title: Enhancement of rat kidney allografts using haptenated alloantigens and antihapten antibody.
abstract: The survival of semiallogeneic or fully allogeneic rat kidney allografts was prolonged in some strain combinations with immune complexes formed with hapten-conjugated alloantigens (TNP-Ag) of donor origin and a mouse monoclonal antihapten antibody (anti-TNP). Complexes were administered i.v. at the time of operation--and, in some cases, on subsequent days. Complexes using TNP-modified alloantigen in various forms--donor whole spleen lymphocytes, cellular membrane sonicate, or papain-solubilized-were all found to be effective in enhancing graft survival in specific donor-recipient combinations. Indefinite survival was obtained in some recipient groups with semiallogenic donors, and a more modest degree of enhancement was seen with fully allogeneic kidneys. The enhancing effect was shown to be donor-specific and highly dependent on the ratio of anti-TNP antibody to TNP alloantigen.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000276:immunology; D006085:Graft Survival; D006241:Haptens / Q000276:immunology*; D006801:Humans; D007519:Isoantigens / Q000276:immunology*; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D051379:Mice; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D014019:Tissue Donors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D006241:Haptens; D007519:Isoantigens