Cardiac and hepatic effects of pre- and postnatal exposure to polybrominated biphenyls in rats.
Body weight gain and hepatic concentrations of vitamin A were reduced in Sprague-Dawley rats by pre- and postnatal exposure to 100 ppm polybrominated biphenyls (PBBs). The ratio of liver weight to body weight, activity of hepatic delta-aminolevulinic acid (ALA) synthetase, and urinary excretion of uro- and coproporphyrins were increased by PBBs. Treatment with PBBs also increased the left atrial inotropic response to calcium. However, PBBs had no effect on development of the adrenergic neuronal transport system in heart, left atrial baselike peak tension, or inotropic response to ouabain. Thus PBBs retarded body weight gain and produced a variety of alterations in liver, but had little effect on cardiac contractile function.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001713:Biphenyl Compounds / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects*; D003306:Coproporphyrins / Q000652:urine; D005260:Female; D008099:Liver / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011075:Polybrominated Biphenyls / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D014578:Uroporphyrins / Q000652:urine; D014801:Vitamin A / Q000378:metabolism
D001713:Biphenyl Compounds; D003306:Coproporphyrins; D011075:Polybrominated Biphenyls; D014578:Uroporphyrins; D014801:Vitamin A; D000624:5-Aminolevulinate Synthetase