Intracellular levels of cyclic nucleotides and proliferative activity of V79-1A cells.
We studied intracellular levels of cAMP and cGMP in relation to the proliferative activity of Chinese hamster V79-1A cells. In the course of population growth the intracellular level of cAMP correlated with cell growth activity. The intracellular level of cGMP rather correlated with population density. Stimulation of stationary cells with fresh medium was accompanied by a surge of cAMP level while cGMP level was not affected.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D007700:Kinetics; D008168:Lung
D000242:Cyclic AMP; D006152:Cyclic GMP