Anti-mutagenic chalcones: antagonizing the mutagenicity of benzo(a)pyrene on Salmonella typhimurium.
Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 - 700 times stronger than that of L-ascorbic acid. Effect on other mutagens, the structure activity relationship and the possible mechanism of action are briefly discussed.
D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000037:antagonists & inhibitors*; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000037:antagonists & inhibitors*; D011427:Propiophenones / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics; D013329:Structure-Activity Relationship
D001580:Benzopyrenes; D009153:Mutagens; D011427:Propiophenones; D001564:Benzo(a)pyrene; D002599:Chalcone