Nonviral intranuclear inclusions in a nerve biopsy: an ultrastructural study.
During the ultrastructural study of a nerve biopsy from a diabetic patient suffering from chronic polyradiculoneuritis, we observed that a significant number of endoneural fibroblasts had abnormal nuclei. They contained a round, centrally located inclusion consisting of numerous irregularly arranged filaments approximately 15 nm in diameter. No such lesion in peripheral nerve has previously been reported. Interpretation of these abnormalities is difficult.
D000368:Aged; D001706:Biopsy; D002467:Cell Nucleus / Q000648:ultrastructure*; D003929:Diabetic Neuropathies / Q000473:pathology*; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D010543:Peroneal Nerve / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000473:pathology*; D012583:Schwann Cells / Q000648:ultrastructure