Adrenocorticotropin. 57. Synthesis and biological activity of ostrich and turkey hormones.
Synthesis of ostrich and turkey corticotropin (ACTH) has been accomplished by the solid-phase method. Each was identical to the natural hormone in high performance liquid chromatography. Relative potencies in a lipolytic assay in isolated rabbit fat cells were: human ACTH, 100; ostrich ACTH, 53; turkey ACTH, 28. In isolated rat fat cells relative lipolytic potencies were: human ACTH, 100; ostrich ACTH, 2; turkey ACTH, 13. It was concluded that lipolytic potency is sensitive to alterations in structure throughout the entire length of the ACTH sequence in the rat fat cell assay.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001717:Birds; D006801:Humans; D007202:Indicators and Reagents; D008066:Lipolysis / Q000187:drug effects; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014422:Turkeys
D007202:Indicators and Reagents; D000324:Adrenocorticotropic Hormone