title: Comparative tumor initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons.
abstract: 6-Nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene, and the corresponding parent hydrocarbons were tested for tumor initiating activity on mouse skin with promotion by tetradecanoylphorbol acetate. The initiating doses of 6-nitrobenzo[a]pyrene and benzo[a]pyrene were 0.05 mg each; for all other compounds the initiating doses were 1.0 mg. 6-Nitrochrysene induced tumors in 60% of the mice (2.1 tumors per mouse), but was significantly less tumorigenic than chrysene. 3-Nitroperylene induced tumors in 42% of the mice (0.5 tumors per mouse) and was significantly more active than perylene. Neither 1-nitropyrene nor 6-nitrobenzo[a]pyrene exhibited significant tumorigenic activity in the concentrations tested.
mesh_terms: D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000633:toxicity*; D002273:Carcinogens; D002911:Chrysenes / Q000633:toxicity*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009574:Nitro Compounds; D010569:Perylene / Q000031:analogs & derivatives / Q000633:toxicity*; D010616:Phenanthrenes / Q000633:toxicity*; D011721:Pyrenes / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced*
chemical_list: D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D002273:Carcinogens; D002911:Chrysenes; D009574:Nitro Compounds; D010616:Phenanthrenes; D011721:Pyrenes; C035987:3-nitroperylene; D001564:Benzo(a)pyrene; D010569:Perylene; C034699:6-nitrobenzo(a)pyrene; C035986:6-nitrochrysene; C032668:1-nitropyrene