Integrated management of bacteraemic shock in neutropenia.
The neutropenic mouse model of endotoxin-associated, enterobacterial sepsis was used to evaluate the individual and cumulative effects of anti-infective, anti-endotoxic, anti-inflammatory and anti-endorphic strategies. Survival was maximized following the administration of ticarcillin, polymyxin, methylprednisolone and naloxone.
D000380:Agranulocytosis / Q000150:complications*; D000818:Animals; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D008775:Methylprednisolone / Q000008:administration & dosage; D051379:Mice; D008954:Models, Biological; D009270:Naloxone / Q000008:administration & dosage; D009503:Neutropenia / Q000150:complications*; D011113:Polymyxins / Q000008:administration & dosage; D011379:Prognosis; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology; D013982:Ticarcillin / Q000008:administration & dosage
D011113:Polymyxins; D009270:Naloxone; D013982:Ticarcillin; D008775:Methylprednisolone