A note on dysenzymia in the liver of rats fed on zinc, an essential metal.
Although zinc in traces is essential for the growth and well being of the animal, however a long-term treatment has been found equally toxic to the liver and kidney. Present report describes its effects on few key enzymes viz. alkaline phosphatase, acid phosphatase, 5-nucleotidase, lipase, glucose-6-phosphatase, and cholinesterase in the liver of rat, Rattus rattus albino. Histochemical observations have provided visual evidences on Zn-induced dysenzymia. The results have further been interpreted in terms of its effects on cellular organelle, levels of enzyme protein and microenvironment of the hepatic parenchyma.
D000085:Acetates / Q000008:administration & dosage; D019342:Acetic Acid; D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002802:Cholinesterases / Q000378:metabolism; D004032:Diet; D004950:Esterases / Q000378:metabolism*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009708:Nucleotidases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
D000085:Acetates; D004950:Esterases; D008049:Lipase; D002802:Cholinesterases; D009708:Nucleotidases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; C030287:nucleotidase; D005952:Glucose-6-Phosphatase; D015032:Zinc; D019342:Acetic Acid