Electrophysiological effects of angiotensin II on cultured mouse spinal cord neurons.
The effects of angiotensin II (AII) on the membrane properties of cultured spinal neurons were investigated using electrophysiological methods. In 26% of neurons tested AII induced changes in membrane potential and input resistance which varied according to the concentration of applied peptide. At low concentrations (10(-6) M), AII increased input resistance by an ionic mechanism which appears to involve a reduction in Cl- conductance. At higher concentration (10(-4) M), AII evoked depolarization associated with a decrease in input resistance. This response appears to depend on an increase in Na+ conductance. Our observations indicate that AII can have multiple effects on neuronal membrane properties dependent on the concentration of applied peptide.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002712:Chlorides / Q000378:metabolism; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D007473:Ion Channels / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009474:Neurons / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D002712:Chlorides; D007473:Ion Channels; D000804:Angiotensin II