Synthesis and pharmacological properties of N-arylpiperazine-N'-alkylindanes.
Ten new compounds, N-aryl substituted piperazinealkylindanes, have been synthesized. The most active one 1-(2-[4-(3-chlorophenyl)-1-piperazinyl]-ethyl)-indane (compound 9), displayed evident central serotoninolytic properties in the 5-hydroxytryptamine (5-HTP) head twitch test in mice, as well as in the tryptamine convulsions test and the quipazine-stimulated hind paw flexor reflex test in rats.
D006916:5-Hydroxytryptophan / Q000037:antagonists & inhibitors; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003913:Dextroamphetamine / Q000494:pharmacology; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007192:Indenes / Q000138:chemical synthesis*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced; D012702:Serotonin Antagonists / Q000138:chemical synthesis*; D014363:Tryptamines / Q000037:antagonists & inhibitors
D007189:Indans; D007192:Indenes; D010879:Piperazines; D012702:Serotonin Antagonists; D014363:Tryptamines; C030820:tryptamine; D012110:Reserpine; D006916:5-Hydroxytryptophan; D003913:Dextroamphetamine