Intranigral methionine sulfoximine induces turning behaviour in the rat.
Unilateral infusion of methionine sulfoximine (MSO) into the substantia nigra of the rat induced contralateral rotations appearing progressively after a delay of about 100 min. The rotations were maximally antagonized by picrotoxin and bicuculline intraperitoneally injected at approximately 50-80 min after the intranigral infusion of MSO. Contraversive turning behaviour was absent after intranigral infusion of MSO in unilaterally 6-hydroxydopamine-lesioned rats.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D008717:Methionine Sulfoximine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D016627:Oxidopamine; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000187:drug effects; D011963:Receptors, GABA-A; D012399:Rotation
D001640:Bicuculline; D006892:Hydroxydopamines; D008717:Methionine Sulfoximine; D016627:Oxidopamine; D010852:Picrotoxin; D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A