[Development of oncogene study].
The presence of oncogene was proved in 1969 with avian sarcoma virus B77. Since then, the first oncogene was identified as src gene and many other oncogenes have been found and characterized in various sarcoma and acute leukosis viruses. These oncogenes have cellular counterparts called "c-onc"s. They appeared to be the origins of viral oncogenes and some of them were actually proved to be oncogenic after coupling with viral LTR or insertion into retroviral genome. The importance of activation of c-onc in general carcinogenesis was discussed in relation to recent advances in human cancer gene study.
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics; D002415:Cats; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism; D009857:Oncogenes; D009876:Operon; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics; D011817:Rabbits; D051381:Rats; D012190:Retroviridae / Q000235:genetics; D014443:Tyrosine / Q000378:metabolism
D004279:DNA, Viral; D009363:Neoplasm Proteins; D012367:RNA, Viral; D014443:Tyrosine; D010770:Phosphotransferases