[Nature of alpha receptors implicated in the hypertensive effect of high doses of isoprenaline in dogs and rats].
Isoproterenol injected intravenously in dogs (3 mg/kg-1) and rats (5 mg/kg-1) induced an increase in blood pressure. After alpha 1 blockade (by AR-C 239, 0.1 mg . kg-1 i.v.) or alpha 2 blockade (by yohimbine, 1 mg/kg-1 i.v.) isoproterenol, as adrenaline, again induced an increase in blood pressure. This hypertensive effect was suppressed by an alpha 2 adrenoceptor blocking agent after an alpha 1 adrenoceptor blocking agent, and vice versa. These results are compatible with stimulation by high doses of isoproterenol of both alpha 1 and alpha 2 adrenoceptors to produce increase in blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D005260:Female; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D010879:Piperazines; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D013268:Stimulation, Chemical; D015016:Yohimbine / Q000494:pharmacology
D007546:Isoquinolines; D010879:Piperazines; D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D007545:Isoproterenol; C032994:AR-C239
Nature des récepteurs alpha impliqués dans l'action hypertensive des fortes doses d'isoprénaline chez le chien et le rat.