Ethylisopropyl-amiloride: a new and highly potent derivative of amiloride for the inhibition of the Na+/H+ exchange system in various cell types.
Ethylisopropyl-amiloride is 100 times more potent than amiloride for inhibiting the Na+/H+ exchanger of 3T3 fibroblasts, chick skeletal muscle cells and chick cardiac cells. Half-maximum effects, measured at 3 mM external Na+ are observed at 20-100 nM and 5 microM for ethylisopropyl-amiloride and amiloride respectively. As previously observed for amiloride, the effect of ethylisopropyl-amiloride is antagonized by external Na+ ions.
D000584:Amiloride / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D051379:Mice; D011719:Pyrazines / Q000494:pharmacology*; D017923:Sodium-Hydrogen Exchangers; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D011719:Pyrazines; D017923:Sodium-Hydrogen Exchangers; D000584:Amiloride; C039614:ethylisopropylamiloride