Influence of adrenocorticotropic hormone on the growth of isolated neurons in culture.
The present study reports the influence of adrenocorticotropic hormone (ACTH) on the development of cultured neurons from chick embryo cerebral hemispheres. Cultures were initiated in serum-supplemented medium and then transferred to serum-free hormonally-defined medium containing various concentrations of ACTH1--24. The effects of ACTH on the light microscopic features, metabolic activity and permeation properties were examined. The results demonstrate that ACTH exerts a trophic action on the neurons.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects; D002642:Chick Embryo; D003366:Cosyntropin / Q000494:pharmacology*; D046508:Culture Techniques; D009474:Neurons / Q000166:cytology / Q000187:drug effects
D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone