title: [Improved prognosis in Wilms' tumor due to adjuvant combination drug therapy].
abstract: 78 children with Wilms' tumor stage I--IV diagnosed since 1960 are presented. There were two groups of patients: one group consisting of 35 patients which received adjuvant chemotherapy for 1 year, the other group consisting of 43 patients which received no chemotherapy. Surgical excision and irradiation was identical in both groups. The prognosis was greatly improved by adjuvant chemotherapy: 4-year survival rates increased from 25 to 69%. Late side effects from radiation and chemotherapy were noted: 15/78 patients suffered from scoliosis and all patients treated by chemotherapy had a decreased lymphotoxin activity over years. The following factors appear to be related to prognosis: the extent of disease in patients determined by better techniques, histopathology of the tumor, and the nature of treatment.
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003609:Dactinomycin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality* / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D014750:Vincristine / Q000627:therapeutic use*; D009396:Wilms Tumor / Q000401:mortality* / Q000628:therapy
chemical_list: D003609:Dactinomycin; D014750:Vincristine
vernacular_title: Verbesserte Prognose beim Wilms-Tumor durch adjuvante Kombinationschemotherapie.