[Etiological aspects of leukemias in primates including man].
Attempts have been made to induce viral leukemia in monkeys (Papio hamadryas and Macaca arctoides) by inoculating them with blood from humans with different types of leukemias. In hamadryas baboons, the disease spread horizontally. By today 218 P. hamadryas and 5 M. arctoides monkeys had died of malignant lymphoma. The following viruses have been isolated from sick monkeys: lymphotropic baboon herpes virus (HVP), endogenous baboon C type viruses--xenotropic (BILN), and ecotropic (EVPG). C type oncovirus called "plasmic", which differs immunologically from the endogenous one, was also detected in the blood of sick animals. Altogether 165 sera from baboons, different species of macacas and chimpanzee were examined by the immunofluorescent technique for antibodies to HTLV virus isolated recently from sick humans with T cell leukemia/lymphoma. Antibodies to HTLV virus were detected only in monkeys (P. hamadryas and M. arctoides) with malignant lymphomas or in those which had been in close contact with them. Possible origin of simian HTLV-like virus is discussed. It originates either from leukemic patients or there is a family of primate HTLV like viruses related to the occurrence of leukemia.
D000818:Animals; D017977:Deltaretrovirus / Q000302:isolation & purification; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000662:veterinary; D007942:Leukemia, Experimental / Q000209:etiology*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008255:Macaca radiata; D008992:Monkey Diseases / Q000209:etiology*; D010215:Papio; D012190:Retroviridae / Q000302:isolation & purification; D014412:Tumor Virus Infections / Q000635:transmission*
Nekotorye aspekty étiologii leĭkozov primatov, vkliuchaia cheloveka.