Myelination in rabbit optic nerves is accelerated by artificial eye opening.
Artificial opening of the eyes of young rabbits on the 5th postnatal day led to accelerated myelination: the myelin-specific basic and proteolipid proteins nearly doubled between the 7th and the 10th postnatal days when compared to controls; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) activity also increased by about 60%. Conversely, lowered AChE activities presumably reflected elevated myelin/axolemma ratios. Myelination in treated animals normalized during later ontogenetic stages (greater than 20th postnatal day).
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D002452:Cell Count; D008027:Light; D009185:Myelin Proteins / Q000032:analysis; D009186:Myelin Sheath / Q000502:physiology*; D009413:Nerve Fibers, Myelinated; D009900:Optic Nerve / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D051381:Rats
D009185:Myelin Proteins; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases