Heterogeneity of leukotriene receptors in guinea-pig trachea.
The selective leukotriene (LT) antagonist FPL 55712 antagonized the contractile activity of synthetic LTD4 and E4 on guinea-pig trachea. Schild analysis of the antagonism provided evidence for two distinct receptors for LTD4: one with significantly higher affinity for FPL 55712 than the other. LTE4 appears to interact preferentially with the high affinity receptor.
D000818:Animals; D002867:Chromones / Q000494:pharmacology; D006168:Guinea Pigs; D007700:Kinetics; D017999:Leukotriene E4; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018077:Receptors, Leukotriene; D013189:SRS-A / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014132:Trachea / Q000502:physiology*
D002867:Chromones; D011956:Receptors, Cell Surface; D018077:Receptors, Leukotriene; D013189:SRS-A; D017999:Leukotriene E4; C006312:FPL 55712