Some theoretical questions of mechanisms of thyroid hormone action.
The effects of iodothyronines, the suggested mechanisms of their action, the methodical difficulties of determining receptors of thyroid hormones, the significance of iodothyronine formation during hormone action and some stereochemical aspects of the receptor--thyroid hormone interaction have been reviewed and a new model of the thyroid hormone action has been developed. It is suggested that the thyroid hormones may interact with more than one protein and nucleic acid at the same time and in this way "help" the interaction of macromolecules, thus catalysing and modulating biochemical processes of diverse character.
D006801:Humans; D007467:Iodoproteins / Q000378:metabolism; D008954:Models, Biological; D008968:Molecular Conformation; D009504:Neutrophils / Q000378:metabolism; D009696:Nucleic Acids / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000032:analysis*; D011988:Receptors, Thyroid Hormone; D013954:Thyroglobulin / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D013970:Thyronines / Q000378:metabolism / Q000494:pharmacology; D013974:Thyroxine / Q000378:metabolism
D007467:Iodoproteins; D009696:Nucleic Acids; D011956:Receptors, Cell Surface; D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones; D013970:Thyronines; C013068:3-monoiodothyronine; D013954:Thyroglobulin; D013974:Thyroxine