title: Bronchodilator effects of salbutamol powder administered via Rotahaler and of terbutaline aerosol administered via Misthaler. A comparison study in children with asthma.
abstract: A study to compare the bronchodilator effect of salbutamol powder (Ventolin, 200 micrograms) administered via a Rotahaler (SR), with that of terbutaline sulphate (Bricanyl, 500 micrograms) administered via a Misthaler (TM) was carried out in 25 children with stable moderate to severe asthma. The bronchodilator effects of salbutamol powder and terbutaline sulphate were measured by means of spirometry and clinical assessment in a double-blind, randomized fashion. The children were monitored for three hours after administration of the medication on three consecutive days. The administration of salbutamol via a Rotahaler and of terbutaline sulphate via a Misthaler resulted in significant bronchodilatation as measured by peak expiratory flow rate and spirometry. There was a significant trend for SR to give greater bronchodilatation than TM at several time intervals. Over 70% (18 of 25) of the children in this study preferred the Ventolin Rotahaler to the Bricanyl Misthaler. Both SR and TM give effective bronchodilatation and, consequently, these devices should be particularly useful in younger children who have difficulty with managing standard, metered aerosols.
mesh_terms: D000293:Adolescent; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011208:Powders; D011897:Random Allocation; D012129:Respiratory Function Tests; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000336:Aerosols; D011208:Powders; D013726:Terbutaline; D000420:Albuterol