Hyperparathyroidism in Paget's disease of bone.
The association between Paget's disease and hyperparathyroidism was explored in 12 patients by means of a calcium loading test. Parathyroid adenomata were discovered at surgery in 2 and parathyroid hyperfunction was found in varying degrees in 4 others. Differing responses to the calcium loading test were interpreted as reflecting different stages in the bone formation-resorption disequilibrium found in Pagetic bone. A prolonged imbalance in favour of formation is suggested as constituting a stress on the homeostasis of extracellular fluid calcium levels that leads to parathyroid hyperfunction.
D000368:Aged; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D012968:Etidronic Acid / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications* / Q000378:metabolism
D000242:Cyclic AMP; D012968:Etidronic Acid; D002118:Calcium