Self-associating IgG rheumatoid factors stimulate monocytes to release prostaglandins and mononuclear cell factor that stimulates collagenase and prostaglandin production by synovial cells.
Self-associating IgG rheumatoid factors isolated from three patients with rheumatoid arthritis activated human monocytes to release prostaglandin E2 as well as a previously described mononuclear cell factor, which stimulates human synovial cells to release additional prostaglandin E2 and collagenase. Thus, the immune complexes composed of self-associating IgG rheumatoid factors can contribute to the processes that destroy cartilage and bone in patients with rheumatoid arthritis.
D006801:Humans; D007074:Immunoglobulin G / Q000494:pharmacology*; D003012:Microbial Collagenase / Q000096:biosynthesis*; D009000:Monocytes / Q000378:metabolism*; D015846:Monokines; D011458:Prostaglandins E / Q000096:biosynthesis / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012217:Rheumatoid Factor / Q000494:pharmacology*; D013583:Synovial Membrane / Q000166:cytology / Q000378:metabolism*
D007074:Immunoglobulin G; D015846:Monokines; D011458:Prostaglandins E; D011506:Proteins; D012217:Rheumatoid Factor; D003012:Microbial Collagenase