The effects of selective immunosuppression on resistance to Mesocestoides corti in strains of mice showing high and low initial susceptibility.
Previous work has shown that C57BL/6 mice had the lowest initial susceptibility to Mesocestoides corti of six strains of mice examined. Parasite burdens in this strain and in CBA/H mice, a strain showing a higher initial susceptibility to M. corti, were compared following selective immunosuppressive treatments. Irradiation, splenectomy and the administration of cyclophosphamide and methyl prednisolone all resulted in higher parasite burdens in C57BL/6 mice. In contrast these treatments had a minimal effect on parasite burdens in CBA/H mice. In the light of these results the role of antibody in controlling parasite proliferation is discussed.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000818:Animals; D002589:Cestoda / Q000187:drug effects / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology / Q000469:parasitology; D008808:Mice, Inbred CBA / Q000276:immunology / Q000469:parasitology; D008815:Mice, Inbred Strains / Q000276:immunology / Q000469:parasitology*; D012822:Silicon Dioxide / Q000494:pharmacology; D013156:Splenectomy
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D012822:Silicon Dioxide; D003520:Cyclophosphamide