Histological and histochemical observations on the testis and epididymis of the albino rat treated with ACTH 1-39 and dexamethasone.
We analysed the modifications induced in the testis and epididymis of the adult male albino rat by drugs stimulating (ACTH) and inhibiting (dexamethasone) the steroidogenesis of the adrenal cortex. After stopping treatment, observations were continued for several days in order to follow up the possible long-term effects of these drugs. Morphological examination showed that the greatest damage in the testis was produced a few days after suspension of treatment by small doses of ACTH and that, with dexamethasone, the testis and epididymis were damaged, especially after discontinuing treatment. No noteworthy histochemical modifications were observed.
D000324:Adrenocorticotropic Hormone / Q000633:toxicity*; D000818:Animals; D003907:Dexamethasone / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects; D006651:Histocytochemistry; D008055:Lipids / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000032:analysis / Q000187:drug effects* / Q000473:pathology
D008055:Lipids; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone