Reconstitution of Semliki forest virus infected mice, induces immune mediated pathological changes in the CNS.
Reconstitution of Semliki forest virus infected nude mice with spleen cells from their immunocompetent nu/+ litter mates resulted in an abolition of the otherwise persistent brain virus, production of anti-SFV IgG, and development of normally absent brain pathology. The brain pathological changes, including demyelination, seem to be mediated by T cells, and are maximum 14 days after sensitization of the reconstituting spleen cells. Sensitization of the spleen cells 7 days before transfer to the nude mice results in pathological changes advanced by about 8 days, compared to reconstitution with unsensitized cells. The involvement of T cells in the virus-induced pathology is discussed.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001921:Brain / Q000382:microbiology / Q000473:pathology*; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008819:Mice, Nude; D012672:Semliki forest virus / Q000276:immunology / Q000302:isolation & purification; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D013997:Time Factors; D014036:Togaviridae Infections / Q000473:pathology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G