The chromosomal 3',5"-aminoglycoside phosphotransferase in Streptococcus pneumoniae is closely related to its plasmid-coded homologs in Streptococcus faecalis and Staphylococcus aureus.
The apparently chromosomally encoded 3',5"-aminoglycoside phosphotransferase (type III), from the high-level aminoglycoside-resistant Streptococcus pneumoniae BM4200, was compared with homologous enzymes coded for by the plasmids pJH1 and pSH2, originally isolated from Streptococcus faecalis and Staphylococcus aureus, respectively, and also found in a wild strain of S. aureus, BM4600. The enzymes appeared to be indistinguishable, and we conclude that the gene encoding 3',5"-aminoglycoside phosphotransferase (type III) can cross generic barriers within gram-positive cocci.
D013293:Enterococcus faecalis / Q000201:enzymology* / Q000235:genetics; D005798:Genes, Bacterial; D007526:Isoelectric Point; D019868:Kanamycin Kinase; D008970:Molecular Weight; D010770:Phosphotransferases / Q000235:genetics* / Q000378:metabolism; D010957:Plasmids; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000201:enzymology* / Q000235:genetics; D013379:Substrate Specificity
D010770:Phosphotransferases; D019868:Kanamycin Kinase