[Changes in the components of the animal fibrinolytic system induced by the action of physiological activators and enzymes of fungal origin].
The rat fibrinolytic system components by means of intravenous injection of physiological activators (tissue plasminogen activator, urokinase) and of enzymes isolated from the Fungi imeprfecti cultures (tricholysin, longolytin) have been investigated. It has been demonstrated that the tissue plasminogen activator and urokinase exert a similar effect on fibrinolysis by inducing a short-term increase of the euglobulin fraction fibrinolytic activity but do not practically change other components of the fibrinolytic system including the antiplasmin content. Tricholysin and longolytin produce a stronger action on the fibrinolytic system by significant affecting almost all the parameters, especially the antiplasmin content. The results obtained show that physiological activators as compared with fungal enzymes possess with better thrombolytic properties.
D000818:Animals; D010450:Endopeptidases / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D003904:Mitosporic Fungi / Q000201:enzymology; D010447:Peptide Hydrolases / Q000494:pharmacology*; D010960:Plasminogen Activators / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
D005343:Fibrinolytic Agents; D010450:Endopeptidases; D010447:Peptide Hydrolases; C037962:longolytin; C014864:tricholysine; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator
Izmeneniia komponentov fibrinoliticheskoĭ sistemy zhivotnykh pri deĭstvii fiziologicheskikh aktivartorov i fermentov gribnogo proiskhozhdeniia.