Control of mouse hepatitis virus replication in macrophages by a recessive gene on chromosome 7.
We have identified and mapped a new locus that imparts resistance to productive infection of mouse hepatitis virus MHV(A59) in cultured macrophages. This locus maps 41.5 centimorgans from the albino locus on chromosome 7.
D000375:Aging; D000818:Animals; D002874:Chromosome Mapping; D004198:Disease Susceptibility; D005808:Genes, Recessive; D006524:Hepatitis, Viral, Animal / Q000235:genetics / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology* / Q000502:physiology; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D006517:Murine hepatitis virus / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity; D014779:Virus Replication