Morphometric investigations into the mechanism of the compensatory hypertrophy of the rat adrenal zona fasciculata after unilateral adrenalectomy.
Compensatory hypertrophy of the remaining gland in unilaterally adrenalectomized rats was investigated by morphometric techniques. It was observed that compensatory adrenal growth occurred in both dexamethasone-treated and hypophysectomized rats, receiving maintenance doses of ACTH. However, it was only half that found in intact animals. These results support the view that activation of the hypothalamo-hypophyseal axis is not the unique mechanism underlying adrenal compensatory hypertrophy in the rat.
D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology*; D000315:Adrenalectomy; D000308:Adrenocortical Hyperfunction / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D007016:Hypophysectomy; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D051381:Rats
D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone