Synthesis and catabolism of PGE2 by a nephroblastoma associated with hypercalcemia without bone metastases.
PGE2 overproduction by a nephroblastoma associated with hypercalcemia was clearly demonstrated in a 2-month-old girl. Compared with normal tissue, tumor showed greater phospholipase A2 and PGE2 synthetase activities but metabolized PGE2 at a faster rate. Of the enzymes involved in PGE2 synthesis, those which transform arachidonic acid into PGE2 seem to be more active.
D001859:Bone Neoplasms / Q000556:secondary; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000378:metabolism*; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism; D011863:Radioimmunoassay; D009396:Wilms Tumor / Q000150:complications / Q000378:metabolism*
D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D011451:Prostaglandin-Endoperoxide Synthases; D010741:Phospholipases A; D054467:Phospholipases A2; D015232:Dinoprostone