Investigation of a sub-unit vaccine using an animal model of herpes simplex keratitis.
A rabbit and a mouse model of herpes simplex eye disease have been used to evaluate a sub-unit herpes simplex vaccine. Various immunization schedules were investigated. The vaccine was found to stimulate humoral and cellular immune responses and to offer protection against corneal infection with liver herpes simplex virus.
D000818:Animals; D003315:Cornea / Q000382:microbiology; D004195:Disease Models, Animal; D007115:Immunization Schedule; D007074:Immunoglobulin G / Q000032:analysis; D007635:Keratitis, Dendritic / Q000382:microbiology / Q000517:prevention & control*; D051379:Mice; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology*; D013997:Time Factors; D014276:Trigeminal Nerve / Q000382:microbiology; D014765:Viral Vaccines / Q000276:immunology* / Q000627:therapeutic use
D007074:Immunoglobulin G; D014765:Viral Vaccines