[Identification and the origin of oncogenes, with special reference to sarcoma virus Y73].
A new sarcomagenic transforming gene, yes, was identified in an avian sarcoma virus Y73. The gene product is a gag-fused polyprotein p90yes and have protein kinase activity phosphorylating tyrosine residues in proteins. Vertebrates from fish to human were shown to contain DNA sequence (c-yes) homologous with viral yes. Total nucleotide sequence of Y73 genome was determined and the predicted amino acid sequence of p90yes was found to be highly homologous with p60src, a gene product of src in Rous sarcoma virus. These findings suggest that transforming gene yes and src are diverged from a common prototype onc gene at very early stage of vertebrate development or before that and conserved during the development since it plays an essential role.
D000595:Amino Acid Sequence; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005814:Genes, Viral; D005815:Genetic Code; D006801:Humans; D009857:Oncogenes; D010764:Phosphorylase Kinase / Q000235:genetics; D014443:Tyrosine / Q000378:metabolism
D014443:Tyrosine; D004247:DNA; D010764:Phosphorylase Kinase