title: Maternally derived immune resistance to fatal diarrhea in infant mice due to mouse hepatitis virus.
abstract: Adult female ICR mice were able to produce high titered neutralizing antibodies to mouse hepatitis virus (MHV) by repeated intraperitoneal injections of formalin-inactivated virus. Offspring sucklings born to the immunized dams resisted to MHV causing fatal diarrhea, when their dams had a complement fixing antibody titer of 1:5 or higher. The protection was found to be mediated mainly through neutralizing IgG antibodies in the milk. Sucklings from non-immune dams were also protected by foster-nursing by immune mothers.
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D000914:Antibodies, Viral / Q000032:analysis; D003967:Diarrhea / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D005260:Female; D006524:Hepatitis, Viral, Animal; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007774:Lactation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D006517:Murine hepatitis virus / Q000276:immunology*; D011247:Pregnancy
chemical_list: D000914:Antibodies, Viral