[Anti-smooth-muscle antibody activity of monoclonal IgM in Waldenström's disease].
The authors report a case of Waldenstrom disease in which the IgM kappa immunoglobulin had an anti-smooth-muscle activity at a very high titre (1/100 000). This activity was found in the purified IgM but not in the Fab fragment; nevertheless, the immunofluorescence inhibition by this fragment is evidence in support of the anti-smooth-muscle activity of the IgM. The IgM specificity in this patient is different from the anti-smooth-muscle antibodies already described.
D000911:Antibodies, Monoclonal / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology*; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology*
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D007075:Immunoglobulin M
Activité anticorps anti-muscle lisse de l'IgM monoclonale au cours d'une maladie de Waldenström.