title: [Human pharmacology of ceftriaxone (author's transl)].
abstract: The human pharmacology of ceftriaxone was studied in five healthy adult subjects receiving a 500 mg dose intravenously. Evolution of serum levels represents a two compartment open model; the distribution volumes, central and peripheric, were low (about 3 L); the elimination half-life was particularly long : 7.87 hours; the renal and serum clearances and low. These data are probably related to the high affinity of the drug for serum proteins (95 p. cent bound); they suggest once daily parenteral dosing.
mesh_terms: D000328:Adult; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D002443:Ceftriaxone; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D011485:Protein Binding
chemical_list: D002443:Ceftriaxone; D002439:Cefotaxime
vernacular_title: Pharmacocinétique de la ceftriaxone chez l'homme.