The effects of the pyrethroids deltamethrin and cismethrin on nerve excitability in rats.
Deltamethrin produced a prolonged period of increased excitability following the passage of a nerve impulse, which was dose-related and lasted up to 400 ms. Excitability changes were detected without neurological signs following a single IV injection of 0.5 mg/kg and feeding 200,100 and 50 ppm in the diet for up to 8 weeks. No changes were detected following 0.3 mg/kg IV or 25 ppm in the diet. No cumulative effects were detected during chronic feeding. Cismethrin produced increased nerve excitability only between 2 and 4 ms after a nerve impulse. Excitability changes after cismethrin were biphasic during the first 20 ms.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*
D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; C017498:cismethrin