Leukotrienes stimulate acid secretion from isolated gastric parietal cells.
Leukotrienes LTC4 and LTD4 display contractile effect on the stomach. The stimulation of acid secretion by LTC4, LTD4 and LTE4 was evidenced on a crude isolated cell preparation from rabbit gastric mucosa using the (14C)aminopyrine accumulation method. LTs were in the same order of potency. No potentiation with histamine, carbachol or IBMX was observed suggesting a specific mechanism for LTs on parietal cell.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D046508:Culture Techniques; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D007975:Leukotriene B4 / Q000494:pharmacology*; D011817:Rabbits; D013189:SRS-A / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical
D013189:SRS-A; D007975:Leukotriene B4; D006632:Histamine; D002217:Carbachol