Synthesis of high purity 11C labeled palmitic acid for measurement of regional myocardial perfusion and metabolism.
Palmitic acid is a major physiological substrate of the myocardium and its role in myocardial metabolism is well understood. 11C labeled palmitic acid may be used with a positron emission tomograph (PET) to obtain high contrast images of transverse sections of the heart. A rapid and reliable method for producing [11C]palmitic acid from [11C]carbon dioxide by the Grignard synthesis is described. All interfering long chain nonradioactive impurities are removed by the purification procedure. As a result, this [11C]palmitic acid may be used as a tracer for pure palmitic acid in the measurement of regional myocardial function.
D000818:Animals; D002250:Carbon Radioisotopes; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging*; D007202:Indicators and Reagents; D009206:Myocardium / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000138:chemical synthesis; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D007202:Indicators and Reagents; D010169:Palmitic Acids; D019308:Palmitic Acid