title: Rotavirus inactivation by chemical disinfectants and antiseptics used in hospitals.
abstract: Nosocomial outbreaks of rotaviral gastroenteritis are a common occurrence. Although proper disinfection practices in the hospital environment are considered to be important in the prevention and control of such outbreaks, very little information has been available on the rotavirus-inactivating capacity of chemical disinfectants and antiseptics commonly used in hospitals. In view of this, 11 such products were selected and screened for their capacity to bring about at least a 3 log10 reduction in the plaque titre of rotavirus SA-11 after a contact time of 1-30 min. Consept "D" (1:100), D.R.X. (1:80), Dustbane Germicidal (1:80), Hibitane, and Wescodyne (1:200) were found to be ineffective under these test conditions even in the absence of an added organic load. The virucidal capacity of Savlon (1:200) and Zephiran was completely neutralized when single-strength tryptose phosphate broth was added to the virus-disinfectant mixture to simulate an organic load. Cidex (2% acid glutaraldehyde), Proviodine (10% solution of povidone-iodine), Septisol (0.75% hexachlorophene), and Sana Rinse (70% isopropylalcohol, 0.1% hexachlorophene) were able to produce at least a 3 log10 (99.9%) reduction in the virus plaque titre even in the presence of added organic matter. These findings should be of help in the prevention and control of outbreaks of rotaviral diarrhea in the hospital environment.
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology; D003428:Cross Infection / Q000517:prevention & control*; D004202:Disinfectants / Q000494:pharmacology*; D006801:Humans; D012401:Rotavirus / Q000187:drug effects*; D012400:Rotavirus Infections / Q000517:prevention & control*
chemical_list: D000891:Anti-Infective Agents, Local; D004202:Disinfectants