Experimental ocular herpetic infections in rabbits. Treatment with 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine.
A new acyclic nucleoside, 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BIOLF-62), was found to be efficacious in the treatment of experimental ocular herpes simplex virus infections in rabbits. Complete healing of herpetic lesions occurred in a majority of animals after six days of topical treatment, three times per day. No toxic effects were observed in uninfected, drug-treated eyes. The BIOLF-62 treatment blocked viral replication in infected eyes sufficiently to make recovery of virus from any of the drug-treated eyes impossible, whereas virus was recovered from all placebo-treated eyes.
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use* / Q000633:toxicity; D003315:Cornea / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D005123:Eye / Q000382:microbiology; D015774:Ganciclovir; D007635:Keratitis, Dendritic / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D008297:Male; D011817:Rabbits; D018139:Simplexvirus / Q000302:isolation & purification
D000998:Antiviral Agents; D015774:Ganciclovir; D000212:Acyclovir