A diet enriched with eicosapentaenoic acid suppresses autoimmune nephritis in female (NZB x NZW) F1 mice.
A diet containing menhaden oil, rich in EPA, protected (NZB x NZW) F1 mice from developing lupus nephritis. Only 16% of mice treated with this diet from 5-6 weeks of age developed severe renal disease by 19 months of age, as opposed to 100% of controls. The menhaden oil diet, when delayed until mice were 5 months of age, also reduced the incidence of renal disease, and under these conditions anti-n-DNA and anti-ss-DNA antibodies were similar in treated and control groups. We suggest that EPA, an AA analogue, may reduce inflammation by altering the production of PGs and LTs.
D000367:Age Factors; D000818:Animals; D001327:Autoimmune Diseases / Q000178:diet therapy / Q000517:prevention & control*; D004247:DNA / Q000276:immunology; D004041:Dietary Fats / Q000627:therapeutic use*; D004044:Dietary Proteins / Q000627:therapeutic use; D015118:Eicosapentaenoic Acid; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005260:Female; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D009393:Nephritis / Q000178:diet therapy / Q000473:pathology / Q000517:prevention & control*
D004041:Dietary Fats; D004044:Dietary Proteins; D005231:Fatty Acids, Unsaturated; D004247:DNA; D015118:Eicosapentaenoic Acid