[Beta-adrenergic mechanism of the radio-protective effect of isoproterenol in a mammalian cell culture].
A specific beta-agonist, isoproterenol, increased the intracellular content of cyclic AMP and decreased the radiosensitivity of Chinese hamster fibroblasts. Beta-antagonist, propranolol, blocked the manifestation of the effect of isoproterenol. Isoproterenol did not affect either the intracellular level of cyclic AMP or the radiosensitivity of B-82 cells which had no beta-adrenoreceptors.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D000242:Cyclic AMP / Q000378:metabolism; D005347:Fibroblasts; D007545:Isoproterenol / Q000494:pharmacology*; D007739:L Cells / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D011433:Propranolol / Q000494:pharmacology; D011837:Radiation-Protective Agents; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D011837:Radiation-Protective Agents; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D000242:Cyclic AMP; D007545:Isoproterenol
Beta-adrenergicheskiĭ mekhanizm protivoluchevogo deĭstviia izoproterenola na kul'turu kletok mlekopitaiushchikh.