Pyrazole and 4-methylpyrazole inhibit oxidation of ethanol and dimethyl sulfoxide by hydroxyl radicals generated from ascorbate, xanthine oxidase, and rat liver microsomes.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D004121:Dimethyl Sulfoxide / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D000077604:Fomepizole; D005609:Free Radicals; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014969:Xanthine Oxidase / Q000378:metabolism*
D005609:Free Radicals; D006878:Hydroxides; D011720:Pyrazoles; D017665:Hydroxyl Radical; D000431:Ethanol; C031280:pyrazole; D000077604:Fomepizole; D014969:Xanthine Oxidase; D001205:Ascorbic Acid; D004121:Dimethyl Sulfoxide