Differential inhibitory effects of retinoic acid on Epstein-Barr virus induction in producer and nonproducer cell lines.
The effects of retinoic acid on Epstein-Barr virus (EBV) antigen induction by 12-O-tetradecanoyl-phorbol-13-acetate, 5-iodo-2'-deoxyuridine, and n-butyrate and by combinations of them were examined in two virus-producer and two nonproducer cell lines. Irrespective of the inducers used, the induction was markedly inhibited in the nonproducer lines and only weakly inhibited in the producer lines. The possible sites of action of retinoic acid are discussed.
D002087:Butyrates / Q000037:antagonists & inhibitors; D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D007065:Idoxuridine / Q000037:antagonists & inhibitors; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors; D014212:Tretinoin / Q000494:pharmacology*; D014775:Virus Activation / Q000187:drug effects*; D014776:Virus Cultivation
D002087:Butyrates; D014212:Tretinoin; D007065:Idoxuridine; D013755:Tetradecanoylphorbol Acetate