In vitro macrophage cytotoxicity of five calcium silicates.
Five calcium silicate minerals (two naturally occurring and three synthetic compounds) with defined morphology and chemical composition were compared for their cytotoxic and lysosomal enzyme releasing effects on unstimulated mouse peritoneal macrophages in vitro. One synthetic material, a fibrous tobermorite, was cytotoxic towards the cells, and two naturally occurring wollastonites induced selective release of beta-glucuronidase from the cells.
D000818:Animals; D017610:Calcium Compounds; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004391:Dust; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D010316:Particle Size; D017640:Silicates; D012824:Silicic Acid / Q000494:pharmacology*; D012822:Silicon Dioxide / Q000494:pharmacology*
D017610:Calcium Compounds; D004391:Dust; D017640:Silicates; D012824:Silicic Acid; D012822:Silicon Dioxide; D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase; C031293:calcium silicate