Investigations of the turnover of adrenocortical mitochondria. XVI. Effects of ethidium bromide on the ACTH-induced elongation of the half-life of rat zona fasciculata mitochondria.
ACTH significantly increases the half-life of rat zona fasciculata mitochondria. Since ethidium bromide inhibits this effect of ACTH, the hypothesis is advanced that the ACTH-induced slowing-down of the degradation rate of adrenocortical mitochondria involves mitochondrial DNA reduplication and transcription.
D000302:Adrenal Cortex / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000378:metabolism; D004996:Ethidium / Q000494:pharmacology*; D006207:Half-Life; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000324:Adrenocorticotropic Hormone; D004247:DNA; D004996:Ethidium