[Effect of carbacholine on miniature potentials and currents of rat skeletal muscle endplates].
In rat soleus muscle placed in solution with 13 mumol/l potassium chloride carbachol (10 mumol/l) caused a marked increase in miniature end-plate potentials frequency. Intensification of spontaneous mediator release was also observed under clamping of the membrane potential of the muscle fibre at potassium equilibrium potential level. It is concluded that carbachol presynaptic effect on spontaneous acetylcholine release is not connected with postsynaptic membrane depolarization and results from direct mimetic action on the motor nerve terminals.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009045:Motor Endplate / Q000187:drug effects* / Q000502:physiology; D009046:Motor Neurons / Q000378:metabolism; D009469:Neuromuscular Junction / Q000187:drug effects*; D011188:Potassium / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects
D002217:Carbachol; D000109:Acetylcholine; D011188:Potassium
Vliianie karbakholina na miniatiurnye potentsialy i toki kontsevoĭ plastinki skeletnoĭ myshtsy krysy.