title: Evaluation of lithium as an inhibitory agent of herpes simplex virus in cell cultures and during reactivation of latent infection in rabbits.
abstract: Lithium carbonate inhibited plaque formation of herpes simplex virus types 1 and 2 in rabbit kidney and Vero cells (50% effective dose, 435.5 to 490 micrograms/ml). Plasma lithium levels of 67 to 134 micrograms/ml were achieved by oral therapy in rabbits. However, neither ocular virus shedding nor virus-positive trigeminal ganglia were reduced after intentional reactivation of latent herpes simplex virus infection.
mesh_terms: D000818:Animals; D006561:Herpes Simplex / Q000188:drug therapy*; D007668:Kidney; D008094:Lithium / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D011817:Rabbits; D012008:Recurrence; D018139:Simplexvirus / Q000187:drug effects*; D010948:Viral Plaque Assay; D014776:Virus Cultivation
chemical_list: D008094:Lithium