title: Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part II-2. Subacute toxicity in rabbits.
abstract: Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to examine toxicological effects in male and female rabbits after repeated oral administration of MOM, non-crystalline solid, for 5 weeks at daily dosages of 400, 800, 1,600 and 3,200 mg/kg. In conclusion, the maximum non-toxic dosage level of MOM, non-crystalline solid, is presumed to be 400 mg/kg in male and female rabbits with p.o. administered once daily for 5 weeks.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D007933:Leucomycins / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D015644:Miocamycin; D009205:Myocarditis / Q000139:chemically induced; D011817:Rabbits
chemical_list: D007933:Leucomycins; D015644:Miocamycin