Suppressive effect of dynorphin-(1-13) on luteinizing hormone release in conscious castrated rats.
The effect of intraventricular administration of dynorphin-(1-13) on luteinizing hormone (LH) release was studied in castrated conscious rats. The administration of 5 micrograms of dynorphin-(1-13) into the lateral ventricle inhibited LH secretion. Intravenous administration of naloxone blocked this suppressive effect of dynorphin on LH release. These results suggest a possible role of dynorphin, in addition to beta-endorphin and Met5-enkephalin, in the control of LH release in male rats.
D000818:Animals; D002369:Castration; D004399:Dynorphins; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
D004723:Endorphins; D009294:Narcotics; D010446:Peptide Fragments; D009270:Naloxone; D001615:beta-Endorphin; C026843:dynorphin (1-13); D004399:Dynorphins; D007986:Luteinizing Hormone