Combination therapy of sodium stibogluconate and rifampin in cutaneous leishmaniasis.
Thirty-two patients having cutaneous leishmaniasis were divided into two groups: 16 were treated with sodium stibogluconate 600 mg intramuscularly daily for 12 days and 16 were treated with 600 mg rifampin daily for 21 days. The failure rate was 56% and 50%, respectively. The 17 patients who did not respond were treated with a combination of the two drugs, which produced better results in 13 of the 17 patients.
D000967:Antimony Sodium Gluconate / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005942:Gluconates / Q000008:administration & dosage*; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy*; D012293:Rifampin / Q000008:administration & dosage* / Q000627:therapeutic use
D005942:Gluconates; D000967:Antimony Sodium Gluconate; D012293:Rifampin