Polypeptide hormones and the prostate.
Results presented in this paper demonstrate that both insulin and prolactin have direct effects on the growth and functions of prostatic epithelium. They also act on the prostate indirectly by potentiating the effects of testosterone on these cells. Both are capable of inducing cell multiplication and increasing the activity of ornithine decarboxylase in cells. However, the intracellular events which follow the interaction of these hormones with the cell membrane receptors are not clearly understood. Little is known at the present time about the specific effects of insulin and prolactin on prostatic growth regulation and function and about their interactions with other protein and steroid hormones. A considerable amount of further research is needed to establish the basic influences of insulin and prolactin on the prostate. This inquiry is essential before the role of these hormones in normal and abnormal growth of the prostate can be understood.
D000375:Aging; D000818:Animals; D004848:Epithelium / Q000502:physiology; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology; D008297:Male; D008321:Mammary Glands, Animal / Q000166:cytology; D009374:Neoplasms, Experimental / Q000503:physiopathology; D011388:Prolactin / Q000502:physiology; D011467:Prostate / Q000378:metabolism / Q000502:physiology*; D011471:Prostatic Neoplasms / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000378:metabolism; D011981:Receptors, Prolactin; D013045:Species Specificity; D013737:Testis / Q000502:physiology
D004967:Estrogens; D006728:Hormones; D007328:Insulin; D011956:Receptors, Cell Surface; D011981:Receptors, Prolactin; D011388:Prolactin