title: Multimodality treatment of adenocarcinoma of the vagina Stage IV: potential for cure.
abstract: A 26-year-old nulligravida presented with a Stage IV adenocarcinoma of the vagina with a frozen pelvis and positive lymph nodes in the right external iliac and inguinal regions. Following transposition of the ovaries laterally, a successful treatment program of cyclic radiotherapy and 5-fluorouracil was undertaken. Patient is now alive 3 years posttherapy with a functional vagina, return of menses, and without evidence of tumor. She experienced a small-bowel stricture 5 months posttherapy which required small-bowel resection. This case suggests that an integrated multimodality program is feasible and that 5-fluorouracil may be synergistic with radiation.
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000532:radiotherapy / Q000628:therapy*; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D014625:Vaginal Neoplasms / Q000532:radiotherapy / Q000628:therapy*
chemical_list: D005472:Fluorouracil