Anti-receptor antibodies mimic the effect of insulin to down-regulate insulin receptors in cultured human lymphoblastoid (IM-9) cells.
Autoantibodies directed against the insulin receptor mimicked the effect of insulin to down-regulate insulin receptors in IM-9 cells. This down-regulation occurred at 37 C, but not at 15 or 22 C. As with insulin itself, antireceptor antibodies caused down-regulation by accelerating the rate of receptor degradation. Down-regulation induced by antireceptor antibody may play a role in desensitizing target cells to the effects of insulin.
D001323:Autoantibodies / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance; D008214:Lymphocytes; D011972:Receptor, Insulin / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D013696:Temperature
D001323:Autoantibodies; D007328:Insulin; D011972:Receptor, Insulin