Effects of beta-endorphin, thyrotropin-releasing hormone and cholecystokinin on body shaking behavior in rats.
Effects of intracerebroventricular administration of beta-endorphin, thyrotropin-releasing hormone (TRH), cholecystokinin octapeptide (CCK-8), non-sulfated CCK-8 (CCK-8-NS) and caerulein on body shaking behavior were observed in rats. CCK-8 and its related peptides produced only a small increase in the number of body shakes, while TRH had the striking effect of stimulating body shakes, this increase being markedly suppressed by simultaneous administration of beta-endorphin. Moreover, the suppressive effect of beta-endorphin on TRH-induced body shakes was antagonized by simultaneous administration of caerulein and CCK-8. The body shakes induced by ice-water immersion were also reduced by beta-endorphin, this beta-endorphin effect being partly antagonized by caerulein and CCK-8.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002108:Ceruletide / Q000494:pharmacology; D002766:Cholecystokinin / Q000494:pharmacology*; D003080:Cold Temperature; D004723:Endorphins / Q000494:pharmacology*; D007101:Immersion; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D001615:beta-Endorphin
D004723:Endorphins; D010446:Peptide Fragments; D013973:Thyrotropin-Releasing Hormone; D001615:beta-Endorphin; D002108:Ceruletide; D002766:Cholecystokinin; D012844:Sincalide