title: A controlled comparison of slow-release theophylline, ketotifen and placebo in the prophylaxis of asthma in young children.
abstract: A double blind crossover comparison of slow-release theophylline, ketotifen and placebo was carried out in 18 young children with perennial asthma. Theophylline significantly reduced symptoms and increased the mean peak expiratory flow rate. Transient nausea and vomiting was commoner during theophylline treatment but did not usually necessitate discontinuance of therapy.
mesh_terms: D000284:Administration, Oral; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007665:Ketotifen / Q000008:administration & dosage*; D008297:Male; D013806:Theophylline / Q000008:administration & dosage*
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline; D007665:Ketotifen