Fatty acids and the control of bilirubin levels in blood.
The evidence that changes in the hepatic intracellular concentration of non-esterified fatty acids affect the clearance of bilirubin from blood by the liver is reviewed. Such a mechanism would in particular explain the rise in plasma bilirubin levels during fasting.
D000818:Animals; D001663:Bilirubin / Q000097:blood* / Q000378:metabolism; D005215:Fasting / Q000009:adverse effects; D005230:Fatty Acids, Nonesterified / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000097:blood* / Q000378:metabolism; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008895:Milk, Human / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011911:Rats, Gunn
D005230:Fatty Acids, Nonesterified; D001663:Bilirubin