Cannabinoids in glaucoma II: the effect of different cannabinoids on intraocular pressure of the rabbit.
Thirty-two different cannabinoids were tested for their ability to reduce intraocular pressure (IOP) in the rabbit. These included many of delta 9- and delta 8-THC derivatives and metabolites along with other natural and synthetic cannabinoids. In addition, some non-cannabinoid constituents of Cannabis were screened using the same model. All compounds were administered intravenously, while only a few were tested topically in mineral oil. Water soluble derivatives of delta 9- and delta 8-THC were prepared and tested topically in aqueous solution. The data revealed that certain derivatives of delta 9-and delta 8-THC were more active in lowering IOP than the parent cannabinoids. In addition, compounds other than delta 9- and delta 8-THC and their derivatives were shown to have activity.
D000287:Administration, Topical; D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology / Q000627:therapeutic use*; D013759:Dronabinol / Q000494:pharmacology / Q000031:analogs & derivatives; D005901:Glaucoma / Q000188:drug therapy*; D007429:Intraocular Pressure / Q000187:drug effects*; D011817:Rabbits; D013329:Structure-Activity Relationship
D002186:Cannabinoids; C035731:delta-8-tetrahydrocannabinol; D013759:Dronabinol; C010695:cannabichromene