Nitrosamine-induced transplantable pancreatic ductal adenocarcinoma in inbred Syrian hamsters.
A pancreatic ductal carcinoma, designated CBP, was established as a transplantable tumor line in the CB/SsLak inbred strain of Syrian golden hamsters. The tumor, a primary one induced by chronic administration of the nitrosamine N-nitro-bis(2-hydroxyproyl) amine, is a well-differentiated adenocarcinoma that can be propagated by transplantation in syngeneic hamsters. It grows poorly in other hamster strains. The CBP tumor develops in a predictable quantitative manner and metastasizes to regional lymph nodes. Excision of primary transplanted tumor nodules leads to immunity against subsequent secondary tumor challenges. The CBP tumor appears to be a suitable model for biologic and immunologic studies of pancreatic carcinoma in the syrian hamster.
D000818:Animals; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D002460:Cell Line; D006224:Cricetinae; D004195:Disease Models, Animal; D007114:Immunization; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity*; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
D009602:Nitrosamines; C012457:diisopropanolnitrosamine