Regional localization of alpha-galactosidase (GLA) to Xpter----q22, hexosaminidase B (HEXB) to 5q13----qter, and arylsulfatase B (ARSB) to 5pter----q13.
Two series of somatic cell hybrids were made by fusion of human cells with karyotypes 46,X,t(X;2;15)(q22;p12;p12) and 46,XX,t(5;7)(q13;p15) and rodent cells. Chromosome and isozyme analysis of human chromosomes and gene products in the hybrids localized GLA to Xpter----q22, HEXB to 5q13----qter, in both cases narrowing the regional assignments, and ARSB to 5pter----q13.
D000818:Animals; D002460:Cell Line; D002871:Chromosome Banding; D002999:Clone Cells; D005260:Female; D005696:Galactosidases / Q000235:genetics*; D005796:Genes; D054819:Hexosaminidase B; D006596:Hexosaminidases / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology*; D007527:Isoenzymes / Q000235:genetics; D007621:Karyotyping; D051379:Mice; D014178:Translocation, Genetic; D014960:X Chromosome; D000519:alpha-Galactosidase / Q000235:genetics*; D001619:beta-N-Acetylhexosaminidases
D007527:Isoenzymes; D005696:Galactosidases; D006596:Hexosaminidases; D000519:alpha-Galactosidase; D054819:Hexosaminidase B; D001619:beta-N-Acetylhexosaminidases