Presynaptic effect of streptomycin on the insect neuromuscular junction.
The effect of streptomycin on the neuromuscular junction of the cockroach leg muscle was studied by means of intracellular electrodes. The miniature excitatory postsynaptic potential (MEPSP) frequency decreased in the presence of 1 mM streptomycin. Double logarithmic plots of the quantal content against the external calcium concentration in the absence and presence of streptomycin suggested the competition for a common site of presynaptic membrane at insect neuromuscular junctions.
D000818:Animals; D002118:Calcium / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects*; D010526:Periplaneta; D013307:Streptomycin / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D002118:Calcium; D013307:Streptomycin