title: Reduction in cortical beta adrenergic receptor density after chronic intermittent food deprivation.
abstract: The effect of chronic intermittent food deprivation on beta adrenergic receptor binding in the rat brain was studied. Rats subjected to six 48 h fasts given over a period of 3 weeks demonstrated a reduction in the density of beta adrenergic receptors in the cerebral cortex but not in the hypothalamus or lower brainstem. This receptor alteration did not occur after one 48 h fast. This effect of chronic food deprivation is shared by several other forms of repeated stress, suggesting that it is a general mechanism of adaptation.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D001933:Brain Stem / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005508:Food Deprivation; D007031:Hypothalamus / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000032:analysis; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D011943:Receptors, Adrenergic, beta