title: Kinetics of phytohemagglutinin response in chickens infected with various strains of Marek's disease virus.
abstract: Phytohemagglutinin (PHA) response of whole blood lymphocytes from white leghorn inbred line 7(2) chickens infected with various strains of Marek's disease virus (MDV) was monitored sequentially for 6 weeks postinfection. A significant difference between JM and GA strains was shown. A two-phase depression in the PHA response was observed in chickens infected with the JM strain. Early depression occurred 1 week postinfection and was followed by recovery a week later. The second depression occurred at 4 weeks postinfection and lasted until the end of the experiment. The GA strain-infected group, on the other hand, began to show depression 4 weeks postinfection, and most chickens died within a short time thereafter. PHA response of chickens infected with strain Md11/75C, attenuated in cell culture from highly virulent strain Md11, was almost the same as that of control chickens.
mesh_terms: D000818:Animals; D002645:Chickens / Q000276:immunology; D008381:Herpesvirus 2, Gallid / Q000472:pathogenicity*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects; D008380:Marek Disease / Q000276:immunology* / Q000382:microbiology; D010835:Phytohemagglutinins / Q000494:pharmacology; D014774:Virulence
chemical_list: D010835:Phytohemagglutinins