Natural killing of cytomegalovirus-infected targets in renal transplant recipients.
The ability of peripheral blood mononuclear cells of renal transplant recipients to lyse cytomegalovirus (CMV) infected fibroblasts was determined in an 18-hr 51Cr release assay. Natural killing (NK) against CMV-infected targets was generally depressed for the first two years after transplantation. In three individuals who developed CMV disease after transplantation, NK activity against CMV-infected and uninfected targets rose to high levels following reductions in immunosuppressive therapy and in temporal association with resolution of disease.
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage; D003586:Cytomegalovirus Infections / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation; D007694:Killer Cells, Natural / Q000276:immunology*; D008134:Long-Term Care; D011183:Postoperative Complications / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage
D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone