Regulation of B cell lymphomagenesis by a malignant Qal+ inducer T cell clone.
A series of Thy-1.2+ Ly-1+ Qa-1+ malignant T cell clones have been isolated from murine sarcoma virus-murine leukemia-Moloney (MSV-MuLV-M)-induced B cell lymphomas or from MSV-MuLV-M-infected B6 mice. These T cell clones enhance both antigen-independent and -dependent lymphocyte differentiation and function. They also induce the differentiation of granulocytes and erythrocytes in the stem cell compartment, a function that parallels the immunopathology of the disease in vivo. The malignant T cell appears to sustain B lymphoma growth in vivo by releasing a factor (BCGF) that promotes B cell proliferation.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002472:Cell Transformation, Viral; D002999:Clone Cells / Q000276:immunology; D005260:Female; D006098:Granulocytes / Q000473:pathology; D006410:Hematopoiesis; D006462:Hemolytic Plaque Technique; D015395:Histocompatibility Antigens Class I; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000097:blood / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009053:Sarcoma Viruses, Murine / Q000276:immunology; D012513:Sarcoma, Experimental / Q000097:blood / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens