Antitumor activity of acidic mannan fraction from bakers' yeast.
The acidic fraction of bakers' yeast mannan containing mannose (93.6%), nitrogen (1.0%), and phosphorus (0.6%), designated as WAM025, showed a marked antitumor activity against the ascites forms of Ehrlich, sarcoma 180 and Meth A tumors in vivo. Namely, a 100% survival of mice transplanted with Ehrlich or sarcoma 180 ascites tumor, 1 X 10(5) cells/ddY strain mouse, was obtained by the intraperitoneal administration of WAM025, 150 mg/kg/d for 10 d. This effect evoked by WAM025 seems to be attributed to the activation of peritoneal adherent cells in mice, because a significant elevation of lysosomal enzyme level and active oxygen generation was observed on the peritoneal adherent cells obtained from the mannan-administered mice.
D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002448:Cell Adhesion; D002478:Cells, Cultured; D006861:Hydrogen Peroxide / Q000378:metabolism; D008163:Luminescent Measurements; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008351:Mannans / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010100:Oxygen / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000032:analysis / Q000502:physiology*; D012510:Sarcoma 180 / Q000188:drug therapy; D013481:Superoxides / Q000378:metabolism
D000970:Antineoplastic Agents; D008351:Mannans; D013481:Superoxides; D006861:Hydrogen Peroxide; D010100:Oxygen