The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence.
The intracellular generation of reactive forms of reduced oxygen, namely, hydrogen peroxide, superoxide and hydroxyl radical, can damage dopamine neurons. Oxy-radicals, and hydrogen peroxide generated by monoamine oxidase, can contribute to increased rates of senescence of dopamine neurons in Parkinson's disease. The evidence that oxy-radicals and monoamine oxidase are potentially cytotoxic is reviewed, and a pathobiology of dopamine neuron senescence in Parkinson's disease is proposed.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002374:Catalase / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007980:Levodopa / Q000627:therapeutic use; D008995:Monoamine Oxidase / Q000378:metabolism; D009410:Nerve Degeneration / Q000187:drug effects; D009474:Neurons / Q000201:enzymology; D010300:Parkinson Disease / Q000188:drug therapy / Q000201:enzymology*; D051381:Rats; D012642:Selegiline / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D002395:Catecholamines; D006878:Hydroxides; D013481:Superoxides; D012642:Selegiline; D017665:Hydroxyl Radical; D007980:Levodopa; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase; D004298:Dopamine