[Effect of high and superhigh doses of 60Co gamma-quanta and fission neutrons on rats].
A transient form of acute radiation sickness could be distinguished in Wistar rats after total-body exposure to 60Co-gamma-rays in high doses (150-200 Gy). With local exposure of head, in addition to direct damaging effect on the nervous system, the organismic factors play an important role in the development of the CNS syndrome. Effects of fractionation of superhigh doses of gamma-quanta and fission neutrons were not observed. The RBE of neutrons should constitute 1.8 for the transient form of radiation sickness to develop. This value is much lesser than that needed for the development of haemopoietic and intestinal lesions. PAPP, "gammaphos" and the combination of these agents do not influence the affection of rats by high doses of gamma-quanta.
D004999:Amifostine / Q000627:therapeutic use; D000818:Animals; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D009502:Neutrons; D011427:Propiophenones / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000401:mortality* / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012062:Relative Biological Effectiveness
D003037:Cobalt Radioisotopes; D011427:Propiophenones; D011837:Radiation-Protective Agents; C029564:4-aminopropiophenone; D004999:Amifostine
Deĭstvie vysokikh i sverkhvysokikh doz gamma-kvantov 60Co i neĭtronov deleniia na krys.