Antilymphocyte autoantibody in lethal mouse malaria and its suppression by non-lethal malaria.
Mice infected with lethal P. berghei or P. yoelii malaria develop anti-lymphocyte autoantibodies less than a week after infection. The autoantibodies are IgM, T-dependent and cytotoxic to a subpopulation of non-T lymphocytes at 37 degrees C in the presence of mouse or guinea-pig complement. Non-lethal P. yoelii and P. chabaudi do not induce these autoantibodies. X-irradiated P. berghei parasites induce autoantibodies in normal mice but not in mice infected with non-lethal P. yoelii suggesting an active suppressor mechanism in the non-lethal infection.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D003602:Cytotoxicity, Immunologic; D007075:Immunoglobulin M / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology*; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010961:Plasmodium / Q000276:immunology; D010962:Plasmodium berghei / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination
D001323:Autoantibodies; D007075:Immunoglobulin M