Effect of propranolol and phenoxybenzamine on muscle strength and physical endurance, and on exercise-induced changes in muscle glycogen and blood lactic acid levels in rats.
Propranolol and phenoxybenzamine (PBZ) had no major effect on swimming-endurance performance and skeletal muscle pulling-strength in rats. Propranolol, like exercise itself diminished the resting skeletal muscle glycogen (SMG) content, but the drug did not lower the resting blood lactic acid (BLA) levels. Propranolol significantly antagonised the 25-min exercise-induced BLA elevation, indicating that lactacidaemia is possibly a beta-receptor response. However, propranolol did not exhibit an overall beneficial effect on swimming endurance. PBZ had a negligible effect on maximal swimming time (MST) and had no major effects on the SMG content and BLA levels.
D000818:Animals; D005260:Female; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D010643:Phenoxybenzamine / Q000494:pharmacology*; D010807:Physical Endurance / Q000187:drug effects; D005082:Physical Exertion; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects
D007773:Lactates; D011943:Receptors, Adrenergic, beta; D010643:Phenoxybenzamine; D019344:Lactic Acid; D006003:Glycogen; D011433:Propranolol