title: Fate of human corticotrophin immediately after intravenous administration to the rat.
abstract: The distribution and degradation of tritium-labelled human 1-39 corticotrophin have been studied after intravenous administration to the rat. Within 5 min of injection of single major metabolite, 3-39 corticotrophin, appears in the circulation. This metabolite, however, has only 3.6% of the steroidogenic potency of 1-39 corticotrophin and the evidence suggests that it is formed in muscle and skin. By 5 min, extensive degradation had occurred in all the major tissues in the body (muscle, skin, liver, kidney, gut).
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000818:Animals; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism; D014018:Tissue Distribution; D014316:Tritium
chemical_list: D014316:Tritium; D000324:Adrenocorticotropic Hormone