The influence of a high K intake on the hypertensive effect of ACTH and DOC in sheep.
The effect of 5 days administration of ACTH or DOC, was examined before and after chronic potassium (K) loading in sheep. K loading raised plasma [K], urine volume and K excretion but had no effect on mean arterial pressure (MAP). On a normal K intake DOC (5 mg/day i.v.) increased MAP and plasma sodium [Na]. Plasma [K], urinary Na (day 1) and K (day 1) excretion were decreased. On a high K intake (congruent to 800 mmol K/day), DOC lowered plasma [K] but had no effect on MAP or Na excretion. The hypertensive effects of ACTH were not affected by K intake.
D000324:Adrenocorticotropic Hormone; D000818:Animals; D003900:Desoxycorticosterone; D005260:Female; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D011188:Potassium / Q000494:pharmacology*; D012756:Sheep
D003900:Desoxycorticosterone; D000324:Adrenocorticotropic Hormone; D011188:Potassium