Immunoregulatory lymphokines of T hybridomas from AIDS patients: constitutive and inducible suppressor factors.
Supernatants derived from peripheral blood mononuclear cell cultures of certain patients with the acquired immunodeficiency syndrome (AIDS) or its prodromes have the capacity to block T cell-dependent immune reactivity in vitro. T cells derived from a patient positive for antibody to the lymphadenopathy associated virus ( LAV ), and elaborating high titers of these soluble suppressor factors, were fused to a mutagenized clone of the human T lymphoblastoid cell line KE37 . Molecules capable of profoundly depressing T cell-dependent polyclonal antibody production and DNA synthetic responses, either directly or after incubation with normal adherent cells, were isolated from stable hybrid clones.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D006801:Humans; D006825:Hybridomas / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000276:immunology; D012190:Retroviridae / Q000276:immunology; D012192:Retroviridae Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D008222:Lymphokines