Characterization of a kappa-agonist-like antinociceptive action of tifluadom.
The novel benzodiazepine tifluadom was compared with a selection of proposed mu- and kappa-opiate agonists using a combined heat/pressure nociceptive paradigm. Calculation of the relative potency ratios to the nociceptive stimuli revealed a distinction between mu- and kappa-agonists. The potency ratio yielded by tifluadom coincided with that displayed by the kappa-agonists and this finding is discussed in relation to morphine withdrawal and radioligand binding studies.
D000700:Analgesics; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D051379:Mice; D011957:Receptors, Opioid / Q000187:drug effects*; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu
D000700:Analgesics; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D001569:Benzodiazepines; C035470:tifluadom