[Effect of arteparon on the formation of calcium phosphate and calcium pyrophosphate crystals--comparative experimental study].
The influence of Arteparon on crystal formation in vitro has been examined in calcium orthophosphate and in calcium pyrophosphate mixtures. Similar factors may be operative in the cartilage calcification processes, and thus in chondrocalcinosis. Authors have ascertained that Arteparon - like chondroitin sulphate - inhibits crystal separation. The optimal concentration for this inhibition lies in the range of the proteoglycan content of normal cartilage. Where there are physiological phosphate-pyrophosphate ratios and a low magnesium concentration, it is certain that Arteparon has an inhibiting effect. Apart from the spatial structure of the substance, the importance of negative charge density for the inhibition of separation of calcium phosphate and pyrophosphate crystals is thought to contribute to this effect of Arteparon.
D002130:Calcium Phosphates / Q000378:metabolism*; D002131:Calcium Pyrophosphate / Q000378:metabolism*; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism; D002805:Chondrocalcinosis / Q000188:drug therapy / Q000378:metabolism; D003460:Crystallization; D011756:Diphosphates / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006801:Humans
D002130:Calcium Phosphates; D011756:Diphosphates; D006025:Glycosaminoglycans; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C010034:Arteparon; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D002131:Calcium Pyrophosphate
Wirkung von Arteparon auf die Bildung von Calciumphosphat- und Calciumpyrophosphatkristallen--Vergleichende experimentelle Untersuchung.