Spin label electron paramagnetic resonance (EPR) studies of Huntington disease erythrocyte membranes.
Several spin-label electron paramagnetic resonance (EPR) studies of red cell membranes appear to show abnormalities in some Huntington disease (HD) patients, but not in others. Both studies measure the W/S ratios, presumably under similar conditions, but have different results. We have studied the W/S ratio in some detail to gain a better understanding of this experimental parameter and to determine its potential application in detecting HD abnormalities. Our results offer little encouragement for continued use of W/S as an indication of membrane defect in HD.
D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000032:analysis*; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000097:blood* / Q000235:genetics; D008297:Male; D013113:Spin Labels
D013113:Spin Labels