Benzodiazepine binding to bovine retina.
[3H]Diazepam binds to membrane preparations of the retina, suggesting that benzodiazepine receptors exist in this tissue. The binding characteristics are similar to those known to occur in the brain, with affinity constants in the same range. Unlike the finding in the brain, [3H]diazepam binding in the retina is not stimulated by GABA and other GABA agonists. These findings indicate that benzodiazepine receptors may have a more general function and not only be associated with anxiety or emotional behaviour.
D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D001667:Binding, Competitive; D002417:Cattle; D003975:Diazepam / Q000378:metabolism*; D004644:Emotions / Q000502:physiology; D006801:Humans; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000378:metabolism / Q000502:physiology; D011963:Receptors, GABA-A; D012160:Retina / Q000032:analysis* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D003975:Diazepam