[Transport of calcium ions and content of cyclic nucleotides in fibroblast cultures from skin of patients with rheumatoid arthritis].
Content of cyclic nucleotides and the rate of Ca2+ transport into cells were studied in fibroblast cultures from skin of patients with rheumatoid arthritis within II-VI transfers during the stationary phase of growth. There were no differences as compared with controls. Effect of adrenaline on cAMP content was decreased as compared with the controls and the hormone influence on the rate of Ca2+ transport was dissimilar: in 5 patients out of the group of 13 persons--there was noted a stimulating effect (it was the case as in healthy persons), while in other patients the effect was either absent or adrenaline inhibited the Ca2+ transport. Similarly, in rheumatoid arthritis estradiol either did not affect the Ca2+ transport or its effect was opposite as compared with the normal state. The data obtained are discussed in comparison with the results on systemic sclerodermia published earlier.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012867:Skin / Q000378:metabolism*
D000242:Cyclic AMP; D002118:Calcium; D004837:Epinephrine
Transport ionov kal'tsiia i soderzhanie tsiklicheskikh nukleotidov v kul'turakh fibroblastov kozhi bol'nykh revmatoidnym artritom.