[Hormone-dependent enhancement of malignant phenotype in cells infected with mouse mammary tumor virus (MMTV), and role of antigen transduction in this process].
Mouse mammary tumor virus (MMTV) is known to infect heterologous cells but it does not appear that it alters their growth or morphological characteristics. Djungarian hamster mammary tumor cells infected with MMTV were found to increase the ability of the above cells to grow in semi-solid media. This effect was demonstrable only in the presence of insulin and dexamethasone in cultural media. Meanwhile non-infected cells were discovered to show no responsiveness to hormones. The expression of non-viral antigen revealed by allogeneic anti-Thy 1.2 on the surface of infected cells was shown by the use of the cytotoxic test and immunofluorescence technique. However, the use of monoclonal anti-Thy 1.2 antibodies failed to prove that antigen in question was structural virion protein or Thy 1.2 antigen.
D000818:Animals; D000941:Antigens / Q000235:genetics*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D003907:Dexamethasone / Q000276:immunology*; D007328:Insulin / Q000276:immunology*; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D010641:Phenotype; D014161:Transduction, Genetic
D000941:Antigens; D007328:Insulin; D003907:Dexamethasone
Gormonozavisimoe povyshenie opukholevogo fenotipa kletok, zarazhennykh virusom raka molochnoĭ zhelezy myshei (MMTV), i rol' v étom protsesse transdutsiruemykh im antigenov.