The protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) on irradiation-induced inhibition of intestinal transport function.
The purpose of this study was to investigate the protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) on whole-body irradiation-induced inhibition of intestinal transport function. The jejunal transport of fluid and sugars was studied in male Swiss-Webster mice before and 3 days after whole-body irradiation (1000 rads). The rates of glucose and water transport were decreased by 86 and 70%, respectively, in irradiated animals. However, the rate of transport of 3-O-methyl-D-glucose (3MG) was not affected. In mice receiving WR-2721 (500 mg/kg, ip) 15 to 30 min prior to whole-body irradiation, net water flux was unaffected and the rate of D-glucose transport was decreased only 8%. WR-2721 administered alone (500 mg/kg, ip) had no effect on either D-glucose transport or net water flux across the jejunal mucosa. The results suggest that WR-2721 protects against irradiation-induced inhibition of some intestinal transport functions.
D004999:Amifostine / Q000627:therapeutic use*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects* / Q000528:radiation effects; D007583:Jejunum / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D014867:Water / Q000378:metabolism; D014916:Whole-Body Irradiation
D009946:Organothiophosphorus Compounds; D014867:Water; D005947:Glucose; D004999:Amifostine