Synthesis and biological activity of vitamin D3 analogues.
Many analogues of vitamin D metabolites including stereochemical isomers and fluorine substituents were synthesized, and their biological activities were determined by in vitro and in vivo assays. Among those analogues, 24,24-F2-1,25-(OH)2D3 and 26,26,26,27,27,27-F6-1,25-(OH)2D3 are more active than the most potent naturally occurring vitamin D3 metabolite, 1,25-(OH)2D3.
D000818:Animals; D002117:Calcitriol / Q000378:metabolism; D002642:Chick Embryo; D002762:Cholecalciferol / Q000138:chemical synthesis / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D009924:Organ Culture Techniques; D051381:Rats; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000096:biosynthesis; D013329:Structure-Activity Relationship; D014808:Vitamin D Deficiency / Q000378:metabolism
D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D064030:S100 Calcium Binding Protein G; D002762:Cholecalciferol; D002117:Calcitriol