Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse.
A cDNA clone corresponding to a mRNA present at elevated levels in transformed fibroblasts encodes a Qa/Tla class I major histocompatibility complex (MHC) antigen. High levels of this mRNA are found in all tumour cells tested; the transcript can undergo alternative splicing; and a repetitive sequence within the transcription unit has the characteristics of a transposable element. The immunological implications of MHC gene activation in tumour cells are discussed.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D001483:Base Sequence; D002460:Cell Line; D002472:Cell Transformation, Viral; D004251:DNA Transposable Elements; D005786:Gene Expression Regulation; D015395:Histocompatibility Antigens Class I; D008285:Major Histocompatibility Complex; D051379:Mice; D012326:RNA Splicing; D012091:Repetitive Sequences, Nucleic Acid; D013724:Teratoma / Q000235:genetics; D015533:Transcriptional Activation
D000954:Antigens, Surface; D004251:DNA Transposable Elements; D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens