[3H]-SKF 10047 binding to rat brain membranes: evidence for kappa isoreceptors.
Studies of the binding of [3H]-SKF10047 to rat brain membrane preparations revealed a binding site which possessed high affinity for kappa and agonist/antagonist analgesics. However, this site was distinguished from kappa sites labelled with [3H]-ethylketazocine by its high affinity for Met5-enkephalin Arg6.Phe7 and beta-endorphin as well as its low affinity for dynorphin 1-13. We therefore tentatively suggest that this may represent a possible kappa isoreceptor population.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D010620:Phenazocine / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism*; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu
D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; C012134:SK&F 10047; D010620:Phenazocine