Dansylcadaverine eliminates calmodulin stimulation of phosphodiesterase.
Dansylcadaverine, which structurally resembles the calmodulin antagonists W-7 and W-5, prevented the calmodulin dependent stimulation of 3':5'-cyclic nucleotide phosphodiesterase in vitro. Dansylcadaverine and trifluoperazine sensitized cells to Pseudomonas aeruginosa exotoxin A in apparently the same way, exept that 40 times higher concentrations of dansylcadaverine than of trifluoperazine was required.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism*; D036002:ADP Ribose Transferases; D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D001427:Bacterial Toxins; D002103:Cadaverine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002147:Calmodulin / Q000494:pharmacology*; D002417:Cattle; D002460:Cell Line; D006224:Cricetinae; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D003959:Diamines; D005098:Exotoxins / Q000494:pharmacology; D007668:Kidney / Q000201:enzymology; D011433:Propranolol / Q000494:pharmacology; D014268:Trifluoperazine / Q000494:pharmacology; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
D015105:3',5'-Cyclic-AMP Phosphodiesterases; D036002:ADP Ribose Transferases; D000639:Amitriptyline; D001427:Bacterial Toxins; D002103:Cadaverine; D002147:Calmodulin; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D003959:Diamines; D005098:Exotoxins; D011433:Propranolol; D014268:Trifluoperazine; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A; C008542:monodansylcadaverine