[Regulation of pyruvate transport in mitochondria by thyroid hormones].
During thyroidectomy, the stimulating action of the catalytic amounts of a thermostable fraction of rat liver and diaphragm cytoplasm on Ca2+ transport in mitochondria, which indicates the decrease of the activity of an insulin-dependent cytoplasmic regulator (IDR) in insulin target organs. Thyroidectomized rats also manifested a decrease in blood insulin and glucose concentrations. Administration of the physiological doses of thyroxine produced an increase in both blood glucose concentration and IDR activity in the liver and diaphragm of thyroidectomized rats. Experiments with measuring the kinetics of the swelling of deenergized mitochondria in isoosmotic solution of ammonium pyruvate demonstrated the inhibition of liver mitochondrial swelling in thyroidectomized rats.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D005943:Gluconeogenesis; D006023:Glycoproteins / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008110:Liver Extracts / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000378:metabolism*; D024101:Mitochondrial Proteins; D008933:Mitochondrial Swelling; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats; D013963:Thyroid Hormones / Q000502:physiology*; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology
D001786:Blood Glucose; D006023:Glycoproteins; D007328:Insulin; D008110:Liver Extracts; D024101:Mitochondrial Proteins; D011773:Pyruvates; D013963:Thyroid Hormones; C031044:insulin-dependent cytoplasmic regulator protein, rat; D013974:Thyroxine; D002118:Calcium
Reguliatsiia transporta piruvata v mitokhondriiakh tireoidnymi gormonami.