title: [ACTH-altered adrenal cortical uptake of the radioiodinated 11 beta-hydroxylase inhibitor (L)-SKF 12185].
abstract: (L)-SKF 12185, a reversible inhibitor of the enzyme 11 beta-hydroxylase, can, if radioiodinated, be used for the scintigraphic imaging of the adrenal cortex. An increased uptake of 131I-(L)-SKF 12185 was observed therein 2-3 hrs after ACTH stimulation. This effect can be explained by the steroid neogenesis induced by ACTH stimulation and the activation of the required enzymes connected therewith. The inhibitor attaches competitively with the relevant substrates to the free enzyme binding sites and produces an enhanced adrenal uptake. Thus ACTH stimulation increased the 3 hr uptake by 69% whereas the 24 hr uptake which, because of its relatively high adrenal/liver ratio, is more useful in the scintigraphic imaging of the adrenals, could not be improved significantly.
mesh_terms: D000302:Adrenal Cortex / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D007457:Iodine Radioisotopes / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D010627:Phenethylamines / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D013252:Steroid 11-beta-Hydroxylase / Q000037:antagonists & inhibitors*; D013250:Steroid Hydroxylases / Q000037:antagonists & inhibitors*; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D010627:Phenethylamines; C006221:2-(4-aminophenyl)-2-phenethylamine; D000324:Adrenocorticotropic Hormone; D013250:Steroid Hydroxylases; D013252:Steroid 11-beta-Hydroxylase
vernacular_title: ACTH-alterierte Nebennierenrindenanreicherung des radiojodierten 11 beta-Hydroxylaseinhibitors (L)-SKF 12185.