title: [Mechanisms of the toxic effect of benz(a)pyrene and its derivatives in tissue culture].
abstract: Study in cell cultures of toxic action and metabolism of benz(a)pyrene and its derivatives substituted in the 6th position has shown that the toxic effect of the compounds depends on the substituent moiety. No correlation has been disclosed between toxicity and metabolism intensity. It is suggested that toxic action of benz(a)pyrene and its 6-substituted is determined by epoxide formation in the 4th-5th position.
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism / Q000494:pharmacology*; D002478:Cells, Cultured; D005347:Fibroblasts; D051379:Mice; D008809:Mice, Inbred C3H / Q000196:embryology; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D001580:Benzopyrenes; D001564:Benzo(a)pyrene
vernacular_title: Izuchenie mekhanizma toksicheskogo deĭstviia benz(a)pirena i ego proizvodnykh v kul'ture tkaneĭ.