Lithium, sodium and potassium transport in erythrocytes of manic-depressive patients.
Different Li, Na and K transport pathways were assessed in erythrocytes from manic-depressive patients. No alteration in the Li-Na countertransport, Na,K cotransport or passive permeabilities was observed in either unipolar or bipolar manic-depressive patients. In addition, acute or chronic lithium treatment did not alter the maximal velocity of either the Li-Na countertransport or the Na,K cotransport. A two-fold reduction of the ouabain-sensitive Na efflux was observed among manic-depressive patients without alteration in the affinity of the Na pump for internal Na.
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D007700:Kinetics; D008094:Lithium / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*
D007473:Ion Channels; D008094:Lithium; D012964:Sodium; D011188:Potassium