Acute administration of high doses of estrogen increases glucose utilization throughout brain.
The effects of high intravenous doses of estradiol benzoate on local cerebral glucose utilization were studied by the [14C]2-deoxyglucose method in conscious ovariectomized adult rats. Statistically significant increases in glucose utilization averaging 20% were observed in 42 of 60 anatomically discrete regions of the estrogen-treated animals. The possible role of catechol estrogen, a potent inhibitor of catechol-O-methyltransferase, in these effects is considered.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D002393:Estrogens, Catechol / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D008473:Median Eminence / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002393:Estrogens, Catechol; D004958:Estradiol; D002394:Catechol O-Methyltransferase; D005947:Glucose