title: Adrenal Size and function after irradiation with 131I-6 beta-Iodocholesterol in rabbits.
abstract: Administration of high doses of 131I-6 beta-iodocholesterol to rabbits is followed by marked size reduction of the adrenal glands with concomitant changes of the histological structure and with a decrease of serum cortisol. Stimulation of 131I-6 beta-iodocholesterol uptake into the adrenals by additional administration of ACTH had only a minor additional effect on adrenal weight. However, with further accumulation of labeled cholesterol in the adrenals the radioactivity was reduced in blood urine, and the ovaries.
mesh_terms: D000311:Adrenal Glands / Q000033:anatomy & histology / Q000528:radiation effects*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007457:Iodine Radioisotopes / Q000494:pharmacology*; D007668:Kidney / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D009929:Organ Size / Q000528:radiation effects; D010053:Ovary / Q000033:anatomy & histology; D011817:Rabbits; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D014284:Triiodothyronine; C016523:6-iodocholesterol; D000324:Adrenocorticotropic Hormone; D002784:Cholesterol; D013974:Thyroxine; D006854:Hydrocortisone