title: Mechanisms of immunity to respiratory syncytial virus in cotton rats.
abstract: Active immunity and maternally transmitted passive immunity to respiratory syncytial virus (RSV) were studied in cotton rats. Animals infected with respiratory syncytial virus developed complete resistance to pulmonary reinfection, which lasted at least 18 months. Nasal resistance was of shorter duration and began to diminish in 8 months. Pulmonary resistance was transferred by parabiosis, but nasal resistance was not. Adoptive transfer studies with fractionated convalescent blood showed that serum antibody, but not circulating lymphocytes, conferred pulmonary resistance. Immune females conferred antibody to their young prenatally and postnatally, with most of the antibody being transferred via colostrum and milk. Maternally transmitted immunity was more effective in the lungs than in the nose and was transient in both organs. Foster nursing experiments showed colostrum and milk to be the most important routes of immune transfer. Although resistance in infants generally correlated with serum neutralizing antibody levels, several exceptions to this correlation suggested that immune factors other than neutralizing antibody may also play an important role in maternal passive immunity.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D003411:Arvicolinae; D005260:Female; D007110:Immunity, Active; D007112:Immunity, Maternally-Acquired; D008171:Lung Diseases / Q000209:etiology / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009668:Nose Diseases / Q000209:etiology / Q000276:immunology; D010227:Parabiosis; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D010253:Respirovirus Infections / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral