Determination of the molecular size of the nitrendipine-sensitive Ca2+ channel by radiation inactivation.
The molecular size of the [3H] nitrendipine receptor of transverse tubules prepared from rabbit skeletal muscle and from rat cortex synaptic membranes have been investigated. Radiation inactivation of the specific binding of [3H] nitrendipine was consistent with Mr equals 210 000 +/- 20,000 for the receptor in each membrane preparation indicating a common size for the [3H] nitrendipine receptor.
D000818:Animals; D001665:Binding Sites / Q000528:radiation effects; D001923:Brain Chemistry; D002415:Cats; D004307:Dose-Response Relationship, Radiation; D007473:Ion Channels / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D008970:Molecular Weight; D009132:Muscles / Q000378:metabolism / Q000528:radiation effects; D009543:Nifedipine / Q000031:analogs & derivatives / Q000378:metabolism*; D009568:Nitrendipine; D011725:Pyridines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes / Q000378:metabolism / Q000528:radiation effects
D007473:Ion Channels; D011725:Pyridines; D009568:Nitrendipine; D009543:Nifedipine