title: Escherichia coli xth mutants are hypersensitive to hydrogen peroxide.
abstract: Escherichia coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-induced lethality and the in vivo role of exonuclease III.
mesh_terms: D002374:Catalase / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D005090:Exodeoxyribonucleases / Q000502:physiology*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D009154:Mutation; D010641:Phenotype
chemical_list: D006861:Hydrogen Peroxide; D002374:Catalase; D005090:Exodeoxyribonucleases; C020133:exodeoxyribonuclease III