Cardiac arrhythmogenic action of benzo(a)pyrene in the rabbit.
Rabbits treated with benzo(a)pyrene developed cardiac arrhythmias when exposed by inhalation to 8100 ppm trichloroethylene or 15000 ppm halothane to a greater extent and at lower doses of epinephrine challenge than did controls. Benzo(a)pyrene and 3-methylcholanthrene both increased the metabolism of trichloroethylene, but 3-methylcholanthrene did not increase its cardiotoxic effect. The basis of the arrythmogenic action of benzo(a)pyrene appears to be unrelated to its ability to induce xenobiotic metabolism.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000633:toxicity*; D004837:Epinephrine / Q000494:pharmacology; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives / Q000097:blood; D006221:Halothane / Q000097:blood / Q000633:toxicity; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D010634:Phenobarbital / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors; D014238:Trichloroacetic Acid / Q000097:blood; D014241:Trichloroethylene / Q000378:metabolism
D001580:Benzopyrenes; D014241:Trichloroethylene; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene; D014238:Trichloroacetic Acid; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol; D006221:Halothane; D004837:Epinephrine; D010634:Phenobarbital