Isolation and characterization of the mouse corticotropin-beta-lipotropin precursor gene and a related pseudogene.
Two mouse genomic DNA sequences homologous with human corticotropin-beta-lipotropin precursor gene sequences have been cloned. One of them represents the functional corticotropin-beta-lipotropin precursor gene, which exhibits a structural organization similar to those of its bovine and human counterparts. The other represents a pseudogene that corresponds to the functional mouse gene sequence encoding the carboxy-terminal 143 amino acid residues (including corticotropin and beta-lipotropin) and the 3'-untranslated region.
D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D002417:Cattle; D004247:DNA / Q000302:isolation & purification*; D004262:DNA Restriction Enzymes; D004274:DNA, Recombinant / Q000302:isolation & purification; D006801:Humans; D051379:Mice; D009693:Nucleic Acid Hybridization; D010908:Pituitary Hormones, Anterior / Q000235:genetics*; D011333:Pro-Opiomelanocortin; D011498:Protein Precursors / Q000235:genetics*
D004274:DNA, Recombinant; D010908:Pituitary Hormones, Anterior; D011498:Protein Precursors; D011333:Pro-Opiomelanocortin; D004247:DNA; D004262:DNA Restriction Enzymes