title: [Fungal osteoarthritis of the knee with joint destruction treated with ketoconazole].
abstract: The authors report a case of acute fungal arthritis following traumatic inoculation (bramble prick) in a 9 year-old boy. The implicated fungus was an highly pathogenic atypical strain of Scedosporium (monosporium) apiospermum. Two surgical operations (synovectomy and arthrodesis) and antifungal treatment with ketoconazole led to recovery. The pathogenic role of this fungus and especially the importance of toxic phenomena are discussed. This case is compared with other in the literature. The part of ketoconazole in the recovery of this patient is emphasized.
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000209:etiology* / Q000628:therapy; D001174:Arthrodesis; D002648:Child; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D007654:Ketoconazole; D007718:Knee Injuries / Q000150:complications*; D008297:Male; D009181:Mycoses / Q000188:drug therapy; D010879:Piperazines / Q000627:therapeutic use; D011541:Pseudallescheria; D000074402:Synovectomy; D014950:Wounds, Penetrating / Q000150:complications*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D010879:Piperazines; D007654:Ketoconazole
vernacular_title: Ostéoarthrite mycosique du genou avec destruction articulaire traitée par kétoconazole.