title: Prenatal cytomegalovirus disease and cerebral microgyria: evidence for perfusion failure, not disturbance of histogenesis, as the major cause of fetal cytomegalovirus encephalopathy.
abstract: From the study of four personal cases of microgyria related to fetal CMV infection and a review of the literature it is concluded that: 1) Microgyria is a frequent neuropathological finding in this disease - 2) CMV microgyria is the result of an insufficiency of cerebral blood supply and is not due to a disturbance of neurogenesis or histogenesis as a consequence of a direct cytopathic effect of the virus on germinal cells. The way by which the CMV causes cerebral ischemia - angeitis or more probably, transient systemic perfusion failure, - is discussed, but remains obscure. Other viruses may act on the fetal brain by way of circulatory disturbances.
mesh_terms: D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D001927:Brain Diseases / Q000151:congenital* / Q000196:embryology / Q000209:etiology / Q000473:pathology; D002545:Brain Ischemia / Q000151:congenital / Q000209:etiology / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital* / Q000196:embryology; D005260:Female; D005315:Fetal Diseases; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy