Host Susceptibility to endogenous viruses: defective, glycoprotein-expressing proviruses interfere with infections.
Three defective endogenous avian leukosis viruses, ev3, ev6 and ev9, interfered with subgroup E virus infections, ev3, ev6, and ev9 expressed high levels of subgroup E envelope glycoproteins. These glycoproteins reduced the activity of cellular receptors for subgroup E viruses. ev3 and ev6 protected chickens and cultured cells from subgroup E virus infections.
D000818:Animals; D001354:Avian Leukosis Virus / Q000254:growth & development / Q000502:physiology*; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens / Q000382:microbiology; D003673:Defective Viruses / Q000502:physiology*; D006023:Glycoproteins / Q000502:physiology; D011991:Receptors, Virus / Q000378:metabolism; D011995:Recombination, Genetic; D014759:Viral Envelope Proteins; D014762:Viral Interference; D014764:Viral Proteins / Q000502:physiology*
D006023:Glycoproteins; D011991:Receptors, Virus; D014759:Viral Envelope Proteins; D014764:Viral Proteins