Effect of steroid hormones on virus-induced diabetes mellitus.
Female ICR Swiss mice, generally resistant to the diabetogenic effects of the D variant of encephalomyocarditis virus, develop diabetes to the same extent as males if they are pretreated with testosterone. The data suggest that testosterone is one of the factors involved in the development of diabetes in certain strains of mice.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000209:etiology*; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000150:complications; D004970:Estrone / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D011374:Progesterone / Q000494:pharmacology; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D001786:Blood Glucose; D012739:Gonadal Steroid Hormones; D004970:Estrone; D013739:Testosterone; D011374:Progesterone; D003345:Corticosterone