Alteration of phenotype of 'regressor' avian sarcoma cells following treatment with phorbol ester.
Tumor cells which are cultured from the regressor phase of avian sarcoma virus (ASV)-induced tumor growth are deficient with respect to ability to produce progeny transforming virus. In addition, such cells are relatively unreactive with anti-viral antibody and are unable to elaborate, into the medium, antigens which are stimulatory to the sensitized lymphocytes of virus-injected hosts. These deficits can be overcome by treatment of the cells with the tumor promoter, phorbol myristate acetate (PMA).
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000187:drug effects / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002642:Chick Embryo; D002645:Chickens; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D008297:Male; D010641:Phenotype; D010704:Phorbols / Q000633:toxicity*; D001357:Sarcoma, Avian / Q000382:microbiology; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D010704:Phorbols; D013755:Tetradecanoylphorbol Acetate