Phorbol ester receptors: autoradiographic identification in the developing rat.
Autoradiography with 3H-labeled phorbol dibutyrate was used for the light microscopic detection of phorbol ester receptors in rat fetuses. In 15- and 18-day fetuses, as well as in adult rats, receptors were found to be concentrated in the central nervous system. The localization of receptors in the ventral marginal zone of the fetal neural tube, the lens of the eye, and other sites suggests a role for phorbol ester receptors in cellular process extension and cell-cell interaction.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000196:embryology; D001923:Brain Chemistry; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D002450:Cell Communication; D002455:Cell Division; D002490:Central Nervous System / Q000032:analysis / Q000196:embryology*; D005123:Eye / Q000196:embryology; D005333:Fetus / Q000032:analysis*; D007422:Intestines / Q000196:embryology; D007908:Lens, Crystalline / Q000196:embryology; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000378:metabolism*; D010704:Phorbols / Q000378:metabolism*; D011493:Protein Kinase C; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000032:analysis*; D011955:Receptors, Drug
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D010703:Phorbol Esters; D010704:Phorbols; D011956:Receptors, Cell Surface; D011955:Receptors, Drug; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C