Complex action of antidepressant treatment on central adrenergic system: possible relevance to clinical effects.
Chronic antidepressant treatment with classical and atypical antidepressant drugs and ECT leads to complex changes in the central adrenergic system, consisting of upregulation of alpha 1 and downregulation of alpha 2 and beta adrenoceptors. These changes may lead to a specific facilitation of neurotransmission in structures employing alpha 1 adrenoceptors, involved in the control of mood and emotions.
D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D004565:Electroconvulsive Therapy; D006801:Humans; D007700:Kinetics; D011941:Receptors, Adrenergic / Q000187:drug effects; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D000928:Antidepressive Agents; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D000242:Cyclic AMP