title: Alterations in purine salvage and hypoxanthine levels in granulation tissue during skin wound repair.
abstract: We report the levels of hypoxanthine in rabbit skin granulation tissue, harvested at different postwound intervals and from various locations within the wounds. The effect of full-thickness autogenous skin grafts on hypoxanthine levels has also been examined. The levels of inosine, xanthine, adenosine 5'-monophosphate, and inosine 5'-monophosphate are reported as well. The correlation between the level of these compounds and the healing process suggests they may be useful indicators of the extent of tissue damage.
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006097:Granulation Tissue / Q000378:metabolism*; D007042:Hypoxanthines / Q000032:analysis / Q000378:metabolism*; D007288:Inosine / Q000032:analysis; D011685:Purine Nucleotides / Q000378:metabolism*; D011817:Rabbits; D012867:Skin / Q000293:injuries / Q000378:metabolism; D016038:Skin Transplantation; D014945:Wound Healing; D019820:Xanthine; D014970:Xanthines / Q000032:analysis
chemical_list: D007042:Hypoxanthines; D011685:Purine Nucleotides; D014970:Xanthines; D019820:Xanthine; D007288:Inosine