Axon membrane remodeling in the lead-induced demyelinating neuropathy of the rat.
Single-teased fibers stained with the ferric ion-ferrocyanide method allowed us to study axonal remodeling in the lead-induced demyelinating neuropathy of the rat. Our findings, in agreement with recent physiological data, pointed to a transitory reorganization of the demyelinated axons to maintain impulse conduction until remyelination and formation of new cytochemically normal nodes had restored a secure saltatory conduction.
D000818:Animals; D001369:Axons / Q000473:pathology; D002462:Cell Membrane / Q000473:pathology; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000473:pathology; D007473:Ion Channels / Q000378:metabolism; D007855:Lead Poisoning / Q000378:metabolism / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D012964:Sodium