Dopamine depletion in nucleus accumbens reduces ACTH1-24-induced excessive grooming.
Animals were pretreated with 6-OHDA or ascorbate vehicle injected into the nucleus accumbens and tested 10 days later for excessive grooming induced by intracerebroventricular injection of ACTH1-24. The animals pretreated with 6-OHDA showed a significant decrease in excessive grooming produced by the neuropeptide and this reduction was seen only in the last 30 minutes of a 60-min test session. The results suggest an interaction of ACTH with dopamine systems on the onset and maintenance of excessive grooming.
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D003366:Cosyntropin / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D006120:Grooming / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000187:drug effects*; D013997:Time Factors
D006892:Hydroxydopamines; D003366:Cosyntropin; D016627:Oxidopamine; D000324:Adrenocorticotropic Hormone; D004298:Dopamine