AUS in the prevention of Marek's disease.
Aminoureidosulfone (AUS) was used as a feed additive to prevent mortality in Marek's disease (MD)-infected chickens in the laboratory. Chicks infected with MD virus (5000 plaque-forming units) at 1 day of age were given AUS in the feed from 1 day of age until the experiment was terminated. AUS, at all concentrations tested, reduced mortality due to Marek's disease. Chickens receiving AUS at the 0.002% level had a 4% mortality rate, those receiving 0.005% had 9% mortality, and those receiving 0.01% had 2% mortality; mortality rates in the respective controls were 44%, 49%, and 50%. However, lesion reduction in surviving chicks was minimal. When AUS was withdrawn from the feed, MD-induced mortality increased within two weeks; average body weight decreased also.
D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D003622:Dapsone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008381:Herpesvirus 2, Gallid / Q000187:drug effects / Q000472:pathogenicity; D008380:Marek Disease / Q000517:prevention & control*; D011201:Poultry Diseases / Q000517:prevention & control*; D014774:Virulence
D000998:Antiviral Agents; D005503:Food Additives; C006564:4-amino-p'-ureidodiphenylsulfone; D003622:Dapsone