[Changes in the adrenocortical and sympathoadrenal activity in 8-9-year-old dogs during physical exertion and prostaglandin E2 administration].
Intraarterial administration of PGE2 to dogs over 8-9 years was followed by a short-term activation of corticotrophin. The content of glucocorticoids remained unchanged. The decrease of the noradrenaline content in dog arterial blood in response to PGE2 administration did not depend essentially on the age, whereas the exercise stimulated its release in the blood but to an insignificant degree. Dexamethasone reduced the activity of the hypothalamus-hypophysis-adrenal system, thereby making less powerful the response to PGE2 on the part of the system under study and removing the inhibitory action of PGE2 on the noradrenaline release.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000502:physiology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000375:Aging; D000818:Animals; D003864:Depression, Chemical; D003907:Dexamethasone / Q000494:pharmacology; D015232:Dinoprostone; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D005082:Physical Exertion; D011458:Prostaglandins E / Q000494:pharmacology*
D015062:11-Hydroxycorticosteroids; D007328:Insulin; D011458:Prostaglandins E; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D008995:Monoamine Oxidase; D015232:Dinoprostone; D009638:Norepinephrine; D004837:Epinephrine
Dinamika adrenokortikal'noĭ i simpatiko-adrenal'noĭ aktivnosti u sobak 8-9-letnego vozrasta pri fizicheskoĭ nagruzke na fone vvedeniia prostaglandina E2.