title: Adrenergic control of the anuran cutaneous hydroosmotic response.
abstract: Adrenergic effectors were shown to play a major role in increasing cutaneous water uptake (the hydroosmotic response) in dehydrated anurans. A beta-adrenergic antagonist, propranolol, blocked 61% of the cutaneous response to dehydration and 67% of the response elicited by salt loading in the toad Bufo cognatus. A beta-adrenergic agonist, isoproterenol, elicited a response in normally hydrated animals equal to the propranolol-sensitive portion of the cutaneous hydroosmotic response of dehydrated animals. The isoproterenol-induced cutaneous water balance response in hydrated animals greatly exceeded the response induced by arginine vasotocin, the endogenous antidiuretic hormone.
mesh_terms: D000818:Animals; D002025:Bufonidae / Q000378:metabolism*; D003681:Dehydration / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D014668:Vasotocin / Q000494:pharmacology; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D011943:Receptors, Adrenergic, beta; D014867:Water; D011433:Propranolol; D007545:Isoproterenol; D014668:Vasotocin