Effects of delta 1- and delta 6-tetrahydrocannabinol on the adenylate cyclase activity in ventricular tissue of the rat heart.
Adrenaline 1 micrograms markedly elevated the activity of adenylate cyclase in ventricular tissue of rat hearts. delta 1-THC 25, 50 and 100 micrograms significantly reduced the adenylate cyclase activity with the maximum effect observed with the dose of 25 micrograms. Doses below or above this range did not produce any significant effect on the enzyme activity. Neither delta 6-THC 25 and 100 micrograms nor PVP 400 micrograms had any significant action on adenylate cyclase. The delta 1-THC-induced lowering of the cyclic AMP concentration in ventricular tissue of rat hearts can be explained, at least partly, by its ability to reduce the activity of adenylate cyclase in these tissues. It is suggested that this enzyme inhibition underlies the cardiac depressant action of delta 1-THC.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D013759:Dronabinol / Q000494:pharmacology* / Q000031:analogs & derivatives; D004837:Epinephrine / Q000494:pharmacology; D066298:In Vitro Techniques; D007536:Isomerism; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D011205:Povidone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000201:enzymology
C035731:delta-8-tetrahydrocannabinol; D013759:Dronabinol; D000262:Adenylyl Cyclases; D011205:Povidone; D004837:Epinephrine