Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin.
A plaque-reduction assay was used to examine the susceptibility of five phosphonoformic acid-resistant variants of herpes simplex virus type 1 to arabinosylnucleosides and aphidicolin. These viruses were cross-resistant to arabinosylhypoxanthine and to arabinosyladenine when tested in the absence of deoxycoformycin, a deaminase inhibitor. In the presence of deoxycoformycin, no cross-resistance between arabinosyladenine and phosphonoformic acid was observed. The two variants tested were cross-resistant to arabinosylthymine, and all five variants were collaterally susceptible to aphidicolin inhibition.
D000998:Antiviral Agents / Q000494:pharmacology*; D016590:Aphidicolin; D001087:Arabinonucleosides / Q000494:pharmacology*; D003070:Coformycin / Q000031:analogs & derivatives / Q000494:pharmacology; D004259:DNA-Directed DNA Polymerase / Q000032:analysis; D004224:Diterpenes / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D017245:Foscarnet; D015649:Pentostatin; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects*; D013936:Thymidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013937:Thymidine Kinase / Q000032:analysis; D014740:Vidarabine / Q000494:pharmacology
D000998:Antiviral Agents; D001087:Arabinonucleosides; D004224:Diterpenes; D003070:Coformycin; D017245:Foscarnet; D016590:Aphidicolin; D015649:Pentostatin; C008099:hypoxanthine arabinoside; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase; D014740:Vidarabine; D010746:Phosphonoacetic Acid; C010032:thymine arabinoside; D013936:Thymidine