Flurazepam and the sleep of herniorrhaphy patients.
The effects of flurazepam on the nocturnal sleep patterns of 20 pre- and postoperative herniorrhaphy patients were studied polygraphically, in double-blind fashion, in the clinical setting. Compared to patients who received no hypnotic, patients treated with flurazepam had, preoperatively, significantly more Stage 2 and less REM and, postoperatively, significantly greater total sleep time, fewer awakenings, and less total awake time. The flurazepam group also initially had more delta sleep, but then showed a steady decrease of delta sleep over the hospitalization.
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005479:Flurazepam / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D059685:Herniorrhaphy; D006801:Humans; D008297:Male; D008614:Meperidine / Q000494:pharmacology; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D010919:Placebos; D011184:Postoperative Period; D012119:Respiration / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects; D013997:Time Factors
D010919:Placebos; D008614:Meperidine; D005479:Flurazepam