Scanning electron microscopy in the diagnosis of bronchogenic squamous cell and small cell anaplastic carcinoma.
The authors believe that differential diagnostic aspects between poorly-differentiated squamous cell carcinoma (PDS) and small cell anaplastic carcinoma (SCA) may be shown by scanning electron microscopy (SEM) analysis of 'thick' sections from routine paraffin-embedded tissues. In 8 'sample' cases features were demonstrated which were typical of PDS (well-defined outlines of cells, intercellular bridges) and of SCA (fairly smooth cell surface, nuclei in relief, a spongy, granular-like appearance of cytoplasm).
D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis* / Q000648:ultrastructure; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000648:ultrastructure; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000648:ultrastructure; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged