Modification of single sodium channels by the insecticide tetramethrin.
(+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.
D000818:Animals; D001496:Batrachotoxins / Q000494:pharmacology; D002460:Cell Line; D007473:Ion Channels / Q000187:drug effects*; D051379:Mice; D009447:Neuroblastoma; D011722:Pyrethrins / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*
D001496:Batrachotoxins; D007473:Ion Channels; D011722:Pyrethrins; D012964:Sodium; C009424:tetramethrin