Pseudomonas aeruginosa and Acinetobacter calcoaceticus: in vitro susceptibility of 150 clinical isolates to five beta-lactam antibiotics and tobramycin.
The in vitro activities of azlocillin, carbenicillin, ceftriaxone, piperacillin, N-formimidoyl thienamycin (N-f thienamycin) and tobramycin have been compared against clinical isolates of Pseudomonas aeruginosa (n = 100) and Acinetobacter calcoaceticus (n = 50). An agar dilution method was employed for measurement of minimal inhibitory concentration (MIC). Tobramycin was the most active drug against P. aeruginosa (MIC less than or equal to 2 mg/l). Of the beta-lactam antibiotics, N-f thienamycin and tobramycin were highly active against A. calcoaceticus (MIC less than or equal to 2 mg/l), although one isolate was resistant to tobramycin (MIC greater than 16 mg/l). The other drugs were only moderately active against A. calcoaceticus.
D000150:Acinetobacter / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001390:Azlocillin; D002228:Carbenicillin / Q000494:pharmacology; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000494:pharmacology; D002443:Ceftriaxone; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology; D014031:Tobramycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010406:Penicillins; D013845:Thienamycins; D002443:Ceftriaxone; D002228:Carbenicillin; D001390:Azlocillin; D002439:Cefotaxime; D014031:Tobramycin; D010878:Piperacillin