title: [Chloroquine resistance of Plasmodium falciparum in Africa: current status and proposals for surveillance methods].
abstract: 34 case-reports of type RI resistance of P. falciparum to chloroquine published between 1975 and 1982 are reviewed. The patients were non-immune travellers infected in East Africa and in the neighbouring islands, especially Tanzania, Kenya and Madagascar. The increase in number and level of resistance might be a problem in Africa. A monitoring system of the patient and in the field is proposed and the possibilities of prevention and control are discussed.
mesh_terms: D000351:Africa, Eastern; D000962:Antimalarials / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D007630:Kenya; D008270:Madagascar; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000627:therapeutic use; D013636:Tanzania
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011739:Pyrimethamine
vernacular_title: La chloroquino-résistance de Plasmodium falciparum en Afrique: situation actuelle et propositions de méthodes de surveillance.