Inhibitory action of the ventral noradrenergic bundle on the lateral hypothalamic neurons through alpha-noradrenergic mechanisms in the rat.
Electrical stimulation of the ventral noradrenergic bundle (V-NA bundle) produced 3 types of responses in lateral hypothalamic neurons: IPSPs, a polysynaptic EPSP-IPSP sequence and antidromic spikes. The IPSPs were considered to be monosynaptic due to the fixed latencies seen at stimulus intensities. Iontophoretic application of an alpha-NA antagonist blocked only the presumed monosynaptic inhibition. Most of the glucose-sensitive neurons were inhibited by stimulation of the V-NA bundle. These results may account for the hyperphagia and obesity produced by selective lesions of the V-NA bundle.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004435:Eating; D004558:Electric Stimulation; D005071:Evoked Potentials; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D012528:Satiety Response / Q000502:physiology
D001786:Blood Glucose; D011941:Receptors, Adrenergic; D009638:Norepinephrine