Colchicine alters the nerve birefringence response.
The internal perfusion of squid axons with colchicine reversibly and selectively reduces the transient sodium current and the birefringence response to a brief depolarizing voltage pulse.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000502:physiology; D001718:Birefringence; D003078:Colchicine / Q000494:pharmacology*; D049832:Decapodiformes; D007473:Ion Channels / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D008870:Microtubules / Q000187:drug effects; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D012964:Sodium; D003078:Colchicine