The modulation of the dorsal immobility response in the adult male Wistar rat: the opposite effects of ACTH4-10 and [D-Phe7]ACTH4-10.
A series of experiments were conducted to determine the behavioral effect of ACTH4-10 and [D-Phe7]ACTH4-10 on the dorsal immobility response (DIR) in adult male Wistar rats. Both peripheral and central injections of ACTH4-10 attenuated the duration of DIR, whereas, peripherally injected [D-Phe7]ACTH4-10 resulted in the potentiation of this response. The effect of peripherally administered ACTH4-10 was dose dependent in the range of 0.2 to 20 micrograms. These results, in part, extend the prior findings on the modulation of various learned and species-typical behaviors by ACTH-related peptides to a complex state of behavioral inhibition and immobility.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology* / Q000031:analogs & derivatives; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D010446:Peptide Fragments; C026384:ACTH (1-4); C034159:ACTH (4-10), Phe(7)-; D000324:Adrenocorticotropic Hormone