Correlation of membrane phosphorylation and epidermal growth factor binding to hepatic membranes isolated from triiodothyronine-treated rats.
The in vivo administration of L-triiodothyronine to normal adult rats produced a reduction in the number of binding sites in hepatic membranes for epidermal growth factor; hyperthyroidism had no effect on insulin binding. The decreased receptor number correlated with a decrease in epidermal growth factor-stimulated phosphorylation of isolated hepatic membrane proteins (180 and 165 kDa) with adenosine [gamma-32P]triphosphate.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors; D008099:Liver / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects; D014284:Triiodothyronine / Q000494:pharmacology*
D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D014284:Triiodothyronine; D004815:Epidermal Growth Factor; D066246:ErbB Receptors