title: Autoradiographic localization of opiate kappa-receptors in the guinea-pig brain.
abstract: Opiate binding sites of the kappa-subtype were visualized in guinea-pig brain sections using in vitro autoradiography. kappa-Binding sites, defined as [3H](-)-bremazocine binding in the presence of high concentrations of [D-Ala2,MePhe4,Gly-ol5]enkephalin and [D-Ala2,D-Leu5]enkephalin, were found in the cortical laminae V and VI, hippocampal dentate gyrus, and lateral habenulae. The distribution of kappa-sites in the guinea-pig differs considerably from the distribution of mu- and delta-sites which others have found in the rat.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001575:Benzomorphans / Q000031:analogs & derivatives; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives; D016308:Enkephalin, Leucine-2-Alanine; D004745:Enkephalins; D006168:Guinea Pigs; D007033:Hypothalamus, Middle / Q000378:metabolism; D008297:Male; D011957:Receptors, Opioid / Q000378:metabolism*; D017473:Receptors, Opioid, kappa
chemical_list: D001575:Benzomorphans; D004745:Enkephalins; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C027248:bremazocine