Ultrastructural modifications of the erythrocyte membrane in Down's syndrome.
Spin label studies of erythrocyte membranes from patients with Down's syndrome showed no differences in the rigidity of membrane lipids with respect to normal subjects and a tendency for alterations in the state of membrane proteins. Electron microscopic studies demonstrated the occurrence of ultrastructural defects in membranes from trisomics which can be due to accelerated red cell aging as similar alterations were found in the fraction of oldest (most dense) cells in normal subjects.
D000293:Adolescent; D000328:Adult; D004314:Down Syndrome / Q000097:blood*; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000648:ultrastructure*; D004912:Erythrocytes / Q000648:ultrastructure*; D006801:Humans; D008563:Membrane Lipids / Q000097:blood; D008854:Microscopy, Electron; D012016:Reference Values
D008563:Membrane Lipids