Inappropriate correction for radioactive decay in fully iodinated adrenergic radioligands.
The present data demonstrate increased binding of various iodinated adrenergic radioligands. In contrast, this was not observed for [3H]dihydroalprenolol. This systematic deviation of apparent binding parameters can be explained by the inappropriate use of a decay correction factor, indicating that the decayed iodinated radioligands lose their binding ability. Consequently no correction for decay is required in the case of iodinated adrenergic radioligands.
D000818:Animals; D001001:Anura; D004912:Erythrocytes / Q000378:metabolism; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D011869:Radioligand Assay / Q000379:methods*; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D014316:Tritium
D007457:Iodine Radioisotopes; D011943:Receptors, Adrenergic, beta; D014316:Tritium