Autoradiographic localization of substance P receptors using 125I substance P.
This paper describes a method for localization of substance P receptors in the rat central nervous system using 125I labeled substance P in an autoradiographic procedure. Particularly high densities of substance P receptors were observed in the olfactory bulb, dentate gyrus, amygdala, superior colliculus, and locus coeruleus. Surprisingly low densities of substance P receptors were found in the substantia nigra pars reticulata, a region which contains high concentrations of substance P.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D007457:Iodine Radioisotopes; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis*; D018040:Receptors, Neurokinin-1
D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D018040:Receptors, Neurokinin-1