title: Anti-streptococcal cell membrane and anti-human glomerular basement membrane titers in sera of patients with poststreptococcal acute glomerulonephritis and anaphylactoid purpura.
abstract: To clarify the immunological mechanisms in poststreptococcal acute glomeulonephritis (PSAGN) and anaphylactoid purpura (AP), anti-streptococcal cell membrane (anti-SCM) and anti-human glomerular basement membrane (anti-GBM) titers in the sera of patients with PSAGN and AP were determined by passive hemagglutination with chromic chloride-treated sheep erythrocytes. Sodium lauryl sulfate (SLS) soluble SCM and collagenase soluble GBM were used as soluble antigens. Positive anti-SCM titers (greater than 1:8) were demonstrated in 10 of 14 patients (71.4%) with PSAGN and in 4 of 9 patients (44.4%) with AP with evidence of antecedent streptococcal infection. Two of 4 patients with AP without evidence of antecedent streptococcal infection had positive anti-SCM titers. No correlation was noted between anti-streptolysin O (ASO) titers and anti-SCM titers in patients with PSAGN or AP, but many patients with high ASO titers also had high anti-SCM titers. No positive anti-GBM reactions were detected in patients with PSAGN or AP. No cross-reactions were noted between SLS soluble SCM and collagenase soluble GBM.
mesh_terms: D000208:Acute Disease; D000989:Antistreptolysin / Q000032:analysis; D001485:Basement Membrane / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D005921:Glomerulonephritis / Q000276:immunology*; D006386:Hemagglutination Tests; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology*; D013290:Streptococcal Infections / Q000150:complications*; D013297:Streptococcus pyogenes / Q000276:immunology*
chemical_list: D000989:Antistreptolysin