[Morphological studies of bone marrow neutrophilic and acidophilic granulocytes of white rate during stimulated leukopoiesis].
The neutrophils and eosinophils of rat bone marrow were studied after stimulating bone marrow with leucogen administered in therapeutic doses. The morphological examinations of these cells were carried out under electron microscope analysing the activity of myeloperoxidase. Disturbances were observed in the formation of primary and secondary granules in the neutrophils. This suggest a decrease of their functional efficiency. The formation of granules in the neutrophils was similar to normal. After 7 days of leucogen administration the stability between the number of granules with core and without it was disturbed in favour of the latter ones. After 14 days the proportions in the number of both types of granules reverted to the normal values.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D004804:Eosinophils / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D008854:Microscopy, Electron; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical; D013844:Thiazoles / Q000494:pharmacology; D053778:Thiazolidines
D013844:Thiazoles; D053778:Thiazolidines; C001176:Leyk; D009195:Peroxidase
Badania morfologiczne granulocytów obojetnochłonnych i kwasochłonnych szpiku szczura białego w warunkach stymulowanej leukopoezy.