[Hepatitis B virus and hepatoma: evidence for a cytoplasmic tumor antigen in transformed hepatocytes].
A tumoural antigen (HBV/T Ag) has been found in the cytoplasm of the human hepatoma cell line PLC/PRF/5 by indirect immunofluorescence and immunoperoxidase assays using anti-sera from Senegalese patients with primary hepatocellular carcinoma. The same antigen was detected in PHC tissues. According to the data obtained with serum and tissue controls the HBV/T Ag-anti-HBV/T system seems associated with transformation of hepatocytes by hepatitis B virus.
D000956:Antigens, Viral / Q000032:analysis*; D000957:Antigens, Viral, Tumor; D006528:Carcinoma, Hepatocellular / Q000382:microbiology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D005455:Fluorescent Antibody Technique; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000382:microbiology*
D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor
Virus de l'hépatite B et cancer primitif du foie: mise en évidence d'un antigène tumoral cytoplasmique dans l'hépatocyte transformé.