title: Can viral envelope glycolipids produce auto-immunity, with reference to the CNS and multiple sclerosis?
abstract: Many viruses, with lipid envelopes derived from the host cell membranes, have been implicated in the aetiology of multiple sclerosis (MS), and epidemiological studies support an infectious agent. Alternatively the disease is thought by other workers to be auto-immune in nature, and recently much attention has been focused on immunological sensitivity to glycolipids in MS patients. In this paper it is proposed that CNS demyelination could arise in susceptible individuals (HLA type) from an immune response to glycolipids, triggered by the carrier effect of one or more enveloped neurotropic viruses.
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology*; D002493:Central Nervous System Diseases / Q000276:immunology; D002642:Chick Embryo; D003429:Cross Reactions; D003711:Demyelinating Diseases / Q000276:immunology; D006017:Glycolipids / Q000276:immunology*; D008563:Membrane Lipids / Q000276:immunology*; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology*; D009422:Nervous System Diseases / Q000276:immunology; D002679:Pan troglodytes; D012672:Semliki forest virus; D014036:Togaviridae Infections / Q000276:immunology
chemical_list: D006017:Glycolipids; D008563:Membrane Lipids