Steroids and idiopathic facial paralysis.
The face proclaims to the world an individual's identity and as such is the most conspicuous part of his anatomy. No wonder, then, that idiopathic facial paralysis is a frightening experience for the patient. Ever since it was first noted, all manners of measures have been used to bring about early and full recovery. Unfortunately, none of these treatments is effective. Following Rothendler's case description in 1951, a multitude of papers have appeared, evaluating the effectiveness of steroids in idiopathic facial paralysis. This article evaluates 92 of these papers. Only a few properly controlled, randomized prospective studies were available. Their main conclusion was that steroid treatment was not more beneficial than conventional treatment. But several less valid prospective and retrospective studies have suggested that steroid treatment is beneficial. The definitive, statistically valid study of the benefits of steroids in treating has yet to be performed. Until then steroid treatment of this condition will continue to be controversial.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use*; D005158:Facial Paralysis / Q000188:drug therapy*; D006801:Humans; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D011278:Pregnanes / Q000627:therapeutic use*; D011446:Prospective Studies; D012189:Retrospective Studies
D011278:Pregnanes; D000324:Adrenocorticotropic Hormone; D011241:Prednisone