[Determination of the antihistaminic properties of histidine derivatives on models of guinea pig T- and B-lymphocyte rosette formation].
It was found that carnosine, like metiamide, an H-2 antagonist of histamine, is capable of inhibiting the histamine caused suppression of T rosette-formation by guinea-pig blood and spleen lymphocytes. The other histidine derivatives, imidazole lactate, imidazole pyruvate and N-acetyl histidine did not exhibit such properties. The data obtained allow classifying carnosine with H-2-histamine blockers and serve as one of the explanations of the mechanism of its antiallergic action.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology*; D006639:Histidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007114:Immunization; D011968:Receptors, Histamine / Q000187:drug effects / Q000276:immunology; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D006633:Histamine Antagonists; D011968:Receptors, Histamine; D006639:Histidine
Opredelenie antigistaminnykh svoĭstv u nekotorykh proizvodnykh gistidina na modeliakh T- i B-rozetkoobrazovaniia limfotsitami morskikh svinok.