title: Plasmodium falciparum: comparison of in vitro growth of knobby and knobless isolates.
abstract: Variants (K-) of three strains of Plasmodium falciparum which do not produce the erythrocyte surface alterations that have been called knobs have been compared with their wildtype knobby (K+) parents. The K- variants achieve higher parasitemias, incorporate radiolabeled isoleucine more rapidly, and produce a higher percentage of multiply-infected cells than do their K+ parents. Nevertheless, immune owl monkey sera cause approximately the same percentage inhibition of growth of both K+ and K- organisms when included in the growth medium at a 1% concentration.
mesh_terms: D000818:Animals; D001029:Aotus trivirgatus; D007106:Immune Sera / Q000494:pharmacology; D066298:In Vitro Techniques; D007532:Isoleucine / Q000378:metabolism; D008288:Malaria / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification
chemical_list: D007106:Immune Sera; D007532:Isoleucine