The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains.
We have cloned and sequenced cDNA for the receptor that mediates the endocytosis and transcellular transport of IgA and IgM across many glandular epithelia into external secretions. This receptor contains five extracellular domains which are strikingly homologous to each other and to immunoglobulin variable regions.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis*; D004262:DNA Restriction Enzymes; D004705:Endocytosis; D005260:Female; D007070:Immunoglobulin A / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism*; D008099:Liver / Q000276:immunology; D008321:Mammary Glands, Animal / Q000276:immunology; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics; D011817:Rabbits; D011971:Receptors, Immunologic / Q000235:genetics* / Q000378:metabolism; D013329:Structure-Activity Relationship
D007070:Immunoglobulin A; D007075:Immunoglobulin M; D012333:RNA, Messenger; D011971:Receptors, Immunologic; D004247:DNA; D004262:DNA Restriction Enzymes