Induction and augmentation of mitogen-induced immune interferon production in human peripheral blood lymphocytes by N alpha-desacetylthymosin alpha 1.
Treatment of human peripheral blood lymphocytes with cloned N alpha-desacetylthymosin alpha 1 induced interferon production. The kinetics is similar to that of mitogen-induced interferon induction. N alpha-desacetylthymosin alpha 1, in combination with mitogen, augments the amount of interferon produced. This interferon is immune interferon (IFN-gamma) as determined by sensitivity to pH 2, lack of neutralization by antibodies to IFN-alpha or IFN-beta and absence of activity of MDBK cells. Although the mechanism of induction of IFN-gamma by N alpha-desacetylthymosin alpha 1 is unclear, this compound is not mitogenic at concentrations causing IFN-gamma production. These results indicate that thymic factors may also participate in the regulation of IFN-gamma-production.
D002478:Cells, Cultured; D006801:Humans; D007369:Interferon Inducers; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D008934:Mitogens; D013947:Thymosin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development
D007369:Interferon Inducers; D008934:Mitogens; D013951:Thymus Hormones; D013947:Thymosin; C026456:desacetylthymosine alpha(1)