Is prostacyclin subserving a vasodilator effect of methoxamine involving alpha adrenoreceptors?
The influence of methoxamine on the contractile tension of isolated rat abdominal aorta, and on its capacity to produce a platelet antiaggregating substance, were explored. Methoxamine stimulated platelet antiaggregation and diminished arterial tone. The last action was blocked by phentolamine as well as by inhibitors of cyclo-oxygenase and prostacyclinsynthetase.
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000502:physiology*; D011464:Epoprostenol / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008729:Methoxamine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D010974:Platelet Aggregation; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D014665:Vasodilator Agents
D011453:Prostaglandins; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D014665:Vasodilator Agents; D011464:Epoprostenol; D008729:Methoxamine; D007213:Indomethacin