[Comparative study of beta-adrenoreceptors of rat brain synaptic membranes].
Affinity of beta-adrenoreceptors in the rat brain synaptic membranes to agonists isoproterenol and norepinephrine, as well as to antagonist 125I-hydroxybenzylpindolol is lower in young (1 month) and old (24--26 months) than in mature (8--12 months) rats. Desensitization toward isoproterenol is expressed in the young ones only. In the old but not in other groups simultaneous action of isoproterenol and N-ethylmaleimide decreases the following binding of the antagonist while the same agents added separately produced no effect. It is suggested that beta-adrenoreceptors undergo age-related changes in their conformational state due to modification of the membrane environment.
D000375:Aging; D000818:Animals; D001592:Benzyl Alcohols / Q000378:metabolism; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D007545:Isoproterenol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013379:Substrate Specificity; D013570:Synaptic Membranes / Q000378:metabolism*
D001592:Benzyl Alcohols; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; C012357:hydroxybenzylpindolol; D010869:Pindolol; D007545:Isoproterenol; D009638:Norepinephrine
Sravnitel'noe issledovanie beta-adrenoretseptorov sinapticheskikh membran mozga.