Prostaglandins fail to elevate cyclic AMP levels in mouse epidermis in vivo and in vitro.
Prostaglandin E1 had no effect on mouse epidermal cyclic AMP levels either when applied percutaneously to shaven skin or when incubated in vitro with epidermal homogenates. Neither prostaglandin E1 nor E2 had any effect on cyclic AMP levels in a line of cultured mouse epidermal cells at doses from 0.1-10 microM.
D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000032:analysis*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D011453:Prostaglandins / Q000494:pharmacology*; D012867:Skin / Q000032:analysis / Q000187:drug effects*
D011453:Prostaglandins; D000242:Cyclic AMP