[Virus-inhibiting properties of the carbonyl-conjugated pentaene roseofungin].
The antiinfluenza activity of roseofungin, a polyenic macrolide antibiotic was studied in vitro on surviving fragments of the chick embryo chorionallantoic membranes and in ovo on growing chick embryos. It was shown that the antibiotic activity against influenza A and B viruses was sufficiently high. The activity of roseofungin against influenza A virus did not differ from that of remantadin, the most active inhibitor of influenza virus reproduction. However, the activity of roseofungin against influenza B virus was an advantage of this antibiotic over remantadin, which had practically no effect on this virus type. A statistically significant protective effect of roseofungin (p less than 0.05) was shown on the animals with experimental influenza. The study on the antiviral activity of roseofungin against the DNA-containing variolovaccine virus revealed that it markedly inhibited the plague reduction. Roseofungin had a pronounced inhibitory effect on cell neoplastic transformation induced by the RNA-containing oncogenic virus of Rous sarcoma.
D000818:Animals; D000998:Antiviral Agents; D009980:Influenza A virus / Q000187:drug effects; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D011090:Polyenes / Q000494:pharmacology / Q000627:therapeutic use; D012299:Rimantadine / Q000627:therapeutic use; D001357:Sarcoma, Avian / Q000517:prevention & control; D012901:Variola virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D011090:Polyenes; D012299:Rimantadine; C009192:roseofungin
Virusingibiruiushchie svoĭstva karbonil-kon'iugirovannogo pentaena rozeofungina.