title: Formation of ether lipids from isomeric cis-octadecen-1-ols in normal and neoplastic cells: substrate specificity of enzymes with regard to position of double bonds.
abstract: The pattern of incorporation of isomeric cis-[1-14C]octadecen-1-ols into alkyl moieties of glycerophospholipids of rat brain as well as of L 1210 and S 180 murine ascites cells revealed the following: 1) The enzymes involved in the biosynthesis of acylalkylglycerophospholamines have no substrate specificity with regard to position of the double bond of either cis-oectadecen-1-ols or of intermediate ether lipids derived therefrom. 2) CDPcholine: diradylglycerol cholinephosphotransferases exhibit a strong preference for acylalkylglycerols with cis-8, cis-9 and cis-10-octadecenyl moieties as substrates.
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D005233:Fatty Alcohols / Q000378:metabolism*; D005990:Glycerol / Q000031:analogs & derivatives* / Q000378:metabolism; D007700:Kinetics; D007939:Leukemia L1210 / Q000201:enzymology*; D050356:Lipid Metabolism; D051379:Mice; D010742:Phospholipid Ethers; D010743:Phospholipids / Q000096:biosynthesis; D010770:Phosphotransferases / Q000378:metabolism*; D012510:Sarcoma 180 / Q000201:enzymology*; D013379:Substrate Specificity
chemical_list: D005233:Fatty Alcohols; D010742:Phospholipid Ethers; D010743:Phospholipids; C010268:oleyl alcohol; D010770:Phosphotransferases; D005990:Glycerol