Comparative evaluation of renoscintigraphic properties and plasma clearance of 99MTc-DADS (99mTc-N,N'-bis/mercaptoacetamido ethylenediamine), 99mTc-DTPA and 131I-o-hippuran.
Plasma clearance of 99mTc-N,N'-bis (1,2-mercaptoacetamido) ethylenediamine (DADS), 99mTc-DTPA and 131I-o-hippuran (OIH) was determined in rabbits from blood-concentration decay curves after single i.v. injection of the compounds. Dynamic scintigraphy was performed using the same three compounds, and "activity" curves were compared as observed over kidney ROIs. Both clearance values and renoscintigraphic curves were similar for 99mTc-DADS and 99mTc-DTPA but evidently different from those of OIH. Biliary excretion of 99mTc-DADS was also observed. It appears that, in contrast to other authors, 99mTc-DADS cannot serve as a substitute for 131I-o-hippuran.
D000818:Animals; D005029:Ethylenediamines / Q000097:blood; D007465:Iodohippuric Acid / Q000097:blood; D015609:Organotechnetium Compounds; D004369:Pentetic Acid / Q000097:blood; D011817:Rabbits; D011866:Radioisotope Renography; D013667:Technetium / Q000097:blood; D016284:Technetium Tc 99m Pentetate
D005029:Ethylenediamines; D015609:Organotechnetium Compounds; D007465:Iodohippuric Acid; D013667:Technetium; C028923:technetium Tc 99m N,N'-bis(mercaptoacetamido)ethylenediamine; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate