title: Intranasal vaccine trial for canine infectious tracheobronchitis (kennel cough).
abstract: Two field trials were conducted during periods of endemic (summer) and epizootic (winter) canine infectious tracheobronchitis activity to evaluate the efficacy of three intranasal vaccines in a closed commercial beagle breeding kennel. A trivalent vaccine containing Bordetella bronchiseptica, canine parainfluenza, and canine adenovirus-2 was administered at 3 weeks of age. The vaccine was 71.2% and 81.8% effective in decreasing the incidence of coughing during the winter and summer trials, respectively. The number of deaths was lower in each of the vaccine groups than in the placebo groups. No adverse reactions were observed with any of the intranasal vaccines.
mesh_terms: D000256:Adenoviridae / Q000276:immunology; D000281:Administration, Intranasal; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage; D001884:Bordetella / Q000276:immunology; D001991:Bronchitis / Q000517:prevention & control / Q000662:veterinary*; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D018108:Respirovirus / Q000276:immunology; D012621:Seasons; D014136:Tracheitis / Q000517:prevention & control / Q000662:veterinary*; D014612:Vaccines / Q000008:administration & dosage*; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D001428:Bacterial Vaccines; D014612:Vaccines; D014765:Viral Vaccines