[New recommendations for the completion of rhesus-immunization prophylaxis with anti-D].
Despite the successful prevention of the Rhesus-isoimmunization in Rhesus-negative mothers after delivery of a Rhesus-positive child by immunoglobulin anti-D injected post partum, some women still get sensitized against the Rhesus-antigen by transplacental haemorrhages occurring during pregnancy or in miscarriages, abortions or ectopic pregnancies. Besides that, failures of the Rhesus-prophylaxis may be caused by large volumes of fetal blood transferred to the maternal circulation - especially in complicated deliveries. We therefore recommend to give immunoglobulin anti-D during pregnancy whenever there is a reported risk of significant transplacental haemorrhages. Further we urge to count the fetal cells in the maternal blood after each delivery to adjust the anti-D-dosage to the volume of the transplacental haemorrhage.
D000022:Abortion, Spontaneous / Q000150:complications; D001787:Blood Group Incompatibility / Q000097:blood / Q000209:etiology / Q000628:therapy*; D001788:Blood Grouping and Crossmatching; D004306:Dose-Response Relationship, Immunologic; D004899:Erythroblastosis, Fetal / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005331:Fetomaternal Transfusion / Q000150:complications; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis; D049590:Postpartum Period; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D018029:Rho(D) Immune Globulin
D007136:Immunoglobulins; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin
Neue Empfehlungen zur Durchführung der Rhesusprophylaxe mit Anti-D.