Peripheral nerve conduction studies in galactose-poisoned rats. Demonstration of increased resistance to ischemic conduction associated with endoneurial edema due to sugar alcohol accumulation.
Edematous nerves of galactose-poisoned rats had an increased resistance to ischemic conduction block when compared with control animals. Ischemia was caused by cardiac arrest due to intracardiac air embolism in 1 group and by occlusion of the abdominal aorta in another. In these 2 groups of galactose-fed rats, time to 50% conduction block was increased by 27 and 42%, respectively and the difference between control and galactose rats was significant (P less than 0.01 and P less than 0.001).
D000818:Animals; D001018:Aortic Diseases / Q000503:physiopathology; D003251:Constriction, Pathologic; D004487:Edema / Q000209:etiology*; D004618:Embolism, Air / Q000503:physiopathology; D005690:Galactose / Q000506:poisoning*; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D009407:Nerve Block; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013402:Sugar Alcohols / Q000378:metabolism*
D013402:Sugar Alcohols; D005690:Galactose