Influence of polyethylene glycol on the structure of the erythrocyte membrane: an ESR study.
Using a fatty acid spin label (I (10, 3)) it was found that the membrane fluidity of intact human erythrocytes is not influenced by polyethylene glycol (PEG) up to a concentration of 10 wt%. On the contrary a drastic effect of PEG on the spectrum of maleimide spin labeled membrane proteins of erythrocyte ghosts were detected. It is suggested that aggregation and/or conformational changes of membrane proteins were induced by PEG.
D001798:Blood Proteins / Q000032:analysis; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D004910:Erythrocyte Membrane / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D011092:Polyethylene Glycols / Q000494:pharmacology*
D001798:Blood Proteins; D011092:Polyethylene Glycols