Forskolin as an activator of cyclic AMP accumulation and secretion in blowfly salivary glands.
Forskolin is a diterpene that activates adenylate cyclase in a variety of mammalian cells. In addition of forskolin to blowfly salivary glands increased cyclic AMP accumulation and salivary secretion. There was a small increase in transepithelial movement of labelled Ca2+. Forskolin did not induce breakdown of labelled phosphatidylinositol or inhibit the stimulation of phosphatidylinositol breakdown caused by 5-hydroxytryptamine. These data indicate that forskolin can mimic all the effects of 5-hydroxytryptamine on salivary-gland secretion that have been attributed to cyclic AMP.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D005576:Colforsin; D000242:Cyclic AMP / Q000378:metabolism*; D004175:Diptera / Q000378:metabolism*; D004224:Diterpenes / Q000494:pharmacology*; D066298:In Vitro Techniques; D012469:Salivary Glands / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology; D013268:Stimulation, Chemical
D004224:Diterpenes; D005576:Colforsin; D012701:Serotonin; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D002118:Calcium