[Current aspects of chemotaxis of phagocytic cells].
Phagocytic cells, the first host defence against microbial attack, are remarkably mobile; they can move very rapidly to the infectious or inflammatory site. They migrate toward a chemotactic factor: C5a, lymphokines, bacterial products, leukotriene B4, etc. The binding of the chemotactic factor to its specific receptor on the cell leads to an activation of the phagocytic cell: the electric potential of the membrane changes, ionic fluxes and free calcium rate increase, arachidonic acid metabolites are produced, cyclic nucleotides are activated. This produces a change in shape, a polarization of the cell and, after cytoskeleton reorganization, migration of the cell towards the chemotactic factor. A constitutional or acquired abnormality of one of these steps induces a defect of chemotaxis for the phagocytic cells and severe infections.
D001426:Bacterial Proteins / Q000096:biosynthesis; D002118:Calcium / Q000378:metabolism; D002630:Chemotactic Factors / Q000096:biosynthesis*; D003182:Complement C5 / Q000096:biosynthesis; D015936:Complement C5a; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D007975:Leukotriene B4 / Q000096:biosynthesis; D008222:Lymphokines / Q000096:biosynthesis; D008564:Membrane Potentials; D009712:Nucleotides, Cyclic / Q000378:metabolism; D010585:Phagocyte Bactericidal Dysfunction / Q000503:physiopathology; D010587:Phagocytosis
D001426:Bacterial Proteins; D002630:Chemotactic Factors; D003182:Complement C5; D008222:Lymphokines; D009712:Nucleotides, Cyclic; D007975:Leukotriene B4; D015936:Complement C5a; D002118:Calcium
Aspects actuels de la chimiotaxie des cellules phagocytaires.