title: Polycation-induced alterations of the envelope surface of influenza and parainfluenza viruses.
abstract: Natural macromolecular polycations (protamine, histones H1, H2A, H2B and H3) caused the clustering of influenza and parainfluenza viruses into aggregates heterogeneous in size, as well as a decrease in their hemagglutinating capacity. Polycation-induced virus alterations consisted in surface pyknosis and an increase most efficient as regards the interaction with viruses.
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006387:Hemagglutination, Viral / Q000187:drug effects*; D006657:Histones / Q000494:pharmacology*; D009980:Influenza A virus / Q000187:drug effects / Q000502:physiology*; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects / Q000502:physiology*; D011479:Protamines / Q000494:pharmacology*; D013499:Surface Properties
chemical_list: D006657:Histones; D011479:Protamines