Age-dependent depressor effect of L-dopa in dogs with inhibition of extracerebral dopa decarboxylase.
The results of this study demonstrate that a carbidopa-L-dopa combination has a greater depressor effect in puppies than in adult dogs. These effects are believed to be due to the action of a metabolite of L-dopa within the CNS. These data should alert clinicians to the possibility that CNS cardiovascular control centers, which utilize catecholamines as neuromediators, may be more responsive to pharmacological stimulation in the young than in the adult.
D000375:Aging; D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000201:enzymology*; D002230:Carbidopa / Q000008:administration & dosage* / Q000494:pharmacology; D004285:Dogs; D004359:Drug Therapy, Combination; D006339:Heart Rate / Q000187:drug effects; D007980:Levodopa / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects; D013997:Time Factors
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D007980:Levodopa; D012083:Renin; D002230:Carbidopa