title: Independent segregation of ev 10 and ev 11, genetic loci for spontaneous production of endogenous avian retroviruses.
abstract: F1 males produced by crossing Regional Poultry Research Laboratory line 15I4 that carries endogenous viral (ev) genes 1, 6, and 10 and a partially defined gene, ev 11, with line 15B that carries ev 1 and 7 were backcrossed to line 15B females. The DNA of 72 progeny embryos was digested by BamHI and Kpn and hybridization of resulting fragments with 32P-labeled viral RNA showed that ev 6, 10, and 11 were autosomal genes and not closely linked, and confirmed that ev 7 was sex linked. ev 10 and 11 were consistently associated with complete virus production, confirming that the newly defined ev 11 codes for a complete endogenous retrovirus.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics* / Q000382:microbiology; D003433:Crosses, Genetic; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D005260:Female; D005814:Genes, Viral; D008040:Genetic Linkage; D008297:Male; D009693:Nucleic Acid Hybridization; D010641:Phenotype; D012190:Retroviridae / Q000235:genetics* / Q000502:physiology
chemical_list: D004247:DNA; D004262:DNA Restriction Enzymes