[Effect of (L-Phe7) and (D-Phe7) ACTH 4-7 and an ACTH 4-7 analog with prolonged action on acetylcholinesterase activity in the rat brain].
ACTH4-7 and its long-acting analog stimulate acetylcholinesterase activity of different areas of the rat brain. Based on the data concerning the effect of an amino acid mixture equivalent to ACTH4-7 and actinomycin D on acetylcholinesterase activity of the white substance of the large hemispheres it is inferred that the oligopeptide-induced increase in the enzyme activity is linked with the induction of the synthesis of new acetylcholinesterase molecules.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002531:Cerebellum / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D003609:Dactinomycin / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004789:Enzyme Activation / Q000187:drug effects; D007279:Injections, Subcutaneous; D010446:Peptide Fragments / Q000008:administration & dosage*; D051381:Rats
D003692:Delayed-Action Preparations; D010446:Peptide Fragments; D003609:Dactinomycin; C029578:ACTH (4-7); D000324:Adrenocorticotropic Hormone; D000110:Acetylcholinesterase
Vliianie (L-Phe7) i (D-Phe7) AKTG 4-7 i analoga AKTG 4-7 prolongirovannogo deĭstviia na aktivnost' atsetilkholinésterazy golovnogo mozga krys.