Plasmid coding for drug resistance and production of heat-labile and heat-stable toxins harbored by an Escherichia coli strain of human origin.
In a study of enterotoxigenic strains of Escherichia coli isolated from children with diarrhea in São Paulo, Brazil, a new enterotoxin and antibiotic resistance plasmid that carries heat-labile toxin, heat-stable toxin, and drug resistance genes was found. This is the first such plasmid to be found in a human strain of E. coli. The plasmid is nonconjugative, has a molecular weight of at least 54 x 10(6), and is mobilized by the R plasmid present in the host strain.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001427:Bacterial Toxins; D003087:Colicins / Q000235:genetics; D003227:Conjugation, Genetic; D004768:Enterotoxins / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D029968:Escherichia coli Proteins; D006801:Humans; D008970:Molecular Weight; D010957:Plasmids; D011815:R Factors
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D003087:Colicins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C034151:heat stable toxin (E coli); C027538:heat-labile enterotoxin, E coli