Differential location of adenosine A1 and A2 receptors in striatum.
Stimulation of either adenosine A1 or A2 receptors results in a decrease or an increase in the adenylate cyclase activity, respectively. With various concentrations of the adenosine agonist N6-phenylisopropyladenosine, both responses on cyclase are observed in a crude membrane preparation from rat striatum. The A2 receptors appeared to be associated primarily with intrinsic striatal neurons, as a kainic acid injection into the striatum resulted in about a 70% loss of receptor responsiveness to cyclase. The A1 receptors were more diffuse, being associated with intrinsic neurons and with cortical-striatal nerve terminals. From studies with 6-hydroxydopamine, we were unable to associate either receptor with dopaminergic nerve terminals within the striatum.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D007608:Kainic Acid / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis*; D011983:Receptors, Purinergic; D014018:Tissue Distribution
D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D010660:Phenylisopropyladenosine; D007608:Kainic Acid