Gabaergic regulation of nigrostriatal neurons: coupling of benzodiazepine and GABA receptors.
1. The GABA agonist muscimol and the benzodiazepine diazepam both decrease dopamine (DA) release in the rat nigrostriatal pathway. 2. These actions are reversed by the GABA antagonist picrotoxin and in the case of diazepam, by the benzodiazepine antagonist RO151788. 3. Our data support an inhibitory GABAergic regulation of nigrostriatal DA neurons and indicate the presence of a GABA/benzodiazepine receptor complex on these neurons.
D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D003975:Diazepam / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000502:physiology*; D011963:Receptors, GABA-A; D013378:Substantia Nigra / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003975:Diazepam; D004298:Dopamine