[Cholestatic hepatitis. Presumptive role of ticlopidine].
A seventy-one-year-old woman presented with jaundice (total bilirubinemia 91 microM, conjugated bilirubinemia 76 microM) and cytolysis (ALAT greater than 6 N) after ten days of pentoxifylline-ticlopidine combination therapy. Blood count was normal excepting transient anemia. Protein electrophoresis was normal. Jaundice resolved 10 days after both drugs had been discontinued. Viral serology (B, A, nonA-nonB, mononucleosis, cytomegalovirus, herpes simplex virus) was negative. Ultrasonography and cholecystography were normal. Responsibility of a drug is therefore likely and we are inclined to incriminate ticlopidine as two similar cases have previously been observed.
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D013876:Thiophenes / Q000009:adverse effects*; D013988:Ticlopidine
D013876:Thiophenes; D013988:Ticlopidine
Hépatite cholestatique: rôle vraisemblable de la ticlopidine.