[Erythrocyte filtrability in liver cirrhosis].
In view of the frequent erythrocyte abnormalities found in liver cirrhosis, erythrocyte deformability was studied in 62 patients. Deformability was determined by the initial filtration flow technique using a Hemorheometer. Results are given as a rigidity index (IR), which is characteristic of the average individual RBC. Deformability was significantly reduced in patients with cirrhosis. No correlation was found with the often increased MCV. A significant positive correlation was found between IR and the cell membrane free cholesterol/phospholipid ration, as the increase in cell rigidity is mainly due to a decrease in the cell membrane sphingomyelin content. The role of reduced RBC deformability in liver cirrhosis anemia still awaits elucidation.
D004909:Erythrocyte Indices; D004910:Erythrocyte Membrane / Q000032:analysis; D004912:Erythrocytes / Q000502:physiology*; D004913:Erythrocytes, Abnormal / Q000032:analysis; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012794:Sialic Acids / Q000097:blood; D014462:Ultrafiltration
D008055:Lipids; D012794:Sialic Acids
La filtrabilité érythrocytaire dans les cirrhoses du foie.