Brief prophylaxis with doxycycline for the prevention of traveler's diarrhea.
A prospective, randomized double-blind trial of doxycycline prophylaxis for traveler's diarrhea was conducted on 145 volunteers during a 2.5-day visit to Mexico. Traveler's diarrhea occurred in 15 (21%) of the placebo group and in 3 (4%) of the doxycycline group (p = 0.002). There was no rebound increase in the incidence of acute diarrhea after departure from the high risk area in the doxycycline-treated group. A variety of bacterial pathogens were isolated from individuals symptomatic with traveler's diarrhea. Nausea alone (8%) or nausea with vomiting (4%) occurred in the doxycycline-treated group only and were the only side effects observed (p = 0.003). We conclude that doxycycline is safe and efficacious for the prophylaxis of traveler's diarrhea for short-term exposure in a high risk area.
D000293:Adolescent; D000328:Adult; D003967:Diarrhea / Q000517:prevention & control*; D004311:Double-Blind Method; D004318:Doxycycline / Q000009:adverse effects / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013997:Time Factors; D014195:Travel; D014839:Vomiting / Q000139:chemically induced
D004318:Doxycycline