[Concentrations of cefotiam in serum, heart valves, muscle and adipose tissue during heart surgery].
In 20 patients undergoing heart surgery, concentrations of cefotiam (Halospor) in plasma, heart valves, muscles and subcutaneous tissue were determined after intravenous injection of 2 g. Within 5 h cefotiam serum concentration declined from 18 micrograms/ml to 7 micrograms/ml, the concentrations in heart valves declined from 22 micrograms/g to 4 micrograms/g. In heart valves the concentrations during heart surgery were high enough to inhibit most Staphylococcus aureus, E. coli and Klebsiella strains.
D000273:Adipose Tissue / Q000378:metabolism*; D006348:Cardiac Surgical Procedures; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D015310:Cefotiam; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006351:Heart Valves / Q000378:metabolism*; D006801:Humans; D007709:Klebsiella / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011292:Premedication; D013210:Staphylococcus / Q000187:drug effects; D013997:Time Factors
D015310:Cefotiam; D002439:Cefotaxime
Konzentrationen von Cefotiam in Serum, Herzklappen, Muskel- und Fettgewebe während herzchirurgischer Eingriffe.