An investigation of the antiviral activity of Podophyllum peltatum.
The antiviral activity of an aqueous extract of Podophyllum peltatum was investigated. The extract was fractionated by reversed-phase chromatography, and podophyllotoxin was found to be the most active component in inhibiting the replication of measles and herpes simplex type I viruses. beta-Peltatin and desoxypodophyllotoxin produced marginal antiviral effects, while alpha-peltatin and picropodophyllotoxin were inactive at the levels tested.
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification*; D002522:Chlorocebus aethiops; D002851:Chromatography, High Pressure Liquid; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D007668:Kidney; D008459:Measles virus / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011035:Podophyllum / Q000032:analysis*; D018139:Simplexvirus / Q000187:drug effects; D014776:Virus Cultivation
D000998:Antiviral Agents; D010936:Plant Extracts