Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol.
1. Neither cannabichromene (CBC) nor delta 9-tetrahydrocannabinol (THC) protected mice from electroshock-induced seizures, although THC inhibited postictal mortality. Minor effects were produced on seizure latency and duration. 2. CBC had a weak analgetic action in mice; THC had a moderate and lengthy effect, which was potentiated at 2 hr by concurrent CBC. 3. Both CBC (10-75 mg/kg, i.p.) and THC (20 mg/kg) reduced motility of mice, the THC equalling the highest dose of CBC. 4. Performance of a conditioned avoidance response was strongly impaired by THC, but not by CBC, nor did CBC combined with THC have influence on the effects of THC.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D002186:Cannabinoids / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D004597:Electroshock; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D002186:Cannabinoids; D002492:Central Nervous System Depressants; D013759:Dronabinol; C010695:cannabichromene