New world primates as a model of viral-induced astrocytomas.
Owl and squirrel monkeys are susceptible to the oncogenic effects of JCV. These species of New World monkeys can be safely inoculated intracerebrally. Care must be taken with owl monkeys since they have an inherited clotting abnormality. Incubation times for the development of tumors range from 14 to 30 months. Anorexia was the first clinical sign of tumor development. The clinical course is rapid with death within two to three days. This model provides a means for studying diagnostic, virological, immunological and therapeutic techniques which are applicable to human patients with astrocytomas.
D000818:Animals; D001029:Aotus trivirgatus; D001254:Astrocytoma / Q000382:microbiology*; D001932:Brain Neoplasms / Q000382:microbiology*; D002427:Cebidae; D004195:Disease Models, Animal; D007577:JC Virus / Q000472:pathogenicity*; D008992:Monkey Diseases / Q000382:microbiology*; D011120:Polyomavirus / Q000472:pathogenicity*; D012453:Saimiri; D014412:Tumor Virus Infections / Q000382:microbiology*