Effect of an intraluminal food-bulk on low calorie induced hyperbilirubinaemia.
To test the hypothesis that the presence of food in the intestine plays a role in the control of serum bilirubin levels, the effect of a 1674 kJ (400 kcal) diet, including non-absorbable material able to produce an intestinal bulk, was compared with the effect of caloric restriction alone. In normal individuals (n = 10) the rise of plasma bilirubin was comparable after the two trials. In patients with Gilbert's syndrome (n = 18), bilirubin concentration rose to a much greater extent during the caloric restriction as compared with controls, and to a lesser extent (P less than 0.001) after the bulky diet, as compared with caloric restriction alone in the same patient. It is proposed that a factor originating from the intestine, perhaps a hormone, the release of which is dependent on the presence of food-bulk, plays a role in the control of hyperbilirubinaemia associated with caloric restriction.
D000328:Adult; D004032:Diet / Q000009:adverse effects*; D004043:Dietary Fiber; D002149:Energy Intake; D005260:Female; D005878:Gilbert Disease / Q000378:metabolism*; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced*; D006933:Hyperbilirubinemia, Hereditary / Q000378:metabolism*; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male