Improvement of the absorption of 3H-Cholecalciferol by formation of its cyclodextrin complex.
Following oral administration to rats of beta-cyclodextrin inclusion complex of 3H-labelled vitamin D3 (cholecalciferol) resulted in significantly higher blood radioactivity as with the non-complexed vitamin. Difference in the first 90 min was 2,3-2,8 fold, and it remained significantly higher up to the 6th h. After 24 h there was no difference between the blood radioactivity of animals treated with complexed and with non-complexed vitamin D3.
D002762:Cholecalciferol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D003505:Cyclodextrins / Q000008:administration & dosage; D006801:Humans; D007408:Intestinal Absorption; D013997:Time Factors
D003505:Cyclodextrins; D002762:Cholecalciferol