Role of renal prostaglandin in renin release during renal nerve stimulation in anesthetized dogs.
The relationship of prostaglandin (PG) release to changes in renin release and renal blood flow (RBF) to renal nerve stimulation (RNS) was investigated in pentobarbital anesthetized dogs. Experimental values were obtained before and during RNS (3 or 5 Hz, 10 to 20 V, 1 msec, for 10 min) in the absence and/or presence of indomethacin (5 mg/kg, i.v.), respectively. Plasma renin activity and plasma PGE2 concentration were measured by radioimmunoassay. RNS increased PGE2 secretion rate and renin secretion rate. RBF was initially reduced by RNS, then partial recovery of RBF occurred despite the continuous stimulation. In the presence of indomethacin, the recovery response of RBF and the increase in PGE2 secretion rate during RNS were not observed. Indomethacin also suppressed the increase in renin secretion rate. These results suggest that the renin and RBF responses to RNS are modulated by concomitantly released PG.
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015232:Dinoprostone; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000201:enzymology / Q000294:innervation / Q000502:physiology*; D008297:Male; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000378:metabolism*
D011453:Prostaglandins; D011458:Prostaglandins E; D012083:Renin; D015232:Dinoprostone; D007213:Indomethacin