title: Indomethacin and sulindac inhibition of ACTH stimulated cortisol release from adrenal glands in vitro.
abstract: In slices of adrenal glands of guinea pig added ACTH (from femtograms to picograms levels) stimulates cortisol synthesis and release. This effect is antagonized in a non-linear competitive way by indomethacin (KE = 1.3 .10(-7)) and by sulindac (KI = 6.9 .10(-10)); indoprofen is a very weak antagonist. A number of other non-steroid antiinflammatory drug are ineffective as antagonists of ACTH.
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000378:metabolism*; D066298:In Vitro Techniques; D007192:Indenes / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D013467:Sulindac / Q000494:pharmacology*
chemical_list: D007192:Indenes; D013467:Sulindac; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D007213:Indomethacin