Antiviral response of fibroblasts from familial Alzheimer's disease and Down's syndrome to human interferon-alpha.
The relative sensitivities of human fibroblast cultures from patients with familial Alzheimer's disease (AD), patients with Down's syndrome (Trisomy 21, T-21), and normal control (D-21) subjects, to the antiviral effect of human interferon-alpha (Hu-IFN-alpha) were compared. In confirmation of previous studies, T-21 cell lines showed significantly enhanced sensitivities to IFN compared with D-21 cells from normal controls. Fibroblast cultures from 2 familial AD patients belonging to one family exhibited sensitivities which fell within the range of response of normal D-21 cells. In contrast, fibroblasts from two other related subjects, one with familial AD and his niece "at risk", were extremely insensitive to interferon.
D000544:Alzheimer Disease / Q000235:genetics / Q000382:microbiology*; D002460:Cell Line; D004314:Down Syndrome / Q000382:microbiology*; D005347:Fibroblasts; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus; D014777:Virus Diseases / Q000517:prevention & control
D007370:Interferon Type I