Ribosomal resistance of clinical enterococcal to streptomycin isolates.
The mechanism of high-level resistance to streptomycin was studied in 12 clinical isolates of Streptococcus faecalis. Six strains produced streptomycin-modifying enzymes. Each of three enzyme-negative strains tested demonstrated ribosomal resistance to streptomycin. Lack of ribosomal susceptibility is a significant cause of high-level streptomycin resistance among clinical enterococcal isolates.
D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D007612:Kanamycin / Q000494:pharmacology; D009713:Nucleotidyltransferases / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects*; D013290:Streptococcal Infections / Q000382:microbiology; D013307:Streptomycin / Q000494:pharmacology*
D010649:Phenylalanine; D007612:Kanamycin; D009713:Nucleotidyltransferases; C022678:streptomycin 3''-adenylyltransferase; D013307:Streptomycin