title: Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.
abstract: Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian erythroblastosis virus (AEV). In all, the peptides contain 83 amino acid residues, 74 of which are shared with v-erb-B. The AEV progenitor may have acquired the cellular gene sequences of a truncated EGF receptor (or closely related protein) lacking the external EGF-binding domain but retaining the transmembrane domain and a domain involved in stimulating cell proliferation. Transformation of cells by AEV may result, in part, from the inappropriate acquisition of a truncated EGF receptor from the c-erb-B gene.
mesh_terms: D000595:Amino Acid Sequence; D002453:Cell Cycle; D002472:Cell Transformation, Viral; D004815:Epidermal Growth Factor / Q000502:physiology; D066246:ErbB Receptors; D006801:Humans; D009857:Oncogenes; D011956:Receptors, Cell Surface / Q000302:isolation & purification
chemical_list: D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor; D066246:ErbB Receptors