CAPP-calmodulin: a potent competitive inhibitor of calmodulin actions.
A covalent adduct of norchlorpromazine (CAPP) and calmodulin is a very potent antagonist of calmodulin activation of several enzymes. The phenothiazine-calmodulin complex (CAPP-calmodulin) acts as a pure antagonist with phosphodiesterase and myosin kinase or a partial agonist with the phosphoprotein phosphatase, calcineurin. Because of its potency and the selectivity inherent to its calmodulin moiety, CAPP-calmodulin should be a uniquely useful probe of calmodulin actions.
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D002147:Calmodulin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D002148:Calmodulin-Binding Proteins; D002645:Chickens; D002746:Chlorpromazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D008297:Male; D009219:Myosin-Light-Chain Kinase; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D012756:Sheep; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D002148:Calmodulin-Binding Proteins; C040306:norchlorpromazine-calmodulin complex; D014268:Trifluoperazine; D011494:Protein Kinases; D009219:Myosin-Light-Chain Kinase; D010749:Phosphoprotein Phosphatases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D002746:Chlorpromazine