Candidate products of avian myeloblastosis virus oncogene region produced by in vitro translation of genomic RNA.
Avian myeloblastosis virus (AMV) genomic RNA was translated in vitro to identify the AMV transforming gene (myb) product(s). Full-length RNA yielded, in addition to the expected Pr76gag, a gag-related product of 92,000 daltons which did not appear to be a gag-oncogene fusion protein. Subgenomic AMV RNA in vitro translation, nonstructural products (specific for AMV) were of 54,000, 49,000 and 34,000 daltons. Based on their sizes and similar peptide maps for the smaller two proteins, it is proposed that they derive from the myb region of AMV.
D001354:Avian Leukosis Virus / Q000235:genetics*; D009189:Avian Myeloblastosis Virus / Q000235:genetics*; D002472:Cell Transformation, Viral; D005814:Genes, Viral; D008970:Molecular Weight; D009857:Oncogenes; D010446:Peptide Fragments / Q000032:analysis; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
D010446:Peptide Fragments; D012367:RNA, Viral; D014764:Viral Proteins