title: Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part VI-1. Acute toxicity in infant mice in comparison with young adult mice.
abstract: Sutherland and Weiss et al. reported cases of newborn human deaths or Gray syndrome after overdosage of chloramphenicol. In general, it has been reported that the acute toxicities of drugs are enhanced in immature animals compared with adult animals. The objective of this study was to determine the LD50 values in infant (5-day-old) and young adult (5-week-old) male and female mice after single subcutaneous and oral administration of MOM, non-crystalline solid and to estimate the toxicity ratio of those LD50 values. LD50 values of MOM, non-crystalline solid, were more than 5,000 mg/kg and the lethal toxicity was the same in infant and adult mice. Toxicity ratios were not obtained.
mesh_terms: D000367:Age Factors; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D005260:Female; D007928:Lethal Dose 50; D007933:Leucomycins / Q000633:toxicity*; D008297:Male; D051379:Mice; D015644:Miocamycin
chemical_list: D000900:Anti-Bacterial Agents; D007933:Leucomycins; D015644:Miocamycin