Influence of lead and nickel on passive cutaneous anaphylaxis in the rat.
Male rats, IOPS OFA strains, were injected s.c. with doses of lead acetate (0.5 to 30 mg Pb2+/kg/day) and nickel chloride (0.05 to 5 mg Ni2+/kg/day), for 3 days prior to being challenged for immediate hypersensitivity induced by ovalbumin/antiovalbumin system. The vascular permeability was statistically increased in animals of each group (P less than 0.001, Student's t-test). These results may indicate an action of lead and nickel salts on mast cells and their membranes, but also an action on the vasodilation induced by vasoactive amines.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001886:Bordetella pertussis / Q000276:immunology; D002463:Cell Membrane Permeability / Q000187:drug effects; D007854:Lead / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D009532:Nickel / Q000494:pharmacology*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats
D007854:Lead; D009532:Nickel