Role of suppressor cells in feline leukemia virus-associated immunosuppression.
Protein from detergent-disrupted feline leukemia virus was found to suppress lymphocyte blastogenic responsiveness of peripheral blood mononuclear cells from normal cats. When suppressive doses of this protein were substituted for mitogen in the preactivation step of the concanavalin A-induced suppressor cell assay, significant suppression was observed in five of eleven cats tested. These results suggest that feline leukemia virus-associated immunosuppression may be mediated by a virus-induced suppressor cell.
D000818:Animals; D002415:Cats; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects; D005256:Leukemia Virus, Feline / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008722:Methods; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology
D014764:Viral Proteins; D003208:Concanavalin A