Polyglycolic acid and catgut sutures, with and without oral proteolytic enzymes, in the healing of episiotomies.
Polyglycolic acid (PGA) sutures and traditional catgut were compared in 190 patients undergoing episiotomy. Each group was also randomly allocated to a double blind comparison of therapy with oral proteolytic enzymes (Chymoral) and placebo. The combination of Chymoral and polyglycolic acid sutures was shown to reduce the level of pain, assessed subjectively, and there was a significant reduction in analgesic requirements in the Chymoral/PGA group.
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002398:Catgut; D002918:Chymotrypsin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D004841:Episiotomy / Q000009:adverse effects; D005260:Female; D006801:Humans; D010149:Postoperative Pain / Q000517:prevention & control; D011100:Polyglycolic Acid; D011247:Pregnancy; D011897:Random Allocation; D013537:Sutures; D014357:Trypsin / Q000627:therapeutic use*; D014945:Wound Healing
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D011100:Polyglycolic Acid; C007059:chymotrypsin, trypsin drug combination; D002918:Chymotrypsin; D014357:Trypsin