The role of cyclic nucleotides and related compounds in nerve-mediated vasodilatation in the cat submandibular gland.
1 Intra-arterial administration of a number of purine compounds to the cat submandibular salivary gland led to an increased blood flow. The threshold concentration of the most potent vasodilators, adenosine 5'-triphosphate (ATP) and adenosine 5'-diphosphate (ADP) was about 2 mumol/l. Adenosine and guanosine 5'-triphosphate (GTP) required about 25 mumol/l, adenosine 3',5'-cyclic monophosphate (cyclic AMP) 40 mumol/l, guanosine 5'-diphosphate (GDP) 125 mumol/l and dibutyryl guanosine 3',5' cyclic monophosphate (db cyclic GMP) 400 mumol/l. Dibutyryl cyclic AMP and cyclic GMP were ineffective. 2 The cyclic nucleotide phosphodiesterase inhibitors, theophylline, papaverine, quinine and 3-isobutyl-1-methylxanthine (IBMX), all acted as vasodilators. 3 When intra-arterial infusion of theophylline or IBMX was combined with sympathetic nerve stimulation, the vasodilatation observed after the stimulus ceased was significantly potentiated. 4 Theophylline and IBMX also potentiated the vasodilatation accompanying parasympathetic nerve stimulation and this response persisted after atropine. 5 These results are discussed in relation to the possible mediators of sympathetic and parasympathetic vasodilatation in the gland.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D004176:Dipyridamole / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D007610:Kallikreins / Q000502:physiology; D008297:Male; D009712:Nucleotides, Cyclic / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000502:physiology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011687:Purines / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects; D013363:Submandibular Gland / Q000098:blood supply* / Q000294:innervation; D013564:Sympathetic Nervous System / Q000502:physiology*; D013806:Theophylline / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D009712:Nucleotides, Cyclic; D010726:Phosphodiesterase Inhibitors; D011687:Purines; D011943:Receptors, Adrenergic, beta; D004176:Dipyridamole; D001285:Atropine; D013806:Theophylline; D007610:Kallikreins