Nimesulide in the short-term treatment of inflammatory process of dental tissues: a double-blind controlled trial against oxyphenbutazone.
One hundred out-patients with inflammatory process of dental tissues due to tooth extraction, root abscess alveolitis and periodontitis, were randomly assigned, according to a double-blind design, to one of two treatment groups with nimesulide (200 mg/day) or oxyphenbutazone (400 mg/day). By means of a self-rating record, each patient rated his pain, difficulty of chewing, redness and swelling before starting, during and at the end of treatment. Nimesulide and oxyphenbutazone were both well tolerated and effective, but the improvements during the first and the second day of treatment were of greater magnitude in the nimesulide-treated patients. Nimesulide, being well tolerated, rapid acting and effective, could be considered as a drug of choice for the treatment of inflammatory process of dental tissues.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010113:Oxyphenbutazone / Q000627:therapeutic use*; D010510:Periodontal Diseases / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*
D013449:Sulfonamides; D010113:Oxyphenbutazone; C012655:nimesulide