Neutralization of the fibrogenic silica-released macrophage factor by antiserum.
Antiserum against the fibrogenic factor from the culture medium of silica-treated rat macrophages was produced in rabbits. In dilution 1: 10,000 the antiserum cancelled the stimulating effect of the culture medium of rat macrophages on the 3H-proline incorporation into granulation-tissue fibroblasts. The rabbit antiserum had variable effects on the stimulation by the media of silica-treated human monocytes, but no effect on the media of cultured human SU-DHL-2-cells.
D000818:Animals; D003238:Connective Tissue / Q000378:metabolism*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D008297:Male; D009000:Monocytes / Q000378:metabolism; D009500:Neutralization Tests; D011392:Proline / Q000378:metabolism; D014176:Protein Biosynthesis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012260:Ribonucleases / Q000378:metabolism; D012822:Silicon Dioxide / Q000494:pharmacology; D013045:Species Specificity
D007106:Immune Sera; D012822:Silicon Dioxide; D011392:Proline; D012260:Ribonucleases