title: Automated radioautographic grain counting. Correction for grain overlap.
abstract: An algorithm is described for the calculation of radioautographic cell grain count from measurements of total cell nuclear area and total grain area. This algorithm provides a statistical correction for grain overlap that is based on the solution to the occupancy problem in probability theory. This method permits the use of automated grain counting over a wide range of grain counts per cell, and extends the useful dynamic range of radioautographic grain counting to well over 200 grains/cell.
mesh_terms: D001345:Autoradiography / Q000379:methods*; D002478:Cells, Cultured; D003584:Cytological Techniques; D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D008223:Lymphoma; D011336:Probability; D012015:Reference Standards; D013223:Statistics as Topic; D013936:Thymidine / Q000378:metabolism
chemical_list: D004247:DNA; D013936:Thymidine