Effects of base exchange reaction on the Na+, K+ ATPase in rat brain microsomes.
Incorporation of ethanolamine and monomethylethanolamine into their corresponding phospholipid by the base exchange enzymes activated an Na+, K+-ATPase associated with a rat brain microsomes enriched preparation. The serine and dimethylethanolamine base exchange catalyzed incorporation reactions inhibited this particular Na+, K+-ATPase. These effects require Ca2+ and several other structural analogues which are not incorporated into phospholipid were without affect on this ATPase.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002118:Calcium / Q000494:pharmacology; D003642:Deanol / Q000494:pharmacology; D004983:Ethanolamines / Q000494:pharmacology; D008861:Microsomes / Q000201:enzymology*; D019884:Nitrogenous Group Transferases; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014166:Transferases / Q000494:pharmacology*
D004983:Ethanolamines; D003642:Deanol; D014166:Transferases; D019884:Nitrogenous Group Transferases; C022370:phospholipid serine base exchange enzyme; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium; C017500:N-methylaminoethanol