Clinical and epidemiological features of adenovirus keratoconjunctivitis in London.
Ninety-eight patients were studied. Ninety were consecutive patients who were isolation-positive for adenovirus, and 8, who were associated with a hospital outbreak of adenovirus serotype 8 infection, developed characteristic features of infection but were isolation-negative. The ratio of males to females was 2 to 1, and most patients were aged 20 to 39. Adenovirus serotypes 3, 7, and 8 were isolated from 86% of patients, and serotypes 2, 4, 5, 11, 15, and 15/29 from the remaining 14%. Adenovirus serotype 7 was more commonly isolated from patients under the age of 19 and was Not isolated during winter. Sources of infection could be identified in 36% of patients and included contact with upper respiratory tract of ocular infections, a hospital outbreak, and a recent visit to a swimming pool. Associated systemic disease was detected in 47% of patients, most of whom had upper respiratory tract infection. The most severe and prolonged conjunctivitis was caused by serotypes 5 and 8. Most patients developed epithelial punctate keratitis. Subepithelial punctate keratitis, which was once-considered to be a characteristic feature of adenovirus serotype 8, developed in cases of serotype 3, 4, 5, 7, and 8 infection.
D000257:Adenoviridae Infections / Q000453:epidemiology*; D000258:Adenovirus Infections, Human / Q000453:epidemiology*; D000260:Adenoviruses, Human / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D002648:Child; D003428:Cross Infection / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007637:Keratoconjunctivitis / Q000453:epidemiology* / Q000209:etiology; D008131:London; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000150:complications; D012621:Seasons; D012703:Serotyping; D014605:Uveitis / Q000209:etiology