title: C2 deficiency vasculitis: complication of enterocolitis, cutaneous ulcers, and neuropsychiatric disorder.
abstract: A rare case of systemic vasculitis with second component of complement (C2) deficiency was documented in a patient who developed colonic ulcerations, jejunal edema and dilatation, cutaneous ulcers, peripheral neuropathy, and psychosis. Colonoscopy revealed typical features of ischemic colitis and radiological examination showed ischemic changes in the jejunum and ileum. Histopathological examination of the cutaneous biopsy revealed typical necrotizing vasculitis. It is very likely that multiorgan involvement, including ischemic changes of the intestine, developed secondary to vasculitis associated with C2 deficiency.
mesh_terms: D003175:Complement C2 / Q000172:deficiency*; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007583:Jejunum / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D011618:Psychotic Disorders / Q000150:complications*; D012883:Skin Ulcer / Q000150:complications* / Q000473:pathology; D014456:Ulcer / Q000150:complications / Q000175:diagnosis; D014657:Vasculitis / Q000150:complications* / Q000473:pathology
chemical_list: D003175:Complement C2