Microcephaly, mental retardation and chromosomal aberrations in a girl following radiation therapy during late fetal life.
A human foetus was heavily irradiated in the thirtieth to the thirty-third week due to carcinoma of the uterine cervix of the mother. Irradiation after 20 weeks of pregnancy is thought not to produce severe abnormalities. However, the child showed microcephaly, mental retardation, stunted growth, microphthalmus, retinal degeneration, cataract and defective dentition. Cytogenetically the frequencies of both chromatid and chromosome breaks were increased.
D000015:Abnormalities, Multiple / Q000209:etiology; D000016:Abnormalities, Radiation-Induced / Q000209:etiology*; D000328:Adult; D002386:Cataract / Q000209:etiology; D002648:Child; D002869:Chromosome Aberrations; D003817:Dentition / Q000528:radiation effects; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology*; D008831:Microcephaly / Q000209:etiology*; D008850:Microphthalmos / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000532:radiotherapy; D011297:Prenatal Exposure Delayed Effects; D011882:Radiotherapy, High-Energy / Q000009:adverse effects*; D012162:Retinal Degeneration / Q000209:etiology; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy