Ammonia intoxication and hyperpolarizing postsynaptic inhibition.
Systemic ammonia intoxication abolished the hyperpolarizing action of postsynaptic inhibition in the CNS at tissue concentrations of NH+4 which are sufficient to produce the earliest signs of encephalopathy. Therefore, the action of NH+4 on hyperpolarizing postsynaptic inhibition has to be considered as the cause, or as a contributing cause, of the encephalopathy due to systemic ammonia intoxication.
D000641:Ammonia / Q000494:pharmacology*; D000818:Animals; D001927:Brain Diseases / Q000378:metabolism; D002415:Cats; D009433:Neural Inhibition / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D000641:Ammonia