The inhibition of the RNA polymerase activity of influenza virus A by pyrophosphate analogues.
Substituted methylene diphosphonates are effective inhibitors of the RNA polymerase of influenza A virus causing 50% inhibition of the polymerase activity when they are present in the concentration range 10-85 microM. The inhibitory power of the methylene diphosphonates appears to be related to their ability to chelate with metal ions.
D000818:Animals; D002417:Cattle; D004257:DNA Polymerase II / Q000037:antagonists & inhibitors; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D011756:Diphosphates / Q000494:pharmacology; D004164:Diphosphonates / Q000494:pharmacology*; D009980:Influenza A virus / Q000201:enzymology*; D007700:Kinetics; D013329:Structure-Activity Relationship; D013950:Thymus Gland / Q000201:enzymology; D014316:Tritium; D015032:Zinc / Q000494:pharmacology
D011756:Diphosphates; D004164:Diphosphonates; D014316:Tritium; C027474:methylene diphosphonate; D012321:DNA-Directed RNA Polymerases; D004257:DNA Polymerase II; D015032:Zinc