Chloramphenicol acetyltransferase may confer resistance to fusidic acid by sequestering the drug.
Enterobacterial chloramphenicol acetyltransferase bound fusidic acid with high affinity, but did not acetylate the drug at an experimentally detectable rate. The enzyme may therefore confer resistance to fusidic acid by sequestering the drug and thereby preventing the drug from binding to translational elongation factor G.
D000123:Acetyltransferases / Q000378:metabolism*; D015500:Chloramphenicol O-Acetyltransferase; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D005672:Fusidic Acid / Q000494:pharmacology*; D020653:Peptide Elongation Factor G; D010445:Peptide Elongation Factors / Q000378:metabolism
D020653:Peptide Elongation Factor G; D010445:Peptide Elongation Factors; D005672:Fusidic Acid; D000123:Acetyltransferases; D015500:Chloramphenicol O-Acetyltransferase