Effects of various replacement oestrogens on hepatic transcortin synthesis in climacteric women.
The influence of peri-menopausal oestrogen replacement therapy upon protein synthesis in the liver was investigated. Changes in the cortisol-binding capacity of transcortin (TC-BC) were utilized as an indicator of hepatic oestrogen sensitivity. Forty-two climacteric women were studied before and after treatment with various drugs at different doses (patients receiving identical compounds served as their own controls for the evaluation of dosage effects; duration of medication: 14 days at each dose). Oral administration of oestriol (1 and 2 mg daily; n = 6), oestriol (1 and 2 mg daily) + oestradiol-17 beta (2 and 4 mg daily; n = 8), oestradiol valerate (1, 2, 4 and 6 mg daily; n = 6), conjugated equine oestrogens (0.3 and 0.6 mg daily; n = 6), sodium oestrone sulphate (0.8 and 1.6 mg daily) + sodium equilin sulphate (0.2 and 0.4 mg daily; n = 6) and quinoestrol (25 micrograms daily; n = 6) failed to alter TC-BC. However, ingestion of higher doses of conjugated equine oestrogens (0.9 and 1.25 mg daily; n = 5) and quinoestrol (50 micrograms daily; n = 6) caused a significant rise (P less than 0.01). Ethinyloestradiol was given orally as a reference substance and elicited an elevation of expected magnitude. Vaginal administration of dienoestrol cream (1 mg daily; n = 4) did not change TC-BC. These data indicate that the hepatotrophic effects of replacement oestrogens vary depending on the preparation and dosage selected for treatment.
D002979:Climacteric; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004966:Estrogens, Conjugated (USP); D004970:Estrone / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008593:Menopause; D008875:Middle Aged; D011446:Prospective Studies; D011800:Quinestrol / Q000494:pharmacology; D014156:Transcortin / Q000096:biosynthesis*
D004966:Estrogens, Conjugated (USP); D004970:Estrone; D004997:Ethinyl Estradiol; D004958:Estradiol; D014156:Transcortin; D004964:Estriol; D011800:Quinestrol