[Protective effect of isaxonine against vincristine-induced neuropathy (author's transl)].
A double-blind survey versus a placebo was carried out with C.P.V. protocole on 25 patients treated for lymphosarcoma or reticulosarcoma; its aim was to appraise the preventive action of isaxonine on the appearance of neuropathy induced by vincristine. The frequency of such neuropathy was clearly lower in the isaxonine group (3/10) than in the placebo group (8/10) in a statistically significant manner. The protective effect of isaxonine was particularly striking on tendon reflexes and on the number of motor units recorded at musculus extensor digitirum pedis brevis; on the contrary, the patients treated with the placebo showed real denervation.
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004341:Drug Evaluation; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000517:prevention & control*; D011743:Pyrimidines / Q000627:therapeutic use*; D014750:Vincristine / Q000009:adverse effects / Q000037:antagonists & inhibitors*
D011743:Pyrimidines; D014750:Vincristine; C020375:isaxonine
Activité protectrice de l'isaxonine dans la neuropathie à la vincristine.