Ontogenesis of autonomic receptors in detrusor muscle and bladder sphincter of human fetus.
An investigation was made of the distribution and the ontogenesis of various types of receptors in the bladder detrusor muscles and sphincter isolated from human fetuses at different stages of pregnancy. Cholinergic receptors appear very early in the fetal urinary bladder since contractile responses to bethanechol, competitively blocked by atropine, are observed in detrusor muscle preparations at three months and in the sphincter at four months. Later on, the density of cholinergic receptors increases in the detrusor muscle whereas there is a progressive reduction in the sphincter.
D005260:Female; D005333:Fetus / Q000502:physiology*; D006128:Growth; D006801:Humans; D011247:Pregnancy; D011941:Receptors, Adrenergic / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000502:physiology; D011968:Receptors, Histamine / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology; D001743:Urinary Bladder / Q000196:embryology* / Q000294:innervation
D011941:Receptors, Adrenergic; D011956:Receptors, Cell Surface; D011950:Receptors, Cholinergic; D011968:Receptors, Histamine; D011985:Receptors, Serotonin