title: Experimental maedi virus infection in sheep: early cellular and humoral immune response following parenteral inoculation.
abstract: The early immune response (19 weeks) in sheep inoculated parenterally with maedi virus was studied, using the lymphocyte transformation test, immunodiffusion test, complement-fixation test, and neutralization test. Cellular immune responses were detected between 3 and 7 weeks after the sheep were inoculated. Antibodies were detected by immunodiffusion test in 3 of 5 animals in weeks 7 to 11 and by complement-fixation test in weeks 15 to 19. Neutralizing antibodies were not detected. There was no sign of virus-induced immunosuppression as determined by lymphocyte responsiveness to mitogens or by in vivo and in vitro immune responses following BCG vaccination.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008934:Mitogens / Q000494:pharmacology; D011021:Pneumonia, Progressive Interstitial, of Sheep / Q000276:immunology*; D012756:Sheep; D013997:Time Factors; D014790:Visna-maedi virus / Q000276:immunology
chemical_list: D001500:BCG Vaccine; D008934:Mitogens