The influence of the kappa-agonist bremazocine on ingestive behaviour in mice and rats.
The effects of bremazocine on drinking and eating behaviour were studied in non-deprived mice and 12 hr food and water deprived rats. In both species, bremazocine (1-8 mg/kg) produced substantial increase in fluid intake (dose-dependent in rats). The concomitant alterations of food intake were less pronounced and opposite: increase in mice, decrease in rats. Morphine (1.25-10.0 mg/kg) invariably inhibited eating and drinking behaviour in mice. The afore-said effects of the kappa-receptor agonist bremazocine are not affected by naloxone which attenuates the effects of the mu-receptor agonist morphine.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001575:Benzomorphans / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009019:Morphinans / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D013045:Species Specificity
D000700:Analgesics; D001575:Benzomorphans; D009019:Morphinans; D011957:Receptors, Opioid; C027248:bremazocine