Evaluation of combination chemotherapy in Wistar/Furth rats bearing transplantable Wilms' tumor.
Wistar/Furth rats received chemotherapy with vincristine, actinomycin D and adriamycin alone and in combination following renal subcapsular implantation of a transplantable murine Wilms' tumor and nephrectomy. Each agent prolonged survival significantly compared to control, and both two-drug regimens were superior to single agent therapy. The two-drug programs were equally effective. No drug regimen was effective in preventing abdominal recurrence.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009368:Neoplasm Transplantation; D009392:Nephrectomy; D051381:Rats; D011920:Rats, Inbred WF; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery
D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin