Effect of radio-detoxified endotoxin on the liver microsomal drug metabolizing enzyme system in rats.
E. coli endotoxin (LPS) depresses the hepatic microsomal mono-oxygenase activity. Radio-detoxified LPS (TOLERIN: 60 Co irradiated endotoxin preparation) decreases this biotransforming activity to a smaller extent. Phenobarbital, an inducer of this mono-oxygenase system, failed to induce in LPS-treated animals. In radio-detoxified LPS-treated rats, phenobarbital induced the mono-oxygenase and almost fully restored the biotransformation.
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology / Q000528:radiation effects*; D004926:Escherichia coli; D005260:Female; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D004731:Endotoxins; C010797:tolerin; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D010634:Phenobarbital