Ammonium chloride prevents lytic growth of reovirus and helps to establish persistent infection in mouse L cells.
Ammonium chloride, a lysosomotropic agent that raises intralysosomal pH, reduces the yield of reovirus during infection of mouse L cells. Subsequent removal of ammonium chloride results in the rapid establishment of a persistent infection.
D000643:Ammonium Chloride / Q000494:pharmacology*; D000818:Animals; D006863:Hydrogen-Ion Concentration; D007739:L Cells; D008247:Lysosomes / Q000502:physiology; D051379:Mice; D012087:Reoviridae / Q000254:growth & development*; D012088:Reoviridae Infections / Q000209:etiology*; D014779:Virus Replication / Q000187:drug effects*
D000643:Ammonium Chloride