Influence of chronic administration of ciclazindol on energy balance and brown adipose tissue in adult 'cafeteria'-fed rats.
The effects of chronic oral administration of ciclazindol on energy balance and brown adipose tissue (BAT) activity were studied in adult rats maintained on a palatable cafeteria diet. Treatment with 1 mg ciclazindol/kg/day produced small, but not significant, reductions in body energy gain and increases in BAT mass and protein content. Administration of 3.4 and 11 mg/kg/day of ciclazindol depressed weight gain and caused a substantial (42%) reduction in body energy gain. These effects were partly due to a lower food intake, but also resulted from a marked decrease in energetic efficiency. Rats treated with 3.4 and 11 mg/kg/day of the drug showed significant increases in BAT protein content, Na+, K+-ATPase activity and mitochondrial proton conductance, assessed from GDP-binding capacity. These results show that the reduced body weight produced by ciclazindol is due to a lower energetic efficiency, which is associated with activation of BAT, and also a depressed food intake.
D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004734:Energy Metabolism / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013997:Time Factors
D001786:Blood Glucose; D007211:Indoles; D007328:Insulin; D000254:Sodium-Potassium-Exchanging ATPase; C009990:ciclazindol