[Mechanism of action of benzothiadiazides in arterial hypertension: the energetic theory].
Hydrochlorothiazide, tienilic acid, chlorthalidone and indapamide inhibit membrane adenylate cyclase of pigeon erythrocytes in vitro. This effect is related to the action of these substances on the interface between the membranous phospholipids and adenylate cyclase. Indapamide with its strong lipophic properties, has a more specific action on the intracellular regulation of adenylate cyclase. The relationship between the inhibition of adenylate cyclase and the antihypertensive effects of these drugs is discussed.
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D002752:Chlorthalidone / Q000494:pharmacology; D010856:Columbidae; D000242:Cyclic AMP / Q000032:analysis; D004232:Diuretics / Q000494:pharmacology*; D004734:Energy Metabolism; D004910:Erythrocyte Membrane / Q000201:enzymology; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000494:pharmacology; D013989:Ticrynafen / Q000494:pharmacology
D000067956:Adenylyl Cyclase Inhibitors; D004232:Diuretics; D006852:Hydrochlorothiazide; D000242:Cyclic AMP; D007190:Indapamide; D013989:Ticrynafen; D002752:Chlorthalidone
Recherche du mécanisme d'action des benzothiadiazides dans l'hypertension artérielle: l'hypothèse énergétique.