title: Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues.
abstract: Tizanidine behaved as the partial agonist on the alpha 1-adrenoceptor in high doses (10(-6) -10(-4)M) and as the alpha 2-adrenoceptor agonist in low doses (3 X 10(-9) - 10(-6)M). Tizanidine is about one-third as potent as clonidine in alpha 2-agonistic effect
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D009125:Muscle Relaxants, Central; D011942:Receptors, Adrenergic, alpha; C023754:tizanidine; D003000:Clonidine