title: [Enzymatic debridement in venous ulcus cruris. Report of a multicenter clinical comparative study with various enzyme preparations].
abstract: In a multicenter trial (comprising 258 patients in eight centers) three topical preparations for enzymatic debridement, which are widely used in our country, have been compared in the treatment of leg ulcers. Preparation A is a combination of bovine fibrinolysin and desoxyribonuclease (but without antibiotic); preparation B is a combination of clostridiopeptidase and chloramphenicol and preparation C of trypsin and framycetin sulphate. The results showed no significant difference in the effects of treatment between the preparation. Preparation A however was much better tolerated; preparation B and C induced a lot of side effects. This means that antibiotics in preparations for enzymatic debridement are not of real advantage.
mesh_terms: D002701:Chloramphenicol / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003646:Debridement / Q000379:methods*; D003851:Deoxyribonucleases / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D057487:Enzyme Therapy; D005341:Fibrinolysin / Q000627:therapeutic use; D005601:Framycetin / Q000627:therapeutic use; D006801:Humans; D003012:Microbial Collagenase / Q000627:therapeutic use; D014357:Trypsin / Q000627:therapeutic use; D014647:Varicose Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004338:Drug Combinations; C021490:deoxyribonuclease, plasmin drug combination; D005601:Framycetin; D002701:Chloramphenicol; D003851:Deoxyribonucleases; D014357:Trypsin; D005341:Fibrinolysin; D003012:Microbial Collagenase
vernacular_title: Enzymatische Wundreinigung beim venösen Ulcus cruris. Bericht über eine multizentrische klinische Vergleichsstudie mit verschiedenen Enzympräparaten.