title: Severe local tissue lesions after chemonucleolysis with collagenase.
abstract: The authors report the case of a young female patient submitted to chemonucleolysis at L4-5 with collagenase, in whom severe tissue lesions affecting the cartilaginous end-plate, the vertebral bone, the posterior intervertebral ligament, the epidural fat, and the dura mater were verified at laminectomy, which had become necessary due to functional motor deterioration.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D003012:Microbial Collagenase / Q000008:administration & dosage / Q000009:adverse effects*; D011859:Radiography; D013118:Spinal Cord Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D013122:Spinal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D003012:Microbial Collagenase