Do convergent neurones in the spinal dorsal horn discriminate nociceptive from non-nociceptive information?
Thirty convergent neurones responding to both noxious and non-noxious cutaneous stimuli were recorded at the lumbar level in either anaesthetized 'intact' rats or unanaesthetized 'spinal' rats. Their responses to radiant heat application and to repetitive innocuous mechanical stimulation of the centre of their receptive fields were analysed, both in terms of the maximal and the mean firing rates. These neurones increased their discharge rates in relation to the temperature applied to their receptive fields with the highest levels being produced by noxious intensities. This finding confirms earlier reports suggesting the capacity of these neurones to encode nociceptive information of thermal origin. However, a very high level of firing could also be evoked by repetitively applied innocuous mechanical stimuli. This was a consistent finding, observed both in intact and spinal animals, which was true for the two subgroups into which we divided the convergent neurones (warming/noxious heat units and noxious heat units). These results are discussed in terms of the role of convergent neurones in nociception. It is suggested that a single channelled signal emanating from these neurones could not be the basis of a clear nociceptive message to the brain; two alternative hypotheses involving multichannelled organizations of impulses are proposed for discussion.
D000818:Animals; D004192:Discrimination, Psychological / Q000502:physiology*; D005073:Evoked Potentials, Somatosensory; D005727:Ganglia, Spinal / Q000502:physiology*; D006614:Hindlimb / Q000294:innervation; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000294:innervation*; D009435:Synaptic Transmission; D013823:Thermoreceptors / Q000502:physiology