title: [Role of the anticodon in recognition of tRNA by aminoacyl-tRNA-synthetases].
abstract: The nucleic acid-protein interactions are considered for mutual recognition of transfer RNAs and cognate aminoacyl-tRNA synthetases. The validity of the first recognition hypothesis (1964) which postulated the participation of anticodons in this process has been proved both for prokaryote and eukaryote tRNA species. This conclusion stems from numerous data obtained by means of different methodological approaches. These experimental observations concern the majority of tRNAs belonging to the main structural class of tRNAs with a short variable loop. Structural basis of recognition for some tRNAs (with long variable loop) remains obscure.
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D000818:Animals; D000926:Anticodon / Q000235:genetics*; D001483:Base Sequence; D004926:Escherichia coli / Q000235:genetics; D009690:Nucleic Acid Conformation; D012343:RNA, Transfer / Q000235:genetics*; D013045:Species Specificity
chemical_list: D000926:Anticodon; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases
vernacular_title: Rol' antikodona v uznavanii tRNK aminoatsil-tRNK-sintetazami.