On the presence of met 5-enkephalin receptors on the plasma membrane of Deiters' neurons and their modulation of GABA transport.
Met 5-enkephalin blocks the active transport of GABA across plasma membranes of rabbit Deiters' neurons prepared by microdissection. Such an effect is receptor-mediated, being reversed by the antagonist Naloxone. This result shows that Deiters' neurons bear enkephalin receptors, and suggests a hypothesis on the mechanism of enkephalin-mediated neuronal inhibition.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D004723:Endorphins / Q000494:pharmacology*; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000378:metabolism / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism*; D011817:Rabbits; D011957:Receptors, Opioid / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000378:metabolism*; D003689:Vestibular Nucleus, Lateral / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D004723:Endorphins; D004745:Enkephalins; D011957:Receptors, Opioid; D009270:Naloxone; D005680:gamma-Aminobutyric Acid; D004744:Enkephalin, Methionine