The effect of visual deprivation on beta-adrenergic receptors in the visual centres of the rat brain.
The levels of binding of [3H]dihydroalprenolol to beta-adrenergic receptors in the visual centres and frontal cortex from brains of control, dark-reared and monocularly deprived rats were compared. Receptor binding is changed in monocularly deprived rats in the lateral geniculate nuclei and superior colliculi of both sides. Scatchard analyses indicated that the changes in the [3H]dihydroalprenolol binding in the lateral geniculate nuclei were due to alterations in both receptor affinity and receptor number. No effect of dark-rearing could be detected.
D000375:Aging; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D004082:Dihydroalprenolol / Q000378:metabolism; D007700:Kinetics; D051381:Rats; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012160:Retina / Q000502:physiology; D012683:Sensory Deprivation; D014793:Visual Cortex / Q000502:physiology; D014796:Visual Perception
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol