Effect of glutamic acid diethylester on (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and kainic acid-induced changes of body temperature in rats.
A low dose (1 microgram) of intracerebroventricularly injected (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) produced a hyperthermic response in rats, while a high dose of AMPA (2.5 micrograms), similarly to kainic acid (0.1 microgram) produced a biphasic effect: short-lasting hypothermia followed by hyperthermia. These effects on body temperature were not affected by pretreatment with 200 mg/kg ip of glutamic acid diethylester (GDEE), which by itself, produced a significant hypothermia. The results indicate that the effects of kainic acid and AMPA on body temperature are not mediated by GDEE-sensitive glutamate receptors.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D005971:Glutamates / Q000494:pharmacology*; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D005971:Glutamates; D010080:Oxazoles; D011759:Pyrrolidines; C011829:glutamic acid diethyl ester; D007051:Ibotenic Acid; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007608:Kainic Acid