Metabolic response to subtotal thyroidectomy in propranolol-treated thyrotoxic patients.
Changes in plasma cortisol, glucose, cyclic AMP, blood leucocytes, pulse rate and body temperature were measured during and for 24 h after subtotal thyroidectomy in eight propranolol-treated (120-160 mg per day) mild to moderate thyrotoxic patients and eight patients with a non-toxic goitre. The results showed a similar metabolic response to surgery in the two groups without any trends towards a hypermetabolic response in the toxic group. The accumulating evidence of the safety of preoperative preparation with propranolol in patients with mild to moderate thyrotoxicosis is thus supported by our results.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature; D000242:Cyclic AMP / Q000097:blood; D006042:Goiter / Q000097:blood / Q000601:surgery; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006980:Hyperthyroidism / Q000097:blood / Q000188:drug therapy / Q000601:surgery*; D007958:Leukocyte Count; D008875:Middle Aged; D011292:Premedication; D011433:Propranolol / Q000627:therapeutic use*; D011674:Pulse; D013965:Thyroidectomy
D001786:Blood Glucose; D011433:Propranolol; D000242:Cyclic AMP; D006854:Hydrocortisone