Induction of anti-nuclear antibodies by mercuric chloride in mice.
Mercuric chloride (HgCl2) was administered parenterally to outbred Swiss ICR mice of both sexes and to inbred A/J male mice. In repeated experiments both male and female ICR mice developed anti-nuclear antibodies (ANA) giving a distinctive nucleolar fluorescence pattern in response to HgCl2 treatment. Within 1 week after the start of treatment, many of the mice had serum ANA of the IgG class directed against nucleolar antigen(s). Maximum ANA induction was reached by week 4. Inbred A/J male mice were resistant to the induction of ANA by HgCl2.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis*; D002466:Cell Nucleolus / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D008297:Male; D008627:Mercuric Chloride / Q000494:pharmacology*; D051379:Mice; D008805:Mice, Inbred A; D013268:Stimulation, Chemical; D013997:Time Factors
D000974:Antibodies, Antinuclear; D008627:Mercuric Chloride