2-Amino-4-phosphonobutyrate selectively blocks mossy fiber-CA3 responses in guinea pig but not rat hippocampus.
The acidic amino acid antagonist D,L-2-amino-4-phosphonobutyrate (DL-APB) is a potent blocker of synaptic transmission at guinea pig but not rat mossy fiber-CA3 synapses in hippocampal slices. The L-isomer of APB is responsible for the potent inhibition at the guinea pig synapse. The L-APB analogue L-serine-O-phosphate (L-SOP) also is more potent against the guinea pig response. These differences may reflect a difference in a synaptic acidic amino acid receptor in these two species. Other acidic amino acid antagonists are less potent than APB or L-SOP and do not discriminate between the mossy fiber responses in the two species.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004151:Dipeptides / Q000494:pharmacology; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D007736:Kynurenic Acid / Q000494:pharmacology; D010768:Phosphoserine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013237:Stereoisomerism; D009435:Synaptic Transmission / Q000187:drug effects*
D000613:Aminobutyrates; D004151:Dipeptides; D010768:Phosphoserine; C028929:gamma-glutamylglycine; D007736:Kynurenic Acid; C012729:2-amino-4-phosphonobutyric acid