[Interaction with DNA of semisynthetic carminomycin and rubomycin derivatives].
The apparent binding constants and the effect of semisynthetic derivatives of carminomycin and rubomycin (anthracycline antibiotics) on DNA fusion were studied. The following semisynthetic derivatives were used. 13-dihydrocarminomycin, 14-hydroxycarminomycin, 13-(4-methylpiperazinyl) imine carminomycin, 13-benzoylhydrazone carminomycin (carminazone), 13-tret-butoxycarbonyl hydrazone rubomycin, 13-(4-methylpiperazinyl) imine rubomycin, 14-(1-hydroxyl-2,2,6,6-tetramethylpiperidyl-4)-acetoxyrubomycin (spin-labeled rubomycin). The above derivatives slightly differed from the initial antibiotics by their affinity to DNA. The binding constants of methylpiperazinyl imines was 2-3 times higher than those of the respective antibiotics.
D000327:Adsorption; D002360:Carubicin / Q000031:analogs & derivatives / Q000378:metabolism*; D004269:DNA, Bacterial / Q000378:metabolism*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000378:metabolism; D004347:Drug Interactions; D004926:Escherichia coli; D005609:Free Radicals; D066298:In Vitro Techniques; D013696:Temperature
D004269:DNA, Bacterial; D005609:Free Radicals; D002360:Carubicin; D003630:Daunorubicin
Vzaimodeĭstvie s DNK polusinteticheskikh proizvodnykh karminomitsina i rubomitsina.