Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin.
Klebsiella pneumoniae heat-stable enterotoxin was purified to apparent homogenicity by the same techniques used to purify Escherichia coli heat-stable enterotoxin. The two toxins had the same potency in the suckling mouse assay and showed immunological cross-reactivity in enzyme-linked immunosorbent assay, neutralization of secretory activity by specific hyperimmune antisera, and protection against active challenge in rats immunized with a vaccine containing synthetically produced E. coli heat-stable enterotoxin.
D000818:Animals; D000936:Antigen-Antibody Complex; D001681:Biological Assay; D004355:Drug Stability; D004768:Enterotoxins / Q000276:immunology* / Q000633:toxicity; D006358:Hot Temperature; D007106:Immune Sera; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D000936:Antigen-Antibody Complex; D004768:Enterotoxins; D007106:Immune Sera