Specific suppression of human T lymphocyte function by leukotriene B4.
Leukotriene B4, but not leukotrienes C4, D4, E4, or 12(S)-leukotriene B4, inhibited in a concentration-dependent manner the capacity of PHA-stimulated human T lymphocytes to generate LIF activity and to proliferate, as assessed by the uptake of [3H]thymidine.
D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D007975:Leukotriene B4 / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013189:SRS-A / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects*
D007961:Leukocyte Migration-Inhibitory Factors; D010835:Phytohemagglutinins; D013189:SRS-A; D007975:Leukotriene B4