Toxic effect of the peroxidase-hydrogen peroxide-halide antimicrobial system on Mycobacterium leprae.
Mycobacterium leprae are killed by myeloperoxidase (or eosinophil peroxidase), H2O2, and a halide, thus suggesting a mechanism for their destruction by peroxidase-containing phagocytes.
D000818:Animals; D000900:Anti-Bacterial Agents; D001965:Bromides / Q000633:toxicity*; D002712:Chlorides / Q000633:toxicity*; D004285:Dogs; D047209:Eosinophil Peroxidase; D004804:Eosinophils / Q000201:enzymology; D006736:Horses; D006861:Hydrogen Peroxide / Q000633:toxicity*; D007454:Iodides / Q000633:toxicity*; D009166:Mycobacterium leprae / Q000187:drug effects*; D009195:Peroxidase / Q000633:toxicity*; D010544:Peroxidases / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D001965:Bromides; D002712:Chlorides; D007454:Iodides; D006861:Hydrogen Peroxide; D047209:Eosinophil Peroxidase; D010544:Peroxidases; D009195:Peroxidase