Lithium at therapeutic concentrations inhibits human brain noradrenaline-sensitive cyclic AMP accumulation.
Lithium at a therapeutically effective concentration of 1 mM caused significant inhibition of the rise in cyclic AMP induced by noradrenaline in fresh surgically-obtained slices of human brain.
D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D000242:Cyclic AMP / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000494:pharmacology; D009638:Norepinephrine / Q000502:physiology*
D008094:Lithium; D000242:Cyclic AMP; D009638:Norepinephrine