Human papillomavirus infection of the lower female genital tract: association with multicentric neoplasia.
Fifty-four patients with multiple condylomatous lesions and/or multicentric neoplasia were identified in a consecutive series of 2,627 colposcopic examinations (2%). Forty-one percent presented with condylomata only and 57% exhibited associated intraepithelial or invasive neoplasia in at least one site. Only one patient was found to have multicentric neoplasia with no condylomatous features. There was a significant increase in mean age between patients presenting with multiple condylomatous lesions and those who had intraepithelial neoplasia as well. An association with pregnancy was found in 17% of the cases, and with renal transplant in 5%. Virus particles compatible with human papillomavirus were found in 62% of the cases examined. Evidence for a causative role in the development of neoplasia of the lower female genital tract is considered.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001706:Biopsy; D005260:Female; D005831:Genital Diseases, Female / Q000473:pathology*; D005833:Genital Neoplasms, Female / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local; D027383:Papillomaviridae / Q000302:isolation & purification; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D014412:Tumor Virus Infections; D002583:Uterine Cervical Neoplasms / Q000209:etiology; D014625:Vaginal Neoplasms / Q000209:etiology; D014846:Vulvar Neoplasms / Q000209:etiology