The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions.
Ca2+-dependent K+ channels responsible for the long-lasting after-hyperpolarization in rat muscle cells in culture are not those extensively studied by the patch-clamp technique. The first ones are blocked by apamin, a bee venom polypeptide, and they are unaffected by tetraethylammonium (TEA) whereas the second ones are blocked by TEA and unaffected by apamin. These two Ca2+-dependent K+ channels coexist in rat muscle cells in culture but also probably in many other cellular types.
D000818:Animals; D000831:Animals, Newborn; D001030:Apamin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D002478:Cells, Cultured; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D007473:Ion Channels; D013757:Tetraethylammonium Compounds; D001030:Apamin; D019789:Tetraethylammonium; D011188:Potassium; D002118:Calcium