In vitro lipolysis of proopiocortin peptides.
Since there is accumulating evidence for metabolic functions of proopiocortin peptides, we investigated 42 partial sequences for their lipolytic activity in isolated rabbit fat cells. 4 lipolytic active centers can be suggested: in the N-terminal part of proopiocortin (not gamma- and delta-MSH), in the N-terminal region of ACTH (ACTH 4-1o), in the beta-MSH sequence of beta-lipotropin and in the C-terminal region of beta-endorphin.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D004723:Endorphins / Q000494:pharmacology*; D005260:Female; D008066:Lipolysis / Q000187:drug effects*; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D010908:Pituitary Hormones, Anterior / Q000494:pharmacology*; D011333:Pro-Opiomelanocortin; D011498:Protein Precursors / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000494:pharmacology*
D004723:Endorphins; D010908:Pituitary Hormones, Anterior; D011498:Protein Precursors; D001615:beta-Endorphin; D011333:Pro-Opiomelanocortin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008083:beta-Lipotropin