[Effect of riboxine on myocardial metabolism in conditions of altitude hypoxia].
Riboxine stimulates activation of redox biosynthetic processes and raises aerobic production of energy in rat myocardium. Under pressure chamber hypoxia corresponding to the altitude 6000 m, riboxine promotes the correction of metabolic acidosis, normalization of the ultrastructure of cardiomyocytes and more balanced development of heart hypertrophy.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000532:Altitude Sickness / Q000188:drug therapy*; D000818:Animals; D006332:Cardiomegaly / Q000517:prevention & control; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D006003:Glycogen / Q000378:metabolism; D000860:Hypoxia / Q000188:drug therapy*; D007288:Inosine / Q000627:therapeutic use*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D007288:Inosine; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases
Vliianie riboksina na metabolizm miokarda v usloviiakh vysotnoĭ gipoksii.