cAMP in guinea-pig superior cervical ganglia during preganglionic nerve stimulation.
Preganglionic nerve stimulation or elevated [K+]o increase cAMP levels in isolated guinea-pig superior cervical ganglia, a ganglion lacking adrenergic inhibitory synaptic potentials. The cAMP response to K+ and nerve stimulation is not prevented by atropine or phentolamine. The regulation of cAMP content does not involve cholinergic or adrenergic mechanism. Of polypeptides tested, only VIP (5 X 10(-6) M) increases cAMP content to the extent observed with preganglionic nerve stimulation.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D004558:Electric Stimulation; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D006168:Guinea Pigs; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D014660:Vasoactive Intestinal Peptide; D001285:Atropine; D000242:Cyclic AMP; D011188:Potassium; D010646:Phentolamine