Infrared contact coagulation: a new approach for local hyperthermic therapy of solid animal tumors.
Infrared contact coagulation (ICC) was evaluated in 3 different tumor models. 56-94% of all tumor-bearing rats, hamsters or mice were cured by ICC, whereas 100% of the controls died. The possibility that long-lasting immunological resistance might develop against the tumor after ICC was investigated by repeated tumor challenge. Cytotoxicity against tumor cells of host thymocytes and splenocytes following ICC was demonstrated in a Winn assay. The production of a mainly T-cell-dependent immune response could be due to ICC-induced antigenic changes in the tumor cells.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000628:therapy*; D006224:Cricetinae; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006979:Hyperthermia, Induced / Q000379:methods*; D007259:Infrared Rays; D008175:Lung Neoplasms / Q000628:therapy*; D008545:Melanoma / Q000628:therapy*; D008647:Mesocricetus; D051381:Rats; D013601:T-Lymphocytes / Q000166:cytology
D000949:Histocompatibility Antigens Class II