Alkaline phosphatase positive lymphoma.
Alkaline phosphatase (AP) activity on cryostat sections of the skin of 38 cases of non-Hodgkin's lymphomas of the B cell type and of 10 cases of lymphadenosis benigna cutis have been studied. Membrane-bound AP activity has been found in 8 out of 28 cases of low-grade malignant lymphomas of the B cell type and in 2 out of 10 cases of lymphadenosis benigna cutis. This is a known phenomenon in the latter. In the literature of non-Hodgkin's lymphoma AP activity is related to the intermediate type of lymphocytic lymphoma. Further studies are needed to demonstrate that the AP activity correlates with a specific cell type in the B lymphoid cell differentiation.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D001402:B-Lymphocytes / Q000201:enzymology; D002462:Cell Membrane / Q000201:enzymology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000201:enzymology; D008199:Lymphadenitis / Q000201:enzymology; D008223:Lymphoma / Q000201:enzymology*; D012867:Skin / Q000201:enzymology; D012878:Skin Neoplasms / Q000201:enzymology*
D000469:Alkaline Phosphatase