Concurrence of malignant and benign heterologous mixed tumors of the uterus.
A large polypoid uterine mas was composed to two distinct and separate parts: a malignant mixed müllerian tumor (MMMT) and a benign mixed mesenchymal tumor (BMMT). It was considered a collision of two neoplasms rather than a malignant degeneration of the BMMT. Malignant transformation of benign mesenchymal uterine tumors is a controversial concept which is difficult to prove or disprove. Concerning the histogenesis of MMMT it appears, at least in some cases, that they originate not from a single multipotential mullerian cell, but rather from two, a stromal cell and an epithelial cell. It is suggested furthermore, that in certain instances presence of one neoplastic component, e.g., adenocarcinoma, can incite proliferation of the second, sarcomatous element of the MMMT.
D000368:Aged; D002471:Cell Transformation, Neoplastic; D005260:Female; D006391:Hemangioma / Q000473:pathology*; D006801:Humans; D008067:Lipoma / Q000473:pathology*; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*