Direct action of pertussis toxin in isolated hamster fat cells.
Incubation of pieces of adipose tissue in the presence of pertussis toxin (10-100 micrograms/ml) resulted in blockade in the isolated fat cells of the action of agents that inhibit adenylate cyclase through receptor-mediated GTP-dependent processes (alpha 2-adrenergic amines, prostaglandins, Ri-adenosine, nicotinic acid) and enhancement of the action of isoproterenol. There was a lag period of approximately 2 h for the action of the toxin.
D037361:Adenylate Cyclase Toxin; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D006224:Cricetinae; D000242:Cyclic AMP / Q000378:metabolism*; D019204:GTP-Binding Proteins; D008297:Male; D008647:Mesocricetus; D037342:Pertussis Toxin; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors; D010566:Virulence Factors, Bordetella
D037361:Adenylate Cyclase Toxin; D001427:Bacterial Toxins; D011956:Receptors, Cell Surface; D010566:Virulence Factors, Bordetella; D000242:Cyclic AMP; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins