Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1.
Monoclonal antibodies directed against glycoprotein D of herpes simplex virus completely inhibited fusion of Vero cells infected with type 1 virus. In contrast, several monoclonal antibodies directed against other viral glycoproteins, including B, were ineffective or were only minimally inhibitory at the highest concentrations tested.
D000818:Animals; D000911:Antibodies, Monoclonal; D002459:Cell Fusion; D002460:Cell Line; D002522:Chlorocebus aethiops; D018139:Simplexvirus / Q000502:physiology*; D014760:Viral Fusion Proteins; D014764:Viral Proteins / Q000276:immunology / Q000502:physiology*
D000911:Antibodies, Monoclonal; D014760:Viral Fusion Proteins; D014764:Viral Proteins