Allelic inclusion in the pre-B-cell line 18-81.
In an Abelson-virus-transformed mouse lymphoid cell line with pre-B-cell characteristics, a few cells continuously produce heavy chains from both homologs. Each chain has a different variable region. These cells thereby exhibit allelic inclusion rather than allelic exclusion.
D000011:Abelson murine leukemia virus / Q000235:genetics*; D000483:Alleles; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D005455:Fluorescent Antibody Technique; D006825:Hybridomas / Q000276:immunology; D007146:Immunoglobulin lambda-Chains / Q000235:genetics; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D009052:Leukemia Virus, Murine / Q000235:genetics*; D051379:Mice; D009693:Nucleic Acid Hybridization; D010954:Plasmacytoma / Q000276:immunology
D007146:Immunoglobulin lambda-Chains; D007148:Immunoglobulin mu-Chains