Inhibitory activity of cytosine arabinoside on Marek's disease virus.
The presence of ara-C in growth medium at concentrations of 10(-4) to 10(-7) M completely or partially suppressed the formation of plaques specific for MDV or HVT and decreased proportionally the growth of HPRS line 1 lymphoblastoid cells. Administration of ara-C to chickens immediately after infection with MDV (1 mg/chicken/day i.p. for 5 days) reduced the incidence of Marek's disease by 50%. Thus ara-C appears to be an inhibitor of Marek's disease.
D000818:Animals; D002460:Cell Line; D002645:Chickens; D003561:Cytarabine / Q000494:pharmacology* / Q000627:therapeutic use; D008381:Herpesvirus 2, Gallid / Q000187:drug effects / Q000502:physiology*; D008380:Marek Disease / Q000188:drug therapy; D010948:Viral Plaque Assay
D003561:Cytarabine