Small hepatocellular carcinoma containing many Mallory bodies.
Four cases of small hepatocellular carcinoma (HCC), consisting exclusively of Mallory body (MB)-containing cells, were presented. The MB-containing HCC cells seemed actively proliferating and infiltrated into the surrounding non-neoplastic tissue with a concomitant loss of the hepatic parenchyma, alpha-fetoprotein was immunohistochemically demonstrated in these MB-containing HCC cells. Therefore, the possibility arises that the process by which MBs are formed is a fundamental pathway that on some occasions may be linked with neoplastic transformation.
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D004721:Endoplasmic Reticulum / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged