Failure of 5-hydroxytryptophan to modulate brain stem auditory evoked responses in myelin deficient mutant qk mice.
The effect of 5-hydroxytryptophan (5-HTP) on brain stem auditory evoked response (BAER) amplitude in Quaking (qk) and normal littermate mice was examined. Administration of 5-hydroxytryptophan (5-HTP) (75 mg/kg, i.p.) to normal mice increased the amplitude of BAER peaks I, II, and III but had no effect on peak IV. In qk mice, however, 5-HTP did not affect the amplitude of any BAER peaks. Our data indicate that although 5-HTP increased BAER amplitude in normal mice, it failed to modulate BAER in qk mice. These findings are consistent with the possibility that 5-HTP receptor sites associated with myelin basic protein may be reduced in the myelin-deficient mutant qk mice.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D051379:Mice; D008821:Mice, Quaking / Q000235:genetics / Q000502:physiology*; D009186:Myelin Sheath / Q000502:physiology*
D006916:5-Hydroxytryptophan