Effects of leucovorin and methylcobalamin with N2O anesthesia.
Results of the deoxyuridine suppression test, a good marker for defining biochemical megaloblastosis caused by deficiency of folate and vitamin B12, became abnormal (greater than 10%) after 6 hours of administration of nitrous oxide anesthesia. 5-Formyltetrahydrofolate and methylcobalamin administration during nitrous oxide anesthesia have no remarkable effect on the correction of deoxyuridine suppression test values. On the other hand, 5-formyltetrahydrofolate and methylcobalamin administrated at the end of nitrous oxide anesthesia corrected the abnormal deoxyuridine suppression test values nearly to normal range within 1 hour.
D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D003857:Deoxyuridine / Q000378:metabolism; D005492:Folic Acid / Q000097:blood; D006801:Humans; D002955:Leucovorin / Q000097:blood / Q000494:pharmacology*; D009609:Nitrous Oxide / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
D004247:DNA; D005492:Folic Acid; C019476:mecobalamin; D009609:Nitrous Oxide; D014805:Vitamin B 12; D002955:Leucovorin; D013936:Thymidine; D003857:Deoxyuridine