The effect of culture conditions and toxicity on the Ames Salmonella/microsome agar incorporation mutagenicity assay.
Various methods were used to reconstruct an environment similar to a chemically bactericidal or bacteriostatic effect in the Ames mutagenicity assay in order to determine whether a false-positive result could occur. Neither population reduction, sonication, nor increased histidine produced an increase of spurious revertant colonies.
D000818:Animals; D001711:Biotransformation; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism / Q000633:toxicity*; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
D009153:Mutagens