Localization of angiotensin II binding sites in rat septum by autoradiography.
The distribution of septal [125I]angiotensin II (Ang II) binding sites localized by light microscopic autoradiography was compared with the distribution of septal immunoreactive Ang II-containing nerve terminals localized by immunohistochemistry. Within the septum, both the [125I]Ang II binding sites and Ang II-like immunoreactive terminals were restricted to the lateral septal nucleus. The close parallel between the distribution of [125I]Ang II binding sites and immunoreactive Ang II nerve terminals in the lateral septum suggests that central Ang II receptors may be functionally linked to neuronally released Ang II.
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012686:Septal Nuclei / Q000378:metabolism; D012688:Septum Pellucidum / Q000378:metabolism*
D011945:Receptors, Angiotensin; D011956:Receptors, Cell Surface; D000804:Angiotensin II