Combined treatment with minoxidil and captopril in refractory hypertension.
The BP of four patients with severe hypertension could not be controlled by treatment with a variety of drugs including minoxidil and captopril. Satisfactory responses were obtained only when minoxidil and captopril were given in combination (along with diuretic and beta-adrenergic blocking agents). The doses of minoxidil could be reduced by the addition of captopril and adverse effects were thus minimized. The state of the renin-angiotensin system prior to therapy was not a reliable predictor of the hypotensive response of the combination.
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure; D002216:Captopril / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D006974:Hypertension, Malignant / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000008:administration & dosage*; D011336:Probability; D011392:Proline / Q000031:analogs & derivatives*; D011743:Pyrimidines / Q000008:administration & dosage*; D012084:Renin-Angiotensin System / Q000187:drug effects
D000959:Antihypertensive Agents; D011743:Pyrimidines; D008914:Minoxidil; D011392:Proline; D002216:Captopril