Therapeutic approaches to reducing insulin resistance in patients with noninsulin-dependent diabetes mellitus.
Patients with noninsulin-dependent diabetes mellitus (NIDDM) are characterized by a loss of the normal ability of insulin to stimulate glucose uptake. The effects of diet, exercise, sulfonylurea compounds, and exogenous insulin on in vivo insulin-stimulated glucose uptake have been reviewed in this presentation. Although there is still a great deal to learn about the manner in which these various forms of treatment affect in vivo insulin action, the available information provides a rational framework for therapeutic attempts to enhance insulin sensitivity in patients with NIDDM.
D001835:Body Weight; D003920:Diabetes Mellitus / Q000628:therapy*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007333:Insulin Resistance; D005082:Physical Exertion; D013453:Sulfonylurea Compounds / Q000627:therapeutic use
D004040:Dietary Carbohydrates; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; D005947:Glucose