Effects of mitogens on ADCC activity and Fc receptor bearing cells.
Murine spleen cells, when activated by various mitogens (Con A, PHA, LPS, BCG) or Con-A conditioned medium show altered behavior as effector cells of antibody-mediated cell cytotoxicity (ADCC) which does not correlate with the expression of Fc-receptors (FcR) at the effector cell surface.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000494:pharmacology*; D009163:Mycobacterium bovis / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D011961:Receptors, Fc / Q000276:immunology*; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology*
D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins; D011961:Receptors, Fc; D003208:Concanavalin A