Autoradiographic localization of beta-adrenoceptors in rat kidney.
The beta-adrenoceptor antagonist radioligand [125I]cyanopindolol (CYP) has been used to localize beta-adrenoceptors in rat kidney sections. [125I]CYP bound with high affinity to sites in rat kidney sections having the recognition characteristics of beta-adrenoceptors. Autoradiographic studies combined with histochemical techniques demonstrated that the beta-adrenoceptors were primarily located on renal glomeruli, distal and cortical collecting tubules rather than on proximal tubules or vascular elements.
D000818:Animals; D001345:Autoradiography; D020120:Iodocyanopindolol; D007668:Kidney / Q000032:analysis*; D008297:Male; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D011943:Receptors, Adrenergic, beta; D020120:Iodocyanopindolol; D010869:Pindolol