Failure to transfer insulitis to athymic recipients using BB/W rat lymphoid tissue transplants.
Lymphocytes from acutely diabetic BB/W rats were transplanted into SWR/JM nu/nu athymic mice and nu/nu athymic rats. Despite the use of a wide variety of dose regimens and pretreatments, no recipient developed either insulitis, hyperglycemia, or glucose intolerance. These data contradict earlier reports of successful transfer of insulitis using similar methodology.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D005260:Female; D005951:Glucose Tolerance Test; D007515:Islets of Langerhans / Q000473:pathology; D008221:Lymphoid Tissue / Q000637:transplantation*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D010195:Pancreatitis / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains