title: A schirrhous anaplastic carcinoma in two dogs resembling mesothelioma.
abstract: The clinical, laboratory, radiographic and pathological findings of two dogs with similar neoplasms are described. Both dogs were mature males of a large breed and had pleural and abdominal effusions containing neoplastic cells. Diffuse scirrhous thickening of the pleura and serosal surfaces was a prominent feature. A fibrous layer containing nests of neoplastic, epithelial-like cells was present on serosal surfaces. The morphological appearance of the cells was suggestive of either an atypical sclerosing mesothelioma or a scirrhous carcinoma. On the basis of ultrastructural and differential staining characteristics, a diagnosis of a scirrhous carcinoma of undetermined primary origin was made in one case and of prostatic urethral origin in the other case.
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D002293:Adenocarcinoma, Scirrhous / Q000175:diagnosis / Q000662:veterinary*; D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000662:veterinary*