title: A thiol inhibitor produced by Aspergillus niger.
abstract: A low molecular weight inhibitor of the thiol proteases papain and bromelain has been identified and partially purified from the culture filtrates of Aspergillus niger. Further studies have shown that this inhibitor reacts with compounds containing a free thiol group and as such it is capable of inhibiting other enzymes that contain a functional thiol group at their active site.
mesh_terms: D001234:Aspergillus niger / Q000032:analysis*; D001963:Bromelains / Q000037:antagonists & inhibitors; D003545:Cysteine / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors; D008623:Mercaptoethanol / Q000494:pharmacology; D010206:Papain / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D011480:Protease Inhibitors; D008623:Mercaptoethanol; D001963:Bromelains; D007770:L-Lactate Dehydrogenase; D010206:Papain; D003545:Cysteine