Demonstration of a syncarcinogenic effect of endogenous MuLV, rescued from MNU-induced leukemias, and suboptimal MNU doses in mice.
It was demonstrated that the combined action of activated endogenous MuLV isolated from MNU-induced leukemias and suboptimal doses of MNU yields a significantly high incidence of leukemias and tumors. Treatment with one agent alone shows low effects only. The findings were discussed in view of the mechanisms in which viruses and chemical carcinogens interact in a syncarcinogenic processes.
D000818:Animals; D003043:Cocarcinogenesis; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000209:etiology*; D008770:Methylnitrosourea; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009607:Nitrosourea Compounds
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea