Effects of midecamycin acetate (miocamycin), a new macrolide antibiotic, on reproductive performances in rats and rabbits.
Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the effect of MOM on reproductive performance in rats and rabbits. MOM, non-crystalline solid, was suspended in 0.1% CMC solution immediately before use. In this study, reproductive performance was studied according to the following designs: Fertility test (Segment I) in Wistar rats Teratogenicity test (Segment II) in Wistar rats Peri- and post-natal tests (Segment III) in Wistar rats Behavioral test in rat newborns in Segments II and III Teratogenicity test (Segment II) in New Zealand white rabbits In conclusion, MOM, non-crystalline solid, might have no teratogenesis and little influence on dams and their fetuses and offsprings.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005333:Fetus / Q000187:drug effects; D007933:Leucomycins / Q000633:toxicity*; D008297:Male; D015644:Miocamycin; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D007933:Leucomycins; D015644:Miocamycin