Influence of D-galactosamine upon the NAD-metabolism in rat liver.
After application of D-galactosamine a hepatitis develops in the rat liver. This can be prevented by different agents, including tryptophan. Yet it has not been possible to give definitive conclusions about the mechanism of galactosamine hepatitis. In this paper we report about the influence of galactosamine on the NAD metabolism. D-galactosamine inhibits the NAD synthesis initiated by nicotinamide in normal and adrenalectomized animals. The NAD synthesis from tryptophan is prevented in normal animals, in adrenalectomized ones however there is an increase of NAD in the presence of D-galactosamine reduces the activity of the ADPR transferase. Inhibitors of the ADPR transferase prevent the galactosamine hepatitis. From the results presented we conclude that the ADPR transferase plays an important role in the development of the galactosamine hepatitis.
D000315:Adrenalectomy; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D005688:Galactosamine / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008715:Methionine / Q000494:pharmacology; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000031:analogs & derivatives / Q000494:pharmacology; D009713:Nucleotidyltransferases / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases; D051381:Rats; D011919:Rats, Inbred Strains; D014364:Tryptophan
D009243:NAD; D009536:Niacinamide; D005688:Galactosamine; D014364:Tryptophan; D008715:Methionine; D011065:Poly(ADP-ribose) Polymerases; D009713:Nucleotidyltransferases; C024058:N(1)-methylnicotinamide