title: Pancreatic secretory profiles of protein, digestive, and lysosomal enzymes in Syrian golden hamster. Effect of secretin and cholecystokinin.
abstract: Profiles of pancreatic secretory proteins (zymogens, lysosomal enzymes) were studied in Syrian golden hamsters after sequential stimulation of the pancreas with secretin and cholecystokinin-octapeptide (CCK). The flow rate of pancreatic juice after secretin (0.2 CU/100 g) was approximately 2.7 microliters/min/100 g animal (about 55% of that in human subjects). The half-life of the secretin effect was about 60 min. The initial concentration of protein in pancreatic juice (minute-to-minute collection) in response to secretin was over 10 times larger than that in human subjects and the "wash-out" phase required greater than 1 hr vs less than 10 min in humans. CCK (4 ng/100 g) in minute-to-minute collections of juice produced an approximately eightfold increase in concentration of secretory products over baseline values, and the half-life of its effect was about 2 min, similar to that found in human subjects. Digestive as well as lysosomal enzyme activities in hamster pancreatic juice were 10-15 times higher than those found in human pancreatic secretions. This species difference may be relevant to the susceptibility of the hamster pancreas to carcinogens.
mesh_terms: D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D002766:Cholecystokinin / Q000494:pharmacology*; D002918:Chymotrypsin / Q000378:metabolism; D006224:Cricetinae; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D008297:Male; D008647:Mesocricetus; D010179:Pancreas / Q000378:metabolism*; D010196:Pancreatic Elastase / Q000378:metabolism; D010189:Pancreatic Juice / Q000187:drug effects* / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D012633:Secretin / Q000494:pharmacology*; D012844:Sincalide; D014357:Trypsin / Q000378:metabolism; D014361:Trypsin Inhibitors / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; D011506:Proteins; D014361:Trypsin Inhibitors; D012633:Secretin; D002766:Cholecystokinin; D001192:Arylsulfatases; D005966:Glucuronidase; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D014357:Trypsin; D012844:Sincalide