Severe oral hemorrhage and sepsis following bone marrow transplant failure.
Aplastic anemia is a failure of all the cellular components of the bone marrow and, untreated, usually results in death from bleeding and/or infection within 4 months. Treatment by bone marrow transplantation offers the only means of survival. When a bone marrow graft fails, the patient is extremely susceptible to severe infection and/or hemorrhage. In this case, a bone marrow transplantation in a 34-year-old white man with aplastic anemia failed. Among the medical problems that subsequently developed were severe, prolonged and life-threatening oral bleeding and infection.
D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D001424:Bacterial Infections / Q000209:etiology; D016026:Bone Marrow Transplantation; D005892:Gingivitis, Necrotizing Ulcerative / Q000209:etiology; D006084:Graft Rejection; D006801:Humans; D008297:Male; D006472:Oral Hemorrhage / Q000209:etiology*