Is akathisia a forerunner of tardive dyskinesia? A clinical report with brief review of literature.
k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia. The authors propose that differential involvement of dopamine systems may account for the transition from akathisia to tardive dyskinesia. In the light of a brief review of literature, a prospective study of akathisia and tardive dyskinesia seems justified.
D017109:Akathisia, Drug-Induced; D004359:Drug Therapy, Combination; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D008297:Male; D008875:Middle Aged; D011398:Promethazine / Q000008:administration & dosage; D011595:Psychomotor Agitation / Q000188:drug therapy; D014282:Trihexyphenidyl / Q000008:administration & dosage
D014282:Trihexyphenidyl; D008094:Lithium; D011398:Promethazine