title: Pancreatic islet and other autoantibodies in juvenile and adult onset diabetics in Australia.
abstract: The prevalence of serum antibodies to the cytoplasm of the pancreatic islet cell (PICA), and of thyroid microsomal (TMA), gastric parietal cell (GPCA) and anti-nuclear (ANA) antibodies was studied in 135 newly diagnosed diabetics presenting to a hospital for adults and 83 children with recent onset diabetes presenting to a children's hospital. The study also included another 144 diabetic children whose disease had been present longer, and 200 control children. There was a high prevalence (87%) of PICA in the children whose diabetes had just been diagnosed in comparison with control children (1%):(P less than .0001). Diabetic children also had a high prevalence (21%) of one or more of the other autoantibodies in comparison with the control children (9%):(P less than .001). Only 26% of the 58 insulin dependent adults had PICA but 33% had other autoantibodies. Two (3%) of the 77 adult diabetics who did not require insulin had PICA; 8% had other autoantibodies.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001315:Australia; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D003920:Diabetes Mellitus / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology; D014777:Virus Diseases / Q000150:complications
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies