Kappa-receptor antagonist reverse 'non-opioid' stress-induced analgesia.
We have evaluated the effects of antagonists to the mu, kappa and opiate receptors on 'opioid' and 'non-opioid mediated' analgesia. Our findings indicate that mu receptors might mediate 'opioid' and kappa receptors 'non-opioid' analgesia. It is suggested that endogenous opiates that act on mu or kappa receptors could be responsible for the different types of stress-induced analgesia.
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001575:Benzomorphans / Q000031:analogs & derivatives / Q000494:pharmacology*; D004174:Diprenorphine / Q000494:pharmacology; D004597:Electroshock; D009019:Morphinans / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects*; D017473:Receptors, Opioid, kappa
D001575:Benzomorphans; D009019:Morphinans; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D004174:Diprenorphine; D009270:Naloxone; C027247:MR 2266; C029552:Mr 1452