title: Human salivary eicosanoids: circadian variation.
abstract: A circadian rhythm in the concentrations of prostaglandins (PG) E2, PGF2, PGI2 (measured as 6-keto-PGF1 alpha), immunoreactive h hydroxyeicosatetraenoic acids and immunoreactive 6-sulfidopeptide containing leukotrienes in human mixed saliva was observed. The rhythm reflected changes in the absolute amounts of these compounds in saliva. Under usual sleep-wake cycles a single peak occurred during sleep with maximal levels at 5:00 AM; the amplitude of the peak varied for each product. The rhythm was sleep-dependent and a shift occurred when the sleep-wake cycles were displaced. Basal levels of these eicosanoids were maintained even without sleep.
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D015237:Dinoprost; D015232:Dinoprostone; D011464:Epoprostenol / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D011453:Prostaglandins / Q000032:analysis*; D011458:Prostaglandins E / Q000032:analysis; D011460:Prostaglandins F / Q000032:analysis; D013189:SRS-A / Q000032:analysis; D012463:Saliva / Q000032:analysis*; D012890:Sleep / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
chemical_list: D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D013189:SRS-A; D015237:Dinoprost; D011464:Epoprostenol; D015232:Dinoprostone