Inhibition of acid secretion in the rat isolated stomach preparation by 5-hydroxytryptamine.
The effect of 5 hydroxytryptamine (5-HT) on gastric acid secretion by the rat isolated stomach has been studied. 5-HT (10 microM) significantly inhibited secretory responses to pentagastrin, histamine and isoprenaline but not those due to bethanechol, dibutyryl cyclic AMP or a phosphodiesterase inhibitor. The response was antagonized by methysergide (25 microM), indomethacin (28 microM) and ibuprofen (240 microM) but not by TTX (1 microM). It is concluded that 5-HT can exert a direct, inhibitory effect on acid secretion by the rat stomach and that this may involve the products of cyclo-oxygenase activity.
D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007052:Ibuprofen / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000494:pharmacology
D001626:Bethanechol Compounds; D011743:Pyrimidines; C006313:ICI 63197; D012701:Serotonin; D013779:Tetrodotoxin; D003994:Bucladesine; D006632:Histamine; D010418:Pentagastrin; D007545:Isoproterenol; D007052:Ibuprofen; D007213:Indomethacin; D008784:Methysergide