Effect of naloxone-induced opioid blockade on idiopathic detrusor instability.
The effects of opioid blockade with the potent opiate/opioid antagonist, naloxone, on detrusor function are described. In a double-blind placebo-controlled trial of 28 patients, naloxone caused an increase in detrusor instability together with an increase of detrusor pressure during filling cystometry and a decrease in maximum cystometric capacity. The significance of these findings for the etiology of idiopathic detrusor instability is discussed.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004723:Endorphins / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology; D009270:Naloxone / Q000627:therapeutic use*; D011957:Receptors, Opioid / Q000187:drug effects; D001743:Urinary Bladder / Q000503:physiopathology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000503:physiopathology
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone