Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4.
The ability of intradermally injected leukotrienes C4 (LTC4), LTD4 and LTB4 to produce inflammatory changes in human skin alone and in combination with prostaglandin E2 (PGE2) has been investigated. LTC4 and D4 (0.012-0.38 nmol) caused dose-related erythema and wealing. No evidence of synergism between PGE2 and LTC4 or LTD4 was detected, although only single dose combinations were studied. LTB4 (0.15-1.5 nmol) caused areas of induration which persisted for more than 4 h and which showed perivascular neutrophil infiltrates on histological examination. Only slight synergism between PGE2 and LTB4 was found. It was concluded that these pro-inflammatory properties of LTC4, LTD4 and LTB4 are consistent with their proposed roles as mediators of inflammation in the skin and other tissues.
D000328:Adult; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007271:Injections, Intradermal; D007975:Leukotriene B4 / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011458:Prostaglandins E / Q000494:pharmacology; D013189:SRS-A / Q000494:pharmacology*; D012867:Skin / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology
D011458:Prostaglandins E; D013189:SRS-A; D007975:Leukotriene B4; D015232:Dinoprostone