In vivo enhancement of mitogen-induced lymphocyte DNA synthesis by sodium diethyl-dithiocarbamate (DTC).
Sodium diethyl dithiocarbamate (DTC), a low molecular weight sulphur compound, has been previously shown to be endowed of immunomodulatory properties. To get a better understanding of the mechanisms whereby DTC regulates the immune response, mitogen-induced lymphoproliferation was studied in spleen from guinea pigs treated with a single i.v. injection of DTC. The results clearly show that DTC enhances, after a lag period, DNA synthesis in T and B lymphocytes. DTC which appears not to act at the level of immuno-competent cells seems to modulate the immune responses through indirect pathways.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D004050:Ditiocarb / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D008214:Lymphocytes / Q000378:metabolism*; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D013268:Stimulation, Chemical; D013859:Thiocarbamates / Q000494:pharmacology*
D008934:Mitogens; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D013859:Thiocarbamates; D003208:Concanavalin A; D004247:DNA; D004050:Ditiocarb