IgA antibodies to herpes simplex virus type 1 in duodenal juice and saliva from patients with peptic ulcer and non-ulcer controls.
Fasting duodenal juice and saliva were obtained from 26 peptic ulcer patients and 28 controls. IgA antibodies to herpes simplex virus type 1 (HSV-1) were measured by the indirect enzyme-linked immunosorbent assay (ELISA). Total IgA in the samples was measured by the double-sandwich ELISA. The median and interquartile range of anti HSV-1 IgA titres in saliva were 8 (4-12) and 4 (1-8) in ulcer patients and controls, respectively (p less than 0.02). Comparative values in duodenal juice were 12 (2-16) and 4 (0-6) (p less than 0.002). The concentration of total IgA was not higher in ulcer patients than in controls, and no correlation existed between total IgA and anti HSV-1 titres. The results add further evidence that HSV type 1 is involved in the pathogenesis of peptic ulceration.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D004381:Duodenal Ulcer / Q000276:immunology* / Q000382:microbiology; D004386:Duodenum; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007419:Intestinal Secretions / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000276:immunology*; D018139:Simplexvirus / Q000276:immunology*
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory