A murine monoclonal antibody against blood group H type-1 and -2 structures.
A murine anti-H monoclonal antibody was produced. This antibody, called sp115, is an IgM that does not agglutinate classical Bombay. Sp115 may differentiate the two categories of H-deficient phenotypes. It detects H substance in both plasma and fresh saliva. Tissue antigen is found when using this antibody. The specificity of sp115 antibody was determined by adsorption with, and elution from synthetic oligosaccharide immunoadsorbents. Sp115 does not distinguish H type-1 and H type 2-structures.
D000017:ABO Blood-Group System / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001789:Blood Group Antigens / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D005643:Fucose / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007163:Immunosorbent Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D009844:Oligosaccharides / Q000276:immunology; D012463:Saliva / Q000276:immunology
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D001789:Blood Group Antigens; D006183:H-2 Antigens; D009844:Oligosaccharides; D005643:Fucose