title: Nonsense mutations in the can1 locus of Saccharomyces cerevisiae.
abstract: Yeast mutants resistant to L-canavanine were selected. All were recessive and fell into the can1 complementation group. Nonsense mutations were identified among them by using a set of different suppressors. Frequencies of UAA, UAG, and presumed UGA mutations were 14.8, 0.8, and 0.4%, respectively. A high incidence of nonsense mutations having discriminatory suppression patterns was characteristic of the locus.
mesh_terms: D002172:Canavanine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005796:Genes; D005816:Genetic Complementation Test; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*; D013489:Suppression, Genetic
chemical_list: D002172:Canavanine