An Epstein-Barr virus-negative B lymphoma cell line (THP-2) from a Burkitt's lymphoma of a Japanese patient.
An Epstein-Barr virus-negative lymphoma cell line, THP-2, was established from a Burkitt's lymphoma taken from a Japanese patient. THP-2 cells grew in single cell suspension with a doubling time of 24 hr; the cells carried surface-bound mu-lambda immunoglobulins and formed rosettes with IgG antibody-coated ox erythrocytes. THP-2 cells expressed B1, common acute lymphoblastic leukemia (ALL) (J5) and Ia-like antigens of their surface as defined by monoclonal antibodies. Epstein-Barr virus-associated nuclear antigen (EBNA) was not detected. The cell line THP-2 has been maintained for over 5 years. Among the markers examined, only common ALL antigen has been present on the cell surface of THP-2 for these 5 years.
D000956:Antigens, Viral / Q000032:analysis*; D001402:B-Lymphocytes; D002051:Burkitt Lymphoma / Q000276:immunology / Q000382:microbiology / Q000473:pathology*; D002460:Cell Line; D002648:Child; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007564:Japan; D008297:Male
D000956:Antigens, Viral