[Role of cAMP-dependent phosphorylation in passive transport of Ca2+ by myocardial sarcolemma].
The myocardial sarcolemma vesicles loaded with Na2+ can accumulate Ca2+ against the concentration gradient in exchange for Na2+; the rate of this process is about 10 nmole of Ca2+ per mg of protein per min. The cAMP-dependent phosphorylation of sarcolemmal preparations has no effect on the Na+/Ca2+ exchange. At the same time the cAMP-dependent phosphorylation of protein components of the sarcolemma causes inhibition of the passive Ca2+ efflux from the vesicles depending on the degree of membrane phosphorylation.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology*; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011817:Rabbits; D012508:Sarcolemma / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology
D000001:Calcimycin; D012964:Sodium; D000242:Cyclic AMP; D011494:Protein Kinases; D002118:Calcium
Rol' cAMP-zavisimogo fosforilirovaniia v passivnom transporte Ca2+ sarkolemmoĭ miokarda.