The efficacy of agonists at the frog neuromuscular junction studied with single channel recording.
The efficacy of acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction was estimated by single channel recording. The probability of channel opening at high concentration was found to be greater than 0.9 for each, thus showing (a) that their efficacy is high and (b) that the opening rate for the fully-liganded channel is higher than previously thought.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D004594:Electrophysiology; D007473:Ion Channels / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D011896:Rana temporaria
D007473:Ion Channels; C009335:subecholine; D002217:Carbachol; D002794:Choline; D000109:Acetylcholine