A murine model of polymyositis induced by coxsackievirus B1 (Tucson strain).
A murine model of polymyositis induced by coxsackievirus B1, Tucson strain (CVBT) is described. Intraperitoneal CVBT inoculation of CD 1 Swiss mice less than 48 hours old resulted in proximal hindquarter weakness that was first apparent 7 days after viral challenge and persisted for more than 10 weeks. Electromyographic and histologic evidence of a continuing myositis was present during this entire period of time. However, virus was not detectable later than 2 weeks post infection, despite clinical progression of disease. The finding of electromyographic and histologic abnormalities in CVBT-infected mice, long after virus had cleared and neutralizing antibody production evoked, suggests that persistent myositis may be immunologically mediated, triggered by the initial acute viral infection.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001327:Autoimmune Diseases / Q000382:microbiology; D003384:Coxsackievirus Infections / Q000150:complications* / Q000473:pathology; D004195:Disease Models, Animal; D004576:Electromyography; D029822:Enterovirus B, Human / Q000276:immunology; D051379:Mice; D009220:Myositis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology
D000914:Antibodies, Viral; D000956:Antigens, Viral