Vaccinia rescue of VSV from interferon-induced resistance: reversal of translation block and inhibition of protein kinase activity.
Coinfection with vaccinia virus rescues vesicular stomatitis virus (VSV) from the inhibitory effects of interferon (IFN) in mouse L cells. While vaccinia infection does not significantly affect VSV RNA synthesis, coinfection with vaccinia dramatically increases VSV protein synthesis in IFN-treated cells. Evidence is provided that vaccinia inhibits the activity of the IFN-induced dsRNA-dependent protein kinase.
D000818:Animals; D002472:Cell Transformation, Viral; D007370:Interferon Type I / Q000502:physiology*; D007700:Kinetics; D007739:L Cells / Q000382:microbiology; D051379:Mice; D008970:Molecular Weight; D009522:Newcastle disease virus / Q000502:physiology; D014176:Protein Biosynthesis; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000235:genetics* / Q000302:isolation & purification; D014158:Transcription, Genetic; D014616:Vaccinia virus / Q000235:genetics*; D014721:Vesicular stomatitis Indiana virus / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics / Q000302:isolation & purification
D007370:Interferon Type I; D047428:Protein Kinase Inhibitors; D014764:Viral Proteins; D011494:Protein Kinases