The biological fate of sulphur colloid.
The in-vivo behaviour of sulphur colloid has been investigated using colloids labelled with 35S as well as 99m Tc. The rates of clearance of 35S and 99m Tc from the blood, the rates of accumulation in liver and bone and the distribution of the two radioisotopes in various organs are all markedly different. The results demonstrate that although technetium is rapidly removed from the blood stream and primarily accumulated in the liver the colloid particles themselves are broken down in vivo with the release of sulphur.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D003102:Colloids / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D013670:Sodium Pertechnetate Tc 99m; D013154:Spleen / Q000378:metabolism; D013462:Sulfur Radioisotopes / Q000378:metabolism*; D013667:Technetium / Q000378:metabolism
D003102:Colloids; D013462:Sulfur Radioisotopes; D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m