title: Effect of lead acetate on superoxide anion generation and its scavengers in mice given endotoxin.
abstract: The administration of endotoxin to mice rendered hypersensitive by lead acetate resulted in profound lipid peroxide formation in the liver 6 hr postintoxication. Endotoxin plus lead acetate administration depressed glutathione peroxidase and superoxide dismutase activities in mouse liver, whereas superoxide anion generation significantly increased in the livers of endotoxin plus lead acetate-treated mice compared with that in mice treated with endotoxin alone. Serum acid phosphatase and lactate dehydrogenase isozyme exhibited much more leakage in endotoxin plus lead acetate-injected mice than in sera of mice given endotoxin alone. Nonprotein SH level in the liver was reduced markedly in endotoxin-lead treated mice compared with those receiving endotoxin alone. The plasma vitamin E level was found to decline by 6 hr postintoxication in both endotoxin-lead and endotoxin alone-treated mice, and the transient elevation of the plasma level at 18 hr may be considered to indicate mobilization from other tissues into the blood.
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007854:Lead / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D009942:Organometallic Compounds; D010100:Oxygen / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D014810:Vitamin E / Q000097:blood
chemical_list: D004731:Endotoxins; D007527:Isoenzymes; D008054:Lipid Peroxides; D009942:Organometallic Compounds; D013481:Superoxides; D014810:Vitamin E; D007854:Lead; D007770:L-Lactate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000135:Acid Phosphatase; C008261:lead acetate; D010100:Oxygen