[Rheumatoid synovitis (problems of immunomorphology and immunopathogenesis)].
The immunopathogenesis of rheumatoid synovitis (RS) is assumed to be as follows: antigen X interacts with the organism of subjects genetically predisposed to rheumatoid arthritis (RA) as a result of which the immune response regulation is disturbed ("immunological discomfort") leading to changes in proliferation and differentiation of immunocompetent cells immunologically manifested by disturbed ratios of lymphocyte subpopulations and morphologically by immune inflammation of synovial membranes, i.e. RS. Immune inflammation in RS is a systemic, chronic, persisting, recurrent, self-sustained process based on profound changes in qualitative and quantitative aspects of immunological homoeostasis. The results of the authors' own studies indicate that in the inflammation field (eluates of synovial membrane and synovial fluid) rearrangement of lymphocyte subpopulations is more marked than in the peripheral blood of patients with RA. The quantitative deficiency in eluates of synovial membrane and peripheral blood of T gamma-lymphocytes having the suppressive-cytotoxic function confirms the important role of immunoregulation disturbance in the pathogenesis of RA.
D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology; D000937:Antigen-Antibody Reactions; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D003165:Complement System Proteins / Q000276:immunology; D003450:Cryoglobulins / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology; D007111:Immunity, Cellular; D011509:Proteoglycans / Q000276:immunology; D012217:Rheumatoid Factor / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology / Q000473:pathology; D013585:Synovitis / Q000209:etiology / Q000276:immunology* / Q000473:pathology
D000936:Antigen-Antibody Complex; D003450:Cryoglobulins; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II; D011509:Proteoglycans; D003165:Complement System Proteins; D012217:Rheumatoid Factor
Revmatoidnyĭ sinovit (nekotorye voprosy immunomorfologii i immunopatogeneza).