Beta-lactamase stability of cefoxitin in comparison with other beta-lactam compounds.
The beta-lactamase stability of cefoxitin, the second-generation cephamycin compound, was compared with that of cefamandole, cefoperazone, cefotaxime, moxalactam, carbenicillin, and piperacillin. Unlike cefamandole, cefoperazone, carbenicillin, and piperacillin, cefoxitin was not hydrolyzed by the common plasmid beta-lactamases, TEM-1, TEM-2, OXA-2, and SHV-1. Cefoxitin and moxalactam were the only agents stable to all chromosomal beta-lactamases, whereas cefamandole, cefoperazone, cefotaxime, carbenicillin, and piperacillin were destroyed by cephalosporinases of Proteus vulgaris and Bacteroides fragilis.
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002228:Carbenicillin / Q000378:metabolism; D002435:Cefamandole / Q000378:metabolism; D002438:Cefoperazone / Q000378:metabolism; D002439:Cefotaxime / Q000378:metabolism; D002440:Cefoxitin / Q000378:metabolism*; D002510:Cephalosporinase / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000201:enzymology; D009070:Moxalactam / Q000378:metabolism; D010405:Penicillinase / Q000378:metabolism; D010878:Piperacillin / Q000378:metabolism; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002435:Cefamandole; D002440:Cefoxitin; D002438:Cefoperazone; D002510:Cephalosporinase; D010405:Penicillinase; D001618:beta-Lactamases; D002228:Carbenicillin; D002439:Cefotaxime; D009070:Moxalactam; D010878:Piperacillin