[Possible role of somatotropic hormone in regulating the functional state of glial cells in the central nervous system].
Experiments were made to study the actions of STH and its fragment capable to stimulate the growth processes on MAO activity and selective binding of catecholamines by alpha- and beta-adrenoreceptors in glial cells of the rat brain cortex. For comparison the effects of STH and its fragment on 3H-PGE1 binding were studied. STH and its fragment were found to produce no influence on MAO activity or specific binding of 3H-PGE1 with glial cells. STH and its fragment (5.10(-9) M) were found to reduce specific binding of 3H-dihydroergocryptine with beta- and alpha-adrenoreceptors of glial cells, respectively. It is suggested that STH and its fragment can modulate the function of glial cells by changing the selective action of catecholamines on subpopulations of adrenergic receptors.
D000527:Alprostadil; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004082:Dihydroalprenolol / Q000378:metabolism; D004088:Dihydroergotoxine / Q000378:metabolism; D013006:Growth Hormone / Q000502:physiology*; D066298:In Vitro Techniques; D008995:Monoamine Oxidase / Q000378:metabolism; D009457:Neuroglia / Q000502:physiology*; D010446:Peptide Fragments / Q000502:physiology; D011458:Prostaglandins E / Q000378:metabolism; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism
D010446:Peptide Fragments; D011458:Prostaglandins E; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; C033194:somatotropin fragment 77-107; D004088:Dihydroergotoxine; D004082:Dihydroalprenolol; D013006:Growth Hormone; D008995:Monoamine Oxidase; D000527:Alprostadil
O vozmozhnoĭ roli somatotropnogo gormona v reguliatsii funktsional'nogo sostoianiia kletok glii v tsentral'noĭ nervnoĭ sisteme.