title: Virus specific antigens in BK virus-transformed cells detected by cell-mediated immune reactions.
abstract: Mouse cell lines transformed by BK virus (BKV) were used for immunizations and as targets in the 51Cr release assay to detect BKV specific cell surface antigens. When BKV-transformed cells from C57BL/6J mice were used to immunize syngeneic animals and the effector cells were stimulated in vitro, cytotoxic lymphocytes were generated which lysed syngeneic BKV-transformed cells but not control cells transformed by UV irradiation or 3-methylcholanthrene. The reaction was apparently H-2-restricted. A cross reaction was observed between cell lines transformed by BKV or SV40. The BKV specific antigen detected by the cell-mediated immune reaction presumably corresponds to the tumour specific transplantation antigen previously detected in BKV-transformed cells.
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D000957:Antigens, Viral, Tumor; D001739:BK Virus / Q000276:immunology* / Q000502:physiology; D002460:Cell Line; D002472:Cell Transformation, Viral; D003602:Cytotoxicity, Immunologic; D006649:Histocompatibility Antigens / Q000032:analysis*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011120:Polyomavirus / Q000276:immunology*; D013539:Simian virus 40 / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000957:Antigens, Viral, Tumor; D006649:Histocompatibility Antigens; C029237:tumor-associated transplantation antigen