Selective inhibitory effect of two 2-nitronaphthofuran derivatives on growth and induction of transformation of Rous sarcoma virus-infected chicken embryo fibroblasts.
Two 2-nitronaphthofuran derivatives exhibited a dose-dependent lethal effect on Rous sarcoma virus-tranformed chicken embryo fibroblasts. When they were added at time of infection, they prevented cell transformation, but not virus replication, in a dose-dependent manner. Since the two derivatives inhibited mainly the DNA sythesis, we assume that they altered some early DNA-dependent cell event required for cell transformation and not for the integration of provirus.
D000818:Animals; D001358:Avian Sarcoma Viruses; D002472:Cell Transformation, Viral / Q000187:drug effects*; D002642:Chick Embryo; D005347:Fibroblasts / Q000187:drug effects; D009153:Mutagens; D009581:Nitrofurans / Q000494:pharmacology*; D009696:Nucleic Acids / Q000096:biosynthesis; D014176:Protein Biosynthesis; D014779:Virus Replication / Q000187:drug effects
D009153:Mutagens; D009581:Nitrofurans; D009696:Nucleic Acids; C030911:2-nitro-7-methoxynaphtho(2-1b)furan; C011496:2-nitro-8-methoxynaphtho(2,1-b)furan