[Pharmacokinetic profile of a slow-release ketoprofen preparation].
Kinetics of ketoprofen release in man from a sustained-release preparation (150 mg) and from capsules (3 X 50 mg) were studied comparatively in 10 healthy adults. Bioavailability of the slow-release preparation is similar to that of capsules : surfaces under the serum concentration curves and urinary elimination were found to be identical. In the sustained-release preparation the immediately available layer (75 mg) ensures achievement of maximal serum concentrations amounting to 59% of those obtained with capsules, after the same time interval. The slow-release layer (75 mg) produces higher serum concentrations from the third hour on, justifying administration of the formulation in two daily doses.
D002214:Capsules; D003692:Delayed-Action Preparations; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010666:Phenylpropionates / Q000378:metabolism*; D013607:Tablets
D002214:Capsules; D003692:Delayed-Action Preparations; D010666:Phenylpropionates; D013607:Tablets; D007660:Ketoprofen
Profil pharmacocinétique d'une formulation à libération prolongée de kétoprofène.