[Effect of antibiotic and vaccine therapies on the succinate dehydrogenase and phosphatase activity of liver cells of mice infected with Staphylococcus].
Changes in the activity of succinate dehydrogenase (SDH), total and acid phosphatase (TP and AP) were studied in treatment of laboratory animals with rifampicin, lincomycin and with inactivated staphylococcal vaccine used alone or in combinations. It was shown that immunization of the animals with inactivated staphylococcal vaccine under conditions of experimental staphylococcal infection promoted stimulation of the enzyme activity. Rifampicin and lincomycin used for the treatment of such animals lowered the activity of the enzymes. The suppressing effect of the antibiotics increased with an increase in the period of their use. It should be noted that the inhibitory effect of rifampicin on the activity of SDH, TP and AP was less pronounced than that of lincomycin. The combined use of the vaccine and antibiotics for the treatment of the animals promoted an increase in the enzyme activity as compared to the use of the antibiotics alone. Sometimes the activity of SDH, TP and AP reached the control levels in such animals or the levels observed in the animals treated with the vaccine alone. Stimulation of the enzyme activity was more pronounced when the vaccine was used in combination with rifampicin.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008034:Lincomycin / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D012293:Rifampin / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000201:enzymology; D013209:Staphylococcal Vaccines / Q000627:therapeutic use*; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D013997:Time Factors
D013209:Staphylococcal Vaccines; D008034:Lincomycin; D013385:Succinate Dehydrogenase; D010744:Phosphoric Monoester Hydrolases; D012293:Rifampin
Vliianie antibiotikoterapii i vaktsinoterapii na aktivnost' suktsinatdegidrogenazy i fosfatazy v kletkakh pecheni u mysheĭ, infitsirovannykh stafilokokkom.