title: [Improved technology of culturing Bordetella pertussis based on a study of the kinetics of the process].
abstract: The article deals with the study of the kinetics of the processes occurring in the population of B. pertussis grown in a semisynthetic culture medium. On the basis of the mathematical description of the specific growth rate the factors permitting the regulation of the processes of the cultivation of B. pertussis have been revealed. New prolonged multicyclic combined exponential and continuous processes of the cultivation of B. pertussis have been worked out and introduced into practice. These processes are important for the improvement of the modern technology of obtaining B. pertussis biomass, suitable for the production of prophylactic preparations.
mesh_terms: D001431:Bacteriological Techniques; D001886:Bordetella pertussis / Q000254:growth & development* / Q000276:immunology; D003470:Culture Media / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008433:Mathematics; D010567:Pertussis Vaccine / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D003470:Culture Media; D010567:Pertussis Vaccine
vernacular_title: Sovershenstvovanie tekhnologii kul'tivirovaniia kokliushnykh bakteriĭ na osnove izucheniia kinetiki protsessov.