title: Placental transfer of cefotiam dihydrochloride.
abstract: The concentrations of cefotiam dihydrochloride (CTM) in maternal and fetal blood and in amniotic fluid were determined by bioassay in 38 women at parturition. With an intravenous infusion of 1 g of CTM, the decline in concentration of CTM in maternal blood was biphasic; CTM  was not detectable at 6 h after administration. Peak levels of CTM in umbilical cord blood (13.0 to 23.9 micrograms/ml) were attained between 15 and 28 min after intravenous infusion; those in amniotic fluid (19.6 to 23.5 micrograms/ml) were attained at ca. 2.5 h.
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D015310:Cefotiam; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D015310:Cefotiam; D002439:Cefotaxime