Tonic and phasic INa blockade by antiarrhythmics. Different properties of drug binding to fast sodium channels as judged from Vmax studies with propafenone and derivatives in mammalian ventricular myocardium.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006329:Heart Conduction System / Q000187:drug effects*; D007424:Intracellular Fluid / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D010210:Papillary Muscles / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D011405:Propafenone / Q000031:analogs & derivatives; D011427:Propiophenones / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D011427:Propiophenones; D013779:Tetrodotoxin; D011405:Propafenone; C037836:SA 76; C037837:butafenone; D012964:Sodium; D011188:Potassium