title: The effects of increased extracellular potassium in the isolated spinal cord on the flexor reflex of the frog.
abstract: The effects of superfusing the isolated frog spinal cord with various concentrations of K+ on flexor reflexes were examined. The reflexes were evoked by pinching or by electrical stimulation. An increase in [K+]e from 2 to 6 mmol/l facilitates the flexor reflex. Higher [K+]e produces inhibition. It is suggested that the increase in [K+]e which may occur under physiological conditions facilitates the impulse transmission, and that larger increases in [K+]e which likely occur only under extreme conditions, result in inhibition.
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D011188:Potassium / Q000008:administration & dosage*; D011896:Rana temporaria; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D011188:Potassium