Mechanisms determining innate resistance to ectromelia virus infection in C57BL mice.
The mechanism for innate resistance to ectromelia virus, which is controlled by a single gene in C57BL mice, was investigated. The cells or factors involved appear to be radioresistant and to impose an early barrier to viral penetration and spread via lymphatics or blood to the target organs, i.e., liver and spleen.
D000818:Animals; D004481:Ectromelia virus / Q000254:growth & development; D004482:Ectromelia, Infectious / Q000235:genetics / Q000276:immunology*; D005260:Female; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL / Q000276:immunology*; D011213:Poxviridae Infections / Q000276:immunology*; D011828:Radiation Chimera
D006183:H-2 Antigens