[Role of azlocillin in the treatment of immunocompromised patients. Results of the EORTC (European Organization for Research on the Treatment of Cancer) study)].
A multicentre clinical trial was organized by the International Antimicrobial Therapy Project Groups of the European Organisation for Research on the Treatment of Cancer (E.O.R.T.C.) to compare the effectiveness of three combinations of antibiotics (azlocillin + amikacin; cefotaxime + amikacin and ticarcillin + amikacin) in patients with malignant leukopenic and febrile diseases (polymorphonuclears less than 1000/mm3; temperature greater than 38.5 degrees C). Some 800 patients from 20 centres entered the study. Preliminary results in 421 assessable patients showed a 62% positive response rate. The response rate in patients with bacteraemia was twice as high in the azlocillin group than in the other groups, the difference being significant at p less than 0.02. This difference does not seem to be due to a distribution bias, since the responsible micro-organisms, the severity of granulopenia, the incidence of bacterial-resistant strains, etc., were similar in all three groups. Similarly, the death rate was 12% in the azlocillin-amikacin group as against 15% and 17% respectively in the other groups. It would appear from this trial that the azlocillin-aminoglycoside treatment is superior to the other antibiotic combinations tested in this category of patients.
D000380:Agranulocytosis / Q000150:complications*; D000583:Amikacin / Q000008:administration & dosage; D001390:Azlocillin; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D002439:Cefotaxime / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D009369:Neoplasms / Q000276:immunology*; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use*; D013982:Ticarcillin / Q000008:administration & dosage
D010406:Penicillins; D000583:Amikacin; D013982:Ticarcillin; D001390:Azlocillin; D002439:Cefotaxime
Place de l'azlocilline dans le traitement des malades immunodéprimés. Résultats de l'étude de l'E.O.R.T.C.