Hepatitis A virus immunoglobulin M antibody in acute neurological disease.
Sera from 167 patients with Guillain-Barré syndrome, 224 patients with other neurological diseases, and 10 normal subjects were tested for hepatitis A virus-specific immunoglobulin M antibodies. Two patients with classic Guillain-Barré syndrome and 1 patient with acute myeloradiculopathy had high titers of virus-specific IgM antibody. All three patients had jaundice and laboratory evidence of liver involvement before the onset of the neurological disease. None of the other sera from patients with Guillain-Barré syndrome or control subjects were positive for hepatitis A virus.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis* / Q000276:immunology; D006506:Hepatitis A / Q000150:complications; D006507:Hepatovirus / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D009422:Nervous System Diseases / Q000276:immunology; D011129:Polyradiculoneuropathy / Q000209:etiology / Q000276:immunology*
D000914:Antibodies, Viral; D007075:Immunoglobulin M