The life span and osmotic fragility of erythrocytes in mice bearing benzo(a) pyrene - induced fibrosarcoma.
Red cell survival studies in mice with benzo(a) pyrene [B(a)p]-induced fibrosarcoma indicate marked reduction in RBC 51Cr t1/2. In contrast, the t1/2 of erythrocytes from B(a)p injected but tumor-free mice was not declined. Increasing tumor burden resulted in increment in the severity of this disorder, and preincubation of normal red cells with tumor supernatant caused significant reduction (p less than 0.05) in 51Cr t1/2. It is suggested that the observed alteration in RBC life span may be due to the effect of tumor. Apparently, both intrinsic and extrinsic cellular defects could be implicated for this abnormality. However, the shortened survival cannot be attributed to altered osmotic fragility, since the erythrocytes of the fibrosarcomatous mice were more resistant to hypotonic hemolysis in vitro.
D000818:Animals; D001564:Benzo(a)pyrene; D001580:Benzopyrenes; D002860:Chromium Radioisotopes; D004905:Erythrocyte Aging; D005354:Fibrosarcoma / Q000097:blood* / Q000139:chemically induced; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009996:Osmotic Fragility
D001580:Benzopyrenes; D002860:Chromium Radioisotopes; D001564:Benzo(a)pyrene