Do prostaglandins affect cellular radiosensitivity in vitro?
We have been unable to detect any change in the in vitro radiation response of mouse fibrosarcoma cells, HSDM1C1, which secrete 2 micrograms PGE2/mg cell protein/24 h, in the presence of the prostaglandin biosynthesis inhibitor flurbiprofen. Furthermore, addition of exogenous PGE1 or PGA2 to cultures of Chinese hamster cells was similarly without effect on radiation response. Although a high concentration of PGA2 inhibited the growth of Chinese hamster cells in vitro this effect disappeared upon removal of the prostaglandin. The implications of these results for radiotherapy are discussed.
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D005480:Flurbiprofen / Q000494:pharmacology; D005720:Gamma Rays; D005978:Glutathione / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology; D051379:Mice; D011453:Prostaglandins / Q000502:physiology*; D011454:Prostaglandins A / Q000502:physiology; D011458:Prostaglandins E / Q000502:physiology; D012513:Sarcoma, Experimental / Q000532:radiotherapy*
D011453:Prostaglandins; D011454:Prostaglandins A; D011458:Prostaglandins E; D005480:Flurbiprofen; D005978:Glutathione