title: Angiofollicular lymph node hyperplasia and peripheral neuropathy: association with monoclonal gammopathy.
abstract: An elderly man was found to have the plasma cell variant of angiofollicular lymph node hyperplasia. His course was complicated by peripheral neuropathy and generalized lymphadenopathy, which improved after a trial of corticosteroid therapy. Although the plasma cell variant has been associated with multiple systemic effects, including the nephrotic syndrome, growth failure, fever, hyperglobulinemia, and anti-erythropoietin-mediated anemia, concurrent peripheral neuropathy has only occasionally been reported. Angiofollicular lymph node hyperplasia should be included in the differential diagnosis of peripheral neuropathy associated with lymphadenopathy or a mediastinal mass. A discussion of the clinical, histologic, and immunopathologic characteristics of angiofollicular lymph node hyperplasia is presented.
mesh_terms: D004586:Electrophoresis; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D006965:Hyperplasia; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D007074:Immunoglobulin G; D011241:Prednisone