Methods using tissue preparations and isolated biomolecules.
The possibility to use organs, organelle preparations and biologically active chemicals in toxicity tests and in toxicology will be reviewed. Examples are perfused liver preparations, tissue slices and homogenates, isolated nerve preparations, nerve-muscle preparations, membrane preparations, microsomes, mitochondria, synaptosomes, antibodies and isolated chemical compounds (receptors, enzymes).
D000818:Animals; D001921:Brain / Q000187:drug effects; D002490:Central Nervous System / Q000502:physiology; D004557:Electric Organ / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D014116:Toxicology / Q000379:methods*