Lysosomal enzymes and acute gastric erosions: a review.
Lysosomal enzymes, acid hydrolases with acid pH optimum, are involved in cell death. Recent evidence has also indicated a role for these enzymes in the pathogenesis of acute gastric erosions. Aspirin-acid, bile-acid and bacterial peritonitis cause lysosomal instability, the release of lysosomal enzymes and acute gastric erosions. Prostaglandins such as 16,16-dimethyl prostaglandin E2 will stabilize lysosomal membranes, decrease lysosomal enzyme release and prevent acute gastric erosions.
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006867:Hydrolases / Q000096:biosynthesis; D007425:Intracellular Membranes / Q000187:drug effects; D008247:Lysosomes / Q000201:enzymology* / Q000648:ultrastructure; D011453:Prostaglandins / Q000494:pharmacology; D013276:Stomach Ulcer / Q000209:etiology* / Q000473:pathology
D011453:Prostaglandins; D006867:Hydrolases