Demethoxyrapamycin (AY-24,668), a new antifungal antibiotic.
Demethoxyrapamycin is a new antifungal antibiotic which is co-produced with rapamycin by Streptomyces hygroscopicus. It was isolated as a minor component during recovery of rapamycin. Its antifungal and antitumor activity is compared with that of rapamycin.
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D005285:Fermentation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011090:Polyenes / Q000302:isolation & purification / Q000494:pharmacology; D020123:Sirolimus / Q000031:analogs & derivatives; D013302:Streptomyces / Q000378:metabolism
D000935:Antifungal Agents; D011090:Polyenes; C038313:demethoxyrapamycin; D020123:Sirolimus