[Flavellagic acid influence on blood coagulation and hemostasis disturbed by whole body irradiation].
By experimentations in vitro with human blood, we found out that an addition of flavellagic acid influences the initial stage of the coagulation system by activating the XIIth coagulation factor. So there is another substance besides the ellagic acid that activates in solution the XIIth coagulation factor. Our experimentations on sound rats showed that an intravenous administration of flavellagic acid in a dose of 0.7 mg/kg body weight has a short-term hemostatic action and that the r and k values and the m epsilon value in the thrombelastogram are increased. There was a similar effect in rats receiving an intravenous injection of flavellagic acid on the twelfth day after a whole-body irradiation with 8.0 Gy.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects / Q000528:radiation effects*; D004610:Ellagic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D005174:Factor XII; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D051381:Rats; D013916:Thrombelastography; D014916:Whole-Body Irradiation
D001578:Benzopyrans; D004610:Ellagic Acid; C022139:flavellagic acid; D005174:Factor XII
Experimentelle Beeinflussung der durch Ganzkörperbestrahlung gestörten Blutgerinnung und Hämostase mit Flavellagsäure.