Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGE-1) and 2 (IGF-2) and insulin throughout the adult human brain.
The present study examines adult human brain tissue for the presence of receptors for insulin-like growth factors (IGFs) 1 and 2 and insulin. Binding sites for all hormones were widely distributed throughout the brain removed at autopsy, with the highest specific binding being found in the various cortical regions. Cross-reaction studies performed on frontal lobe biopsy material indicated specific binding sites for IGF-1 and insulin whereas iodinated IGF-2 was equally displaced by IGF-1 and IGF-2, suggesting the presence of an additional IGF-2-like binding site in the adult brain.
D000368:Aged; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017451:Receptors, Somatomedin; D013002:Somatomedins / Q000378:metabolism*
D007328:Insulin; D010455:Peptides; D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D013002:Somatomedins; D011972:Receptor, Insulin