Dorsal root potentials in the cat: effects of bicuculline.
Bicuculline (0.2 1 mg/kg) administered intravenously depressed dorsal root potentials (DRPs) evoked by stimulation of mixed, pure muscle or pure cutaneous nerves which was clearly concurrent with enhanced background potentials in intact cat. Administration of sodium pentobarbitone (15-30 mg/kg i.v.) reduced the ability of bicuculline to enhance background potentials and to depress evoked DRPs. In spinalized preparations, bicuculline depression of evoked DRPs by bicuculline in intact cat may not result from its action at axo-axonic GABAergic synapses alone and occlusion may also play a part. However, the role of gamma-aminobutyric acid (GABA) in primary afferent depolarization is confirmed in the spinalized preparations.
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D002415:Cats; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005727:Ganglia, Spinal / Q000187:drug effects*; D009433:Neural Inhibition / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*; D013979:Tibial Nerve / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005680:gamma-Aminobutyric Acid; D001640:Bicuculline