[Anti-tumor activity of the polysaccharide mannan, and its effect on the dynamics of cyclic nucleotides in tissue].
Mice with transplantable Harding-Passey melanoma were treated with polysaccharide mannan (50 mg/kg), cyclophosphamide (20 and 100 mg/kg) and their combinations. Mannan proved to possess considerable antitumor properties. It potentiated the therapeutic effect of cyclophosphamide and diminished its toxicity. Mannan treatment resulted in two-phase dynamics of cyclic nucleotide system in mouse liver and melanoma.
D000818:Animals; D000970:Antineoplastic Agents; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D003520:Cyclophosphamide / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D008099:Liver / Q000378:metabolism; D008351:Mannans / Q000008:administration & dosage / Q000494:pharmacology*; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011134:Polysaccharides / Q000494:pharmacology*
D000970:Antineoplastic Agents; D008351:Mannans; D009712:Nucleotides, Cyclic; D011134:Polysaccharides; D003520:Cyclophosphamide; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D006152:Cyclic GMP
Protivoopukholevaia aktivnost' polisakharida mannana i ego vliianie na dinamiku tsiklicheskikh nukleotidov v tkaniakh.