Alterations in protein and glycoprotein composition of rat embryo fibroblasts transformed by herpes simplex virus type 2.
Total and superficially exposed plasma membrane components of tumorigenic herpes-simplex-virus (HSV)-transformed fibroblasts were studied. As a result of oncogenic HSV transformation, a significant decrease of polypeptides 230,000, 180,000, 56,000 and 43,000 daltons was found. These changes were accompanied by a significant increase in superficial exposition of several sialopeptides and two peptides of 30,000 and 15,000 daltons. It was suggested that these two peptides may represent virus-coded components of HSV-transformed fibroblasts. The present results indicate that the HSV-transformed tumorigenic cell clone meets all previously described criteria for oncogenically transformed cells.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000032:analysis*; D002471:Cell Transformation, Neoplastic; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis*; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D018139:Simplexvirus
D006023:Glycoproteins; D010455:Peptides