Improved synthesis and low-temperature autoradiographic evaluation of 18F-n-fluoropropane as a myelin tracer for positron emission tomography.
An improved synthesis of the lipophile 18F-fluoropropane, yielding 30-45 mCi 18F-labelled radiopharmaceutical, is described. The radiochemical yield was 55%-66% determined at the end of a 1-h synthesis. Radiochemical and chemical purity of 18F-fluoropropane was 99% as determined by gas chromatography. Low-temperature autoradiography was used to investigate the lipophile 18F-n-fluoropropane as a myelin tracer for use with positron emission tomography. The white to grey matter ratio based on autoradiograms 12 min after administration of the radiotracer was 2:1, the highest reported to date.
D000818:Animals; D001345:Autoradiography / Q000379:methods; D003080:Cold Temperature; D005260:Female; D005461:Fluorine; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007553:Isotope Labeling; D009186:Myelin Sheath / Q000000981:diagnostic imaging*; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D014055:Tomography, Emission-Computed / Q000379:methods*
D006845:Hydrocarbons, Fluorinated; D011868:Radioisotopes; D005461:Fluorine; C044703:1-fluoropropane