Autoradiographic localization of drug and neurotransmitter receptors: focus on the opiate receptor.
Receptors for drugs and neurotransmitter can be visualized at the light microscopic level by autoradiography after "in vitro" labelling of slide-mounted tissue sections. This methodology is illustrated by the localization of mu, delta and kappa opiate receptors in the rat, guinea-pig and human brains using the opiate ligand 3H-(--)-bremazocine. The differential anatomical localizations of these sites and their relationship with opiate effects is discussed.
D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D011817:Rabbits; D051381:Rats; D011955:Receptors, Drug / Q000302:isolation & purification*; D017981:Receptors, Neurotransmitter / Q000302:isolation & purification*; D011957:Receptors, Opioid / Q000302:isolation & purification*; D013045:Species Specificity
D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D011957:Receptors, Opioid