Dopaminergic mechanism in generalized photosensitive epilepsy.
Apomorphine, a dopamine receptor agonist, blocked epileptic photosensitivity in patients with primary corticoreticular epilepsy. This effect was not modified by naloxone, a narcotic antagonist, suggesting that apomorphine acts on cerebral dopaminergic receptors. Apomorphine did not block spontaneous spike-and-wave discharges in patients with nonphotosensitive primary corticoreticular epilepsy. The different actions of apomorphine on spontaneous and photically induced spike-and-wave activity suggest that there is a selective dopaminergic mechanism in human epileptic photosensitivity.
D000293:Adolescent; D000328:Adult; D001058:Apomorphine / Q000627:therapeutic use; D004298:Dopamine / Q000502:physiology*; D004594:Electrophysiology; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D010775:Photic Stimulation / Q000009:adverse effects*; D011954:Receptors, Dopamine / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects
D011954:Receptors, Dopamine; D011957:Receptors, Opioid; D009270:Naloxone; D001058:Apomorphine; D004298:Dopamine