Effect of adrenalectomy and dexamethasone treatment on testicular enzymes involved in carbohydrate metabolism.
The effect of adrenalectomy on specific activities of testicular hexokinase, 6-phosphofructokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glycogen concentration have been studied. A general increase in specific activities of all enzymes was seen after adrenalectomy in rats of all ages studied. However, lactate dehydrogenase activity and glycogen concentration in pre-pubertal rats alone were depleted with no alteration in pubertal and adult animals. This was accompanied by increased prolactin titres, but gonadotrophins and testosterone were unaltered. Dexamethasone treatment returned all enzyme activities and hormonal profiles to normal.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D050260:Carbohydrate Metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006062:Gonadotropins / Q000097:blood; D006728:Hormones / Q000097:blood; D008297:Male; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects / Q000201:enzymology*
D006062:Gonadotropins; D006728:Hormones; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase