title: The pharmacology and clinical use of methotrexate.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002490:Central Nervous System / Q000378:metabolism; D004351:Drug Resistance; D005492:Folic Acid / Q000378:metabolism; D005493:Folic Acid Antagonists; D005784:Gene Amplification; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D007700:Kinetics; D002955:Leucovorin / Q000008:administration & dosage; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D010017:Osteoma, Osteoid / Q000188:drug therapy; D013940:Thymidylate Synthase / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D005493:Folic Acid Antagonists; D005492:Folic Acid; D013940:Thymidylate Synthase; D002955:Leucovorin; D008727:Methotrexate