The effect of cyclic AMP on the rabbit corneal endothelial fluid pump.
Perfusing preswollen deepithelialized rabbit cornea in vitro on its endothelial side with balanced salt solution containing physiological glucose concentration and 10(-6)M adenosine, we can obtain "temperature reversal" from 500-520 microns to less than 400 microns, during 7 hours. Low concentrations of adenosine improve the fluid pump supposedly by inhibiting adenylate cyclase, since c-AMP inhibits the pump.
D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000502:physiology; D000242:Cyclic AMP / Q000494:pharmacology*; D004727:Endothelium / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D011817:Rabbits; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D000242:Cyclic AMP