title: Ceftazidime as a single agent in the management of children with fever and neutropenia.
abstract: Fifty consecutive episodes of fever in neutropenic children with malignant disease or aplastic anaemia were randomized to treatment with either ceftazidime alone or a combination of azlocillin and tobramycin, pending the results of bacteriological investigation. More than 90% of organisms isolated from these episodes were sensitive to ceftazidime, which appears to be a non-toxic alternative to aminoglycosides in such circumstances.
mesh_terms: D000293:Adolescent; D000380:Agranulocytosis / Q000150:complications*; D000741:Anemia, Aplastic / Q000150:complications*; D001390:Azlocillin; D001424:Bacterial Infections / Q000188:drug therapy*; D002442:Ceftazidime; D002511:Cephalosporins / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D009369:Neoplasms / Q000150:complications*; D009503:Neutropenia / Q000150:complications*; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D011897:Random Allocation; D014031:Tobramycin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D002511:Cephalosporins; D010406:Penicillins; D002442:Ceftazidime; D001390:Azlocillin; D014031:Tobramycin