Toxic and transforming effects of cigarette smoke condensates in fetal Syrian golden hamster lung cell cultures.
The cytotoxic and transforming effects of cigarette smoke condensates (CSCs) and benzo(a)pyrene (BaP) were compared using cultures of fetal Syrian golden hamster lung cells (FSHL). The dose-response patterns differed completely between CSCs and BaP. The amount of BaP alone failed to explain the transforming activity of CSCs.
D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D006224:Cricetinae; D005333:Fetus; D008168:Lung; D008647:Mesocricetus; D010947:Plants, Toxic; D012906:Smoke; D014026:Nicotiana
D001580:Benzopyrenes; D002273:Carcinogens; D012906:Smoke; D001564:Benzo(a)pyrene