Effects of arotinoids upon murine embryonal carcinoma cells.
Five arotinoids have been compared with all-trans- and 13-cisretinoic acids for their ability to promote differentiation of cells from murine embryonal carcinoma line Nulli-SCC1. Ro-13-7410, which contains a terminal carboxylic acid residue, and Ro-14-9572, the sodium sulfinate derivative, are potent inducers of differentiation. The sodium sulfonate derivative, Ro-14-3899, is somewhat less active, whereas the ethyl sulfone (Ro-15-1570) and Ro-15-0778, an arotinoid lacking a terminal group, have little or no effect on embryonal carcinoma cell differentiation. Competition by the arotinoids with all-trans-retinoic acid for sites on the cellular retinoic acid-binding protein is qualitatively consistent with their capacity for promoting differentiation. This relationship and the response of differentiation-defective embryonal carcinoma cells to Ro-13-7410 support the view that arotinoids and retinoids promote differentiation of embryonal carcinoma cells via the same mechanism.
D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D002352:Carrier Proteins / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D007536:Isomerism; D007700:Kinetics; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000503:physiopathology; D018168:Receptors, Retinoic Acid; D012176:Retinoids; D013329:Structure-Activity Relationship; D013724:Teratoma / Q000503:physiopathology*; D014212:Tretinoin / Q000378:metabolism; D014801:Vitamin A / Q000494:pharmacology*
D001565:Benzoates; D002352:Carrier Proteins; D009363:Neoplasm Proteins; D018168:Receptors, Retinoic Acid; D012176:Retinoids; D014801:Vitamin A; D014212:Tretinoin; C038864:4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid