title: [Comparative evaluation of the antibacterial activity of cefotaxime and cephalotin by using an automated antimicrobial susceptibility determination system].
abstract: Cefotaxime is a new broad-spectrum injectable cephalosporin which is stable to most beta-lactamases. In this study we have evaluated the antibacterial activity of cefotaxime comparatively with the activity of cephalotin against 66 Gram-negative bacteria and 31 Gram-positive bacteria by using an automated antimicrobial susceptibility determination system. Cefotaxime was markedly more active than cephalotin against Klebsiella pneumoniae, Proteus, Enterobacter, Escherichia coli and Serratia. Against Gram-positive clinical isolates cefotaxime was less active than cephalotin. Regrowth was observed mainly with cephalotin against Gram-negative clinical isolates, therefore the results obtained after a few hours with automated system should be carefully interpreted.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002439:Cefotaxime / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology*; D003201:Computers; D004353:Drug Evaluation, Preclinical; D008826:Microbial Sensitivity Tests
chemical_list: D002439:Cefotaxime; D002512:Cephalothin
vernacular_title: Valutazione comparativa della attività antibatterica del cefotaxime e della cefalotina mediante un sistema elettronico computerizzato.