title: Microsomal monooxygenase system in frog livers.
abstract: Liver microsomes prepared from four species of frog, Rana catesbeiana, Rana nigromaculata , Bufo bufo japonicus, and Xenopus laevis, contained cytochrome P-450 and showed NAD(P)H-dependent monooxygenase activities to several foreign chemical compounds tested. The oxidations of the chemical compounds by frog liver microsomes showed significant variations among frog species. The oxidation of 7-ethoxycoumarin was much faster than that by rat liver microsomes. The oxidation of benzo(a)pyrene was significantly induced by 3-methylcholanthrene administration. The monooxygenase activities of frog liver microsomes were more sensitive to cyanide inhibition than those of rat liver microsomes.
mesh_terms: D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism; D002025:Bufonidae; D003374:Coumarins / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D008862:Microsomes, Liver / Q000201:enzymology*; D009243:NAD / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010084:Oxidation-Reduction; D011190:Potassium Cyanide / Q000494:pharmacology; D011892:Rana catesbeiana; D011898:Ranidae; D051381:Rats; D014982:Xenopus laevis
chemical_list: D000814:Aniline Compounds; D001580:Benzopyrenes; D003374:Coumarins; D003573:Cytochrome b Group; D000632:Aminopyrine; D009243:NAD; C017299:7-ethoxycoumarin; D001564:Benzo(a)pyrene; D009249:NADP; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D009247:NADH, NADPH Oxidoreductases; D009251:NADPH-Ferrihemoprotein Reductase; D011190:Potassium Cyanide; C023650:aniline