[Nucleosome histones isolated from normal and tumor cells and the effect of bivalent metals on their conformation].
A change of the secondary structure of histones isolated from tumor cells was observed. This changed structure showed increased percentage of elongated left helix of poly-l-proline II type. It is concerned with an increased content of bivalent Ca++ and Mg++ ions.
D006528:Carcinoma, Hepatocellular; D002413:Cations, Divalent; D006657:Histones / Q000302:isolation & purification* / Q000378:metabolism; D008113:Liver Neoplasms; D009707:Nucleosomes / Q000032:analysis*; D011487:Protein Conformation
D002413:Cations, Divalent; D006657:Histones; D009707:Nucleosomes
Issledovanie nukleosomnykh gistonov, vydelennykh iz normal'nykh i opukholevykh kletok, i vliianie dvukhvalentnykh metallov na ikh konformatsiiu.