S-100 antigen labels neoplastic cells in liposarcoma and cartilaginous tumours.
S-100 antigen, originally believed to be unique to the nervous system, has recently been found in cell types of non-neuroectodermal origin such as chondrocytes and adipocytes. These findings suggested the possibility of detecting the antigen in tumours derived from such cells. Using the PAP method and an anti-ox brain S-100, the antigen was found in the cells of human chondrosarcomas, chondroblastomas and liposarcomas. In contrast, fibrous histiocytomas and fibrosarcomas, tested to verify the cellular specificity of the S-100 immunoreaction, did not exhibit S-100-containing cell types. The present data indicate the usefulness of the S-100 antigen as a diagnostic and investigative tool in defined neoplasms of non-neuroectodermal origin, such as chondroid tumours and liposarcoma.
D001706:Biopsy; D002804:Chondroblastoma / Q000032:analysis*; D002813:Chondrosarcoma / Q000032:analysis*; D005354:Fibrosarcoma / Q000032:analysis; D018219:Histiocytoma, Benign Fibrous / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008080:Liposarcoma / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis*
D009418:S100 Proteins