Sensitivity of equine herpesviruses 1 and 3 in vitro to a new nucleoside analogue, 9-[[2-hydroxy-1-(hydroxymethyl) ethoxy] methyl] guanine.
The following members of the Herpetoviridae family were tested to determine their sensitivities to the new antiviral drug, BIOLF-62: equine herpesvirus types 1 and 3, human herpesvirus types 1 and 2, swine herpesvirus, bovine herpesvirus type 4, feline herpesvirus, canine herpesvirus, and herpes simiae virus. Equine herpesviruses 1 and 3, human herpesviruses 1 and 2, and herpes simiae virus were all sensitive to BIOLF-62 at concentrations of less than 0.55 micrograms/ml. Equine herpesvirus types 1 and 3 were particularly sensitive, viral median effective dose (ED50) concentrations of the drug being only 0.033 and 0.16 micrograms/ml, respectively. Such high antiviral potency and low cell toxicity indicate that BIOLF-62 might be useful in the treatment of infected animals.
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002415:Cats; D002417:Cattle; D004285:Dogs; D015774:Ganciclovir; D006564:Herpesviridae / Q000187:drug effects*; D004861:Herpesvirus 1, Equid / Q000187:drug effects*; D006736:Horses / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D012867:Skin / Q000187:drug effects
D000998:Antiviral Agents; D015774:Ganciclovir; D000212:Acyclovir