[Antibiotic prevention in gynecology. Concentrations of ceftizoxime in the serum, myometrium, endometrium and fallopian tubes].
34 patients received an intravenous bolus injection of 2 g ceftizoxime over 5 min at various times before abdominal or vaginal hysterectomy. Ceftizoxime concentrations in myometrium were substantially higher than in salpinges and endometrium. Tissue concentrations of 4 micrograms/g could be maintained for at least 3 hours. The ceftizoxime tissue concentrations attained in myometrium, endometrium and salpinges justify therapeutic studies and controlled prospective clinical trials on the prevention of postoperative wound infections with this antibiotic.
D000328:Adult; D000368:Aged; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D015296:Ceftizoxime; D004717:Endometrium / Q000032:analysis*; D005187:Fallopian Tubes / Q000032:analysis*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009215:Myometrium / Q000032:analysis*; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors
D015296:Ceftizoxime; D002439:Cefotaxime
Antibiotikaprophylaxe in der Gynäkologie. Konzentrationen von Ceftizoxim in Serum, Myometrium, Endometrium und Tuben.