The fatty acid composition of 1,2-diacylglycerol and polyphosphoinositides from human erythrocyte membranes.
The fatty acid compositions of 1,2-diacylglycerol and polyphosphoinositides have been determined in human erythrocyte membranes that have been incubated in the presence or in the absence of Ca2+. The results show that the diacylglycerol that is formed in Ca2+-treated membranes has a fatty acid composition closely similar to that of the inositides, consistent with previous indications that Ca2+ stimulates the activity of a polyphosphoinositide phosphodiesterase in the membranes. In contrast with some previous results, it appears that these plasma-membrane inositides and their derived diacylglycerols are rich in stearic acid and arachidonic acid.
D002118:Calcium / Q000494:pharmacology; D004075:Diglycerides / Q000097:blood*; D004910:Erythrocyte Membrane / Q000032:analysis* / Q000187:drug effects; D004912:Erythrocytes / Q000032:analysis*; D005227:Fatty Acids / Q000097:blood*; D005989:Glycerides / Q000097:blood*; D006801:Humans; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000097:blood*
C011439:1,2-diacylglycerol; D004075:Diglycerides; D005227:Fatty Acids; D005989:Glycerides; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D002118:Calcium