title: Effectiveness of leishmanization in the control of cutaneous leishmaniasis.
abstract: To find out the effectiveness of leishmanization in the control of zoonotic cutaneous leishmaniasis, more than 250 persons were inoculated by the 5th subculture of a strain of L. tropica major kept on laboratory mice. About 47% took with incubation period ranging from less than one month to more than 1 year. The duration of the lesion was from 3 months 1/2 to 13 months 1/2. The two year incidence of the natural infection in this hyperendemic area was 0.8% for "takes", and 10.5% for "non-takes" and 40% for controls. By doing leishmanin skin test two years after inoculation, it is concluded that leishmanization has a protective effect of about 80% in this endemic area.
mesh_terms: D002675:Child, Preschool; D005455:Fluorescent Antibody Technique; D006801:Humans; D007114:Immunization; D007492:Iran; D007896:Leishmaniasis / Q000517:prevention & control*