[Acceleration of the excretion of monomeric 239Pu-citrate from the body as effected by pentacyne encapsulated in liposomes].
Liposomes, obtained by a modified procedure involving reverse phases, contained 2-3-times more 14C-pentacyne than the multilayer Banchem;s liposomes. Efficiency of pentacyne encapsulated in liposomes was higher, as compared with a non-encapsulated preparation in studies of urinary excretion of monomeric 239Pu-citrate in rats. Liposomal pentacyne increased most effectively the rate of the radionuclide excretion from liver tissue and skeleton as compared with the action of non-encapsulated complex-forming agent; as a result of which the radionuclide was excreted from liver tissue at a 1.6-2-times and from skeleton--with the 1.4-times higher rates. The both preparations increased the 239Pu excretion with urine and feces. The liposomal pentacyne accelerated an additional excretion of the nuclide with urine.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002951:Citrates; D005243:Feces / Q000032:analysis; D007700:Kinetics; D008081:Liposomes / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D004369:Pentetic Acid / Q000494:pharmacology*; D011005:Plutonium / Q000378:metabolism*; D051381:Rats
D002951:Citrates; D008081:Liposomes; D011005:Plutonium; D004369:Pentetic Acid
Uskorenie vyvedeniia iz organizma monomernogo 239Pu-tsitrata pod deĭstviem pentatsina, inkapsulirovannogo v liposomakh.