Effect of cholecystokinin on self-stimulation behavior in rats.
Experiments were performed to examine the effects of intracerebroventricularly administered cholecystokinin octapeptide sulfate ester (CCK-8-SE) and unsulfated cholecystokinin octapeptide (CCK-8-NS) on electrical self-stimulation behavior elicited from the medial forebrain bundle. CCK-8-SE and CCK-8-NS in 80 pmol doses reduced the response rate of self-stimulation behavior 22-30 min following injection, while 400 pmol doses of these peptides attenuated self-stimulation behavior between 13 and 36 min. It is suggested that CCK-8-SE and CCK-8-NS interact with central rather than peripheral nervous mechanisms.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004558:Electric Stimulation; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects*; D012844:Sincalide / Q000494:pharmacology
D002766:Cholecystokinin; D012844:Sincalide