title: [Influence of local application of isoptomax eye drops on neuromuscular transmission].
abstract: The muscle-relaxing effect of antibiotics, particularly that of aminoglycosides and polymyxins after oral, intravenous, intramuscular and local application is described. After local application of Isoptomax eye drops, one patient suffered from relaxation of the muscular system of the neck and throat. The phenomenon did not recede until several hours after therapy was discontinued. The mechanism of action is described and a possible treatment discussed with reference to the relevant literature.
mesh_terms: D003907:Dexamethasone / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000009:adverse effects*; D009468:Neuromuscular Diseases / Q000139:chemically induced*; D009883:Ophthalmic Solutions / Q000009:adverse effects* / Q000494:pharmacology; D011112:Polymyxin B / Q000009:adverse effects*; D011113:Polymyxins / Q000009:adverse effects*
chemical_list: D004338:Drug Combinations; D009883:Ophthalmic Solutions; D011113:Polymyxins; C016070:dexamethasone, neomycin, polymyxin B drug combination; D003907:Dexamethasone; D009355:Neomycin; D011112:Polymyxin B
vernacular_title: Beeinflussung der neuromuskulären Ubertragung durch lokale Applikation von Isoptomax-Augentropfen.