title: A new delineation of the congeries of osteoarthritis.
abstract: New concepts of osteoarthritis (OA) are reviewed as preliminary to establishing a new classification of OA, defining sub-groups of OA based on combined biochemical and clinical data. The biochemical data are derived from assays of serum proteins--transferrin, ceruloplasmin, albumin, a1-acid glycoprotein, a1-antitrypsin, immunoglobulins A, G, and M. Standard clinical techniques are followed to provide clinical data, including medical history, physical examination, x-ray studies and routine biochemical tests. Genetic polymorphism is proposed as an explanation for subsets of OA. Extensive family history data is important in establishing connections.
mesh_terms: D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D006621:Hip Joint; D006801:Humans; D007719:Knee Joint; D008297:Male; D009961:Orosomucoid / Q000378:metabolism; D010003:Osteoarthritis / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D012709:Serum Albumin / Q000378:metabolism; D013128:Spinal Osteophytosis / Q000145:classification; D014168:Transferrin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D009961:Orosomucoid; D012709:Serum Albumin; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D002570:Ceruloplasmin