title: A fixed combination of pivmecillinam and pivampicillin in complicated urinary tract infections. Double-blind comparison with pivmecillinam alone in hospitalized patients.
abstract: A fixed combination of pivmecillinam-pivampicillin (PMPA) in a dosage of 200 + 250 mg b.i.d. was compared with pivmecillinam (PM) 400 mg b.i.d. in treatment of various types of complicated urinary tract infections in hospital patients. Urinary pathogens sensitive in vitro to both regimens, were eradicated from urine in 28/29 patients on PM and in 37/38 patients on PMPA. During the 10-day treatment, however, a new infection appeared in 10/29 patients on PM compared with 5/38 patients on PMPA. There was a good correlation between bacteriological effect and clinical response, and clinically 22/29 on PMPA showed a success or improvement compared with 14/25 on PM. Both treatments were well tolerated with mild gastrointestinal discomfort as the only side effect.
mesh_terms: D000328:Adult; D000368:Aged; D000561:Amdinocillin Pivoxil / Q000008:administration & dosage / Q000627:therapeutic use*; D000667:Ampicillin / Q000031:analogs & derivatives*; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010397:Penicillanic Acid / Q000627:therapeutic use*; D010917:Pivampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000892:Anti-Infective Agents, Urinary; D010917:Pivampicillin; D000561:Amdinocillin Pivoxil; D000667:Ampicillin; D010397:Penicillanic Acid