title: Nitrous oxide-induced myeloneuropathy.
abstract: A disabling peripheral myeloneuropathy developed in a health professional with a history of chronic exposure and abuse of nitrous oxide. The distinctive clinical symptoms were radicular sensory loss rather than purely distal, and a "reverse" Lhermitte's sign in the absence of signs of specific spinal cord involvement. The entity of nitrous oxide-induced myeloneuropathy is discussed with a review of the literature, as well as present information regarding the etiology, pathophysiology, symptoms, and treatment. In addition, a case report of nitrous oxide-induced myeloneuropathy is presented.
mesh_terms: D000328:Adult; D006801:Humans; D006987:Hypesthesia / Q000139:chemically induced / Q000175:diagnosis; D007866:Leg / Q000294:innervation*; D008297:Male; D009123:Muscle Hypotonia / Q000139:chemically induced; D009132:Muscles / Q000294:innervation; D009609:Nitrous Oxide; D010292:Paresthesia / Q000139:chemically induced / Q000175:diagnosis; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D013118:Spinal Cord Diseases / Q000139:chemically induced* / Q000175:diagnosis; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D009609:Nitrous Oxide