Development and regulation of the prostaglandin F2 alpha receptor in the rat ovary.
Ovaries of adult rats specifically bind PGF2 alpha while those of immature animals do not. Induction of luteinization by hCG in juvenile animals, however, results in specific binding of PGF2 alpha. It is suggested that luteal cells are the only cell type of the ovary, which is endowed with specific receptors for PGF2 alpha. The number of PGF2 alpha binding sites varies during the ovarian cycle. Most free receptors are detectable in early pro-oestrus, least in the oestrus stage. The oscillation of receptors disappears after inhibition of prostaglandin synthesis by indomethacin. Therefore the apparent cyclic variation of prostaglandin receptors must be ascribed to occupancy of the receptors by varying amounts of endogenous prostaglandin F2 alpha.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004971:Estrus; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D010053:Ovary / Q000378:metabolism*; D011247:Pregnancy; D011460:Prostaglandins F / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D011982:Receptors, Prostaglandin / Q000187:drug effects
D006063:Chorionic Gonadotropin; D011460:Prostaglandins F; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin; D007213:Indomethacin