Neurovirulence of an herpes simplex type 1 thymidine kinase negative mutant determined by virus biochemical defect and host immune system in mice. Brief report.
While the biochemical defect of the thymidine kinase negative HSV-1 mutant restricts virus replication in mouse neural tissue, and thereby reduces neurovirulence, the host immune system also limits HSV-1 TK- replication in permissive glial cells in immunocompetent mice, and reduces neurovirulence.
D000818:Animals; D001921:Brain / Q000382:microbiology; D006561:Herpes Simplex / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D009154:Mutation; D009474:Neurons / Q000382:microbiology*; D018139:Simplexvirus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D013937:Thymidine Kinase / Q000172:deficiency*; D014779:Virus Replication
D013937:Thymidine Kinase