[Determination of the antigenic composition of the hemagglutinins of influenza viruses H1N1].
A comparative immunological analysis of the antigenic composition of hemagglutinins (HA) of influenza A viruses isolated from man and animals was done by the method of specific adsorption of immunoglobulin fractions recovered from sera of rabbits and rats immunized with influenza H1N1 viruses isolated in 1930-1948. A single determinant which remains antigenically stable from 1930 up to the present time was found in HA of human influenza H1N1 viruses (1933-1957, 1977-1981), swine virus A/Swine/Iowa/30, and whale virus A/whale/Pacific Ocean/8/76. Animal influenza viruses A/swine/Iowa/30 and A/whale/Pacific Ocean/8/76 have in their HA one more determinant contributing to the similarity of the swine virus with human A/PR8/34 virus, and the whale virus with human A/W.Smith/33 virus.
D000327:Adsorption; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D006389:Hemagglutinins, Viral / Q000032:analysis*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007158:Immunologic Techniques; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000276:immunology*; D011817:Rabbits; D051381:Rats
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D007074:Immunoglobulin G
Opredelenie antigennogo sostava gemaggliutninov virusov grippa H1N1.