[Selectivity of the channels formed by flavomycoin in a lipid bilayer as a function of the concentrations of transported ions].
Experiments on selective properties of the flavomycoin channels in a lipid bilayer in the solution of KCl show that the permeability ratio PCl/PK decreased with KCl concentration. A mathematical model of ion transport is developed which provides a quantitative description of the observed nonmonotonic dependence of transmembrane potential at a zero current on the concentration of KCl. An increase in PK relative to PCl is due to the difference in location of the binding sites of K+ and Cl- in a channel. The binding sites of Cl- are closer to the channel mouth as compared with those of K+.
D000900:Anti-Bacterial Agents; D007473:Ion Channels / Q000502:physiology; D008051:Lipid Bilayers; D008433:Mathematics; D008954:Models, Biological; D010539:Permeability; D011090:Polyenes; D011189:Potassium Chloride
D000900:Anti-Bacterial Agents; D007473:Ion Channels; D008051:Lipid Bilayers; D011090:Polyenes; C030620:flavomycoin; D011189:Potassium Chloride
Zavisimost' selektivnosti kanalov, obrazovannykh flamikoinom v lipidnom bisloe, ot kontsentratsii perenosimykh ionov.