title: Disulfiram treatment of three patients with nickel dermatitis.
abstract: Diethyldithiocarbamate chelates nickel and accelerates its excretion in the urine. Disulfiram (Antabuse) splits into two molecules of sodium diethyldithiocarbamate after absorption. Oral administration of disulfiram tablets starting with 50 mg a day with a gradual increase in dosage to 100 mg more than than twice a day readily cleared the eczema in three patients with severe and long-standing nickel contact dermatitis.
mesh_terms: D000368:Aged; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000209:etiology; D004221:Disulfiram / Q000627:therapeutic use*; D004050:Ditiocarb / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*
chemical_list: D009532:Nickel; D004050:Ditiocarb; D004221:Disulfiram