Serotonin-receptor coupled with membrane electrogenesis in a rat glioma clone.
The electrophysiological consequences of serotonin application to glial cells in culture are described. Membrane hyperpolarization due to K+ permeability-increment was induced by serotonin in rat clonal glioma (C6-BU-1) cells. Similar response was recognized in some of rat cerebral cortical glial cells. Pharmacological examinations in the C6-BU-1 glioma cells suggested a participation of serotonin-receptors sharing properties known in neuronal receptors.
D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005910:Glioma / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D009457:Neuroglia / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects
D007473:Ion Channels; D011985:Receptors, Serotonin; D012701:Serotonin; D011188:Potassium