title: Unsuccessful DTIC treatment of a patient with glucagonoma syndrome.
abstract: Various chemotherapeutic modalities have been tried in the treatment of patients with malignant glucagonomas. Promising results have been reported after drug treatment with dimethyltriazenoimidazole carboxamide (DTIC). We present a patient with a metastasizing pancreatic glucagonoma, in whom treatment with neither DTIC nor with the combination of streptozotocin and 5-fluorouracil resulted in any noticeable improvement.
mesh_terms: D007516:Adenoma, Islet Cell / Q000188:drug therapy*; D003606:Dacarbazine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use; D005935:Glucagonoma / Q000188:drug therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D013311:Streptozocin / Q000627:therapeutic use
chemical_list: D013311:Streptozocin; D003606:Dacarbazine; D005472:Fluorouracil