title: Further studies on the absorption of actinide elements from the gastrointestinal tract of neonatal animals.
abstract: Plutonium retention was measured after intragastric administration to neonatal rats, dogs and swine. At 1 week after administration, substantially more of the actinide remained in swine and dogs than in rats. The quantity of 238Pu absorbed by piglets was markedly influenced by such factors as compound solubility, mass of plutonium administered, oxidation state of the actinide, and age of the animal at gavage. Cortisone treatment reduced absorption, but was less effective in piglets than in neonatal rats. Measurements of 238Pu transport from ligated segments of the neonatal swine intestine indicated highest absorption from the duodenum, where the actinide was shown, autoradiographically, to be deposited in the epithelial region; in the ileum, deposition was predominantly in the lacteal region. Absorption of actinides by neonatal swine decreased in the order of 233U greater than 238Pu greater than 237Np greater than 244Cm greater than 241Am. Measurements at 1 yr after gavage showed a much higher retention by swine than by rats.
mesh_terms: D008671:Actinoid Series Elements / Q000378:metabolism*; D000576:Americium / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D003476:Curium / Q000378:metabolism; D004285:Dogs; D007408:Intestinal Absorption; D009405:Neptunium / Q000378:metabolism; D011005:Plutonium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine; D014018:Tissue Distribution; D014501:Uranium / Q000378:metabolism
chemical_list: D008671:Actinoid Series Elements; D014501:Uranium; D011005:Plutonium; D009405:Neptunium; D003476:Curium; D000576:Americium