title: A role of renal K+-stimulated phosphatase activity on elevation of urinary sodium excretion in fluoride-treated rats.
abstract: Fluoride administered to nonfasted rats caused an elevation of urinary sodium excretion but not an increased urinary potassium excretion as previously observed by one of us in fasted rats. This elevated urinary sodium excretion was associated with decreased renal K+-stimulated phosphatase activity. The decreased phosphatase activity was reversed by treatment with aldosterone, but not by treatment with prednisolone.
mesh_terms: D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D005459:Fluorides / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008861:Microsomes / Q000201:enzymology; D009318:Natriuresis / Q000187:drug effects*; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D011188:Potassium / Q000494:pharmacology / Q000652:urine; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology
chemical_list: D000450:Aldosterone; D012969:Sodium Fluoride; D011239:Prednisolone; D010744:Phosphoric Monoester Hydrolases; D008274:Magnesium; D005459:Fluorides; D011188:Potassium