title: Clinical trial of pirprofen in arthrosis of the knee joint: a double-blind comparison with indomethacin.
abstract: Thirty-nine patients suffering from arthrosis of the knee were randomly allocated to either pirprofen 400 mg b.i.d. or indomethacin 50 mg b.i.d., the treatment being double-blind. Assessments for pain and joint stiffness were made after 2 and 4 weeks. Both treatments appeared to be equally effective and induced side-effects in a limited number of patients. Similar observations were made in those patients who continued the treatment over longer periods of time.
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007719:Knee Joint; D010666:Phenylpropionates / Q000627:therapeutic use*; D011897:Random Allocation; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; C008924:pirprofen; D007213:Indomethacin