Use of covalently bound cord factor analog to increase tumor immunogenicity.
Mice were immunized in vitro and in vivo against the tumor-associated antigens of a methylcholanthrene-induced tumor, using immunogen cells coupled to a cord factor analog (trehalosedihemisuccinatemonohexadecylamide). Immune activity was measured with a short-term 51Cr-release assay. The cord factor analog potentiated immunity induced by adjuvant peptide.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology; D000276:Adjuvants, Immunologic; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D003311:Cord Factors / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006017:Glycolipids / Q000276:immunology*; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012513:Sarcoma, Experimental / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D003311:Cord Factors; D006017:Glycolipids; D000119:Acetylmuramyl-Alanyl-Isoglutamine