The effects of sulfated and nonsulfated cholecystokinin octapeptides on electroconvulsive shock-induced retrograde amnesia after intracerebroventricular administration in rats.
The effects of several doses of intracerebroventricularly injected cholecystokinin octapeptide sulfate ester (CCK-8-SE) and nonsulfated scholecystokinin octapeptide (CCK-8-NS) were studied on electroconvulsive shock (ECS)-induced retrograde amnesia, as measured in a one-trial step-through passive avoidance paradigm. Both CCK-8-SE and CCK-8-NS were able to attenuate amnesia slightly when they were injected into rats 10 min prior to ECS treatment, possibly by reducing the severity of the ECS-induced seizures. Of the treatments carried out immediately after ECS, only the 0.8 pmole dose of CCK-8-NS could significantly restore retrograde amnesia. After treatment 20 min prior to testing 24-hr retention, no effect of the peptides was observed. The lack of a dose-dependency and of any effect on retrieval raises the possibility that the CCK octapeptides influence memory processes by an indirect mechanism.
D000647:Amnesia / Q000503:physiopathology*; D000648:Amnesia, Retrograde / Q000503:physiopathology*; D000818:Animals; D004597:Electroshock; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013431:Sulfates
D013431:Sulfates; D012844:Sincalide