Neutrophil aggregating properties of PAF-acether and leukotriene B4.
Both leukotriene B4 (LTB4) and platelet activating factor (PAF-acether) induce the aggregation of rat polymorphonuclear leucocytes. PAF-acether, but not LTB4, causes the aggregation of washed rabbit platelets. The results obtained from cross-desensitisation studies and experiments using inhibitors of arachidonic acid metabolism support the concept that LTB4 and PAF-acether have separate receptor sites on the neutrophil cell surface and show that PAF-acether does not induce neutrophil aggregation by releasing LTB4.
D015117:5,8,11,14-Eicosatetraynoic Acid / Q000494:pharmacology; D000818:Animals; D002396:Catechols; D002449:Cell Aggregation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000494:pharmacology; D007975:Leukotriene B4 / Q000494:pharmacology*; D008297:Male; D009637:Masoprocol; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D002396:Catechols; D010972:Platelet Activating Factor; D015117:5,8,11,14-Eicosatetraynoic Acid; D007975:Leukotriene B4; D009637:Masoprocol; D007213:Indomethacin