H-2-restricted graft-versus-host reaction: foreign determinants and restriction elements.
Nylon-wool-purified T cells from radiation chimeras cause a lethal graft-versus-host reaction (GVHR) in irradiated, bone-marrow-protected recipients only if the recipient shares a restriction element with the T-cell donor and also expresses antigens foreign to the donor. Class I molecules (H-2K and H-2D) can act as restriction elements, but restriction to class II molecules could not be demonstrated. However, class II molecules as well as H-2K and some non-H-2 determinants could serve as foreign antigens.
D000818:Animals; D016026:Bone Marrow Transplantation; D005260:Female; D005333:Fetus; D006087:Graft vs Host Reaction / Q000528:radiation effects; D006183:H-2 Antigens / Q000276:immunology* / Q000528:radiation effects; D008099:Liver / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011828:Radiation Chimera; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects
D006183:H-2 Antigens