Predictors of renal function in diabetic and non-diabetic renal disease.
Forty-two patients with renal disease due to diabetic nephropathy (14 patients), tubulointerstitial disease (14 patients) and glomerular disease (14 patients) underwent measurement of glomerular filtration rate (GFR) by the 51Cr-EDTA 'one-shot' method and simultaneous serum beta 2-microglobulin, serum creatinine and creatinine clearance estimation. Serum creatinine was a significantly better predictor of GFR than serum beta 2-microglobulin in patients with diabetic nephropathy, whereas both methods were equally useful predictors of GFR in non-diabetic renal disease. Serum creatinine measurement remains the best method for detecting early reduction of GFR on a serum sample.
D000328:Adult; D003404:Creatinine / Q000097:blood / Q000652:urine; D003928:Diabetic Nephropathies / Q000503:physiopathology*; D005260:Female; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000503:physiopathology; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000503:physiopathology; D011704:Pyelonephritis / Q000503:physiopathology; D001613:beta 2-Microglobulin / Q000378:metabolism
D001613:beta 2-Microglobulin; D003404:Creatinine