title: Steroid-membrane-adenylate cyclase interactions during Xenopus laevis oocyte meiosis reinitiation: a new mechanism of steroid hormone action.
abstract: Progesterone acts physiologically on Xenopus laevis oocyte meiosis reinitiation in interacting with plasma membrane. Hormonal studies indicate a specific "receptor-like" structure. The involvement of membrane adenylate cyclase activity which is selectively decreased by progesterone is described in intact oocytes as well as in a cell-free membrane containing system. The participation of Ca2+ changes and of phospholipid components of membrane is analyzed. We discuss the possibility that the progesterone-oocyte system is a model for understanding other steroid hormone activities in other target cells.
mesh_terms: D000262:Adenylyl Cyclases / Q000032:analysis*; D000818:Animals; D002118:Calcium / Q000502:physiology; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D000242:Cyclic AMP / Q000032:analysis; D005260:Female; D007328:Insulin / Q000494:pharmacology; D008540:Meiosis / Q000187:drug effects*; D009865:Oocytes / Q000166:cytology / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology*; D014982:Xenopus laevis
chemical_list: D007328:Insulin; D010455:Peptides; D011374:Progesterone; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D002118:Calcium