Inverse correlation between estrogen receptor content and peroxidase activity in human mammary tumors.
Identification and characterization of cytoplasmic estrogen receptor gave a biochemical basis for mammary hormone dependence, nevertheless, hormone receptor determination is not enough to allow us a complete prediction of hormone dependence thus search for new biochemical markers is a goal for experimental oncologists. In the present communication we report an inverse correlation between peroxidase activity in the human breast tumor tissue and the percentage of positive estrogen receptor in a group of 50 patients. Thus preliminary interpretation can be done about the actual role of this enzyme in relation to hormone dependence.
D001943:Breast Neoplasms / Q000032:analysis* / Q000201:enzymology; D003593:Cytoplasm / Q000032:analysis; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008861:Microsomes / Q000201:enzymology; D009195:Peroxidase; D010544:Peroxidases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000032:analysis*
D007527:Isoenzymes; D011960:Receptors, Estrogen; D010544:Peroxidases; D009195:Peroxidase