title: Iodine-induced hypothyroidism and goiter following lipiodolTM lymphography.
abstract: Hypothyroid goiter is a rare but well recognized complication following long term administration of iodine containing expectorants and disinfectants in children. Only few reports exist on iodine-induced hypothyroidism after a single injection of the iodized radiopaque dye Lipiodol. A 15-year-old boy with previously normal thyroid function is described who developed hypothyroid goiter within six weeks following bipedal lymphography. Urinary iodine excretion was extremely elevated up to 18 mg/day while serum concentrations of total thyroxine were below the euthyroid range and thyrotropin levels were elevated. After oral L-thyroxine treatment the goiter disappeared. Thyroid function remained normal when treatment was discontinued after five months although iodine excretion was still 50 times higher (2.5 mg/day) than in normal age matched children. The observed alterations of the thyroid gland were caused by a long lasting Wolff-Chaikoff effect with a delayed adaptation to high iodide concentrations.
mesh_terms: D000293:Adolescent; D006042:Goiter / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy; D007459:Iodized Oil / Q000009:adverse effects*; D008220:Lymphography / Q000009:adverse effects; D008297:Male; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D007459:Iodized Oil; D013974:Thyroxine