Early infections in kidney, heart, and liver transplant recipients on cyclosporine.
Eighty-one renal, seventeen heart, and twenty-four liver transplant patients were followed for infection. Seventeen renal patients received azathioprine (Aza) and prednisone as part of a randomized trial of immunosuppression with 21 cyclosporine-and-prednisone-treated renal transplant patients. All others received cyclosporine and prednisone. The randomized Aza patients had more overall infections (P less than 0.05) and more nonviral infections (P less than 0.02) than the randomized cyclosporine patients. Heart and liver patients had more infections than cyclosporine renal patients but fewer infections than the Aza renal patients. There were no infectious deaths in renal transplant patients on cyclosporine or Aza, but infection played a major role in 3 out of 6 cardiac transplant deaths and in 8 out of 9 liver transplant deaths. Renal patients on cyclosporine had the fewest bacteremias. Analysis of site of infection showed a preponderance of abdominal infections in liver patients, intrathoracic infections in heart patients, and urinary tract infections in renal patients. Pulmonary infections were less common in cyclosporine-treated renal patients than in Aza-treated patients (P less than 0.05). Aza patients had significantly more staphylococcal infections than all other transplant groups (P less than 0.005), and systemic fungal infections occurred only in the liver transplant group. Cytomegalovirus (CMV) shedding or serological rises in antibody titer, or both occurred in 78% of cyclosporine patients and 76% of Aza patients. Of the cyclosporine patients, 15% had symptoms related to CMV infection. Serological evidence for Epstein Barr Virus infection was found in 20% of 65 cyclosporine patients studied. Three had associated symptoms, and one developed a lymphoma.
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D003524:Cyclosporins / Q000008:administration & dosage* / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation; D006561:Herpes Simplex / Q000150:complications; D006801:Humans; D007239:Infections / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008171:Lung Diseases / Q000209:etiology; D008297:Male; D009181:Mycoses / Q000150:complications; D010414:Pennsylvania; D011241:Prednisone / Q000008:administration & dosage; D018805:Sepsis / Q000209:etiology; D012871:Skin Diseases / Q000209:etiology; D013203:Staphylococcal Infections / Q000150:complications
D003524:Cyclosporins; D001379:Azathioprine; D011241:Prednisone