[Mathematical model of the effect of glucocorticoids on the movement and proliferation kinetics of mammalian lymphocytes].
Effect of glucocorticoids on proliferation, death and migration of T-lymphocytes was studied by mathematical methods. A model of the interaction between hormone and thymus T1-lymphocytes is proposed which imitates involution of lymphoid tissue under stress. There were constructed models of migrations of free and radioactive chromium labeled lymphocytes in lymphoid and non-lymphoid organs, blood and lymph at arbitrary concentration of glucocorticoids in the blood. Possible mechanisms of immunodepression due to increased hormone concentrations in the organism are discussed.
D000818:Animals; D001854:Bone Marrow Cells; D002455:Cell Division; D002465:Cell Movement; D005938:Glucocorticoids / Q000502:physiology*; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology; D007700:Kinetics; D051379:Mice; D009929:Organ Size; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000033:anatomy & histology
D005938:Glucocorticoids
Matematicheskoe modelirovanie vliianiia gliukokortikoidov na dvizhenie i kinetiku proliferatsii limfotsitov mlekopitaiushchego.