Excitatory effect of dehydroepiandrosterone, its sulphate ester and pregnenolone sulphate, applied by iontophoresis and pressure, on single neurones in the septo-preoptic area of the guinea pig.
When dehydroepiandrosterone (D), its ester sulphate (DS) and pregnenolone sulphate (PS) were applied iontophoretically or by pressure to neurones in the septo-preoptic area, an excitatory effect was observed. DS and PS, applied on the same neurone, always produced a similar effect. When DS and D were tested, some neurones were excited by both steroids whereas others responded to DS but were unaffected by D. DS-, PS- and D-induced responses displayed a short latency in onset and offset, suggesting an action at the membrane level as for other steroids.
D000818:Animals; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019314:Dehydroepiandrosterone Sulfate; D005260:Female; D006168:Guinea Pigs; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D011284:Pregnenolone / Q000494:pharmacology*; D011301:Preoptic Area / Q000187:drug effects*; D012688:Septum Pellucidum / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
C018370:pregnenolone sulfate; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D011284:Pregnenolone