title: Kinetics of 201Tl uptake in adenomas and well-differentiated carcinomas of the thyroid. A double isotope investigation with 99Tcm and 201Tl.
abstract: A visually increased uptake of 201Tl chloride corresponding to a 'cold' (131I or 99Tcm ) thyroid nodule is mostly seen in well-differentiated carcinomas but also often in follicular adenomas. Since a visually increased uptake of 201Tl can be due to an increased initial uptake and/or a delayed elimination, an extended dynamic investigation was performed in patients with well-differentiated carcinomas or with follicular adenomas. Data were collected in a dynamic simultaneous double isotope ( 99Tcm + 201Tl) study up to 50 min after intravenous administration. Adenomas could be significantly separated from carcinomas by the elimination (p = 0.0001), but not by the initial uptake.
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging* / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007700:Kinetics; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013223:Statistics as Topic; D013667:Technetium / Q000378:metabolism; D013793:Thallium / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D011868:Radioisotopes; C027549:thallium chloride; D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m; D013793:Thallium