title: Ibuprofen inhibits granulocyte responses to inflammatory mediators. A proposed mechanism for reduction of experimental myocardial infarct size.
abstract: The use of nonsteroidal antiinflammatory agents to reduce myocardial infarct size has demonstrated a dichotomy between ibuprofen, which reduces myocardial infarct size, and aspirin, which does not. A feline model of coronary ischemia using ligation of the anterior descending artery demonstrated that intravenous ibuprofen (2.5-20 mg/kg) given immediately and 2 h after ligation significantly decreased (by about 40%) myocardial infarct size. In contrast, aspirin did not diminish infarct size at any achieved dose; in fact, at some doses it tended to increase infarct size. In vitro studies with purified granulocytes demonstrated a similar dichotomy between ibuprofen and aspirin. Ibuprofen inhibits granulocyte aggregation, superoxide production, lysosomal enzyme release, and granulocyte-mediated endothelial cytotoxicity, while aspirin is without effect on these modalities. We propose that ibuprofen's beneficial effect in experimental myocardial ischemia is related to its ability to inhibit activated granulocytes and thus to diminish myocardial cell death in experimental myocardial infarction.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D002415:Cats; D003182:Complement C5 / Q000494:pharmacology; D003331:Coronary Vessels; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology; D007052:Ibuprofen / Q000627:therapeutic use*; D008026:Ligation; D008297:Male; D009203:Myocardial Infarction / Q000517:prevention & control*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D013481:Superoxides / Q000096:biosynthesis
chemical_list: D003182:Complement C5; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D001241:Aspirin; D007052:Ibuprofen