title: Flow cytometry of lung carcinoma: a comparison of DNA stemline and cell cycle distribution with histology.
abstract: Flow cytometry studies of the DNA distribution of 33 lung tumors were carried out. All of the carcinomas (32 cases) had aneuploid DNA modal values, ranging from 2.15c to 5.05c; in the single case of carcinoid studied, the tumor cells were diploid. DNA ploidy levels tended to be higher for epidermoid than adenocarcinoma; they were the same in lymph node metastases as in the primary tumor. Cell cycle distributions calculated from the tumor cell DNA values showed considerable variation, ranging from 9% to 58% for the S phase and from less than 1% to 29% for the G2M phase. Whether these variations have clinical significance is not known at this time.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D002276:Carcinoid Tumor / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D008175:Lung Neoplasms / Q000032:analysis / Q000473:pathology*; D008207:Lymphatic Metastasis; D008938:Mitosis; D011003:Ploidies
chemical_list: D004273:DNA, Neoplasm