title: Genes of the major histocompatibility complex in mouse and man.
abstract: The genes of the major histocompatibility complex code for cell-surface molecules that play an important role in the generation of the immune response. These genes and molecules have been studied intensively over the last five decades by geneticists, biochemists, and immunologists, but only recently has the isolation of the genes by molecular biologists facilitated their precise characterization. Many surprising findings have been made concerning their structure, multiplicity, organization, function, and evolution.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D005796:Genes; D006183:H-2 Antigens / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006649:Histocompatibility Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D051379:Mice; D011110:Polymorphism, Genetic; D011487:Protein Conformation
chemical_list: D006183:H-2 Antigens; D006680:HLA Antigens; D006649:Histocompatibility Antigens