title: A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum Sopp.
abstract: The anthraquinone mycotoxins emodin and skyrin were examined for the inhibitory effects on murine leukemia L1210 culture cells, oxidative phosphorylation of rat liver mitochondria, and Na+, K+-activated ATPase activity of rat brain microsomes to find the differences between their modes of toxic action. Skyrin exhibited a stronger inhibitory effect than emodin on the growth of L1210 culture cells. Emodin showed a stronger uncoupling effect than skyrin on mitochondrial respiration. Skyrin inhibited Na+, K+-activated ATPase activity of rat brain microsomes but emodin did not inhibit.
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002478:Cells, Cultured; D003603:Cytotoxins; D004642:Emodin / Q000633:toxicity*; D008861:Microsomes / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
chemical_list: D000880:Anthraquinones; D003603:Cytotoxins; D000254:Sodium-Potassium-Exchanging ATPase; D004642:Emodin; C009274:skyrin