title: [Clinical experience with cefotiam (author's transl)].
abstract: Cefotiam (CTM) were clinically applied to 6 cases and the following results were obtained: 1. The patients were aged 1 year in 5 cases and 7 years in 1 case. They comprised three cases of acute tonsillitis and 1 case each of phlegmon, bronchopneumonia and cervical abscess. CTM was administered in a daily dose of 50-115 mg/kg t.i.d. by an 1-hour intravenous drip infusion for 4 to 8 days. 2. The causative bacteria were S. aureus in 3 cases and H. parainfluenzae, K. pneumoniae and unknown pathogen in each 1 case. The organisms were eradicated in all cases except for only 1 case of S. aureus. 3. Overall responses were good in 4 cases and fair in 2 cases. 4. As for the abnormal laboratory findings, slight increase of GOT and GPT was observed in 1 case. Any other side effects were not observed.
mesh_terms: D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002439:Cefotaxime / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015310:Cefotiam; D002648:Child; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D015310:Cefotiam; D002439:Cefotaxime