Ultrastructural study of effect of ACTH4-10 on nerve regeneration; axons become larger in number and smaller in diameter.
Electron-microscopic analysis of the regenerating sciatic nerve in the rat showed that ACTH4-10 treatment stimulated the number of regenerating myelinated and unmyelinated fibers to a similar degree. Fourteen days following a crush lesion of the sciatic nerve, 23% more regenerating fibers were present in the ACTH4-10-treated group of animals. The increase in number of regenerating fibers was accompanied by a comparable decrease in axon diameter. The ACTH4-10 treatment did not change the number of lamellae in the myelin sheath.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000648:ultrastructure; D005260:Female; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000648:ultrastructure; D009412:Nerve Fibers / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000187:drug effects*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D012584:Sciatic Nerve / Q000648:ultrastructure; D013997:Time Factors
D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)