Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part III-2. Chronic toxicity in beagle dogs: 13-week-treatment in male dogs.
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the chronic toxicity of MOM in male Beagle dogs after once daily repeated p.o. administration of MOM, non-crystalline solid, for 13 weeks at daily dosage of 200 and 400 mg/kg. It is concluded that no toxic effects of MOM, non-crystalline solid, were shown in the present studies. Therefore, the maximum non-toxic dose is presumed to be 400 mg/kg or more in male Beagle dogs administered p.o. once daily for 13 weeks.
D000818:Animals; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000648:ultrastructure; D007933:Leucomycins / Q000633:toxicity*; D008099:Liver / Q000648:ultrastructure; D008297:Male; D015644:Miocamycin
D007933:Leucomycins; D015644:Miocamycin