Relation between Na+-K+-ATPase activity and dopamine release from rat striatum slices.
Ouabain inhibits potassium induced dopamine release in a competitive manner. On the other hand, amphetamine induced release is facilitated. In dependence on the stimulus power used, the electrically evoked release is reduced by ouabain. Thus, cardiac glycosides represent an appropriate tool for differentiating pools and processes involved in transmitter release, controlled by Na+-K+ ATPase activity.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004298:Dopamine / Q000378:metabolism*; D004347:Drug Interactions; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D004298:Dopamine