Gender and propranolol-ethanol interaction.
The in vitro effect of propranolol, a beta-receptor blocking agent, on specific activity of hepatic alcohol dehydrogenase (L-ADH) and aldehyde dehydrogenase (L-ALDH) was studied in the male and in the female rat. The presence of propranolol, in the dose range of 3 x 10(-4) M to 10(-3) M concentration in the reaction mixture noncompetitively inhibited female but not male L-ADH. Conversely, significant enhancement of mitochondrial but not cytoplasmic L-ALDH occurred in the presence of propranolol, between 10(-3) M and 10(-5) M concentration, in both sexes. The alteration of hepatic ethanol and acetaldehyde metabolizing enzymes by propranolol suggest both gender difference and possible contraindication of use of this drug in alcoholic patients.
D000079:Acetaldehyde / Q000494:pharmacology; D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000187:drug effects*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D000431:Ethanol; D011433:Propranolol; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde