title: [Blocking of proton-activated sodium permeability of the membranes of trigeminal ganglion neurons in the rat by organic cations].
abstract: The effect of amiloride, 2- and 4-aminopyridines, tetraethylammonium, guanidine on proton-induced membrane permeability was investigated in perfused neurons from rat trigeminal ganglia. When applied externally these substances produced a rapid and reversible blocking action on the inwardly directed proton-induced current. The degree of blocking increased with hyperpolarization and with a decrease in the intracellular concentration of permeable cations. The initially linear current-voltage relationship became nonlinear. Amyloride with effective concentrations between 10(-6)-10(-4) M was the most potent blocker among the substances tested.
mesh_terms: D000584:Amiloride / Q000494:pharmacology*; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D019791:Guanidine; D006146:Guanidines / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000494:pharmacology; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*; D012668:Trigeminal Ganglion / Q000187:drug effects*; D014276:Trigeminal Nerve / Q000187:drug effects*
chemical_list: D000631:Aminopyridines; D006146:Guanidines; D011719:Pyrazines; D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium; D000584:Amiloride; D012964:Sodium; D008274:Magnesium; D019791:Guanidine; D002118:Calcium
vernacular_title: Blokirovanie proton-aktiviruemoĭ natrievoĭ pronitsaemosti membrany neĭronov trigeminal'nogo gangliia krysy organicheskimi kationami.