Spontaneous versus artificial lung metastasis: discrepant effect of whole-body irradiation in NFSA2ALM and NFSA1SLM tumor systems.
In newly established NFSA2ALM and NFSA1SLM metastases systems, preirradiation of inbred host C3H/HeJ mice with 5 Gy gamma-rays suppressed spontaneous lung metastasis from im inoculated leg tumors while artificial lung metastasis by iv injection was enhanced. The results are unique in two aspects: 1) suppression of spontaneous metastasis by whole-body preirradiation and 2) discrimination of artificial and spontaneous metastasis. This is another example indicating that the results obtained from an artificial metastasis method, which has been widely used, cannot predict the behavior of tumor cells in spontaneous metastasis.
D000818:Animals; D002460:Cell Line; D005354:Fibrosarcoma / Q000556:secondary*; D006614:Hindlimb; D008175:Lung Neoplasms / Q000556:secondary*; D051379:Mice; D008809:Mice, Inbred C3H; D009362:Neoplasm Metastasis / Q000473:pathology*; D009368:Neoplasm Transplantation; D009360:Neoplastic Cells, Circulating; D011336:Probability; D014916:Whole-Body Irradiation