Concentrations of ceftriaxone in serum and gynecological tissues.
31 patients received an intravenous 15-min injection of 2 g ceftriaxone at various times before abdominal or vaginal hysterectomy. Ceftriaxone concentrations in salpinges were significantly higher than in myometrium and endometrium. Tissue concentrations of 20 micrograms/g could be maintained for at least 5 h. Due to its high tissue concentrations maintained for the whole operative procedure, ceftriaxone does seem to be one of the antibiotics of choice for single-dose prophylaxis of postoperative infections in gynecology.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism*; D001424:Bacterial Infections / Q000517:prevention & control; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D002443:Ceftriaxone; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D002439:Cefotaxime