Pharmacokinetics of ceftriaxone following intravenous administration of a 3 g dose.
The pharmacokinetic parameters of total (bound and unbound) and free (unbound) ceftriaxone in six healthy volunteers after intravenous injection of 39 were compared with low-dose data from a previous study. The dose-dependent behaviour of total drug was considerably more pronounced after the 3 gram dose. In contrast, total body clearance (C1FS = 258 ml/Min), renal clearance (C1FR = 170 ml/min) and volume of distribution (VFD (beta) = 168 1) of free (unbound) drug did not differ from the data reported earlier. There was no significant change in biological half-life (t1/2 (beta) = 7.8 h) or in the fraction excreted unchanged in urine (fu = 0.67).
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D002443:Ceftriaxone; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011485:Protein Binding
D001798:Blood Proteins; D002443:Ceftriaxone; D002439:Cefotaxime