title: [Association of mixed connective tissue disease with Sjogren's syndrome and lupus in 2 HLA- and DR-identical sisters].
abstract: Different connective tissue diseases were observed in two HLA--and DR--identical sisters. The daughter of one of the index patients and their father exhibited closely related symptoms. With reference to this familial observation the authors discuss the significance of DR3 which is correlated with immunologic disturbances producing multiple clinical and biological manifestations.
mesh_terms: D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000235:genetics / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000235:genetics / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II
vernacular_title: Association d'une connectivite mixte avec syndrome de Sjögren et d'une maladie lupique chez deux sceurs HLA ET DR identiques.