Signet-ring cell variant of large cell lymphoma.
A diffuse, large cell lymphoma of palatine tonsil was found to contain a considerable number of enlarged tumor cells with prominent, hyaline, Russell body-type cytoplasmic inclusions displacing the nucleus peripherally and, thus, the morphologic features of signet-ring cell lymphoma. Immunoperoxidase staining revealed that the contents of the signet-ring cells were strongly positive for mu heavy chains and kappa light chains. Ultrastructurally, Russell body-type inclusions consisted of multiple, angulated, electron-dense crystalloids enclosed within expanded segments of rough endoplasmic reticulum.
D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000302:isolation & purification; D007148:Immunoglobulin mu-Chains / Q000302:isolation & purification; D002479:Inclusion Bodies / Q000648:ultrastructure; D008223:Lymphoma / Q000145:classification / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000473:pathology* / Q000648:ultrastructure; D014067:Tonsillar Neoplasms / Q000145:classification / Q000473:pathology* / Q000648:ultrastructure
D007075:Immunoglobulin M; D007148:Immunoglobulin mu-Chains