Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride.
Adult male Fischer rats were exposed to a necrogenic dose (200 mg/kg) of diethylnitrosamine or to nonnecrogenic doses of N-methyl-N-nitrosourea, 1,2-dimethylhydrazine, or benzo(a)pyrene following partial hepatectomy or sham hepatectomy. This treatment by itself led to no hepatocellular carcinomas by 8 to 18 months, except in animals given N-methyl-N-nitrosourea, which showed a 30% incidence by 12 months. With each treatment regimen, exposure to dietary 2-acetylaminofluorene for 2 weeks coupled with partial hepatectomy or the administration of a necrogenic dose of CCl4, was associated with an incidence of 68 to 94% of cancer at 8, 12, or 18 months, depending upon the initiating carcinogen used. Appropriate controls showed either no hepatocellular carcinoma or a much lower incidence. It is concluded that the 2-week exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or the administration of CCl4 has a strong promoting effect on liver carcinogenesis with four different chemical carcinogens.
D019813:1,2-Dimethylhydrazine; D015073:2-Acetylaminofluorene / Q000008:administration & dosage; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes; D002252:Carbon Tetrachloride Poisoning / Q000150:complications*; D003043:Cocarcinogenesis; D004032:Diet; D004052:Diethylnitrosamine; D004127:Dimethylhydrazines; D006498:Hepatectomy; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000209:etiology; D008297:Male; D008770:Methylnitrosourea; D051381:Rats; D011916:Rats, Inbred F344
D001580:Benzopyrenes; D004127:Dimethylhydrazines; D001564:Benzo(a)pyrene; D004052:Diethylnitrosamine; D008770:Methylnitrosourea; D015073:2-Acetylaminofluorene; D019813:1,2-Dimethylhydrazine