title: Urinary nucleic acid breakdown products as markers for trophoblastic diseases.
abstract: A feasibility study on the use of urinary nucleoside markers for the management of trophoblastic disease is presented. The markers return to normal rapidly after effective therapy, whereas the human chorionic gonadotropin levels remain elevated longer before reaching normal. If this finding is valid in a larger number of patients, it may spare patients with trophoblastic disease needless continuation of chemotherapy.
mesh_terms: D001835:Body Weight; D006063:Chorionic Gonadotropin / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D009696:Nucleic Acids / Q000378:metabolism / Q000652:urine*; D009705:Nucleosides / Q000652:urine; D011247:Pregnancy; D012343:RNA, Transfer / Q000378:metabolism; D013997:Time Factors; D014328:Trophoblastic Neoplasms / Q000175:diagnosis*; D014594:Uterine Neoplasms / Q000175:diagnosis*
chemical_list: D006063:Chorionic Gonadotropin; D009696:Nucleic Acids; D009705:Nucleosides; D012343:RNA, Transfer; D003404:Creatinine