Enovid-induced exacerbation of the propensity for stroke in low protein fish diet-fed stroke-prone/SHR.
Weanling, male and female, stroke-prone, spontaneously hypertensive rats (SP/SHR) were fed either a regular diet, a low protein diet derived from fish tissue + 1% saline drinking water, or the fish diet + 1% saline + daily injections of 0.1 mg Enovid/100 g bw/sc. After 48 days, the Enovid-treated animals developed acute and lethal strokes characterized by massive thrombonecrogenic lesions of the parietal lobe. The blood pressure of the Enovid-treated SP/SHR rose most acutely. The low protein fish diet was markedly catabolic and caused hyperlipidemia, hyperglycemia, elevated ACTH and beta-endorphin levels concomitant with reduced gonadotrophic function. Treatment with Enovid caused severe exacerbation of all of the foregoing changes. It is proposed that a low protein fish diet + 1% saline will accelerate the appearance of strokes in SP/SHR and that Enovid will enhance this effect through its anti-gonadotrophic activity and ability to stimulate increased pituitary-adrenal secretion.
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000209:etiology*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D004044:Dietary Proteins / Q000009:adverse effects*; D004723:Endorphins / Q000097:blood; D005260:Female; D005396:Fish Products; D006943:Hyperglycemia / Q000139:chemically induced; D006949:Hyperlipidemias / Q000209:etiology; D006973:Hypertension / Q000503:physiopathology; D002542:Intracranial Embolism and Thrombosis / Q000473:pathology; D008297:Male; D008656:Mestranol / Q000009:adverse effects*; D009336:Necrosis; D009641:Norethynodrel / Q000009:adverse effects*; D010296:Parietal Lobe / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin
D003277:Contraceptives, Oral, Combined; D004044:Dietary Proteins; D004723:Endorphins; D001615:beta-Endorphin; C008124:Infecundin; D009641:Norethynodrel; D000324:Adrenocorticotropic Hormone; D008656:Mestranol