[Beta-adrenergic influences on the firing of raphe dorsalis neurons after neonatal noradrenergic deafferentation in the rat].
In Rat, neonatal lesion of the locus coeruleus induces modifications of beta-adrenergic regulations at the level of raphe dorsalis neurons. In normal conditions, the firing of serotoninergic raphe cells is not beta-adrenergic dependent. On the contrary in the lesioned animal, iontophoresis of a beta-blocking agent (DL-propranolol) produces a marked inhibition of the serotoninergic unit firing. Various mechanisms may account for this pharmacological response in the lesioned group: a classical hypersensitivity phenomenon, or the persistence of an immature regulation.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D004594:Electrophysiology; D005260:Female; D008125:Locus Coeruleus / Q000502:physiology; D008297:Male; D009474:Neurons / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D011943:Receptors, Adrenergic, beta; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D011433:Propranolol; D009638:Norepinephrine
Influences beta-adrénergiques sur la décharge du noyau raphe dorsalis après déafférentation noradrénergique néonatale chez le rat.