Stability of the radiopharmaceutical [99mTc]DMSA: study of the ligand exchange reaction with [99Tc]EDTA.
A kinetic study was made of the ligand exchange reaction between [99mTc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes--[99MTc]EDTA and [99mTc]DMSA--have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry.
D004355:Drug Stability; D004492:Edetic Acid; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D015609:Organotechnetium Compounds; D004113:Succimer; D013438:Sulfhydryl Compounds; D013667:Technetium; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013696:Temperature
D008024:Ligands; D015609:Organotechnetium Compounds; D013438:Sulfhydryl Compounds; C039918:technetium Tc 99m EDTA; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013667:Technetium; D004492:Edetic Acid; D004113:Succimer