title: [Side effects of ketoconazole].
abstract: Ketoconazole, a new orally active broad-spectrum antimycotic, is usually well tolerated. Liver changes have been observed with an incidence rate below 1:10 000; they are idiosyncratic reactions independent from duration of treatment or dosage. Ketoconazole given in a dosage of 400 mg daily or more may inhibit testosterone biosynthesis.
mesh_terms: D000368:Aged; D004305:Dose-Response Relationship, Drug; D004702:Endocrine Glands / Q000187:drug effects; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy*; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D007654:Ketoconazole
vernacular_title: Zum Problem der Ketoconazolnebenwirkungen.