Antiinflammatory properties of a series of 4-amino-5-arylpyrazoles.
A series of ethyl 4-amino-5-arylpyrazol-3-yl carboxylates were prepared from arylacetonitriles and ethyl diazoacetate. The compounds were evaluated for their analgesic and antiinflammatory properties, that were not, however, sufficiently interesting to justify the further development of the compounds. The synthesis of the compounds could be a useful extension of the original report by A. Bertho on the reaction between ethyl cyanoacetate and ethyl diazoacetate to yield diethyl 4-aminopyrazole-3,5-dicarboxylate.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles