Corticotropin-releasing factor (CRF): mechanism to elevate mean arterial pressure and heart rate.
The efferent mechanisms by which central administration of corticotropin-releasing factor (CRF) elevates mean arterial pressure and heart rate were assessed in unanesthetized, unrestrained rats. CRF increased blood pressure and heart rate by stimulating noradrenergic sympathetic nervous outflow. CRF-induced cardiovascular changes were not dependent on anterior pituitary hormone release, adrenomedullary epinephrine secretion, the renin-angiotensin system or circulating vasopressin.
D000311:Adrenal Glands / Q000187:drug effects; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D007016:Hypophysectomy; D008297:Male; D051381:Rats; D012083:Renin / Q000502:physiology; D013564:Sympathetic Nervous System / Q000187:drug effects; D014667:Vasopressins / Q000502:physiology
D014667:Vasopressins; D000804:Angiotensin II; D003346:Corticotropin-Releasing Hormone; D012083:Renin