Enhancement of ciliary action by a beta-adrenergic stimulant.
It is known that beta-adrenergic stimulants enhance mucociliary transport in the respiratory tract. The present study clearly indicated that such an enhancement resulted from not only the alteration in secretory function but also the direct stimulation of ciliated cells. However, the enhancement of ciliary beating depended on the morphological changes in ciliated cells. On the other hand, the effect of terbutaline aerosol, a beta-adrenergic stimulant, on patients with chronic sinusitis was evaluated by paranasal sinus radiography. Consequently, marked improvements in shadows were achieved after 4 weeks in 40% of the cases examined.
D000328:Adult; D000336:Aerosols; D000818:Animals; D002648:Child; D002908:Chronic Disease; D002923:Cilia / Q000187:drug effects*; D002925:Ciliary Motility Disorders / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000187:drug effects; D008875:Middle Aged; D011817:Rabbits; D011859:Radiography; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013726:Terbutaline / Q000627:therapeutic use*
D000336:Aerosols; D013726:Terbutaline