[Pharmacokinetics of ketoprofen in the synovial fluid].
Serum and synovial fluid concentrations of ketoprofen were studied after administration of 50 or 100 mg in a single oral dose to patients with rheumatoid arthritis. Results show that ketoprofen is rapidly absorbed. Serum concentrations are similar in patients and healthy subjects. During the initial phase, plasma half-life, which averaged 1.5 to 2 hours in study patients, was similar to that recorded in controls. Significant accumulation of ketoprofen in synovial fluid of patients was demonstrated.
D000284:Administration, Oral; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010666:Phenylpropionates / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism*
D010666:Phenylpropionates; D007660:Ketoprofen
Pharmacocinétique du kétoprofène dans le liquide synovial.