title: Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour.
abstract: Evidence that recessive cellular alleles at specific chromosomal loci are involved in tumorigenesis has been recently shown by work on tissues from patients with retinoblastoma, a neoplasm of embryonic retina whose predisposition is inherited as an autosomal dominant trait. A comparison of germ-line and tumour genotypes at loci on human chromosome 13, defined by restriction fragment length polymorphisms, showed that loss of the chromosome bearing the wild-type allele at the Rb-1 locus occurred frequently in the development of retinoblastoma. We report here results of similar studies of another embryonal neoplasm, Wilms' tumour of the kidney. Examination of germ-line and tumour genotypes from seven patients showed that five cases were consistent with the presence on human chromosome 11 of a locus in which recessive mutational events are expressed after abnormal chromosomal segregation events during mitosis.
mesh_terms: D000483:Alleles; D002906:Chromosomes, Human, 6-12 and X; D004262:DNA Restriction Enzymes; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D006580:Genetic Carrier Screening; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D009154:Mutation; D009396:Wilms Tumor / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D004262:DNA Restriction Enzymes