A model eliciting transient responses.
A simple parametrically controlled chemical transformation scheme is used to exemplify a model with transient response to sustained stimulation. More complicated schemes are also discussed. Analyses of three experimental examples are given: short-circuit current changes in toad bladder exposed to adenosine 3',5'-cyclic monophosphate (cAMP) stimulation; histamine secretion in acetylcholine-stimulated frog gastric mucosa; and cAMP dynamics, expressed in terms of adenylate cyclase dynamics, in histamine-stimulated frog gastric mucosa. The model responds primarily to the changes of the stimulator level, although it is not a model with derivative control.
D000109:Acetylcholine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001001:Anura; D002024:Bufo marinus; D000242:Cyclic AMP / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D006636:Histamine Release; D008433:Mathematics; D008954:Models, Biological; D001743:Urinary Bladder / Q000187:drug effects
D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D000109:Acetylcholine