Potentiation of antitumor activity of 5-fluoro-2'-deoxyuridine by guanosine-5'-monophosphate.
The antitumor activity of 5-fluoro-2'-deoxyuridine (FUdR) against P388 leukemia was markedly enhanced by addition of guanosine-5'-monophosphate (GMP). With daily i.p. treatment for 5 d, the combination of FUdR at 100 mg/kg/d and GMP at 300 mg/kg/d showed the highest antitumor effect (more than 290% ILS), while maximum ILS of FUdR alone (100 mg/kg/d) was 94%.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology* / Q000627:therapeutic use; D006152:Cyclic GMP / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D005467:Floxuridine / Q000008:administration & dosage / Q000494:pharmacology*; D005472:Fluorouracil / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D005467:Floxuridine; D006152:Cyclic GMP; D005472:Fluorouracil