Modification of the sensitivity of CHO cells to mitomycin C by dibutyryl cyclic AMP.
The survival of CHO cells exposed to mitomycin C was decreased three times that of the cells treated with 1 mM dibutyryl cyclic AMP before mitomycin C treatment, as compared to the absence of treatment with this cyclic nucleotide. The sensitization effect began at 3-4 hours after the start of pre-treatment, reached a maximum at around 10 hours and continued to be effective. Post-treatment with the cyclic nucleotide for more than 12 hours increased the survival of CHO cells exposed to mitomycin C.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects*
D008937:Mitomycins; D016685:Mitomycin; D003994:Bucladesine