title: Lincomycin dose response for treatment of necrotic enteritis in broilers.
abstract: A dose response study was conducted to determine the appropriate (optimal) lincomycin concentration in drinking water for the treatment of necrotic enteritis (NE) in broilers. The study was replicated twice over time using a total of 2,895 broilers. Birds were raised in a facility containing a built-up litter from a source that experienced NE. They were commingled from 1 day of age until NE was observed. Lincomycin was mixed in drinking water at a rate of 0, .528, 2.114, 8.454, or 33.818 mg/liter for a period of 7 days. The study was terminated 3 weeks after initiation of therapy. Necrotic enteritis was diagnosed by mortality and pathological findings. The data on mortality were analyzed statistically using analysis of variance procedures. The Walker-Carmer technique was applied to estimate the appropriate lincomycin concentration. Lincomycin was effective for the treatment of NE in broilers at concentrations of greater than or equal to 2.114 mg/liter of drinking water. The minimal effective dose that would achieve maximal treatment response (optimal dose) against NE in broilers was estimated to be 16.9 mg lincomycin/liter of drinking water.
mesh_terms: D000818:Animals; D002645:Chickens; D003015:Clostridium Infections / Q000188:drug therapy / Q000662:veterinary*; D003016:Clostridium perfringens; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D004751:Enteritis / Q000188:drug therapy / Q000662:veterinary*; D008034:Lincomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D009336:Necrosis; D011201:Poultry Diseases / Q000188:drug therapy*
chemical_list: D008034:Lincomycin