title: [Activity of sulbactam and clavulanic acid, alone and combined, on Acinetobacter calcoaceticus].
abstract: Sulbactam and clavulanic acid, both beta-lactamase inhibitors, were studied alone or associated on 85 isolates of Acinetobacter calcoaceticus. When sulbactam was tested alone the minimal inhibitory concentration (MIC) was less than 2 micrograms/ml with the carbenicillin-sensitive strains of A. Calcoaceticus and between 8 to 16 micrograms/ml with the carbenicillin-resistant strains. In the presence of clavulanic acid (5 or 10 micrograms/ml) the MIC of sulbactam on all the carbenicillin-resistant strains decreased to less than 4 micrograms/ml.
mesh_terms: D000150:Acinetobacter / Q000187:drug effects*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000494:pharmacology*; D013407:Sulbactam
chemical_list: D002969:Clavulanic Acids; D019818:Clavulanic Acid; D010397:Penicillanic Acid; D013407:Sulbactam
vernacular_title: Activité du sulbactam et de l'acide clavulanique, seuls et associés, sur Acinetobacter calcoaceticus.