Co-ordinated regulation of muscle glycolysis and hepatic glucose output in exercise by catecholamines acting via alpha-receptors.
Recent findings indicate that glucose uptake by contracting hindlimb #Acta Physiol. Scand. (1982) 116, 215-222 #and heart #Biochem. Biophys. Res. Commun. (1982) 108, 124-131 # of the rat is stimulated by epinephrine acting through alpha-adrenergic mechanisms. Since in exercise hepatic glucose output may be increased markedly by activation of alpha-adrenergic receptors and matched by the increase in muscle glucose uptake (maintaining blood glucose levels relatively constant), it is now proposed that a general coordination of glucose metabolism may operate via alpha-adrenergic receptor mechanisms. The basis for this proposal is discussed.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D005943:Gluconeogenesis; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D008112:Liver Glycogen / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D005082:Physical Exertion; D051381:Rats; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*
D002395:Catecholamines; D008112:Liver Glycogen; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D005947:Glucose