[Bourneville's tuberous sclerosis in twin sisters].
A pair of female homozygous twins with tuberous sclerosis are presented. Both girls showed focal and generalized seizures from the first month of life and also infantile spasms at eight months. Control of seizures was only obtained on the girl who shows now an intelligence a little lower than her sister continuing with focal and/or generalized crisis at least every month. However, mental retardation is important in both sisters. Hypomelanotic spots on the skin were few and very small in both girls. Computed tomography scan of the head showed wide zones of calcification on cerebral hemispheres in both patients from the first months of life. Density of these calcifications experimented great increase with age.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007223:Infant; D011247:Pregnancy; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000188:drug therapy / Q000235:genetics*; D014430:Twins, Monozygotic
D000324:Adrenocorticotropic Hormone
Esclerosis tuberosa de Bourneville en dos hermanas gemelas.