The elimination of sulbactam alone and combined with ampicillin in patients with renal dysfunction.
Sulbactam, a beta-lactamase inhibitor, was given as a single agent to 12 subjects with varying degrees of renal dysfunction. The half-life in normal subjects was 1.1 h and increased to 21.3 h in those with terminal renal failure. Sulbactam together with ampicillin was given to a further five subjects. It was concluded that if the two agents are given together, the plasma ratio of one to the other will remain constant whatever the renal function.
D000667:Ampicillin / Q000008:administration & dosage*; D004338:Drug Combinations; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000378:metabolism*; D013407:Sulbactam
D004338:Drug Combinations; D000667:Ampicillin; D010397:Penicillanic Acid; D013407:Sulbactam