Naltrexone prevents footshock-induced performance deficit in rats.
Three experiments demonstrate that inescapable footshock delivered to unrestrained rats produces analgesia as well as performance deficits in subsequent one-way shuttle acquisition. Both the performance and the antinociceptive effects are prevented by pretreatment with as little as 0.1 mg/kg i.p. of the opiate antagonist, naltrexone. These studies suggest that both effects are mediated through opiate receptors with similar underlying naltrexone pharmaco-dynamics.
D000698:Analgesia; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004597:Electroshock; D008297:Male; D009270:Naloxone / Q000031:analogs & derivatives*; D009271:Naltrexone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology
D011957:Receptors, Opioid; D009270:Naloxone; D009271:Naltrexone