[Oncogene expression and cell transformation].
Recent studies on transforming genes of retroviruses have revealed that these viral transforming genes (v-onc) were derived from prototype genes (c-onc) present in normal cells. These c-onc genes are believed to carry out some unknown but important functions for cells to proliferate or differentiate. As a plausible mechanism of carcinogenesis it has been proposed that cells in which one of these onc genes happen to be expressed to abnormal extent as a result of mutations in controlling elements or as a result of infection with viruses containing these genes would become cancerous. In this article, the common features of products of genetically different viral onc genes found in avian sarcoma viruses and their cellular onc genes are described. Experiments of recovered ASV suggesting close relationship between viral and cellular genes and studies on mechanism of cell transformation by these viral gene products are also presented.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D005814:Genes, Viral; D051379:Mice; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000302:isolation & purification; D009857:Oncogenes; D011494:Protein Kinases / Q000378:metabolism; D011506:Proteins / Q000302:isolation & purification; D051381:Rats; D014443:Tyrosine / Q000378:metabolism
D009363:Neoplasm Proteins; D011506:Proteins; D014443:Tyrosine; D011494:Protein Kinases