title: Cloning and sequencing of a full length cDNA coding for human retinol-binding protein.
abstract: We have isolated and sequenced a cDNA clone coding for human Retinol Binding Protein. The sequence indicates that Retinol Binding Protein is synthesized as a single polypeptide chain precursor which is then matured to the secreted protein by removal of a leader peptide. Southern and Northern blot analysis suggest that the gene is present in one or few copies per haploid genome and is transcribed in a single mRNA species.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism*; D004262:DNA Restriction Enzymes; D005260:Female; D005333:Fetus; D005796:Genes; D006801:Humans; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D011247:Pregnancy; D012177:Retinol-Binding Proteins / Q000235:genetics*
chemical_list: D012177:Retinol-Binding Proteins; D004247:DNA; D004262:DNA Restriction Enzymes