Effects of oral atenolol and propranolol on blood pressure, heart rate and plasma cyclic adenosine 3':5'-monophosphate in borderline hypertensive patients.
The effects of oral treatment with atenolol and propranolol on blood pressure, heart rate and plasma cyclic adenosine 3':5'-monophosphate (cAMP) were studied in a group of young borderline hypertensives. Observations were accomplished after a period of recumbent relaxation and also following physiological stress testing. The latter significantly increased blood pressure, heart rate and plasma cAMP. A direct relationship was found between heart rate and plasma cAMP at rest and also following psychological stress. This relationship was lost following drug treatments. Both beta-blockers significantly reduced all measured variables in both conditions. However, plasma cAMP was most affected by propranolol.
D000293:Adolescent; D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D000242:Cyclic AMP / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology
D011412:Propanolamines; D001262:Atenolol; D011433:Propranolol; D000242:Cyclic AMP