[Controlled trial of isaxonine in traumatic or ischaemic (compression) neuropathies (author's transl)].
Fifty patients showing one or more impairments to large nerve trunks due to trauma or ischaemia received, after drawing lots, either isaxonine or a placebo. The evaluation criteria of the recovery were both clinical (testing of muscles, sensory disorders, vegetative disorders, tendon reflexes, tonicity, amyotrophy) and electrophysiological (electromyogram, conduction velocity, distal latency time, H reflex and H/M index). This study shows two major elements: the action of isaxonine shortens healing time (45-90 days instead of 120-150 days) and isaxonine allows neurological recovery to resume at neurologic level whereas the situation was dating back more than three months.
D002986:Clinical Trials as Topic; D004594:Electrophysiology; D006801:Humans; D009408:Nerve Compression Syndromes / Q000188:drug therapy*; D009416:Nerve Regeneration / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology; D011743:Pyrimidines / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000150:complications
D011743:Pyrimidines; C020375:isaxonine
Essai contrôlé de l'isaxonine dans les neuropathies de cuase traumatique ou ischémique (par compression).