[Prevention of the provoking action of insulin on oxygen poisoning and the preservation of specific properties of the preparation under hyperbaric oxygenation].
It has been shown in experiments on rats exposed to oxygen under a pressure of 4558.5 PA (4.5 at. abs) for 1 h that phentolamine (5 mg/kg) and etiron (20 mg/kg) reduced or prevented the provoking action of insulin (3 units/kg) on the convulsant oxygen syndrome and pulmonary involvement. Inderal (1.5 mg/kg) was effective only as regards lung defence, whereas diazepam (5 mg/kg) intensified pulmonary involvement and displayed an insignificant anticonvulsant action. Phentolamine, etiron and diazepam applied in conjunction with insulin promoted the preservation or potentiation of the hypoglycemic and hypokalemic effects characteristic for insulin. In this case inderal provoked hypoglycemia and prevented oxygen-induced hyperkalemia.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D006931:Hyperbaric Oxygenation; D007328:Insulin / Q000494:pharmacology*; D007329:Insulin Antagonists / Q000494:pharmacology*; D008297:Male; D010100:Oxygen / Q000506:poisoning*; D011188:Potassium / Q000097:blood; D051381:Rats
D000975:Antioxidants; D001786:Blood Glucose; D007328:Insulin; D007329:Insulin Antagonists; D011188:Potassium; D010100:Oxygen
O preduprezhdenii provotsiruiushchego deĭstviia insulina na kislorodnoe otravlenie i sokhranenii spetsificheskikh svoĭstv preparata v usloviialkh giperbaricheskoĭ oksigenatsii.