Duodenal somatostatinoma. Immunohistopathology and review of literature.
A case of duodenal somatostatinoma is reported. The patient, a 54-year-old male, had complained of an epigastric pain due to gastric ulcer and a duodenal polyp was unexpectedly found at a gastrectomy. The polyp showed basically tubular adenocarcinoma, with negative argyrophil and argentaffin reactions. By an indirect immunofluorescent examination almost all of the tumor cells were revealed as somatostatin-immunoreactive. Big somatostatin was also positive. Radioimmunoassay of the tumor indicated 6400 pg of somatostatin-like immunoreactivity per milligram of wet tissue. This seems to be the second case of duodenal somatostatinoma, following the case reported by us previously.
D007516:Adenoma, Islet Cell / Q000276:immunology*; D004379:Duodenal Neoplasms / Q000276:immunology* / Q000601:surgery / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006801:Humans; D007118:Immunoassay; D007417:Intestinal Polyps / Q000276:immunology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D013005:Somatostatinoma / Q000276:immunology* / Q000601:surgery / Q000648:ultrastructure