PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001569:Benzodiazepines / Q000378:metabolism*; D001640:Bicuculline; D001921:Brain / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D004336:Drug Antagonism; D005445:Flunitrazepam / Q000378:metabolism; D008297:Male; D051379:Mice; D011804:Quinolines / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D011963:Receptors, GABA-A; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000927:Anticonvulsants; D011804:Quinolines; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid; D005445:Flunitrazepam; C030079:PK 9084; C030078:pipequaline; D003975:Diazepam; D001640:Bicuculline