A controlled clinical trial of iohexol and diatrizoate in aortofemoral angiography.
Iohexol is a recently synthesized non-ionic low-osmolar contrast medium. It has been compared to the conventional ionic hyperosmolar contrast medium diatrizoate (Urografin 60%) in a randomized double-blind crossover study of aortofemoral angiographies of 50 consecutive patients. The intraarterial blood pressures, the pulse rate and ECG were recorded continuously and the reactions of pain and warmth were evaluated. Iohexol caused significantly less haemodynamic changes than Urografin and also the pain reactions were significantly reduced. The quality of the angiograms was equal.
D000328:Adult; D000368:Aged; D001027:Aortography; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006801:Humans; D007463:Iodobenzoates / Q000009:adverse effects*; D007472:Iohexol; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011897:Random Allocation; D014283:Triiodobenzoic Acids / Q000009:adverse effects*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D007472:Iohexol