[Effect of naloxone on polyphosphoinositide in erythrocytes of spontaneously hypertensive rats].
We investigated the in vitro action of naloxone (1 X 10(-6) M) on the content and 32P incorporation into di-and triphosphoinositides of erythrocytes from spontaneously hypertensive rats (SHR) and WKY controls (both 10 weeks of age). We found that the content of diphosphoinositides was decreased and the specific activity of their phosphate groups was increased after incubation with naloxone for 1 min in both rat strains. The effect was faster in SHR than in WKY rats.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006973:Hypertension / Q000097:blood*; D009270:Naloxone / Q000494:pharmacology*; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000097:blood*; D051381:Rats; D011922:Rats, Mutant Strains
D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D009270:Naloxone
Wirkung von Naloxon auf Polyphosphoinositide der Erythrozyten spontan hypertoner Ratten.