[Damaging action of dithizone on insulin-releasing cells].
Alterative action of dithizone was investigated in the experiments on various species of animals (fish, frogs, pigeons, mice, guinea pigs, golden hamsters, rats, rabbits, cats and dogs). The data received support the previously advanced suggestion that unsaturated (electrophilic) zinc complex formation is the basic mechanism of the alterative chelant's action.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D002415:Cats; D010856:Columbidae; D006224:Cricetinae; D004230:Dithizone / Q000633:toxicity*; D004285:Dogs; D005399:Fishes; D006168:Guinea Pigs; D007515:Islets of Langerhans / Q000187:drug effects*; D008647:Mesocricetus; D051379:Mice; D011817:Rabbits; D011898:Ranidae; D051381:Rats; D013045:Species Specificity
D001391:Azo Compounds; D004230:Dithizone
Povrezhdaiushchee deĭstvie ditizona na insulinvyrabatyvaiushchie kletki.