Involvement of endogenous digitalis-like substance in genesis of deoxycorticosterone-salt hypertension.
In an attempt to evaluate the role of endogenous digitalis-like substance in the genesis of deoxycorticosterone (DOCA) -salt hypertension, the effects of intravenous anti-digoxin antibody on the blood pressure response were observed in male Wistar rats that underwent heminephrectomy followed by treatment with DOCA and saline. Administration of anti-digoxin antibody caused a marked decrease in the blood pressure which continued for about an hour. Such a change in the blood pressure was not observed in pertinent control animals. Thus, it seems that endogenous digitalis-like substance plays an important role in the genesis of DOCA-salt hypertension.
D000818:Animals; D003900:Desoxycorticosterone; D004071:Digitalis Glycosides / Q000378:metabolism*; D004077:Digoxin / Q000037:antagonists & inhibitors; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D004071:Digitalis Glycosides; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase