[Lithium and acute myeloid leukemia].
The authors report a case of acute myeloid leukemia in a thirty-four-year-old man who had been under lithium carbonate for the last six months for manic-depressive psychosis. One year after treatment with cytosine-arabinoside, 6-thioguanine and daunorubicin, the patient is still in complete remission. In the medical literature we found seven additional reports of acute or chronic myeloid leukemia after lithium therapy. Lithium was found to enhance granulopoiesis. Our findings suggest that lithium may initiate or promote leukemia.
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001714:Bipolar Disorder / Q000188:drug therapy; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000188:drug therapy; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male
D000970:Antineoplastic Agents; D003115:Colony-Stimulating Factors; D016651:Lithium Carbonate; D008094:Lithium
Lithium et leucémie aiguë myéloïde.