Platinum concentrations in human glioblastoma multiforme following the use of cisplatin.
A 24-year-old female with glioblastoma multiforme was not given a nitrosourea because of interstitial lung disease. Cisplatin was administered monthly for five cycles until disease progression. A second debulking procedure was performed and tumor tissue assayed for the presence of platinum. Levels were measurable 7 weeks after the course of treatment.
D000328:Adult; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D002945:Cisplatin / Q000032:analysis* / Q000627:therapeutic use; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D011658:Pulmonary Fibrosis / Q000150:complications; D014018:Tissue Distribution
D002945:Cisplatin