Localization of thyrotropin-releasing hormone (TRH) receptors in the septal nucleus of the rat brain.
[3H](3MeHis2)TRH binding was examined in the septal nucleus of rats given brain lesions which destroyed specific neuronal elements within the septum. Kainic acid injected directly into the septum caused a 35% decrease in receptor binding. All other lesions did not significantly alter receptor binding. These data suggest that the septal TRH receptors are located on kainic acid-sensitive cell bodies.
D000344:Afferent Pathways / Q000378:metabolism; D000818:Animals; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018025:Receptors, Thyrotropin-Releasing Hormone; D012686:Septal Nuclei / Q000378:metabolism*; D009435:Synaptic Transmission; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
D011956:Receptors, Cell Surface; D018025:Receptors, Thyrotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone