DNA damage induced by nitrosated ranitidine in cultured mammalian cells.
Ranitidine, a new H-2 receptor antagonist more potent than cimetidine in inhibiting gastric secretion, reacted under acid conditions with a twofold molar amount of nitrite (a nitrite/ranitidine ratio about 1000 times that likely to occur in gastric juice of treated humans) yielding a nitroso derivative capable of inducing a dose-dependent DNA fragmentation in cultured Chinese hamster ovary cells.
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D009603:Nitroso Compounds / Q000633:toxicity*; D011899:Ranitidine / Q000378:metabolism / Q000633:toxicity*
D009603:Nitroso Compounds; D011899:Ranitidine; D004247:DNA