title: Effect of chloroquine and O,O'-bis(diethylaminoethyl)hexestrol on acidic phospholipid membranes.
abstract: The amphiphilic drugs chloroquine and O,O'-bis(diethylaminoethyl)hexestrol are able to form complexes with the acidic-phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol. The dissociation constants of the complexes with chloroquine are independent of pH in the range investigated here (4--7) as well as of temperature (4 degrees C--40 degrees C). The phase transition temperature of phospholipid is markedly reduced by both drugs, the effect is reversible by addition of Ca2.
mesh_terms: D002118:Calcium; D055598:Chemical Phenomena; D002621:Chemistry; D002738:Chloroquine; D006589:Hexestrol / Q000031:analogs & derivatives; D006863:Hydrogen-Ion Concentration; D008081:Liposomes; D010715:Phosphatidylglycerols; D011663:Pulmonary Surfactants; D013696:Temperature
chemical_list: D008081:Liposomes; D010715:Phosphatidylglycerols; D011663:Pulmonary Surfactants; D006589:Hexestrol; D002738:Chloroquine; D002118:Calcium; C100116:hexestrol bis(diethylaminoethyl ether)