The effects of a fractionated gamma irradiation on life shortening and disease incidence in BALB/c mice.
BALB/c male mice (12 weeks old) were exposed to a single or fractionated exposure of 137Cs gamma rays. The fractionated dose was split into 10 equal doses delivered at an interval of 1 day. The causes and possible causes of spontaneous death were ascertained by autopsy and histological examination, and the data were treated by competing risk analysis. Life shortening followed a linear dose dependency and was about the same for fractionated (38.1 +/- 3.1 days/Gy) as for single (46.2 +/- 4.3 days/Gy) exposure. Death from tumor disease was enhanced and that from nonstochastic lung and kidney diseases was reduced after fractionated compared to single exposure.
D000818:Animals; D001344:Autopsy; D005720:Gamma Rays; D007674:Kidney Diseases / Q000209:etiology*; D008017:Life Expectancy; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011336:Probability; D011829:Radiation Dosage; D014916:Whole-Body Irradiation / Q000009:adverse effects* / Q000379:methods