Inhibition of hepatic phosphatidylcholine synthesis by malathion in rats.
Rats maintained on a 20% casein diet were given malathion orally throughout the feeding period (100 mg/kg body weight/day, dissolved in groundnut oil). Hepatic choline kinase (EC 2.7.1.32) and cholinephosphate cytidyltransferase (EC 2.7.7.15) activities were inhibited, whereas cholinephosphotransferase (EC 2.7.8.2) activity was not affected by malathion administration. Incorporation of [methyl-14C]L-methionine into hepatic microsomal phosphatidylcholine was significantly reduced by malathion administration.
D000818:Animals; D002250:Carbon Radioisotopes / Q000378:metabolism; D002794:Choline / Q000031:analogs & derivatives / Q000378:metabolism; D002797:Choline Kinase / Q000037:antagonists & inhibitors; D019916:Choline-Phosphate Cytidylyltransferase; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
D002250:Carbon Radioisotopes; D010713:Phosphatidylcholines; C017506:methylcholine; D014316:Tritium; D008715:Methionine; C038344:methionine methyl ester; D002797:Choline Kinase; D009713:Nucleotidyltransferases; D019916:Choline-Phosphate Cytidylyltransferase; D002794:Choline; D008294:Malathion