title: Multiple sclerosis: effect of gamma linolenate administration upon membranes and the need for extended clinical trials of unsaturated fatty acids.
abstract: Electrophoretic mobility studies of red blood cells from subjects with multiple sclerosis indicate that treatment with unsaturated fatty acids must continue for at least 2 years before normal reactivity is restored by currently available tests. If this applies to myelin also, then clinical trials aimed at treating the recognized multiple sclerosis subject by polyunsaturated fatty acids really begin after 2 years, and this should be recognized when a trial program is drawn up.
mesh_terms: D000293:Adolescent; D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000627:therapeutic use; D004586:Electrophoresis; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006801:Humans; D008042:Linolenic Acids / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D017965:gamma-Linolenic Acid
chemical_list: D001095:Arachidonic Acids; D008042:Linolenic Acids; D016718:Arachidonic Acid; D017965:gamma-Linolenic Acid