title: Influence of catecholamines on gonadotropin secretion in goldfish, Carassius auratus.
abstract: Serum gonadotropin (GtH) concentrations in female goldfish were measured before and at various times after intraperitoneal injection of drugs altering catecholamine synthesis and neural activities. Reserpine, a depleter of neurotransmitter stores, elevated serum GtH levels compared to controls, suggesting the general involvement of neurotransmitters in altering GtH release. 6-Hydroxydopamine, a catecholaminergic neurotoxin, increased serum GtH concentration, suggesting that catecholaminergic neurons inhibit GtH release. Blocking of L-DOPA and dopamine synthesis by alpha-methyl-para-tyrosine and carbidopa, respectively, but not norepinephrine by diethyldithiocarbamate, raised serum GtH values above those of controls. Injections of an alpha-agonist, clonidine, also increased serum GtH concentrations. These results suggest the existence of an inhibitory dopaminergic and a stimulatory alpha-adrenergic influence on GtH release in goldfish.
mesh_terms: D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D002395:Catecholamines / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology; D003530:Cyprinidae / Q000097:blood*; D004050:Ditiocarb / Q000494:pharmacology; D005260:Female; D006054:Goldfish / Q000097:blood*; D006062:Gonadotropins / Q000097:blood*; D006892:Hydroxydopamines / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D010053:Ovary / Q000502:physiology; D016627:Oxidopamine
chemical_list: D002395:Catecholamines; D006062:Gonadotropins; D006892:Hydroxydopamines; D008781:Methyltyrosines; C022260:alpha-methyltyrosine methyl ester; D016627:Oxidopamine; D004050:Ditiocarb; D003000:Clonidine; D002230:Carbidopa