title: Down regulation and recovery of the epidermal growth factor receptor in serum supplemented versus defined medium.
abstract: The down regulation of surface membrane receptors for 125I) epidermal growth factor (EGF) has been evaluated in normal and SV40-transformed human fibroblasts (WI38) under conditions of serum-supplemented versus defined growth media. Both normal and transformed WI38 cells down regulate and recover the EGF receptor and these processes do not differ significantly in serum-supplemented versus defined media. These data are in contrast to a recent study that reported that the HeLa cell does not down regulate the EGF receptor in defined media, whereas it does in serum-supplemented media.
mesh_terms: D002455:Cell Division; D002460:Cell Line; D002472:Cell Transformation, Viral; D003470:Culture Media; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013539:Simian virus 40
chemical_list: D003470:Culture Media; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D066246:ErbB Receptors