Chronic enterocyte infection with coronavirus. One possible cause of the syndrome of tropical sprue?
A man with a gastrojejunostomy and intestinal malabsorption was found to be excreting large numbers of coronavirus-like particles in his stools over a period of at least eight months. Coronavirus-like particles were found in vesicles in degenerating jejunal enterocytes in all of five jejunal biopsies. In a review of electron micrographs, similar structures were found in biopsies from three of 12 patients with classical chronic tropical sprue and in one patient with a sprue-like syndrome associated with agammaglobulinaemia. The hypothesis is advanced that infection with this virus may produce enterocyte damage and may be one cause of the syndrome of tropical sprue.
D003333:Coronaviridae Infections / Q000382:microbiology; D006801:Humans; D007410:Intestinal Diseases; D008286:Malabsorption Syndromes / Q000209:etiology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D013182:Sprue, Tropical / Q000209:etiology* / Q000382:microbiology