[Acute lymphoblastic leukemia with major eosinophilia. Inaugural cardiac insufficiency, endocarditis grafting and valve replacement].
Acute lymphoblastic leukemia (cytologically typical) was diagnosed in an 18-year-old man presenting with major eosinophilia. Prednisone therapy was initiated but sudden congestive heart failure occurred (left ventricular insufficiency with pulmonary edema). Concomitantly, blood counts became normal. Remission of the leukemic process was obtained while severe mitral regurgitation developed, due to bacterial endocarditis. Successful mitral valvuloplasty was achieved. Remission is still persisting one year after diagnosis.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000150:complications; D004802:Eosinophilia / Q000150:complications*; D006333:Heart Failure / Q000209:etiology; D006350:Heart Valve Prosthesis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000601:surgery; D008945:Mitral Valve Prolapse / Q000209:etiology / Q000601:surgery
D000970:Antineoplastic Agents
Leucémie aiguë lymphoblastique avec grande éosinophilie. Insuffisance cardiaque inaugurale, greffe endocarditique et remplacement valvulaire.