Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes.
Two regions of mouse DNA which constitute common provirus integration sites in tumors induced by mouse mammary tumor virus have been identified and designated int-1 and int-2. By examining a series of hamster-mouse somatic cell hybrids, we mapped the int-2 locus to mouse chromosome 7 and confirmed the previous assignment of int-1 to chromosome 15. This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease.
D000818:Animals; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis*; D006822:Hybrid Cells; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D009857:Oncogenes
D004247:DNA