[Modification of DNA damage in rat hepatocytes following whole-body roentgen radiation using cysteamine and 8-bromocaffeine].
Using the elastoviscosimetric method it was shown that the level of residual DNA double-strand breaks in rat hepatocytes depended on conditions of total-body X-irradiation: it increased in the presence of a sensitizer, 8-bromocaffeine and decreased in the presence of a protector, cysteamine. This correlation confirms a major role of fixed DNA double-strand breaks in the formation of a lethal effect in a cell.
D000818:Animals; D002110:Caffeine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003543:Cysteamine / Q000494:pharmacology*; D004247:DNA / Q000528:radiation effects*; D008099:Liver / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; D051381:Rats; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; C017795:xanthobine; D002110:Caffeine; D003543:Cysteamine; D004247:DNA
Modifitsiruemost' povrezhdeniĭ v DNK gepatotsitov krys posle obshchego rentgenovskogo oblucheniia s pomoshch'iu tsisteamina i 8-bromkofeina.