Peripheral blood and bone marrow lymphocytes of B chronic lymphocytic leukaemia patients.
The percentages of lymphocytes subpopulations were assessed in the peripheral blood and bone marrow of B chronic lymphocytic leukaemia patients with monoclonal antibodies and flow cytometry. The absolute number of peripheral T cells is higher compared to healthy subjects; the imbalance of OKT 4 and OKT 8 positive subsets in peripheral blood is characterized by an inversion of the T 4/T 8 ratio. T 4 positive cells are predominant in the bone marrow; the Leu 7 positive population is increased in absolute numbers. These precocious phenomena could be important in the immunodeficiency associated with B CLL and/or in the progression of the disease.
D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes; D001854:Bone Marrow Cells; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000276:immunology; D008297:Male; D013601:T-Lymphocytes / Q000145:classification*
D000911:Antibodies, Monoclonal