Systemic and neuropathologic effects of E. coli endotoxin in neonatal dogs.
The acute systemic and neuropathologic effects of E. coli endotoxin were determined in neonatal dogs. Administration of sublethal (LD0), moderate (LD50), or lethal (LD100) doses of endotoxin produced significant arterial hypotension, metabolic (lactic) acidosis, and hypoglycemia. Neuropathologic changes consisted of widespread inflammation in both grey and white matter; however, necrotic lesions were found only in forebrain white matter.
D000138:Acidosis / Q000209:etiology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000473:pathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D004926:Escherichia coli; D007003:Hypoglycemia / Q000209:etiology; D007022:Hypotension / Q000209:etiology; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D007928:Lethal Dose 50; D009336:Necrosis
D004731:Endotoxins; D007773:Lactates; D019344:Lactic Acid