Effects of antiemetics on the acquisition and recall of radiation- and lithium chloride-induced conditioned taste aversions.
A series of experiments were run to evaluate the effect of antiemetics on the acquisition and recall of a conditioned taste aversion induced by exposure to ionizing radiation or by injection of lithium chloride. Groups of male rats were exposed to 100 rad gamma radiation or 3 mEq/kg lithium chloride following consumption of a 10% sucrose solution. They were then injected with saline or with one of three antiemetics (prochlorperazine, trimethobenzamide, or cyclizine) at dose levels that have been reported to be effective in attenuating a previously acquired lithium chloride-induced taste aversion. The pretreatments with antiemetics had no effect on the acquisition or recall of either the lithium chloride- or radiation-induced taste aversion. The data suggest that antiemetics do not disrupt lithium chloride-induced taste aversions as previously reported, nor do they effect radiation-induced taste aversion learning.
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects* / Q000528:radiation effects; D001549:Benzamides / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D003501:Cyclizine / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D018021:Lithium Chloride; D008297:Male; D011346:Prochlorperazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects*
D000932:Antiemetics; D001549:Benzamides; D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride; D003501:Cyclizine; C100146:trimethobenzamide; D011346:Prochlorperazine