Dose response experiments using the mouse tail model.
Radiation induced tail necrosis in BALB/c mice was used to investigate the effects of tissue temperature and local oxygenation on the radiation response. Single doses of 250 kV roentgen-rays were given over the temperature range 32.5 to 37 degrees C and dose response curves obtained. The temperature dependence of the response was shown to be consistent with changing hypoxic status by the derivation of a simple model; this has practical implications for the treatment of patients using simultaneously combined radiation therapy and hyperthermia.
D000818:Animals; D001831:Body Temperature; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D006358:Hot Temperature / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D010100:Oxygen; D011336:Probability; D011878:Radiotherapy / Q000379:methods*; D013623:Tail / Q000473:pathology / Q000528:radiation effects
D010100:Oxygen