title: Activation and inactivation of synthesis of secondary wall polymers in Bacillus subtilis W23.
abstract: The progress of activation and inactivation of synthesis of the wall polymers, teichoic acid and teichuronic acid, in response to changes in the phosphate content of the growth medium has been examined using toluenised cells of B. subtilis W23. Activation of teichoic acid synthesis from nucleotide precursors was independent of protein synthesis, but chloramphenicol prevented activation when DL-glycerol 3-phosphate and CTP replaced CDP-glycerol as one of the substrates of the reaction. Activation of teichuronic acid synthesis was dependent on synthesis of protein. Inactivation of synthesis of both polymers was slowed, but not prevented, by inhibition of protein synthesis. Evidence was obtained that a protein synthesised during phosphate starvation retards the activation of teichoic acid synthesis.
mesh_terms: D001412:Bacillus subtilis / Q000378:metabolism* / Q000648:ultrastructure; D001426:Bacterial Proteins / Q000096:biosynthesis; D002473:Cell Wall / Q000378:metabolism*; D004734:Energy Metabolism; D009713:Nucleotidyltransferases / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000378:metabolism*; D013682:Teichoic Acids / Q000096:biosynthesis
chemical_list: D001426:Bacterial Proteins; D010710:Phosphates; D011135:Polysaccharides, Bacterial; D013682:Teichoic Acids; D009713:Nucleotidyltransferases; C032634:D-ribitol-5-phosphate cytidylyltransferase