title: Furosemide and bumetanide-sensitive Na+ fluxes in erythrocytes from genetically hypertensive rats (SHR).
abstract: Na+ and K+ fluxes from erythrocytes of SHR and WKY control rats have been studied. Fluxes were measured in both fresh and sodium-loaded (after exposure to ouabain or PCMBS) erythrocytes. Pump activity appears higher and furosemide or bumetanide sensitive Na+ efflux lower in SHR compared to WKY suggesting a similar abnormality in SHR genetic hypertension as in human hypertension.
mesh_terms: D002731:4-Chloromercuribenzenesulfonate / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002034:Bumetanide / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D005819:Genetic Markers; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D012964:Sodium / Q000097:blood*; D013045:Species Specificity
chemical_list: D005819:Genetic Markers; D002034:Bumetanide; D010042:Ouabain; D002731:4-Chloromercuribenzenesulfonate; D005665:Furosemide; D012964:Sodium; D011188:Potassium