Effect of purinergic substances on rectal temperature in mice: involvement of P1-purinoceptors.
Effect of adenosine, 2-chloroadenosine (P1-purinoceptor agonists) and adenosine triphosphate (ATP), adenosine-5'-tetraphosphate (P2-purinoceptor agonists) on body temperature was studied in mice. Adenosine (7.5-200 mg/kg) as well as 2-chloroadenosine (0.25-7.5 mg/kg) induced hypothermia in a dose-dependent manner. However, ATP or adenosine-5'-tetraphosphate did not show any effect on body temperature. Caffeine and theophylline, P1-purinoceptor antagonists, blocked the hypothermic response of adenosine and 2-chloroadenosine. Treatment with quinidine or phenoxybenzamine (non-specific P2-purinoceptor antagonists) did not modify the hypothermic response. Similarly, treatment with drugs which modify adrenergic (reserpine, propranolol, labetalol or haloperidol), serotonergic (cyproheptadine) or histaminergic functions failed to block adenosine or 2-chloroadenosine-induced hypothermia. These results demonstrated that P1-purinoceptors mediated the hypothermic response of these purines.
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006633:Histamine Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D011687:Purines / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D011983:Receptors, Purinergic; D012702:Serotonin Antagonists / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology
D006633:Histamine Antagonists; D011687:Purines; D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D012702:Serotonin Antagonists; D013565:Sympatholytics; D015762:2-Chloroadenosine; D000241:Adenosine