Differential tumor immunogenicity of DBA/2 mouse lymphoma L1210 and its sublines. III. Control of host resistance to drug-resistant L1210 sublines by H-2-linked and non-H-2-linked genes.
The effects of the host's genetic composition on the host's resistance to the DBA/2 L1210 lymphoma and three drug-resistant L1210 sublines (which show an increased expression of tumor-associated antigens) were investigated. Histocompatible F1 mice between DBA/2 and other mouse strains were given injections ip of graded numbers of these tumor cells, and a marked difference in the resistance of the host to tumor growth was demonstrated. The resistant hybrid mice showed markedly higher resistance to the L1210 sublines than to the L1210 parent lymphoma cells. Experiments with F1 mice between DBA/2 (H-2d) and certain congeneic intra-H-2 recombinant strains showed that the H-2b/d heterozygosity at the H-2K+l-A regions and additional non-H-2 genetic factor(s) confer the resistance to the F1 mice. The resistance was abolished by treating host animals with injections of silica, an antimacrophage agent, or rabbit anti-mouse thymocyte serum. These results suggest that the resistance is immunologic and that the genetically controlled host resistance may be directed to surface changes related to the increased expression of tumor-associated antigens.
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics; D003433:Crosses, Genetic; D004351:Drug Resistance; D006183:H-2 Antigens / Q000235:genetics*; D006238:Haploidy; D006579:Heterozygote; D007126:Immunoglobulin Allotypes / Q000235:genetics; D007939:Leukemia L1210 / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA / Q000276:immunology*; D008815:Mice, Inbred Strains / Q000276:immunology*; D012822:Silicon Dioxide / Q000627:therapeutic use; D013045:Species Specificity; D013950:Thymus Gland / Q000276:immunology
D000951:Antigens, Neoplasm; D006183:H-2 Antigens; D007126:Immunoglobulin Allotypes; D012822:Silicon Dioxide