Peripheral neuropathy after concomitant dimethyl sulfoxide use and sulindac therapy.
The case is presented of a 63-year-old man with a long history of degenerative arthritis who took sulindac (Clinoril) 200 mg BID for 6 months with no untoward effects. Then, without physician knowledge, he began using 90% dimethyl sulfoxide (DMSO) topically to his upper and lower extremities. Shortly thereafter, he developed a profound mixed sensorimotor peripheral neuropathy. Serial electromyographic and nerve conducion studies performed at intervals of several months for 1 year suggested both segmental demyelination and axonal neuropathy. The patient experienced initial deterioration followed by gradual but incomplete recovery.
D001168:Arthritis / Q000188:drug therapy; D004121:Dimethyl Sulfoxide / Q000009:adverse effects* / Q000378:metabolism; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007192:Indenes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects; D010292:Paresthesia / Q000139:chemically induced; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D012869:Skin Absorption; D013467:Sulindac / Q000009:adverse effects*
D007192:Indenes; D013467:Sulindac; D004121:Dimethyl Sulfoxide