[Action of propranolol on the perfusion pressure into the peripheral vasculature of rat hindquarters].
Several investigators have confirmed that beta-adrenergic blocking agents produced a sustained pressor action in anesthetized rats. In this experiment, rat hindquarters were perfused with the rat's own blood under a constant perfusion rate. The effect of propranolol administered intraarterially to the hindquarters was studied. Propranolol (0.001--0.1 mg/ml, 5 microliter intraarterial injection) produced a sustained rise in the perfusion pressure dose-dependently. In contrast, propranolol did not produce any sustained rise in the perfusion pressure of guinea pigs and rabbits. These results support that the beta-adrenoceptive vasodilation in skeletal muscle is stronger in rats than in guinea pigs and rabbits.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006614:Hindlimb / Q000098:blood supply*; D007269:Injections, Intra-Arterial; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D009132:Muscles / Q000098:blood supply; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D013045:Species Specificity; D014664:Vasodilation
D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D009638:Norepinephrine