Long-term reduction in beta-adrenergic receptor binding after amygdala kindling in rats.
The long-term effect of amygdala kindling on beta-adrenergic receptor binding was examined in three groups of Wistar rats. The animals in one of two kindled groups received six stage-5 generalized convulsions, one each day, and then were not stimulated for 23 days before being killed (23-day group). Animals in the other kindled group received only five generalized convulsions prior to 22 days of no stimulation but then received their sixth convulsion 1 day before being killed (1-day group). All animals including the operated controls experienced similar handling. A significant reduction in [3H]dihydroalprenolol binding in the anterior cortex and kindled amygdala was observed in the 23-day animals compared with control animals, whereas the 1-day animals exhibited intermediate values which were not different from either of the other two groups. Thus, amygdala kindling results in a long-lasting reduction in beta-adrenergic binding which, paradoxically, can be partially ameliorated by a single convulsion 1 day before killing.
D000679:Amygdala / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine