[Synthesis of various acyclic analogs of pyrimidine nucleosides].
As acyclic analogues of pyrimidine nucleosides, 1-[2-(2,3- dihydroxypropyloxy )ethyl]pyrimidines (III a-c) and 1-[[3-(2,3- dihydroxypropyloxy )-2-hydroxy]propyl]pyrimidines (III d-f) were synthesized and tested for in vitro activity against herpes simplex virus type 1. The compounds exhibited no significant antiherpetic activity.
D000998:Antiviral Agents / Q000138:chemical synthesis*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides
Sintesi di alcuni analoghi aciclici di nucleosidi pirimidinici.