Synthesis and structural study of N-substituted nortropane spirohydantoins.
A series of N8-alkyloxycarbonylalkyl-nortropane-3-spiro-5'-hydantoins has been synthesized and studied by spectral and crystallographic methods. The crystal and molecular structure of one [8(gamma-ethoxycarbonyl)nortropane-3-spiro-5'-hydantoin, VI] was determined by X-ray diffraction. The preferred conformations of these compounds and subsequent changes on protonation were determined from 1H-NMR and 13C-NMR data.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003903:Deuterium; D017666:Deuterium Oxide; D004121:Dimethyl Sulfoxide; D006827:Hydantoins / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009662:Nortropanes / Q000138:chemical synthesis*; D014867:Water
D006827:Hydantoins; D009662:Nortropanes; D014867:Water; D003903:Deuterium; D017666:Deuterium Oxide; D004121:Dimethyl Sulfoxide