[Modulation of the expression of transferrin receptors by iron, hemin and protoporphyrin IX].
The expression of transferrin receptors in human leukemic cell lines was investigated. Our results have clearly shown that heme, iron and protoporphyrin-IX may modulate the expression of Trf receptors: iron and heme induce a decrease in the number of Trf receptors; in contrast protoporphyrin-IX elicited a significant increase in the number of Trf receptors. On the basis of these data we suggest that the intracellular concentration of iron, heme and protoporphyrin-IX may represent the main factor involved in the regulation of the expression of Trf receptors.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D006418:Heme / Q000031:analogs & derivatives*; D006427:Hemin / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007501:Iron / Q000378:metabolism* / Q000494:pharmacology; D007938:Leukemia / Q000097:blood; D011166:Porphyrins / Q000378:metabolism*; D011524:Protoporphyrins / Q000378:metabolism* / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011990:Receptors, Transferrin
D011166:Porphyrins; D011524:Protoporphyrins; D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D006418:Heme; D006427:Hemin; C028025:protoporphyrin IX; D007501:Iron
Modulation de l'expression des récepteurs de la transferrine par le fer, l'héme et la protoporphyrine-IX.