Effects of cholecystokinin-related peptides on retention of passive avoidance behaviour.
Effects of intraperitoneal administration of cholecystokinin (CCK)-related peptides were studied on retention of single-trial learning passive avoidance behaviour. The COOH-terminal octapeptide of CCK (CCK-1-8-SE), the unsulfated octapeptide (CCK-1-8-NS), as well as the COOH-terminal tetrapeptide of CCK (CCK-5-8), administered immediately after the learning trial, facilitated passive avoidance behaviour. The data indicate that these peptides may influence memory consolidation processes.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005755:Gastrins / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D012844:Sincalide / Q000494:pharmacology; D013758:Tetragastrin / Q000494:pharmacology*
D005755:Gastrins; D010446:Peptide Fragments; D013758:Tetragastrin; D002766:Cholecystokinin; D012844:Sincalide