Correlated effects of clonidine on single-neuron activities in the gigantocellular reticular nucleus, arterial pressure and heart rate in the cat.
In chloralose-urethane anesthetized cats, intravenous administration of clonidine (10 micrograms/kg) promoted an increase in single-neuron discharges in the gigantocellular reticular nucleus that exhibited a degree and time-course parallel to the hypotension and bradycardia produced by the imidazoline compound. This observation was taken to be a positive indication that clonidine may pharmacologically activate (or disinhibit) neurons in this reticular nucleus, which in turn elicits vasodepression and cardioinhibition.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects*; D002319:Cardiovascular System / Q000294:innervation; D002415:Cats; D003000:Clonidine / Q000494:pharmacology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
D003000:Clonidine