Prevalence of delta antigen/antibody in B-viral-associated hepatocellular carcinoma.
Sera from 39 patients with B-viral associated hepatocellular carcinoma were studied for the presence of delta antibody using solid-phase blocking radioimmunoassay. Only one patient (2.5%) had circulating delta antibody in the serum, and stainable delta antigen in the nuclei of the nontumor liver. A similar study of the sera of 57 patients with chronic B-viral disease without hepatocellular carcinoma revealed 18 patients (31.5%) with delta antibody. This significant difference (P less than 0.001) in the prevalence of delta antibody among these two groups is probably related to the epidemiologic background, reflected as a racial difference.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006509:Hepatitis B / Q000276:immunology; D006511:Hepatitis B Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000276:immunology; D035923:Hepatitis delta Antigens; D006801:Humans; D008113:Liver Neoplasms / Q000276:immunology*; D011863:Radioimmunoassay; D014412:Tumor Virus Infections
D000936:Antigen-Antibody Complex; D006511:Hepatitis B Antigens; D035923:Hepatitis delta Antigens