Sodium-independent taurine binding to brain synaptic membranes.
Saturable sodium-independent taurine binding to mouse and rat brain synaptic membranes was exposed after two freezing-thawing cycles combined with Triton X-100 treatments. The amount of saturable taurine binding was fairly low but was enhanced after depletion of brain taurine. Saturable taurine binding was displaceable by some convulsants and anticonvulsants but is specificity still remains to be established.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D008297:Male; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012964:Sodium / Q000502:physiology; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D017981:Receptors, Neurotransmitter; D013654:Taurine; C009558:taurocyamine; D012964:Sodium