The effect of binding divalent metal ions on the conformation of human angiotensin-II in solution as probed by nuclear and electron paramagnetic resonance investigations.
The interaction between human angiotensin-II and Mn(II) ions in water solution has been delineated by nmr and esr experiments. A pH-dependent binding interaction with the imidazole moiety of His 6 has been shown, ratifying the suggestion that His 6 is involved in intramolecular structuring within the peptide molecule.
D000804:Angiotensin II; D002413:Cations, Divalent / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese / Q000494:pharmacology; D011485:Protein Binding; D011487:Protein Conformation / Q000187:drug effects
D002413:Cations, Divalent; D000804:Angiotensin II; D008345:Manganese