Regulation of human placental deoxyguanosine kinase by nucleotides.
The activity of deoxyguanosine kinase purified from human placenta was regulated by various nucleotides. dTTP, an activator, only increased the Vmax value of the enzyme. The feedback inhibition by dGTP, dGDP and dGMP were competitive with respect to deoxyguanosine. Both the activation by dTTP and the inhibition by dGTP were reversible.
D003848:Deoxyguanine Nucleotides / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006801:Humans; D009711:Nucleotides / Q000494:pharmacology*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor); D010920:Placenta / Q000201:enzymology*; D013942:Thymine Nucleotides / Q000494:pharmacology
D003848:Deoxyguanine Nucleotides; D009711:Nucleotides; D013942:Thymine Nucleotides; C029603:deoxyguanosine triphosphate; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); C019165:deoxyguanosine kinase; C024157:thymidine 5'-triphosphate