title: Historical and modern epidemiological studies on populations exposed to N-substituted aryl compounds.
abstract: The historical exposures to aromatic amines of various occupational groups are briefly reviewed. Modern studies indicate that other occupational groups might have risks worth investigating; these include machinists and workers in the chemical industry. Details of a recent investigation into the exposure of dye workers are given which indicate a lowered risk in recent years since the introduction of safety measures. Nonoccupational exposures to the aromatic amines are also discussed. They include cigarette smoking and phenacetin abuse, the former being a potent causal agent in bladder cancer.
mesh_terms: D000588:Amines / Q000009:adverse effects* / Q000266:history; D002274:Carcinogens, Environmental / Q000266:history; D002617:Chemical Industry; D004396:Coloring Agents; D004812:Epidemiologic Methods; D049673:History, 20th Century; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced* / Q000266:history; D012408:Rubber; D006113:United Kingdom; D014481:United States; D001749:Urinary Bladder Neoplasms / Q000266:history
chemical_list: D000588:Amines; D002274:Carcinogens, Environmental; D004396:Coloring Agents; D012408:Rubber