Virus-induced diabetes mellitus in ICR Swiss mice is age dependent.
Adult male ICR Swiss mice develop diabetes mellitus when infected with the D variant of encephalomyocarditis virus. It was determined that the disease syndrome caused by the virus in this mouse strain is dependent upon the age of the animals. Mice younger than 7 weeks developed lethal encephalitis, whereas those past this age developed diabetes. The susceptibility of young mice to the diabetogenic effects of encephalomyocarditis virus was enhanced by testosterone.
D000375:Aging; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000209:etiology*; D004198:Disease Susceptibility; D004660:Encephalitis / Q000209:etiology; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000209:etiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D013739:Testosterone / Q000494:pharmacology
D013739:Testosterone