title: Preliminary characterization of the mutagenic properties of 'necatorin', a strongly mutagenic compound of the mushroom Lactarius necator.
abstract: The mutagenic activity of 'necatorin', a strongly mutagenic compound isolated from the wild edible mushroom Lactarius necator, was studied with the Ames test, the bacterial intraperitoneal host-mediated assay and the micronucleus test. Whereas the results of the Ames tests were clearly positive, no evidence of mutagenicity was detectable in host-mediated assays or micronucleus tests.
mesh_terms: D000363:Agaricales / Q000032:analysis*; D000818:Animals; D001711:Biotransformation; D002467:Cell Nucleus / Q000187:drug effects; D003374:Coumarins / Q000302:isolation & purification*; D004912:Erythrocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification*; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D003374:Coumarins; D009153:Mutagens; C038744:necatorin