Correlation between mixed lymphocyte cultures and anti-Epstein Barr virus (EBV) antibodies in Hodgkin's disease and non Hodgkin lymphoma patients.
Cellular and humoral immunity was examined in Hodgkin's disease and non Hodgkin lymphoma (33) patients and compared with a normal group. Mixed lymphocyte cultures (MLC) were used as parameter for cell mediated immunity and anti-Epstein Barr virus (EBV) antibodies for specific humoral immunity. High stimulation indices coincided with low anti-VCA and anti-EBNA titers in the control group (r = -0.343). This negative correlation was not found in non Hodgkin lymphomas and was substantially lower (r = -0.142) in Hodgkin's disease. The alterations in immunoregulatory mechanisms in these patients are discussed.
D000914:Antibodies, Viral / Q000032:analysis*; D000917:Antibody Formation; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007959:Lymphocyte Culture Test, Mixed; D008223:Lymphoma / Q000276:immunology*
D000914:Antibodies, Viral