Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.
A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked to a particular hypervariable region between the zeta 2 and zeta 1 genes. This suggests that these hypervariable regions are stable and will be useful for genetic analysis.
D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D003535:Cyprus; D004247:DNA / Q000032:analysis / Q000235:genetics*; D004262:DNA Restriction Enzymes; D015252:Deoxyribonucleases, Type II Site-Specific; D005796:Genes; D005914:Globins / Q000235:genetics*; D006115:Greece; D006720:Homozygote; D006801:Humans; D007558:Italy; D011110:Polymorphism, Genetic
D005914:Globins; D004247:DNA; D004262:DNA Restriction Enzymes; D015252:Deoxyribonucleases, Type II Site-Specific; C018492:GCCNNNNNGGC-specific type II deoxyribonucleases