[Effect of thallium on enzyme activity and unidirectional sodium transport in frog skin].
The cytophotometric analysis of enzyme activity in the frog skin epithelium has shown that Tl+ accumulated by cells at millimolar concentrations causes a 70-80% inhibition of both succinate and alpha-ketoglutarate dehydrogenases, while the activity of Na, K-ATPase decreased only slightly. The opposite situation was true for the ouabain treatment. The accumulation of Tl+ by frog skin caused a substantial swelling of mitochondria. It is suggested that the earlier observed inhibition of the unidirectional Na+ transport by Tl+ might be resulted from a blocking of oxidative metabolism. The same cells poisoned by Tl+ were able to maintain their ion composition presumably at the expense of glycolysis.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D006651:Histocytochemistry; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D010042:Ouabain / Q000494:pharmacology; D011896:Rana temporaria; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013793:Thallium / Q000494:pharmacology*
D010042:Ouabain; D012964:Sodium; D013793:Thallium; D007655:Ketoglutarate Dehydrogenase Complex; D013385:Succinate Dehydrogenase; D000254:Sodium-Potassium-Exchanging ATPase
Vliianie talliia na aktivnost' fermentov i odnonapravlennyĭ transport natriia v kozhe liagushki.