[Effects of electric stimulation of the para-ventricular nucleus on corticotropin function in Long-Evans and Brattleboro rats].
Two peptides have a strong corticotropin releasing factor (CRF) activity: arginine vasopressine (AVP) and a 41-residue peptide (41-CRF). Both peptides are present in high concentration in the PVN of the Rat, a zone of the hypothalamus at which electrical stimulation elicits ACTH release. Since homozygous Brattleboro Rats (Di/Di) congenitally lack endogenous AVP, it was of interest to compare the ACTH and corticosterone release after electrical stimulation of the PVN in Long-Evans (L.E.) and Di/Di Rats. In both L.E. and Di/Di Rats, there is a significant increase in plasma ACTH and corticosterone after electrical stimulation of the PVN. However, corticosterone levels are significantly lower in Di/Di than in L.E. Rats whether the Rats have been stimulated or not. It is concluded that a physiological CRF activity is present in the PVN of Di/Di Rats independently of the CRF like activity of AVP.
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D004558:Electric Stimulation; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D003345:Corticosterone
Effets de la stimulation électrique du noyau para-ventriculaire (PVN) sur la fonction corticotrope du rat Long-Evans et Brattleboro.