The effect of tetrodotoxin on the synaptic and extrasynaptic membrane in frog skeletal muscle.
Tetrodotoxin resistant sodium channels have been shown to operate in frog muscle membrane, which are responsible for local action potentials. These channels are located mainly in synaptic regions, and their distribution on the membrane is controlled by neurotrophic factors.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D009121:Muscle Denervation; D009132:Muscles / Q000502:physiology*; D011896:Rana temporaria; D012964:Sodium / Q000378:metabolism; D013570:Synaptic Membranes / Q000187:drug effects* / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology*
D007473:Ion Channels; D013779:Tetrodotoxin; D012964:Sodium