Conformational stability of alternating d (CG) oligomers in high salt solution.
The conformation of d (CG)n oligomers with n = 2,3 has been studied in aqueous solution in the presence of high salt concentration. A minimum n value of three is necessary to obtain a left-handed Z-helix. When d (CG)3 is flanked by three non Z-helicogenic alternating AT sequences the left-handed helix is unstable and a B-type conformation is obtained also at high salt concentration.
D002712:Chlorides; D002942:Circular Dichroism; D003839:Deoxyadenosines; D003841:Deoxycytidine; D003849:Deoxyguanosine; D004355:Drug Stability; D008094:Lithium; D018021:Lithium Chloride; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D009994:Osmolar Concentration; D012965:Sodium Chloride; D013936:Thymidine
D002712:Chlorides; D003839:Deoxyadenosines; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D003841:Deoxycytidine; D012965:Sodium Chloride; D008094:Lithium; D018021:Lithium Chloride; D003849:Deoxyguanosine; D013936:Thymidine