(+)-Cyanidanol-3 changes functional properties of collagen.
About 6-7 (+)-cyanidanol-3 molecules are bound per collagen alpha-chain. The (+)-cyanidanol-3 treated collagen contains an increased number of pepsin-resistant cross-links, is less susceptible to attack by mammalian collagenase, has a higher shrinkage temp and forms unstructured aggregates. Cell and organ culture studies show that these biological systems produce less protein and collagen in the presence of (+)-cyanidanol-3 and that the newly synthesized collagen is less soluble.
D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003094:Collagen / Q000378:metabolism*; D004355:Drug Stability; D005347:Fibroblasts / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D007231:Infant, Newborn; D003012:Microbial Collagenase / Q000494:pharmacology; D009924:Organ Culture Techniques; D010434:Pepsin A / Q000494:pharmacology
D001578:Benzopyrans; D002392:Catechin; D003094:Collagen; D010434:Pepsin A; D003012:Microbial Collagenase