Hemagglutination by human rotavirus strains.
Human rotavirus isolates, KUN , MO, and Wa strains were found to agglutinate erythrocytes of the day-old chicken and adult goose, optimally at pH 6.6. Only those fractions containing double-shelled rotavirus particles isolated by isopycnic centrifugation in cesium chloride had hemagglutinating activity. Trypsin treatment decreased the hemagglutination titer of human rotavirus strains and conversely increased their infectivity. Hemagglutination inhibition tests with antisera against type-specific antigens demonstrable by neutralization showed no type specificity.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002460:Cell Line; D004622:Embryo, Mammalian; D005455:Fluorescent Antibody Technique; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006387:Hemagglutination, Viral; D006801:Humans; D008253:Macaca mulatta; D012401:Rotavirus / Q000254:growth & development / Q000276:immunology*; D014779:Virus Replication
D000914:Antibodies, Viral