[Fenibut binding with bicuculline-insensitive GABA receptors in the rat brain].
(+/-) Fenibut beta-phenyl-GABA) was not able to displace 3H-GABA in Na+ independent GABA binding (IC50 greater than 250 microM). Nevertheless, (+/-) fenibut and (+/-) baclofen effectively displaced 3H-GABA in Ca2+ dependent GABA binding in the presence of 50 microM (+) bicuculline. (+/-) Fenibut was less potent in this respect. It is suggested that fenibut may act via bicuculline-insensitive GABA receptors.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002118:Calcium; D003342:Corpus Striatum / Q000502:physiology*; D004351:Drug Resistance; D066298:In Vitro Techniques; D007536:Isomerism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000502:physiology; D012964:Sodium; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*
D011956:Receptors, Cell Surface; D005680:gamma-Aminobutyric Acid; D012964:Sodium; D002118:Calcium; C008842:4-amino-3-phenylbutyric acid; D001640:Bicuculline
O sviazyvanii fenibuta s bikukullinnechuvstvitel'nymi retseptorami GAMK v mozge krys.