[Idiotype-specific inactivation by xenogeneic antisera of T killers but not of T-MIF producers immune to H-2 complex antigens].
Following appropriate absorption rabbit serum to CBA anti-C57BL/6 lymph node cells (rabbit ISS) and rat serum to enriched CBA anti-C57BL/6 T killers (rat ISS) selectively inhibited the activity of K-anti-b T killers but did not affect T killers of other specificities (K-anti-d, d-anti-b). Rabbit ISS did not suppress the capacity of CBA anti-C57BL/6 (K-anti-b) T cells to produce MIF. Under the same conditions, anti-Thy-1.2 serum inactivated killers and K-anti-b MIF-producers. The findings indicate that the killers and MIF-producers immune to the antigens of H-2 complex constitute different subpopulations of T cells, which appear to carry nonidentical sets of idiotypes.
D000818:Animals; D000918:Antibody Specificity; D003602:Cytotoxicity, Immunologic; D005260:Female; D006183:H-2 Antigens / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology*; D007108:Immune Tolerance; D007114:Immunization / Q000379:methods; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits; D014181:Transplantation Immunology
D006183:H-2 Antigens; D007106:Immune Sera; D007130:Immunoglobulin Idiotypes; D008263:Macrophage Migration-Inhibitory Factors
Idiotipospetsificheskaia inaktivatsiia ksenogennymi antisyvorotkami T-killerov, no ne T-MIF-produtsentov, immunnykh k antigenam kompleksa H-2.