Complete amino acid sequence of the nucleic acid-binding protein of bovine leukemia virus.
The complete amino acid sequence of the nucleic acid-binding protein p12 of bovine leukemia virus (BLV) has been determined. Peptides were generated by enzymatic digestion and formic acid cleavage, purified by reversed-phase liquid chromatography and subjected to automated Edman degradation. BLV p12 is a proline-rich linear polypeptide composed of 69 amino acids with Mr 7558. A comparison of the p12 structure to that of the avian and murine type C retroviral nucleic acid-binding proteins shows significant homology only in the putative binding domain. This conserved region is duplicated BLV p12 as in the avian homolog.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001358:Avian Sarcoma Viruses / Q000032:analysis; D015683:Gene Products, gag; D001909:Leukemia Virus, Bovine / Q000032:analysis*; D009052:Leukemia Virus, Murine / Q000032:analysis; D010446:Peptide Fragments; D012190:Retroviridae / Q000032:analysis*; D014764:Viral Proteins / Q000032:analysis*
D000596:Amino Acids; D015683:Gene Products, gag; D010446:Peptide Fragments; D014764:Viral Proteins