title: Diminished bactericidal capacity for group B streptococci of neutrophils from children with chronic granulomatous disease.
abstract: The bactericidal capacity of neutrophils from healthy adults, male children with chronic granulomatous disease, and obligate heterozygote mothers for type Ic group B streptococci was assessed, using a fluorochrome microassay. Neutrophils from patients with chronic granulomatous disease had impaired bactericidal capacity for group B streptococci when compared with adults (P less than 0.01). Carriers demonstrated intermediate killing capacity.
mesh_terms: D000328:Adult; D001770:Blood Bactericidal Activity; D002648:Child; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000097:blood*; D006579:Heterozygote; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D013292:Streptococcus agalactiae / Q000254:growth & development*