title: Myxoviruses do not induce non-specific alterations in membrane permeability early on in infection.
abstract: The permeability characteristics of cells infected with myxoviruses have been studied by measuring the concentrative uptake of nutrients, the concentration of intracellular K+, and the maintenance of the Na+ gradient across the plasma membrane. Cells either show no change at all (Sendai virus-infected BHK cells and measles virus-infected Vero cells) or they show a decreased ability to concentrate nutrients, while intracellular K+ and the Na+ gradient remain unchanged (Sendai and influenza virus-infected L-1210 cells, measles virus-infected lymphocytes and mumps virus-infected L-41 cells). In no case, therefore, was a change observed that resembles the non-specific increase in membrane permeability induced by haemolytic paramyxoviruses (35, 42) or the non-specific membrane leakiness postulated to take place in infected cells (8, 9). A preliminary account of some of these findings has been presented (39).
mesh_terms: D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D006801:Humans; D009980:Influenza A virus / Q000502:physiology*; D008214:Lymphocytes / Q000382:microbiology; D008459:Measles virus / Q000502:physiology*; D009109:Mumps virus / Q000502:physiology*; D010222:Parainfluenza Virus 1, Human / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D014176:Protein Biosynthesis; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium; D011188:Potassium; D002118:Calcium