[Activation succinate dehydrogenation in rat liver by noradrenaline, cAMP and acute cooling].
Administration of noradrenaline in a dose of 11 mumol/kg activates succinate dehydrogenase (SDH) in the rat liver. On incubation of liver homogenate with noradrenaline (10(-6) M), cAMP (10(-6) M) and NaF (10(-2) M), a nonhormonal activator of adenylate cyclase, SDH was found to be activated by 20--30% in all the cases. The effects of noradrenaline and cAMP did not sum up. It seems likely that SDH activation by catecholamines is mediated by cAMP. Acute cooling (--17 degrees C) stimulates SDH via endogenous catecholamines, since this effect is completely reversed by the beta-adrenolytic inderal.
D000818:Animals; D002395:Catecholamines / Q000502:physiology; D003080:Cold Temperature; D000242:Cyclic AMP / Q000494:pharmacology*; D004347:Drug Interactions; D004789:Enzyme Activation; D005260:Female; D008099:Liver / Q000201:enzymology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology
D002395:Catecholamines; D012969:Sodium Fluoride; D000242:Cyclic AMP; D009638:Norepinephrine
Aktivatsiia degidrirovaniia suktsinata v pecheni krys pod vliianiem noradrenalina, tsAMF i ostrogo okhlazhdeniia.