title: [Considerations on familial clustering of liver cirrhosis and hepatocellular carcinoma].
abstract: It has been shown here that familial occurrences of liver cirrhosis and hepatocellular carcinoma (HCC) are frequent in Japan. The observations have suggested that, in those families, hepatitis B virus (HBV) infections occurred frequently among the family members, mainly from mother to infant, and that many of the infected persons became HBV carriers; subsequently, some of them developed chronic hepatitis, liver cirrhosis and eventual HCC in their adults. In such pedigrees, susceptibilities to cirrhosis, and also to HCC may be inherited in addition to successive transmission of HBV.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology / Q000635:transmission; D006511:Hepatitis B Antigens / Q000032:analysis; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000235:genetics*; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D013029:Space-Time Clustering
chemical_list: D006511:Hepatitis B Antigens