Can the fetus regulate its calcium uptake?
To investigate the role of the fetus in vitamin D metabolism concentrations of vitamin D metabolites, 25(OH)D, 24,25(OH)2D and 1,25(OH)2D, were measured in human umbilical artery and vein. There were no differences between artery and vein in 25(OH)D and 24,25(OH)2D levels. 1,25(OH)2D concentrations were statistically significantly higher in the artery than in the vein. It has been shown in animal experiments that 1,25(OH)2D is an important factor in the maintenance of the placental calcium gradient. We suggest that the fetus actively produces 1,25(OH)2D and hence has the capacity to control its calcium influx.
D015650:24,25-Dihydroxyvitamin D 3; D015652:25-Hydroxyvitamin D 2; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000097:blood; D004872:Ergocalciferols / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D014807:Vitamin D / Q000378:metabolism*
D004100:Dihydroxycholecalciferols; D004872:Ergocalciferols; D014807:Vitamin D; D015652:25-Hydroxyvitamin D 2; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002118:Calcium