title: The effect of cyclic AMP on the rabbit corneal endothelial fluid pump.
abstract: Perfusing preswollen deepithelialized rabbit cornea in vitro on its endothelial side with balanced salt solution containing physiological glucose concentration and 10(-6)M adenosine, we can obtain "temperature reversal" from 500-520 microns to less than 400 microns, during 7 hours. Low concentrations of adenosine improve the fluid pump supposedly by inhibiting adenylate cyclase, since c-AMP inhibits the pump.
mesh_terms: D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000502:physiology; D000242:Cyclic AMP / Q000494:pharmacology*; D004727:Endothelium / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D011817:Rabbits; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D000242:Cyclic AMP