In-vivo hypocalcaemic, hypophosphataemic and hyperlipaemic activities in the common peptide sequence of adrenocorticotrophin, melanocyte-stimulating hormone and lipotrophin.
A heptapeptide solution in acetate buffer (pH = 4, 150 micrograms/kg) of the amino acid sequence common to ACTH, alpha- and beta-MSH and lipotrophin, when injected intravenously into rabbits produced an increase in total lipids, cholesterol and free fatty acids after 1 h and a decrease in plasma calcium and phosphate after 2 h. No significant modification in the amount of creatinine, uric acid, urea, total proteins, CO2, Cl-, K+ or Na+ was observed.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D008055:Lipids / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology*; D010710:Phosphates / Q000097:blood*; D011817:Rabbits
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010446:Peptide Fragments; D010710:Phosphates; D000324:Adrenocorticotropic Hormone; D002784:Cholesterol; C011394:ACTH (4-10); D002118:Calcium