title: [Modeling the effects of radiation damage to DNA and the genetic risk of radionuclide decay. Dehydrogenation of pyrimidine nucleotides during decay of incorporated 3H].
abstract: Dehydrogenation of DNA pyrimidine nucleotides in thymine positions 5 and 6 and cytosine position 5 is not a drastic lethal damage. Moreover, dehydrogenation of DNA in thymine positions 5 and 6 is not an effective mutagenic lesion. DNA dehydrogenation in cytosine position 5 has proved to be a pronounced mutagenic damage. As to induction of point mutations, 3H is not more harmful than external gamma-radiation given in equivalent doses.
mesh_terms: D004271:DNA, Fungal / Q000528:radiation effects; D003843:Deoxycytidine Monophosphate / Q000528:radiation effects*; D003845:Deoxycytosine Nucleotides / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D009154:Mutation; D009694:Nucleic Acid Precursors / Q000528:radiation effects; D012441:Saccharomyces cerevisiae / Q000528:radiation effects; D013938:Thymidine Monophosphate / Q000528:radiation effects*; D013942:Thymine Nucleotides / Q000528:radiation effects*; D014316:Tritium
chemical_list: D004271:DNA, Fungal; D003845:Deoxycytosine Nucleotides; D009694:Nucleic Acid Precursors; D013942:Thymine Nucleotides; D014316:Tritium; D003843:Deoxycytidine Monophosphate; D013938:Thymidine Monophosphate
vernacular_title: Modelirovanie éffektov radiatsionnykh povrezhdeniĭ DNK i geneticheskaia opasnost' raspada radionuklidov. Degidrirovanie pirimidinovykh nukleotidov pri raspade inkorpororovannogo 3H.