Biological chelation: 2,3-dimercapto-propanesulfonic acid and meso-dimercaptosuccinic acid.
Water soluble analogs of British Anti-Lewisite that are active orally and less toxic than BAL are now available. These agents are 2,3-dimercapto-1-propanesulfonic acid and meso-dimercaptosuccinic acid. Evidence for their effectiveness in preventing the lethal effects of sodium arsenite in mice and lewisite in rabbits is presented. These analogs can be expected to replace BAL in the treatment of heavy metal poisoning.
D000818:Animals; D020261:Arsenic Poisoning; D018053:Arsenites; D002105:Cadmium Poisoning; D002614:Chelating Agents / Q000494:pharmacology*; D004112:Dimercaprol / Q000031:analogs & derivatives* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology; D017670:Sodium Compounds; D004113:Succimer / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D014494:Unithiol / Q000494:pharmacology*
D018053:Arsenites; D002614:Chelating Agents; D017670:Sodium Compounds; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D014494:Unithiol; C017947:sodium arsenite; C010005:N-acetylpenicillamine; D004113:Succimer; D010396:Penicillamine