Leukocyte collagenolytic activity in normal and hydrazinophthalazine-treated rats during isoprenaline-induced cardiomyopathy.
Cardiomyopathy was produced by isoprenaline injections to healthy and hydrazinophthalazine-treated rats. The activity of leukocyte collagenase and collagenolytic cathepsin was determined on the 2nd, 7th, 19th and 21st day after the last isoprenaline injection. At the same time morphological studies of the heart muscles were carried out. It was found that alterations in enzyme activity were different in healthy and hydrazinophthalazine-treated rats. A negative synergism of isoprenaline as regards the hydrazinophthalazine action was observed in biochemical and morphological studies.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D002403:Cathepsins / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D006830:Hydralazine / Q000008:administration & dosage*; D007545:Isoproterenol / Q000008:administration & dosage; D007962:Leukocytes / Q000201:enzymology* / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D003012:Microbial Collagenase / Q000378:metabolism; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains
D006830:Hydralazine; D003094:Collagen; D002403:Cathepsins; D003012:Microbial Collagenase; D007545:Isoproterenol