title: Surgical treatment of carcinoma of the breast. I. Pathological finding and pattern of relapse.
abstract: This is a retrospective review of 476 patients who had mastectomy for carcinoma of the breast during 1971-1980. There is a positive correlation of size of the primary tumor and the incidence of axillary nodal metastasis. Infiltrating ductal and lobular carcinoma had a significantly higher incidence of nodal metastasis (and greater change of having four or more positive nodes) than that of medullary and colloid carcinomas. Colloid carcinoma smaller than 4 cm and the less common histological subtypes (comedo, tubular, papillary carcinomas) rarely metastasizes. At a median follow-up time of 53 months, 23% of patients with infiltrating ductal, lobular, or medullary carcinomas and who did not have nodal metastasis had relapse, while 50% of those with nodal involvement had relapse. Among those who relapsed, 18% initially had only locoregional recurrence, 60% had distant metastasis, and 22% had both types.
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002277:Carcinoma / Q000473:pathology / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies