Regulation of glutamate receptors: possible role of phosphatidylserine.
The polar head group of the phospholipid phosphatidylserine is similar in structure to the glutamate analogue 2-amino-4-phosphonobutyric acid (APB), an antagonist of excitatory transmission in the brain. When tested in ligand binding assays phosphatidylserine and its polar head group components O-phosphoserine and L-alpha-glycerophosphoserine were good displacers of APB-sensitive L-glutamate binding. The polar head group components were also antagonists of synaptic field potentials in the rat dentate gyrus evoked by stimulation of a presumed glutamate-using pathway. These results suggest that phosphatidylserine may regulate the activity of synaptic L-glutamate receptors.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects; D005971:Glutamates / Q000378:metabolism*; D007700:Kinetics; D010718:Phosphatidylserines / Q000494:pharmacology*; D010743:Phospholipids / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D017470:Receptors, Glutamate
D005971:Glutamates; D010718:Phosphatidylserines; D010743:Phospholipids; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate