Methylprednisolone preservation of motor nerve function during early degeneration.
Intensive pretreatment of cats with methylprednisolone acetate (8 mg/kg, i.m. once daily for 7 days) was found to significantly preserve the functional capabilities of degenerating soleus motor nerve terminals, as measured at 48 h after motor axon section in the in vivo soleus nerve-muscle preparation. This effect is similar to that reported previously for triamcinolone, another glucocorticoid.
D000818:Animals; D000842:Ankle; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D009046:Motor Neurons / Q000187:drug effects; D009132:Muscles / Q000294:innervation*; D009410:Nerve Degeneration / Q000187:drug effects*; D009411:Nerve Endings / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D008775:Methylprednisolone