Novel biological property of pertussis toxin: chemotactic activity on human monocytes.
Pertussis toxin isolated from Bordetella pertussis phase I strain Tohama enhanced the migration of human blood monocytes in an assay with a multiwell chemotaxis assembly. The monocyte migration enhancement by pertussis toxin was abolished by heating at 100 degrees C for 30 min, which caused a complete loss of the other biological activities of pertussis toxin. Checkerboard analysis demonstrated that the increased monocyte migration caused by pertussis toxin was directed toward a positive stimulus: chemotaxis.
D001427:Bacterial Toxins / Q000494:pharmacology*; D001886:Bordetella pertussis; D002634:Chemotaxis, Leukocyte; D006358:Hot Temperature; D006801:Humans; D009000:Monocytes / Q000502:physiology; D037342:Pertussis Toxin; D010566:Virulence Factors, Bordetella
D001427:Bacterial Toxins; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin