Effect of age on beta-adrenergic receptors on cerebral microvessels.
The responsiveness of beta-adrenergic receptors in cerebral microvessels was studied in aged rats by measuring cAMP formation induced by norepinephrine and [125I]iodohydroxybenzylpindolol binding. The density of beta-receptor sites is reduced by aging in the rat cerebral microvessels. These results suggest that the changes in brain circulation during aging may be at least partially due to a reduction of the beta-adrenergic control of cerebral microvessels.
D000375:Aging; D000818:Animals; D001921:Brain / Q000098:blood supply*; D000242:Cyclic AMP / Q000378:metabolism; D008297:Male; D008833:Microcirculation / Q000294:innervation; D009638:Norepinephrine / Q000494:pharmacology; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; C011878:iodohydroxybenzylpindolol; D010869:Pindolol; D000242:Cyclic AMP; D009638:Norepinephrine