Inhibitory mechanisms of insulin secretion associated with hypothermic open-heart surgery.
In order to clarify the inhibitory mechanism of insulin secretion associated with open-heart surgery, the influence of insulin antagonistic hormones on insulin secretion was studied in 20 patients with congenital heart diseases undergoing open-heart surgery, under simple deep hypothermia. Despite a hyperglycemia, plasma immunoreactive insulin and C-peptide showed no change during the cooling period, while with the exception of plasma human growth hormone, dopamine-beta-hydroxylase, immunoreactive glucagon, cortisol and cyclic AMP in plasma, either showed no change, or a decrease during the cooling period. It is assumed that catecholamine, glucocorticoid and glucagon do not play an important role in the inhibitory mechanism of insulin secretion during hypothermic open-heart surgery, and a transient hypofunction of the pancreas as well as the liver and the adrenal gland is probably involved.
D001786:Blood Glucose / Q000032:analysis; D006348:Cardiac Surgical Procedures; D002395:Catecholamines / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D000242:Cyclic AMP / Q000097:blood; D005934:Glucagon / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007036:Hypothermia, Induced; D007223:Infant; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion
D001786:Blood Glucose; D002395:Catecholamines; D007328:Insulin; D013006:Growth Hormone; D005934:Glucagon; D000242:Cyclic AMP; D006854:Hydrocortisone