Strain differences in the hyperalgesic effect of a novel kappa receptor agonist, U-50488H in mice.
The administration of a kappa agonist, U- 50488H produced reduction in jumping latencies in the hot plate test in Swiss and CBA strains of mice but not in CXBH , CXBK and C57BL strains. The hyperalgesia following U- 50488H in Swiss and CBA strains might possibly be related to the antagonism of endogenous substrates for kappa receptors released during the thermonociceptive stimuli. A detailed time-course study in Swiss Strain revealed that a significant hyperalgesia was observable from 10 min up to 2 h. The present results indicate that CXBH , CXBK and C57BL strains might be deficient in kappa ligands and/or receptor levels relevant to thermonociception .
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D051379:Mice; D008815:Mice, Inbred Strains; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D011759:Pyrrolidines / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000502:physiology*; D017473:Receptors, Opioid, kappa; D013045:Species Specificity
D000700:Analgesics; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer