Accumulation of pyrophosphate in Escherichia coli. Relationship to growth and nucleotide synthesis.
Pyrophosphate (PPi) content of Escherichia coli is increased manyfold when the growth of the cells is limited by inhibition of the synthesis of nucleotides. The accumulated PPi is immediately degraded when inhibition is released and growth allowed to resume. Other tested nutritional deficiencies (starvation of carbon source, sulfate or an amino acid) fail to induce PPi accumulation.
D011756:Diphosphates / Q000378:metabolism*; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D009711:Nucleotides / Q000096:biosynthesis*; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism
D011756:Diphosphates; D009711:Nucleotides; D011687:Purines; D011743:Pyrimidines