Prostaglandins, glucose homeostasis, and diabetes mellitus.
Prostaglandins of the E series are implicated as regulators of glucose homeostasis because of their effects on glucose production and secretion of insulin and glucagon. PGE is postulated to play a role in the pathophysiology of insulin secretion in adult-onset (Type II) diabetes mellitus. Evidence supporting this hypothesis includes the demonstration that PGE inhibits glucose-induced acute insulin responses in normal humans. Moreover, drugs that inhibit synthesis of PGE improve abnormal insulin secretion in human subjects with Type II diabetes mellitus.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D011453:Prostaglandins / Q000096:biosynthesis; D011458:Prostaglandins E / Q000502:physiology*
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D001786:Blood Glucose; D007328:Insulin; D011453:Prostaglandins; D011458:Prostaglandins E; D005934:Glucagon; D001241:Aspirin