The penetration of cefmenoxime into cerebrospinal fluid across non-inflamed meninges.
The penetration of cefmenoxime, a newly-developed cephalosporin, across non-inflamed meninges was studied in 12 volunteers undergoing elective myelograms. Patients received 30 mg/kg of cefmenoxime intravenously every 6 h for three doses. Trough and peak serum levels were drawn just prior to and immediately after the last dose. CSF was obtained from 1 to 4 h after the administration of the last dose and a concomitant serum sample was also drawn. Cefmenoxime levels were determined by a microbiological assay and by high-performance liquid chromatography (HPLC). Cefmenoxime was detected in the CSF of all 12 patients and ranged between 0.15 and 1.4 mg/l.
D001681:Biological Assay; D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D008578:Meninges / Q000378:metabolism*
D015281:Cefmenoxime; D002439:Cefotaxime