[Effect of trihydroxyoctadecadiene acids from Bryonia alba L. on the activity of glycogen metabolism enzymes in alloxan diabetes].
It was shown previously in experiments on white rats with alloxan diabetes that trihydroxyoctadecadiene acids from Bryonia alba L. have a hypoglycemic action. The present paper is concerned with the effects of the above-indicated compounds on the activity of glycogen phosphorylase (a- and b-forms), phosphoprotein phosphatase and hexokinase in liver and muscle tissues of white rats with alloxan diabetes. One of the possible mechanisms of the hypoglycemic action of trihydroxyoctadecadiene acids is discussed.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology*; D006593:Hexokinase / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010762:Phosphorylase a / Q000378:metabolism; D010763:Phosphorylase b / Q000378:metabolism; D051381:Rats
D005231:Fatty Acids, Unsaturated; D005233:Fatty Alcohols; D007004:Hypoglycemic Agents; D010762:Phosphorylase a; D010763:Phosphorylase b; D006593:Hexokinase; D010749:Phosphoprotein Phosphatases
Vliianie trioksioktadekadienovykh kislot iz Bryonia alba L. na aktivnost' fermentov obmena glikogena pri alloksanovom diabete.