Fructose-1,6-biphosphatase activity in the intestinal mucosa of developing rats.
Fructose-biphosphatase (EC 3.1.3.11) activity was determined in the proximal and distal parts of the small intestinal mucosa of rats 1-30 days of age. Activity was found to increase to a maximum on about the 10th postnatal day and then to decrease. It was always higher in the proximal than in the distal portion of the gut. The enzyme showed a wide range of pH optimum around 7.0 and was inhibited by AMP. In 10-day-old rats activity determined 24 or 48 h after a single injection of cortisone or triiodothyronine was significantly decreased. This effect was no longer found for cortisone in 14-day-old animals. Weaning 18-day-old rats to a high-fat diet for 5 or 7 days delayed but did not prevent the usual decrease in activity seen at weaning.
D000828:Animal Population Groups / Q000378:metabolism*; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D003348:Cortisone / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D005260:Female; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology*; D008297:Male; D051381:Rats / Q000254:growth & development / Q000378:metabolism*; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014284:Triiodothyronine / Q000494:pharmacology
D004041:Dietary Fats; D014284:Triiodothyronine; D006597:Fructose-Bisphosphatase; D003348:Cortisone