title: Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part III-1. Chronic toxicity in rats.
abstract: Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the chronic toxicity of MOM in male and female rats (Wistar, SPF, 5-week-old) after repeated oral administration of MOM, non-crystalline solid, for 26 weeks at daily dosages of 62.5, 125, 250, 500 and 1,000 mg/kg. The lowest dosage level of 62.5 mg/kg/day was only applied for female rats. In conclusion, the maximum non-toxic dosage level of MOM, non-crystalline solid, is presumed to be 250 mg/kg in male and female rats with p.o. administered once daily for 26 weeks.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D002761:Cholangitis / Q000139:chemically induced; D005260:Female; D007684:Kidney Tubules / Q000473:pathology; D007933:Leucomycins / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000648:ultrastructure; D008297:Male; D015644:Miocamycin; D011704:Pyelonephritis / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007933:Leucomycins; D015644:Miocamycin