title: The PHI (PHI-27)/corticotropin-releasing factor/enkephalin immunoreactive hypothalamic neuron: possible morphological basis for integrated control of prolactin, corticotropin, and growth hormone secretion.
abstract: By using the indirect immunofluorescence technique, one and the same neuron in the parvocellular part of the paraventricular nucleus has been shown to stain with antisera against three different peptides: PHI (PHI-27), corticotropin-releasing factor (CRF), and enkephalin. This could explain the well-known parallel increase in plasma prolactin, corticotropin, and growth hormone levels--for example, under certain types of stress--as being due to a concomitant release of PHI-like, CRF-like, and enkephalin-like peptides from the same nerve endings in the median eminence. A hypothetical mechanism for the co-ordinated release of these three anterior pituitary hormones is discussed.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D001931:Brain Mapping; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D013006:Growth Hormone / Q000378:metabolism; D007031:Hypothalamus / Q000166:cytology* / Q000502:physiology; D008297:Male; D010451:Peptide PHI; D010455:Peptides / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism; D051381:Rats
chemical_list: D004745:Enkephalins; D010451:Peptide PHI; D010455:Peptides; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone; D003346:Corticotropin-Releasing Hormone