[Comparative testing of the quality of foot-and-mouth disease vaccines prepared with different virus inactivators].
Formalin, glycidaldehyde, and the binary ethyleneimine were tested under laboratory conditions as inactivators of the foot-and-mouth disease virus along with the possibility of using them in the process of vaccine production. Data is presented on the comparative testing for innocuity and immunogenicity for sheep of F. M. D. vaccines produced with such inactivators. Results showed the advantages of the binary ethyleneimine as against formalin and glycidaldehyde as an inactivator of the F. M. D. virus.
D000447:Aldehydes / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000276:immunology*; D005537:Aphthovirus / Q000276:immunology*; D001388:Aziridines / Q000276:immunology; D002986:Clinical Trials as Topic / Q000662:veterinary; D004852:Epoxy Compounds / Q000276:immunology; D005557:Formaldehyde / Q000276:immunology; D011786:Quality Control; D012756:Sheep; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000447:Aldehydes; D000914:Antibodies, Viral; D000998:Antiviral Agents; D001388:Aziridines; D004852:Epoxy Compounds; D014613:Vaccines, Attenuated; D014765:Viral Vaccines; D005557:Formaldehyde; C033132:aziridine; C007871:glycinaldehyde
Sravnitelno izpitvane kachestvata na protivoshapni vaksini, prigotveni c razlichni inaktivatori na virusa.