[Dopamine modification of the Ca-component of the action potential in the neuron soma of the mollusk L. stagnalis].
Dopamine has been found to decrease reversibly the action potential rising phase in identified L. stagnalis neurones. Using voltage-clamp and intracellular dialysis techniques it is shown that dopamine inhibits electroexcitable Ca-current, and changes in Ca-current determine those in the action potential shape. Serotonin and adrenaline influence the Ca-current in a similar way as dopamine does. Inhibition of Ca-conductance is found not to be related to possible effect of these neuromediators on intracellular level of free Ca ions or cyclic AMP.
D000200:Action Potentials; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000378:metabolism*; D008195:Lymnaea / Q000502:physiology*; D008564:Membrane Potentials; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D013997:Time Factors
D007473:Ion Channels; D012701:Serotonin; D004298:Dopamine
Moduliatsiia dofaminom Ca-komponenty potentsiala deĭstviia v some neĭronov molliuska L. stagnalis.