Protective immunization of mice with specific HSV-1 glycoproteins.
Two herpes simplex virus type 1 (HSV-1) antigens of apparent molecular weight 123,000 and 63,000 which are associated with the viral glycoprotein complex have been identified and purified using virus-specific monoclonal antibodies. Mice immunized with either glycoprotein showed marked resistance to challenge with virulent HSV-1. Therefore purified glycoproteins of HSV-1 free of nucleic acid can be used in protective immunization of mice against human herpes simplex type 1.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology* / Q000302:isolation & purification; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000276:immunology* / Q000302:isolation & purification; D006561:Herpes Simplex / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010446:Peptide Fragments / Q000032:analysis; D011863:Radioimmunoassay; D018139:Simplexvirus / Q000276:immunology*; D014611:Vaccination; D014764:Viral Proteins / Q000276:immunology / Q000302:isolation & purification
D000956:Antigens, Viral; D006023:Glycoproteins; D010446:Peptide Fragments; D014764:Viral Proteins