The role of the human major histocompatibility complex in cytotoxic T-cell responses to virus-infected cells.
The human major histocompatibility complex (HLA) has been demonstrated to play two roles in the generation and expression of cytotoxic T-lymphocyte responses to virus-infected cells: (1) cytotoxic T cells can only recognize viral antigens in conjunction with antigens encoded by HLA-A and -B genes; and (2) HLA-linked genes may control the capacity to generate T-cell responses to a given virus or to virus in conjunction with particular self HLA-A and -B antigens. Analysis of T-cell responses generated in vivo to Epstein-Barr virus suggests that human T cells may recognize virus in conjunction with antigens other than the class I HLA polymorphic specificities.
D002874:Chromosome Mapping; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology; D007251:Influenza, Human / Q000235:genetics / Q000276:immunology; D008285:Major Histocompatibility Complex; D008459:Measles virus / Q000235:genetics / Q000276:immunology; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II