title: Chronic in vivo treatment with desmethylimipramine and mianserin does not alter adenosine A-1 radioligand binding in rat cortex.
abstract: Antidepressants and electroconvulsive shock therapy (ECS) have been reported to alter adenosine-sensitive adenylate cyclase responses in rat brain, suggesting an involvement of the purine in the mechanisms by which antidepressants and antidepressant therapy produce their clinical effects. Chronic (14-21 days, 10 mg/kg/day by Alzet minipump) treatment with desmethylimipramine (DMI) and mianserin, while producing changes in beta-adrenoceptor (DMI) and serotonin-2 (DMI and mianserin) radioligand binding similar to those reported in the literature, has no effect on adenosine A-1 radioligand binding.
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D003891:Desipramine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D008297:Male; D008566:Membranes / Q000378:metabolism; D008803:Mianserin / Q000494:pharmacology*; D011869:Radioligand Assay; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D013997:Time Factors
chemical_list: D003984:Dibenzazepines; D011943:Receptors, Adrenergic, beta; D008803:Mianserin; C027513:N(6)-cyclohexyladenosine; D000241:Adenosine; D003891:Desipramine