Behavior and binding: desensitization to alpha 1-adrenergic stimulation of acoustic startle is associated with a decrease in alpha 1-adrenoceptor binding sites.
Desensitization of the excitatory effects of alpha 1-adrenergic agonists on acoustic startle occurred 6 h after intrathecal administration of the alpha 1-adrenergic agonist, phenylephrine. This desensitization was associated with a decrease in alpha 1-adrenoceptor sites in the lumbar spinal cord.
D000161:Acoustic Stimulation; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D009622:Noise; D010656:Phenylephrine / Q000494:pharmacology*; D011224:Prazosin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000378:metabolism*; D013216:Reflex, Startle / Q000187:drug effects*; D013116:Spinal Cord / Q000502:physiology; D013331:Strychnine / Q000494:pharmacology
D008732:Methoxydimethyltryptamines; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D013331:Strychnine; D011224:Prazosin