Distribution of 35S in mice after oral administration of alpha-dithioacetamidinium chloride. An autoradiographic investigation.
The distribution of 35S in mice has been investigated by whole-body autoradiography after oral administration of the 35S labelled S-75 (2,2'-Dithiobis(N-[(1-adamantyl)-methyl]-acetamidine)dihydrochloride). The substance was rapidly absorbed, and the highest concentration occurred in the liver and kidneys. During the highest radiation protective activity (after about 45 min) a substantial concentration was found in the red pulp of the spleen. This supports previous findings that S-75 has its most marked protective effect on the splenic haemopoiesis. Previously, it was shown that cysteamine is more evenly distributed in the body than S-75, which is in agreement with its more generalized protective effect than S-75.
D000081:Acetamides / Q000378:metabolism*; D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000378:metabolism*; D013462:Sulfur Radioisotopes / Q000378:metabolism*; D013853:Thioacetamide / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D014018:Tissue Distribution
D000081:Acetamides; D011837:Radiation-Protective Agents; D013462:Sulfur Radioisotopes; D013853:Thioacetamide; C017267:2,2-dithiobis(N-(1-adamantyl)methyl)acetamide; D000218:Adamantane