title: M-current in voltage-clamped olfactory cortex neurones.
abstract: The soma of olfactory cortex neurones in vitro was voltage-clamped by means of a single microelectrode sample-and-hold technique. In most neurones, hyperpolarizing voltage commands from relatively positive holding potentials (-40 to -50 mV) elicited a slow inward current relaxation with voltage-dependent and kinetic properties similar to the non-inactivating K+-current (M-current; IM), first described in amphibian sympathetic neurons. Deactivation of IM at negative potentials probably accounts for the slow sag of the hyperpolarizing electrotonic potential measured during current-clamp experiments. IM was inhibited by the cholinergic agonist muscarine or barium ions.
mesh_terms: D000818:Animals; D001464:Barium / Q000494:pharmacology; D002463:Cell Membrane Permeability; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology; D008032:Limbic System / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009116:Muscarine / Q000494:pharmacology; D009833:Olfactory Pathways / Q000502:physiology; D011188:Potassium / Q000494:pharmacology
chemical_list: D007473:Ion Channels; D001464:Barium; D009116:Muscarine; D011188:Potassium