The influence of oral immunization on local and systemic immune responses to heterologous antigens.
Oral immunization with 25 mg/day of ovalbumin resulted in a number of changes in non-specific immune responsiveness, including increases in antibody produced to T-dependent but not T-independent antigens and the abrogation of tolerance induced by both oral and intravenous routes. The effect was transient, sex- and strain-dependent. Evidence suggests that it is a consequence of cell-mediated immunity to the oral immunogen.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D004032:Diet; D005260:Female; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed; D007108:Immune Tolerance; D007114:Immunization; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010047:Ovalbumin / Q000276:immunology*; D012737:Sex Factors
D000941:Antigens; D007074:Immunoglobulin G; D010047:Ovalbumin