Quantitative relationship between post-tetanic biochemical and electrophysiological changes in rat hippocampal slices.
Slices of rat brain hippocampus were tetanized in the perforant path fibers. In individual slices long-term changes of the electrophysiological parameters were determined simultaneously with post hoc endogeneous phosphorylation of proteins in a lyzed crude mitochondrial/synaptosomal fraction. A quantitative relation between the electrophysiological parameters and the degree of phosphorylation of a 52K protein was found to follow a non-linear function.
D000200:Action Potentials; D000818:Animals; D004594:Electrophysiology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
D009419:Nerve Tissue Proteins