title: [Effect of antioxidants of the 3-hydroxypyridine class on cyclic 3', 5'-adenosine monophosphate phosphodiesterase activity].
abstract: It was shown that derivatives of oxypyridine inhibit activity of 3,5-AMP phosphodiesterase I and II from the rabbit heart. 2-ethyl-6-methyl-3-oxypyridine and proxypheine inhibited 3,5-AMP phosphodiesterase activity in human lymphocytes substantially higher than theophilline widely used in clinical practice.
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D011431:Dextropropoxyphene / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010847:Picolines / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D000975:Antioxidants; D010847:Picolines; C039425:2-tert-butyl-6-methyl-3-hydroxypyridine; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D011431:Dextropropoxyphene; C009820:6-methyl-2-ethyl-3-hydroxypyridine
vernacular_title: Vliianie antioksidantov iz klassa 3-oksipiridina na aktivnost' fosfodiésterazy tsiklicheskogo 3', 5'-adenozinmonofosfata.