Evidence for a bicuculline-insensitive long-lasting inhibition in the CA3 region of the rat hippocampal slice.
Long-lasting inhibition (up to 2 s) of the commissurally-evoked response in the CA3 region of hippocampal slices was observed following a mossy fibre or commissural conditioning stimulus. Bicuculline applied iontophoretically or by superfusion (1-5 X 10(-6) M) blocked the early phase (20-40 ms) of the post-stimulus inhibition but either had no effect or potentiated the later inhibition.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology*; D046508:Culture Techniques; D004292:Dominance, Cerebral / Q000187:drug effects; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D051381:Rats; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D001640:Bicuculline