Peptide priming of a poliovirus neutralizing antibody response.
Two peptides representing neutralizing epitope-containing regions of the capsid protein VP1 of type 1 poliovirus were chemically synthesized. Both peptides were found capable of priming rabbits for a significant, long-lasting, anti-virus neutralizing IgG response following a single inoculation of intact virion. In addition, a third synthetic peptide, an extended version of one of the two priming peptides, was capable of eliciting a neutralizing antibody response following inoculation of the carrier-linked peptide alone.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000917:Antibody Formation; D007074:Immunoglobulin G / Q000032:analysis; D009500:Neutralization Tests; D010455:Peptides / Q000276:immunology*; D017955:Poliovirus / Q000276:immunology*; D011817:Rabbits; D014764:Viral Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D010455:Peptides; D014764:Viral Proteins