[Mechanism of the pro-oxidant activity of tetracycline].
It was shown on male rats that like ethanol tetracycline increased lipid peroxidation (LPO) in the hepatocyte membranes, evident from increased levels of diene conjugates and malone dialdehyde in the liver homogenates, especially on their combination. The signal amplitude of the EPR-forms of cytochrome P-450 and Cu-, Mo- and Fe-containing proteins did not change, while the content of the EPR-forms of the free radicals increased. High efficiency of antioxidants, such as tocopherol acetate, sodium selenite and tincture of Astragalus L. is indirect evidence of the role of the free radicals in initiation of LPO in tetracycline affections of the liver.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D003576:Electron Transport Complex IV / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D005609:Free Radicals; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D013752:Tetracycline / Q000494:pharmacology*
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D000431:Ethanol; D003577:Cytochrome P-450 Enzyme System; D003576:Electron Transport Complex IV; D013752:Tetracycline
O mekhanizme prooksidantnogo deĭstviia tetratsiklina.