Regulation of the cellular actin levels in response to changes in the cell density in ataxia telangiectasia lymphoblastoid cells.
The level of actin was found to decrease markedly when ataxia telangiectasia lymphoblastoid cells were stepped from low to high density culture conditions. Additionally, as the actin levels decreased the levels of a protein species of 37K daltons increased by orders of magnitude. Partial proteolytic digestion of the 37K protein and actin revealed that the primary structures of these proteins were not related. This phenomena was observed in three out of four ataxia telangiectasia lymphoblastoid cell lines but not in lymphoblastoid cells derived from normal individuals.
D000199:Actins / Q000096:biosynthesis / Q000378:metabolism*; D001260:Ataxia Telangiectasia / Q000378:metabolism*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004591:Electrophoresis, Polyacrylamide Gel; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008970:Molecular Weight
D000199:Actins