Gastric antral ulcers produced by the combined administration of indomethacin with 2-deoxy-D-glucose in the rat.
The influence of 2-deoxy-D-glucose (2DG) on indomethacin ulcers was studied in rats. 2DG (200 mg/kg i.v.) produced large round ulcers in the lesser curvature of the antrum and aggravated lesions of the corpus 6 h after treatments in indomethacin (40 mg/kg i.p.)-treated rats. Insulin (5 units/kg i.v.) also produced gastric antral ulcers similarly to 2DG. Antral ulcers were revealed rather clearly 48 h after the administration of indomethacin and 2DG when the corpus lesion index was reduced. 2DG or insulin had only a slight influence on the severity of other experimental gastric ulcers. Peripheral gastric secretagogues, bethanechol (1 mg/kg s.c. X 2) or histamine (10 mg/kg s.c. X 2) did not produce antral ulcers at the gastric secretory dose in the indomethacin-treated rats. High doses of atropine (1.0 and 10 mg/kg s.c.) prevented gastric antral ulcers. The combined administration of indomethacin with 2DG produced gastric antral ulcers similar to human gastric ulcers in rats. The combination of gastric acid secretion, vagus nerve stimulation and some other factors may be involved in gastric antral ulcers produced in rats.
D000818:Animals; D003837:Deoxy Sugars / Q000633:toxicity*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000633:toxicity*; D004347:Drug Interactions; D005744:Gastric Acid / Q000378:metabolism; D007213:Indomethacin / Q000008:administration & dosage / Q000633:toxicity*; D007328:Insulin / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D011706:Pyloric Antrum; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology
D003837:Deoxy Sugars; D007328:Insulin; D003847:Deoxyglucose; D007213:Indomethacin