title: Presence of human papillomavirus in genital tumors.
abstract: Human papillomavirus (HPV) types 16 and 18 have been identified in two different human cervical carcinomas. The viral DNAs were molecularly cloned and used as probes to screen a large number of genital tumors by Southern blot analysis. HPV-16 or HPV-18 sequences, respectively, were found in a high percentage of cervical carcinomas, but only in a small number of condylomata acuminata or flat condylomas. The majority of the latter lesions, however, contained HPV-6 or HPV-11 sequences, respectively, which in contrast were detected only rarely in carcinomas in situ or invasively growing carcinomas. A similar distribution of the different papillomaviruses was observed when cell swabs taken from the cervix were tested by in situ hybridization.
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D003218:Condylomata Acuminata / Q000382:microbiology*; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D014412:Tumor Virus Infections / Q000382:microbiology*; D002583:Uterine Cervical Neoplasms / Q000382:microbiology*; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral