[Interaction between thyrotropin and prostaglandins E and plasma membranes of human isolated thyrocytes].
Thyrotropin (TTH) and prostaglandin E2 (PGE2) interaction was studied, using the euthyroid paranodal tissue (isolated by sub-surgery) of the thyroid in patients with nodose goiter. Two types of specific binding, differing by the affinity and ligand-bound capacity, were discovered both for TTH and PGE2. The appropriate kinetic characteristics were analysed. The data concerning a possible PGE2 receptor localization on the external side of the thyrocyte plasma membrane were obtained by means of affinity chromatography. A precise relationship between specific TTH-PGE2 binding and human thyroid cells was revealed.
D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D011458:Prostaglandins E / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000378:metabolism*; D013961:Thyroid Gland / Q000648:ultrastructure*; D013972:Thyrotropin / Q000378:metabolism*
D011458:Prostaglandins E; D011956:Receptors, Cell Surface; D011982:Receptors, Prostaglandin; D013972:Thyrotropin
Vzaimodeĭstvie tirotropina i prostaglandinov gruppy E s plazmaticheskimi membranami izolirovannykh tireotsitov cheloveka.