Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias.
In this study, both acute electrophysiologic actions of intravenously administered theophylline and clinical effects of chronic oral theophylline therapy were assessed in 10 young patients (aged 9 to 41 years) without clinically significant cardiac disease, in whom recurrent symptoms of syncope and dizziness were attributed to transient bradyarrhythmias (sinus pauses, marked sinus bradycardia or paroxysmal atrioventricular [AV] block). Intravenous theophylline infusion (serum concentration range 9.5 to 12.0 mg/liter) shortened means sinus cycle length (control 973 +/- 285 ms versus theophylline 880 +/- 226 ms, p less than 0.005) and decreased both the estimated sinoatrial conduction time (control 169 +/- 56.0 ms versus theophylline 143 +/- 55.3 ms, p less than 0.05) and the maximum corrected sinus node recovery time (control 442 +/- 251.0 ms versus theophylline 255 +/- 146.2 ms, p less than 0.05). In addition, theophylline infusion shortened the minimum atrial paced cycle length with sustained 1:1 AV conduction (control 414 +/- 86 ms versus theophylline 379 +/- 97 ms, p less than 0.05) and consistently reduced AV node functional refractory periods. Subsequent chronic oral theophylline therapy (serum levels 9 to 12 mg/liter) was tolerated in 8 patients (80%). During a follow-up of 5 to 24 months, suppression of symptoms was achieved in 6 of the 8 patients. Thus, theophylline exhibits positive chronotropic and dromotropic effects in man at serum concentrations in the usual therapeutic range (10 to 15 mg/liter). Furthermore, suppression of symptoms during follow-up suggests that theophylline treatment may be a useful therapeutic consideration in some patients with recurrent symptomatic bradyarrhythmias.
D000293:Adolescent; D000328:Adult; D001283:Atrioventricular Node / Q000187:drug effects; D001919:Bradycardia / Q000188:drug therapy* / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial / Q000379:methods; D002986:Clinical Trials as Topic; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D012008:Recurrence; D012849:Sinoatrial Node / Q000187:drug effects; D013575:Syncope / Q000188:drug therapy / Q000503:physiopathology; D013806:Theophylline / Q000008:administration & dosage / Q000627:therapeutic use*
D013806:Theophylline