title: [Does human fibrin glue improve results in tympanoplasty?].
abstract: Human fibrin tissue adhesive diminishes the rate of recurrent perforations in tympanoplastic on a statistical base (n = 1051). The postoperative air-bone gap (1000 cps) was not influenced in a substantial amount by using tissue adhesive. The reconstruction of the lateral attic wall by endogenous conchal cartilage was facilitated by the application of fibrin tissue adhesive. In animal experiments with guinea pigs ("attic" of bulla tympanica) human fibrin tissue adhesive is superior to free muscle transplants in reconstruction of the bony bulla wall. Fibrin adhesive induces scar formation, therefore a very sparing use is necessary.
mesh_terms: D000818:Animals; D004338:Drug Combinations / Q000627:therapeutic use; D005176:Factor XIII / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D006168:Guinea Pigs; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014433:Tympanoplasty / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin
vernacular_title: Verbessert Human-Fibrinkleber die Ergebnisse der Tympanoplastik?