title: Agonist effects on the intracellular cyclic AMP concentration of retinal pigment epithelial cells in culture.
abstract: Accumulation of cyclic AMP in intact cultured pigment epithelial cells was rapidly enhanced by several agonists. These included vasoactive intestinal peptide (100-fold), glucagon (fivefold), thyroid-stimulating hormone (threefold), prostaglandin E1 (24-fold), L-isoproterenol (27-fold), and histamine (fourfold). The rapidity and magnitude of these effects suggest that these agonists may regulate important retinal pigment epithelial cell functions.
mesh_terms: D000527:Alprostadil; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D000242:Cyclic AMP / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D010857:Pigment Epithelium of Eye / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology; D013972:Thyrotropin / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
chemical_list: D011458:Prostaglandins E; D014660:Vasoactive Intestinal Peptide; D006632:Histamine; D013972:Thyrotropin; D005934:Glucagon; D000242:Cyclic AMP; D000527:Alprostadil; D007545:Isoproterenol