Changes in cGMP levels on meiosis reinitiation of starfish oocytes.
An intracellular level of cGMP (but not cAMP) transiently decreased the reinitiation of oocyte maturation in the starfish, Asterias amurensis. Exogenously applied cGMP inhibited hormone-induced maturation. Methylxanthines inhibited oocyte maturation by suppressing the decrease in cGMP levels. These results suggest that a decrease in cGMP levels is a prerequisite for meiosis reinitiation of starfish oocytes.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D008540:Meiosis / Q000187:drug effects; D009865:Oocytes / Q000166:cytology / Q000378:metabolism*; D010063:Ovum / Q000378:metabolism*; D013215:Starfish; D014970:Xanthines / Q000494:pharmacology
D014970:Xanthines; D000242:Cyclic AMP; D006152:Cyclic GMP