A study of glial fibrillary acidic protein (GFAP) in childhood brain tumours.
A retrospective study of 366 primary brain tumours in childhood has been carried out, GFAP was detected in juvenile astrocytoma (76/121), adult astrocytoma (34/78), malignant glioma (0/8), other astrocytic tumours (2/4) and medulloblastoma (0/101). In eight medulloblastomas scanty positive cells were seen but were regarded as reactive rather than neoplastic. The presence of GFAP was only found to be of prognostic value in adult astrocytoma, where its occurrence was associated with a more favourable outcome.
D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000032:analysis / Q000401:mortality; D001932:Brain Neoplasms / Q000032:analysis* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000032:analysis / Q000401:mortality; D005904:Glial Fibrillary Acidic Protein; D005910:Glioma / Q000032:analysis / Q000401:mortality; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007381:Intermediate Filament Proteins / Q000032:analysis* / Q000276:immunology; D008527:Medulloblastoma / Q000032:analysis / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies
D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins