Some historical aspects of N-aryl carcinogens and their metabolic activation.
This limited review of the early studies on the activation of the N-aryl carcinogens was written to provide a background for the current research to be presented at this conference on carcinogenesis by N-aryl compounds. Since the work of the past 10 years is too recent to be judged in a historical sense and because those data are much better known by current investigators, this review is generally limited to data up to 1972.
D015073:2-Acetylaminofluorene / Q000378:metabolism; D000588:Amines / Q000633:toxicity*; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity; D001711:Biotransformation; D002273:Carcinogens / Q000266:history* / Q000378:metabolism; D004396:Coloring Agents / Q000633:toxicity; D005858:Germany; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008099:Liver / Q000378:metabolism; D011485:Protein Binding; D051381:Rats
D000588:Amines; D001391:Azo Compounds; D002273:Carcinogens; D004396:Coloring Agents; D015073:2-Acetylaminofluorene