beta-Adrenoceptors in the hypertrophied right ventricle of the dog with pulmonary stenosis.
1. Right ventricular hypertrophy was produced in dogs by banding of the pulmonary artery for 28 days (n = 7) and results were compared with those in sham-operated dogs (n = 5). 2. Myocardial noradrenaline and adrenaline levels were depressed in both the hypertrophied right ventricle and the non-hypertrophied left ventricle and plasma levels were increased compared to the control dogs. 3. Myocardial beta-adrenoceptors were assessed in membrane preparations of both ventricles by 3H-dihydroalprenolol binding. No change in binding site concentration (pmol/mg membrane protein) or in binding affinity was found in either the hypertrophied right ventricle or in the left ventricle. 4. Divergent results of studies on beta-adrenoceptors in ventricular hypertrophy are difficult to reconcile.
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism; D004082:Dihydroalprenolol; D004285:Dogs; D066298:In Vitro Techniques; D008566:Membranes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011666:Pulmonary Valve Stenosis / Q000150:complications / Q000378:metabolism*; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D002395:Catecholamines; D011941:Receptors, Adrenergic; D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol