Nonspecific excitatory effects of morphine: reverse-order precipitated withdrawal and dose-dose interactions.
We recently reported that, in naive mice pretreated with naloxone, morphine can cause withdrawal-like signs that seemingly are not mediated by "opiate" receptors. Such results were confirmed and extended here with another mouse strain. Repetitive vertical jumping could occur respective of injection sequence and depended on dose and dose ratio of the two drugs.
D017109:Akathisia, Drug-Induced; D000818:Animals; D004347:Drug Interactions; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D009270:Naloxone / Q000008:administration & dosage; D011957:Receptors, Opioid / Q000187:drug effects; D013375:Substance Withdrawal Syndrome; D013997:Time Factors
D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine