title: DNA gyrase (Topoisomerase II) from Pseudomonas aeruginosa.
abstract: DNA gyrase (Topoisomerase II) has been purified from Pseudomonas aeruginosa strain PAO. This enzyme is inhibited by novobiocin and nalidixic acid. DNA gyrase from P. aeruginosa is resistant to a much higher level of nalidixic acid than is Escherichia coli DNA gyrase. This increased level of resistance may explain, at least in part, the higher levels of natural resistance exhibited by P. aeruginosa toward nalidixic acid.
mesh_terms: D001426:Bacterial Proteins / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D004250:DNA Topoisomerases, Type II / Q000302:isolation & purification*; D004352:Drug Resistance, Microbial; D009268:Nalidixic Acid / Q000494:pharmacology; D009675:Novobiocin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000201:enzymology*; D059005:Topoisomerase II Inhibitors
chemical_list: D001426:Bacterial Proteins; D059005:Topoisomerase II Inhibitors; D009675:Novobiocin; D009268:Nalidixic Acid; D004250:DNA Topoisomerases, Type II