Effects of CCK-8 in the nucleus accumbens.
The electrophysiological effects of CCK-8 were studied in the rabbit nucleus accumbens. CCK-8 was found to influence neurotransmitter (modulator) systems so as to enhance their action. For example, CCK-8 enhanced the effects of stimulation of the glutaminergic pathways, the fimbria. In addition, when CCK-8 was co-administered with dopamine and acetylcholine, their suppressive effect on the fimbria evoked response was enhanced. Therefore, CCK-8 appears to be capable of enhancing the influence of multiple neurotransmitter (modulator) systems.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D004558:Electric Stimulation; D007839:Functional Laterality; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D012686:Septal Nuclei / Q000502:physiology*; D012844:Sincalide / Q000494:pharmacology*
D012844:Sincalide; D000109:Acetylcholine; D004298:Dopamine