Efficacy of antifungal agents in the cornea. II. Influence of corticosteroids.
The influence of topical corticosteroid on the efficacy of five topical antifungal agents was evaluated in a standardized rabbit model of Candida keratitis using a quantitative mycologic technique. Topical 1% prednisolone acetate worsened the disease when given alone and adversely influenced the efficacy of 5% natamycin, 1% flucytosine, and 1% miconazole when given in combination. The efficacy of amphotericin B appeared unaffected when the antifungal agent was administered in concentrations of 0.5% and 0.15%. The adverse effect of the topical corticosteroid appeared to be inversely related to the efficacy of the antifungal agent in vivo.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000008:administration & dosage / Q000494:pharmacology; D007634:Keratitis / Q000188:drug therapy* / Q000382:microbiology; D007654:Ketoconazole / Q000008:administration & dosage / Q000494:pharmacology; D008825:Miconazole / Q000008:administration & dosage / Q000494:pharmacology; D010866:Natamycin / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits
D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D008825:Miconazole; D000666:Amphotericin B; D010866:Natamycin; D005437:Flucytosine; D007654:Ketoconazole