Enhanced immune reactivity to hepatoma 22a cells in MTV-infected compared with MTV-free C3H mice.
The transplantability and growth rate of mouse mammary and non-mammary tumours (sarcoma and hepatoma) were compared in MTV-free (MTV-) and MTV-infected (MTV+) C3H mice. It was demonstrated that sarcoma and hepatoma, in contrast to mammary tumours, grew better in MTV- mice. The difference between C3H sublines in the growth of hepatoma transplants was found to be determined by the stronger specific immune response and higher natural lymph node cell cytotoxicity in MTV+ mice.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis*; D003602:Cytotoxicity, Immunologic; D007111:Immunity, Cellular; D008114:Liver Neoplasms, Experimental / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology*; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000912:Antibodies, Neoplasm