title: [Clinical responses and side effects of aclarubicin (ACR) in the treatment of multiple myeloma].
abstract: Fifteen patients with multiple myeloma received Aclarubicin (ACR) alone intravenously. Nine of fourteen patients (one patient with non-secretory myeloma was excluded) achieved more than a 25% reduction in M-protein (limited response = LR). Two of LR patients obtained more than a 50% reduction (good response = GR). The median total dose of ACR and the median time required to reach LR or GR were 210 mg and 28 days, respectively. One of two patients achieved a marked regression of tumor mass and two patients showed a remarkable improvement in subjective symptom. Hematological toxicities were frequently observed. However, cardiac toxicity was not detected and epilation was mild.
mesh_terms: D015250:Aclarubicin; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy*; D009279:Naphthacenes / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D009279:Naphthacenes; D015250:Aclarubicin