Cellulase biosynthesis in a catabolite repression-resistant mutant of Thermomonospora curvata.
A catabolite repression-resistant mutant of the thermophilic actinomycete Thermomonospora curvata was obtained by treatment with ethyl methanesulfonate and UV light. Cellulase biosynthesis was undiminished by glucose, 2-deoxyglucose, or alpha-methyl glucoside, which are potent repressors in the wild type. Intracellular cyclic AMP levels were higher in the mutant in both the absence and the presence of repressors.
D002480:Cellulase / Q000096:biosynthesis*; D000242:Cyclic AMP / Q000032:analysis; D004794:Enzyme Repression; D005947:Glucose / Q000494:pharmacology; D008848:Micromonosporaceae / Q000201:enzymology* / Q000235:genetics; D009154:Mutation
D000242:Cyclic AMP; D002480:Cellulase; D005947:Glucose