title: Induction of c-fos gene and protein by growth factors precedes activation of c-myc.
abstract: Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc. This suggests that c-fos induction is a primary event and the earliest known effect on gene expression by growth factors.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002472:Cell Transformation, Viral / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D009857:Oncogenes; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D003513:Cycloheximide