title: The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat.
abstract: The distribution of serotonin-immunoreactive varicosities in the paraventricular (PVH) and supraoptic (SO) nuclei was charted in normal immunohistochemical material and the probable cells of origin of these projections were identified using a combined retrograde transport-immunohistochemical method. The density of serotonergic fibers in the PVH and the SO is quite low relative to that in the immediately surrounding neuropil, in striking contrast to noradrenergic inputs to the nuclei. Immunoreactive fibers are concentrated in specific parts of the parvocellular division of the PVH, whereas in the magnocellular division of the nucleus, and in the SO, they are found mostly in regions where oxytocinergic cells predominate. These projections appear to arise from 3 distinct serotonergic cell groups (B7, B8 and B9) in the midbrain.
mesh_terms: D000344:Afferent Pathways / Q000033:anatomy & histology; D000818:Animals; D005455:Fluorescent Antibody Technique; D008297:Male; D009412:Nerve Fibers / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure; D010286:Paraventricular Hypothalamic Nucleus / Q000033:anatomy & histology*; D011903:Raphe Nuclei / Q000033:anatomy & histology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013495:Supraoptic Nucleus / Q000033:anatomy & histology*; D013787:Thalamic Nuclei / Q000033:anatomy & histology
chemical_list: D012701:Serotonin