title: [Features of insulin tolerance to glucose in primary and secondary forms of progressive muscular dystrophy].
abstract: Fifty-eight patients, aged 15 to 45 years, suffering from various forms of progressive muscular dystrophies (PMD) (13 patients with Erb-Roth's PMD, 18 with Landouzy-Dejerine's PMD, 15 with Charcot-Marie's PMD, and 1 with Kugelberg-Welander's PMD) were observed to study the initial concentration of immunoreactive insulin and its secretion over time, following a glucose load. Insulin concentration in the blood plasma was determined with the help of radioimmunoassay kits. Patterns of the insulinemic curves in primary and secondary forms of PMDs were demonstrated to be different. Primary forms of PMDs were associated with two types of reaction, namely, plane and torpid. In cases of denervation amyotrophies the character of the insulinemic curve was similar to that in control. The results of the study point to insulin metabolism disorders related to PMDs.
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002607:Charcot-Marie-Tooth Disease / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008875:Middle Aged; D009133:Muscular Atrophy / Q000378:metabolism*; D009136:Muscular Dystrophies / Q000378:metabolism*; D013577:Syndrome
chemical_list: D001786:Blood Glucose; D007328:Insulin
vernacular_title: Osobennosti tolerantnosti insulina k gliukoze pri pervichnykh i vtorichnykh formakh progressiruiushchikh myshechnykh distrofiĭ.