title: Evidence for serotypic variation among bovine rotaviruses.
abstract: Eight field strains of calf rotavirus from the U.K. were compared by neutralisation tests, using convalescent and hyperimmune antisera. Seven of these strains cross-reacted and were considered to be of one serotype, while the 8th was distinguished by a greater than 20-fold two-way difference in neutralisation titre suggesting a second serotype. Three widely-distributed reference strains (U.K., Northern Ireland and Lincoln) cross-reacted with the strains in the dominant serotype, as did 33 of 42 other field calf rotavirus strains. Nine field strains failed to cross-react with either serotype, suggesting the existence of other potential serotypes in the calf population.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D002417:Cattle / Q000382:microbiology*; D002460:Cell Line; D003429:Cross Reactions; D003588:Cytopathogenic Effect, Viral; D005243:Feces / Q000382:microbiology; D005856:Germ-Free Life; D009500:Neutralization Tests; D012330:RNA, Double-Stranded / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D012401:Rotavirus / Q000145:classification* / Q000276:immunology / Q000502:physiology; D012703:Serotyping; D012756:Sheep; D006113:United Kingdom
chemical_list: D000956:Antigens, Viral; D012330:RNA, Double-Stranded; D012367:RNA, Viral