title: Lack of clinical efficacy of chronic oral physostigmine in Alzheimer's disease.
abstract: Ten patients with mild to severe Alzheimer's disease were treated for up to 10 months with 10 to 15 mg oral physostigmine daily or with placebo, according to a single blind, multiple crossover protocol. No clinically meaningful improvement occurred with physostigmine treatment.
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D010830:Physostigmine / Q000008:administration & dosage*
chemical_list: D010830:Physostigmine