title: Transferability of tetracycline resistance to Clostridium perfringens isolated from human feces.
abstract: 118 strains of Clostridium perfringens isolated from human fecal specimens were examined for sensitivity to tetracycline. Minimum inhibitory concentrations of tetracycline were more than 50 micrograms/ml for 18 strains and less than 3.1 micrograms/ml for 54 strains. Tetracycline resistance transfer experiments were carried out using 18 tetracycline-resistant strains as donors and 54 drug-sensitive strains as recipients. 14 of 18 tetracycline-resistant strains transferred their resistance to at least 1 recipient, and 48 of 54 tetracycline-sensitive strains accepted tetracycline resistance from at least 1 donor strain.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003016:Clostridium perfringens / Q000187:drug effects* / Q000235:genetics; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011815:R Factors; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013752:Tetracycline