A feasibility study to determine if microbicidal activity can be measured in dexamethasone-treated macrophage cultures.
Dexamethasone action severely limits the ingestion of Saccharomyces cerevisiae in cultures of murine peritoneal macrophages. In spite of this inhibitory response, numbers of viable yeasts sufficient for microbicidal studies can be recovered shortly after their limited ingestion from lysed steroid-treated phagocytes.
D000818:Animals; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000276:immunology
D003907:Dexamethasone