[Gluten-sensitive enteropathy--in the light of new clinical and pathogenetic aspects].
The corn protein gluten causes the gluten-sensitive enteropathy in susceptible persons (HLA-antigens). The diagnosis is made on the basis of the morphological criteria of villous atrophy of the jejunal mucosa and the clinical observation that the malabsorption can be healed by a gluten-free diet. The disease, which occurs in children and adults, is a distinct entity. Life-long adherence to a gluten-free diet is difficult. Intentional or unintentional reintroduction of gluten often causes masked disease states. These are best classified on the basis of electron-microscopy study of the jejunal biopsy. We propose a new classification of the phases of remission. A group of diseases exist which are closely related to gluten-sensitive enteropathy. Frequently villous atrophy is detectable. However, the disease does not respond to a gluten-free diet. The pathophysiology of these diseases is at present unclear. Diseases involving autoimmune processes also appear to be associated with gluten-sensitive enteropathy. The common factor is probably an immuno-genetic defect. This is supported by the existence of common HLA-antigen constellations. Gluten has been characterised in vitro as a lectin with oligomannose specificity. This provides a new pathomechanism for the gluten induced enterocytic destruction.
D002446:Celiac Disease / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism*; D005983:Glutens / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007413:Intestinal Mucosa / Q000648:ultrastructure; D008286:Malabsorption Syndromes / Q000209:etiology
D006023:Glycoproteins; D006680:HLA Antigens; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D005983:Glutens
Glutensensitive Enteropathie - im Lichte neuer klinischer und pathogenetischer Aspekte.