Multiple strains of Plasmodium falciparum are necessary for the growth inhibition assay.
Sixty-seven serum samples from individuals living in a malaria endemic area and sixty sera from healthy blood donors living in Bangkok (non-malarious area) were tested for growth inhibition activity against 3 strains (SO, SN and G-112) of Plasmodium falciparum. Forty-eight percent of the sera from the endemic area were positive when all 3 strains were tested. Among the positive sera, positive rates of 90.6% were observed for the SO and SN strain combination, 87.5% for the SO and G-112 combination, and 50% for the SN and G-112 combination. It is therefore recommended that multiple parasite strains should be tested in the growth inhibition assay. If facilities are limited, a minimum of two strains should be used, one of which is the SO strain or its equivalent.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D006801:Humans; D007158:Immunologic Techniques; D008288:Malaria / Q000276:immunology*; D010963:Plasmodium falciparum / Q000145:classification / Q000254:growth & development / Q000276:immunology*; D013045:Species Specificity
D000906:Antibodies