K cell mediated haemolysis: influence of large numbers of unsensitized cells on the antibody-dependent lysis of anti-D-sensitized erythrocytes by human lymphocytes.
The inhibition of K cell mediated haemolysis of anti-D-sensitized human red blood cells by unsensitized erythrocytes has been demonstrated. Inhibition of lysis was non-competitive in nature and influenced by the size and number of unsensitized cells. However, even in the presence of high inhibitor: target cell ratios (50:1) haemolysis, although reduced, was still effected suggesting that K cells are highly motile and capable of recognizing and destroying minority populations of antibody-sensitized erythrocytes. These data are compatible with a role for cytotoxic lymphocytes in the intravascular lysis of autoantibody or alloantibody-sensitized red cells.
D000920:Antibody-Dependent Cell Cytotoxicity; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000276:immunology*; D006461:Hemolysis; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D066298:In Vitro Techniques; D007518:Isoantibodies / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D018029:Rho(D) Immune Globulin
D007136:Immunoglobulins; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin