The stability of the hippocampal slice preparation: an electrophysiological and ultrastructural analysis.
The viability and stability of the in vitro rat hippocampal slice preparation were assessed using electrophysiological and electron microscopical means. Slices exhibited lifetimes of 6-19 h. Correlation between the duration of electrical activity and changes in ultrastructure of these slices was found. Possible reasons for the wide variability in lifetime of the hippocampal slice are suggested.
D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D008854:Microscopy, Electron; D009410:Nerve Degeneration; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology; D009435:Synaptic Transmission; D013997:Time Factors