Catechol estradiol induced implantation in the mouse.
Induction of implantation is among the most sensitive responses to estrogens. The ability of catechol estradiols, 4-hydroxy-estradiol-17 beta (4-OH-E2) and 2-hydroxy-estradiol-17 beta (2-OH-E2), to induce implantation in ovariectomized pregnant mice was compared to that of estradiol-17 beta. Delayed implantation was maintained by the daily administration of 2 mg of progesterone. A single injection of 3 ng of estradiol-17 beta, 50 ng of 4-OH-E2, or 2,000 ng of 2-OH-32 consistently induce a full complement of implantation sites in all animals. Before the estrogenicity of the latter steroid can be established the lack of contaminating estrogens must be proved.
D000818:Animals; D002369:Castration; D010064:Embryo Implantation / Q000187:drug effects*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D002393:Estrogens, Catechol / Q000494:pharmacology*; D005260:Female; D051379:Mice; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology
D002393:Estrogens, Catechol; D011374:Progesterone; D004958:Estradiol; C001390:2-hydroxyestradiol; C014036:4-hydroxyestradiol