Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor.
The predicted amino acid sequence of the simian sarcoma virus (SSV) transforming gene product, p28sis, closely corresponds to that of human platelet-derived growth factor (PDGF). We demonstrate that p28sis rapidly undergoes a series of discrete processing steps including dimer formation and proteolytic digestion to yield molecules structurally and immunologically resembling biologically active PDGF.
D000595:Amino Acid Sequence; D005814:Genes, Viral; D006801:Humans; D007700:Kinetics; D008970:Molecular Weight; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D011499:Protein Processing, Post-Translational; D012190:Retroviridae / Q000235:genetics*; D012842:Sarcoma Virus, Woolly Monkey / Q000235:genetics*; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000235:genetics* / Q000302:isolation & purification
D010982:Platelet-Derived Growth Factor; D014764:Viral Proteins