Transient focal liver scan defects in children receiving chemotherapy (pseudometastases). Work in progress.
Three pediatric patients with tumors (two rhabdomyosarcoma, one Wilms tumor) had significant focal defects on Tc-99m sulfur colloid scans while receiving chemotherapy (all three had received chemotherapy, including actinomycin D, within ten days prior to scanning). In all three, the defects resolved spontaneously; one biopsy showed fibrosis of a mild degree. The finding of defects on liver scans of pediatric patients receiving chemotherapy must not be automatically assumed to be metastatic disease; the changes may relate to hepatic response to recently administered chemotherapy.
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008297:Male; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D011877:Radionuclide Imaging; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy; D009396:Wilms Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy*