The resistance of C57BL/6 mice to subcutaneous infection with Mycobacterium lepraemurium is dependent on both T cells and other cells of bone marrow origin.
Thymectomized or sham-thymectomized C57BL/6 mice were irradiated and reconstituted with either C57BL/6 bone marrow cells or bone marrow cells from H-2 matched BALB/B mice. The ability to limit organism multiplication at the site of infection in response to a moderate dose of Mycobacterium lepraemurium is shown to be T-cell mediated and not dependent on the type of bone marrow cells used for reconstitution. Dissemination of the organisms on the other hand appeared to be dependent on both T cells and cells of bone marrow origin.
D000818:Animals; D001854:Bone Marrow Cells; D005260:Female; D005533:Foot Dermatoses / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008198:Lymph Nodes / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009164:Mycobacterium Infections / Q000150:complications / Q000276:immunology*; D009167:Mycobacterium lepraemurium / Q000254:growth & development; D011828:Radiation Chimera; D013154:Spleen / Q000382:microbiology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*; D013934:Thymectomy