Beta-adrenergic binding sites in fetal rat brain.
The ontogeny of beta-adrenergic binding sites was studied in forebrain homogenates from male and female rats. Specific [3H]dihydroalprenolol binding was defined by the difference between binding in the presence and in the absence of 330 nM (+)oxprenolol. Significant binding was detected at prenatal stages. The dissociation constants (KD) of [3H]dihydroalprenolol binding were similar at gestational day (GD) 19 3/4 and postnatal day (PN) 31. Binding was first detected in forebrain at GD 15 3/4. The amount of binding sites increased until PN 31, when adult values were reached. No sex differences could be detected at any of the stages tested (GD 19 3/4-PN 31).
D000375:Aging; D000818:Animals; D001921:Brain / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D004082:Dihydroalprenolol / Q000378:metabolism; D005260:Female; D005333:Fetus; D005865:Gestational Age; D007700:Kinetics; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
D011943:Receptors, Adrenergic, beta; D004082:Dihydroalprenolol