Cutaneous cytodestructive potency of lignans. II. A comparative evaluation of macroscopic-toxic influence on rabbit skin subsequent to repeated 10-day applications.
Four lignans: podophyllotoxin (A), 4'-demethyl-podophyllotoxin (B), alpha-peltatin (C), and beta-peltatin (D) are the podophyllin ingredients producing lesional necrosis after application on condylomata acuminata. This study evaluates comparatively their destructive potency on rabbit skin after 10-day repeated applications. Any visible changes or increase on skinfold thickness induced by each of the drugs tested as 0.01, 0.05, 0.1, and 0.5% ethanolic preparations were followed. These variables demonstrated a close covariation; the analyses revealed a significant difference with respect to influence on measurements according to the following ranking order: A greater than C greater than D = B.
D000287:Administration, Topical; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000378:metabolism; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007700:Kinetics; D017705:Lignans; D009336:Necrosis; D010936:Plant Extracts / Q000008:administration & dosage* / Q000378:metabolism; D011034:Podophyllotoxin / Q000008:administration & dosage / Q000378:metabolism; D011817:Rabbits; D012867:Skin / Q000473:pathology*; D012885:Skinfold Thickness
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts; D011034:Podophyllotoxin