Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation.
We demonstrate here that drugs which inactivate cytochrome c oxidase are able to segregate cardiolipin essential for the enzyme activity, in a separate phase inaccessible for the enzyme. A molecular explanation of the drug-induced aggregation process is proposed.
D000165:Acridine Orange / Q000494:pharmacology*; D000818:Animals; D002152:Calorimetry, Differential Scanning; D002308:Cardiolipins / Q000378:metabolism*; D002417:Cattle; D004317:Doxorubicin / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors*; D004996:Ethidium / Q000494:pharmacology*; D008081:Liposomes; D046911:Macromolecular Substances; D008929:Mitochondria, Heart / Q000201:enzymology*; D011663:Pulmonary Surfactants
D002308:Cardiolipins; D008081:Liposomes; D046911:Macromolecular Substances; D011663:Pulmonary Surfactants; D004317:Doxorubicin; D003576:Electron Transport Complex IV; D004996:Ethidium; D000165:Acridine Orange