Induction of diphtheria toxin-resistant mutants in human cells by halogenated compounds.
The mutagenic power of 1,2-dichloroethane, 1,2-dibromoethane, 1,2-diiodoethane was tested in the human cell line, EUE. In our mutagenic system, based on selection against diphtheria toxin, the halogenated compounds, 1,2-dichloroethane and 1,2-dibromoethane revealed a strong mutagenic effect, whereas 1,2-diiodoethane was not mutagenic at a concentration allowing survival of 41%.
D002460:Cell Line; D004167:Diphtheria Toxin; D004305:Dose-Response Relationship, Drug; D015946:Ethylene Dibromide / Q000494:pharmacology*; D005025:Ethylene Dichlorides / Q000494:pharmacology*; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000494:pharmacology*; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D004167:Diphtheria Toxin; D005025:Ethylene Dichlorides; D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated; D015946:Ethylene Dibromide