Bicyclic lactam inhibitors of angiotensin converting enzyme.
Syntheses of the potent angiotensin converting enzyme inhibitor 1-(carboxymethyl)-3-(mercaptomethyl)-2,3,4,5-tetrahydro-1H-1- benzazep in -2-one (4a) and the corresponding eight-membered ring analogue (4b) are described. The influence of ring size on the inhibitory potencies of these substances is discussed.
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D001392:Azocines / Q000138:chemical synthesis* / Q000494:pharmacology; D001552:Benzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D002216:Captopril / Q000031:analogs & derivatives*; D008168:Lung / Q000201:enzymology; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D011817:Rabbits
D000806:Angiotensin-Converting Enzyme Inhibitors; D001392:Azocines; D001552:Benzazepines; C041499:3-(mercaptomethyl-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid), dicyclohexylamine salt; C041800:3-(mercaptomethyl)-3,4,5,6-tetrahydro-2-oxo-1H-1-benzazocine-1-acetic acid; D011392:Proline; D002216:Captopril