A note on synthesis and reactivity towards DNA of glycidonitrile, the epoxide of acrylonitrile.
Different ways have been used to synthesize glycidonitrile, the epoxide of acrylonitrile. The reaction product has been characterized by n.m.r. spectroscopy. While glycidonitrile-induced strand breaks in SV40 phage DNA in vitro, acrylonitrile did not.
D000181:Acrylonitrile / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects; D004279:DNA, Viral / Q000235:genetics*; D004852:Epoxy Compounds; D005027:Ethylene Oxide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009570:Nitriles / Q000494:pharmacology; D013539:Simian virus 40 / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
D004279:DNA, Viral; D004852:Epoxy Compounds; D009570:Nitriles; C033154:2-cyanoethylene oxide; D005027:Ethylene Oxide; D000181:Acrylonitrile