Preservation of catecholamine uptake and release in herpes simplex virus type 1-infected PC12 cells.
The PC12 cell line, which is derived from a rat pheochromocytoma and possesses a number of 'differentiated' neuronal properties, was used to characterize the effect of herpes simplex virus type 1 (HSV-1) infection on the uptake and release of catecholamines. Both the uptake of [3H]norepinephrine and the content and K+-induced release of endogenous catecholamines were remarkably preserved during the course of productive infection. HSV-1 infection is thus selective in its effects on the host cell and certain specialized functional properties may be retained in the face of otherwise profound metabolic alterations.
D000818:Animals; D001692:Biological Transport; D002395:Catecholamines / Q000378:metabolism*; D002478:Cells, Cultured; D004298:Dopamine / Q000378:metabolism; D006561:Herpes Simplex / Q000378:metabolism*; D009474:Neurons / Q000382:microbiology; D010673:Pheochromocytoma; D011188:Potassium / Q000502:physiology; D051381:Rats; D018139:Simplexvirus / Q000502:physiology
D002395:Catecholamines; D011188:Potassium; D004298:Dopamine