Peripheral nerve damage following isolated extremity perfusion with cis-platinum.
Of 16 patients treated, all who could be examined after isolated hyperthermic lower limb perfusion with cis-platinum showed peripheral nerve damage, particularly of the lower leg and foot. We found a close correlation between the severity of neurological deficit and the perfusion temperature. The dose of cytostatic agent also plays a role in development of the nerve lesion. The major cause of the nerve damage seems to be the neurotoxicity of cis-platinum. The edematous swelling in the compartments in the lower leg have an influence. The reversibility of the pareses was generally very small.
D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005121:Extremities / Q000294:innervation*; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects; D010525:Peripheral Nerves / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D002945:Cisplatin