Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of normal and anemic subjects.
Red cell phosphoglycolate phosphatase (PGP) and 2,3-diphosphoglycerate (2,3-DPG) were investigated in normal and anemic patients and rabbits. In hemolytic anemia and blood-loss anemia, characterized by a young red cell population, there was an increase in both phosphoglycolate phosphatase activity and 2,3-diphosphoglycerate levels. In aplastic anemia, the phosphoglycolate phosphatase activity was normal, but the 2,3-diphosphoglycerate values were nonetheless increased. Thus, no relationship was found between phosphoglycolate phosphatase activity and 2,3-diphosphoglycerate levels. The lack of correlation between the activity of phosphoglycolate phosphatase and 2,3-DPG levels suggests that modulation of phosphoglycolate phosphatase activity does not control the level of 2,3-DPG in erythrocytes.
D019794:2,3-Diphosphoglycerate; D000328:Adult; D000740:Anemia / Q000097:blood / Q000201:enzymology*; D000741:Anemia, Aplastic / Q000097:blood / Q000201:enzymology; D000743:Anemia, Hemolytic / Q000097:blood / Q000201:enzymology; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis / Q000201:enzymology*; D006452:Hemoglobinometry; D006801:Humans; D010744:Phosphoric Monoester Hydrolases / Q000097:blood*; D011817:Rabbits; D012156:Reticulocytes
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; C022408:phosphoglycolate phosphatase; D010744:Phosphoric Monoester Hydrolases