Interaction of naloxone with the opioid receptor complex in vitro.
Previous work from this laboratory suggests that distinct morphine and enkephalin receptors coexist in an opioid receptor complex. In this paper the interaction of naloxone with the receptor complex is studied. The results further strengthens the hypothesis that leucine enkephalin binds poorly to the morphine receptor and that morphine and enkephalin receptors are allosterically coupled.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008433:Mathematics; D009020:Morphine / Q000378:metabolism; D009270:Naloxone / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism*
D011957:Receptors, Opioid; D009270:Naloxone; D004743:Enkephalin, Leucine; D009020:Morphine