title: [Molecular nature of direct gene mutations induced by gamma and ultraviolet irradiation in Saccharomyces cerevisiae yeasts].
abstract: The spectrum of gamma- and UV-induced mutations for ADE2 locus of the yeast Saccharomyces cerevisiae was determined as follows (respectively): 27 and 41% GC leads to AT transitions, 8 and 11% AT leads to GC transitions, 59 and 40% transversions, 6 and 8% frameshifts. Our results indicate a specificity of UV-light for GC leads to AT transitions. Experimental data are discussed in a view of molecular mechanisms of radiation mutagenesis.
mesh_terms: D000225:Adenine / Q000528:radiation effects; D001483:Base Sequence; D003596:Cytosine / Q000528:radiation effects; D005720:Gamma Rays; D005796:Genes / Q000528:radiation effects*; D006147:Guanine / Q000528:radiation effects; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000528:radiation effects*; D013941:Thymine / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D006147:Guanine; D003596:Cytosine; D000225:Adenine; D013941:Thymine
vernacular_title: Molekuliarnaia priroda priamykh gennykh mutatsii, indutsirovannykh gamma i ul'trafioletovym izlucheniem u drozhzheĭ Saccharomyces cerevisiae.