Melatonin and the pituitary response to GnRH in prepubertal and adult ewes.
GnRH-induced LH-release was studied in female lambs from 5 weeks of age until puberty and in adult anoestrous ewes. In pre-pubertal animals LH was released rapidly after GnRH treatment but after puberty the responses became slower and more sustained although the peak concentration did not change. In neither pre-pubertal nor adult sheep did prior treatment with melatonin influence LH release after GnRH treatment.
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008550:Melatonin / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D012741:Sexual Maturation; D012756:Sheep
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D008550:Melatonin