title: General kinetic and dynamic principles and their application to continuous infusion anaesthesia.
abstract: The use of intravenous anaesthetic agents by continuous infusion requires knowledge of their pharmacokinetic properties. In this article, the general pharmacokinetic principles behind the use of infusions of intravenous agents are presented and the literature with regard to the individual drugs used in this way is reviewed.
mesh_terms: D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000378:metabolism; D000771:Anesthesia, Intravenous / Q000379:methods; D000777:Anesthetics / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D005045:Etomidate / Q000378:metabolism; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007263:Infusions, Parenteral; D007700:Kinetics; D008433:Mathematics; D008723:Methohexital / Q000378:metabolism; D008875:Middle Aged; D008954:Models, Biological; D010636:Phenols / Q000378:metabolism; D011280:Pregnanolone / Q000031:analogs & derivatives / Q000378:metabolism; D015742:Propofol; D051381:Rats; D013874:Thiopental / Q000378:metabolism
chemical_list: D000777:Anesthetics; D006993:Hypnotics and Sedatives; D010636:Phenols; C020413:minaxolone; D000530:Alfaxalone Alfadolone Mixture; D011280:Pregnanolone; D008723:Methohexital; D013874:Thiopental; D015742:Propofol; D005045:Etomidate