title: A hyperpolarization-activated chloride current in Xenopus laevis oocytes under voltage-clamp.
abstract: Voltage-clamp experiments have been performed on ovulated Xenopus laevis oocytes. Two kinds of oocytes were studied: mature oocytes presenting the white spot due to germinal vesicle breakdown (GVBD) were found to be essentially unexcitable; oocytes without the white spot appeared to possess ionic channels which open transiently on hyperpolarization. The current is carried by chloride ions and, in Holtfreter's solution, has a reversal potential at approximately - 15 mV.
mesh_terms: D000818:Animals; D002712:Chlorides / Q000378:metabolism*; D004594:Electrophysiology; D005260:Female; D007473:Ion Channels / Q000502:physiology*; D009865:Oocytes / Q000502:physiology*; D014982:Xenopus laevis
chemical_list: D002712:Chlorides; D007473:Ion Channels