Alteration of c-myc chromatin structure by avian leukosis virus integration.
The most common sites of integration of the leukosis virus (ALV) long terminal repeat (LTR) in bursal lymphomas and derivative cell lines correspond to a region encompassed by two major hypersensitive sites in the 5' flanking region of the pre-integration, unrearranged c-myc gene. After integration of the ALV LTR, the major hypersensitive site within the avian c-myc oncogene region is within the proviral LTR, and the major hypersensitive sites normally found in uninfected cells 5' to the first c-myc coding exon are no longer detectable.
D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D002460:Cell Line; D002843:Chromatin / Q000648:ultrastructure*; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics; D003851:Deoxyribonucleases; D005786:Gene Expression Regulation; D005796:Genes; D009857:Oncogenes; D011995:Recombination, Genetic
D002843:Chromatin; D004279:DNA, Viral; D003851:Deoxyribonucleases; D004262:DNA Restriction Enzymes