Antiviral activity released from Aedes albopictus cells persistently infected with Semliki forest virus.
Aedes albopictus (mosquito) cells persistently infected with Semliki Forest virus released an agent which inhibited virus production by A. albopictus cells infected with homologous virus. Inhibition of virus production was accompanied by a marked reduction in the synthesis of viral RNA and viral proteins. Expression of the antiviral effect was prevented by pretreatment of cells with actinomycin. No analogous antiviral activity was detected in culture fluids of A. albopictus cells persistently infected with a flavivirus (Kunjin virus) or a bunyavirus (Bunyamwera virus).
D000330:Aedes; D000818:Animals; D000998:Antiviral Agents / Q000502:physiology*; D002042:Bunyamwera virus / Q000254:growth & development; D002460:Cell Line; D005416:Flavivirus / Q000254:growth & development; D012367:RNA, Viral / Q000096:biosynthesis; D012672:Semliki forest virus / Q000254:growth & development* / Q000378:metabolism; D013045:Species Specificity; D014764:Viral Proteins / Q000096:biosynthesis
D000998:Antiviral Agents; D012367:RNA, Viral; D014764:Viral Proteins