Effect of pertussis vaccine on alpha-adrenoceptors of the circulatory system of the rat.
Administration of pertussis vaccine to rats markedly diminished the sensitivity of their vascular alpha 2-adrenoceptors as evidenced by shifts to the right and decreased maximal pressor responses to clonidine and azepexole in pithed rats. No effect was observed on the sensitivity of alpha 1-adrenoceptors as evidenced by the dose-response curve to methoxamine. A slight persistent tachycardia was also produced by the vaccine. A model to explain the effects of the vaccine on the vascular system of the rat is proposed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010567:Pertussis Vaccine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D013116:Spinal Cord / Q000502:physiology; D014628:Vagotomy
D010567:Pertussis Vaccine; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha