[Effect of T-2 toxin on the activity of organelle-specific enzymes of various rat organs].
Dynamics of 5 marker enzymes activity from subcellular particles--succinate dehydrogenase, beta-glucosidase, arylsulphatases A and B, acid RNAase and glucose-6-phosphatase--were studied in liver, spleen, thymus and blood serum of rats after single intragastric administration of T-2 toxin at a dose of 3.8 mg/kg (LD50). The acute intoxication was accompanied by an early (within 1-3 hrs) and significant reduction of total proteins in the tissues studied. Distinct tissue- and organelle-tropic effects of T-2 toxin were found: the toxin induced a gradual decrease in activity of the enzymes studied in liver tissue, while selective activation of lysosomal hydrolases was observed in spleen and thymus tissues. The selective effect of T-2 toxin on spleen and thymus lysosomal hydrolases appear to be involved in the mechanism of action of the toxin.
D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009928:Organ Specificity; D009940:Organoids / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism; D012717:Sesquiterpenes / Q000494:pharmacology*; D013154:Spleen / Q000201:enzymology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013605:T-2 Toxin / Q000494:pharmacology*; D013950:Thymus Gland / Q000201:enzymology; D001617:beta-Glucosidase / Q000378:metabolism
D012717:Sesquiterpenes; D013385:Succinate Dehydrogenase; D012260:Ribonucleases; D005952:Glucose-6-Phosphatase; D001192:Arylsulfatases; D001617:beta-Glucosidase; D013605:T-2 Toxin
Deĭstvie T-2 toksina na aktivnost' organellospetsificheskikh fermentov razlichnykh organov krys.