Augmentation of the proliferative response of thymocytes to phytohemagglutinin by the muramyl dipeptide1.
A synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine or muramyl dipeptide (MDP) and adjuvant-active analogs, but not lipopolysaccharide (LPS), exhibited the augmenting effect on the proliferative response of thymocytes to phytohemagglutinin (PHA). MDP also had a comitogenic effect on PHA-stimulated T lymphocytes. It was shown that the thymocyte-stimulating effect of MDP is not through the production of the monikines by MDP-stimulated macrophages and that MDP has a direct action on lymphocytes.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives / Q000276:immunology*; D000276:Adjuvants, Immunologic; D000818:Animals; D006168:Guinea Pigs; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D010835:Phytohemagglutinins / Q000276:immunology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins; D000119:Acetylmuramyl-Alanyl-Isoglutamine