[Disulfide reductase activity in mouse regenerating liver].
Fourteen hours after partial hepatectomy there was a decrease in basal disulfide reductase and glutathione reductase activity in cytosole fraction of proliferating hepatocytes. In nuclear fraction, the activation effect of cAMP and cGMP on the disulfide recovery was replaced by inhibition. Meanwhile the activity of glutathione reductase noticeably increased. Forty-five hours after operation disulfide reductase activity of cytosole appreciably rose during maximal mitotic activity of the regenerating liver. The data obtained provide evidence in favor of the involvement of disulfide reductase enzymes into reparative regeneration of the liver.
D000818:Animals; D002467:Cell Nucleus / Q000201:enzymology; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D003600:Cytosol / Q000201:enzymology; D004789:Enzyme Activation; D005260:Female; D005980:Glutathione Reductase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D010088:Oxidoreductases / Q000378:metabolism*; D011490:Protein Disulfide Reductase (Glutathione) / Q000378:metabolism*
D000242:Cyclic AMP; D010088:Oxidoreductases; D005980:Glutathione Reductase; D011490:Protein Disulfide Reductase (Glutathione); D006152:Cyclic GMP
Aktivnost' disul'fidreduktaznykh fermentov regeneriruiushcheĭ pecheni mysheĭ.