(+)-Tubocurarine blocks the Ca2+-dependent K+-channel of the bullfrog sympathetic ganglion cell.
(+)-Tubocurarine [+)-Tc: 10-100 microM) reduced the duration of the afterhyperpolarization, which was induced by the activation of Ca2+-dependent K+-conductance (GK,Ca) following an action potential in the bullfrog sympathetic ganglion cell, but did not affect the maximum rates of rise and fall of Na+- and Ca2+-dependent action potentials. The amplitudes of slow rhythmic membrane hyperpolarizations produced by rhythmic rises in the GK,Ca were also decreased by (+)-Tc without a change in their intervals. Thus, (+)-Tc appears to block the Ca2+-dependent K+-channel of the bullfrog sympathetic ganglion cell.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D011892:Rana catesbeiana; D011978:Receptors, Nicotinic / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology*
D007473:Ion Channels; D011978:Receptors, Nicotinic; D011188:Potassium; D002118:Calcium; D014403:Tubocurarine