T cell nature of adjuvant peptide--induced antitumor cell-mediated cytotoxicity.
The direct cell-mediated antitumor cytotoxicity induced by coupling a murine methylcholanthrene-induced sarcoma with N-acetylmuramyl-L-alanyl-D-isoglutamine (adjuvant peptide) was eliminated by treatment of effector cells with anti-Thy 1.2 or anti-Lyt 2.2 monoclonal antibody and complement. Cytotoxicity was not H-2 restricted.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology*; D000818:Animals; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000276:immunology; D007111:Immunity, Cellular; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens; D000119:Acetylmuramyl-Alanyl-Isoglutamine