[Molecular model of the regulation of chemical synapse efficiency at the postsynaptic level].
The regulation of efficacy of a chemical synapse at the postsynaptic level is discussed in terms of the reversible allosteric transitions of the receptor for the neurotransmitter. The proposed model accounts for the regulation of a synapse by its own state of activity and by that of neighbouring synapses on the same neuron. The model predicts persisting changes of efficacy in the time-scale of seconds-minutes compatible with short-term memory processes following, in particular, the scheme of classical conditioning.
D000818:Animals; D003214:Conditioning, Classical; D007700:Kinetics; D008564:Membrane Potentials; D008568:Memory; D008959:Models, Neurological; D008960:Models, Psychological; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
Un modèle moléculaire de régulation d'efficacité au niveau postsynaptique d'une synapse chimique.