Different dose-response relationships in the induction of different types of colonic tumors in Wistar rats by 1,2-dimethylhydrazine.
Four groups of 21 male Wistar rats were given weekly subcutaneous injections of 1,2-dimethylhydrazine at a dose of 20 mg/kg body weight for 2, 4, 6 and 8 weeks, respectively, and 7 animals of each group were killed in weeks 24, 32 and 40. This treatment induced a clear dose-related increase in the total number of colonic carcinomas. The number of tubular adenocarcinomas, which were mostly located in the descending colon, was clearly dose-related, whereas the number of signet ring cell carcinomas, which developed in the ascending colon, was apparently dose-independent.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004127:Dimethylhydrazines; D004305:Dose-Response Relationship, Drug; D008297:Male; D008763:Methylhydrazines; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D004127:Dimethylhydrazines; D008763:Methylhydrazines