Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus.
Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.
D004837:Epinephrine / Q000494:pharmacology; D006418:Heme; D010084:Oxidation-Reduction; D010974:Platelet Aggregation / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects
D011942:Receptors, Adrenergic, alpha; D006418:Heme; D004837:Epinephrine