Expression of HLA-DR antigens at the surface of mouse L cells co-transfected with cloned human genes.
The H-2 I region in the mouse and the HLA-D region in humans contain a set of polymorphic genes which encode Ia antigens and control the immune response. Cloned genes for the different polypeptide chains of one of the human Ia antigens, HLA-DR, have been used for the co-transformation of mouse L cells. Expression of HLA-DR antigens at the surface of transfected mouse cells has been documented with monoclonal antibodies.
D000818:Animals; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D005455:Fluorescent Antibody Technique; D005796:Genes; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens; D006801:Humans; D007739:L Cells / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D009154:Mutation; D009693:Nucleic Acid Hybridization; D013937:Thymidine Kinase / Q000172:deficiency; D014162:Transfection
D006684:HLA-DR Antigens; D013937:Thymidine Kinase; D004262:DNA Restriction Enzymes