title: Chromosome changes in soft tissue sarcomas.
abstract: An analysis of chromosome aberrations in human tumors was performed in 29 cases of soft tissue sarcoma. The tumor tissues were disaggregated with collagenase and the cells cultured for 2-3 days. Analyzable metaphases were obtained in 15 cases, 4 of which showed only normal karyotypes. The remaining 11 tumors showed various numerical and structural abnormalities in their karyotypes: 8 tumors were near-diploid and the remaining 3 were near-triploid. G- and Q-banding analyses revealed clonal abnormalities in the 11 cases with the presence of marker chromosomes; 15 different chromosomes were involved in chromosome rearrangements, chromosomes 1 and 2 being the most frequently affected. Because of the heterogeneity of the tumor group investigated (neurogenic sarcoma, 2 liposarcomas, neurofibrosarcoma, synovial cell sarcoma, fibrosarcoma, mesothelioma, leiomyosarcoma, rhabdomyosarcoma, Ewing's sarcoma, and hemangiopericytoma), it was impossible to reach any conclusion on the specificity of the cytogenetic abnormalities for a particular tumor type.
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D005260:Female; D005354:Fibrosarcoma / Q000235:genetics; D006801:Humans; D007890:Leiomyosarcoma / Q000235:genetics; D008080:Liposarcoma / Q000235:genetics; D008297:Male; D008654:Mesothelioma / Q000235:genetics; D008677:Metaphase; D008875:Middle Aged; D009455:Neurofibroma / Q000235:genetics; D012509:Sarcoma / Q000235:genetics*; D012512:Sarcoma, Ewing / Q000235:genetics; D013584:Sarcoma, Synovial / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000235:genetics*