Effect of ouabain on volume regulation of rabbit kidney cortex slices in hypo-osmotic media.
The volume regulation process at work in rabbit kidney cortex slices submitted to hypo-osmotic media show both a swelling limitation and a volume readjustment phase. Swelling limitation is Na+ dependent and is blocked by ouabain 10(-3) M. There is, however, no need to implicate the activity of a ouabain sensitive Na+ /K+ pump in this process.
D000818:Animals; D007038:Hypotonic Solutions; D007473:Ion Channels / Q000502:physiology; D007672:Kidney Cortex / Q000502:physiology*; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D007038:Hypotonic Solutions; D007473:Ion Channels; D012965:Sodium Chloride; D010042:Ouabain; D012964:Sodium; D011188:Potassium