Light microscopic autoradiographic visualization of [3H]-arginine vasopressin binding sites in rat brain.
Specific [3H]-arginine vasopressin ([3H]-AVP) binding sites were identified in the rat brain by light microscopic autoradiography. Discrete intrahypothalamic nuclei were densely labelled by [3H]-AVP. High specific binding was observed in the paraventricular and supraoptic nuclei. These binding sites may represent specific receptors for AVP, postulated to exist in the mammalian central nervous system.
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017483:Receptors, Vasopressin; D013495:Supraoptic Nucleus / Q000378:metabolism; D014018:Tissue Distribution; D014316:Tritium
D011956:Receptors, Cell Surface; D017483:Receptors, Vasopressin; D014316:Tritium; D001127:Arginine Vasopressin