title: Localization of the polymorphic human calcitonin gene on chromosome 11.
abstract: A molecular probe containing a 584 base pairs sequence corresponding to part of the human calcitonin mRNA was used for the chromosomal assignment of the calcitonin gene. Restriction endonuclease analysis of DNA from human-Chinese hamster and human-mouse somatic cell hybrids, including some containing a translocation of human chromosomes, placed the calcitonin gene in the p14----qter region of chromosome 11. Analysis of human DNA showed that the calcitonin gene has a polymorphic site for restriction endonuclease TaqI.
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000032:analysis / Q000235:genetics*; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004262:DNA Restriction Enzymes; D005260:Female; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D010375:Pedigree; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D002116:Calcitonin; D004262:DNA Restriction Enzymes