[Effect of ribamidil on the reproduction of the herpes simplex virus in a CV1 cell culture].
Cytotoxic properties and antiviral activity of abnormal nucleoside ribamidile were studied on the model of herpes simplex virus type 1 in CV1, continuous cell culture. The drug produced no cytotoxic effect even in concentrations of 500 and 250 micrograms/ml but had a marked capacity to inhibit herpes simplex virus reproduction in this system in concentrations of 125 and 62.5 micrograms/ml. Antiviral effect of ribamidile was enhanced by its combined use with 5'-deoxy-5'-fluorothymidine.
D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D004247:DNA / Q000096:biosynthesis; D015224:Dideoxynucleosides; D004357:Drug Synergism; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*; D013936:Thymidine / Q000031:analogs & derivatives / Q000494:pharmacology; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*
D015224:Dideoxynucleosides; D012263:Ribonucleosides; C040623:5'-deoxy-5'fluorothymidine; D012254:Ribavirin; D004247:DNA; D013936:Thymidine
Vliianie ribamidila na reproduktsiiu virusa prostogo gerpesa v kul'ture kletok CV1.