The effect of vanadate on aqueous humor dynamics in cynomolgus monkeys.
Topical administration of 1% vanadate in a formulation designed to enhance penetration lowered intraocular pressure in monkeys' eyes. The decrease in intraocular pressure was associated with significant decreases in aqueous humor flow. Tonographic outflow facility was unaltered by topical vanadate.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D007429:Intraocular Pressure / Q000187:drug effects*; D008252:Macaca fascicularis; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D014065:Tonometry, Ocular; D014638:Vanadates; D014639:Vanadium / Q000008:administration & dosage / Q000494:pharmacology*
D014639:Vanadium; D014638:Vanadates; D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase