Normalizing effect of an adrenocorticotropic hormone (4-9) analog ORG 2766 on disturbed social behavior in rats.
Short-term isolation increased the frequency of social interactions in rats tested in pairs, while pairs of rats placed in an unfamiliar test cage and subjected to a high level of illumination spent less time in active social contact. These changes in social behavior elicited by environmental manipulations were counteracted by treatment with the adrenocorticotropic hormone (4-9) analog ORG 2766. The peptide's normalizing effect may be mediated by endogenous opioid systems.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D004723:Endorphins / Q000502:physiology; D006801:Humans; D009271:Naltrexone / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012919:Social Behavior; D012920:Social Behavior Disorders / Q000188:drug therapy
D004723:Endorphins; D010446:Peptide Fragments; C013765:Org 2766; D009271:Naltrexone; D000324:Adrenocorticotropic Hormone