HLA-DR-positive cells in the human amniochorion.
Human amniochorion has been studied by indirect immunofluorescence using a monoclonal antibody to a monomorphic determinant of HLA-DR antigens. Positive staining was noted only on significant numbers of large cells with irregular cytoplasmic processes in the mesenchymal connective tissue layer of the membranes. These cells resemble the dendritic-type, strongly HLA-DR-positive cells described by Steinman [3] and may be particularly relevant in immunobiological events at this important materno-foetal interface.
D000650:Amnion / Q000166:cytology / Q000276:immunology*; D000911:Antibodies, Monoclonal; D002823:Chorion / Q000166:cytology / Q000276:immunology*; D003238:Connective Tissue / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D006801:Humans; D011247:Pregnancy
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II