title: Generation of leukotrienes from human granulocytes by alveolysin from Bacillus alvei.
abstract: We investigated the effect of alveolysin on human granulocytes. Alveolysin is an exoprotein produced by Bacillus alvei and belongs to the group of sulfhydryl-activated cytolysins. Other members of this group are streptolysin O and theta-toxin from Clostridium perfringens. It is demonstrated that alveolysin leads to leukotriene generation from human granulocytes, which exert chemotactic (leukotriene B4) and slow-reacting substance (leukotriene C4, D4, and E4) activity under sublytic concentrations.
mesh_terms: D000818:Animals; D001407:Bacillus / Q000032:analysis*; D002634:Chemotaxis, Leukocyte; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D006098:Granulocytes / Q000378:metabolism*; D006168:Guinea Pigs; D006460:Hemolysin Proteins / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D007975:Leukotriene B4 / Q000096:biosynthesis*; D017999:Leukotriene E4; D009930:Organic Chemicals; D013189:SRS-A / Q000031:analogs & derivatives* / Q000096:biosynthesis*
chemical_list: D006460:Hemolysin Proteins; D009930:Organic Chemicals; D013189:SRS-A; D007975:Leukotriene B4; D017999:Leukotriene E4; C014963:alveolysin