The role of pre-synaptic GABA and benzodiazepine receptors in the control of noradrenaline release in rat hippocampus.
Noradrenaline release from synaptosomes of rat hippocampus is modulated by both GABA and benzodiazepines. GABAA and GABAB receptors are present on these nerve terminals, and agonists at these receptors enhance spontaneous release and depress K+ -evoked release, respectively. Chlordiazepoxide has a dual effect: it enhances the action of GABA at GABAA receptors and depresses K+ -evoked release of [3H]noradrenaline in the absence of GABA. The mechanism of these actions and their in vivo role are discussed.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002707:Chlordiazepoxide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology*; D011963:Receptors, GABA-A; D013574:Synaptosomes / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D000001:Calcimycin; D005680:gamma-Aminobutyric Acid; D002707:Chlordiazepoxide; D011188:Potassium; D009638:Norepinephrine