Age-related decrease of in vitro isoproterenol-induced cyclic AMP accumulation in rat aorta.
Isoproterenol-induced accumulation of cyclic AMP was investigated in aorta rings from 7 to 18 weeks old rats. The effect of isoproterenol on cyclic AMP reached a maximum in 1 min. The concentration-effect curves showed a significant decrease of the maximal accumulation of cyclic AMP as a function of age, without any variation in the effective concentration range. These results parallel the previously reported decrease of beta-adrenergic relaxation of rat aorta with age.
D000375:Aging; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D001158:Arteries / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004247:DNA; D000242:Cyclic AMP; D007545:Isoproterenol