Two mechanisms are involved in the process of iron-uptake by rat reticulocytes.
The iron uptake by red cell precursors has been studied in the presence of the carboxylic ionophore monensin, which achieves a concentration dependent inhibition of iron uptake, without influencing the transferrin uptake. It seems that two mechanisms are involved: Iron is released from endocytosed transferrin by acid vesicles. Iron is released from surface-receptor-bound transferrin at the plasma membrane, without internalization of the transferrin receptor complex.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004705:Endocytosis; D005663:Furans / Q000008:administration & dosage*; D007501:Iron / Q000097:blood*; D008985:Monensin / Q000008:administration & dosage*; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism; D011990:Receptors, Transferrin; D012156:Reticulocytes / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism
D005663:Furans; D011956:Receptors, Cell Surface; D011990:Receptors, Transferrin; D014168:Transferrin; D008985:Monensin; D007501:Iron