Neural mechanisms involved in the recovery from insulin hypoglycemia in dogs.
The contribution of the central nervous system to recovery from insulin hypoglycemia was studied in dogs. Animals with spinal transection just above the sympathetic outflow (to isolate it from encephalic influences), bilateral vagotomy or both types of lesion received an i.v. insulin injection. Also dogs in which the entire central nervous system had been inactivated by osmotic shock were submitted to this test. The results, compared to those obtained from control groups, showed that either spinal transection or severance of the vagi alone did not prevent full recovery from hypoglycemia. When both surgical procedures were combined or the entire central nervous system had been functionally destroyed normal blood glucose concentration was not regained.
D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology*; D003655:Decerebrate State / Q000503:physiopathology; D004285:Dogs; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D007328:Insulin; D008099:Liver / Q000294:innervation / Q000378:metabolism; D008297:Male; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014628:Vagotomy; D014630:Vagus Nerve / Q000503:physiopathology*
D007328:Insulin