[Artificial blood. Experimental studies on fluorocarbons as chemical blood substitutes].
Fluorocarbonates are organic compounds capable of carrying oxygen and surrendering it to tissues by means of biological sound modalities. Experimentation of an emulsion consisting of perfluorotripropylamine and perfluorodecaline (Fluosol DA 20%) as a blood substitute is reported. Acute (Ht less than 1%) and chronic morphological (Ht = 15%) studies were performed on rats, and a semi-acute biochemical and morphological protocol (Ht = 21%) was experimented in pigs. The first signs of altered cerebral electrical activity occurred at Ht = 2% in the acute experiments, and death due to respiratory arrest took pace at Ht = 0.5%. In the semiacute and chronic experiments, widespread infiltration of fluorocarbonic micelles was noted on histological and electron microscope lung and liver preparations.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001692:Biological Transport; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes; D002249:Carbon Monoxide Poisoning / Q000628:therapy; D002496:Central Venous Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004338:Drug Combinations / Q000494:pharmacology; D004562:Electrocardiography; D004569:Electroencephalography; D004576:Electromyography; D004655:Emulsions; D005466:Fluorocarbons / Q000378:metabolism / Q000494:pharmacology*; D005780:Gelatin / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006438:Hemodilution; D006470:Hemorrhage / Q000628:therapy; D006895:Hydroxyethyl Starch Derivatives; D008099:Liver / Q000187:drug effects; D012157:Mononuclear Phagocyte System / Q000187:drug effects; D010101:Oxygen Consumption; D011517:Prothrombin Time; D051381:Rats; D014021:Tissue Preservation; D014180:Transplantation
D001786:Blood Glucose; D001802:Blood Substitutes; D004338:Drug Combinations; D004655:Emulsions; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C008807:perfluorotributylamine; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D005780:Gelatin
I1 sangue artificiale. Ricerche sperimentali sull'uso dei fluorocarbonati come succedanei chimici del sangue.