The Salmonella typhimurium LT2 uvrD gene is regulated by the lexA gene product.
The uvrD gene product apparently plays a role in the repair of UV damage, in mismatch repair, and in genetic recombination. A lower level of expression of the Salmonella typhimurium LT2 uvrD gene was observed in maxicells prepared from an Escherichia coli strain that contained a lexA+ plasmid than in maxicells prepared from an E. coli strain that lacked functional LexA protein. These results suggest that the uvrD+ gene is repressed by the LexA protein and is thus a member of the set of genes whose expression is increased by "SOS"-inducing treatments.
D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology*; D004260:DNA Repair; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D012486:Salmonella typhimurium / Q000235:genetics* / Q000378:metabolism; D012697:Serine Endopeptidases; D014466:Ultraviolet Rays; D000099160:LexA Repressor Protein
D001426:Bacterial Proteins; D012697:Serine Endopeptidases; D000099160:LexA Repressor Protein