[Effect of antiestrogen and antiandrogen derivatives of acylhydrazines on properties of nucleoside triphosphatases and adenyl nucleotide content of nuclei of normal and tumor cells].
Influence of antiestrogen and antiandrogen derivatives of acylhydrazine, potentiating the antitumoral effect of cytostatics, on properties of nucleoside triphosphatases (NTPases), adenylate content in nuclea of normal and tumoral cells was studied. It was shown that acylhydrazines activated specifically the intranuclear NTPase of normal and tumoral cells. Activity of nuclear membrane-linked NTPases from liver cells was also increased after administration of acylhydrazines, sex hormones or phenobarbital. The increase in activity of intranuclear NTPase (namely ATPase) correlated with decrease of adenylates (ADP, ATP) in nuclea isolated from tumors after simultaneous treatment with acylhydrazines and thiophosphamide. Distinct increase in sensitivity of tumoral cell DNA to the effect of these alkylating preparations appear to be due to noncompensated decrease in content of ATP.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D006834:Hydrazines / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D043583:Nucleoside-Triphosphatase; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D012510:Sarcoma 180 / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000227:Adenine Nucleotides; D000726:Androgen Antagonists; D004965:Estrogen Antagonists; D006834:Hydrazines; D010744:Phosphoric Monoester Hydrolases; D000251:Adenosine Triphosphatases; D043583:Nucleoside-Triphosphatase
Deĭstvie antiéstrogenov i antiandrogenov iz klassa atsilgidrazinov na svoĭstva nukleozidtrifosfataz i na soderzhanie adenilovykh nukleotidov v iadrakh normal'nykh i opukholevykh kletok.