The susceptibility of Neisseria gonorrhoeae isolated in Singapore to ceftriaxone, cefotaxime, gentamicin and cotrimoxazole.
240 and 183 strains of non-PPNG and PPNG isolated in 1981 were studied for their susceptibility to ceftriaxone and cefotaxime respectively. All the strains were susceptible to 0.016 microgram/ml of either antibiotic. PPNG from males were less susceptible to cefotaxime than non-PPNG or PPNG from females. PPNG isolated in 1979 were less susceptible to gentamicin than non-PPNG. The relatively high MIC values of cotrimoxazole may account for the high treatment failure rate encountered with the drug.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D015310:Cefotiam; D002443:Ceftriaxone; D004338:Drug Combinations / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000378:metabolism; D010405:Penicillinase / Q000096:biosynthesis; D012737:Sex Factors; D012846:Singapore; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005839:Gentamicins; D002443:Ceftriaxone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015310:Cefotiam; D014295:Trimethoprim; D010405:Penicillinase; D013420:Sulfamethoxazole; D002439:Cefotaxime