Giant granules and rod-shaped inclusions arising de novo in monocytes and macrophages cultured from a patient with acute monocytic leukemia.
In this paper we describe the de novo appearance of azurophilic giant granules and rod-shaped inclusions in monocytes and macrophages grown from the peripheral blood and bone marrow of a patient with acute monocytic leukemia; no such inclusions were evident in direct smears of the patient's peripheral blood or bone marrow. The cytochemical profile of the inclusions, their origin in mononuclear phagocytes only, and their development exclusively in vitro suggest that they are distinct from Auer rods, Chediak-Higashi-like giant granules, and other abnormal azurophilic inclusions previously described in patients with acute non-lymphocytic leukemia.
D000293:Adolescent; D001399:Azure Stains; D002478:Cells, Cultured; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D007948:Leukemia, Monocytic, Acute / Q000473:pathology*; D008264:Macrophages / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D009000:Monocytes / Q000648:ultrastructure*
D001399:Azure Stains