Cytotoxic effects of aramid fibres on rat pulmonary macrophages: comparison with chrysotile asbestos.
Aramid fibres have been proposed as a substitute for many asbestos uses. Although dimensional characteristics of aramid fibres vary with the type of application, some of the commercial grades proposed contain fibres whose geometry is clearly in a range where biological reactivities have been reported for other natural or man-made fibres. We wish to report that short aramid fibres, when tested on cultures of rat pulmonary alveolar macrophages (PAMs), induce the commonly recognized signs of a cytotoxic effect, that is: leakage of cytoplasmic and lysosomal marker enzymes, concomittant with a decreased ATP cell content.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D017632:Asbestos, Serpentine; D003593:Cytoplasm / Q000201:enzymology; D066298:In Vitro Techniques; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D011108:Polymers / Q000633:toxicity*; D011650:Pulmonary Alveoli / Q000166:cytology / Q000187:drug effects*; D051381:Rats
D017632:Asbestos, Serpentine; C039578:Kevlar Aramid fibers; D011108:Polymers; D001194:Asbestos; D000255:Adenosine Triphosphate