Postpartum renal failure and malignant hypertension treated with captopril.
A case of postpartum renal failure and malignant hypertension in a 24-year-old woman is reported. The condition occurred three weeks after caesarian section following a normotensive pregnancy. Treatment with a converting enzyme inhibitor, captopril, for one year normalized the blood pressure, with concurrent reduction of plasma angiotension II concentration and markedly improved glomerular filtration rate. It is suggested that activation of the renin-angiotensin system may cause the hypertension and impairment of renal function in postpartum renal failure, and that use of drugs blocking the renin system may be of particular clinical value in this situation.
D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000804:Angiotensin II / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy*; D007231:Infant, Newborn; D007678:Kidney Glomerulus / Q000473:pathology; D011247:Pregnancy; D011392:Proline / Q000031:analogs & derivatives*; D011644:Puerperal Disorders / Q000188:drug therapy* / Q000473:pathology
D000804:Angiotensin II; D011392:Proline; D002216:Captopril