Release of [3H]noradrenaline from descending tracts in the cat spinal cord in vivo.
The release of [3H]noradrenaline into the perfused central canal of the cat lumbar-sacral spinal cord was monitored in vivo. Stimulation of descending tracts produced an increase efflux into artificial cerebrospinal fluid containing 10(-6) M phenoxybenzamine which could be dissociated from any concurrent rise in blood pressure. No release was produced by stimulating dorsal roots over the length of cord perfused. It appears, therefore, that noradrenaline can be released from descending nerve terminals, but not from dorsal root afferents in the spinal cord.
D000344:Afferent Pathways / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D002415:Cats; D004558:Electric Stimulation; D005727:Ganglia, Spinal / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*; D009435:Synaptic Transmission
D009638:Norepinephrine