[Increase by somatocrinin of a cyclic AMP-dependent protein kinase activity in adenohypophyseal, secretory granules in the hog].
This study shows that the growth hormone hypothalamic releasing factor (somatocrinin) stimulates the activity of cyclic AMP-dependent protein kinase associated with a purified fraction of hog anterior pituitary secretory granules. Threshold, half-maximal and maximal concentrations (0.3, 35 pM and 10 nM, respectively, in the presence of 50 nM cyclic AMP) are similar to those observed for in vitro stimulation of growth hormone release by somatocrinin.
D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000201:enzymology*; D004789:Enzyme Activation; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D007700:Kinetics; D010903:Pituitary Gland, Anterior / Q000201:enzymology*; D011494:Protein Kinases / Q000378:metabolism*; D013552:Swine
D013007:Growth Hormone-Releasing Hormone; D000242:Cyclic AMP; D011494:Protein Kinases
Augmentation par la somatocrinine de l'activité d'une protéine-kinase AMP cyclique-dépendante sur les granules sécrétoires adénohypophysaires de porc.