title: Decrease in the average size of replicons in a Werner syndrome cell line by Simian virus 40 infection.
abstract: We have measured the distance between replicon initiation sites as well as the rate of DNA chain elongation in Simian Virus 40 (SV40)-infected and uninfected Werner syndrome (WS) and normal cell lines by DNA fiber-autoradiography. There was no difference in the rate of chain elongation among these cell lines. On the other hand, the replicon center-to-center distance was clearly longer in WS fibroblasts than that in normal fibroblasts. SV40 infection changed the center-to-center distance in WS cells toward that in normal cells.
mesh_terms: D001345:Autoradiography; D002460:Cell Line; D004261:DNA Replication; D005347:Fibroblasts / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D012093:Replicon; D013539:Simian virus 40 / Q000502:physiology*; D014898:Werner Syndrome / Q000378:metabolism* / Q000382:microbiology