[Effect of passive immunization with an antiCRF antiserum on the secretion of ACTH in rats].
A peptide with 41-residue having CRF activity both in vivo and in vitro has recently been isolated from ovine hypothalami (41-CRF). Passive immunization of Sprague-Dawley Rats with an antiserum against this peptide is followed by a significant decrease in plasma ACTH and cortisosterone levels under basal conditions as well as after ether-stress and adrenalectomy. These data demonstrate that 41-CRF plays a major role in the physiological regulation of ACTH secretion.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology / Q000494:pharmacology*; D007116:Immunization, Passive; D008297:Male; D010455:Peptides / Q000276:immunology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D007106:Immune Sera; D010455:Peptides; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone
Effet de l'immunisation passive avec un sérum anti-CRF sur la sécrétion d'ACTH du rat.