title: [Insensitivity of some rats to intraperitoneal injections of collagenase and trypsin].
abstract: In the rat peritoneal injections of collagenase or trypsin give rise to severe lesions. In our experience 20% of the animals remain intact. The frequency of lesions increases with older and heavier subjects. Moreover 25% of the rats who remained free of lesions after a first injection of collagenase resist to a second one. This shows that they are strongly protected against the enzyme. The exact nature and location of this protective mechanism are not known.
mesh_terms: D000818:Animals; D004351:Drug Resistance; D007274:Injections, Intraperitoneal; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014357:Trypsin; D003012:Microbial Collagenase
vernacular_title: Insensibilité de certains rais aux injections intrapéritonéales de collagénase et de tryspine.