Glomerular tubular balance in preterm and fullterm infants.
The development of glomerular and tubular function was studied in preterm and fullterm infants of varying gestational and postnatal age. The results indicate that glomerular functional development precedes tubular functional development until the 34th postmenstrual week. After the 34th week the tubular transport capacity seems to be more vulnerable than the glomerular filtration rate in states of disease. The release of a postulated renal vasoconstriction could account for the rapid changes in renal function after birth. The purpose of such a vasoconstriction could be to protect the tubules from an overload.
D000042:Absorption; D000818:Animals; D005865:Gestational Age; D005919:Glomerular Filtration Rate; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007567:Jaundice, Neonatal / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D007678:Kidney Glomerulus / Q000254:growth & development / Q000502:physiology*; D007684:Kidney Tubules / Q000254:growth & development / Q000502:physiology*; D007687:Kidney Tubules, Proximal / Q000502:physiology; D009318:Natriuresis; D051381:Rats; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology; D014661:Vasoconstriction; D014882:Water-Electrolyte Balance; D001613:beta 2-Microglobulin / Q000378:metabolism
D001613:beta 2-Microglobulin