Attempted reactivation of latent bovine herpesvirus 1 infection in calves by infection with ruminant pestiviruses.
Three calves, latently infected with bovine herpesvirus 1 (BHV 1), were each inoculated intranasally with 9 strains of ruminant pestivirus (BVDV). All three calves developed a biphasic pyrexia and a lymphopenia followed by a neutrophilia. They did not shed BHV 1 in their nasal secretions in the 14 days following BVDV inoculation, and their BHV 1 antibody levels remained static, as did those of 2 control calves not given BVDV. All five calves were subsequently shown to be latently infected with BHV 1 by the production of recrudescent infections following the administration of dexamethasone. BHV 1 was recovered from nasal secretions and there was a marked rise in BHV 1 antibody titres in the second week after dexamethasone administration.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology* / Q000382:microbiology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000382:microbiology; D003907:Dexamethasone / Q000494:pharmacology; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology*; D006564:Herpesviridae / Q000254:growth & development* / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology; D010576:Pestivirus / Q000276:immunology*; D014775:Virus Activation / Q000187:drug effects
D000914:Antibodies, Viral; D003907:Dexamethasone