title: Biodegradation behavior of various calcium phosphate materials in bone tissue.
abstract: In order to study the biodegradation behavior of calcium phosphate materials, cylinders of standard size were implanted in the tibiae of rabbits. Material parameters were stoichiometry (hydroxyapatite with a Ca/P ratio of 1.67 versus tricalcium phosphate with a Ca/P ratio of 1.50), crystallographic structure (apatite versus beta-whitlockite), microporosity, and macroporosity. The extent of biodegradation was evaluated by radiography, light and fluorescence microscopy, microradiography, and porosity measurements. All calcium phosphate materials were biocompatible in bone tissue. Hydroxyapatite ceramics had a higher osteogenic potential than beta-whitlockite materials. Depending on their porosities, sintered tricalciumphosphate (beta-whitlockite) materials were more or less biodegradable, in contrast to sintered hydroxyapatite materials, which showed no detectable resorption over a period of 9 months of implantation.
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D001673:Biodegradation, Environmental; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002130:Calcium Phosphates / Q000378:metabolism*; D002516:Ceramics; D017886:Durapatite; D006882:Hydroxyapatites / Q000378:metabolism; D008297:Male; D019736:Prostheses and Implants; D011817:Rabbits; D011859:Radiography; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C021767:whitlockite; D017886:Durapatite