Metabolism of phenanthridine to phenanthridone by rat lung and liver microsomes after induction with benzo[a]pyrene and Aroclor.
The comparative metabolism of phenanthridine (3,4-benzoquinoline) by rat lung and liver microsomes has been investigated. The array of metabolites produced by induced lung and liver are qualitatively similar. Phenanthridone has been identified as a phenanthridine metabolite produced by induced rat liver and lung. Phenanthridone is directly mutagenic in Salmonella tester strain TA-98 while phenanthridine is not. Although phenanthridone is more mutagenic than phenanthridine after incubation with rat liver 9000g supernatant fraction, it is less cytotoxic to Chinese hamster ovary cells in vitro.
D000818:Animals; D001140:Aroclors / Q000494:pharmacology*; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000494:pharmacology*; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D009153:Mutagens; D010617:Phenanthridines / Q000378:metabolism* / Q000633:toxicity; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D001140:Aroclors; D001580:Benzopyrenes; D002273:Carcinogens; D009153:Mutagens; D010617:Phenanthridines; D001564:Benzo(a)pyrene; D011078:Polychlorinated Biphenyls