Lung involvement in scleroderma.
Lung involvement (LI) was studied by lung function (LF) in 101 scleroderma patients (circumscribed scleroderma, n = 17; progressive systemic scleroderma [PSS], n = 84; with the subtypes I, acroscleroderma [n = 19]; 2, proximal ascending scleroderma [n = 61]; 3, trunk scleroderma [n = 4]). Eighteen percent of morphea, 32 percent of type 1, 56 percent of type 2, and 75 percent of type 3 patients had impaired LF. The LI was more frequent (57 percent vs 45 percent) and more severe (20 percent vs 3 percent) in PSS with systemic inflammation (form A) compared to those without (form B). Elevated lymphocytes/neutrophils in bronchoalveolar lavage (BAL) were found associated with form A and severe LI. The LF of patients showing an inflammatory cell pattern in initial BAL (n = 3) worsened, whereas those with normal BAL findings (n = 4) did not. Collagenase activity in BAL was significantly elevated in those with elevated lymphocytes/neutrophils in lavage. Patients with type 2 or 3 of PSS, especially form A, carry a higher risk of developing severe LI than circumscribed scleroderma, type 1, or form B patients. Differential cell count and collagenase activity in BAL is correlated with active disease and provides prognostic information.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D001980:Bronchi / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000201:enzymology / Q000503:physiopathology*; D008297:Male; D003012:Microbial Collagenase / Q000032:analysis; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000473:pathology; D012129:Respiratory Function Tests; D012595:Scleroderma, Systemic / Q000097:blood / Q000201:enzymology / Q000503:physiopathology*; D012737:Sex Factors; D007507:Therapeutic Irrigation
D003012:Microbial Collagenase