title: Demyelination induced in mice by avirulent Semliki Forest virus. I. Virology and effects on optic nerve.
abstract: Swiss A2G mice were infected intraperitoneally with an avirulent strain of Semliki Forest virus. The virus titres in the optic nerves, retina and brain were estimated on post-inoculation days 3 to 8. High titres of virus were obtained in the optic nerve, retina and brain. The optic nerves, retina and brain were studied by light microscopy up to post-inoculation day 67. Electron microscope studies wee carried out on the optic nerve on post-inoculation days 11 and 14. Inflammatory, microcystic changes and demyelination seen in the optic nerve were similar to those found in he central nervous system.
mesh_terms: D000818:Animals; D003711:Demyelinating Diseases / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D009900:Optic Nerve / Q000473:pathology*; D009902:Optic Neuritis / Q000473:pathology; D012672:Semliki forest virus / Q000472:pathogenicity*; D014036:Togaviridae Infections / Q000150:complications* / Q000382:microbiology