Comparative study of stress reactions during oral surgery after pindolol and metoprolol.
The prophylactic effect of a single oral dose of 5 mg pindolol (P) or 100 mg metoprolol (M) on sympathetic and adrenergic stress reactions was investigated by a double blind study in 40 patients undergoing oral surgery. A reduction of systolic and diastolic blood pressure as well as heart rate was noted after both, P and M, as was the increase of these parameters during surgery. Adrenaline-, noradrenaline- and c-AMP-level were reduced after systematic beta-blockade by P only, not after M. The increased lipolysis and glycolysis during surgery were prevented by P only. The stimulation of the hypothalamic and adrenal stress reactions were not influenced by either P or M. The application of the systematic beta-blocker with ISA (P) only was suited to prevent the increase of catecholamine levels in plasma and peripheral receptor stimulation.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D000242:Cyclic AMP / Q000097:blood; D004311:Double-Blind Method; D004562:Electrocardiography; D004837:Epinephrine / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D009055:Mouth / Q000601:surgery; D009638:Norepinephrine / Q000097:blood; D010869:Pindolol / Q000494:pharmacology*; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D000324:Adrenocorticotropic Hormone; D010869:Pindolol; D000242:Cyclic AMP; D008790:Metoprolol; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine