Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat.
1 Dexamethasone and hydrocortisone induced the release of anti-phospholipase proteins into the peritoneal cavities of rats. 2 Adrenocorticotrophic hormone (ACTH) also releases these proteins in normal but not in adrenalectomized rats. 3 Peritoneal lavage proteins were separated by ion-exchange and size exclusion chromatography. The anti-phospholipase activity occurred in four separate fractions with the major component having an apparent mol. wt. of 40 k. 4 Column fractions containing these anti-phospholipase proteins had anti-inflammatory effects in the rat carrageenin pleurisy model whereas other fractions were inactive. 5 The proteins appear to be identical to macrocortin and lipomodulin, the 'second messengers' of glucocorticoid hormone action on the arachidonate system.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D005938:Glucocorticoids / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D010529:Peritoneal Cavity / Q000378:metabolism; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D011506:Proteins / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000494:pharmacology
D005938:Glucocorticoids; D011506:Proteins; D014020:Tissue Extracts; D000324:Adrenocorticotropic Hormone; D010740:Phospholipases; D010741:Phospholipases A