Histocompatibility antigens HLA-A, -B, -DR in Greek patients with Kaposi's sarcoma.
Thirty-two Greek patients with histologically documented Kaposi's sarcoma, aged 46 to 82 years, were typed for HLA-A, B and DR antigens. None of them was homosexual and they had not been subjected to any immunosuppressive therapy. The study revealed a significant increase of HLA-DR5 (53.1% vs. 21.4%, R.R. 4.1) and a decreased frequency of HLA-DR1 (3.3% vs. 16.6%, R.R. 0.16). An increased frequency of HLA-B18 was also noted (43.7% vs. 20.7% R.R. 2.96). These results indicate that the same positive association with HLA-DR5 antigen is observed in Greek patients as in other patients of Mediterranean origin and support the view that HLA linked factor(s) may have a role in the development of the disease.
D000368:Aged; D005260:Female; D006115:Greece; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D059950:HLA-B52 Antigen; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II; D006801:Humans; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000276:immunology*
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D059950:HLA-B52 Antigen; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II