Effects of a concentrated bran fibre preparation on HDL-cholesterol in hypercholesterolaemic men.
The effect of adding a purified form of wheat fibre (10.5 g/d) to a lipid-lowering diet was investigated in a placebo-controlled, double-blind, cross-over study (two 8-week periods) in 12 males (36-46 years old) with hypercholesterolaemia. Normolipidaemic men (n = 14, 45-46 years old) were used as controls in evaluation of the seasonal variation of serum lipids and lipoproteins in untreated subjects. Addition of wheat fibre was associated with non-significant decreases in cholesterol in very low and low density lipoproteins and a significant increase in cholesterol in high density lipoprotein. Serum cholesterol was unchanged in the treatment group but increased in the untreated control group. It is concluded that enrichment of a lipid-lowering diet with concentrated wheat fibre may be of value in the treatment of hypercholesterolaemia.
D000328:Adult; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D004043:Dietary Fiber / Q000008:administration & dosage*; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy / Q000378:metabolism*; D008074:Lipoproteins / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008076:Cholesterol, HDL; D004043:Dietary Fiber; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D002784:Cholesterol