Augmentation of antitumor activities in hamster macrophages by yeast cell walls treated with lymphokines in vitro.
The effect of the treatment of yeast cell walls (YCW) with PPD-induced lymphokines (LK) was studied. The rate of macrophage spreading increased 1 h and 24 h after incubation with YCW treated with 16-fold or 64-fold diluted LK. Phagocytosis was slightly enhanced after 1 h incubation. Cytostatic activity was obtained when incubated with YCW treated with 16-fold or 64-fold diluted LK, but not with LK of higher or lower dilution. Tumor-inhibitory effect was observed when lymphoma cells were mixed with LK-treated YCW and inoculated s.c.
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D005260:Female; D008222:Lymphokines / Q000494:pharmacology*; D008223:Lymphoma / Q000276:immunology / Q000628:therapy*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy; D010587:Phagocytosis; D012441:Saccharomyces cerevisiae / Q000276:immunology*
D008222:Lymphokines