[Mechanism of calcium channel operation in the neuronal membranes of rat spinal ganglia].
A model of the calcium channel functioning is developed which provides a satisfactory description for the results of the experiments with intracellular injection of 3.5-cycloadenosine monophosphate (cAMP) into neurons of rat dorsal root ganglions. According to the model, the value of the intracellular concentration of cAMP necessary for keeping the calcium channels in the functioning state is equal to 10(-4)-10(-5)M. It is also shown that the neurons investigated contain a high-molecular factor whose interaction with cAMP molecules predetermines the active state of calcium channels.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D000242:Cyclic AMP / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D051381:Rats
D007473:Ion Channels; D000242:Cyclic AMP; D002118:Calcium
Mekhanizm funktsionirovaniia kal'tsievogo kanala v membrane neĭronov spinal'nykh gangliev krys.