Ototoxicity of otic drops applied to the middle ear in the chinchilla.
Previous studies have shown that the application of topical otic drops to the external ear canals of animals with patent tympanostomy tubes may result in hearing impairment and cochlear hair cell loss. Otic drops are used in patients with tympanostomy tubes or tympanic membrane perforations and could have deleterious effects on the human membranous labyrinth. This report describes the inner ear damage that occurred after direct application of aminoglycoside-containing otic drops to the middle ears of experimental animals. The membranous labyrinths of 25 chinchillas were studied two days to five months after application of Cortisporin otic suspension (which contains neomycin, polymyxin B, hydrocortisone, and propylene glycol) to the middle ear cavity. Application of 0.5 ml of Cortisporin resulted in degeneration of all inner and outer hair cells throughout the cochlea, as well as severe damage to the stria vascularis. Moderate to severe degeneration of the vestibular receptor organs was also observed. The endolymphatic sacs showed dark-staining endolymph, cellular debris, and macrophages in the sac lumina, as well as increased activity of the epithelial lining.
D000818:Animals; D002682:Chinchilla / Q000502:physiology*; D002781:Cholesteatoma / Q000139:chemically induced; D004338:Drug Combinations / Q000009:adverse effects; D004427:Ear Diseases / Q000139:chemically induced; D007758:Ear, Inner / Q000187:drug effects* / Q000473:pathology; D004432:Ear, Middle / Q000473:pathology; D004712:Endolymphatic Sac / Q000187:drug effects / Q000473:pathology; D006854:Hydrocortisone / Q000009:adverse effects*; D008855:Microscopy, Electron, Scanning; D009355:Neomycin / Q000009:adverse effects*; D009925:Organ of Corti / Q000187:drug effects / Q000648:ultrastructure; D011112:Polymyxin B / Q000009:adverse effects*; D011113:Polymyxins / Q000009:adverse effects*; D012444:Saccule and Utricle / Q000187:drug effects / Q000473:pathology; D013316:Stria Vascularis / Q000187:drug effects / Q000473:pathology; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000473:pathology
D004338:Drug Combinations; D011113:Polymyxins; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone