Prostaglandin E1 and prostaglandin I2 modulation of superoxide production by human neutrophils.
15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 rapidly and reversibly inhibit formyl-methionyl-leucyl-phenylalanine induced superoxide production by human neutrophils. In contrast, 15(S)-15-methyl-prostaglandin E1 and prostaglandin I2 did not alter the rate or the total amount of superoxide production by human neutrophils stimulated with either phorbol myristate acetate or arachidonic acid. These data suggest that the production of superoxide anion by human neutrophils may be mediated by at least two mechanisms, one regulated by prostaglandins and intracellular cyclic adenosine monophosphate levels and a second independent of prostaglandin modulation.
D000527:Alprostadil / Q000031:analogs & derivatives*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009239:N-Formylmethionine / Q000031:analogs & derivatives / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D009842:Oligopeptides / Q000494:pharmacology; D010100:Oxygen / Q000097:blood*; D011453:Prostaglandins / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D013481:Superoxides / Q000097:blood*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D001095:Arachidonic Acids; D009842:Oligopeptides; D011453:Prostaglandins; D011459:Prostaglandins E, Synthetic; D013481:Superoxides; D016718:Arachidonic Acid; C025170:15(S)-15-methylprostaglandin E1; D009239:N-Formylmethionine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D011464:Epoprostenol; D000527:Alprostadil; D013755:Tetradecanoylphorbol Acetate; D010100:Oxygen