title: [Plasma retinol, beta-carotene and ascorbic acid levels and functional activity of lymphocytes in patients with large intestine cancer].
abstract: The content of retinol and ascorbic acid in blood plasma and lymphocytes of colonic cancer patients was 2-3 times as reduced as compared to that in donors. The beta-carotene content in the patients' blood plasma did not show any statistical changes. The low content of vitamins A and C in the plasma correlated in the same patients with inhibition of the cell proliferative response to alloantigens in a mixed lymphocyte culture and with a reduction in the lymphocyte response to the T cell mitogen ConA. The proliferative activity of lymphocytes stimulated with the B cell mitogen PWM was lowered in patients insignificantly. The blood plasma retinol was measured by high-pressure liquid chromatography, with the use of C19-retinoid as an internal reference. The beta-carotene content was measured by a combination diffusion laser spectrometer, Mole-77.
mesh_terms: D000230:Adenocarcinoma / Q000097:blood*; D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000097:blood*; D001402:B-Lymphocytes / Q000276:immunology; D002338:Carotenoids / Q000097:blood*; D002430:Cecal Neoplasms / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood; D006801:Humans; D007414:Intestinal Neoplasms / Q000097:blood*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology; D014801:Vitamin A / Q000097:blood*; D019207:beta Carotene
chemical_list: D019207:beta Carotene; D014801:Vitamin A; D002338:Carotenoids; D001205:Ascorbic Acid
vernacular_title: Soderzhanie retinola, beta-karotina, askorbinovoĭ kisloty v plazme krovi i funktsional'naia aktivnost' limfotsitov bol'nykh rakom tolstoĭ kishki.