title: Variation in the structure of varicella-zoster virus DNA.
abstract: By analyzing the fine structure of varicella-zoster virus (VZV) DNA, a naturally occurring heterogeneity was found on the right end of VZV DNA, but no evidence of a true terminal repetition was uncovered. We were unable to confirm the report of Straus and co-workers (1981) that there is a relatively high frequency of circular VZV DNA in low-passage virus. On long-term cell passage, extensive heterogeneity appeared concomitant with the accumulation of apparently defective VZV DNA.
mesh_terms: D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes; D004270:DNA, Circular / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics*; D014645:Herpesvirus 3, Human / Q000235:genetics*; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004270:DNA, Circular; D004279:DNA, Viral; D004262:DNA Restriction Enzymes