title: [The bioavailability of ketoprofen (Profenid) administered orally in combination with a gastric protector (aluminum phosphate, Phosphalugel)].
abstract: Bioavailability of ketoprofen associated with aluminum phosphate was studied. Subjects were studied after an initial dose given without gastric protection, after ingestion of a single dose given with aluminum phosphate and, lastly, after four days of continuous treatment with this product. Results of plasma peak level and its time of occurrence, area under the curve, half-life and elimination constant establish that bioavailability of ketoprofen is not changed by association with aluminum phosphate. It is therefore unnecessary to modify dosages in such combination treatment. Lastly, there is no change in ketoprofen absorption liable to alter its efficacy.
mesh_terms: D000284:Administration, Oral; D017607:Aluminum Compounds; D001682:Biological Availability; D004359:Drug Therapy, Combination; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D010666:Phenylpropionates / Q000378:metabolism*; D010710:Phosphates / Q000008:administration & dosage
chemical_list: D017607:Aluminum Compounds; D010666:Phenylpropionates; D010710:Phosphates; D007660:Ketoprofen; C012714:aluminum phosphate
vernacular_title: Etude de la biodisponibilité du kétoprofène (Profénid) administré par voie orale en association avec un protecteur gastrique (phosphate d'alumine, Phosphalugel).