title: A fixed combination of pivmecillinam and pivampicillin in complicated urinary tract infections. A double-blind comparison with pivmecillinam.
abstract: 23 urological patients, primarily with underlying disease of the urinary tract, received a 10-day treatment with either pivmecillinam/pivampicillin or pivmecillinam alone. Combination therapy eradicated urinary pathogens in the urine at a 48 h control in 11/11 patients treated with the combination compared with 6/12 patients receiving pivmecillinam alone (p less than 0.05). Two of the treatment failures on pivmecillinam alone were caused by Enterobacteriaceae that were in vitro sensitive to mecillinam. A repeated course with the combination was successful in both of these patients. Apart from a rash seen in one patient in the combination group, no side effects were recorded.
mesh_terms: D000328:Adult; D000368:Aged; D000561:Amdinocillin Pivoxil / Q000008:administration & dosage* / Q000627:therapeutic use; D000667:Ampicillin / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010397:Penicillanic Acid / Q000008:administration & dosage*; D010917:Pivampicillin / Q000008:administration & dosage* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D010917:Pivampicillin; D000561:Amdinocillin Pivoxil; D000667:Ampicillin; D010397:Penicillanic Acid