title: A comparative multicentre trial of halometasone/triclosan cream and diflucortolone valerate/chlorquinaldol cream in the treatment of acute dermatomycoses.
abstract: In this multicentre, between-patient trial the efficacy and tolerability of a cream, containing 0.05% halometasone and 1% triclosan, was compared with those of Nerisona C cream, containing 0.1% diflucortolone valerate and 1% chlorquinaldol, in 183 patients with acute dermatomycoses. Halometasone/triclosan cream and the comparative cream showed closely similar results with respect to good to very good therapeutic effects (60% versus 57%). However, halometasone/triclosan cream proved superior to the comparative preparation with regard to very good (cured) results (53% versus 46%), an early cure in less than 30 days (41% versus 34%) and onset of action within 3 days of starting the treatment (32% versus 18%). Mycological findings were positive on direct microscopy in 36% and 43% and in culture in 19% and 17% of the patients following treatment with halometasone/triclosan cream and the comparative cream preparation, respectively. Adverse effects were reported in seven out of 108 patients treated with halometasone/triclosan cream and in five out of 107 patients treated with the comparative preparation.
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002750:Chlorquinaldol / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003881:Dermatomycoses / Q000188:drug therapy*; D004060:Diflucortolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004338:Drug Combinations; D005260:Female; D005448:Fluocortolone / Q000031:analogs & derivatives*; D006801:Humans; D006912:Hydroxyquinolines / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010647:Phenyl Ethers / Q000008:administration & dosage*; D014260:Triclosan / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D006912:Hydroxyquinolines; D010647:Phenyl Ethers; C013486:diflucortolone valerate; D014260:Triclosan; D005448:Fluocortolone; D001623:Betamethasone; D002750:Chlorquinaldol; C036518:halometasone; D004060:Diflucortolone