Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas.
Proviruses of avian leukosis virus (ALV) are located in the vicinity of a putative cellular oncogene (c-myc) in ALV-induced bursal lymphomas. Enhanced expression of c-myc occurs in association with proviruses found in any of three configurations: (I) on the 5' side ('upstream') of c-myc in the same transcriptional orientation; (II) on the 3' side ('downstream') of c-myc in the same orientation; (III) upstream, in the transcriptional orientation opposite to that of c-myc. Thus, activation of adjacent cellular genes by retroviral DNA can involve mechanisms other than provision of a transcriptional promoter.
D000818:Animals; D001353:Avian Leukosis / Q000382:microbiology*; D001354:Avian Leukosis Virus / Q000235:genetics; D001483:Base Sequence; D002645:Chickens; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics*; D005814:Genes, Viral; D009153:Mutagens; D014158:Transcription, Genetic
D004279:DNA, Viral; D009153:Mutagens; D004262:DNA Restriction Enzymes