Effect of acyclovir on latent herpes simplex virus infections in trigeminal ganglia of mice.
The inhibition by acyclovir of the in vitro reactivation of herpes simplex virus from latently infected ganglion explant cultures is dependent on the continuous presence of this drug. Administration of acyclovir subcutaneously, orally, or by continuous perfusion to mice with established latent infections did not eliminate latent virus from the trigeminal ganglia.
D000212:Acyclovir; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D046508:Culture Techniques; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006561:Herpes Simplex / Q000188:drug therapy; D051379:Mice; D008812:Mice, Hairless; D010746:Phosphonoacetic Acid / Q000627:therapeutic use; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014276:Trigeminal Nerve / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D006147:Guanine; D010746:Phosphonoacetic Acid; D000212:Acyclovir