Unsuccessful DTIC treatment of a patient with glucagonoma syndrome.
Various chemotherapeutic modalities have been tried in the treatment of patients with malignant glucagonomas. Promising results have been reported after drug treatment with dimethyltriazenoimidazole carboxamide (DTIC). We present a patient with a metastasizing pancreatic glucagonoma, in whom treatment with neither DTIC nor with the combination of streptozotocin and 5-fluorouracil resulted in any noticeable improvement.
D007516:Adenoma, Islet Cell / Q000188:drug therapy*; D003606:Dacarbazine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use; D005935:Glucagonoma / Q000188:drug therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D013311:Streptozocin / Q000627:therapeutic use
D013311:Streptozocin; D003606:Dacarbazine; D005472:Fluorouracil