Identification of a cathepsin b-like protease in the crevicular fluid of gingivitis patients.
Crevicular fluid from gingivitis patients contains significant levels of a cysteine protease which was characterized as the lysosomal protease cathepsin B, as judged by substrate specificity, thiol dependence, pH optimum, kinetic parameters, pH stability, and inhibitor sensitivities. A highly-sensitive fluorometric assay procedure was used to establish the mean level of cathepsin B activity for 25 gingivitis patients.
D002401:Cathepsin B; D002403:Cathepsins / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000378:metabolism; D005883:Gingival Crevicular Fluid / Q000032:analysis*; D005891:Gingivitis / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration
D002403:Cathepsins; D002401:Cathepsin B