[Aspects of megakaryocytic viral production in relation to lymphocytic leukemia in the rat].
Two viral populations BL/F (EL) and BL/F (SL) were derived from RadLV-Rs by propagation in rats where they induced respectively a generalized lymphoma in 5-6 weeks or a thymic lymphoma killing the animals in 5-6 months. In both cases, 10 days after inoculation of viral extract, numerous viral particles are present in the megakaryocytes (MKC) of the bone marrow and the spleen. Our results suggested a production rather than a passive accumulation of those particles by the MKC. The kinetics of blood platelet level for both leukemias showed a thrombocytopenia corresponding with the macroscopic development of the tumor. Therefore the evolution of the blood platelet level is not related to the MKC viremia. This suggests a lack of direct effect of virus BL/F on the MKC metabolism.
D000818:Animals; D017988:Gammaretrovirus / Q000302:isolation & purification* / Q000648:ultrastructure; D007942:Leukemia, Experimental / Q000382:microbiology*; D008533:Megakaryocytes / Q000382:microbiology* / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D051381:Rats; D013953:Thymus Neoplasms / Q000382:microbiology*; D013997:Time Factors
Quelques aspects de la production virale mégacaryocytaire en rapport avec la leucémie lymphoïde chez le rat.