[Course of the vaccinal process induced by the vaccinia virus in cyclophosphane-suppressed cellular and humoral immunity].
Under conditions of immunosuppression of B- and T- cell function by cyclophosphane the vaccination process in mice immunized with vaccinia virus was considerably more severe than in the untreated animals: mortality in immunosuppressed mice was much higher than in the controls; the virus could be isolated from their lungs for longer periods and in higher titres; the number of antibody-producing cells in the spleen and antibody levels in the blood were lower. In contrast to the inactivated vaccine, live vaccine itself exerted a marked immunosuppressive effect.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003520:Cyclophosphamide / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007165:Immunosuppression Therapy / Q000379:methods*; D051379:Mice; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000276:immunology; D014616:Vaccinia virus / Q000276:immunology*; D012901:Variola virus / Q000276:immunology*
D014613:Vaccines, Attenuated; D003520:Cyclophosphamide
Techenie vaktsinal'nogo protsessa, vyzvannogo virusom ospovaktsiny, v usloviiakh kletochnogo i gumoral'nogo immuniteta tsiklofosfanom.