title: Combined high-performance liquid chromatography and radioimmunoassay method for the analysis of delta 9- tetrahydrocannabinol and its metabolites in plasma and urine.
abstract: A high-performance liquid chromatography-radioimmunoassay method for the measurement of cannabinoids in plasma and urine is described. The experimental procedure consists of chromatographing a plasma extract or hydrolysed urine sample by high-performance liquid chromatography and quantifying the eluting cross-reacting cannabinoids with radioimmunoassay. The concentrations of delta 9- tetrahydrocannabinol (THC), cannabinol, mono-hydroxylated metabolites, di-hydroxylated metabolites, delta 9-THC-11-oic acid, and delta 9-THC-11-oic acid ester glucuronide may be measured by this technique.
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003429:Cross Reactions; D013759:Dronabinol / Q000032:analysis* / Q000097:blood / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D011863:Radioimmunoassay / Q000379:methods
chemical_list: D013759:Dronabinol