title: Cross-resistance to human interferon-gamma of human interferon-beta-resistant F-IFr cells.
abstract: F-IFr cells, which are more resistant to the anticellular and antiviral action of human alpha and beta interferons (IFN-alpha and IFN-beta) than the parental RSa cells, were also found to be more resistant to both the anticellular and antiviral effect of IFN-gamma. A high level of 2-5A synthetase was induced by treatment with IFN-alpha or -beta, but induction of 2-5A synthetase was not detected after IFN-gamma treatment of the cells. F-IFr cells had less than half the number of specific binding sites for IFN-alpha than the parental RSa cells.
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis; D001358:Avian Sarcoma Viruses; D002460:Cell Line; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003429:Cross Reactions; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000037:antagonists & inhibitors / Q000276:immunology*; D007371:Interferon-gamma / Q000037:antagonists & inhibitors / Q000276:immunology*; D013539:Simian virus 40
chemical_list: D007370:Interferon Type I; D007371:Interferon-gamma; D015088:2',5'-Oligoadenylate Synthetase