[Aminomethylol compounds inhibit the initiation of RNA chain synthesis beginning with adenylic nucleotides].
It was found that the previously established inhibition of DNA transcription in vitro caused by aminomethylol compounds depends on the suppression of the RNA chains initiation beginning with adenylic but not with guanylic acid. The RNA polymerase binding to DNA is not impaired thereby; the enzyme affinity for the binding sites and RNA elongation also remain unaffected. A comparison of aminomethylol compounds with other alkylating agents demonstrated that the former are the only known alkylating compounds which specifically influence the initiation step. The nature of DNA structural changes (initiation inhibition) caused by aminomethylol compounds is discussed.
D000227:Adenine Nucleotides; D002460:Cell Line; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D005557:Formaldehyde / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology*; D007700:Kinetics; D013539:Simian virus 40 / Q000235:genetics; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects*
D000227:Adenine Nucleotides; D005557:Formaldehyde; D012321:DNA-Directed RNA Polymerases; D005998:Glycine
Aminometilol'nye soedineniia ingibiruiut initsiatsiiu sinteza tsepeĭ RNK, nachinaiushchikhsia s adenilovykh nukleotidov.