[Functional properties of the catecholamine-sensitive adenyl cyclase system in embryonic skeletal muscle].
During embryogenesis the adenylate cyclase from chicken skeletal muscle possesses a high catalytic activity in comparison with the mature tissue. The embryonic muscle enzyme is sensitive to the stimulating effects of fluoride, vanadate and guanyl nucleotides. The enzyme sensitivity to catecholamines appears at the end of the 2nd week of embryogenesis. Activation of chicken skeletal muscle adenylate cyclase by catecholamines occurs via the adrenoreceptor of the beta-type. Upon combined action of guanyl nucleotides and adrenaline the potentiation effect typical for the mature muscle is observed only at post-embryonic stages. It is assumed that the functional development of the catecholamine--sensitive adenylate cyclase system in embryogenesis occurs in the following order: catalytic, regulatory, receptor components. The process is completed at the post-embryonic stage.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D002642:Chick Embryo; D005459:Fluorides / Q000494:pharmacology; D006150:Guanine Nucleotides / Q000494:pharmacology; D007700:Kinetics; D009132:Muscles / Q000196:embryology / Q000201:enzymology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D014638:Vanadates; D014639:Vanadium / Q000494:pharmacology
D002395:Catecholamines; D006150:Guanine Nucleotides; D011943:Receptors, Adrenergic, beta; D014639:Vanadium; D014638:Vanadates; D000262:Adenylyl Cyclases; D005459:Fluorides
Izuchenie funktsional'nykh svoĭstv katekholaminchuvstvitel'noĭ adenilattsiklaznoĭ sistemy v émbrional'noĭ skeletnoĭ myshtse.