X-ray microanalysis of the Michaelis-Gutmann bodies of malakoplakia.
The Michaelis-Gutmann (MG) inclusion bodies of three cases of malakoplakia (prostate, testis, colon) were studied by X-ray microanalysis to determine their elemental composition. Calcium and phosphorus were consistently found. Iron was detected in a few bodies. No other elements were detected. The electrondense laminations were of similar composition to the core material. Small aggregates of electron-dense material containing calcium and phosphorus were also occasionally seen in phagolysosomes. These observations are consistent with view that MG bodies arise by a process of phagolysosomal coalescence and mineralisation.
D000368:Aged; D002118:Calcium / Q000032:analysis; D003106:Colon / Q000648:ultrastructure; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008287:Malacoplakia / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D010758:Phosphorus / Q000032:analysis; D011467:Prostate / Q000648:ultrastructure
D010758:Phosphorus; D002118:Calcium