[Immunofluorescence studies of the human trabecular meshwork].
Accumulation of extracellular material in the trabecular meshwork is responsible for increased resistance to outflow in the human eye. By means of the indirect immunofluorescence technique the authors detected extracellular collagen type IV, fibronectin and laminin in the trabecular meshwork and the wall of Schlemm's canal of glaucoma patients and controls. Collagen type IV is the so-called "basement membrane collagen" present in the lens capsule, Bowman's and Descemet's membranes. Fibronectin is a glycoprotein with many biologic activities; it can promote cell attachment and forms complexes with collagen. Laminin was isolated in 1979 and is present in the lamina lucida of basement membranes. The increased production and pathological metabolism of these three substances might be of some importance in the pathogenesis of primary open-angle glaucoma.
D003094:Collagen / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005902:Glaucoma, Open-Angle / Q000473:pathology*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007797:Laminin; D008565:Membrane Proteins / Q000378:metabolism; D014129:Trabecular Meshwork / Q000473:pathology*
D005353:Fibronectins; D006023:Glycoproteins; D007797:Laminin; D008565:Membrane Proteins; D003094:Collagen
Immunfluoreszenzuntersuchungen des menschlichen Trabekelwerkes.