Biosynthesis of neurohypophysial hormones: historical and current events.
Properties of the neurohypophysial hormones and neurophysins are presented and historical events contributing to our present understanding of the biosynthesis of these molecules are reviewed. Recent findings, including cloning of mRNA and identification of putative giant precursors, are discussed in the context of precursor processing systems and possible biochemical and physiological mechanisms.
D000818:Animals; D004274:DNA, Recombinant / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D004723:Endorphins / Q000032:analysis; D008970:Molecular Weight; D009481:Neurophysins / Q000096:biosynthesis; D010121:Oxytocin / Q000032:analysis; D010909:Pituitary Hormones, Posterior / Q000096:biosynthesis* / Q000235:genetics; D011498:Protein Precursors / Q000096:biosynthesis; D014667:Vasopressins / Q000032:analysis; D001615:beta-Endorphin
D004274:DNA, Recombinant; D004723:Endorphins; D009481:Neurophysins; D010909:Pituitary Hormones, Posterior; D011498:Protein Precursors; D014667:Vasopressins; D010121:Oxytocin; D001615:beta-Endorphin