[Effect of anesthesia on blood concentration of cyclic nucleotides and their role in the metabolism of humoral mediators in the lungs].
The contents of cAMP and cGMP, adrenaline, noradrenaline and serotonin in the blood were studied in 96 patients with surgical pathology of lungs. Anesthesia and intraoperative factors were shown to result in a gradual increase of the cAMP concentration followed by the histamine release from the pulmonary tissue. It is associated with an increased pulmonary-arterial and pulmonary-capillary pressure when getting out of narcosis and in the restoration of spontaneous respiration.
D000293:Adolescent; D000328:Adult; D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D002395:Catecholamines / Q000097:blood; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D006632:Histamine / Q000097:blood; D006801:Humans; D008168:Lung / Q000378:metabolism; D008171:Lung Diseases / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D011013:Pneumonectomy; D011184:Postoperative Period; D011453:Prostaglandins / Q000097:blood; D011652:Pulmonary Circulation; D012701:Serotonin / Q000097:blood
D002395:Catecholamines; D011453:Prostaglandins; D012701:Serotonin; D006632:Histamine; D000242:Cyclic AMP; D006152:Cyclic GMP
Vliianie anestezii na kontsentratsiiu tsiklicheskikh nukleotidov v krovi i ikh rol' v metabolizme gumoral'nykh mediatorov v legkikh.