title: Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain.
abstract: A total of 5724 base pairs of a recombinant phage DNA containing a human HLA-DR heavy chain gene including flanking regions has been analyzed. The regions corresponding to all the exons have been identified. The sites of initiation of transcription and polyadenylation have been determined. A large intron of 2399 base pairs separates the first exon containing the 5' untranslated region and the signal peptide from the second exon containing the N-terminal peptide domain.
mesh_terms: D000595:Amino Acid Sequence; D010582:Bacteriophage lambda / Q000235:genetics; D001482:Base Composition; D001483:Base Sequence; D003001:Cloning, Molecular; D004262:DNA Restriction Enzymes; D004274:DNA, Recombinant; D005260:Female; D005333:Fetus; D005796:Genes; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008099:Liver / Q000276:immunology; D008285:Major Histocompatibility Complex; D008970:Molecular Weight; D011247:Pregnancy; D014158:Transcription, Genetic
chemical_list: D004274:DNA, Recombinant; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D004262:DNA Restriction Enzymes