Effect of ionizing radiation on platelet function in vitro.
The effect of ionizing radiation on platelet function was investigated in vitro. Platelet-rich plasma (300 x 10(9/1)) was irradiated with doses of 1, 4, 10, 20 and 50 Gy. Platelet function tests were performed on both irradiated and control (non-irradiated) platelet samples. The platelet function tests were (1) platelet aggregation by ADP (1, 2, 4 mumol final concentration), adrenaline and collagen, (2) ADP-release from platelets, (3) clot retraction and (4) platelet factor-3 availability. It was found that roentgen irradiation of platelets in vitro did not affect these platelet functions tests.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000528:radiation effects*; D003018:Clot Retraction; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects / Q000528:radiation effects*; D010977:Platelet Factor 3 / Q000528:radiation effects; D011829:Radiation Dosage
D010977:Platelet Factor 3; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine