Lack of uptake of indocyanine green and trypan blue by hepatocellular carcinoma.
Experimental hepatocellular carcinoma (HCC) in rats did not take up intravenously administered indocyanine green (ICG) and trypan blue, while surrounding tissue did. The lack of ICG uptake was also observed by peritoneoscopy in patients with HCC. The contrast between ICG-stained cirrhotic nodules and HCC tumors was intensified with infrared photography. Non-uptake of dyes by HCC cells may enable discrimination between tumors and normal cells.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014343:Trypan Blue / Q000378:metabolism*
D014343:Trypan Blue; D007208:Indocyanine Green