Serum testosterone, LH, and FSH in patients with testicular cancer before and after radio- and chemotherapy.
Serum levels of testosterone, luteinizing hormone and follicle-stimulating hormone were measured in 73 patients with germ cell testicular cancer in stages I and II. Blood samples were taken after unilateral orchidectomy but immediately before irradiation and chemotherapy, and again 1 to 3 years after cessation of therapy. No difference was found between pre- and post-treatment testosterone values. Patients who received radiotherapy only, had similar pre- and post-treatment luteinizing hormone values, whereas the patients who received chemotherapy in addition to irradiation still had elevated luteinizing hormone values 1 to 3 years after cessation of therapy. These values fell towards the pretreatment levels during the follow-up period. Levels of follicle-stimulating hormone were already higher than normal before treatment and increased further during treatment.
D000328:Adult; D003131:Combined Modality Therapy; D004407:Dysgerminoma / Q000097:blood / Q000628:therapy*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000628:therapy*; D013736:Testicular Neoplasms / Q000097:blood / Q000628:therapy*; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone