title: [Anaphylactic reaction in cyclophosphamide infusion].
abstract: A number of drugs used in cancer chemotherapy have produced hypersensitivity reactions. Generalized urticaria to cyclophosphamide has been reported previously in 5 cases. We have recently observed a 25-year-old patient with M. Hodgkin who developed an anaphylactic shock immediately following an intravenous infusion of cyclophosphamide. Total serum IgE was significantly elevated (1280 U/ml). Using the epicutan skin testing highly positive papulo-vesicular reaction to cyclophosphamide was observed.
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000276:immunology; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D004359:Drug Therapy, Combination; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007428:Intradermal Tests
chemical_list: D007073:Immunoglobulin E; D003520:Cyclophosphamide
vernacular_title: Anaphylaktische Reaktion unter Cyclophosphamid-Infusion.