Peripheral adrenoceptors after sino-aortic denervation.
The effect of bilateral sino-aortic denervation on cardiac and renal cortical alpha- and beta-adrenoceptor concentrations was studied in rats by radioligand binding experiments using [3H]-prazosin (alpha 1), [3H]-yohimbine (alpha 2) and [125I]-iodocyanopindolol (beta). Cardiac alpha 1- and beta-adrenoceptor concentrations were not altered by sino-aortic denervation. There was a significant increase in beta-adrenoceptor concentration in the renal cortex of sino-aortic denervated rats compared to sham-operated controls.
D000818:Animals; D003714:Denervation; D007672:Kidney Cortex / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012850:Sinus of Valsalva / Q000294:innervation
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta