title: Acute toxicity of 3-deoxy-4-sulphohexosulose in rats and mice, and in vitro mutagenicity in the Ames test.
abstract: 3-Deoxy-4-sulphohexosulose (DSH) is formed in sulphited foods by the interaction of SO2 and intermediates of the Maillard reaction. The acute intragastric toxicity of DSH has been studied in rats and mice, and the LD50 was found to exceed 5 g/kg body weight in both species. The only adverse effect seen in a 14-day post-dosing period was a transient diarrhoea in the first 24 hr. DSH was shown to be non-mutagenic in four strains of Salmonella typhimurium in the Ames test, with and without metabolic activation by S-9 mix from Aroclor-treated rats.
mesh_terms: D000818:Animals; D003837:Deoxy Sugars / Q000633:toxicity*; D003967:Diarrhea / Q000139:chemically induced; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009153:Mutagens; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D003837:Deoxy Sugars; D009153:Mutagens; C038611:3-deoxy-4-sulfohexosulose