title: Toxicity testing of pertussis vaccines: effect of increased sensitivity of mice to Bordetella pertussis.
abstract: The increased sensitivity to Bordetella pertussis of a line of CD-1 mice used in toxicity-testing and the consequent and needless rejection of several lots of DPT vaccine are described. Apart from changes in the mice the possible presence of an infective agent in the animal house could not be discounted. The usefulness of individual mouse weights in the assay as opposed to group weights and of a reference preparation to monitor the performance of mice is discussed.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D001886:Bordetella pertussis / Q000472:pathogenicity*; D051379:Mice / Q000276:immunology*; D010567:Pertussis Vaccine / Q000633:toxicity*
chemical_list: D010567:Pertussis Vaccine