title: The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions.
abstract: The human c-Ha-ras2 gene, one of two known members of the Harvey ras family, is reportedly located on the X-chromosome and has lost introns (1, 2). There has heretofore been no information on its precise gene structure and oncogenic potential. We have determined the nucleotide sequence of the c-Ha-ras2 and demonstrate that it is a processed pseudogene surrounded by several direct repeats and contains numerous base substitutions as well as a notable mutation (AGT at codon 12 of the p21 protein) responsible for oncogenic conversion of the known ras genes (3-8).
mesh_terms: D001482:Base Composition; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D003001:Cloning, Molecular; D004251:DNA Transposable Elements; D005260:Female; D005814:Genes, Viral; D006251:Harvey murine sarcoma virus / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009857:Oncogenes; D009053:Sarcoma Viruses, Murine / Q000235:genetics*; D014960:X Chromosome / Q000502:physiology*
chemical_list: D004251:DNA Transposable Elements