Kinetics of peripheral blood T cell numbers and functions in patients with burns.
Cell-mediated immunity (CMI) was assessed in 58 patients with burns involving 10% to 40% of the total body surface area (TBSA), and in 16 normal healthy individuals, by using two parameters, the total T-cell counts in peripheral circulation and T-cell function as indicated by the leukocyte migration inhibition (LMI) test. Three recall antigens from Candida albicans, S. typhi, and E. histolytica were used to elicit the LMI. T-cell function was found to be significantly depressed in burns involving more than 25% TBSA. Depression of T-cell function started after the seventh postburn (PB) day and continued until the sixtieth PB day.
D000941:Antigens / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D000946:Antigens, Fungal / Q000276:immunology; D001830:Body Surface Area; D002056:Burns / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology; D002464:Cell Migration Inhibition; D004748:Entamoeba histolytica / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007700:Kinetics; D007958:Leukocyte Count; D012485:Salmonella typhi / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000941:Antigens; D000942:Antigens, Bacterial; D000946:Antigens, Fungal