A controlled study of the exocrine pancreatic function in Sjögren's syndrome and rheumatoid arthritis.
The exocrine pancreatic function has been estimated using the N-benzoyl-L-Tyrosyl para-amino-benzoic acid test (NBT PABA test) and by measuring the trypsinemia by radio-immunoassay (RIA trypsinemia) in nonselected cases of Sjögren's syndrome (SS) and seropositive rheumatoid arthritis (RA) in comparison with normal controls. The NBT PABA test was pathological in 37,5% of SS and 35% of RA patients but in none of the controls. The RIA trypsinemia was found to be high in 6,2% of SS and 45% of RA patients. These findings suggest that exocrine pancreatic function is impaired in some SS and RA cases. However, this exocrine pancreatic defect was clinically silent in all patients.
D010129:4-Aminobenzoic Acid; D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000503:physiopathology*; D010186:Pancreatic Function Tests; D011863:Radioimmunoassay; D012859:Sjogren's Syndrome / Q000503:physiopathology*; D014357:Trypsin / Q000097:blood; D062366:para-Aminobenzoates
D062366:para-Aminobenzoates; C006717:bentiromide; D014357:Trypsin; D010129:4-Aminobenzoic Acid