Purine synthesis during amino acid starvation of lymphoblasts with HPRT deficiency or PP-ribose-P synthetase overactivity decreases less than in normal cells.
D000596:Amino Acids / Q000378:metabolism*; D002460:Cell Line; D002478:Cells, Cultured; D003513:Cycloheximide / Q000494:pharmacology; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000172:deficiency*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D011687:Purines / Q000096:biosynthesis*; D012268:Ribose-Phosphate Pyrophosphokinase / Q000378:metabolism*
D000596:Amino Acids; D011687:Purines; D003513:Cycloheximide; D007041:Hypoxanthine Phosphoribosyltransferase; D010770:Phosphotransferases; D012268:Ribose-Phosphate Pyrophosphokinase