Effect of beta-endorphin on the thermal excitability of preoptic neurons in the unanesthetized rabbit.
The opioid peptide, beta-endorphin (beta-E), will promote changes in body temperature when injected into the brain. It is possible that beta-E alters body temperature by affecting the activity of thermoregulatory neurons in the preoptic anterior hypothalamus (POAH). Single unit activity in the POAH was recorded in unanesthetized rabbits while radiant heat was applied to the dorsal skin. Beta-E was then microinjected into the POAH, and the peripheral heating was repeated. Seventy-seven percent of the POAH neurons were responsive to skin heating. Beta-E and equal excitatory and inhibitory effects on warm-excited and warm-inhibited neurons. Four of six warm-excited neurons were converted to warm-inhibited or unresponsive following beta-E injection. Six out of ten warm-inhibited neurons were converted to warm-excited or unresponsive by beta-E. Beta-E-induced shifts in thermal excitability of POAH neurons may be responsible for the ability of POAH injections of beta-E to elevate body temperature in the rabbit.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004594:Electrophysiology; D004723:Endorphins / Q000494:pharmacology*; D006358:Hot Temperature; D007031:Hypothalamus / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D012867:Skin; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin