[Determination of urinary xanthurenic acid after oral loading of L-tryptophan in 88 cases of photodermatosis].
Disturbances in the kynurenine pathway are present in pellagra and pellagroid syndromes. In 88 photodermatoses, the authors found increased urinary excretion of xanthurenic acid after oral load of tryptophan in a number of light-induced eruptions, i.e. benign summer photodermatosis (40%), polymorphous light eruptions (37%), and persistent light reactions (36%) as well as in patients with acute alcoholic intoxication. These biochemical abnormalities in the kynurenine pathway allow for a pathogenetic approach in some photodermatoses.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D006837:Hydroa Vacciniforme / Q000378:metabolism; D007736:Kynurenic Acid / Q000031:analogs & derivatives* / Q000652:urine; D007737:Kynurenine / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000378:metabolism*; D011736:Pyridoxine / Q000097:blood; D014364:Tryptophan / Q000008:administration & dosage / Q000378:metabolism*; D014977:Xanthurenates
D014977:Xanthurenates; D007737:Kynurenine; C028330:xanthurenic acid; D014364:Tryptophan; D007736:Kynurenic Acid; D011736:Pyridoxine
Dosage de l'acide xanthurénique urinaire après épreuve de charge en L-tryptophanne dans quatre-vingt-huit photodermatoses.