Prenatal diagnosis of cystic fibrosis by methylumbelliferylguanidinobenzoate protease titration in amniotic fluid.
Amniotic fluids were obtained from 19 mothers who had previously given birth to a child with cystic fibrosis. Measurement of methylumbelliferylguanidinobenzoate (MUGB) reactive proteases suggested that all 19 would have unaffected babies. Amongst the first 10 cases to come to term there were 5 infants with cystic fibrosis. It is concluded that MUGB protease titration is not suitable for the early prenatal diagnosis of cystic fibrosis.
D000653:Amniotic Fluid / Q000032:analysis*; D003550:Cystic Fibrosis / Q000175:diagnosis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D006923:Hymecromone / Q000031:analogs & derivatives; D010447:Peptide Hydrolases / Q000032:analysis*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014468:Umbelliferones
C017532:4-methylumbelliferylguanidinobenzoate; D014468:Umbelliferones; D006923:Hymecromone; D010447:Peptide Hydrolases