TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes reduction in the low density lipoprotein (LDL) receptor activities in the hepatic plasma membrane of the guinea pig and rat.
Administration of 1 micrograms/kg (single intraperitoneal injection and studied after 10 days) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to young male guinea pigs was found to cause a significant reduction in binding of low-density lipoprotein (LDL) to its receptor on the hepatic plasma membrane. This reduction in LDL binding is not caused by the decrease of food intake by treated animals since pair-fed control animals had significantly higher LDL binding than treated animals. It was also found that primary hepatocytes from treated animals had a reduced ability to internalize LDL than controls. Such a change in the plasma membrane function may explain the resulting hyperlipidemia particularly hypercholesterolemia which occurs in this species as a result of TCDD administration.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003634:DDT / Q000494:pharmacology; D004147:Dioxins / Q000494:pharmacology*; D006168:Guinea Pigs; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D011973:Receptors, LDL; D013045:Species Specificity
D004147:Dioxins; D008077:Lipoproteins, LDL; D000072317:Polychlorinated Dibenzodioxins; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; D003634:DDT