Behavioral, metabolic and histological aspects of lithium and ethanol interaction.
Behavioral, biochemical and histological techniques were used to evaluate the possible interaction between a lithium salt and ethanol. Injection of a single dosage of ethanol into mice pretreated with LiCl for 14 days enhanced spontaneous locomotor activity for the initial 60 min of testing compared to respective control. Drinking of 0.4% of LiCl solution for 25 consecutive days induced hepatic alcohol dehydrogenase (L-ADH) and aldehyde dehydrogenase (L-ALDH). The LiCl treatment increased Vmax of both enzymes in the same order and magnitude. The apparent Km of L-ADH was increased by LiCl while that of L-ALDH remained unchanged from respective controls. Organ histopathology indicates decreased germinal activity of the mouse spleen by the LiCl treatment. A mild chronic perivascular inflammation and slight hypercellularity of the myocardium was also noted in the heart of LiCl-treated mice.
D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000201:enzymology; D009043:Motor Activity / Q000187:drug effects*; D013154:Spleen / Q000187:drug effects
D002712:Chlorides; D000431:Ethanol; D008094:Lithium; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase; D018021:Lithium Chloride