Replication of diabetogenic and nondiabetogenic variants of encephalomyocarditis (EMC) virus in ICR Swiss mice.
The replication of the diabetogenic D (EMC-D) and nondiabetogenic B (EMC-B) variants of encephalomyocarditis virus in various tissues of the murine host was determined. Pancreatic insulin levels were also measured. EMC-D replicated in the spleen, pancreas, heart, lung, and intestines, while EMC-B was limited to the spleen and pancreas. EMC-B interfered with the replication of EMC-D in each of the tissues examined. Insulin levels were initially increased by both viruses. By 4 days postinfection, insulin levels were either normal or undetectable in (EMC-D)-infected animals, but were dramatically elevated in those infected with EMC-B.
D000818:Animals; D004261:DNA Replication; D003921:Diabetes Mellitus, Experimental / Q000382:microbiology*; D004686:Encephalomyocarditis virus / Q000235:genetics* / Q000472:pathogenicity; D014644:Genetic Variation; D005951:Glucose Tolerance Test; D007328:Insulin / Q000032:analysis; D007515:Islets of Langerhans / Q000032:analysis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014779:Virus Replication
D007328:Insulin