Protoanemonin, an antimutagen isolated from plants.
Protoanemonin was identified as the factor responsible for the antimutagenicity of Ranunculus and Anemone plants against the strain E. coli B/r WP2 trp. The specific activities found were AD50 = 30 and 47 microgram/plate, respectively, for UV- and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutations. Quantitative analyses of protoanemonin in the crude extracts of Ranunculus and Anemone plants were performed by reversed-phase high-pressure liquid chromatography.
D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli / Q000187:drug effects* / Q000528:radiation effects; D005663:Furans / Q000494:pharmacology*; D008769:Methylnitronitrosoguanidine; D009154:Mutation; D010947:Plants, Toxic / Q000032:analysis*; D014466:Ultraviolet Rays
D005663:Furans; D008769:Methylnitronitrosoguanidine; C037354:protoanemonin