[Use of cyproheptadine (Peritol) as a drug blocking corticotropin secretion in the treatment of Cushing's syndrome].
The results are presented of the combined drug treatment of 39 patients with Icenko-Cushing's disease, using steroidogenesis inhibitor chloditane (o.p-DDD) and corticotropin secretion blocker peritol (cyproheptadine). The control group of 40 patients, suffered from the above disease of the same severity, was treated with alone chloditane. In the control group the inhibition of the adrenocortical glucocorticoid activity by chloditane was accompanied by twofold increase in the blood plasma corticotropin level. The relapse was noted in 24 of 40 patients after 5 to 6 months. The inhibition of glucocorticoid activity did not induce corticotropin secretion activation in patients, treated with chloditane and peritol. At the delayed terms of the treatment course the basal level of plasmatic corticotropin continued to lower and averaged the subnormal values. Relapses of the disease were seen in only 8 of 39 patients. The combined chloditane-perikol treatment of Icenko-Cushing's disease is likely to be perspective.
D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003480:Cushing Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D003533:Cyproheptadine / Q000008:administration & dosage*; D003864:Depression, Chemical; D004359:Drug Therapy, Combination; D006727:Hormone Antagonists; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000378:metabolism; D008939:Mitotane / Q000008:administration & dosage
D006727:Hormone Antagonists; D003533:Cyproheptadine; D008939:Mitotane; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Primenenie tsiprogeptadina (peritola) v kachestve medikamentoznog sredstva vozdeĭstviia na sekretsiiu kortikotropina pri lechenii bolezni Itsenko-Kushinga.