title: A rise in cyclic AMP with a lack of glycogenolysis by secretin in the isolated perfused rat liver and its inhibition by epinephrine.
abstract: The effects of secretin on glucose output and cyclic AMP from the isolated perfused rat liver were investigated. Secretin 0.1 U/ml increased cyclic AMP in the effluent without an increase in glucose output. Glucose output induced by epinephrine 10(-8)M was not affected by secretin 0.1 U/ml administered simultaneously, whereas the increase in cyclic AMP produced by secretin 0.1 U/ml was inhibited by epinephrine 10(-8)M. The increase in cyclic AMP produced by glucagon 10(-10)M was not affected by epinephrine 10(-8)M. These results suggest that secretin does not affect glycogenolysis in the liver and secretin activates adenylate cyclase through a different receptor from glucagon in the liver.
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008112:Liver Glycogen / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D012633:Secretin / Q000494:pharmacology*
chemical_list: D008112:Liver Glycogen; D012633:Secretin; D000242:Cyclic AMP; D005947:Glucose; D004837:Epinephrine