Modulation of nicotinic transmission by biogenic amines in bullfrog sympathetic ganglia.
Studies of transmission in isolated paravertebral sympathetic ganglia of the bullfrog and at the sciatic-sartarius muscle synapse in the frog yielded evidence that biogenic amines such as catecholamines or 5-hydroxytryptamine can modulate transmission in sympathetic ganglia and at the neuromyal junction. These two transmitter substances are able to modulate transmission by affecting the amount of ACh release from presynaptic terminals and also by affecting the sensitivity of nicotinic Ach receptors of the subsynaptic membrane. Information is presented as to how these compounds exert their modulatory effects on these synapses.
D000109:Acetylcholine / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D007473:Ion Channels / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D011892:Rana catesbeiana; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011978:Receptors, Nicotinic / Q000187:drug effects*; D012584:Sciatic Nerve / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D007473:Ion Channels; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D012701:Serotonin; D000109:Acetylcholine; D004837:Epinephrine