[Correlation of cephalosporin C synthesis and proteolytic enzymes in a differentiating culture of Acremonium chrysogenum (Cephalosporum acremonium) mutants].
The effect of the growth conditions and composition of the nutrient medium on the synthesis of cephalosporin C, alkaline exoproteases and cell differentiation was studied in various strains of Acremonium chrysogenum. It was observed that the changes in the above processes occurred simultaneously and depended on the aeration rate, temperature, illumination level and concentrations of methionine and soybean meal. Close correlation between the synthesis of alkaline exoproteases, cephalosporin C and formation of secondary structures in the strains of A. chrysogenum was shown.
D000164:Acremonium / Q000201:enzymology* / Q000254:growth & development; D002455:Cell Division; D002511:Cephalosporins / Q000096:biosynthesis*; D003470:Culture Media / Q000378:metabolism; D020689:Exopeptidases; D008715:Methionine / Q000378:metabolism; D010447:Peptide Hydrolases / Q000096:biosynthesis / Q000378:metabolism*; D013696:Temperature; D013997:Time Factors
D002511:Cephalosporins; D003470:Culture Media; D008715:Methionine; D020689:Exopeptidases; D010447:Peptide Hydrolases
Korreliatsiia sinteza tsefalosporina C i proteoliticheskikh fermentov v differentsiruiushcheisia kul'ture mutantov Acremonium chrysogenum (Cephalosporium acremonium).