Effect of lipoproteins on aldosterone production by isolated glomerulosa cells.
We have studied the effects of human high density and low density lipoproteins on adrenocorticotropin (ACTH)-induced aldosterone production by isolated glomerulosa cells obtained from lipoprotein-deficient rats. ACTH increased basal aldosterone production, and the addition of either lipoprotein fraction further enhanced ACTH-induced aldosterone production. This increase could be shown at physiological lipoprotein-cholesterol concentrations. These data are compatible with a role of both high density and low density lipoproteins in supplying cholesterol to aldosterone-secreting glomerulosa cells.
D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000096:biosynthesis*; D000818:Animals; D006801:Humans; D007700:Kinetics; D008074:Lipoproteins / Q000097:blood; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone