The response to potassium of the Na-K pump ATPase in low-K red blood cells from cattle at birth and in later life.
It is shown that in low-K red blood cells of cattle the apparent affinity for K(1/Kapp K) at an inhibitory site of the Na-K ATPase increases markedly during the first 3 months of life. This site probably is the Na accepting site at the internal membrane surface and the change in Kapp K reflects an increase in KNa/KK, the ratio of the true dissociation constants. This effect may explain the concomitant fall in cellular K concentration.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000097:blood; D002417:Cattle; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D011188:Potassium / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium