Effect of whole-body irradiation on the half-life of antipyrine and on the microsomal enzyme system of rats. Correlation between in vivo and in vitro results.
An increase in half-life of antipyrine and a decrease in the metabolic capacity of microsomes were observed in rats 4 and 6 days after the in vivo gamma-irradiation. A correlation was noted between the in vivo half-life of antipyrine and the in vitro microsomal data.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014916:Whole-Body Irradiation
D000983:Antipyrine