Peripheral nerve injury by chymopapain injection.
Chymopapain injected into the intervertebral disc space (chemonucleolysis) has been used clinically in patients with disc disease with success. Neurosurgical complications secondary to the procedure have, however, been reported. In this study, the authors have investigated the possible neurotoxic effect of chymopapain on the peripheral nerve in rat and primate models. While the extrafascicular injection caused no nerve fiber damage, the intrafascicular injection caused dose-related nerve fiber damage in both species.
D000818:Animals; D002917:Chymopapain / Q000008:administration & dosage / Q000009:adverse effects*; D010450:Endopeptidases / Q000009:adverse effects*; D007267:Injections; D008297:Male; D008954:Models, Biological; D010215:Papio; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000473:pathology
D010450:Endopeptidases; D002917:Chymopapain