Effects of monoclonal antibodies directed against herpes simplex virus-specified glycoproteins on the generation of virus-specific and H-2-restricted cytotoxic T-lymphocytes.
Passive transfer of monoclonal antibodies specific for herpes simplex virus type 1 (HSV-1) glycoproteins gC or gD resulted in the generation of highly potent HSV-specific and H-2-restricted primary cytotoxic T-lymphocytes (CTL) in the lymph nodes of recipients provided they were injected at 12 h post-infection. When the same antibody was injected at 3 h before HSV infection, the recipients failed to generate primary anti-HSV CTL. Rather, lymph node cells from such donors proved unsuitable for the initiation in vitro of a secondary anti-HSV CTL response by restimulation.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006183:H-2 Antigens / Q000276:immunology*; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018139:Simplexvirus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013997:Time Factors; D014764:Viral Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006023:Glycoproteins; D006183:H-2 Antigens; D014764:Viral Proteins