[Insulin receptors of fat cells plasma membranes in patients with diabetes mellitus with various insulin requirements].
Maximum specific and non-specific 125I-insulin binding by the fatty cell plasmatic membranes was determined in 10 insulin-treated patients with diabetes mellitus and insulin receptors were studied in 5 of them by means of saturation analysis. It was shown that the concentration of insulin receptors in the patients under examination was lowered and their affinity to insulin and negative cooperating interaction between them remained unchanged comparatively to those of patients without endocrine pathology. There was no correlation between a daily dose of insulin injected and the value of the maximum specific 125I-insulin binding.
D000273:Adipose Tissue / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D001667:Binding, Competitive; D002462:Cell Membrane / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011972:Receptor, Insulin / Q000032:analysis* / Q000502:physiology
D007328:Insulin; D011972:Receptor, Insulin
Insulinovye retseptory plazmaticheskikh membran zhirovykh kletok u bol'nykh sakharnym diabetom s razlichnoĭ potrebnost'iu v insuline.