Possibilities of preventing otitis media by vaccination.
The prerequisites for preventing a considerable proportion of acute otitis media (AOME) of children are theoretically good--pneumococcal types/groups present in the available 14-valent pneumococcal capsular polysaccharide vaccine are the most common bacteria in AOME, and a good serum antibody response is followed by type-specific protection from infection. However, the four most common types/groups (= 2/3 of all pneumococci in AOME) have very poor immunizing capacity in infants, and therefore the vaccine offers little protection from AOME for children under the age of 2 years. This information should help towards an improved new vaccine for AOME.
D000208:Acute Disease; D000367:Age Factors; D001428:Bacterial Vaccines / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006801:Humans; D007223:Infant; D010033:Otitis Media / Q000517:prevention & control*; D010034:Otitis Media with Effusion / Q000276:immunology / Q000517:prevention & control*; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines; D012008:Recurrence; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
D001428:Bacterial Vaccines; D022242:Pneumococcal Vaccines