title: Acute sodium fluoride toxicity in the rat kidney.
abstract: Acute sodium fluoride toxicity was studied histologically and histochemically in the rat kidney. The doses given subcutaneously by a single injection were 10, 12.5 and 15 mg/100 gm of body weight and the duration after the administration were 30 minutes, and one, 3, 5 and 7 days. Histologically, coagulation necrosis of the proximal tubules was found at 1 day and the injury was most striking at 3 days. Regeneration was almost complete at 7 days. Among the enzymes studied, e.g., alkaline phosphatase, acid phosphatase, 5'-nucleotidase, adenosine triphosphatase and succinic dehydrogenase, and acid phosphatase of the tubular epithelium was the most severely impaired.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000251:Adenosine Triphosphatases / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D005459:Fluorides / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology / Q000502:physiology; D008297:Male; D009708:Nucleotidases / Q000032:analysis; D051381:Rats; D012038:Regeneration / Q000187:drug effects; D012969:Sodium Fluoride / Q000633:toxicity*; D013385:Succinate Dehydrogenase / Q000032:analysis
chemical_list: D012969:Sodium Fluoride; D013385:Succinate Dehydrogenase; D009708:Nucleotidases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases; D005459:Fluorides