Determination of serum 5-fluorocytosine concentrations in the presence of ketoconazole.
Because in-vitro antifungal synergism has been shown between the imidazoles and 5-fluorocytosine, we have evaluated the accuracy of a standard disc diffusion assay for serum 5-fluorocytosine levels in the presence of ketoconazole. In the usual clinical concentrations, ketoconazole does not interfere with the determination of serum 5-fluorocytosine levels by this standard test.
D002175:Candida / Q000187:drug effects; D003596:Cytosine / Q000031:analogs & derivatives*; D004347:Drug Interactions; D005437:Flucytosine / Q000097:blood* / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D003596:Cytosine; D005437:Flucytosine; D007654:Ketoconazole