Effect of ethanol-containing liquid diet upon gonadotropin receptor depletion in rat testis.
By using pair-feeding technique, the number of gonadotropin binding sites per unit mass of testicular homogenate was measured 15, 30, 45 and 60 days after ethanol administration to 60-day-old male rats. The ingestion of ethanol (5%, v/v) as a part of a nutritionally adequate liquid diet resulted in 30, 35 and 40% reduction in gonadotropin receptors by 15, 30 and 45 days, respectively. The body weights in the alcohol-fed rats were comparable to pair-fed controls. These findings suggest that the presence of ethanol in the liquid diet depresses the level of gonadotropin receptors in the rat testis.
D000818:Animals; D001835:Body Weight; D002149:Energy Intake; D000431:Ethanol / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011974:Receptors, LH; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D011956:Receptors, Cell Surface; D011974:Receptors, LH; D000431:Ethanol; D007986:Luteinizing Hormone