Cellular transformation by human papillomavirus DNA in vitro.
Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential.
D000818:Animals; D002277:Carcinoma / Q000382:microbiology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002472:Cell Transformation, Viral; D002999:Clone Cells; D004279:DNA, Viral / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D027383:Papillomaviridae / Q000235:genetics / Q000378:metabolism*; D014162:Transfection; D014412:Tumor Virus Infections / Q000235:genetics
D004279:DNA, Viral