Human natural cytotoxic cell activity: enhancement by leukotrienes (LT) A4, B4 and D4, but not by stereoisomers of LTB4 or HETES.
Natural cytotoxic activity of human lymphocytes was significantly enhanced by incubation with LTA4, LTB4 or LTD4. In contrast, stereoisomers of LTB4 as well as 5-HETE and 12-HETE were not active. These findings suggest that leukotrienes may play an important role in host defense mechanisms.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D001095:Arachidonic Acids / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D007975:Leukotriene B4 / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D013189:SRS-A / Q000494:pharmacology*; D013237:Stereoisomerism
D001095:Arachidonic Acids; D013189:SRS-A; D007975:Leukotriene B4; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid