Lithium and the prevention of dopamine receptor supersensitivity in diabetic rats.
Dopamine receptors were increased in rats made diabetic by alloxan; however, chronic lithium treatment substantially reduced the number of dopamine receptors. These findings may be relevant to the effects of lithium in psychiatric disorders.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002712:Chlorides / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism
D001786:Blood Glucose; D002712:Chlorides; D011954:Receptors, Dopamine; D013134:Spiperone; D008094:Lithium; D018021:Lithium Chloride