Desensitization-like changes in GABA receptor binding of rat fascia dentata after entorhinal lesion.
Destruction of the hippocampal perforant path fibers reduced the binding of [3H]GABA to membranes prepared from the rat fascia dentata. This result could be detected 1--4 months after surgery, but not in 10 days or less. Such a delayed response appears most compatible with a transsynaptic effect on GABA receptors. Values of low affinity KD and Bmax decreased by about 65%, but no changes were detected in high affinity binding, Hill slope or pharmacological specificity. These findings are consistent with a desensitization of postsynaptic low affinity GABA receptors, possible caused by excessive release of GABA.
D000818:Animals; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006624:Hippocampus / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009666:Nose / Q000294:innervation; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000378:metabolism*; D012683:Sensory Deprivation / Q000502:physiology; D012903:Smell / Q000502:physiology; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011955:Receptors, Drug; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase