Enhanced susceptibility of a transposable-element-bearing strain of Drosophila melanogaster to somatic eye-color mutations by ethyl nitrosourea, methyl nitrosourea, and X-rays.
A strain of Drosophila with the genes z and w+ plus a transposable element (TE) is about 3 times more sensitive than a strain without TE toward somatic eye-color mutations after larval exposure to ethyl nitrosourea, methyl nitrosourea and X-rays. The assay system with TE is simple, reliable, and sensitive for detecting somatic mutations induced in vivo by mutagens.
D000818:Animals; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics*; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects / Q000528:radiation effects; D009607:Nitrosourea Compounds / Q000633:toxicity; D012168:Retinal Pigments / Q000235:genetics; D014965:X-Rays
D004251:DNA Transposable Elements; D009607:Nitrosourea Compounds; D012168:Retinal Pigments