The role of central serotoninergic neurotransmission in the morphine abstinence syndrome in rats.
It was found that 200 mg/kg of DL-p-chlorophenylalanine (PCPA) and 2 mg/kg of methergoline drugs inhibiting central serotoninergic transmission-decreased naloxone precipitated abstinence wet dog shakes in morphine-dependent rats. The inhibitory effect of PCPA was reversed by 200 mg/kg of 5-hydroxy-L-tryptophan (5-HTP) but not by the same amount of L-tryptophan (TP). 5-HTP alone (200 mg/kg) increased wet dog shakes epissodes, whereas TP alone in the same dosage practically did not have any influence on the wet dog shakes in morphine-dependent rats. These findings suggest that brain serotonin may play some role in the expression of wet dog shakes in morphine-dependent rats.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D009020:Morphine / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013375:Substance Withdrawal Syndrome / Q000209:etiology* / Q000517:prevention & control; D009435:Synaptic Transmission; D014364:Tryptophan / Q000494:pharmacology
D008711:Metergoline; D012701:Serotonin; D009020:Morphine; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D010134:Fenclonine