Peptide-induced excessive grooming in the rat: the role of opiate receptors.
We have investigated the possibility that opiate peptides induce excessive grooming behavior in the rat via a direct action on an opiate receptor by comparing the opiate agonist dynorphin(1-13) with its non-opioid fragment des-tyrosine1-dynorphin(1-13) (dT-Dyn). We have shown that both peptides are capable of inducing grooming and that this behavior can be suppressed by pretreatment with naloxone. Analysis of the grooming pattern revealed that the response induced by dT-Dyn is qualitatively similar to that induced by ACTH(1-24) and dynorphin(1-13). Cross-tolerance was demonstrated among the various peptides. We conclude that peptide-opiate receptor interaction is not the primary event in the induction of grooming and that the opiate receptor(s) involved are located at another site underlying peptide-induced grooming.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000700:Analgesics / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D003366:Cosyntropin / Q000494:pharmacology*; D004399:Dynorphins; D004723:Endorphins / Q000494:pharmacology*; D006120:Grooming / Q000187:drug effects*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*
D000700:Analgesics; D004723:Endorphins; D010446:Peptide Fragments; D011957:Receptors, Opioid; D003366:Cosyntropin; D009270:Naloxone; C026843:dynorphin (1-13); D004399:Dynorphins; C036730:dynorphin A, desTyr(1)-desTrp(14)-desAsp(15)-desAsn(16)-desGlu(17)-; D000324:Adrenocorticotropic Hormone