Differential reactivity of serum antibody from tumor-bearing 15I5 X 7(2) chickens for cross-reactive species of endogenous retroviral envelope glycoprotein.
Experiments were undertaken to determine if the sera of avian sarcoma virus-infected 15I5 X 7(2) chickens exhibit antibody reactivity for species of endogenous retroviral envelope glycoprotein expressed in 15I5 X 7(2) fibroblasts. Two viruses were used for infection of the 15I5 X 7(2) chickens, Pr-A and cl. 85; the envelope glycoprotein of Pr-A, but not of cl. 85, is antigenically cross-reactive with 15I5 X 7(2) endogenous retroviral envelope glycoprotein. Both the Pr-A and cl. 85-infected 15I5 X 7(2) chickens exhibited serum antibody reactivity for the envelope glycoprotein of the endogenous retrovirus RAV-O. In contrast, neither group of infected chickens exhibited detectable serum antibody reactivity for a distinct species of endogenous retroviral envelope glycoprotein, one which though antigenically cross-reactive with the envelope glycoprotein of RAV-O is expressed to much higher levels in 15I5 X 7(2) fibroblasts. Possible mechanisms to account for the observed pattern of antibody reactivity are discussed.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D001354:Avian Leukosis Virus / Q000276:immunology*; D002645:Chickens / Q000276:immunology; D003429:Cross Reactions; D006023:Glycoproteins / Q000276:immunology; D011233:Precipitin Tests; D001357:Sarcoma, Avian / Q000276:immunology*; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006023:Glycoproteins; D014759:Viral Envelope Proteins; D014764:Viral Proteins