title: Effect of protein synthesis inhibition on the induction of cell lysis in Escherichia coli by mecillinam plus nocardicin A.
abstract: Cell lysis can be induced in Escherichia coli by the combined use of the beta-lactam antibiotics nocardicin A and mecillinam. Apparently, the induction of cell lysis occurs by a sequential mechanism in which mecillinam acts first, and nocardicin A has a triggering action insensitive to the inhibition of protein synthesis.
mesh_terms: D000560:Amdinocillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D002701:Chloramphenicol / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D007769:Lactams; D010397:Penicillanic Acid / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D007769:Lactams; D002701:Chloramphenicol; C027318:nocardicin; D010397:Penicillanic Acid; D000560:Amdinocillin