title: Transferrin binding by peripheral blood mononuclear cells in human lymphomas, myelomas and leukemias.
abstract: Significantly more peripheral blood mononuclear cells (PBM) from 39 patients with lymphoma (p less than 0.001), myeloma (p less than 0.001), or leukemia (p less than 0.001-0.025) bind transferrin (Trf) than those of 23 normals. That Trf was bound to a receptor on these cells was shown by the inhibition of these cells bound to 125I-Trf with unlabeled Trf. The paucity of Trf receptors on PBM from normals and their presence on diseased cells prompt a suggestion that Trf receptors may offer a useful approach to the diagnosis and possible treatment of some blood dyscrasias.
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D008214:Lymphocytes / Q000378:metabolism*; D008223:Lymphoma / Q000276:immunology*; D009101:Multiple Myeloma / Q000276:immunology*; D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D014168:Transferrin / Q000378:metabolism
chemical_list: D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D014168:Transferrin