title: Influence of adrenocorticotropic hormone on the growth of isolated neurons in culture.
abstract: The present study reports the influence of adrenocorticotropic hormone (ACTH) on the development of cultured neurons from chick embryo cerebral hemispheres. Cultures were initiated in serum-supplemented medium and then transferred to serum-free hormonally-defined medium containing various concentrations of ACTH1--24. The effects of ACTH on the light microscopic features, metabolic activity and permeation properties were examined. The results demonstrate that ACTH exerts a trophic action on the neurons.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects; D002642:Chick Embryo; D003366:Cosyntropin / Q000494:pharmacology*; D046508:Culture Techniques; D009474:Neurons / Q000166:cytology / Q000187:drug effects
chemical_list: D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone