Prenatal amphetamine reduces alpha but not beta adrenergic receptor binding in brain of adult rats.
Adult offspring of rats treated with daily injection of d, 1-amphetamine sulfate (0.5 mg/kg s.c.) during pregnancy showed a significant decrease in brain alpha but not beta adrenergic receptor binding, without apparent changes in receptor affinity. This change may be a consequence of long lasting alterations in the metabolism of brain catecholamines produced by amphetamine administration at fetal age, and may account for the behavioral alterations described in these animals.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D000661:Amphetamine