Hirano-bodies in the distal symmetric polyneuropathy of the spontaneously diabetic BB-Wistar rat.
Lattice-like cytoplasmic inclusions have been demonstrated in a variety of pathologic conditions of the CNS and PNS in both man and animals. We describe 2 types of such inclusions occurring in association with the distal central-peripheral symmetric polyneuropathy of the spontaneously diabetic BB-Wistar rat. In the literature, both these lattice-like inclusions have been referred to as Hirano-bodies, but have not been separated on the basis of different measurements, locations or possible origins.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000473:pathology*; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D009836:Oligodendroglia / Q000648:ultrastructure; D010525:Peripheral Nerves / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains