Exocrine pancreatic function in diabetic rats treated with intraportal islet transplantation.
Streptozotocin-diabetic rats with chronic pancreatic fistula show severe impairment of secretin-stimulated pancreatic secretion while the action of pancreozymin remains unchanged. Intrahepatic transplantation of islets of Langerhans restores the response of ductal cells to secretin; physiological control of insulin secretion appears to be essential for exocrine function.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000601:surgery; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D016381:Islets of Langerhans Transplantation; D008099:Liver / Q000601:surgery*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D012633:Secretin / Q000494:pharmacology; D012844:Sincalide / Q000494:pharmacology
D001639:Bicarbonates; D007328:Insulin; D012633:Secretin; D012844:Sincalide