[Effect of a number of immunostimulating preparations on the intracellular bactericidal systems of peripheral blood neutrophils].
Administration of methyluracil (20 mg/kg), dibasol (2 mg/kg), prodigiosan (5 micrograms/kg) and levamisole (2.5 mg/kg) to rabbits was followed by stimulation of phagocytic activity of peripheral blood neutrophils. As regards the degree of the effect, the drugs might be arranged in the following way: prodigiosan greater than levamisole greater than methyluracil greater than dibazol. The induction effects of levamisole and prodigiosan on the activity of the myeloperoxidase bactericidal system and alkaline phosphatase in leukocytes correlated with an increase in their functional activity. In contrast to the drugs indicated, the phagocytosis-stimulating action of methyluracil on peripheral blood neutrophils was not apparently mediated via the bactericidal systems studied but via other mechanisms one of which might be activation of nucleo- and proteinosynthesis. In the dose indicated dibasol did not produce any essential effect on the phagocytic response and intracellular bactericidal systems of phagocytes. All the drugs under study did not produce any effect on the neutrophil content of non-enzymatic cation proteins.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D009195:Peroxidase / Q000097:blood; D010587:Phagocytosis / Q000187:drug effects*; D011817:Rabbits; D013211:Staphylococcus aureus; D013997:Time Factors
D000276:Adjuvants, Immunologic; D001798:Blood Proteins; D009195:Peroxidase; D000469:Alkaline Phosphatase
Vliianie riada immunostimuliruiushchikh preparatov na nekotorye vnutrikletochnye bakteritsidnye sistemy neĭtrofilov perifericheskoĭ krovi.