Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance.
Serotonin and LSD hyperpolarized serotonergic dorsal raphe neurons in rat midbrain slices; the hyperpolarizations were accompanied by a decrease in input resistance, suggesting an increase in potassium conductance as one possible mechanism. Reversal potentials for serotonin and LSD-induced hyperpolarizations showed a shift of approximately 18 mV for a two-fold change in extracellular potassium concentration; this shift was close to that predicted by the Nernst equation for a potassium-dependent conductance.
D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects*; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D011903:Raphe Nuclei / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology; D009435:Synaptic Transmission
D007473:Ion Channels; D012701:Serotonin; D008238:Lysergic Acid Diethylamide; D011188:Potassium