Effect of a new synthetic C-nucleoside (EDTO) on cell proliferation.
The growth of Ehrlich ascite tumour cells obtained from NMRI mice and the proliferative response of T-lymphocytes from human peripheral blood in the presence of a mitogen: phytohemagglutinin (PHA) were studied in order to see what effect 2-(alpha and beta-D-erythrophuranosyl)-6,6-dimethyl-4,5,6,7-tetrahydroindol+ ++-4-one (a new synthetic C-nucleoside) had on cell proliferation. The uptake of 3H-thymidine was used as an index of cellular growth. The results show that although this C-nucleoside did not significantly alter the growth of the tumour cells, it did significantly inhibit the proliferation of T-lymphocytes.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D006801:Humans; D066298:In Vitro Techniques; D045563:Indolequinones; D051379:Mice; D009705:Nucleosides / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism
D045563:Indolequinones; D009705:Nucleosides; D010835:Phytohemagglutinins; C042706:6,6-dimethyl-2-erythrofuranosyl-4,5,6,7-tetrahydroindol-4-one; D013936:Thymidine