Induction of sister-chromatid exchanges in human lymphocytes by extracts of particulate emissions from a diesel engine.
Particulate matter was collected from the emissions of a diesel-powered engine and the organic components were extracted. The extract induced a dose-related increase in sister-chromatid exchanges in human lymphocytes with a potency of about one-fifth that of benzo[a]pyrene.
D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000494:pharmacology; D002478:Cells, Cultured; D003434:Crossing Over, Genetic / Q000187:drug effects*; D005648:Fuel Oils / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology; D009153:Mutagens / Q000494:pharmacology; D010578:Petroleum / Q000009:adverse effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001580:Benzopyrenes; D005648:Fuel Oils; D009153:Mutagens; D010578:Petroleum; D001564:Benzo(a)pyrene