[Rabbit brain tumor model].
We have established the rabbit brain tumor model. The domestic rabbits (Japanese White) inplanted the VX2 rabbit epidermoid carcinoma cell were died within three weeks after the inplantation. These brains showed massive brain tumor remarkably infiltrating into the surrounding brain. The flowcytometry of intracerebral VX2 tumor revealed a monopeak at the 2C and relatively large amount of S-phase cells. We think that this brain tumor model is more convenient for the combination treatment with operation and chemotherapy, because the rabbit brain is larger and intravenous injection is more easy than the rat or mouse.
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D012777:Cottontail rabbit papillomavirus; D004273:DNA, Neoplasm / Q000378:metabolism; D005434:Flow Cytometry; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D011817:Rabbits
D004273:DNA, Neoplasm