Primary anterior mediastinal seminoma.
A review of the Mayo Clinic experience with primary anterior mediastinal seminomas involved 17 patients who had pure anterior mediastinal seminomas and four who had mixed germ-cell tumors containing seminomas. At follow-up, of the 17 patients with pure anterior mediastinal seminoma, nine had no evidence of disease and eight had died of metastatic disease. Of the four patients with mixed germ-cell tumor containing seminoma, two were alive at follow-up and two had died of metastatic disease. In the group with pure anterior mediastinal seminoma, these factors seemed to have been associated with a greater potential for progression of disease: older than 35 years of age, presentation with fever, superior vena caval syndrome, supraclavicular or cervical adenopathy, and roentgenographic evidence of hilar disease.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001706:Biopsy; D001859:Bone Neoplasms / Q000556:secondary; D004407:Dysgerminoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005334:Fever; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D014684:Venae Cavae