Search for new antiamebic agents. I. Synthesis and bioassay of new Schiff bases of 1-phenyl-2-morpholinoethylidene-1-urea.
As potential agents against E. histolytica 19 new Schiff bases of 1-phenyl-2-morpholinoethylidene-1-urea were synthesized by the condensation of the parent compounds with various carbonyl compounds. Thirteen of them were tested against the axenic culture of E. histolytica at concentration 125 microgram/cm3 but no significant amoebicidal activity was observed.
D000563:Amebicides / Q000032:analysis / Q000138:chemical synthesis*; D004748:Entamoeba histolytica / Q000187:drug effects; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology
D000563:Amebicides; D009025:Morpholines; D012545:Schiff Bases