Nonketotic hyperglycemia associated with loxapine and amoxapine: case report.
A case of nonketotic hyperglycemic coma associated with the recent introduction of loxapine is presented. Drug discontinuation led to a return of normal fasting blood glucose. Later challenge with amoxapine was also associated with acute hyperglycemia. Their common metabolite, 7-OH amoxapine, is implicated.
D000657:Amoxapine / Q000009:adverse effects* / Q000378:metabolism; D001714:Bipolar Disorder / Q000188:drug therapy; D003926:Diabetic Coma / Q000139:chemically induced*; D003989:Dibenzoxazepines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000139:chemically induced*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008152:Loxapine / Q000009:adverse effects* / Q000378:metabolism; D008875:Middle Aged
D003989:Dibenzoxazepines; D007328:Insulin; D008152:Loxapine; D000657:Amoxapine