The influence of long-term treatment with mecillinam on fecal Escherichia coli.
The influence of long-term treatment with a low dose of pivmecillinam on the fecal flora was investigated. Before treatment Escherichia coli was detected in about 88% of 30 outpatients with chronic recurrent urinary tract infections, but after 1-2 months only about 55% had detectable E. coli in the intestinal flora. E. coli resistant to mecillinam were not selected during the therapy. A similar group of patients treated with nitrofurantoin showed neither changes in the E. coli flora nor in the resistance pattern.
D000561:Amdinocillin Pivoxil / Q000494:pharmacology / Q000627:therapeutic use*; D004926:Escherichia coli / Q000187:drug effects*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D009582:Nitrofurantoin / Q000627:therapeutic use; D010397:Penicillanic Acid / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy
D000561:Amdinocillin Pivoxil; D010397:Penicillanic Acid; D009582:Nitrofurantoin