Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells.
The antigrowth effects of 5 different cloned human leukocyte IFN subtypes (IFN-alpha A, B, C, D, F) and 2 molecular hybrids between them (IFN-alpha AD(Bg1II) and IFN-alpha DA(Bg1II)) were examined on 6 different human cell lines. The results indicate that the interferons sort into two distinct groups: IFN-alpha B, C and F showed comparable antiproliferative activity which was greater than that of IFN-alpha A, D, AD(Bg1II) and DA(Bg1II). The interferons could also be assigned to one of two groups on the basis of their antiviral activity. IFN-alpha A, D and AD(Bg1II) were observed to be more protective than IFN-alpha B, C and F against HSV-2 and EMCV infections, i.e. the relative antiviral efficacies of the cloned IFN subtypes were the reverse of their antiproliferative activities.
D000998:Antiviral Agents; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004686:Encephalomyocarditis virus / Q000187:drug effects; D006131:Growth Inhibitors; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; D006131:Growth Inhibitors; D007370:Interferon Type I