Anti-botulismic effect of toosendanin and its facilitatory action on miniature end-plate potentials.
The time for blocking neuromuscular transmission by botulinum toxin is lengthened in phrenic nerve-diaphragm preparation of rats sacrificed at various times after subcutaneous injection of toosendanin (7 mg/kg). This effect of toosendanin manifests itself 15 min after injection and lasts for 3 days. During this period the frequency of miniature end-plate potentials is increased.
D000200:Action Potentials; D000818:Animals; D001904:Botulinum Antitoxin; D004365:Drugs, Chinese Herbal; D009045:Motor Endplate / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors; D014315:Triterpenes
D001904:Botulinum Antitoxin; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C036454:toosendanin; D014315:Triterpenes