Interactions of asbestos-activated macrophages with an experimental fibrosarcoma.
Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro.
D015720:5'-Nucleotidase; D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D017638:Asbestos, Crocidolite; D017632:Asbestos, Serpentine; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000201:enzymology; D005354:Fibrosarcoma / Q000503:physiopathology*; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009708:Nucleotidases / Q000378:metabolism; D013997:Time Factors
D017632:Asbestos, Serpentine; D017638:Asbestos, Crocidolite; D001194:Asbestos; D009708:Nucleotidases; D000135:Acid Phosphatase; D015720:5'-Nucleotidase