Effect of acyclovir, bromovinyldeoxyuridine, vidarabine, and L-lysine on latent ganglionic herpes simplex virus in vitro.
Vidarabine and L-lysine did not prevent the in vitro reactivation of latent herpes simplex virus or block the further multiplication of reactivated latent virus. Acyclovir and bromovinyldeoxyuridine both blocked the reaction and the multiplication of reactivated latent virus, and transiently suppressed but did not eliminate latent virus from the sensory ganglia.
D000212:Acyclovir; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000494:pharmacology; D046508:Culture Techniques; D006147:Guanine / Q000031:analogs & derivatives / Q000494:pharmacology; D008239:Lysine / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D013237:Stereoisomerism; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014276:Trigeminal Nerve / Q000382:microbiology*; D014740:Vidarabine / Q000494:pharmacology
D000998:Antiviral Agents; C020235:brivudine; D006147:Guanine; D014740:Vidarabine; D001973:Bromodeoxyuridine; D008239:Lysine; D000212:Acyclovir