Effect of insulin on human erythrocyte membrane fluidity in diabetes mellitus.
The effect of insulin in vitro on the fluidity of the human erythrocyte membrane in Type I (insulin-dependent) diabetic patients and healthy control subjects was investigated using a fluorescence technique. It was found that the addition of 10(-9) mol/l porcine insulin significantly increased fluorescent probe lateral mobility in the membrane lipid layer but did not appear to produce any conformational changes of membrane proteins.
D000328:Adult; D003920:Diabetes Mellitus / Q000097:blood*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008560:Membrane Fluidity / Q000187:drug effects*; D013050:Spectrometry, Fluorescence
D007328:Insulin