title: Complete spectrum of the varicella congenital defects syndrome in 5-year-old child.
abstract: Chickenpox in the pregnant woman occasionally leads to infection and teratogenesis of the early to midgestational embryo. We describe the developmental assessment and clinical management of a 5-year-old girl with classic varicella congenital defects syndrome. This patient is unique with respect to (1) a generally favorable outcome in spite of the severity of her anomalies involving the eyes, limbs and skin, (2) a completely normal evaluation of her immunologic status and (3) a serologically documented herpes zoster infection at age 41 months.
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology* / Q000503:physiopathology; D000914:Antibodies, Viral / Q000032:analysis; D002644:Chickenpox / Q000151:congenital*; D002657:Child Development; D002675:Child, Preschool; D003165:Complement System Proteins / Q000032:analysis; D005124:Eye Abnormalities; D005260:Female; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D017880:Limb Deformities, Congenital; D008213:Lymphocyte Activation; D010587:Phagocytosis; D012868:Skin Abnormalities; D013577:Syndrome
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins; D003165:Complement System Proteins