Effects of beta-receptor blockers in pharmacology EEG.
10 normal volunteers (5 females, 5 males, 18-30 years) were treated for 4 days with the beta-blocker sotalol, 320 or 960 mg/day, 5 persons each in random order. A placebo was applied 5 days before and 2 days afterwards. Changes in blood pressure and pulse were not pronounced. EEG data from vigilance-controlled EEGs, evaluated in a spectral parameter analysis, showed a significant decrease of the absolute and relative alpha-power and the dominant alpha-amplitude and so far indicate a central nervous system action of sotalol.
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000379:methods*; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008297:Male; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013015:Sotalol / Q000097:blood / Q000494:pharmacology*
D011943:Receptors, Adrenergic, beta; D013015:Sotalol