Hyperglycemic effect in the rabbit induced by ACTH4-10.
In the rabbit, a single i.v. administration of ACTH4-10 (130 micrograms/kg) induces hyperglycemia. As ACTH4-10 also induces hypocalcemia and inhibits insulin secretion, we suggest that hypocalcemia, inhibition of insulin secretion, and hyperglycemia, are closely related.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D006943:Hyperglycemia / Q000139:chemically induced*; D007328:Insulin / Q000097:blood*; D007700:Kinetics; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10); D002118:Calcium