title: Gene duplications in poliovirion RNA.
abstract: Two intragenomic homologous sequence pairs were detected in poliovirion type 1 (Mahoney) RNA. An RNA sequence region N3729-N4118 (by the numbering of Kitamura et al. (ref. 1)) coding for P2-3b was found to share 39% identical bases in 360 aligned positions with another region N5007-N5366 encoding P2-X and P3-1b. An RNA segment N3381-N3558 coding for the N-terminal portion of P2-3b was shown to have 42% identical bases in 178 positions aligned with N5979 -N6161 which encodes the N-terminal sequence of P3-4b (RNA-dependent RNA polymerase). A statistical technique developed here for evaluating nucleotide sequence homologies demonstrated highly significant homology levels, P less than 10(-8) for the former alignment and P less than 10(-5) for the latter.
mesh_terms: D001483:Base Sequence; D005814:Genes, Viral; D007700:Kinetics; D008433:Mathematics; D008957:Models, Genetic; D017955:Poliovirus / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics*
chemical_list: D012367:RNA, Viral