title: [Treatment of peptic ulcer with Alcid V].
abstract: The results from Alcid V treatment are reported, carried out in the course of 20 days on 39 patients with duodenal and 20 patients with gastric ulcers. A group of 20 patients with duodenal and 10 with gastric ulcers, treated with placebo served as a control under the conditions of double-blind experiment. The pains completely abated in 84 per cent of the patients with gastric ulcer, the pyrosis in 100 per cent, eructation--in 92.3 per cent and the ulcer--in 68.42 per cent, and in the patients with duodenal ulcers--76.9 per cent, 93.10 per cent, 94.3 per cent and 40.62 per cent respectively. As regards the clinical symptoms of gastric ulcers, very good effect was obtained in 76 per cent and good effect--in 24 per cent; in the cases with duodenal ulcers--70.49 per cent and 15.38 per cent respectively. The discrepancy between the effect on the clinical symptoms and on the ulcers (the changes of the latter being endoscopically determined) between the Alcid V treated patients and the control group with placebo are statistically significant. In both groups the gastric secretion (determined by pentagastrin test) is not substantially changed as compared with the values prior to the treatment. Alcid V in the dose administered and the duration of the treatment induced no adverse effects and no essential changes in the biochemical indices; it was well tolerated and could find its application in the treatment of ulcer disease.
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D005773:Gastroscopy; D006035:Glycyrrhiza; D006801:Humans; D010418:Pentagastrin; D010437:Peptic Ulcer / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D013607:Tablets; D013997:Time Factors
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D013607:Tablets; C018981:Alcid V; D010418:Pentagastrin
vernacular_title: Lechenie na iazvenata bolest s Alcid V.