title: Creutzfeld-Jakob disease in the province of Siena: two cases transmitted to monkeys.
abstract: Two cases of histopathologically documented Creutzfeldt-Jakob disease were observed in the same area of the province of Siena in 1974-1975. The transmission of the disease was obtained through brain homogenates and lymphnodes in one of the two cases. This confirms that the agent is present in other tissues besides the brain and underlines further the analogies between Creutzfeld-Jakob disease and scrapie.
mesh_terms: D000368:Aged; D000818:Animals; D002427:Cebidae / Q000382:microbiology*; D002428:Cebus / Q000382:microbiology; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000635:transmission*; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D012453:Saimiri / Q000382:microbiology