Cholinergic transmission in vas deferens.
Prazosin, haloperidol, propranolol or timolol had no effect on the electrically evoked muscular twitch. Atropine was able to antagonize competitively acetylcholine (pA2 = 9.29 +/- 0.30). The muscular twitch of the Octodon degus vas deferens was only partially abolished by atropine (53.2 +/- 0.72). The present results can be interpreted assuming that the Octodon degus vas deferens has one component muscarinic in its innervation.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004594:Electrophysiology; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology*; D009388:Neostigmine / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D012377:Rodentia / Q000502:physiology*; D009435:Synaptic Transmission; D014649:Vas Deferens / Q000294:innervation*
D009388:Neostigmine; D001285:Atropine; D000109:Acetylcholine