Inhibition of virus-induced diabetes mellitus by interferon is influenced by the host strain.
The diabetogenic variant of encephalomyocarditis virus (EMC-D) induces a diabetes-like syndrome in certain strains of mice. A study was done to determine if virus-induced diabetes could be prevented by interferon (IFN). It was found that the production of diabetes by EMC-D was blocked by either IFN beta or a variety of IFN-inducers in SWR/J, but not ICR Swiss mice. The replication of EMC-D in cell culture was inhibited by IFN beta. It is concluded that the response of pancreatic beta cells to the protective effect of IFN, is probably under genetic control.
D000818:Animals; D003920:Diabetes Mellitus / Q000209:etiology / Q000235:genetics* / Q000517:prevention & control; D004686:Encephalomyocarditis virus / Q000502:physiology; D004769:Enterovirus Infections / Q000150:complications*; D007369:Interferon Inducers / Q000627:therapeutic use; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011070:Poly I-C / Q000627:therapeutic use; D014779:Virus Replication / Q000187:drug effects
D007369:Interferon Inducers; D007370:Interferon Type I; D011070:Poly I-C