[Reduced production of superoxide (02(-)] in peritoneal macrophages of the rat submitted to acute alcoholic intoxication].
Acute ethanol administration by intragastric tube caused an impairment of the superoxide anion production by rat peritoneal macrophages as compared to controls. Since the oxidative-dependent microbicidal system plays a crucial role, at cellular level, in the host defence mechanisms, this work may explain, at last in part, the reduced resistence of alcoholics to infections.
D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D004072:Digitonin / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013481:Superoxides / Q000378:metabolism*
D013481:Superoxides; D004072:Digitonin
Ridotta produzione di superossido (o-2) nei macrofagi peritoneali di ratto sottoposto ad intossicazione alcolica acuta.