Saccharomyces cerevisiae alpha-factor prevents formation of glycoproteins in a cells.
alpha-Factor inhibits incorporation of [14C]glucosamine into water-soluble and into SDS-extractable glycoproteins to about 90%. The incorporation into chitin is not affected and the same is true for [14C]phenylalanine incorporation into protein. The inhibition of glycoprotein synthesis is specific for a cells.
D005944:Glucosamine / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis*; D008358:Mannose / Q000378:metabolism; D000072235:Mating Factor; D010455:Peptides / Q000494:pharmacology*; D010649:Phenylalanine / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D012995:Solubility
D006023:Glycoproteins; D010455:Peptides; D010649:Phenylalanine; D000072235:Mating Factor; D005947:Glucose; D005944:Glucosamine; D008358:Mannose