Biochemical and cytological studies of rat lung after inhalation of methanol vapour.
Rats were examined for changes at the lung surface and in lung tissue after inhalation of methanol vapour for up to 6 weeks at doses of up to 10 000 ppm. No significant changes were found in any of the parameters measured. Methanol vapour therefore does not appear to exert appreciable toxicity at these exposure levels towards rat lung.
D000818:Animals; D016282:Aspartic Acid Endopeptidases; D004247:DNA / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D010450:Endopeptidases / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D000432:Methanol / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D011663:Pulmonary Surfactants / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012260:Ribonucleases / Q000378:metabolism
D011663:Pulmonary Surfactants; D004247:DNA; D007770:L-Lactate Dehydrogenase; D012260:Ribonucleases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; D000432:Methanol