title: [Cyclic nucleotides (cAMP and cGMP) in the dog plasma during extracorporeal hemocarboperfusion].
abstract: The concentrations of cyclic nucleotides (cAMP and cGMP) were measured in blood plasma of dogs subjected to extracorporeal hemocarboperfusion. In spite of complete and irreversible absorption of cyclic nucleotides by the coal absorbent, SKN-2M, the concentration of cGMP in plasma remained within normal. The concentration of cAMP increased 1.5-2.5-fold. The rise in the cAMP concentration was not connected with injection of sodium thiopental and heparin before hemocarboperfusion. It is assumed that cyclic nucleotides play the role of circulating intercellular regulators in blood plasma. These regulators are necessary for the normal course of metabolic processes.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D004285:Dogs; D006464:Hemoperfusion / Q000379:methods*; D006493:Heparin / Q000494:pharmacology; D008297:Male; D013874:Thiopental / Q000494:pharmacology
chemical_list: D006493:Heparin; D000242:Cyclic AMP; D006152:Cyclic GMP; D013874:Thiopental
vernacular_title: Tsiklicheskie nukleotidy (tsAMF i tsGMF) v plazme krovi sobak pri ékstracorporal'noĭ gemokarboperfuzii.