An Asp-Asn substitution in the proteolipid subunit of the ATP-synthase from Escherichia coli leads to a non-functional proton channel.
D025181:ATP Synthetase Complexes; D000595:Amino Acid Sequence; D001216:Asparagine / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D007473:Ion Channels / Q000378:metabolism*; D046911:Macromolecular Substances; D009097:Multienzyme Complexes / Q000378:metabolism*; D009154:Mutation; D010770:Phosphotransferases / Q000378:metabolism*; D011522:Protons; D013329:Structure-Activity Relationship
D007473:Ion Channels; D046911:Macromolecular Substances; D009097:Multienzyme Complexes; D011522:Protons; D001224:Aspartic Acid; D001216:Asparagine; D010770:Phosphotransferases; D025181:ATP Synthetase Complexes