Orthostatic hypotension after delta 9-tetrahydrocannabinol marihuana inhalation.
3 male glaucoma subjects experienced orthostatic hypotension within 10 min after completing 2% delta 9-THC ranging from 57 to 233 ng/ml were found 5 min after smoking. Peripheral venodilation appeared responsible for the precipitous decrease in systolic blood pressure in all 3 subjects. These orthostatic episodes which clinically simulated the typical 'faint' were characterized by the absence of tachycardia and their relief by assuming a reclining position. The postural hypotension occurred despite differences in inhalation technique, level of delta (9)-THC present in plasma, previous marihuana experience of body habitus.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D013759:Dronabinol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
D013759:Dronabinol; C025351:delta(9)-tetrahydrocannabinolic acid