Inhibitory effect of fasting on the activation of liver glycogen phosphorylase of rats by arginine-vasopressin.
The i.v. bolus of 50 ng kg-1 Arginine-vasopressin administered to adult male rats anaesthetized with Pentobarbital (50 mg kg-1 i.p.) increases the activity of liver glycogen phosphorylase in fed and 24 h fasted rats to the same extent; after 25 ng kg-1 of the drug the enzyme response after fasting is barely detectable, whereas in the fed animals a response similar to that after 50 ng kg-1 persists.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000502:physiology; D004789:Enzyme Activation / Q000187:drug effects; D005215:Fasting; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D006005:Phosphorylases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D008112:Liver Glycogen; D001127:Arginine Vasopressin; D000242:Cyclic AMP; D006005:Phosphorylases