title: Transposable elements controlling genetic instabilities in mammals.
abstract: It is proposed that the instabilities in gene action of some alleles at certain loci in the mouse (e.g., a, c, H-2 Mi, p, pe, T, Va, W), which do not seem to conform to traditional hypotheses of gene action, are better interpretable in the light of modern studies of transposable DNA elements (insertion sequences and transposons of prokaryotic organisms; controlling elements of maize; transposable controlling elements of Drosophila). Some phenotypic evidence in the mouse in support of this hypothesis is presented for the a, Mi, p, and W loci, which affect pigmentation.
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements; D004285:Dogs; D004330:Drosophila / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D010641:Phenotype; D010858:Pigmentation; D003313:Zea mays / Q000235:genetics
chemical_list: D004251:DNA Transposable Elements