[Biological effects of coordination compounds of transitional metals. The beta-lactamase inhibitory effect of cis-platin, 2-aminopyridine palladium chloride, clavulanic acid and penicillanic acid sulfonate CP 45,899 in the nitrocefin test and Titertek/microtiter automatic system].
The beta-lactamase-inhibiting activity of 6m-ethyl-pyrid-2-yl-ammine palladium-dichloride (Pd 25681) and cis-dichloro-diammine-platinum(II) was studied and compared with the enzyme inhibitory action of potassium clavulanate and the penicillanic acid sulfone CP 45899. Using the nitrocefin test method and the Titertek/Microtiter equipment CP 45899 and potassium clavulanate were the strongest inhibitors of the Bacillus cereus beta-lactamase. Cis-dichloro-diammine-platinum(II) was fourfold less active than the palladium complex PD 25681 in äquimolar concentration. The following ID50 values were found: CP 45899: 0.0281 microgram; K-clavulanate: 0.1274 microgram; Pd 25681: 3.8603 microgram; cis-dichlorodiammine-platinum(II): 12.5120 microgram/100 microliter.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D009942:Organometallic Compounds; D010165:Palladium / Q000494:pharmacology*; D010397:Penicillanic Acid / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology*; D013407:Sulbactam; D065093:beta-Lactamase Inhibitors
D000970:Antineoplastic Agents; D002969:Clavulanic Acids; D009942:Organometallic Compounds; D010847:Picolines; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid; D010165:Palladium; D010397:Penicillanic Acid; C039181:6-methyl-2-aminopyridine palladium dichloride; D002945:Cisplatin; D013407:Sulbactam
Biologische Wirkungen von Koordinationsverbindungen der Ubergangsmetalle. beta-Lactamasen-inhibitorische Wirksamkeit von Cis-Platin, 2-Aminopyridin-palladium-chlorid, Clavulansäure und Penicillansäure-Sulfon CP 45 899 im Nitrocefin-Test und Titertek/Microtiter-Automatensystem.