Angiotensin stimulates beta-endorphin release from anterior pituitary gland cell cultures of rats.
The effect of exogenous and locally generated angiotensin II (ANG II) on the release of beta-endorphin (beta-END) from anterior pituitary cell cultures of rats was studied. Angiotensin I (ANG I) and ANG II stimulated the release of beta-END, the ANG I effects being inhibited by addition of the converting enzyme inhibitor captopril. Renin and angiotensinogen had no effect when given separately, but their combination increased beta-END release. Thus ANG II causes the release of beta-END, but the putative pituitary renin system cannot be stimulated by exogenous renin or angiotensinogen; converting enzyme, however, acts locally to produce biologically active ANG II from ANG I.
D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000808:Angiotensinogen / Q000494:pharmacology; D000809:Angiotensins / Q000494:pharmacology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D002478:Cells, Cultured; D004347:Drug Interactions; D004723:Endorphins / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000494:pharmacology; D001615:beta-Endorphin
D000809:Angiotensins; D004723:Endorphins; D000808:Angiotensinogen; D000804:Angiotensin II; D001615:beta-Endorphin; D000803:Angiotensin I; D002216:Captopril; D012083:Renin