Leucocyte sodium-potassium adenosine triphosphatase and leukemia.
Na-K ATPase of healthy leucocytes is relatively low (109 +/- 20 nmol . mg-1 . h-1), as is the permeability of the plasma membrane to cations. In this study of leucocytes from leukaemic patients, the Na-K ATPase was increased. There was an associated increase in membrane permeability to sodium and calcium. In one patient, this led to a clinically dangerous and spurious suggestion of hyperkalaemia. It is suggested that some leukaemic conditions may be associated with 'leaky' membranes.
D002118:Calcium / Q000097:blood; D002463:Cell Membrane Permeability; D006801:Humans; D007945:Leukemia, Lymphoid / Q000201:enzymology*; D007962:Leukocytes / Q000201:enzymology*; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium