Androgen modulation of adrenal angiotensin receptors.
Several polar androgens increased the binding of angiotensin and its stimulation of aldosteronogenesis in bovine adrenal glomerulosa cells. The effect was seen only if the steroids were applied to the cells and then washed away. This phenomenon and the technique for demonstrating it may have implications for studies of receptor modulation and for clinical states in which responsiveness to angiotensin is increased.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism; D000728:Androgens / Q000494:pharmacology*; D000804:Angiotensin II / Q000378:metabolism; D000805:Angiotensin III / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000494:pharmacology; D019314:Dehydroepiandrosterone Sulfate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D011945:Receptors, Angiotensin / Q000187:drug effects*; D011956:Receptors, Cell Surface / Q000187:drug effects*; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology
D000728:Androgens; D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D000804:Angiotensin II; D000805:Angiotensin III; D013739:Testosterone; D003687:Dehydroepiandrosterone; D000450:Aldosterone; C029763:testosterone-17-succinate; D019314:Dehydroepiandrosterone Sulfate