The influence of piracetam on the cyclic adenosine monophosphate (cAMP) concentration in the brain and colon of guinea pigs.
During investigations of 2-oxy-pyrrolidine-acetamide (piracetam, Nootrop) the influence on the cyclic adenosine monophosphate (cAMP) level was measured. 20 guinea pigs (inbred albinos) were used for the investigations. 6 animals served as a control group, 14 animals were treated daily for 16 days with 35 mg piracetam/kg b.w. The cAMP concentration was determined in the frontal brain and intestine. The animals treated 16 days with piracetam showed an increase of cAMP in the frontal brain of 134% compared with untreated animals. In the intestinal tissue, the difference between the control group and the piracetam-treated animals ranged around 84%.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006168:Guinea Pigs; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*
D011760:Pyrrolidinones; D000242:Cyclic AMP; D010889:Piracetam