title: [Viruses and juvenile diabetes mellitus].
abstract: Much clinical and experimental data is in support of a significant role played by viruses in the etiology of diabetes mellitus. This hypothesis is borne out by the association of diabetes mellitus with Coxsackie B, mumps, rubella and herpes simplex virus infections, the presence of high persistent titers of neutralizing antibodies in diabetic patients, the in vitro permissiveness of human beta cells to viruses, and the recovery of viruses from the pancreas of diabetic patients. Viral multiplication is facilitated in HLA B8, B15, B18, Dw3 and Dw4 carriers. Experimental inoculation of EMC and Coxsackie B viruses to mice shows that beta cell involvement is dependent upon viral strains, viral membrane receptors, interferon production, immunological response and less essential factors such as age and sex. The virus is responsible for a specific immunological response and produces autoimmunological phenomena. These result in a decrease in the number and activity of insulin-producing cells through cytotoxic mechanisms. Pathological findings corroborate these physiopathological hypotheses.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001327:Autoimmune Diseases; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis; D006566:Herpesviridae Infections / Q000150:complications; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D010179:Pancreas / Q000382:microbiology; D010850:Picornaviridae Infections / Q000150:complications; D010253:Respirovirus Infections / Q000150:complications; D012409:Rubella / Q000150:complications; D014777:Virus Diseases / Q000150:complications* / Q000276:immunology; D014780:Viruses / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D006680:HLA Antigens
vernacular_title: Virus et diabète juvénile.