title: [Combined, local and chemical protection of the body against radiation exposure during space flight].
abstract: This paper summarizes studies of the combined protection of dogs exposed to acute high energy proton irradiation at a dose of 400 rad. The chemical radioprotector--mexamine--was injected intramuscularly at a dose of 10 mg/kg or administered per os at a dose of 75 mg/kg. During the exposure 14.5% of bone marrow was shielded. The dose behind the shielding was 250 rad. The combined use of mexamine administered per os and partial bone marrow shielding provided better protection, whereas either type of protection applied separately proved inefficient.
mesh_terms: D008735:5-Methoxytryptamine / Q000008:administration & dosage; D000818:Animals; D004285:Dogs; D005260:Female; D007958:Leukocyte Count; D008297:Male; D011522:Protons; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000453:epidemiology / Q000401:mortality; D011835:Radiation Protection / Q000295:instrumentation / Q000379:methods*; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D013026:Space Flight / Q000295:instrumentation; D013997:Time Factors
chemical_list: D011522:Protons; D011837:Radiation-Protective Agents; D008735:5-Methoxytryptamine
vernacular_title: Kombinirovannaia, lokal'naia i khimicheskaia zashchita organizma ot radiatsionnogo vozdeĭstviia pri kosmicheskikh poletakh.