[Effect of enkephalinamide on the sensitivity of neurons of the lateral hypothalamus to phenamine in the rat].
The influence of opiatotropic drugs on the sensitivity of lateral hypothalamic neurons to amphetamine in the Wistar rats was studied microinotophoretically . D-met2-pro5-enkephalinamide reinforced the amphetamine reactions of most units studied and nalorphine had no effect. A suggestion is made that differences observed in the action of D-met2-pro5-enkephalinamide and nalorphine on the neuronal responses to amphetamine are due to activation of different opiate receptors.
D000200:Action Potentials / Q000187:drug effects; D000661:Amphetamine / Q000008:administration & dosage*; D000818:Animals; D004347:Drug Interactions; D004744:Enkephalin, Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects*; D008297:Male; D009269:Nalorphine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects
D011957:Receptors, Opioid; D004744:Enkephalin, Methionine; C021717:enkephalin, Met(2)-ProNH2(5)-; D000661:Amphetamine; D009269:Nalorphine
Vliianie énkefalinamida na chuvstvitel'nost' neĭronov lateral'nogo gipotalamusa krys k fenaminu.