The L1Md long interspersed repeat family in the mouse: almost all examples are truncated at one end.
We have characterized a large repetitive element which has been found at seven different locations within the beta globin locus of the BALB/c mouse. This repeat has an unusual structure in that each of the different members has the same end of the element conserved while the other end terminates at a different point in each repeat member. The sequences within the repeats from the beta globin locus have homology with other repetitive families such as the MIF-1, Bam-5, R, and the BamH1 families. These were recently proposed (T. Fanning, (1983) Nucleic Acids Res. 11, 5073-5091) to be part of a structure with the same organization which we found in the globin locus. Probing plaques from a BALB/c genomic library with sequences derived from the repeats in the globin locus shows that virtually all of the repeats from this family are organized in a manner consistent with the proposed structure.
D000818:Animals; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004622:Embryo, Mammalian; D005796:Genes; D005914:Globins / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid
D005914:Globins; D004262:DNA Restriction Enzymes