[The study for the standard of the remission of the patients with trophoblastic disease (author's transl)].
The recurrence of the patients who had obtained remissions once was studied and the standard of remission was reassessed. The comparison of the titers of hCG ranged the LH levels was studied by means of some methods of measurement. 1) During 7 years, from 1973-1979, 141 patients with trophoblastic disease in Chiba University Hospital were treated. The remission rate was 92.2% (130/141), the recurrence rate was 6.2% (8/130). In the high risk group, the recurrence rate was 23.1% (6/26), in the low risk, it was 1.9% (2/104). Four of 8 with recurrence were died, 4 (2 high risk and 2 low risk) obtained remissions again. 2) The mean HCG titers of patients with recurrence were 29.5 +/- 23.5 IU/L (HAR), 13.7 +/- 6.4 mIU/ml (HCG-RIA), 1.5 +/- 0.7 ng/ml (HCG-beta RIA) and that of patients with remission were 13.8 +/- 13.0 IU/L, 11.3 +/- 4.1 mIU/ml, 1.0 +/- 0.6 ng/ml, respectively. 3) The 2 patients whose HCG titers indicated all negative followed the recurrences. The HCG beta titers of the patients who were extirpated their bilateral ovaries indicated rather high in spite of getting their remissions. 4) The essential standard of remission was the equanimity of the HCG titers around the negative levels without disturbance by LH or other substances for a while. But it is not enough for a remission.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D012008:Recurrence; D014328:Trophoblastic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D014594:Uterine Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone