Isolation and characterization of a human interleukin 2 gene.
An interleukin 2 (IL-2) gene was isolated from a Charon 4A human gene library. Electron microscopic examination of 15 heteroduplexes formed between the genomic DNAs and the IL-2 cDNAs demonstrated that the size of the IL-2 gene is about 5.1 +/- 0.5 kb and that there are at least two introns in this gene. Nucleotide sequence of the 5' flanking region of the IL-2 gene showed a homology with that of the corresponding region of the human immune interferon gene.
D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000302:isolation & purification* / Q000378:metabolism; D004262:DNA Restriction Enzymes; D005796:Genes; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D008854:Microscopy, Electron; D009693:Nucleic Acid Hybridization; D014066:Palatine Tonsil / Q000378:metabolism; D010957:Plasmids; D012333:RNA, Messenger / Q000235:genetics
D007376:Interleukin-2; D012333:RNA, Messenger; D004247:DNA; D004262:DNA Restriction Enzymes