[Neurochemical aspects of therapeutic electric stimulation].
Comparative analysis of the CSF and blood protein-peptide composition in Parkinsonian patients performed with the aid of indwelled electrodes prior to and after therapeutic electrical stimulation (TES) of the brain subcortical structures, revealed a therapeutic effect in the form of reduced muscular rigidity and a mental activation with a positive emotional response. After the TES the protein content in the biological fluids tended to become normalized and the the range of low-molecular protein-peptide fractions changed. A high-performance liquid chromatography, bidimensional electrophoresis and thin-layer chromatography revealed about 5-6 factors of peptide nature with the molecular mass less than 5000 daltons in the CSF and blood after the TES. These factors were shown to exert a biological effect upon muscle preparation of the leech.
D001798:Blood Proteins / Q000032:analysis*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D004599:Electric Stimulation Therapy; D005917:Globus Pallidus; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000628:therapy*; D010455:Peptides / Q000097:blood / Q000134:cerebrospinal fluid; D013787:Thalamic Nuclei
D001798:Blood Proteins; D002556:Cerebrospinal Fluid Proteins; D010455:Peptides
Neĭrokhimicheskie aspekty lechebnoĭ élektricheskoĭ stimuliatsii.