title: Cogan's syndrome: acute vestibular and auditory dysfunction with interstitial keratitis.
abstract: Two patients with Cogan's syndrome had acute bilateral hearing loss and vestibular dysfunction. Interstitial keratitis was discovered by slit-lamp examination. Both cases responded to corticosteroid treatment. Immediate recognition of this syndrome and the institution of high-dose corticosteroid therapy should lead to resolution of the hearing loss in patients with Cogan's syndrome.
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D034381:Hearing Loss / Q000150:complications*; D006312:Hearing Loss, Bilateral / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007634:Keratitis / Q000150:complications* / Q000188:drug therapy; D007759:Labyrinth Diseases / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014722:Vestibule, Labyrinth
chemical_list: D000305:Adrenal Cortex Hormones