title: The effect of infectious bursal disease virus on the immune system of turkeys.
abstract: In 1979 it was reported that an infectious bursal disease virus (IBDV) isolated from a case of respiratory disease of turkeys differed antigenically from the chicken isolates of this virus. We injected turkey poults with the turkey-originating TY89 and chicken-originating BD/6 isolates of IBDV and studied their effects on antibody production to the virus, serum immunoglobulin G (IgG), antibody response to sheep erythrocytes, in vitro response of peripheral blood lymphocytes to mitogens, and microscopic structure of the bursa of Fabricius. The chicken isolate BD/6 caused a significant decrease in the response to sheep erythrocytes, lower serum IgG, transient decrease in the response of lymphocytes to PHA, and mild microscopic lesions in the bursa of Fabricius. The turkey isolate TY89, however, caused no obvious damage to the immune system of the infected poults. We suggest that a partial and transient functional disorder of the immune system of poults can occur after infection with IBDV originating from chickens, even if the poults exhibited no clinical signs.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D004912:Erythrocytes / Q000276:immunology; D006388:Hemagglutinins / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007243:Infectious bursal disease virus / Q000276:immunology*; D008213:Lymphocyte Activation; D011201:Poultry Diseases / Q000276:immunology*; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology / Q000662:veterinary*; D012756:Sheep / Q000276:immunology; D014422:Turkeys / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D006388:Hemagglutinins; D007074:Immunoglobulin G