Beta adrenergic receptors in pigmented ciliary processes.
Beta adrenergic receptors from membrane fragments of pigmented sheep eyes were studied and characterised by ligand binding techniques after the removal of melanin. In a representative experiment the beta max (total number of beta receptors) was 394.9 fmol/mg protein. The receptor affinity (Ka) was 440 pM. The potency series of drugs to displace 125I-HYP from the receptors was timolol  = (-) propranolol greater than (+) propranolol greater than salbutamol greater than practolol. beta 1 Receptors were not detected in the ciliary processes. beta 2 Receptors were the prominent adrenergic receptors present. The theory as to how beta blockers work in glaucoma, their site of action, and the potential role of beta 2 blockers for use in intraocular pressure control is discussed.
D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002924:Ciliary Body / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010858:Pigmentation; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011217:Practolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism*; D012756:Sheep; D013999:Timolol / Q000494:pharmacology
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; C011878:iodohydroxybenzylpindolol; D013999:Timolol; D011433:Propranolol; D010869:Pindolol; D000420:Albuterol; D011217:Practolol