Herpesvirus-specific RNA and protein in carcinoma of the uterine cervix.
Cloned probes of herpes simplex virus type 2 DNA were used in cytological hybridization experiments to detect herpesvirus RNA transcripts in the neoplastic cells of tumors of the uterine cervix. Virus-specific RNA was shown to represent transcription of limited regions of the genome, of which one is known to code for a DNA-binding protein that can be found by immunoperoxidase staining in the neoplastic cells of these tumors and has also been detected in cells transformed in vitro by this virus.
D000956:Antigens, Viral / Q000032:analysis; D002277:Carcinoma / Q000382:microbiology*; D002472:Cell Transformation, Viral; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000032:analysis*; D018139:Simplexvirus / Q000032:analysis* / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000382:microbiology*; D014764:Viral Proteins / Q000032:analysis*
D000956:Antigens, Viral; D004273:DNA, Neoplasm; D012367:RNA, Viral; D014764:Viral Proteins