131I uptake in human thyroid after antidote treatment for mixed fission products contamination.
The efficacy of a mixed antidote treatment in blocking 131I uptake in humans was investigated in two volunteers. Simultaneous oral administration of 10 g of calcium alginate, 3 g of ferrihexacyanoferrate (II) and 130 mg of potassium iodide 30 min before 131I administration caused an almost complete block of the 131I thyroid uptake in both subjects. This indicated that calcium alginate and ferrihexacyanoferrate (II) had no influence on the blocking effect of potassium iodide on 131I thyroid uptake. This finding is important because mixed antidote treatment is the recommended treatment in cases of accidental exposure to mixed fission products.
D000328:Adult; D000464:Alginates / Q000008:administration & dosage; D001692:Biological Transport; D004359:Drug Therapy, Combination; D005260:Female; D005295:Ferrocyanides / Q000008:administration & dosage; D006801:Humans; D007455:Iodine / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D011193:Potassium Iodide / Q000008:administration & dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D013961:Thyroid Gland / Q000378:metabolism*
D000464:Alginates; D005295:Ferrocyanides; D007457:Iodine Radioisotopes; D011837:Radiation-Protective Agents; D011193:Potassium Iodide; D007455:Iodine; C000170:ferric ferrocyanide