Pharmacology of ketoconazole suspension in infants and children.
The pharmacokinetics of ketoconazole administered as either a commercially prepared suspension or as a crushed tablet in applesauce were studied in 12 children. The mean peak plasma concentration of ketoconazole and the area under the plasma time-concentration curve were approximately twofold greater with the suspension than with the crushed tablets.
D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D007654:Ketoconazole; D007700:Kinetics; D008297:Male; D010879:Piperazines / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D013535:Suspensions; D013607:Tablets
D007093:Imidazoles; D010879:Piperazines; D013535:Suspensions; D013607:Tablets; D007654:Ketoconazole