Unique features of retrovirus expression in F/St mice.
F/St mice are unique in producing high levels of both ecotropic and xenotropic murine leukemia virus. The high ecotropic virus phenotype is determined by three or more V (virus-inducing) loci. A single locus for inducibility of xenotropic murine leukemia virus was mapped to chromosome 1 close to, but possibly not allelic to, Bxv-1. Although the high ecotropic virus phenotype is phenotypically dominant, the high xenotropic virus phenotype was recessive in all crosses tested. Suppression of xenotropic murine leukemia virus is governed by a single gene which is not linked to the xenotropic V locus.
D000375:Aging; D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006824:Hybridization, Genetic; D009052:Leukemia Virus, Murine / Q000254:growth & development*; D007942:Leukemia, Experimental / Q000209:etiology; D008223:Lymphoma / Q000209:etiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000382:microbiology; D013601:T-Lymphocytes / Q000382:microbiology; D014775:Virus Activation