Increased concentration of glucocorticoid receptors in rabbit iris--ciliary body compared to rabbit liver.
Dexamethasone binding to both rabbit iris-ciliary body and rabbit liver glucocorticoid receptors was compared by means of a batch assay in which the binding components were adsorbed to hydroxylapatite. The results showed that homogenates of both the rabbit iris-ciliary body and the rabbit liver contained a single class of high-affinity receptors. Binding affinity was virtually identical for the two receptors. A comparison of total binding sites in homogenates of the iris-ciliary body and the liver revealed that the iris-ciliary body glucocorticoid receptor was present in nearly twice the concentration of the hepatic receptor.
D000327:Adsorption; D000818:Animals; D002924:Ciliary Body / Q000032:analysis*; D003907:Dexamethasone / Q000378:metabolism*; D017886:Durapatite; D006882:Hydroxyapatites; D007498:Iris / Q000032:analysis*; D008099:Liver / Q000032:analysis*; D008297:Male; D011817:Rabbits; D011965:Receptors, Glucocorticoid / Q000032:analysis*; D011987:Receptors, Steroid / Q000032:analysis*
D006882:Hydroxyapatites; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D003907:Dexamethasone; D017886:Durapatite