title: [Kinetic model of the gating system of the sodium channel in a Ranvier node membrane].
abstract: A kinetic model of the sodium channel gating system consisting of four subunits with three states--closed (X), open (Y) and inactivated (Z)--is proposed. For the channel to conduct, all the four subunits must be in the open state. The transitions between states X and Y are independent, while those between states X and Z are coupled, so that for the particle considered transition of one of two neighbouring particles into state Z increases the activation energy of the step by kT. The model fits rather well to the experimental data.
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism*; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D011895:Rana ridibunda; D011901:Ranvier's Nodes / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D012964:Sodium
vernacular_title: Kineticheskaia model' vorotnoĭ sistemy natrievogo kanala membrany perekhvata Ranv'e.