title: Comparative in vitro activity of ceftizoxime, cefoperazone, and cefoxitin against anaerobic bacteria.
abstract: Against 482 obligate anaerobes studied by the agar dilution technique, ceftizoxime was significantly more active than both cefoxitin and cefoperazone (P less than 0.001); the latter two agents were comparable in activity. The enhanced activity of ceftizoxime, as compared with the activity of cefoxitin, was against both gram-positive and gram-negative anaerobes (especially Lactobacillus and bacteroides spp). Cefoperazone, however, was more active than cefoxitin against gram-positive anaerobes (particularly Lactobacillus spp.) but was less active than cefoxitin against gram-negative anaerobes (particularly Bacteroides fragilis and Veillonella spp.).
mesh_terms: D000693:Anaerobiosis; D001419:Bacteria / Q000187:drug effects*; D002438:Cefoperazone; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology; D015296:Ceftizoxime; D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D002511:Cephalosporins; D002440:Cefoxitin; D002438:Cefoperazone; D015296:Ceftizoxime; D002439:Cefotaxime