title: Estimation of the single stranded region in the nuclear DNA of mouse tissues during aging with special reference to the brain.
abstract: The proportion of single stranded DNA in various tissues of mouse during aging was examined by measuring sensitivity to a single-strand specific nuclease. Brain DNA from mice of more than 15 mth old contained 3% of the single stranded regions while that from younger animals contained 2%. The DNAs from liver, kidney, heart and spleen did not show significant age-associated changes.
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000378:metabolism*; D004720:Endonucleases; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D015719:Single-Strand Specific DNA and RNA Endonucleases; D013154:Spleen / Q000378:metabolism
chemical_list: D004277:DNA, Single-Stranded; D004720:Endonucleases; D015719:Single-Strand Specific DNA and RNA Endonucleases