[The diagnostic value of serum C-peptide determination].
C-peptide and insulin serum determinations were performed in 94 glucagon-stimulated diabetics and in 15 healthy persons. A minimal increase of 1.5 ng C-peptide/ml serum after glucagon injection (1 mg i.v.) was found to be a useful parameter for the differentiation of insulin dependent and non-insulin dependent diabetics. The maximal response to glucagon occurred during the first 10 minutes after the injection (blood was drawn at 2-minutes intervals). Serum insulin levels and basal C-peptide concentrations were of no value in predicting insulin-dependency. Basal C-peptide levels were significantly different from control in juvenile insulin dependent diabetics (decrease) only.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002096:C-Peptide / Q000097:blood*; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis; D005260:Female; D005934:Glucagon / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*
D002096:C-Peptide; D007328:Insulin; D010455:Peptides; D005934:Glucagon
Zur diagnostischen Bedeutung der C-Peptidbestimmung im Serum.