Dissociation of aldosterone response to angiotensin II and potassium in the presence of strontium.
the effect of Ca2+, Sr2+ and Ba2+ on aldosterone output was studied in basal conditions and under the stimulus of angiotensin II, potassium and ACTH. Aldosterone production was measured in glomerulosa cells isolated from bovine adrenal glands and incubated in Krebs-Ringer solution in which 1.25 mM Ca2+ was substituted by Sr2+ or Ba2+. Strontium and Ba2+ can substitute for Ca2+ in steroid production when angiotensin II or ACTH were the aldosterone-stimulating agents. The relative aldosterone production was Ca greater than Sr greater than Ba. However, when the steroidogenic effect of potassium was measured under similar conditions, neither Sr2+ nor Ba2+ were able to replace Ca2+ responses. The results suggest a dissociation between the calcium mediated stimulation of aldosterone production by angiotensin II and potassium.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001464:Barium / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002417:Cattle; D011188:Potassium / Q000494:pharmacology*; D013324:Strontium / Q000494:pharmacology*
D000804:Angiotensin II; D001464:Barium; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D011188:Potassium; D002118:Calcium; D013324:Strontium