title: Alteration of sodium and potassium mobilization and of adrenal function by long-term ingestion of lead.
abstract: Serum sodium concentration was markedly decreased by long-term (12 weeks) ingestion of lead above 5 mg Pb . kg-1 . day-1, whereas serum potassium concentration was notably decreased by the long-term (12 weeks) ingestion of lead above 2 mg Pb . kg-1. Urinary sodium and potassium in fasted rats were increased markedly 24 hr after a single lead dose (200 mg Pb/kg, o.p.) [Y. Suketa, S. Hasegawa and T. Yamamoto, Toxic. appl. Pharmac. 47, 203 (1979)]. In contrast, urinary excretion of sodium or potassium in non-fasted rats was not changed significantly by 2 weeks of lead ingestion at 200 mg Pb . kg-1 . day-1. Renal activities of Na+, K+-ATPase and K+-dependent phosphatase were decreased to 50-70% of control values by long-term (12 weeks) ingestion of lead (above 5 mg Pb . kg-1 . day-1).
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects*; D000450:Aldosterone / Q000097:blood; D000818:Animals; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D007855:Lead Poisoning / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008861:Microsomes / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D000450:Aldosterone; D012964:Sodium; D010744:Phosphoric Monoester Hydrolases; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium