Induced underglycosylation of PLC/PRF/5 human hepatoma cells. Brief report.
The production of HBsAg and human plasma proteins by PLC/PRF/5 human hepatoma cell line was studied in the presence of glycosylation inhibitors. The data presented here suggest that HBsAg release in culture medium by these cells is not reduced by an inhibition of glycosylation and that Tunicamycin may play a role in a mobilization of the intracellular pool of antigen.
D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D002460:Cell Line; D006023:Glycoproteins / Q000096:biosynthesis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D014415:Tunicamycin / Q000494:pharmacology
D006023:Glycoproteins; D006514:Hepatitis B Surface Antigens; D014415:Tunicamycin