Determination of the radioprotective effects of topical applications of MEA, WR-2721, and N-acetylcysteine on murine skin.
Topical applications of MEA (beta-mercaptoethylamine or cysteamine), WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid], and N-acetylcysteine (NAC) were tested for their ability to protect the normal skin of the hind legs of mice against acute and late damage from single doses of 137Cs radiation. No significant protection was observed with either WR-2721 or NAC. MEA was shown to offer significant protection against acute skin damage in both buffered and unbuffered forms, but no significant protection against late contraction. The use of topical MEA on unanesthetized animals breathing carbogen (95% O2, 5% CO2) appears to give an enhanced level of radioprotection over that shown for anesthetized, air-breathing animals.
D000111:Acetylcysteine / Q000494:pharmacology*; D000287:Administration, Topical; D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D003543:Cysteamine / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology; D011878:Radiotherapy / Q000379:methods*; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*
D009946:Organothiophosphorus Compounds; D002245:Carbon Dioxide; D003543:Cysteamine; C011700:carbogen; D004999:Amifostine; D010100:Oxygen; D000111:Acetylcysteine