title: Effect of transection of subfornical organ efferent projections on vasopressin release induced by angiotensin or isoprenaline in the rat.
abstract: Transection of subfornical organ efferents in the rat prevented the vasopressin release in response to intravenous angiotensin II infusion or following a small dose of the beta-sympathomimetic amine isoprenaline (30 micrograms/kg i.m.). In contrast, this lesion had no effect on vasopressin release after hypertonic saline injection or a high dose of isoprenaline (480 micrograms/kg i.m.). We conclude that blood-borne angiotensin II induces vasopressin release by acting on the subfornical organ; depending on the dose of isoprenaline, activation of the endogenous renin-angiotensin system may mediate isoprenaline-induced vasopressin release.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology; D004723:Endorphins / Q000097:blood; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013356:Subfornical Organ / Q000187:drug effects / Q000502:physiology*; D014667:Vasopressins / Q000097:blood*; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D014667:Vasopressins; D000804:Angiotensin II; D001615:beta-Endorphin; D007545:Isoproterenol