Cytoplasmic inclusions and X-ray microprobe analysis in a case of prolymphocytic leukemia.
A patient with prolymphocytic leukemia is described. The peripheral blood and bone-marrow cells contained nuclear pockets, bridges, and appendices, as well as cytoplasmic inclusions that were not membrane bound or connected with the endoplasmic reticulum. X-ray microanalysis of the cells showed them to contain large amounts of phosphorus, sulfur, chlorine, and calcium, as well as a smaller amount of sodium and magnesium in comparison with control lymphocytes. When compared with lymphocytes of a patient with chronic lymphocytic leukemia (CLL), the patient's cells showed higher amounts of magnesium, sulfur, and chlorine, while the sodium content was decreased. The usefulness of electron microscopy and X-ray microanalysis in the diagnosis of this type of leukemia is discussed.
D000328:Adult; D004577:Electron Probe Microanalysis; D004602:Elements / Q000032:analysis; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007945:Leukemia, Lymphoid / Q000473:pathology*; D008297:Male; D008855:Microscopy, Electron, Scanning
D004602:Elements