Lack of enhanced mutation of UV- and gamma-irradiated herpes virus in UV-irradiated CV-1 monkey cells.
The frequency of forward mutation of unirradiated, UV-irradiated or gamma-irradiated herpes virus was determined after infecting UV-irradiated or unirradiated CV-1 monkey kidney cells, to investigate the correlation between UV-enhanced reactivation (UVER) and mutagenesis. UV-irradiation to cells had no effect on mutation frequency of irradiated virus even in the conditions in which UVER was maximally expressed for the survival of UV-irradiated virus.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral / Q000528:radiation effects*; D002522:Chlorocebus aethiops; D005720:Gamma Rays; D007668:Kidney; D009154:Mutation; D018139:Simplexvirus / Q000528:radiation effects*; D014466:Ultraviolet Rays