Age-related effect of treatment by hydrocortisone upon the histological structure of endocrine pancreas and on the blood glucose in normal and diabetic young rats.
In three different age-groups (30-, 45- and 60-day-old) of normal and streptozotocin-diabetic rats the histological aspect of the endocrine pancreas and the blood glucose content were followed under basal conditions and against the background of hydrocortisone treatment (for 5 days with daily doses of 0.250 mg/100 g b.w.). It was established that in normal rats hydrocortisone affects characteristically the structure of pancreatic islets, but not glycemia homeostasis. In diabetic animals hydrocortisone aggravates the streptozotocin induced beta-cell damages of pancreatic islets and accentuates the diabetic hyperglycemia, depending on the age of individuals.
D000367:Age Factors; D000818:Animals; D001786:Blood Glucose / Q000096:biosynthesis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D006854:Hydrocortisone / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000033:anatomy & histology / Q000187:drug effects*; D051381:Rats
D001786:Blood Glucose; D006854:Hydrocortisone