[Presence of high-affinity binding sites for thyroliberin in human pituitary adenomas secreting prolactin].
Specific high affinity binding sites for thyrotropin-releasing hormone (TRH) were demonstrated on cellular membranes from human prolactin-secreting adenomas in spite of the lack of in vivo prolactin response to TRH. One binding site was characterized. The mean value for the Kd from four adenomas was 64.8 +/- 12.5 nM. The maximal number of binding sites varied from one adenoma to another (from 80 to 450 fmoles/mg membrane proteins).
D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D011388:Prolactin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018025:Receptors, Thyrotropin-Releasing Hormone
D011956:Receptors, Cell Surface; D018025:Receptors, Thyrotropin-Releasing Hormone; D011388:Prolactin
Présence de sites de liaison de haute affinité pour la thyrolibérine dans les adénomes hypophysaires humains sécrétant de la prolactine.