Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation.
The sensitivity to regulation of proteins undergoing covalent modification can be greatly increased when the substrates saturate the converter enzymes. This phenomenon, termed zero-order ultrasensitivity, has been found to occur in the reversible phosphorylation of isocitrate dehydrogenase. The possibility that this enhanced sensitivity is a common feature of covalent regulatory systems is discussed.
D000494:Allosteric Regulation; D004789:Enzyme Activation; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D007700:Kinetics; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism
D010750:Phosphoproteins; D007521:Isocitrate Dehydrogenase; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases