Multiple opiate receptors in the mouse vas deferens.
The agonist potencies of normorphine and [D-Ala2,D-Leu5]enkephalin (DADL) have been determined on the mouse vas deferens preparation under different conditions. Reducing the temperature at which the assay was performed had little effect on the response to DADL whilst the Emax of normorphine was greatly reduced. Tissues rendered tolerant to either agent exhibited little, if any, cross-tolerance to the other drug. The results suggest the presence of at least two types of opiate receptor in the mouse vas deferens.
D000818:Animals; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009022:Morphine Derivatives / Q000494:pharmacology; D009130:Muscle, Smooth / Q000502:physiology*; D011957:Receptors, Opioid / Q000502:physiology*; D013696:Temperature; D014649:Vas Deferens / Q000502:physiology
D009022:Morphine Derivatives; D011957:Receptors, Opioid; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C010616:normorphine