title: Light and electron microscopic studies on the cytological changes in the rat pancreatic islets induced by sodium diethyl dithiocarbamate (DEDTC) administration.
abstract: The effect of sodium diethyl dithiocarbamate ( DEDTC ) administration upon the structure of the pancreatic islet cells has been examined in the rat. In light microscopy, the aldehyde fuchsin stainability of the B cell granules was found to increase notably at 6 h and thereafter following the medication. In electron microscopy, the B cell granules with a porous core were shown to predominate over those with a homogeneous core containing paracrystalline structures between 30 min and 3 h following the medication. Between 6 and 12 h following medication, occasional B cells were seen to be provided with large secretory granules with a porous core. The results of the present study have been discussed with special reference to the chelating action of DEDTC .
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000187:drug effects; D004050:Ditiocarb / Q000633:toxicity*; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013859:Thiocarbamates / Q000633:toxicity*
chemical_list: D013859:Thiocarbamates; D004050:Ditiocarb