title: Alteration of c-myc chromatin structure by avian leukosis virus integration.
abstract: The most common sites of integration of the leukosis virus (ALV) long terminal repeat (LTR) in bursal lymphomas and derivative cell lines correspond to a region encompassed by two major hypersensitive sites in the 5' flanking region of the pre-integration, unrearranged c-myc gene. After integration of the ALV LTR, the major hypersensitive site within the avian c-myc oncogene region is within the proviral LTR, and the major hypersensitive sites normally found in uninfected cells 5' to the first c-myc coding exon are no longer detectable.
mesh_terms: D000818:Animals; D001354:Avian Leukosis Virus / Q000235:genetics*; D002460:Cell Line; D002843:Chromatin / Q000648:ultrastructure*; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000235:genetics; D003851:Deoxyribonucleases; D005786:Gene Expression Regulation; D005796:Genes; D009857:Oncogenes; D011995:Recombination, Genetic
chemical_list: D002843:Chromatin; D004279:DNA, Viral; D003851:Deoxyribonucleases; D004262:DNA Restriction Enzymes