Auxiliary canine hepatic transplantation without portal blood flow.
Auxiliary liver transplantation for acute reversible hepatic failure has been suggested as a way to provide temporary hepatic support. The major technical difficulty in such an operation is providing portal blood flow, although it is unclear if this is necessary for short-term function of such a graft. Three groups of five dogs each underwent common duct ligation and cholecystectomy. One week later all animals underwent an end-to-side portocaval shunt. In Group I dogs only a "sham" transplant was done while those in Group II also received an auxiliary hepatic graft without portal blood flow which had been perfused with iced Collins solution and immediately grafted. Group III received similar auxiliary hepatic grafts with 22 hours of cold ischemia time. Reductions in mean total serum bilirubin values to near normal, usually lasting for one week (Group I, 12.02 mg% +/- 1.23 SEM vs. Group II, 3.58 mg% +/- 0.52 SEM, p = 0.01) were observed. Although several livers stored for 22 hours demonstrated function, there was considerable evidence of ischemic injury.
D000208:Acute Disease; D000818:Animals; D001663:Bilirubin / Q000097:blood; D004195:Disease Models, Animal; D004285:Dogs; D008102:Liver Circulation; D008107:Liver Diseases / Q000097:blood / Q000601:surgery*; D016031:Liver Transplantation
D001663:Bilirubin