Pronounced production of polyclonal immunoglobulin G1 in the synovial fluid of goats with caprine arthritis-encephalitis virus infection.
Infection of goats with caprine arthritis-encephalitis virus, a lentivirus, resulted in arthritis characterized by the production of intrasynovial immunoglobulin G1 concentrations that were 2 to 5.3 times the serum concentrations in the inoculated carpi at 6 months postinoculation. The intrasynovial immunoglobulin was polyclonal, and its presence was accompanied by increased albumin leakage into the joints. Synovial fluid immunoglobulin levels fluctuated temporally but remained elevated compared with medium-inoculated controls for 38 months after infection. Elevated immunoglobulin G1 concentrations correlated with focal sublumenal plasmacytic infiltrates in the synovia of inoculated carpi at 5 months postinoculation. Inflammation in the uninoculated joints of infected goats was also accompanied by increased intrasynovial immunoglobulin G1 levels. Antibody to systemically administered antigens was a greater proportion of the immunoglobulin population in sera than in synovial fluids of infected goats, suggesting that antibody production to local antigens was responsible for increased intrasynovial immunoglobulin G1 levels.
D000818:Animals; D001170:Arthritis, Infectious / Q000276:immunology*; D004660:Encephalitis / Q000276:immunology*; D006041:Goats / Q000276:immunology*; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis*; D007525:Isoelectric Focusing; D013582:Synovial Fluid / Q000276:immunology*; D013997:Time Factors; D014777:Virus Diseases / Q000276:immunology*; D014790:Visna-maedi virus
D007074:Immunoglobulin G