Reduced spinal reflexes following intrathecal baclofen in the rabbit.
Intrathecal baclofen is effective in reducing polysynaptic spinal reflexes in awake rabbits. A single lumbar infusion of 2.5-5.0 ng drug caused a significant reduction in the crossed extensor response to electrical stimulation of the plantar surface of the hindlimb. This inhibition lasted 5 h or more. At doses of 3 micrograms or less, the forelimbs were unaffected.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006614:Hindlimb / Q000294:innervation; D007278:Injections, Spinal; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011817:Rabbits; D011930:Reaction Time / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D001418:Baclofen