[Effect of chronic administration of lithium chloride on the development of dopamine receptor sensitivity during morphine withdrawal in rats].
The morphine withdrawal syndrome was studied in male Wistar rats. Spontaneous aggressiveness, enhanced apomorphine aggressiveness, lowered pain threshold and decreased dopamine turnover were observed after withdrawal of 10-day treatment with the increasing doses of morphine (30-300 mg/kg). These changes attested to the increased sensitivity of dopamine receptors. Administration of morphine in conjunction with lithium chloride in a dose of 2 mekv/kg prevented the development of dopamine receptor hypersensitivity. Also, this method did not produce the increased spontaneous and apomorphine aggressiveness or the decreased dopamine turnover. Meanwhile the pain threshold remained lowered.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D006801:Humans; D008094:Lithium / Q000008:administration & dosage*; D018021:Lithium Chloride; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013997:Time Factors
D002712:Chlorides; D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D009020:Morphine; D008094:Lithium; D018021:Lithium Chloride; D004298:Dopamine; D006719:Homovanillic Acid
Vliianie khronicheskogo vvedeniia khlorida litiia na razvitie giperchuvstvitel'nosti dofaminovykh retseptorov pri otmene morfina u krys.