title: Distribution and origins of neurotensin-containing fibers in the nucleus ventromedialis hypothalami of the rat: an experimental immunohistochemical study.
abstract: The distribution and origins of neurotensin (NT)-containing fibers in the nucleus ventromedialis hypothalami (VM) of the rat were investigated experimentally using an indirect immunofluorescence technique. A dense plexus of NT-like immunoreactive (NTI) fibers which was composed of very fine varicosities was identified in the VM. Although they were distributed throughout its entire rostrocaudal extent, the distribution was uneven. The highest density was identified in the dorsomedial part of the VM. In the central part, a less numerous but still moderate number of NTI fibers was detected in its dorsal part. But in a ventrolateral direction, they decreased in number and in the ventrolateral part only a few NTI fibers were seen. The present study demonstrated experimentally that these fibers originate from the medial nucleus of the amygdaloid complex (AM), since destruction of the AM resulted in a marked reduction of NTI fibers ipsilaterally in the VM. These findings suggest that the AM influences the VM's functions via neurotensin-like immunoreactive fibers.
mesh_terms: D000679:Amygdala / Q000033:anatomy & histology* / Q000378:metabolism; D000818:Animals; D001931:Brain Mapping; D005455:Fluorescent Antibody Technique; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology; D009496:Neurotensin / Q000378:metabolism*; D051381:Rats; D014697:Ventromedial Hypothalamic Nucleus / Q000033:anatomy & histology* / Q000378:metabolism
chemical_list: D009496:Neurotensin