Mitomycin-associated renal failure. Case report and review.
Renal failure due to mitomycin chemotherapy is a poorly appreciated entity often associated with microangiopathic hemolytic anemia. We describe a 45-year-old man in whom renal failure and anemia developed, without evidence of hemolysis, five months after beginning chemotherapy with mitomycin, fluorouracil, and doxorubicin hydrochloride. A biopsy specimen taken from the patient's kidney showed fibrin thrombi in two of 18 glomeruli and in several small arteries. The patient's condition required institution of maintenance dialysis. Similar reports from the literature are reviewed.
D000230:Adenocarcinoma / Q000188:drug therapy; D001485:Basement Membrane / Q000473:pathology / Q000648:ultrastructure; D003404:Creatinine / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced*; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008937:Mitomycins / Q000009:adverse effects*; D009336:Necrosis; D011471:Prostatic Neoplasms / Q000188:drug therapy; D006435:Renal Dialysis
D008937:Mitomycins; D003404:Creatinine