Effect of a new GABA-ergic substance gabalid on brain bioelectric activity of cat.
The effect of the GABA-ergic substance gabalid on the bioelectric activity of cats was studied using electrodes introduced into substantia nigra (SN), nucleus caudatus (NC), Amygdala basolateralis ( Abl ), mesencephalic reticular formation (MRF) and sensor motor cortex (Sm). Gabalid was administered i.p. in doses of 100 to 200 mg/k increased amplitude and frequency of spontaneous and evoked EEG activity in NC. Suppression of mean amplitude, driving reaction and evoked potentials was observed in Abl . Most expressive were the changes in the ECoG activity. We observed many regularly appearing bursts of high-amplitude alow "spindles" and an increase in the number of medium and high-amplitude waves.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D004558:Electric Stimulation; D004569:Electroencephalography; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000378:metabolism; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*
D011956:Receptors, Cell Surface; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; C036611:gabalid