Antiviral and antiproliferative activities of three molecular components of leukocyte-derived human interferon.
Antiviral and antiproliferative activities of three naturally occurring components of leukocyte-derived human interferon (HuIFN-alpha) separated by concanavalin A-agarose affinity chromatography were studied in a variety of neoplastic cell lines. Significant differences were seen with these different components. The results strongly suggest that careful consideration must be given while selecting any one component of HuIFN-alpha for any of the antiviral or antiproliferative studies. There is no clear evidence that glycosylation of HuIFN-alpha has any significant influence on its in vitro antiviral or antiproliferative activities, although apparently glycosylated and non-glycosylated components gave different antiviral and antiproliferative responses in different tumor cells.
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007370:Interferon Type I / Q000302:isolation & purification* / Q000494:pharmacology; D008970:Molecular Weight; D009369:Neoplasms / Q000188:drug therapy; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D007370:Interferon Type I