Antifertility effects of tetradecyl sodium sulphate in rabbits.
Acrosin and acrosomal hyaluronidase were inhibited by tetradecyl sodium sulphate (TDSS) in vitro at concentrations of less than 10(-4) M. TDSS prevented the removal in vitro of the cumulus oophorus by testicular hyaluronidase and the zona pellucida by acrosin. TDSS had a contraceptive effect in rabbits when administered intravaginally before coitus or released at levels of 1-3 micrograms/day from intrauterine silicone rubber devices.
D000176:Acrosin / Q000037:antagonists & inhibitors*; D000818:Animals; D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D005233:Fatty Alcohols / Q000494:pharmacology*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D007434:Intrauterine Devices; D008297:Male; D011480:Protease Inhibitors; D011817:Rabbits; D012981:Sodium Tetradecyl Sulfate / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects; D013084:Sperm-Ovum Interactions / Q000187:drug effects
D003271:Contraceptive Agents, Female; D003692:Delayed-Action Preparations; D005233:Fatty Alcohols; D011480:Protease Inhibitors; D006821:Hyaluronoglucosaminidase; D000176:Acrosin; D012981:Sodium Tetradecyl Sulfate