Effect of suloctidil on dopaminergic transmission in various rat brain areas: possible uses as drug for the elderly.
Suloctidil is a drug used in the elderly endowed with a mechanism of action at neuronal level which has not been completely explored. The results of the present study indicate that acute treatment with suloctidil induces a decrease of serum prolactin levels and a decrease of 3,4-diidroxyphenylacetic acid concentrations in various rat brain areas. In addition, the repeated injection of small Suloctidil doses produces a down-regulation of dopaminergic receptors. These data suggest that Suloctidil has dopamino-mimetic properties in vivo. This pharmacological activity may be of importance in the clinical action of Suloctidil in the elderly.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000375:Aging; D000818:Animals; D001921:Brain / Q000187:drug effects*; D008297:Male; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013468:Suloctidil / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D011412:Propanolamines; D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D013468:Suloctidil