Pivmecillinam plus pivampicillin in urinary tract infections. A double-blind comparison with pivmecillinam alone in hospitalized patients.
Forty hospitalized patients with mostly uncomplicated urinary tract infections received treatment for ten days with either pivmecillinam/pivampicillin of pivmecillinam alone. The bacteriological cure rate immediately after therapy was discontinued was 82% (18/22) in the combination group and 72% (13/18) in the pivmecillinam group. The causative organisms were Enterobacteriaceae in 89% of the cases. All but one were sensitive in vitro to mecillinam alone. No side-effects were recorded.
D000368:Aged; D000561:Amdinocillin Pivoxil / Q000008:administration & dosage*; D000667:Ampicillin / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010397:Penicillanic Acid / Q000008:administration & dosage*; D010917:Pivampicillin / Q000008:administration & dosage*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D010917:Pivampicillin; D000561:Amdinocillin Pivoxil; D000667:Ampicillin; D010397:Penicillanic Acid