[Terbutaline-induced metabolic responses after propranolol and metoprolol].
Subcutaneously administered terbutaline (7 micrograms/kg Bricanyl) induced typical changes in carbohydrate and fat metabolism and cardiovascular effects in ten healthy volunteers. A significant inhibition of changes in systolic and diastolic blood pressure, heart rate and plasma glycerol, FFA, lactate and potassium levels was seen after pretreatment with 0.1 mg/kg propranolol (Dociton) or 0.2 mg/kg metoprolol (Beloc). Intravenous metoprolol showed weaker beta-blocking activity than propranolol, but proved to be more effective in its action on systolic blood pressure.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004336:Drug Antagonism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007773:Lactates / Q000378:metabolism; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013726:Terbutaline / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D007773:Lactates; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D008790:Metoprolol; D005947:Glucose; D013726:Terbutaline; D005990:Glycerol; D011188:Potassium
Terbutalin-induzierte Stoffwechselreaktionen unter Propranolol und Metoprolol.