[Stimulation of cholinergic receptors and changes in cyclic nucleotide levels in the cerebral cortex of the guinea pig].
The effect of Atropine and Physostigmine on 3'5' AMP and 3'5' GMP content was investigated in slices of guinea-pig cerebral cortex maintained at rest or electrically-stimulated. Atropine and Physostigmine did not modify either the basal content or the electrically-evoked increase of 3'5' AMP and 3'5' GMP. On the contrary, Betanechol 25 micro M significantly increased 3'5' GMP and 3'5' AMP content in slices kept at rest. The effect was abolished by Atropine 1,5 x 10(-7) M and d-tubocurarine 7 x 10(-6) M, respectively.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001626:Bethanechol Compounds / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004558:Electric Stimulation; D006168:Guinea Pigs; D010830:Physostigmine / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000378:metabolism*; D014403:Tubocurarine / Q000494:pharmacology
D001626:Bethanechol Compounds; D011950:Receptors, Cholinergic; D001285:Atropine; D010830:Physostigmine; D000242:Cyclic AMP; D006152:Cyclic GMP; D014403:Tubocurarine
Stimolazione dei recttori colinergici e variazioni dei nucleotidi ciclici nella corteccia cerebrale di cavia.