title: [Mezlocillin: a penicillin from the acylureido series. Synthesis and chemical properties].
abstract: Mezlocillin, 6-[D-2-(2-Oxo-3-mesyl-imidazolidine-1-carboxamido)- 2-phenylacetamido]-penicillanic acid, is a new semisynthetic acylureido-penicillin with a broad spectrum of antibacterial activity. The synthesis of mezlocillin from ampicillin and from 6-aminopenicillanic acid and the physicochemical properties are described. Mezlocillin is cleaved by penicillinase to the penicilloate which is degraded further by acids to the penilloate.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D008802:Mezlocillin; D010397:Penicillanic Acid / Q000032:analysis / Q000031:analogs & derivatives; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D010406:Penicillins; D010397:Penicillanic Acid; D010405:Penicillinase; D008802:Mezlocillin; C004408:aminopenicillanic acid
vernacular_title: Mezlocillin: Ein Penicillin aus der Acylureido-Reihe. Synthese und chemische Eigenschaften.