[Effect of cholecystokinin octapeptide on brain monoamine levels during feeding and drinking motivational excitation].
The paper presents studies of the influence of octapeptide cholecystokinin (ChCK-8) on the level of dofamine, noradrenaline and serotonine in the hypothalamus, septum, amygdala, striatum and mesencephalon of the rats brain during 24-, 48- and 96-hour alimentary and water deprivation. A change of catecholamines content under the influence of ChCK-8 was observed for the most part in conditions of thirst and only in the hypothalamus. ChCK-8 action in conditions of water deprivation was selective and directed mainly to the restoration of the changes in transmitter's level. ChCK-8 did not have a significant influence on the level of the brain monoamines during hunger. It may be assumed, that "satiation" hormone ChCK-8 is to a great extent connected with the mechanisms of reinforcement, and its "satiating" effect would appear at catecholamines' level in the process of satisfying of corresponding need.
D000818:Animals; D001479:Basal Ganglia / Q000032:analysis; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000032:analysis; D005508:Food Deprivation / Q000502:physiology*; D008032:Limbic System / Q000032:analysis; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D012844:Sincalide / Q000494:pharmacology*; D014868:Water Deprivation / Q000502:physiology*
D001679:Biogenic Amines; D012701:Serotonin; D012844:Sincalide; D004298:Dopamine; D009638:Norepinephrine
Vliianie oktapeptida kholetsistokinina na uroven' monoaminov mozga v usloviiakh pishchevogo i pit'evogo motivatsionnykh vozbuzhdeniĭ.