Polyoma middle T antigen requires cooperation from another gene to express the malignant phenotype in vivo.
The oncogenic potential of polyomavirus in newborn hamsters can be expressed by a recombinant encoding only the middle T protein. However, polyoma middle T requires the cooperation from small T to induce tumors in newborn rats. Similar complementary functions such as cocarcinogens or tumor promotors can be exerted by the simian virus 40 T antigens as well as by one or several products of the early region 1A of adenovirus 2.
D000260:Adenoviruses, Human / Q000235:genetics; D000818:Animals; D000831:Animals, Newborn; D000957:Antigens, Viral, Tumor / Q000235:genetics*; D002472:Cell Transformation, Viral; D006224:Cricetinae; D005814:Genes, Viral; D010641:Phenotype; D011120:Polyomavirus / Q000235:genetics* / Q000276:immunology; D051381:Rats; D013539:Simian virus 40 / Q000235:genetics; D013045:Species Specificity
D000957:Antigens, Viral, Tumor