title: The brain amino acid pattern in experimental coma due to phenytoin in guinea pigs.
abstract: An experimental study was carried out on 50 guinea pigs to evaluate the amino acid pattern in the whole brain after a toxic dose of phenytoin (1 g . kg-1 body wt). One group of 25 guinea pigs was treated with the drug which made them comatose, and their brains removed by craniotomy and frozen in liquid nitrogen; 25 guinea pigs were used as a control group. The brain amino acid pattern was determined by ion-exchange chromatography. All the amino acids, except threonine and methionine, decreased. Hypotheses about the particular cerebral metabolic pathways involved are discussed.
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002852:Chromatography, Ion Exchange; D003128:Coma / Q000139:chemically induced* / Q000378:metabolism; D006168:Guinea Pigs; D010672:Phenytoin
chemical_list: D000596:Amino Acids; D010672:Phenytoin