Neonatal monosodium glutamate-induced lesions of hypothalamus increase intestinal fat absorption in adult mice.
The hypothalamic lesion induced by monosodium glutamate injection during the suckling period affected the absorption of fat from the intestine. Mice in group 1, in which the hypothalamic lesion included not only the arcuate nucleus, but also the basal preoptic area and two-thirds of the ventromedial nucleus, showed more efficient rates of fat absorption with high serum concentrations of immunoreactive insulin than the control. Mice in group 2, in which the hypothalamic lesion was confined mostly to the arcuate nucleus, also showed a significant increase in fat absorption, but elevated immunoreactive insulin was not found in the serum of these mice.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001835:Body Weight; D004435:Eating; D005971:Glutamates / Q000494:pharmacology*; D007027:Hypothalamic Diseases / Q000139:chemically induced* / Q000378:metabolism; D007328:Insulin / Q000276:immunology; D007408:Intestinal Absorption; D050356:Lipid Metabolism; D051379:Mice / Q000502:physiology*; D008813:Mice, Inbred ICR; D012970:Sodium Glutamate / Q000494:pharmacology*
D005971:Glutamates; D007328:Insulin; D012970:Sodium Glutamate