Autoimmunity in endocrine diseases.
The realization that autoimmunity underlies many endocrine disorders of previously unknown etiology has greatly broadened our understanding of the pathogenesis of these diseases. It has provided new explanations for their heredity and their association with particular HLA haplotypes. It has also offered new tools for diagnosing these diseases as well as monitoring their course or predicting their outcome. Finally, establishing the autoimmune basis of these diseases offers new potential for their treatment. The next quarter century of research into immunologic aspects of endocrine diseases promises to be as fruitful as the last.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D001402:B-Lymphocytes / Q000276:immunology; D003920:Diabetes Mellitus / Q000276:immunology; D004700:Endocrine System Diseases / Q000235:genetics / Q000276:immunology*; D005128:Eye Diseases / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000276:immunology; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D008861:Microsomes / Q000276:immunology; D009230:Myxedema / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D011989:Receptors, Thyrotropin; D013601:T-Lymphocytes / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D013966:Thyroiditis / Q000276:immunology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D001324:Autoantigens; D006183:H-2 Antigens; D006680:HLA Antigens; D007328:Insulin; D011956:Receptors, Cell Surface; D011989:Receptors, Thyrotropin; D013954:Thyroglobulin