N-(functionalized alkyl) derivatives of 6-aminopenicillanic acid: a new series of specific inhibitors of beta-lactamase from Enterobacter cloacae P99.
Eight of nine new N-alkylaminopenicillanic acids (7a approximately c, e approximately j), prepared via efficient direct monoalkylation reactions, were found to be specific inhibitors of cephalosporinase P99 with IC50 less than or equal to 4 mg/liter, while representative corresponding S-oxidized derivatives were less active.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D004755:Enterobacteriaceae / Q000201:enzymology*; D007202:Indicators and Reagents; D010397:Penicillanic Acid / Q000138:chemical synthesis* / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid