Action of the e locus of mice in the response of phaeomelanic hair follicles to alpha-melanocyte-stimulating hormone in vitro.
Dibutyryl adenosine 3',5'-monophosphate (dibutyryl cyclic AMP) induced eumelanin synthesis in hair bulb melanocytes of recessive yellow (e/e) mice in vitro, whereas alpha-melanocyte-stimulating hormone (alpha-MSH) did not. In contrast, the melanocytes of lethal yellow (Ay/a) mice produced eumelanin in response to both dibutyryl cyclic AMP and alpha-MSH. These results suggest that the e locus controls a mechanism that determines the function of an alpha-MSH receptor.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D005808:Genes, Recessive; D005838:Genotype; D006197:Hair / Q000187:drug effects*; D008543:Melanins / Q000096:biosynthesis / Q000235:genetics*; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D008544:Melanocytes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL
D008543:Melanins; C016042:phaeomelanin; D003994:Bucladesine; D009074:Melanocyte-Stimulating Hormones