Similarities between cytomegalovirus-induced cell rounding and contraction of smooth muscle cells.
Cytomegalovirus infection of human fibroblastic cell cultures resulted in rounding of the cells and a subsequent decrease in their size. Smooth muscle relaxing agents such as papaverine, hydralazine, diazoxide, nitroprusside and verapamil blocked these early cytopathogenic effects suggesting that cell rounding results from a contractile-like response involving an influx of calcium ions.
D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000473:pathology; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D003981:Diazoxide / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D006830:Hydralazine / Q000494:pharmacology; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000166:cytology* / Q000473:pathology; D009599:Nitroprusside / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D009599:Nitroprusside; D006830:Hydralazine; D014700:Verapamil; D010208:Papaverine; D003981:Diazoxide