Potassium accumulation in the frog spinal cord induced by nociceptive stimulation of the skin.
Changes of extracellular K+ concentration (delta[K]e) were studied in the frog spinal cord in response to noxious skin stimulation by hot water (55-65 degrees C). The magnitude of delta[K]e was dependent on the duration and the extent of the skin area heated. The maximum of delta[K]e (0.2-1.0 mmol X 1(-1)) occurred in the dorsal horn at about the same location where the highest increase of [K]e was observed in response to electrical stimulation of the skin. The nociceptive as well as electrical stimulation of contralateral hindlimb resulted in delta[K]e, which was about 50% of that observed during ipsilateral stimulation.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials; D007839:Functional Laterality / Q000502:physiology; D005727:Ganglia, Spinal / Q000502:physiology; D006614:Hindlimb / Q000294:innervation; D009474:Neurons / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D011893:Rana esculenta; D011896:Rana temporaria; D012867:Skin / Q000294:innervation*; D013116:Spinal Cord / Q000502:physiology*; D009435:Synaptic Transmission; D013697:Thermosensing / Q000502:physiology
D011188:Potassium