Effects of prolonged cultivation in the presence of acyclovir on recovery of latent herpes simplex virus from human trigeminal ganglia.
The continuous presence of acyclovir prevented the in vitro reactivation of latent herpes simplex virus from cultures of human trigeminal ganglia derived from 23 randomly selected cadavers. When acyclovir was withdrawn after 30 days, herpes simplex virus was recovered from 3 of 18 cases. Herpes simplex virus was recovered in 9 of 20 (45%) control cases.
D000212:Acyclovir / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D018139:Simplexvirus / Q000187:drug effects* / Q000254:growth & development; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014276:Trigeminal Nerve / Q000382:microbiology*; D014775:Virus Activation / Q000187:drug effects
D000212:Acyclovir