title: Trilostane in the management of Cushing's syndrome.
abstract: Trilostane has been used to treat 6 patients with Cushing's syndrome, 4 with an adrenal adenoma and 2 with pituitary driven disease. Three patients responded clinically and biochemically to trilostane. Although effective in some cases of Cushing's syndrome, the variability of the effect of trilostane may limit its usefulness as a therapeutic agent.
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003480:Cushing Syndrome / Q000188:drug therapy*; D013196:Dihydrotestosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D013196:Dihydrotestosterone; D000324:Adrenocorticotropic Hormone; C009954:trilostane; D006854:Hydrocortisone