Laboratory and clinical studies on the mechanism of action of timolol.
Timolol is now widely used in the treatment of glaucoma but its mechanism of action is unclear. The drug decreases aqueous humor formation by the ciliary processes and is a potent beta-adrenergic antagonist. However, the physiological basis for such a drug to decrease intraocular pressure has not been clearly demonstrated.
D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects; D002415:Cats; D002924:Ciliary Body / Q000187:drug effects; D000242:Cyclic AMP / Q000096:biosynthesis; D006801:Humans; D011817:Rabbits; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013999:Timolol / Q000378:metabolism / Q000494:pharmacology*
D011943:Receptors, Adrenergic, beta; D013999:Timolol; D000242:Cyclic AMP