Comparison of the influence of the opiate delta receptor antagonist, ICI 154,129, and naloxone on social interaction and behaviour in an open field.
The influence of a novel opiate delta receptor antagonist, ICI 154,129, and naloxone on social interaction and on behaviour in an open field were compared. At a dose thought to optimally block the delta receptor, ICI 154,129 produced open field behaviour typical of a non-emotional animal: this drug decreased social investigation and the latency to attack. In contrast, naloxone was largely without effect in these tests.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007398:Interpersonal Relations; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects*; D017465:Receptors, Opioid, delta
D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D009270:Naloxone; D004743:Enkephalin, Leucine; C036405:ICI 154129