Stimulation of cell proliferation by vitamin A derivatives on murine sarcoma virus-transformed mouse cells in serum-free culture.
The effect of retinoids (Rds) on cell proliferation was studied in serum-free culture condition, using non-transformed and transformed derivatives of BALB 3T3. Cell proliferation of an SV40-transformed line was inhibited significantly by Rd treatment. However, proliferation of two cell lines that were transformed by a Kirsten and Moloney strain of murine sarcoma virus (MSV) and produced growth factor into culture medium, was remarkably stimulated by Rds. Addition of serum masked both the inhibitory and stimulatory effects of Rds.
D000818:Animals; D001769:Blood; D002460:Cell Line; D002472:Cell Transformation, Viral; D003470:Culture Media; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D006133:Growth Substances / Q000096:biosynthesis / Q000494:pharmacology; D007708:Kirsten murine sarcoma virus / Q000502:physiology; D051379:Mice; D012172:Retinaldehyde / Q000494:pharmacology; D000084562:Retinyl Esters; D009053:Sarcoma Viruses, Murine / Q000502:physiology*; D013539:Simian virus 40 / Q000502:physiology; D014212:Tretinoin / Q000494:pharmacology; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology*
D003470:Culture Media; D004224:Diterpenes; D006133:Growth Substances; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D014212:Tretinoin; D012172:Retinaldehyde