[Repair processes in wound tissues of experimental animals following administration of glycine].
A study was made of the effect of glycine given in doses approximating the physiological ones on the repair of processes in rat wound tissues. It was disclosed that in the early periods of wound healing, glycine administration leads to the increased content of cAMP and cAMP/cGMP ratio in the wound muscle and then in the granulation tissue, which appears to promote the intensification of the repair processes manifesting in the changes in tissue metabolism (DNA, collagen), in anti-inflammatory action, as well as in a more rapid maturation of the granulation tissue and wound reduction. It was also found that the doses of glycine tested do not affect the content of insulin and hydrocortisone in the blood of experimental animals.
D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis; D006152:Cyclic GMP / Q000096:biosynthesis; D005998:Glycine / Q000494:pharmacology*; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical; D014945:Wound Healing / Q000187:drug effects*
D007328:Insulin; D000242:Cyclic AMP; D006152:Cyclic GMP; D005998:Glycine; D006854:Hydrocortisone
Issledovanie reparativnykh protsessov v tkaniakh ran éksperimental'nykh zhivotnykh posle vvedeniia glitsina.