Identifying superoxide-sensitive progenitor cells in mouse bone marrow.
Macrophage progenitor cells in bone marrow, that develop into attached colonies in liquid culture medium, contain a fraction of cells sensitive to photochemically generated superoxide radicals. This fraction varies from one animal to another. Populations of cells containing the superoxide-sensitive fraction show a greater sensitivity to X-rays than do populations in which this fraction has been photochemically inactivated. The change in radiosensitivity was proportional to the superoxide-sensitive fraction.
D000818:Animals; D001854:Bone Marrow Cells; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008027:Light; D051379:Mice; D011836:Radiation Tolerance; D013234:Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D013481:Superoxides / Q000494:pharmacology*
D013481:Superoxides