[Pharmacological aspects of digoxin complex formation with calcium and magnesium cations].
NMR spectroscopy was used to establish the formation of digoxin and digitoxin complexes with calcium ions. Microcolorimetric titration demonstrated the formation of two types of digoxin complexes with magnesium at a ratio of 1:1 and 1:2. It was noticed in rat experiments that digoxin (2.5 mg/kg) raises the magnesium level in liver tissue, whereas in a toxic dose of 12.5 mg/kg it increases the calcium content in the heart muscle.
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology*; D002412:Cations / Q000494:pharmacology; D004077:Digoxin / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008274:Magnesium / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011522:Protons; D051381:Rats; D013053:Spectrophotometry; D013816:Thermodynamics
D002412:Cations; D011522:Protons; D004077:Digoxin; D008274:Magnesium; D002118:Calcium
Farmakologicheskie aspekty kompleksoobrazovaniia digoksina s kationami kal'tsiia i magniia.