Anti-insulin receptor serum mimics the developmental role of insulin in mouse mammary explants.
A number of growth factors can maintain hormonally-responsive epithelium in murine mammary explants as well as insulin, but only insulin can promote the synthesis of casein and alpha-lactalbumin, in the presence of glucocorticoid and prolactin. Anti-insulin receptor serum can elicit these effects of insulin on milk protein gene expression. The anti-serum is unique in its ability to mimic the developmental role of insulin in murine mammary epithelium.
D000818:Animals; D002364:Caseins / Q000096:biosynthesis; D046508:Culture Techniques; D005260:Female; D007106:Immune Sera / Q000494:pharmacology*; D007328:Insulin / Q000502:physiology*; D007768:Lactalbumin / Q000096:biosynthesis; D008321:Mammary Glands, Animal / Q000254:growth & development* / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D011972:Receptor, Insulin / Q000276:immunology*
D002364:Caseins; D007106:Immune Sera; D007328:Insulin; D007768:Lactalbumin; D011972:Receptor, Insulin