Impaired nerve-muscle interaction by percutaneous terphenyl exposure.
Rat tail muscle responses decreased in amplitude and showed polyphasia in intermittent (3 h daily for 4 to 8 wks) percutaneous exposure to a commercial terphenyl mixture. The gross conduction times did not change excluding demyelination as a mechanism. The exposure technique allowed an exact estimation of the absorbed dose (0.23 +/- 0.05 g/12 cm2 skin in 3 h). This could be altered by changing the skin contact time. The described technique may used also in the detection of local toxicity of other lipid-soluble compounds.
D000818:Animals; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D012867:Skin / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*; D013730:Terphenyl Compounds / Q000008:administration & dosage / Q000633:toxicity*
D013730:Terphenyl Compounds