Transposition of a gene encoding OXA-2 beta-lactamase.
A bla gene encoding OXA-2 beta-lactamase has been transposed from the Salmonella typhimurium R plasmid R1767. This transposable element which was designated Tn2410 encoded sulphonamide and mercury resistance in addition to the bla gene. It had a size of 18.5 kb and appeared to be flanked by small inverted repeats. Restriction enzyme analysis resulted in a detailed map of Tn2410, which showed a high degree of similarity with the published map of Tn2603, a transposon encoding OXA-1 beta-lactamase. The ampicillin and sulphonamide resistance genes on Tn2410 were mapped in a cluster on the region between the centre and the righ end of the map.
D000667:Ampicillin / Q000494:pharmacology; D004262:DNA Restriction Enzymes; D004251:DNA Transposable Elements; D004269:DNA, Bacterial / Q000235:genetics; D004274:DNA, Recombinant; D005798:Genes, Bacterial; D010068:Oxacillin; D011815:R Factors; D012486:Salmonella typhimurium / Q000235:genetics; D013449:Sulfonamides / Q000494:pharmacology; D001618:beta-Lactamases / Q000378:metabolism*
D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D004274:DNA, Recombinant; D013449:Sulfonamides; D000667:Ampicillin; D004262:DNA Restriction Enzymes; C039404:beta-lactamase OXA-2; D001618:beta-Lactamases; D010068:Oxacillin