Ocular manifestations of graft-v-host disease.
Graft-v-host disease is the major complication of bone marrow transplantation for the leukemias and aplastic anemia. In the clinical evaluation of eye problems of patients with acute graft-v-host disease, findings reveal a disease process of keratoconjunctivitis that appears to represent a specific pathologic eye syndrome in which the conjunctivae and occasionally the cornea represent an immunologic target of graft-v-host disease. Additional studies of eye problems of chronic graft-v-host disease reveal the persistent nature of keratitis sicca and the morbid sequelae of the immunoincompetent patient.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003315:Cornea / Q000473:pathology; D006086:Graft vs Host Disease / Q000150:complications* / Q000209:etiology; D006087:Graft vs Host Reaction; D006801:Humans; D007637:Keratoconjunctivitis / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D014985:Xerophthalmia / Q000209:etiology