Production of positively supercoiled DNA by netropsin.
The antibiotic netropsin binds to DNA by a non-intercalative mechanism. It increases the linking number of DNA so that in the presence of topoisomerase I, positively supercoiled molecules are produced.
D001665:Binding Sites; D002738:Chloroquine; D004278:DNA, Superhelical / Q000096:biosynthesis*; D004587:Electrophoresis, Agar Gel; D006146:Guanidines / Q000494:pharmacology*; D009429:Netropsin / Q000494:pharmacology*
D004278:DNA, Superhelical; D006146:Guanidines; D009429:Netropsin; D002738:Chloroquine