Effect of whole-body irradiation of mice on the number of background plaque-forming cells.
Mice were exposed in whole-body fashion to several doses of radiation and killed at various times thereafter for a determination of the number of background plaque-forming cells (PFCs) as assayed on either sheep erythrocytes or bromelain-treated autologous mouse erythrocytes. Increased numbers of both types of PFC were found in the irradiated groups. These increases were dependent on radiation dose and time after exposure. They did not appear to be caused by a disruption of normal lymphocyte traffic or a switch in immunoglobulin isotype. An increased number of PFCs on bromelain-treated mouse RBCs but not on sheep RBCs were found in irradiated congenitally athymic nude mice. On the basis of this and related observations, background PFCs on bromelain-treated mouse RBCs and on sheep RBCs appear to fall under different forms of homeostatic control.
D000818:Animals; D000921:Antibody-Producing Cells / Q000528:radiation effects*; D001854:Bone Marrow Cells; D001963:Bromelains / Q000494:pharmacology; D005260:Female; D006462:Hemolytic Plaque Technique; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology / Q000528:radiation effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D010581:Peyer's Patches / Q000166:cytology; D013154:Spleen / Q000166:cytology; D014916:Whole-Body Irradiation
D001963:Bromelains