Growth stimulation of human breast cancer MCF-7 cells by dibutyryl cyclic AMP.
Dibutyryl cAMP significantly stimulated cell proliferation of human mammary MCF-7 cells in estradiol-deficient medium. In the presence of estradiol (which strongly stimulated MCF-7 cell growth), dbcAMP had only slight additional stimulatory effects. At very high concentrations (1 mM), dbcAMP inhibited cell proliferation in the presence of estradiol and stimulation was less effective without estradiol. The actions of high dbcAMP concentrations are probably caused by the butyrate component of dbcAMP. It is concluded that dbcAMP is a growth-promoting agent for MCF-7 cells.
D001943:Breast Neoplasms / Q000473:pathology*; D003994:Bucladesine / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005576:Colforsin; D004224:Diterpenes / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans
D004224:Diterpenes; D005576:Colforsin; D004958:Estradiol; D003994:Bucladesine