Experimental parainfluenzavirus infection in mice: fatal illness with atrophy of thymus and spleen in mice caused by a variant of parainfluenza 3 virus.
Intracerebral inoculation of the YN strain of parainfluenza 3 virus was found to induce an acute fatal illness characterized by marked thymic and splenic atrophy in newborn mice. Previously we showed that the YN strain contains three distinct plaque-type variants, LT, SC, and M. Of these, the M-type variant induced this fatal illness, whereas the other two variants induced hydrocephalus.
D000818:Animals; D000831:Animals, Newborn; D001284:Atrophy; D014644:Genetic Variation; D051379:Mice; D010224:Parainfluenza Virus 3, Human / Q000254:growth & development / Q000472:pathogenicity*; D018184:Paramyxoviridae Infections / Q000473:pathology*; D018108:Respirovirus / Q000472:pathogenicity*; D013154:Spleen / Q000473:pathology*; D013950:Thymus Gland / Q000473:pathology*; D010948:Viral Plaque Assay