title: Starvation stimulates pancreatic PGE content.
abstract: Recent evidence suggests that prostaglandins may exert a tonic inhibitory tone in the pancreatic beta cell during starvation. The effects of starvation on rat pancreatic prostaglandin E (PGE) content were studied. After 72 hrs of starvation, pancreatic PGE increased 250% above that of fed controls. Administration of streptozotocin, a selective beta-cell toxin, decreased pancreatic PGE significantly (p less than 0.005), but starvation partially reversed this trend. Thus, PGE may have a physiological role in modulating insulin secretion during starvation. It appears that both beta-cell and nonbeta-cell sources of PGE are involved in this phenomenon.
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation
chemical_list: D011458:Prostaglandins E; D007213:Indomethacin