Effect of lymphocytosis-promoting factor from Bordetella pertussis on cerebellar cyclic GMP levels.
Dermonecrotic toxin (DNT), lipopolysaccharide (LPS), and lymphocytosis-promoting factor (LPF) were isolated from Bordetella pertussis and tested for neuroactivity. When injected intraperitoneally into rats, a dose of 0.13 mg of LPF per kg elevated the cyclic GMP level in cerebellum by approximately 70%, whereas DNT (0.5 mg/kg) and LPS (1.5 mg/kg) were without effect. This action of LPF on the central nervous system was dose dependent and did not require the administration of any additional agent, such as histamine.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000472:pathogenicity*; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006388:Hemagglutinins / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008222:Lymphokines / Q000494:pharmacology*; D008297:Male; D037342:Pertussis Toxin; D051381:Rats; D010566:Virulence Factors, Bordetella
D001427:Bacterial Toxins; D006388:Hemagglutinins; D007376:Interleukin-2; D008222:Lymphokines; D010566:Virulence Factors, Bordetella; D000242:Cyclic AMP; D037342:Pertussis Toxin