[In vivo antibacterial activity of cefoperazone in intraperitoneal infections in mice].
The in vivo antibacterial activity of cefoperazone (CPZ) against systemic infections was studied in comparison with that of cefotiam (CTM) using beta-lactamase non-producing bacteria and producing bacteria. In vitro antibacterial activity of CPZ against Gram-positive bacteria was slightly inferior to that of CTM, but there was no significant difference between their in vivo activities. On the other hand, the therapeutic effect of CPZ against Gram-negative bacteria was nearly parallel to in vitro antibacterial activity and particularly was superior to that of CTM against cephalosporinase (CSase) producing bacteria. The ascitic levels of CPZ in mice infected with CSase producing bacteria were persisted longer, but those of CTM disappeared quickly after administration. This result appeared to reflect on the therapeutic effects of both drugs.
D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism / Q000382:microbiology; D001419:Bacteria / Q000201:enzymology; D002438:Cefoperazone / Q000378:metabolism / Q000627:therapeutic use*; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000627:therapeutic use; D015310:Cefotiam; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D010538:Peritonitis / Q000188:drug therapy* / Q000382:microbiology; D001618:beta-Lactamases / Q000096:biosynthesis
D002438:Cefoperazone; D015310:Cefotiam; D001618:beta-Lactamases; D002439:Cefotaxime