The sites of action of cholecystokinin in decreasing meal size in pigs.
The synthetic octapeptide of cholecystokinin (CCK-8) was infused at the rate of 67 ng/kg-minute into the jugular vein, carotid artery, portal vein, gastric branch of the splenic artery, and aortic artery both craniad and caudad to the origins of the cranial mesenteric and coeliac arteries of 39 young female pigs. Jugular, carotid and cranial erotic infusions resulted in significant reduction of meal size respectively to 65, 67 and 71% of control meal size (p less than 0.05). Gastric artery infusion resulted in a significant increase of meal size to 122% of control meal size (p less than 0.05). Portal vein and caudal aortic artery infusions had no significant effects on meal size. The results were interpreted as indicating a major site of action of CCK in reducing meal size in the bed of the cranial mesenteric or coeliac arteries, but excluding the stomach and liver.
D000818:Animals; D004386:Duodenum / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D005260:Female; D007082:Ileum / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000187:drug effects; D011949:Receptors, Cholecystokinin; D012527:Satiation / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology*; D013552:Swine
D011956:Receptors, Cell Surface; D011949:Receptors, Cholecystokinin; D012844:Sincalide