title: Coir fibre toxicity: in vivo and in vitro studies.
abstract: The biological activity of coir fibre, coir ash and their components were investigated in vitro by measuring the haemolytic activity and macrophage cytotoxicity. In vivo studies carried out by injecting guinea pigs intratracheally with coir fibres resulted in resolving granulomas. The observed haemolytic activity and macrophage cytotoxicity was more marked with coir ash compared with coir fibres. Chemical analysis of coir ash revealed the presence of toxic chemical constituents in appreciable amounts.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003059:Cocos / Q000633:toxicity*; D004391:Dust; D004917:Erythromycin / Q000378:metabolism; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects; D008670:Metals / Q000032:analysis; D011009:Pneumoconiosis / Q000209:etiology*; D011650:Pulmonary Alveoli / Q000378:metabolism; D012822:Silicon Dioxide / Q000032:analysis
chemical_list: D004391:Dust; D008670:Metals; D004917:Erythromycin; D012822:Silicon Dioxide