[Animal experiment studies of the synergism between acylureido- penicillins and immunoglobulin G].
Animal experiments revealed that the simultaneous administration of mezlocillin and immunoglobulin G (IgG) caused a highly significant increase in the elimination of beta-lactamase producing strains of the species E.coli or Proteus spp. as compared to a mezlocillin-monotherapy. This synergistic effect is due to an inhibition of the enzymic activity of the beta-lactamases by antibodies as could be demonstrated by using enzyme crude extracts. In vivo studies on the stimulation of phagocytosis revealed that only an intact 7S IgG-preparation obtained by reduction and alkylation stimulated phagocytosis, whereas cleaved or acid-treated products were ineffective.
D000818:Animals; D004195:Disease Models, Animal; D004357:Drug Synergism; D004755:Enterobacteriaceae / Q000201:enzymology / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000628:therapy*; D005260:Female; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008802:Mezlocillin / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D001618:beta-Lactamases / Q000096:biosynthesis
D007074:Immunoglobulin G; D001618:beta-Lactamases; D008802:Mezlocillin
Tierexperimentelle Untersuchungen zum Synergismus zwischen Acylureido-Penicillinen und Immunoglobulin G.