[Insulin binding to isolated thyroid plasma membrane].
Binding sites of insulin were detected in plasmic membranes isolated from bovine thyroid. Membrane 123I-insulin binding was inhibited by unlabelled insulin, at a lower degree by proinsulin, not at all by TSH and GH. Binding dissociation appeared to be consistent with the process of cooperative negativity. These data suggest that specific receptors binding to insulin are present in thyroid isolated plasmic membranes.
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D003012:Microbial Collagenase / Q000494:pharmacology; D011384:Proinsulin / Q000494:pharmacology; D011972:Receptor, Insulin / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism*
D007328:Insulin; D011384:Proinsulin; D011972:Receptor, Insulin; D003012:Microbial Collagenase
Liaison de l'insuline aux membranes plasmiques isolées thyroïdiennes.