Studies on the transmission of human hepatitis A virus to stump-tailed monkey.
The newly-caught stump-tailed monkeys (Macaca speciosa) with negative antibody to hepatitis A were inoculated with human hepatitis A virus. The following findings were observed in the monkeys after inoculation: (i) the elevation of activities of the serum glutamic-pyruvic transaminase, lactate dehydrogenase and its isoenzyme (LDH5), (ii) the seroconversion of antibody to hepatitis A virus. (iii) the shedding of hepatitis A antigen in feces. These findings show that the stump-tailed monkey (Macaca speciosa) is susceptible to infection of human hepatitis A virus. The virus recovered from the feces of the infected monkey, named as Hang-zhou A-1A strain of hepatitis A virus, has experienced two generations of successful transmission in monkeys.
D000818:Animals; D000917:Antibody Formation; D000956:Antigens, Viral / Q000032:analysis; D004195:Disease Models, Animal; D005243:Feces / Q000032:analysis / Q000382:microbiology; D006506:Hepatitis A / Q000635:transmission*; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D008251:Macaca
D000956:Antigens, Viral