title: Ranitidine does not affect gonadal function in man.
abstract: We studied the effect of ranitidine on gonadal function in 20 male subjects with chronic duodenal ulcer. Eleven were treated with ranitidine 150 mg twice daily for 3 months and 150 mg at night for 9 months, nine with placebo for 3 months. Similar to placebo, treatment with ranitidine did not influence basal serum concentrations of testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL). No significant changes were found in sperm concentration, motility or morphology. Ranitidine does not affect gonadal function in man.
mesh_terms: D000293:Adolescent; D000328:Adult; D004381:Duodenal Ulcer / Q000188:drug therapy; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D011899:Ranitidine / Q000009:adverse effects* / Q000627:therapeutic use; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
chemical_list: D012739:Gonadal Steroid Hormones; D013739:Testosterone; D011899:Ranitidine; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone