Interaction of thymopoietin peptides with the specific receptor of facteur thymique serique (FTS).
The capacity of ubiquitin (UB) and thymopoietin II (TP) related peptides (TP 5 and TP 13) to interfere with the specific binding of [3H]FTS on intact 1301 cells or on 1301 plasma membrane preparations was studied. All 3 peptides significantly inhibited the binding of [3H]FTS to its receptors on intact 1301 cells at concentrations 20 to 100 times higher than FTS itself. Conversely, none of the 3 peptides provided a significant inhibition of the specific [3H]FTS binding to plasma membrane preparations of 1301 cells compared to control peptides. These contrasted results suggest that TP-related peptides and, to a lesser degree, UB may share the same target cells with FTS and interfere with FTS effects on T cells, but this interaction probably does not involve direct high affinity binding to the FTS receptors.
D000818:Animals; D001667:Binding, Competitive; D002417:Cattle; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011971:Receptors, Immunologic; D016305:Thymopentin; D013946:Thymopoietins / Q000378:metabolism*; D013951:Thymus Hormones / Q000378:metabolism*; D014452:Ubiquitins
D002868:Chromosomal Proteins, Non-Histone; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D013946:Thymopoietins; D013951:Thymus Hormones; D014452:Ubiquitins; C033482:serum thymic factor receptor; D004743:Enkephalin, Leucine; C032841:thymopoietin III; D005934:Glucagon; D016305:Thymopentin