The capsid antigen of Epstein-Barr virus in nasopharyngeal carcinomas: comparison of serum antibody titre, cellular antigen content and histopathology.
In a retrospective study of 21 patients with nasopharyngeal malignancies (lymphoepithelial carcinomas, both undifferentiated and dedifferentiated serological and immunohistological methods were used to examine the significance of the IgG- and IgM-antibody against the capsid antigen of Epstein-Barr virus for early detection and follow-up, and the findings compared with those from a control group. Furthermore, the IgA-antibody is taken into account and presented with examples from the literature. Other possible forms of therapy (combined radio- and polychemotherapy) are also discussed.
D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D002213:Capsid / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D009303:Nasopharyngeal Neoplasms / Q000276:immunology*; D012189:Retrospective Studies
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M