Butyrate reversibly arrests the proliferation of normal and Rous sarcoma virus-infected chicken heart mesenchymal cells.
Sodium butyrate at 5 X 10(-3) M reversibly arrests the proliferation of both normal and RSV-infected chicken heart mesenchymal cells. This finding suggests that butyrate acts by causing non-specific inhibition of cell proliferation, rather then by specifically suppressing the neoplastic phenotype or by inducing recovery of cells from the neoplastic state.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000378:metabolism; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002645:Chickens; D006321:Heart / Q000187:drug effects*; D006338:Heart Neoplasms / Q000378:metabolism*; D009206:Myocardium / Q000166:cytology*; D009374:Neoplasms, Experimental / Q000378:metabolism; D001357:Sarcoma, Avian / Q000378:metabolism*
D002087:Butyrates; D020148:Butyric Acid