Mechanism of the involvement of monoamine oxidase in the regulation of (Na+ + K+)-ATPase in rat brain.
Increasing concentrations of dopamine fail to give a biphasic response to (Na+ + K+)-ATPase activity in various subcellular fractions of rat brain preincubated with monoamine oxidase inhibitors, viz. 1 X 10(-4) M clorgyline and 1 X 10(-4) M deprenyl. The product of the monoamine-oxidase-catalysed reaction with dopamine as substrate is 3-methoxy-4-hydroxyphenylacetaldehyde. An analogue of this product is 3-methoxy-4-hydroxybenzaldehyde. This analogue, when incubated with the subcellular fractions which had been preincubated with monoamine oxidase inhibitors and dopamine, gave a more pronounced biphasic response to (Na+ + K+)-ATPase activity than that observed in the fractions incubated with dopamine alone.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D003010:Clorgyline / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D005421:Flavoring Agents / Q000494:pharmacology; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014018:Tissue Distribution
D005421:Flavoring Agents; D012642:Selegiline; D008995:Monoamine Oxidase; D000254:Sodium-Potassium-Exchanging ATPase; D003010:Clorgyline; D004298:Dopamine