Delayed-type hypersensitivity response in mice to Treponema pallidum.
C3H/HeJ mice which had been primed with either virulent or killed T. pallidum were studied for in vivo delayed-type hypersensitivity (DTH) responses to T. pallidum following local footpad challenge. Mice sustaining a chronic infection of 5 months duration failed to develop a DTH to treponemal antigens, whereas priming by a single intravenous injection with killed organisms resulted in a significant DTH response in mice when challenged 5 days later. Treatment of mice prior to priming with a single sublethal dose of cyclophosphamide (100 mg/kg body weight) not only failed to potentiate T. pallidum-DTH, but abrogated the response observed in untreated primed animals.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000008:administration & dosage; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011817:Rabbits; D013587:Syphilis / Q000276:immunology*; D014210:Treponema pallidum / Q000276:immunology
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D003520:Cyclophosphamide