title: Responses of specific-pathogen-free chicks to concomitant infections of reovirus (WVU-2937) and infectious bursal disease virus.
abstract: Specific-pathogen-free white leghorn chicks concomitantly infected with both infectious bursal disease virus (IBDV) and reovirus (WVU-2937) on day 1 had significantly lower (P less than 0.05) virus-neutralizing- and precipitating-antibody geometric mean titers (GMT) to reovirus than chicks infected with only reovirus on day 1 but had a similar incidence of inflammation of the metatarsal digital flexor tendons. Chicks infected with IBDV on day 7 and reovirus on day 14 had a greater incidence of inflammation of the tarsometatarsal digital flexor tendons and lower neutralizing- and precipitating-antibody GMT to reovirus than chicks infected with only reovirus on day 14. Chicks infected with both viruses on day 1 had a significantly lower (P less than 0.05) neutralizing-antibody GMT to IBDV than chicks infected with only IBDV.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002645:Chickens; D007243:Infectious bursal disease virus / Q000276:immunology; D009500:Neutralization Tests; D011201:Poultry Diseases / Q000276:immunology / Q000473:pathology*; D011233:Precipitin Tests / Q000662:veterinary; D012087:Reoviridae / Q000276:immunology; D012088:Reoviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013710:Tendons / Q000473:pathology
chemical_list: D000914:Antibodies, Viral