title: Small cell bronchogenic carcinoma: factors associated with pneumonia during chemotherapy.
abstract: Sixty-five patients with small cell bronchogenic carcinoma were treated with intensive induction chemotherapy and supportive treatment. The clinical course of 43 patients who had pretreatment spirometry and arterial blood gases was studied. Thirteen patients developed pneumonia. Moderate hypoxemia, advanced age, and a low forced expiratory flow 25%-75% were associated with the development of pneumonia. Endobronchial obstruction and neutropenia, other factors associated with infection in cancer patients, appeared to be less important in this patient population.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001853:Bone Marrow / Q000187:drug effects; D002283:Carcinoma, Bronchogenic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D018288:Carcinoma, Small Cell / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005540:Forced Expiratory Flow Rates; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011014:Pneumonia / Q000209:etiology*; D011379:Prognosis; D012044:Regression Analysis; D012306:Risk
chemical_list: D010100:Oxygen