Adrenal epinephrine depletion after insulin-induced hypoglycaemia in young hypothyroid rats.
We studied the influence of the thyroid hormones on the development of the ability of the adrenal glands to release epinephrine after stimulation by insulin-induced hypoglycaemia in the young rat. In animals rendered hypothyroid from birth, this development is delayed as compared to control rats. Administration of thyroxin to these animals restores the ability of the adrenals to deplete epinephrine. These results may indicate an influence of the thyroid hormones on the development of the functional innervation of the adrenal medulla in the young rat.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D007037:Hypothyroidism / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D011441:Propylthiouracil; D013974:Thyroxine; D004837:Epinephrine