[Electron microscopic study of the in vitro effect of dipyridamol on the pseudorabies virus].
Dipyridamole at a concentration of 50 microM/ml displays no activity on adsorption and penetration of pseudorabies virus in chicken embryonal cells. Furthermore, first stages of virus replication take place within the nucleus, whereas incomplete virus cores defective in DNA content are found within the nucleoplasm at times when the regular viral replication has been finished in controls. Defective pseudorabies virus particles lacking in DNA-content of the core, can be observed at the end of normal replication time. Consequently, the antiviral activity of dipyridamole may be due to blocking of the synthesis or of the incorporation of infectious viral DNA into the virus core.
D000818:Animals; D002467:Cell Nucleus / Q000382:microbiology; D002478:Cells, Cultured; D002642:Chick Embryo; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral / Q000378:metabolism; D004176:Dipyridamole / Q000494:pharmacology*; D011558:Herpesvirus 1, Suid / Q000187:drug effects* / Q000648:ultrastructure; D014617:Vacuoles / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects
D004279:DNA, Viral; D004176:Dipyridamole
Elektronenoptische Untersuchungen zur in vitro-Wirkung von Dipyridamol auf das Pseudorabiesvirus.