title: [Perioperative antibiotic prophylaxis in colon surgery. Metronidazole and tobramycin versus metronidazole alone. A prospective randomized study].
abstract: 97 patients scheduled to undergo elective surgery for colorectal carcinoma were randomized to receive either three doses of intravenous metronidazole-e and tobramycin or three doses of intravenous metronidazole alone. The first dose was given after induction of general anesthesia, the second at 9 p.m. and the third at 6 a.m. the following day. The study was double-blind, with patients in the metronidazol-alone group given a placebo infusion instead of tobramycin. The overall postoperative infection rate was 19.6% with no statistically significant difference between the two groups. It is concluded that the addition of an aminoglycoside does not afford better protection than prophylaxis with metronidazole alone.
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003106:Colon / Q000601:surgery*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D014031:Tobramycin / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D014031:Tobramycin
vernacular_title: Perioperative Antibiotikaprophylaxe in der Kolonchirurgie. Metronidazol und Tobramycin versus Metronidazol allein. Eine prospektive randomisierte Studie.