title: Complete amino acid sequence of the basic nucleic acid binding protein of feline leukemia virus.
abstract: The complete amino acid sequence of the nucleic acid binding protein p10 of the Rickard strain of feline leukemia virus (FeLV) has been determined. Fragments obtained by enzymatic digestion were purified by reverse-phase liquid chromatography and subjected to semiautomated Edman degradation. FeLV p10 is a basic polypeptide composed of 57 amino acids with Mr = 6604. The structure of p10 is compared to the structures of other retroviral nucleic acid binding proteins, and an analysis of a highly conserved region, the putative binding domain, is presented.
mesh_terms: D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D002918:Chymotrypsin; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000302:isolation & purification; D010450:Endopeptidases; D005256:Leukemia Virus, Feline / Q000235:genetics*; D010446:Peptide Fragments / Q000032:analysis; D012190:Retroviridae / Q000235:genetics; D015682:Retroviridae Proteins, Oncogenic; D012697:Serine Endopeptidases; D013045:Species Specificity; D014764:Viral Proteins / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D004268:DNA-Binding Proteins; D010446:Peptide Fragments; D015682:Retroviridae Proteins, Oncogenic; D014764:Viral Proteins; C040785:p10 protein, feline leukemia virus; D010450:Endopeptidases; D012697:Serine Endopeptidases; D002918:Chymotrypsin; C028344:glutamyl endopeptidase