[Changes in Na+, K+-adenosinetriphosphatase and 5'-nucleotidase activities in cell membrane isolated from rat liver after acute white phosphorus poisoning].
Na+, K+-ATPase and 5'-Nucleotidase activities in rat liver plasmamembranes after "in vivo" intoxication with a single dose of white phosphorus (10 mg/kg b.w. "per os") are investigated. Na+, K+-ATPase activity is significantly increased 1 hour and inhibited 12 hours after intoxication. 5'-Nucleotidase is strongly increased at 1, 2 and 4 hours after poisoning and is significantly decreased at 12 hours. The enhancement of both the enzymatic activities is evident prior to triglyceride accumulation in rat liver. Our results suggest that lipid fluidity of cell membrane is early and mildly affected during white phosphorus poisoning.
D015720:5'-Nucleotidase; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D009708:Nucleotidases / Q000378:metabolism*; D010758:Phosphorus / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D010758:Phosphorus; D009708:Nucleotidases; D015720:5'-Nucleotidase; D000254:Sodium-Potassium-Exchanging ATPase
Modificazioni dell'attivita' Na+, K+-adenosintrifosfatasica e 5'-nucleotidasica in plasmamembrane isolate da fegato di ratto in seguito alla intossicazione acuta con fosforo giallo.