title: Effects of marijuana on testosterone in male subjects.
abstract: Clinical studies have given contradictory reports on the effect of smoking marijuana on the plasma levels of testosterone in males. A reanalysis of existing data established that testosterone levels are depressed both after smoking one marijuana cigarette and after intravenous infusion of delta-9-tetrahydrocannabinol, a pharmacologically active component of marijuana. Simulation of the marijuana interaction, under the assumption that delta-9-tetrahydrocannabinol inhibits testosterone production or secretion, suggests a minimum of 24 hours are required for testosterone to return to pre-smoking levels. A series of clinical studies are specified to clarify the nature of the interaction.
mesh_terms: D002188:Cannabis; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008954:Models, Biological; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D013759:Dronabinol