Induction of leukemia by both fractionated x-irradiation and radiation leukemia virus involves loci in the chromosome 2 segment H-30-A.
A common link between the induction of leukemia by (i) fractionated doses of x-irradiation and (ii) radiation leukemia virus in mice may be established by the observation that the segment of chromosome 2 between the loci for the minor histocompatibility antigen H-30 and color coat agouti (H-30-A) includes distinct loci involved in susceptibility to leukemogenesis induced by factors i and ii.
D000818:Animals; D002875:Chromosomes / Q000528:radiation effects*; D003433:Crosses, Genetic; D009052:Leukemia Virus, Murine / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000235:genetics* / Q000382:microbiology; D007953:Leukemia, Radiation-Induced / Q000235:genetics* / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity