title: Decrease of oxygen difference between arterial blood and cerebrospinal fluid after intravenous injection of sodium bicarbonate in hyperoxic patients, anaesthetized, paralyzed and artificially ventilated.
abstract: In the subjects being prepared to neurosurgical treatment an i.v. injection of NaHCO3 (2 mEq/kg) elicited a significant increase in PCSFO2 from 69 +/- 6.4 (SEM) Torr to 75.5 +/- 3.9 (SEM) Torr. This change ws accompanied by a significant drop of PaO2 from 150.5 +/- 6.0 Torr to 138.0 +/- 5.8 Torr. Metabolic alkalosis (pH 7.54 +/- 0.02 SEM) elicited by bicarbonate administration was accompanied by arterial blood hyperoxia. Both these factors reduce the cerebral flow (CBF). We suppose that changes in the blood--CSF oxygen relationship reflect the presence of a mechanism which might protect the CNS against a decrease in CBF.
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D001639:Bicarbonates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood* / Q000134:cerebrospinal fluid*; D010243:Paralysis / Q000209:etiology; D012121:Respiration, Artificial; D017693:Sodium Bicarbonate; D013390:Succinylcholine / Q000008:administration & dosage
chemical_list: D001639:Bicarbonates; D017693:Sodium Bicarbonate; D013390:Succinylcholine; D010100:Oxygen