Interactions of ethyl-beta-carboline-3-carboxylate and Ro 15-1788 with CGS 8216 in an animal model of anxiety.
The effect of CGS 8216 (10 mg/kg) alone and in combination with the imidazodiazepine Ro 15-1788 (10 mg/kg) or ethyl-beta-carboline-3-carboxylate (beta-CCE 1 mg/kg) was tested in the social interaction test of anxiety. All 3 compounds were found to have an anxiogenic action. When Ro 15-1788 or beta-CCE was combined with CGS 8216, no mutual antagonism of the drugs' effects was observed. The failure of Ro 15-1788 to antagonize the anxiogenic action of CGS 8216 raises the possibility that CGS 8216 might be acting at a non-benzodiazepine site.
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001570:Benzodiazepinones / Q000008:administration & dosage*; D002243:Carbolines / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004347:Drug Interactions; D005442:Flumazenil; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D011720:Pyrazoles / Q000008:administration & dosage*; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects; D011963:Receptors, GABA-A; D012919:Social Behavior / Q000187:drug effects
D001570:Benzodiazepinones; D002243:Carbolines; D007211:Indoles; D011720:Pyrazoles; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005442:Flumazenil; C024915:beta-carboline-3-carboxylic acid ethyl ester; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one