Permeability of the blood-brain barrier in the rat after local proton irradiation.
Rats were irradiated laterally through the brain with 200 MeV protons. The beam was of circular cross-section with a diameter of 5 or 7 mm. The doses were 50, 70, 100 and 150 Gy. After irradiation the rats were examined several times by use of injected 99Tcm-pertechnetate. The uptake of the substance increased to a maximum after 20 to 30 days and then decreased to a normal level. Differences in maximum uptake with respect to dose were significant only for the smaller beam diameter.
D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D006470:Hemorrhage; D009336:Necrosis; D010539:Permeability; D011522:Protons; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013670:Sodium Pertechnetate Tc 99m; D013667:Technetium / Q000378:metabolism; D013997:Time Factors
D011522:Protons; D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m