Epigenetic membrane effects of a possible tumor promoting type on cultured liver cells by the non-genotoxic organochlorine pesticides chlordane and heptachlor.
The organochlorine pesticides chlordane and heptachlor were evaluated for their genotoxicity and epigenetic membrane effects. Both compounds were non-genotoxic in the ARLHGPRT mutagenesis assay in which the genotoxic carcinogens 7, 12-dimethylbenz[a]anthracene and benzo[a]pyrene induced significant increases in mutant incidence. The pesticides both markedly inhibited intercellular communication between cultured liver cells, a property demonstrated by many tumor promoting agents, whereas benzo[a]pyrene did not produce this epigenetic effect.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology; D002450:Cell Communication / Q000187:drug effects; D002706:Chlordan / Q000494:pharmacology*; D006533:Heptachlor / Q000494:pharmacology*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D051381:Rats; D011916:Rats, Inbred F344
D001580:Benzopyrenes; D002273:Carcinogens; D009153:Mutagens; D002706:Chlordan; D001564:Benzo(a)pyrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D006533:Heptachlor; D007041:Hypoxanthine Phosphoribosyltransferase