title: Effect of reovirus infection and dietary levels of selected vitamins on immunocompetence of chickens.
abstract: The immunocompetence of 8-week-old reovirus WVU 2937-infected and uninfected chickens fed various dietary levels of biotin, niacin, choline, or folic acid was evaluated in four experiments. Antibody production to sheep red blood cells (SRBC), wattle responses to phytohemagglutinin-P (PHA-P), and wattle responses of tuberculin-sensitized chickens to bovine-purified protein derivative (PPD) were examined in five chickens per treatment. Dietary deficiencies had no effect on the in vivo T-cell immune responses to PPD, PHA-P, or humoral hemagglutinating-antibody production to SRBC. Reovirus-infected and uninfected chickens fed biotin at double the National Research Council (1977) requirement demonstrated decreased PPD responses. Lower hemagglutinating-antibody titers in the uninfected chickens and increased titers in the infected chickens were observed in those fed 200% of the requirement of biotin when compared with the chickens fed 20% and 100% biotin diets. Reovirus infection had no effect on PPD and PHA-P responses. However, in the choline experiment, reovirus-infected chickens had elevated titers. These data indicate that reovirus infection had no adverse effect on the immunocompetence of chickens 8 weeks postinfection. Dietary deficiencies also had no adverse effect on the immunocompetence of 8-week-old reovirus-infected and uninfected chickens.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001710:Biotin / Q000494:pharmacology; D002645:Chickens; D007121:Immunocompetence / Q000187:drug effects*; D009525:Niacin / Q000494:pharmacology; D011201:Poultry Diseases / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology / Q000662:veterinary*; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D000914:Antibodies, Viral; D014815:Vitamins; D009525:Niacin; D001710:Biotin