Differential modification by opioid agents of acutely enhanced noradrenaline release in discrete brain regions.
Although immobilization stress-induced increases in MHPG-SO4 level in the hypothalamus, amygdala and thalamus were enhanced by naloxone and attenuated by morphine, both agents failed to exert significant effects upon regional MHPG-SO4 levels in methamphetamine-treated rats. The results indicate that there is a differential modification by opioid agents of acutely enhanced noradrenaline release induced by physiological and by pharmacological manipulations.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D006018:Glycols / Q000032:analysis*; D007103:Immobilization; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000032:analysis*; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects; D013312:Stress, Physiological / Q000378:metabolism*
D006018:Glycols; D011957:Receptors, Opioid; C030284:3-methoxy-4-hydroxyphenylglycol sulfate; D009270:Naloxone; D008694:Methamphetamine; D008734:Methoxyhydroxyphenylglycol; D009020:Morphine; D009638:Norepinephrine