title: Bisphosphoglycerate synthase activity in cells of the erythrocytic line of rat.
abstract: The specific activity of bisphosphoglycerate synthase (EC 2.7.5.4) is significantly higher in rat mature erythrocytes than in reticulocytes from phenylhydrazine treated animals, while 2,3-bisphosphoglycerate levels do not differ between them. The enzyme specific activity and the concentration of 2,3-bisphosphoglycerate are both negligible in the erythroid cell pool from the bone marrow of anaemic animals. Thus, a cellular specialization in the last stages of erythropoiesis is confirmed. Human bisphosphoglycerate synthase shows a lower specific activity than that of rat without a parallel decrease in 2,3-bisphosphoglycerate levels.
mesh_terms: D019794:2,3-Diphosphoglycerate; D000740:Anemia / Q000097:blood / Q000201:enzymology; D000818:Animals; D001731:Bisphosphoglycerate Mutase / Q000097:blood*; D001853:Bone Marrow / Q000201:enzymology; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology*; D004920:Erythropoiesis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D010659:Phenylhydrazines; D010770:Phosphotransferases / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000201:enzymology*
chemical_list: D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010659:Phenylhydrazines; D019794:2,3-Diphosphoglycerate; D010770:Phosphotransferases; D001731:Bisphosphoglycerate Mutase