[Protective action of double-stranded complexes--interferon inducers in encephalomyocarditis in mice].
Interferon inducers, dsRNA and poly (G) X poly (C) ( polyguacyl ), injected into mice intraperitoneally induced interferon formation, the maximal activity being equal to 640-1280 U/ml. Antiviral effect of the inducers was studied upon intraperitoneal and intracerebral injections. Both polyguacyl and dsRNA exerted a marked antiviral action against infection induced by murine encephalomyocarditis virus. The most powerful effect was attained when the inducers were injected 24 or 4 h before challenge. The protective action was produced by polyguacyl and dsRNA even after intracerebral infection. There is a good agreement between the interferon-inducing and antiviral activity of interferon inducers. The data obtained demonstrate the fitness of experimental encephalomyocarditis of mice for testing interferon inducers.
D000818:Animals; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000517:prevention & control*; D007369:Interferon Inducers / Q000627:therapeutic use*; D051379:Mice; D011066:Poly C / Q000627:therapeutic use*; D011068:Poly G / Q000627:therapeutic use*; D011131:Polyribonucleotides / Q000627:therapeutic use*; D012330:RNA, Double-Stranded / Q000627:therapeutic use*
D007369:Interferon Inducers; D011131:Polyribonucleotides; D012330:RNA, Double-Stranded; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C
Zashchitnoe deĭstvie dvunitevykh kompleksov--induktorov interferona pri éntsefalomiokardite mysheĭ.