On the mechanism of spiking and bursting in excitable cells.
A mathematical model previously developed to explain beta-cell membrane potential oscillations has been modified to accommodate the external variation of K+, Na+ and Ca2+ concentrations. Our model, which is applicable to excitable cells, incorporates the barrier kinetics. Hodgkin-Huxley-type gating mechanism, and an electrogenic Na+-K+ pump. Numerical solutions of our model are in agreement with many of the experimental results reported in the literature on excitable cells.
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism; D007473:Ion Channels / Q000502:physiology*; D007515:Islets of Langerhans / Q000502:physiology*; D008433:Mathematics; D008564:Membrane Potentials; D008954:Models, Biological; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D007473:Ion Channels; D012964:Sodium; D011188:Potassium; D002118:Calcium