Dissociation between behavioral effects of (-)-N-(2-chloroethyl)-norapomorphine and D2 dopamine receptor-like activity.
Low doses of d-amphetamine (1.0 mg/kg) can reduce the spontaneous hyperactivity of BALB/cJ mice. Amphetamine-induced hypolocomotion can be antagonized by NCA and sulpiride pretreatment, suggesting that this is a dopaminergic phenomenon. However, behaviorally active doses of NCA do not alter brain D2 dopamine receptor binding in either mice or rats. NCA also did not induce stereotypy/catalepsy or affect apomorphine-induced stereotypy. The results suggest that another type of dopamine receptor may mediate the behavioral effects of amphetamine and NCA.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001060:Aporphines / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects*; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D001060:Aporphines; D011942:Receptors, Adrenergic, alpha; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; C025935:chloroethylnorapomorphine; D001058:Apomorphine; D003913:Dextroamphetamine