title: Failure of the commercial human IgG immunoglobulin preparation Polyglobin to enhance combined phagocytic and serum bactericidal activity of normal blood against Serratia marcescens.
abstract: The IgG immunoglobulin preparation Polyglobin failed to enhance the combined phagocytic and serum bactericidal activity of 65 vol% of fresh defibrinated human blood from health adults against representative test strains of Serratia marcescens, despite documented O-agglutinin activity of Polyglobin against every test strain employed. It was concluded that pooled human IgG immunoglobulin, i.e. 'natural' IgG antibodies, would not be expected to exert a beneficial effect against S. marcescens in patients with sufficient residual, functional 'natural' antibodies and complement.
mesh_terms: D001770:Blood Bactericidal Activity / Q000187:drug effects*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D012706:Serratia marcescens / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G