Action spectrum for the in vitro induction of simian virus 40 by ultraviolet radiation.
A line of simian virus 40-transformed hamster kidney cells was exposed to ultraviolet radiation at eleven different wavelengths in the region 238-302 nm. An action spectrum derived from the resulting exposure-response curves for the induction of simian virus 40 from these cells exhibits a broad peak in the region 260-270 nm suggesting DNA as the major chromophore for this response. This conclusion is consistent with results obtained by other investigators who have noted viral induction by a number of DNA-damaging agents.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral / Q000528:radiation effects; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D007668:Kidney; D013539:Simian virus 40 / Q000254:growth & development*; D014466:Ultraviolet Rays; D014775:Virus Activation / Q000528:radiation effects*