Effects of ACTH4-10 on vestibular compensation.
ACTH4-10, a fragment of the adrenocorticotropic hormone (ACTH) molecule, has marked effects on the compensation process following unilateral labyrinthectomy. In Rana temporaria ACTH4-10-treatment (5-250 micrograms/kg) influences both the acquisition and the maintenance of the compensated state. The compensation process is slowed down by hypophysectomy but can then be restored by the administration of ACTH4-10. It is concluded that ACTH-like neuropeptides might physiologically be involved in the plastic processes underlying functional recovery from CNS lesions.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007758:Ear, Inner / Q000294:innervation; D009416:Nerve Regeneration / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D010902:Pituitary Gland / Q000502:physiology; D004856:Postural Balance / Q000187:drug effects*; D011896:Rana temporaria; D014726:Vestibular Nuclei / Q000187:drug effects*
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)