Effect of postmortem ischemia on the function of adult rat islets following pancreatic transplantation.
Pancreata from adult rats were subjected to in situ postmortem ischemia at ambient temperature for between 90 and 360 minutes before syngeneic transplantation into diabetic recipients. Islet function, determined by recipient blood glucose and intravenous glucose tolerance tests, was not significantly different from that observed in nonischemic controls after up to 300 minutes of such an insult. Transplantation led to death of pancreata subjected to 360 minutes of ischemia in four or five recipients. Clinical and experimental implications are discussed.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005951:Glucose Tolerance Test; D007511:Ischemia / Q000503:physiopathology*; D007515:Islets of Langerhans / Q000502:physiology*; D008297:Male; D009926:Organ Preservation; D010179:Pancreas / Q000098:blood supply; D016035:Pancreas Transplantation; D051381:Rats; D013696:Temperature
D001786:Blood Glucose