title: Ranitidine does not affect chlormethiazole or indocyanine green disposition.
abstract: Cimetidine has been shown to inhibit hepatic mixed-function oxidase activity and to lower hepatic blood flow. It is not known whether these effects are related to its H2-receptor antagonism or to its intrinsic structure. Ranitidine is a more potent H2-receptor antagonist and differs structurally from cimetidine. In our study, ranitidine, 150 mg twice daily, had no effect on oral or systemic clearance of chlormethiazole, a sedative with a high clearance, and no effect on indocyanine green elimination.
mesh_terms: D000328:Adult; D002719:Chlormethiazole / Q000097:blood*; D004347:Drug Interactions; D005260:Female; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D007208:Indocyanine Green / Q000097:blood*; D008099:Liver / Q000098:blood supply; D008297:Male; D011899:Ranitidine
chemical_list: D005663:Furans; D002719:Chlormethiazole; D011899:Ranitidine; D007208:Indocyanine Green