The effect of topical insulin on infected cutaneous ulcerations in diabetic and nondiabetic mice.
A study to determine the efficacy of topical insulin on wound healing in 41 diabetic and nondiabetic mice was performed. The results showed that treatment regimens that included topical insulin provided better rates of wound healing than treatment regimens in which only base preparations or controls were used. Healing rates were improved in both diabetic and nondiabetic mice.
D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004336:Drug Antagonism; D004338:Drug Combinations; D005260:Female; D007328:Insulin / Q000008:administration & dosage*; D007329:Insulin Antagonists; D008055:Lipids; D051379:Mice; D008813:Mice, Inbred ICR; D009823:Ointment Bases / Q000008:administration & dosage / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000008:administration & dosage; D012883:Skin Ulcer / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D007328:Insulin; D007329:Insulin Antagonists; D008055:Lipids; D009823:Ointment Bases; D011092:Polyethylene Glycols; C039909:eucerin