Apparent absence of recombinogenic activity of nitropyrenes for yeast.
Nitropyrenes have been shown to be potent bacterial and mammalian mutagens. However, they failed to induce any recombinogenic activity in Saccharomyces cerevisiae D4 even at elevated concentrations and following extended periods of exposure. A plausible explanation for this lack of activity is the absence or the lack of activation of the enzyme required for the activation of nitropyrenes in this test system under the experimental (aerobic) conditions employed.
D005796:Genes / Q000187:drug effects; D011721:Pyrenes / Q000494:pharmacology*; D011995:Recombination, Genetic / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*; D013329:Structure-Activity Relationship
D011721:Pyrenes