[AIDS, related syndromes and hemophilia: the situation in France and studies in progress].
A mail survey sent to 25 hemophilia centers in France enquiring on the occurrence of AIDS or AIDS-related disorders was done in May 1983. Of 2 388 hemophiliacs representing approximately 60% of the total expected population, no case of AIDS was found. Four patients had lymphodenopathies. A relatively high frequency of lymphopenia (8%) and hyper gammaglobulinemia (21%) was found. Only 37 patients were tested for T-lymphocyte populations, 14 of whom had a T4/T8 ratio below 1. A state funded multicenter prospective study has been designed in order to evaluate the relationship between the type (domestic or imported factor VIII or IX concentrate), the dose of blood product and various clinical, immunological and virological parameters related to AIDS. Approximately 400 hemophiliacs will enter the study together with a small population of patients with thalassemia receiving packed red cells.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology; D005602:France; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications*; D011446:Prospective Studies; D013601:T-Lymphocytes / Q000032:analysis; D013789:Thalassemia / Q000150:complications
SIDA, syndromes apparentés et hémophilie: situation en France et études en cours.