Generation and elimination of angiotensins I and II in the kidney, liver and lung.
Inflow and outflow concentrations of angiotensins I (AI) and II (AII) from both kidneys, the liver and the lung were measured in 30 hypertensive patients, the majority having lateralization of the renin secretion. In the renin secreting kidney the data indicated a high generation rate of AI. In the contralateral kidney and splanchnic region both AI and AII were 'eliminated', and in the lungs the results confirmed previous evidence of converting enzyme activity.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000803:Angiotensin I / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism*; D000809:Angiotensins / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D012084:Renin-Angiotensin System
D000809:Angiotensins; D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A