Lack of association between [3H]imipramine binding sites and uptake of serotonin in control, depressed and schizophrenic patients.
Uptake of serotonin and [3H]imipramine binding were studied in parallel in the platelets of control, depressed and schizophrenic patients. In the depressed patient group, uptake of serotonin was consistently reduced while [3H]imipramine binding was only decreased in a number of these patients. In the schizophrenic group, uptake of serotonin was reduced to 62% of control with no changes in [3H]imipramine binding being observed. These data demonstrate a clear dissociation between uptake of serotonin and [3H]imipramine binding sites in human platelets. The possible functional role of these [3H]imipramine binding sites remains to be determined.
D001792:Blood Platelets / Q000378:metabolism; D002352:Carrier Proteins; D003866:Depressive Disorder / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012559:Schizophrenia / Q000097:blood / Q000378:metabolism*; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D012701:Serotonin; D007099:Imipramine