title: Glycosaminoglycans and the control of cell surface proteinase activity.
abstract: It is postulated that the metabolically variable fine structure of pericellular heparan glycosaminoglycans affects the ability of these molecules to influence cell proliferation-associated proteinase-catalysed reactions occurring at cell surfaces. Evidence suggesting the possibility of a wide repertoire of glycosaminoglycan-mediated positive and negative effects on such reactions is reviewed. It is suggested that clinical administration of compounds related chemically to heparins might usefully modulate cell proliferation-associated proteinase activity.
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002477:Cells / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002642:Chick Embryo; D010450:Endopeptidases / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D006494:Heparin Antagonists / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008970:Molecular Weight; D011480:Protease Inhibitors / Q000378:metabolism / Q000494:pharmacology; D051381:Rats
chemical_list: D006025:Glycosaminoglycans; D006494:Heparin Antagonists; D011480:Protease Inhibitors; D000990:Antithrombin III; D006493:Heparin; D010450:Endopeptidases