Regional distribution of [3H]imipramine binding sites in the CNS of Roman high and low avoidance rats.
The high affinity binding of [3H]imipramine to membranes was compared in 7 brain regions from two psychogenetically selected rat lines (RHA/Verh, RLA/Verh). A significantly higher binding in RHA/Verh rats, as compared to RLA/Verh rats, was found in cortex and striatum. All other regions, except hypothalamus, showed a trend in the same direction (RHA/Verh greater than RLA/Verh). In the hypothalamus, however, [3H]imipramine binding for RLA/Verh rats significantly exceeded that found in RHA/Verh animals.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins; D008297:Male; D051381:Rats; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor