Bullous diseases: a 7-year survey of experience with 77 patients.
A prospective study of 77 consecutive patients with bullous diseases was done to study the pattern and natural history. Pemphigus was the commonest with 45 patients (59%) followed by pemphigoid with 21 patients (27%). Pemphigoid was more common in Indians than in other ethnic groups and its age of onset was a decade later than pemphigus. Unusual immunofluorescent findings in both diseases are discussed. Six of the 7 patients with dermatitis herpetiformis had linear IgA in the dermo-epidermal junction and the classical papillary IgA deposits were absent. Ultrastructural findings of pemphigoid and dermatitis herpetiformis confirmed earlier reports. Chronic bullous dermatoses of childhood was seen in 4 patients, all of whom had total remission within one year of onset disease.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002681:China; D003874:Dermatitis Herpetiformis / Q000453:epidemiology / Q000276:immunology; D005006:Ethnicity; D005260:Female; D006801:Humans; D007194:India; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000453:epidemiology / Q000276:immunology; D010392:Pemphigus / Q000276:immunology; D011446:Prospective Studies; D012872:Skin Diseases, Vesiculobullous / Q000453:epidemiology / Q000276:immunology*