Human interferon-gamma enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-alpha and interferon-beta.
Human interferon-gamma was more effective than interferon-beta or -alpha in stimulating production of immunoassociated antigens; HLA-A, -B, and -C; and beta(2)-microglobulin in human M14 and Namalva cells. The comparison was made on the basis of antiviral units, and the stimulation could be abolished by treatment of the interferon-gamma preparation with pH 2 or anti-interferon-gamma serum.
D000818:Animals; D002460:Cell Line; D006680:HLA Antigens / Q000032:analysis* / Q000276:immunology; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D011817:Rabbits; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development; D014779:Virus Replication; D001613:beta 2-Microglobulin / Q000032:analysis / Q000276:immunology
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D000949:Histocompatibility Antigens Class II; D007370:Interferon Type I; D001613:beta 2-Microglobulin