Does glucose 6-phosphatase regulate metabolic transformation in developing skeletal muscle?
Glycogen content and the activities of phosphorylase, phosphohexose isomerase, aldolase, glucose 6-phosphatase, succinate dehydrogenase, and alanine and aspartate amino-transferases have been biochemically determined in three gastrocnemii muscles of chick up to 9 weeks of postembryonic growth. Decline in glycogen, phosphorylase, phosphohexose isomerase and aldolase with a concomitant increase in succinate dehydrogenase reveals a switchover from glycolytic to oxidative metabolism in muscle. Activities of aminotransferases indicate the utilization of transamination products of alanine and aspartate in oxidative pathway. Transiently increased glucose 6-phosphatase seems to restrict glycogenolytic and glycolytic metabolism and thereby pave way for the acceleration of oxidative metabolism in developing muscle.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001711:Biotransformation; D002645:Chickens; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism* / Q000502:physiology; D006003:Glycogen / Q000378:metabolism; D024510:Muscle Development; D009132:Muscles / Q000378:metabolism*; D006005:Phosphorylases / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
D006003:Glycogen; D013385:Succinate Dehydrogenase; D006005:Phosphorylases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005952:Glucose-6-Phosphatase; D005634:Fructose-Bisphosphate Aldolase