Arylmethanol and thiosemicarbazone influence of plasmodial macromolecular synthesis and cell stability.
The influence of mefloquine and additional antimalarial drugs on (3H)adenosine uptake, macromolecular synthesis, and cell stability was determined in rodent red cells parasitized with Plasmodium berghei. High arylmethanol to cell ratios induced lysis, whereas inhibition of macromolecular synthesis occurred at lower drug/cell ratios. A 2-acetylpyridine thiosemicarbazone rapidly suppressed (3H)adenosine uptake, and also blocked macromolecular synthesis by parasitized cells.
D000241:Adenosine / Q000378:metabolism; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology* / Q000502:physiology; D046911:Macromolecular Substances; D015767:Mefloquine; D009696:Nucleic Acids / Q000096:biosynthesis*; D010616:Phenanthrenes / Q000494:pharmacology*; D010962:Plasmodium berghei / Q000187:drug effects / Q000502:physiology*; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D012156:Reticulocytes / Q000469:parasitology; D013882:Thiosemicarbazones / Q000494:pharmacology*
D000962:Antimalarials; D046911:Macromolecular Substances; D009696:Nucleic Acids; D010616:Phenanthrenes; D011804:Quinolines; D013882:Thiosemicarbazones; C012496:alpha-(2-piperidyl)-3,6-bis(trifluoromethyl)-9-phenanthrenemethanol; C035532:thiosemicarbazone H; D000241:Adenosine; D015767:Mefloquine