Phorbol ester receptors and the in vitro effects of tumor promoters.
The evidence for the multistage nature of tumor promotion in vivo and for multiple subclasses of phorbol ester receptors in vitro argues that multiple mechanisms of tumor promotion exist. The existence of multiple mechanisms suggests that brute force assay for tumor promoters in vivo may be inadequate and that understanding of mechanisms may be essential. The interest in the phorbol esters is not primarily that they are environmental hazards for man, but rather that they provide a probe for phorbol ester receptors. These receptors are found in people, and modulation of their activity may play a role in tumor promotion in man.
D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000378:metabolism / Q000633:toxicity*; D010704:Phorbols / Q000633:toxicity*; D011493:Protein Kinase C; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000502:physiology; D011955:Receptors, Drug; D012878:Skin Neoplasms / Q000139:chemically induced*; D013329:Structure-Activity Relationship
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D010703:Phorbol Esters; D010704:Phorbols; D011956:Receptors, Cell Surface; D011955:Receptors, Drug; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C