title: Lobster muscle and synapse respond to cortisol, a vertebrate hormone.
abstract: Cortisol (0.28 mumol X L-1) applied to lobster (Homarus americanus) neuromuscular preparations produces a hyperpolarization in muscle fibers and an increase in amplitude of excitatory postsynaptic potentials. The effect appears to be surface-mediated, because of its rapid onset (within seconds). It is also Na+-K+ ATPase dependent, because ouabain blocks the effects. The effects are relatively short-lasting, and gradually subside within 15 min. The increase in excitatory postsynaptic potentials is attributed in part to increased quantal output of transmitter, and not to changes in muscle fiber membrane resistance. The effects of cortisol on neuromuscular transmission and membrane potential indicate that cortisol may have a physiological role in crustaceans.
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D006728:Hormones / Q000502:physiology; D006854:Hydrocortisone / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D008121:Nephropidae / Q000502:physiology*; D010042:Ouabain / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013569:Synapses / Q000187:drug effects*; D014714:Vertebrates / Q000378:metabolism
chemical_list: D006728:Hormones; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D006854:Hydrocortisone