Formation of N-nitrosodiphenylamine from 1,1-diphenylhydrazine by rat liver microsomal preparations.
The present study provides the first evidence for in vitro metabolic conversion of a 1,1-disubstituted hydrazine to the corresponding nitrosamine. The study shows that superoxide radical which is generated by NADPH-cytochrome c reductase is involved in the oxidation of 1,1-diphenylhydrazine to N-nitrosodiphenylamine catalyzed by rat liver microsomes.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism; D005609:Free Radicals; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism*; D010084:Oxidation-Reduction; D010659:Phenylhydrazines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013481:Superoxides / Q000378:metabolism
D002273:Carcinogens; D005609:Free Radicals; D009602:Nitrosamines; D010659:Phenylhydrazines; D013481:Superoxides; C023649:N-nitrosodiphenylamine; C037220:1,1-diphenylhydrazine; D009251:NADPH-Ferrihemoprotein Reductase