title: Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and allogeneic cells.
abstract: Histamine added to murine spleen cells suppressed in vitro proliferation of lymphocytes induced by PHA or allogeneic spleen cells. Another vasoactive amine, serotonin (5-hydroxytryptamine), exerted a similar inhibitory activity on PHA- or allogeneic cell-induced lymphocyte proliferation. Anti-H2 histamine antagonists, cimetidine, metiamide, and ranitidine, blocked the histamine and serotonin suppressive effect. Cyproheptadine, an anti-H1 histamine and anti-serotonin antagonist, and methysergide, an anti-serotonin antagonist, also blocked histamine and serotonin inhibitory activities. These data suggest the presence, on lymphocytes, of receptors for serotonin which might be related to histamine receptors.
mesh_terms: D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D017259:Dimaprit; D004336:Drug Antagonism; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008785:Metiamide / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology*; D013890:Thiourea / Q000494:pharmacology
chemical_list: D010835:Phytohemagglutinins; D012701:Serotonin; D008785:Metiamide; D002927:Cimetidine; D006632:Histamine; D011899:Ranitidine; D013890:Thiourea; D017259:Dimaprit