Significance of high percentages of S-phase cells in human pituitary tumours.
Using the flow-cytofluorometric technique, 47 consecutive cases of pituitary tumours were analyzed regarding DNA ploidy and the percentage of cells in different phases of the cell cycle. About 20,000-30,000 cells from each tumour were analyzed. Tumours causing acromegaly showed a higher incidence of high percentages of S-phase cells (greater than or equal to 10%) than any other endocrinological type of pituitary tumour. 3 of 6 tumours with high percentages of S-phase cells showed clinically aggressive growth patterns.
D000172:Acromegaly / Q000209:etiology; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000368:Aged; D000782:Aneuploidy; D002453:Cell Cycle; D002455:Cell Division; D002648:Child; D004273:DNA, Neoplasm / Q000235:genetics; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D011388:Prolactin / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism
D004273:DNA, Neoplasm; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone