Potassium channels moderate ectopic excitability of nerve-end neuromas in rats.
The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas.
D015761:4-Aminopyridine; D000344:Afferent Pathways / Q000503:physiopathology; D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D001369:Axons / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects; D007473:Ion Channels / Q000502:physiology*; D008297:Male; D009115:Muridae; D009416:Nerve Regeneration / Q000187:drug effects; D009463:Neuroma / Q000503:physiopathology*; D011188:Potassium / Q000378:metabolism; D012584:Sciatic Nerve / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D013979:Tibial Nerve / Q000503:physiopathology
D000631:Aminopyridines; D007473:Ion Channels; D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium; D015761:4-Aminopyridine; D011188:Potassium