T-independent macrophage changes in murine malaria.
A study to investigate the participation of T cells in macrophage-mediated responses during malaria was performed in nude (nu/nu) and littermate (nu/+) mice infected with Plasmodium berghei (PB). We found that in both groups of mice spleen cells suppressed the mitogenic response to LPS. Both nu/+ and nu/nu infected mice also showed liver macrophage activation, reflected by increased plasminogen activator release. These findings suggest that at least some of the macrophage changes during malaria infection are T-independent.
D000818:Animals; D002452:Cell Count; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000166:cytology; D008213:Lymphocyte Activation; D008262:Macrophage Activation; D008264:Macrophages / Q000201:enzymology / Q000276:immunology*; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D009929:Organ Size; D010960:Plasminogen Activators / Q000032:analysis; D010962:Plasmodium berghei; D013601:T-Lymphocytes / Q000276:immunology*
D008070:Lipopolysaccharides; D010960:Plasminogen Activators