Polyoxin D inhibits growth of zoopathogenic fungi.
We demonstrated that polyoxin D at millimolar concentrations caused marked morphological alterations of the human pathogens Candida albicans and Cryptococcus neoformans. C. albicans incubated in the presence of this drug grew in long chains that were severely swollen. Polyoxin D inhibited the growth of C. neoformans and killed cells of both the yeast and the hyphal phase of C. albicans. These observations give the first evidence that polyoxin antibiotics can kill zoopathogenic fungi.
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D002686:Chitin / Q000096:biosynthesis; D003454:Cryptococcus / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D011741:Pyrimidine Nucleosides / Q000494:pharmacology
D000935:Antifungal Agents; D011741:Pyrimidine Nucleosides; D002686:Chitin; C002458:polyoxorim