Glycosaminoglycans and the control of cell surface proteinase activity.
It is postulated that the metabolically variable fine structure of pericellular heparan glycosaminoglycans affects the ability of these molecules to influence cell proliferation-associated proteinase-catalysed reactions occurring at cell surfaces. Evidence suggesting the possibility of a wide repertoire of glycosaminoglycan-mediated positive and negative effects on such reactions is reviewed. It is suggested that clinical administration of compounds related chemically to heparins might usefully modulate cell proliferation-associated proteinase activity.
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002477:Cells / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002642:Chick Embryo; D010450:Endopeptidases / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D006494:Heparin Antagonists / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008970:Molecular Weight; D011480:Protease Inhibitors / Q000378:metabolism / Q000494:pharmacology; D051381:Rats
D006025:Glycosaminoglycans; D006494:Heparin Antagonists; D011480:Protease Inhibitors; D000990:Antithrombin III; D006493:Heparin; D010450:Endopeptidases