Effects of sodium-valproate administration on plasma ACTH levels in patients with ACTH hypersecretion.
The effects of the acute administration of sodium-valproate (400 mg po) on plasma ACTH levels were studied in 4 patients with Cushing's disease, 1 with Nelson's syndrome and in 3 with Addison's disease. No significant reduction of corticotropin concentration was observed, as compared to saline infusion. These data do not favor the hypothesis of an inhibitory role of sodium-valproate on ACTH secretion in such patients.
D000224:Addison Disease / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000378:metabolism; D003480:Cushing Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D009347:Nelson Syndrome / Q000097:blood*; D010911:Pituitary Neoplasms / Q000097:blood*; D014635:Valproic Acid / Q000494:pharmacology*
D014635:Valproic Acid; D000324:Adrenocorticotropic Hormone