[Results of treatment with growth hormone. Apropos of 31 cases of pituitary insufficiency].
The results of treatment with human growth hormone in 31 children with hypopituitarism are reported. 19 boys and 12 girls were treated for several years, six years in three instances. Pituitary insufficiency was idiopathic in 23 cases (isolated in 11 and associated with other deficiencies in 12) and secondary in 8 cases. The mean statural gain during the first year of treatment was 6.3 +/- 2.2 cm with a mean dosage of 9.3 +/- 4 mg/kg/year. The parameters which have the most bearing on statural gain during the first year are: dosage (p less than 0.001) which must be at least equal to 8 mg/kg/year, bone age and chronologic age. In subsequent years statural gain is less significant and seems to be dependent upon the same parameters.
D000293:Adolescent; D000367:Age Factors; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy* / Q000209:etiology; D008297:Male
D013006:Growth Hormone
Résultats du traitement par l'hormone de croissance. A propos de trente et une observations d'insuffisance hypophysaire.