title: In vitro DNA synthesis by an alpha-like DNA polymerase bound to replicating simian virus 40 chromosomes.
abstract: Simian virus 40 chromosomes carry out replicative DNA synthesis in vitro which is sensitive to aphidicolin and to N-ethylmaleimide, resistant to 2',3'-dideoxythymidine-5'-triphosphate, and proportional to the amount of chromosome-associated alpha-like polymerase. Thus, an alpha-like DNA polymerase (alpha polymerase or delta polymerase) is responsible for in vitro DNA synthesis.
mesh_terms: D016590:Aphidicolin; D004257:DNA Polymerase II / Q000378:metabolism*; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D054306:Dideoxynucleotides; D004224:Diterpenes / Q000494:pharmacology; D005033:Ethylmaleimide / Q000494:pharmacology; D013539:Simian virus 40 / Q000201:enzymology*; D013942:Thymine Nucleotides / Q000494:pharmacology
chemical_list: D004279:DNA, Viral; D054306:Dideoxynucleotides; D004224:Diterpenes; D013942:Thymine Nucleotides; D016590:Aphidicolin; D004257:DNA Polymerase II; D004259:DNA-Directed DNA Polymerase; C017216:2',3'-dideoxythymidine triphosphate; D005033:Ethylmaleimide