Lithium does not prevent ECS-induced decreases in beta-adrenergic receptors.
Electroconvulsive shock (ECS) reduces the number of rat cortical beta-adrenergic receptors. Lithium has been reported in several systems to prevent receptor changes induced by other agents. However, the present experiment reports that chronic lithium does not prevent the reduction in dihydroalprenolol binding induced by ten daily ECS treatments.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D004082:Dihydroalprenolol; D004597:Electroshock; D007700:Kinetics; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D012640:Seizures / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D008094:Lithium