title: Non-B hepatocellular carcinoma: influence of age, sex, alcohol, family clustering, blood transfusion and chronic liver disease.
abstract: In 144 cases of hepatocellular carcinoma (HCC), 166 cases of cirrhosis without HCC and 142 cases of chronic hepatitis, we examined HBsAg, anti-HBs and anti-HBc in sera and compared the following factors between hepatitis B virus marker-negative and -positive patients: age, sex, alcohol consumption, family clustering of liver diseases, and histories of blood transfusion and post-transfusion hepatitis. Results of this study demonstrated several distinct differences in clinical backgrounds between non-B (negative for HBsAg, anti-HBs and anti-HBc) and B (positive for HBsAg) patients with HCC. Non-B patients were significantly older, had a lower frequency of familial tendencies for liver diseases, and more frequently had cancers other than HCC in their families. Some of these differences were also observed between non-B and B patients with cirrhosis and chronic hepatitis. Among patients with chronic hepatitis, the non-B patients had received blood transfusion or had post-transfusion hepatitis more frequently than the B patients. However, this difference was not apparent in patients with liver cirrhosis or HCC, suggesting that progression of non-A, non-B post-transfusion hepatitis to cirrhosis and HCC may not be as frequent as progression to chronic hepatitis.
mesh_terms: D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking; D001803:Blood Transfusion; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000276:immunology*; D005260:Female; D006505:Hepatitis / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000150:complications*; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000276:immunology; D008107:Liver Diseases / Q000235:genetics; D008113:Liver Neoplasms / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D006510:Hepatitis B Antibodies