title: Effect of ACTH on the composition of the aqueous humour of the rabbit eye.
abstract: Tetracosactide (Synacthen, Ciba) increases the concentration of corticosterone in the aqueous humour of the rabbit eye. The maximal increase, about 5-fold of the basal level, occurs with a slight delay of approximately 30 min after the maximally stimulated corticosterone level in blood plasma. Glucocorticoid elevation is paralleled by an increase of protein content and a slight rise of glucose in aqueous. A disruption of the blood-aqueous barrier by ACTH similar to the action of alpha-melanocyte-stimulating hormone is suggested.
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives*; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects*; D003345:Corticosterone / Q000032:analysis / Q000097:blood; D003366:Cosyntropin / Q000494:pharmacology*; D005136:Eye Proteins / Q000032:analysis; D005260:Female; D005947:Glucose / Q000032:analysis; D011817:Rabbits
chemical_list: D005136:Eye Proteins; D003366:Cosyntropin; D000324:Adrenocorticotropic Hormone; D005947:Glucose; D003345:Corticosterone