Increased frequency of HLA-Bw62 and Bw35 CREG antigens in HLA-B27 negative ankylosing spondylitis.
67 patients with ankylosing spondylitis (AS) were tissue-typed for HLA-A, -B and -C antigens. HLA-Bw62 was found in 6 of 13 (46%) HLA-B27 negative patients, compared to 9% in HLA-B27 positive AS (p greater than 0.01) and 10% in healthy blood donors (p greater than 0.001). HLA-Bw62, a split of the previous HLA-B15, belongs to the HLA-Bw35 CREG antigens, 11 of 13 (85%) of HLA-B27 negative patients had an HLA-Bw35 CREG antigen. The present results are interpreted as an indication of a direct involvement of the HLA-B locus in the pathogenesis of AS.
D000328:Adult; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D015796:HLA-B27 Antigen; D015797:HLA-B35 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013167:Spondylitis, Ankylosing / Q000235:genetics*
D006680:HLA Antigens; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D015796:HLA-B27 Antigen; D015797:HLA-B35 Antigen; C044141:HLA-Bw62