The use of high-pressure liquid chromatography with electrochemical detection for the assay of nantradol and its application to delta 9- tetrahydrocannabinol.
High-pressure liquid chromatography with electrochemical detection permits sensitive, selective and quantitative analysis of biological and pharmaceutical compounds containing electroactive functional groups. In support of pharmacological and clinical studies with nantradol, a potent, nonopioid analgetic, a specific HPLC/electrochemical assay for nantradol and related compounds in plasma was recently developed. In preliminary studies we have now extended this technique to the detection of delta 9- and 11-OH-delta 9- tetrahydrocannabinol. Results are presented which indicate that HPLC coupled to an electrochemical detector provides sensitivity for these compounds in plasma in the low ng/ml range.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D013759:Dronabinol / Q000097:blood*; D004563:Electrochemistry / Q000379:methods; D006801:Humans; D010617:Phenanthridines / Q000097:blood*
D010617:Phenanthridines; D013759:Dronabinol; C025490:nantradol