Failure of naloxone or beta-endorphin to affect pressure-induced tremor in guinea pig.
Naloxone in doses up to 2 mg/kg and beta-endorphin in doses up to 1 mg/kg had no suppressive effect on pressure-induced tremor or cortical EEG activity in the guinea pig. The lack of effect of either naloxone or beta-endorphin on the HPNS provides evidence that opiate receptor mechanisms are not significantly involved in this syndrome.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D004723:Endorphins / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011312:Pressure / Q000009:adverse effects; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D014202:Tremor / Q000188:drug therapy* / Q000209:etiology; D001615:beta-Endorphin
D004723:Endorphins; D011957:Receptors, Opioid; D009270:Naloxone; D001615:beta-Endorphin