Effect of lithium on normal and chronic granulocytic leukemia colony forming cells (CFU-GM).
The effect of lithium on normal and chronic granulocytic leukemia (CGL) granulo-monocytic precursors (CFU-GM) has been studied. Lithium slightly increases normal CFU-GM growth whereas it is without effect or moderately inhibitory for CGL CFU-GM. It is suggested that it is unlikely that lithium therapy enhances the proliferation of a silent leukemic clone.
D001853:Bone Marrow / Q000503:physiopathology; D002712:Chlorides / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000503:physiopathology*; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride