[Activity of the creatine kinase isoenzyme CK-BB in the serum of neonates as an indicator of perinatal damage to the central nervous system].
By means of the immunoprecipitation method significantly higher activities of creatine kinase BB isoenzyme were measured in the sera of neonates with CNS symptoms than in the sera of healthy or sick neonates without CNS symptoms. The activity of CK-BB inversely correlated with the one-minute Apgar score. These results suggest a leakage of CK-BB from the damaged CNS tissue into the blood circulation. Determination of CK-BB might be helpful in the assessment of perinatal brain damage.
D001034:Apgar Score; D001925:Brain Damage, Chronic / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007158:Immunologic Techniques; D007231:Infant, Newborn; D007527:Isoenzymes
D007527:Isoenzymes; D003402:Creatine Kinase
Die Aktivität des Creatinkinase (EC 2.7.3.2)-Isoenzyms CK-BB im Serum Neugeborener als Indikator einer frühkindlichen Schädigung des zentralen Nervensystems.