The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers.
The uncoupling activities of clidanac and its dechlorinated derivative on oxidative phosphorylation were examined using isolated rat liver mitochondria. Clidanac was found to uncouple the oxidative phosphorylation and no difference was detected in the uncoupling potency of the two enantiomorphs. Dechlorclidanac was significantly less effective in the uncoupling activity than clidanac.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013237:Stereoisomerism; D013386:Succinates / Q000378:metabolism; D014475:Uncoupling Agents / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D007189:Indans; D007192:Indenes; D013386:Succinates; D014475:Uncoupling Agents; C059095:clidanac