title: [Double-blind comparative study of slow-release ketoprofen tablets and indomethacin in coxarthrosis and gonarthrosis].
abstract: Effectiveness and tolerance of Bi-Profenid 150 mg were investigated in osteoarthritis of the hip and knee in 20 patients. This double blind trial compared Bi-Profenid, given in two daily 150 mg doses, to indomethacin in two daily 50 mg doses. Each patient was given both treatment regimens successively for 7 days each, with the order being determined at random. The effectiveness of Bi-Profenid and indomethacin was statistically comparable on the criteria studied: walking distance, pain upon passive mobilization, and assessment of pain on the pain scale. Tolerance proved satisfactory for both drugs. However, scores demonstrated a superiority for ketoprofen in 8 of 20 patients as compared to 5 of 20 for indomethacin.
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006621:Hip Joint; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007660:Ketoprofen / Q000627:therapeutic use*; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010666:Phenylpropionates / Q000627:therapeutic use*; D011897:Random Allocation; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D010666:Phenylpropionates; D013607:Tablets; D007660:Ketoprofen; D007213:Indomethacin
vernacular_title: Etude comparative en double anonymat du kétoprofène comprimés à libération prolongée et de l'indométacine dans la coxarthrose et la gonarthrose.