Acute lymphoblastic leukemia. Possible origin from a mediastinal germ cell tumor.
The case of acute lymphoblastic leukemia developing shortly after the diagnosis and treatment of a mediastinal germ cell tumor, is reported. The close temporal relationship of these two rare diseases and the presence of a population of mononuclear cells with features of lymphoblasts in the resected germ cell tumor, suggest that the leukemic process originated from the mediastinal tumor.
D000293:Adolescent; D006801:Humans; D007945:Leukemia, Lymphoid / Q000209:etiology* / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000473:pathology; D009373:Neoplasms, Germ Cell and Embryonal / Q000150:complications* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000473:pathology*