IgA1 and IgA2 in circulating immune complexes and in renal deposits of Berger's and Schönlein-Henoch glomerulonephritis.
IgA subclasses in circulating immune complexes (IgA1IC), serum immunoglobulins and mesangial deposits in Berger's and Schönlein-Henoch glomerulonephritis (GN) were studied. Both IgA1IC and IgA2IC were significantly higher in Berger's and Schönlein-Henoch GN than in healthy people. In phases of clinical activity both IgAIC subclasses further increased. The IgA1/IgA2 ratio was found not to differ from controls in either groups of patients. An increase in polymeric IgA was observed in Berger's and in Schönlein-Henoch GN. Both IgA subclasses were found in mesangial deposits.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001706:Biopsy; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology*; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology*; D007070:Immunoglobulin A / Q000032:analysis* / Q000145:classification; D007668:Kidney / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A