Gene product of v-fgr onc: hybrid protein containing a portion of actin and a tyrosine-specific protein kinase.
The nucleotide sequence of the region of Gardner-Rasheed feline sarcoma virus (GR-FeSV) encoding its primary translation product, p70gag-fgr, has been determined. From the nucleotide sequence, the amino acid sequence of this transforming protein was deduced. Computer analysis indicates that a portion of P70gag-fgr has extensive amino acid sequence homology with actin, a eukaryotic cytoskeletal protein. A second region of P70gag-fgr is closely related to the tyrosine-specific kinase gene family. Thus, the v-fgr oncogene appears to have arisen as a result of recombinational events involving two distinct cellular genes, one coding for a structural protein and the other for a protein kinase.
D000199:Actins / Q000032:analysis; D000595:Amino Acid Sequence; D001483:Base Sequence; D003201:Computers; D015683:Gene Products, gag; D005814:Genes, Viral; D009857:Oncogenes; D011494:Protein Kinases / Q000032:analysis; D011505:Protein-Tyrosine Kinases; D011995:Recombination, Genetic; D012190:Retroviridae / Q000235:genetics*; D005253:Sarcoma Viruses, Feline / Q000235:genetics*; D014764:Viral Proteins / Q000032:analysis / Q000235:genetics*
D000199:Actins; D015683:Gene Products, gag; D014764:Viral Proteins; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases