Thymic carcinoid tumor with Cushing's syndrome. Report of a case with electron microscopic and immunoperoxidase studies for neuron-specific enolase and corticotropin.
A partially encapsulated, 11-cm-diameter anterior mediastinal mass was resected from a 26-year-old man who appeared with signs and symptoms of Cushing's syndrome. Electron microscopic study disclosed cytoplasmic neurosecretory granules and positive immunoperoxidase reactions for neuron-specific enolase and corticotropin in the tumor cells. A lymph node metastasis was detected 11/2 years after the operation. It appears that a thymic carcinoid tumor is a specific entity.
D048948:14-3-3 Proteins; D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D000328:Adult; D002276:Carcinoid Tumor / Q000150:complications* / Q000473:pathology; D003480:Cushing Syndrome / Q000150:complications*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D009419:Nerve Tissue Proteins / Q000032:analysis*; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology; D014446:Tyrosine 3-Monooxygenase
D048948:14-3-3 Proteins; D009419:Nerve Tissue Proteins; D000324:Adrenocorticotropic Hormone; D014446:Tyrosine 3-Monooxygenase