Increased ability of human embryonic fibroblasts to accumulate Ca2+ due to cytomegalovirus infection.
Cytomegalovirus infection of fibroblasts enhances the ability of these cells to accumulate Ca2+. This functional alteration precedes the development of the cytopathic effect, and it is proposed that increased intracellular Ca2+ concentration may initiate the rounding phenomenon. Changes in the aggregative behaviour and the antigenicity of the infected cells were seen to accompany this functional alteration.
D000956:Antigens, Viral / Q000032:analysis; D002118:Calcium / Q000378:metabolism*; D002449:Cell Aggregation; D002462:Cell Membrane / Q000276:immunology / Q000648:ultrastructure; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000254:growth & development* / Q000276:immunology; D003588:Cytopathogenic Effect, Viral; D005347:Fibroblasts / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D008871:Microvilli / Q000648:ultrastructure
D000956:Antigens, Viral; D002118:Calcium