Toxicological evaluation of cyclosporin A.
Toxicological studies in a variety of different animal species have shown that cyclosporin A (CS-A) is a unique immunosuppressant, since it does not cause myelotoxic, teratogenic, mutagenic, or carcinogenic effects. This is undoubtedly due to the fact CS-A produces its immunosuppressive effects by a specific action on T lymphocytes rather than by a cytotoxic mechanism. The incidence of acute inflammatory lesions was also not significantly higher in treated animals than in controls. Clear-cut organ toxicity only occurred in rats and cynomolgus monkeys, where at high doses nephro- and hepatotoxicity were observed.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology; D003524:Cyclosporins / Q000008:administration & dosage / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005891:Gingivitis / Q000139:chemically induced; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012878:Skin Neoplasms / Q000139:chemically induced
D003524:Cyclosporins