Assignment of the human phosphoserine phosphatase gene (PSP) to the pter leads to q22 region of chromosome 7.
Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. PSP expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Human PSP is expressed only when the pter leads to q22 segment of the human 7 and its enzyme marker beta-glucuronidase (GUSB) are retained in cell hybrids. The structural gene, PSP, is therefore assigned to this region of the human 7.
D000818:Animals; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D002999:Clone Cells; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D051379:Mice; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*
D010744:Phosphoric Monoester Hydrolases; C022394:phosphoserine phosphatase