The effects of beta-(Tyr9)melanotropin-(9-18) and H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH on the analgesic action of morphine.
beta-(Tyr9)melanotropin-(9-18), which itself has no analgesic action, as measured by the tail-flick and hot-plate methods, decreased morphine-induced analgesia following intracerebroventricular injection. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH heptapeptide, which has weak CRF-like activity, had no action on analgesia and was not able to modify morphine-induced analgesia. Compared with ACTH1-24, which in a subcutaneous dose of 100 micrograms/rat decreased morphine-induced analgesia, the same dose of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was ineffective.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000698:Analgesia; D000818:Animals; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats
D009842:Oligopeptides; D010446:Peptide Fragments; C033533:MSH, beta, (9-18), Tyr(9)-; D009020:Morphine; C036810:H-phenylalanyl-isoleucyl-tyrosyl-histidyl-seryl-tyrosyl-lysine; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones