title: Applications of bioreactors in medicine.
abstract: The use of immobilized enzymes, antibodies or reactive proteins was recently considered as a promising approach for detoxification purposes. The appropriate solutions of some specific problems were described and discussed. An hollow fiber haemodialyzer with a membrane surface area of 0.6 m2 was used as standard support for L-asparaginase immobilization. Hemoperfusion columns based on modified agarose beads were also manufactured for the immobilization of antiphenobarbital antibodies.
mesh_terms: D000818:Animals; D001215:Asparaginase / Q000627:therapeutic use; D001216:Asparagine / Q000097:blood; D004800:Enzymes, Immobilized / Q000627:therapeutic use; D005112:Extracorporeal Circulation / Q000295:instrumentation*; D006801:Humans; D007163:Immunosorbent Techniques / Q000295:instrumentation; D010634:Phenobarbital / Q000097:blood / Q000276:immunology; D011817:Rabbits; D006435:Renal Dialysis / Q000379:methods
chemical_list: D004800:Enzymes, Immobilized; D001216:Asparagine; D001215:Asparaginase; D010634:Phenobarbital