Long-term potentiation of hippocampal synaptic transmission affects rate of behavioral learning.
Electrical stimulation techniques were used to produce a long-lasting potentiation of synaptic transmission in the hippocampus of naïve rabbits. Animals were then classically conditioned. Long-term potentiation of the hippocampus before training increased the rate at which animals subsequently learned the conditioning task. This result has significance for potential cellular mechanisms of associative learning.
D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D008297:Male; D009541:Nictitating Membrane / Q000502:physiology; D011817:Rabbits; D017981:Receptors, Neurotransmitter / Q000502:physiology; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
D017981:Receptors, Neurotransmitter