Genetic control of adrenergic receptors on human platelets. A twin study.
It was examined whether genetic factors are involved in the expression of alpha-2 adrenergic receptors on human platelets, as measured with 3H-yohimbine as ligand. The twin series comprised 17 monozygotic and 15 dizygotic adult, healthy, male, drug-free twin pairs. For control of intraindividual and interassay variation, 13 unrelated pairs of subjects were examined. Bmax values for 3H-yohimbine binding (range 91-305 fmol/mg protein) proved to be under considerable genetic control; this was not the case for KD values. Different possible genetic mechanisms are discussed.
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D011247:Pregnancy; D011941:Receptors, Adrenergic / Q000235:genetics*; D011942:Receptors, Adrenergic, alpha / Q000235:genetics* / Q000378:metabolism; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D015016:Yohimbine / Q000378:metabolism
D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine