Phosphate derivatives of thiamine and Na+ channel in conducting membranes.
The results show that thiamine derivatives are copurified with the specific proteins forming the Na+ channel in conducting membranes. Therefore, thiamine derivatives could well play a specific role in the molecular aspects of bioelectrogenesis , an interpretation that could help explain the neurological symptoms observed in human pathology as well as in animals experimentally rendered deficient in vitamin B1.
D000818:Animals; D002352:Carrier Proteins / Q000032:analysis; D004557:Electric Organ / Q000032:analysis*; D004593:Electrophorus; D007473:Ion Channels / Q000032:analysis*; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels; D013779:Tetrodotoxin / Q000378:metabolism; D013831:Thiamine / Q000302:isolation & purification*; D013833:Thiamine Monophosphate / Q000302:isolation & purification; D013835:Thiamine Pyrophosphate / Q000302:isolation & purification; D013838:Thiamine Triphosphate / Q000302:isolation & purification; D014701:Veratridine / Q000494:pharmacology
D002352:Carrier Proteins; D007473:Ion Channels; D015222:Sodium Channels; C023790:tetrodotoxin-binding protein; D013838:Thiamine Triphosphate; D013779:Tetrodotoxin; D013833:Thiamine Monophosphate; D014701:Veratridine; D012964:Sodium; D013835:Thiamine Pyrophosphate; D013831:Thiamine