Blood platelets in psychopharmacological research.
Blood platelets are a very good model for nerve endings, for study of serotonin uptake and imipramine binding. The efficiency of various drugs, mainly antidepressants, can be evaluated using blood platelets instead of synaptosomes. A few neuronal active compounds are effective in inducing platelet secretion and shape change reaction. Platelet MAO and c-AMP levels are not yet established as useful in psychopharmacological studies.
D001321:Autistic Disorder / Q000201:enzymology; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D002352:Carrier Proteins; D003866:Depressive Disorder / Q000201:enzymology; D006801:Humans; D007099:Imipramine / Q000097:blood; D007700:Kinetics; D001523:Mental Disorders / Q000188:drug therapy / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D012559:Schizophrenia / Q000201:enzymology; D012701:Serotonin / Q000097:blood
D002352:Carrier Proteins; D011619:Psychotropic Drugs; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D012701:Serotonin; D008995:Monoamine Oxidase; D007099:Imipramine