[Acquired hypogammaglobulinemia and malabsorption with villous atrophy sensitive to a gluten-free diet].
The observation of a 21 year-old man with primary common variable hypogammaglobulinemia and total villous atrophy is reported. Gluten withdrawal induced considerable improvement in malabsorption and mucosal damage. However, protein-losing enteropathy, nodular lymphoid hyperplasia and immunoglobulin deficiency were persistent. To our knowledge, improvement on gluten-free diet has been reported until now in 18 previous cases. This report illustrates the links between immunodeficiency and malabsorption, which are discussed.
D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications*; D004044:Dietary Proteins / Q000008:administration & dosage; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007421:Intestine, Small / Q000473:pathology*; D008286:Malabsorption Syndromes / Q000178:diet therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008297:Male; D013997:Time Factors
D004044:Dietary Proteins; D005983:Glutens
Hypogammaglobulinémie acquise et malabsorption avec atrophie villositaire sensible au régime sans gluten.