Comparison of some biological properties of neurotensin and its natural analogue LANT-6.
The biological properties of neurotensin (NT) and the chicken peptide [Lys8,Asn9]neurotensin-(8-13) (LANT-6) were compared in 3 in vitro assays: (1) competitive inhibition of [3H]NT binding to rat brain synaptic membranes, (2) relaxation of the rat ileum, and (3) contraction of the guinea-pig ileum. The data show that LANT-6 interacted with NT receptors like a weak agonist having full intrinsic activity and low affinity. LANT-6 is unlikely to represent a physiological activator of NT receptors.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D002645:Chickens; D006168:Guinea Pigs; D007082:Ileum / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology; D009496:Neurotensin / Q000502:physiology*; D009842:Oligopeptides / Q000502:physiology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D018028:Receptors, Neurotensin
D009842:Oligopeptides; D011956:Receptors, Cell Surface; D018028:Receptors, Neurotensin; D009496:Neurotensin; C037243:neurotensin-related hexapeptide