Comparison of iprindole, imipramine and mianserin action on brain serotonergic and beta adrenergic receptors.
Iprindole in vitro displaces mianserin from specific recognition sites (IC50 3 microM). Daily doses (5 mg/kg i.p.) of iprindole repeated for 3 weeks attenuate the norepinephrine stimulation of adenylate cyclase studied in brain slices. Whereas the attenuation of noradrenergic receptor function elicited by imipramine can be antagonized by lesions of serotonergic axons, the inhibition of norepinephrine-induced stimulation of adenylate cyclase elicited by iprindole or mianserin is not inhibited by serotonin axon lesions. Iprindole given daily repeatedly reduces the maximal number of binding sites of [3H]mianserin and [3H]ketanserin; both actions are unchanged by lesions of central serotonergic axons.
D000818:Animals; D001369:Axons / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000096:biosynthesis; D003984:Dibenzazepines / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007488:Iprindole / Q000494:pharmacology*; D007650:Ketanserin; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010880:Piperidines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*
D003984:Dibenzazepines; D007211:Indoles; D010880:Piperidines; D011943:Receptors, Adrenergic, beta; D011985:Receptors, Serotonin; D008803:Mianserin; D007488:Iprindole; D007650:Ketanserin; D000242:Cyclic AMP; D007099:Imipramine; D009638:Norepinephrine