Synthesis of cytochrome c oxidase in the liver of Rana catesbeiana tadpole treated with griseofulvin.
The effect of griseofulvin treatment on the synthesis of cytochrome c oxidase was studied with the liver of the tadpole, Rana catesbeiana. (1) In the liver of tadpole treated with griseofulvin, a ferrochelatase inhibitor, the synthesis of heme a, but not cytochrome c oxidase protein, is inhibited. (2) The apocytochrome c oxidase which is formed in the liver of tadpole treated with griseofulvin is converted to the active holoenzyme by exogenously added heme a.
D000818:Animals; D001051:Apoenzymes / Q000096:biosynthesis; D003576:Electron Transport Complex IV / Q000096:biosynthesis*; D006118:Griseofulvin / Q000494:pharmacology*; D006418:Heme / Q000096:biosynthesis* / Q000378:metabolism; D007814:Larva; D008930:Mitochondria, Liver / Q000201:enzymology; D011892:Rana catesbeiana
D001051:Apoenzymes; D006118:Griseofulvin; D006418:Heme; D003576:Electron Transport Complex IV