Absorption of various drugs through the rabbit's respiratory mucosa in vitro.
The absorption of doxycycline (DOTC), bekanamycin (AKM), cefazolin (CEZ), penicillin G (PC-G), prednisolone, and human IgG through the rabbit's tracheal mucosa was examined using the double-chamber method. The results indicate that the tracheal mucosa can absorb both small molecules and macromolecules. Passing through the intercellular space, DOTC, a small molecule, was absorbed through the tracheal epithelium by diffusion. Human IgG, a macromolecule, was absorbed by the mechanism of an energy-consuming transport process. This study of the absorption of drugs through the respiratory mucosa could open up new areas in the utilization of intrarespiratory administration of drugs and lead to a better understanding of the mechanisms involved in respiratory allergies.
D000042:Absorption; D000818:Animals; D002437:Cefazolin / Q000378:metabolism; D004318:Doxycycline / Q000378:metabolism; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000378:metabolism; D007612:Kanamycin / Q000031:analogs & derivatives / Q000378:metabolism; D009092:Mucous Membrane / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism*; D010400:Penicillin G / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011239:Prednisolone / Q000378:metabolism; D011817:Rabbits; D012137:Respiratory System / Q000378:metabolism*
D007074:Immunoglobulin G; D004364:Pharmaceutical Preparations; C001495:bekanamycin; D007612:Kanamycin; D011239:Prednisolone; D002437:Cefazolin; D004318:Doxycycline; D010400:Penicillin G