Identification of an amiloride sensitive Na+/H+ exchange system in brain synaptosomes.
This paper reports the presence of a Na+-uptake component in rat brain synaptosomes that is coupled to H+-efflux as monitored from the acidification of the extrasynaptosomal space. This exchange mechanism is inhibited by amiloride and two of its more potent derivatives: dimethylamiloride and ethylisopropylamiloride.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D046508:Culture Techniques; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects*
D007473:Ion Channels; D011719:Pyrazines; D000584:Amiloride; D012964:Sodium