Cholecystokinin-octapeptide-induced hyperthermia in guinea-pigs.
Intracerebroventricular administration of cholecystokinin-octapeptide (CCK-8) at room temperature (21 degrees C) induced dose-related hyperthermia in guinea-pigs and also produced hyperthermia at low (10 degrees C) and high (30 degrees C) ambient temperatures. CCK-8-induced hyperthermia was direct and not mediated by prostaglandins, norepinephrine, cyclic AMP or naloxone-sensitive receptors.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007213:Indomethacin / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D012844:Sincalide / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology
D010643:Phenoxybenzamine; D009270:Naloxone; D013806:Theophylline; D012844:Sincalide; D007213:Indomethacin