title: Immunohistologic study of cellular populations of histiocytofibromas ("dermatofibromas").
abstract: Histiocytofibromas (HF) are benign tumours of the skin, the cellular composition of which is not yet known with certainty. The immunohistologic characteristics of 5 lesions were studied by using monoclonal antibodies and an indirect immunofluorescence method. All tumours were found to contain HLA-DR(+) cells, and, to a minor degree, OKM1(+) cells. OKT6(+) cells were present in the epidermis overlying the tumours; however in the HF themselves, no OKT6(+) cells were found. The presence of HLA-DR(+) and OKM1(+) cells demonstrates that HF contain cells bearing antigenic characteristics of histiocytes but not of Langerhans' cells, and we feel that the term "histiocytofibroma" is a more accurate designation for these lesions than "dermatofibroma".
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis; D005350:Fibroma / Q000276:immunology / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens; D018219:Histiocytoma, Benign Fibrous / Q000276:immunology / Q000473:pathology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II