Analysis of creams. II. Quantitative determination of drugs in creams by titration in non-aqueous solvents.
The possibilities for the determination of active components in creams by acid-base titrations in non-aqueous solvents were investigated. Interference by cream-base components with the titration of weak organic bases and their halides with perchloric acid in acetic acid, and with the titration of weak acids with tetrabutylammonium hydroxide in N,N-dimethylformamide were studied. It appeared to be possible to determine alkaloid halides, salicylic acid, hexachlorophene and methyl salicylate without previous clean-up of the cream samples.
D009824:Ointments / Q000032:analysis*; D010472:Perchlorates; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011199:Potentiometry / Q000379:methods; D000644:Quaternary Ammonium Compounds; D012997:Solvents
D009824:Ointments; D010472:Perchlorates; D004364:Pharmaceutical Preparations; D000644:Quaternary Ammonium Compounds; D012997:Solvents; C009405:tetrabutylammonium