The involvement of opioid delta-receptors in stress induced antinociception in mice.
The selective opioid delta-receptor antagonist, ICI 154,129, attenuated the antinociception, assessed by prolongation of reaction time on the hot-plate, of mice which had swum for 3 min at 20 degrees C. This stress-induced antinociception was also sensitive to naloxone suggesting the involvement of both delta- and mu-receptors. A swim of 0.5 min at 30 degrees C did not produce antinociception on the hot plate but the writhing response to i.p. acetic acid was blocked by a non-opioid mechanism.
D000818:Animals; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000502:physiology*; D017465:Receptors, Opioid, delta; D013312:Stress, Physiological / Q000503:physiopathology*; D013550:Swimming
D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D009270:Naloxone; D004743:Enkephalin, Leucine; C036405:ICI 154129