Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences.
Three 8-base pair (bp) segments of alternating purine-pyrimidine from the simian virus 40 enhancer region form Z-DNA on negative supercoiling; minichromosome DNase I-hypersensitive sites determined by others bracket these three segments. A survey of transcriptional enhancer sequences reveals a pattern of potential Z-DNA-forming regions which occur in pairs 50-80 bp apart. This may influence local chromatin structure and may be related to transcriptional activation.
D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex; D001483:Base Sequence; D002460:Cell Line; D002522:Chlorocebus aethiops; D004278:DNA, Superhelical / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D005809:Genes, Regulator; D005814:Genes, Viral; D007668:Kidney; D012190:Retroviridae / Q000235:genetics; D013539:Simian virus 40 / Q000235:genetics*; D013045:Species Specificity; D014158:Transcription, Genetic
D000906:Antibodies; D000936:Antigen-Antibody Complex; D004278:DNA, Superhelical; D004279:DNA, Viral