Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.
The ability of fibronectin to bind cells can be accounted for by the tetrapeptide L-arginyl-glycyl-L-aspartyl-L-serine, a sequence which is part of the cell attachment domain of fibronectin and present in at least five other proteins. This tetrapeptide may constitute a cellular recognition determinant common to several proteins.
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D005353:Fibronectins / Q000378:metabolism*; D007668:Kidney; D007700:Kinetics; D009842:Oligopeptides / Q000378:metabolism* / Q000494:pharmacology; D011487:Protein Conformation; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D017469:Receptors, Fibronectin
D005353:Fibronectins; D009842:Oligopeptides; D011956:Receptors, Cell Surface; D017469:Receptors, Fibronectin