Phenothiazines mimic the action of cAMP in potentiating slow inward current in a bursting molluscan neuron.
Trifluoperazine and chlorpromazine, blockers of calmodulin action, potentiate slow inward current in molluscan neurons identically to the action of cAMP. The sulfoxide derivative of chloropromazine does not appreciably bind to calmodulin and also fails to enhance the inward current. The likelihood that these effects are mediated by cAMP via inhibition of a Ca2+-calmodulin-activated phosphodiesterase is discussed and related to other data.
D000818:Animals; D002147:Calmodulin / Q000378:metabolism*; D002746:Chlorpromazine / Q000031:analogs & derivatives / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D005724:Ganglia / Q000187:drug effects*; D066298:In Vitro Techniques; D010640:Phenothiazines / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D012908:Snails; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D010640:Phenothiazines; C026714:opromazine; D014268:Trifluoperazine; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D002746:Chlorpromazine