Cell-mediated immune response to Ross River virus in mice: evidence for a defective effector cell response.
Spleen cells recovered from mice during a primary infection with Ross River virus showed a virus-specific proliferative response when challenged in vitro. The majority of the proliferating cells were T-lymphocytes. In contrast, there was little detectable migration inhibition factor production by these spleen cells and little or no virus-specific cytotoxic activity. Sub-cutaneous challenge with virus elicited a weak delayed type hypersensitivity reaction.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D005260:Female; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000276:immunology; D007518:Isoantibodies / Q000276:immunology; D008222:Lymphokines / Q000032:analysis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012398:Ross River virus; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D014036:Togaviridae Infections / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D007518:Isoantibodies; D008222:Lymphokines; C035678:anti-Thy antibody; D003165:Complement System Proteins