Fine-specificity of the immune response to oxazolones. IV. Furyloxazolone-specific cytolytic T lymphocytes (unlike antibodies) are not heteroclitic.
Antibodies, raised in CBA and C3H mice, to a hapten 2-furyloxazolone (furyl Ox) have a strange (heteroclitic) fine-specificity, having a higher affinity for the chemical analogue 2-styryloxazolone (styryl Ox) than for furyl Ox. Other mouse strains were found to produce 'normal' anti-furyl Ox antibodies, and the heteroclicity was inherited as an Igh allotype-linked trait (Mäkelä, Matoso-Ferreira & Kaartinen 1983). Hapten-specific cytolytic T lymphocytes (CTL) were generated by painting cyclophosphamide-treated mice with chemically reactive haptens, furyl Ox and styryl Ox, and their fine-specificity was investigated. Cytolytic cells generated in this way were 'homoclitic' in all cases, showing a preference for targets coupled with the homologous haptens (the immunogens).
D000818:Animals; D000915:Antibody Affinity; D000918:Antibody Specificity; D003602:Cytotoxicity, Immunologic; D005260:Female; D006241:Haptens / Q000032:analysis / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010080:Oxazoles / Q000276:immunology*; D010081:Oxazolone / Q000031:analogs & derivatives / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006241:Haptens; D010080:Oxazoles; D010081:Oxazolone; C032541:2-furyl-4-ethoxymethylene-5-oxazolone; C040284:2-styryl-4-ethoxymethylene-5-oxazolone