[Carcinogenic activity of ethylene oxide and its reaction products 2-chlorethanol, 2-bromoethanol, ethylene glycol and diethylene glycol. II. Testing of 2-chlorethanol and 2-bromoethanol for carcinogenic activity].
The compounds 2-chloroethanol and 2-bromoethanol were administered once weekly subcutaneously to groups of 100 female NMRI mice, in the case of 2-chloroethanol in 3 dosages (3.0, 1.0 and 0.3 mg, single dosage per mouse) and 2-bromoethanol in 2 dosages (1.0 and 0.3 mg, single dosage per mouse). Tricaprylin was used as solvent. The mean total dosage per mouse was 175.9,76.3 and 23.0 for 2-chloroethanol and 72.7 and 21.0 mg for 2-bromoethanol. In addition, by intragastric treatment of rats with two dosages (single dosage 10.0 and 2.5 mg/kg body weight), 2-chloroethanol was examined for carcinogenicity. The solvent used here was salad-oil. The mean total dosage per rat amounted to 1706 or, respectively, to 434 mg/kg of body weight. No carcinogenic effect could be determined in the case of either of the test substances, 2-chloroethanol and 2-bromoethanol.
D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes; D002210:Caprylates / Q000008:administration & dosage; D002470:Cell Survival / Q000187:drug effects; D002728:Chlorohydrins / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D005023:Ethylene Chlorohydrin / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007279:Injections, Subcutaneous; D007441:Intubation, Gastrointestinal; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009821:Oils / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D012997:Solvents; D014280:Triglycerides / Q000008:administration & dosage
D001580:Benzopyrenes; D002210:Caprylates; D002728:Chlorohydrins; D009821:Oils; D012997:Solvents; D014280:Triglycerides; D001564:Benzo(a)pyrene; D000431:Ethanol; C003637:tricaprylin; D005023:Ethylene Chlorohydrin; C025475:ethylene bromohydrin
Kanzerogene Aktivität von Ethylenoxid und seinen Reaktions-produkten 2-Chlorethanol, 2-Bromethanol, Ethylenglycol und Diethylenglycol. II. Untersuchung von 2-Chlorethanol und 2-Bromethanol auf kanzerogene Wirkung.