Low renal uptake of 99mTc-DMSA in patients with proximal tubular dysfunction.
In nine patients with different types of proximal tubulopathy and a nearly normal glomerular filtration rate a low uptake of 99mTc-DMSA in kidneys was found. The underlying mechanism seems to be an increased urinary excretion of 99mTc-DMSA. This radiopharmaceutical might be used as a marker of proximal tubular dysfunction.
D000293:Adolescent; D002648:Child; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007668:Kidney / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D007687:Kidney Tubules, Proximal; D011877:Radionuclide Imaging; D004113:Succimer; D013438:Sulfhydryl Compounds; D013667:Technetium; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
D013438:Sulfhydryl Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D013667:Technetium; D004113:Succimer