title: [Treatment of severe diabetic ketoacidosis in children. A comparative study of two methods (author's transl)].
abstract: Fifteen children with severe diabetic ketoacidosis (pH less than 7,10) were treated according to two protocols. Protocol I used in 7 patients, consisted in a low dose insulin therapy by intravenous and intramuscular injections. Protocol II consisted in a low dose continuous intravenous insulin therapy, with insulin added to the rehydration solution at constant concentration (22 U/l). Rehydration and potassium supplementation were similar in both methods. The fall of glucose concentration, rise in venous pH, fall of diuresis, glycosuria, ketonuria were similar in the two groups. With protocol I three hypoglycemias (greater than 4 mM) and three hypokalemias (greater than 3 mEq/l) did occur. With protocol II no hypoglycemia and only one moderate hypokalemia was observed. Thus, continuous infusion of insulin added to the rehydration solution, including isotonic bicarbonate, isotonic saline, glucose and electrolytes is as effective as discontinuous insulin infusion, but with a lower incidence of complications. In addition, this method has the advantage of being easy and applicable everywhere.
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D016883:Diabetic Ketoacidosis / Q000628:therapy*; D005440:Fluid Therapy; D006801:Humans; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use; D007657:Ketone Bodies / Q000652:urine; D011188:Potassium / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies; D011188:Potassium
vernacular_title: Traitement de l'acidocétose diabétique sévère de l'enfant. Etude comparative de deux méthodes.