[Inhibition of H2O2 and O2-. generation in the respiratory chain, treated with 2,3-dimercaptopropanol].
Inhibition of electron transport in bovine heart submitochondrial particles resulting from treatment with British antilewisite is accompanied by suppression of superoxide radical and H2O2 generation at the b-c1 site of the respiratory chain. In conjunction with the previously obtained data, the results suggest that the effect of British antilewisite is directed towards the step of ubihydroqinone oxidation to ubisemiquinone by the Rieske FeS-protein.
D000818:Animals; D002417:Cattle; D004112:Dimercaprol / Q000494:pharmacology*; D014450:Electron Transport Complex III; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007700:Kinetics; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D011808:Quinone Reductases / Q000378:metabolism; D013367:Submitochondrial Particles / Q000187:drug effects / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
D009097:Multienzyme Complexes; D004112:Dimercaprol; D013481:Superoxides; D006861:Hydrogen Peroxide; D011808:Quinone Reductases; D014450:Electron Transport Complex III; D010100:Oxygen
Podavlenie generatsii H2O2 i O2- . v dykhatel) noĭ tsepi, obrabotannoĭ 2,3-dimerkaptopropanolom.