Clear cell carcinoma of the ovary with colony-stimulating-factor production. Occurrence of marked granulocytosis in a patient and nude mice.
A case of clear cell carcinoma of the ovary with colony-stimulating-factor (CSF) production is presented. Granulocytosis (54,200/mm3) of unknown cause was observed in a patient at the terminal stage of the clinical course. This tumor was successfully heterotransplanted into athymic nude mice, and transplantable tumor line was designated as OCL-1. OCL-1 tumor reproduced granulocytosis up to 640,000/mm3 in nude mice, and CSF production was demonstrated by colony-forming assay using tumor extract and mouse bone marrow cells in vitro. This is the first report that describes the case of CSF-producing clear cell carcinoma of the ovary and its heterotransplantation in nude mice.
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002118:Calcium / Q000097:blood; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D005260:Female; D006098:Granulocytes; D006801:Humans; D007958:Leukocyte Count; D007964:Leukocytosis / Q000209:etiology*; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D014183:Transplantation, Heterologous
D003115:Colony-Stimulating Factors; D002118:Calcium