Pathogen-host jujitsu: phagocyte impotence caused by internalized bacterial adenylate cyclase.
Humans and animals infected with Bordetella species show evidence of impaired host defenses. These pathogenic bacteria produce a unique adenylate cyclase which enters human phagocytes and catalyzes the unregulated formation of cAMP, a known cellular inhibitor. This unique pathogen-host interaction may explain the unusual features of human B. pertussis infection and represents a powerful new probe for the investigation of cAMP-governed processes.
D000262:Adenylyl Cyclases / Q000032:analysis / Q000378:metabolism*; D001886:Bordetella pertussis / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000378:metabolism; D010586:Phagocytes / Q000378:metabolism / Q000502:physiology*
D000242:Cyclic AMP; D000262:Adenylyl Cyclases