Increment in dialysate sodium with sodium chloride or bicarbonate addition.
Hemodialysis was performed in 12 patients for 2 weeks each utilizing acetate dialysate containing 134 mEq/L sodium and dialysate containing 143 mEq/L sodium, achieved by the addition of sodium chloride or sodium bicarbonate to the acetate dialysate. Intradialytic morbidity was lower, dialysis hypoxemia less marked, and predialysis blood pH higher with the bicarbonate-than with the chloride-added dialysate. The long-term use of sodium bicarbonate-added dialysate in three patients was safe. Dialysate pH adjustment was not required. These findings suggest that the addition of sodium bicarbonate (50-75 g) to acetate dialysate may be preferred to sodium chloride for increasing dialysate sodium in selected patients.
D000368:Aged; D001639:Bicarbonates / Q000008:administration & dosage*; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009120:Muscle Cramp / Q000139:chemically induced; D009994:Osmolar Concentration; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D012964:Sodium / Q000032:analysis* / Q000097:blood; D017693:Sodium Bicarbonate; D012965:Sodium Chloride / Q000008:administration & dosage*; D012996:Solutions
D001639:Bicarbonates; D012996:Solutions; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; D012964:Sodium