Chronic effects of dietary exposure to amosite and chrysotile asbestos in Syrian golden hamsters.
Bioassays of amosite, short-range (SR), intermediate-range (IR) or intermediate-range chrysotile asbestos in combination with the intestinal carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) were conducted with male and female Syrian golden hamsters. Amosite and both forms of chrysotile asbestos were administered at a concentration of 1% in pelleted diet for the entire lifetime of the hamsters starting with mothers of the test animals. Group sizes varied from 125-254. There was no adverse effect on body weight gain or survival by either type of asbestos or by IR chrysotile asbestos in combination with DMH. A significant increase (p less than 0.05) in adrenal cortical tumors was observed in male hamsters exposed to SR and IR chrysotile asbestos and in females treated with IR chrysotile asbestos when compared to the pooled control groups. However, statistical significance (p less than 0.05) was lost when these dosed groups were compared with temporal control groups. Neither of the male or female amosite asbestos groups showed increased neoplasia in any tissue or organ compared to the control groups. The cocarcinogen studies using IR chrysotile asbestos and 1,2-dimethylhydrazine dihydrochloride were considered inadequate because there was no increase in intestinal neoplasia in the DMH group.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001194:Asbestos / Q000008:administration & dosage / Q000633:toxicity*; D017639:Asbestos, Amosite; D017632:Asbestos, Serpentine; D001835:Body Weight; D003043:Cocarcinogenesis; D006224:Cricetinae; D004032:Diet; D004127:Dimethylhydrazines; D005260:Female; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000209:etiology*; D013997:Time Factors
D017632:Asbestos, Serpentine; D004127:Dimethylhydrazines; D017639:Asbestos, Amosite; D001194:Asbestos; D019813:1,2-Dimethylhydrazine