Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice.
Male and female mice, IOPS OF1 strain, received an i.p. injection of diazepam 1,2,4 or 8 mg/kg daily for 3 days prior to i.p. challenge with Klebsiella pneumoniae. Diazepam pretreatment increased mortality due to Klebsiella pneumoniae indicating that diazepam alters natural resistance to infection. The mechanism has not been elucidated but would appear to involve T cells and/or macrophages.
D000818:Animals; D003975:Diazepam / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects; D007710:Klebsiella Infections / Q000276:immunology*; D007711:Klebsiella pneumoniae / Q000472:pathogenicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice
D003975:Diazepam