Plasma drug levels and clinical response to antidepressants.
Antidepressants are a key treatment in depression. The wide interindividual differences in plasma levels of these agents were initially seen as an explanation for nonresponse and a potential major advance in treating depressive disorders. However, efforts to relate plasma levels to therapeutic outcome have, in general, been disappointing. In the few instances where such relationships have been claimed, they have been weak and useful only for specific and problematic clinical conditions.
D000928:Antidepressive Agents / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008996:Monoamine Oxidase Inhibitors / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D008996:Monoamine Oxidase Inhibitors