[Manifestations of the neurotoxicity of the organochlorine pesticide dilor during the postnatal period in the rat].
When pregnant rats are administered chlororganic pesticide dilor, certain ultrastructural changes are observed in neurocytes and in myelin fibers, in the spinal cord, that demonstrates some disorders in cellular and tissue metabolism. In the newborn spinal cords a retarded differentiation is observed against the background of an intense cellular metabolism. By means of the electron paramagnetic resonance technique, an increasing concentration of free radicals in the brains and spinal cords of the pregnant animals and in their one-month-old offsprings is demonstrated. The investigation on fatty acid composition of lipids in pregnant test animals demonstrates a decrease in cholysterine, steroids and some fatty acids in myelin fractions and in synaptosomic membranes.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005609:Free Radicals; D007192:Indenes / Q000633:toxicity*; D008055:Lipids / Q000032:analysis; D008854:Microscopy, Electron; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013116:Spinal Cord / Q000032:analysis / Q000187:drug effects* / Q000648:ultrastructure
D005609:Free Radicals; D007192:Indenes; D008055:Lipids; C011780:1,4,5,6,7,8,8-heptachloro-3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indene
Proiavlenie neĭrotoksichnosti khlororganicheskogo pestitsida dilora v postnatal'nom periode u krys.