Studies on osteoporoses. VIII. Effect of estrogen on steroid induced osteoporosis.
Neutron activation analysis was employed to determine total body calcium in 5-8 month and 15-18 month old C3H/St(Ha) and C57/BL6 (JACOBS) female mice. Ninety-nine percent of calcium is in bone and loss of calcium was used as an index of osteoporosis. Prednisolone (50 mg/kg q.d.) treatment for three months resulted in significant osteoporosis in the C3H/St(Ha) mice of both age groups but did not cause significant bone loss in the C57/BL6 (JACOBS) mice of either age group. Premarin (20 mg/kg q.d.) failed to prevent steroid accelerated osteoporosis.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000375:Aging; D000818:Animals; D002118:Calcium / Q000032:analysis; D004967:Estrogens / Q000494:pharmacology*; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010024:Osteoporosis / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D011239:Prednisolone / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D011239:Prednisolone; D002118:Calcium