Moderate grade astrocytoma presenting in a 4-month-old child with a family history of von Recklinghausen's neurofibromatosis spanning four generations: a case report.
Intracranial gliomas are found in association with von Recklinghausen's neurofibromatosis. However, few truly neonatal lesions have been identified and studied. This case report concerns a 4-month-old child who was found to have a massive thalamic glioma of moderate grade. Four paternal generations had suffered from different manifestations of this transmissible autosomal-dominant (Ad) phakomatosis.
D000328:Adult; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000235:genetics; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000235:genetics; D005910:Glioma / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D009456:Neurofibromatosis 1 / Q000000981:diagnostic imaging / Q000235:genetics*; D010375:Pedigree; D013788:Thalamus / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed