title: Effect of immune heterozygous spleen cell transfer on resistance to mouse hepatitis virus infection in nude mice.
abstract: The role of cell mediated immune response to mouse hepatitis virus (MHV) infection in mice was studied by transferring spleen cells from immune heterozygous littermates (nu/+). A suppressive effect on viral growth was seen in infected nude (nu/nu) mice, whereas immune nu/+ serum transfer had no effect. The protective effect of immune nu/+ spleen cells was significantly reduced by treatment with anti-theta serum plus complement but not with anti-Ig serum. In infected nu/nu mice which received transfers of immune nu/+ cells, neutralizing antibody appeared although the titer was not high enough to protect nu/nu mice from fatal infection. Histopathologically, lymphocyte infiltration in hepatic lesions was evident in infected nu/nu mice with nu/+ cell transfer, while it was slight without nu/+ cell transfer.
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral / Q000032:analysis; D000961:Antilymphocyte Serum / Q000494:pharmacology; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000276:immunology* / Q000473:pathology; D006579:Heterozygote; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D008819:Mice, Nude; D006517:Murine hepatitis virus / Q000276:immunology; D009500:Neutralization Tests; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D000961:Antilymphocyte Serum