Effect of intratracheal lignocaine, halothane and thiopentone on changes in plasma beta-endorphin immunoreactivity in response to tracheal intubation.
Alterations in the concentration of plasma beta-endorphin immunoreactivity (beta-EPir), in response to the stress of tracheal intubation, were measured in 48 women during halothane anaesthesia. The increase in plasma beta-EPir in response to tracheal intubation could be prevented by topical analgesia (4% lignocaine 2 ml) to the trachea, a deeper level of halothane anaesthesia (1.5%) and an increased dose of thiopentone (10 mg kg-1). It was concluded that a low plasma beta-EPir value is a sign of stress-free anaesthesia and that measurements of plasma beta-EPir may be useful in determining the degree of stress present during various anaesthetic procedures.
D000287:Administration, Topical; D000328:Adult; D000768:Anesthesia, General; D004723:Endorphins / Q000097:blood*; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007442:Intubation, Intratracheal; D010535:Laparoscopy; D007813:Laparotomy; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D011863:Radioimmunoassay; D013312:Stress, Physiological / Q000503:physiopathology; D013874:Thiopental / Q000494:pharmacology*; D001615:beta-Endorphin
D004723:Endorphins; D001615:beta-Endorphin; D008012:Lidocaine; D013874:Thiopental; D006221:Halothane