title: Nutritional studies on anti alpha-amylase: I) Influence on the growth rate, blood picture and biochemistry and histological parameters in rats.
abstract: Anti-alpha-amylase is a protein characterized by an antienzymatic activity in the sense that it prevents hydrolysis of the alpha--1,4 glycoside bond of starch. Such action could be exploited for reducing the caloric value of the diet. We studied the in-vivo effectiveness of large doses of anti-alpha-amylase extracted from white beans (Phaseolus vulgaris). The growth rate of rats was clearly impaired, the blood pictures and biochemistry showed modifications, and the internal organ histology revealed alterations in the liver and kidney.
mesh_terms: D000818:Animals; D001769:Blood / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006128:Growth / Q000187:drug effects*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010940:Plant Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D010940:Plant Proteins; D000516:alpha-Amylases