Coxsackie B virus antibodies in myocardial infarction.
Evidence for the association between Coxsackie B virus infections and myocardial infarction was studied in a prospective follow-up examination. Using the micro neutralization test, 9 (15%) of 59 patients with acute myocardial infarction and 1 (2.6%) of 38 control patients showed a fourfold, or higher, antibody increase in paired serum samples against Coxsackie B1-5 viruses. This difference is significant (p less than or equal to 0.05). None of the patients or controls revealed symptoms of a viral infection during the blood sampling. Virus isolation from throat and feces was negative in all patients and controls. This finding agrees with some previous studies suggesting that the Coxsackie B group may in some cases have a causal role in myocardial infarction, or may act as a triggering factor.
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000302:isolation & purification*; D000956:Antigens, Viral / Q000032:analysis; D003384:Coxsackievirus Infections / Q000150:complications*; D029822:Enterovirus B, Human / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology* / Q000382:microbiology; D011446:Prospective Studies
D000914:Antibodies, Viral; D000956:Antigens, Viral