Bioelectrical properties of cerebellar Purkinje cells in reeler mutant mice.
Electroresponsive properties of intracellularly recorded Purkinje cells (PCs) in reeler mice were studied by using sagittal cerebellar slices maintained in vitro. In normally as well as in abnormally located PCs, fast spikes and slower rising multiphasic spikes were elicited by depolarizing currents, and they were abolished by tetrodotoxin and by cadmium respectively. This demonstrates that these neurons, as PCs in normal animals, do have sodium- and calcium-dependent spikes, thus indicating that these bioelectrical properties do not depend on the connectivity of PCs.
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006824:Hybridization, Genetic; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants; D011689:Purkinje Cells / Q000502:physiology*; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D012964:Sodium; D002118:Calcium