[Effect of euphylline on the cyclic nucleotide content and cAMP phosphodiesterase activity of the lymphocytes of bronchial asthma patients].
The content of cAMP, cGMP and cAMP phosphodiesterase activity were studied in lymphocytes of bronchial asthma patients and normal persons before and 15 min after euphylline administration in a dose of 4 mg/kg. The cAMP/cGMP ratio was significantly lowered in patients. Euphylline administration led to its significant increase. In normal persons, this ratio remained unchanged. Some patients manifested an elevated activity of cAMP phosphodiesterase. In these cases, administration of euphylline brought about a significant increase in cAMP level in lymphocytes in the presence of the lowered activity of the enzyme phosphodiesterase. In the remaining patients and in normal persons, these indicators did not significantly change. It is suggested that the mechanism of euphylline action is dependent on cAMP phosphodiesterase activity.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000097:blood*; D000628:Aminophylline / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000097:blood*
D009712:Nucleotides, Cyclic; D000628:Aminophylline; D015105:3',5'-Cyclic-AMP Phosphodiesterases
Vliianie éufillina na soderzhanie tsiklicheskikh nukleotidov i aktivnost' fosfodiésterazy tsAMF v limfotsitakh bol'nykh bronkhial'noĭ astmoĭ.