Epstein-Barr virus in cerebrospinal fluid during infectious mononucleosis encephalitis.
Epstein-Barr virus (EBV) was recovered from cerebrospinal cells (but not from cell-free fluid) of a patient with meningoencephalitis complicating infectious mononucleosis. This finding suggests that virus-altered B lymphocytes can invade the central nervous system and may play a direct role in the pathogenesis of neurologic sequelae of EBV infections. Several mechanisms by which these cells can cause neurologic manifestations are discussed.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000382:microbiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications*; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000150:complications*
D000914:Antibodies, Viral