Ectopic ACTH-, beta-LPH- and beta-endorphin-producing metastatic carcinoma of the lung from the tonsil.
A rare case of metastatic lung cancer from the tonsil associated with ectopic ACTH, beta-LPH and beta-endorphin production was presented. A year ater the tonsillectomy and lymphadenectomy, the patient had metastatic lung cancer. Three years later he died. Brown pigmentation remained evident for a month before his death. Both ACTH and cortisol levels were high in the plasma. ACTH, beta-LPH and beta-endorphin were found in the tissue extracts (squamous cell carcinoma).
D000182:ACTH Syndrome, Ectopic / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D004723:Endorphins / Q000096:biosynthesis*; D006729:Hormones, Ectopic / Q000096:biosynthesis*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary*; D008297:Male; D014067:Tonsillar Neoplasms / Q000378:metabolism*; D001615:beta-Endorphin; D008083:beta-Lipotropin / Q000096:biosynthesis*
D004723:Endorphins; D006729:Hormones, Ectopic; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin