Arterial prostacyclin generation is decreased in patients with malignant bone tumors.
Arterial production of PGI2 was measured in patients with malignant bone tumors and compared to that in arteries from subjects with benign bone tumors and others without tumor. Arteries from all study subjects exhibited spontaneous and arachidonate-induced PGI2 release. Arterial production of PGI2 as measured by 6-keto-PGF1 alpha was in the normal range in patients with benign tumors. In contrast, arteries from patients with malignant tumors had lower PGI2 release. Deficient arterial PGI2 production in patients with malignant tumor was present both at rest and upon stimulation of blood vessels with arachidonate. Decreased PGI2 generation could relate to tumor attachment to the endothelium, penetration of the vessel walls and subsequent metastasis.
D001859:Bone Neoplasms / Q000378:metabolism*; D002812:Chondroma / Q000378:metabolism; D002813:Chondrosarcoma / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis*; D005263:Femoral Artery / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008080:Liposarcoma / Q000378:metabolism; D012516:Osteosarcoma / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*
D011453:Prostaglandins; D011464:Epoprostenol