New insights in the clastic binding hypothesis for opiate-receptor interactions I: Electron-transfer mechanism.
A clastic binding hypothesis for opiate-receptor interactions, in which the key step in eliciting the opiate response is an electron transfer from the opiate nitrogen to the receptor, is analyzed from a chemical point of view and is found to be chemically feasible. An extended form of this hypothesis is proposed in order to accommodate recent observations about the N-demethylation of morphines in the brain. An in vitro model system for studying the electron-transfer reactions of morphines is proposed, and the initial experiments in this system are reported.
D002251:Carbon Tetrachloride; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003640:Dealkylation; D004563:Electrochemistry; D004579:Electron Transport; D008956:Models, Chemical; D009020:Morphine / Q000378:metabolism; D009270:Naloxone / Q000378:metabolism; D010111:Oxymorphone / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism*
D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine; D010111:Oxymorphone; D002251:Carbon Tetrachloride