Familial dermatoglyphic analysis in syndactyly type I.
A familial dermatoglyphic study of 25 syndactyly type I patients and 53 unaffected first-degree relatives showed a significant increase of complex fingertip patterns in the patients and in their relatives as well. An embryonic link between the formation of complex fingertip patterns and syndactyly type I is postulated. The study contributes new data on the hereditary transmission of syndactyly type I which cannot be used for individual genetic counseling. Calculation of the recurrence risk is difficult in view of the reduced penetrance of the gene.
D001530:Belgium; D003878:Dermatoglyphics; D005260:Female; D005385:Fingers / Q000033:anatomy & histology; D006225:Hand / Q000033:anatomy & histology / Q000196:embryology; D006801:Humans; D008297:Male; D010375:Pedigree; D012737:Sex Factors; D013576:Syndactyly / Q000145:classification / Q000196:embryology / Q000235:genetics*