Ependymoma, glioblastoma, and acute leukemia in a child.
A 5-year-old boy developed an ependymoma; 3 years later, after chemotherapy and radiotherapy, he developed glioblastoma multiforme and acute myeloblastic leukemia. His maternal grandmother had died at a young age of colon cancer. Since ependymoma is not known to predispose to other cancers, the unusual sequence of malignant disease may have been due to combined therapy in a susceptible host.
D001932:Brain Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D002675:Child, Preschool; D004806:Ependymoma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D005909:Glioblastoma / Q000150:complications*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology