The effect of naloxone in different gastroduodenal ulcer models.
On the basis of our investigations it seems that: The opiate antagonist naloxone in a dose of 5.0 mg/kg has a significant protective effect in stress-ulcer model in the rat; No such effect was seen in drug (indomethacin) or cysteamine induced (duodenal) ulcer models; The interaction of naloxone with indomethacin seems to show a sex-difference.
D000818:Animals; D003543:Cysteamine; D004195:Disease Models, Animal; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin; D008297:Male; D009270:Naloxone / Q000494:pharmacology* / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects; D012737:Sex Factors; D013312:Stress, Physiological / Q000150:complications
D011957:Receptors, Opioid; D009270:Naloxone; D003543:Cysteamine; D007213:Indomethacin