Role of the right vagal nerve trunk in antinociception.
Activation of the cardiopulmonary reflex arc by volume expansion results in antinociception of the tail-flick response to radiant heat, and this antinociception can be attenuated by resection of the right vagal nerve trunk. Resection of the right vagal nerve trunk also attenuates foot-shock induced analgesia ( FSIA ), but this vagal influence appears to be qualitatively different from that produced by volume expansion. These findings indicate that pain perception is modulated by cardiovascular input.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002319:Cardiovascular System / Q000294:innervation; D008297:Male; D009433:Neural Inhibition; D009619:Nociceptors / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000502:physiology; D009435:Synaptic Transmission; D014630:Vagus Nerve / Q000502:physiology*