Activation of 2-aminofluorene by cultured plant cells.
Cultured tobacco plant cells activated 2-aminofluorene to an agent mutagenic to Salmonella typhimurium strain TA98. The plant activation of 2-aminofluorene is heat-inactivated and may not involve solely cytochrome P-450. The kinetics of activation demonstrated both time- and concentration-dependent responses.
D001711:Biotransformation; D002478:Cells, Cultured; D005449:Fluorenes / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism*; D009154:Mutation; D010947:Plants, Toxic; D012486:Salmonella typhimurium / Q000187:drug effects; D014026:Nicotiana / Q000378:metabolism*
D005449:Fluorenes; D009153:Mutagens; C012177:2-aminofluorene