[Opiate activity of a bone marrow humoral factor which stimulates antibody production].
The radioceptor method was used to demonstrate that humoral factor of the bone marrow, a stimulant of antibody production (SAP), contains substances that competitively remove 3H-morphine and 3H-met-enkephalin from opiate receptors of the rat brain, and 3H-met-enkephalin from specific binding sites on human lymphocytes. Comparison of the magnitudes EC50 SAP obtained during the removal of labeled opiates allows a suggestion to be made that opiates contained by the preparation under study have a greater capability to interact with delta-type opiate receptors rather than with those of the mu-type.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001665:Binding Sites; D001667:Binding, Competitive; D001853:Bone Marrow / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000378:metabolism*; D005260:Female; D008214:Lymphocytes / Q000378:metabolism*; D009020:Morphine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000378:metabolism*
D011957:Receptors, Opioid; D004744:Enkephalin, Methionine; D009020:Morphine
Opiatnaia aktivnost' gumoral'nogo faktora kostnogo mozga, stimuliruiushchego produktsiiu antitel.