Effect of glutaurine and its derivatives and their combinations with radiation protective substances upon irradiated mice.
The radiation protective effects of glutaurine (gamma-L-glutamyl-taurine, Litoralon), and of some of its derivatives, as well as of their combinations with substances of the amino-alkyl-thiol group, have been investigated in mice. The results suggest that glutaurine possesses a radiation protective effect in animals irradiated with LD50/30 of roentgen rays and 60Co gamma rays. The compound has a favourable effect also when administered after irradiation. Its protective effect is especially marked in case of prolonged irradiation. Among the combinations best results were obtained by its simultaneous administration with subminimal doses of AET or cystamine. Some of its derivatives also exhibited considerable protection against irradiation with roentgen rays.
D000818:Animals; D003538:Cystamine / Q000494:pharmacology; D005973:Glutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010281:Parathyroid Hormone / Q000494:pharmacology*; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology
D010281:Parathyroid Hormone; D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds; D005973:Glutamine; D013654:Taurine; C020903:glutaurine; D003538:Cystamine