title: [First human case of Drechslera longirostrata mycosis. Spondylodiscitis complicating prosthesis endocarditis. Treatment with combined ketoconazole and amphotericin B].
abstract: In a patient with spondylodiscitis secondary to cardiac valve prosthesis infection with endocarditis the fungus Drechslera longirostrata, which had not yet been known to cause mycoses, was isolated from cultures of prosthetic material and an intervertebral disc. The cardiac prosthesis had to be replaced and the vertebral lesion, which extended along 3 lumbar segments and was destructive enough to produce neurological disorders, required surgical immobilization of the spine. The disc infection was cured after combined administration of amphotericin B and ketoconazole, both drugs having proved unsuccessful when given alone. Infections caused by rare opportunistic fungi are becoming increasingly common and are difficult to diagnose since immunological methods are inapplicable. In some resistant or extremely severe fungal infections antifungal agents can be used in combinations for their synergistic effects, with subsequent reduction of dosage and potential side-effects. Combinations must be based on in vitro sensitivity tests.
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage*; D004696:Endocarditis / Q000209:etiology*; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D007654:Ketoconazole; D003904:Mitosporic Fungi; D009181:Mycoses / Q000188:drug therapy; D010879:Piperazines / Q000008:administration & dosage; D011183:Postoperative Complications / Q000209:etiology*; D013166:Spondylitis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D000666:Amphotericin B; D007654:Ketoconazole
vernacular_title: Premier cas humain de mycose à Drechslera longirostrata. Spondylodiscite compliquant une endocardite sur prothèse. Traitement par l'association kétoconazole-amphotéricine B.