Microsomal P-450 induction by some secondary products from thermal oxidation of dietary lipids: epidermal hyperplasia, mutagenicity and cytochrome P-450 activities.
Distillable secondary products from roasted fowl were found to be cytotoxic but not mutagenic when assayed with Salmonella typhimurium strains TA98, TA100 and TA1537. A crudely separated fraction of the volatiles produced focal hyperplasia and damage to the epidermis of the backs of mice. The volatiles also caused an apparent synthesis of non-constitutive forms of rat hepatic cytochromes P-450 which metabolize benzo[a]pyrene B [a]P differently from the constitutive P-450.
D000287:Administration, Topical; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism; D002273:Carcinogens; D002645:Chickens; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage*; D004790:Enzyme Induction; D005260:Female; D006358:Hot Temperature; D007274:Injections, Intraperitoneal; D008297:Male; D008460:Meat; D008461:Meat Products; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D009152:Mutagenicity Tests; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D012871:Skin Diseases / Q000209:etiology
D001580:Benzopyrenes; D002273:Carcinogens; D004041:Dietary Fats; D001564:Benzo(a)pyrene; D003577:Cytochrome P-450 Enzyme System