Noradrenaline controls the concentration of the uncoupling protein in brown adipose tissue.
The importance of noradrenaline in the control of the level of the uncoupling protein responsible for the high thermogenic capacity of brown adipose tissue mitochondria was examined. It was observed that chronic infusion of noradrenaline through mini-osmotic pumps increased the mitochondrial concentration of this uncoupling protein to the same extent as chronic exposure to cold.
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins; D004247:DNA / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D007473:Ion Channels; D007700:Kinetics; D050356:Lipid Metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D024101:Mitochondrial Proteins; D009638:Norepinephrine / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; D000071256:Uncoupling Protein 1; D004247:DNA; D003576:Electron Transport Complex IV; D009638:Norepinephrine