Effect of cyclosporin A on the induction and activation of B memory cells by thymus-independent antigens in mice.
The effect of cyclosporin A on the induction and activation of B memory cells by thymus-independent (TI) antigens was investigated. Studies were carried out in C57BL/6 mice, a strain in which TI.1 trinitrophenyl-lipopolysaccharide (TNP-LPS) and TI.2 dinitrophenyl-(DNP)-Ficoll antigens can elicit a secondary response. Evidence is presented that cyclosporin A does not adversely affect the primary or secondary response to TNP-LPS. In contrast, this fungal metabolite prevents the triggering of virgin B lymphocytes and TNP-LPS-induced memory cells by DNP-Ficoll. Cyclosporin A does not interfere with the generation of hapten-specific B memory cells by TNP-LPS or DNP-Ficoll. These findings are discussed in terms of B cell lineages leading to antibody-forming cell precursors and memory cells.
D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D003524:Cyclosporins / Q000494:pharmacology*; D005362:Ficoll / Q000031:analogs & derivatives / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007156:Immunologic Memory / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009596:Nitrophenols; D014301:Trinitrobenzenes / Q000276:immunology
D000955:Antigens, T-Independent; D003524:Cyclosporins; C031007:DNP-Ficoll; D009596:Nitrophenols; C020529:TNP-ficoll; D014301:Trinitrobenzenes; D005362:Ficoll