title: Zinc supplementation and its effect on taste acuity in children with chronic renal failure.
abstract: Diminished taste acuity (hypogeusia) and zinc deficiency have been reported in children on maintenance haemodialysis and with varying degrees of chronic renal failure. We have studied the effect of 6 weeks' zinc supplementation in 20 children with chronic renal impairment using a double-blind crossover trial. Although we achieved significant increases in serum zinc levels no significant improvement in taste acuity could be demonstrated. These studies provide no support for the belief that routine zine supplements are necessary in children with chronic renal failure.
mesh_terms: D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D003300:Copper / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D013651:Taste Disorders / Q000188:drug therapy* / Q000209:etiology; D013652:Taste Threshold; D015032:Zinc / Q000097:blood / Q000627:therapeutic use*
chemical_list: D003300:Copper; D015032:Zinc