title: Postsynaptic actions of ethanol and methanol in crayfish neuromuscular junctions.
abstract: Actions of ethanol and methanol on excitatory postsynaptic channels activated by quisqualate were investigated in opener muscles from the first walking leg and the claw of crayfish. Both ethanol and methanol reduced the elementary currents [i] that flow through channels operated by quisqualate in a concentration-dependent manner but did not affect the apparent mean open time, tau noise, of the channels estimated from power spectra. 0.26 mol/l ethanol, or 1 mol/l methanol, respectively, reduced [i] e-fold. Ethanol also markedly decreased the size and the decay time constant tau (sEPSCs) of spontaneous excitatory postsynaptic currents (sEPSCs). At ten fibres, on the average, 0.26 mol/l ethanol decreased tau (sEPSCs) by a factor 1.56 +/- 0.24 (SD). tau (sIPSCs) and tau noise of inhibitory postsynaptic currents apparently were not affected by ethanol. Moreover the size of elementary inhibitory postsynaptic currents did not decrease in the presence of this alcohol. Thus, in crayfish opener muscles ethanol seems to selectively depress excitatory postsynaptic currents.
mesh_terms: D000818:Animals; D003386:Brachyura / Q000502:physiology*; D004594:Electrophysiology; D000431:Ethanol / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D000432:Methanol / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D013569:Synapses / Q000187:drug effects*
chemical_list: D007473:Ion Channels; D010069:Oxadiazoles; D000431:Ethanol; D016318:Quisqualic Acid; D000432:Methanol