Morphogenetic effect of cAMP during the metamorphosis of the frog larva.
In an in vitro system, the tail absorption of the frog larva was significantly stimulated by cAMP more intensely than by T3. Theophylline, an inhibitor of cPDE, had no effect and failed to enhance, even decreased the effect of T3. It may be supposed that T3 does not act through a cAMP mechanism, but the tail absorption can be influenced by cAMP in a direct way.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000502:physiology*; D007814:Larva / Q000187:drug effects / Q000502:physiology; D008675:Metamorphosis, Biological / Q000187:drug effects*; D011898:Ranidae; D013806:Theophylline / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D003994:Bucladesine; D013806:Theophylline; D000242:Cyclic AMP