[Course of ampicillin sensitivity in Haemophilus influenzae responsible for purulent meningitis in children. Therapeutic consequences].
Bacterial meningitis caused by Haemophilus influenzae observed from 1976 to 1980 (10 cases) are compared with those observed in 1981 (9 cases). From 1976 to 1980, 9 strains (90%) are ampicillin-sensitive. In 1981, 5 strains (55,5%) are ampicillin-sensitive and 4 strains (45,5%) are ampicillin-resistant and betalactamase positive. These 9 strains are serotype b. Therefore, since 1981, initial treatment of bacterial meningitis in infancy is a new cephalosporin, in this study is cefotaxime.
D000667:Ampicillin / Q000494:pharmacology* / Q000627:therapeutic use; D002439:Cefotaxime / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D007223:Infant; D008297:Male; D008583:Meningitis, Haemophilus / Q000188:drug therapy / Q000382:microbiology*; D010403:Penicillin Resistance
D000667:Ampicillin; D002439:Cefotaxime
Evolution de la sensibilité à l'ampicilline des Haemophilus influenzae responsables de méningites purulentes chez l'enfant. Conséquences thérapeutiques.