title: Translational inhibition of heat-shock induced gene expression in picornavirus-infected Drosophila melanogaster cells.
abstract: Picornavirus infection of Drosophila melanogaster cells inhibited the appearance of heat-shock induced proteins. Examination of intracellular mRNAs revealed that those coding for heat shock proteins were present in a translationally competent form in infected cells. Inhibition of induced gene expression in infected Drosophila cells therefore involves, but is not necessarily solely mediated by, effects at the level of translation.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004331:Drosophila melanogaster / Q000235:genetics; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000235:genetics*; D010850:Picornaviridae Infections / Q000235:genetics*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
chemical_list: D006360:Heat-Shock Proteins; D012333:RNA, Messenger; D014764:Viral Proteins