Pulmonary vascular resistance changes in experimental hemorrhagic shock.
Hemorrhagic shock was experimentally induced in 40 mongrel dogs, and the resulting pulmonary vascular resistances studied. A mechanical test with closure of the left branch of the pulmonary artery and two pharmacological tests with isoproterenol (isuprel) and cyclic adenosine-monophosphate (cAMP) were performed. The results suggest that there is a block in the beta-control during prolonged shock, and that beta-control is restored by cAMP.
D000818:Animals; D000242:Cyclic AMP; D004285:Dogs; D007545:Isoproterenol; D011651:Pulmonary Artery / Q000503:physiopathology*; D011667:Pulmonary Veins / Q000503:physiopathology*; D011669:Pulmonary Wedge Pressure; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013314:Stress, Mechanical; D014655:Vascular Resistance
D000242:Cyclic AMP; D007545:Isoproterenol