[Structural and kinetic parameters of the oxidative phosphorylation system, participating in the synchronization of mitochondrial respiratory chain and ATP-synthetase functions].
The structural and kinetic parameters of the oxidative phosphorylation system responsible for synchronization of the respiratory chain and ATP-synthetase function in mitochondria were studied. It was shown that regulation of ATP-synthetase function by the respiratory chain can be realized only within the whole ATP-synthetase complex (F0F1). NADH dehydrogenase and succinate dehydrogenase doe not control synchronization of ATP-synthetase function in the mitochondria. Data from the inhibitory analysis suggest that the ATP-synthetase function depends on the rate of the enzyme operation but not on the redox state of the respiratory chain carriers.
D025181:ATP Synthetase Complexes; D000818:Animals; D002417:Cattle; D004579:Electron Transport; D007700:Kinetics; D008929:Mitochondria, Heart / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000378:metabolism*; D009245:NADH Dehydrogenase / Q000378:metabolism; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D009097:Multienzyme Complexes; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D010770:Phosphotransferases; D025181:ATP Synthetase Complexes
Poisk strukturnykh i kineticheskikh parametrov sistemy okislitel'nogo fosforilirovaniia, uchastvuiushchikh v sinkhronizatsii raboty dykhatel'noĭ tsepi i ATP-sintetazy mitokhondriĭ.