Ankylosing spondylitis is part of a multifactorial syndrome: hereditary multifocal relapsing inflammation (HEMRI).
Complex associations between the different subgroups of seronegative arthritis, acute anterior uveitis, psoriasis and inflammatory bowel disease were found in a series of patients and relatives. Different HLA-B antigens were associated with different clinical signs. The results indicated the existence of a multigenic syndrome whose main clinical manifestations are relapsing innflammations at various sites. The genetic factors appeared to be 1) HLA-B27 associated disease susceptibility, 2) predisposition to psoriatic arthropathy, 3) predisposition to early onset familial psoriasis and, 4) a probable predisposition to inflammatory bowel disease and its associated arthropathy. The results indicated that the different genetic factors may interact and influence each other's penetrance and expression.
D001168:Arthritis / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics; D015796:HLA-B27 Antigen; D006801:Humans; D007249:Inflammation / Q000235:genetics; D007410:Intestinal Diseases / Q000235:genetics; D008297:Male; D011472:Prostatitis / Q000235:genetics; D011565:Psoriasis / Q000235:genetics; D012008:Recurrence; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D013577:Syndrome; D014606:Uveitis, Anterior / Q000235:genetics
D006680:HLA Antigens; D015796:HLA-B27 Antigen