[The sodium-potassium pump in hypertension. Mechanisms of action of potassium].
Increasing evidence indicates that sodium ingestion in the face of an inability to excrete it normally causes hypertension by releasing a humoral pressor substance. This substance, which is probably the putative natriuretic hormone, inhibits Na+-K+-ATPase and thereby increases cardiac contractility and blood vessel tone. Potassium may be antihypertensive in part by virtue of its ability to stimulate Na+-K+-ATPase in the vascular smooth muscle cells and in adrenergic nerve endings, thereby causing vasodilation.
D000818:Animals; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D045283:Natriuretic Agents; D011188:Potassium / Q000378:metabolism* / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D007473:Ion Channels; D045283:Natriuretic Agents; D011506:Proteins; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
La pompe à sodium-potassium dans l'hypertension. Les mécanismes d'action du potassium.