Hyperpolarization following long-lasting tetanic activation of hippocampal pyramidal cells.
Long-lasting spike activation of CA3 hippocampal pyramidal neurons is shown to cause the development of a large and long-lasting (greater than 50 s) membrane hyperpolarization (PTH). Under normal conditions this PTH is mainly given by a relatively potential-independent process, presumably an electrogenic sodium pump. Following reduction in pump activity (cooling, ouabain), the PTH remains but is mainly produced by a conductance process, presumably a K conductance increase resulting from a sodium-induced calcium release from intracellular stores.
D000200:Action Potentials; D000818:Animals; D002463:Cell Membrane Permeability; D006168:Guinea Pigs; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission; D013779:Tetrodotoxin / Q000494:pharmacology
D007473:Ion Channels; D013779:Tetrodotoxin; D010042:Ouabain; D011188:Potassium