Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.
The anticonvulsant activity of 2-amino-7-phosphonoheptanoic acid (2APH) (an antagonist of excitation induced by N-methyl-D-aspartic acid) was studied against N-methyl-DL-aspartic acid (NMDLA), kainic acid, 3-mercaptopropionic acid (3MPA), thiosemicarbazide (TSC), quinolinic acid, bicuculline, picrotoxin and methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) in Swiss S mice. 2APH, 0.33 mM/kg i.p., antagonizes convulsions induced by NMDLA, 3MPA, TSC, DMCM and picrotoxin but not those produced by the other convulsants. It is proposed that an aspartergic component may contribute to the development of convulsions after 3MPA, TSC, DMCM and picrotoxin.
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology; D003292:Convulsants; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D051379:Mice; D016202:N-Methylaspartate; D011956:Receptors, Cell Surface / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D000596:Amino Acids; D000927:Anticonvulsants; D003292:Convulsants; D011956:Receptors, Cell Surface; D016194:Receptors, N-Methyl-D-Aspartate; D001224:Aspartic Acid; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid; D007608:Kainic Acid