title: [Genetic study of saccharomycete yeast sensitivity to the lethal and mutagenic action of nitrous acid. III. Relation between mitochondrial genome variability and the unstable sensitivity of yeast cells to inactivation by nitrous acid].
abstract: The sensitivity of the yeast Saccharomyces cerevisiae to nitrous acid (NA) is significantly influenced by various spontaneous mutations of the mitochondrial (mt) genome as well as by the nuclear mutation mmg 1 leading to a decrease in the spontaneous mutability of the mt genome. The mmg 1 locus and the mt genome most probably interact and this nucleo-cytoplasmic interaction plays a role in determining the NA sensitivity of yeast cells. A significant subclonal variation of the NA sensitivity has already been reported for the strains under study. Here we show this variability to decrease significantly when the cells are devoid of the mt DNA or carry the mmg 1 mutation. These data suggest a direct relation between the unstable NA sensitivity and the variability of the mt genome.
mesh_terms: D005796:Genes / Q000187:drug effects*; D014644:Genetic Variation / Q000187:drug effects*; D005838:Genotype; D008928:Mitochondria / Q000187:drug effects*; D009153:Mutagens / Q000494:pharmacology*; D009573:Nitrites / Q000494:pharmacology*; D009608:Nitrous Acid / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*
chemical_list: D009153:Mutagens; D009573:Nitrites; D009608:Nitrous Acid
vernacular_title: Geneticheskoe izuchenie chuvstvitel'nosti drozhzheĭ sakharomitsetov k letal'nomu i mutagennomu deĭstviiu azotistoĭ kisloty. Soobshchenie III. Issledovanie sviazi mezhdu izmenchivost'iu mitokhondrial'nogo genoma i nestabil'nost'iu chuvstvitel'nosti drozhzhevykh kletok k inaktivatsii azotistoĭ kislotoĭ.