Stimulation of Na+ -dependent amino acid uptake by activation of the Ca2+ -dependent K+ channel in the Ehrlich ascites tumor cell.
The activation of Ca2+ -dependent K+ channel by propranolol or by ascorbate-phenazine methosulphate stimulates Na+ -dependent transport of alpha-aminoisobutyric acid. This stimulation arises from a membrane hyperpolarization due to the specific increase of membrane K+ conductance. The same treatment does not modify the Na+ -independent uptake of the norbornane amino acid.
D000596:Amino Acids / Q000378:metabolism*; D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008773:Methylphenazonium Methosulfate / Q000494:pharmacology; D051379:Mice; D011188:Potassium / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology*
D000596:Amino Acids; D000621:Aminoisobutyric Acids; D007473:Ion Channels; D008773:Methylphenazonium Methosulfate; D012964:Sodium; D011433:Propranolol; D001205:Ascorbic Acid; D011188:Potassium; D002118:Calcium