Effect of protein synthesis inhibition on the induction of cell lysis in Escherichia coli by mecillinam plus nocardicin A.
Cell lysis can be induced in Escherichia coli by the combined use of the beta-lactam antibiotics nocardicin A and mecillinam. Apparently, the induction of cell lysis occurs by a sequential mechanism in which mecillinam acts first, and nocardicin A has a triggering action insensitive to the inhibition of protein synthesis.
D000560:Amdinocillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D002701:Chloramphenicol / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D007769:Lactams; D010397:Penicillanic Acid / Q000494:pharmacology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D007769:Lactams; D002701:Chloramphenicol; C027318:nocardicin; D010397:Penicillanic Acid; D000560:Amdinocillin