[Manifestation of glucose-6-phosphate dehydrogenase deficiency caused by primaquine in malaria therapy].
This is a report about a 9 year old turkish boy suffering from recurrent episodes of high fever caused by Plasmodium vivax-infection (Malaria tertiana), 12 months after returning from his malarious homeland. After a 3-day course of Chloroquin, we administrated Primaquin to eliminate residual extraerythrocyte forms of Plasmodium vivax. On the 7th day of treatment acute haemolysis developped. This was caused by Glucose-6-Phosphate-Dehydrogenase-Deficiency, which could be demonstrated by a red-cell-enzyme analysis. The investigation of the patient's whole family showed the typical recessive X-linked inheritance of this enzyme-defect. Frequency and clinical manifestations of this defect are discussed.
D002648:Child; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000139:chemically induced* / Q000235:genetics; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D010375:Pedigree; D010966:Plasmodium vivax; D011319:Primaquine / Q000009:adverse effects* / Q000627:therapeutic use
D011319:Primaquine
Manifestation eines Glukose-6-Phosphatdehydrogenase-Mangels durch Primaquin bei Malariatherapie.