title: [Anaplastic carcinoma of the thyroid: early clinical and histopathological stages. Therapeutic implications (author's transl)].
abstract: Anaplastic carcinoma of the thyroid is generally considered a primary condition. Our study, based on ten observations, shows that anaplastic carcinoma of the thyroid with a rapidly fatal course may arise in long-standing goiters. Borderline histologic changes may be encountered; in some differentiated nodules, undifferentiated areas were found. Factors inducing transformation is equally obscure. Anaplastic changes may result from the growth of previously quiescent clones. The time-interval between benignant and malignant lesions varies widely and is difficult to establish unequivocally. In some instances, anaplastic carcinoma occurs after surgical removal of differentiated carcinoma.
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013959:Thyroid Diseases / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013997:Time Factors
vernacular_title: Carcinome thyroïdien anaplasique. Stades cliniques histopathologiques préalables. Implications thérapeutiques.