[Study of the effect of a dexamethasone-containing antirheumatic on the hypothalomus-adenohypophysis-adrenocortical system].
The aim of this study was to investigate the effect of an analgesic-antirheumatic fixed combination drug containing dexamethasone (Ambene) on this endocrine system. 10 healthy volunteers received an intramuscular injection of Ambene as either single dose once, single dose on three consecutive days or on three alternating days. Early morning ACTH plasma concentrations, endogenous cortisol profiles and dexamethasone kinetics were determined and insulin-hypoglycemia tests stimulated stress conditions before, during and after Ambene-application. In all cases treatment led to short-term suppression of the reactability of the Hypothalamus-Anteropituitary Corticoadrenal System. Three days after single dose or alternating day administration for three days reactions of this endocrine system were completely restored, while after administration on three consecutive days there still was a slight decrease in basal and insulin-stimulated cortisol values. The short half-life of water soluble dexamethasone in Ambene appears to be the reason for the rapid restitution of this endocrine system.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000632:Aminopyrine / Q000494:pharmacology*; D003907:Dexamethasone / Q000378:metabolism / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007328:Insulin / Q000097:blood; D008297:Male; D008954:Models, Biological; D010653:Phenylbutazone / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D013831:Thiamine / Q000494:pharmacology*; D013997:Time Factors; D014805:Vitamin B 12 / Q000494:pharmacology*
D004338:Drug Combinations; D007328:Insulin; D000632:Aminopyrine; D003907:Dexamethasone; C036446:aminopyrine, dexamethasone, phenylbutazone, thiamine, vitamin B12 drug combination; D000324:Adrenocorticotropic Hormone; D010653:Phenylbutazone; D014805:Vitamin B 12; D006854:Hydrocortisone; D013831:Thiamine
Prüfung der Wirkung eines Dexamethason-haltigen Antirheumatikums auf das Hypothalamus-Hypophysenvorderlappen-Nebennierenrinden-System.