title: Prolactin-enhanced grooming behavior: interaction with ACTH.
abstract: The interaction between prolactin (PRL) and ACTH in enhancing grooming behavior after intracerebroventricular (i.c.v.) administration was investigated in intact and endogenously hyperprolactinaemic rats. In intact rats, 4 h after the i.c.v. injection of rat PRL or ACTH, a subsequent administration of ACTH or rat PRL did induce similar excessive grooming as observed after the first injections. In hyperprolactinaemic rats, which displayed excessive grooming 12 days after homografting adenopituitaries under the kidney capsule, i.c.v. injection of rat PRL failed to enhance further the grooming activity while this behavior was substantially enhanced by i.c.v. injection of ACTH1-24. Twenty-six days after surgery, when the grooming activity of hyperprolactinaemic rats was at the same level as control animals, the i.c.v. injection of rat PRL was effective in inducing excessive grooming in control but not in hyperprolactinaemic animals. In contrast, at this time the i.c.v. injection of ACTH1-24 induced again excessive grooming in both hyperprolactinaemic and control rats. Accordingly, there was no cross-tolerance between PRL and ACTH in inducing excessive grooming, but hyperprolactinaemic rats became hyposensitive to exogenous PRL. It is suggested that although PRL and ACTH may affect common neurotransmitter systems in the brain, the two hormones probably act on independent neural mechanisms in inducing excessive grooming in the rat.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004361:Drug Tolerance; D006120:Grooming / Q000187:drug effects*; D008297:Male; D010902:Pituitary Gland / Q000637:transplantation; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000324:Adrenocorticotropic Hormone; D011388:Prolactin