Aging, diazepam exposure and benzodiazepine receptors in rat cortex.
Densities of two benzodiazepine receptor subtypes (BDZ1 and BDZ2) in the frontal cortex of 10- and 27-month-old male Fischer-344 rats were nearly identical. Acute diazepam pretreatment produced a 73% increase in receptor density in the aged rats, mainly in the BDZ2 sites, whereas with the normal adult rat the density increased 42%, primarily due to stimulation of BDZ1 sites. Chronic exposure elicited similar increases of 28-29% in both normal and aged rats but there were subtle differences in the distribution of specific receptors. This study demonstrates a definite effect of age on the response of benzodiazepine receptors to diazepam pretreatment.
D000367:Age Factors; D000818:Animals; D002540:Cerebral Cortex / Q000032:analysis / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011963:Receptors, GABA-A
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D003975:Diazepam