Susceptibility to carcinogenic effect of irradiation. Relationship to age at time of exposure.
Age at time of exposure is an important host factor influencing the subsequent cancer risk. Before completion of organogenesis, the fetus may be rather resistant, but thereafter the growing tissues of children are more susceptible than those of young adults. At greater age of adults at the time of exposure there is an increase in the subsequent absolute number of 'excess' cancer cases, but the relative risk (excess in relation to expectation) is rather constant for a given kind of radiation exposure as judged from the presently rather small number of investigations.
D000328:Adult; D000375:Aging; D000818:Animals; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007953:Leukemia, Radiation-Induced / Q000503:physiopathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000209:etiology / Q000503:physiopathology; D009381:Neoplasms, Radiation-Induced / Q000503:physiopathology*; D009689:Nuclear Warfare; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011829:Radiation Dosage; D051381:Rats; D012189:Retrospective Studies; D012306:Risk