Modulation of synapse formation by cyclic adenosine monophosphate.
Synapses between neuroblastoma-hybrid cells and myotubes exhibit a high degree of plasticity. Increase of cyclic adenosine monophosphate (AMP) levels of the hybrid cells for several days results in the appearance of functional voltage-sensitive Ca2+ channels, which are required for evoked secretion of acetylcholine. The results show that cyclic AMP regulates synaptogenesis by regulating the expression of voltage-sensitive Ca2+ channels, and suggest that cyclic AMP affects posttranslational modifications of some glycoproteins and cellular levels of certain proteins.
D000818:Animals; D000911:Antibodies, Monoclonal; D002118:Calcium / Q000502:physiology; D002448:Cell Adhesion; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D008564:Membrane Potentials; D009419:Nerve Tissue Proteins / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D009473:Neuronal Plasticity; D011956:Receptors, Cell Surface / Q000502:physiology; D012160:Retina / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D000911:Antibodies, Monoclonal; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D000242:Cyclic AMP; D002118:Calcium