title: Gestational trophoblastic disease: the significance of vaginal metastases.
abstract: Six patients with gestational trophoblastic disease whose presenting symptom was hemorrhage from vaginal metastases are discussed. The clinical features, management, and response to treatment are outlined and it is suggested that the presence of vaginal metastases should be regarded as a poor prognostic factor and an indication for multiple cytotoxic agent chemotherapy.
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D044383:Black People; D002822:Choriocarcinoma / Q000556:secondary; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000188:drug therapy; D007231:Infant, Newborn; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011379:Prognosis; D011644:Puerperal Disorders / Q000188:drug therapy; D013997:Time Factors; D014328:Trophoblastic Neoplasms / Q000188:drug therapy* / Q000556:secondary; D014594:Uterine Neoplasms / Q000188:drug therapy*; D014625:Vaginal Neoplasms / Q000556:secondary*
chemical_list: D000970:Antineoplastic Agents