title: Circadian rhythms of four marker enzymes activity of the jejunal villi in man.
abstract: Bioptic specimens taken from the lower duodenum were studied in 12 volunteers at different times of the day for the activity of 4 marker enzymes. The activity of alkaline phosphatase in brush border of villi was the strongest at 06h, while the nadir at 22h; acid phosphatase activity in the supranuclear zone and in macrophages was the strongest at 06h and reduced at other test times; the peak activity of 5' nucleotidase was found at 14h with the nadir at 02h; activity of NADPH was the strongest at 18h. It is suggested that circadian rhythmicity of intestinal function exists in man like in animals.
mesh_terms: D015720:5'-Nucleotidase; D000135:Acid Phosphatase / Q000032:analysis; D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D002940:Circadian Rhythm; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D007583:Jejunum / Q000201:enzymology*; D008871:Microvilli / Q000201:enzymology; D009249:NADP / Q000032:analysis; D009708:Nucleotidases / Q000032:analysis; D013997:Time Factors
chemical_list: D009249:NADP; D009708:Nucleotidases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D015720:5'-Nucleotidase