Fibrin and collagen deposition and fibroblasts proliferation in granuloma of murine leprosy. Comparison of two mouse strains with different immune reactions.
Comparative immunofluorescence study with murine lepromas induced in C57BL/6NJcl (immunologically high responder) and CBA/N (low responder) mouse strains revealed that fibrin formation was associated with cell-mediated immune resistance against invasive bacilli. Histochemistry on paraffin sections further elucidated fibroblast proliferation and formation of collagen fibers following fibrin deposition only in murine lepromas with positive host reactions.
D000818:Animals; D003094:Collagen / Q000032:analysis*; D005337:Fibrin / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006099:Granuloma / Q000473:pathology*; D007111:Immunity, Cellular; D051379:Mice; D008815:Mice, Inbred Strains; D009164:Mycobacterium Infections / Q000276:immunology / Q000473:pathology*; D009167:Mycobacterium lepraemurium / Q000276:immunology; D013045:Species Specificity
D005337:Fibrin; D003094:Collagen