Effect of gold compounds on phorbol myristic acetate (PMA) activated superoxide (O2-) production by mouse peritoneal macrophages.
A number of gold compounds, nonsteroidal antiinflammatory drugs (NSAID) and protease inhibitors have been examined for their ability to inhibit the respiratory burst of peritoneal macrophages. A potent (IC50 = 5 microM or less) dose dependent inhibitory activity was seen with a number of triethylphosphine gold I ( TEPG ) compounds. Nonphosphine gold compounds were less active. The ligands of TEPG were inactive. Several NSAID stimulated the respiratory burst, whereas 2 protease inhibitors tested were inhibitory. The structure activity relationship of TEPG is also presented.
D000818:Animals; D006046:Gold / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009821:Oils / Q000494:pharmacology; D050607:Organogold Compounds; D009942:Organometallic Compounds; D010537:Peritoneum / Q000166:cytology; D010704:Phorbols / Q000494:pharmacology*; D010720:Phosphines; D012119:Respiration / Q000187:drug effects; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D009821:Oils; D050607:Organogold Compounds; D009942:Organometallic Compounds; D010704:Phorbols; D010720:Phosphines; D013481:Superoxides; C016797:triethyl phosphine gold; D006046:Gold; D013755:Tetradecanoylphorbol Acetate