Maturation of the lymphoid system. III. Induction of selective unresponsiveness by injection of a haptenated carbohydrate into neonatal mice.
Neonatal treatment of A/J mice with DNP-Ficoll reduced or eliminated indirect anti-DNP PFC normally produced in response to adult challenge with DNP-keyhole limpet hemocyanin. The remaining direct anti-DNP PFC response was of low avidity. Spleen cells from neonatal A/J mice inhibited the in vitro but not the in vivo response of adult spleen cells to DNP-Ficoll.
D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D005362:Ficoll / Q000031:analogs & derivatives / Q000276:immunology*; D006433:Hemocyanins; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D066298:In Vitro Techniques; D008221:Lymphoid Tissue / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D011134:Polysaccharides / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000941:Antigens; C031007:DNP-Ficoll; D011134:Polysaccharides; D005362:Ficoll; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin