Pituitary hormones and contact sensitivity in rats.
Hypophysectomized (Hypo-X) rats do not develop contact sensitivity to dinitrochlorobenzene (DNCB). Daily treatment with prolactin or growth hormone completely restores the DNCB-reactivity of Hypo-X animals. Treatment of such animals with ACTH, FSH, LH, TSH or HCG has no restoring potential. Treatment with ACTH in addition to prolactin or growth hormone antagonizes restoration of Hypo-X rats. These experiments indicate that the pituitary gland has the potential of regulating contact sensitivity.
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology; D004137:Dinitrochlorobenzene / Q000008:administration & dosage; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage; D007016:Hypophysectomy; D010908:Pituitary Hormones, Anterior / Q000008:administration & dosage*; D011388:Prolactin / Q000008:administration & dosage; D051381:Rats; D011916:Rats, Inbred F344; D011920:Rats, Inbred WF
D004137:Dinitrochlorobenzene; D010908:Pituitary Hormones, Anterior; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone