Surface immunoglobulin and the lymphocyte cytoskeleton.
Surface immunoglobulin, the key surface receptor of B lymphocytes, undergoes ligand-dependent interaction with the cell cytoskeleton. The capacity of this receptor to associate with and activate the contractile apparatus mediates its unique influence on the lymphocyte physiology: membrane reorganization, chemotaxis, and receptor-ligand endocytosis. Features of this receptor-cytoskeleton interaction are probed with a simple but powerful detergent fractionation technique.
D000818:Animals; D002634:Chemotaxis, Leukocyte; D003599:Cytoskeleton / Q000378:metabolism*; D004705:Endocytosis; D005455:Fluorescent Antibody Technique; D008214:Lymphocytes / Q000166:cytology*; D008565:Membrane Proteins / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*
D008565:Membrane Proteins; D011947:Receptors, Antigen, B-Cell