[Mechanism of action of cyproheptadine (peritol) on the hypothalamo-pituitary-adrenal axis].
The present paper is concerned with the mechanism of action of the blocker of serotonin receptors, cyproheptadine (peritol) on the hypothalamohypophyseal-adrenal system activity. It has been established in male rats that the inhibitory, antiserotonin action of peritol on the indicated system activity depends on the rate and rhythmicity of the drug administration, and, to a less degree, on its dosage. Peritol exerts a specific antiserotonin action via the CNS and by acting on some regulatory mechanism in peripheral tissues (adenylate cyclase system, corticosterone secretion).
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D000818:Animals; D003345:Corticosterone / Q000097:blood; D000242:Cyclic AMP / Q000378:metabolism; D003533:Cyproheptadine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000502:physiology; D014018:Tissue Distribution
D011985:Receptors, Serotonin; D003533:Cyproheptadine; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D003345:Corticosterone
Osobennosti mekhanizma deĭstviia tsiprogeptadina (peritola) na aktivnost' gipotalamo-gipofizarno-adrenalovoĭ sistemy.