[Vaccinating properties of the Kekava 55 strain of attenuated Marek's disease virus].
Two attenuated strains of oncogenic herpes virus, Marek's disease virus, were obtained: one by cultivation in chick fibroblast cultures at 37 degrees C, the other at 41 degrees C, i. e. at chicken body temperature. Both attenuated strains throughout a large number of passages retain high vaccination efficacy, on the average 76% and 77.3%, respectively. The virus attenuated at 41 degrees C is superior to that attenuated at 37 degrees C in higher reproduction rate in vitro and, possibly, in a greater range of passages during which good vaccinating properties are retained. Unlike turkey herpes virus, both attenuated strains reduce the spread of the infection markedly.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002645:Chickens; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D008381:Herpesvirus 2, Gallid / Q000276:immunology*; D008380:Marek Disease / Q000517:prevention & control; D013696:Temperature; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D000956:Antigens, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
Vaktsiniruiushchie svoĭstva attenuirovannogo virusa bolezni Mareka, shtamm Kekava 55.