title: Minireview. Roles of turnover and repair of macromolecules and supramolecular structural components.
abstract: Macromolecules and supramolecular structural components that are incorrectly synthesized or are damaged by radiation or by reactive chemicals are either repaired or selectively degraded and resynthesized. In addition, turnover rates for macromolecules and supramolecular structures can be elevated by alternation of fasting and feeding periods and can be influenced by metabolic regulatory mechanisms which are governed by steady-state concentrations of labile macromolecules.
mesh_terms: D000818:Animals; D001260:Ataxia Telangiectasia / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D005215:Fasting; D005502:Food; D005609:Free Radicals; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood; D008054:Lipid Peroxides / Q000378:metabolism; D046911:Macromolecular Substances; D008706:Methemoglobin / Q000378:metabolism; D010084:Oxidation-Reduction; D010447:Peptide Hydrolases / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011108:Polymers / Q000528:radiation effects; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013481:Superoxides / Q000494:pharmacology; D014158:Transcription, Genetic; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000378:metabolism
chemical_list: D005609:Free Radicals; D006454:Hemoglobins; D008054:Lipid Peroxides; D046911:Macromolecular Substances; D010743:Phospholipids; D011108:Polymers; D011506:Proteins; D013438:Sulfhydryl Compounds; D013481:Superoxides; D004247:DNA; D008706:Methemoglobin; D007501:Iron; D010447:Peptide Hydrolases