Cyclic AMP dependent protein kinase and its endogenous inhibitor protein: tissue distribution and effect of vitamin D status in the chick.
1. Vitamin D deficiency in the chick leads to decreased (to 55% of normal) cyclic AMP-dependent protein kinase activity in the kidney but does not alter calcium-dependent phospholipid-sensitive protein kinase activity. 2. Decreased cyclic AMP-dependent protein kinase activity in response to vitamin D deficiency was not observed in other tissues including pancreas, brain, liver, intestinal mucosa, or heart. 3. Vitamin D deficiency leads to elevated levels of the endogenous inhibitor protein of cyclic AMP-dependent protein kinase in kidney, but not heart, muscle, pancreas, or brain.
D000818:Animals; D002352:Carrier Proteins / Q000032:analysis*; D002645:Chickens; D000242:Cyclic AMP / Q000494:pharmacology*; D047908:Intracellular Signaling Peptides and Proteins; D011494:Protein Kinases / Q000032:analysis*; D014808:Vitamin D Deficiency / Q000201:enzymology*
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C015482:protein kinase modulator; D000242:Cyclic AMP; D011494:Protein Kinases