Isolation and characterisation of toxic components from the venom of the common Indian sea snake (Enhydrina schistosa).
Three neurotoxic components, enhydrotoxins a, b and c, were isolated by a three step procedure from the venom of the sea snake Enhydrina schistosa, caught in the Arabian sea. The i.v. LD50 values in mice were 0.042, 0.045 and 0.052 mg/kg, respectively. All three toxins irreversibly blocked neuromuscular transmission. Abolition of responses to acetylcholine indicated a post-synaptic site of action of these toxins. The molecular weight and amino acid composition of enhydrotoxin a are similar to values earlier reported for Enhydrina toxins.
D000818:Animals; D002645:Chickens; D004546:Elapid Venoms / Q000032:analysis*; D051379:Mice; D011506:Proteins / Q000032:analysis; D009435:Synaptic Transmission / Q000187:drug effects; D014118:Toxins, Biological / Q000032:analysis* / Q000633:toxicity
D004546:Elapid Venoms; D011506:Proteins; D014118:Toxins, Biological