Metabolic rate in different rat brain areas during seizures induced by a specific delta opiate receptor agonist.
The glucose utilization during specific delta opiate agonist-induced epileptiform phenomena, determined by the [14C]2-deoxyglucose technique (2-DG), was examined in various rat brain areas at different time intervals. The peak in EEG spiking response and the most intensive 2-DG uptake occurred 5 min after intraventricular (i.v.t.) administration of the delta opiate receptor agonist. The most pronounced 2-DG uptake at this time interval can be observed in the subiculum, including the CA1 hippocampal area, frontal cortex and central amygdala. A general decrease of glucose consumption, compared to control values, is observed after 10 min, in all regions, with exception of the subiculum. Since functional activity and 2-DG uptake are correlated, we suggest that the subiculum and/or CA1 area, are probably the brain regions most involved in the enkephalin-induced epileptic phenomena.
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology / Q000503:physiopathology; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004569:Electroencephalography; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives*; D007700:Kinetics; D008297:Male; D009842:Oligopeptides / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*; D017465:Receptors, Opioid, delta; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology
D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D009842:Oligopeptides; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D004743:Enkephalin, Leucine; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-; D003847:Deoxyglucose