Statistical study on fulminant liver disease in Japan.
Autopsy cases of fulminant liver disease, a pathological group of hepatic lesions which correspond to the clinical entity of fulminant hepatic failure, were collected from the 'Annual of the Pathological Autopsy Cases in Japan' (1969-1978) and analyzed. The total number of cases reviewed in this paper was 239,414, among which 1,000 (0.42%) were considered to match the above category of hepatic disease. Further analysis was carried out on these 1,000 cases, and the results were as follows. Clinical and pathoanatomical diagnoses which had actually been given in these cases covered a wide range. The incidence showed no chronological change or geographical variation in Japan. The age of patients was distributed widely, and there was no sex difference in incidence. Concerning the occupation or background of patients, a considerable number were medical and paramedical personnel. The liver weight was less than normal in most cases, but there were some exceptional cases in which the liver was found to be hypertrophied. As complications many kinds of lesions were found in various organs of the body; hemorrhage, acute inflammation, and necrosis of various viscera were noticed in many cases.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006501:Hepatic Encephalopathy / Q000473:pathology; D006505:Hepatitis / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009929:Organ Size