[Cerebral ischemia after ligature of both carotid arteries in rats: effect of ginkgo biloba extracts (author's transl)].
Simultaneous ligature of both carotid arteries in Long Evans rats results in death for all animals. 50% of the animals survive if the ligatures are separated by a four-day interval. Studies of variations in cerebral blood flow according to the time interval between the two ligatures show that alternative vascularization develops and that the balance between both hemibrains is restored. After giving L-dopa3H to animals with ligature of both carotids, increased synthesis of cerebral dopamine 3H and norepinephrine 3H can be demonstrated. When animals are given extracts of Ginkgo biloba leaves prior to carotid ligatures, survival rate is improved and dopamine synthesis increased, without marked changes in cerebral blood flow. This is related to increased brain cell activity in spite of hypoxia due to carotid ligature.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000209:etiology* / Q000401:mortality; D002339:Carotid Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004298:Dopamine / Q000096:biosynthesis; D007980:Levodopa / Q000494:pharmacology; D008026:Ligation; D009638:Norepinephrine / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
D010936:Plant Extracts; D007980:Levodopa; D004298:Dopamine; D009638:Norepinephrine
Ischémie cérébrale après ligature non simultanée des artères carotides chez le rat: effet de l'extrait de Ginkgo biloba.