GABA uptake by human blood platelets: effects of lithium and rubidium chlorides.
The methodologic and kinetic characteristics of GABA uptake by platelets were determined in blood platelets of volunteer donors. Extrapolation of a reciprocal plot indicate two uptake systems: a high affinity and a passive diffusion mechanism. When LiCl and RbCl were added in vitro, they had no effect on platelet GABA uptake. Our data suggest that platelet GABA and 5-HT uptake are carried out by different systems.
D000328:Adult; D001693:Biological Transport, Active / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology*; D004058:Diffusion; D005260:Female; D006801:Humans; D007700:Kinetics; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D008875:Middle Aged; D012413:Rubidium / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000097:blood / Q000378:metabolism*
D002712:Chlorides; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D008094:Lithium; D018021:Lithium Chloride; D012413:Rubidium; C032710:rubidium chloride