Hepatitis B and A virus antibodies in alcoholic steatosis and cirrhosis.
Sera from 74 alcoholics with cirrhosis and 63 alcoholics with steatosis were tested for antibody to hepatitis B surface antigen, to hepatitis B core antigen, and to hepatitis A virus by radioimmunoassay or enzyme-linked immunosorbent assay. No significant difference between the two groups of alcoholics could be found concerning the prevalence of these antibodies. The total group of patients had antibody to hepatitis B surface antigen or hepatitis B core antigen, or both, significantly (p less than 0.001) more often (26%) than sex- and age-matched controls (4%). No significant difference was found between patients and controls concerning the prevalence of antibody to hepatitis A virus (46% v 40%). In patients with cirrhosis, no correlation between wedged hepatic vein pressure or wedged-to-free hepatic vein pressure and any of the viral antibodies could be established. The present results suggest that hepatitis B virus does not play a major role in the progression of alcoholic liver disease, but longitudinal studies are needed to solve this problem. The reason for the increased prevalence of antibodies to hepatitis B virus in these patients is unknown.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D005235:Fatty Liver, Alcoholic / Q000276:immunology*; D005260:Female; D006503:Hepatic Veins / Q000503:physiopathology; D035922:Hepatitis A Antibodies; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006507:Hepatovirus; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014690:Venous Pressure
D000914:Antibodies, Viral; D035922:Hepatitis A Antibodies; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens