Influence of fly ash and charcoal on the inducer activity of benzo[a]pyrene and smoke condensate in the gut mucosa of the rat.
Fly ash from either peat- or coal-fired power plants is unable to block the inducer activity of benzo[a]pyrene in the gastrointestinal tract. Activated charcoal retains adsorbed polycyclic aromatic hydrocarbons during passage through the gut so that no induction of polysubstrate monooxygenase occurs in the mucosa.
D000818:Animals; D001564:Benzo(a)pyrene; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis; D001580:Benzopyrenes / Q000494:pharmacology*; D002244:Carbon / Q000494:pharmacology*; D002273:Carcinogens / Q000494:pharmacology*; D002606:Charcoal / Q000494:pharmacology*; D060729:Coal Ash; D019363:Cytochrome P-450 CYP1A1; D004790:Enzyme Induction; D007413:Intestinal Mucosa / Q000201:enzymology*; D008297:Male; D010078:Oxazines / Q000378:metabolism; D010088:Oxidoreductases / Q000096:biosynthesis; D052638:Particulate Matter; D010947:Plants, Toxic; D051381:Rats; D011916:Rats, Inbred F344; D012906:Smoke; D014026:Nicotiana
D001580:Benzopyrenes; D002273:Carcinogens; D060729:Coal Ash; D010078:Oxazines; D052638:Particulate Matter; D012906:Smoke; D002606:Charcoal; D001564:Benzo(a)pyrene; C007649:ethoxyresorufin; D002244:Carbon; D010088:Oxidoreductases; D001579:Benzopyrene Hydroxylase; D019363:Cytochrome P-450 CYP1A1