title: An evaluation of the tendency of Avitene to produce periureteral fibrosis in the dog.
abstract: This study was designed to evaluate whether a microfibrillary collagen hemostatic agent (Avitene) would cause retroperitoneal fibrosis and ureteric obstruction when applied along the side of the ureter and left in situ for a period of 6 months. The contralateral side served as a control. Serial intravenous urograms were obtained and histopathologic studies were conducted to evaluate these effects. No evidence of significant retroperitoneal fibrosis or ureteric obstruction was found either on serial intravenous urograms or on histopathologic examination of the ureter after 6 months.
mesh_terms: D000818:Animals; D003094:Collagen / Q000009:adverse effects*; D003584:Cytological Techniques; D004285:Dogs; D004341:Drug Evaluation; D005260:Female; D006490:Hemostatics / Q000009:adverse effects*; D008854:Microscopy, Electron; D011859:Radiography; D012185:Retroperitoneal Fibrosis / Q000139:chemically induced; D013997:Time Factors; D014513:Ureter / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000648:ultrastructure; D014517:Ureteral Obstruction / Q000139:chemically induced
chemical_list: D006490:Hemostatics; D003094:Collagen