Natural cytotoxicity in rats: radiation-induced changes in the early killing of allogeneic cells.
In some strain combinations among inbred rats intravenously injected 51Cr-labeled lymphocytes are rapidly destroyed in substantial numbers by unsensitized allogeneic hosts. This phenomenon has been referred to as natural cytotoxicity (NC) and is characterized by decreased lymph node radioactivity, increased kidney and urine radioactivity, and to a lesser extent increased liver radioactivity in allogeneic hosts, when compared with the distribution of label in syngeneic recipients of the same cell suspension. A single exposure to 800 rad either 1 or 7 days before the injection of 51Cr-labeled lymphocytes effected a reduction in NC as defined by all the above parameters in a strain combination exhibiting high NC. The same dosage of radiation abolished NC in a strain combination exhibiting intermediate leads to low NC. Because NC was not always completely abolished, the phenomenon was held to be partially radiosensitive. An increased accumulation of 51Cr-labeled lymphocytes was seen in the lymph nodes of both syngeneic and allogeneic irradiated hosts when compared with nonirradiated controls, although the increase was greater in allogeneic than in syngeneic hosts. This increased colonization in the lymph nodes of irradiated hosts seemed unlikely to be due to an increase in the available "space' in the lymph nodes following irradiation.
D000818:Animals; D002465:Cell Movement / Q000528:radiation effects; D002860:Chromium Radioisotopes; D003602:Cytotoxicity, Immunologic / Q000528:radiation effects*; D007113:Immunity, Innate / Q000528:radiation effects; D007668:Kidney / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects; D008198:Lymph Nodes / Q000166:cytology / Q000528:radiation effects; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000528:radiation effects; D014916:Whole-Body Irradiation
D002860:Chromium Radioisotopes