A short transient increase in cyclic adenosine 3', 5'-monophosphate levels of neutrophil granulocytes following exposure to chemotactic factors.
Stimuli which are chemotactic for the retrospective neutrophils always produce a transient increase in cAMP within the first minute whereas the chemokinetic or other non-chemotactic stimuli tested have no such effect. The question as to whether the transient increase of cAMP levels plays any direct role in the transduction of a chemotactic stimulus cannot be answered. Restimulation experiments indicate that the extent of the cAMP response is not a reliable indicator for the chemotactic responsiveness of neutrophils; there is no quantitative correlation between these two parameters. Further detailed kinetic and quantitative studies of the cAMP system would be needed to clarify this point.
D002630:Chemotactic Factors / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D009504:Neutrophils / Q000502:physiology*; D013997:Time Factors
D002630:Chemotactic Factors; D000242:Cyclic AMP