title: Macrophage activation in murine African trypanosomiasis.
abstract: African trypanosomiasis is accompanied by a profound general immunosuppression in which both suppressive T cells and macrophages (M phi) have been implicated. The present studies define changes in the M phi surface, endocytic and secretory properties, during the infection of mice by Trypanosoma brucei. Peritoneal M phi obtained after the control of the first wave of parasitemia displayed characteristics similar to those activated by intracellular pathogens, such as Mycobacterium bovis bacillus Calmette-Guérin, e.g., the enhanced expression of Ia antigen, decreased M phi-specific antigens, receptors mediating the pinocytosis of mannose-terminal glycoproteins, and an increased ability to secrete plasminogen activator, superoxide anion, and H2O2. Some markers of macrophage activation persisted during the subpatent period before the recurrence of parasitemia, whereas others reverted to normal. Mature T cell function appears not to be essential for M phi activation by T. brucei since the infection of athymic nude mice also induced Ia antigens and plasminogen activator. These studies show that M phi activated by different pathways express common features which may contribute to immune dysfunction observed in trypanosomiasis, as well as in other infections.
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006861:Hydrogen Peroxide / Q000378:metabolism; D037181:Lectins, C-Type; D008262:Macrophage Activation; D008264:Macrophages / Q000502:physiology; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D051379:Mice; D008819:Mice, Nude; D010873:Pinocytosis; D010960:Plasminogen Activators / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D011961:Receptors, Fc / Q000032:analysis; D013481:Superoxides / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000276:immunology*
chemical_list: D000954:Antigens, Surface; D000949:Histocompatibility Antigens Class II; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D011961:Receptors, Fc; D013481:Superoxides; D006861:Hydrogen Peroxide; D010960:Plasminogen Activators