title: Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation.
abstract: Insulin directly inhibits protein phosphorylation in isolated rat liver nuclear envelopes. In the present studies, an antiserum to insulin receptor as well as the plant lectins concanavalin A and phytohemagglutinin mimicked insulin action in isolated nuclear envelopes. These studies suggest that insulin and agents that mimic it may directly regulate nuclear functions.
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007106:Immune Sera; D007328:Insulin / Q000494:pharmacology*; D037102:Lectins / Q000494:pharmacology*; D009685:Nuclear Envelope / Q000187:drug effects* / Q000378:metabolism; D010766:Phosphorylation; D010835:Phytohemagglutinins / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000276:immunology*
chemical_list: D007106:Immune Sera; D007328:Insulin; D037102:Lectins; D010835:Phytohemagglutinins; D003208:Concanavalin A; D011972:Receptor, Insulin