Value of the 30 min ACTH-test in assessing hypothalamic-pituitary-adrenocortical function after pituitary surgery in Cushing's disease.
Adrenocortical responses to a 30 min ACTH-test were measured before pituitary surgery and 8-12 d, 2-3 months and 6 months after, in 13 patients with Cushing's disease. The decrease in adrenocortical response to the short ACTH-test performed 8-12 d postoperatively correlated with the outcome as assessed 6 months after surgery. Adrenocortical response to ACTH became subnormal or borderline 8-12 d after surgery in patients demonstrating postoperative HPA insufficiency. These results add further support to the value of the short ACTH-test in assessing integrated HPA function in various clinical situations.
D000302:Adrenal Cortex / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone; D003480:Cushing Syndrome / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism; D007016:Hypophysectomy; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011184:Postoperative Period
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone