Induction of cross-reactive serum neutralizing antibody to human rotavirus in calves after in utero administration of bovine rotavirus.
Sera from calves infected in utero or postnatally with bovine rotavirus NCDV or postnatally with human rotavirus D (serotype 1) were tested by plaque reduction neutralization assay for antibody to bovine rotavirus and to three serotypes of human rotavirus. Homologous antibody developed in all animals, but antibody to heterologous rotaviruses developed mainly in animals exposed in utero to bovine rotavirus. The development of heterologous antibody may explain the immunological implications for cross-protection, previously observed between bovine and human rotavirus in experimentally infected calves.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002417:Cattle; D003429:Cross Reactions; D005243:Feces / Q000032:analysis / Q000382:microbiology; D005260:Female; D005333:Fetus; D006801:Humans; D007124:Immunoenzyme Techniques; D009500:Neutralization Tests; D011247:Pregnancy; D012401:Rotavirus / Q000276:immunology*; D013045:Species Specificity; D010948:Viral Plaque Assay
D000914:Antibodies, Viral