Enhancement of human rotavirus infectivity in a monkey kidney cell line by human expressed breast milk.
Eight of forty (20%) human expressed breast milks enhanced the infectivity of human rotavirus (HRV) when assayed by immunofluorescence in a monkey kidney cell line (LLC-MK2). This enhancement was demonstrated with two HRV strains, one derived from a fecal specimen of a child with acute gastroenteritis, the other a tissue culture adapted strain. The phenomenon could have important implications in the pathogenesis of HRV infections and in future vaccine programs.
D000818:Animals; D002460:Cell Line; D000882:Haplorhini; D007668:Kidney; D008895:Milk, Human / Q000502:physiology*; D012087:Reoviridae / Q000254:growth & development*; D012401:Rotavirus / Q000254:growth & development*