Phenobarbital compared with carbamazepine in prevention of recurrent febrile convulsions. A double-blind study.
In a double-blind trial, children who had recurrent and/or complex febrile convulsions were treated with either phenobarbital sodium or carbamazepine. Forty children were suitable for analysis; 19 were receiving carbamazepine, and 21 were receiving phenobarbital. Of the carbamazepine-treated patients, nine (47%) had recurrent convulsions despite therapeutic levels of the drug, while only two (10%) of the phenobarbital-treated patients suffered further seizures. These results confirm previous findings suggesting that carbamazepine is not as effective in the prophylactic treatment of febrile convulsions as phenobarbital.
D002220:Carbamazepine / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D012008:Recurrence; D003294:Seizures, Febrile / Q000235:genetics / Q000517:prevention & control*
D002220:Carbamazepine; D010634:Phenobarbital