title: The nucleotide sequence of poliovirus type 3 leon 12 a1b: comparison with poliovirus type 1.
abstract: The complete nucleotide sequence of the genome of the Sabin vaccine strain of poliovirus type 3 (P3/Leon 12 a1 b) has been determined from cDNA cloned in E. coli. The genome comprises a 5' non-coding region of 742 nucleotides, a large open reading frame of 6618 nucleotides (89% of the sequence) and a 3' non-coding region of 72 nucleotides. There is 77.4% base-sequence homology and 89.6% predicted amino-acid homology between types 1 and 3. Conservation of all glutamine-glycine and tyrosine-glycine cleavage sites suggests a mechanism of polyprotein processing similar to that established for poliovirus type 1.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis*; D005796:Genes; D005814:Genes, Viral; D017955:Poliovirus / Q000235:genetics*; D011055:Poliovirus Vaccine, Oral; D013045:Species Specificity
chemical_list: D011055:Poliovirus Vaccine, Oral; D004247:DNA