title: Chronic diabetes decreases the ouabain inotropic response in rat left atria and papillary muscles.
abstract: The inotropic response to ouabain in rat left atria were markedly depressed in animals made diabetic for 6 months. Similarly, ouabain inotropy was also decreased in papillary muscles obtained from 70-day diabetic rats. The effect of isoproterenol was not reduced in the above papillary muscle experiments and was not tested in the atria experiments. Ouabain produced a monophasic dose-response curve in atria but a biphasic curve in papillary muscles. Timolol had no effect on the ouabain response. Left atria and papillary muscles from animals made diabetic for 7 days responded in a normal fashion to both ouabain and isoproterenol.
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005260:Female; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D010042:Ouabain / Q000494:pharmacology*; D010210:Papillary Muscles / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug / Q000032:analysis; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis
chemical_list: D011955:Receptors, Drug; C028996:cardiac glycoside receptors; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D007545:Isoproterenol