Invasive squamous cell carcinoma of the uterine cervix. VI. Prediction value of non-keratinizing, parakeratotic and orthokeratotic cell forms and clinical staging.
In 393 patients with invasive squamous cell carcinoma of the uterine cervix stages I to IV the predictive value of the histopathologic classification of Reagan & Wentz (differentiation into cell type) was analysed in relation to 10-year lethality rate. Patients with large cell horn-pearl forming and orthokeratinizing tumours had the poorest, and those with large cell non-keratinizing the best prognosis. Large cell parakeratotic tumours did not differ significantly in prognosis compared with the non-keratinizing cell form. When clinical staging was included the prediction value of the histopathologic classification disappeared except in stage II. From a clinical point of view this additional prognostic information will have little practical consequences.
D000328:Adult; D000368:Aged; D018288:Carcinoma, Small Cell / Q000473:pathology / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007642:Keratosis / Q000473:pathology; D008875:Middle Aged; D010241:Parakeratosis / Q000473:pathology; D011379:Prognosis; D011882:Radiotherapy, High-Energy; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*