Adrenocorticotropin, and corticosterone secretion in Brattleboro rats.
Brattleboro rats which lack endogenous vasopressin have been used to study the role of vasopressin as a corticotropin-releasing factor. Plasma ACTH, beta-endorphin, and corticosterone were measured by RIA in male and female Long-Evans and Brattleboro rats under the following conditions: unstressed, after ether stress, after nicotine injection, and after adrenalectomy. A significant reduction in the ACTH, beta-endorphin, and corticosterone responses to the different experimental procedures was observed in the Brattleboro rats. However, in this strain of rats, a significant increase in the release of all three hormones was obtained, suggesting that vasopressin has only a synergistic role in the regulation of their secretion.
D000311:Adrenal Glands / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004723:Endorphins / Q000097:blood*; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D009538:Nicotine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012737:Sex Factors; D013312:Stress, Physiological / Q000378:metabolism; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin; D009538:Nicotine; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone