[Effect of imizin and transamine on the bioelectrical activity of the ventrolateral columns of the spinal cord].
It was established in experiments on spinal rats that imizine (2.5-10 mg/kg) decreased spontaneous activity and that evoked by stimulation of the sciatic nerve and intraarterial injection of bradykinin in the dorsal horns and ventrolateral columns of the spinal cord. Transamine (1-5 mg/kg) reduced the evoked activity in the dorsal horns and ventrolateral columns but potentiated spontaneous activity in these structures. Naloxone (1 mg/kg) reduced the effect of imizine (5 mg/kg) on the bradykinin-induced nociceptive activity in the ventrolateral columns of the spinal cord.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000187:drug effects; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D014148:Tranexamic Acid / Q000494:pharmacology*
D000928:Antidepressive Agents; D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid; D007099:Imipramine
Vliianie imizina i transamina na bioélektricheskuiu aktivnost' v ventrolateral'nykh stolbakh spinnogo mozga.