Leucocyte adherence inhibition and carcinoembryonic antigen in combination for diagnosis of colorectal cancer.
A combination of leucocyte adherence (LAI) and carcinoembryonic antigen (CEA) diagnosed colorectal carcinoma with 91% sensitivity and 68% specificity. Relative operating characteristic (ROC) analysis was used to calculate the cutoff points for optimum detectability in a group of 159 patients with bowel symptoms who were investigated by endoscopy and radiology. Combining LAI and CEA would be likely to reduce the chance of missed diagnosis of colorectal carcinoma when x-ray and colonoscopic findings are equivocal.
D000236:Adenoma / Q000175:diagnosis; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003108:Colonic Diseases / Q000175:diagnosis; D003110:Colonic Neoplasms / Q000175:diagnosis*; D005189:False Positive Reactions; D006801:Humans; D007158:Immunologic Techniques; D007957:Leukocyte Adherence Inhibition Test; D012004:Rectal Neoplasms / Q000175:diagnosis*
D002272:Carcinoembryonic Antigen