[N-acylated derivatives of cyclohexylaniline with potential antiallergic and analgesic-antiinflammatory activity].
Some N-acylated derivatives of cyclohexylaniline were prepared. These can be considered as derived from oxarbazol (A), a carbazolic structure with antiallergic activity, by breaking the bond between carbon atom 4a and 4b. In the new molecule the following groups were introduced: benzoic acid, salicylic acid, acetylsalicylic acid and tetrazol. The synthesized compounds were studied for analgesic, antiedema and antiallergic activity. Some showed analgesic action (phenylquinone) comparable with that of naproxen. Antiinflammatory activity was slight and antiallergic activity nonexistent.
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000188:drug therapy; D005260:Female; D006633:Histamine Antagonists / Q000138:chemical synthesis*; D006967:Hypersensitivity / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D011919:Rats, Inbred Strains
D000814:Aniline Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006633:Histamine Antagonists; C028146:4-cyclohexylaniline
Derivati N-acilati della cicloesilanilina a potenziale attività analgesico-antiinfiammatoria e antiallergica.