title: A new method of preparing monocored water-loaded microcapsules using interfacial polymer deposition process.
abstract: A new method was proposed to prepare monocored water-loaded microcapsules with diameters of 50 microns or larger by making use of the process of interfacial polymer deposition. A solution of ethylcellulose or polystyrene in dichloromethane was added dropwise to an O/W emulsion in which n-hexane was dispersed as fine droplets in aqueous gelatin solution. Successive evaporation of dichloromethane at 40 degrees C and n-hexane at 80 degrees C gave monocored water-loaded ethylcellulose or polystyrene microcapsules. Monocored water-loaded ethylcellulose/polystyrene composite microcapsules were similarly prepared using mixed solutions of the two polymers in dichloromethane instead of ethylcellulose or polystyrene solution. When those mixed solutions which exhibit phase separation were used, the composite microcapsules obtained had a patchwork-like structure in which polystyrene-rich islands are dispersed in the ethylcellulose-rich sea.
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives; D004339:Drug Compounding / Q000379:methods*; D004655:Emulsions; D008752:Methylene Chloride; D008855:Microscopy, Electron, Scanning; D011108:Polymers; D011137:Polystyrenes; D014867:Water
chemical_list: D004655:Emulsions; D011108:Polymers; D011137:Polystyrenes; D014867:Water; D008752:Methylene Chloride; C013517:ethyl cellulose; D002482:Cellulose