Immunological identification of peripheral-blood lymphocytes from patients with lymphoproliferative disorders in Nigeria. I. Acute lymphocytic leukaemia (ALL).
The peripheral-blood lymphocytes of eight consecutively diagnosed cases of acute lymphocytic leukaemia (ALL) in Nigerians seen over a period of 2 years were classified as T, B and Null cells, using mainly sheep-rosetting (for T cells) and EAC-rosetting (for B cells) techniques. The patients' lymphocytes response to stimulation with phytohaemagglutinin (PHA) and basic haematological parameters were also determined. There were three male cases (37.5%), aged 10, 14 and 21 years who had T-cell ALL and one boy (12.5%) aged 10 years with B-cell ALL. The remaining four patients (50%) were two girls aged 6 and 6 1/2 years and two males aged 10 and 21 years who had lymphocytic leukaemia of the Null-cell class. These results from a tropical environment agree with previous findings among Caucasians with respect to the age and sex incidence and predominance of ALL with Null cells.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008215:Lymphocytes, Null / Q000276:immunology*; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D012397:Rosette Formation; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology*
D010835:Phytohemagglutinins