[Opiate receptors and sleep. III. Effects of microinjections of DSIP (delta-sleep peptide) in the median thalamus, Periaqueductal gray matter and nucleus of the tractus solitarius of the rabbit (author's transl)].
In the rabbit, microinjections of DSIP (delta-sleep peptide) at optimal doses in the median thalamus, periaqueductal gray matter (22.5 nmol), and nucleus of the tractus solitarius (15.0 nmol) produce slow-wave sleep with abundant recruiting spindles. As is seen with morphine, this effect is blocked by naloxone (160 micrograms intracerebrally; i.c.). At least in the rabbit, DSIP is probably a neurotransmitter or a neuromodulator of the bulbothalamic system inducing slow-wave sleep and particularly recruiting spindles. It is likely to restore slow-wave sleep after supraoptimal awakening i.c. microinjections of morphine.
D000818:Animals; D003701:Delta Sleep-Inducing Peptide; D006993:Hypnotics and Sedatives; D008526:Medulla Oblongata / Q000187:drug effects*; D008636:Mesencephalon / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D011957:Receptors, Opioid / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D013268:Stimulation, Chemical; D013788:Thalamus / Q000187:drug effects*
D006993:Hypnotics and Sedatives; D009842:Oligopeptides; D011957:Receptors, Opioid; D009270:Naloxone; D003701:Delta Sleep-Inducing Peptide
Récepteurs de l'opium et sommeil. III. Effets de micro-injections de DSIP (delta sleep peptide) dans le thalamus médian, la substance grise centrale péri-aqueducale et le noyau du tractus solitaire du lapin.