Interleukin 1 enhances synovial cell hyaluronate synthesis.
Interleukin 1 enhances proliferation of murine thymocytes in the presence of lectins, and is also known to stimulate the release of prostaglandins and neutral proteases from a variety of cell types. We have previously shown that a factor isolated from the culture media of disaggregated lining cells of the human synovial membrane was indistinguishable from monocyte-derived interleukin 1. We report here that interleukin 1 from either source stimulates hyaluronate synthesis by synovial membrane cells. Upon gel filtration or isoelectric focusing of synovial cell supernatants, the hyaluronate-stimulatory activity co-fractionates with the interleukin 1 activity. Enhanced cell secretion of hyaluronate is a newly described metabolic effect of interleukin 1.
D001681:Biological Assay; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D015232:Dinoprostone; D006801:Humans; D006820:Hyaluronic Acid / Q000096:biosynthesis*; D007375:Interleukin-1 / Q000302:isolation & purification / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
D007375:Interleukin-1; D011458:Prostaglandins E; D006820:Hyaluronic Acid; D015232:Dinoprostone