title: Morphometric investigations into the mechanism of the compensatory hypertrophy of the rat adrenal zona fasciculata after unilateral adrenalectomy.
abstract: Compensatory hypertrophy of the remaining gland in unilaterally adrenalectomized rats was investigated by morphometric techniques. It was observed that compensatory adrenal growth occurred in both dexamethasone-treated and hypophysectomized rats, receiving maintenance doses of ACTH. However, it was only half that found in intact animals. These results support the view that activation of the hypothalamo-hypophyseal axis is not the unique mechanism underlying adrenal compensatory hypertrophy in the rat.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology*; D000315:Adrenalectomy; D000308:Adrenocortical Hyperfunction / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D007016:Hypophysectomy; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D051381:Rats
chemical_list: D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone