title: Preliminary report on progesterone effect on peripheral estrone sulfate metabolism.
abstract: The effect of progesterone (P) on peripheral estrone sulfate (E1S) was investigated in postmenopausal women using E1S constant infusions. The metabolic clearance rate of E1S (MCRE1S) was significantly lowered by P administration (p less than 0.01), while no significant changes were observed for E1S----E1 conversion ratio. The present findings suggest that P can affect the E1S peripheral fate inducing deep changes in estrogen equilibrium.
mesh_terms: D004958:Estradiol / Q000097:blood; D004966:Estrogens, Conjugated (USP) / Q000097:blood*; D004970:Estrone / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D011374:Progesterone / Q000494:pharmacology*
chemical_list: D004966:Estrogens, Conjugated (USP); D004970:Estrone; D011374:Progesterone; D004958:Estradiol; C017296:estrone sulfate