title: [Seminal fluid concentration of ketoconazole and its effect on spermatozoa motility].
abstract: The concentration of Ketoconazole in seminal fluid has been measured in 7 men. The average concentration of 150 ng/g in seminal fluid is much lower than in blood plasma, but for the treatment of candidiasis the concentration in seminal fluid may be too low. A 50-fold higher Ketoconazole-concentration did not disturb sperm motility in 24 men. Therefore there may be no danger for motility of sperms in genital tract of women, for the tested Ketoconazole-concentration was 3-fold higher than the blood serum concentration.
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007654:Ketoconazole / Q000378:metabolism* / Q000627:therapeutic use; D008297:Male; D012661:Semen / Q000378:metabolism*; D013081:Sperm Motility / Q000187:drug effects*; D014010:Tinea Versicolor / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D007654:Ketoconazole
vernacular_title: Die Seminalplasmakonzentration von Ketoconazol und deren Einfluss auf die Spermatozoenmotilität.