title: Perinatal development of the lung in rat and spiny mouse: its relation to altricial and precocial timing of birth.
abstract: Rat and spiny mouse (Acomys cahirinus) are closely related murinoid species that represent altricial (rat) and precocial (spiny mouse) modes of development. The late intrauterine developmental stages of the spiny mouse therefore seem comparable to the early extrauterine developmental stages of the rat. To elucidate the question to what extent the development of the lung is related to the developmental timing of birth, we have studied some enzymes involved in the de novo synthesis of phosphatidylcholine. Of the enzymes studied, cholinephosphate cytidylyltransferase shows peaks in activity in the perinatal period (rat and spiny mouse) and at the beginning of the 3rd postnatal week (rat only). This enzyme fulfills the requirements for a developmental parameter best as changes in activity of this enzyme can be correlated with phases of cell proliferation and surface expansion in the lung of the rat. The single peak of cholinephosphate cytidylyltransferase activity in the spiny mouse as well as microscopical examination of the lung support the hypothesis that the processes of proliferation and surface expansion, which occur consecutively in the rat, develop concurrently in the spiny mouse.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000196:embryology* / Q000254:growth & development; D002455:Cell Division; D019916:Choline-Phosphate Cytidylyltransferase; D004247:DNA / Q000378:metabolism*; D008168:Lung / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D009115:Muridae / Q000196:embryology* / Q000254:growth & development; D009713:Nucleotidyltransferases / Q000378:metabolism*; D010711:Phosphatidate Phosphatase / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D051381:Rats / Q000196:embryology* / Q000254:growth & development; D011919:Rats, Inbred Strains / Q000196:embryology / Q000254:growth & development; D013045:Species Specificity
chemical_list: D004247:DNA; D009713:Nucleotidyltransferases; D019916:Choline-Phosphate Cytidylyltransferase; D010744:Phosphoric Monoester Hydrolases; D010711:Phosphatidate Phosphatase