Control of physiological response in the rat by dietary nutrient concentration.
In three separate experiments, growing, male Sprague-Dawley rats were fed diets which contained: 1) graded levels of fiber 0-70%, 2) graded levels of pyridoxine 1-10 mg/kg diet, and 3) graded levels of casein 0-30%. The following physiological responses were measured in each respective experiment: 1) food intake, weight gain, serum triglycerides, 2) food intake, weight gain, SGPT levels, and 3) weight specific food intake, weight gain, relative testes weight. Diets were fed as a single source, and in each case, physiological response could be predicted as a function of dietary nutrient concentration. When self-selection is prevented, rats establish new steady-state response profiles, which are sigmoidal in shape and dependent on the interaction of the rats' genetic potential with the environmental configuration.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002364:Caseins / Q000008:administration & dosage*; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008954:Models, Biological; D009929:Organ Size / Q000187:drug effects; D011736:Pyridoxine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000033:anatomy & histology; D013816:Thermodynamics; D014280:Triglycerides / Q000097:blood
D002364:Caseins; D004043:Dietary Fiber; D014280:Triglycerides; D000410:Alanine Transaminase; D011736:Pyridoxine