title: Clinical evaluation of cefotiam (CGP/14221) versus cephalothin in the treatment of urinary tract infections.
abstract: A study was carried out in 35 patients with urinary tract infections to compare the efficacy and tolerance of cefotiam and cephalothin. Patients received at random either 1 g cefotiam twice daily (19 patients) or 1 g cephalothin 4-times daily (16 patients) parenterally over a period of 10 days. Therapeutic efficacy was assessed mainly on disappearance of bacteriuria. Only 1 patient of those receiving cefotiam failed to respond and suffered a delayed relapse. Five patients failed to respond to cephalothin: in 3 of them bacteriuria persisted throughout treatment and there was relapse in the other 2 patients. The time for the disappearance of bacteriuria was significantly shorter in the cefotiam group.
mesh_terms: D000328:Adult; D000368:Aged; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015310:Cefotiam; D002512:Cephalothin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D015310:Cefotiam; D002439:Cefotaxime; D002512:Cephalothin