Cyclic AMP and anaerobic gene expression in E. coli.
The expression of the fumarate reductase system of Escherichia coli is completely dependent on the presence of adenylate cyclase or cyclic AMP, but the cyclic AMP receptor protein (CRP) is not required. This suggests that cyclic AMP may function as an effector for a second gene activator protein, possibly Fnr, and thus form part of a redox-sensitive regulatory mechanism controlling the expression of anaerobic respiratory functions.
D000262:Adenylyl Cyclases / Q000235:genetics / Q000502:physiology; D000693:Anaerobiosis; D000242:Cyclic AMP / Q000502:physiology*; D004579:Electron Transport; D004926:Escherichia coli / Q000235:genetics*; D005786:Gene Expression Regulation; D008660:Metabolism; D009097:Multienzyme Complexes / Q000235:genetics*; D009154:Mutation; D011953:Receptors, Cyclic AMP / Q000235:genetics / Q000502:physiology; D013385:Succinate Dehydrogenase / Q000235:genetics*
D009097:Multienzyme Complexes; D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP; C033727:fumarate reductase complex; D013385:Succinate Dehydrogenase; D000262:Adenylyl Cyclases