title: Controlled clinical trials--the emergence of a paradigm.
mesh_terms: D002986:Clinical Trials as Topic / Q000639:trends*; D004358:Drug Therapy / Q000266:history*; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006805:Human Experimentation; D006801:Humans; D011897:Random Allocation; D013223:Statistics as Topic; D006113:United Kingdom; D014481:United States