Evidence for the existence of a family of biologically active angiotensin I-like peptides in the dog central nervous system.
A family of angiotensin I-like peptides has been derived from endogenous precursors present in dog cerebrospinal fluid after incubation with species homologous renin. These peptides are immunologically and pharmacologically similar to [Ile5]angiotensin I, and have molecular weights ranging between 1300 and 2200 daltons. The presence of precursors in the cerebrospinal fluid able to generate various biologically active angiotensin I-like peptides dissimilar to plasma angiotensin I supports the concept of a local angiotensin I-forming system in the brain.
D000803:Angiotensin I / Q000502:physiology*; D000809:Angiotensins / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D004285:Dogs; D008970:Molecular Weight; D010455:Peptides / Q000302:isolation & purification; D012083:Renin / Q000502:physiology
D000809:Angiotensins; D010455:Peptides; D000803:Angiotensin I; D012083:Renin