Effects of tissue antigen matching on the healing of fresh cancellous bone allografts in dogs.
The radiographic and histologic healing patterns of fresh cancellous bone allografts were compared with those of fresh cancellous autografts in dogs. Two groups of allografts were studied: 1 group of littermate pairs with minor histocompatibility mismatches, and 1 group of unrelated pairs with major histocompatibility mismatches. Pairs were chosen on the basis of preoperative serologic typing and mixed lymphocyte cultural assay of lymphocyte-defined compatibility. Generally, grafts with minor mismatches and autografts achieved bony union in 6 weeks with grafted bone serving as a scaffold for new bone formation. Grafts with major mismatches were resorbed and replaced by fibrocartilage. Healing of osteotomy sites grafted with mismatched bone occurred by ingrowth of host periosteal and endosteal new bone.
D000818:Animals; D016025:Bone Transplantation; D001842:Bone and Bones / Q000033:anatomy & histology; D004285:Dogs / Q000502:physiology*; D006649:Histocompatibility Antigens / Q000276:immunology*; D006650:Histocompatibility Testing / Q000662:veterinary; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014945:Wound Healing
D006649:Histocompatibility Antigens