title: Site-specific nicking within the adenovirus inverted terminal repetition.
abstract: Site-specific nicking occurs on the l-strand, but not on the r-strand, of the adenovirus left inverted terminal repeat. Nicks are presumably introduced into double- or single-stranded DNA by a cellular endonuclease in an ATP-independent reaction. The consensus nick site has the sequence: (sequence in text).
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D001483:Base Sequence; D004262:DNA Restriction Enzymes; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D004279:DNA, Viral / Q000235:genetics*; D005814:Genes, Viral; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans
chemical_list: D004279:DNA, Viral; D004262:DNA Restriction Enzymes; D004264:DNA Topoisomerases, Type I