Antibody response after influenza immunization in renal transplant patients receiving cyclosporin A or azathioprine.
Nineteen renal transplant recipients receiving cyclosporin A and prednisone, eight kidney recipients receiving azathioprine and prednisone, and 12 healthy volunteers were immunized with 0.5 ml of trivalent influenza vaccine containing A/Bangkok/1/79 (H(3)N(2)), A/Brazil/11/78 (H(1)N(1)), and B/Singapore/222/79. Nine patients (47%) in the cyclosporin A group and five (63%) in the azathioprine group showed fourfold rises in titer to at least one virus strain compared with 12 (100%) in the control group.
D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation / Q000187:drug effects; D001379:Azathioprine / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D006801:Humans; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000276:immunology*; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000628:therapy; D016030:Kidney Transplantation
D000914:Antibodies, Viral; D003524:Cyclosporins; D007252:Influenza Vaccines; D001379:Azathioprine