The peritoneal reaction to the translocated copper intrauterine device in women and female rats.
The observation of a very severe peritoneal reaction to translocated copper-bearing devices in five women necessitated operative removal. Three Copper-T (Ortho Gyne-T, Ortho, Saunderton, High Wycombe, England) and two Copper-7 (Gravigard, Searle, High Wycombe, England) devices were involved. Similarly severe peritoneal reactions were noted in 90% of female rats who had small-sized modified copper devices inserted into their peritoneal cavities. In a control group of rats with the same device but without a copper wire, mild adhesions were observed in the majority (85%), and none had a severe peritoneal reaction. It seems evident that the severe peritoneal reaction is induced by the copper wire in both women and female rats.
D000818:Animals; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology*; D006801:Humans; D007435:Intrauterine Devices, Copper / Q000009:adverse effects*; D009336:Necrosis; D010529:Peritoneal Cavity; D010537:Peritoneum / Q000473:pathology; D051381:Rats; D000267:Tissue Adhesions / Q000473:pathology