Cytochrome P-450-dependent xenobiotic metabolizing activity in Zymbal's gland, a specialized sebaceous gland of rodents.
Homogenates of Zymbal's glands from beta-naphthoflavone-treated rats and mice have 7-ethoxycoumarin O-deethylase activity, while those from rats also have aryl hydrocarbon hydroxylase activity. Measured concentrations of cytochrome P-450 in microsomes from Zymbal's glands of beta-naphthoflavone-treated rats are not higher than those from untreated rats. Studies of inhibitors of 7-ethoxycoumarin O-deethylation and aryl hydrocarbon hydroxylation in homogenates of Zymbal's glands from beta-naphthoflavone-treated rats suggest that these enzyme activities are catalyzed by cytochrome P-450. These findings indicate that reactive metabolites of chemical carcinogens may be formed in Zymbal's gland, a target organ for chemical carcinogenesis.
D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D001564:Benzo(a)pyrene; D001571:Benzoflavones / Q000494:pharmacology; D001580:Benzopyrenes / Q000378:metabolism; D003374:Coumarins / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008297:Male; D051379:Mice; D008812:Mice, Hairless / Q000378:metabolism*; D008861:Microsomes / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012627:Sebaceous Glands / Q000201:enzymology*; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D001580:Benzopyrenes; D003374:Coumarins; C017299:7-ethoxycoumarin; D001564:Benzo(a)pyrene; D019324:beta-Naphthoflavone; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase