Leukotrienes produced by incubation of dihomo-delta-linolenic acid with human polymorphonuclear leukocytes.
Two new leukotrienes, 8,15-dihydroxy-9,11,13-icosatrienoic acid (8,15-LTB3) and 14,15-dihydroxy-8,10,12-icosatrienoic acid (14,15-LTB3) were identified in incubations of human polymorphonuclear leukocytes with dihomo-delta-linolenic acid (8,11,14-icosatrienoic acid). The yield of these compounds was very low (0.5% of the total radioactivity) and did not increase with indomethacin alone or in combination with ionophore A-23187. Stereochemistry and biologic activity of the two leukotrienes remain to be established.
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D007975:Leukotriene B4 / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification; D013058:Mass Spectrometry; D009504:Neutrophils / Q000378:metabolism*
D005231:Fatty Acids, Unsaturated; D007975:Leukotriene B4; C030722:8,15-leukotriene B4; C030723:14,15-leukotriene B4; D015126:8,11,14-Eicosatrienoic Acid