Killing of Aspergillus fumigatus spores and Candida albicans yeast phase by the iron-hydrogen peroxide-iodide cytotoxic system: comparison with the myeloperoxidase-hydrogen peroxide-halide system.
A new fungicidal system composed of ferrous ion, H2O2, and iodide is described and compared with the myeloperoxidase-hydrogen peroxide-halide system. Both systems had similar activity against Aspergillus fumigatus spores and the Candida albicans yeast phase, but only the ferrous ion-hydrogen peroxide-iodide system was inhibited by hydroxyl radical scavengers.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000502:physiology; D002176:Candida albicans / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D005296:Ferrous Compounds / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007454:Iodides / Q000494:pharmacology; D009504:Neutrophils / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects*; D009195:Peroxidase / Q000494:pharmacology; D013170:Spores / Q000187:drug effects
D000935:Antifungal Agents; D005296:Ferrous Compounds; D007454:Iodides; D006861:Hydrogen Peroxide; D009195:Peroxidase