title: Pharmacological and biochemical evidence for the existence of two categories of dopamine receptor.
abstract: Evidence supporting the validity of the 'two dopamine receptor' hypothesis is presented. The availability of the 'first generation' of selective agonists and antagonists of the D-1 and the D-2 dopamine receptors provides pharmacological support for the hypothesis. The demonstration that stimulation of the D-2 receptor either inhibits or has no effect upon adenylate cyclase activity while stimulation of the D-1 receptor enhances cAMP formation provides biochemical support for the hypothesis. Finally, binding assays demonstrating two affinity states for the D-1 and the D-2 receptors are briefly discussed.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D000242:Cyclic AMP / Q000096:biosynthesis; D010902:Pituitary Gland / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013268:Stimulation, Chemical
chemical_list: D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D000242:Cyclic AMP