Insulin and human growth hormone in the amniotic fluid in normal pregnancy and in cases of fetal central nervous system anomalies.
Amniotic fluid samples were obtained by amniocentesis in the 17th-18th weeks of pregnancy from 36 women with normal pregnancy and 6 patients with pregnancy complicated by anencephaly and/or spina bifida. Insulin and human growth hormone levels were determined by radioimmunoassay. In normal pregnancy the mean values were: 3.39 +/- 0.54 microU/ml for insulin, and 9.32 +/- 1.03 ng/ml for human growth hormone. In pregnancy complicated by anencephaly and spina bifida low insulin values and normal growth hormone values were found.
D000653:Amniotic Fluid / Q000032:analysis*; D000757:Anencephaly / Q000503:physiopathology*; D005260:Female; D013006:Growth Hormone / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000032:analysis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011863:Radioimmunoassay; D016136:Spina Bifida Occulta / Q000503:physiopathology*
D007328:Insulin; D013006:Growth Hormone