Corticotropin-releasing factor stimulants adenylate cyclase activity in the anterior pituitary gland.
Ovine corticotropin-releasing factor (CRF) stimulates adenylate cyclase activity in rat anterior pituitary homogenate at an ED50 value of 70 nM. GTP increases the stimulatory effect of CRF on ]32p] cyclic AMP formation in a rat adenohypophysial particulate fraction and in bovine anterior pituitary plasma membranes. The present data show that CRF stimulates adenylate cyclase activity in the anterior pituitary gland at least partly through a guanyl nucleotide-dependent mechanism.
D000262:Adenylyl Cyclases / Q000096:biosynthesis* / Q000378:metabolism; D000818:Animals; D002417:Cattle; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D000242:Cyclic AMP; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D005260:Female; D066298:In Vitro Techniques; D010903:Pituitary Gland, Anterior / Q000201:enzymology*; D051381:Rats; D012756:Sheep / Q000502:physiology
D003346:Corticotropin-Releasing Hormone; D000242:Cyclic AMP; D000262:Adenylyl Cyclases