title: Biotransformation of organophosphorus compounds relative to delayed neurotoxicity.
abstract: In summary, although there is considerable information on he biotransformation of OP compounds, there are some deficiencies in our knowledge of the biotransformation of phosphonothionate delayed neurotoxicants. Various anomalies, such as the species variations, limited absorption and unique disposition, phenyl phosphonothionate vs. alkyl phosphonothionate potency, O-methyl phenylphosphonothionate vs. O-ethyl phenylphosphonothionate potency, and the relative contributions of various activation and detoxication pathways still exist. The understanding of the syndrome of delayed neurotoxicity will come from receptor/mechanism studies, but by increasing our knowledge of comparative biotransformation, we can insure that our concepts are less distorted by "extraneous" influences. Moreover, since the ultimate goal is to define the syndrome as it relates to the whole organism for predictive and safety considerations, influences such as biotransformation and disposition are no longer extraneous but critical.
mesh_terms: D000818:Animals; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003640:Dealkylation; D003576:Electron Transport Complex IV / Q000378:metabolism*; D004950:Esterases / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008658:Inactivation, Metabolic; D007306:Insecticides / Q000378:metabolism* / Q000633:toxicity; D008862:Microsomes, Liver / Q000201:enzymology*; D009249:NADP; D009420:Nervous System / Q000187:drug effects; D009943:Organophosphorus Compounds; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
chemical_list: D007306:Insecticides; D009943:Organophosphorus Compounds; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D003576:Electron Transport Complex IV; D005982:Glutathione Transferase; D004950:Esterases