Growth-dependent expression of a cell surface glycoprotein.
The expression of the hepatocellular membrane receptor for desialylated galactose-termining glycoproteins was studied during different proliferative stages of a human hepatoma cell line. Rapidly growing cells exhibited a reduced endocytotic rate of desialylated orsomucoid as compared to non-growing cells. This reduction was shown to be the consequence of a lower concentration of active cell-surface associated receptor protein in the dividing cells.
D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002352:Carrier Proteins / Q000302:isolation & purification; D002455:Cell Division; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D006023:Glycoproteins / Q000302:isolation & purification*; D006801:Humans; D008113:Liver Neoplasms; D009363:Neoplasm Proteins / Q000302:isolation & purification; D013499:Surface Properties
D002352:Carrier Proteins; D006023:Glycoproteins; D009363:Neoplasm Proteins