title: In vitro study of drug sensitivity of Plasmodium falciparum: evaluation of a new semi-micro test.
abstract: A modification of Rieckmann's microtechnique was used to determine the drug sensitivity of Plasmodium falciparum. The technique was found to be reliable and adequately sensitive with either blood from a malarial patient or strains of P. falciparum from in vitro continuous culture, with a success rate of 50%. Minor variations in the method had little influence on the results. Inhibition of maturation of parasites was compared with the inhibition of increase in parasitemia.
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D015767:Mefloquine; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D011804:Quinolines; D002738:Chloroquine; D011803:Quinine; D015767:Mefloquine