Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23).
A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.
D018288:Carcinoma, Small Cell / Q000235:genetics*; D002478:Cells, Cultured; D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3; D006801:Humans; D007621:Karyotyping; D008175:Lung Neoplasms / Q000235:genetics*