Effect of 3-acetylpyridine on the content of myelin in the rat brain.
Ten-week old rats were fed an AIN-76 purified die ad libitum and were given 3-acetylpyridine which is an antagonistic agent of nicotinic acid. The quantity and composition of myelin in the brain were analyzed after administration of 3-acetylpyridine for 40 days. Body weight, myelin yield, cerebroside level and specific activity of 2',3'-cyclic nucleotide-3'-phosphohydrolase in the brain decreased by administration of 3-acetylpyridine. Despite the decreased myelin yield, the proportion of protein and total lipid and the percentage composition of lipid in myelin did not change by administration of 3-acetylpyridine. Therefore, we have concluded that 3-acetylpyridine plays a significant role in the loss of myelin.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002554:Cerebrosides / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D009185:Myelin Proteins / Q000378:metabolism*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002554:Cerebrosides; D009185:Myelin Proteins; D011725:Pyridines; C010835:3-acetylpyridine; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases