Ineffective erythropoiesis in acute human P. falciparum malaria.
An analysis of erythroblast cell kinetics utilizing quantitative 14C-autoradiography has been performed in five cases of acute Plasmodium falciparum malaria prior to and, in four patients, 3 or 6 days after the onset of antimalarial therapy. Associated with no or only moderate anemia were changes of erythroblast morphology, a considerable shift in the frequency of red and white blood cell precursors in the bone marrow, and a reduced rate of erythroblast proliferation. There was a marked loss of polychromatic erythroblasts, which was smaller but still detectable during the therapeutic phase. The results provide some quantitative data on the extent of "parenchymal damage" of bone marrow and stress the impact of ineffective erythropoiesis and reduced rate of erythropoietic proliferation on the emergence of anemia in Plasmodium falciparum malaria.
D000208:Acute Disease; D001345:Autoradiography; D001856:Bone Marrow Examination; D002452:Cell Count; D002738:Chloroquine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004912:Erythrocytes / Q000276:immunology; D004920:Erythropoiesis; D006412:Hematopoietic Stem Cells; D006801:Humans; D008288:Malaria / Q000097:blood* / Q000188:drug therapy; D010587:Phagocytosis; D010963:Plasmodium falciparum
C023676:chloroquine diphosphate; D002738:Chloroquine