Suppressive effect of cholecystokinin and its related peptides on beta-endorphin-induced catalepsy in rats.
The effects of the C-terminal octapeptide of cholecystokinin (CCK-8) and its related peptides on the onset and duration of beta-endorphin-induced catalepsy on injection of the peptides into the lateral ventricle were investigated in male rats. The onset of catalepsy was delayed to some extent by nonsulfated CCK-8 and CCK-7 but CCK-8 and caerulein were ineffective. Naltrexone and caerulein significantly shortened the duration of catalepsy, but CCKs were less effective to shorten it. Pentagastrin had no effect on either parameter.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004723:Endorphins / Q000037:antagonists & inhibitors*; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin; D002766:Cholecystokinin