[The role of granulocytic proteinases and their inhibitors in the pathogenesis of nonspecific endobronchitis (review)].
Role of granulocyte proteinases and their inhibitors, found in bronchial secretions, in pathogenesis of bronchopulmonary diseases is discussed. The acid-stable inhibitors, synthesized in bronchi, were responsible mainly for the antileukoproteinase effect in upper respiratory tract and bronchi. Influence of alpha 1-inhibitor of proteinases and other blood plasma labile inhibitors on destructive impairments in bronchopulmonary tissue is considered. Use of proteinase inhibitors as therapeutic drugs in bronchopulmonary pathologies is discussed.
D000818:Animals; D001798:Blood Proteins; D001980:Bronchi / Q000378:metabolism*; D001991:Bronchitis / Q000201:enzymology*; D002403:Cathepsins / Q000032:analysis; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000097:blood; D010450:Endopeptidases / Q000032:analysis*; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000201:enzymology; D003012:Microbial Collagenase / Q000032:analysis; D010196:Pancreatic Elastase / Q000032:analysis; D011480:Protease Inhibitors / Q000097:blood*; D011656:Pulmonary Emphysema / Q000201:enzymology; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin / Q000097:blood
D001798:Blood Proteins; D011480:Protease Inhibitors; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D002403:Cathepsins; D010450:Endopeptidases; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D003012:Microbial Collagenase
Rol' proteinaz granulotsitov i ikh ingibitorov v patogeneze nespetsificheskikh éndobronkhitov (obzor).