[Evaluation of the analgesic activity of a soluble precursor of aspirin in orthopedic surgery].
We carried out a randomized double-blind trial to evaluate the analgesic effect, rapidity of action and tolerance of calcium carbasalate relative to a placebo, given in a single dose of 1 gr. aspirin equivalent immediately after an orthopedic surgical procedure. Autoevaluation by the patient using a visual scale and overall evaluation of analgesic effectiveness by the patient and relatives showed that pain was significantly less with the active therapy whose tolerance was excellent.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation; D014508:Urea / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000700:Analgesics; D014508:Urea; C002942:carbaspirin calcium; D001241:Aspirin
Evaluation de l'activité antalgique d'un précurseur soluble de l'aspirine en chirurgie orthopédique.