[Cholecalciferol metabolism of pregnant rats with vitamin D poisoning].
Four and 24 hours after administering toxic doses of vitamin D3 the concentration of unchanged cholecalciferol in the blood plasma, liver, kidneys, osseous and muscle tissues in pregnant rats was lower than in the control animals. The content of 25-hydroxycholecalciferol in all test tissues of the pregnant rats was higher than in non-pregnant animals. Particularly great amounts of this metabolite are accumulated by the osseous tissue, kidneys and intestine, i.e. by vitamin D target tissues. During vitamin D poisoning the content of 25-hydroxycholecalciferol in embryos and placenta is fairly high, the content in the placenta being greater as compared to the test tissues of the pregnant rats.
D000818:Animals; D002762:Cholecalciferol / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000378:metabolism; D005260:Female; D006887:Hydroxycholecalciferols / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014807:Vitamin D / Q000506:poisoning*
D006887:Hydroxycholecalciferols; D014807:Vitamin D; D002762:Cholecalciferol
Metabolizm kholekal'tsiferola u beremennykh krys pri intoksikatsii vitaminom D.