Estimation of the local production of antibodies to Treponema pallidum in the central nervous system of patients with neurosyphilis.
In 76% of 149 patients with neurosyphilis local production of treponema-specific IgG antibodies in the central nervous system (CNS) was determined by estimating the cerebrospinal fluid (CSF)-to-serum ratio of TPHA-IgG titre per mg total IgG. With this formula synthesis of treponema-specific IgG antibodies in the CNS could be detected independently of the function of the blood-CSF barrier. A selective increase of total IgG in the CSF was not found in all cases. Forty-three patients with adequately treated or spontaneously resolved syphilis without clinical evidence of involvement of the CNS by Treponema pallidum served as controls.
D000418:Albumins / Q000134:cerebrospinal fluid; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D006386:Hemagglutination Tests; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D009494:Neurosyphilis / Q000276:immunology*; D012709:Serum Albumin / Q000032:analysis; D013587:Syphilis / Q000276:immunology; D014210:Treponema pallidum / Q000276:immunology
D000418:Albumins; D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D012709:Serum Albumin