title: [99mTc-pyrophosphate scintigraphic indices at different times in acute myocardial infarct].
abstract: The incorporation rate of 99mTc-pyrophosphate into the myocardium was studied in 123 patients with acute myocardial infarction at different stages of the disease. The capacity of the damaged myocardium to accumulate the labelled pyrophosphate decreased with its healing. The accumulation character of the radiopharmacologic preparation also changed. The revealed phenomena are explained by the features of the 99mTc-pyrophosphate concentration mechanisms of the damaged areas of the myocardium. during the necrosis phase pyrophosphate is accumulated in the irreversibly damaged myocardial cells. The incorporation of 99mTc-pyrophosphate into the myocardium at the late stages of the disease are explained by both the presence of the necrotized cells in the myocardium and possible binding of the radiopharmacologic preparation to collagen.
mesh_terms: D011756:Diphosphates; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D009336:Necrosis; D011877:Radionuclide Imaging; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate; D013997:Time Factors
chemical_list: D011756:Diphosphates; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium
vernacular_title: Pokazateli stsintigrafii s 99mTc-pirofosfatom v raznye sroki ostrogo infarkta miokarda.