Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man.
The effect of guar gum on the absorption of digoxin and phenoxymethyl penicillin was studied in a double blind study in 10 healthy volunteers. Guar gum reduced serum digoxin concentration during the early absorption period, but a similar amount of digoxin was found in 24 h urine whether given with or without guar gum. Both the peak penicillin concentration and the area under the serum curve were significantly reduced by the gum.
D000328:Adult; D004043:Dietary Fiber / Q000494:pharmacology*; D004077:Digoxin / Q000378:metabolism*; D004311:Double-Blind Method; D005260:Female; D005685:Galactans / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008351:Mannans / Q000494:pharmacology*; D010404:Penicillin V / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism*; D053149:Plant Gums
D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D010406:Penicillins; D053149:Plant Gums; D004077:Digoxin; C007894:guar gum; D010404:Penicillin V