Muraceins--muramyl peptides produced by Nocardia orientalis as angiotensin-converting enzyme inhibitors. I. Taxonomy, fermentation and biological properties.
Three muraceins , a family of muramyl peptides, were isolated from Nocardia orientalis as inhibitors of angiotensin-converting enzyme (ACE). Muracein A, the most potent inhibitor, inhibited ACE competitively with a Ki of 1.5 microM. Liver alcohol dehydrogenase and carboxypeptidase A, two other zinc-containing enzymes, were not inhibited at 150 microM. Inhibition of ACE could not be reversed by divalent cations.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000633:toxicity; D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D005285:Fermentation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009615:Nocardia / Q000145:classification / Q000254:growth & development*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C041439:muracein A; C041440:muracein B; C041441:muracein C; C041442:SQ 28370