Pretreatment of mice with anti-IgD serum does not result in suppression of immune responsiveness induced by TNP-AECM-Ficoll or lipopolysaccharide.
Unlike the suppression of a primary response to a thymus-dependent antigen, pretreatment of mice with anti-IgD serum has no effect on the response to a thymus-independent (TI) antigen. It has also been shown that anti-IgD serum injected parenterally into mice 2 days previously, has no suppressive effect on non-specific responsiveness to an intraperitoneal injection of LPS. There is a similar lack of effect on the non-specific element of responsiveness to a TI antigen. These results provide in vivo confirmation of the results of previous in vitro experimentation.
D000818:Animals; D005362:Ficoll / Q000031:analogs & derivatives; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000008:administration & dosage / Q000494:pharmacology*; D007072:Immunoglobulin D / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D007106:Immune Sera; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; C026595:TNP-AECM-ficoll; D005362:Ficoll