Investigations on the mutagenic activity of STS 557.
The progestin STS 557 was tested for mutagenic activity in the rec-type repair test with Proteus mirabilis, the Ames-test and the host-mediated assay with Salmonella typhimurium, the cytogenetic assays with ascites tumour and bone-marrow cells of mice and the dominant lethal test with male and female mice. All results obtained indicate the absence of a genotoxic activity of STS 557.
D000818:Animals; D001854:Bone Marrow Cells; D002875:Chromosomes / Q000187:drug effects; D004260:DNA Repair / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000633:toxicity; D045167:Progesterone Congeners / Q000633:toxicity*; D011513:Proteus mirabilis / Q000187:drug effects; D012475:Salmonella / Q000235:genetics
D009153:Mutagens; D045167:Progesterone Congeners; C023635:dienogest; D009277:Nandrolone