Effect of hydrazide cysteine on T cells. I. Hydrazide cysteine changes the sensitivity of murine T lymphocytes to hydrocortisone and their ability to form autologous rosettes.
Immunotropic properties of hydrazide cysteine (HD) were studied in vivo and in vitro using mouse thymocytes, splenocytes and peripheral non-B lymphocytes (PBL). HD in the doses used, was not cytotoxic, increased resistance to HC of all cells examined and caused an elevation of ARFC levels in thymocytes and splenocytes being inhibitory in relation to PBL. HD, after in vitro contact with PBL induced differentiation of precursor cells into Lyt 2+ lymphocytes.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D007518:Isoantibodies; C029805:Lyt antibodies; C025196:cysteine hydrazide; D003545:Cysteine; D006854:Hydrocortisone