In vitro immunization against autologous glioblastoma cells coupled to adjuvant peptide.
A glioblastoma patient was immunized in vitro against autologous tumor cells. Tumor cell immunogens coupled to adjuvant peptide induced direct cell-mediated cytotoxicity, which was measured with a short-term 51chromium release assay. Plain tumor cells were non-antigenic. Cytotoxicity was largely eliminated by erythrocyte-sedimentation of effectors. These results suggest the feasibility of immunizing glioblastoma patients against autologous tumor-associated antigens.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology*; D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D000951:Antigens, Neoplasm / Q000276:immunology*; D001932:Brain Neoplasms / Q000276:immunology* / Q000628:therapy; D003131:Combined Modality Therapy; D005909:Glioblastoma / Q000276:immunology* / Q000628:therapy; D006801:Humans; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000951:Antigens, Neoplasm; D000119:Acetylmuramyl-Alanyl-Isoglutamine