Changes in noradrenergic neurotransmission in rat cerebellum during aging.
This study compared the electrophysiological effects of locally applied cyclic adenosine-mono-phosphate (N6cAMP) between Purkinje neurons from young (4-month) and old rats (15-months and older). Purkinje neurons from young rats were significantly more sensitive to locally applied norepinephrine and N6cAMP than neurons from old rats. GABA sensitivity between the two groups was unaltered. Our results suggest that the locus of the adrenergic subsensitivity observed in older animals may reside to a large extent at or beyond the level of cAMP generation.
D000375:Aging; D000818:Animals; D002531:Cerebellum / Q000187:drug effects*; D000242:Cyclic AMP / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D011689:Purkinje Cells / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission
D000242:Cyclic AMP; D009638:Norepinephrine