beta-Pyridylcarbinol (Ronicol) releases a prostacyclin-like substance into arterial blood of patients with arteriosclerosis obliterans.
Beta-pyridylcarbinol (Ronicol) when injected (1,2-1,4 mg/kg i.v.) into four patients with arteriosclerosis obliterans caused a release of an unstable disaggregatory substance into arterial blood of those patients. This release was not observed in other two patients who had been pretreated with aspirin (1,8 g p.o.daily). It is postulated that some of pharmacological properties of nicotinic acid derivatives are mediated through the release of endogenous PGI2-like substance.
D001162:Arteriosclerosis Obliterans / Q000097:blood*; D011464:Epoprostenol / Q000097:blood*; D006801:Humans; D008054:Lipid Peroxides / Q000633:toxicity; D009540:Nicotinyl Alcohol / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000097:blood*; D011725:Pyridines / Q000494:pharmacology*
D008054:Lipid Peroxides; D011453:Prostaglandins; D011725:Pyridines; D009540:Nicotinyl Alcohol; D011464:Epoprostenol