The effect of bis-pyridinium oximes on neuromuscular blockade induced by highly toxic organophosphates in rat.
Two bispyridinium oximes, BDB-27 and HGG-12, were tested in vivo for their ability to restore neuromuscular function in rats poisoned by 1.3 LD50 of sarin, soman, tabun and XV, using isolated phrenic nerve-diaphragm preparation. Their effectiveness was evaluated in comparison with the two most potent oximes in this respect, HI-6 and TMB-4. It was found that BDB-27 was equal or superior to HI-6 in sarin, soman and XV and to TMB-4 in tabun poisoned animals. Recovery of function after HGG-12 was equal to HI-6 only in soman poisoning, but much less pronounced against neuromuscular blockade induced by the other three anticholinesterases. The results point at the equal effectiveness of BDB-27 in functional recovery in poisoning by all four toxic agents tested, so far not encountered by any other oxime.
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D002802:Cholinesterases / Q000378:metabolism; D007928:Lethal Dose 50; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D009943:Organophosphorus Compounds / Q000633:toxicity*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission
D000931:Antidotes; D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D011726:Pyridinium Compounds; C020165:HGG 12; C038261:BDB 27; D002802:Cholinesterases