Centrally administered N-terminal fragments of ACTH (1-10, 4-10, 4-9) display convulsant properties in rabbits.
Electroencephalographic and behavioral effects of the following ACTH fragments: 1-4, 4-9, 4-11, 1-10, 4-10, 1-13, 1-17 and 1-24 were studied in rabbits. Sequences 4-9, 1-10 and 4-10 displayed some epileptic properties, i.e., they induced epileptic seizures (only electrographic or also behavioral) or increased hippocampal spiking. The 4-9 sequence seemed to be the common sequence responsible for these proconvulsant effects. The possible involvement of the enkephalinergic system is discussed.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D003292:Convulsants; D006624:Hippocampus / Q000187:drug effects; D007276:Injections, Intraventricular; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced
D003292:Convulsants; D010446:Peptide Fragments; C011393:ACTH (1-10); C028024:ACTH (4-9); D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)