[Evaluation of the functions of human neutrophils by their reaction to a bacterial stimulus].
The principle of functional loading, i.e. stimulation of the neutrophiles with enterobacterial inactivated vaccine in vitro or with bacterial polysaccharides in vivo followed by the NBT-test is recommended for adequate estimation of the neutrophile link in the system of the host defense from infections. 97 practically healthy persons were examined in Novosibirsk and Norilsk and it was shown that in the regions of the Far North there were differences among the population with respect to the initial functional activity of the neutrophiles and especially with respect to their reaction to the stimulation. The effect of neutrophile stimulation in vitro with an inactivated vaccine of Serratia marcescens was higher and more stable than that with a single inhalation of prodigiosan. The prevalence of the least pathway providing increased resistance of the phagocytosing cells to infection in the population of the Far North might be the cause of a significant risk of infectious diseases in them.
D000328:Adult; D003081:Cold Climate; D006801:Humans; D007109:Immunity; D066298:In Vitro Techniques; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D009580:Nitroblue Tetrazolium; D010587:Phagocytosis / Q000187:drug effects; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011354:Prodigiozan / Q000494:pharmacology*; D012706:Serratia marcescens / Q000472:pathogenicity*; D012800:Siberia
D011135:Polysaccharides, Bacterial; D009580:Nitroblue Tetrazolium; D011354:Prodigiozan
Ob otsenke funktsiĭ neĭtrofilov cheloveka po ikh reaktsii na bakteriĭnyĭ stimul.