An application of immunocytology to the analysis of the cell kinetics of upper respiratory and digestive tract squamous carcinoma.
An antinucleoside immunofluorescence technique (ANIF) facilitated evaluation of labeling index (LI) from frozen sections of 36 upper respiratory and digestive tract squamous cancers (URDTS) from a group of 35 patients. There were 35 URDTS of the larynx, oral cavity, or pharynx and the LIs of this population ranged from 0-39.4%, (mean, 14.7%); 6% of URDTS (2 of 36) were not assessable by ANIF. The administration of nontherapeutic radioactive materials, the establishment of cell cultures, and perturbations in cell growth implicit in the removal of tumor from host prior to assessment are unnecessary in the application of this technique.
D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004067:Digestive System Neoplasms / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007700:Kinetics; D012142:Respiratory Tract Neoplasms / Q000378:metabolism*
D004273:DNA, Neoplasm