title: Performance evaluation of SPRINT, a single photon ring tomography for brain imaging.
abstract: SPRINT, a prototype single photon tomograph, has been designed primarily for high-resolution brain imaging in humans with I-123-labeled compounds such as iodoamphetamine, hydroxyiodopropyldiamine (HIPDM), and iodobenzene (IBZ). SPRINT uses a ring of stationary, discrete Nal detectors, and fan-beam sampling is accomplished with a rotating eight-slit aperture ring that acquires a complete projection set in 1/8 revolution. In-plane and cross-plane resolutions are 8mm and 10mm FWHM, respectively, measured on axis. Sensitivity with an 18% energy window is 1000 cprs per microCi/cc for Tc-99m in a 20 cm diameter phantom. A detailed evaluation of system performance has been completed, and preliminary human brain blood flow images have been obtained using HIPDM.
mesh_terms: D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D005069:Evaluation Studies as Topic; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013667:Technetium; D013679:Technology, Radiologic; D014055:Tomography, Emission-Computed / Q000295:instrumentation* / Q000379:methods
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013667:Technetium; C036739:N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine