Pancreatic A cell response to arginine in the hibernating hedgehog (Erinaceus europaeus).
Pancreatic A cell response to arginine was measured in hedgehogs during the periods of lethargy and arousal and then during activity. Spontaneous plasma glucagon concentrations were lower during lethargy than during activity, and they increased during arousal. Arginine administration induced a slight, but significant delayed increase in plasma glucagon concentration in the lethargic hedgehog (body temperature: 6 degrees). During arousal, in vitro glucagon secretion was temperature dependent suggesting that body rewarming might, in itself, be an important stimulating factor of the A cells. In the presence of arginine, the glucagon output of the pancreas of lethargic hedgehogs was high at low temperatures. It decreased to a nadir at 19 degrees and increased up to 37 degrees. However, the basal or arginine-stimulated glucagon secretion of animals in lethargy was higher than that of animals in activity. These characteristics suggested the presence of a particular pool of cold-adapted enzymes in the A cells of lethargic hedgehogs.
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D005934:Glucagon / Q000097:blood / Q000378:metabolism; D006364:Hedgehogs / Q000502:physiology*; D006605:Hibernation; D006706:Homeostasis; D007515:Islets of Langerhans / Q000502:physiology; D009043:Motor Activity; D012636:Secretory Rate / Q000187:drug effects
D005934:Glucagon; D001120:Arginine