title: Radiation risk of thyroid scintigraphy in newborns.
abstract: Tumor risk factors were calculated for newborns who were investigated for congenital hypothyroidism (CHT) with radionuclides by thyroid scintigraphy. Figures for three radiopharmaceuticals, 99mTc-pertechnetate, 123I-and 131I-sodium iodide for adults were extrapolated to newborns. The radiation dose to the normal thyroid gland in newborns was seven times higher for 123I-NaI than for 99mTcO-4, the somatically effective total body dose was two times higher for 123I-NaI than for 99mTcO-4. The use of 123I-NaI was preferred because of better scintigraphic results. Risk estimates for thyroid scintigraphy in newborns in the diagnostic work-up of CHT are given using published age-dependent tumor induction figures derived from atomic bomb survivors.
mesh_terms: D003409:Congenital Hypothyroidism; D006801:Humans; D007037:Hypothyroidism / Q000000981:diagnostic imaging*; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D012306:Risk; D013670:Sodium Pertechnetate Tc 99m; D013667:Technetium / Q000009:adverse effects*; D013964:Thyroid Neoplasms / Q000209:etiology*
chemical_list: D007457:Iodine Radioisotopes; D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m