Estimation of hemopoietic potential by CFU-c and bone marrow scan in cancer patients.
The concentration of granulocyte-macrophage colonies in culture (CFU-c) in bone marrow cells was estimated, and bone marrow radionuclide scans were performed in a group of 15 cancer patients prior to bone marrow harvest for autologous transplantation. Preharvest CFU-c counts on iliac-crest bone marrow aspirates correlated very well with CFU-c counts from fresh and frozen-thawed bone marrows. Technetium-99m-sulfur colloid radionuclide scans showed that the distribution of total-body bone marrow and increased peripheral radionuclide uptake correlated with higher preharvest and harvest CFU-c counts. Bone marrow scan results were available in 1 h, whereas CFU-c counts took 14 days to obtain. Bone marrow scans may facilitate the clinical estimation of hemopoietic activity in patients under consideration for autologous bone marrow transplantation.
D001853:Bone Marrow / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000473:pathology; D008175:Lung Neoplasms / Q000097:blood / Q000473:pathology; D008223:Lymphoma / Q000097:blood / Q000473:pathology; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000473:pathology; D011877:Radionuclide Imaging; D013455:Sulfur; D013667:Technetium; D013671:Technetium Tc 99m Sulfur Colloid; D013736:Testicular Neoplasms / Q000097:blood / Q000473:pathology
D013671:Technetium Tc 99m Sulfur Colloid; D013455:Sulfur; D013667:Technetium