Effect of acyclovir on viral protein synthesis in cells infected with herpes simplex virus type 1.
The effect of the antiviral agent 9-(2-hydroxyethoxymethyl)guanine (acyclovir) on herpes simplex virus type 1 protein synthesis during virus replication was examined. Treatment of infected cells with acyclovir markedly affected the amounts of the four major glycosylated and certain non-glycosylated viral polypeptides synthesized; other viral polypeptides were made in normal amounts. The reduced amount of late protein synthesis was most likely due to the inhibition of progeny viral DNA synthesis by acyclovir.
D000212:Acyclovir / Q000494:pharmacology*; D004279:DNA, Viral / Q000096:biosynthesis; D006023:Glycoproteins / Q000096:biosynthesis; D018139:Simplexvirus / Q000187:drug effects* / Q000378:metabolism; D014764:Viral Proteins / Q000096:biosynthesis*
D004279:DNA, Viral; D006023:Glycoproteins; D014764:Viral Proteins; D000212:Acyclovir