Involvement of cyclic AMP in the direct inotropic action of amrinone. Biochemical and functional evidence.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000631:Aminopyridines / Q000494:pharmacology*; D000676:Amrinone; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology; D010210:Papillary Muscles / Q000378:metabolism
D000631:Aminopyridines; D002217:Carbachol; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000676:Amrinone