Is serial iodohippurate renography at the bedside reliable enough to monitor renal transplants?
Renograms were obtained immediately after transplantation and repeated every other day beginning 4 days after renal transplantation. In 31 of 32 biopsy-proved acute rejection crises a flattening of phase II (secretion phase) of the renogram occurred. Of the 32 renogram changes 7 were the only signs of rejection at the time of renography. This finding confirms our previous impression based on 116 rejection episodes (diagnosed according to clinical symptoms and response to therapy) that phase II alteration in serial renograms is a sensitive and probably specific sign of rejection. Because this simple method to monitor renal transplantation is not invasive, can be done at the bedside, and gives immediate and easily interpreted results repeated renography is recommended as the basic screening method. Renography is helpful especially in patients with acute tubular necrosis after renal transplantation. The need for more invasive diagnostic procedures, such as renal biopsy and angiography, can be shown by such renograms, although this has occurred rarely in our experience.
D000328:Adult; D002648:Child; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007465:Iodohippuric Acid; D016030:Kidney Transplantation; D007683:Kidney Tubular Necrosis, Acute / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011866:Radioisotope Renography / Q000379:methods*
D007465:Iodohippuric Acid