The treatment of dermatophytoses of the glabrous skin: a comparison of undecylenic acid and its salt versus tolnaftate.
In a double-blind study, the efficacy of 1% tolnaftate cream, 3% undecylenic acid and its zinc salt, and a placebo cream were tested in dermatophytosis of the glaborous skin and groin. Ninety-seven subjects completed the study: 33 received tolnaftate, 23 of these subjects were cured clinically and mycologically. Thirty-two subjects received 3% undecylenic acid and 20% zinc undecylenate as a cream. Of these, 21 were cured clinically and mycologically. Only three of the 32 subjects receiving placebo were cured clinically and mycologically. Both tolnaftate and undecylenic acid and its zinc salt are effective in this condition.
D002986:Clinical Trials as Topic; D003881:Dermatomycoses / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D009824:Ointments; D014047:Tolnaftate / Q000008:administration & dosage*; D014476:Undecylenic Acids / Q000008:administration & dosage*
D009824:Ointments; D014476:Undecylenic Acids; D014047:Tolnaftate