Elevated serum angiotensin-converting enzyme in hyperthyroidism.
Serum angiotensin-converting enzyme was elevated in patients with hyperthyroidism (72 +/- 31 nmol/minute/ml, n = 12, p less than 0.001) but not in patients with hypothyroidism (38 +/- 3, n = 3) or thyroiditis (26, n = 1), and was positively correlated in 23 patients with serum thyroxine concentration (r = 0.60, p less than 0.01) and triiodothyronine resin uptake (r = 0.56, p less than 0.01). Triiodothyronine failed to enhance the synthesis of angiotensin-converting enzyme in rabbit alveolar macrophages or in human monocytes in culture, suggesting that the increased serum enzyme is a consequence of an effect other than increased angiotensin-converting enzyme synthesis. Hyperthyroidism should be considered in the evaluation of serum angiotensin-converting enzyme for the diagnosis and management of sarcoidosis.
D003907:Dexamethasone / Q000494:pharmacology; D006801:Humans; D006980:Hyperthyroidism / Q000201:enzymology*; D007037:Hypothyroidism / Q000201:enzymology; D008264:Macrophages / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis / Q000097:blood*; D013966:Thyroiditis / Q000201:enzymology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D003907:Dexamethasone; D007703:Peptidyl-Dipeptidase A; D013974:Thyroxine