title: Vaccination of cows with a combined rotavirus/enterotoxigenic "E. coli" K99 vaccine to protect newborn calves against diarrhoea.
abstract: The protective effect of a combined rotavirus/enterotoxigenic E. coli K99 vaccine against naturally occurring neonatal diarrhoea was evaluated in two dairy and two beef herds. Before vaccination, frequency of diarrhoea in these herds was 46% up to 60% with losses of 7% to 20%. After vaccination of pregnant cows and heifers mild diarrhoea occurred in 14% to 20% of their calves, one out of 144 calves died with enteric symptoms. In 13 out of 26 calves of nonvaccinated controls where diarrhoea was noted, one of them died. K99-positive enterotoxigenic E. coli were not detected in any of the faeces tested. Rotavirus was found in one of the beef herds.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D003126:Colostrum / Q000276:immunology; D003967:Diarrhea / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D007112:Immunity, Maternally-Acquired; D008892:Milk / Q000276:immunology; D011247:Pregnancy; D012401:Rotavirus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines