Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas.
Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.
D000818:Animals; D001483:Base Sequence; D004262:DNA Restriction Enzymes; D004251:DNA Transposable Elements; D004273:DNA, Neoplasm / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics; D009052:Leukemia Virus, Murine / Q000235:genetics*; D007942:Leukemia, Experimental / Q000382:microbiology*; D008223:Lymphoma / Q000235:genetics / Q000382:microbiology*; D051379:Mice; D008806:Mice, Inbred AKR; D008979:Moloney murine leukemia virus / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D051381:Rats
D004251:DNA Transposable Elements; D004273:DNA, Neoplasm; D004279:DNA, Viral; D004262:DNA Restriction Enzymes