title: A murine model for oral infection with a primate rotavirus (simian SA11).
abstract: Simian rotavirus SA11 was shown to replicate in the gastrointestinal tracts of infant mice after oral inoculation. Clinical symptoms, histopathological changes in the small intestinal mucosa, and the type-specific humoral immune response were all characteristic of rotavirus-induced gastroenteritis. The availability of this small animal model for the study of a primate rotavirus infection should expedite analysis of the immune response necessary for protection against challenge.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D003967:Diarrhea / Q000382:microbiology; D004195:Disease Models, Animal; D007082:Ileum / Q000473:pathology; D051379:Mice; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000503:physiopathology*
chemical_list: D000914:Antibodies, Viral