title: Papovavirus-related RNA sequences in human neurogenic tumours.
abstract: Thirty-two human brain tumours were investigated for the presence of papovavirus-related RNA sequences. Radiolabelled viral DNAs isolated from SV40, BKV, HDV, and BPV were hybridized in-situ on to tumour kryostat sections under conditions that detect complementary RNA. SV40-related RNA was detectable in 34% of all tumours tested but was not found in normal human brain tissue. SV40-positive tumours included 1/1 angiofibroma, 1/4 astrocytomas, 2/4 metastatic brain tumours, 1/1 melanoma, 3/7 meningiomas, 2/4 neurinomas, 1/2 oligodendrogliomas. Bovine papilloma virus-, BKV-, and HDV-related RNAs were absent from all tissues tested. The presence of SV40-related nucleic acids in a large number of human neurogenic tumours may reflect a viral involvement in the etiology of these tumours.
mesh_terms: D001254:Astrocytoma / Q000032:analysis; D001932:Brain Neoplasms / Q000032:analysis*; D018219:Histiocytoma, Benign Fibrous / Q000032:analysis; D006801:Humans; D008545:Melanoma / Q000032:analysis; D008577:Meningeal Neoplasms / Q000032:analysis; D008579:Meningioma / Q000032:analysis; D009442:Neurilemmoma / Q000032:analysis; D009693:Nucleic Acid Hybridization; D009837:Oligodendroglioma / Q000032:analysis; D027383:Papillomaviridae; D027382:Polyomaviridae; D012367:RNA, Viral / Q000032:analysis*
chemical_list: D012367:RNA, Viral