Calcium antagonists in hypertensive disease: experimental evidence for a new therapeutic concept.
In animal experiments calcium antagonist drugs decrease peripheral vascular resistance, improve renal sodium excretion and thus, diminishing the volume load, reduce cardiac hypertrophy. In experimental malignant hypertension these drugs preserve tissue integrity by inhibiting the deleterious calcium overload of vessels.
D000818:Animals; D001158:Arteries / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006974:Hypertension, Malignant / Q000188:drug therapy; D008297:Male; D051381:Rats; D014652:Vascular Diseases / Q000188:drug therapy / Q000209:etiology
D002121:Calcium Channel Blockers; D002118:Calcium