Characterization of beta-adrenergic receptors on human cerebral microvessels.
Cerebral microvessels were separated and prepared from human brain cortex by albumin floatation and glass bead filtration. The binding of a specific beta-adrenergic antagonist, (125I) iodohydroxybenzylpindolol, to the microvessel preparation was characterized by high affinity, saturability, and stereospecificity. The presence of specific beta-adrenergic receptor sites in human cerebral microvessels supports the hypothesis of adrenergic regulation of the function of cerebral microvessels.
D001921:Brain / Q000098:blood supply*; D006801:Humans; D008833:Microcirculation; D011941:Receptors, Adrenergic / Q000033:anatomy & histology*; D011943:Receptors, Adrenergic, beta / Q000033:anatomy & histology* / Q000378:metabolism
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta