Possible role of enteric organisms in the pathogenesis of ankylosing spondylitis and other seronegative arthropathies.
One-hundred eighty-five clinical isolates of Salmonella sp., Shigella sp., Escherichia coli, and Campylobacter sp. were tested for their ability to absorb the lymphocytotoxic activity of an antiserum (anti-Klebsiella sp. K43) directed against a specific HLA-B27-associated cell surface determinant on the lymphocytes of patients with ankylosing spondylitis (AS). Seven of these isolates (three Salmonella sp., two Shigella sp., one E. coli, and one Campylobacter sp.) were found to cross-react with the B27-positive cells of AS patients (B27+ AS+); an E. coli organism isolated from the rectal swab of an HLA-B27-negative clinically normal individual also cross-reacted with B27+ AS+ cells. These cross-reactive enteric organisms elaborate a factor (modifying factor) which specifically modifies the B27-positive lymphocytes of normal individuals; this factor is structurally and antigenically related to a functionally similar factor secreted by certain isolates of Klebsiella sp. These data suggest that certain enteric organisms share a common determinant which cross-reacts with B27+ AS+ cells. It is suggested that this cross-reactivity is somehow related to an early event in the pathogenesis of AS and possibly of other seronegative arthropathies.
D002850:Chromatography, Gel; D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D004755:Enterobacteriaceae / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D004756:Enterobacteriaceae Infections / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D007163:Immunosorbent Techniques; D008214:Lymphocytes / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000209:etiology* / Q000382:microbiology