Stimulation of cyclic AMP and lipolysis in adipose tissue of normal and obese Avy/a mice by LY79771, a phenethanolamine, and stereoisomers.
The stimulation of cyclic AMP and lipolysis by LY79771, a phenethanolamine antiobesity compound, and its 3 stereoisomers in adipose tissue of obese viable yellow mice and normal mice were studied. Both activities were stereo-specific with LY79771, the R,S isomer, and LY79730, the R,R isomer, being more potent than LY103085, the S,S isomer, and LY103672, the S,R isomer. Propranolol, a nonspecific beta-antagonist, completely inhibited the elevation of cyclic AMP and lipolysis whereas atenolol, a specific beta 1 antagonist, inhibited the elevation of cyclic AMP but did not completely inhibit lipolysis. These findings indicate that the elevation of cyclic AMP was mediated by the beta 1-receptor whereas the stimulation of lipolysis was mediated by both the beta 1 and beta 2 receptors. The adipose tissue of the obese viable yellow mice responded to these compounds less than that of the normal mice.
D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D051379:Mice; D009765:Obesity / Q000378:metabolism*; D010627:Phenethylamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D013237:Stereoisomerism
D005230:Fatty Acids, Nonesterified; D010627:Phenethylamines; D015078:2-Hydroxyphenethylamine; D011433:Propranolol; D000242:Cyclic AMP; C033231:LY 79771