Malignant rhabdoid tumor of the kidney. Histopathology, ultrastructure and comments on differential diagnosis.
Clinical and histopathological features of two cases of malignant rhabdoid tumor of the kidney are presented. One of these cases was also studied by electron microscopy. Histologically, both tumors consisted of an admixture of undifferentiated polygonal or elongated cells and cells with abundant eosinophilic cytoplasm frequently containing hyaline globular structures. Ultrastructurally, these cytoplasmic inclusions were composed of large masses of actin-size and intermediate-size filaments. The poor prognosis of this type of tumor is emphasized and histological criteria for differential diagnosis from other malignant renal tumors of childhood and adolescence are discussed.
D003937:Diagnosis, Differential; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D012208:Rhabdomyosarcoma / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D009396:Wilms Tumor / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure