title: Laboratory and clinical studies on the mechanism of action of timolol.
abstract: Timolol is now widely used in the treatment of glaucoma but its mechanism of action is unclear. The drug decreases aqueous humor formation by the ciliary processes and is a potent beta-adrenergic antagonist. However, the physiological basis for such a drug to decrease intraocular pressure has not been clearly demonstrated.
mesh_terms: D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects; D002415:Cats; D002924:Ciliary Body / Q000187:drug effects; D000242:Cyclic AMP / Q000096:biosynthesis; D006801:Humans; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013999:Timolol / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D011943:Receptors, Adrenergic, beta; D013999:Timolol; D000242:Cyclic AMP