Laboratory evaluation of a living attenuated vaccine against bluetongue type 20 virus.
Living attenuated bluetongue Type 20 virus vaccine was tested in 9 to 12 month-old Australian Merino sheep, held in air conditioned, insect-free accommodation. The vaccine appeared avirulent and immunogenic and protected against infection with a second dose of homologous vaccine virus. No enhancement of virulence or significant change in immunogenicity was observed when the vaccine was passaged 3 times through sheep without antibody to bluetongue virus.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001819:Bluetongue / Q000517:prevention & control*; D001820:Bluetongue virus / Q000276:immunology* / Q000472:pathogenicity; D008297:Male; D009500:Neutralization Tests; D012087:Reoviridae / Q000276:immunology*; D012756:Sheep; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology; D014766:Viremia / Q000662:veterinary; D014774:Virulence
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines