beta-Adrenergic receptors in brain microvessels of diabetic rats.
A significant decrease in the number of beta-adrenergic receptors was observed in cerebral microvessels of fatty (fa/fa) and streptozotocin-induced diabetic rats, without receptor affinity changes. These results suggest that alterations of central adrenergic regulation of small vessels may be involved in brain microvasculature disturbances that occur with diabetes.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000098:blood supply*; D002196:Capillaries / Q000032:analysis; D002560:Cerebrovascular Circulation; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D011924:Rats, Zucker; D011943:Receptors, Adrenergic, beta / Q000032:analysis*
D001786:Blood Glucose; D011943:Receptors, Adrenergic, beta