title: The role of antidepressants in the treatment of affective disorders.
abstract: The paper reviews studies of the effectiveness of antidepressants in acute depression and variables accounting for nonresponsiveness. Data supporting continuation and maintenance therapy are presented. The authors discuss nonspecific psychotherapeutic components of drug management and also review studies of the usefulness of antidepressant and psychotherapy, alone and in combination.
mesh_terms: D000639:Amitriptyline / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000188:drug therapy* / Q000628:therapy; D004311:Double-Blind Method; D006321:Heart / Q000187:drug effects; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D009638:Norepinephrine / Q000378:metabolism; D010919:Placebos; D011613:Psychotherapy; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D010919:Placebos; D017981:Receptors, Neurotransmitter; D000639:Amitriptyline; D007099:Imipramine; D009638:Norepinephrine