title: [Quantitative evaluation of the content of antibodies to hepatitis of A virus in serial immunoglobulin preparations].
abstract: A total of 156 samples of several lots of immune serum globulin (ISG) were tested for antibodies to hepatitis A virus (anti-HAV). In this study the blocking variant of the solid-phase enzymoimmunological method was used. The samples under test were the production of 12 manufacturing enterprises in the USSR and I enterprise in Czechoslovakia. All the samples under test were found to contain anti-HAV within the limits from 2500-5000 to 20000-40000. The samples produced by different manufacturing enterprises showing no essential differences in the content of anti-HAV. Most preparations (93.6%) contained antibodies at levels of 5000-20000. The ISG proposed as the international standard preparation had a titer of 8000-10000. No differences in the content of anti-HAV were detected in comparing ISG whose shelf life expired 4 years before the test with ISG whose shelf life was to expire 3 years later. The results obtained in this study are discussed in connection with the immunoprophylaxis of viral hepatitis A.
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D003604:Czechoslovakia; D004356:Drug Storage; D006507:Hepatovirus / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis*; D014586:USSR
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins
vernacular_title: Kolichestvennaia otsenka soderzhaniia antitel k virusu gepatita A v seriĭnykh preparatakh immunoglobulina.