Modifying effect of dietary fat on benzo[a]pyrene-induced respiratory tract tumours in hamsters.
Groups of 40 Syrian golden hamsters of both sexes were fed diets containing either 5% fat (control), 20% saturated fat (beef tallow) or 20% unsaturated fat (sunflower seed oil) from weaning and during the whole experimental period (up to 656 days). Respiratory tract tumours were induced by intratracheal instillation of benzo[a]pyrene attached to ferric oxide and suspended in saline. Mortality was slightly, but not statistically significantly higher in the high fat groups than in the low fat control group. Microscopic examination of the respiratory tract revealed an increased number of tumour bearing animals, an increased multiplicity of respiratory tract tumours and an increased total number of respiratory tract tumours in animals fed high fat diets. The tumour enhancing effect of fat was most pronounced in the high unsaturated fat group. Especially epidermoid papillomas, epidermoid carcinomas and combined epidermoid and adenocarcinomas contributed to the observed differences in tumour response amongst groups. It was concluded that dietary fat enhances benzo[a]pyrene-induced respiratory tract carcinogenesis in hamsters.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000633:toxicity*; D001835:Body Weight; D002273:Carcinogens / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D006224:Cricetinae; D004041:Dietary Fats / Q000633:toxicity*; D002149:Energy Intake; D005231:Fatty Acids, Unsaturated; D005260:Female; D008297:Male; D008647:Mesocricetus; D010212:Papilloma / Q000139:chemically induced; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*; D012509:Sarcoma / Q000139:chemically induced; D012737:Sex Factors
D001580:Benzopyrenes; D002273:Carcinogens; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D001564:Benzo(a)pyrene