title: Zeolithe A--A phosphate substitute for detergents: toxicological investigation.
abstract: Tests on Zeolithe A, a sodium aluminium silicate developed as a substitute for phosphates in detergents, were designed to investigate the safety of exposure to the material, or to detergents containing it, either under industrial conditions encountered during manufacturing processes or as a consequence of domestic use. The test programme included oral studies (acute, subchronic and long-term carcinogenicity tests and absorption measurements), and dermal, ocular and inhalation studies on the silicate alone and on appropriate detergent formulations, as well as studies of possible silicogenic activity and metal-complexing potential and measurements of dust generation and particle-size distribution. These studies did not produce any evidence to suggest that levels of domestic and industrial exposure resulting from the projected use of Zeolithe A in detergents would present any hazard to health. Zeolithe A did not induce silicotic tissue reactions and when incorporated into detergent formulations did not increase the liberation of fine dusts.
mesh_terms: D000284:Administration, Oral; D000538:Aluminum Silicates / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001774:Blood Chemical Analysis; D006224:Cricetinae; D003902:Detergents / Q000633:toxicity*; D004391:Dust; D005123:Eye / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007509:Irritants; D008297:Male; D008647:Mesocricetus; D051379:Mice; D010316:Particle Size; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012829:Silicosis / Q000209:etiology; D012882:Skin Tests; D013501:Surface-Active Agents / Q000633:toxicity*; D017641:Zeolites
chemical_list: D000538:Aluminum Silicates; D003902:Detergents; D004391:Dust; D007509:Irritants; D013501:Surface-Active Agents; D017641:Zeolites