[Membrane model of the regulation of proliferation: the theory and interpretation of an experiment].
The role of cell surface physical organization in the cell cycle regulation is analyzed within the framework of the earlier proposed theory (Chernavskii et al., 1982). Two models of cell surface are considered: hard-frame fluid-mosaic model (latticemosaic) and the fluid-mosaic one. The former deals with normal cells. The existence of integral carcasse or "frame" which is formed by the essential part of cross-linked membrane components and may have at least two different conformational states is hypothesized. The second model describes membranes of tumour cells. With the latter theory any mitogen (excluding the restoration of nutrient depletion) reduces the mechanical tensile strength of the frame and stimulates the general structural rearrangement of the plasma membrane. There are only two conformational transitions during the cell cycle which serve as signals for the beginning of S and M phases. If the values of tensile strength are great enough and therefore the conformational transitions are impossible, the cells pass into the resting (prereplicative--G01, or premitotical--G02) state. Three types of experiments are interpreted in the proposed theory: a) on differences in the action of growth factors on normal and tumour cell cycle, b) on the necessary condition for mitogenicity of lectins, c) on the stimulation of proliferation by mechanical deformation of cells.
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000648:ultrastructure; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007399:Interphase; D037102:Lectins / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology; D008954:Models, Biological; D013499:Surface Properties; D013500:Surface Tension
D006133:Growth Substances; D037102:Lectins; D008934:Mitogens
Membrannaia model' reguliatsii proliferatsii: teoriia i interpretatsiia éksperimenta.