title: New surgical procedure for management of Peyronie disease.
abstract: Surgical excision of fibrotic plaques and replacement of the defect by grafts may be necessary in advanced Peyronie disease. Synthetic, absorbable mesh for grafting the defect was used in 6 mongrel dogs. An area of tunica albuginea 1.5 by 2.5 cm was removed from the corpus cavernosum, thus exposing the spongy cavernous tissue. A Dexon mesh of the same dimensions, woven in our laboratory from polyglycolic acid fibers of 308 denier thickness, was sutured to the defect by 3-0 Dexon sutures. The mesh caused hemostasis and the animals' postoperative course was uneventful. Posterection cavernosograms showed no curvature of the penis, bulging of the operative area, or obstruction of the corpora cavernosa. Histologic studies at three weeks, and two, four, and six months after surgery showed complete healing and gradual replacement of the Dexon mesh by fibrous connective tissue.
mesh_terms: D000818:Animals; D003238:Connective Tissue / Q000502:physiology; D004285:Dogs; D008297:Male; D010411:Penile Induration / Q000601:surgery*; D011100:Polyglycolic Acid; D013526:Surgical Mesh; D013537:Sutures; D014945:Wound Healing
chemical_list: D011100:Polyglycolic Acid