title: Increased sensitivity of cerebrohepatorenal syndrome fibroblasts to antimycin A.
abstract: The effect of four mitochondrial electron transport inhibitors on the growth of normal and cerebrohepatorenal syndrome (CHRS) fibroblasts was studied. Compared to normal fibroblasts, CHRS cells demonstrated a fivefold greater sensitivity to antimycin A, an inhibitor of the cytochrome bc1 complex (complex III), but equal inhibition by amytal, rotenone and 2-heptyl-4-hydroxyquinoline-N-oxide. The results suggest a primary or secondary functional deficiency at mitochondrial complex III in fibroblasts.
mesh_terms: D000968:Antimycin A / Q000494:pharmacology*; D001921:Brain / Q000002:abnormalities*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D014450:Electron Transport Complex III; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D007223:Infant; D007668:Kidney / Q000002:abnormalities*; D008103:Liver Cirrhosis / Q000151:congenital*; D008928:Mitochondria / Q000201:enzymology; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000172:deficiency*; D009247:NADH, NADPH Oxidoreductases / Q000172:deficiency*; D011808:Quinone Reductases / Q000037:antagonists & inhibitors / Q000172:deficiency*; D013577:Syndrome
chemical_list: D009097:Multienzyme Complexes; D000968:Antimycin A; D009247:NADH, NADPH Oxidoreductases; D011808:Quinone Reductases; D014450:Electron Transport Complex III