title: Aminoacyl-tRNA synthetases in liver, spleen and small intestine of aged leukemic and aged normal mice.
abstract: The specific activities of 17 aminoacyl-tRNA synthetases in liver, lung, heart, spleen, kidney and small intestine of old female normal and leukemic (reticulum-cell sarcoma, type A) mice have been monitored. No difference appears for lung, heart and kidney; small increases with varying particular changes for liver and marked increases in spleen and small intestine of the tumor bearing mice have been found, following a similar pattern. This finding suggests a coordinated adaptation to modulation of the requirements of protein synthesis imposed by histiocytic sarcoma.
mesh_terms: D000375:Aging; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D000818:Animals; D005260:Female; D007421:Intestine, Small / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D013154:Spleen / Q000201:enzymology
chemical_list: D000604:Amino Acyl-tRNA Synthetases