Specific antagonism of the glutamate receptor by an extract from the venom of the spider Araneus ventricosus.
A venom sac extract selectively and irreversibly suppressed excitatory postsynaptic potentials in the lobster neuromuscular junction without affecting inhibitory postsynaptic potentials. Glutamate-induced depolarization of the postsynaptic membrane was blocked by the venom extract, whereas membrane depolarization by aspartate was unaffected.
D000818:Animals; D001180:Arthropod Venoms / Q000633:toxicity*; D008121:Nephropidae; D009469:Neuromuscular Junction / Q000187:drug effects*; D011956:Receptors, Cell Surface / Q000187:drug effects*; D017470:Receptors, Glutamate; D013111:Spider Venoms / Q000633:toxicity*
D001180:Arthropod Venoms; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate; D013111:Spider Venoms