title: Alpha-2 adrenergic receptors on neurones in the region of the lateral reticular nucleus of the rat.
abstract: The spontaneous firing of single neurones in the region of the lateral reticular nucleus was the subject of a pharmacological study employing microiontophoretic and systemic application of adrenoceptor agonists and antagonists. Both iontophoretic noradrenaline and systemic clonidine depressed neuronal firing. The depressions were consistently reversed by the alpha-2 antagonist RX781094. Other adrenergic antagonists, prazosin and sotalol, were ineffective. The results suggest the existence of alpha-2 receptors in this region of the brain.
mesh_terms: D000818:Animals; D003000:Clonidine / Q000494:pharmacology; D004147:Dioxins / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D019329:Idazoxan; D008526:Medulla Oblongata / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects*; D012154:Reticular Formation / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D004147:Dioxins; D011941:Receptors, Adrenergic; D005680:gamma-Aminobutyric Acid; D003000:Clonidine; D009638:Norepinephrine; D011224:Prazosin; D019329:Idazoxan