Transient neonatal hypothyroidism due to maternal immunoglobulins that inhibit thyrotropin-binding and post-receptor processes.
Transient neonatal hypothyroidism was found in a daughter of a 25-yr-old mother, who was receiving treatment for primary hypothyroidism due to Hashimoto's thyroiditis. During the neonatal period the infant had antithyroid microsomal and antithyroglobulin antibodies and TSH-receptor antibodies. The daughter recovered spontaneously from the hypothyroid state and the antithyroid antibodies disappeared from her serum. The mother's serum contained the same antibodies, and immunoglobulin G (IgG) from maternal serum blocked TSH binding to its receptors, TSH-stimulated cAMP responses, and cAMP-stimulated iodine uptake and organification in cultured thyroid cells. The latter finding suggests that the IgG had a postreceptor locus of action as well as inhibiting TSH binding to its receptor. The presence of such IgGs might have induced hypothyroidism both in the mother and in the daughter.
D000328:Adult; D001323:Autoantibodies / Q000502:physiology; D003994:Bucladesine / Q000494:pharmacology; D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000502:physiology*; D007231:Infant, Newborn; D007455:Iodine / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D011989:Receptors, Thyrotropin; D013972:Thyrotropin / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology / Q000502:physiology
D001323:Autoantibodies; D007074:Immunoglobulin G; D011956:Receptors, Cell Surface; D011989:Receptors, Thyrotropin; D003994:Bucladesine; D013972:Thyrotropin; D007455:Iodine; D000242:Cyclic AMP