title: Hypothalamic deafferentation in the rat appears to discriminate between the anterior lobe and intermediate lobe response to stress.
abstract: Anterolateral deafferentation of the mediobasal hypothalamus prevented the increase of the plasma corticosterone concentration induced by ether, histamine and electric footshock. Hypothalamus deafferentation also prevented the ether stress-induced increase of the plasma levels of ACTH and beta-endorphin immunoreactivity (ACTHi, beta-ENDi). Infusion of isoproterenol evoked an increase of the plasma levels of corticosterone, ACTHi, beta-ENDi and alpha-MSH immunoreactivity (alpha-MSHi) in sham-operated rats. In rats with a deafferented hypothalamus, the responses of plasma corticosterone and ACTHi to isoproterenol were blocked but the responses of plasma beta-ENDi and alpha-MSHi remained intact. We conclude that circulating beta-ENDi after exposure to ether is of anterior lobe origin while circulating beta-ENDi after infusion of isoproterenol is of intermediate lobe origin.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004597:Electroshock; D004723:Endorphins / Q000097:blood; D004986:Ether; D005260:Female; D006632:Histamine; D007031:Hypothalamus / Q000503:physiopathology*; D007032:Hypothalamus, Anterior / Q000503:physiopathology*; D007033:Hypothalamus, Middle / Q000503:physiopathology*; D007545:Isoproterenol / Q000494:pharmacology; D009074:Melanocyte-Stimulating Hormones / Q000097:blood; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D004986:Ether; D001615:beta-Endorphin; D006632:Histamine; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D007545:Isoproterenol; D003345:Corticosterone