Comparative study of prostaglandin I2 (PG I2) and thromboxane A2 (TXA2) synthetase inhibitor (OKY-1581) on hemodynamics in pregnant dogs.
Effects of intravenous injections of prostaglandin I2 (PG I2) and thromboxane A2 (TXA2) synthetase inhibitor (OKY-1581) on mean arterial pressure (MAP), cardiac output (CO), heart rate (HR), renal blood flow (RBF), and uterine blood flow (UBF) were investigated in the anesthetized pregnant dog. A dose-dependent fall in MAP was observed with these two agents. HR was almost unchanged by both PG I2 and TXA2 synthetase inhibitor. PG I2 and TXA2 synthetase inhibitor produced increases in CO and RBF in a dose-dependent manner. PG I2 caused a dose-dependent decrease in UBF, while TXA2 synthetase inhibitor was followed by an insignificant decrease in UBF. PG I2 and TXA2 synthetase inhibitor did not induce any increase in intrauterine pressure (IUP). The possibility of treatment of pregnancy-induced hypertension with PG I2 or TXA2 synthetase inhibitor is discussed.
D000179:Acrylates / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004562:Electrocardiography; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008689:Methacrylates / Q000494:pharmacology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011453:Prostaglandins / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D000179:Acrylates; D008689:Methacrylates; D011453:Prostaglandins; D013928:Thromboxane A2; C031517:2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid; D011464:Epoprostenol; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase