Severe hepatitis during ketoconazole therapy.
Ketoconazole is an imidazole derivative recently developed as an antifungal agent. There have been only a few established cases of hepatotoxicity in the literature. This report describes a case of presumed ketoconazole hepatotoxicity characterized by the development of severe hepatitis with marked centrilobular necrosis. The lack of hypersensitivity reactions in clinical findings and centrilobular location of necrosis suggested a host idiosyncrasy with metabolic abnormality as the effect of ketoconazole in the present case.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000935:Antifungal Agents / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D003881:Dermatomycoses / Q000188:drug therapy; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D007654:Ketoconazole; D008099:Liver / Q000187:drug effects / Q000473:pathology; D010879:Piperazines / Q000009:adverse effects*
D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D007654:Ketoconazole