Stimulation of intestinal chromatin template activity by dietary carbohydrates in adult rats.
Oral administration of a 70% solution of sucrose to starved adult rats resulted 1 h after feeding in a 3.5-fold stimulation of intestinal chromatin template activity assayed in vitro using E. coli RNA polymerase. A similar stimulatory effect was observed with fructose, whereas glucose exhibited a weaker effect, indicating that the nature of the ingested carbohydrate may have a direct effect on the extent of intestinal chromatin template activation.
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D005632:Fructose / Q000494:pharmacology; D007583:Jejunum / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000494:pharmacology; D013698:Templates, Genetic; D014158:Transcription, Genetic / Q000187:drug effects*
D002843:Chromatin; D004040:Dietary Carbohydrates; D005632:Fructose; D013395:Sucrose; D012321:DNA-Directed RNA Polymerases