Studies on concanavalin A receptor sites of tumour cells following ultraviolet exposure.
Alteration of surface receptor of Ehrlich tumour cells by concanavalin A (Con A), shortwave UV and UV plus Con A have been studied. DNA of nuclear chromatins is highly sensitive to UV but receptor glycoprotein sites are UV resistant as evidenced by their retention of agglutination properties after radiation. Con A and UV plus Con A treatments of tumour cells delay the in vivo growth of solid tumour which may be due to some immunological mechanism.
D000372:Agglutination Tests; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D003131:Combined Modality Therapy; D003208:Concanavalin A / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000528:radiation effects*; D014467:Ultraviolet Therapy
D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; C032193:glycoprotein receptor GPIb-IX; D003208:Concanavalin A