Transcription in vivo of an Alu family member upstream from the human epsilon-globin gene.
The more distal Alu repeat flanking the epsilon-globin gene is transcribed in K562 cells to generate transcripts 350-400 nucleotides in length. Initiation occurs at the start of the repeat, upstream of a putative PolIII control signal. These transcripts originate from the strand which does not code epsilon-globin and are oriented in the opposite direction from the gene. They are non-polyadenylated, nucleus-confined and are only detectable in association with expression of the epsilon-globin gene.
D002460:Cell Line; D003062:Codon; D004720:Endonucleases; D005796:Genes; D005914:Globins / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D008214:Lymphocytes / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D015719:Single-Strand Specific DNA and RNA Endonucleases; D014158:Transcription, Genetic
D003062:Codon; D005914:Globins; D004720:Endonucleases; D015719:Single-Strand Specific DNA and RNA Endonucleases