Dexamethasone suppression test and mood response to methylphenidate in primary depression.
Thirty-four patients who met Research Diagnostic Criteria for the diagnosis of major depressive disorder, primary subtype, were given the dexamethasone suppression test (DST) and a methylphenidate challenge. The two tests divided the patients along the following lines: One group did not suppress cortisol and failed to respond to methylphenidate, while the other group did suppress cortisol and had a positive mood response to methylphenidate. In an open clinical trial, the former group responded preferentially to amitriptyline and the latter group responded preferentially to imipramine.
D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D003907:Dexamethasone; D004644:Emotions / Q000187:drug effects*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D008875:Middle Aged
D000639:Amitriptyline; D008774:Methylphenidate; D003907:Dexamethasone; D007099:Imipramine; D006854:Hydrocortisone