title: Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates.
abstract: Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole, based on [(3)H]hypoxanthine uptake and quantitative parasite counts. In contrast, there were no significant differences between these drugs in their activity against clinical isolates of Candida spp.
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D007654:Ketoconazole / Q000031:analogs & derivatives; D010879:Piperazines / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; C035996:deacylketoconazole; D007654:Ketoconazole