Release of eosinophil chemotactic leukotriene from neutrophils of patients with pseudo-allergic reactions.
Possible alterations in the release of eosinophil chemotactic leukotrienes (ECL) were studied with leukocytes from 14 patients with chronic urticaria due to pseudo-allergic reactions (PAR) and from 14 healthy volunteers. Patients tended to release less ECL, and inhibition of ECL release was more marked in the presence of cyclooxygenase and lipoxygenase inhibitors. The latter compounds did not cause ECL secretion by themselves. Increased release of lipoxygenase products of arachidonate metabolism from blood leukocytes is therefore an unlikely cause for PAR.
D002630:Chemotactic Factors / Q000378:metabolism*; D002631:Chemotactic Factors, Eosinophil / Q000378:metabolism*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007975:Leukotriene B4 / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D014581:Urticaria / Q000276:immunology* / Q000378:metabolism
D002630:Chemotactic Factors; D002631:Chemotactic Factors, Eosinophil; D007975:Leukotriene B4; D007213:Indomethacin