Paradoxical sleep rebound without previous debt: the effect of minute doses of clonidine in man.
This report describes an experimental condition in which clonidine administration does not modify paradoxical sleep (PS) directly, but is followed by a secondary rebound. After oral consumption of minute doses of clonidine (CLN), 12 subjects showed no direct effect of CLN, but showed a significant increase of PS production in the following placebo night. Four other subjects experienced a decrease of PS under CLN and no rebound the next night. In addition, these four subjects had mechanisms of slow wave sleep production significantly weaker than the first 12 subjects.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001921:Brain / Q000187:drug effects; D002415:Cats; D003000:Clonidine / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D012892:Sleep Deprivation; D012895:Sleep, REM / Q000187:drug effects*
D011942:Receptors, Adrenergic, alpha; D003000:Clonidine