title: A 21-day double-blind study of the effect of adding sustained-release theophylline (Nuelin SA) to inhaled salbutamol in patients with asthma.
abstract: The effect of adding sustained-release theophylline tablets (Nuelin SA) in a dose of 350 and 700 mg daily to regular treatment with inhaled salbutamol was assessed in a double-blind cross-over study in 19 patients with reversible airways obstruction. In this combination, oral theophylline, even in the relatively low dose of 350 mg a day, produced a significant additional improvement in lung function. Subjectively, patients showed a preference for the combination of theophylline and inhaled salbutamol compared with the beta-stimulant alone.
mesh_terms: D000328:Adult; D000368:Aged; D000420:Albuterol / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D013806:Theophylline / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline; D000420:Albuterol