Studies on osteoporoses. XI. Effects of a methylxanthine derivative. A preliminary report.
Heparin (500 U/kg s.c. B.I.D.) induced significant osteoporosis in C3H/St(Ha) female mice after 3 months of treatment. Pentoxifylline (12 mg/kg i.m. B.I.D.) prevented this experimental osteoporosis. Osteoporosis was measured by in vivo neutron activation analysis and results were confirmed by atomic absorption spectroscopy. Pentoxifylline (0.1-100 microgram/ml) increased calcium uptake and cAMP production in osteoblast-like bone cells isolated from fetal Sprague-Dawley rats. Theoretical implications for osteoblast control of bone resorption are discussed.
D000818:Animals; D001862:Bone Resorption; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006493:Heparin; D051379:Mice; D008809:Mice, Inbred C3H; D009501:Neutron Activation Analysis; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D010024:Osteoporosis / Q000139:chemically induced / Q000517:prevention & control*; D010431:Pentoxifylline / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013054:Spectrophotometry, Atomic; D013268:Stimulation, Chemical; D013805:Theobromine / Q000031:analogs & derivatives*
D006493:Heparin; D000242:Cyclic AMP; D013805:Theobromine; D010431:Pentoxifylline; D002118:Calcium