title: The pathogenesis of neuropsychiatric lupus.
abstract: Neuropsychiatric lupus is a frequent and serious complication of systemic lupus erythematosus. Although its pathogenesis has not been fully elucidated several mechanisms based on findings in animals and humans have been proposed: cerebral vasculitis; the cross-reaction of lymphocytotoxic antibodies with brain tissue; choroid plexus dysfunction; and the blocking of neurotransmission by noncytotoxic antibodies. Any or all of these mechanisms may be active in a particular patient at a given time.
mesh_terms: D001921:Brain / Q000276:immunology; D002493:Central Nervous System Diseases / Q000209:etiology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000209:etiology; D002831:Choroid Plexus / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000134:cerebrospinal fluid / Q000150:complications* / Q000276:immunology; D009435:Synaptic Transmission; D014657:Vasculitis / Q000150:complications / Q000209:etiology
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M