Anti-inflammatory mechanism of prozime-10, a proteolytic enzyme.
When Prozime-10 (P-10), a protease extracted from cultured both of Aspergillus melleus, was injected intravenously into anesthetized dogs, plasma ACTH was increased with a latency of 30 min, and this was followed by remarkable elevation of plasma cortisol in many instances. A similar increase in plasma cortisol was elicited after trypsin and alpha-chymotrypsin were injected. Plasma histamine was raised promptly prior to an increase in plasma ACTH after P-10 in every case. However, in certain cases, changes in cortisol occurred simultaneously with ACTH after P-10. Such a rapid elevation of cortisol can be explained, partly, by direct stimulation of the adrenal cortex by histamine.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004285:Dogs; D010450:Endopeptidases / Q000494:pharmacology*; D006632:Histamine / Q000097:blood / Q000494:pharmacology; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism; D066298:In Vitro Techniques; D012697:Serine Endopeptidases
D000893:Anti-Inflammatory Agents; D006632:Histamine; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D010450:Endopeptidases; D012697:Serine Endopeptidases; C026109:oryzin; D006854:Hydrocortisone