title: Effect of some monoamine oxidase inhibitors and cyclic-AMP on plasma fibrinogen level of rats.
abstract: In vivo administration of short acting or long acting inhibitor of monoamine oxidase elevates plasma fibrinogen level in rats. These inhibitors cannot elevate plasma fibrinogen level in rats pretreated with p-chlorophenyl alanine and alpha-methyl-meta-tyrosine, inhibitors of catecholamine and serotonin formation respectively. However, administration of epinephrine or serotonin under the above experimental condition elevates fibrinogen level indicating rise of biogenic monoamine, even for a short period, is a good stimulus for increase of plasma fibrinogen. Dibutyryl cyclic-AMP (c-AMP) also elevates fibrinogen level and shows additive effect with theophylline or serotonin.
mesh_terms: D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D005340:Fibrinogen / Q000032:analysis*; D006246:Harmaline / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000494:pharmacology
chemical_list: D008781:Methyltyrosines; D008996:Monoamine Oxidase Inhibitors; D003994:Bucladesine; D005340:Fibrinogen; C031476:alpha-methyl-m-tyrosine; D013806:Theophylline; D006246:Harmaline; D000242:Cyclic AMP; D010134:Fenclonine