title: Main mechanisms of therapeutic action in atopic asthma in children.
abstract: Immunological disorders are clearly demonstrated in children suffering from the atopic form of bronchial asthma, namely increase in the levels of total and specific IgE and a decrease in the number of T cells. Specific hyposensitization produces, in addition to a good clinical effect, an immunomodulating action which is not restricted to the formation of blocking antibodies but is displayed also by T cell stimulation. Our studies revealed a reduction in the level of prostaglandins E and increase in the content of prostaglandins F-2 as well as a decrease in the cAMP levels in blood serum and urine in the period free of attacks; the demonstrated effect of Euphylline, Intal and Zaditen on these values confirms the expediency of introducing these agents into the therapeutic complex.
mesh_terms: D000628:Aminophylline / Q000627:therapeutic use; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004205:Cromolyn Sodium / Q000627:therapeutic use; D000242:Cyclic AMP / Q000032:analysis; D003888:Desensitization, Immunologic; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007223:Infant; D007665:Ketotifen / Q000627:therapeutic use; D008407:Mast Cells / Q000276:immunology; D011458:Prostaglandins E / Q000032:analysis; D011460:Prostaglandins F / Q000032:analysis; D012463:Saliva / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007071:Immunoglobulin A, Secretory; D011458:Prostaglandins E; D011460:Prostaglandins F; D000628:Aminophylline; D007073:Immunoglobulin E; D000242:Cyclic AMP; D004205:Cromolyn Sodium; D007665:Ketotifen