title: Urinary excretion and circadian rhythm of cyclic-AMP and cyclic-GMP in childhood.
abstract: Normal urine values of cyclic-AMP and cyclic-GMP were determined in healthy children, using a competitive protein binding and a radioimmunoassay technique respectively. Neither sex nor age affected the cyclic nucleotides excretion. A circadian rhythm in the urinary excretion of cyclic-AMP was observed throughout a 20 h period. The peak excretion occurred at 16.00 h, while minimal excretion was at 24.00 h. The differences observed between the periods of highest and lowest excretion of cyclic-GMP were not statistically significant.
mesh_terms: D001667:Binding, Competitive; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D000242:Cyclic AMP / Q000652:urine*; D006152:Cyclic GMP / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D011863:Radioimmunoassay
chemical_list: D000242:Cyclic AMP; D006152:Cyclic GMP