title: Fibrous histiocytomas of the oral and maxillofacial regions.
abstract: Fibrous histiocytomas of the oral and maxillofacial regions are rare. The present study analyzes a sample of 63 cases from the literature together with 7 personally observed cases. Age, sex, site, size, clinical behaviour, treatment and survival were evaluated and related to a histological classification based on that of Rosai (1981). Lesions were assessed for histological criteria which would place them in one of 2 groups: fibrous histiocytoma (FH) or pleomorphic fibrous histiocytoma (PFH). Within these 2 histological groups the cases were subdivided into clinically benign, aggressive or malignant lesions. Thirty-nine cases (56.0%) were classified as FH and 31 cases (44.0%) as PFH. The mean age of male patients with PFH was significantly higher than female patients with FH (t = 3.05; d.f. 37; p less than 0.0025). Lesions in the PFH group involved bone more frequently than those in the FH group (Yate's Chi2 = 16.66; d.f. 1; p less than 0.00025). Lesions involving bone for both histological groups were more likely to be aggressive or malignant than soft-tissue lesions (Yate's Chi2 = 29.9; d.f. 1; p less than 0.00025). Soft-tissue lesions were usually less than 5 cm in greatest diameter. Radiographic features of malignancy for lesions with bone involvement is of prognostic importance regardless of the histological appearance of the lesion. The majority of the lesions under study were from the deep tissues of the oral and maxillofacial regions.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005147:Facial Bones / Q000473:pathology*; D005153:Facial Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000628:therapy; D009362:Neoplasm Metastasis; D011379:Prognosis; D012888:Skull Neoplasms / Q000473:pathology* / Q000628:therapy