Prolonged survival of experimental heart transplantation induced by theophylline.
High levels of cyclic adenosine monophosphate (cAMP) in lymphocytes are associated with a reduction in many immunological functions. Theophylline, a drug effective in elevating lymphocyte cAMP levels, was employed as a single immunomodulator treatment in rats submitted to heterotopic heart allotransplantation. In 3 strain combinations, the graft survival was consistently prolonged in treated animals in comparison with untreated controls.
D000008:Abdominal Neoplasms; D000628:Aminophylline / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D002828:Choristoma; D000242:Cyclic AMP / Q000096:biosynthesis; D006085:Graft Survival / Q000187:drug effects*; D016027:Heart Transplantation; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains
D000628:Aminophylline; D000242:Cyclic AMP