Receptor for ATP in the membrane of mammalian sensory neurones.
ATP-activated conductance has been found in a large number of neurones isolated from various sensory ganglia of the rat and cat. The inward current produced by ATP (Kd = 5 x 10(-6) M) is carried by cations and demonstrates rapid activation and slow desensitization. The sequence of agonists (ATP greater than ADP with AMP and adenosine ineffective) is different from those previously described for purinergic receptors P1 and P2.
D000255:Adenosine Triphosphate / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D002413:Cations, Divalent / Q000378:metabolism; D002415:Cats; D002462:Cell Membrane / Q000032:analysis; D002463:Cell Membrane Permeability; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D007474:Ion Exchange; D009475:Neurons, Afferent / Q000032:analysis* / Q000502:physiology; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000502:physiology; D011983:Receptors, Purinergic
D002413:Cations, Divalent; D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate