A single-blind comparison of oral and intravaginal treatments in acute and recurrent vaginal candidosis in general practice.
Sixty-three patients with acute or recurrent vaginal candidosis were allocated to treatment with either oral ketoconazole (200 mg twice daily for 5 days) or clotrimazole 100 mg vaginal tablets (one per night for 6 days). Analysis of the results of doctor and patient assessment showed that both treatments were highly effective in reducing the signs and symptoms of infection. Mycological cure rates were similar for both ketoconazole (82%) and clotrimazole (86%). The corresponding mycological relapse rates were 0% and 18%. A significantly higher number of patients expressed a preference for oral treatment (p less than 0.05).
D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003022:Clotrimazole / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D007654:Ketoconazole / Q000008:administration & dosage* / Q000009:adverse effects; D011897:Random Allocation; D013488:Suppositories; D014621:Vagina
D000935:Antifungal Agents; D007093:Imidazoles; D013488:Suppositories; D003022:Clotrimazole; D007654:Ketoconazole