Large-T-antigen-p53 complex formation is not cold sensitive in a cold-sensitive transformant induced by simian virus 40 mutant tsA1499.
F111 rat cells transformed by simian virus 40 mutant tsA1499 are cold sensitive for the expression of transformation. Yet, unlike F111 cells transformed by tsA58, they do not lose the ability to stabilize the transformation-associated host cell protein p53 at the temperature at which transformation is extinguished.
D000818:Animals; D000952:Antigens, Polyomavirus Transforming; D002460:Cell Line; D002472:Cell Transformation, Viral; D003080:Cold Temperature; D009154:Mutation; D010641:Phenotype; D010750:Phosphoproteins / Q000378:metabolism*; D051381:Rats; D013539:Simian virus 40 / Q000235:genetics*; D016159:Tumor Suppressor Protein p53; D014764:Viral Proteins / Q000378:metabolism*
D000952:Antigens, Polyomavirus Transforming; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53; D014764:Viral Proteins