Does the induction of macrophage lysosomal enzyme secretion by zymosan involve the mannose receptor?
Secretion of the lysosomal enzyme hexosaminidase induced by zymosan is inhibited by mannose and by high concentrations of mannose-6-phosphate and 2-deoxy-glucose but not by mannan. Secretion of hexosaminidase from cells storing previously endocytosed zymosan is unaffected by mannose. Exposure of the cells to mannose does not affect secretion caused by subsequent exposure to zymosan. These findings suggest a role for the mannose-glycoprotein receptor in initiation of lysosomal enzyme secretion by zymosan.
D000818:Animals; D006596:Hexosaminidases / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D037181:Lectins, C-Type; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology*; D008358:Mannose / Q000494:pharmacology; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D051379:Mice; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015054:Zymosan / Q000494:pharmacology*
D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D015054:Zymosan; D007770:L-Lactate Dehydrogenase; D006596:Hexosaminidases; D008358:Mannose