[Effect of chronic presynaptic neuromuscular transmission blockade on the properties of frog muscle fiber membranes].
It has been discovered in experiments on frogs that muscle denervation removes the membrane rest potential, increases the input resistance and time constant of the membrane, expands the zone of muscular fiber sensitivity to acetylcholine. Long-term disturbance by tetrodotoxin of the excitation conduction in the motor nerve or presynaptic blockade of neuromuscular transmission by hemicholinium-3 do not change the membrane rest potential and time constant of the membrane or the size of the zone of muscular fiber sensitivity to acetylcholine but increase the input resistance of the muscle membrane. It is inferred that in the frog, presynaptic blockade of the excitation conduction from the nerve to the muscle is not equivalent to its denervation.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D006426:Hemicholinium 3 / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000502:physiology*; D011895:Rana ridibunda; D009435:Synaptic Transmission / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology*; D013997:Time Factors
D006426:Hemicholinium 3; D013779:Tetrodotoxin; D000109:Acetylcholine
Vliianie khronicheskoĭ presinapticheskoĭ blokady nervno-myshechnoĭ peredachi na svoĭstva membrany myshechnykh volokon u liagushki.