title: An overview of two comparative multicentre trials with halometasone/triclosan cream in acute superficial bacterial skin infections.
abstract: Two multicentre, open comparative trials were carried out by seven dermatologists in Spain and Yugoslavia in 220 evaluable patients with acute superficial skin infections. In these trials halometasone/triclosan cream showed an overall success rate ('good' and 'very good' results) of 84% as against 60% obtained with the comparative preparations. With regard to therapeutic effect halometasone/triclosan cream proved significantly superior to fluocinolone acetonide/neomycin cream (p less than 0.001) and yielded a higher overall success rate, although not statistically significant, than that observed with fluprednylidene acetate/gentamicin/chlorohydroxyquinoline cream (75% versus 57%). The halometasone/triclosan cream was well tolerated: the incidence of unwanted effects was significantly lower (p less than 0.05) than that with fluocinolone acetonide/neomycin cream and equal to that with fluprednylidene acetate/gentamicin/chlorohydroxyquinoline cream.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001424:Bacterial Infections / Q000188:drug therapy*; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005446:Fluocinolone Acetonide / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000009:adverse effects / Q000627:therapeutic use; D010647:Phenyl Ethers / Q000008:administration & dosage*; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D014260:Triclosan / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D010647:Phenyl Ethers; D005446:Fluocinolone Acetonide; D014260:Triclosan; C016124:fluocinolone-neomycin combination; D001623:Betamethasone; D009355:Neomycin; C036518:halometasone