title: Structure and function of the hepatitis B virus genome.
abstract: A preliminary map of the hepatitis B virus genome has been derived from the nucleotide sequence of cloned human hepatitis virus (HBV) DNA. The genes for two viral antigens were identified and their expression was studied using SV40 vector systems. HBV DNA cloned and amplified in bacteria induces hepatitis in chimpanzees demonstrating that the cloned HBV DNA is functionally intact.
mesh_terms: D001483:Base Sequence; D003001:Cloning, Molecular; D003062:Codon; D004262:DNA Restriction Enzymes; D005814:Genes, Viral; D014644:Genetic Variation; D006512:Hepatitis B Core Antigens / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D013539:Simian virus 40 / Q000235:genetics
chemical_list: D003062:Codon; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D004262:DNA Restriction Enzymes