Concentration of cyclic AMP in rabbit ovaries in the preovulatory period after administration of luteinizing hormone or human chorionic gonadotrophin.
Ovarian adenosine 3'-5'-monophosphate (cAMP) concentrations were determined in untreated female rabbits and in those sacrificed at various times (0.5-6.0 h) after administration of luteinizing hormone (LH, 50 micrograms) or human chorionic gonadotrophin (hCG, 100 IU). Both LH and hCG caused a rapid increase in ovarian cAMP concentrations within 0.5 h. After LH stimulation the elevated levels declined rapidly and by 2 h they were almost back to control levels. In the hCG-treated animals the decline in ovarian cAMP from the initial peak concentrations was much more gradual and the levels were significantly higher than control even at 6 h. The different response to the two gonadotrophins is discussed in relation to the physiologic importance earlier attributed to the prolonged elevation of cAMP in rabbit ovaries after stimulation with hCG.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D007986:Luteinizing Hormone / Q000494:pharmacology*; D010053:Ovary / Q000378:metabolism*; D010060:Ovulation; D011817:Rabbits; D013997:Time Factors
D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone; D000242:Cyclic AMP