title: Studies on beta-endorphin and membrane-bound calcium interaction using chlorotetracycline (CTC) as a fluorescence probe.
abstract: Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mitochondria. It seems that the binding pattern or interaction of beta-endorphin with synaptosomes and erythrocytes are characteristically different from that of mitochondria, indicating some functional significance of this differential interaction.
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002751:Chlortetracycline; D004723:Endorphins / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000378:metabolism; D005456:Fluorescent Dyes; D066298:In Vitro Techniques; D008297:Male; D008566:Membranes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D005456:Fluorescent Dyes; D001615:beta-Endorphin; D002118:Calcium; D002751:Chlortetracycline