Experimental murine hepatitis and inducible suppressor cell function.
We have investigated the changes in inducible suppressor activity in spleen cells of young BALB/c mice infected with A-59 strain of murine hepatitis virus. The peak histological and biochemical damage occurred four days after intraperitoneal inoculation of the virus. Before that, on day 2, there was a transient loss of suppressor activity inducible in splenic cells by in vitro incubation with the mitogen Con A. Sequential changes in the proliferative response of spleen cells to Con A also occurred, but did not account for the loss of inducible suppressor activity. This variation in activity of Con A-stimulated suppressor cells suggests an immunoregulatory role for these cells during experimental viral hepatitis.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D006524:Hepatitis, Viral, Animal / Q000276:immunology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D006517:Murine hepatitis virus; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors
D003208:Concanavalin A