Insulin concentration in aqueous humor of rabbits: effects of alloxan-diabetes and insulin treatment.
Insulin concentrations were measured in the aqueous humors of insulin-treated and untreated diabetic rabbits. The aqueous humor insulin concentration of diabetic rabbits after feeding was less than that of normal control animals. When diabetic rabbits were treated with insulin, the aqueous humor insulin concentration rose to concentrations much greater than in normal ones. The aqueous: plasma concentration ratios of both insulin and total protein for diabetic animals were greater than those for normal ones and suggest that the permeability of the blood-aqueous barrier was greater in the diabetic rabbits. Since insulin is known to be capable of influencing the metabolism of the lens, it is conceivable that abnormal insulin concentrations in aqueous humor may influence the development of cataract in diabetes.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D007328:Insulin / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D011506:Proteins / Q000378:metabolism; D011817:Rabbits
D001798:Blood Proteins; D007328:Insulin; D011506:Proteins