Response of the non-pregnant and pregnant rat uterus to chloroquine in vitro.
The contractility of the uterus is known to vary at different phases of the oestrus cycle and during pregnancy. Chloroquine in low doses produced an initial reduction of the amplitude of spontaneous contraction followed by a dose-dependent increase in the amplitude of contraction and reduction in the rate of contraction of uteri in the proestrus, oestrus and dioestrus phases of the oestrus cycle. Reduction in both the rate and amplitude of contraction was recorded to higher doses on the uterus in the proestrus phase whilst a further increase in amplitude and reduction in rate of contraction were observed on uteri in oestrus and dioestrus phases. Chloroquine produced irregular non-dose-dependent spontaneous contractions of the quiet uterus in early pregnancy.
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D004031:Diestrus / Q000187:drug effects; D004971:Estrus / Q000187:drug effects*; D005260:Female; D008686:Metestrus / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal; D011359:Proestrus / Q000187:drug effects; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
D002738:Chloroquine