title: [Evaluation of the analgesic effect of UP 341-01 in patients presenting with acute pain in ORL].
abstract: The authors report the results obtained with a new analgesic, UP 341.01, which is a bioprecursor of paracetamol. Two groups of patients with acute pain, due to suppurative acute otitis media before myringotomy, were given an intravenous injection of 1 or 2 g of UP 341.01 respectively. Changes in the severity of pain were assessed over five hours by means of a verbal five point scoring system. During this study, UP 341.01 proved efficient and well tolerated.
mesh_terms: D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000208:Acute Disease; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010033:Otitis Media / Q000503:physiopathology*; D010035:Otitis Media, Suppurative / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000700:Analgesics; C039197:UP 341,01; D000082:Acetaminophen
vernacular_title: Evaluation de 'activité antalgique de l'UP 341.01 chez des patients présentant une douleur aiguë en O.R.L.