Neuromuscular transmission in the corpus-fundus of the urinary bladder. An in vitro study in the cat.
In muscle strips from the corpus-fundus of the cat bladder the intramural nervous system was activated by field stimulation. The resulting muscle contraction could not be inhibited by atropine, phentolamine or quinidine. These drugs enhanced the response. Tetrodotoxin, methysergide, cyproheptadine and indomethacin blocked the field-stimulation response in a dose dependent manner. The interpretation of these results with references to transmission at the neuromuscular junction of the bladder is discussed.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction; D010646:Phentolamine / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation* / Q000502:physiology
D011453:Prostaglandins; D012702:Serotonin Antagonists; D012701:Serotonin; D001285:Atropine; D007213:Indomethacin; D010646:Phentolamine