Lack of suppression of insulin secretion by exercise in patients with insulinoma.
Serum glucose, insulin and glucagon concentrations were measured in three patients with insulin-producing tumours of the pancreas while performing an exercise test. In contrast to the normal adrenergic inhibition of insulin release in response to exercise, plasma insulin concentration remained at a constant and high level during exercise in patients with insulinomas. Their plasma glucose concentrations fell during exercise and in the post-exercise period. No significant changes occurred in plasma glucagon concentration. An exercise test may be a useful new diagnostic tool in organic hyperinsulinism.
D007516:Adenoma, Islet Cell / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007340:Insulinoma / Q000097:blood / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000378:metabolism*; D005082:Physical Exertion
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon