title: Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2.
abstract: Two distinct isozymes (UMPH-1 and UMPH-2) which hydrolyse pyrimidine 5'-nucleotides have been identified in mouse, rat and Chinese hamster tissues. One of these, UMPH-1 appears to be specific for pyrimidine 5'-nucleotides, whereas the other, UMPH-2 has a broader substrate specificity. UMPH-1 and UMPH-2 show differences in their expression in different tissues. The evidence suggests that UMPH-1 and UMPH-2 are coded by distinct structural gene loci, Umph-1 and Umph-2. These isozymes have not been identified in man, and it is suggested that they may have overlapping electrophoretic mobility.
mesh_terms: D015720:5'-Nucleotidase; D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D004592:Electrophoresis, Starch Gel; D005796:Genes; D006801:Humans; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009708:Nucleotidases / Q000235:genetics* / Q000378:metabolism; D011742:Pyrimidine Nucleotides; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity; D014018:Tissue Distribution
chemical_list: D007527:Isoenzymes; D011742:Pyrimidine Nucleotides; D009708:Nucleotidases; D015720:5'-Nucleotidase