Effects of dazoxiben, an inhibitor of thromboxane synthetase, on forearm vasoconstriction in response to cold stimulation, and on human blood vessel prostacyclin production.
1 In healthy male volunteers dazoxiben (UK 37248), an inhibitor of thromboxane synthetase, abolished the arterial and venous vasoconstriction produced in the forearm by cold stimulation. 2 Aspirin alone had no effect on this vasoconstriction but negated the effect of dazoxiben. 3 In vitro dazoxiben increased the production of prostacyclin by human arteries and veins. 4 By reducing the synthesis of thromboxane A2, a potent vasoconstrictor, and by increasing the synthesis of prostacyclin, a potent vasodilator, dazoxiben may have a therapeutic role in conditions associated with abnormal vasoconstriction.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology; D001808:Blood Vessels / Q000378:metabolism*; D003080:Cold Temperature; D011464:Epoprostenol / Q000096:biosynthesis*; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011453:Prostaglandins / Q000096:biosynthesis*; D012039:Regional Blood Flow / Q000187:drug effects; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D007093:Imidazoles; D011453:Prostaglandins; C029166:dazoxiben; D011464:Epoprostenol; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase; D001241:Aspirin