Predominant cutaneous infiltration by OKT6- and OKT8-positive cells in a case of Sézary syndrome.
Using an immunoperoxidase (skin biopsy) and an immunofluorescence (peripheral blood, bone marrow punctate) technique, and monoclonal antibodies raised against peripheral mature lymphocytes, T helper subsets, T suppressor subsets, and Langerhans cells, we found a predominant dermal infiltration with lymphocytes of the suppressor phenotype and a predominant epidermal infiltration with Langerhans cells in a patient with Sézary syndrome (cutaneous T-cell lymphoma, CTCL). Repeated peripheral blood examinations showed an increased percentage of lymphocytes of the helper phenotype. A bone marrow examination revealed a ratio of suppressor/helper subsets of 1:4. The findings in the skin seem to be inconsistent with most of the results of previous studies in patients with CTCL; the significance of these findings is discussed.
D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000473:pathology; D012751:Sezary Syndrome / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000276:immunology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal