Alteration of renal baroreceptor by salt intake in control of plasma renin activity in conscious dogs.
We investigated the relationship between renal arterial pressure (RAP) and systemic plasma renin activity (PRA) in five uninephrectomized conscious dogs on normal salt (80 meq Na+/day) and low salt (10 meq Na+/day) diets. The RAP was controlled by an inflatable cuff placed around the origin of the renal artery. In both salt states the PRA was an exponential function of the RAP: log (PRA) = (-0.026 X RAP) + 2 on the normal salt diet (r = 0.96) and log (PRA) = (-0.026 X RAP) + 2.5 on the low salt diet (r = 0.99). At any RAP, the value of the low salt PRA was 3 times that of the normal salt PRA. Accordingly, a reduction in salt intake increases the sensitivity of the renal baroreceptor so that the absolute value of PRA increases at any RAP, but the percentage change in PRA caused by any change in RAP is the same in both normal and low salt states.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003243:Consciousness / Q000502:physiology; D004285:Dogs; D007668:Kidney / Q000502:physiology*; D008297:Male; D011311:Pressoreceptors / Q000502:physiology*; D012079:Renal Circulation; D012083:Renin / Q000097:blood*; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D012083:Renin