Effect of aligeron and cinnarizine in models of general and local depression of the cortical bioelectrical activity in cats.
The effect of aligeron (5 mg/kg i.v.) and cinnarizine (10 mg/kg i.v.) on general and local depression of cortical bioelectrical activity was studied in acute experiments on cats. Asphyxic anoxia and hypoventilation hypoxia were used as models of general depression. Local depressions were caused by topical application of potassium chloride (KCl) and adenosine-5'-monophosphate (AMP) on the cortex. In hypoventilation hypoxia aligeron and cinnarizine increased cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions the drugs showed a protective effect manifested in a decrease of the degree and duration of the depression. In asphyxic anoxia their effect was insignificant.
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects*; D002936:Cinnarizine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D004569:Electroencephalography; D005260:Female; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D010879:Piperazines; D014665:Vasodilator Agents; D002936:Cinnarizine; D011189:Potassium Chloride; C021591:Aligeron; D000242:Cyclic AMP