HLA antigens in patients with recrudescent herpes simplex infections.
We have assessed the humoral and cellular immune responses to HSV-1 antigen in normal controls, and in 47 subjects with recurrent cold sores. THe antigens at the HLA-ABC and DR loci were examined in the first group of 21 susceptible subjects. An apparent increase in prevalence of A9 seen in this group was confirmed in a prospective study of a further 26 subjects (P less than 0.0005). In contrast to previous studies, no relationship was noted between the immune responses and HLA antigens.
D000956:Antigens, Viral; D006680:HLA Antigens / Q000235:genetics; D006561:Herpes Simplex / Q000235:genetics / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D018139:Simplexvirus / Q000276:immunology
D000956:Antigens, Viral; D006680:HLA Antigens