title: Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part I-2. Acute toxicity in rats.
abstract: Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The object of this study was to determine the acute toxicity in male and female rats (Wistar, 5-week-old) after single i.p., s.c. and p.o. administration of MOM, non-crystalline solid, at a dose level of 5,000 mg/kg as the maximum physically applicable dose. Observations were kept for 1 week after administration. In conclusion, no animal died during an observation period for 1 week so that the LD0 values were estimated to be more than 5,000 mg/kg in all routes of administration.
mesh_terms: D000818:Animals; D005260:Female; D007928:Lethal Dose 50; D007933:Leucomycins / Q000633:toxicity*; D008168:Lung / Q000098:blood supply; D008297:Male; D015644:Miocamycin; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000139:chemically induced
chemical_list: D007933:Leucomycins; D015644:Miocamycin