Diazepam inhibition of adenosine uptake in the CNS: lack of effect on adenosine kinase.
1. When tested at concentrations resulting in significant inhibitions of adenosine uptake in brain slices, diazepam and several other benzodiazepines were without effect on brain adenosine kinase. 2. This suggests that the inhibitory effect of the benzodiazepines on adenosine accumulation is at the membrane transport level and not by an inhibition of the intracellular phosphorylation step which facilitates adenosine uptake.
D000241:Adenosine / Q000378:metabolism*; D000248:Adenosine Kinase / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D004176:Dipyridamole / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D010770:Phosphotransferases / Q000037:antagonists & inhibitors*; D051381:Rats
D004176:Dipyridamole; D010770:Phosphotransferases; D000248:Adenosine Kinase; D000241:Adenosine; D003975:Diazepam