Covalent binding of cefotaxime to human serum albumin.
The covalent binding ratio of cephalosporins (CEZ, CER, CET and CTX) to human serum albumin was examined at pH 7 and pH 10. The antibiotic equivalents were larger at pH 10 than at pH 7. The degree in the binding ratio of the 4 cephalosporins was CET greater than CER greater than CTX greater than CEZ at pH 7 and CER greater than CET greater than CTX greater than CEZ at pH 10.
D000596:Amino Acids / Q000032:analysis; D002437:Cefazolin / Q000097:blood; D002439:Cefotaxime / Q000097:blood*; D002509:Cephaloridine / Q000097:blood; D002512:Cephalothin / Q000097:blood; D006801:Humans; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
D000596:Amino Acids; D012709:Serum Albumin; D002437:Cefazolin; D002509:Cephaloridine; D002439:Cefotaxime; D002512:Cephalothin