title: Increase of transferrin receptors in regenerating rat liver cells after partial hepatectomy.
abstract: The change of transferrin receptors in regenerating rat liver cells after partial hepatectomy was demonstrated. The binding of 125I-labeled transferrin to the cells began to increase after 24 h of partial hepatectomy and reached about double that of the non-operated normal rat liver cells. A Scatchard analysis of binding parameters showed 1.62 X 10(5) (Ka: 1.04 X 10(7) M-1) in normal cells and 3.36 X 10(5) (Ka: 1.23 X 10(7) M-1) in regenerating cells. This reflected on increase of transferrin receptor number and little change occurred in the binding affinity between transferrin and its surface receptor.
mesh_terms: D000818:Animals; D002455:Cell Division; D006498:Hepatectomy; D008099:Liver / Q000033:anatomy & histology / Q000166:cytology; D008115:Liver Regeneration; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011990:Receptors, Transferrin
chemical_list: D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin