title: [Application of the methods of the mathematical theory of experiments to the development of multicomponent radioprotective preparations].
abstract: A study was made of the possibility of using a mathematical theory of experiment in developing effective many-component radioprotective preparations. The preparations composed of cystamine or S-(omega-aminopropyl)-beta-aminoethyl thiophosphate, as the basis, and mexamine, ethyron and gutimine were used as an example to prove the adequacy of such an approach in solving the problems of optimization of composing the radioprotective complexes according to their efficiency and toxicity.
mesh_terms: D008735:5-Methoxytryptamine / Q000008:administration & dosage; D004999:Amifostine / Q000008:administration & dosage; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003538:Cystamine / Q000008:administration & dosage; D006164:Guanylthiourea / Q000008:administration & dosage; D007550:Isothiuronium / Q000008:administration & dosage / Q000031:analogs & derivatives; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use
chemical_list: D011837:Radiation-Protective Agents; D007550:Isothiuronium; C007687:etiron; D008735:5-Methoxytryptamine; D006164:Guanylthiourea; D004999:Amifostine; D003538:Cystamine
vernacular_title: Primenenie metodov matematicheskoĭ teorii éksperimenta pri razrabotke mnogokomponentnykh radiozashchitnykh retseptur.