title: Effect of ethyl cellulose in a medium-chain triglyceride on the bioavailability of ceftizoxime.
abstract: The oral bioavailability of new formulations of ceftizoxime sodium was investigated in animals and humans. In rats, one of the formulations tested showed significant improvement, with a urinary excretion of 47.7% (0--24 hr). Good results were obtained also in dogs. In humans, the mean peak serum level was 3.6 micrograms/ml at 3.3 hr postadministration for formulation 10. The average ceftizoxime AUC at 0--8 hr was 17.3 micrograms hr/ml and urinary excretion of ceftizoxime was 9.6% (0--24 hr). The concentrations in the serum exceeded the minimum inhibitory concentrations for most of the commonly encountered bacterial pathogens.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000818:Animals; D001682:Biological Availability; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D015296:Ceftizoxime; D002482:Cellulose / Q000031:analogs & derivatives* / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D014677:Pharmaceutical Vehicles; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000494:pharmacology*
chemical_list: D014677:Pharmaceutical Vehicles; D014280:Triglycerides; C013517:ethyl cellulose; D002482:Cellulose; D015296:Ceftizoxime; D002439:Cefotaxime