The response of Kenyan kala-azar to treatment with sodium stibogluconate.
Of 16 patients with kala-azar treated with sodium stibogluconate (0.1 ml/kg body weight a day), one died on the 12th day of treatment and nine were cured by a 30-day course, although two subsequently relapsed. Extending the course cured a further five patients, and in one patient allopurinol was used in addition before a cure was achieved. Clinical and hematological recovery began within a few days of the start of treatment, but parasites continued to be seen in splenic aspirates for 3 weeks or more.
D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D004909:Erythrocyte Indices; D005260:Female; D005942:Gluconates / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007630:Kenya; D007891:Leishmania / Q000187:drug effects; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D007958:Leukocyte Count; D008297:Male; D013154:Spleen / Q000469:parasitology
D005942:Gluconates; D006454:Hemoglobins; D000967:Antimony Sodium Gluconate