The elevation of blood levels of zinc protoporphyrin in mice following whole body irradiation.
Elevation of zinc protoporphyrin (ZPP) levels in the blood has served as an indicator of lead poisoning and iron deficiency anemia for many years. We have discovered that sublethal doses of whole body irradiation with x-rays also elevates ZPP 2-3-fold over normal levels. The ZPP level does not begin to increase until days 12-14 postirradiation and peaks between days 18 and 20 before returning to normal levels between days 28 and 35. Increasing the radiation dose delays the onset of the rise in ZPP, but does not affect the magnitude of the elevation. At lethal doses, ZPP elevation is not observed. Neither of the two previously described mechanisms that cause elevations of ZPP, namely iron deficiency and inhibition of ferrochelatase, are responsible for the radiation-induced elevation of ZPP. The elevation of ZPP appears to be correlated with the recovery of the hematopoietic system from radiation injury.
D004999:Amifostine / Q000494:pharmacology; D000818:Animals; D001663:Bilirubin / Q000097:blood / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004909:Erythrocyte Indices / Q000528:radiation effects; D004920:Erythropoiesis / Q000528:radiation effects*; D005294:Ferrochelatase / Q000097:blood / Q000528:radiation effects; D007501:Iron / Q000097:blood / Q000528:radiation effects; D007855:Lead Poisoning / Q000097:blood; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood* / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D013156:Splenectomy; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D011166:Porphyrins; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007501:Iron; D005294:Ferrochelatase; D004999:Amifostine; D001663:Bilirubin