[Effect of opioid peptides on the transmission of nociceptive excitation in the spinal cord afferent tracts].
The effects of methionine-enkephalin, leucine-enkephalin and of their two synthetic analogs on nociceptive transmission in the afferent tract of the spinal cord were studied in anesthetized spinal rats. All the opioid peptides inhibited the bradykinin-induced discharges in axons of the ventrolateral tract. However, the preparations had dissimilar effects on spontaneous activity. Naloxone blocked the action of the opioids.
D000200:Action Potentials / Q000187:drug effects; D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004723:Endorphins / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D004723:Endorphins; D009270:Naloxone; D001920:Bradykinin
Vliianie opiatnykh peptidov na peredachu notsitseptivnogo vozbuzhdeniia v afferentnykh traktakh spinnogo mozga.