title: Increase of GABA receptor binding activity after short lasting monocular deprivation in kittens.
abstract: GABA receptor activity, as measured by [3H]muscimol binding, was investigated in visual and auditory cortex of 5 weeks old kittens with different visual experience. Binocular deprivation since birth did not affect the GABA receptor binding activity. Three days of monocular vision resulted in an increase of [3H]muscimol binding in the visual cortex of both normally reared (144 percent) and binocularly deprived kittens (149 percent). Neither 3 days of normal binocular vision in deprived animals nor 3 days of binocular deprivation in normally reared ones produced significant changes in GABA receptor binding activity. In all experimental conditions [3H]muscimol binding in auditory cortex was similar. We suggest that activation of the GABA-ergic system is due to asymmetric visual input, possibly connected with mechanisms of ocular dominance shift.
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000378:metabolism; D002415:Cats; D009118:Muscimol / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011963:Receptors, GABA-A; D014793:Visual Cortex / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D009118:Muscimol