title: Experimental transplacental transmission of canine herpesvirus in pregnant bitches during the second trimester of gestation.
abstract: The effects of canine herpesvirus (CHV) on fetuses were studied after IV inoculation of pregnant bitches in the 2nd trimester of gestation. Cesarean sections were performed on 2 bitches that were inoculated with CHV on the estimated 30th day of gestation. Bitch M-1 had 2 mummified fetuses and bitch M-2 had 4 mummified and 2 dead fetuses and 3 live-born pups. Infection by CHV was confirmed histopathologically by the presence of focal areas of necrosis associated with intranuclear inclusion bodies in heart muscle sections of 1 dead fetus; CHV was not recovered from other organs. Abortion occurred between the 2nd and 3rd week after inoculation of another pregnant bitch inoculated with CHV on the estimated 30th day of gestation. Two bitches inoculated with CHV on the estimated 40th day of gestation gave birth prematurely to 10 pups. The detection of characteristic herpesviral lesions in various organs and the reisolation of CHV from the liver, spleen, kidneys, and lungs of premature pups indicated CHV infection. Transplacental infection of fetal pups by CHV resulted in their death and subsequent mummification. It appears that abortion and premature birth also may occur in pregnant bitches infected during the 2nd trimester of gestation.
mesh_terms: D000034:Abortion, Veterinary / Q000209:etiology*; D000818:Animals; D004283:Dog Diseases / Q000473:pathology / Q000635:transmission*; D004285:Dogs; D005260:Female; D005313:Fetal Death / Q000473:pathology / Q000662:veterinary*; D005315:Fetal Diseases / Q000473:pathology / Q000635:transmission / Q000662:veterinary*; D005333:Fetus / Q000473:pathology*; D005865:Gestational Age; D006566:Herpesviridae Infections / Q000473:pathology / Q000635:transmission / Q000662:veterinary*; D002184:Herpesvirus 1, Canid; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000635:transmission / Q000662:veterinary*