The effects of calciferol and its metabolites on patients with chronic renal failure. II. Calcitriol, 1 alpha-hydroxyvitamin D3, and 24,25-dihydroxyvitamin D3.
The available data with regard to the use of calcitriol, 1 alpha-hydroxyvitamin D3 (1 alpha-OH D3), and 24,25-dihydroxyvitamin D3 (24,25-[OH]2D3) in the management of chronic renal insufficiency are reviewed. Patients with mild to moderate osteitis fibrosa experience substantial improvement with either calcitriol or 1 alpha-OH D3 therapy. However, few patients experience a reversal to normal in histologic characteristics of bone. The conditions of patients with osteomalacia do not respond to either calcitriol or 1 alpha-OH D3 therapy. The bone lesion appearing in these patients is most likely a toxic effect of aluminum. The prognosis is usually poor, but the conditions of some patients may respond to administration of 24,25-(OH)2D3 together with calcitriol. Preliminary data suggest that use of chelating agents may be beneficial. In this group of patients, 24,25-(OH)2D3 administration together with calcitriol may be beneficial.
D015650:24,25-Dihydroxyvitamin D 3; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D002117:Calcitriol / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D002614:Chelating Agents / Q000008:administration & dosage; D002648:Child; D003720:Densitometry; D004100:Dihydroxycholecalciferols / Q000378:metabolism / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D006887:Hydroxycholecalciferols / Q000378:metabolism / Q000627:therapeutic use*; D006934:Hypercalcemia / Q000139:chemically induced; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism; D008274:Magnesium / Q000097:blood; D010002:Osteitis Fibrosa Cystica / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D010018:Osteomalacia / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011379:Prognosis; D011859:Radiography; D051381:Rats; D006435:Renal Dialysis
D002614:Chelating Agents; D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D010710:Phosphates; D015650:24,25-Dihydroxyvitamin D 3; D000469:Alkaline Phosphatase; D002117:Calcitriol; D008274:Magnesium; C008088:alfacalcidol