Agonist effects on the intracellular cyclic AMP concentration of retinal pigment epithelial cells in culture.
Accumulation of cyclic AMP in intact cultured pigment epithelial cells was rapidly enhanced by several agonists. These included vasoactive intestinal peptide (100-fold), glucagon (fivefold), thyroid-stimulating hormone (threefold), prostaglandin E1 (24-fold), L-isoproterenol (27-fold), and histamine (fourfold). The rapidity and magnitude of these effects suggest that these agonists may regulate important retinal pigment epithelial cell functions.
D000527:Alprostadil; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D000242:Cyclic AMP / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D010857:Pigment Epithelium of Eye / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology; D013972:Thyrotropin / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D011458:Prostaglandins E; D014660:Vasoactive Intestinal Peptide; D006632:Histamine; D013972:Thyrotropin; D005934:Glucagon; D000242:Cyclic AMP; D000527:Alprostadil; D007545:Isoproterenol