The persistence of benzo[a]pyrene diol-epoxide deoxyguanosine adduct in mouse skin and its disappearance in rat skin.
Male Swiss mice and Wistar rats, susceptible and resistant, respectively, to the carcinogenic effects of benzo[a]pyrene, were treated topically with 250 nmol/mouse and 1000 nmol/rat of tritium labelled benzo[a]pyrene (BaP). The initial formation of BaP diol-epoxide deoxyguanosine adduct was approximately similar in the skin epidermis of the two species. After 3 weeks, the persistence of some 6.5% of initial BaP diol-epoxide deoxyguanosine was observed in mouse skin DNA, while this adduct was completely removed from DNA of rat skin. The total excision of BaP diol-epoxide deoxy-guanosine adduct in rat epidermis may contribute in part for the relative resistance of rat skin to the carcinogenic actions of BaP.
D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D003849:Deoxyguanosine / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism*; D013045:Species Specificity; D014316:Tritium
D001580:Benzopyrenes; D014316:Tritium; D001564:Benzo(a)pyrene; D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; D004247:DNA; D003849:Deoxyguanosine