title: Glucagonomas. Ultrastructure and immunocytochemistry.
abstract: Pancreatic tumors harboring glucagon immunoreactive cells were found in four patients with diabetes mellitus. Alpha-cell (glucagon) granules were present in three tumors; pancreatic polypeptide (PP) immunoreactive cells were detected in two. In two patients the tumors were malignant and one of these had the glucagonoma syndrome; the other was a member of a family with MEN-type I syndrome. These cases illustrate three clinical subtypes of glucagonoma.
mesh_terms: D007516:Adenoma, Islet Cell / Q000648:ultrastructure*; D000368:Aged; D048909:Diabetes Complications; D005260:Female; D005934:Glucagon / Q000032:analysis; D005935:Glucagonoma / Q000150:complications / Q000648:ultrastructure*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000648:ultrastructure*; D010191:Pancreatic Polypeptide / Q000032:analysis
chemical_list: D010191:Pancreatic Polypeptide; D005934:Glucagon