[Experimental studies on the enhancing effects of the combined therapy with tegafur and cytochrome C].
Coadministration of Tegafur and cytochrome C produced higher concentration of an active substance, 5-FU, in the blood of normal rats as compared with Tegafur alone. However, there was no difference between the combination regimen and Tegafur alone in LD50. Blood and tumor levels of 5-FU in tumor-bearing rats were higher in the combination than Tegafur alone, and survival effects were more favorable in the former. On the other hand, cytochrome C prohibited decrease in the amount of liver P-450 induced by carbon tetrachloride.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D003574:Cytochrome c Group / Q000008:administration & dosage* / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000031:analogs & derivatives*; D007928:Lethal Dose 50; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D005641:Tegafur / Q000008:administration & dosage* / Q000494:pharmacology
D003574:Cytochrome c Group; D005641:Tegafur; D005472:Fluorouracil