Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.
A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.
D000595:Amino Acid Sequence; D000818:Animals; D002471:Cell Transformation, Neoplastic; D005796:Genes; D005814:Genes, Viral; D006133:Growth Substances / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D009693:Nucleic Acid Hybridization; D020575:Oncogene Proteins v-sis; D009857:Oncogenes; D010455:Peptides / Q000235:genetics* / Q000302:isolation & purification; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger / Q000235:genetics; D012190:Retroviridae / Q000235:genetics*; D012842:Sarcoma Virus, Woolly Monkey / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
D006133:Growth Substances; D046911:Macromolecular Substances; D020575:Oncogene Proteins v-sis; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; D014764:Viral Proteins