Infection of mouse lymphocytes by Epstein-Barr virus. II. Stimulation of cellular DNA synthesis by EBV in the absence of EBNA induction and cell transformation.
Epstein-Barr virus (EBV) of the transforming and nontransforming strains induced transient stimulation of cellular DNA synthesis during lytic infection of normal mouse lymphocytes. In contrast to human B lymphocytes, the action of both EBV strains in mouse cells was additive. The nontransforming P3HR-1 virus had no cytotoxic effect on mouse lymphocytes. The EBV-infected, stimulated mouse lymphocytes did not express EB virus-determined nuclear antigen and do not grow into immortalized cell lines. The cells expressed EBV-determined early and virus capsid antigens. These results suggest that the stimulation of cellular DNA synthesis by EBV is independent of EBNA synthesis and cell transformation.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology / Q000382:microbiology; D002472:Cell Transformation, Viral; D004261:DNA Replication; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D007700:Kinetics; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000382:microbiology*; D051379:Mice
D000956:Antigens, Viral