title: The current state of research with peripheral tissues in Huntington disease.
abstract: Huntington disease is a neurological autosomal dominant disease of unknown origin and the search for a suitable diagnostic marker has been extended to the peripheral tissues. It is generally believed that a membrane defect exists in Huntington disease although the evidence is controversial. It is the aim of this review to examine the validity of these claims for each of the peripheral tissues and techniques involved, and it is not intended to include all other aspects of research into Huntington disease.
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D001706:Biopsy; D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism*; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D007074:Immunoglobulin G / Q000276:immunology; D007621:Karyotyping; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D009154:Mutation; D011836:Radiation Tolerance; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013050:Spectrometry, Fluorescence; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
chemical_list: D007074:Immunoglobulin G; D005973:Glutamine; D005680:gamma-Aminobutyric Acid