Collagen stimulating factors from lung in experimental paraquat poisoning demonstrated in vitro and in vivo.
Collagen stimulating factors, previously described in experimental liver injury and healing skin wounds, have now been found in experimental paraquat lung injury. These factors are active not only in culture but also in vivo. The evidence from this third example of tissue injury points to an important pathological role in chronic inflammation.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000201:enzymology; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008297:Male; D051379:Mice; D010269:Paraquat / Q000506:poisoning*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D010269:Paraquat