title: PI*LBEI and PI*JHOU: two new alpha-1-antitrypsin alleles.
abstract: Two new variants of alpha-1-antitrypsin were found in a Chinese population by isoelectric focusing in polyacrylamide gel. They have been named Lbeijing (PI*LBEI) and Jhouyao (PI*JHOU) respectively. With the samples reduced and alkylated, both the variants were anodal to M1 and cathodal to L. Omitting the alkylation step, however, the relative mobilities of L and Jhouyao were altered. Under this condition, a characteristic of Jhouyao was revealed by isoelectric focusing in immobilized pH gradient 4.4-4.9, i.e., while its band 6 became anodal to L, band 4 was still cathodal to L.
mesh_terms: D000483:Alleles; D005260:Female; D006801:Humans; D007526:Isoelectric Point; D008297:Male; D010375:Pedigree; D000515:alpha 1-Antitrypsin / Q000235:genetics* / Q000276:immunology
chemical_list: D000515:alpha 1-Antitrypsin