Human neutrophil migration is enhanced by beta-endorphin.
Using a serum-free chemotaxis-under-agarose assay, we measured the effect of beta-endorphin on directed migration of human neutrophils toward 10(-7) M N-formyl-methionyl-leucyl-phenylalanine (FMLP). Neutrophils were pre-incubated with a range of beta-endorphin concentrations. beta-endorphin enhanced migration of neutrophils toward FMLP. This effect was maximal at 10(-9) M beta-endorphin. Naloxone inhibited the beta-endorphin effect, suggesting that enhanced migration is mediated via an opiate receptor.
D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects*; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin