Protective effect of cAMP on tumor promoter-mediated inhibition of cell-cell communication.
The formation and maintenance of electrical cell coupling is inhibited by 100 ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA). This inhibition could be prevented by db-cAMP and aminophylline when added together with TPA, though they did not restore the cell coupling once it had already been blocked by TPA. It is suggested that db-cAMP affects the early membrane effects of TPA in FL cells.
D000628:Aminophylline / Q000494:pharmacology; D000650:Amnion; D003994:Bucladesine / Q000494:pharmacology*; D002450:Cell Communication / Q000187:drug effects*; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D010704:Phorbols; D000628:Aminophylline; D003994:Bucladesine; D013755:Tetradecanoylphorbol Acetate