Prognostic significance of herpes simplex virus antibody status in women with cervical intraepithelial neoplasia (CIN).
A total of 107 women with abnormal cervical smears showing cytological changes consistent with cervical intraepithelial neoplasia (CIN) 1 or CIN 2 were kept under regular cytological, colposcopic, virological and serological surveillance for an average of 18 months (range 9 months-3 years). Regression of the cervical lesion was noted in 31 (29%) and progression to CIN 3 in nine women (8.4%). We found a positive correlation between the presence of type 2 antibody and progression of CIN 1 and 2 to CIN 3 and a negative association with the presence of type 1 antibody and suggest the antibody status of a woman with CIN 1 or CIN 2 may provide a useful basis for follow-up. We found no association between the outcome of the cervical lesion and active infection with herpes simplex or cytomegalovirus or any other infectious agent or sex-related factors.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D003168:Complement Fixation Tests; D003586:Cytomegalovirus Infections / Q000150:complications; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006561:Herpes Simplex / Q000150:complications; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011379:Prognosis; D018139:Simplexvirus / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000276:immunology* / Q000473:pathology; D014626:Vaginal Smears
D000914:Antibodies, Viral