[Problems in the treatment of a patient with longstanding epilepsy (author's transl)].
The case of a female patient with longstanding epilepsy is reported. Many problems in achieving a satisfactory therapeutic regimen were encountered. They originated in storage of phenobarbital, which had been prescribed since childhood, interference between phenobarbital, dipropylacetic acid, and phenylhydantoins. Some pharmacokinetic principles are reviewed in the light of this clinical experience.
D000328:Adult; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010634:Phenobarbital / Q000378:metabolism / Q000627:therapeutic use; D010672:Phenytoin / Q000378:metabolism / Q000627:therapeutic use; D014635:Valproic Acid / Q000378:metabolism / Q000627:therapeutic use
D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital
Problèmes thérapeutiques chez une épileptique ancienne.