title: Ca2+, Mg2+ and (adenosine diphosphate ribose)n in cellular response to irradiation.
abstract: A model of cellular response to irradiation involving adenosine diphosphate ribosylation (ADP-ribosylation) is proposed. Its main assumptions are (a) control of accessibility of sites for ADP-ribosylation in chromatin by free Ca2+/Mg2+ ratio; and (b) regulation of the Ca2+/Mg2+ ratio by factors affecting intracellular free Ca2+ concentration; the regulation would be mediated by mitochondria. The model seeks to explain the mechanism of action of radiomodifiers such as caffeine, local anaesthetics, polyamines and 2,4-dinitrophenol.
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology; D004261:DNA Replication; D004140:Dinitrophenols / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D008274:Magnesium / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009243:NAD / Q000378:metabolism; D009702:Nucleoside Diphosphate Sugars / Q000378:metabolism*; D010100:Oxygen; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011073:Polyamines / Q000494:pharmacology; D011836:Radiation Tolerance
chemical_list: D002843:Chromatin; D004140:Dinitrophenols; D009702:Nucleoside Diphosphate Sugars; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011073:Polyamines; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D002110:Caffeine; D000242:Cyclic AMP; D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase; D008274:Magnesium; D010100:Oxygen; D002118:Calcium