[Effect of the kallikrein-kinin system on gastric mucosa].
I. m.administration of andecalin increased vascular permeability, induced microhemorrhages in the gastric mucosa and intensified secretion of mucopolysaccharides in patients. Bradykinin inhibited secretion of hydrochloric acid in the frog gastric mucosa. Activity of the kallikrein -kinin system was found to be increased in the blood flowing from the stomach as compared with the system activity in peripheral venous blood in dogs. The kallikrein -kinin system seems to participate in regulation of basic gastric functions, particularly in inhibiting the gastric secretion and in regulation of the mucosa defense barrier.
D000328:Adult; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000097:blood / Q000494:pharmacology*; D007704:Kininogens / Q000097:blood; D001121:Lysine Carboxypeptidase / Q000097:blood; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011893:Rana esculenta; D012039:Regional Blood Flow; D000515:alpha 1-Antitrypsin / Q000032:analysis
D006025:Glycosaminoglycans; D007704:Kininogens; D000515:alpha 1-Antitrypsin; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase; D007610:Kallikreins; D001920:Bradykinin
Vliianie kallikrein-kininovoĭ sistemy na slizistuiu obolochku zheludka.