Benzodiazepine receptors in the human fetus.
The existence of benzodiazepine receptors in the human fetal brain, liver and placenta has been studied. At 12-15 weeks of gestation specific binding to fetal brain occurs. The dissociation constant of [3H]-flunitrazepam-specific binding was 1.5-2 nM and the maximum number of binding sites was 2.3-3.8 fmol/mg of total brain tissue. In the fetal liver and placenta some specific binding exists, yet the nonspecific binding is more extensive.
D000328:Adult; D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005445:Flunitrazepam / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D051379:Mice; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis*; D011963:Receptors, GABA-A
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005445:Flunitrazepam