Cardiovascular changes in response to selective monoamine oxidase inhibition in the rat.
Chronic (21 days) treatment with the selective monoamine oxidase (MAO)-A inhibitor clorgyline, but not with the MAO-B inhibitor deprenyl in pithed rats leads to increased blood pressure responses to sympathetic stimulation and intravenous tyramine, and to elevated unstimulated heart rates. No significant changes are observed in plasma catecholamine responses to sympathetic stimulation, nor in beta-adrenoreceptor numbers in heart ventricles. These findings suggest that the hypotensive effects of MAO inhibitors result from central nervous system rather than peripheral nervous system alterations.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002319:Cardiovascular System / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood; D003010:Clorgyline / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000032:analysis; D013564:Sympathetic Nervous System / Q000502:physiology; D014439:Tyramine / Q000494:pharmacology
D002395:Catecholamines; D008996:Monoamine Oxidase Inhibitors; D011943:Receptors, Adrenergic, beta; D003010:Clorgyline; D014439:Tyramine