[Channel formation properties of black widow venom].
Black widow venom in the concentration 1--10 mkg/ml added on one side of the bilayer of common bovine brain phospholipids induces the formation of conductivity channels with high cation-anion selectivity with the number of cation transfer for K+, Ca2+, Sr2+, Mg2+, Na+, Cs+, Li+ equaling 0.98, 0.97, 0.96, 0.94. 0.88. 0.82, 0.82 correspondingly (at pH = 7.5). At pH less than 3.5 the channels are slightly selective for anions (the number of cation transfer 0.4). Potential-dependence of the channels is found, which is explained by microstructural reconstruction of their protein complex.
D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D002413:Cations, Divalent; D002414:Cations, Monovalent; D002417:Cattle; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D008051:Lipid Bilayers; D010743:Phospholipids / Q000378:metabolism; D013111:Spider Venoms / Q000494:pharmacology*
D001180:Arthropod Venoms; D002413:Cations, Divalent; D002414:Cations, Monovalent; D007473:Ion Channels; D008051:Lipid Bilayers; D010743:Phospholipids; D013111:Spider Venoms
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