title: Pattern reversal visual evoked potentials in awake rats.
abstract: A method for recording pattern reversal evoked potentials (PREPs) from awake restrained rats has been developed. The procedure of Onofrj et al. [26] was modified to eliminate the need for anesthetic, thereby avoiding possible interactions of the anesthetic with other manipulations of interest. Rats were restrained in a harness and placed in front of a pattern generating TV screen displaying a black and white alternating square wave grating. Using various stimulation and recording parameters, normative data are presented from 141 adult male Long-Evans hooded and 11 adult male Sprague-Dawley albino rats. Reliable waveforms were recorded with five identifiable peaks. The labels and mean latencies of these peaks in hooded rats were: N1, 47.3 msec; P1, 65.7 msec; N2, 83.3 msec; P2, 94.4 msec; and N3, 129.8 msec. Spatial acuity functions generated with PREPs gave acuity estimates which corresponded closely to values determined behaviorally for hooded and albino rats [4,11].
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005556:Form Perception / Q000502:physiology*; D008297:Male; D009115:Muridae; D010364:Pattern Recognition, Visual / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D014793:Visual Cortex / Q000502:physiology*
chemical_list: D001285:Atropine