Necrotizing myopathy associated with steroid therapy. Report of two cases.
A range of histological lesions was found in necropsy samples of skeletal muscle from 2 patients on steroid therapy. There were perifascicular necroses, regeneration, atrophy, and sclerosis. These findings disagree with published data from human material; however, they are similar to observations made in experimentally induced steroid myopathy in rabbits.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D001284:Atrophy; D002544:Cerebral Infarction / Q000188:drug therapy; D003907:Dexamethasone / Q000009:adverse effects; D005909:Glioblastoma / Q000188:drug therapy; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology*; D009336:Necrosis
D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D006854:Hydrocortisone