Systemic effects of NaHCO3 in experimental lactic acidosis in dogs.
Lactic acidosis is characterized by metabolic acidosis due to accumulation of H+ ions from lactic acid with blood lactate of at least 5 mM. The standard treatment is intravenous NaHCO3, with resultant mortality in excess of 50%. Despite the high mortality, the metabolic and systemic effects of NaHCO3 used in the treatment of lactic acidosis have not been extensively studied. The present experiments in diabetic dogs were designed to address these questions. Dogs with phenformin-induced lactic acidosis (blood lactate above 5 mM, arterial pH below 7.20) were treated with equimolar amounts of either NaCl or NaHCO3 or received no therapy. Intravenous NaHCO3 resulted in a decline of cardiac output and intracellular pH (pHi) of liver and erythrocytes, whereas treatment with NaCl did not. With NaHCO3 but not with NaCl infusion gut lactate production increased almost stoichiometrically, with no change in arterial pH or bicarbonate but with a doubling of lactate. Bicarbonate also resulted in a decrease of hepatic portal vein blood flow. The mean survival time and percent mortality were similar in NaCl- vs. NAHCO3(-) treated animals. Although both groups lived longer than did animals receiving no therapy, the differences were not significant. Thus, treatment of experimental lactic acidosis with either NaCl or NaHCO3 or with no therapy results in no change of blood pH and bicarbonate and in a similar mortality. In terms of systemic effects, however, NaHCO3 results in significant decrements of liver and erythrocyte pHi, hepatic portal vein blood flow, and cardiac output and in significant increments of gut lactate production, whereas NaCl does not. The data suggest that the rationale for therapy of lactic acidosis with NaHCO3 should probably be reevaluated.
D000138:Acidosis / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D000818:Animals; D001639:Bicarbonates / Q000097:blood / Q000627:therapeutic use*; D001794:Blood Pressure; D002302:Cardiac Output; D003921:Diabetes Mellitus, Experimental / Q000150:complications; D004285:Dogs; D007773:Lactates / Q000097:blood*; D012039:Regional Blood Flow; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000627:therapeutic use; D013152:Splanchnic Circulation; D013997:Time Factors
D001639:Bicarbonates; D007773:Lactates; D012965:Sodium Chloride; D017693:Sodium Bicarbonate