A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: seroconversion in recipients.
Possible transmission of adult T cell leukemia virus (ATLV) by blood transfusion was studied retrospectively. Of 41 recipients of whole blood or blood components containing cells from donors having antibodies to antigen that is associated with ATLV (anti-ATLA), 26 (63.4%) produced anti-ATLA. However, no anti-ATLA was detected in all 14 recipients of fresh-frozen plasma prepared from anti-ATLA-positive donors. None of 252 recipients of blood with cell components from anti-ATLA-negative donors produced anti-ATLA. The development of anti-ATLA in the recipients may correspond to antibody production after establishment of primary infection with ATLV that is associated with cells in blood from anti-ATLA-positive donors who are ATLV carriers.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000912:Antibodies, Neoplasm / Q000096:biosynthesis; D000914:Antibodies, Viral / Q000096:biosynthesis; D001773:Blood Cells / Q000382:microbiology; D001782:Blood Donors; D002675:Child, Preschool; D017977:Deltaretrovirus / Q000276:immunology; D005260:Female; D006801:Humans; D007938:Leukemia / Q000517:prevention & control / Q000635:transmission*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012190:Retroviridae / Q000276:immunology; D012192:Retroviridae Infections / Q000517:prevention & control / Q000635:transmission*; D065227:Transfusion Reaction
D000912:Antibodies, Neoplasm; D000914:Antibodies, Viral