[Antidiuretic hormone inhibitor in the cells of the frog bladder and its sorption].
The water flow according to the osmotic gradient increased under the action of 1 mU/ml of antidiuretic hormone (ADH) from 0,049 +/- 0.017 to 1.31 +/- 0.29 mcl/cm2 min in the presence of hemosorbent SKN in the solution of the frog bladder serous membrane and from 0.054 +/- 0.015 to 0.67 +/- 0.15 mcl/cm2 min without a sorbent. The effect of polyethylene glycol 400 hyperosmotic solution on the water, cAMP and theophylline penetration was not intensified after hemosorbent use. ADH inhibitor-binding substances are present in the blood serum. The data obtained allow one to conclude that ADH enhances the water penetration, stimulating at the same time the release of the inhibitor, lowering its interaction with the receptor. Such a selfregulation is absent in the presence of hemosorbent, absorbing ADH inhibitor.
D000042:Absorption; D000818:Animals; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D006727:Hormone Antagonists / Q000378:metabolism*; D011896:Rana temporaria; D011956:Receptors, Cell Surface / Q000378:metabolism*; D001743:Urinary Bladder / Q000166:cytology* / Q000378:metabolism; D014667:Vasopressins / Q000037:antagonists & inhibitors*
D006727:Hormone Antagonists; D011956:Receptors, Cell Surface; D014667:Vasopressins
Ingibitor antidiureticheskogo gormona v kletkakh mochevogo puzyria liagushki i ego sorbtsiia.