title: [In vitro study of macrophage barrier function in mice vaccinated against tick-borne encephalitis and infection with flaviviruses of varying virulence].
abstract: Tick-borne encephalitis (TBE) and Langat viruses were shown to be equally capable of multiplication in mouse peritoneal macrophages (PM) in vitro. The reproduction dynamics of TBE virus proved to be the same in PM of mice both highly sensitive and relatively less sensitive to TBE virus. The preliminary immunization of PM donors with commercial inactivated or experimental concentrated TBE virus vaccine produced no effect on the capacity of the virus for multiplication in PM. These facts indicate the absence of correlation between the capacity of the viruses under study for multiplication in PM in vitro and their virulence in vivo, as well as the insignificant role of circulating macrophages in the realization of the barrier function in an immune or nonimmune body.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid; D002478:Cells, Cultured; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology* / Q000472:pathogenicity; D004675:Encephalitis, Tick-Borne / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010587:Phagocytosis; D014036:Togaviridae Infections / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage*; D014774:Virulence
chemical_list: D014765:Viral Vaccines
vernacular_title: Issledovanie in vitro bar'ernoĭ funktsii makrofagov mysheĭ pri vaktsinatsii protiv kleshchevogo éntsefalita i infektsii flavivirusami s razlichnoĭ virulentnost'iu.