The role of leukocytes in the serum acute-phase reaction accompanying inflammatory reactions.
The effects of whole-body X-irradiation with a dose of (7 Gray) were studied on the time course of systemic responses (fever, leukocytosis, serum coeruloplasmin concentration) in turpentine-induced inflammation and on the acute-phase reaction (coeruloplasmin, haptoglobin and seromucoid) produced by various stressful conditions (turpentine-abscess, immobilization, restraint conditions). Results showed that in the irradiated animals the lack of the leukocytic and febrile response to turpentine administration was accompanied by a normal coeruloplasmin response. Therefore, we have concluded to the involvement of more than one mediator in the development of systemic reactions accompanying inflammation. The leukopenia induced by whole-body irradiation could not prevent the development or reduce the magnitude of the acute-phase response in any of the models analysed. This observation appears to make doubtful the exclusive role of leukocytes in the mediation of the acute-phase reaction.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis; D007249:Inflammation / Q000097:blood*; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014916:Whole-Body Irradiation
D001798:Blood Proteins; D002570:Ceruloplasmin