[Age-related changes of cAMP and prostaglandin content in the brain and lymphocytes of spontaneously tumor-producing C3H mice].
Age caused concurrent changes in the activation of the adenylate-cyclase activity by dopamine in the diencephalon and the stimulation of the basal level of cAMP by isoproterenol in the lymphocytes were demonstrated in the spontaneously tumor producing C3H mice. These changes may be related to the occurrence of tumors in these animals. The above-mentioned changes in the cAMP system were not found in AB mice. By treating the adult C3H mice with substances which increase the cAMP level, it was possible to achieve a renewed stimulation of the cAMP system as seen in young mice. With this treatment the spontaneous tumor-induction rate was also reduced. In the adenocarcinomas of the C3H mice a decrease in the level of prostaglandin E and an increase in the level of prostaglandin F2 alpha was observed.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000367:Age Factors; D000547:Amantadine / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D000242:Cyclic AMP / Q000378:metabolism*; D004027:Diencephalon / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008214:Lymphocytes / Q000032:analysis* / Q000187:drug effects; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011453:Prostaglandins / Q000032:analysis*; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D000547:Amantadine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D004298:Dopamine
Altersbedingte Veränderungen des cAMP-und Prostaglandingehaltes im Gehirn und in den Lymphozyten von spontan mammakarzinombildenden C3H-Mäusen.