Glucose intolerance in spinal cord injury.
Glucose intolerance occurs frequently in patients with spinal cord injuries (SCI). In a retrospective chart analysis 23% of 57 consecutive discharges from a large SCI service had fasting hyperglycemia, and in a screening study, 30% of a group of stable SCI patients had 2-hour glucose values exceeding 200mg/dl after a glucose load and another 40% had values exceeding 140mg/dl. The glucose intolerance in many SCI patients is characterized by hyperinsulinemia after glucose is administered orally or intravenously. More than 40% of a group of glucose intolerant SCI patients had elevated insulin levels, suggesting tissue resistance to endogenous insulin.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005934:Glucagon / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D013119:Spinal Cord Injuries / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon