title: Effects of androgens on the activity of steroid-metabolizing enzymes in the murine submaxillary gland.
abstract: Effects of androgens on the activity of androgen-metabolizing enzymes have been investigated in the murine submaxillary gland. 5 alpha-reductase activity is androgen-dependent, and 17 beta-hydroxysteroid dehydrogenase activity is androgen-resistant. The level and androgen-responsiveness of 5 alpha-reductase in the murine submaxillary gland are not imprinted during the neonatal period by testicular androgens. Circulating androgen may have a cumulative effect on androgen response of 5 alpha-reductase.
mesh_terms: D015067:17-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D002369:Castration; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010088:Oxidoreductases / Q000378:metabolism*; D012741:Sexual Maturation; D013363:Submandibular Gland / Q000201:enzymology*; D013739:Testosterone / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D000735:Androstenedione; D010088:Oxidoreductases; D015067:17-Hydroxysteroid Dehydrogenases; C032690:3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase