A slide test for detecting neutrophil-associated complement components.
Complement components deposited on neutrophils were detected by a new test that uses staphylococcal protein A and antisera against complement. Serum from three of 51 patients thought to have immune neutropenia deposited complement but not IgG on their own and normal neutrophils. Some cases of immune neutropenia may be caused primarily by complement-mediated neutrophil destruction.
D000328:Adult; D000906:Antibodies / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007163:Immunosorbent Techniques; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000032:analysis*; D013205:Staphylococcal Protein A / Q000276:immunology
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013205:Staphylococcal Protein A; D003165:Complement System Proteins