title: H-2-linked gene(s) influence the granulomatous reaction to viable Mycobacterium lepraemurium in the mouse.
abstract: The genetic control of the granulomatous response to viable Mycobacterium lepraemurium (MLM) was studied in C3H and C57BL/6 inbred strains, BXH recombinant inbred strains, (C3H X C57BL) F1 hybrids, and backcross mice. The results indicate that an autosomal dominant gene, or linked complex of genes, has a marked influence on the footpad reaction to viable MLM. The distribution of responders and non-responders among 12 BXH recombinant inbred strains and linkage analysis in C3H X (C3H X C57BL)F1 backcross mice indicated that the response gene(s) are linked to the H-2 complex on chromosome 17. The same gene(s) also influence host restriction of MLM multiplication and thus appear to be the first H-2-linked gene(s) influencing resistance to a bacterial infection.
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D008040:Genetic Linkage; D006099:Granuloma / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D006183:H-2 Antigens / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009164:Mycobacterium Infections / Q000150:complications / Q000235:genetics* / Q000276:immunology; D009167:Mycobacterium lepraemurium / Q000276:immunology; D013045:Species Specificity
chemical_list: D006183:H-2 Antigens