title: [Genome instability and neoplasia].
abstract: Necessity of oncogene for the neoplastic cell transformation is substantiated. The oncogene may be introduced into the cell by a virus; be present in the cell from its formation but be repressed by products of regulatory genes; be arisen from separated DNA segments. The latter possibility is discussed in view of data on the presence of mobile elements and Sarc sequences in the cell genome.
mesh_terms: D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure; D004251:DNA Transposable Elements; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005796:Genes; D005809:Genes, Regulator; D008970:Molecular Weight; D009154:Mutation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000235:genetics*; D009858:Oncogenic Viruses / Q000235:genetics / Q000472:pathogenicity; D012367:RNA, Viral / Q000235:genetics; D014162:Transfection; D014170:Transformation, Genetic; D014775:Virus Activation
chemical_list: D002273:Carcinogens; D004251:DNA Transposable Elements; D004273:DNA, Neoplasm; D004279:DNA, Viral; D012367:RNA, Viral
vernacular_title: Nestabil'nost' genoma i neoplaziia.