Can blocking the Na/K exchange pump lead to a reduction in intracellular sodium?
It has been assumed that a rise in intracellular sodium should follow inhibition of the Na/K exchange pump. However, under certain conditions a reduction in intracellular sodium following pump blockage is possible. Many results postulating 'stimulation' of the Na/K exchange pump by low doses of the cardiac glycosides can be explained in this manner.
D002301:Cardiac Glycosides / Q000494:pharmacology*; D002462:Cell Membrane / Q000502:physiology; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D002301:Cardiac Glycosides; D007473:Ion Channels; D012964:Sodium; D011188:Potassium