Differential blood pressure and metabolic effects of 9 alpha-fluorocortisol in man.
The blood pressure and metabolic effects of 9 alpha-fluorocortisol at 0.15 mg/day and 1.5 mg/day were examined in man. At high dose, systolic pressure and body weight rose, and plasma [K+], urinary sodium excretion and renin concentration fell. At low dose similar metabolic effects were seen but blood pressure was unchanged. 9 alpha-Fluorocortisol has 'mineralocorticoid' effects in man at a dose which does not alter blood pressure. These studies do not provide evidence of a 'hypertensinogenic' class of steroid hormone action in man.
D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D005438:Fludrocortisone / Q000494:pharmacology*; D006400:Hematocrit; D006801:Humans; D011188:Potassium / Q000378:metabolism; D012083:Renin / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D012083:Renin; D011188:Potassium; D005438:Fludrocortisone