Effect of chronic hypoxia on angiotensin-induced pulmonary vasoconstriction and converting enzyme activity in the rat.
Rats were exposed to high-altitude (5500 m) hypoxia for 2 weeks. On examination 1-3 days after return to sea level and compared with control rats, they exhibited pulmonary hypertension, reduced angiotensin-converting enzyme activity, greater vascular responsiveness to angiotensin II (AII), and resistance to blockade of AII pulmonary pressor responses by the AII antagonist, saralasin.
D000532:Altitude Sickness / Q000503:physiopathology*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011651:Pulmonary Artery / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*
D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D012504:Saralasin