Occurrence of gamma-trace in the calcitonin-producing C-cells of simian thyroid gland and human medullary thyroid carcinoma.
gamma-Trace, a microprotein occurring in neuroendocrine cells, was demonstrated by immunohistochemical technique to be present in the calcitonin-producing C-cells of normal simian thyroid gland and of human medullary thyroid carcinoma. A comparatively high concentration of gamma-trace was demonstrated in tissue extract of neoplastic C-cells. The immunoreactive protein found in the extract had a molecular weight and electrophoretic mobility characteristic for gamma-trace.
D000327:Adsorption; D000818:Animals; D002116:Calcitonin / Q000378:metabolism*; D002522:Chlorocebus aethiops; D055316:Cystatin C; D015891:Cystatins; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005916:Globulins / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007106:Immune Sera; D007122:Immunoelectrophoresis; D007124:Immunoenzyme Techniques; D013961:Thyroid Gland / Q000166:cytology / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism*
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D005916:Globulins; D007106:Immune Sera; D013006:Growth Hormone; D002116:Calcitonin