Neonatal systemic candidiasis treated with miconazole and ketoconazole.
Three infants of very low birthweight, who contracted systemic Candida albicans infections while receiving neonatal intensive care, underwent therapy with intravenously administered miconazole and orally administered ketoconazole. The drugs proved to be effective against the systemic infections with C. albicans and were well tolerated by babies. However, further trials are necessary to confirm the efficacy of these drugs in newborn infants.
D002177:Candidiasis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D007654:Ketoconazole; D008297:Male; D008825:Miconazole / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*
D007093:Imidazoles; D010879:Piperazines; D008825:Miconazole; D007654:Ketoconazole