Effects of cimetidine and ranitidine on the "lipoperoxide" and lipid content of liver of rats treated with CCl4, colchicine, ethanol, ethionine and emetine.
Ranitidine increases liver "lipoperoxide" content of colchicine-treated rats while decreasing that of rats given emetine. Lipid content is increased by ranitidine in livers of rats dosed with ethanol. No significant effects of ranitidine were observed under the other conditions here studied. Cimetidine does never provoke significant modifications.
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002927:Cimetidine / Q000494:pharmacology*; D003078:Colchicine / Q000633:toxicity; D004640:Emetine / Q000633:toxicity; D000431:Ethanol / Q000633:toxicity; D005001:Ethionine / Q000633:toxicity; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism*; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D011899:Ranitidine / Q000494:pharmacology*; D051381:Rats
D008054:Lipid Peroxides; D008055:Lipids; D000431:Ethanol; D002927:Cimetidine; D011899:Ranitidine; D002251:Carbon Tetrachloride; D003078:Colchicine; D005001:Ethionine; D004640:Emetine