Tissue distribution of angiotensin converting enzyme in the rat: effect of captopril treatment.
Effect on different tissues with regard to angiotensin converting enzyme during captopril treatment in the rat was studied. Male Wistar-Kyoto rats (n = 9) were treated during four weeks with captopril dissolved into the drinking water at the dose 30 mg/kg/day. Control rats (n = 9) had water only. Serum angiotensin converting enzyme (ACE) activity increased three-fold during captopril treatment, and ACE of purified pulmonary plasma membranes increased about 64% (P less than 0.001) compared to untreated rats. ACE activity of membrane fractions of other tissues studied i.e. testicles, epididymes, kidneys, and small intestine brush border did not increase similarly during captopril treatment. The highest amounts of ACE was demonstrated in epididymes, but captopril did not produce increased amounts of ACE in the epididymes. The main source of increased serum ACE activity during captopril treatment appeared to be in the pulmonary tissue.
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology; D004656:Enalapril; D004822:Epididymis / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008297:Male; D008871:Microvilli / Q000201:enzymology; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011392:Proline / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000201:enzymology
D004151:Dipeptides; D004656:Enalapril; D011392:Proline; D002216:Captopril; D007703:Peptidyl-Dipeptidase A