[Change in cerebral microcirculation at long-term periods following irradiation with protection by gammaphos].
A study was made of the influence of prophylactic administration of gammaphos (300 mg/kg) on radiation alterations in the system of cerebral microcirculation of rats in a long-term period following local irradiation of doses of 40-60 Gy. It has been shown that the number of animals with severe vascular injuries and the degree of these injuries lessen. A computerized analysis has shown that gammaphos administration weakens a decrease in the mean number of vessels and an increase in their average size caused by irradiation.
D004999:Amifostine / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000098:blood supply*; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects; D009946:Organothiophosphorus Compounds / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009946:Organothiophosphorus Compounds; D011837:Radiation-Protective Agents; D004999:Amifostine
Izmenenie mikrotsirkuliatsii v golovnom mozge v otdalennye sroki posle oblucheniia v usloviiakh zashchity gammafosom.