Indomethacin and sulindac inhibition of ACTH stimulated cortisol release from adrenal glands in vitro.
In slices of adrenal glands of guinea pig added ACTH (from femtograms to picograms levels) stimulates cortisol synthesis and release. This effect is antagonized in a non-linear competitive way by indomethacin (KE = 1.3 .10(-7)) and by sulindac (KI = 6.9 .10(-10)); indoprofen is a very weak antagonist. A number of other non-steroid antiinflammatory drug are ineffective as antagonists of ACTH.
D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000037:antagonists & inhibitors*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000378:metabolism*; D066298:In Vitro Techniques; D007192:Indenes / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D013467:Sulindac / Q000494:pharmacology*
D007192:Indenes; D013467:Sulindac; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D007213:Indomethacin