Effect of a vitamin A-free diet on [3H]diazepam and [3H]GABA binding in the rat retina.
Benzodiazepine and GABA binding sites in the rat retina are influenced by a vitamin A-free diet. In rats fed a vitamin A-free diet, the total number of [3H]GABA and [3H]diazepam binding sites was markedly higher than in rats given a balanced diet. No differences were found in the apparent affinities of [3H]GABA and [3H]diazepam for their specific binding sites. The results suggest that GABA and benzodiazepine binding sites have a role in the function of the retina.
D000818:Animals; D003975:Diazepam / Q000378:metabolism; D004032:Diet; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011963:Receptors, GABA-A; D012160:Retina / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000378:metabolism*
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D003975:Diazepam