[Significance of the hypothalamus opioid system in the mechanism of morphine analgesia].
It has been demonstrated in experiments on conscious rabbits that microinjections of nalorphine to the paraventricular area of the hypothalamus blocked morphine analgesia assessed from the tail-flick test and evoked potential variation in the sensorimotor area of the brain cortex in response to nociceptive electrocutaneous stimulation. An analogous but less powerful effect was produced by nalorphine injected into the large raphe nucleus. It is assumed that morphine analgesia is primarily mediated by opioid structures of the hypothalamus.
D000698:Analgesia; D000818:Animals; D004744:Enkephalin, Methionine / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009269:Nalorphine / Q000494:pharmacology*; D011817:Rabbits; D011903:Raphe Nuclei / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects; D013003:Somatosensory Cortex / Q000502:physiology
D011957:Receptors, Opioid; D004744:Enkephalin, Methionine; D009020:Morphine; D009269:Nalorphine
Znachenie opioidnoĭ sistemy gipotalamusa v mekhanizmakh morfinnoĭ anal'gezii.