The deinhibitor protein: regulation by phosphorylation-dephosphorylation.
The deinhibitor protein, which protects the multisubstrate protein phosphatase from inhibition by inhibitor-1 and the modulator protein, stabilizes the enzyme in its active conformation preventing its conversion to the ATP,Mg-dependent enzyme form and controls the dephosphorylation of inhibitor-1, was shown to exist under active and inactive forms. It can be inactivated by the catalytic unit of the cyclic AMP-dependent protein kinase and reactivated by an inhibitor-1 phosphatase, also described as histone-H1 ("latent") stimulated protein phosphatase.
D000818:Animals; D002352:Carrier Proteins; D002417:Cattle; D000242:Cyclic AMP / Q000494:pharmacology; D047908:Intracellular Signaling Peptides and Proteins; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000201:enzymology; D010765:Phosphorylase Phosphatase / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000494:pharmacology; D011506:Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; C033035:deinhibitor protein, Canis familiaris; C021042:protein phosphatase inhibitor-1; D000242:Cyclic AMP; D011494:Protein Kinases; D010765:Phosphorylase Phosphatase