CRF-41 stimulates the release of beta-lipotrophin and beta-endorphin in normal human subjects.
A prompt rise in circulating immunoreactive N- and C-terminal lipotrophin (LPH) accompanied the increase in ACTH when 100 micrograms CRF-41 was given to 6 normal male subjects. Chromatography of the basal and peak 15-min values showed that there was an equimolar increase in beta-LPH and beta-endorphin, to cause parallel release of ACTH, beta-endorphin and beta-LPH from the pro-opiocortin precursor.
D000328:Adult; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004723:Endorphins / Q000097:blood*; D006801:Humans; D008297:Male; D013268:Stimulation, Chemical; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000097:blood*
D004723:Endorphins; D001615:beta-Endorphin; D003346:Corticotropin-Releasing Hormone; D008083:beta-Lipotropin