Brain receptor binding of analogues of gamma-aminobutyric acid (GABA).
This paper reports the synthesis of some 4-(beta-hydroxyalkyl)-gamma-aminobutyric acid analogues (I a-h). The compounds were biologically tested as inhibitors of 3H-GABA binding to rat cortex synaptosomal membranes. The most potent compounds were (I c,d) which exhibited a linear alkyl chain at C4.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011963:Receptors, GABA-A; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000378:metabolism
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid