Synergistic activity of cefsulodin combined with cefoxitin and sulbactam against Bacteroides species.
The in-vitro activity of cefsulodin combined with sulbactam, cefoxitin or cefotaxime was investigated against 32 strains of beta-lactamase-producing Bacteroides species. Synergy of cefsulodin-sulbactam or cefsulodin-cefoxitin could be demonstrated against 30 of 32 and 32 of 32 strains tested at the concentrations readily achievable in serum. In the presence of 1 mg/l of sulbactam or cefoxitin, more than 90% of the Bacteroides isolated were inhibited by 32 mg/l of cefsulodin. The inhibitory activity of cefsulodin-sulbactam or cefsulodin-cefoxitin combinations was bactericidal against Bact. fragilis and Bact. vulgatus. In contrast, no synergistic inhibitory or bactericidal activities can be observed by the cefsoludin-cefotaxime combination. Both sulbactam and cefoxitin were potent inhibitors of beta-lactamases produced by Bact. fragilis and Bact. melaninogenicus suggesting that this inhibitory activity might be one of the factors contributing to the synergistic combinations.
D001439:Bacteroides / Q000187:drug effects* / Q000201:enzymology; D002440:Cefoxitin / Q000494:pharmacology*; D002441:Cefsulodin; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D010397:Penicillanic Acid / Q000494:pharmacology*; D013045:Species Specificity; D013407:Sulbactam; D065093:beta-Lactamase Inhibitors
D002511:Cephalosporins; D065093:beta-Lactamase Inhibitors; D002440:Cefoxitin; D010397:Penicillanic Acid; D002441:Cefsulodin; D013407:Sulbactam