Tumor induction in BALB/c female mice after fission neutron or gamma irradiation.
This study was designed to examine the dose-response relationships for tumor induction after neutron irradiation in female BALB/c mice, with emphasis on the response in the dose range 0 to 50 rad. Tumors induced after radiation exposure included ovarian tumors, lung adenocarcinomas, and mammary adenocarcinomas. For comparison the dose responses for induction of these tumors after 137Cs gamma irradiation were also examined. As previously described for the female RFM mouse, the data for ovarian tumor induction after neutron and gamma irradiation were consistent with a threshold model. For lung and mammary tumors the dose-response curve after neutron irradiation appeared to "bend over" in the dose range 10 to 20 rad. The factors responsible for this bend-over and their relative contributions to the overall form of the dose-response relationship are not presently known. However, these data strongly indicate that extrapolation from data above 50 rad could result in a significant underestimate of risks. Further, it is clear that current models of neutron carcinogenesis are inadequate, since such a bend-over is not predicted at these low dose levels.
D000230:Adenocarcinoma / Q000209:etiology; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons / Q000009:adverse effects*; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000209:etiology; D008325:Mammary Neoplasms, Experimental / Q000209:etiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009502:Neutrons / Q000009:adverse effects*; D010051:Ovarian Neoplasms / Q000209:etiology; D011839:Radiation, Ionizing / Q000009:adverse effects*; D012062:Relative Biological Effectiveness; D014916:Whole-Body Irradiation