title: Epilepsy in childhood Down syndrome.
abstract: This report concerns 844 children with Down syndrome under 15 years of age. Of the 844 cases with Down syndrome, 1.4% have epilepsy at the present time. The types of seizures are as follows; infantile spasms in 4 cases (30.8%), generalized tonic-clonic convulsions in 6 (46.1%), Lennox-Gastaut syndrome in 1 (7.7%) and psychomotor seizure in 2 (15.4%). The onset of seizure was high in the first two years (73.7%). The occurrence of epilepsy in Down syndrome in childhood did not differ from that in the general population, but infantile spasms were prevalent in Down syndrome.
mesh_terms: D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000150:complications*; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications* / Q000188:drug therapy; D004833:Epilepsy, Temporal Lobe / Q000150:complications; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D003294:Seizures, Febrile / Q000150:complications; D013036:Spasms, Infantile / Q000150:complications; D014888:Wechsler Scales
chemical_list: D000927:Anticonvulsants; D000324:Adrenocorticotropic Hormone