The effect of streptozotocin-induced diabetes on prolyl hydroxylase activity in rat gingiva.
The diabetes resulted in marked decrease in prolyl hydroxylase (EC 1.14.11.2) activity in rat gingiva. Insulin treatment of diabetic rats returned the decreased enzyme activity to the level of normal controls. The results suggest that diabetes decreases the rate of collagen biosynthesis in gingival tissue by inhibiting the hydroxylation of peptidyl proline in collagen precursors.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005881:Gingiva / Q000201:enzymology*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin
D007328:Insulin; D013311:Streptozocin; D011393:Procollagen-Proline Dioxygenase