"Pertussis toxin induces tachycardia and impairs the increase in blood pressure produced by alpha 2-adrenergic agonists".
Administration of purified pertussis toxin to rats induced persistent tachycardia, (observed in conscious rats but not after pithing); as little as 0.05 microgram/100 g produced a significant effect. Pertussis toxin-treatment did not affected the pressor response produced in the pithed rats by the alpha 2-adrenergic agonist methoxamine but markedly diminished the pressor effect of the alpha 2-adrenergic agonists clonidine and azepexole. A role of adenylate cyclase inhibition in the action of postsynaptic vascular alpha 2-adrenergic receptors is suggested.
D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001427:Bacterial Toxins / Q000633:toxicity*; D001794:Blood Pressure / Q000187:drug effects*; D001886:Bordetella pertussis; D003000:Clonidine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D013610:Tachycardia / Q000139:chemically induced* / Q000503:physiopathology
D001381:Azepines; D001427:Bacterial Toxins; D011942:Receptors, Adrenergic, alpha; C015603:azepexole; D008729:Methoxamine; D003000:Clonidine