Variation in cellular tropism between isolates of equine herpesvirus-1 in foals.
Subtype-1 isolates of Equine herpesvirus-1 (EHV-1) from a quadriplegic horse and from an aborted foetus were compared with each other and with a subtype-2 respiratory isolate. All 3 isolates were detected in the epithelium and macrophages of the respiratory tract. Both the paresis and foetal subtype-1 isolates replicated in the epithelium of the ileum and this correlated with the recovery of virus from faeces in vivo. The paresis subtype-1 isolate also had a predelection for vascular endothelial cells, particularly in the nasal mucosa, but also in the lungs, central nervous system, adrenal and thyroid. In the 9 foals inoculated with the paresis isolate two developed hind limb dysfunction, four developed diarrhoea, and one of these 4 died with an intussusception. The differences between these isolates are discussed in relation to other herpesviruses.
D000818:Animals; D000956:Antigens, Viral; D002478:Cells, Cultured; D004848:Epithelium / Q000382:microbiology; D006564:Herpesviridae / Q000502:physiology*; D004861:Herpesvirus 1, Equid / Q000254:growth & development / Q000302:isolation & purification / Q000502:physiology*; D006736:Horses / Q000382:microbiology*; D008264:Macrophages / Q000382:microbiology*; D010291:Paresis / Q000209:etiology; D011817:Rabbits; D014779:Virus Replication
D000956:Antigens, Viral