Effect of ceftizoxime, a new cephalosporin antibiotic, on binding of bilirubin to human serum albumin.
An investigation and comparison of the competitive effect of ceftizoxime, a new cephalosporin, and other beta-lactam antibiotics on in vitro binding of bilirubin to human serum albumin showed that at a normal range of serum albumin (3.48 g/dl) and bilirubin (0.94 mg/dl) in healthy infants, free bilirubin did not increase in the presence of any of the test antibiotics at concentrations up to 640 micrograms/ml. When the albumin concentration was decreased to one-fifth of the normal human range, only ceftizoxime caused no bilirubin displacement.
D000900:Anti-Bacterial Agents / Q000097:blood; D001663:Bilirubin / Q000097:blood*; D001667:Binding, Competitive; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D015296:Ceftizoxime; D006801:Humans; D010544:Peroxidases / Q000032:analysis; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism
D000900:Anti-Bacterial Agents; D012709:Serum Albumin; D015296:Ceftizoxime; D010544:Peroxidases; D002439:Cefotaxime; D001663:Bilirubin