"Bolus" methylprednisolone versus ACTH in the treatment of multiple sclerosis.
Two groups of 30 multiple sclerosis (MS) patients were randomly treated with corticotrophin (ACTH) and "bolus" 6-methylprednisolone (B/6-MP) to compare the effectiveness of the two treatments. Both ACTH and B/6-MP showed a similar effect, improving acute neurological deficits of MS patients without modifying the long term course of the disease. B/6-MP, showing prompt effectiveness and lack of side effects, may be regarded as a useful alternative to conventional treatment of MS.
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage*; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D014677:Pharmaceutical Vehicles; D011897:Random Allocation
D014677:Pharmaceutical Vehicles; D000324:Adrenocorticotropic Hormone; D008775:Methylprednisolone