title: A double-blind controlled trial of metronidazole suppositories in children undergoing appendicectomy.
abstract: A total of 133 children, aged 16 months to 15 years (mean 6.7 years), with presumptive acute appendicitis, was included in a double-blind, placebo-controlled trial of the short-term (72 hour) use of metronidazole suppositories as prophylaxis against post-operative infection. There was no significant difference in the incidence or severity of wound infection or post-operative intra-abdominal sepsis between the metronidazole-treated and placebo groups. It is suggested that intra-rectal metronidazole, when used exclusively, is not sufficient for effective prophylaxis for appendicitis in childhood.
mesh_terms: D000293:Adolescent; D001062:Appendectomy; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D011292:Premedication; D011897:Random Allocation; D013488:Suppositories; D013530:Surgical Wound Infection / Q000517:prevention & control
chemical_list: D013488:Suppositories; D008795:Metronidazole