title: [Immunologic principles of allergic contact eczema].
abstract: Epicutaneous sensitization against contact allergens is mediated by T lymphocytes. For activation of these T lymphocytes antigen has to be presented in association with Ia by Langerhans cells. A further signal for activation of this cell is provided by interleukin 2. The production of interleukin 2 is induced by interleukin 1, which can be also produced by keratinocytes (epidermal T-cell activating factor, ETAF). The activated T-effector lymphocyte is controlled by T-suppressor lymphocyte subpopulations. The interaction between these cells is genetically controlled. A defect in this genetic control may play a role in contact sensitization against various allergens.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D003888:Desensitization, Immunologic; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007375:Interleukin-1 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D012867:Skin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007375:Interleukin-1; D007376:Interleukin-2; D008222:Lymphokines
vernacular_title: Immunologische Grundlagen des allergischen Kontaktekzems.