The superoxide free radical: its biochemistry and pathophysiology.
The partial reduction of molecular oxygen in biologic systems produces the cytotoxic intermediates superoxide, hydrogen peroxide, and hydroxyl radical. The superoxide radical is now recognized to play significant roles in a number of pathophysiologic states including oxygen toxicity, radiation damage, phagocyte-mediated inflammation, and postischemic injury.
D000818:Animals; D005609:Free Radicals; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism; D007700:Kinetics; D009504:Neutrophils / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010587:Phagocytosis; D011832:Radiation Injuries / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism* / Q000633:toxicity
D005609:Free Radicals; D013481:Superoxides; D010100:Oxygen