Presence of Epstein-Barr virus DNA in carcinomas of the palatine tonsil.
The presence of Epstein-Barr virus genetic material was demonstrated in thin sections of biopsy specimens in 6 of 7 carcinomas of human palatine tonsil by the in situ hybridization test. The biopsy specimens from 4 tonsillar carcinomas exhibited a strong positive reaction; two biopsy specimens were weakly positive. Two tumor-free biopsy specimens were negative. None of the thin sections reacted with 3H-labeled herpes simplex virus DNA probe.
D000328:Adult; D000368:Aged; D001345:Autoradiography; D001706:Biopsy; D002460:Cell Line; D004273:DNA, Neoplasm / Q000032:analysis*; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D004854:Herpesvirus 4, Human; D006651:Histocytochemistry; D006801:Humans; D008214:Lymphocytes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D010159:Palate; D018139:Simplexvirus; D014067:Tonsillar Neoplasms / Q000032:analysis*
D004273:DNA, Neoplasm; D004279:DNA, Viral