Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D002308:Cardiolipins / Q000502:physiology*; D002417:Cattle; D004317:Doxorubicin / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D007700:Kinetics; D008929:Mitochondria, Heart / Q000201:enzymology*; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D002308:Cardiolipins; D004317:Doxorubicin; D003576:Electron Transport Complex IV