Oesophageal function after oral ranitidine: an acute double blind study in normal subjects.
The effect of oral ranitidine on oesophageal peristalsis, LOS basal pressure and gastro-oesophageal acid reflux, was investigated in 6 healthy men in a double-blind randomized study. Simultaneous manometry and pH measurements were performed twice in each volunteer during a five hour study period which included the administration of a standard meal. Ranitidine did not affect the motor parameters studied (amplitude, duration and velocity of the peristaltic waves and LOS basal tone), whereas it almost abolished acid gastroesophageal reflux. Our results show that ranitidine, like cimetidine, does not alter the motor function of the oesophagus, while it virtually abolishes acid gastro-oesophageal reflux in normal man.
D000284:Administration, Oral; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004947:Esophagus / Q000187:drug effects* / Q000502:physiology; D005750:Gastric Juice / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010528:Peristalsis / Q000187:drug effects; D011897:Random Allocation; D011899:Ranitidine / Q000008:administration & dosage / Q000494:pharmacology*; D011970:Receptors, Histamine H2 / Q000187:drug effects
D011970:Receptors, Histamine H2; D011899:Ranitidine