Amdinocillin therapy of experimental animal infections.
Amdinocillin has been shown to have broad coverage in vitro against many strains of Enterobacteriaceae. Synergy has been demonstrated in vitro with several other beta-lactam antibiotics. The rabbit model of meningitis was used to study the in vivo effectiveness of amdinocillin when combined with other beta-lactams for serious infections. Organisms that showed an enhanced in vitro bactericidal effect from the combination of amdinocillin and another beta-lactam showed more rapid elimination of the organisms in vivo.
D000560:Amdinocillin / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004927:Escherichia coli Infections / Q000188:drug therapy; D007710:Klebsiella Infections / Q000188:drug therapy; D007711:Klebsiella pneumoniae; D008581:Meningitis / Q000188:drug therapy; D010397:Penicillanic Acid / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D010397:Penicillanic Acid; D000560:Amdinocillin