Uptake of carbon monoxide by C3H mice following X irradiation of lung only or total-body irradiation with 60Co.
Carbon monoxide uptake (Vco) and ventilation rate (VR) of C3H mice were determined at 14 weeks following either X irradiation of lungs only or total-body irradiation with 60Co at different dose rates. Following localized X irradiation of lung at 97 cGy/min there was a reduction in Vco, which was inversely related to radiation dose, with a small reduction below control levels being detected at 7 Gy, the lowest dose tested. An increase in VR could be detected only at doses of 11 Gy, or more. Another group of animals received 11.5 Gy total-body irradiation at either 26.2 or 4.85 cGy/min followed by transplantation with syngeneic bone marrow. Following total-body irradiation, Vco was significantly reduced by about 37% at the higher dose rate and 23% at the lower dose rate. In contrast, a trend toward elevated VR was detected only at the higher dose rate. The results indicate that Vco is a sensitive indicator of radiation-induced lung injury and that under the experimental conditions used Vco is a more sensitive indicator of radiation-induced lung injury in C3H mice than VR.
D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D002248:Carbon Monoxide / Q000378:metabolism*; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008168:Lung / Q000502:physiology / Q000528:radiation effects*; D051379:Mice; D008809:Mice, Inbred C3H; D011832:Radiation Injuries / Q000378:metabolism*; D012119:Respiration; D014916:Whole-Body Irradiation; D014965:X-Rays
D003037:Cobalt Radioisotopes; D002248:Carbon Monoxide