title: Dissolution kinetics of uric acid calculi.
abstract: Dissolution of uric acid calculi was studied in vitro. Calculated rate constants were then applied to an in vivo situation. The time required for complete dissolution of a uric acid calculus in a patient on oral alkali therapy can be estimated. Sodium bicarbonate, acetylcysteine, [tris(hydroxymethyl)aminomethane] and [tris(hydroxymethyl)aminomethane]-E were tested for relative effectiveness in dissolving uric acid calculi in vitro. In patients who require irrigation for dissolution of uric acid calculi [tris(hydroxymethyl)-aminomethane] is the preferred agent.
mesh_terms: D000111:Acetylcysteine; D001639:Bicarbonates; D004573:Electrolytes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D017693:Sodium Bicarbonate; D012965:Sodium Chloride; D012995:Solubility; D014325:Tromethamine; D014527:Uric Acid; D014545:Urinary Calculi
chemical_list: D001639:Bicarbonates; D004573:Electrolytes; D014325:Tromethamine; D014527:Uric Acid; D012965:Sodium Chloride; D017693:Sodium Bicarbonate; D000111:Acetylcysteine