Investigations on the activity of p-chlorophenylamide of 3-methyl-5-benzoylaminoisothiazole-4-carboxylic acid (ITCL) in the experimental keratitis.
The investigations have been carried out concerning the effectiveness of compound ITCl p-chlorophenylamide of 3-methyl-5-benzoylaminoizothiazole-4-carboxylic acid in the therapy of experimental, virus keratitis. Changes occurring on the cornea were morphologically determined and the intensity of the reaction, which per continuitatem penetrates deeper parts of the anterior eye chamber was estimated in the aqueous humor, applying biochemical factors. It has been stated that the drug in question, when applied locally, significantly weakens keratitis caused by herpes virus or by vesicular stomatitis virus. It limits the expansion of the inflammatory reaction, accelerates the reparation processes of the cornea, and causes the reparation changes not to damage the cornea optical transparence or renders the damage weaker. The conclusion has been drawn that the therapeutic effect of the drug is due to its antiviral and anti-inflammatory effect which has been revealed before.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D007634:Keratitis / Q000188:drug therapy*; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D008297:Male; D009824:Ointments; D011817:Rabbits; D013844:Thiazoles / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D009824:Ointments; D013844:Thiazoles; C027999:5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide