In vivo and in vitro effects of metoclopramide on aldosterone secretion in rats.
This study was designed to investigate the effects of metoclopramide, a dopamine antagonist, on in vivo and in vitro aldosterone production in the rat. In addition, we examined the effect of various levels of sodium intake on the response of plasma aldosterone to metoclopramide. Metoclopramide (2-50 mg/kg) was given by ip injection to conscious rats. Metoclopramide induced a dose-related increase in plasma aldosterone, whereas it only increased plasma renin activity at high doses (20 and 50 mg/kg). The response of plasma aldosterone to 10 mg/kg of metoclopramide in the low-sodium group was greater than that in the high-sodium group. Metoclopramide had no effect on aldosterone production in isolated zona glomerulosa cells in vitro.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D011188:Potassium / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012964:Sodium / Q000008:administration & dosage / Q000032:analysis
D000450:Aldosterone; D012964:Sodium; D012083:Renin; D008787:Metoclopramide; D011188:Potassium