title: Granular cell tumor arising in myelinated peripheral nerves. Light and electron microscopy and immunoperoxidase study.
abstract: The histologic, immunohistochemical and ultrastructural characteristics of two granular cell tumors arising from the right recurrent laryngeal and left facial nerves are described. S-100 protein was detected both in the nuclei and cytoplasm of the granular cells using the peroxidase-anti-peroxidase method. The ultrastructural findings in both cases support a Schwann cell derivation of the granular cells. It is suggested that the granularity of cells of granular cell tumor may represent a lysosomal disorder affecting most frequently neoplastic and nonneoplastic Schwann cells and occasionally other cells.
mesh_terms: D002648:Child; D005154:Facial Nerve; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007823:Laryngeal Nerves; D008854:Microscopy, Electron; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000032:analysis / Q000648:ultrastructure*; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D009418:S100 Proteins / Q000032:analysis; D012583:Schwann Cells / Q000648:ultrastructure
chemical_list: D009418:S100 Proteins