Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells.
Hygromycin B, a preferential translation inhibitor in virus-infected cells, has been tested for its antiviral effects against herpes simplex virus type 2 and poliovirus. The activity has been compared with other antiviral agents such as vidarabine and iododeoxyuridine.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D006921:Hygromycin B / Q000494:pharmacology*; D017955:Poliovirus / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D006921:Hygromycin B