Growth factors and their action in vivo and in vitro.
The molecular nature and mechanism of action of several of the growth factors including epidermal growth factor, fibroblast growth factor and platelet-derived growth factor is reviewed. The ectopic production of growth factors may be important in the growth development of certain tumours. In addition, attention is directed to the importance of the extracellular matrix in controlling cell proliferation and differentiation.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism / Q000502:physiology; D066246:ErbB Receptors; D005109:Extracellular Matrix; D005346:Fibroblast Growth Factors / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D051379:Mice; D010455:Peptides / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism; D013002:Somatomedins / Q000502:physiology; D015291:Transforming Growth Factors
D006133:Growth Substances; D010455:Peptides; D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D013002:Somatomedins; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors; D066246:ErbB Receptors