[Treatment of ventriculitis caused by Staphylococcus epidermidis on equipment with the combination of fosfomycin and an aminoglycoside. Course of ventricular levels of fosfomycin].
Five patients (4 adults and 1 child) with cerebrospinal fluid shunt infections caused by Staphylococcus epidermidis were successfully treated by fosfomycin combined with an aminoglycoside. Fosfomycin was given intravenously over 4 hours 3 times a day. The antibiotic dose was 12 g/day for adults and 200 mg/kg/day for the child. In 3 patients with an external CSF drainage system, serum and ventricular fluid samples were obtained before and after one infusion during 10 days. The serum concentrations varied greatly (48,12 +/- 31,47 and 115,07 +/- 46,5 micrograms/ml. However the drug levels in ventricular fluid were constant and similar for the 3 patients (24,48 +/- 10,28 à 27,87 +/- 8,58 micrograms/ml), well above the MICS (1 and 2 micrograms/ml).
D000293:Adolescent; D000328:Adult; D000368:Aged; D000617:Aminoglycosides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002552:Cerebral Ventricles / Q000378:metabolism; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects*; D002648:Child; D004359:Drug Therapy, Combination; D005578:Fosfomycin / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005578:Fosfomycin
Traitement des ventriculites à Staphylococcus epidermidis sur matériel par l'association fosfomycine-aminoside. Evolution des taux ventriculaires de fosfomycine.