Nonrespiratory metabolic function and morphology of lung following exposure to polybrominated biphenyls in rats.
Exposure to polybrominated biphenyls (PBBs) resulted in increased activity of microsomal arylhydrocarbon hydroxylase and ethoxyresorufin-O-deethylase in rat lung. Clearance of 5-hydroxytryptamine (5-HT) and angiotensin 1 by perfused lungs was decreased by PBBs. However, PBBs had no effect on the activity of epoxide hydrolase, monoamine oxidase, or angiotensin-converting enzyme in lung. The only histopathologic change detected in lungs from PBB-treated rats was an increase in alveolar type II cell lamellar bodies. Selective accumulation of certain PBB congeners by lung was not observed in this investigation.
D000818:Animals; D000831:Animals, Newborn; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D001713:Biphenyl Compounds / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004851:Epoxide Hydrolases / Q000378:metabolism; D005260:Female; D008168:Lung / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D011075:Polybrominated Biphenyls / Q000378:metabolism / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D001713:Biphenyl Compounds; D011075:Polybrominated Biphenyls; D001189:Aryl Hydrocarbon Hydroxylases; D008995:Monoamine Oxidase; D004851:Epoxide Hydrolases; D007703:Peptidyl-Dipeptidase A