The effect of 13-cis-retinoic acid on dibutylnitrosamine induced polyploidy changes in mouse urothelium.
The epithelium in the normal urinary bladder contains cells with diploid to octoploid DNA-content. The carcinogen dibutylnitrosamine (DBN), given subcutaneously in repeated doses causes a loss of polyploidy prior to cancer development. In this study the changes in polyploidy caused by DBN was followed by use of flow cytometry. 13-cis-retinoic acid did not prevent this loss of polyploidy, and did not affect the polyploidy in the normal urothelium.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002352:Carrier Proteins / Q000032:analysis; D004848:Epithelium / Q000187:drug effects; D015474:Isotretinoin; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009602:Nitrosamines / Q000633:toxicity*; D011003:Ploidies / Q000187:drug effects*; D018168:Receptors, Retinoic Acid; D014212:Tretinoin / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects* / Q000648:ultrastructure; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D002352:Carrier Proteins; D009602:Nitrosamines; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; C012279:dibutylnitrosamine; D015474:Isotretinoin