[The role of lipids in the changes in the properties of the brain beta-adrenoreceptors during emotional stress].
The role of phospholipid hydrolysis by phospholipase A2 and lipid peroxidation in changes of the properties of beta-adrenoreceptors in rat brain synaptosomes in severe emotional painful stress (EPS) has been evaluated. It has been shown that EPS does not influence lipid and fatty acid content of synaptosomal membranes but significantly increases the amount of lipid peroxidation products. Activation of lipid peroxidation in EPS causes a decrease in specific binding of 3H-dihydroalprenolol. The free radical scavenger, 4-methyl-2,6-di(tret-butyl)phenol completely prevents activation of lipid peroxidation and eliminates the disturbances in ligand-receptor interactions in EPS.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004082:Dihydroalprenolol / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D008051:Lipid Bilayers / Q000378:metabolism; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D008051:Lipid Bilayers; D008054:Lipid Peroxides; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol; D010741:Phospholipases A; D054467:Phospholipases A2
Rol' lipidov v izmenenii svoĭstv beta-adrenoretseptorov mozga pri émotsional'no-bolevom stresse.