Effect of pentagastrin on adrenocorticotropin hormone and thyroid-stimulating hormone release in normal subjects.
The possible role of gastrin on TSH, ACTH and cortisol secretion was evaluated by intravenous administration of pentagastrin, the carboxyl-terminal tetrapeptide of gastrin (0.5 microgram/kg b.w.) into 12 healthy subjects. Pentagastrin produced a significant rise in plasma ACTH and cortisol levels but did not alter TSH basal release. These preliminary results suggest that gastrin can influence basal activity of ACTH-cortisol axis. However, further investigation is required to determine its physiological role and mechanisms of action.
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D013972:Thyrotropin / Q000378:metabolism*; D013997:Time Factors
D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D010418:Pentagastrin; D006854:Hydrocortisone