[Toxicity of Bordetella pertussis suspensions associated with the preparation of pertussis vaccine].
The process of the detoxication of B. pertussis suspensions during their storage has a wave-like character and is determined by changes in the levels of the toxicity of the soluble and corpuscular fractions. Conditions facilitating the transition of toxic cellular products into the soluble state may lead to the increase of the toxic activity of pertussis vaccines.
D000818:Animals; D001886:Bordetella pertussis / Q000472:pathogenicity*; D004356:Drug Storage; D051379:Mice; D010567:Pertussis Vaccine / Q000633:toxicity*; D012995:Solubility; D013535:Suspensions; D013997:Time Factors
D010567:Pertussis Vaccine; D013535:Suspensions
Izuchenie toksichnosti suspenziĭ Bordetella pertussis v sviazi s izgotovleniem kokliushnoĭ vaktsiny.