title: [Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis].
abstract: This comparative trial, in which each patient acts as his own control, is an ideal model for comparing the effectiveness of both products. None of the criteria studied demonstrated a statistically significant difference in effectiveness between the two agents. Under the conditions of this study, Bi-Profenid and indomethacin can therefore be considered as having comparable potency. Study of tolerance demonstrated a superiority of Bi-Profenid over indomethacin, with excellent results in 72.5% and 66.1% of cases respectively. Specifically, digestive and above all neuro-sensory tolerance was better with Bi-Profenid. Osteoarthritis is a good indication for these medications whose effectiveness is well documented.
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006621:Hip Joint; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy; D010666:Phenylpropionates / Q000627:therapeutic use*; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D010666:Phenylpropionates; D013607:Tablets; D007660:Ketoprofen; D007213:Indomethacin
vernacular_title: Etude comparative à double insu du kétoprofène comprimés à libération prolongée et de l'indométacine dans la coxarthrose et la gonarthrose.