones / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000502:physiology; D009435:Synaptic Transmission
D011760:Pyrrolidinones; D015102:3,4-Dihydroxyphenylacetic Acid; C001369:1-hydroxy-3-amino-2-pyrrolidone; C001746:3-methoxytyramine; D004298:Dopamine; D006719:Homovanillic Acid