title: Pentylenetetrazol may discriminate between different types of benzodiazepine receptors.
abstract: The effect of various concentrations of pentylenetetrazol (PTZ) on [3H]flunitrazepam binding to benzodiazepine receptors was investigated by Hofstee and Hill plot analyses. These analyses indicate the presence of two PTZ binding sites in forebrain, whereas a single PTZ binding site is present in cerebellum. The relative proportions of the two PTZ binding sites in forebrain are close to those of benzodiazepine Type II and Type I receptors, respectively. These results suggest that PTZ may actually discriminate between different types of benzodiazepine receptors.
mesh_terms: D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011963:Receptors, GABA-A; D014018:Tissue Distribution
chemical_list: D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005445:Flunitrazepam; D010433:Pentylenetetrazole