[Elaboration of a method of stabilizing the protective fraction of pertussis microbes].
A method for stabilizing adsorbed preparations of the protective fraction of B. pertussis has been developed; according to this method, a colloid suspension of protective protein in phosphate buffer is obtained, the protein is then adsorbed on aluminium hydroxide gel and lyophilized with 10% of sucrose. If stored at 4 degrees C, these dried preparations have been found to retain their immunogenicity for 1 year.
D000327:Adsorption; D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000276:immunology*; D004355:Drug Stability; D004356:Drug Storage; D007114:Immunization; D008722:Methods; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors
D001426:Bacterial Proteins
Razrabotka metoda stabilizatsii protektivnoĭ fraktsii kokliushnykh mikrobov.