Asbestos affects the in vitro uptake and detoxification of aromatic compounds.
A number of mineral dusts were tested for their ability to catalyze the transformation of benzo(a)pyrene from the microcrystalline state into lipid solution. The findings of Lakowicz and his co-workers, that fibrous dusts were more active than nonfibrous dusts, were confirmed. Macromolecular binding metabolites of BaP were formed in A549 cells to a similar extent whether the BaP was added in solution or adsorbed to fibers; however, the level of water-soluble metabolites was lower in cultures treated with adsorbed hydrocarbon. It was found that asbestos can also inhibit the accumulation of 1-naphthyl glucuronide in cultures treated with 1-naphthol. The significance of this in asbestos pathogenesis is briefly discussed.
D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D008862:Microsomes, Liver / Q000378:metabolism; D009284:Naphthols / Q000378:metabolism; D011083:Polycyclic Compounds / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000378:metabolism; D051381:Rats
D001580:Benzopyrenes; D009284:Naphthols; D011083:Polycyclic Compounds; D001194:Asbestos; C029350:1-naphthol; D001564:Benzo(a)pyrene