[Effect of the photo-induced synthesis of serotonin on the photoreactivation of Saccharomyces cerevisiae yeasts].
The photoreactivation of yeast (Saccharomyces cerevisiae) cells irradiated by far-UV-light has been studied. It has been shown that the near-UV-induced (334, 365 nm) synthesis of serotonin in yeast is an underlying cause of its photoreactivation action spectrum change. The effect of serotonin is due to its binding to far-UV-irradiated DNA (pyrimidine dimers) making them unavailable to the photoreactivating enzyme. The data obtained support the idea that serotonin affects the repair enzymes which are engaged in an elimination of lethal photoproducts from DNA.
D004271:DNA, Fungal / Q000378:metabolism / Q000528:radiation effects; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000528:radiation effects*; D012701:Serotonin / Q000096:biosynthesis* / Q000528:radiation effects; D014466:Ultraviolet Rays
D004271:DNA, Fungal; D012701:Serotonin
O vliianii fotoindutsirovannogo sinteza serotonina na fotoreaktivatsiiu drozhzheĭ Saccharomyces cerevisiae.