Ultrafiltration by hyperosmotic peritoneal dialysis fluid excludes intracellular solutes.
During peritoneal dialysis, progressive increments in the osmotic gradient increase ultrafiltration rate. Solute transport by convective flux is thereby raised but there is no preferential increase in potassium clearance. The data imply that ultrafiltrate derives from extracellular fluid alone. Mesothelial cells appear to resist solute and water flux in response to an immediately adjacent osmotic gradient.
D000818:Animals; D001692:Biological Transport; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D007473:Ion Channels / Q000378:metabolism; D009997:Osmotic Pressure; D010530:Peritoneal Dialysis; D011188:Potassium / Q000378:metabolism*; D011817:Rabbits; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism
D007473:Ion Channels; D014508:Urea; D011188:Potassium