Influence of sulpiride-induced hyperprolactinemia on baboon menstrual cycles: a longitudinal study.
The influence of sulpiride-induced hyperprolactinemia on the hypothalamic-pituitary-ovarian function of the baboon (Papio cynocephalus) was investigated. Plasma levels of prolactin, LH, FSH, estrone, estradiol, 17-hydroxyprogesterone, progesterone and 20 alpha-dihydroprogesterone in control and consecutive treatment cycles (sulpiride i.m. injections 100 mg/day) were determined serially. The hormonal changes indicate that the ovary is the most sensitive site to the direct inhibitory action of sulpiride-induced hyperprolactinemia.
D000818:Animals; D004967:Estrogens / Q000097:blood; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects; D010215:Papio / Q000502:physiology*; D011372:Progestins / Q000097:blood; D011388:Prolactin / Q000097:blood*; D013469:Sulpiride / Q000494:pharmacology*
D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D011372:Progestins; D013469:Sulpiride; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone