Influence of phenobarbital on glycogen metabolism of rat liver pretreated with N-nitrosomorpholine.
Sprague-Dawley rats were treated with N-nitrosomorpholine (NNM) alone (7 weeks, 120 mg/l in drinking water), with NNM followed by phenobarbital (PB) (750 mg/l for 6 weeks) or PB alone. The livers from these animals were investigated for glycogen content and activities of glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, glycogen phosphorylase and glycogen synthetase. The following parameters proved to be significantly altered in the livers of rats treated with either NNM or PB or both compared with untreated controls: glycogen content was increased and the activities of glucose-6-phosphatase and glycogen synthetase were decreased. Although these data show some similarities in changes of glycogen metabolism of livers treated with NNM or PB, earlier histochemical investigations revealed important differences in the distribution of these alterations within the liver parenchyma.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004347:Drug Interactions; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D009602:Nitrosamines / Q000633:toxicity*; D010634:Phenobarbital / Q000494:pharmacology*; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D008112:Liver Glycogen; D009602:Nitrosamines; C002741:N-nitrosomorpholine; D005954:Glucosephosphate Dehydrogenase; D006005:Phosphorylases; D006006:Glycogen Synthase; D005952:Glucose-6-Phosphatase; D010634:Phenobarbital