title: Long-lasting potentiation of the dentate gyrus population spike by norepinephrine.
abstract: The effects of iontophoretically applied norepinephrine (NE) on the dentate gyrus field potential evoked by perforant path stimulation were examined. NE potentiated the population spike by 20-400%, whereas the population EPSP was rarely increased. At 39% of the potentiated sites NE application resulted in long-lasting potentiation (LLP) suggesting a role for NE in long-term hippocampal plasticity.
mesh_terms: D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007478:Iontophoresis; D009473:Neuronal Plasticity; D009638:Norepinephrine / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D009638:Norepinephrine