Latency of herpes simplex virus in ocular tissue of mice.
At 5 to 7 months after corneal inoculation of herpes simplex virus type 1 in mice, explants of ocular tissue yielded virus. Immunoperoxidase study of explants undergoing reactivation revealed herpes simplex virus antigens in retinal tissue. These results indicate that herpes simplex virus can establish and maintain latency in ocular tissue, most probably in the retina.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D046508:Culture Techniques; D005123:Eye / Q000382:microbiology*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D012160:Retina / Q000276:immunology / Q000382:microbiology*; D018139:Simplexvirus / Q000276:immunology / Q000502:physiology*; D012668:Trigeminal Ganglion / Q000382:microbiology
D000956:Antigens, Viral