Radioprotection of the rat parotid gland by cAMP.
Most earlier studies showing a radioprotective effect by cAMP show only slight degrees of protection. The present study demonstrates a substantial protective effect (DMF, 1.63) of exogenously administered cAMP on the rat parotid gland and supports the mechanism suggested previously for protection afforded the parotid glands by the beta-adrenergic agonist isoproterenol, which is known to elevate endogenous intracellular cAMP.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D005260:Female; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D010306:Parotid Gland / Q000187:drug effects* / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011837:Radiation-Protective Agents; D003994:Bucladesine