title: N-trifluoroacetyl derivatives as pharmacological agents. III. Analgesic, antipyretic activities and physicochemical features of some antiinflammatory trifluoroacetanilides.
abstract: Further pharmacological (antipyretic and analgesic activities) and physicochemical (pka and relative lipophilicity) studies are reported on some trifluoroacetanilides which have preliminary revealed promising activities in the animal models of acute and chronic inflammation, in analogy with the known antiinflammatory trifluoromethanesulfonanilides.
mesh_terms: D000083:Acetanilides / Q000138:chemical synthesis* / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005461:Fluorine / Q000138:chemical synthesis / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008055:Lipids; D008297:Male; D051379:Mice; D051381:Rats; D012995:Solubility
chemical_list: D000083:Acetanilides; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008055:Lipids; D005461:Fluorine