A significant role of proximity of HVJ-antigen in the generation of tumor immunity.
According to the blocking test for proximity of cell surface antigens, L1210 leukemia-associated antigen was not linked to molecules carrying H-2d antigen or murine leukemia virus-associated antigen, but there was a close association between HVJ-associated antigen and L1210 leukemia-associated antigen on the surface membrane of HVJ-pi-infected L1210 leukemia cells. Once L1210 leukemia cells were infected with HVJ-pi, their adsorptive power was found to be greater than that of uninfected cells by quantitative absorption analysis. These phenomena may lead to a better recognition by the host of L1210 leukemia-associated antigen, followed by generation of tumor immunity.
D000042:Absorption; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D006183:H-2 Antigens / Q000276:immunology; D007939:Leukemia L1210 / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010222:Parainfluenza Virus 1, Human / Q000276:immunology*; D013499:Surface Properties
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D000956:Antigens, Viral; D006183:H-2 Antigens