Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation.
Insulin directly inhibits protein phosphorylation in isolated rat liver nuclear envelopes. In the present studies, an antiserum to insulin receptor as well as the plant lectins concanavalin A and phytohemagglutinin mimicked insulin action in isolated nuclear envelopes. These studies suggest that insulin and agents that mimic it may directly regulate nuclear functions.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007106:Immune Sera; D007328:Insulin / Q000494:pharmacology*; D037102:Lectins / Q000494:pharmacology*; D009685:Nuclear Envelope / Q000187:drug effects* / Q000378:metabolism; D010766:Phosphorylation; D010835:Phytohemagglutinins / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000276:immunology*
D007106:Immune Sera; D007328:Insulin; D037102:Lectins; D010835:Phytohemagglutinins; D003208:Concanavalin A; D011972:Receptor, Insulin