Are beta-adrenoreceptors involved in the intestinal absorption and tissue distribution of iron in the rat?
59Fe was incorporated in vivo into intestinal sacs prepared in iron deficient rats and 59Fe counts were detected in blood, spleen, liver, femur and intestine. The i.v. injection of isoproterenol (i.v. 2 micrograms/rat) or N',O'-dibutyryladenosine 3',5'-cyclic monophosphate (10 microM/100 g b.w.) enhanced significantly the iron counts in blood, spleen, liver and femur but not in intestine. (-)-Propranolol (2 mg X kg-1 b.w. i.v.) antagonized the stimulatory effect of isoproterenol. It is suggested that isoproterenol increases iron absorption via the stimulation of beta-adrenoreceptors of the intestinal mucosa.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D007504:Iron Radioisotopes; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D014018:Tissue Distribution
D007504:Iron Radioisotopes; D011943:Receptors, Adrenergic, beta; D003994:Bucladesine; D011433:Propranolol; D007501:Iron; D007545:Isoproterenol