Oncogenic activity of the BK type of human papova virus in newborn Wistar rats.
The oncogenic potential of the human papova virus BK (= BKV) has been examined in newborn Wistar rats. 12 of 37 animals inoculated with BKV s.c. and 7 of 40 animals inoculated with BKV i.c. developed tumors of various histological types. The latency periods ranged from 6 to 18 months. The BKV etiology of tumors was supported by detection of BKV T antigen in cells of established tumor lines by means of indirect immunofluorescence. No tumors appeared in animals given injections of saline instead of virus. BKV T antibodies were detected in sera of 100 per cent of animals bearing tumors but no in sera of control animals. Only 3 of 77 BKV infected and none of the control animals developed spontaneous tumors (adenomas).
D000818:Animals; D000831:Animals, Newborn; D000912:Antibodies, Neoplasm / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D000957:Antigens, Viral, Tumor; D001739:BK Virus / Q000276:immunology / Q000472:pathogenicity*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000473:pathology; D011120:Polyomavirus / Q000472:pathogenicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014412:Tumor Virus Infections
D000912:Antibodies, Neoplasm; D000914:Antibodies, Viral; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor