Allergic contact dermatitis from a novel diamino intermediate, 5-[(2-aminoethyl)thiomethyl]-N, N-dimethyl-2-furanmethanamine, in laboratory synthesis.
Allergic contact sensitivity to 5-[(2-aminoethyl)thiomethyl]-N, N-dimethyl-2-furanmethanamine, a diamino intermediate in the synthesis of a novel H2 antagonist, Ranitidine is reported in an industrial chemist with hand dermatitis, who had been working for a prolonged period on the conversion of this intermediate to its fumarate salt.
D000328:Adult; D002617:Chemical Industry; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D006229:Hand Dermatoses / Q000139:chemically induced; D006801:Humans; D008297:Male; D010328:Patch Tests; D011899:Ranitidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000138:chemical synthesis
C040001:5-((2-aminoethyl)thiomethyl)-N,N-dimethyl-2-furanmethanamine; D011899:Ranitidine