title: Effects of low doses of gamma radiation on DNA synthesis in the developing rat brain.
abstract: Rats of one or ten days of age were irradiated with low doses of gamma radiation, and synthesis of DNA was examined by the incorporation of 3H-thymidine in the cerebellum and the rest of the brain in vivo. DNA synthesis was depressed in both parts of the brain but the effects were larger in cerebellum. A minimum was found about 10 hours after irradiation in the older rats and later (18 h) in the younger ones. The dose response, in 10-day-old rats, was biphasic and showed that cerebellum was more affected. Autoradiographs showed that fewer cells entered the cycle and those synthesizing showed a depressed rate of synthesis. These findings are discussed in relation to induction of cell death.
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D002531:Cerebellum / Q000378:metabolism / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000009:adverse effects*; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D003037:Cobalt Radioisotopes; D004247:DNA