Persistent reactivable latent herpes simplex virus infection in trigeminal ganglia of mice treated with antiviral drugs.
Latent reactivable infection was established with HSV in mouse trigeminal ganglion. A number of antiviral drugs (IUDR, acycloguanosine, Ara-A, PAA and PFA), effective against acute CNS infection with HSV, failed to influence the latent infection once established. Neither lipophilic properties of PFA-derivatives nor the combination of Ara-A and acycloguanosine improved the drug-effects on HSV latency.
D000212:Acyclovir; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D017245:Foscarnet; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006561:Herpes Simplex / Q000188:drug therapy / Q000382:microbiology*; D007065:Idoxuridine / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D018139:Simplexvirus / Q000254:growth & development*; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014276:Trigeminal Nerve / Q000382:microbiology*; D014740:Vidarabine / Q000627:therapeutic use; D014779:Virus Replication
D000998:Antiviral Agents; D017245:Foscarnet; D006147:Guanine; D014740:Vidarabine; D007065:Idoxuridine; D010746:Phosphonoacetic Acid; D000212:Acyclovir