Third-generation cephalosporins for polymicrobial surgical sepsis.
During 31 months of study, 808 patients with polymicrobial surgical infection were randomized for antibiotic therapy between a third-generation cephalosporin (moxalactam disodium [149], cefotaxime sodium [125], and cefoperazone sodium [141]) and the combination of gentamicin sulfate plus clindamycin (393). Results based on antibiotic therapy included the following: cure in 83% given cephalosporin, 73% with antibiotic combination; control but recurrent sepsis in 7% and 15%; and failure in 4% and 8%, respectively. Such data support the tenet that third-generation cephalosporins are at least equal, if not superior, to the combination of gentamicin plus clindamycin for treatment of polymicrobial surgical sepsis.
D000038:Abscess / Q000188:drug therapy / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D002438:Cefoperazone; D002439:Cefotaxime / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use*; D002513:Cephamycins / Q000627:therapeutic use; D002648:Child; D002981:Clindamycin / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009070:Moxalactam; D010532:Peritoneal Diseases / Q000188:drug therapy / Q000209:etiology; D010538:Peritonitis / Q000188:drug therapy / Q000209:etiology; D011183:Postoperative Complications; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000209:etiology
D002511:Cephalosporins; D002513:Cephamycins; D005839:Gentamicins; D002981:Clindamycin; D002438:Cefoperazone; D002439:Cefotaxime; D009070:Moxalactam