Effect of micronutrients, antioxidants and related compounds on the mutagenicity of 3,2'-dimethyl-4-aminobiphenyl, a colon and breast carcinogen.
The possible antimutagenic effects of butylated hydroxytoluene (BHT), ethoxyquin, disulfiram, indole-3-carbinol, indole-3-acetonitrile, sodium selenite and alpha-tocopherol on 3,2'-dimethyl-4-aminobiphenyl-induced mutagenicity were studied using the Ames Salmonella/mammalian microsome assay system with strains TA98 and TA100. All seven compounds were nonmutagenic in both bacterial tester strains. The addition of or 50-250 micrograms of sodium selenite, 5-50 mg of alpha-tocopherol or 50-250 microgram of BHT per plate inhibited DMAB-induced mutagenicity in TA98 and/or TA100. Ethoxyquin, disulfiram and indole-3-carbinol increased DMAB-induced mutagenicity in TA100, whereas these compounds had little or no effect in TA98-3-acetonitrile had very little effect in either strain.
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds / Q000037:antagonists & inhibitors*; D000818:Animals; D000975:Antioxidants / Q000633:toxicity*; D003110:Colonic Neoplasms; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors*; D008325:Mammary Neoplasms, Experimental; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds; D000975:Antioxidants; D009153:Mutagens; C001042:2',3-dimethyl-4-aminobiphenyl; D004159:Diphenylamine