Failure of ACTH to prolong extinction of a conditioned taste aversion in the absence of the testes.
Both corticotropin (ACTH) and testosterone prolong the extinction of a conditioned taste aversion in water-deprived intact male rats. An investigation was made to determine whether ACTH affects extinction in the absence of the testes and also to determine the effect of ACTH on serum testosterone levels. Water-deprived intact males showed prolonged extinction after ACTH injections; water-deprived gonadectomized males and intact females did not. All three of these groups showed elevated testosterone levels after ACTH administration, but testosterone levels were higher in the intact males than in the gonadectomized males or intact females. These results clearly show that in the absence of the testes ACTH is unable to prolong extinction. It is proposed that the increased level of testosterone following ACTH injection in water-deprived intact males is responsible for the prolonged extinction of a conditioned taste aversion. Although testosterone levels may increase in females and castrated males following ACTH injection, the increase is not sufficient to prolong extinction in these water-deprived animals.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002369:Castration; D002712:Chlorides / Q000506:poisoning; D003214:Conditioning, Classical / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects*; D005260:Female; D008094:Lithium / Q000506:poisoning; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*; D014868:Water Deprivation
D002712:Chlorides; D013739:Testosterone; D000324:Adrenocorticotropic Hormone; D008094:Lithium; D018021:Lithium Chloride