title: The superoxide free radical: its biochemistry and pathophysiology.
abstract: The partial reduction of molecular oxygen in biologic systems produces the cytotoxic intermediates superoxide, hydrogen peroxide, and hydroxyl radical. The superoxide radical is now recognized to play significant roles in a number of pathophysiologic states including oxygen toxicity, radiation damage, phagocyte-mediated inflammation, and postischemic injury.
mesh_terms: D000818:Animals; D005609:Free Radicals; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism; D007700:Kinetics; D009504:Neutrophils / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010587:Phagocytosis; D011832:Radiation Injuries / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism* / Q000633:toxicity
chemical_list: D005609:Free Radicals; D013481:Superoxides; D010100:Oxygen