[Endocrine reaction pattern in the course of a one-phase tramadol-N2O combination anesthesia].
The effects of Tramadol-N2O-anaesthesia on the per- and postoperative change in blood concentrations of cortisol, prolactin, thyroxine, triiodothyronine, cyclic AMP, glucagon, antidiuretic hormone, PTH-peptide (44-68), glucose, lactate, pyruvate and free fatty acids (FFA) were investigated in connection with elective orthopaedic surgery. Anaesthesia in man with Tramadol and nitrous oxide were found to be associated with a significant elevation of plasma cortisol and plasma prolactin in man. However, cortisol secretion during anaesthesia is associated with an inhibition in T4-T3 conversion. No significant alterations in plasma glucagon concentrations were observed. Generally, surgical trauma induced a significant increase in plasma cyclic AMP with intraoperative levels between 26.4 and 34.3 pmol/ml. At the end of surgery a significant fall in plasma PTH-peptide (44-68) occurred. There was also a significant change in plasma ADH levels following induction of anaesthesia. During surgery we found plasma ADH levels up to 56 pg/ml. In addition stress and surgical trauma increased blood glucose and FFA while plasma pyruvate and plasma lactate nearly remained unchanged. The data would suggest that the non-specific stress response attributed to anaesthesia may in fact be reflecting a response to relatively light anaesthesia.
D000328:Adult; D000768:Anesthesia, General; D001786:Blood Glucose / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood; D003511:Cyclohexanols; D004734:Energy Metabolism / Q000187:drug effects; D005934:Glucagon / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008023:Ligaments, Articular / Q000293:injuries / Q000601:surgery; D008297:Male; D009609:Nitrous Oxide; D011388:Prolactin / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D014147:Tramadol
D001786:Blood Glucose; D003511:Cyclohexanols; D006728:Hormones; D013963:Thyroid Hormones; D014147:Tramadol; D011388:Prolactin; D005934:Glucagon; D000242:Cyclic AMP; D009609:Nitrous Oxide
Endokrine Reaktionsmuster im Verlauf der einphasigen Tramadol-N2O-Kombinationsnarkose.