title: Spin label studies on synaptosomal membranes of rat brain cortex during aging.
abstract: Membrane lipids of brain synaptosomes of 2, 12 and 24 months old rats were labeled by stearic acid spin probes with a doxyl group in the C-5 and C-16 position, respectively. We demonstrated that the hydrophobic region of synaptosomal membranes became more rigid during the life span studied, and the region located nearer the surface of membranes displays a significantly decreased fluidity only in the oldest group. Membrane proteins labeled with a nitroxide derivative of maleimide suggest that conformational changes take place during aging.
mesh_terms: D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D008563:Membrane Lipids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins