Effect of Clostridium perfringens epsilon toxin on the cardiovascular system of rats.
Pressor activity was demonstrated by the intravenous injection of purified epsilon toxin of Clostridium perfringens type D but not by that of epsilon prototoxin. The activity was completely abolished by C. perfringens type B or D antiserum, but not by type A, C, or E antiserum. The rise in blood pressure caused by the toxin was accompanied by a decrease in the blood flow in skin without any change of heart rate and electrocardiogram readings. These results indicate that epsilon toxin possesses pressor activity as well as lethal and dermonecrotic activities.
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003016:Clostridium perfringens; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D051381:Rats
D001427:Bacterial Toxins; C039811:Clostridium perfringens epsilon-toxin