title: Further studies on the immunization of chickens with temperature-sensitive Mycoplasma gallisepticum mutant.
abstract: Newly hatched chickens were immunized with a temperature-sensitive (TS) Mycoplasma gallisepticum (MG) mutant (TS 100). Immunized chickens resisted challenge with the virulent S6 strain. The dose of TS MG needed for protection was less than 3.3 X 10(4) colony-forming units. After immunization with TS 100, chickens were subjected to a variety of virus infection and immunosuppressive treatments. Neonatal bursectomy or thymectomy, infectious bursal disease virus infection, and infectious bronchitis virus vaccination or a combination of infectious bronchitis virus and Newcastle disease virus vaccination did not contribute to the development of air-sac lesions in TS MG-immunized chickens. Infectious bronchitis virus vaccination enabled MG to migrate from the nasal cavity to the trachea but not to the air sacs. The TS MG vaccine appears to be a safe immunogen.
mesh_terms: D000400:Air Sacs; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D001351:Infectious bronchitis virus / Q000276:immunology; D007243:Infectious bursal disease virus / Q000276:immunology; D009174:Mycoplasma / Q000276:immunology; D009175:Mycoplasma Infections / Q000276:immunology* / Q000473:pathology / Q000662:veterinary; D009522:Newcastle disease virus / Q000276:immunology; D011201:Poultry Diseases / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology* / Q000473:pathology / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D014765:Viral Vaccines