[Effect of ACTH4-7 and lysyl-vasopressin on the activity of a generator of pathologically enhanced excitation].
It was shown in experiments on random-bred rats that ACTH4-7 and lysine-vasopressin promoted the maintenance of the activity in the generator of pathologically enhanced excitation (PEE) created in the anterior horns of the lumbosacral segments of the spinal cord. The effect described manifested clinically in the prolongation of the hypertonus maintenance, and increased electrical activity in the muscles of the appropriate hind limb as compared with the same parameters in the control animals. The effect seen is discussed from the standpoint of the influence of the peptides under consideration on the generator of PEE as on a peculiar form of the pathological memory.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D000818:Animals; D004594:Electrophysiology; D008236:Lypressin / Q000627:therapeutic use*; D008568:Memory / Q000187:drug effects; D009132:Muscles / Q000503:physiopathology; D009468:Neuromuscular Diseases / Q000188:drug therapy* / Q000503:physiopathology; D010446:Peptide Fragments / Q000627:therapeutic use*; D051381:Rats; D013118:Spinal Cord Diseases / Q000188:drug therapy* / Q000503:physiopathology
D010446:Peptide Fragments; D008236:Lypressin; C029578:ACTH (4-7); D000324:Adrenocorticotropic Hormone
Vliianie AKTG4-7 i lizil-vazopressina na aktivnost' generatora patologicheski usilennogo vozbuzhdeniia.