Protection of microcirculation in rat brain against late radiation injury by gammaphos.
The ability of a radioprotector-gammaphos to modify the development of late vascular changes in the rat brain after local irradiation with 40 and 60 Gy was investigated by means of an angiographic method. The relative number of animals with gross vascular abnormalities, the size of foci with vascular lesions, and the changes in size and number of vessels were less in the drug-treated groups. Thus, it may be possible to increase the tolerance of host tissues to curative radiation therapy by chemical radioprotectors such as gammaphos.
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000098:blood supply*; D004307:Dose-Response Relationship, Radiation; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009946:Organothiophosphorus Compounds; D004999:Amifostine