New streptothricin-group antibiotics, AN-201 I and II. Screening, fermentation, isolation, structure and biological activity.
Two streptothricin-group antibiotics, AN-201 I and II, were newly discovered and isolated from the culture broth of Streptomyces nojiriensis C-13. These antibiotics were purified by IRC-50 (H+) and CM-Sephadex C-50 chromatography, and paper electrophoresis. Structural analysis of AN-201 I and II showed that they were N beta-acetylated derivatives of streptothricin E and D, respectively. They had antibacterial activities against several strains of Escherichia coli, Bacillus subtilis, Micrococcus luteus and Staphylococcus aureus, and showed a strong selective cytotoxic effect on 3T3 cells transformed with SV-40 as compared with their normal cells in a test system in vitro as well as in vivo.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013539:Simian virus 40 / Q000235:genetics; D013302:Streptomyces / Q000254:growth & development*; D013309:Streptothricins / Q000302:isolation & purification / Q000633:toxicity*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C040319:N-beta-acetylstreptothricin E; D013309:Streptothricins; C040320:N-beta-acetylstreptothricin D