[Inhibition of cyclic nucleotide phosphodiesterase from rabbit heart by hydroxypyridines].
3-Hydroxypyridines, which are inhibitors of cyclic nucleotide phosphodiesterase, affected reversibly and non-competitively the enzyme molecule as compared with cAMP. A number of substances was found exhibiting high inhibitory and antioxidant activities, high inhibitory and low antioxidant activities, as well as low inhibitory and high antioxidant activities. Elucidation of the 3-hydroxypyridines action via antioxidant or phosphodiesterase pathways became possible.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D007700:Kinetics; D009206:Myocardium / Q000201:enzymology*; D011725:Pyridines / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D011725:Pyridines; C014047:hydroxypyridines; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Ingibirovanie fosfodiésterazy tsiklicheskikh nukleotidov iz serdtsa krolika oksipiridinami.