[Activity of proteolytic enzymes in the kidney and blood serum of rabbits during implantation of different polyurethanes].
It is shown that the activity of neutral proteinase both in homogenate and in blood serum increases by the 14th day the D-1 sample being implanted. In the subsequent periods after implantation the enzyme activity in homogenate is the same. Three and six months after implantation the neutral proteinase activity in blood serum decreases as compared to the norm. The activity of acid proteinase in rabbit kidney homogenates lowers by the 90th day after implantation both for the D-1 and for A-10 samples. For the D-1 sample the enzyme activation in blood serum is observed by the 30th day after implantation, three months later it falls to reach the normal level in 6-12 months and inhibition activity on the 30th day after implantation on the A-10 sample. Such changes in the activity of enzymes in homogenates and blood serum may reflect certain stages of polyurethane biodestruction participation of various enzymic systems of the organism in these processes.
D000818:Animals; D004343:Drug Implants; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D010447:Peptide Hydrolases / Q000097:blood / Q000378:metabolism*; D011140:Polyurethanes / Q000633:toxicity*; D011817:Rabbits; D013329:Structure-Activity Relationship
D004343:Drug Implants; D011140:Polyurethanes; D010447:Peptide Hydrolases
Aktivnost' proteoliticheskikh fermentov pochek i syvorotki krovi krolikov pri implantatsii razlichnykh poliuretanov.