title: [Resorption of hydrocyanic acid from linseed].
abstract: Resorption of hydrocyanic acid after ingestion of linseed was investigated in 20 healthy volunteers and 5 patients. The persons investigated took a single dose of 30 g or of 100 g of linseed or they received throughout several weeks 15 g. t.i.d. One volunteer also took for purposes of comparison bitter almonds or potassium cyanide. Before, during and after the periods of ingestion plasma levels of hydrocyanic acid and of thiocyanate were normal. During long-term trials urinary excretion of thiocyanate was monitored regularly. Intake of linseed even in extremely high dosages never caused significant rises of plasma thiocyanate levels; this, however, was the case after intake of bitter almonds or potassium cyanide. Thus, it can be excluded, that intoxication by hydrocyanic acid can be caused by linseed. Long-term intake of linseed however, raised plasma levels of thiocyanate significantly; at the same time urinary excretion of thiocyanate increased.
mesh_terms: D000328:Adult; D003248:Constipation / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D006856:Hydrogen Cyanide / Q000097:blood*; D007408:Intestinal Absorption; D008043:Linseed Oil / Q000009:adverse effects*; D008297:Male; D008657:Metabolic Clearance Rate; D011190:Potassium Cyanide / Q000097:blood; D013861:Thiocyanates / Q000097:blood
chemical_list: D013861:Thiocyanates; D006856:Hydrogen Cyanide; D008043:Linseed Oil; D011190:Potassium Cyanide
vernacular_title: Resorption von Blausäure aus Leinsamen.