Hyperimmune immunoglobulin therapy for cytomegalovirus infections in renal transplant patients.
Eleven renal transplant patients with CMV infection have been treated by passive immunisation, one with high-titre anti-CMV plasma and 10 with fractionated hyperimmune anti-CMV immunoglobulin. All were pyrexial for at least seven days before treatment with typical clinical and laboratory features of CMV infection. Seven of the 11 patients treated showed a striking and sustained response within 24-48 hours of therapy, with lysis of fever, resolution of pneumonitis, a rise in white cell count and improvement in renal function and liver function tests.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000008:administration & dosage*; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000628:therapy*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D000914:Antibodies, Viral; D007136:Immunoglobulins