Ciclazindol: an oral agent with weight reducing properties and hypoglycaemic activity.
In a single blind crossover study, ciclazindol, 10-(m-chlorophenyl)-2, 3, 4, 10-tetrahydropyrimide (1, 2 alpha) indol-10-ol hydrochloride (Fig. 1), has been found to have hypoglycaemic action, and to produce reduction in appetite and weight. The mode of action appears to be different from either biguanides or sulphonylureas. Side-effects were few and mild. Metformin 500 mg b.d. had comparable hypoglycaemic effect but did not suppress appetite. Ciclazindol may be useful as a mild oral hypoglycaemic agent for obese patients, and would be suitable for once daily administration.
D000328:Adult; D000368:Aged; D001067:Appetite Depressants; D001835:Body Weight; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents; D007211:Indoles / Q000009:adverse effects / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D008055:Lipids / Q000097:blood; D008297:Male; D008687:Metformin / Q000494:pharmacology; D008875:Middle Aged; D009765:Obesity
D001067:Appetite Depressants; D007004:Hypoglycemic Agents; D007211:Indoles; D007328:Insulin; D008055:Lipids; D008687:Metformin; C009990:ciclazindol