Alterations in purine salvage and hypoxanthine levels in granulation tissue during skin wound repair.
We report the levels of hypoxanthine in rabbit skin granulation tissue, harvested at different postwound intervals and from various locations within the wounds. The effect of full-thickness autogenous skin grafts on hypoxanthine levels has also been examined. The levels of inosine, xanthine, adenosine 5'-monophosphate, and inosine 5'-monophosphate are reported as well. The correlation between the level of these compounds and the healing process suggests they may be useful indicators of the extent of tissue damage.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006097:Granulation Tissue / Q000378:metabolism*; D007042:Hypoxanthines / Q000032:analysis / Q000378:metabolism*; D007288:Inosine / Q000032:analysis; D011685:Purine Nucleotides / Q000378:metabolism*; D011817:Rabbits; D012867:Skin / Q000293:injuries / Q000378:metabolism; D016038:Skin Transplantation; D014945:Wound Healing; D019820:Xanthine; D014970:Xanthines / Q000032:analysis
D007042:Hypoxanthines; D011685:Purine Nucleotides; D014970:Xanthines; D019820:Xanthine; D007288:Inosine