A metronidazole-resistant strain of Trichomonas vaginalis and its sensitivity to Go 10213.
In the present study the comparative in-vitro and in-vivo efficacy of Go 10213 was compared with those of metronidazole, secnidazole, tinidazole, ornidazole and nimorazole against a metronidazole-resistant strain of T. vaginalis. Go 10213 was found to be superior in activity. It appears more promising than the drugs mentioned above on the basis of the evidence presented.
D000818:Animals; D000994:Antitrichomonal Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice; D009593:Nitroimidazoles / Q000494:pharmacology*; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000994:Antitrichomonal Agents; D009593:Nitroimidazoles; D008795:Metronidazole; C034473:satranidazole