beta-endorphin stimulates in vivo lipolysis in the rabbit.
beta-endorphin stimulates lipolysis in vitro in isolated fat cells of the rabbit. To exclude effects of collagenases and local proteases we investigated the effect of beta-endorphin on glycerol, free fatty acids and glucose plasma levels in the rabbit with and without naloxone. beta-endorphin increased free fatty acids and glycerol while glucose remained unaffected. The increase of glycerol and free fatty acids could be blocked by naloxone, suggesting the involvement of different receptors.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004723:Endorphins / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007700:Kinetics; D008066:Lipolysis / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D011817:Rabbits; D001615:beta-Endorphin
D001786:Blood Glucose; D004723:Endorphins; D005230:Fatty Acids, Nonesterified; D009270:Naloxone; D001615:beta-Endorphin