title: Neurotensin affects hyperactivity but not stereotypy induced by pre and post synaptic dopaminergic stimulation.
abstract: The effects of intraventricular administration of neurotensin (0.9, 3.75 and 15.0 micrograms) on hyperactivity and stereotypy induced by either amphetamine (1 mg/kg), nomifensine (20 mg/kg), apomorphine (0.5 mg/kg) or N-n-propylnorapomorphine (0.5 mg/kg) were examined. Results indicate that for each drug treatment, the effects of neurotensin were identical: hyperactivity was significantly reduced while stereotypy remained unaffected. Results also revealed that neurotensin significantly increased the hypothermia induced by apomorphine and N-n-propylnorapomorphine. Possible mechanisms which could underly neurotensin's selective inhibitory action on hyperactivity produced by both pre and post synaptic dopaminergic stimulation are discussed.
mesh_terms: D000661:Amphetamine / Q000008:administration & dosage; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced*; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D009627:Nomifensine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D009627:Nomifensine; D009496:Neurotensin; C009074:N-n-propylnorapomorphine; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine