c-Ha-ras-1 oncogene lies between beta-globin and insulin loci on human chromosome 11p.
DNA sequence polymorphisms have been used to determine the linear order and recombinational distances separating the Harvey ras 1 oncogene (c-Ha-ras-1), beta-globin, insulin, and parathyroid hormone genes on the short arm of human chromosome 11. Our results indicate that c-Ha-ras-1 is closely linked to both the beta-globin locus (theta = .08 [8 centimorgans], lod score = 5.11) and the insulin locus (theta = .04 [4 centimorgans], lod score = 3.31). Furthermore, the probable order of these loci on chromosome 11p is centromere-parathyroid hormone-beta globin-c-Ha-ras-1-insulin.
D000818:Animals; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004247:DNA / Q000235:genetics; D004262:DNA Restriction Enzymes / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D005260:Female; D005814:Genes, Viral; D005914:Globins / Q000235:genetics*; D006251:Harvey murine sarcoma virus / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007328:Insulin / Q000235:genetics*; D008126:Lod Score; D008297:Male; D051379:Mice; D009857:Oncogenes; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D009053:Sarcoma Viruses, Murine / Q000235:genetics*
D004279:DNA, Viral; D007328:Insulin; D005914:Globins; D004247:DNA; D004262:DNA Restriction Enzymes