title: [Cytogenetic aspects of diffuse scleroderma. Structural anomalies and sister chromatid exchanges].
abstract: Structural chromosome anomalies (1 477 cells examined) and sister chromatid exchanges after two replication cycles with BrdU (771 cells studied) were evaluated in 12 patients with diffuse scleroderma and having received no recent or important irradiation. The increase of structural anomalies, chromatidic as well as chromosomal, is always low, inconstant and cannot be considered as having a diagnostic value. Increase of sister chromatid exchanges could be a more sensitive method of investigation. In particular, it is not influenced by low doses of diagnostic X-rays.
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000528:radiation effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012595:Scleroderma, Systemic / Q000000981:diagnostic imaging / Q000235:genetics* / Q000532:radiotherapy; D012854:Sister Chromatid Exchange / Q000528:radiation effects
vernacular_title: Aspects cytogénétiques de la sclérodermie généralisée. Anomalies structurales et échanges de chromatides-soeurs.