[Effect of protein-markers of growth on oxidative phosphorylation in mitochondria].
Growth marker proteins (GMP) were studied for their effect on oxidative phosphorylation in the heart and liver mitochondria of rabbits. It is shown that GMP decrease a respiratory control (RC) coefficient, P/O coefficient, inhibit respiration of the mitochondria in metabolic states 3, 5 and activates it in state 4. The nature of the oxidation substrates (FAD- and NAD-dependent succinic and pyruvic acids, respectively) does not influence the GMP effect manifestation. It is supposed that GMP disturb the structural and functional integrity of the mitochondria. Variations in bioenergetic parameters of the heart and liver mitochondria in organisms with active growth foci as well as of mitochondria incubated with GMP, are unidirectional. Cytochrome c, coenzyme A (Co ASH) and other thyol compounds (cystein, dithiotreitol, glutathione--GSH) remove the GMP action.
D000818:Animals; D003065:Coenzyme A / Q000378:metabolism; D003574:Cytochrome c Group / Q000378:metabolism; D006157:Guanosine Monophosphate / Q000494:pharmacology; D007700:Kinetics; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D011506:Proteins / Q000494:pharmacology*; D011817:Rabbits
D003574:Cytochrome c Group; D011506:Proteins; D006157:Guanosine Monophosphate; D003065:Coenzyme A
Vliianie belkov-markerov rosta na okislitel'noe fosforilirovanie v mitokhondriiakh.