title: Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia.
abstract: The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D003214:Conditioning, Classical; D009020:Morphine / Q000037:antagonists & inhibitors*; D010146:Pain / Q000503:physiopathology*; D011956:Receptors, Cell Surface / Q000502:physiology; D011957:Receptors, Opioid / Q000187:drug effects*
chemical_list: D011956:Receptors, Cell Surface; D011957:Receptors, Opioid; D009020:Morphine; D002766:Cholecystokinin