title: Inhibition of adenosine 3',5'-monophosphate accumulation and lipolysis by adenosine analogs in human subcutaneous adipocytes.
abstract: Lipolysis and cAMP accumulation were inhibited by low concentrations of adenosine and its analogs in human sc adipocytes stimulated by 2 microM DL-isoproterenol. The order of potency of the adenosine analogs tested was N6-(phenylisopropyl)adenosine greater than 2-chloroadenosine greater than 5'-N-ethylcarboxamidoadenosine greater than adenosine greater than 2',5'-dideoxyadenosine greater than 2'-deoxyadenosine. Inosine was without effect. No stimulation of cAMP accumulation by 5'-N-ethylcarboxamidoadenosine was observed. These results strongly suggest the presence of inhibitory adenosine Ri- and P-sites and the absence of stimulatory Ra-sites in human sc adipocytes.
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000242:Cyclic AMP; D000241:Adenosine; D007545:Isoproterenol