title: Radiation inactivation of (Na+ + K+)-ATPase. A small target size for the K+-occluding mechanism.
abstract: Radiation inactivation of partially purified (Na+ + K+)-ATPase (ATP phosphohydrolase, EC 3.6.1.3) from pig kidney outer medulla shows that the target size for Rb+ occlusion by the enzyme (in the absence of phosphorylation) is much smaller than the target size for p-nitrophenyl phosphatase activity, which is itself smaller than the reported target size for (Na+ + K+)-ATPase activity.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D007679:Kidney Medulla / Q000201:enzymology*; D007700:Kinetics; D008970:Molecular Weight; D011487:Protein Conformation; D012413:Rubidium / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000528:radiation effects*; D013552:Swine
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase; D012413:Rubidium