title: Therapeutic effect of optimal lincomycin concentration in drinking water on necrotic enteritis in broilers.
abstract: The efficacy of 16.9 mg lincomycin/liter of drinking water was evaluated for the treatment of necrotic enteritis (NE) in 743 broiler-type chickens. Birds were raised in a facility containing a built-up litter obtained from a source that experienced NE. They were commingled from 1 day of age until NE was observed. Two groups of 6 pens each were given 0 or 16.9 mg lincomycin/liter of drinking water. Water medication was offered fresh daily for 7 days and the study was terminated 3 weeks after initiation of therapy. The susceptibility of Clostridium perfringens to lincomycin was determined in vitro. The test organism was susceptible to lincomycin as reflected by minimal inhibitory concentration and minimal lethal concentration of .156 microgram/ml. Mortality attributed to NE was 0% in lincomycin treated birds and 14% in nonmedicated control birds (P less than .01). Lincomycin water medication was highly effective for the treatment of NE in broilers.
mesh_terms: D000818:Animals; D002645:Chickens; D003015:Clostridium Infections / Q000188:drug therapy / Q000662:veterinary*; D003016:Clostridium perfringens; D004326:Drinking; D004751:Enteritis / Q000188:drug therapy / Q000662:veterinary*; D008034:Lincomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009336:Necrosis; D011201:Poultry Diseases / Q000188:drug therapy*
chemical_list: D008034:Lincomycin