title: Effects of methylglyoxal bis(guanylhydrazone) on tumour and skin responses to hyperthermia in mice.
abstract: Effects of methylglyoxal bis(guanylhydrazone) (MGBG) on tumour and skin responses to hyperthermia (42 degrees C) were examined in C3H mice. MGBG (50 mg/kg) was administered intraperitoneally to mice 4 hours before hyperthermic treatment. The tumour (FM3A) growth time was elongated by an amount dependent on the exposure time of treatment at 42 degrees C (60, 90 and 120 min). Pre-treatment of mice with MGBG (50 mg/kg, i.p.) apparently further lengthened the tumour growth time after treatment at 42 degrees C. No significant damage of foot skin was caused by 42 degrees C hyperthermia. Pre-treatment with MGBG did not make the foot skin susceptible to the heating. From these findings, it can be considered that MGBG or related less-toxic compounds may have a clinical advantage for the mild (42 degrees C) hyperthermic treatment in cancer therapy.
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006979:Hyperthermia, Induced / Q000009:adverse effects; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D008935:Mitoguazone / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D012867:Skin / Q000187:drug effects / Q000293:injuries*
chemical_list: D006146:Guanidines; D008935:Mitoguazone