Possible receptor effects of chronic lithium administration.
This article will review the possible effects of chronic administration of lithium on behavioral studies and on receptor binding. Evidence suggests that lithium pretreatment might be effective in blocking the development of pharmacologically-induced behavioral dopamine supersensitivity although alterations in receptor binding may not be directly correlated to behavioral changes. Experimental results indicate that the effect of lithium may not be consistent throughout the brain, may be related to specific methods of sensitivity-induced alterations and may simultaneously alter several receptor systems.
D000818:Animals; D001519:Behavior / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008094:Lithium / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects
D011941:Receptors, Adrenergic; D011956:Receptors, Cell Surface; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; D008094:Lithium; D006220:Haloperidol; D004298:Dopamine