Metronidazole plus cefazolin versus cefazolin in gangrenous and perforated appendicitis in childhood--a prospective randomised trial.
59 children with gangrenous (n = 11) or perforated (n = 48) appendicitis underwent a prospective, randomized trial and received cefazolin or cefazolin plus metronidazole. Whereas postoperative abscesses developed in 44% of the controls, they were seen in 7% of the children who had received metronidazole (p less than 0.001). Relaparotomy for intestinal obstruction had to be performed in 11% and 13% of the cases respectively. The germ most frequently isolated from the abscesses was Bacteroides fragilis.
D001064:Appendicitis / Q000188:drug therapy* / Q000382:microbiology; D001065:Appendix / Q000473:pathology; D002437:Cefazolin / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005734:Gangrene; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation
D008795:Metronidazole; D002437:Cefazolin