Inhibition of dimethylnitrosamine-induced mutagenesis in Arabidopsis thaliana by diethyldithiocarbamate and carbon monoxide.
Diethyldithiocarbamate and carbon monoxide markedly inhibited the frequency of embryonic and chlorophyll mutations induced by the metabolism-requiring mutagen dimethylnitrosamine in the higher plant Arabidopsis thaliana. In contrast, the monoamine oxidase substrates, tryptamine, benzylamine and 2-phenylethylamine, had no such effect. The mutagenicity of a direct-acting mutagen, N-methyl-N-nitrosourea, was not altered by these inhibitors or substrates.
D002248:Carbon Monoxide / Q000494:pharmacology*; D004128:Dimethylnitrosamine / Q000633:toxicity*; D004050:Ditiocarb / Q000494:pharmacology*; D008770:Methylnitrosourea / Q000633:toxicity; D009152:Mutagenicity Tests; D009154:Mutation; D010944:Plants / Q000187:drug effects / Q000235:genetics*; D013859:Thiocarbamates / Q000494:pharmacology*
D013859:Thiocarbamates; D008770:Methylnitrosourea; D002248:Carbon Monoxide; D004050:Ditiocarb; D004128:Dimethylnitrosamine