[A case of icterus during treatment with triacetyloleoandomycin as sole therapy].
A case of jaundice is reported, which was eventually ascribed to TAO alone, once infectious, viral, neoplastic . . . causes were outruled. For specific reasons, high doses of this antibiotic had been required. The physiopathology is discussed; allergy is dismissed. The product's hepatotoxicity in high doses is considered. Although pathological evidence is lacking, this hypothesis is supported by the occurrence of rapid and complete resolution once therapy was discontinued. Specific characteristics of the jaundice are also pointed out: mildness and occurrence after a long interval. This brief paper is by no means designed to disparage TAO, but is meant to monitor, as far as possible, its dosage.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007565:Jaundice / Q000139:chemically induced* / Q000175:diagnosis; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D014217:Troleandomycin / Q000008:administration & dosage / Q000009:adverse effects*; D014946:Wound Infection / Q000188:drug therapy
D014217:Troleandomycin
Sur un cas d'ictère survenu au cours d'un traitement au seul tri-acétyl-oléandomycine.