In-vitro sensitivity of Bordetella pertussis.
The in-vitro effect of ampicillin, chloramphenicol, clindamycin, erythromycin, trimethoprim and trimethoprim-sulphamethoxazole against 152 strains of Bordetella pertussis was investigated. When tested against erythromycin, 96% of the isolated strains were inhibited by less than or equal to 1 mg/l. The other antibiotics did not inhibit the growth of Bord. pertussis at concentrations judged achievable in-vivo.
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001886:Bordetella pertussis / Q000187:drug effects*; D004338:Drug Combinations / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D004917:Erythromycin; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole