title: Levamisole does not affect the virological and serological responses of bovine leukemia virus-infected cattle and sheep.
abstract: Levamisole, a compound that has been used widely as an anthelmintic in man and domestic animals, has also been found to be an immunomodulator. It was, thus, of interest to determine whether treatment with levamisole would affect bovine leukemia virus infections in cattle and sheep or the results of serological and virological tests routinely used to identify infected animals. Studies of cattle and sheep given either the recommended anthelmintic dose of levamisole or repeated larger doses of the drug failed to provide evidence of significant changes in antibody titer or virus replication. It is, therefore, concluded that levamisole neither potentiated nor repressed bovine leukemia virus replication or the associated immunological responses.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D000914:Antibodies, Viral / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000276:immunology*; D007109:Immunity / Q000187:drug effects; D001909:Leukemia Virus, Bovine / Q000187:drug effects / Q000276:immunology; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000276:immunology*; D007978:Levamisole / Q000494:pharmacology*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000276:immunology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000871:Anthelmintics; D000914:Antibodies, Viral; D007978:Levamisole