Unusual serologic response to two patients to an early antigen of herpes simplex virus type 2.
Two patients infected with herpes simplex virus type 2 (HSV-2) who were free of recurrences over a 13-14-month period had an unusually high titer (greater than 1:48) of complement-fixing antibody to the early antigen (AG-4) of HSV-2. Their response was also unusual in that it was an IgG complement-fixing antibody rather than IgM, which normally is found in patients with HSV-2 infection. The antibody was also present 13-14 months after the episode of HSV-2 disease, whereas in other patients, the response had declined by six months.
D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000276:immunology*; D003168:Complement Fixation Tests; D005260:Female; D006558:Herpes Genitalis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D018139:Simplexvirus / Q000276:immunology*; D013997:Time Factors
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007074:Immunoglobulin G