Small t protein of simian virus 40 is required for dense focus formation in a rat cell line.
Incomplete foci were formed in a Fischer rat cell line infected with simian virus 40 detection mutants encoding defective small t antigen. The foci were small and rarely piled up. The fraction of DNA-synthesizing cells in the foci was about half of that induced by wild-type virus.
D000818:Animals; D000956:Antigens, Viral / Q000502:physiology*; D000957:Antigens, Viral, Tumor; D001921:Brain; D002460:Cell Line; D002472:Cell Transformation, Viral; D004247:DNA / Q000096:biosynthesis; D051381:Rats; D011916:Rats, Inbred F344; D013539:Simian virus 40 / Q000502:physiology*
D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor; D004247:DNA