[Analysis of the effect of cholecystokinin octapeptide on the monoamine level in rat brain limbic structures in the process of satiation].
The authors studied the changes in monoamine levels in rat brain limbic structures during natural satiation and satiation after intraperitoneal injection of cholecystokinin octapeptide (CCK-8) in doses 5 and 10 micrograms/kg following 24- and 48-hour food deprivation. Injection of CCK-8 was found to reduce food consumption in hungry rats by 2.5 times on an average. Of the test animals, 25% appeared resistant to CCK-8, showing no reduction in food consumption. Satiation after the 24-hour food deprivation caused characteristic changes in the levels of noradrenaline, dopamine and serotonin in the limbic structures of the brain, similar to the changes in monoamine levels in the limbic structures of animals, in which food motivation was suppressed by injection of CCK-8. The responses of the monoaminergic system of the brain limbic structures to satiation induced by CCK-8 injection after the 48-hour food deprivation differed qualitatively from the responses to natural satiation. It is concluded that the inhibitory action of CCK-8 on food motivation in rats determined by the 24-hour fasting is likely to be mediated via the monoamine system of the hypothalamus, tonsils and hippocamp. However, the data obtained suggest a different mechanism of the satiating action of CCK-8 under marked food motivation after long-term periods of food deprivation.
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D012527:Satiation / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D012844:Sincalide / Q000494:pharmacology*
D012701:Serotonin; D012844:Sincalide; D004298:Dopamine; D009638:Norepinephrine
Analiz vliianiia oktapeptida kholetsistokinina na uroven' monoaminov limbicheskikh struktur mozge v protsesse nasyshcheniia.