title: [Venous thrombosis, circulating anticoagulant and systemic lupus erythematosus. Two cases reported in two identical HLA sisters (author's transl)].
abstract: The observation of two cases of thrombophlebitis of the calf which occurred in two sisters within a period of three years is reported. The investigation revealed in both cases the presence of a circulating anticoagulant with anti-prothrombinase activity in association with biological signs of systemic lupus erythematosus (L.E.): anti-DNA antibodies, decreased complement levels, false positive BW reactions. In one patient, the skin biopsy showed a continuous IgM band on immuno-fluorescence. After respectively 4 years and 18 months follow-up both patients are still free from clinical symptoms. A review of the literature is presented and the clinical and etiological significance of the presence of a circulating anticoagulant, its relationship with L.E., particularly with "latent" L.E. (presence of biological signs only), and its association with thrombophlebitis are discussed.
mesh_terms: D001777:Blood Coagulation; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000235:genetics / Q000276:immunology; D013924:Thrombophlebitis / Q000097:blood* / Q000175:diagnosis / Q000235:genetics
chemical_list: D006680:HLA Antigens
vernacular_title: Thromboses veineuses, anticoagulant circulant et lupus érythémateux dissémine. A propos de deux cas chez deux soeurs HLA identiques.