Neutralizing antibodies against Coxsackie B viruses in patients with recent onset of type I diabetes.
In a search for Coxsackie B virus-induced, insulin-dependent diabetes mellitus (IDDM) we examined sera from 166 selected patients (age 1-17 years) with recent onset of IDDM for specific neutralizing antibodies. All 166 patients investigated had a clinical history of recent infectious illness. Eighty per cent of the patients had antibodies against at least one Coxsackie B virus type. But even among the children studied with antibody titers higher than 256 only in about 44% could a recent Coxsackie B virus infection be serologically demonstrated by determining specific neutralizing IgM antibodies. This result again strengthens the notion that IDDM includes several different etiologic groups, among others possibly Coxsackie B virus infections.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D029822:Enterovirus B, Human / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D013997:Time Factors
D000914:Antibodies, Viral; D007075:Immunoglobulin M