Effects of acetate and bicarbonate hemodialysis on cardiac function in chronic dialysis patients.
Previous studies have suggested that acetate hemodialysis causes myocardial depression. This study examines the acute effects of hemodialysis using, alternately, bicarbonate and acetate in the dialysate, on cardiac function in ten patients. These patients were also studied during acetate dialysis using a large surface area (SA) dialyzer. Each patient was dialyzed for 4 hr with: (1) 1.0 m2 SA dialyzer and bicarbonate dialysate; (2) 1.0 m2 SA dialyzer and acetate bath, and; (3) 2.5 m2 SA dialyzer and acetate dialysate. All studies were performed during isovolemic dialysis to separate the effects of changes in cardiac filling volume with hemodialysis, from changes in myocardial contractility. Myocardial function, as assessed by pre- and postdialysis echocardiographically derived fractional shortening (Fs) and mean velocity of circumferential shortening (VCF), improved (P less than 0.05) to the same extent, after all three dialysis treatments. This occurred despite greater increases (P less than 0.002) in pH and bicarbonate after bicarbonate dialysis and decreases (P less than 0.05) in PO2, PCO2 and bicarbonate after acetate dialysis with 2.5 m2 SA dialyzer. These results indicate that diffusive dialysis with both acetate and bicarbonate dialysate improves myocardial function and do not support the view that acetate influx during dialysis can lead to myocardial depression.
D000085:Acetates / Q000494:pharmacology*; D019342:Acetic Acid; D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000494:pharmacology*; D002306:Cardiac Volume / Q000187:drug effects; D003864:Depression, Chemical; D004452:Echocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007688:Kidneys, Artificial; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D006435:Renal Dialysis; D017693:Sodium Bicarbonate; D013268:Stimulation, Chemical; D013318:Stroke Volume / Q000187:drug effects
D000085:Acetates; D001639:Bicarbonates; D017693:Sodium Bicarbonate; D019342:Acetic Acid