title: Immunohistochemical localization of carcinoembryonic antigen in microglandular hyperplasia and adenocarcinoma of the endocervix.
abstract: Immunoperoxidase localization of carcinoembryonic antigen (CEA) was performed on tissue sections of microglandular hyperplasia and adenocarcinoma of endocervical origin to see if CEA would be a marker of malignancy in this context. Twenty (95%) of 21 of the benign lesions were negative and one was focally positive. Nine (64%) of 14 adenocarcinomas were widely positive, four were focally positive, and one was negative. These results suggest that extensive immunohistochemical positivity for CEA in endocervical glandular lesions is indicative of malignancy.
mesh_terms: D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002584:Cervix Uteri / Q000032:analysis / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism; D007124:Immunoenzyme Techniques; D002583:Uterine Cervical Neoplasms / Q000032:analysis / Q000473:pathology*
chemical_list: D002272:Carcinoembryonic Antigen