title: Steroidogenesis inhibitors. 1. Adrenal inhibitory and interceptive activity of trilostane and related compounds.
abstract: Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory activity.
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D000019:Abortifacient Agents / Q000494:pharmacology*; D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology*; D000311:Adrenal Glands / Q000187:drug effects*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000097:blood; D013196:Dihydrotestosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008253:Macaca mulatta; D009682:Magnetic Resonance Spectroscopy; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011555:Pseudopregnancy / Q000097:blood; D051381:Rats; D013055:Spectrophotometry, Infrared
chemical_list: D000019:Abortifacient Agents; D000021:Abortifacient Agents, Steroidal; D013196:Dihydrotestosterone; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D015096:3-Hydroxysteroid Dehydrogenases; C009954:trilostane; D003345:Corticosterone