Evidence for the presence of a histaminergic neuron system in the rat brain: an immunohistochemical analysis.
Histamine-containing cells in rats were identified by indirect immunofluorescent histochemistry using an antibody raised against histidine decarboxylase (HDC), the enzyme forming histamine, which was purified from fetal rat liver. HDC-like immunoreactive (HDCI) structures could be detected in the brain as well as in peritoneal mast cells and basal-granulated cells in deep crypts of the gastric mucosa of rats. Numerous HDCI neurons were found in the posterior hypothalamic area and HDCI nerve fibers with a varicose appearance of fluorescence were widely distributed in various regions of the brain.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001921:Brain / Q000166:cytology / Q000502:physiology*; D005455:Fluorescent Antibody Technique; D006632:Histamine / Q000502:physiology*; D006640:Histidine Decarboxylase / Q000276:immunology; D006651:Histocytochemistry; D008297:Male; D009474:Neurons / Q000502:physiology*; D011817:Rabbits; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains
D000906:Antibodies; D006632:Histamine; D006640:Histidine Decarboxylase