Plasmid-mediated tetracycline resistance in Haemophilus ducreyi.
Clinical isolates of Haemophilus ducreyi were shown to be resistant to tetracycline. Resistance was associated in some strains with a 30-megadalton plasmid capable of transferring resistance in conjugative matings with other strains of H. ducreyi and other species of Haemophilus. Restriction endonuclease digestion patterns suggest a relationship between H. ducreyi plasmids and other tetracycline resistance plasmids in Haemophilus. The presence of plasmid-mediated resistance to the tetracyclines limits the use of these agents for the treatment of chancroid.
D003227:Conjugation, Genetic; D004262:DNA Restriction Enzymes; D004269:DNA, Bacterial / Q000032:analysis; D006191:Haemophilus ducreyi / Q000187:drug effects* / Q000235:genetics; D006868:Hydrolysis; D010641:Phenotype; D011815:R Factors; D013752:Tetracycline / Q000494:pharmacology*
D004269:DNA, Bacterial; D004262:DNA Restriction Enzymes; D013752:Tetracycline