High levels of intracellular bombesin characterize human small-cell lung carcinoma.
"Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.
D000230:Adenocarcinoma / Q000032:analysis; D001839:Bombesin / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000032:analysis; D002460:Cell Line; D006801:Humans; D008175:Lung Neoplasms / Q000032:analysis*; D008654:Mesothelioma / Q000032:analysis; D010455:Peptides / Q000032:analysis*
D010455:Peptides; D001839:Bombesin