Teleocidin is not mitogenic for 12-O-tetradecanoylphorbol-13-acetate non-proliferative variants of 3T3 cells.
Teleocidin and 12-O-tetradecanoylphorbol-acetate (TPA), two potent tumor promoters, are also excellent mitogens for 3T3 cells. I now demonstrate that teleocidin is unable to stimulate mitogenesis in TPA non-proliferative 3T3 variants that retain TPA receptors.
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors; D014644:Genetic Variation; D008235:Lyngbya Toxins; D051379:Mice; D010704:Phorbols / Q000633:toxicity*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D000470:Alkaloids; D002273:Carcinogens; D008235:Lyngbya Toxins; D010704:Phorbols; D011956:Receptors, Cell Surface; C022176:teleocidins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D013755:Tetradecanoylphorbol Acetate