[Effect of cyclic nucleotides on the sensitivity of early sea urchin embryos to cytotoxic neuropharmacological preparations].
It has been shown that cytotoxic action of neuropharmacological drugs (transmitter antagonists) on early urchin embryos is reduced or abolished by cyclic nucleotides and sodium fluoride. Such a protective action differs in cAMP and dibutyryl analogs of cyclic nucleotides, depending on the chemical structure of an embryotoxic substance. It is suggested that, endogenous intracellular "prenervous" transmitters and cyclic nucleotides are interrelated in the regulation of cell division in urchin embryos.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000031:analogs & derivatives*; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology*; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D007099:Imipramine / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D012617:Sea Urchins; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014363:Tryptamines / Q000494:pharmacology*
D007211:Indoles; D012702:Serotonin Antagonists; D014363:Tryptamines; D003995:Dibutyryl Cyclic GMP; C040997:5-bromotryptamine; D003994:Bucladesine; C036467:indocate; D000242:Cyclic AMP; D006152:Cyclic GMP; D007099:Imipramine
Vliianie tsiklicheskikh nukleotidov na chuvstvitel'nost' rannykh zarodysheĭ morskikh ezheĭ k tsitoksicheskim neĭrofarmakologicheskim preparatam.