Sympatho-adrenal regulation of adipose tissue blood flow in dog and man.
1. A comparison is made between the sympatho-adrenal regulation of subcutaneous adipose tissue blood flow in the dog and in man. 2. In the dog neuronally released noradrenaline causes vasoconstriction in subcutaneous adipose tissue by preferential activation of alpha-adrenoceptors located close to the sympathetic nerve terminals. 3. In man sympathetic reflex activation also causes vasoconstriction in subcutaneous adipose tissue, presumably via activation of alpha-adrenoceptors. 4. The adipose tissue vascular beta-adrenoceptors are of the beta 1-subtype in the dog and the beta 2-subtype in man. 5. Because of this adrenaline causes vasoconstriction in dog adipose tissue and vasodilation in human adipose tissue.
D000273:Adipose Tissue / Q000098:blood supply*; D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D002395:Catecholamines / Q000097:blood; D004285:Dogs; D004558:Electric Stimulation; D006801:Humans; D066298:In Vitro Techniques; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D013045:Species Specificity; D013564:Sympathetic Nervous System / Q000502:physiology*
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta