Enhancement of adipose S-100 protein release by catecholamines.
When rat epididymal fat-pad pieces were incubated in vitro with 10 microM epinephrine, S-100 protein in the tissue was markedly decreased by release into the medium. The release of adipose S-100 protein was also enhanced by norepinephrine (10 microM), isoproterenol (10 microM), and dibutyryl cyclic AMP (5 mM), but not by insulin (0.8 microM). The enhancement of S-100 protein release by 10 microM epinephrine was completely inhibited by 10 microM propranolol. These results suggest that the release of adipose S-100 protein is regulated by the beta-adrenergic effect of catecholamines.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D009418:S100 Proteins / Q000378:metabolism*; D013565:Sympatholytics / Q000494:pharmacology
D002395:Catecholamines; D007328:Insulin; D009418:S100 Proteins; D013565:Sympatholytics; D003994:Bucladesine