title: A comparison of the virulence of three strains of infectious bovine rhinotracheitis virus.
abstract: The virulence of three strains of infectious bovine rhinotracheitis (IBR) virus was compared in six-month-old Ayrshire-cross calves. The strains were an isolate from a recent severe outbreak of IBR in Scotland (Strichen strain), the prototype British strain (Oxford strain) and a North American isolate (Colorado strain). The Colorado and Strichen strains produced the characteristic clinical signs and pathological lesions of severe IBR three to four days post infection (p.i.). The Strichen strain was slightly more virulent, possibly as a result of its having been passaged fewer times in tissue culture. In contrast, the Oxford strain produced a mild clinical response with minimal pathological lesions. Virus was recovered from nasal swabs for a longer-period from the calves infected with the Strichen strain (up to 13 days p.i.) and Colorado strain (up to 12 days p.i.) than from the animals infected with the Oxford strain (up to 10 days p.i.). These findings support the suggestion that the recent epidemic of severe IBR in Britain had resulted from the importation of a "new" strain of virus.
mesh_terms: D000818:Animals; D002417:Cattle; D007242:Herpesvirus 1, Bovine / Q000302:isolation & purification / Q000472:pathogenicity*; D007241:Infectious Bovine Rhinotracheitis / Q000382:microbiology* / Q000473:pathology; D007830:Larynx / Q000473:pathology; D008168:Lung / Q000473:pathology; D009666:Nose / Q000382:microbiology; D010614:Pharynx / Q000473:pathology; D014132:Trachea / Q000473:pathology; D014774:Virulence