[Pathogenicity of various toxinogenic types of Clostridium perfringens administered by mouth to axenic and holoxenic mice].
Axenic mice died with signs of enterotoxaemia after oral ingestion of Clostridium perfringens type C or D. Under the same conditions, C. perfringens type B was less pathogenic, and types A and E showed no pathogenicity. The microflora of conventional mice prevented the establishment of C. perfringens types B, C and D in the digestive tract and protected them against the pathogenicity of these strains. Toxins produced in the caecum of monoxenic mice harbouring C. perfringens type C were not neutralized by the anti-C. perfringens type C antiserum. This suggests that the toxins produced in vivo by this strain were different from those produced in vitro.
D000284:Administration, Oral; D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis; D002432:Cecum / Q000382:microbiology; D003016:Clostridium perfringens / Q000378:metabolism / Q000472:pathogenicity*; D005243:Feces / Q000382:microbiology; D005856:Germ-Free Life; D051379:Mice; D008809:Mice, Inbred C3H
D001427:Bacterial Toxins
Pouvoir pathogène de différents types toxinogènes de Clostridium perfringens inoculés per os à des souris axéniques et holoxéniques.