title: A bovine virus diarrhea calfhood vaccination trial in a persistently infected herd: effects on titres, health and growth.
abstract: A controlled calfhood vaccination trial to prevent bovine virus diarrhea was conducted in a 100 head cow-calf operation with a three year history of annual calf losses due to enteric bovine virus diarrhea (persistently infected herd). Approximately 50% of the calves were vaccinated at six, 12 and 24 weeks of age. Paired serum samples and growth data were collected on three occasions for comparison between vaccinates and controls. Three vaccinated calves died of enteric bovine virus diarrhea in the first year of the trial and one nonvaccinated calf died in the second year. Two of the three vaccinated calves had developed bovine virus diarrhea virus neutralization antibody titres of 2048 or greater before developing clinical signs. The control and third vaccinated calf failed to seroconvert before dying of enteric bovine virus diarrhea. Approximately 90% of the vaccinated calves seroconverted compared to approximately 40% of the controls. Paired serum samples collected from 75% of the cows in the spring, summer and fall of each year of the trial, showed persistent high bovine virus diarrhea virus neutralization titres in all samples. Calf vaccination before 12 weeks of age had little effect on seroconversion due to high levels of passive antibody to bovine virus diarrhea. Growth data showed that there was no improvement in weight gain or rate of growth in the vaccinated calves.
mesh_terms: D000367:Age Factors; D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development; D000914:Antibodies, Viral / Q000032:analysis*; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000150:complications / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology*; D005260:Female; D008297:Male; D010576:Pestivirus / Q000276:immunology*; D014412:Tumor Virus Infections / Q000150:complications / Q000662:veterinary; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines