Effect of endotoxin on mouse serum angiotensin-converting enzyme.
The effect of endotoxin on serum levels of angiotensin-converting enzyme (ACE) in mice was studied. At a dose of 0.5 mg/kg intraperitoneally administered, endotoxin from Escherichia coli and Serratia marcescens lowered serum ACE. The effect of E. coli endotoxin on serum ACE can be demonstrated by 2 h, it returns to control values in 24 h, and is not dose-dependent in the 0.5 to 8.0 mg/kg range. The reduction of mouse serum ACE by parenteral endotoxin mimics the lower serum ACE observed in patients with gram-negative sepsis.
D000818:Animals; D001424:Bacterial Infections / Q000097:blood / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D007703:Peptidyl-Dipeptidase A / Q000097:blood*; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000201:enzymology; D012706:Serratia marcescens
D004731:Endotoxins; D007703:Peptidyl-Dipeptidase A