title: [Effect of duration of the intervals between immunization with DPT vaccine on the serological indices in children].
abstract: The influence of the interval between injections of adsorbed DPT vaccine on the effectiveness of immunization has been studied. The intensity of antibody formation to the pertussis component has been found to decrease 2.7-3.7 times if the interval between the injections constituting the course of primary immunization is prolonged for more than 6 months. The interval between the course of primary immunization and the first booster injection, which lasts 1.5-2 years in accordance with the currently accepted immunization schedule, is unreasonably long. Immunological characteristics in respect to pertussis have been found to decrease 8-45 times as early as 16 months after the first booster injection. Most of the vaccines catching pertussis at that time had the moderately severe form of this infection.
mesh_terms: D000367:Age Factors; D000907:Antibodies, Bacterial / Q000032:analysis*; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D010567:Pertussis Vaccine / Q000008:administration & dosage*; D013745:Tetanus Toxoid / Q000008:administration & dosage*; D013997:Time Factors; D014917:Whooping Cough / Q000097:blood / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid
vernacular_title: Vliianie prodolzhitel'nosti intervalov mezhdu privivkami AKDS-vaktsiny na serologischeskie pokazateli u deteĭ.