Effect of histamine on leukocyte migration tests in vertebrates. II. Study of the lack of species specificity of leukocyte inhibiting factor--production inhibitor (LIF-PI).
Immune regulatory effects of histamine are now well established. We have previously demonstrated that human T lymphocytes having histamine receptors, produce a soluble factor inhibiting the production of LIF. In this present paper we have shown that production and function of this factor is not species specific. Indeed the leukocyte inhibiting factor-production inhibitor (LIF-PI) produced by human, guinea pig or dog lymphocytes inhibits the production of LIF by human, guinea pig and murine lymphocytes to a similar extent. This property allows for easier testing of LIF-PI particularly from human subjects.
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D004285:Dogs; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007108:Immune Tolerance; D007961:Leukocyte Migration-Inhibitory Factors / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008222:Lymphokines / Q000096:biosynthesis*; D051379:Mice; D011968:Receptors, Histamine / Q000032:analysis; D013045:Species Specificity
D001500:BCG Vaccine; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D011968:Receptors, Histamine; D003208:Concanavalin A; D006632:Histamine