title: Membrane mechanisms in arterial hypertension.
abstract: The purpose of this review is to focus on alterations in vascular muscle membrane potentials (Em), ionic permeabilities, and ionic transport systems which may either contribute to or be a consequence of the hypertensive state. Three models of hypertension are discussed: 1) deoxycorticosterone-salt (DOCA-salt)-induced hypertension; 2) low-renin (presumably volume expanded) renal hypertension (LRRH); and 3) the spontaneously hypertensive rat (SHR) of the Okamoto-Aoki Kyoto-Wistar strain and its normotensive genetic control (WKY). The importance of studying all possible mechanisms of increased contraction in vascular smooth muscle is stressed.
mesh_terms: D000818:Animals; D001692:Biological Transport; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D006977:Hypertension, Renal / Q000378:metabolism; D066298:In Vitro Techniques; D007477:Ions / Q000378:metabolism; D008564:Membrane Potentials; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000503:physiopathology; D010539:Permeability; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride; D014661:Vasoconstriction
chemical_list: D007477:Ions; D003900:Desoxycorticosterone; D012965:Sodium Chloride