A unique series of lymphomas related to the Ly-1+ lineage of B lymphocyte differentiation.
Six new B lineage lymphomas of NFS mice established in primary tissue culture were examined for a number of phenotypic, functional, virologic, and molecular genetic characteristics. Two of the tumors and their cloned derivatives bore surface markers characteristic of B cells, whereas four tumors resembled pre-B cells. One of the B cell and two of the pre-B cell lymphomas had rearrangements of both heavy and light chain immunoglobulin genes, confirming their designation as B-lineage lymphomas. All the tumors but one were Ly-1+, indicating that Ly-1 may be expressed by some pre-B cells as well as some B cells. In addition, one pre-B cell lymphoma was Mac-1+. MCF murine leukemia viruses obtained from two of the tumors did not accelerate development of B-lineage lymphomas in NFS mice.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002472:Cell Transformation, Viral; D002999:Clone Cells / Q000166:cytology / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000235:genetics; D007621:Karyotyping; D009052:Leukemia Virus, Murine; D008223:Lymphoma / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D010641:Phenotype
D000950:Antigens, Ly; D000954:Antigens, Surface; D007075:Immunoglobulin M; D007136:Immunoglobulins