A comparison of the combination pivmecillinam/pivampicillin and co-trimoxazole in the treatment of convalescent carriers of Salmonella and Shigella.
52 convalescent carriers of Salmonellae (n = 25) and Shigellae (n = 27) were treated with a 4-week course of either co-trimoxazole or the combination pivmecillinam/pivampicillin. 84% of the salmonella isolates and 89% of the shigella were resistant to one or more antibiotics. Sulphonamide resistance was observed in 52 and 58% of the strains, respectively. 12 and 44% of the isolates, respectively, were resistant to ampicillin. All were sensitive to mecillinam and all except 2 were sensitive to co-trimoxazole. In salmonella carriers, co-trimoxazole was successful in 54% of the subjects and pivmecillinam/pivampicillin in 58%. Co-trimoxazole cured 83% of the shigella carriers and pivmecillinam/pivampicillin 87%. Shigella carriers responded to therapy promptly. Concurrent biliary disease or diverticulosis adversely affected the prognosis in salmonella carriers.
D000328:Adult; D000561:Amdinocillin Pivoxil / Q000008:administration & dosage*; D000667:Ampicillin / Q000031:analogs & derivatives*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002353:Carrier State / Q000188:drug therapy*; D002675:Child, Preschool; D004338:Drug Combinations / Q000008:administration & dosage; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010397:Penicillanic Acid / Q000008:administration & dosage*; D010403:Penicillin Resistance; D010917:Pivampicillin / Q000008:administration & dosage*; D012475:Salmonella / Q000187:drug effects; D012480:Salmonella Infections / Q000188:drug therapy*; D012760:Shigella / Q000187:drug effects; D013420:Sulfamethoxazole / Q000008:administration & dosage*; D014295:Trimethoprim / Q000008:administration & dosage*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D010917:Pivampicillin; D000561:Amdinocillin Pivoxil; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D010397:Penicillanic Acid; D014295:Trimethoprim; D013420:Sulfamethoxazole