title: [Subacute idiopathic polymyositis with rare antiribosomal antibodies in the serum - clinical course during immunosuppressive long-term therapy].
abstract: In a 66-year-old woman a polymyositis with subacute course was observed. The proof of very rare antiribosomal antibodies with a high titre on the serum was remarkable. Only after a cytostatic immunosuppressive therapy a clinical improvement developed, parallel to which there was a tendency to normalisation of immunological and enzyme-pathological parameters. The decrease of the titres of the autoantibodies is evaluated as indicators of the effectivity of the medicamentous immunosuppression and using the special literature is discussed in its importance also concerning the possibilites of the control of the clinical course.
mesh_terms: D000368:Aged; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D009220:Myositis / Q000276:immunology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D051381:Rats; D012270:Ribosomes / Q000276:immunology*
chemical_list: D000906:Antibodies; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone
vernacular_title: Subakute idiopathische Polymyositis mit seltenen antiribosomalen Antikörpern im Serum - Klinischer Verlauf unter immunsuppressiver Langzeittherapie.