title: Studies on a vaccine against infections bursal disease.
abstract: An infectious bursal disease vaccine, registered for use in breeder flocks, was studied for efficacy on the day-old offspring of vaccinated hens and for virulence in susceptible day-old and 6-week-old chickens. When given to susceptible day-old chicks and 6-week-old cockerels, the vaccine was found to induce atrophy and pathology of the bursa of Fabricius similar to that observed in field infections. Chicks vaccinated at day-old had markedly lowered titres in the haemagglutination inhibition test to Newcastle disease virus, when this was given 2 weeks later, but the response of the 6-week-old cockerel was similar to that of control birds. Maternal antibody induced by the vaccine protected chicks against infection at day-old.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002645:Chickens; D002986:Clinical Trials as Topic / Q000662:veterinary; D003228:Conjunctiva; D007243:Infectious bursal disease virus / Q000276:immunology*; D008297:Male; D011201:Poultry Diseases / Q000517:prevention & control*; D011233:Precipitin Tests / Q000662:veterinary; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines