Neurotensin receptors in the rat striatum: lesion studies.
The specific binding of [3H]neurotensin binding to the rat striatum was characterized and its localization investigated by using frontal cortex ablations and the neurotoxins kainic acid and 6-hydroxydopamine. Scatchard analysis indicated the existence of a single population of binding sites and the potencies of various neurotensin fragments in competing with [3H]neurotensin for its binding site were in good agreement with the potency values obtained in biological assays. The lesion studies indicated that more than 50% of striatal neurotensin receptors are localized on intrinsic neurones, approximately 30% on dopaminergic nerve terminals and 20% on corticostriatal nerve fibres.
D000818:Animals; D001667:Binding, Competitive; D002421:Caudate Nucleus / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009410:Nerve Degeneration; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009496:Neurotensin / Q000378:metabolism*; D011699:Putamen / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018028:Receptors, Neurotensin
D011956:Receptors, Cell Surface; D018028:Receptors, Neurotensin; D009496:Neurotensin; D004298:Dopamine