[Effect of a glucose-insulin-potassium mixture on the size and clinical course of myocardial infarct].
In order to limit the spread of myocardial infarction, 56 patients with acute myocardial infarction, admitted to hospital within 10 hours after the attack, for two days received continuous intravenous drip infusion of glucose-insulin-potassium mixture (GIP) containing: 300 ml glucose, 50 U common insulin, 60 meqv potassium chloride per 1 1 of the solution, at the rate of 1 ml/kg/hour. A control group of 48 patients were given saline solution at the rate of 20 drops/minute for the same duration of time. In the GIP-treated group, the frequency of cardiac rhythm disorders and clinical signs of heart failure was significantly lower. In spite of a certain improvement in the clinical pattern of the disease, hospital mortality rates did not differ statistically between the treated and control patients. GIP treatment did not reduce the spread of myocardial infarction, as evidenced by electrocardiographic charting and routine assays of serum CPK activity.
D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000188:drug therapy*; D011188:Potassium / Q000008:administration & dosage*; D013997:Time Factors
D007328:Insulin; D005947:Glucose; D011188:Potassium
Vliianie gluikozo-insulino-kalievoĭ smesi na razmery i klinicheskoe techenie infarkta miokarda.