Left ventricular function, haemodynamics and certain indicators of neurohumoral control during submaximal exercise in patients with essential hypertension.
The study was carried out in 22 men with essential hypertension, stage I B-II B, aged 25 to 46 years, and in 10 healthy volunteers of the same age. The authors investigated indicators of systemic and intracardiac haemodynamics by echocardiography, determined the blood plasma catecholamine concentration, catecholamine excretion, renin and cyclic nucleotides activity in plasma, both at rest and during continuous submaximal graded exercise on a bicycle ergometer. The haemodynamic response to exercise differed in patients with stable HPT from healthy subjects and patients with labile HPT by an increase in diastolic blood pressure, a lesser drop in end-systolic volume and in total peripheral vascular resistance, a lesser rise in cardiac output, and by a substantially higher left ventricular mass. The left ventricular ejection fraction did not rise in patients with stable hypertension. In these patients, no statistically significant concentration of urine catecholamines and their urine excretion was observed, in contrast to the other two groups where these indicators were increased. A negative correlation was found between the left ventricular mass and the ejection fraction during exercise, which attests to a negative influence of left ventricular hypertrophy on the pump function of the heart during exercise in patients with essential hypertension.
D000328:Adult; D002395:Catecholamines / Q000378:metabolism*; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D005082:Physical Exertion; D012083:Renin / Q000378:metabolism; D013318:Stroke Volume
D002395:Catecholamines; D009712:Nucleotides, Cyclic; D012083:Renin