Induced changes in the affinity of 1,25-dihydroxyvitamin D3 receptors in chick intestine.
The contents of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in plasma and intestinal mucose were increased by dietary calcium and by dietary phosphorus restriction. The concentration of intestinal occupied receptors for 1,25(OH)2D3 was higher in calcium-restricted birds. The affinity (association constant) of intestinal receptors for 1,25(OH)2D3 was lower in phosphorus-restricted chicks, as compared to control or calcium-restricted chicks. The number of binding sites were not influenced by dietary calcium or phosphorus restriction.
D000818:Animals; D002118:Calcium / Q000097:blood / Q000172:deficiency*; D002645:Chickens; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D010710:Phosphates / Q000097:blood; D010758:Phosphorus / Q000172:deficiency*; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000378:metabolism*
D010710:Phosphates; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D010758:Phosphorus; D002118:Calcium