title: Platelet abnormalities in muscular dystrophy.
abstract: Platelets which have complex membranes and calcium shifts similar to those in muscles were investigated in 14 patients with muscular dystrophy and 20 suitable controls. In 4 Duchenne and one limb-girdle dystrophy aggregations were done and found to be depressed with adrenaline and ADP. Electron microscopic and chemical examinations revealed an increased number of dense bodies, changed permeability and/or binding of cations and elevated intracellular calcium in all the 9 cases of Duchenne dystrophy while the 2 limb-girdle and 3 myotonic dystrophies varied. A two phase polymer separation system applied to fixed platelets of all patients and controls showed no abnormality of surface negative charge.
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000145:classification / Q000378:metabolism / Q000648:ultrastructure*; D002118:Calcium / Q000097:blood; D002463:Cell Membrane Permeability; D002469:Cell Separation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood*; D010974:Platelet Aggregation; D010976:Platelet Count
chemical_list: D002118:Calcium