[Importance of catecholamines and various subtypes of beta-adrenoreceptors for resistance of mice to acute, intensive cooling].
A phase dynamics in body temperature and thermoproduction was shown in the course of cooling of mice. 3 periods of various intensity were noted in thermocompensatory reactions. Within the first period content of noradrenaline was maintained in the vitally important tissues (brain, heart and brown adipose tissues); later on the content of noradrenaline was distinctly decreased. The blockade of ganglions and beta-adrenoreceptors inhibited markedly the thermoproduction and resistance to cooling. The main thermocompensatory reactions were realized via beta 1-adrenoreceptors; blocking of beta 1-adrenoreceptors by means of practolol was more effective as compared with the influence of N-isopropylmethoxamine--inhibitor of beta 2-adrenoreceptors. Importance of beta 1-adrenoreceptors in thermoregulation is discussed.
D000064:Acclimatization; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D002395:Catecholamines / Q000502:physiology*; D003080:Cold Temperature; D005260:Female; D008297:Male; D008729:Methoxamine / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D011217:Practolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta; C038941:isopropylmethoxamine; D008729:Methoxamine; D011217:Practolol
Znachenie katekholaminov i razlichnykh podtipov beta-adrenoretseptorov dlia ustoĭchivosti mysheĭ k ostromu intensivnomu okhlazhdeniiu.