Three monoclonal antibodies specific for human class II antigens detect RT1B-linked polymorphisms in rat B cells.
Three monoclonal antibodies HU-11, HU-32, and HU-33, which recognize two distinct polymorphic determinants of human class II antigens, were found to cross-react with rat B cells carrying an RT1B region-associated specificity Ba-2.6. This is the first report demonstrating that xenoimmune antibodies raised against polymorphic determinants of human class II antigens are able to detect polymorphic determinants of class II antigens in a third party species.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D003429:Cross Reactions; D008040:Genetic Linkage; D006680:HLA Antigens / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D006649:Histocompatibility Antigens; C038353:histocompatibility antigens RT, rat