17-beta-estradiol levels in patients with small cell carcinoma of the lung.
Human SCCL cell lines produce 17-beta-estradiol (E2) in all cases that we have studied. In order to determine whether this phenomenon has a clinical counterpart, we analyzed sera from 25 consecutive patients with newly diagnosed, untreated SCCL for E2. We found serum E2 concentrations in all patients to be within the normal range. This discrepancy between cell culture and patient-derived data emphasizes yet another dichotomy between in vivo and in vitro observations.
D018288:Carcinoma, Small Cell / Q000097:blood* / Q000378:metabolism; D002460:Cell Line; D004958:Estradiol / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000378:metabolism
D004958:Estradiol