Effect of cobalt on electrical and mechanical responses to exogenous noradrenaline and to field stimulations in the guinea-pig vas deferens.
Co2+ suppressed the mechanical responses evoked by field stimulations and by application of noradrenaline (NA) in the smooth muscle of guinea-pig vas deferens. However, the membrane excitation and force development evoked by depolarizing currents were not much affected in the Co2+ treatment. It is proposed that Co2+ suppresses NA induced contraction by inhibiting the development of the membrane depolarization.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D014649:Vas Deferens / Q000187:drug effects*
D011942:Receptors, Adrenergic, alpha; D003035:Cobalt; D009638:Norepinephrine