Herpes simplex virus-induced demyelination. Effects of reinfection and challenge with neuroantigens.
Mice injected into the snout with the F-strain of herpes simplex virus (HSV) showed demyelination in the central part of the trigeminal root and brainstem. In this well characterized model the effect of reinfection with a virulent strain of HSV, and of immunization with UV-light-inactivated HSV and neuroantigens were examined. A marked enhancement of demyelination was found in mice immunized with spinal cord extracts in Freund's adjuvant prior to the HSV infection. Whether this effect is mediated by a general stimulation of inflammatory or immune competent cells or is dependent upon exposure to specific antigens is not known.
D000818:Animals; D001927:Brain Diseases / Q000209:etiology; D001933:Brain Stem; D003389:Cranial Nerve Diseases / Q000209:etiology; D003711:Demyelinating Diseases / Q000209:etiology*; D004195:Disease Models, Animal; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006566:Herpesviridae Infections / Q000150:complications*; D007114:Immunization; D008297:Male; D051379:Mice; D012008:Recurrence; D013116:Spinal Cord / Q000276:immunology; D014276:Trigeminal Nerve
D005620:Freund's Adjuvant