Immunoperoxidase demonstration of a new muscle protein (Z-protein) in myogenic tumors as a diagnostic aid.
Z-protein, a new muscle protein with a molecular weight of 55,000 daltons recently discovered in Japan, is an excellent marker for muscle differentiation in paraffin sections. Positive staining by a peroxidase-antiperoxidase technique for detection of intracellular Z-protein was observed in 2 of 2 cardiac rhabdomyomas, 5 of 5 leiomyomas, 9 of 10 leiomyosarcomas, and in 15 of 18 rhabdomyosarcomas including 5 of 5 of the pleomorphic type, 7 of 9 of the embryonal type, and 3 of 4 of the alveolar type. Other types of tumors (77 cases) that sometimes mimic myogenic tumors on histologic examination gave negative results. The immunoperoxidase method for detection of intracellular Z-protein is of use in distinguishing myogenic tumors from other types of tumors.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002352:Carrier Proteins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D050556:Fatty Acid-Binding Proteins; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D007889:Leiomyoma / Q000175:diagnosis / Q000378:metabolism; D008223:Lymphoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000032:analysis; D009379:Neoplasms, Muscle Tissue / Q000175:diagnosis* / Q000378:metabolism; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000378:metabolism
D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins