[Effect of chronic use of antidepressants on the state of benzodiazepine receptors in the mouse brain].
A study was made of the effect of a two-week administration of chlorimipramine, zimelidine and a morpholine derivative on benzodiazepine receptors of the mouse brain. The animals which received antidepressants demonstrated a significant increase in the binding sites of 3H-flunitrazepam without any changes in the dissociation constant as compared to control. The data on the evoked aggressiveness and latency of tonic corasole convulsions in the antidepressant-treated animals support the functional importance of the discovered changes in benzodiazepine receptors.
D000284:Administration, Oral; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D001665:Binding Sites / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001977:Brompheniramine / Q000008:administration & dosage / Q000031:analogs & derivatives; D002997:Clomipramine / Q000008:administration & dosage; D005445:Flunitrazepam / Q000378:metabolism; D008297:Male; D051379:Mice; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D011963:Receptors, GABA-A; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D015031:Zimeldine
D000928:Antidepressive Agents; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D015031:Zimeldine; D005445:Flunitrazepam; D001977:Brompheniramine; D002997:Clomipramine
Vliianie khronicheskogo primeneniia antidepressantov na sostoianie benzodiazepinovykh retseptorov golovnogo mozga myshi.