Glutathione depletion enhances the lifetime of oxygen-reactive radicals in mammalian cells.
When the cellular glutathione content is reduced, adding oxygen (130 mumol dm-3) 7 ms after irradiation of hypoxic cells increases the radiosensitivity (factor approximately 1.25), whereas it has much less effect in normal cells.
D000818:Animals; D019328:Buthionine Sulfoximine; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D005978:Glutathione / Q000502:physiology*; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives / Q000494:pharmacology; D010100:Oxygen / Q000502:physiology*; D011836:Radiation Tolerance; D013997:Time Factors
D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005978:Glutathione; D010100:Oxygen