title: Is there a general paradigm of cyclic AMP action in eukaryotes?
abstract: The cyclic AMP control system in eukaryotes has been highly conserved evolutionarily in four of its central properties. Such conservation suggests conservation of the regulatory function of cyclic AMP. Conservation is seen in the properties of adenylate cyclase, cyclic AMP-dependent protein kinase and, among diverse lower eukaryotes, the control of endogenous cyclic AMP levels. A conserved regulatory response to cyclic AMP is the stimulation of glycolysis and inhibition of gluconeogenesis. The control of glycolysis and gluconeogenesis is proposed to be evidence of general pattern of cyclic AMP action in many lower and higher eukaryotic cells.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D005075:Biological Evolution; D050260:Carbohydrate Metabolism; D002468:Cell Physiological Phenomena; D000242:Cyclic AMP / Q000502:physiology*; D004926:Escherichia coli / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology*; D005943:Gluconeogenesis; D006019:Glycolysis; D008970:Molecular Weight; D011494:Protein Kinases / Q000502:physiology
chemical_list: D000242:Cyclic AMP; D011494:Protein Kinases; D000262:Adenylyl Cyclases