Retrovirus antigens in brains of mice with scrapie- and murine leukemia virus-induced spongiform encephalopathy.
Wild mouse ecotropic virus-induced spongiform encephalomyelopathy pathologically similar to scrapie was associated with the expression of retrovirus antigens in mouse brains. However, scrapie-infected mice with spongiform encephalopathy showed no increased expression of retrovirus antigens in brain. Thus, the pathogenesis of the scrapie spongiform lesion does not appear to involve activation of endogenous retrovirus.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D001921:Brain / Q000276:immunology*; D001927:Brain Diseases / Q000209:etiology / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology; D051379:Mice; D012608:Scrapie / Q000276:immunology*; D012756:Sheep; D013154:Spleen / Q000276:immunology
D000956:Antigens, Viral