[Effect of thallium ions on sodium and potassium transport in frog skin].
It has been shown that Tl+ accumulated in the frog skin cells (Rana temporaria) inhibits irreversibly the unidirectional transport of Na+ estimated by the short circuit current (SCC). The inhibiting effect of Tl+ cannot be attributed to a decrease of Na+ penetration through the apical membranes. The influx of 22Na+ from mucosal bathing solution into the skin poisoned with Tl+ was about 50% of that observed in the intact skin, while the SCC was completely inhibited. The activity of the ouabain-sensitive Na+/K+ pumps located in the basolateral cell membranes was estimated by studying the uptake of 86Rb+ as a tracer for K+. This activity was high enough to maintain the ion composition of epithelial cells in spite of their ability to accomplish the undirectional transport of Na+. Tl+ seems to inhibit the production of respiration energy utilized in the undirectional Na+ transport, while the ion homeostasis of epithelial cells may be supported by the Na+/K+ pumps consuming energy of glycolytic reactions.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D003864:Depression, Chemical; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D011896:Rana temporaria; D012413:Rubidium / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D013793:Thallium / Q000633:toxicity*
D007473:Ion Channels; D012964:Sodium; D013793:Thallium; D012413:Rubidium; D011188:Potassium
Vliianie ionov talliia na transport natriia i kaliia v kozhe liagushki.