Mutagenicity testing of quinine with submammalian and mammalian systems.
Quinine hydrochloride was assayed for genotoxic activity by using 4 different test systems with distinct genetic endpoints. No indications for point mutations were observed in the Ames system. In 3 cytogenetic tests performed on small rodents, Chinese hamsters showed no genotoxic activity, while inbred strains of mice revealed a dose dependent increase of SCEs, enhanced incidence of micronuclei and elevated chromatid breaks.
D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D009153:Mutagens; D011803:Quinine / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013045:Species Specificity
D009153:Mutagens; D011803:Quinine