title: Choroid plexus, brain and kidney Na+,K+-ATPase: comparative activities in fetal, newborn and young adult rabbits.
abstract: We have studied maturation of brain barrier systems in fetal, newborn, juvenile and adult rabbits. We have compared choroid plexus and brain Na+,K+-ATPase levels in each age group, as well as serum and CSF Na+ concentration as a measure of the ability of the choroid plexus to generate a gradient from blood to CSF. The choroid plexus appears functionally mature at all ages studied, both in ability to produce a Na+ gradient and in ATPase levels. In contrast, brain ATPase levels rose markedly with age. Kidney ATPase measured for comparison showed a pattern similar to brain.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001812:Blood-Brain Barrier; D001921:Brain / Q000201:enzymology*; D002831:Choroid Plexus / Q000201:enzymology*; D005260:Female; D005333:Fetus; D007668:Kidney / Q000201:enzymology*; D011247:Pregnancy; D011817:Rabbits; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase