Protective effects of WR-2721 against radiation-induced injury of murine gut, testis, lung, and lung tumor nodules.
WR-2721 (S-2-(3 aminopropylamino) ethylphosphorothioic acid) has been investigated for its ability to protect gut, lung, and testis, as well as fibrosarcoma (FSa) tumor nodules, in the lungs of mice from gamma-radiation injury. This compound greatly protected jejunum and testis epithelial cells. FSa micrometastases in the lung were protected to a lesser extent than jejunum and testis. Conversely, WR-2721 was not able to protect the lung against radiation-induced enhancement of tumor metastases formation generated by intravenously injected FSa cells.
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D004064:Digestive System / Q000166:cytology / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009362:Neoplasm Metastasis; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents; D013737:Testis / Q000528:radiation effects
D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D004999:Amifostine