title: Ethanol dependence and the pituitary adrenal axis in mice. II. Temporal analysis of dependence and withdrawal.
abstract: The effects of ethanol dependence and withdrawal on pituitary hormone content and corticosterone release were investigated in AKR/J male mice in a vapor chamber. Both chronic ethanol inhalation and ethanol withdrawal were associated with increased adenohypophyseal-adrenocortical activity. Operationally, ethanol exposure was a stressor. Both physical dependence and withdrawal led to increased secretion/synthesis ratios of peptide hormones. The temporal pattern of pituitary ACTH-IR content changes was different from that of beta-endorphin-IR and alpha-MSH-IR. Differences in the pattern of ACTH-IR and alpha-MSH-IR most probably represent lobe-specific differences in the response to chronic ethanol exposure and withdrawal.
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004723:Endorphins / Q000378:metabolism; D006801:Humans; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism; D051379:Mice; D008806:Mice, Inbred AKR; D010902:Pituitary Gland / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D001615:beta-Endorphin
chemical_list: D004723:Endorphins; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D009074:Melanocyte-Stimulating Hormones; D003345:Corticosterone