Prostaglandins in ocular pathophysiology with special reference to diabetic retinopathy and glaucoma.
This report reviews evidence for influences of prostaglandins (PGs) on intraocular pressure in glaucoma and on the progressive vascular and blood cell dysfunction in diabetes mellitus, of which retinopathy is a manifestation, and includes a brief outline of evidence for roles of PGs in ocular inflammation. Sequences in pathways of biosynthesis and conversion of PGs are summarized, and PG assay methods are evaluated briefly.
D000818:Animals; D001681:Biological Assay; D001791:Blood Platelet Disorders / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D004285:Dogs; D005123:Eye / Q000378:metabolism; D005901:Glaucoma / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D011453:Prostaglandins / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D011817:Rabbits
D011448:Prostaglandin Antagonists; D011453:Prostaglandins