3-PPP antagonizes the in vitro effects of D-1 and D-2 dopamine receptor agonists in rat neostriatum.
3-PPP has been reported to be a selective dopamine autoreceptor agonist, a conclusion based on in vivo studies. In rat neostriatum in vitro however, 3-PPP antagonized concentration-dependently the stimulation of cyclic AMP efflux caused by the D-1 receptor agonist SKF 38393 and the inhibition of K+-induced [3H]acetylcholine release caused by the D-2 receptor agonist LY 141865. 3-PPP alone did not affect [3H]acetylcholine release or cyclic AMP efflux. When interpreting the effects of 3-PPP in vivo dopamine receptor antagonism should be considered.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*
D010880:Piperidines; D011954:Receptors, Dopamine; C026539:preclamol; D000242:Cyclic AMP; D000109:Acetylcholine