[Analysis of the paradoxical stage of neural cathodal parabiosis (the reciprocal inhibition of adjacent fibers)].
A preparation consisting of VIII-IX dorsal and ventral roots, the sciatic nerve and a single fiber of the tibial nerve was used to study changes in conduction reliability in a single nerve fiber by means of steady-state depolarization ("cathodal alteration") of the central part of the sciatic nerve: the depolarization led to a partial block of nerve fibers and to lowering of the safety factor in the single fiber tested. While a spinal root containing the fiber under study was stimulated with trains of stimuli (200/s) the number of APs traveling along the fiber depended on the stimulation strength, being maximal near the threshold. This suggests the influence of neighbouring fiber excitation on the conduction in the tested one. The effect was more obvious when all four roots were stimulated. The paradoxical decrease in the conducted APs caused by intensification of the stimulation, seems to reflect the electrical interaction between activated fibers. Possible mechanism of this interaction is discussed.
D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D004566:Electrodes; D004594:Electrophysiology; D066298:In Vitro Techniques; D009412:Nerve Fibers / Q000502:physiology*; D009433:Neural Inhibition; D010227:Parabiosis; D011896:Rana temporaria; D012584:Sciatic Nerve / Q000502:physiology; D013126:Spinal Nerve Roots / Q000502:physiology; D013979:Tibial Nerve / Q000502:physiology
K analizu paradoksal'noĭ stadii katodnogo parabioza nerva (o vzaimnom tormozheniia sosednikh volokon).