Inclusion body fibromatosis.
The clinical and pathological features of two further cases of the condition previously described as Recurring Digital Fibrous Tumour of Childhood are presented. The ultrastructural appearance of the characteristic cell inclusions bears some resemblance to Mallory's hyaline and suggest increased functional activities in the fibroblasts carrying these unusual dense bodies. Retention of abnormal metabolic products in fibroblasts is the most likely explanation. The term Inclusion Body Fibromatosis is proposed for this entity.
D000293:Adolescent; D005260:Female; D005347:Fibroblasts / Q000473:pathology / Q000648:ultrastructure; D005350:Fibroma / Q000473:pathology / Q000648:ultrastructure*; D005385:Fingers / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D012878:Skin Neoplasms / Q000473:pathology / Q000648:ultrastructure*