3H-Diazepam binding sites in Roman high- and low-avoidance rats.
The binding of 3H-diazepam to membrane benzodiazepine receptors was examined in 2 psychogenetically selected lines of rats, which differ according to the selection criterion in avoidance behaviour (RHA/Verh greater than RLA/Verh) and, in addition, in emotionality (RHA/Verh less than RLA/Verh). RHA/Verh rats tended to show higher specific diazepam binding in all CNS-subregions when compared with RLA/Verh animals. Significant differences were found in the cortex, striatum, hippocampus, thalamic region and pons-medulla. These results reinforce the contention that a system involving benzodiazepine receptors may play a role in emotional behaviour.
D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000378:metabolism*; D011963:Receptors, GABA-A; D014316:Tritium
D011955:Receptors, Drug; D011963:Receptors, GABA-A; D014316:Tritium; D003975:Diazepam