RII-RIII chloroquine resistant Plasmodium falciparum malaria from East Africa: studies of the in vivo and in vitro response to chloroquine.
A case is reported of Plasmodium falciparum malaria from East Africa resistant to chloroquine in the in vivo test at the RII level. Serum chloroquine concentrations and the in vitro test indicated RIII resistance. The need for further comparative studies of parasitaemia, serum chloroquine concentration and in vitro chloroquine sensitivity assessment is emphasized.
D000328:Adult; D000351:Africa, Eastern; D002738:Chloroquine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D006801:Humans; D008288:Malaria / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects
D002738:Chloroquine