title: Chromosomally competent ovarian failure at adolescence.
abstract: Three female adolescents are presented with delayed or incomplete secondary sexual development due to primary ovarian failure. All three patients had normal blood leukocyte and ovarian tissue karyotypes. The importance of performing a diagnostic laparoscopy with ovarian biopsy in the setting of chromosome competent ovarian failure (CCOF) is emphasized.
mesh_terms: D000293:Adolescent; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004338:Drug Combinations; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D006059:Gonadal Dysgenesis / Q000175:diagnosis*; D006801:Humans; D007621:Karyotyping; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives; D017258:Medroxyprogesterone Acetate; D008594:Menopause, Premature; D008599:Menstruation Disturbances / Q000175:diagnosis* / Q000188:drug therapy; D008656:Mestranol / Q000008:administration & dosage; D009640:Norethindrone / Q000008:administration & dosage; D009641:Norethynodrel / Q000008:administration & dosage; D010050:Ovarian Function Tests; D010053:Ovary / Q000002:abnormalities* / Q000473:pathology; D014424:Turner Syndrome / Q000175:diagnosis
chemical_list: D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; D004966:Estrogens, Conjugated (USP); C014715:Norinyl; C008124:Infecundin; D009641:Norethynodrel; D008656:Mestranol; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D009640:Norethindrone