Effect of high hemicellulose corn bran in 1,2-dimethylhydrazine-induced rat intestinal neoplasia.
The incidence, distribution, size and histopathology of colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed a chemically-defined fiber-free diet or a diet containing 4.5% refined high hemicellulose corn bran with equivalent ratios of calories derived from fat, protein and carbohydrate. At an initial sacrifice period, reduced numbers of tumors were observed; however, at a later time period, no statistical differences were present compared to the fiber-free diet group. This study indicates that a high hemicellulose fiber source is protective in this animal model of experimental colonic neoplasia but this appears to reflect only a time-dependent delay in tumor detection or appearance.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology*; D004127:Dimethylhydrazines / Q000633:toxicity*; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D003313:Zea mays
D002273:Carcinogens; D004043:Dietary Fiber; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D011134:Polysaccharides; C007916:hemicellulose; D019813:1,2-Dimethylhydrazine