[Burkitt's acute lymphoblastic leukemia. Incidence and cytogenetic aspects].
We report 4 cases of patients, 5, 16, 31 and 55 years old respectively, with Burkitt type ALL. Three of them presented with a hypoaesthesia of the chin tip. The cytological features of abnormal cells were those of L3 subgroup in the FAB classification; they expressed surface immunoglobulin markers. EBV serology was positive in two cases but the titres did not indicate a recent infection. The translocation t(8;14) (q24;q32) was found in all 4 patients. In one case, it was possible to characterize a clone with a 7 neochromosome (7p+) and a clone with a supernumerary 7 isochromosome i(7q)+; in other respects these two clones showed the translocation t(8;14) and only the latter remained in the terminal phase. In these 4 patients the disease progressed dramatically even when haematological remission was obtained (two cases), predominantly due to early neuro-meningeal involvement.
D000293:Adolescent; D000328:Adult; D002051:Burkitt Lymphoma / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000473:pathology; D002675:Child, Preschool; D002999:Clone Cells / Q000473:pathology; D005260:Female; D005602:France; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
Leucémie aiguë lymphoblastique de type Burkitt. Fréquence et aspects cytogénétiques.