Bovine lymphosarcoma: processing of bovine leukaemia virus-coded proteins.
This report describes pulse-chase experiments performed with cells infected with tumour-derived bovine leukaemia virus (BLV) and using purified gamma-globulins directed against BLV structural proteins, namely gp51, p24, p15 and p12. A gpr72 was found to be the precursor of the gp51 with a gpr70 intermediate. The p12 was shown to be derived from a pr40 with numerous intermediates (pr35, pr22, pr16 and pr14). The p24 and p15 originate from a pr42. Both the pr42 and pr40 are derived from a common pr70. A P45, a P52 and a P27 were also detected. Because these three proteins were found to accumulate progressively in cells and because they were not observed to be processed, they might play a physiological role in infected cells.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D007700:Kinetics; D001909:Leukemia Virus, Bovine / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D012190:Retroviridae / Q000378:metabolism*; D014759:Viral Envelope Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism*; D015678:Viral Structural Proteins
D011498:Protein Precursors; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D015678:Viral Structural Proteins