Metabolism of adenosine-3', 5'-cyclic monophosphate in the liver of rats treated with nicotinamide.
Nicotinamide injected in a high dose (100 mg/100 g body weight) into rats induces several variations both of enzymatic activities and of metabolites levels. We have tested the effect of NAm on liver cAMP content; it increases reaching a peak at the second hour after treatment. Liver adenylate cyclase and 3',5'-cyclic AMP phosphodiesterase activities have been tested; the former increases reaching a peak after 1 hour, while the latter decreases consistently one hour after treatment. This variation of cAMP phosphodiesterase activity could be related to the change of the pyridine coenzymes redox state observed after NAm injection. The increase of the liver cAMP concentration could explain the mobilization of glucose after treatment with NAm, and the alteration of several enzymatic activities, as serine dehydratase, observed after treatment.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009536:Niacinamide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009536:Niacinamide; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000262:Adenylyl Cyclases