Immunocytochemical localization of angiotensin immunoreactivity in gonadotropes and lactotropes of the rat anterior pituitary gland.
Utilizing an immunocytochemical technique wherein two different antigens can be visualized on the same tissue section, angiotensin-like immunoreactivity was found in rat adenohypophyseal cells that showed staining with antisera to hLH, hFSH or human prolactin. Angiotensin-like immunoreactivity was not found in cells that showed staining with antisera to hTSH, C-terminal ACTH or hGH. The nature and possible physiologic significance of the angiotensin-like immunoreactivity is discussed.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism; D007124:Immunoenzyme Techniques; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D009115:Muridae; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D011945:Receptors, Angiotensin / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism
D006065:Gonadotropins, Pituitary; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone