title: Vasoactive intestinal peptide stimulates renin secretion in vitro: evidence for a direct action of the peptide on the renal juxtaglomerular cells.
abstract: The effect of vasoactive intestinal peptide (VIP) and isoproterenol on renin release in vitro was investigated using an isolated superfused rat glomerular preparation. VIP at a dose of 10(-9)-10(-7) M significantly stimulated renin release in a dose-related manner while 10(-10) M was ineffective. These data are consistent with the hypothesis that VIP is a renin-stimulating factor and can have this effect by acting directly on the renal juxtaglomerular cells.
mesh_terms: D000818:Animals; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D007606:Juxtaglomerular Apparatus / Q000187:drug effects*; D007668:Kidney / Q000032:analysis; D008297:Male; D051381:Rats; D012083:Renin / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000032:analysis / Q000494:pharmacology*
chemical_list: D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D012083:Renin; D007545:Isoproterenol