title: Effect of hydrazide cysteine on T cells. II. Human autologous rosette forming cells belong to two subpopulations differing with respect to the sensitivity to hydrocortisone and hydrazide cysteine.
abstract: In our studies on healthy individuals and patients suffering from chronic spastic bronchitis we demonstrated that autologous rosette forming cells in peripheral non-B lymphocytes belong to two subpopulations: HC-sensitive and HC-resistant. In about 50% of individuals there exists only one subpopulation of ARFC-HC-resistant. Treatment of individuals, whose non-B lymphocytes are 100% resistant to HC, with HC, did not cause any alteration in the ability to form rosettes. On the other hand, injection of HC into the individuals whose non-B lymphocytes are partially resistant to HC causes significant reduction of the autologous rosette formation. Similar results were obtained in the in vitro studies. Hydrazide cysteine converts HC-sensitive lymphocytes into HC-resistant which do not form rosettes. The mechanism of action of HC and HD on the cells forming autologous rosettes is discussed.
mesh_terms: D001991:Bronchitis / Q000276:immunology; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004351:Drug Resistance; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: C025196:cysteine hydrazide; D003545:Cysteine; D006854:Hydrocortisone