Prostaglandins and gastrointestinal cytoprotection.
One of the important and interesting effects of prostaglandins in the gastrointestinal tract is cytoprotection: protection of the gastrointestinal mucosa against nonspecific injuries (physical, chemical, drugs, etc.). The characteristic features of cytoprotection, the possible mechanism of protection and the theoretical and clinical perspectives of prostaglandins and their analogues are discussed.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003451:Cryoprotective Agents / Q000494:pharmacology; D004068:Digestive System Physiological Phenomena; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007473:Ion Channels / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000378:metabolism
D003451:Cryoprotective Agents; D007473:Ion Channels; D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; D012964:Sodium; D011188:Potassium