Experimental studies on pancreatic duct occlusion with prolamine.
The effect of the occlusion of the pancreatic duct system with prolamine (Ethibloc) has been studied in animal experiments with dogs and mini-pigs. The solution becomes solid in the duct system and becomes disintegrated again within 11 days. This time, however, is sufficient to keep a high-grade atrophy of the exocrine parenchyma. With this method one doesn't risk the provocation of an acute pancreatitis. The endocrine function of the atrophied glands is satisfactory, no animal became diabetic. The basal jugular vein insulin shows no difference to that of the control group, but nevertheless the mean whole pancreas hormone content is reduced for insulin and somatostatin, but not for glucagon.
D000818:Animals; D001786:Blood Glucose; D002908:Chronic Disease; D003973:Diatrizoate; D004285:Dogs; D004338:Drug Combinations; D004848:Epithelium / Q000473:pathology; D005227:Fatty Acids; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000473:pathology; D010182:Pancreatic Diseases / Q000188:drug therapy / Q000473:pathology; D010183:Pancreatic Ducts / Q000187:drug effects* / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy / Q000473:pathology; D011409:Propylene Glycols; D011506:Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D013552:Swine; D013556:Swine, Miniature; D015028:Zein
D001786:Blood Glucose; D004338:Drug Combinations; D005227:Fatty Acids; D007328:Insulin; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D005934:Glucagon; D015028:Zein; C020481:alcoholic prolamine solution