title: Mechanism of ribosome frameshifting during translation of the genetic code.
abstract: Some frameshift mutations are strongly suppressed by limitation for particular aminoacyl-tRNA species. Here, we show that ribosome frameshifting at a specific tryptophan codon during Trp-tRNA limitation accounts for suppression of a group of downstream frameshift alleles in the rIIB gene of bacteriophage T4. Genetic and physiological observations strongly suggest that ribosome frameshifting at this position depends on the binding of a noncognate (leucine) tRNA.
mesh_terms: D003062:Codon; D004926:Escherichia coli / Q000235:genetics; D005815:Genetic Code; D010641:Phenotype; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012346:RNA, Transfer, Amino Acyl / Q000235:genetics*; D012270:Ribosomes / Q000502:physiology*; D013489:Suppression, Genetic; D014364:Tryptophan / Q000235:genetics
chemical_list: D003062:Codon; D012333:RNA, Messenger; D012346:RNA, Transfer, Amino Acyl; D014364:Tryptophan