Anti-inflammatory steroids without pituitary-adrenal suppression.
When two new steroids, methyl prednisolonate and methyl 20-dihydroprednisolonate, were applied locally their anti-inflammatory activities were nearly equivalent to those of the parent compound prednisolone in the cotton pellet granuloma bioassay. However, when these two derivatives were administered systemically, their anti-inflammatory activities were weaker than those of the parent compound. Furthermore, unlike the parent compound, these new anti-inflammatory steroids did not suppress pituitary-adrenal function or cause liver glycogen depletion in rats.
D000287:Administration, Topical; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood; D008112:Liver Glycogen / Q000096:biosynthesis; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats
D000893:Anti-Inflammatory Agents; D008112:Liver Glycogen; C025429:methyl prednisolonate; C025428:methyl 20-dihydroprednisolonate; D000324:Adrenocorticotropic Hormone; D011239:Prednisolone; D003345:Corticosterone