A multifunctional calmodulin-dependent protein kinase. Similarities between skeletal muscle glycogen synthase kinase and a brain synapsin I kinase.
Calmodulin-dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site-specificities, immunological cross-reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin-dependent protein kinase that mediates many of the actions of Ca2+ in various tissues. Therefore, we propose the name 'calmodulin-dependent multi-protein kinase' for this broad specificity enzyme.
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000201:enzymology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002147:Calmodulin / Q000502:physiology*; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D038341:Glycogen Synthase Kinases; D007120:Immunochemistry; D009132:Muscles / Q000201:enzymology*; D010446:Peptide Fragments; D011494:Protein Kinases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013379:Substrate Specificity
D002147:Calmodulin; D010446:Peptide Fragments; D011494:Protein Kinases; D038341:Glycogen Synthase Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases