[Metabolic reaction of leukocytes in the course of experimental traumatic shock of varying intensity and on exposure to obzidan].
In stress-resistant animals exposed to 5-minute immobilization, the metabolic reaction of leukocytes was marked by an increase in the activity of G-6-PDH, hexokinase (HK), cytochrome oxidase (CCO) accompanied by a decrease in the activity of succinate dehydrogenase (SDH). In stress-labile animals, there was a decrease in the activity of G-6-PDH, HK, CCO with an increase in the activity of SDH. The orientation of enzymatic processes in leukocytes of stress-labile animals after immobilization and of stress-resistant animals following intravenous injection of propranolol was discovered to be similar. After propranolol injection leukocytes did not show any glucose, while the activity of G-6-PDH, HK and CCO descended. Injection of propranolol decreased the animal's resistance to traumatic shock. In stress-resistant animals exposed to trauma after the blockade of beta-adrenoreactive structures, the metabolic reaction was marked by low mobility restitution of energy processes as was the case in stress-labile animals during the development of a severe shock.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D003576:Electron Transport Complex IV / Q000097:blood; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006593:Hexokinase / Q000097:blood; D007773:Lactates / Q000097:blood; D007958:Leukocyte Count; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood; D012774:Shock, Traumatic / Q000097:blood*; D013385:Succinate Dehydrogenase / Q000097:blood
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D011433:Propranolol; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D003576:Electron Transport Complex IV; D006593:Hexokinase
Metabolicheskaia reaktsiia leĭkotsitov pri raznoĭ tiazhesti techeniia éksperimental'nogo travmaticheskogo shoka i deĭstvii obzidana.