Oscillations of cAMP with the cardiac cycle.
Oscillations of cAMP with the cardiac cycle were demonstrated in the rat heart using a stimulator-triggered rapid freeze-clamp to decrease the temperature of the heart from 37 degrees C to -80 degrees C in 5 msec (20,000 degrees/sec) at a predetermined phase of the cardiac cycle. The nucleotide, cAMP, oscillated 60% with the cardiac cycle during normal working conditions, the higher cAMP value occurring during systole.
D000818:Animals; D003080:Cold Temperature; D000242:Cyclic AMP / Q000378:metabolism*; D006321:Heart / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D010477:Perfusion; D051381:Rats
D000242:Cyclic AMP