Effect of rifampin, levamisole, and cytoplasmic protein antigen from Mycobacterium microti on 5'-nucleotidase production by guinea pig macrophages.
A decline in 5'-nucleotidase production was observed in short-term tissue culture of guinea pig alveolar, peritoneal, splenic, and liver macrophages during exposure to 10(2) microM rifampicin, 1 microM levamisole, or 10 micrograms of cytoplasmic protein antigen extracted from Mycobacterium microti. Liver macrophage 5'-nucleotidase production was more significantly inhibited by the three agents. Cytoplasmic protein antigen from M. microti was the most potent inhibitor of 5'-nucleotidase production.
D000818:Animals; D000942:Antigens, Bacterial / Q000302:isolation & purification; D001202:Ascitic Fluid / Q000166:cytology; D001426:Bacterial Proteins / Q000494:pharmacology*; D002478:Cells, Cultured; D004790:Enzyme Induction / Q000187:drug effects; D006168:Guinea Pigs; D007978:Levamisole / Q000494:pharmacology*; D008099:Liver / Q000166:cytology; D008264:Macrophages / Q000201:enzymology*; D009161:Mycobacterium / Q000187:drug effects / Q000201:enzymology* / Q000276:immunology; D009708:Nucleotidases / Q000096:biosynthesis*; D011650:Pulmonary Alveoli / Q000166:cytology; D012293:Rifampin / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007978:Levamisole; D009708:Nucleotidases; D012293:Rifampin