Effect of benzo[a]pyrene on sister-chromatid exchange in fetal hamster liver exposed in utero.
Benzo[a]pyrene between 50 and 125 mg/kg administered maternally caused a dose-related increase in sister-chromatid exchange in fetal hamster liver cells. There was no difference on days 11, 13 and 15 of gestation in the sensitivity of fetal liver to benzo[a]pyrene.
D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000494:pharmacology*; D006224:Cricetinae; D003434:Crossing Over, Genetic / Q000187:drug effects*; D005260:Female; D005333:Fetus; D005865:Gestational Age; D008099:Liver / Q000187:drug effects / Q000196:embryology*; D008431:Maternal-Fetal Exchange; D009153:Mutagens / Q000494:pharmacology*; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001580:Benzopyrenes; D009153:Mutagens; D001564:Benzo(a)pyrene