[Determination of in vivo and in vitro toxin activity. I. A new method of determining in vitro activity].
The potency of 5 toxins of different microbial species has been studied by common in vivo methods and by the in vitro method based on measuring the relative test-microbe growth inhibiting units 50. The possibility of using this method for the determination of toxicity in vitro with a view of studying the potency of diphtheria and gas-gangrene exotoxins, as well as that of Pseudomonas aeruginosa exotoxin, is substantiated.
D000818:Animals; D001431:Bacteriological Techniques; D003016:Clostridium perfringens; D003353:Corynebacterium diphtheriae; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D005098:Exotoxins / Q000633:toxicity*; D066298:In Vitro Techniques; D051379:Mice; D011550:Pseudomonas aeruginosa
D005098:Exotoxins
Opredelenie aktivnosti toksinov in vivo i in vitro. Soobshchenie I. Novyĭ metod opredeleniia aktivnosti in vitro.