title: Immunochemical characterization of Nocardia asteroides antigens: support for a single species concept.
abstract: Nocardia asteroides strains are highly heterogeneous. They show morphological, physiological, and immunological differences. In a previous study, we delineated seven immunotypes of N. asteroides. In the present study, we compared the culture filtrate antigens of these immunotypes by antigen-antibody crossed-immunoelectrophoresis and by rocket electrophoresis. We have also compared the antigen preparations by two-dimensional electrophoresis. While unique components constitute the major portion of the components, the results indicate that similar components are present in the culture filtrates of all strains. This finding supports the view of retaining all the immunotypes in the species Nocardia asteroides rather than designating different species such as N. farcinica and N. sebivorans.
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis*; D003429:Cross Reactions; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D008970:Molecular Weight; D009617:Nocardia Infections / Q000175:diagnosis; D009616:Nocardia asteroides / Q000276:immunology*; D012698:Serologic Tests
chemical_list: D000942:Antigens, Bacterial