The effect of gyrase inhibitors and cyclic AMP on induction and glucose repression of the 6-hydroxy-nicotine oxidases in Arthrobacter oxidans.
The induction by D,L-nicotine of the enantiozymes 6-hydroxy-L-nicotine oxidase and 6-hydroxy-D-nicotine oxidase in Arthrobacter oxidans was differently affected by the inhibitors of Escherichia coli gyrase, novobiocin and nalidixic acid. These compounds inhibited 6-hydroxy-L-nicotine oxidase induction slightly, but led to an increase in the level of 6-hydroxy-D-nicotine oxidase activity. Furthermore, the specific repression by glucose of 6-hydroxy-D-nicotine oxidase synthesis was not abolished by the addition of cAMP but by that of novobiocin.
D001173:Arthrobacter / Q000201:enzymology*; D000242:Cyclic AMP / Q000494:pharmacology*; D004790:Enzyme Induction; D004794:Enzyme Repression / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology*; D009268:Nalidixic Acid / Q000494:pharmacology; D009675:Novobiocin / Q000494:pharmacology; D010088:Oxidoreductases / Q000096:biosynthesis*; D059005:Topoisomerase II Inhibitors
D059005:Topoisomerase II Inhibitors; D009675:Novobiocin; D009268:Nalidixic Acid; D000242:Cyclic AMP; D010088:Oxidoreductases; C021413:6-hydroxy-D-nicotine oxidase; D005947:Glucose