[Current theories on the nature of myoepithelial cells and their role in the morphogenesis of dyshormonal hyperplasia and breast neoplasms].
An analysis of current concepts on the origin and potentials of neoplastic transformation of myoepithelial cells (MC) of the mammary glands is presented. The epithelial and smooth-muscle nature of these cells is discussed. The hypothesis of mixed (epithelial and myoepithelial) nature of mammary gland carcinoma and possibilities of neoplastic transformation of poorly-differentiated forms of MC are considered. Methods for identification of cells of the myoepithelial origin are described.
D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology*; D006801:Humans; D009132:Muscles / Q000473:pathology*; D009208:Myoepithelioma / Q000209:etiology* / Q000473:pathology
Sovremennye predstavleniia o prirode mioépitelial'nykh kletok i uchastii ikh v morfogeneze disgormonal'nykh giperplaziĭ i opukholeĭ molochnykh zhelez.