title: Beneficial effect of pre-transplant splenectomy for leukopenia in primary cadaver kidney transplants.
abstract: Pre-transplant splenectomy is controversial. We compared 21 nondiabetic, transfused recipients of first cadaver kidney grafts who underwent pre-transplant splenectomy for steroid-resistant leukopenia to 114 without steroid-resistant leukopenia. Kidney graft survivals at 2 years were 80.2 plus or minus 8.9 and 48.5 plus or minus 5.3 per cent, respectively (p less than 0.05). The 2-year actuarial patient survivals were not significantly different (89.6 plus or minus 7.0 versus 87.8 plus or minus 3.9 per cent). Azathioprine doses and serum creatinine levels at 1 year were not significantly different. Pre-transplant splenectomy for steroid-resistant leukopenia resulted in a significant decrease in kidney graft losses owing to rejection without an increased risk of death of sepsis or thromboembolism.
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D002102:Cadaver; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D007970:Leukopenia / Q000628:therapy*; D013156:Splenectomy
chemical_list: D001379:Azathioprine