title: In vitro production of azide mutagenic metabolite in Arabidopsis, Drosophila and Neurospora.
abstract: The ability of Arabidopsis, Drosophila and Neurospora to convert azide to its mutagenic metabolite was investigated. Cultures of these organisms all contained significant levels of O-acetylserine sulfhydrylase activity. Extracts from each organism produced a product from O-acetylserine and azide in vitro which was mutagenic in Salmonella typhimurium TA1530.
mesh_terms: D000818:Animals; D001386:Azides / Q000378:metabolism*; D001937:Brassica / Q000378:metabolism*; D003547:Cysteine Synthase / Q000378:metabolism; D004330:Drosophila / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*; D009491:Neurospora / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000201:enzymology
chemical_list: D001386:Azides; D009153:Mutagens; D003547:Cysteine Synthase