title: Infection of a calf with the enteric coronavirus strain Paris.
abstract: A tissue-culture-grown enteric coronavirus infected the whole of the gastrointestinal tract and caused enteritis and diarrhoea in a 10-day-old gnotobiotic Friesian calf. Diarrhoea occurred 2 days after inoculation and excretion of virus in faeces and rectal swabs increased until necropsy at 3 days. Virus growth, as detected by indirect immunofluorescence, virus isolation, and thin section electron microscopy, was most extensive in the epithelium of the colon and rectum at 3 days after inoculation. No virus was detected in other organs or in the pleural, peritoneal and oropharyngeal cavities. The origin and host specificity of this coronavirus is discussed.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D003106:Colon / Q000382:microbiology; D003332:Coronaviridae / Q000254:growth & development* / Q000302:isolation & purification; D003333:Coronaviridae Infections / Q000382:microbiology / Q000662:veterinary*; D005243:Feces / Q000382:microbiology; D007413:Intestinal Mucosa / Q000382:microbiology*; D007421:Intestine, Small / Q000382:microbiology; D012007:Rectum / Q000382:microbiology