The role of the major histocompatibility complex in the adoptive transfer of ectromelia virus meningitis.
Adoptive transfer of ectromelia virus meningitis was most efficient when donor-immune spleen cells and recipients were compatible in the K region of the H-2 gene complex. Weak responses could be obtained with H-2D region compatibility, but none occurred with H-2I region compatibility. Spleen cells used in adoptive transfers and cells found in cerebrospinal fluid from infected mice were found to have identical H-2-imposed restriction in their in vitro cytotoxic activity. This suggests a significant role for the major histocompatibility complex in the generation of virus-specific T lymphocytes and the recognition of virus-infected tissue in the central nervous system by these cells.
D000818:Animals; D002452:Cell Count; D002478:Cells, Cultured; D002555:Cerebrospinal Fluid / Q000166:cytology; D003602:Cytotoxicity, Immunologic; D004482:Ectromelia, Infectious / Q000276:immunology* / Q000473:pathology; D006680:HLA Antigens / Q000276:immunology; D007116:Immunization, Passive; D007156:Immunologic Memory; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D008285:Major Histocompatibility Complex; D008587:Meningitis, Viral / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D011213:Poxviridae Infections / Q000276:immunology*; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens