Chronic RO 15-1788 treatment increases the number of benzodiazepine receptors in rat cerebral cortex and hippocampus.
Administration of 4 mg/kg per day of diazepam in the drinking water for 14 days produced a small, but not significant decrease of benzodiazepine binding sites for [3H]flunitrazepam and [3H]ethyl-beta-carboline-3-carboxylate. Similar treatment with the benzodiazepine antagonist RO 15-1788 resulted in a marked increase in the density of sites for both ligands in the synaptosomal membranes of cerebral cortex and hippocampal formation.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005442:Flumazenil; D005445:Flunitrazepam / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D011963:Receptors, GABA-A
D001570:Benzodiazepinones; D002243:Carbolines; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005442:Flumazenil; D005445:Flunitrazepam; C024915:beta-carboline-3-carboxylic acid ethyl ester