[In vitro activity of cefmenoxime (SCE 1365) against 616 hospital strains of gram-negative bacilli chosen for beta-lactam resistance. Comparison with cefotaxime, lamoxactam and ceftazidime].
The in vitro activity of a new cephalosporin, cefmenoxime, was tested by an agar dilution procedure against 616 strains of Gram negative rods resistant to various beta-lactams and was compared with that of cefotaxime, lamoxactam, ceftazidime (and cefsulodin against P. aeruginosa). A high activity was demonstrated on many species of tested Enterobacteriaceae including E. coli, K. pneumoniae, S. marcescens, E. cloacae resistant to the first generation cephalosporins, Proteus sp., Providencia and C. freundii, with MIC geometric mean values from 0,028 to 0,33 microgram by ml. These values were nearly similar to those given by cefotaxime or lamoxactam and inferior to those given by ceftazidime. Cefmenoxime however showed a low activity (MIC geometric means from 19,5 to 25,5 micrograms by ml) against E. cloacae resistant to second generation cephalosporins (the better agent was lamoxactam), A. calcoaceticus (the better agent was ceftazidime) and carbenicillin-resistant P. aeruginosa (here ceftazidime and cefsulodin gave better performances).
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002442:Ceftazidime; D002511:Cephalosporins / Q000494:pharmacology; D003428:Cross Infection / Q000382:microbiology; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D009070:Moxalactam / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002442:Ceftazidime; D015281:Cefmenoxime; D002439:Cefotaxime; D009070:Moxalactam
Activité in vitro de la cefménoxime (SCE 1365) sur six cent seize souches hospitalières de bacilles à gram négatif choisies pour leur résistance aux beta-lactamines. Comparison avec la céfotaxime, le lamoxactam et la ceftazidime.