title: Functional and morphologic changes associated with insulinoma transplantation into diabetic rats.
abstract: Because of the technical difficulties encountered with human islet cell transplantation, alternatives toward supplying the juvenile diabetic with an endogenous insulin source are sought. With the use of a streptozotocin-induced diabetic rat model, it was found that by transplantation of a benign insulinoma, the glomerular deposition of material stained by the periodic acid-Schiff method, IgG, IgM, and C3 may be prevented. This effect was found only when transplantation of the insulin-producing tumor occurred within 2-4 weeks of the induction of diabetes. The data suggest that successful insulinoma engraftment can prevent the glomerular mesangial lesions from developing.
mesh_terms: D007516:Adenoma, Islet Cell / Q000473:pathology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D005455:Fluorescent Antibody Technique; D007340:Insulinoma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D010179:Pancreas / Q000473:pathology / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains