Insulin acutely increases phospholipids in the phosphatidate-inositide cycle in rat adipose tissue.
Administration of insulin in vivo provoked rapid (near maximal in 30 min) increases (65-90%) in the concentrations of phosphatidic acid, phosphatidylinositol, and polyphosphoinositides in rat adipose tissue. Insulin also increased phosphatidylinositol levels in adipocytes incubated in vitro. Dose-response relationships suggested that these effects of insulin were physiologically relevant. The enrichment of membranes with acidic phospholipids in the phosphatidate-inositide cycle may play a role in the action of insulin in adipocytes.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D010712:Phosphatidic Acids / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D011108:Polymers / Q000378:metabolism; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D010712:Phosphatidic Acids; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D010743:Phospholipids; D011108:Polymers