In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line.
When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of the exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D066298:In Vitro Techniques; D008114:Liver Neoplasms, Experimental / Q000469:parasitology*; D008288:Malaria / Q000469:parasitology*; D051379:Mice; D008815:Mice, Inbred Strains; D010962:Plasmodium berghei / Q000469:parasitology*