Adrenergic ligand liposolubility in membranes. Direct assessment in a beta-adrenergic binding system.
The binding of [3H]dihydroalprenolol to adipocyte membranes may be displaced not only from beta-adrenergic receptors but also nonstereospecifically from other membrane compartments by beta-adrenergic and other adrenergic agents. The EC50 of this nonstereospecific displaceable binding is directly related to the liposolubility (n-octanol:water partition coefficient) of the displacing ligand.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D004082:Dihydroalprenolol; D007545:Isoproterenol / Q000378:metabolism; D008024:Ligands; D008563:Membrane Lipids; D008566:Membranes / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012995:Solubility; D013566:Sympathomimetics / Q000378:metabolism*
D008024:Ligands; D008563:Membrane Lipids; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D013566:Sympathomimetics; D004082:Dihydroalprenolol; D007545:Isoproterenol