Evidence against a requirement for phospholipid methylation in adenylate cyclase activation by hormones. Methyltransferase inhibitors do not impair cyclic AMP accumulation induced by glucagon or beta-adrenergic agents in rat hepatocytes.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology*; D006710:Homocysteine / Q000494:pharmacology; D007536:Isomerism; D007545:Isoproterenol / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012435:S-Adenosylhomocysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D014372:Tubercidin / Q000494:pharmacology
D010743:Phospholipids; C018258:3-deazaadenosine; D006710:Homocysteine; C033256:S-(3-deazaadenosyl)homocysteine; D005934:Glucagon; D012435:S-Adenosylhomocysteine; D000242:Cyclic AMP; D008780:Methyltransferases; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D014372:Tubercidin; D004837:Epinephrine