Ecotropic and dualtropic mink cell focus-inducing murine leukemia viruses can induce a wide spectrum of H-2 controlled lymphoma types.
Neonatal infection of C57BL and BALB/c mice by cloned ecotropic and dualtropic mink cell focus-inducing (MCF) murine leukemia viruses (MuLV) induces a wide spectrum of different lymphomas of T, B, and non-T/non-B cell types. Oncogenic dualtropic MCF viruses and poorly oncogenic ecotropic MuLV act synergistically in lymphomagenesis. Within one mouse strain virus-induced T-cell lymphomas arise earlier than B-cell lymphomas after neonatal inoculation of a single-cloned MuLV. The host genetic constitution, notably the H-2 complex has a marked influence on lymphoma type. This H-2 influence can be explained by an H-2-linked difference in penetration of the thymus early in life by oncogenic thymotropic MuLV, which in turn is correlated with, but not necessarily due to the magnitude of the anti-MuLV antibody response.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000382:microbiology; D002454:Cell Differentiation; D006183:H-2 Antigens; D008223:Lymphoma / Q000382:microbiology*; D051379:Mice; D008815:Mice, Inbred Strains; D008907:Mink / Q000382:microbiology; D012190:Retroviridae / Q000502:physiology*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000382:microbiology; D014779:Virus Replication
D000954:Antigens, Surface; D006183:H-2 Antigens