Childhood cancer in offspring of two Wilms tumor survivors.
A search was made for cancers among offspring and siblings of 149 Connecticut-born children with Wilms tumor reported to the Connecticut Tumor Registry during 1935 to 1973. Nasopharyngeal rhabdomyosarcoma developed in the daughter of a man with unilateral Wilms tumor that also affected his sister. Hodgkin disease developed in the daughter of a woman who had unilateral Wilms tumor. One other patient had a sibling with Wilms tumor and three had a sibling with other cancers (two Hodgkin disease, one testicular seminoma). The survey suggests an excess risk of other forms of cancer among the progeny and siblings of Wilms tumor patients.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D003237:Connecticut; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000235:genetics; D010375:Pedigree; D012042:Registries; D012208:Rhabdomyosarcoma / Q000235:genetics; D012306:Risk; D013736:Testicular Neoplasms / Q000235:genetics; D009396:Wilms Tumor / Q000235:genetics*