Naloxone antagonism of the thermoregulatory effects of phencyclidine.
Phencyclidine elicits hyperthermia at low doses and hypothermia at high doses in rats. Naloxone antagonizes both effects. Phencyclidine's effects on thermo-regulation are probably mediated by an interaction with a mu opiate receptor.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D009270:Naloxone / Q000494:pharmacology; D010622:Phencyclidine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects*
D011957:Receptors, Opioid; D009270:Naloxone; D010622:Phencyclidine