Steric mapping of some prostaglandin receptor sites.
The Minimal Steric (Topologic) Difference method was applied to map some prostaglandin receptors. Experimental data concerning luteinizing activity of corpora lutea, and pressor respectively depressor activity on sheep blood were considered. The linear correlation coefficients obtained were r = 0.927 (N = 12) for luteinizing activity, r = 0.943 (N = 15) for depressor activity, and r = 0.943 (N = 12) for pressor activity. Similarities and differences between these three receptors are discussed.
D000495:Allosteric Site; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003338:Corpus Luteum / Q000187:drug effects / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008722:Methods; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000378:metabolism*; D012756:Sheep; D013329:Structure-Activity Relationship
D011465:Prostaglandins, Synthetic; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin