99mTc-diethyl-IDA: the extraction efficiency of the liver.
The extraction efficiencies of the liver were studied in rabbits by injection in the portal vein of 99mTc-IDA and 131I-Rose Bengal in two experimental conditions. In the first experiment blood samples were collected for one minute from a catheter inserted into the vena cava with the tip at the sovrahepatic veins outflow level. The vena cava was ligated upperstream. In the second experiment blood was collected from the general circulation every other minute for 20' after administration. Control experiments were performed in rabbits by administration of 99mTc-Pertechnetate and 99mTc-Albumin. The results showed that the extraction of diethyl-IDA from the blood flowing through the liver is almost total.
D000818:Animals; D006801:Humans; D007098:Imino Acids; D007457:Iodine Radioisotopes; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging*; D008102:Liver Circulation; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008954:Models, Biological; D011817:Rabbits; D011877:Radionuclide Imaging; D012395:Rose Bengal; D012709:Serum Albumin; D013670:Sodium Pertechnetate Tc 99m; D013667:Technetium; D013668:Technetium Tc 99m Aggregated Albumin; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid
D007098:Imino Acids; D007457:Iodine Radioisotopes; D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D012395:Rose Bengal; D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m; C008109:iminodiacetic acid