title: Cytoplasmic modification of nuclear gene expression.
abstract: A review is presented on 1) the autonomous nature of mammalian cell cytoplasm and 2) the cytoplasmic modification of nuclear gene expression. Topics include a discussion of cytoplasmic suppression of tumorigenicity. It is proposed that alterations in DNA methylation patterns may be a possible mechanism to explain cytoplasmic modification of nuclear gene expression.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000502:physiology*; D003593:Cytoplasm / Q000502:physiology*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D008745:Methylation; D051379:Mice; D009374:Neoplasms, Experimental / Q000235:genetics; D051381:Rats
chemical_list: D004247:DNA