title: Reversion of a promoter deletion in yeast.
abstract: Promoter function in yeast has been examined by obtaining revertants of a his3 promoter deletion in vivo. Events which provide a new promoter for the his3 gene include insertion of the transposable element Ty1, rearrangements of the plasmid vector, and chromosomal mutations. A role for dicentric chromosomes as a source of the plasmid rearrangements is discussed.
mesh_terms: D001483:Base Sequence; D002872:Chromosome Deletion; D004251:DNA Transposable Elements; D004271:DNA, Fungal / Q000235:genetics; D004274:DNA, Recombinant; D005796:Genes; D009154:Mutation; D009876:Operon; D010957:Plasmids; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D015003:Yeasts / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D004271:DNA, Fungal; D004274:DNA, Recombinant