title: A comparison of 3,4-diaminopyridine and 4-aminopyridine in the anaesthetized cat.
abstract: 3,4-Diaminopyridine and 4-aminopyridine were compared in the anaesthetized cat and found to be equiactive in their anti-curare activity. This in vivo similarity is at variance with previous in vitro studies which demonstrate 3,4-diaminopyridine to be more active than 4-aminopyridine at the neuromuscular junction. Possible reasons for the similarity between the two aminopyridines at the in vivo neuromuscular junction are discussed and it is concluded that 3,4-diaminopyridine has only marginal advantages over 4-aminopyridine as a potential anti-curare agent.
mesh_terms: D015761:4-Aminopyridine; D000077770:Amifampridine; D000631:Aminopyridines / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects*; D009541:Nictitating Membrane / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000631:Aminopyridines; D015761:4-Aminopyridine; D000077770:Amifampridine