On the possible role of temporal delays of afferent processing in Parkinson's disease.
Visual evoked potential (VEP) latency is one measure of afferent delays in Parkinson's disease. New aspects of temporal processing were studied in the VEP of 7 patients and 10 normals. For this analysis the patterned stimulus was simultaneously modulated at two temporal frequencies. Phase shifts of non-linear VEP components in patients, compared to normals, revealed that an abnormality of temporal processing in this disease must be caused by altered neuronal interactions, not only by simple conduction defects.
D000328:Adult; D000368:Aged; D005074:Evoked Potentials, Visual; D006801:Humans; D008875:Middle Aged; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology*; D010364:Pattern Recognition, Visual / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D009435:Synaptic Transmission; D014793:Visual Cortex / Q000503:physiopathology*; D014795:Visual Pathways / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*