title: Transferable drug resistance in Pseudomonas patients with premature rupture of membranes in Ile-Ife, Nigeria.
abstract: Pseudomonas aeruginosa was cultured in eight patients with premature rupture of membranes in a Maternity Unit of the University of Ife Teaching Hospital Complex within a period of 48 h. Three of the strains were found to harbour R-factor DNA conferring high-level resistance to benzylpenicillin, streptomycin, chloramphenicol and tetracycline, while two strains are able to transfer this drug resistance en bloc to drug-sensitive Escherichia coli. The significance of this in the light of a continuing study of drug resistant bacteria in Ile-Ife is discussed.
mesh_terms: D002701:Chloramphenicol / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000235:genetics; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology*; D006801:Humans; D011247:Pregnancy; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000235:genetics*; D013307:Streptomycin / Q000627:therapeutic use; D013752:Tetracycline / Q000627:therapeutic use; D014169:Transformation, Bacterial
chemical_list: D002701:Chloramphenicol; D013752:Tetracycline; D013307:Streptomycin