Influence of heat on insulin absorption: different effects on amorphous and soluble insulins.
A rise in ambient temperature stimulates the absorption of soluble, rapid-acting insulin. In the present study, the effect of intensive heat (Finnish sauna) on the absorption of amorphous insulin from a subcutaneous injection site in eight patients with type I diabetes was examined. The rate of absorption was determined by external measurement of the disappearance rate of 125I-labelled intermediate-acting (Semilente) insulin. The sauna (twice for 25 min at 85 degrees C) failed to stimulate insulin absorption significantly or to lower blood glucose levels as compared to a control day at 22 degrees C. Thus, heat has a different effect on the pharmacokinetics of amorphous and soluble insulins.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000378:metabolism*; D049528:Insulin, Long-Acting / Q000008:administration & dosage / Q000378:metabolism*; D061389:Insulin, Regular, Pork; D007700:Kinetics; D008297:Male; D012995:Solubility; D029002:Steam Bath
D001786:Blood Glucose; D007328:Insulin; D049528:Insulin, Long-Acting; D061389:Insulin, Regular, Pork; C000006:insulin, neutral