title: Unscheduled DNA synthesis induced by nitrosated ranitidine in primary cultures of rat hepatocytes.
abstract: In vitro, the reaction, in acidified solution, of the histamine H2 receptor antagonist ranitidine with excess nitrite, yielded nitroso derivative(s) eliciting a dose-dependent amount of unscheduled DNA synthesis in primary cultures of rat hepatocytes.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004260:DNA Repair; D004261:DNA Replication / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009152:Mutagenicity Tests; D009153:Mutagens; D009573:Nitrites; D009603:Nitroso Compounds / Q000633:toxicity*; D011899:Ranitidine; D051381:Rats; D012977:Sodium Nitrite
chemical_list: D009153:Mutagens; D009573:Nitrites; D009603:Nitroso Compounds; D011899:Ranitidine; D012977:Sodium Nitrite