Combined hemoperfusion-hemodialysis in severe poisoning: kinetics of drug extraction.
We studied the kinetics of drug extraction during a combined hemoperfusion-hemodialysis procedure for treatment of severely poisoned patients. In most drugs studied an overall clearance of 120-180 ml/min (at a blood flow of 200 ml/min) was obtained, the relative contribution of hemoperfusion and hemodialysis being variable. A one-compartment pharmacokinetic model is presented that allows calculation of the optimal treatment time as a function of the extracorporeal clearance and the distribution volume of the toxic agent. For some drugs two-compartment kinetics were observed during treatment. The behaviour during treatment of these drugs is illustrated with computer simulation.
D006207:Half-Life; D006464:Hemoperfusion; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011041:Poisoning / Q000628:therapy*; D006435:Renal Dialysis; D013997:Time Factors
D004364:Pharmaceutical Preparations