The role of cyclic AMP, calcium, and prostaglandins in the induction of osteoclastic bone resorption associated with experimental tooth movement.
Administration of imidazole and verapamil inhibited the appearance of osteoclasts and bone resorption induced by experimental tooth movement in rats. On the other hand, administration of theophylline and ouabain enhanced the appearance of osteoclasts. A mixed solution of DB cyclic AMP and A-23187 injected in gingiva near the orthodontically-treated teeth caused enhancement of the appearance of osteoclasts and bone resorption.
D000818:Animals; D001862:Bone Resorption / Q000473:pathology / Q000503:physiopathology*; D002118:Calcium / Q000494:pharmacology* / Q000502:physiology; D000242:Cyclic AMP / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D010010:Osteoclasts / Q000187:drug effects / Q000502:physiology*; D011453:Prostaglandins / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014087:Tooth Movement Techniques
D011453:Prostaglandins; D000242:Cyclic AMP; D002118:Calcium