[Usefulness of the determination of nephrogenous cyclic AMP in the diagnosis of primary hyperparathyroidism].
The analysis of nephrogenous cyclic AMP (NcAMP) has been reported to be a means of estimating parathyroid function with the advantage of being rapidly and easily performed. More specific than the analysis of urinary cyclic AMP (UcAMP), it measures biological activity of the parathyroid hormone. This study tests its use in the diagnosis of primary hyperparathyroidism (HPP) and compares the results of UcAMP with those of NcAMP. Analyses of NcAMP and parathyroid hormone were performed in a group of 21 healthy controls and two groups of hypercalcemic patients, one consisting of 12 patients with HPP and the other of 14 patients with hypercalcemia of non-parathyroid origin (HCa). It was confirmed that NcAMP is a parameter of parathyroid function, analysis of which allows the diagnosis of HPP with the same precision as analysis of the carboxyterminal plasma PTH. It has the added advantage over PTH measurements of detecting low values, thus permitting documentation of parathyroid inhibition in HCa patients.
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D000242:Cyclic AMP / Q000032:analysis* / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000175:diagnosis; D007668:Kidney / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000032:analysis; D011863:Radioimmunoassay
D010281:Parathyroid Hormone; D000242:Cyclic AMP; D002118:Calcium
Utilité du dosage de l'AMP cyclique néphrogène dans le diagnostic de l'hyperparathyroïdie primaire.