Development of tolerance and cross-tolerance to the cataleptogenic effects of delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol in mice.
Tolerance developed to the cataleptogenic effects of delta 8-tetrahydrocannabinol (delta 8-THC) and 11-hydroxy-delta 8-THC on daily administration (5 mg/kg per day i.v.) of these substances in mice. Reciprocal cross-tolerance was also demonstrated between both cannabinoids. The ED50S (mg/kg i.v.) for delta 8-THC and 11-hydroxy-delta 8-THC were 13.0 (10.2-16.5) and 5.3 (3.4-8.2), respectively, in delta 8-THC-tolerant mice (7 days' treatment) while the corresponding ED50S were 20.8 (17.6-24.5) and 11.7 (8.5-15.7), respectively, in 11-hydroxy-delta 8-THC-tolerant mice. These values were much higher than those in the vehicle-treated mice [delta 8-THC, 4.1 (2.8-5.9); 11-hydroxy-delta 8-THC, 0.98 (0.53-1.81)].
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D051379:Mice
C020367:11-hydroxy-delta(8)-tetrahydrocannabinol; C035731:delta-8-tetrahydrocannabinol; D013759:Dronabinol