Polyclonal activation of B-lymphocytes in vivo by Salmonella typhimurium lipoprotein.
Lipoprotein prepared from the outer membrane of Salmonella typhimurium is a polyclonal activator of murine B-lymphocytes. It was shown to be mitogenic for splenic cultures, stimulating increased incorporation of [3H]thymidine into DNA. When injected intravenously into mice, the lipoprotein induced splenomegaly and polyclonal B-cell activation. The latter was evident from an increase in the number of plaque-forming cells against trinitrophenylated sheep erythrocytes. Similar results were obtained with Escherichia coli lipoprotein.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001426:Bacterial Proteins / Q000494:pharmacology*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004926:Escherichia coli / Q000032:analysis; D005260:Female; D008074:Lipoproteins / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008934:Mitogens; D012486:Salmonella typhimurium / Q000032:analysis*; D013154:Spleen / Q000166:cytology
D001426:Bacterial Proteins; D008074:Lipoproteins; D008934:Mitogens; D004247:DNA