title: Retzius cells retain functional membrane properties following 'ablation' by the neurotoxin 5,7-DHT.
abstract: The neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) is generally believed to selectively ablate serotonergic neurons. Serotonin-containing Retzius cells (RZ) in the leech appear ablated by 5,7-DHT treatment. However, these brown, mis shapen , non-fluorescent neurons retain their synaptic inputs, action potentials, electronic outputs, a membrane receptor, and axonal projections.
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D005724:Ganglia / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D007865:Leeches / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D004102:Dihydroxytryptamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin