Regional glucose metabolism in mouse brain following ACTH peptides and naloxone.
Following intracerebroventricular (ICV) injection of ACTH1-24 significant decreases in 2-deoxyglucose (2DG) uptake were observed in frontal cortex and pyriform cortex, and an increase in thalamus. No such changes were observed following ICV MSH/ACTH4-10. Regional changes in 2DG uptake in olfactory bulb, pyriform cortex, thalamus and cerebellum were significantly correlated with the excessive grooming induced by ACTH1-24. Grooming behavior not induced by ACTH1-24 was not correlated with 2DG changes in any of these regions. Naloxone treatment did not significantly alter the regional pattern of 2DG uptake. In naloxone-pretreated mice ACTH1-24 did not induce significant changes in regional 2DG uptake. Following a series of footshocks, 2DG uptake increased in the hypothalamus, tectum and hippocampus. This pattern of changes is different from that observed following ICV ACTH1-24 and cannot therefore be attributed to ACTH secretion during the stress.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003366:Cosyntropin / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology; D004597:Electroshock; D005947:Glucose / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*
D003366:Cosyntropin; D009270:Naloxone; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D003847:Deoxyglucose; D005947:Glucose