An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues.
The presence of S-100 protein was immunohistochemically studied in many types of formalin-fixed and paraffin-embedded tumors (260 cases). Peripheral nerve tumors, i.e., schwannomas, neurofibromas, granular cell tumors, and neurogenic sarcomas were demonstrated to contain variable amounts of S-100 protein in the tumor cell cytoplasm and nuclei. In ganglioneuromas and ganglioneuroblastomas, neoplastic Schwann cells or satellite cells were positive for S-100 protein. About one-half of the cases of carcinoid tumors stained weakly for S-100 protein. In addition to these nervous tissue and carcinoid tumors, chondrosarcoma, chordomas, pleomorphic adenomas of the salivary gland, and Langerhans cell granulomatosis were also shown to produce S-100 protein. In many types of breast tumors and other lesions, S-100 protein positive cells were likely to correspond to the distribution of myoepithelial cells. These results indicate that S-100 protein is not strictly specific to nervous tissue and its tumors; however, the immunohistochemical demonstration of S-100 protein can be a useful diagnostic tool in tumor diagnosis.
D001941:Breast Diseases / Q000378:metabolism; D002276:Carcinoid Tumor / Q000032:analysis; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D009369:Neoplasms / Q000032:analysis*; D009380:Neoplasms, Nerve Tissue / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010525:Peripheral Nerves / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis*
D009419:Nerve Tissue Proteins; D009418:S100 Proteins