Terferol, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. I. Isolation and characterization.
Terferol, a new inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase (EC 3.1.4.17, cAMP-PDE), was isolated from the cultured broth of Streptomyces showdoensis SANK 65080. It was found to have the molecular formula C19H16O3 and to possess inhibitory activity not only against cAMP-PDE but also against cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP-PDE) from various rat tissues. The terferol concentration required for 50% inhibition of cAMP-PDE was 0.82 microM.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D005285:Fermentation; D007700:Kinetics; D051381:Rats; D013302:Streptomyces / Q000032:analysis; D013730:Terphenyl Compounds / Q000302:isolation & purification* / Q000494:pharmacology
D013730:Terphenyl Compounds; C040546:terferol; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases