Inhibition of stress ulcer formation by aminophylline in rats.
The preventive effect of aminophylline in the development of stress ulcer by cold restraint was examined in Sprague-Dawley rats. Aminophylline, in a dose of 0.5 mg/kg, significantly inhibited stress ulcer formation in comparison to the control group. The preventative effect of aminophylline appeared to result from the inhibition of thrombus formation produced by the inhibition of platelet aggregation.
D000628:Aminophylline / Q000627:therapeutic use*; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000503:physiopathology; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000503:physiopathology; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological
D000628:Aminophylline; D000242:Cyclic AMP