Effect of medroxyprogesterone and an aorta-derived cell growth inhibitor on B16 melanoma in mice.
An aorta-derived inhibitor of endothelial cell and tumor cell growth and medroxyprogesterone, which depresses collagenase expression in vivo, were tested alone and in combination against B16-F10 melanoma in C57BL/6 mice in such doses that either agent alone had little effect. Together, these agents retarded growth of subcutaneously transplanted tumor cells and reduced the number and size of pulmonary tumors after iv tumor cell injection. Of the treatments used, only the aortic factor administered alone prolonged life in mice with pulmonary tumors.
D000818:Animals; D001011:Aorta; D002460:Cell Line; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D006131:Growth Inhibitors / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D051379:Mice; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors; D009368:Neoplasm Transplantation; D013997:Time Factors; D014020:Tissue Extracts / Q000627:therapeutic use
D006131:Growth Inhibitors; D014020:Tissue Extracts; D003012:Microbial Collagenase; D008525:Medroxyprogesterone