Amphiphilic secondary structure: design of peptide hormones.
Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.
D000595:Amino Acid Sequence; D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001665:Binding Sites; D002116:Calcitonin; D055598:Chemical Phenomena; D002621:Chemistry; D003346:Corticotropin-Releasing Hormone; D004723:Endorphins; D005934:Glucagon; D013007:Growth Hormone-Releasing Hormone; D006728:Hormones / Q000494:pharmacology; D008075:Lipoproteins, HDL; D008555:Melitten; D008961:Models, Structural; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D001615:beta-Endorphin
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D004723:Endorphins; D006728:Hormones; D008075:Lipoproteins, HDL; D010455:Peptides; D008555:Melitten; D001615:beta-Endorphin; D002116:Calcitonin; D005934:Glucagon; D003346:Corticotropin-Releasing Hormone; D013007:Growth Hormone-Releasing Hormone