Albumin stabilizes 14,15-leukotriene A4.
14,15-Leukotriene A4 is a pivotal biosynthetic intermediate in 15-lipoxygenase initiated leukotriene biosynthesis. This compound hydrolyzes instantaneously in phosphate buffer at pH 7.4. However, addition of human or bovine albumin to otherwise identical buffer solutions increases its stability. Intact 14,15-leukotriene A4 then decomposes by first-order kinetics with rate constants inversely proportional to the albumin concentration. Stabilization of 14,15-leukotriene A4 under certain conditions may influence its proportionate transformation by enzymatic vs non-enzymatic processes.
D000818:Animals; D001095:Arachidonic Acids; D002417:Cattle; D004355:Drug Stability; D006801:Humans; D007700:Kinetics; D017572:Leukotriene A4; D012709:Serum Albumin; D012710:Serum Albumin, Bovine; D013329:Structure-Activity Relationship
D001095:Arachidonic Acids; D017572:Leukotriene A4; D012709:Serum Albumin; D012710:Serum Albumin, Bovine