Dual effect of transplantation immunity on lymphocyte and granulocyte progenitors.
Bone marrow, regional lymph node, and spleen myelo- and lymphopoiesis in vitro were studied in mice subjected to skin grafting across the H-2 barrier. It was demonstrated that during the early days posttransplantation there was an enhancement of myeloid and B and T lymphoid colony formation in agar, whereas at approximately the time of graft rejection a strong inhibition of colony growth was observed. These phenomena were regularly observed using bone marrow and lymph node but were not as apparent with spleen cells. Likewise, colony-stimulating factor production by spleen and lymph node cells was increased initially but later when rejection occurred reached levels lower than those of syngeneic control animals, although PGE2 production was increased at the time of rejection.
D000818:Animals; D002455:Cell Division; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D015232:Dinoprostone; D006098:Granulocytes / Q000166:cytology* / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011458:Prostaglandins E / Q000096:biosynthesis; D016038:Skin Transplantation; D014181:Transplantation Immunology
D003115:Colony-Stimulating Factors; D011458:Prostaglandins E; D015232:Dinoprostone