Chronic lymphocytic leukemia with IgM lambda and IgG lambda cytoplasmic inclusions.
We studied a unique case of chronic lymphocytic leukemia with intracytoplasmic inclusions containing IgM lambda and IgG lambda. We postulated a neoplastic arrest in B-cell ontogeny at the point of the IgM-IgG switch and a secretory defect.
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D002479:Inclusion Bodies / Q000276:immunology* / Q000648:ultrastructure; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains