Polymorphism of the Hinf I restriction site located 1 Kb 5' to the human beta-globin gene.
Mapping of the DNA from 14 Mediterranean subjects indicates a genetic variation in an Hinf I recognition site located 1 kilobase 5' to the beta-globin gene. This Hinf I site was found associated with eight beta-thalassemic genes and 11 normal beta genes, and hence is not specifically linked to beta-thalassemia.
D001483:Base Sequence; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes / Q000235:genetics*; D005809:Genes, Regulator; D005914:Globins / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D013789:Thalassemia / Q000235:genetics
D005914:Globins; D004262:DNA Restriction Enzymes