Antibody formation by one or both lymphoid populations present in chimeric marmosets.
Development of an isoimmune serum capable of identifying a specific leukocyte antigen in the marmoset, Saguinus fuscicollis illigeri, permitted detection of lymphoid cell chimerism in this species by the cytotoxic test. This reagent was then used to identify the cell population in the chimera responsible for antibody production against a test antigen, sheep red blood cells. Primary in vitro antibody formation as measured by plaque-forming cells with blood leukocytes or splenic lymphocytes of six animals chimeric for the leukocyte antigen, MLA-1, revealed an immune response by both cell types of the chimeric population from three animals and a response by only one cell type in the other three.
D000818:Animals; D000917:Antibody Formation; D002678:Chimera; D006462:Hemolytic Plaque Technique; D006649:Histocompatibility Antigens / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology*; D012452:Saguinus
D006649:Histocompatibility Antigens