Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors.
Regional blood flow (F) was measured in avian sarcoma virus (ASV)-induced brain tumors in rats. Blood flow was variable in individual as well as different tumors; tumor F did not correlate with histologic classification, tumor size, central versus peripheral tumor regions, intraparenchymal location, cell density, or specific cytologic characteristics. Low values of F did correlate with tumor necrosis and hydrocephalus; high values of F correlated with tumorous invasion or association with choroid plexus. Mean tumor F was not significantly different from that of the same anatomic, tumor-free brain region of the contralateral hemisphere, but F in brain tissue adjacent to the tumor was depressed significantly. Depression of F was observed in tumor-free cortex and corpus callosum, especially in the hemisphere ipsilateral to the main tumor mass and in those animals with hydrocephalus.
D000818:Animals; D001254:Astrocytoma / Q000098:blood supply; D001932:Brain Neoplasms / Q000098:blood supply*; D051381:Rats; D011916:Rats, Inbred F344; D012039:Regional Blood Flow; D001357:Sarcoma, Avian / Q000098:blood supply*