title: In vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa.
abstract: The in vitro activity of ceftriaxone alone and in combination with gentamicin, tobramycin, and amikacin against 50 Pseudomonas aeruginosa strains was studied by the broth dilution method and the time-kill curve method. The majority of the P. aeruginosa strains tested were resistant to ceftriaxone. Combining ceftriaxone with the aminoglycosides resulted in synergism, antagonism, or indifference.
mesh_terms: D000583:Amikacin / Q000008:administration & dosage / Q000494:pharmacology*; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D002443:Ceftriaxone; D004357:Drug Synergism; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology*; D007612:Kanamycin / Q000031:analogs & derivatives*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D014031:Tobramycin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D005839:Gentamicins; D007612:Kanamycin; D002443:Ceftriaxone; D000583:Amikacin; D002439:Cefotaxime; D014031:Tobramycin