[Neurochemical control of cerebral blood circulation].
A neurochemical approach to a study of the mechanisms by which cerebral circulation is controlled made it possible to discover the capability of GABA, GHBA, gamma-butyrolactone and pyrrolidone-2 to enhance cerebral circulation, to relax and enlarge an isolated flap of the cerebral arteries. GABA and specific GABA-receptors were found in the tissues of the walls of the cerebral arteries. Glutamate decarboxylase and GABA-transaminase were discovered in the cerebral vessels, with the endothelial and muscle layers of the arterial walls showing the highest GABA-transaminase activity. It is evident that as regards certain biochemical characteristics there is a definite similarity between GABA-ergic neurons and tissues of cerebral artery walls, which may ensure similar and undirectional neurochemical reactions in the brain and in the walls of its arteries. The latter circumstance is responsible for the mechanisms that control the functioning of the cerebral vessels.
D015107:4-Butyrolactone / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002536:Cerebral Arteries / Q000187:drug effects / Q000201:enzymology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002799:Cholinergic Fibers / Q000378:metabolism; D018756:GABA Antagonists; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006706:Homeostasis; D006801:Humans; D011760:Pyrrolidinones / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000187:drug effects; D011963:Receptors, GABA-A; D012978:Sodium Oxybate / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis / Q000502:physiology
D018756:GABA Antagonists; D011760:Pyrrolidinones; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D005968:Glutamate Decarboxylase; D015107:4-Butyrolactone
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