The effect of kininase II inhibitors on the response of feline cerebral arteries to bradykinin and angiotensin.
Bradykinin (BK) produced concentration-related relaxations of cat middle cerebral arteries and was ineffective on cat basilar arteries in vitro under resting tension and when contracted with 5-hydroxy-tryptamine (5-HT). Angiotensin I and II (AI, AII) produced concentration-related contraction on both arteries, AII being approximately 10 times more potent than AI. The angiotensin-converting-enzyme inhibitors, SQ, 14225, BPP5a and BPP9a had no effect on the concentration effect curves to BK, AII or 5-HT but responses to AI were inhibited. These results suggest that angiotensin-converting-enzyme is present in both preparations and is important for the conversion of AI to AII but apparently not for the degradation of BK.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques
D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins; D004791:Enzyme Inhibitors; D001920:Bradykinin