The effect of maternal steroid administration on fetal platelet count in immunologic thrombocytopenic purpura. Management of pregnancy and mode of delivery.
Eight pregnancies complicated by immunologic thrombocytopenic purpura are described and the literature is reviewed. We conclude that, while steroid treatment favorably influenced fetal platelet counts in our cases, overall experience with this disease indicates that such protection is incomplete in some cases and unnecessary in others. Antiplatelet antibody levels show promise as excellent indicators of fetal thrombocytopenia, and elevated levels may be an indication for steroid therapy for the improvement of fetal well-being in some cases.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001724:Birth Weight; D001792:Blood Platelets / Q000187:drug effects* / Q000276:immunology; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D010976:Platelet Count; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy* / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy* / Q000276:immunology
D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D011241:Prednisone