title: [Functional characteristics of the endocrine glands in skin melanoma patients].
abstract: TI-2NOMO skin melanoma patients revealed pronounced functional disturbances of the pineal gland and pituitary-adrenal system. The decline in functional activity of the former was manifested by a decrease in urine excretion of melatonin. Enhanced levels of blood ACTH, alpha-MSH and cortisole pointed to the activation of pituitary-adrenal system which was particularly high in males. The degree of endocrine disorders was found to be in correlation with tumor stage. As far as pathogenesis of the lesion is concerned, preparations which bring function of endocrine glands to normal should be adjuvant to available treatment modalities for melanoma.
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000097:blood; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D008550:Melatonin / Q000652:urine; D008875:Middle Aged; D009367:Neoplasm Staging; D010870:Pineal Gland / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism*; D012727:Sex Characteristics; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D008550:Melatonin; D006854:Hydrocortisone
vernacular_title: Osobennosti funktsiĭ nekotorykh éndokrinnykh zhelez u bol'nykh melanomoĭ kozhi.