Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen.
The glomerular basement membrane antigen in Goodpasture syndrome is a collagenase-resistant molecule with a monomer molecular weight of about 26,000. Type IV collagen isolated from glomerular basement membrane contains collagenase-resistant sequences within its structure. Polyacrylamide gel electrophoresis, enzyme-linked immunosorbent assay, and chemical analysis were used to demonstrate that the collagenase-resistant sequences of type IV collagen contain Goodpasture antigen.
D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology; D003094:Collagen / Q000276:immunology*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology*; D003012:Microbial Collagenase / Q000378:metabolism; D008970:Molecular Weight
D003094:Collagen; D003012:Microbial Collagenase