Sodium valproate enhances responses to GABA receptor activation only at high concentrations.
Sodium valproate (VPA) enhanced muscimol-induced depolarizations of rat cuneate afferent fibres, but only at millimolar concentrations. VPA (10 mM) also reduced the potency of picrotoxin as an antagonist of muscimol without affecting that of bicuculline. These findings are discussed in relation to the anticonvulsant properties and potency of VPA.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008526:Medulla Oblongata / Q000502:physiology*; D009118:Muscimol / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A; D014018:Tissue Distribution; D014635:Valproic Acid / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001640:Bicuculline; D009118:Muscimol; D010852:Picrotoxin; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D014635:Valproic Acid; D005680:gamma-Aminobutyric Acid