Monoclonal gammopathy in adult T-cell leukemia/lymphoma: a report of three cases.
Adult T-cell leukemia/lymphoma (ATL/L) is clustered in southwestern Japan, especially in the Nagasaki and Kagoshima areas. It was shown that this clustering correlated with the presence of antibodies to antigens of a new C-type RNA leukemia virus. Surface marker analysis of neoplastic T-cells of ATL/L patients shows the helper/inducer phenotype (Leu-1+, Leu-2a- and Leu-3a+). On the other hand, the association between T-cell malignancy including ATL/L and monoclonal gammopathy is very rare. Three unique cases of ATL/L with monoclonal gammopathy are reported. Yet the meaning of an M-component in T-lymphocytic proliferation remains uncertain. The relationship between the leukemia virus, ATL/L-cells and monoclonal gammopathy is discussed.
D000368:Aged; D001798:Blood Proteins / Q000032:analysis*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology*; D007136:Immunoglobulins; D007938:Leukemia / Q000150:complications / Q000276:immunology*; D008223:Lymphoma / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes
D001798:Blood Proteins; D007136:Immunoglobulins; C009823:M-proteins (Myeloma)