title: Naloxone.
abstract: Naloxone hydrochloride, a synthetic N-allyl derivative of oxymorphone, is an effective agent for the reversal of the cardiovascular and respiratory depression associated with narcotic and possibly some non-narcotic overdoses. It is essentially a pure narcotic antagonist, is relatively safe, and is a useful diagnostic and therapeutic agent. Due to naloxone's pharmacokinetic profile, a continuous infusion protocol is recommended when prolonged narcotic antagonist effects are required. The complex pharmacodynamics of naloxone, specifically relating to endorphin receptor sites, focus its potential use in a variety of clinical situations as continuing research illustrates the association of endogenous opioid compounds with various disease states.
mesh_terms: D000328:Adult; D000818:Animals; D004630:Emergencies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D009292:Narcotic Antagonists; D009294:Narcotics / Q000506:poisoning; D011957:Receptors, Opioid / Q000187:drug effects; D012131:Respiratory Insufficiency / Q000188:drug therapy
chemical_list: D009292:Narcotic Antagonists; D009294:Narcotics; D011957:Receptors, Opioid; D009270:Naloxone