[Adjuvant potential of vitamin E in the induction of experimental allergic encephalomyelitis: histological aspects].
In this study we report the effect of Vit. E, as an immunostimulating factor, on the induction of Experimental Allergic Encephalomyelitis in Lewis rat. The animals were inoculated intracutaneously in the plantar areas with emulsion of isologous spinal cord suspensed in Incomplete Freund's Adjuvant (IFI) and Vit. E. Histologic examination revealed the basic lesion of a perivenous cuff of mononuclear cells and small areas of demyelinated axons. The clinical signes are graded in order to the time of induction. It is possible an action of "adjuvanticity" of Vit. E on the various cells involved in the immune response by cell transformation and moltiplication.
D000276:Adjuvants, Immunologic; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000473:pathology*; D009000:Monocytes / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000473:pathology; D014810:Vitamin E / Q000276:immunology*
D000276:Adjuvants, Immunologic; D014810:Vitamin E
Adiuvanticita' della vitamina E nell'induzione della encefalite allergica sperimentale: aspetti istologici.