Desensitization of ornithine decarboxylase activity to norepinephrine in the testis of rat.
Injection of norepinephrine (NE) at a dose of 10 micrograms per testis caused the testis refractory in terms of ornithine decarboxylase (ODC) activity at 24 h. This desensitization was found to be both time and dose dependent. Injection with follicle stimulating hormone, luteinizing hormone, prostaglandin F2 alpha, cyclic AMP or epinephrine to norepinephrine desensitized testis caused stimulation of ODC activity. This indicates that the refractoriness caused by norepinephrine is specific to this agent alone.
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology; D015237:Dinoprost; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
D011460:Prostaglandins F; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D015237:Dinoprost; D000242:Cyclic AMP; D009955:Ornithine Decarboxylase; D009638:Norepinephrine; D004837:Epinephrine