Establishment of Epstein-Barr virus (EBV) infection in epithelial cells derived from the nasopharynx by cell fusion.
To establish EBV-infection in the nasopharyngeal epithelial cells, we carried out cell fusion of the lymphocytes with nasopharyngeal epithelial cells, and proved that it was possible to detect the appearance of EBNA in the epithelial nuclei. It is suggested that the establishment of EBV-infection in nasopharyngeal epithelial cells may include cell fusion and involvement of the EBV receptors.
D000956:Antigens, Viral / Q000032:analysis; D002459:Cell Fusion; D002460:Cell Line; D002467:Cell Nucleus / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000382:microbiology; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D009305:Nasopharynx / Q000166:cytology / Q000276:immunology / Q000382:microbiology*; D011991:Receptors, Virus / Q000276:immunology
D000956:Antigens, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D011991:Receptors, Virus