[Relation between the inhibitory effect on the synthesis of the rabbit aorta contracting substance and prostaglandins and the anti-inflammatory activity of ketoprofen and other non-steroidal anti-inflammatory agents].
This study showed that, relative to the other antiinflammatory drugs studied, ketoprofen is a stronger inhibitor of the synthesis of prostaglandins and Rabbit aorta Contracting Substance ("RCS") by guinea pig lung tissue in vitro. Although there seems to be no close correlation between their potency as inhibitors of prostaglandin synthesis and their effectiveness as antiinflammatory agents, evaluation of both activities results in classification of the drugs in the same order.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000494:pharmacology; D008168:Lung / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013931:Thromboxanes / Q000096:biosynthesis*
D000893:Anti-Inflammatory Agents; D011453:Prostaglandins; D013931:Thromboxanes; D013928:Thromboxane A2; D007660:Ketoprofen
Relations entre l'activité inhibitrice sur la synthèse de la "Rabbit aorta Contracting Substance" et des prostaglandines et l'activité anti-inflammatoire du kétoprofène et de quelques autres anti-inflammatoires non stéroïdiens.