title: Humoral and cell-mediated immune responses in chickens with infectious bursal disease.
abstract: Primary and secondary immune responses to Newcastle disease virus (NDV) was evaluated in chickens infected with infectious bursal disease virus (IBDV) at one and 28 days of age. The geometric mean primary hemagglutination-inhibition antibody titers (GMT) of chickens infected with IBDV at one day of age was significantly lower (P less than or equal to 0.01) than those infected at 28 days of age. Infection with IBDV had no influence on secondary immune response to NDV. The effect of IBDV infection at one day of age on the cell-mediated immunity of chickens was evaluated by skin allograft acceptance or survival time. There was no significant difference between the percentage of grafts accepted in IBDV infected and noninfected control chickens. However, the mean graft survival time in the IBDV infected chickens was significantly longer (P less than or equal to 0.05) than those in the control group. This suggested a suppression of cell-mediated immunity due to IBDV infection.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D002645:Chickens / Q000276:immunology*; D007111:Immunity, Cellular; D007243:Infectious bursal disease virus; D009522:Newcastle disease virus / Q000276:immunology; D011201:Poultry Diseases / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral