title: Effects of lincomycin and tetracycline on production and properties of enterotoxins of enterotoxigenic Escherichia coli.
abstract: Enterotoxigenic Escherichia coli grown in the presence of lincomycin and tetracycline produced an increased amount of heat-labile enterotoxin (LT). These antibiotics increased the production of not only extracellular LT but also intracellular LT. On the other hand, lincomycin did not stimulate the production of heat-stable enterotoxin by enterotoxigenic E. coli. The extracellular LTs produced in the presence of lincomycin and tetracycline were purified and analyzed by sodium dodecyl sulfate-polyacrylamide gel disc electrophoresis. Results showed that the A subunits of the purified LTs were not nicked, unlike that of extracellular LT produced in the absence of the antibiotics.
mesh_terms: D000900:Anti-Bacterial Agents / Q000633:toxicity; D004768:Enterotoxins / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects* / Q000502:physiology; D008034:Lincomycin / Q000633:toxicity*; D013045:Species Specificity; D013752:Tetracycline / Q000633:toxicity*; D014357:Trypsin
chemical_list: D000900:Anti-Bacterial Agents; D004768:Enterotoxins; D008034:Lincomycin; D014357:Trypsin; D013752:Tetracycline