Antiviral effects of bacteria-derived human leukocyte interferons against encephalomyocarditis virus infection of squirrel monkeys. Brief report.
Two human leukocyte interferon sub-types (IFN-alpha A and -alpha D) produced in E. coli and a hybrid interferon (IFN-alpha AD[Bgl]) consisting of the N-terminal 61 residues of IFN-alpha A and the C-terminal 104 residues of IFN-alpha D were compared for antiviral activity against EMC virus infection of squirrel monkeys. Marked reduction in viremia and a decrease in the incidence of deaths occurred with highly purified preparations of the recombinant-DNA derived interferons. Dose response studies showed that IFN-alpha D and -alpha AD (Bgl) were more effective than IFN-alpha A.
D000818:Animals; D004274:DNA, Recombinant; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000628:therapy*; D004926:Escherichia coli; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D012453:Saimiri; D013997:Time Factors; D014766:Viremia / Q000628:therapy
D004274:DNA, Recombinant; D007370:Interferon Type I