Does conditioned nausea mediate drug-induced conditioned taste aversion?
Two antiemetic drugs were tested on the expression of taste aversions previously conditioned in rats with lithium, amphetamine or morphine. Neither prochlorperazine nor scopolamine administered prior to testing attenuated established aversions, although both drugs are known to have antiemetic effects in other species. Negative findings were obtained with a range of dose of prochlorperazine and scopolamine, with strong and weak aversions, with one- and two-stimulus tests, in a repeated one-stimulus extinction procedure, with between- and within-group designs and with hooded, albino, male and female rats. The results do not support the widely accepted hypothesis that conditioned nausea mediates conditioned taste aversion.
D000661:Amphetamine / Q000506:poisoning; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002712:Chlorides / Q000506:poisoning; D003214:Conditioning, Classical / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects; D005260:Female; D008094:Lithium / Q000506:poisoning; D018021:Lithium Chloride; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009115:Muridae; D009325:Nausea / Q000139:chemically induced*; D011346:Prochlorperazine / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*
D002712:Chlorides; D009020:Morphine; D008094:Lithium; D000661:Amphetamine; D012601:Scopolamine; D018021:Lithium Chloride; D011346:Prochlorperazine