Squamous metaplasia of tracheal submucosal glands induced by benzo[a]pyrene and vitamin A deficiency.
The effects on tracheal glands of benzo[a]pyrene and of vitamin A deficiency were examined in explants derived from normal and vitamin A deficient hamsters, respectively. Both treatments caused hyperplasia and squamous metaplasia of the tracheal glands. It is suggested that a proportion of respiratory tract lesions may originate in tracheal glands.
D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes; D006224:Cricetinae; D004848:Epithelium / Q000473:pathology; D008647:Mesocricetus; D008679:Metaplasia / Q000209:etiology; D009924:Organ Culture Techniques; D014132:Trachea / Q000473:pathology*; D014802:Vitamin A Deficiency / Q000150:complications*
D001580:Benzopyrenes; D001564:Benzo(a)pyrene