Biphasic actions of pentobarbital on synaptic transmission.
The effects of pentobarbital were studied on synaptic transmission in the rat hippocampal slice preparation. Low concentrations of pentobarbital (0.04 - 0.1 mM) produced an increase in the Schaffer collateral to CA 1 evoked EPSP and population field potential amplitudes. Higher concentrations of pentobarbital (0.2 - 1.0 mM) produced depression of field potential amplitudes. Pentobarbital altered synaptic transmission by affecting both pre- and post-synaptic functions. Analysis of input/output curves suggest the presynaptic site is most sensitive.
D000818:Animals; D046508:Culture Techniques; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D010424:Pentobarbital