[Effect of beta-endorphin on G-cells in rats with experimental duodenal ulcer].
Immunohistochemistry was used to study the changes in the number of G cells in the antral part of the stomach of rats (40 animals) with cystamine-induced duodenal ulcer treated with beta-endorphine. In the stomach of rats with cystamine-induced ulcer the number of G cells was discovered to be significantly increased, which was removed by an opioid peptide. Naloxone did not block the action of beta-endorphine. Thus, beta-endorphine changes the number of G cells, the drug action being not associated with opiate receptors.
D000818:Animals; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D004723:Endorphins / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology*; D001615:beta-Endorphin
D004723:Endorphins; D005755:Gastrins; D003543:Cysteamine; D001615:beta-Endorphin
Vliianie beta-éndorphina na G-kletki u krys s éksperimental'noĭ iazvoĭ dvenadtsatiperstnoĭ kishki.