Influence of 13-cis-retinoic acid on mouse skin tumor initiation and promotion.
Tumor initiation in CD-1 mice by benzo[a]pyrene (BaP) or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was unaffected by topical pretreatment with 13-cis-retinoic acid (13-cis-RA). Likewise, anthralin-induced tumor promotion in SENCAR mice was unaffected by pretreatment with 13-cis-RA. These results suggest that the action of retinoids in preventing either tumor initiation or promotion is very carcinogen or cocarcinogen specific.
D000818:Animals; D000875:Anthralin / Q000633:toxicity; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000633:toxicity*; D005260:Female; D015474:Isotretinoin; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D051379:Mice; D010212:Papilloma / Q000139:chemically induced* / Q000517:prevention & control; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D013997:Time Factors; D014212:Tretinoin / Q000494:pharmacology*
D001580:Benzopyrenes; D008769:Methylnitronitrosoguanidine; D001564:Benzo(a)pyrene; D014212:Tretinoin; D015474:Isotretinoin; D000875:Anthralin