Effects of sodium bicarbonate and hydrochlorothiazide on the hypercalciuric action of 1,25(OH)2D3 in the rat.
The hypercalcaemic and hypercalciuric effects of high doses of 1,25(OH)2D3 (50 nanograms per day for 7 days) were studied in rats taking a standard basal diet, with or without supplements of NaHCO3 (4.5 mmoles per day), hydrochlorothiazide (10 milligrams per kilogram body weight per day), or both NaHCO3 and hydrochlorothiazide. 1,25(OH)2D3 elevated plasma and urinary calcium values. The degree of hypercalcaemia elicited was similar in all groups but hypercalciuria was less in groups given NaHCO3 or hydrochlorothiazide. It is suggested that NaHCO3, like thiazide diuretics, might be useful in limiting hypercalciuria in stone-formers with elevated plasma levels of 1,25(OH)2D3.
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002117:Calcitriol / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood / Q000652:urine*; D004032:Diet; D004347:Drug Interactions; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017693:Sodium Bicarbonate; D013997:Time Factors
D001639:Bicarbonates; D006852:Hydrochlorothiazide; D017693:Sodium Bicarbonate; D002117:Calcitriol; D002118:Calcium