title: Regional localization of two human cellular Kirsten ras genes on chromosomes 6 and 12.
abstract: Human cellular Kirsten ras1 and ras2 genes were localized to chromosomes 6p23 ----q12 and 12p12 .05----pter, respectively, using human-rodent cell hybrids. Thus, the short arms of human chromosomes 11 (encoding lactate dehydrogenase-A and the proto-oncogene c-Ha- ras1 ) and 12 (encoding lactate dehydrogenase B and c-Ki- ras2 ) share at least two pairs of genes that probably evolved from common ancestral genes.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D006224:Cricetinae; D003412:Cricetulus; D004262:DNA Restriction Enzymes; D005347:Fibroblasts / Q000502:physiology; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000235:genetics; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D000090063:Proto-Oncogene Mas
chemical_list: D007527:Isoenzymes; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D007770:L-Lactate Dehydrogenase; D004262:DNA Restriction Enzymes