The adenosine agonist 2-chloroadenosine inhibits the induction of long-term potentiation of the perforant path.
The effect of 2-chloroadenosine (5 and 10 microM) on long-term potentiation of the perforant path has been investigated. Experiments were performed in vivo using a push-pull cannula implanted in the dentate gyrus. A high intensity, high frequency train applied to the perforant path during perfusion with the adenosine agonist 2-chloroadenosine, was markedly attenuated in its ability to produce long-term potentiation. Inhibitory effects on pre- and post-synaptic calcium calcium influx are discussed.
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003864:Depression, Chemical; D005071:Evoked Potentials / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects; D007473:Ion Channels / Q000502:physiology; D008032:Limbic System / Q000187:drug effects*; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D007473:Ion Channels; D015762:2-Chloroadenosine; D000241:Adenosine; D002118:Calcium