Isolation and analysis of inhibitors of transposon Tn3 site-specific recombination.
We have constructed a genetic bioassay for inhibitors of site-specific recombination by transposon Tn3 resolvase. Of 6,000 compounds tested, 26 inhibited in vivo, and 5 of these 26 inhibited in vitro. At least two inhibitors also inhibit the topoisomerase of resolvase. We have also identified analogs of A1062 which inhibit.
D004251:DNA Transposable Elements / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D005796:Genes; D005798:Genes, Bacterial; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D011995:Recombination, Genetic / Q000187:drug effects; D013329:Structure-Activity Relationship; D019895:Transposases
D004251:DNA Transposable Elements; D004791:Enzyme Inhibitors; D009713:Nucleotidyltransferases; D019895:Transposases