Erythrocyte ouabain binding in dementia.
Age-matched patients attending a geriatric psychiatry day hospital, one group with Alzheimer's dementia and another with functional illness, were studied and compared with similar inpatient groups. Erythrocyte ouabain binding was assayed and Clifton ratings completed. In day hospital patients ouabain binding was significantly lower in the demented group (p less than 0.008) than in the functional group. There was a positive correlation between Clifton ratings and ouabain in the whole group (p less than 0.05). No significant differences were found in inpatient groups. Possible reasons for findings are discussed.
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood*; D001665:Binding Sites; D003704:Dementia / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D001523:Mental Disorders / Q000378:metabolism; D010042:Ouabain / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D010042:Ouabain; D012964:Sodium; D011188:Potassium