Herpes simplex virus-induced amplification of SV40 sequences in transformed Chinese hamster embryo cells.
Infection with Herpes simplex viruses (HSV) induces amplification of SV40 sequences in SV40-transformed Chinese hamster embryo cells (CO631). This is shown by in situ hybridization of the infected cells with cloned 32P-labelled SV40 DNA. The HSV-mediated synthesis of SV40 DNA is more pronounced than after treatment with chemical carcinogens. This initiator-like effect of HSV may, in concert with the previously reported mutagenic activity of this virus (Schlehofer and zur Hausen, 1982), point to a possible mechanism of HSV infection in human genital cancer.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D002460:Cell Line; D002472:Cell Transformation, Viral; D003043:Cocarcinogenesis; D006224:Cricetinae; D003412:Cricetulus; D004279:DNA, Viral / Q000096:biosynthesis*; D005784:Gene Amplification; D006561:Herpes Simplex / Q000378:metabolism*; D013539:Simian virus 40 / Q000235:genetics*
D002273:Carcinogens; D004279:DNA, Viral