Evidence for an intramuscular depot of the cholinesterase inhibitor soman in the rat.
Isolated rat diaphragms were treated with the oxime HI-6, 25 min after the start of soman exposure for 5, 15, 20 or 25 min. Recovery of neuromuscular transmission (NMT) was smaller and the subsequent spontaneous failure of NMT greater when soman exposure was longer. Diaphragms taken from anaesthetized atropinized soman-poisoned rats treated with HI-6 again showed spontaneous failure of NMT when tested repeatedly in vitro. In vivo pretreatment with a soman simulator prevented reinhibition in vitro. The results are indicative of a simulator-sensitive soman depot in muscles.
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000378:metabolism; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D003964:Diaphragm / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010091:Oximes; D011726:Pyridinium Compounds / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012999:Soman / Q000378:metabolism* / Q000506:poisoning; D009435:Synaptic Transmission / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; D012999:Soman; C022870:asoxime chloride