title: Double blind comparative study of piroxicam and indomethacin in acute locomotor affections linked with sports activity.
abstract: 181 patients suffering from acute locomotor affections linked with sports activities were included in a multi-center study. The indications most frequently seen were sprains and tendinitis. 92 patients received piroxicam in a daily dosage of 4 capsules (40 mg) during the first two days, then 20 mg during the following days. 89 patients received a daily dose of indomethacin in a daily dose of 6 capsules (150 mg) for the first two days, and then 100 mg daily thereafter. Treatment lasted from 5 to seven days. Efficacy was judged to be very good or good in 89% of the patients treated with piroxicam against 76% of those treated with indomethacin, a statistically significant difference. Tolerance was also judged better with piroxicam. 4 patients suffered side effects with piroxicam, of which one stopped treatment after the second administration due to allergic reaction. 18 patients treated with indomethacin suffered from side effects, of which 5 stopped the treatment. In total, the use of piroxicam seems particularly interesting in sports medicine in comparison with indomethacin.
mesh_terms: D000328:Adult; D000375:Aging; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001265:Athletic Injuries / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008124:Locomotion; D008297:Male; D010146:Pain / Q000188:drug therapy; D010894:Piroxicam; D012737:Sex Factors; D013180:Sprains and Strains / Q000188:drug therapy; D052256:Tendinopathy / Q000188:drug therapy; D013843:Thiazines / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam; D007213:Indomethacin