HLA antigens in adults negative for antibody to Epstein-Barr virus (EBV).
Evidence for a genetic component in susceptibility to Epstein-Barr virus (EBV) infection was sought by comparing HLA A and B phenotypes of EBV antibody-negative Scottish medical students and randomly chosen antibody-positive controls. No statistically significant differences were observed, but three antigens, (A10, A29 and B15), were relatively underrepresented in the EBV seronegative group; findings which agree with data previously reported from a similar study in Los Angeles. A strong association between the HLA A1/Blank phenotype and EBV seronegativity, evident in the Los Angeles population, was not confirmed in the present study.
D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D010641:Phenotype; D013337:Students, Medical; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology
D000914:Antibodies, Viral; D006680:HLA Antigens