(Na+,K+)-ATPase stimulation by sucrose feeding: prevention by 6-hydroxydopamine.
The effects of sucrose feeding on parameters associated with (Na+,K+)-ATPase in brown adipose tissue were compared in rats treated with parenteral 6-hydroxydopamine and vehicle. Sucrose feeding significantly increased K+-p-nitrophenylphosphatase and ouabain binding in brown adipose tissue from rats treated with vehicle. By contrast, sucrose feeding had no effects on these measurements in rats treated with parenteral 6-hydroxydopamine. 6-hydroxydopamine did not significantly alter sucrose consumption and there were no significant effects on weight gain during the short experimental period.
D009597:4-Nitrophenylphosphatase / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D010042:Ouabain / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013395:Sucrose / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D006892:Hydroxydopamines; D013395:Sucrose; D010042:Ouabain; D016627:Oxidopamine; D009597:4-Nitrophenylphosphatase; D000254:Sodium-Potassium-Exchanging ATPase; D009638:Norepinephrine