In vivo assessment of 99mTc-labeled hematoporphyrin derivative in tumor-bearing animals.
The efficacy of 99mTc-labeled hematoporphyrin derivative in localizing neoplasms has been investigated with tumor-bearing animal models. Spontaneous mammary adenocarcinomas of outbred CFW strain Swiss-Webster white mice and chemical carcinogen induced breast tumors in female Sprague-Dawley white rats were clearly visualized in the scintigrams. Mice tissue distribution data demonstrate favourable tumor to organ ratios sufficiently high to permit tumor detection. [99mTc]HPD appears promising as a tumor imaging agent.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000556:secondary; D005260:Female; D017324:Hematoporphyrin Derivative; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008321:Mammary Glands, Animal; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000000981:diagnostic imaging; D008665:Metalloporphyrins; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000662:veterinary; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium
D008665:Metalloporphyrins; D015609:Organotechnetium Compounds; C040432:technetium Tc 99m hematoporphyrin derivative; D015127:9,10-Dimethyl-1,2-benzanthracene; D017324:Hematoporphyrin Derivative; D013667:Technetium