title: [Effect of testosterone on ethanol oxidation during chronic alcoholism in castrated rats].
abstract: It has been shown in non-alcoholized male rats that castration significantly and appreciably raises the level of endogenous ethanol. In chronic alcoholization of castrated and non-castrated rats, the rate of ethanol elimination (REE) is noticeably increased, with testosterone producing no essential effect on the REE. In the liver, alcohol dehydrogenase activity rises insignificantly under the effect of testosterone, whereas aldehyde dehydrogenase activity declines 30--100%.
mesh_terms: D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000437:Alcoholism / Q000503:physiopathology*; D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D002369:Castration; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D013739:Testosterone / Q000502:physiology*
chemical_list: D000431:Ethanol; D013739:Testosterone; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase; D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase
vernacular_title: Vliianie testosterona na okislenie étanola pri khronicheskom alkogolizme u kastrirovannykh krys.