[Short-term effect of thiazides on magnesium and calcium metabolism and secondarily on that of phosphorus, uric acid, oxalate and cyclic AMP].
Six healthy young volunteers were fed during two period of 9 days each by a strictly constantly liquid formula diet (Fresubin), on an ambulator basis. In a single blind cross-over randomized study, they were given either hydrochlorothiazide, 50 mg p.d., or a placebo during the first seven days of the two periods. The diuretic did not induce significant changes of either magnesemia or magnesiuria. In addition, the magnesium excretion after a challenging intravenous magnesium load remained unchanged. However, the thiazide normally increased the urinary excretion of sodium and potassium. It also induced hypocalciuria and hypercalcemia. The urinary excretion of cAMP and oxalic acid remained stable.
D000328:Adult; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D004232:Diuretics; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D010070:Oxalates / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D010919:Placebos; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014527:Uric Acid / Q000378:metabolism
D004232:Diuretics; D010070:Oxalates; D010919:Placebos; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D014527:Uric Acid; D010758:Phosphorus; D000242:Cyclic AMP; D008274:Magnesium; D002118:Calcium
Influence à court terme des thiazides sur le métabolisme du magnésium, du calcium et accessoirement sur celui du phosphore, de l'acide urique, de l'oxalate et de l'AMP cyclique.