Induction of 2H+/Me2+ exchange in rat-liver mitochondria.
The time dependency of CA2+ efflux from Ca2+-loaded rat liver mitochondria has been investigated. The rate of ruthenium-red-insensitive Ca2+ efflux is continuously increased during the retention as a result of induction of an electroneutral H+ Ca2+ exchange system. The activation of the Ca2+ efflux pathway takes place under the constant value of the membrane potential and is accompanied by oxidation of mitochondrial pyridine nucleotides. It has also been found that the ruthenium-red-insensitive H+/Sr2+ exchange occurs in mitochondria during Sr2+-induced oscillation of ion fluxes. The rate of H+/Sr2+ exchange is variable and depends on the stage of the oscillatory cycle.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism; D066298:In Vitro Techniques; D007473:Ion Channels; D008564:Membrane Potentials; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013324:Strontium / Q000378:metabolism
D007473:Ion Channels; D006859:Hydrogen; D002118:Calcium; D013324:Strontium