title: [Use of angiotensin converting enzyme inhibitor captopril and peripheral vasodilator minoxidil in the treatment of patients with stable and malignant arterial hypertension].
abstract: Captopryl was used in 30 patients with different clinical forms of arterial hypertension (AH). Eight patients had the malignant arterial hypertension syndrome. Blood pressure became normal in 8, decreased in 9 and did not respond to hypotensive treatment in 2 patients. The drug was discontinued due to intolerance in 1 patient. In the course of captopryl treatment, natriuresis increased, potassium concentration increased in the plasma and decreased in the urine, plasma renin activity and aldosterone level increased. Minoxidil was used in 48 patients with AH of varying clinical forms, 19 of those having the malignant AH syndrome. The hypotensive effect of treatment was satisfactory. Minoxidil used as the sole therapeutic agent resulted in increased heart rate and plasma renin activity, and retention of fluids, which disappeared after beta-adrenoblockers and diuretics were added. Patients with the malignant hypertension syndrome showed a reduction, and sometimes disappearance, of retinal ischemic and hemorrhagic foci within 15-19 days of minoxidil treatment, or at the end of the treatment course with captopryl.
mesh_terms: D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000806:Angiotensin-Converting Enzyme Inhibitors; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D006974:Hypertension, Malignant / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000627:therapeutic use*; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives*; D011743:Pyrimidines / Q000627:therapeutic use*; D012083:Renin / Q000097:blood; D014665:Vasodilator Agents
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D011743:Pyrimidines; D014665:Vasodilator Agents; D000450:Aldosterone; D008914:Minoxidil; D011392:Proline; D002216:Captopril; D012083:Renin; D011188:Potassium
vernacular_title: Primenenie ingibitora angiotenzin-konvertiruiushchego fermenta kaptoprila i perifericheskogo vazodilatatora minoksidila pri lechenii bol'nykh so stabil'nym i zlokachestvennym techeniem arterial'noĭ gipertenzii.