[Causative investigations of heparin-induced rise on thyroid hormone serum levels (author's transl)].
Intravascular application of heparin causes a significant rise of free and total thyroid hormone concentrations in serum together with a concomitant drop of the TSH-levels. A causal relationship between these two findings has been firmly established by a number of investigators. The decline of TSH concentrations in serum after heparin injection might just be a physiological reaction of the pituitary gland to the heparin-triggered rise of serum thyroid hormone levels. The present investigations demonstrate a diminution of affinity of thyroid hormone receptors of liver cells. This result confirms the hypothesis that the rise of total thyroid hormone in blood is mainly due to a depletion of liver stores of thyroid hormones. In concordance with clinical findings the binding affinity of cellular pituitary thyroid hormone receptors was found to increase.
D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood
D011956:Receptors, Cell Surface; D013963:Thyroid Hormones; D013972:Thyrotropin; D006493:Heparin
Untersuchungen zur Ermittlung der Ursachen der heparin-induzierten Konzentrationsanhebung der Schilddrüsenhormone im Serum.