title: Effect of prior immunization on induction of cervial cancer in mice by herpes simplex virus type 2.
abstract: Previous studies at this laboratory showed that repeated application of inactivated herpes simplex virus type 2 to the mouse cevix produced premalignant and malignant lesions. In the present study mice were inoculated with inactivated herpes simplex virus type 2 or control solution and Freund's adjuvant by intraperitoneal and subcuaneous routes before exposure of the cervix to inactivated virus. It appears that immunization with inactivated virus conferred a protection against the induction of cervical carcinoma.
mesh_terms: D000818:Animals; D005260:Female; D006561:Herpes Simplex / Q000150:complications*; D007114:Immunization; D051379:Mice; D018139:Simplexvirus / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*