title: The terminal nucleotides of retrovirus DNA are required for integration but not virus production.
abstract: Deletion of specific nucleotides at either end of the long terminal repeat of the avian retrovirus, spleen necrosis virus, results in replication-competent but integration-defective virus. This result supports two conclusions: (1) the 5-base pair terminal inverted repeats and three to seven adjacent nucleotides are required for integration; (2) integration of retrovirus DNA is not required for retrovirus gene expression.
mesh_terms: D002467:Cell Nucleus / Q000502:physiology; D002472:Cell Transformation, Viral; D002872:Chromosome Deletion; D003593:Cytoplasm / Q000502:physiology; D004251:DNA Transposable Elements; D004279:DNA, Viral / Q000235:genetics*; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics*; D014779:Virus Replication
chemical_list: D004251:DNA Transposable Elements; D004279:DNA, Viral