[GABA-ergic component in the mechanism of action of the psychostimulant sidnocarb].
The psychostimulant sydnocarb administered in single doses of 15 and 25 mg/kg provokes a dose-dependent decrease in the brain GABA content without affecting the concentration of glutamate and aspartate. This effect remains unchanged but does not get potentiated after combined use of sydnocarb and thiosemicarbazide. During chronic 2-week administration of sydnocarb, a significant reduction in the GABA and aspartate content in the brain is detected. The GABA-positive substance valproate does not prevent the stimulant effect of sydnocarb on the motor and orienting activity of animals under "open field conditions". However, the research behavior remains in this case depressed. Sydnocarb reduces, whereas amphetamine prolongs the latent period of GABA-deficient seizures induced by thiosemicarbazide. The biochemical and behavioral data suggest that the GABA-ergic component is involved into the mechanism of the psychostimulant action of sydnocarb.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005971:Glutamates / Q000378:metabolism; D008297:Male; D051379:Mice; D010069:Oxadiazoles / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011963:Receptors, GABA-A; D012663:Semicarbazides / Q000494:pharmacology; D013558:Sydnones / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005971:Glutamates; D010069:Oxadiazoles; D011619:Psychotropic Drugs; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D012663:Semicarbazides; D013558:Sydnones; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; C005151:thiosemicarbazide; D014635:Valproic Acid; D000661:Amphetamine; C009257:sidnocarb
GAMK-ergicheskiĭ komponent v mekhanizme deĭstviia psikhostimuliatora sidnokarba.