Effect of hydrazide cysteine on T cells. II. Human autologous rosette forming cells belong to two subpopulations differing with respect to the sensitivity to hydrocortisone and hydrazide cysteine.
In our studies on healthy individuals and patients suffering from chronic spastic bronchitis we demonstrated that autologous rosette forming cells in peripheral non-B lymphocytes belong to two subpopulations: HC-sensitive and HC-resistant. In about 50% of individuals there exists only one subpopulation of ARFC-HC-resistant. Treatment of individuals, whose non-B lymphocytes are 100% resistant to HC, with HC, did not cause any alteration in the ability to form rosettes. On the other hand, injection of HC into the individuals whose non-B lymphocytes are partially resistant to HC causes significant reduction of the autologous rosette formation. Similar results were obtained in the in vitro studies. Hydrazide cysteine converts HC-sensitive lymphocytes into HC-resistant which do not form rosettes. The mechanism of action of HC and HD on the cells forming autologous rosettes is discussed.
D001991:Bronchitis / Q000276:immunology; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004351:Drug Resistance; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
C025196:cysteine hydrazide; D003545:Cysteine; D006854:Hydrocortisone