[Test-systems for biomonitoring based on membrane-bound enzyme complexes. III. An assessment of the genotoxic action of industrial effluents in the Ames test-system with metabolic activation by microsomal monooxygenases].
Using the Ames mutation test system II samples of the Baikal pulp and paper effluents selected at different dates have been investigated. In 9 cases the effluent samples possessed no mutagenic activity; some samples revealed frame shift mutations, i.e. a medium mutagenic effect. In the presence of a metabolic activation system from the livers of phenobarbital-induced rats the mutagenic activity was considerably reduced.
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D007220:Industrial Waste / Q000009:adverse effects*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009152:Mutagenicity Tests / Q000379:methods*; D010105:Oxygenases / Q000378:metabolism*; D010209:Paper; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012800:Siberia
D007220:Industrial Waste; D010105:Oxygenases; D010634:Phenobarbital
Test-sistemy dlia biomonitoringa na osnove membranno-sviazannykh fermentnykh kompleksov. III. Otsenka genotokischeskogo deĭstviia promyshlennykh stokov v test-sisteme Eĭmsa s metabolicheskoĭ aktivatsieĭ mikrosomal'nymi monooksigenazami.