Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.
A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.
D000755:Anemia, Sickle Cell / Q000235:genetics*; D002874:Chromosome Mapping; D004262:DNA Restriction Enzymes / Q000235:genetics; D005787:Gene Frequency; D005799:Genes, Dominant; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D009136:Muscular Dystrophies / Q000235:genetics*; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D004262:DNA Restriction Enzymes