Identity of HeLa cell determinants acquired by vesicular stomatitis virus with a tumor antigen.
Growth of vesicular stomatitis virus (VSV) in HeLa cells results in progeny containing non-VSV antigens with a molecular weight around 75,000. The non-VSV antigens were detected by antiserums to HeLa cell determinants. These antiserums precipitate whole virions but do not neutralize them. Because one of the antiserums is directed to a tumor-specific surface antigen of HeLa cells, it appears that VSV specifically acquires such antigens during its passage through human tumor cells.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D006367:HeLa Cells / Q000382:microbiology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D008545:Melanoma / Q000276:immunology; D008970:Molecular Weight; D011817:Rabbits / Q000276:immunology; D012756:Sheep / Q000276:immunology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology*
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D007106:Immune Sera