A factor in food which impairs Na+-K+-ATPase in vitro.
Extracts of foods were examined to identify materials which inactivate Na+-K+-dependent ATPase. Active material which we call food factor was found in tea, cocoa, red wines, and in certain other dietary components. A unit of activity is defined and the material is compared with ouabain and an inhibitory flavone. The possible role of such a food factor in the regulation of sodium metabolism and in the causation of essential high blood pressure is discussed.
D002099:Cacao; D005504:Food Analysis; D006801:Humans; D006973:Hypertension / Q000201:enzymology; D066298:In Vitro Techniques; D010042:Ouabain / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013634:Tannins / Q000494:pharmacology; D013662:Tea; D014675:Vegetables
D013634:Tannins; D013662:Tea; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase