[Changes in the levels of 3',5'-cAMP and 3',5'-cGMP in brain and heart tissues after exposure to toxins of Buthus eupeus scorpion venom].
Toxins isolated from Buthus eupeus scorpion stimulated the generation of cAMP and cGMP in mouse cerebellar and forebrain slices, as well as in isolated guinea-pig heart. Pharmacological analysis of neurotropic and cardiotropic effects of toxins has ascertained the relationship between the increased level of cyclic nucleotides and catecholaminergic and cholinergic effects of toxins.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D000242:Cyclic AMP / Q000032:analysis*; D006152:Cyclic GMP / Q000032:analysis*; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D009206:Myocardium / Q000032:analysis*; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D012604:Scorpion Venoms / Q000032:analysis / Q000494:pharmacology*
D010455:Peptides; D012604:Scorpion Venoms; D000242:Cyclic AMP; D006152:Cyclic GMP
Izmenenie urovneĭ 3',5'-tsAMF i 3',5'-tsGMF v tkaniakh mozga i serdtsa pri deĭstvii toksinov iada skorpiona Buthus eupeus.