[Implantation of Rous sarcoma virus transformed cells in the hamster: effect of various parameters].
The effect of inoculation of allogeneic hamster cells transformed by Rous sarcoma virus on tumour growth, in the hamster is described. Inoculation of low doses (10(2)-10(4)) of live cells was followed by the apparition and the growth of sub-cutaneous sarcomas. Repeated injections of irradiated or glutaraldehyde-treated cells which induce immune reactions led only to partial protection since they did not totally prevent tumour growth, after challenge with strong doses (5 X 10(4)) of live transformed cells. Inoculation route did not influence tumour growth, whatever the nature of injected cells. The interest of using irradiated or glutaraldehyde-treated transformed cells in tumour immunity should be emphasised.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000276:immunology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D002999:Clone Cells; D006224:Cricetinae; D005976:Glutaral / Q000494:pharmacology; D008647:Mesocricetus; D012513:Sarcoma, Experimental / Q000276:immunology / Q000382:microbiology*
D005976:Glutaral
Implantation de cellules transformées par le virus du sarcome de Rous chez le hamster: influence de quelques paramètres.