Comparison of flupirtine maleate and dihydrocodeine in patients following surgery.
Flupirtine maleate 100 mg was compared with dihydrocodeine 60 mg when given by mouth to 50 women on the first 3 days following abdominal hysterectomy in a double-blind parallel-group trial. The analgesia produced was similar for both preparations, and the consumption of active drug was the same in both groups. The only significant differences in side-effects were an increased frequency of depression in patients receiving flupirtine and of sleepiness in those receiving dihydrocodeine.
D000328:Adult; D000631:Aminopyridines / Q000009:adverse effects / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003061:Codeine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy; D010149:Postoperative Pain / Q000188:drug therapy*
D000631:Aminopyridines; D000700:Analgesics; C034161:flupirtine; C014481:dihydrocodeine; D003061:Codeine