title: The ontogeny of delta-9-tetrahydrocannabinol responsiveness in the rabbit.
abstract: An autosomal recessive condition (thc/thc) in our closed colony of New Zealand White rabbits (Uaz:NZW-thc) results in nonfatal, behavioral convulsions following intravenous (i.v.) injections of delta-9-tetrahydrocannabinol (THC) and other psychoactive cannabinoids of marijuana. The ontogeny of the convulsive response was evaluated in potential THC-seizure-susceptible (SS) rabbits from postnatal Days (PN) 15-548. Ages of nonsusceptibility (PN 15-23), partial susceptibility (PN 24-38), and complete susceptibility (PN 39-548) were found. Also, open-field activity was determined in PN 14-25 THC-SS and THC-seizure-resistant (SR) rabbits. Administration of THC during the seizure-insensitive period resulted in genotype-dependent alternations in photocell activity and sprawling.
mesh_terms: D000367:Age Factors; D000818:Animals; D013759:Dronabinol / Q000008:administration & dosage / Q000009:adverse effects*; D005808:Genes, Recessive; D009043:Motor Activity / Q000187:drug effects; D011817:Rabbits / Q000235:genetics*; D012640:Seizures / Q000139:chemically induced* / Q000235:genetics
chemical_list: D013759:Dronabinol