[Effect of GABA-ergic substances on the elaboration of conditioned reflexes in rats under negative reinforcement].
Experiments on female rats have shown that gabalid (100 and 200 mg/kg) does not essentially change the formation of the conditioned reflexes in intact animals and in those with an involved caudate nucleus whereas cainic acid injected intraperitoneally (15 mg/kg) and applied to the caudate nucleus deteriorates and when given in a dose of 5 mg/kg improves the formation of the conditioned reflexes. Baclofen (10 mg/kg) inhibits the conditioned reflexes in both intact animals and in those with an involved caudate nucleus, whereas in a dose of 1 mg/kg the drug improves it in intact animals and inhibits it in animals with impaired function of the caudate nucleus. The importance of the GABA-ergic system of the caudate nucleus for the action of GABA-ergic agents on the conditioned reflexes in rats is discussed.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D002421:Caudate Nucleus / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005260:Female; D007608:Kainic Acid / Q000494:pharmacology; D010775:Photic Stimulation; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011963:Receptors, GABA-A; D012054:Reinforcement, Psychology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C036611:gabalid; D001418:Baclofen; D007608:Kainic Acid; D010889:Piracetam
Vliianie GAMK-ergicheskikh veshchestv na vyrabotku uslovnykh refleksov u krys pri otritsatel'nom podkreplenii.