IgA specific T-cell factor produced by a human T-T hybridoma.
A human T-T hybridoma was produced, which was a fusion product between and HGPRT-deficient T-cell line, Jurkat 3, and an OKT4+ activated peripheral blood T-cell. The hybrid expressed a receptor for IgM Fc and was negative for IgA Fc. It was shown to produce a factor capable of specifically enhancing IgA production and secretion by isolated human B-cells. The factor exerts its effect directly on B-cells and appears to be different from T-cell-replacing factors previously described.
D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation; D002460:Cell Line; D006133:Growth Substances / Q000096:biosynthesis* / Q000502:physiology; D006462:Hemolytic Plaque Technique; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007070:Immunoglobulin A / Q000096:biosynthesis*; D015847:Interleukin-4; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*
D006133:Growth Substances; D007070:Immunoglobulin A; D015847:Interleukin-4