Ultrastructural studies on the thymus gland after the administration of phenylhydrazine to bank voles (Clethrionomys glareolus).
The thymus glands of wild and laboratory reared bank voles (Clethrionomys glareolus) were examined for ultrastructural changes before and after the administration of low (20 mg/kg) and high (60 mg/kg) doses of phenylhydrazine (PhZ) given intraperitoneally on days 0, 1 and 3 of a dosing regime. Erythrocytes developed in focal aggregations in the subcapsular and outer cortical zones. There was a marked depletion of the subcapsular cortex following drug treatment that was reversed with time. A large number of granulocytes were visible in the cortex after PhZ, and mast cells developed in situ.
D000818:Animals; D003411:Arvicolinae / Q000033:anatomy & histology*; D004912:Erythrocytes / Q000648:ultrastructure; D008407:Mast Cells / Q000648:ultrastructure; D008854:Microscopy, Electron; D010659:Phenylhydrazines / Q000494:pharmacology*; D013950:Thymus Gland / Q000648:ultrastructure*
D010659:Phenylhydrazines; C030299:phenylhydrazine