Experimental study in rabbits of the antishock effect of anisodamine (654-2), and its mechanism of action.
The antishock effect of anisodamine (654-2) was observed in different kinds of experimental shock in groups of rabbits--due to late hemorrhage, superior mesenteric artery occlusion, and septic shock from peritonitis. The drug 654-2 significantly alleviated the progress of shock and increased the survival rate of the animals. The therapeutic effect of 654-2 was much better than that of other vasoactive drugs commonly used, such as norepinephrine, phenoxybenzamine, dopamine, and aramine. The antishock mechanism of 654-2 is probably partly due to its protective action on intestinal shock in preventing its effects becoming irreversible. The antishock action of 654-2 both by basic research workers and clinicians merits further study.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D008297:Male; D008638:Mesenteric Arteries; D008641:Mesenteric Vascular Occlusion / Q000150:complications; D010538:Peritonitis / Q000150:complications; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000503:physiopathology; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012991:Solanaceous Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
D012991:Solanaceous Alkaloids; D014662:Vasoconstrictor Agents; C003922:anisodamine