Immunocytochemical demonstration of insulin in spontaneous pancreatic islet cell tumors of Fischer rats.
Nineteen spontaneous pancreatic islet cell tumors were studied in 26-month-old control Fischer 344 rats. Seventeen of 19 (89%) tumors demonstrated insulin reactivity using peroxidase-antiperoxidase immunocytochemistry. None of ten tumors had positive glucagon immunoreactivity. Immunocytochemical and ultrastructural observations suggested that spontaneous occurring islet cell tumors of F344 rats were composed exclusively of beta cells.
D007516:Adenoma, Islet Cell / Q000378:metabolism / Q000648:ultrastructure / Q000662:veterinary*; D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D007328:Insulin / Q000378:metabolism*; D007340:Insulinoma / Q000378:metabolism / Q000648:ultrastructure / Q000662:veterinary*; D007515:Islets of Langerhans / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000648:ultrastructure / Q000662:veterinary*; D051381:Rats; D011916:Rats, Inbred F344 / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012189:Retrospective Studies; D012376:Rodent Diseases / Q000378:metabolism* / Q000473:pathology
D007328:Insulin