Chronic phencyclidine treatment decreases phencyclidine and dopamine receptors in rat brain.
Chronic phencyclidine treatment (10 mg/kg/day, SC for 14 days) significantly decreased the number of [3H]phencyclidine and [3H]spiperone binding sites in rat brain. [3H]Dihydromorphine binding was not affected by the same treatment. An acute treatment with phencyclidine (10 mg/kg, SC) did not modify any of the binding sites under study. These results suggest that a chronic phencyclidine treatment induces a down-regulation of phencyclidine and dopamine receptors without affecting opiate receptors. These reductions in the number of phencyclidine and dopamine binding sites might be related to the development of tolerance and/or dependence to phencyclidine.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004090:Dihydromorphine / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009830:Olfactory Bulb / Q000378:metabolism; D010622:Phencyclidine / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism*; D017478:Receptors, Phencyclidine; D013134:Spiperone / Q000378:metabolism
D011954:Receptors, Dopamine; D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; D013134:Spiperone; D004090:Dihydromorphine; D010622:Phencyclidine