Binding of adult T-cell leukemia virus to various hematopoietic cells.
A newly found human retrovirus, adult T-cell leukemia virus (ATLV) was shown by means of membrane immunofluorescence to bind to various hematopoietic cells including T-, B- and non-T, non-B-cell lines. Partially purified viral gp46 from culture fluids of ATL virus producer lines also bound efficiently to an ATLV-negative T-cell line, CCRF-CEM cells. When the viruses were pre-incubated with anti-ATLV-positive human sera, ATLV binding to the cells was clearly inhibited but not by pre-incubation with anti-ATLV-negative sera. These data suggest that: (1) ATLV binds not only to T-cells but also to multiple types of cells of hematopoietic origin; (2) anti-ATLV antibody-positive human sera have the blocking antibody for the binding of ATLV to lymphoid cells.
D000951:Antigens, Neoplasm / Q000032:analysis; D002460:Cell Line; D017977:Deltaretrovirus / Q000472:pathogenicity*; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000502:physiology; D006413:Hematopoietic System / Q000382:microbiology*; D006801:Humans; D011991:Receptors, Virus / Q000032:analysis*; D014764:Viral Proteins / Q000502:physiology
D000951:Antigens, Neoplasm; D006023:Glycoproteins; D011991:Receptors, Virus; D014764:Viral Proteins