Pavlovian drug-sickness pairings result in the conditioning of an antisickness response.
After a drug conditioned stimulus (CS) has been injected prior to lithium chloride as the unconditioned stimulus (US) on five occasions, the drug CS becomes able to evoke a conditioned antisickness response (CAR). This CAR is implied by the finding that the CS drug mitigates the conditioned saccharin aversion produced by lithium when it is administered in the interval between saccharin consumption and lithium injection. The following drugs were tested and are listed in approximate order of their effectiveness in producing a conditioned antisickness effect: pentobarbital, ethanol, morphine, amphetamine, and chlordiazepoxide.
D000818:Animals; D001362:Avoidance Learning; D002712:Chlorides; D003214:Conditioning, Classical; D003463:Cues; D004194:Disease / Q000523:psychology*; D008094:Lithium; D018021:Lithium Chloride; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin; D013649:Taste
D002712:Chlorides; D011619:Psychotropic Drugs; D008094:Lithium; D012439:Saccharin; D018021:Lithium Chloride