[Mechanism of the cellular transformation of newborn hamsters inoculated with herpes simplex type 2 virus].
Combined virological, antigenic, electron microscopic, and molecular biologic study of the role of an oncovirus, herpes simplex type 2 virus (HSV-2), in the mechanisms of transformation of HSV-2-infected hamster cells was carried out. No expression of genetic information of the oncovirus could be detected. Cell transformation was shown to be associated with persistence and realization of HSV-2 genetic information in the transformed cells.
D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002472:Cell Transformation, Viral; D006224:Cricetinae; D003602:Cytotoxicity, Immunologic; D004279:DNA, Viral / Q000235:genetics; D005786:Gene Expression Regulation; D007114:Immunization; D007694:Killer Cells, Natural / Q000276:immunology; D009693:Nucleic Acid Hybridization; D012190:Retroviridae / Q000235:genetics / Q000276:immunology; D018139:Simplexvirus / Q000235:genetics* / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000956:Antigens, Viral; D004279:DNA, Viral
Izuchenie mekhanizma transformatsii kletok novorozhdennogo khomiachka, inokulirovannykh virusom prostogo gerpesa tipa 2.