title: Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-10. Toxicity of metabolites of miocamycin: acute toxicity of Mb12 in mice.
abstract: We evaluated acute toxicity and estimated LD50 values of Mb12, one of the main metabolites of MOM, in male and female mice after single oral administration. Observations were continued for 1 week after treatment. The LD50 values were calculated according to Litchfield-Wilcoxon's method. It is concluded that LD50 values of Mb12 were 5,750 mg/kg (4,914.5-6,727.5 mg/kg) in male mice and 4,950 mg/kg (4,194.9-5,841.0 mg/kg) in female mice, respectively.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D007933:Leucomycins / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D051379:Mice; D015644:Miocamycin
chemical_list: D000900:Anti-Bacterial Agents; D007933:Leucomycins; D015644:Miocamycin