Induction of T cell hyporesponsiveness to Bebaru in mice, and abnormalities in the immune responses of progeny of hyporesponsive males.
Non-specific hyporesponsiveness of cytotoxic T cells to alphaviruses and alloantigens was induced in male mice by multiple, large injections, starting at birth, of gamma-inactivated alphavirus, stock-grown in outbred mouse brains. Offspring of matings between 2 out of 17 treated males and normal females also exhibited significant non-specific hyporesponsiveness (in comparison with normal control mice), without prior exposure to gamma-inactivated alphavirus stock.
D000524:Alphavirus / Q000276:immunology; D000818:Animals; D000956:Antigens, Viral / Q000008:administration & dosage; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000235:genetics*; D012737:Sex Factors; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014036:Togaviridae Infections / Q000235:genetics / Q000276:immunology*
D000956:Antigens, Viral