Pharmacokinetics of sulbactam and ampicillin following oral administration of sultamicillin with probenecid.
Eight volunteers each received lg of probenecid followed immediately by 1.5 g sultamicillin, both given by the oral route. Plasma concentrations of ampicillin and sulbactam were measured using a differential bioassay method. An ampicillin mean peak plasma concentration of 23.1 mg/l was found typically 1.5 h after dosing; the mean peak plasma concentration of sulbactam (10.0 mg/l) occurred at the same time. The mean plasma half-life of ampicillin was 1.45 h and that of sulbactam 1.3 h. The mean urinary recovery of ampicillin was 65% and that of sulbactam 62%. Five of the volunteers reported minor changes in bowel habits.
D000284:Administration, Oral; D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism* / Q000652:urine; D001682:Biological Availability; D055598:Chemical Phenomena; D002621:Chemistry; D004338:Drug Combinations / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism* / Q000652:urine; D010403:Penicillin Resistance; D011339:Probenecid / Q000008:administration & dosage / Q000378:metabolism*; D013407:Sulbactam
D004338:Drug Combinations; C035444:sultamicillin; D000667:Ampicillin; D010397:Penicillanic Acid; D011339:Probenecid; D013407:Sulbactam