Evidence for the possible function of the fluorescent granular perithelial cells in brain as scavengers of high-molecular-weight waste products.
The fluorescent granular perithelium (FGP) of rats and humans under experimental and pathological conditions was examined with the electron microscope. The FGP incorporated high molecular-weight protein (ferritin) and carbon particles administered intraventricularly. In a case of spontaneous cerebral hemorrhage, the FGP was found to contain lipoidal products and minute fragmented cell debris. The FGP in a patient with lipidosis contained pale inclusion bodies. In aged individuals, the inclusion bodies formed irregular larger aggregates.
D000375:Aging; D000818:Animals; D001808:Blood Vessels / Q000648:ultrastructure*; D001921:Brain / Q000098:blood supply*; D002244:Carbon / Q000378:metabolism*; D002543:Cerebral Hemorrhage / Q000473:pathology; D005293:Ferritins / Q000378:metabolism*; D005453:Fluorescence; D005910:Glioma / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000648:ultrastructure*; D008064:Lipidoses / Q000473:pathology; D008854:Microscopy, Electron; D008970:Molecular Weight; D051381:Rats
D002244:Carbon; D005293:Ferritins