Jaundice following bone marrow transplantation. The problem of diagnosis.
Jaundice presented a major diagnostic and therapeutic problem in 6 out of 20 patients undergoing allogeneic bone marrow transplantation for severe acute aplastic anaemia or leukaemia in relapse. In the first 2 cases histological features of graft-versus-host disease were demonstrable in the skin but absent in the liver. In the 3rd case B-virus hepatitis was the most likely diagnosis, in the 4th cumulative cytotoxic chemotherapy was incriminated, and in the last 2 cases the jaundice was obstructive. These 6 cases illustrate the varied causation of jaundice in patients undergoing bone marrow transplantation, and emphasize that correct diagnosis is essential for rational management.
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis; D002648:Child; D002779:Cholestasis / Q000175:diagnosis; D005260:Female; D006087:Graft vs Host Reaction; D006525:Hepatitis, Viral, Human / Q000175:diagnosis; D006801:Humans; D007565:Jaundice / Q000175:diagnosis*; D008297:Male