title: [Hematotoxicity of thiamphenicol. Report of two cases of acute erythroblastopenia (author's transl)].
abstract: Thiamphenicol is known to produce two hematological side effects: a decrease in blood cell count concerning mainly red blood cells; in this case regression is observed after withdrawal of the drug; the frequency of this side effect appears to be higher than that observed after chloramphenicol administration. Severe and sometimes fatal pancytopenia is rare and related to primary bone marrow failure; its incidence seems to be increased by high dosages, long-term or repeated administration, interaction with other hematotoxic drug administration, renal failure, elderly or immune suppression.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D002648:Child; D002701:Chloramphenicol / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D013839:Thiamphenicol / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D002701:Chloramphenicol; D013839:Thiamphenicol
vernacular_title: Toxicité hématologique du thiamphénicol. A propos de deux observations d'érythroblastopénie aiguë.