title: Interval appearance of glioblastomas not evident in previous CT examinations.
abstract: This communication presents our experience with eight patients who were initially evaluated as having normal cerebral computed tomographic (CT) scans. Follow-up scans ranging from 2 to 9 months later showed interval appearance of large contrast enhancing mass producing lesions. All eight of these patients turned out to have glioblastoma multiforme. This phenomenon of "false-negative" CT does not seem to be dependent on the type of equipment used or the age of the patient. Negative CT should not dissuade radiologists and clinicians from believing that a patient with appropriate symptoms and signs does indeed harbor a brain tumor.
mesh_terms: D000367:Age Factors; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002648:Child; D005188:False Negative Reactions; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014057:Tomography, X-Ray Computed