Mechanism of tetanolysin-induced membrane damage: studies with black lipid membranes.
Tetanolysin produced similar rates of leakage of K+ and hemoglobin from erythrocytes. When studied by using cholesterol-containing black lipid membranes, this hemolysin induced conductance steps with a broad frequency distribution. These findings are inconsistent with the formation of structural channels and suggest that tetanolysin acts by causing lipid perturbations.
D001427:Bacterial Toxins / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003017:Clostridium tetani; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects; D008567:Membranes, Artificial; D011188:Potassium / Q000097:blood; D013744:Tetanus Toxin
D001427:Bacterial Toxins; D006454:Hemoglobins; D007473:Ion Channels; D008567:Membranes, Artificial; D013744:Tetanus Toxin; C026167:tetanolysin; D011188:Potassium