An in vitro physiological study of normal and unstable human detrusor muscle.
A systematic in vitro physiological study of isolated human detrusor muscle strips is reported. Detrusor strips were obtained at operation. Pre-operative urodynamic studies enabled specimens to be classified as normal or unstable. Comparisons were made between responses of normal and unstable detrusor strips. The results provide evidence of a previously undescribed feedback-loop operating via pre-synaptic alpha-adrenoceptors which controls detrusor contractility. Further evidence is provided suggesting that an imbalance in this system is present in unstable detrusor muscle.
D000109:Acetylcholine / Q000494:pharmacology; D000328:Adult; D000368:Aged; D003000:Clonidine / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology; D010646:Phentolamine / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects / Q000503:physiopathology*
D011942:Receptors, Adrenergic, alpha; D007545:Isoproterenol; D003000:Clonidine; D000109:Acetylcholine; D010646:Phentolamine