[Prevention of functional impairments of cardiac muscle mitochondria in emotional-painful stress].
In experiments with 216 male rats emotional-painful stress impaired distinctly the oxidative phosphorylation and Ca2+ transport in heart muscle mitochondria. When gamma-hydroxybutyric acid, inderal, antioxidants ionol and isoptin were used as selective inhibitors of definite steps in the pathogenetic chain of stress heart impairments, these impairments of the mitochondrial functions were effectively prevented at the step of regulatory mechanisms responsible for the stress reactions.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006801:Humans; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010146:Pain / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012508:Sarcolemma / Q000378:metabolism; D012978:Sodium Oxybate / Q000494:pharmacology*; D013315:Stress, Psychological / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D006885:Hydroxybutyrates; D007473:Ion Channels; D012978:Sodium Oxybate; D011433:Propranolol; D014700:Verapamil; D002118:Calcium
Preduprezhdenie narusheniĭ funktsii mitokhondriĭ serdechnoĭ myshtsy pri émotsional'no-bolevom stresse.