Human papilloma virus 5-DNA in a carcinoma of an epidermodysplasia verruciformis patient infected with various human papillomavirus types.
An epidermodysplasia verruciformis patient suffering from generalized warts and a carcinoma at the forehead was found to be infected by at least six types and subtypes of human papillomaviruses. The central part of the carcinoma, however, harbored only human papillomavirus 5 DNA. The DNA persisted extrachromosomally in high genome copy number. In contrast to wart DNA preparations, a significant part of the viral sequences in the carcinoma was present as oligomers, at least part of them being concatemers as shown by S1 digest. The human papillomavirus 5 subtype from this carcinoma was compared with the two other carcinoma isolates described so far and proved to be rather similar.
D000328:Adult; D000818:Animals; D001913:Bowen's Disease / Q000235:genetics; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D008297:Male; D008970:Molecular Weight; D027383:Papillomaviridae / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics / Q000382:microbiology*; D014412:Tumor Virus Infections / Q000150:complications / Q000235:genetics / Q000382:microbiology*; D014860:Warts / Q000150:complications* / Q000235:genetics
D004279:DNA, Viral