Facilitation and inhibition of plasma cortisol following electrical stimulation of the goldfish forebrain.
To examine the role of forebrain structures in the control of ACTH release, electrical stimulation was performed in the brains of continuously respirated , immobilized goldfish in which endogenous ACTH release was suppressed with dexamethasone. Three active areas of the forebrain were identified. Electrical stimulation for 5 min resulted in elevations of plasma cortisol 15 min following stimulation of the nucleus preopticus (NPO) or of the nucleus tenia (NT) but a decrease in plasma cortisol following stimulation of the nucleus lateral tuberis (NLT). The results of this study demonstrate that the NPO and NT facilitate, whereas nerve fibers originating in or passing through the NLT inhibit, ACTH release in the goldfish.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D004558:Electric Stimulation; D006054:Goldfish; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011301:Preoptic Area / Q000502:physiology; D009435:Synaptic Transmission
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone