Transferability of tetracycline resistance to Clostridium perfringens isolated from human feces.
118 strains of Clostridium perfringens isolated from human fecal specimens were examined for sensitivity to tetracycline. Minimum inhibitory concentrations of tetracycline were more than 50 micrograms/ml for 18 strains and less than 3.1 micrograms/ml for 54 strains. Tetracycline resistance transfer experiments were carried out using 18 tetracycline-resistant strains as donors and 54 drug-sensitive strains as recipients. 14 of 18 tetracycline-resistant strains transferred their resistance to at least 1 recipient, and 48 of 54 tetracycline-sensitive strains accepted tetracycline resistance from at least 1 donor strain.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003016:Clostridium perfringens / Q000187:drug effects* / Q000235:genetics; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011815:R Factors; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013752:Tetracycline