[Effect of one-time and chronic administration of ethanol on the concentration of beta-endorphin in the brain of rats with different alcoholic motivation].
The concentration of beta-endorphin was determined in the cortex of the large hemispheres, thalamus, striatum and medulla oblongata of rats with varying duration of ethanol anesthesia and after a single injection of ethanol (2.5 g/kg). The content of beta-endorphin was also measured in the brain of rats which preferred and rejected 15% ethanol during long-term (up to 10 months) alcoholization. The data obtained indicate that ethanol produces a specific effect on the endorphinergic system in different brain structures of animals predisposed to voluntary alcoholization. A possible involvement of the neuropeptide in the formation of alcohol tolerance and physical dependence is discussed.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000523:psychology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D009042:Motivation / Q000502:physiology*; D051381:Rats; D013997:Time Factors; D001615:beta-Endorphin
D004723:Endorphins; D000431:Ethanol; D001615:beta-Endorphin
Vliianie odnokratnogo i khronicheskogo vvedeniia étanola na kontsentratsiiu beta-éndorfina v golovnom mozge krys s razlichnoĭ alkogol'noĭ motivatsieĭ.