[Change in the properties of plasma membranes of normal and neoplastic cells after incorporation of cholesterol].
It is shown that cholesterol incorporation into the membranes of lymphocytes, lymphoblast leikose cells L1210 and into those of ovary tumor causes an increase in the membrane phospholipid bilayer microviscosity measured by pyrene as a fluorescent probe. An increase in the membrane lipid microviscosity resulted in a decrease in the activity of Na+, K+-ATPase and 51-nucleotidase of the normal and tumor cells. After the injection of the tumor cells with an elevated cholesterol/phospholipid ratio an increase of the life span in the experimental animals as compared with the control group was observed.
D015720:5'-Nucleotidase; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D005260:Female; D007939:Leukemia L1210 / Q000378:metabolism*; D008051:Lipid Bilayers / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009708:Nucleotidases / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000378:metabolism*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014783:Viscosity
D008051:Lipid Bilayers; D002784:Cholesterol; D009708:Nucleotidases; D015720:5'-Nucleotidase; D000254:Sodium-Potassium-Exchanging ATPase
Izmenenie svoĭstv plazmaticheskikh membran normal'nykh i opukholevykh kletok pri vstraivanii kholesterina.