Comparison of cefamandole and cefazolin during cardiopulmonary bypass.
In a randomized comparison, concentrations of cefazolin were found to exceed those of cefamandole in serum, atrial appendage, and sternal bone in patients undergoing cardiopulmonary bypass. No postoperative infections and no antibiotic-related complications occurred in either patient group.
D000368:Aged; D002435:Cefamandole / Q000032:analysis / Q000627:therapeutic use*; D002437:Cefazolin / Q000032:analysis / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011897:Random Allocation; D013249:Sternum / Q000032:analysis; D013530:Surgical Wound Infection / Q000517:prevention & control*
D002511:Cephalosporins; D002435:Cefamandole; D002437:Cefazolin