Effect of dietary antioxidants on benzo[a]pyrene metabolism in rat liver microsomes.
Feeding of rats with 1% ethoxyquin (EQ) and butylated hydroxytoluene (BHT) but not butylated hydroxyanisole (BHA) increases the formation rate of benzo[a]pyrene (BP)-4,5-dihydrodiol from BP in hepatic microsomes. The production of other BP-dihydrodiols and of BP phenols is decreased after treatment with EQ, BHT and BHA. EQ and BHT are more effective than BHA in inducing epoxide hydrolase (EH) activity towards styrene oxide as the substrate.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002273:Carcinogens / Q000378:metabolism*; D005015:Ethoxyquin / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D001580:Benzopyrenes; D002273:Carcinogens; D002084:Butylated Hydroxytoluene; D001564:Benzo(a)pyrene; D005015:Ethoxyquin