The effect of heparin upon fibrinopurulent peritonitis in rats.
The effect of heparin upon the clinical and pathologic course of experimentally induced peritonitis in the rat was studied. Peritonitis was induced in 40 rats by creating a closed ileal loop 4 centimeters long at a distance of 5 centimeters from the ileocecal valve. The rats were divided into two groups of 20 each. The first group served as the control group while each rat of the second group received 30 units of heparin subcutaneously per day postoperatively. Survival was drastically increased in the group receiving heparin (p = 0.001). Adhesion or abscess formation was considerably reduced in this group. The results of peritoneal cultures showed decreased incidence of Escherichia coli and clostridia in the heparin-treated group. Blood cultures also showed decreased incidence of both aerobes and anaerobes in the treated group. It is concluded from this that the administration of heparin significantly prolongs survival time of animals with peritonitis and reduces the development of adhesions and abscesses in the peritoneal cavity. This beneficial effect could be attributed to decreased fibrinogen deposits within the peritoneal cavity, thus rendering the bacteria more susceptible to cellular and noncellular clearing mechanisms.
D000038:Abscess / Q000517:prevention & control; D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control*; D003013:Clostridium / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D005337:Fibrin / Q000037:antagonists & inhibitors*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010529:Peritoneal Cavity / Q000382:microbiology; D010538:Peritonitis / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D000267:Tissue Adhesions / Q000517:prevention & control
D005337:Fibrin; D006493:Heparin