Unscheduled DNA synthesis induced by nitrosated ranitidine in primary cultures of rat hepatocytes.
In vitro, the reaction, in acidified solution, of the histamine H2 receptor antagonist ranitidine with excess nitrite, yielded nitroso derivative(s) eliciting a dose-dependent amount of unscheduled DNA synthesis in primary cultures of rat hepatocytes.
D000818:Animals; D002478:Cells, Cultured; D004260:DNA Repair; D004261:DNA Replication / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009152:Mutagenicity Tests; D009153:Mutagens; D009573:Nitrites; D009603:Nitroso Compounds / Q000633:toxicity*; D011899:Ranitidine; D051381:Rats; D012977:Sodium Nitrite
D009153:Mutagens; D009573:Nitrites; D009603:Nitroso Compounds; D011899:Ranitidine; D012977:Sodium Nitrite