[Antiaggregating action on thrombocytes of a new anti-arrhythmia agent of the phenothiazine series--diethylamine ethmozine analog].
A new antiarrhythmic drug of phenothiazine series diethylamine ethmozine analogue inhibited the rabbit's platelet aggregation induced by ADP, serotonin and thrombin. The degree of inhibition depended on the drug concentration and time of its incubation with platelets as well as on the inducer concentration. The transition from ADP-induced (5 microM) aggregation to reversible one was observed under the influence of relatively small doses of the drug. A gradual restoration of the platelet aggregating capacity occurred after washing platelets off the drug. The nonadditive character of the studied agent effects and that of theophylline on the platelets makes it possible to suppose that cAMP participates in the mechanism of the drug action on the platelets. The described antiaggregating effect of the drug on the platelets should be taken into account when it is used as an antiarrhythmic agent.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D066298:In Vitro Techniques; D016293:Moricizine / Q000031:analogs & derivatives*; D010640:Phenothiazines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine; D000244:Adenosine Diphosphate; D000242:Cyclic AMP
Antiagregatsionnoe deĭstvie na trombotsity novogo antiaritmicheskogo preparata fenotiazinovogo riada--diétilaminovogo analoga étmozina.