[Spinal concentrations of amoxicillin in purulent meningitis in children].
Hundred and fifteen children suffering of purulent meningitis (S.pneumoniae: 19; H.influenzae: 44; N.meningitidis; 23; others: 29) were treated by amoxicillin 200 mg/kg/day in four intramuscular injections. Spinal taps for assay of antibiotic levels in the CSF were taken 1 or 3 or 6 hours after the injection. The levels were respectively for this samples of 6.9 -1.7-1.4 micrograms/ml during the first 48 hours of treatment and 4.4-1.7-1.9 after one week. The concentrations CSF/serum were from 5 to 9.8 per cent at the beginning of treatment.
D000658:Amoxicillin / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000382:microbiology; D013997:Time Factors
D000658:Amoxicillin
Concentrations rachidiennes de l'amoxicilline au cours des méningites purulentes de l'enfant.