[Changes in fatty tissue sensitivity to insulin in the process of diabetes mellitus compensation using sulfanilurea derivatives].
During incubation of an isolated adipose tissue, obtained by surgical biopsy from the left inguinal region, it was shown that insulin in concentrations of 50 and 100 microU/ml does not stimulate glucose-14C inclusion into the tissue lipids in patients with decompensated diabetes mellitus in contrast to that of healthy humans. Insulin effect on the lipid synthesis is restored up to the normal level after diabetes mellitus compensation by means of sulfaniluria derivatives. It is concluded that an elevated tissue sensitivity to insulin plays an important role in the antidiabetic action of sulfanilurea derivatives.
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000328:Adult; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism*; D050356:Lipid Metabolism; D008875:Middle Aged; D013424:Sulfanilamides / Q000627:therapeutic use*; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D014508:Urea / Q000627:therapeutic use*
D007004:Hypoglycemic Agents; D007328:Insulin; D013424:Sulfanilamides; D013453:Sulfonylurea Compounds; D014508:Urea; D005947:Glucose
Izmenenie chuvstvitel'nosti zhirovoĭ tkani k insulinu v protsesse kompensatsii sakharnogo diabeta proizvodnymi sul'fanilmocheviny.