Neurotoxicity of kainic acid: evidence against an interaction with excitatory glutamate receptors in rat olfactory bulbs.
The hypothetical interaction of kainic acid (KA) at excitatory glutamate (GLU) receptors was tested by injecting this neurotoxin into the olfactory bulb (OB), since the putatively GLUergic output neurons of the OB are among the few neurons in the CNS that are not excited by GLU. However, the mitral (and tufted) cells are found to be highly and preferentially destroyed by KA, whereas the GLUreceptive interneurons of the OB appear to be relatively resistant to the neurotoxin. These findings suggest that the toxic effect of KA on OB neurons may be mediated by mechanisms other than by action on GLUreceptors.
D000818:Animals; D007395:Interneurons / Q000187:drug effects; D007608:Kainic Acid / Q000494:pharmacology*; D009830:Olfactory Bulb / Q000187:drug effects*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects*; D017470:Receptors, Glutamate
D011759:Pyrrolidines; D011956:Receptors, Cell Surface; D017470:Receptors, Glutamate; D007608:Kainic Acid