[Trial of cholinesterase reactivators as proserine antagonists].
HI-6 and TMB-4 were the most effective and safe of 7 cholinesterase reactivators tested as agents for the prophylaxis of proserine poisoning of male mice. The reactivator HI-6 strongly potentiated the prophylactic efficacy of a mixture of atropine and arpenal administered in the doses sufficient for the blockade of both the m- and h-cholinoreactive systems of mice. As demonstrated by experiments in vitro, HI-6 and TMB-4 did not reacivate proserine-inhibited cholinesterase. The natural anticholinesterase activity of HI-6 was negligible. Based on the correlation of the data obtained to the reported data indicating that HI-6 has a low ganglioblocking activity it is inferred that the direct effect on the receptor is of no importance for the potentiating effect. It is assumed that HI-6 modulates the cholinoreactive systems, which leads to a dramatic increase of the efficacy of cholinolytics.
D000818:Animals; D000931:Antidotes; D001285:Atropine / Q000627:therapeutic use; D002074:Butanones / Q000627:therapeutic use; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D004158:Diphenylacetic Acids / Q000627:therapeutic use; D004357:Drug Synergism; D008297:Male; D051379:Mice; D009388:Neostigmine / Q000506:poisoning*; D009768:Obidoxime Chloride / Q000627:therapeutic use; D010091:Oximes; D010276:Parasympatholytics / Q000627:therapeutic use; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D011726:Pyridinium Compounds / Q000627:therapeutic use; D014289:Trimedoxime / Q000627:therapeutic use
D000931:Antidotes; D002074:Butanones; D002801:Cholinesterase Reactivators; D004158:Diphenylacetic Acids; D010091:Oximes; D010276:Parasympatholytics; D011220:Pralidoxime Compounds; D011726:Pyridinium Compounds; C003027:HS 6; C012616:HS 3; C017442:isonitrozine; C006631:arpenal; D009388:Neostigmine; D009768:Obidoxime Chloride; D014289:Trimedoxime; D001285:Atropine; C020165:HGG 12; C022870:asoxime chloride
Ispytanie reaktivatorov kholinésterazy kak antagonistov prozerina.