beta-adrenergic receptor sensitivity in cultured vascular smooth muscle cells: effect of age and of dietary restriction.
The effect of age and of dietary restriction on vascular beta-receptor sensitivity was investigated using cultured smooth muscle cells from rat aortas. The growth rate was slower in cells obtained from 36-month-old rats than in cells obtained from 24-month-old rats and the cells from older animals achieved lower densities. The dietary restriction did not affect growth of cells from 24-month-old rats but increased cell numbers in 36-month-old rats. The elevation of the cyclic AMP level in response to epinephrine was decreased with age. Cells from dietary restricted animals responded more to epinephrine than cells from animals of the same age fed ad libitum.
D000375:Aging; D000818:Animals; D001011:Aorta; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000096:biosynthesis; D004032:Diet; D004837:Epinephrine / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013268:Stimulation, Chemical
D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D004837:Epinephrine