In vivo release of dopamine in the nucleus accumbens of the rat: modulation by cholecystokinin.
We observed that the release of endogenous dopamine (DA), induced by perfusion of a 55 mM K+-containing buffer in the nucleus accumbens, was Ca2+-dependent and confined to a local region. We also demonstrated that the sulphated form of cholecystokinin octapeptide, but not the unsulphated form, suppressed this stimulated release of dopamine in a concentration-dependent manner. This suggests that cholecystokinin may act as a functional antagonist to dopamine within this structure.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000378:metabolism*; D012844:Sincalide / Q000494:pharmacology*
D012844:Sincalide; D011188:Potassium; D002118:Calcium; D004298:Dopamine