Inversion of the metabolic zonation of rat liver parenchyma by methapyrilene treatment.
Treatment with the antihistaminic agent methapyrilene led to a decrease of glucose-6-phosphatase activity and to an increase of glucose phosphorylating activity in the periportal zone of the liver acinus. However, the glucogenic capacity was maintained by a compensatory elevation of glucose-6-phosphatase and simultaneous reduction of hexokinase and glucokinase in the perivenous zone. The normal metabolic zonation with a glucogenic periportal and a glycolytic perivenous zone was not abolished but inverted by these alterations.
D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005941:Glucokinase / Q000378:metabolism; D005943:Gluconeogenesis / Q000187:drug effects*; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D006593:Hexokinase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008701:Methapyrilene / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000631:Aminopyridines; D008701:Methapyrilene; D006593:Hexokinase; D005941:Glucokinase; D005952:Glucose-6-Phosphatase