title: Clinical trials with canine distemper vaccines in exotic carnivores.
abstract: Two types of killed canine distemper virus (CDV) vaccine and a modified-live CDV vaccine were clinically evaluated in four species of exotic carnivores. In 16 trials in which 13 red pandas (Ailurus fulgens) were given the killed vaccine, only 1 animal had a virus-neutralization titer that exceeded 1:100. A red panda given modified-live CDV vaccine deemed safe for gray foxes and ferrets died of bacterial pneumonia 16 days later. There was no pathologic evidence of canine distemper in that panda. The same modified-live vaccine proved to be immunogenic and safe in 12 bush dogs (Speothos venaticus), 5 maned wolves (Chrysocyon brachyurus), and 3 fennec foxes (Fennecus zerda) in which virus-neutralization titers often exceeded 1:512 and persisted for several months after vaccination.
mesh_terms: D000818:Animals; D000836:Animals, Zoo / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis; D001996:Bronchopneumonia / Q000209:etiology / Q000662:veterinary; D002335:Carnivora / Q000276:immunology*; D002986:Clinical Trials as Topic; D004216:Distemper / Q000276:immunology*; D004217:Distemper Virus, Canine / Q000276:immunology*; D004285:Dogs; D005260:Female; D008297:Male; D011552:Pseudomonas Infections / Q000209:etiology / Q000662:veterinary; D014611:Vaccination / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines