Bovine collagen implant: histologic chronology in pig dermis.
The histologic fate of an injectable form of type I bovine dermal collagen (Zyderm Collagen Implant, ZCI) in the pig dermis and subcutaneous tissue has been studied. Biopsies were taken sequentially and analyzed by hematoxylin and eosin (H&E) and Weigert's stain, by birefringence, by direct immunofluorescence (using a highly specific rabbit anti-Zyderm antibody), and by electron microscopy. The implant material was found to stimulate a host response resulting in implant degradation and replacement by newly generated host collagen.
D000818:Animals; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D007279:Injections, Subcutaneous; D012867:Skin / Q000378:metabolism* / Q000648:ultrastructure; D013552:Swine
D003094:Collagen