title: Investigations on the presence of papova virus in certain forms of human cancer. Note 2. Brain tumors.
abstract: Two serially transmissible tumors (metastatic lymphosarcomas) were induced in the hamster by inoculation of human brain tumor material--tissue homogenate from a malignized fibroma or DNA extracted from a meningioma. SV40 V antigen was made evident by indirect immunofluorescence in 4 out of 18 human tumors, while SV40 T antigen could only be demonstrated in the tumors experimentally induced in hamsters. Antibodies to SV40 T antigen were detected in 12 out of 60 patients with different tumors, in 1 out of 40 blood donors and in 7 out of 18 hamsters carrying experimentally induced tumors.
mesh_terms: D000328:Adult; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D000957:Antigens, Viral, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000276:immunology*; D006224:Cricetinae; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D009368:Neoplasm Transplantation; D027383:Papillomaviridae / Q000276:immunology; D027382:Polyomaviridae; D013539:Simian virus 40 / Q000276:immunology; D013997:Time Factors; D014412:Tumor Virus Infections / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000957:Antigens, Viral, Tumor