Effects of chrysotile co-exposure on BaP binding in normal human fibroblasts.
The effects of chrysotile and benzo(a)pyrene (BaP) co-exposure on uptake, metabolism and BaP binding to nucleic acids were investigated in normal human fibroblasts. A significant enhancement in these parameters was found when co-exposure was carried out under serum-free conditions. In the presence of serum, only a slight enhancement of BaP uptake was detected, while metabolism and binding to nucleic acids were not affected over the 8-hr incubation period studied.
D001194:Asbestos / Q000633:toxicity*; D017632:Asbestos, Serpentine; D001564:Benzo(a)pyrene; D001580:Benzopyrenes / Q000378:metabolism*; D002478:Cells, Cultured; D003470:Culture Media; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D009696:Nucleic Acids / Q000378:metabolism
D017632:Asbestos, Serpentine; D001580:Benzopyrenes; D003470:Culture Media; D009696:Nucleic Acids; D001194:Asbestos; D001564:Benzo(a)pyrene