Virus-associated hemophagocytic syndrome due to Epstein-Barr virus.
The clinical and autopsy findings in a case of virus-associated hemophagocytic syndrome in a previously healthy 17-year-old girl are presented. Serum titers to Epstein-Barr viral antigens were unusually elevated. In addition to widespread proliferation of hemophagocytic histiocytes and lymphoid depletion, there were areas of non-suppurative necrosis in lymph nodes and spleen, which have not been previously reported.
D000293:Adolescent; D005260:Female; D006566:Herpesviridae Infections; D004854:Herpesvirus 4, Human; D006801:Humans; D008206:Lymphatic Diseases / Q000209:etiology* / Q000473:pathology; D010587:Phagocytosis