Placental transfer of cefotiam dihydrochloride.
The concentrations of cefotiam dihydrochloride (CTM) in maternal and fetal blood and in amniotic fluid were determined by bioassay in 38 women at parturition. With an intravenous infusion of 1 g of CTM, the decline in concentration of CTM in maternal blood was biphasic; CTM  was not detectable at 6 h after administration. Peak levels of CTM in umbilical cord blood (13.0 to 23.9 micrograms/ml) were attained between 15 and 28 min after intravenous infusion; those in amniotic fluid (19.6 to 23.5 micrograms/ml) were attained at ca. 2.5 h.
D000653:Amniotic Fluid / Q000378:metabolism*; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D015310:Cefotiam; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D015310:Cefotiam; D002439:Cefotaxime