Photoaffinity labeling of P2-purinergic and H1-histamine receptors in intact smooth muscle.
This paper discusses the general applicability of photoaffinity labels as pharmacological receptor antagonists in functional studies of intact smooth muscle preparations. Guidelines are suggested that take into account the criteria for photoaffinity labeling studies as well as those for use with conventional antagonists.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives; D000345:Affinity Labels; D001386:Azides; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000031:analogs & derivatives; D007700:Kinetics; D009130:Muscle, Smooth / Q000032:analysis*; D010777:Photochemistry; D010782:Photolysis; D011956:Receptors, Cell Surface / Q000032:analysis*; D011968:Receptors, Histamine / Q000032:analysis*; D011969:Receptors, Histamine H1 / Q000032:analysis*; D011983:Receptors, Purinergic; D013329:Structure-Activity Relationship
C012761:3'-O-(3-(N-(4-azido-2-nitrophenyl)amino)propionyl)adenosine-5'-triphosphate; D000345:Affinity Labels; D001386:Azides; D011956:Receptors, Cell Surface; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011983:Receptors, Purinergic; D006632:Histamine; D000255:Adenosine Triphosphate