Decreased natural killer activity in patients with liver cirrhosis.
Natural killer (NK) activity of peripheral blood mononuclear cells from patients with non-alcoholic liver cirrhosis (LC) (30 cases), patients with other, non-malignant diseases (41 cases), and healthy subjects (36 cases) were investigated using 51Cr-labelled CCRF-CEM and K562 target cells. NK activity in patients with LC was lower than that in healthy subjects and that in patients with other, non-malignant diseases. The differences were statistically significant by Student's t-test and the Wilcoxon rank test. There was no difference of NK activity between serologically hepatitis B surface antigen (HBsAg)-positive and -negative patients.
D000328:Adult; D000367:Age Factors; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D002460:Cell Line; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008103:Liver Cirrhosis / Q000276:immunology*; D008113:Liver Neoplasms / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D011336:Probability; D012737:Sex Factors
D006514:Hepatitis B Surface Antigens