title: [Double-blind study with tiaprofenic acid (Surgam) against ibuprofen (Brufen) in patients with arthroses of the knee and hip joints].
abstract: 60 patients with osteoarthritis of the hips or knees were selected for our randomized double blind trial comparing efficacy and safety of the two propionic acid derivates tiaprofenic acid (daily dose 600 mg) and ibuprofen (daily dose 1200 mg) for 21 days. Criterias for evaluation were different pain qualities, morning-stiffness, 15-meter-walking-time, joint circumference, heel-seat-distance, intermalleolar and intercondylardistance. The good therapeutic effect was equal for both substances, drop-outs because of side effects were necessary for 2 patients of each group.
mesh_terms: D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006621:Hip Joint / Q000187:drug effects*; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D007592:Joint Diseases / Q000188:drug therapy*; D007719:Knee Joint / Q000187:drug effects*; D011422:Propionates / Q000627:therapeutic use*
chemical_list: D011422:Propionates; C021270:tiaprofenic acid; D007052:Ibuprofen
vernacular_title: Doppelblindstudie mit Tiaprofensäure (Surgam) gegen Ibuprofen (Brufen) bei Patienten mit Arthrosen der Knie- und Hüftgelenke.