Penetration of sulbactam and ampicillin into peritoneal fluid.
Twenty-five patients undergoing elective intraabdominal surgery received either 1 or 2 g of ampicillin together with 1 g of sulbactam intravenously before surgery. The peritoneal levels of the agent were measured. Both compounds penetrated peritoneal fluid readily; the mean percentage of penetration by ampicillin was 92%; that of sulbactam was 96%. After 1 g of each agent, the peritoneal levels of sulbactam were 47% greater than those of ampicillin. Our results suggest that 2 g of ampicillin plus 1 g of sulbactam should provide peritoneal levels that would inhibit most susceptible beta-lactamase-producing pathogens encountered in intraabdominal sepsis.
D000368:Aged; D000667:Ampicillin / Q000378:metabolism* / Q000494:pharmacology; D001202:Ascitic Fluid / Q000378:metabolism*; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D010397:Penicillanic Acid / Q000378:metabolism* / Q000494:pharmacology; D013407:Sulbactam; D065093:beta-Lactamase Inhibitors
D065093:beta-Lactamase Inhibitors; D000667:Ampicillin; D010397:Penicillanic Acid; D013407:Sulbactam