The relative roles of MHC and non-MHC antigens in bone marrow transplantation in rats. Graft acceptance and antigenic expression on donor red blood cells.
In order to investigate the influence of MHC and non-MHC genes in bone marrow transplantation, various combinations of congenic and inbred strains of rats were used as donors and recipients. A standard regimen of busulfan and cyclophosphamide treatment was used to condition the recipients. The resultant survival patterns of the animals indicated that: (1) a difference across the entire RT1 (MHC) complex is sufficient for the induction of fatal graft-versus-host disease (GVHD) in 100% of the engrafted animals; and (2) the blood group antigens RT2 and RT3, which are controlled by non-MHC genes, do not cause bone marrow graft rejection or GVHD. There were sequential changes of expression in surface alloantigens on the red cells in different donor-recipient combinations without other hematologic changes in the busulfan-cyclophosphamide conditioned bone marrow chimeras.
D000208:Acute Disease; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D016026:Bone Marrow Transplantation; D005260:Female; D006085:Graft Survival; D006087:Graft vs Host Reaction; D006386:Hemagglutination Tests; D006649:Histocompatibility Antigens / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D007700:Kinetics; D008297:Male; D011828:Radiation Chimera; D051381:Rats; D011914:Rats, Inbred BN; D011920:Rats, Inbred WF
D000954:Antigens, Surface; D006649:Histocompatibility Antigens