[Perioperative cefamandole prevention in aortocoronary bypass operations: the course of serum levels in extracorporeal circulation].
Antibiotic prophylaxis with 2 g Cefamandole at induction of anaesthesia was performed in 12 male patients undergoing aortocoronary bypass surgery. Caused by hemodilution, there was a marked decrease of serum concentration at the beginning of extracorporeal circulation, from 110.96 +/- 40.29 mcg/ml to 70.89 +/- 34.65 mcg/ml within 10 min. During extracorporeal circulation, elimination was as fast as before and after perfusion. 240 min after application, mean serum concentrations of 16.80 +/- 9.32 mcg/ml were measured. Failure of antibiotic prophylaxis in operations exceeding 4 h might be due to unadaequate antibiotic concentrations, beyond the minimal inhibitory concentration for the pathogens, reported to cause infections after cardiac operations.
D000328:Adult; D002435:Cefamandole / Q000097:blood / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D005112:Extracorporeal Circulation; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control*
D002435:Cefamandole
Perioperative Cefamandolprophylaxe bei aortocoronaren Bypass-Operationen: Serumkonzentrationsverlauf während der extrakorporalen Zirkulation.