pH-control via secretin or antacid: prophylaxia of stress ulcers in high-risk surgical patients.
The efficacy of an antacid or synthetic secretin in elevating the intragastric pH above 4 was tested in a controlled, prospective study. Twenty-one high-risk surgical patients received an antacid and 17 secretin. Antacid prophylaxis resulted in a significantly higher intragastric pH than with secretin. This was especially true in patients with several risk factors. The percent of secretin patients with a pH below 4 was higher. An increase in dosage was necessary in 4 of the 17 patients receiving secretin and in none of those receiving antacids. One stress ulcer hemorrhage occurred during secretin prophylaxis.
D000368:Aged; D000863:Antacids / Q000627:therapeutic use*; D005744:Gastric Acid; D005750:Gastric Juice / Q000187:drug effects; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D012633:Secretin / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological / Q000517:prevention & control; D013514:Surgical Procedures, Operative
D000863:Antacids; D012633:Secretin