Retinoid-induced growth inhibition of herpesvirus-transformed marmoset lymphoblastoid cell lines.
The in vitro proliferation of herpesvirus-transformed marmoset lymphoblastoid cell lines (LCL) was inhibited by retinoic acid and retinyl acetate. Both Herpesvirus-ateles-and Herpesvirus-saimiri-transformed LCL with T-cell characteristics and Epstein-Barr-transformed LCL with B-cell markers were more sensitive to retinoic acid than to retinyl acetate. Inhibition of LCL proliferation was dependent on retinoid concentration and became apparent only after 3-4 days of exposure. In vitro assays for marmoset LCL sensitivity to retinoids may indicate the potential usefulness of these compounds in the chemoprevention of virus-induced lymphoma in vivo.
D000818:Animals; D002143:Callitrichinae; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival; D002472:Cell Transformation, Viral / Q000187:drug effects*; D004224:Diterpenes; D006564:Herpesviridae; D004854:Herpesvirus 4, Human; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D000084562:Retinyl Esters; D014212:Tretinoin / Q000494:pharmacology*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D014212:Tretinoin