Expression of endogenous murine leukemia virus in transplantable tumor cells and DNA methylation of the viral sequences.
A cell line derived from early passage of a transplantable tumor in athymic mice that initially had been injected with human breast adenocarcinoma cells produced a substantial amount of RNA sequences related to the Kirsten murine leukemia virus. The cell line derived from later passage of transplantation of these tumors diminished viral RNA production. Expression of the viral RNA sequences in these cell lines is inversely correlated with the level of viral DNA methylation in the mouse genome.
D000230:Adenocarcinoma / Q000382:microbiology*; D000818:Animals; D001483:Base Sequence; D001943:Breast Neoplasms / Q000382:microbiology*; D002460:Cell Line; D004262:DNA Restriction Enzymes; D009052:Leukemia Virus, Murine / Q000235:genetics*; D008745:Methylation; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D014183:Transplantation, Heterologous
D012367:RNA, Viral; D004262:DNA Restriction Enzymes