Sural nerve immune deposits in polyneuropathy as a remote effect of malignancy.
Sural nerves from six patients with polyneuropathy as a remote accompaniment of malignancy were studied by light microscopy, immunofluorescence, electron microscopy, and immuno-electron microscopy. Sural nerves also were studied in twelve control patients with malignant diseases without peripheral neuropathy and in fifteen with neuropathy associated with nonmalignant conditions. Only nerves from the first group of six patients showed immune deposits of immunoglobulin M, C3, and C1q as granular or confluent layers in the inner laminae of the perineurium as well as in and around endoneural capillaries. The findings are similar to those in published studies of Waldenström's macroglobulinemia, chronic relapsing polyneuropathy, and neuropathy of monoclonal gammopathy and extend the list of conditions to include several forms of carcinoma and Hodgkin's disease.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis*; D003166:Complement Activating Enzymes / Q000032:analysis; D015922:Complement C1q; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D011115:Polyneuropathies / Q000276:immunology*; D013127:Spinal Nerves / Q000276:immunology*; D013497:Sural Nerve / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007136:Immunoglobulins; D015922:Complement C1q; D003166:Complement Activating Enzymes