Epidural beta-endorphin in treatment of pain.
Epidural administration of 3 mg of synthetic beta-endorphin produced analgesia in 10 patients with intractable pain due to disseminated cancer. Mean onset of relief of pain was 24 +/- 3 minutes and the mean duration of analgesia was 19 +/- 3 hours. The onset of analgesia produced by the epidural injection of beta-endorphin was slower and the duration less than those observed after intrathecal injection.
D000328:Adult; D000368:Aged; D004723:Endorphins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004824:Epidural Space; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin