Inhibition by loperamide of deoxycholic acid induced intestinal secretion.
The effect of loperamide on deoxycholic acid (DOC)-induced secretion was studied in ligated loops of the rat jejunum and colon in vivo. In controls, loperamide slightly augmented fluid absorption. 3 mmol DOC caused net fluid secretion. Loperamide reduced this secretion in the colon and reversed it to absorption in the jejunum. Na-K-ATPase specific activity and cAMP levels were measured in the jejunum, and [14C]erythritol clearance as an index of mucosal permeability in the colon. In the jejunum this opiate analogue affected neither basal or DOC-depressed Na-K-ATPase, nor mucosal cAMP. In the colon it reduced a large increase of the erythritol clearance caused by DOC. It is suggested that loperamide interferes with DOC-induced intestinal secretion in part by lowering mucosal permeability.
D000818:Animals; D003106:Colon / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D003840:Deoxycholic Acid / Q000037:antagonists & inhibitors*; D004896:Erythritol / Q000378:metabolism; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism*; D007419:Intestinal Secretions / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D008139:Loperamide / Q000494:pharmacology*; D008657:Metabolic Clearance Rate; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D010880:Piperidines; D003840:Deoxycholic Acid; D008139:Loperamide; D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase; D004896:Erythritol