[Molecular mechanism of combined effect of amphotericin B and cyclophosphamide on a virus-induced neoplastic process].
Study of an experimental neoplastic process induced by virus type strains of Rous's sarcoma has shown that amphotericin B potentiates antineoplastic action of cyclophosphamide. Administration of cytostatin does not affect the fractional composition of chromatin proteins. Administration of polyene changes this indicator, the changes being greater after combined use of both drugs. The character of a considerable part of the abnormalities in the fractional composition of chromatin proteins indicates that chromatin had been exposed to proteolytic enzymes.
D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004347:Drug Interactions; D004591:Electrophoresis, Polyacrylamide Gel; D009698:Nucleoproteins / Q000378:metabolism*; D001357:Sarcoma, Avian / Q000188:drug therapy / Q000378:metabolism*
D009698:Nucleoproteins; D000666:Amphotericin B; D003520:Cyclophosphamide
Molekuliarnyĭ mekhanizm sochetannogo deĭstviia amfoteritsina B i tsiklofosfana na virusindutsirovannyĭ neoplasticheskiĭ protsess.