Specific receptors for calcitonin in the subfornical organ of the brain.
A radioautographic method was used to locate specific binding sites for biologically active iodinated calcitonin in rats. The results show that the subfornical organ of the brain, a suspected water regulating organ, is a specific target for calcitonin. The hormone predominantly binds to processes of tanycytes, suggesting that these ependymal cells play an intermediate role between the endocrine and nervous systems.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D051381:Rats; D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface / Q000378:metabolism*
D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface