Blood monocyte aryl hydrocarbon hydroxylase activity in psoriasis.
The activity of aryl hydrocarbon hydroxylase (AHH) in monocytes from 13 healthy control subjects and in 16 patients with discoid psoriasis was measured. The mean basal monocyte AHH activities of the control and psoriatic groups were 3.4 +/- 0.47 and 4.46 +/- 0.55 respectively (pmol 3-OHBP h-1 10(-6) cells). This difference was not significant. The mean induced monocyte AHH activities in the control and psoriatic groups were 56.4 +/- 10.8 and 77.8 +/- 16.0 pmol 3-OHBP h-1 10(-6) cells respectively but this difference was not significant. The mean induction ratios in the control and psoriatic groups were 16.5 +/- 1.8 and 20.4 +/- 3.6 respectively. Again, this difference was not significant. We conclude therefore, that monocyte aryl hydrocarbon hydroxylase activity is not reduced in psoriasis.
D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000097:blood*; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism; D001711:Biotransformation; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009000:Monocytes / Q000201:enzymology*; D011565:Psoriasis / Q000201:enzymology*
D001580:Benzopyrenes; D001564:Benzo(a)pyrene; D001189:Aryl Hydrocarbon Hydroxylases