title: Variation in human herpesvirus susceptibility to enhancement by the pesticide carbaryl.
abstract: The ability of various human herpesviruses to be enhanced by the pretreatment of human embryonic lung cells with the pesticide carbaryl (1-naphthyl-N-methyl-carbamate) differs according to the virus tested. Different strains of varicella-zoster virus produced different patterns of susceptibility to enhancement. Laboratory-adapted strains were less sensitive to enhancement than were wild-type strains recently isolated from clinical specimens. The related human herpes simplex viruses types 1 and 2 and cytomegalovirus were negative for susceptibility to enhancement when either laboratory-adapted or wild-type strains were tested. No difference in the pattern of susceptibility was detected whether virus yields were determined by cell-associated or cell-free virus assay or when the input multiplicity was varied 10-fold.
mesh_terms: D012721:Carbaryl / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D008168:Lung / Q000196:embryology; D018139:Simplexvirus / Q000187:drug effects / Q000502:physiology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D012721:Carbaryl