Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.
A normal human gene homologous to the p21 ras oncogene of Harvey murine sarcoma virus induced oncogenic transformation and high p21 ras levels in murine fibroblasts when this gene was ligated to a control element (the long terminal repeat) from a murine or feline retrovirus. These results indicate that high levels of a gene product encoded by a normal human oncogene can induce tumorigenic transformation.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004262:DNA Restriction Enzymes; D004274:DNA, Recombinant; D005796:Genes; D005814:Genes, Viral; D006801:Humans; D007708:Kirsten murine sarcoma virus / Q000235:genetics; D051379:Mice; D009693:Nucleic Acid Hybridization; D051381:Rats; D009053:Sarcoma Viruses, Murine / Q000235:genetics*; D013045:Species Specificity
D004274:DNA, Recombinant; D004262:DNA Restriction Enzymes