Comparison of miconazole- and ketoconazole-induced release of K+ from Candida species.
Relatively high concentrations of miconazole caused immediate and rapid release of K+ from strains of Candida albicans and Can. parapsilosis. Ketoconazole did not. These results support the recent hypothesis that ketonocazole, unlike related antifungal imidazole-containing drugs, cannot exert a direct membrane damaging effect.
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D007654:Ketoconazole; D008825:Miconazole / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*
D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D008825:Miconazole; D007654:Ketoconazole; D011188:Potassium