Mutagenicity study of nine monoalkyl phthalates and a dialkyl phthalate using Salmonella typhimurium and Escherichia coli.
Nine monoalkyl (C1-C8) phthalates and di-(2-ethylhexyl) phthalate (DEHP) were assayed for mutagenicity in two strains of Salmonella typhimurium (TA98 and TA100) and two strains of Escherichia coli WP2 try- (uvrA+ and uvrA-) with and without metabolic activation with S-9 mix. The procedure of Ames et al. (Mutation Res. 1975, 31, 347) was used, with minor modifications. None of the compounds tested showed any mutagenic activity, but all the monoalkyl phthalates showed some lethality towards the S. typhimurium strains, the most toxic being monoheptyl phthalate. A marginally lethal effect on the Salmonella strains was shown by DEHP, but only at the highest concentration tested (2000 micrograms/plate) and in the absence of S-9 mix.
D000818:Animals; D004051:Diethylhexyl Phthalate / Q000633:toxicity; D004926:Escherichia coli; D008297:Male; D009153:Mutagens; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012486:Salmonella typhimurium
D009153:Mutagens; D010795:Phthalic Acids; D004051:Diethylhexyl Phthalate