Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities.
A bioactive form of enteroglucagon has been isolated from porcine jejuno-ileum according to its glucagon-like effect in liver. Enzymatic digestion followed by HPLC, dansylation and partial sequence analysis strongly suggests that this peptide contains the glucagon molecule (1--29) elongated at the C-terminal end by the octapeptide Lys-Arg-Asn-Lys-Asn-Ile-Ala-COOH and possibly modified in the N-terminal region. A specific action of bioactive enteroglucagon, increase in cAMP, has been found in the acid-secreting fundic part of the rat stomach. The term "oxyntomodulin" is therefore proposed to describe this peptide.
D000595:Amino Acid Sequence; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005748:Gastric Fundus / Q000187:drug effects / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005934:Glucagon; D004763:Glucagon-Like Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D007082:Ileum / Q000032:analysis*; D007583:Jejunum / Q000032:analysis*; D053772:Oxyntomodulin; D010446:Peptide Fragments / Q000302:isolation & purification; D051381:Rats; D013552:Swine
D005768:Gastrointestinal Hormones; D053772:Oxyntomodulin; D010446:Peptide Fragments; D004763:Glucagon-Like Peptides; D005934:Glucagon; D000242:Cyclic AMP