title: Mutagenicity of constituents of pulp and paper mill effluent in growing cells of Saccharomyces cerevisiae.
abstract: 42 compounds identified in pulp mill effluent were screened for genetic activity in growing yeast cells using strains D7 and XV185-14C without S9. In addition to 3 of these compounds that had been shown previously to be mutagenic in Salmonella. 5 more were mutagenic in strain XV185-14C. All 8 induced 2-5-fold increases in reversion frequencies over background at the trp5 locus--5 of these induced 1.5-3-fold increases at the hom3 locus and 1 induced a doubling at his1. None of the compounds induced absolute increases of gene convertants per plate in strain D7, although 3 showed increased convertant frequencies as survival decreased.
mesh_terms: D005785:Gene Conversion / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens; D010209:Paper; D012441:Saccharomyces cerevisiae / Q000187:drug effects*; D014934:Wood
chemical_list: D009153:Mutagens