Treatment of Salmonella carriers with pivmecillinam alone or in combination with pivampicillin: experience with three patients.
3 patients with salmonella infections who continued to excrete salmonella in fecal samples for more than 6 months were treated with pivmecillinam alone or in combination with pivampicillin. Mecillinam alone cured 1 of the carriers, but was without success in the 2 others. One of these patients was cured after treatment with pivmecillinam and pivampicillin. In the last patient salmonella excretion ceased after treatment with pivmecillinam, pivampicillin and probenecid. The choice of treatment was based upon in vitro demonstration of synergism between mecillinam and ampicillin. In the last patient the final treatment was chosen after studies of the bactericidal effect of the patient's serum during various regimes.
D000328:Adult; D000561:Amdinocillin Pivoxil / Q000008:administration & dosage / Q000627:therapeutic use*; D000667:Ampicillin / Q000031:analogs & derivatives*; D001770:Blood Bactericidal Activity; D002353:Carrier State / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010397:Penicillanic Acid / Q000627:therapeutic use*; D010917:Pivampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D012475:Salmonella / Q000187:drug effects; D012480:Salmonella Infections / Q000188:drug therapy*
D010917:Pivampicillin; D000561:Amdinocillin Pivoxil; D000667:Ampicillin; D010397:Penicillanic Acid