Evidence for an adenosine receptor in human tissues.
Our observations suggest that [3H] chloroadenosine, an adenosine receptor agonist, identifies binding sites in human placenta with characteristics of the high affinity, adenosine receptor. The binding is time dependent, reversible and saturable. The potency series of adenosine receptor methylxanthine antagonists in displacing [3H] chloroadenosine is appropriate.
D000241:Adenosine / Q000378:metabolism*; D000262:Adenylyl Cyclases / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011983:Receptors, Purinergic; D013154:Spleen / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*; D014018:Tissue Distribution
D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic; D000262:Adenylyl Cyclases; D000241:Adenosine