title: Microtubular reaction in human fibroblasts infected by cytomegalovirus. Brief report.
abstract: By the use of indirect immunofluorescence it is shown that "early" functions of human cytomegalovirus induce a loss of microtubuli in human foreskin fibroblasts within 12 hours postinfection (p.i.) which persists until about 60 hours p.i. At later times p.i. microtubular structures are eventually reestablished. Following depression during the initial 48 hours p.i. tubulin synthesis in infected cells is significantly enhanced during the initial 48 hours p.i. tubulin synthesis in infected cells is significantly enhanced during the late phase of the infectious cycle suggesting that the mechanisms regulating tubulin synthesis are not impaired.
mesh_terms: D003587:Cytomegalovirus / Q000472:pathogenicity*; D003588:Cytopathogenic Effect, Viral; D005347:Fibroblasts / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006801:Humans; D008870:Microtubules / Q000648:ultrastructure*; D013997:Time Factors; D014404:Tubulin / Q000096:biosynthesis
chemical_list: D014404:Tubulin