title: Pathogenicity and distribution of egg-drop syndrome-1976 virus (JPA-1) in inoculated laying hens.
abstract: Rhode Island Red laying hens that lacked hemagglutination-inhibition antibody were inoculated orally with the JPA-1 strain of adenovirus isolated from a flock affected with egg-drop syndrome-1976 in Japan and observed for 80 days. Inoculated hens laid abnormal eggs, such as shell-less, soft-shelled, and cracked eggs and those with loss of pigmentation, from 8 days postinoculation (PI). Fifteen out of 16 hens laid abnormal eggs. Egg-production rte fell from 94% to 50% between 13 and 16 days PI. When the abnormal eggs were excluded, egg production was 17%; then it recoverd slowly, reaching 67% by the end of the experiment. The virus was recovered from various organs of inoculated hens from 3 to 7 days PI. Fluorescent antigens of the virus were observed in the epithelial cells and desquamated cells from the epithelium of the uterus and isthmus 10 and 14 days PI.
mesh_terms: D000257:Adenoviridae Infections / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000259:Aviadenovirus / Q000276:immunology; D002645:Chickens; D004531:Eggs; D005260:Female; D011201:Poultry Diseases / Q000209:etiology* / Q000276:immunology; D013577:Syndrome / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral