Congenital hypertrophic pyloric stenosis and associated anomalies in the genitourinary tract.
Genitourinary anomalies were looked for in patients with congenital hypertrophic pyloric stenosis. In a prospective series of 64 patients investigated by intravenous pyelography, 13 were abnormal (20.6%). In a retrospective series of 232 patients, 6 had anomalies of the upper urinary tract (2.7%). In this latter series the incidence of inguinal hernia (3.4%), undescended testes (3.0%), and hypospadias (0.9%) was determined. In another 10 patients urinary tract anomalies (5), urinary infection (2), and a significant family history (3) were found associated with congenital pyloric stenosis. As the incidence of these anomalies is greater than expected, which suggests an interrelationship, a hypothesis has been proposed linking genetic factors and the metabolism of gastrin with the etiology of congenital hypertrophic pyloric stenosis.
D005260:Female; D005755:Gastrins / Q000097:blood; D006552:Hernia, Inguinal / Q000150:complications; D006801:Humans; D006984:Hypertrophy; D007680:Kidney Neoplasms / Q000150:complications; D008297:Male; D011446:Prospective Studies; D011707:Pyloric Stenosis / Q000097:blood / Q000150:complications / Q000151:congenital* / Q000473:pathology; D012189:Retrospective Studies; D014564:Urogenital Abnormalities; D009396:Wilms Tumor / Q000150:complications
D005755:Gastrins