The effect of bradykinin, histamine, and leukotrienes B4, C4 and D4 on the formation of 6-keto-prostaglandin F1 alpha and thromboxane B2 in hamster lungs.
Bradykinin, histamine, leukotriene B4, C4, D4 (LTB4, LTC4, LTD4), and bradykinin + LTC4 were injected as a bolus into the pulmonary circulation of hamster isolated lungs, and the amounts of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TXB2) in the perfusion effluent were determined by radioimmunoassay. LTD4, bradykinin, and bradykinin + LTC4 stimulated 6-keto-PGF1 alpha formation whereas TXB2 formation was stimulated only by LTB4 and histamine. The detected changes in the activation of arachidonate metabolism were, however, relatively small. The present study indicates that bradykinin, histamine, LTB4, and LTD4 have only a minor stimulating effect on arachidonic acid metabolism in hamster lungs.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001920:Bradykinin / Q000494:pharmacology*; D006224:Cricetinae; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D013189:SRS-A / Q000494:pharmacology; D013929:Thromboxane B2 / Q000096:biosynthesis
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D013189:SRS-A; D007975:Leukotriene B4; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D006632:Histamine; D001920:Bradykinin