2',3'-cyclic nucleotide 3'-phosphodiesterase and 5'-nucleotidase in the central nervous system of a myelin-deficient rat mutant.
2',3'-Cyclic nucleotide 3'-phosphodiesterase activity was examined in brains and spinal cords of normal and myelin-deficient Wistar rats. While the activity in normal brains increased from 0.2 mumol/min/mg protein (units) at 6-10 days to 3.5 units at 25 days of postnatal age, the activity in the myelin-deficient rat remained at 0.2-0.3 units over the same period. In spinal cord, the normal activities were 5.7 and 10.9 units at 12 and 20 days, respectively, whereas they declined in the myelin-deficient rat from 1.06 to 0.79 units for the same age points. 5'-Nucleotidase activities in brain and spinal cord were normal in the myelin deficient rat at both ages.
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism*; D015720:5'-Nucleotidase; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003711:Demyelinating Diseases / Q000201:enzymology*; D009708:Nucleotidases / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D013045:Species Specificity; D013116:Spinal Cord / Q000201:enzymology*
D009708:Nucleotidases; D015720:5'-Nucleotidase; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D010727:Phosphoric Diester Hydrolases