The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle.
The effects of danazol on pulsatile luteinizing hormone (LH) release, basal LH and follicle-stimulating hormone serum levels, gonadotropin release induced by estradiol (E2) and gonadotropin-releasing hormone were examined in five eugonadal women. Danazol administration resulted in a significant suppression of follicle-stimulating hormone serum levels. LH concentrations and LH pulse frequency appeared to be reduced, but these changes did not reach statistical significance. The pituitary response to exogenous gonadotropin-releasing hormone was not altered. The stimulatory effect of E2 on LH secretion was completely abolished in one subject, severely diminished in three subjects, and unchanged in one subject. In addition, the time course of this response was altered. Serum prolactin concentrations were lowered, whereas basal E2 and progesterone levels did not seem to be affected.
D000328:Adult; D001831:Body Temperature / Q000187:drug effects; D003613:Danazol / Q000494:pharmacology*; D004958:Estradiol / Q000378:metabolism; D005260:Female; D005498:Follicular Phase / Q000187:drug effects*; D006062:Gonadotropins / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008598:Menstruation / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D010906:Pituitary Hormone-Releasing Hormones / Q000502:physiology; D011245:Pregnadienes / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism
D006062:Gonadotropins; D010906:Pituitary Hormone-Releasing Hormones; D011245:Pregnadienes; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D003613:Danazol