Type I diabetes of man and the BB rat: monoclonal antibody-defined T-cell abnormalities.
Both patients and BB rats with type I diabetes mellitus have demonstrated major T-cell abnormalities, the appearance of which precede the development of overt hyperglycemia. The BB rat experiences a profound T lymphocytopenia which appears to be a necessary antecedent but is not totally sufficient in itself for the development of diabetes. Meanwhile, patients exhibit an elevated percentage of circulating T cells bearing the Ia or Dr antigen. Daily prednisone administration selectively decreases Ia+ T cells, and antithymocyte globulin (ATGAM) plus prednisone has a long-lasting effect in suppressing OKT4+ T cells in patients with recent-onset type I diabetes.
D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D011241:Prednisone / Q000627:therapeutic use; D051381:Rats; D011910:Rats, Brattleboro / Q000276:immunology*; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D011241:Prednisone