[Changes in testosterone levels in the testes of rat fetus after removal of the hypothalamus].
To specify the time of setting in of the hypothalamic control over testicular androgenous function in the prenatal development of rats, the brain hypothalamic area of 18.5-day-old fetuses was excised by encephalectomy in utero. Three days after the operation, i. e. on day 21.5 of the development, testosterone concentration in the testes was measured by radioimmunoassay. Testosterone concentration in the testes of encephalectomized fetuses was significantly decreased as compared with intact fetuses. Administration of LH-RH into the encephalectomized fetuses 2 hours prior to fixation removed the effect of encephalectomy on testosterone concentration in the testicular tissue. The data evidence the establishment of the hypothalamic control over androgenous function of the testes in rat fetuses at the end of the prenatal development.
D000818:Animals; D005260:Female; D005333:Fetus / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D007031:Hypothalamus / Q000196:embryology / Q000502:physiology* / Q000601:surgery; D008297:Male; D010903:Pituitary Gland, Anterior / Q000196:embryology / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000196:embryology / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism*
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone
Izmenenie kontsentratsii testosterona v semennikakh plodov krys posle udaleniia gipotalamusa.