Activation of dopamine-containing amacrine cells of retina: light-induced increase of acidic dopamine metabolites.
The acidic metabolites of dopamine, homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC), are present in rat retina. DOPAC is the most abundant metabolite. Both metabolites increase in parallel when rats are taken from a dark to a lighted environment. Haloperidol treatment also increases the metabolites in both dark and light while apomorphine decreases both metabolites in dark and light and partially antagonizes the increase induced by haloperidol.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003623:Dark Adaptation / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D008027:Light; D008297:Male; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000166:cytology* / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D014796:Visual Perception / Q000502:physiology*
D015102:3,4-Dihydroxyphenylacetic Acid; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine; D006719:Homovanillic Acid