Prenatal ACTH and corticosterone: effects on reproduction in male mice.
Injections of ACTH or corticosterone into late pregnant mice from Days 14 to 21 did not alter testes weights or feminine copulatory behavior of male offspring in adulthood. However masculine copulatory behavior was significantly reduced. Because ACTH does not cross the placenta, alterations in sexual behavior of male offspring were probably mediated by maternal corticosteroid secretion.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice / Q000502:physiology*; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012098:Reproduction / Q000187:drug effects*; D013737:Testis / Q000254:growth & development
D000324:Adrenocorticotropic Hormone; D003345:Corticosterone