[Modification of the gating mechanism of incurrent sodium channels by an osmotic pressure gradient on a perfused neuron].
The influence of the osmotic pressure gradient was investigated by the voltage clamp method. It was shown that the osmotic gradient changed both activation and inactivation of the sodium conductivity and decreased the sodium current amplitude. Conductivity of single sodium channels was not affected by the osmotic pressure gradient. It is concluded that the decrease in sodium current amplitude is due to a decrease in the number of open channels.
D000818:Animals; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009997:Osmotic Pressure; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D012668:Trigeminal Ganglion / Q000166:cytology
D007473:Ion Channels; D012964:Sodium
Modifikatsiia gradientom osmoticheskogo davleniia na membrane perfuzirovannogo neĭrona vorotnogo mekhanizma kanalov natrievogo vkhodiashchego toka.