[Immediate hypersensitivity to lacrimal gland proteins in sicca syndromes].
A biological study was conducted on tears from 20 subjects with a clinical sicca syndrome. Electrophoresis of lacrymal proteins, determination of lacrymal and salivary immunoglobulins G, and a human basophil degranulation test (HBDT) with a lacrymal gland extract as antigen were performed in each patient. Three different groups could be distinguished: a group with normal electrophoresis and normal HBDT corresponding to hyposecretion; a second group with abnormal electrophoresis and negative HBDT corresponding to an inflammatory state of the lacrymal gland; and a third group with abnormal electrophoresis and positive HBDT corresponding to a deficit in synthesis function of the lacrymal gland. These findings demonstrate that HBDT with lacrymal gland extract as antigen is a reliable means of diagnosis of the sicca syndrome.
D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology; D001491:Basophils / Q000276:immunology; D004586:Electrophoresis; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007158:Immunologic Techniques; D007765:Lacrimal Apparatus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000276:immunology*; D013666:Tears / Q000276:immunology*; D014985:Xerophthalmia / Q000175:diagnosis / Q000276:immunology*
D000941:Antigens; D011506:Proteins
Hypersensibilité immédiate aux protéines de la glande lacrymale au cours des syndromes secs.