Anti-inflammatory factors in sponge-induced exudate in the rat.
Sterile polyester sponge-induced exudates in the rat have been investigated for high molecular weight substances with anti-inflammatory activity against carrageenan-induced oedema in the rat. The only substances found with this activity were dialysable molecules. Crude but sterile protein fractions isolated from exudate stabilized guinea-pig macrophages at low concentrations. The proteins present in exudates appeared to be identical to normal rat plasma proteins. It is concluded that anti-inflammatory activity associated with high molecular substances in exudate may have been due to bacterial contamination.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D000893:Anti-Inflammatory Agents; D004487:Edema / Q000276:immunology; D005122:Exudates and Transudates / Q000032:analysis*; D006168:Guinea Pigs; D007122:Immunoelectrophoresis; D066298:In Vitro Techniques; D008264:Macrophages / Q000378:metabolism; D010447:Peptide Hydrolases / Q000032:analysis; D011817:Rabbits / Q000276:immunology; D051381:Rats
D000893:Anti-Inflammatory Agents; D000135:Acid Phosphatase; D010447:Peptide Hydrolases