title: Leukotrienes (LTB4 and LTD4): in vitro effects on human lymphocyte proliferation and transformation.
abstract: The effects of leukotrienes LTD4 and LTB4 on cell proliferation were assessed in a human in vitro lymphocyte transformation assay in the presence of optimal concentrations of PHA, Con A and PWM. Leukotriene D4 and LTB4 (10(-6) to 10(-11) M) did not alter the basal or mitogen-stimulated response. We therefore conclude that these two agents do not play a role in the modulation of human lymphocyte blastogenesis.
mesh_terms: D006801:Humans; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology; D013189:SRS-A / Q000494:pharmacology*
chemical_list: D008934:Mitogens; D013189:SRS-A; D007975:Leukotriene B4