Effects of carcinogens on regenerating and non-regenerating limbs in amphibia (review).
The effects of chemical carcinogens on regenerating and non-regenerating limbs in amphibia are reviewed. The regeneration-competent tissues show a remarkable resistance to chemical carcinogenesis. However, chemical carcinogens can induce teratogenesis when they are administered to the regeneration blastema, while normal differentiation occurs in limited cases when they are administered to the intact limbs. The regenerative capacity may be considered as the deterrent to neoplasia in these tissues.
D000014:Abnormalities, Drug-Induced; D000663:Amphibians / Q000502:physiology*; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic; D005121:Extremities / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects*
D002273:Carcinogens