Concentrations of ceftriaxone in serum and lung tissue.
19 patients received an intravenous 5-min bolus injection of 2 g ceftriaxone at various times before thoracic surgery. Lung tissue concentrations of 31.8 micrograms/g could be maintained for at least 5 h. Serum and lung tissue concentrations of ceftriaxone are high enough to inhibit most organisms causing nosocomial and community-acquired respiratory tract infections.
D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D002443:Ceftriaxone; D003428:Cross Infection / Q000517:prevention & control; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000032:analysis*; D008875:Middle Aged; D011292:Premedication; D012141:Respiratory Tract Infections / Q000517:prevention & control; D013903:Thoracic Surgery
D002443:Ceftriaxone; D002439:Cefotaxime