title: The DNA of an IPV strain of bovid herpesvirus 1 in sacral ganglia during latency after intravaginal infection.
abstract: Two calves were inoculated intravaginally with a strain of bovid herpesvirus type 1 (BHV-1, IBR/IPV) isolated from a cow with infectious pustular vulvovaginitis (IPV). The animals were killed during a latent stage of infection as characterized by seroconversion, absence of virus shedding and recrudescence of virus shedding after dexamethasone treatment. IPV-virus DNA was detected in 9 out of 20 sacral ganglia of the 2 calves. Of the sections, 7.2% (n = 250) contained 1 cell with IPV-virus DNA, which was restricted to the nucleus of neurons. In agreement with findings on herpes simplex virus infections, the viral DNA of BHV-1 is harbored in the local sensory ganglia. Virological and serological implications of the latent IPV infection are discussed.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D002467:Cell Nucleus / Q000382:microbiology; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis*; D015246:Deoxyribonuclease EcoRI; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005727:Ganglia, Spinal / Q000382:microbiology*; D006566:Herpesviridae Infections / Q000382:microbiology / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000235:genetics*; D007241:Infectious Bovine Rhinotracheitis / Q000382:microbiology; D009474:Neurons / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D012668:Trigeminal Ganglion / Q000382:microbiology; D014848:Vulvovaginitis / Q000382:microbiology / Q000662:veterinary*
chemical_list: D004279:DNA, Viral; D003907:Dexamethasone; D004262:DNA Restriction Enzymes; D015246:Deoxyribonuclease EcoRI