title: Laminal distribution of gamma-aminobutyric acid (GABA) in the occipital cortex of rats: evidence as a neurotransmitter.
abstract: The laminal distribution of gamma-aminobutyric acid (GABA) in the rat occipital cortex was determined by an enzymatic procedure following decapitation or microwave irradiation (5 kW for 1.1 s). No significant differences were observed in the concentrations of GABA among 5 layers after microwave irradiation. However, when the animals were sacrificed by decapitation, the concentrations varied among the layers with the highest being detected in the internal granular layer (lamina IV) followed by the external granular (II), external pyramidal (III) and internal pyramidal layers (V). In these layers, GABA was significantly higher than in the other two layers, the molecular (I) and multiform layers (VI). The results are discussed in terms of the neurotransmitter function of GABA in the occipital cortex.
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D008297:Male; D009433:Neural Inhibition; D009474:Neurons / Q000201:enzymology / Q000648:ultrastructure; D009778:Occipital Lobe / Q000033:anatomy & histology* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase