[Fatal granulocyte function defect in a male infant. Results of in vitro and in vivo stimulation with ascorbic acid as well as in vitro stimulation with levamisol and lithium chloride].
We report about a boy who suffered from repeated bacterial infections starting at the age of 4 weeks. A severe defect of chemotactic activity of the neutrophils, and an additional deficient phagocytosis were discovered. The child died at the age of 3 months from septicemia. Chemotactic activity could be stimulated in vitro by ascorbic acid and levamisole but not by lithium chloride. In vivo, however, the effect of ascorbic acid was minimal and treatment with this vitamin could not prevent the lethal end.
D001205:Ascorbic Acid / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D002712:Chlorides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007223:Infant; D007978:Levamisole / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D010587:Phagocytosis / Q000187:drug effects
D002712:Chlorides; D007978:Levamisole; D008094:Lithium; D018021:Lithium Chloride; D001205:Ascorbic Acid
Letaler Granulocytenfunktionsdefekt bei einem männlichen Säugling. Ergebnisse einer in vitro und in vivo Stimulation mit Ascorbinsäure sowie in vitro Stimulation mit Levamisol und Lithiumchlorid.