[Morphine receptors in rat liver mitochondrial membranes].
In vitro essays carried out on rat liver mitochondria show that morphine enhances fluorescence of membrane-bound 1-anilinonaphtalene-8-sulphonate. These and our previous reports about morphine action on oxidative phosphorylation in rat liver mitochondria demonstrate that the neurotropic drug has also a more general effect on non-nervous cells, masked till now by the more impressive effect on the nervous system. Our results may open a way to explain how injecting opiates continuously and directly in the cerebrospinal fluid or producing endorphins directly at the cerebrospinal level by acupuncture prevent addiction, constipation and other side-effects.
D000817:Anilino Naphthalenesulfonates; D000818:Animals; D005456:Fluorescent Dyes; D007425:Intracellular Membranes / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009020:Morphine / Q000494:pharmacology; D051381:Rats; D011957:Receptors, Opioid / Q000378:metabolism*
D000817:Anilino Naphthalenesulfonates; D005456:Fluorescent Dyes; D011957:Receptors, Opioid; C027132:1-anilino-8-naphthalenesulfonate; D009020:Morphine
Récepteurs de membranes mitochondriales hépatiques de rat pour la morphine.