title: Conserved linkage of soluble aconitase and galactose-1-phosphate uridyl transferase in mouse and man: assignment of these genes to mouse chromosome 4.
abstract: Polymorphism and linkage of mouse soluble aconitase (Aco-1) and galactose-1-phosphate uridyl transferase (Galt) are reported. Three alleles at each locus were recognized on the basis of differences in electrophoretic mobility. Linkage crosses involving Aco-1, brown (b), major urinary protein (Mup-1), and the Rb(4.6)2Bnr Robertsonian translocation (Rb2) showed that Aco-1 is located on the proximal portion of chromosome 4 between (Mup-1) and the centromere. Because Aco-1 and Galt are located on the short arm of the human 9, linkage of mouse Aco-1 and Galt was thought to be likely. Linkage crosses involving Rb2, Galt, Aco-1, Mup-1, and b confirmed this expectation and established the order of loci as: centromere--Galt--Aco-1--Mup-1--b. The conserved linkage of Aco-1 and Galt in mouse and man probably represents an ancient linkage not yet disrupted by chromosomal rearrangement, rather than a linkage preserved by natural selection.
mesh_terms: D000154:Aconitate Hydratase / Q000235:genetics*; D000483:Alleles; D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains; D009713:Nucleotidyltransferases / Q000235:genetics*; D011110:Polymorphism, Genetic; D013045:Species Specificity; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase / Q000235:genetics*
chemical_list: D007527:Isoenzymes; D009713:Nucleotidyltransferases; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase; D000154:Aconitate Hydratase