title: Electrophysiological effects of angiotensin II on cultured mouse spinal cord neurons.
abstract: The effects of angiotensin II (AII) on the membrane properties of cultured spinal neurons were investigated using electrophysiological methods. In 26% of neurons tested AII induced changes in membrane potential and input resistance which varied according to the concentration of applied peptide. At low concentrations (10(-6) M), AII increased input resistance by an ionic mechanism which appears to involve a reduction in Cl- conductance. At higher concentration (10(-4) M), AII evoked depolarization associated with a decrease in input resistance. This response appears to depend on an increase in Na+ conductance. Our observations indicate that AII can have multiple effects on neuronal membrane properties dependent on the concentration of applied peptide.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002712:Chlorides / Q000378:metabolism; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D007473:Ion Channels / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D009474:Neurons / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D002712:Chlorides; D007473:Ion Channels; D000804:Angiotensin II