title: Prenatal and postnatal exposure to diazepam: effects on opioid receptor binding in rat brain cortex.
abstract: The effects of chronic perinatal or postnatal administrations of diazepam on opiate receptor development in cerebral cortex and striatum were studied at two different post-treatment ages, using tritiated ethylketocyclazocine, the prototypic kappa-opiate, for measurements of opiate binding site ontogeny. Prenatal plus postnatal exposure to diazepam markedly decreased the total number of binding sites for [3H]ethylketocyclazocine in the rat cerebral cortex and striatum at 14 days of age. Postnatal diazepam treatment alone did not alter [3H]ethylketocyclazocine binding site development in cortex or striatum. These results suggest that development of opiate receptors in rat brain can be altered by prenatal exposure to diazepam.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects*; D003496:Cyclazocine / Q000031:analogs & derivatives / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D016314:Ethylketocyclazocine; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects* / Q000378:metabolism
chemical_list: D011957:Receptors, Opioid; D016314:Ethylketocyclazocine; D003496:Cyclazocine; D003975:Diazepam