title: Amish study, IV: Genetic linkage study of pedigrees of bipolar probands.
abstract: Genetic linkage studies were conducted on five Old Order Amish bipolar pedigrees in 1979 and 1982, with 94 members tested for color blindness and typed for 42 red blood cell and related markers in 17 antigen systems. Also, 59 individuals in two pedigrees were typed for HLA, Bf, and GLO. Linkage analyses assuming X-linkage and autosomal inheritance of bipolar illness were done with diagnostic schemes ranging from strict bipolar to milder forms of affective disorder. Linkage to affective disorders was not strongly supported for any marker locus. Close linkage to HLA was excluded, with weaker evidence against linkage to GLO.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics*; D001789:Blood Group Antigens / Q000235:genetics; D002648:Child; D003117:Color Vision Defects / Q000235:genetics; D011415:Complement Factor B / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics; D005006:Ethnicity; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics; D010375:Pedigree
chemical_list: D001789:Blood Group Antigens; D005819:Genetic Markers; D006680:HLA Antigens; D011415:Complement Factor B; D007791:Lactoylglutathione Lyase