title: Agonistic behaviour in rats: evidence for non-involvement of opioid mechanisms.
abstract: It has recently been proposed that a stress-activated, endogenous analgesia mechanism would be adaptive in situations in which pain perception might otherwise disrupt effective behavioural performance. In a semi-natural test situation, the current study examined two predictions arising from this hypothesis: (1) in a manner analogous to other stressors, agonistic experience should produce analgesia and, if naloxone-sensitive opioid mechanisms are implicated, then (2) pretreatment with naloxone should block the development of this response and alter the displayed behaviour patterns. Neither prediction was substantiated by the data. Experience of an agonistic encounter failed to produce analgesia in either resident or intruder animals. Furthermore, naloxone hydrochloride (1-25 mg/kg) was also without effect on patterns of offense or defense. Data are discussed in relation to the critical nature of the stimulus factors involved in the activation of endogenous analgesic mechanisms and the postulated involvement of such mechanisms in biologically-adaptive behaviours.
mesh_terms: D000374:Aggression / Q000502:physiology*; D000378:Agonistic Behavior / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D004723:Endorphins / Q000502:physiology*; D006801:Humans; D008297:Male; D009115:Muridae; D009270:Naloxone / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D011957:Receptors, Opioid / Q000187:drug effects
chemical_list: D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone