Alpha-1-antitrypsin levels and clinical symptoms in forty-eight children with selective IgA deficiency.
Previous studies in adult patients with selective IgA deficiency have pointed towards a possible connection between combined IgA and alpha-1-antitrypsin deficiency and the development of bronchiectasis. Thus, investigations were conducted of serum alpha-1-antitrypsin levels and clinical symptoms in 48 children with selective IgA deficiency. However, alpha-1-antitrypsin deficiency was not found in this group of patients. Furthermore, radiographic signs of recurrent pneumonia restricted to certain fields of the lungs, suggestive of bronchiectasia, were not observed in the patients. Thus, although a highly selected group of children with selective IgA deficiency was studied, a connection between IgA deficiency and alpha-1-antitrypsin deficiency was not obvious.
D000293:Adolescent; D001249:Asthma / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000175:diagnosis*; D006801:Humans; D017098:IgA Deficiency; D007073:Immunoglobulin E / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000175:diagnosis; D019896:alpha 1-Antitrypsin Deficiency
D007075:Immunoglobulin M; D007073:Immunoglobulin E