[Carney's triad].
The triad described by J.A. Carney in 1977 is characterized by the successive or concomitant occurrence of three rare tumours of different origin: gastric leiomyoblastoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. It is found mainly in young female patients with prevalent blood group A and may be incomplete, with only two of the three tumours occurring. The case of a young woman who developed gastric leiomyoblastoma and, six years later, pelvic paraganglioma is reported; she died of metastases from the paraganglioma with malignant hypertension. The 16 cases already published are reviewed. The authors insist upon the severity of paragangliomas and the need for a systematic search for the other tumours in patients who present with one tumour of the triad. A histogenetic interpretation relating the tumours to pathology of the neural crest is suggested.
D000328:Adult; D002812:Chondroma / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis* / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D010236:Paraganglioma, Extra-Adrenal / Q000175:diagnosis* / Q000473:pathology; D010386:Pelvic Neoplasms / Q000175:diagnosis*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013577:Syndrome
La triade de Carney.