[Comparative immunomorphological study of the immunogenic activity of dysentery vaccines produced by different methods].
The morphological study of the ophthalmic mucosa of guinea pigs immunized locally with different dysentery vaccines has demonstrated the advantages of live dysentery vaccine prepared from Shigella sonnei 6S over heated vaccine and Shigella antigen extracts. The protective properties of dysentery vaccines, their capacity for protecting the mucous membrane from the penetration and intracellular multiplication of shigellae correlates with the degree of the manifestation of vaccine-induced plasmatocellular reaction in the epithelial and subepithelial zones. The importance of the virulence of the strains used for the preparation of vaccines, as well as the method of their preparation, for the immunogenic potency of vaccines is shown.
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000302:isolation & purification; D003228:Conjunctiva / Q000276:immunology / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D004405:Dysentery, Bacillary / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D006168:Guinea Pigs; D007109:Immunity; D007114:Immunization / Q000379:methods; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology; D012764:Shigella sonnei / Q000276:immunology* / Q000472:pathogenicity; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000276:immunology / Q000302:isolation & purification; D014774:Virulence
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated
Sravnitel'noe immunomorfologicheskoe izuchenie immunogennoĭ aktivnosti dizenteriĭnykh vaktsin razlichnogo sposoba izgotovleniia.