title: Coronavirus replication in the intestinal and respiratory tracts during infection of calves.
abstract: Coronaviruses have been isolated from cases of neonatal calf diarrhoea in many parts of the world and were revealed in the respiratory tract recently, during a study of calf pneumonia. In experiments on gnotobiotic calves an enteric coronavirus replicated in the nasal epithelium and a respiratory isolate was shed in faeces. The enteric coronavirus prevented subsequent infection with either homologous enteric or the respiratory isolate. A dual tropism for this agent was emphasized by the detection of coronavirus antigen in intestinal and respiratory epithelium of naturally-infected calves.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D003332:Coronaviridae / Q000502:physiology*; D003333:Coronaviridae Infections / Q000382:microbiology / Q000662:veterinary*; D007422:Intestines / Q000382:microbiology; D012137:Respiratory System / Q000382:microbiology; D014779:Virus Replication