Cord blood polymorphonuclear leukocyte chemotaxis. Differential response to formyl peptide and endotoxin-activated serum.
The chemotactic responses of cord blood polymorphonuclear leukocytes (PMN) to two different chemotactic factors, N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (F-peptide) and the endotoxin-activated serum (EAS), were compared with that obtained with adult PMN. Cord blood PMN chemotactic response to F-peptide was normal, while the response to EAS was decreased (57%). The number of receptor sites for F-peptide on the membranes of cord blood PMN was also found to be normal (120,000 receptors/cell). The differential chemotactic response of cord blood PMN may suggest a poorly developed receptor system for the EAS, in which complement-derived peptides are the major chemoattractants.
D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005312:Fetal Blood / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009504:Neutrophils / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*
D004731:Endotoxins; D009842:Oligopeptides; C021642:F-chemotactic peptide