[Genetic factors in gestational trophoblastic tumors].
Gestational trophoblastic tumours group together the complete hydatidiform mole (classical) and partial mole (with fetus), invasive mole and choriocarcinoma. Genetically, trophoblastic tumours can arise in different ways: they can derive from normal zygotes with the maternal and paternal haplotype (normal pregnancy), or from a triploid zygote (partial mole) or from an XX zygote possessing only a duplicated male haplotype and no maternal contribution (complete mole). The low malignancy rate in partial mole (2.4%) compared to the complete mole (10 to 20%) remains unknown. Further analysis of the genetics of these tumours may well contribute to the understanding of the process of carcinogenesis.
D002822:Choriocarcinoma / Q000235:genetics; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000145:classification / Q000235:genetics; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics*; D015053:Zygote
Les facteurs génétiques dans les tumeurs trophoblastiques gestationnelles.