[Urinary schistosomiasis. 1st trial of mass treatment in the field (Niger)].
In a village of 841 inhabitants, we were able to examine 553 subjects, 357 of whom had urinary egg excretion. The patients were treated with a single dose of 35 mg/kg oltipraz which was given under surveillance together with either whole milk or herrings in oil. The tolerance of the product was very good as only 3% of the patients reported vomiting and 3% paresthesias of the fingers. 66% of the patients examined on day 30 and/or on day 90 were egg-negative and egg excretion was reduced by at least 90% in 22 other subjects, bringing the percentage of good results to 74%. On day 90, the mean egg excretion was reduced by 82.5% in the overall population and by 80.9% in the 5 to 14 year-olds.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008403:Mass Screening; D009548:Niger; D010270:Parasite Egg Count; D011719:Pyrazines / Q000009:adverse effects / Q000627:therapeutic use*; D012552:Schistosomiasis / Q000188:drug therapy* / Q000453:epidemiology; D012556:Schistosomicides / Q000627:therapeutic use*; D012737:Sex Factors; D013871:Thiones; D013876:Thiophenes; D014552:Urinary Tract Infections / Q000188:drug therapy*
D011719:Pyrazines; D012556:Schistosomicides; D013871:Thiones; D013876:Thiophenes; C026209:oltipraz
Schistosomose urinaire. Premier essai de traitement de masse sur le terrain (Niger).