[Selection of cultures of microscopic fungi synthesizing phosphomonoesterase inhibitors].
The work was aimed at studying the ability of Aspergillus and Penicillium species to isolate phosphomonoesterases (PMEases) in the cultural broth in the course of submerged cultivation in a complex nutrient medium. The cultures produced both acid and alkaline PMEases, but acid PMEase was produced at a much greater rate than alkaline PMEase. The activity of acid and alkaline PMEases decreased in most cases when the cultural broth and cell-free extracts were incubated with urea. The activity of exocellular acid PMEases was inhibited by the cell-free extracts of most cultures. The inhibition of PMEases from different sources is manifested in the studied cultures of Aspergillus and Penicillium in a different manner.
D001230:Aspergillus / Q000201:enzymology*; D003470:Culture Media / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D010407:Penicillium / Q000201:enzymology*; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D012641:Selection, Genetic; D013045:Species Specificity; D014508:Urea / Q000378:metabolism
D003470:Culture Media; D014508:Urea; D010744:Phosphoric Monoester Hydrolases
Otbor kul'tur mikroskopicheskikh gribov, sinteziruiushchikh ingibitory fosfomonoésteraz.