Diethyldithiocarbamate depresses the acoustic startle response in rats.
The relationship between norepinephrine (NE) content in cortex and spinal cord and acoustic startle amplitude was investigated in two experiments. Administration of diethyldithiocarbamate (DDC) depressed startle amplitude at the same time and dose that it most severely depleted NE content. These results support the conclusion that NE facilitates the normal elaboration of the acoustic startle reflex and also support evidence that NE activity in the spinal cord may be of particular importance in the maintenance of normal startle amplitude.
D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D002246:Carbon Disulfide / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D004221:Disulfiram / Q000378:metabolism; D004050:Ditiocarb / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects*; D013859:Thiocarbamates / Q000494:pharmacology*
D013859:Thiocarbamates; D004050:Ditiocarb; D002246:Carbon Disulfide; D004221:Disulfiram; D004298:Dopamine; D009638:Norepinephrine