Mutagenic activity from nitrosation of oligoamines.
To determine structural features necessary for the production of direct mutagenic activity from oligoamine-nitrate reaction mixtures, we systematically tested a group of aliphatic amine substrates for comutagenic action with nitrite. The ability to react with nitrite and form direct-acting mutagenic derivatives was common to a reasonably well defined class of aliphatic polyamines. In general, primary-secondary diamino compounds were mutagenic in the Ames Salmonella tester system when reacted with nitrite, whereas primary and secondary amines produced no direct mutagenic activity when tested separately. In combination with teritary amino groups, primary amines were inactive; one secondary-tertiary amine was tested, and this substrate produced mutagenic activity.
D003959:Diamines / Q000378:metabolism; D009152:Mutagenicity Tests; D009573:Nitrites / Q000378:metabolism*; D009602:Nitrosamines / Q000378:metabolism / Q000494:pharmacology*; D011073:Polyamines / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D003959:Diamines; D009573:Nitrites; D009602:Nitrosamines; D011073:Polyamines