title: A comparison of a combination of penbutolol and frusemide with the two compounds individually in the treatment of hypertension.
abstract: Forty-one patients completed a randomized, double-blind, between-group comparison of a combination of penbutolol and frusemide, with penbutolol alone, and frusemide alone in the management of mild to moderate essential hypertension. The results suggest that the combination caused a superior reduction in systolic and diastolic pressure compared with penbutolol and a superior reduction in systolic blood pressure compared with frusemide.
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D010394:Penbutolol / Q000008:administration & dosage*; D011412:Propanolamines / Q000008:administration & dosage*; D011897:Random Allocation
chemical_list: D011412:Propanolamines; D010394:Penbutolol; D005665:Furosemide