Oxy-radical toxicity in catecholamine neurons.
This article summarizes the evidence that oxy-radicals are involved in the destruction of catecholamine neurons by polyphenolic neurotoxins. Superoxide-mediated damage by 6-hydroxydopamine can be suppressed by intracellular catecholamines, which act as scavengers of the superoxide radical. Administration of exogenous hydroxyl radical-scavenging agents protects peripheral sympathetic neurons from destruction by 6-hydroxydopamine, 6- aminodopamine or 5,7-dihydroxytryptamine. Intraneuronal monoamine oxidase may drive cellular senescence of the nigrostriatal tract in patients with Parkinson's disease by generating hydrogen peroxide and derived oxy-radicals during the metabolism of endogenous dopamine.
D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D004298:Dopamine / Q000031:analogs & derivatives / Q000633:toxicity; D005609:Free Radicals; D006801:Humans; D006892:Hydroxydopamines / Q000633:toxicity; D006900:Hydroxylation; D008995:Monoamine Oxidase / Q000378:metabolism; D009474:Neurons / Q000502:physiology*; D016627:Oxidopamine; D010100:Oxygen / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism; D013481:Superoxides / Q000633:toxicity
D002395:Catecholamines; D005609:Free Radicals; D006892:Hydroxydopamines; D013481:Superoxides; C006532:6-aminodopamine; D016627:Oxidopamine; D008995:Monoamine Oxidase; D010100:Oxygen; D004298:Dopamine