Monoclonal antibodies that inhibit attachment of group B coxsackieviruses.
Hybridoma cell lines that secrete monoclonal antibodies which react with HeLa cell surface antigens were produced. The monoclonal antibodies prevented cytopathic effects caused by coxsackievirus B1 and significantly reduced the amounts of coxsackieviruses B1, B5, and B6 that absorb to HeLa cells. These antibodies did not protect the cells from poliovirus cytopathic effects, and they had no effect on the attachment of other picornaviruses to HeLa cells.
D000042:Absorption; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D003588:Cytopathogenic Effect, Viral; D029822:Enterovirus B, Human / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D006825:Hybridomas; D051379:Mice; D010849:Picornaviridae / Q000502:physiology; D011991:Receptors, Virus / Q000276:immunology*; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D011991:Receptors, Virus