The influence of methylpropionic acid and pyridazinone-3 derivatives on some immunologic and hemopoietic functions.
There was studied the influence on the cell-mediated and humoral response in vivo manifested by selected methylpropionic acid and pyridazinone-3 derivatives which had been found to possess strong immunotropic effects in the in vitro screening previously. It was shown that the compounds were generally poorly tolerated by animals, and they exerted only weak suppressive effects on antibody production, the contact hypersensitivity and survival of skin grafts. This immunosuppressive activity was accompanied by a slight decrease in the number of spleen colony forming cells (CFU-s). Only limited correlation between the biological activity of the preparations and their chemical structure was found.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D003877:Dermatitis, Contact; D004137:Dinitrochlorobenzene / Q000276:immunology; D006085:Graft Survival / Q000187:drug effects; D006168:Guinea Pigs; D006384:Hemagglutination / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D051379:Mice; D011422:Propionates / Q000494:pharmacology; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000187:drug effects
D004137:Dinitrochlorobenzene; D011422:Propionates; D011724:Pyridazines