Disorders of stimulus-response coupling in neutrophils.
The initiation of both the normal and pathologic responses of human neutrophils to surface stimulation and the ensuing biochemical and physiologic events are elucidated. This knowledge has contributed to an understanding of the controlling mechanisms that may account for impaired phagocytic function in several clinical disorders associated with recurrent bacterial infections.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001770:Blood Bactericidal Activity; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion; D002609:Chediak-Higashi Syndrome / Q000097:blood; D002634:Chemotaxis, Leukocyte; D002648:Child; D000242:Cyclic AMP / Q000097:blood; D003594:Cytoplasmic Granules / Q000378:metabolism; D006105:Granulomatous Disease, Chronic / Q000097:blood; D006168:Guinea Pigs; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D007781:Lactoferrin / Q000172:deficiency; D008297:Male; D008564:Membrane Potentials; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology* / Q000502:physiology; D009895:Opsonin Proteins / Q000502:physiology; D010101:Oxygen Consumption; D010585:Phagocyte Bactericidal Dysfunction / Q000097:blood; D010587:Phagocytosis; D011817:Rabbits
D001095:Arachidonic Acids; D007473:Ion Channels; D009895:Opsonin Proteins; D016718:Arachidonic Acid; D000242:Cyclic AMP; D007781:Lactoferrin; D002118:Calcium