Deficiency of a kidney metalloproteinase activity in inbred mouse strains.
Kidneys from BALB/c mice contain a potent metalloendoproteinase, termed meprin, that is active against large proteins as well as small peptides. The enzyme is present in mouse strains C57BR/cdJ, C57BL/6J, BALB/cJ, A/J, DBA/IJ, CD/l, Swiss, and ICR. Three related inbred strains, CBA/J, CBA/CaJ, and C3H/He, are markedly deficient in this enzymatic activity. This is the first report of a heritable deficiency of an intracellular proteinase in mammalian tissues. Meprin deficiency appears to have arisen as an early event in the development of the C stock. Furthermore, meprin is present in the progeny of a cross between a meprin-sufficient female (C57BL/6) and a meprin-deficient male (C3H/HeN), an indication that the trait for the deficiency is recessive.
D000603:Amino Acids, Sulfur / Q000172:deficiency*; D000818:Animals; D010450:Endopeptidases / Q000172:deficiency* / Q000235:genetics; D007668:Kidney / Q000201:enzymology*; D008666:Metalloendopeptidases; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D008625:Tiopronin / Q000172:deficiency* / Q000235:genetics
D000603:Amino Acids, Sulfur; D008625:Tiopronin; D010450:Endopeptidases; D008666:Metalloendopeptidases