Diffuse nonlobular ovarian androblastoma usually associated with feminization.
The unusual pleomorphism of ovarian androblastoma calls for the definition of further subgroups and fuller use of the available interpretative ideas. A set of six cases forming a possible subgroup is presented. Functionally these were mainly estrogenic. Structurally they showed a diffuse fibrothecomatous or thecogranulosal background with foci of limited and sexually equivocal differentiation. Lutein cell clusters were present in all cases and tubules were present in five. The ideas developed for interpreting the androblastoma family are reviewed historically and related to the foregoing. The criteria of testicular differentiation, and the relation of endocrine function to morphology and age, are discussed.
D000328:Adult; D000368:Aged; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D010053:Ovary / Q000473:pathology; D018310:Sertoli-Leydig Cell Tumor / Q000378:metabolism / Q000473:pathology*
D004967:Estrogens