Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex.
In the presence of ferric ions, doxorubicin forms a complex which self-reduces the iron moiety to form a ferrous complex. This ferrous complex can generate active radicals able to degrade deoxyribose as well as form a species greatly stimulatory towards lipid peroxidation. Both reactions may explain the damage to different sites within the body associated with doxorubicin therapy.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper / Q000378:metabolism; D003855:Deoxyribose / Q000378:metabolism; D004317:Doxorubicin / Q000378:metabolism*; D006878:Hydroxides / Q000378:metabolism*; D017665:Hydroxyl Radical; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D009942:Organometallic Compounds
D006878:Hydroxides; D008054:Lipid Peroxides; D009942:Organometallic Compounds; C041415:doxorubicin-iron complex; D017665:Hydroxyl Radical; D003855:Deoxyribose; D003300:Copper; D004317:Doxorubicin; D007501:Iron