Analysis of radioimmunodetection of tumors by the subtraction technique.
The subtraction method for radioimmunodetection (RID) of cancer is showing potential as a diagnostic tool. An objective assessment of this technique is needed in order to determine its clinical usefulness. A numerical analysis of the RID scintigrams was developed and applied to 21 RID studies on 20 patients for whom a final diagnosis had been established. The subtraction technique was shown to give rise to artifactual positive regions, which could be avoided by experienced clinicians. When artifact-producing regions were excluded, 97 regions were examined (80 nontumor, 17 tumor-containing). The "background" scintigrams were shown to be good models for nontumor regions of the antibody scintigrams, and tumor and nontumor regions were shown to form statistically distinct groups.
D000906:Antibodies; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D006801:Humans; D007457:Iodine Radioisotopes; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D011877:Radionuclide Imaging; D012709:Serum Albumin; D013670:Sodium Pertechnetate Tc 99m; D013223:Statistics as Topic; D013382:Subtraction Technique; D013667:Technetium; D013668:Technetium Tc 99m Aggregated Albumin
D000906:Antibodies; D002272:Carcinoembryonic Antigen; D007457:Iodine Radioisotopes; D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m