Reversal of haloperidol induced deficits in self-stimulation by anti-Parkinsonian drugs.
The effects of 0.1 mg/kg dose of haloperidol on self-stimulation were assessed in rats having 3 stable self-stimulation response rates of approximately 10, 50 and 100 responses per min generated by 3 levels of current intensity. Haloperidol reduced overall response rates at all current intensities and generated extinction-like response patterns. Concurrent anti-Parkinsonian (benztropine 4.0 mg/kg or diphenhydramine 4.0 mg/kg) eliminated the within session extinction performance pattern and at the highest current intensity benztropine restored self-stimulation to a non-drug performance level. These results suggested that haloperidol induced impairments in self-stimulation are secondary to a motoric rather than reinforcement dysfunction.
D000818:Animals; D001590:Benztropine / Q000494:pharmacology*; D004155:Diphenhydramine / Q000494:pharmacology*; D004558:Electric Stimulation; D005108:Extinction, Psychological / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012653:Self Stimulation / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects; D014326:Tropanes / Q000494:pharmacology*
D011954:Receptors, Dopamine; D014326:Tropanes; D001590:Benztropine; D004155:Diphenhydramine; D006220:Haloperidol