[The effect of diucifon on the hematopoietic and immune systems in normal and irradiated organisms].
It was shown that irradiation of mice with the dose of 4 Gy affected the immune and haemopoietic systems. Diucyphone injected on days 6-8 after irradiation favoured the production of antibodies in the spleen, increased the yield of exogenous splenic colonies and corrected differentiation of the haemopoietic stem cells. In the normal body, diucyphone decreased the colony-forming activity and did not change the haemopoietic stem cell differentiation.
D000276:Adjuvants, Immunologic; D000818:Animals; D003114:Colony-Forming Units Assay; D004338:Drug Combinations / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000473:pathology; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000276:immunology* / Q000473:pathology; D013450:Sulfones / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D013450:Sulfones; C023367:diucifon; D014498:Uracil
Vozdeĭstvie diutsifona na sistemu krovetvoreniia i immuniteta v normal'nom i obluchennom organizme.