Histologic and cell surface antigen studies of hematopoietic tumors induced by Cas-Br-M murine leukemia virus.
Cas-Br-M, a cloned ecotropic murine leukemia virus (MuLV) of wild mouse origin that induces both neurogenic hindlimb paralysis and lymphomas, was injected into NFS/N inbred mice neonatally. Then the mice were observed for the development of neurologic disease and tumors. All mice manifested neurologic abnormalities by 6 months of age, and 58% of the animals died with hematopoietic neoplasms. The tumors included T- and B-cell lymphomas, lymphoblastic lymphoma, erythroleukemias, myelogenous leukemias, and a megakaryocytic leukemia. Cas-Br-M thus appeared to be unique among ecotropic MuLV in inducing a wide spectrum of hematopoietic tumors.
D000818:Animals; D000918:Antibody Specificity; D000954:Antigens, Surface / Q000032:analysis*; D005434:Flow Cytometry; D006410:Hematopoiesis; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors
D000954:Antigens, Surface