title: Induction of surface IgG receptors in cytomegalovirus-infected human fibroblasts.
abstract: Binding studies on diploid human fibroblasts with human immunoglobulin G (IgG) demonstrate the existence of a specific receptor for this class of immunoglobulin. The receptor preferentially binds aggregated human IgG and recognizes these complexes via the Fc portion of the molecule. Cytomegalovirus infection of diploid human fibroblasts results in a more than 100-fold increase in the number of IgG-receptors present on the cell surface. The binding of aggregated IgG by these newly expressed receptors exhibits the characteristics of the binding mediated by the receptors detectable in uninfected cells.
mesh_terms: D001667:Binding, Competitive; D055598:Chemical Phenomena; D002621:Chemistry; D003587:Cytomegalovirus; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000378:metabolism; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism; D066298:In Vitro Techniques; D017452:Receptors, IgG; D011971:Receptors, Immunologic / Q000378:metabolism*
chemical_list: D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D017452:Receptors, IgG; D011971:Receptors, Immunologic