Anti-inflammatory and analgesic properties of four amino-acids.
Orally administered L-isoleucine, DL-isoleucine and L-leucine exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only. L-isoleucine also exhibited prolonged analgesic effect while DL-isoleucine had a short lasting effect. The amino-acids produced no gastric ulceration or overt acute toxicity in doses which effectively suppress inflammation. Anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.
D000596:Amino Acids / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D003967:Diarrhea / Q000517:prevention & control; D004487:Edema / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats
D000596:Amino Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D010653:Phenylbutazone