Dissolution rates of corticoid solutions dispersed on silicas.
Two nonporous and three porous amorphous silicas were used as dispersion media to convert corticoid solutions into free-flowing powders. The corticoids (prednisone, prednisolone, and hydrocortisone) were dissolved in N,N-dimethylacetamide-polyethylene glycol 400 (7:3 v/v) and their 10% (w/v) solutions were mixed with the silicas (1:3 v/w). Dissolution rates of the corticoids from such powdered solutions were more rapid than their micronized powders in various aqueous media.
D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone; D011239:Prednisolone; D011241:Prednisone; D012822:Silicon Dioxide; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D000305:Adrenal Cortex Hormones; D012822:Silicon Dioxide; D011239:Prednisolone; D011241:Prednisone; D006854:Hydrocortisone