Hypothalamic and preoptic area alpha 1-receptor concentrations decrease, and cerebral cortical alpha 1-receptor concentrations increase during postnatal maturation of male guinea pigs.
alpha 1-Receptors were measured in intact male guinea pigs during the course of postnatal development. Receptor concentrations were significantly higher at day 1 in hypothalamus and at days 1 and 14 in preoptic area than at day 60. Conversely, in cerebral cortex, receptor concentrations were significantly lower in neonatal animals than in 60-day-old animals. There was no change in affinity of the receptor during development. Castration has no apparent effect on alpha 1-receptor concentration in any brain area.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development*; D002369:Castration; D002540:Cerebral Cortex / Q000032:analysis*; D006168:Guinea Pigs; D007031:Hypothalamus / Q000032:analysis*; D008297:Male; D011224:Prazosin / Q000378:metabolism; D011301:Preoptic Area / Q000032:analysis*; D011942:Receptors, Adrenergic, alpha / Q000032:analysis*; D012741:Sexual Maturation
D011942:Receptors, Adrenergic, alpha; D011224:Prazosin