Non-specific antiviral activity of bovine leukocytes against infectious bovine rhinotracheitis virus in vitro.
Leukocytes collected from bovine blood inhibit the multiplication of virus in IBR infected MDBK cells. This inhibition is non-specific and can be observed in the absence of serum. Number of infected cells, number of leukocytes per infected cell and time of placing of leukocytes onto infected cells are some of the important factors in this protection. We observed variations between animals, but for each animal the activity of leukocytes was constant for several months. Contact between leukocytes and the susceptible cell is a vital factor in this protection. We could not detect any soluble mediator in the supernatant fluid. The different types of cells which constitute the population of leukocytes are less efficient than the original heterogenous population (80% lymphocytes and 20% neutrophils and monocytes).
D000818:Animals; D002417:Cattle / Q000276:immunology*; D003588:Cytopathogenic Effect, Viral; D007242:Herpesvirus 1, Bovine / Q000472:pathogenicity*; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007962:Leukocytes / Q000276:immunology* / Q000382:microbiology; D013997:Time Factors; D014776:Virus Cultivation