[Glutamate decarboxylase activity in the hypophysis after changes in corticotropin levels in rats].
It was shown that glutamate decarboxylase is present in the whole hypophyses and its anterior pituitary lobe of experimental rats. Single and repeated hydrocortisone- and/or multiple desoxycorticosterone injections to intact rats led to a decrease in the hypophyseal glutamate decarboxylase activity. The enzyme activity remained unchanged after cyproheptadine use and lowered following nacom administration (the drugs, blocking corticotropin secretion). Adrenalectomy induced a sharp fall of the glutamate decarboxylase activity in the rat hypophyses. The enzyme activity returned completely to normal after cyproheptadine use and was partially stabilized following a single hydrocortisone injection in the hypophyses of adrenalectomized rats.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D003533:Cyproheptadine / Q000494:pharmacology; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D010902:Pituitary Gland / Q000201:enzymology*; D010903:Pituitary Gland, Anterior / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
D003533:Cyproheptadine; D005680:gamma-Aminobutyric Acid; D000324:Adrenocorticotropic Hormone; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase; D006854:Hydrocortisone
Aktivnost' glutamatdekarboksilazy v gipofize pri izmenenii urovnia kortikotropina v organizme u krys.