Imaging of inflammatory processes with labeled cells.
Radionuclide techniques for localizing inflammatory processes had relied heavily upon 67Ga-citrate until McAfee and Thakur described the technique for the radiolabeling of leukocytes with 111In-oxine. Since their initial description in 1976 there has been continued development of the radiopharmaceutical, as well as clinical efficacy. At present 111In-labeled leukocytes continue to be handled as an investigational new drug but this has not greatly limited its clinical availability. Indium-111 leukocytes are the agent of choice for evaluation of patients with fever of unknown origin, osteomyelitis, and prosthetic graft infections; and preliminary data shows great promise in the area of detecting reoccurrence of inflammatory bowel disease. This article attempts to review currently accepted uses of 111In leukocytes as well as potential areas of application.
D000038:Abscess / Q000000981:diagnostic imaging; D001807:Blood Vessel Prosthesis; D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging; D003424:Crohn Disease / Q000000981:diagnostic imaging; D003586:Cytomegalovirus Infections / Q000000981:diagnostic imaging; D004761:Enterocolitis, Pseudomembranous / Q000000981:diagnostic imaging; D005335:Fever of Unknown Origin / Q000000981:diagnostic imaging; D005710:Gallium Radioisotopes; D006801:Humans; D007204:Indium; D007239:Infections / Q000000981:diagnostic imaging; D007249:Inflammation / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008100:Liver Abscess / Q000000981:diagnostic imaging; D009942:Organometallic Compounds; D010019:Osteomyelitis / Q000000981:diagnostic imaging; D015125:Oxyquinoline / Q000031:analogs & derivatives; D010182:Pancreatic Diseases / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging
D005710:Gallium Radioisotopes; D009942:Organometallic Compounds; D007204:Indium; C032950:indium oxine; D015125:Oxyquinoline