title: The presence of phospholipase D in rat central nervous system axolemma.
abstract: An axolemma-enriched fraction prepared from a purified myelinated axon fraction isolated from rat CNS was found to contain phospholipase D at a specific activity similar to that of a microsomal fraction isolated from whole brain. There was a concomitant threefold enrichment in the specific activity of phospholipase D and acetylcholinesterase in the axolemma-enriched fraction compared with the specific activities of these enzymes in the starting white matter whole homogenate. This axonal phospholipase D may be involved in remodeling of phospholipid, which in turn may affect axonal functions such as ion translocation.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000201:enzymology* / Q000648:ultrastructure; D001921:Brain / Q000201:enzymology*; D002458:Cell Fractionation; D002462:Cell Membrane / Q000201:enzymology; D003576:Electron Transport Complex IV / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000378:metabolism; D010739:Phospholipase D / Q000378:metabolism*; D010740:Phospholipases / Q000378:metabolism*; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology
chemical_list: D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; D010740:Phospholipases; D000110:Acetylcholinesterase; D010739:Phospholipase D