[The significance of sex determined antigens for kidney transplantation prognosis--an analysis of 500 transplantations at a center].
In a retrospective analysis of survival after 587 kidney transplants from dead donors performed in one centre, the influence of incompatibilities in the HLA-A-B system and the influence of the sex of the donor were analysed. The survival curves for 0, 1, 2, 3 and 4 incompatible antigens of the A and B loci showed no significant differences from the 1st to the 4th years after transplantation. The best survival rate was found among 212 men with kidneys from male donors, despite other disadvantageous factors in this group, whereas 155 women with kidneys from male donors (with a histoincompatibility of the H-Y antigen) had statistically significant low survival rates between 10.1 and 21% (p less than 0.001 - less than 0.003). The survival rates of kidneys from female donors showed no significant differences between men and women (p less than 0.05). The findings indicate that the incompatibility of the histoincompatibility antigen Y can be important for the results of clinical kidney transplantation.
D000328:Adult; D002648:Child; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011379:Prognosis; D012737:Sex Factors; D014181:Transplantation Immunology
D006649:Histocompatibility Antigens
Zur Bedeutung geschlechtsdeterminierter Antigene für die Nierentransplantatprognose--Eine Analyse von 500 Transplantationen eines Zentrums.