Sendai virus causes a rise in intracellular free Ca2+ before cell fusion.
1. Sendai virus caused a large increase in the concentration of free Ca(2+) within human erythrocyte ghosts detected by the Ca(2+)-activated photoprotein obelin. 2. The increase in intracellular [Ca(2+)] preceded fusion. However, fusion could also be observed in the absence of a detectable rise in intracellular free [Ca(2+)]. 3. It was concluded that the increase in intracellular free [Ca(2+)] was not an absolute requirement for cell fusion, but may be necessary to produce fusion at the maximum rate.
D001826:Body Fluids / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D002459:Cell Fusion; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*; D008164:Luminescent Proteins / Q000378:metabolism; D010222:Parainfluenza Virus 1, Human
D008164:Luminescent Proteins; C010497:obelin; D002118:Calcium