Beta-lactam antibiotics resistant Rothia dentocariosa from infected postoperative maxillary cyst: studies on R-plasmid and beta-lactamase.
A cephalexin and penicillin G resistant strain of Rothia dentocariosa was clinically isolated from pus of infected postoperative maxillary cyst. The strain contained multiple plasmids. Plasmid curing tests with rifampicin eliminated cephalexin and penicillin G resistant phenotypic functions and 47 megadalton plasmids from the strain. Beta-Lactamase isolated from the strain hydrolyzed cephalosporin more efficiently than penicillin.
D000191:Actinomycetaceae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D000193:Actinomycetales Infections / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002506:Cephalexin / Q000494:pharmacology; D003560:Cysts / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D006801:Humans; D008443:Maxillary Sinus / Q000382:microbiology / Q000601:surgery; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D011815:R Factors; D012852:Sinusitis / Q000382:microbiology; D013530:Surgical Wound Infection / Q000382:microbiology; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D001618:beta-Lactamases; D002506:Cephalexin; D010400:Penicillin G