Elevation of plasma LH in response to systemic injection of beta-endorphin antiserum in adult male rats.
A single injection of beta-endorphin antiserum into mature male rats produced approximately a 3-fold rise in plasma LH levels by 10 to 50 min, and declined by 90 min, but remained significantly elevated above pre-injection values. Control rats injected with normal rabbit serum showed no elevation in plasma LH values. These results indicate that beta-endorphin is one of the endogenous opiates that tonically depresses basal release of LH in mature male rats.
D000818:Animals; D004723:Endorphins / Q000276:immunology*; D007106:Immune Sera / Q000008:administration & dosage; D007986:Luteinizing Hormone / Q000096:biosynthesis / Q000097:blood*; D008297:Male; D009292:Narcotic Antagonists / Q000008:administration & dosage*; D011817:Rabbits; D051381:Rats; D001615:beta-Endorphin
D004723:Endorphins; D007106:Immune Sera; D009292:Narcotic Antagonists; D001615:beta-Endorphin; D007986:Luteinizing Hormone