Selective stimulation of PGE1-synthesis by soterenol in the isolated rat vas deferens is mediated by alpha adrenoreceptors.
The effects of soterenol on prostaglandin (PG) release by the isolated rat vas deferens were studied. Soterenol increased the amount of PGE1 released into the medium without affecting that of PGE2 or PGF2 alpha. The effect of soterenol was inhibited by phentolamine but not by butoxamine. It is concluded that soterenol elicits the release of PGE1 by the isolated rat vas deferens via stimulation of alpha adrenoreceptors.
D000818:Animals; D002078:Butoxamine / Q000494:pharmacology; D015232:Dinoprostone; D004983:Ethanolamines / Q000494:pharmacology*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D014649:Vas Deferens / Q000378:metabolism*
D004983:Ethanolamines; D011458:Prostaglandins E; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D002078:Butoxamine; C100252:soterenol; D015232:Dinoprostone; D010646:Phentolamine