Effect of tribenzylphosphate on the active phosphate transport and ATP synthesis in yeast mitochondria.
Tribenzylphosphate (TBP), a specific inhibitor of the high affinity system for Pi transport in yeast mitochondria, inhibits the active Pi transport measured by the energy-linked swelling. The dependence of the rate of oligomycin sensitive ATP synthesis as a function of the external Pi concentration shows two kinetic systems. The high affinity system, corresponds to the range of the external Pi concentration which stimulates the respiratory rate. TBP inhibits both this system and the state 4 leads to state 3 transition.
D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D001693:Biological Transport, Active / Q000187:drug effects; D008928:Mitochondria / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010710:Phosphates / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism
D009943:Organophosphorus Compounds; D010710:Phosphates; C020533:tribenzyl phosphate; D000255:Adenosine Triphosphate