Effects of naloxone on endotoxin-induced changes in ponies.
The value of naloxone (1 mg/kg of body weight/hr for 4 hrs), a beta-endorphin antagonist, was assessed in the management of endotoxin-induced shock in ponies. Three groups of 5 ponies each were used: controls, ponies given Escherichia coli endotoxin put untreated, and ponies given endotoxin and then treated with naloxone. Endotoxin-induced changes in hemodynamics, blood chemical values, regional blood flow, plasma enzymes, and energy supplies were measured at selected times during the first 6 hours after endotoxin was given. There was no evidence that beta-endorphins released during shock were responsible for the hemodynamic changes, blood flow changes, plasma enzyme changes, or energy deficits, because naloxone, at this dosage level, did not prevent these endotoxin-induced changes.
D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D004731:Endotoxins / Q000009:adverse effects; D004926:Escherichia coli; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006734:Horse Diseases / Q000097:blood* / Q000188:drug therapy; D006736:Horses; D006863:Hydrogen-Ion Concentration; D008297:Male; D009270:Naloxone / Q000494:pharmacology* / Q000627:therapeutic use; D012772:Shock, Septic / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*
D004731:Endotoxins; D009270:Naloxone