Selective opiate tolerance in the guinea-pig ileum is not associated with selective dependence.
Opiate dependence attributable to specific types of opiate receptors was studied in the isolated guinea-pig ileum made tolerant/dependent in vivo to a specific narcotic agonist. Apparently, induction of dependence of mu-receptors was associated with dependence of kappa-receptors and vice versa. These investigations involved the use of the irreversible mu-receptor antagonist beta-funaltrexamine to provide preparations with functional kappa-receptors only. The documented cross-dependence between different opiate receptor types suggests a common system with which these opiate receptors interact.
D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects*; D009294:Narcotics / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000502:physiology*; D019966:Substance-Related Disorders
D009294:Narcotics; D011957:Receptors, Opioid