title: In vitro and in vivo cytotoxic activity of native and ricin conjugated monoclonal antibodies to HBs antigen for Alexander primary liver cell carcinoma cells and tumours.
abstract: In in vitro and in vivo systems, native or ricin conjugated monoclonal anti-HBs, are capable of inhibiting or slowing the growth of Alexander primary hepatocellular carcinoma cells. Failure of the immune response to this component of the hepatitis B virus may be one permissive factor in the development of some primary liver cell carcinoma in chronic HBV carriers.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D002460:Cell Line; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D051379:Mice; D012276:Ricin / Q000627:therapeutic use*
chemical_list: D000911:Antibodies, Monoclonal; D006514:Hepatitis B Surface Antigens; D012276:Ricin