Na+/K+ ATPase and cell growth IV: a metabolic marker of human brain tumors?
The activity of total, Mg++ dependent and Na+/K+ ATPase as well as the content of cAMP and cGMP in homogenates of human brain tumors have been investigated. Results are compared to values obtained from normal cortices. Na+/K+ ATPase and cAMP are decreased with a close relationship with the degree of malignancy, while Mg++ dependent activity is lower than in normal cortex but with no differences between the various tumors, and cGMP is unaffected. We conclude with a discussion on the metabolism of brain tumors and the suggestion of Na+/K+ ATPase activity as a marker of the malignancy of neoplastic growth.
D001254:Astrocytoma / Q000032:analysis / Q000201:enzymology*; D001932:Brain Neoplasms / Q000032:analysis / Q000201:enzymology*; D002528:Cerebellar Neoplasms / Q000201:enzymology; D002551:Cerebral Ventricle Neoplasms / Q000201:enzymology; D000242:Cyclic AMP / Q000032:analysis; D006152:Cyclic GMP / Q000032:analysis; D006801:Humans; D009837:Oligodendroglioma / Q000032:analysis / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase; D006152:Cyclic GMP