GABAB receptor-mediated stimulation of the contractility of isolated rabbit oviduct.
The effects of gamma-aminobutyric acid (GABA) and related compounds were examined on longitudinal and circular muscle preparations isolated from oviducts of virgin rabbits. GABA and baclofen stimulated the spontaneous motility in each type of preparation, which action could not be antagonized by bicuculline, phentolamine, atropine or tetrodotoxin. Muscimol was virtually ineffective. Our results indicate the presence of GABAB receptors in the rabbit oviductal musculature which mediate the contractile response.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D005187:Fallopian Tubes / Q000187:drug effects / Q000502:physiology*; D005260:Female; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D011817:Rabbits; D011956:Receptors, Cell Surface / Q000502:physiology*; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D001418:Baclofen