The effect of hexadimethrine bromide (polybrene) on the infection of the primate retroviruses SSV 1/SSAV 1 and BaEV.
Polybrene was shown to enhance the adsorption of simian sarcoma virus-simian sarcoma associated virus complex (SSV-1/SSAV-1) and baboon endogenous virus (BaEV) onto cells in culture. A 16- to 18-fold increased adsorption of both viruses occurred at 8 micrograms/ml polybrene within one hour after infection. The polybrene mediated adsorption was found to be inhibited by the addition of tri-sodium citrate to the culture medium, suggesting the involvement of electrostatic forces. This contention was further supported by the demonstration of temperature independence of the polybrene mediated interaction.
D000327:Adsorption; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D004305:Dose-Response Relationship, Drug; D006583:Hexadimethrine Bromide / Q000494:pharmacology*; D011073:Polyamines / Q000494:pharmacology*; D012190:Retroviridae / Q000187:drug effects* / Q000502:physiology; D012842:Sarcoma Virus, Woolly Monkey / Q000187:drug effects / Q000502:physiology; D012526:Satellite Viruses / Q000187:drug effects / Q000502:physiology; D013696:Temperature
D002951:Citrates; D011073:Polyamines; D019343:Citric Acid; D006583:Hexadimethrine Bromide