Intracellular modulation of membrane channels by cyclic AMP-mediated protein phosphorylation in peptidergic neurons of Aplysia.
The peptidergic bag cell neurons of the opisthobranch mollusc Aplysia control egg laying and its correlated behavior by release of the neuroactive peptide, egg-laying hormone, during the extended electrical discharge termed afterdischarge. This paper examines the evidence for the involvement of cyclic AMP (cAMP) and protein phosphorylation in the mediation of this electrical afterdischarge. It is concluded that an important component in the mechanism of afterdischarge is the suppression of a potassium channel, mediated by cAMP-dependent protein kinase-induced protein phosphorylation. The exact identity of the potassium channel remains to be worked out.
D000200:Action Potentials; D000818:Animals; D001048:Aplysia / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology*; D005260:Female; D007473:Ion Channels / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000502:physiology; D010058:Oviposition; D010750:Phosphoproteins / Q000502:physiology
D007473:Ion Channels; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D000242:Cyclic AMP