Rat liver microsomal transformation of ethene to oxirane in vitro.
Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.
D000478:Alkylation; D000818:Animals; D001711:Biotransformation; D003035:Cobalt / Q000494:pharmacology; D004050:Ditiocarb / Q000494:pharmacology; D005027:Ethylene Oxide / Q000096:biosynthesis*; D005030:Ethylenes / Q000378:metabolism*; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005030:Ethylenes; D003035:Cobalt; D009249:NADP; C036216:ethylene; D004050:Ditiocarb; C018021:cobaltous chloride; D005027:Ethylene Oxide; D010634:Phenobarbital; D008797:Metyrapone