title: Specific IgE response toward allergenic molecules during perennial hyposensitization: a three-year prospective double-blind study.
abstract: Allergenic extracts are multicomponent systems containing a number of potentially allergenic molecules. In a 3 yr prospective double-blind study, sera from 40 patients hyposensitized with either a two-component timothy extract or a 20-component timothy extract were evaluated by means of crossed radioimmunoelectrophoresis. The patients exhibited specific IgE response toward individual allergenic molecules, and IgE with new specificities did not develop after hyposensitization. A high degree of clinical protection could generally be obtained on treatment with the 20-component timothy extract, but this was true only with the two-component timothy extract containing the allergenic molecules that matched the individual IgE response.
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D000918:Antibody Specificity; D002986:Clinical Trials as Topic; D003888:Desensitization, Immunologic; D004311:Double-Blind Method; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007073:Immunoglobulin E / Q000032:analysis* / Q000276:immunology; D006109:Poaceae; D011058:Pollen / Q000276:immunology; D011446:Prospective Studies; D011863:Radioimmunoassay; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D012621:Seasons; D013223:Statistics as Topic
chemical_list: D000485:Allergens; D007073:Immunoglobulin E