Epstein-Barr virus-induced lymphoma in a cardiac transplant recipient.
A monoclonal diffuse histiocytic lymphoma developed during the course of a serologically documented primary Epstein-Barr virus infection in a 22-year-old cardiac transplant recipient taking cyclosporine and prednisone. Throat washings revealed the virus at tumor presentation, and the tumor was shown to contain Epstein-Barr nuclear antigen-positive cells and the viral genome. Prolonged inversion of the T cell helper/suppressor ratio was demonstrated. A brief course of acyclovir appeared to halt viral shedding in the throat but had no apparent effect on the tumor.
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000209:etiology*; D003524:Cyclosporins / Q000627:therapeutic use; D016027:Heart Transplantation; D004854:Herpesvirus 4, Human; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008297:Male; D011183:Postoperative Complications; D011241:Prednisone / Q000627:therapeutic use
D003524:Cyclosporins; D011241:Prednisone; D000212:Acyclovir