Pharmacological evidence of the stimulation of central alpha-adrenergic receptors.
We studied the interactions between CRL 40028 (benzhydryl sulfinyl) acetohydroxamic acid) and the alpha 1 blocker prazosin, in mouse. CRL 40028 antagonizes prazosin-induced hypothermia and hypomotility; prazosin antagonizes the anticonvulsant effect of CRL 40028 in the quaking mouse.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D006877:Hydroxamic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008821:Mice, Quaking; D009043:Motor Activity / Q000187:drug effects; D009115:Muridae; D011224:Prazosin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced
D006877:Hydroxamic Acids; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; C022116:adrafinil; D011224:Prazosin