Tissue inhibitors of granulocyte-macrophage (GM) colony formation.
The effect of mice tissue homogenates on the inhibition of granulocyte-macrophage colony formation in vitro was studied. The potent inhibitory activity was displayed by homogenate from liver. The lowest values were found in the kidney and heart. An interrelationship between the rate of inhibition and protein concentration in the homogenates was noted. Biological role and the type of inhibitory activity are briefly discussed.
D000818:Animals; D003115:Colony-Stimulating Factors / Q000037:antagonists & inhibitors*; D006098:Granulocytes / Q000166:cytology*; D006410:Hematopoiesis; D008074:Lipoproteins / Q000378:metabolism / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology*; D051379:Mice; D011506:Proteins; D014018:Tissue Distribution
D003115:Colony-Stimulating Factors; D008074:Lipoproteins; D011506:Proteins; C016313:colony inhibiting factor