The brachymorphic mutation of mice and altered developmental patterns of limb bud 3':5' cyclic adenosine monophosphate.
Concentrations of cyclic AMP (cAMP) were determined in paired fore and hind limbs from day 12-16 of development in murine fetuses homozygous for the brachymorphic (bm) mutation and normal controls. A developmental rise in cAMP occurred 1 day earlier in bm/bm than in +/+ hind limbs and cAMP was higher in day-13 bm/bm than in +/+ fore limbs. Since cAMP is well documented to stimulate chondrogenic differentiation, premature cartilage determination secondary to altered levels of cAMP could play a role in bm/bm short-limbed dwarfism.
D000818:Animals; D002357:Cartilage Diseases / Q000201:enzymology* / Q000235:genetics; D000242:Cyclic AMP / Q000378:metabolism*; D005121:Extremities / Q000201:enzymology; D005260:Female; D005333:Fetus / Q000201:enzymology; D006130:Growth Disorders / Q000201:enzymology* / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy
D000242:Cyclic AMP