In vitro production of azide mutagenic metabolite in Arabidopsis, Drosophila and Neurospora.
The ability of Arabidopsis, Drosophila and Neurospora to convert azide to its mutagenic metabolite was investigated. Cultures of these organisms all contained significant levels of O-acetylserine sulfhydrylase activity. Extracts from each organism produced a product from O-acetylserine and azide in vitro which was mutagenic in Salmonella typhimurium TA1530.
D000818:Animals; D001386:Azides / Q000378:metabolism*; D001937:Brassica / Q000378:metabolism*; D003547:Cysteine Synthase / Q000378:metabolism; D004330:Drosophila / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*; D009491:Neurospora / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000201:enzymology
D001386:Azides; D009153:Mutagens; D003547:Cysteine Synthase