title: Restoration of the nicotinic receptor-channel activity from the blockade by atropine in bullfrog sympathetic ganglia.
abstract: Atropine (3 microM) reduced both the nicotinic and muscarinic acetylcholine (ACh) potentials of the bullfrog sympathetic ganglion cell. However, the former was completely restored within 1 h during a sustained exposure to atropine, while the latter remained blocked. Similar restorations were observed for the depressant effects on both the amplitude and decay phase of a nerve-induced postsynaptic current. The results suggest that the sustained or repetitive binding of atropine to this site results in a new conformational state capable of passing ions almost normally, but resistant to the blockade by atropine.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects*; D011892:Rana catesbeiana; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology*
chemical_list: D007473:Ion Channels; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D001285:Atropine; D000109:Acetylcholine