Analysis of the insulin gene in noninsulin-dependent diabetes.
That diabetes is a metabolic disorder characterized by insulin deficiency is well known. However, the nature and cause of this insulin lack are still to be determined. Recently devised analytical methods, resulting from recombinant DNA technology, have enabled us to study the process of insulin production in man and in experimental animals. The results of these studies suggest that the insulin-secretory defect in diabetes may be secondary to impaired synthesis.
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000032:analysis; D004262:DNA Restriction Enzymes; D004251:DNA Transposable Elements; D004274:DNA, Recombinant; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D004586:Electrophoresis; D005796:Genes; D006801:Humans; D007328:Insulin / Q000096:biosynthesis / Q000235:genetics*; D007515:Islets of Langerhans / Q000378:metabolism; D007962:Leukocytes / Q000032:analysis; D011110:Polymorphism, Genetic
D004251:DNA Transposable Elements; D004274:DNA, Recombinant; D007328:Insulin; D004247:DNA; D004262:DNA Restriction Enzymes