Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity.
Copolymers of N-(2-hydroxypropyl)methacrylamide which contained up to 20 mol % of p-nitrophenyl esters of N-methacryloylated oligopeptides, and of N-methacryloylaminophenoxyacetic acids (o-, m-, p-) have been prepared. The aminolyses of these polymers with tert. butylamine, ampicillin and 6-aminopenicillanic acid were kinetically characterized. Based on these results polymer bound ampicillin and polymer bound 6-aminopenicillanic acid were prepared. These preparations possessed antimicrobial activity; they inhibited the growth of Staphylococcus aureus 209 P.
D000179:Acrylates / Q000138:chemical synthesis*; D000667:Ampicillin; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D007700:Kinetics; D008689:Methacrylates / Q000138:chemical synthesis* / Q000494:pharmacology; D010397:Penicillanic Acid / Q000031:analogs & derivatives
D000179:Acrylates; D000900:Anti-Bacterial Agents; D008689:Methacrylates; D000667:Ampicillin; D010397:Penicillanic Acid; C004408:aminopenicillanic acid; C029639:2-hydroxypropyl methacrylate