Massive dobutamine overdose in a cardiovascular compromised patient.
A case of dobutamine overdose is presented. Due to a prescription mistake a patient with recent myocardial necrosis and acute arterial occlusion received up to 70 mcg/kg/min of dobutamine IV. This resulted in arterial hypotension, diminished vascular resistance, oliguria and signs of cutaneous and mucosal hyperemia. Interruption of the dobutamine infusion and substitution with dopamine normalised all abnormalities. The differences between the hemodynamic profiles of dobutamine and dopamine are discussed.
D001002:Anuria / Q000139:chemically induced*; D002395:Catecholamines / Q000506:poisoning*; D004280:Dobutamine / Q000494:pharmacology / Q000506:poisoning*; D004298:Dopamine / Q000494:pharmacology; D006322:Heart Aneurysm / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008508:Medication Errors; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D009846:Oliguria / Q000139:chemically induced*
D002395:Catecholamines; D004280:Dobutamine; D004298:Dopamine