[Hormonal regulation of membrane calcium channels in the heart].
It has been shown on the trabecules of frog auricle by potential recording, that prostaglandin E1 (PGE1) increases the number of working calcium channels of the membrane. PGE1, PGE2, acetylcholine, indometacin--inhibitor of PG synthesis and aminazine 2--calmodulin inhibitor do not decrease novodrin--induced intensification of calcium current. The results suggest that a change of cAMP level inside the cell modulates the number of working calcium channels. PG and calmodulin are not necessary for novodrin--stimulation of adenylatcyclase (AC). The effect of acetylcholine is not connected with AC inhibition.
D000109:Acetylcholine / Q000494:pharmacology; D000527:Alprostadil; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D015232:Dinoprostone; D007213:Indomethacin / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D011895:Rana ridibunda
D002147:Calmodulin; D007473:Ion Channels; D011458:Prostaglandins E; D000242:Cyclic AMP; D000527:Alprostadil; D015232:Dinoprostone; D000109:Acetylcholine; D002118:Calcium; D007213:Indomethacin
Gormonal'naia reguliatsiia kal'tsievykh kanalov membrany v serdtse.