Functional changes of macrophages from polyoma tumor-bearing mice.
CBA mice were inoculated with different doses of polyoma tumor cells. The PHA response of spleen cells from tumor-bearers was decreased but the spontaneous incorporation of 3H-leucine was increased. PHA-induced cytotoxicity of spleen cells was increased only in tumor-bearers. The expression of Fc receptors showed a slight increase on adherent cells from spleen and peripheral blood mononuclear cells under suboptimal conditions for EA rosette formation (small amount of antibody for coating the erythrocytes). The non-specific esterase activity was assayed in an extract of peritoneal macrophages and the elevated activity with isoenzymes was seen in a group of tumor-bearers. The results suggest a functional alteration of macrophages in polyoma tumor-bearing mice.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D004950:Esterases / Q000378:metabolism; D005260:Female; D008213:Lymphocyte Activation; D008264:Macrophages / Q000201:enzymology / Q000276:immunology / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011120:Polyomavirus; D011961:Receptors, Fc; D014412:Tumor Virus Infections / Q000276:immunology*
D011961:Receptors, Fc; D004950:Esterases