Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids.
Fusions between the mouse mammary tumour virus long terminal repeat and a mouse dihydrofolate reductase cDNA have been constructed in a SV40 vector. When these plasmids are transferred into recipient cells, the production of dihydrofolate reductase is regulated by glucocorticoid hormones. These results define a hormonally responsive region of the viral genome.
D000818:Animals; D001483:Base Sequence; D002472:Cell Transformation, Viral / Q000187:drug effects*; D003001:Cloning, Molecular; D004274:DNA, Recombinant / Q000378:metabolism; D005938:Glucocorticoids / Q000494:pharmacology*; D008324:Mammary Tumor Virus, Mouse / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D051379:Mice; D010957:Plasmids / Q000187:drug effects*; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*
D004274:DNA, Recombinant; D005938:Glucocorticoids; D013762:Tetrahydrofolate Dehydrogenase