Differential effects of the enantiomers of 3-PPP on dopamine D1-receptors of isolated rabbit retina.
The effects of (+)- and (-)-3-PPP on cAMP levels of rabbit retina were investigated in vitro in the absence or presence of exogenous dopamine. In some experiments, a pre-incubation with reserpine was undertaken to deplete endogenous dopamine before the test. (+)- and (-)-3-PPP were found to be a weak dopamine-agonist and a weak dopamine-antagonist, respectively. Thus, the 3-PPP enantiomers may have opposite actions at the level of postsynaptic dopamine receptors, as previously suggested by studies in vivo.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007536:Isomerism; D010880:Piperidines / Q000494:pharmacology*; D011817:Rabbits; D011954:Receptors, Dopamine / Q000187:drug effects*; D017447:Receptors, Dopamine D1; D012160:Retina / Q000187:drug effects* / Q000378:metabolism
D010880:Piperidines; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; C026539:preclamol; D000242:Cyclic AMP; D004298:Dopamine