Neuroimmunomodulation with enkephalins: effects on thymus and spleen weights in mice.
The subcutaneous injection of either methionine-enkephalin or leucine-enkephalin in BDF1 mice resulted in a significant increase in thymus weight and a significant decrease in spleen weight. This study further supports earlier findings that the enkephalins are neuroimmunomodulators.
D000818:Animals; D004743:Enkephalin, Leucine / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000378:metabolism*; D005260:Female; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011957:Receptors, Opioid / Q000276:immunology*; D013154:Spleen / Q000254:growth & development*; D013950:Thymus Gland / Q000254:growth & development*
D011957:Receptors, Opioid; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine