title: Increased excitability of hippocampal unmyelinated fibres following conditioning stimulation.
abstract: Unmyelinated fibres in the stratum radiatum (area CA1) were electrically stimulated in hippocampal slices from guinea pigs. The size of the evoked fibre volley was increased by a preceding conditioning stimulation to the same fibres, provided that the strength of the conditioning stimulus was larger than that of the test pulse. This facilitation was maximal for 20-30 ms interstimulus intervals and had a duration of about 200 ms. The results are compatible with an increased excitability (reduction in threshold) specific for fibres activated by the conditioning stimulation.
mesh_terms: D000818:Animals; D046508:Culture Techniques; D004558:Electric Stimulation; D006168:Guinea Pigs; D006624:Hippocampus / Q000502:physiology*; D009412:Nerve Fibers / Q000502:physiology*; D009473:Neuronal Plasticity; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission