[Activation of acid proteinase from rat brain in presence of blood serum from patients with multiple sclerosis and schizophrenia in in vitro experiments].
Distinct activation of rat brain acid proteinase was found, if blood serum from patients with some neuropsychical diseases or blood serum from the animals immunized by the patient brain tissue as well as by main protein of myelin were added into the incubation mixture; this demonstrates the labilizing effect of antibrain antibodies on lysosomes. The enzymatic activation might serve as a diagnostic test for estimation of antibrain antibodies in blood serum.
D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001921:Brain / Q000201:enzymology*; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood*; D051381:Rats; D012559:Schizophrenia / Q000097:blood*
D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases
Aktivatsiia kisloĭ proteinazy mozga krys syvorotkoĭ krovi bol'nykh rasseiannym sklerozom i shizofrenneĭ v opytakh in vitro.