Metabolic imaging of the brain stem and spinal cord: studies with positron emission tomography using 18F-2-deoxyglucose in normal and pathological cases.
A new high resolution positron emission scanner (Neuro-PET) has made possible clear visualization and quantitation of glucose metabolism in the brain stem and upper cervical cord (above C4) using 18F-2-deoxyglucose. The following mean measurements of the glucose utilization rate are based on studies of 34 normal volunteers and patients with no apparent pathology in the brain stem or cord: 5.0 +/- 1.0 (SD) mg Glu/100 g/min for the mesencephalon-upper pons, 3.2 +/- 1.0 for the pons-medulla, and 1.7 +/- 0.6 for the upper cervical cord. (The first value also includes studies done with the ECAT-II scanner.) Resolution of white-gray matter within these structures was not possible. Whenever possible, a correlation was made with autoradiographic data in monkeys, and good agreement was found. The glucose utilization in cases showing brain stem and cord pathology was altered, with marked elevation (as high as 8.2 mg/100 g/min) in cases of high-grade gliomas, and reduction in cases of low-grade gliomas and one pontine hematoma.
D000328:Adult; D000368:Aged; D000818:Animals; D001254:Astrocytoma / Q000000981:diagnostic imaging; D001927:Brain Diseases / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000000981:diagnostic imaging; D001933:Brain Stem / Q000000981:diagnostic imaging*; D003837:Deoxy Sugars; D003847:Deoxyglucose; D005260:Female; D005461:Fluorine; D005909:Glioblastoma / Q000000981:diagnostic imaging; D005910:Glioma / Q000000981:diagnostic imaging; D000882:Haplorhini; D006801:Humans; D008297:Male; D008875:Middle Aged; D011868:Radioisotopes; D013116:Spinal Cord / Q000000981:diagnostic imaging*; D013118:Spinal Cord Diseases / Q000000981:diagnostic imaging; D013120:Spinal Cord Neoplasms / Q000000981:diagnostic imaging; D014055:Tomography, Emission-Computed
D003837:Deoxy Sugars; D011868:Radioisotopes; D005461:Fluorine; D003847:Deoxyglucose