[ACTH, beta-endorphin, lipotropins, and other pro-opiocortin-derived peptides: a new family of hormones (author's transl)].
beta-Endorphin, a pituitary morphino-mimetic peptide, was identified in a culture medium derived from a human corticotropic adenoma. Secretion products from cultured human cells derived from a small-cell carcinoma of the lung were shown to contain a high molecular weight precursor analagous to pro-opiocortin: this molecule is a polypeptide of the order of 28,000 daltons the enzymatic processing of which leads to the coordinated and simultaneous release of different peptide fragments: ACTH, beta- and gamma-lipotropins, beta-endorphin, fragment 16 K and gamma 3-MSH. All these peptides have been identified in human plasma, and pituitary and non-pituitary tumor extracts. Their plasma concentrations vary in a parallel manner, beta-endorphin and a peptide very similar to beta-MSH have been detected in human hypothalamus.
D000236:Adenoma / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D004723:Endorphins / Q000032:analysis* / Q000096:biosynthesis; D006801:Humans; D007031:Hypothalamus / Q000032:analysis; D008175:Lung Neoplasms / Q000378:metabolism; D010902:Pituitary Gland / Q000032:analysis; D010908:Pituitary Hormones, Anterior / Q000032:analysis*; D010911:Pituitary Neoplasms / Q000378:metabolism; D011333:Pro-Opiomelanocortin; D011498:Protein Precursors / Q000032:analysis*; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000032:analysis*
D004723:Endorphins; D010908:Pituitary Hormones, Anterior; D011498:Protein Precursors; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin
ACTH, bêta-endorphine, lipotropines et autres peptides dérivés de la pro-opiocortine: une nouvelle famille d'hormones.