[In vitro treatment of human bone marrow in the elimination of tumor cells: initial experiences with cytotoxic monoclonal anti-T-cell antibody LAU-A1].
The authors present evidence that elimination of tumor cells in the bone marrow is essentially possible by in vitro purging with the monoclonal anti-T-cell antibody LAU-A1 and complement; this procedure does not interfere with regeneration capacity of stem cells. These findings have an important bearing with regard to candidates for autologous bone marrow transplantation.
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000912:Antibodies, Neoplasm / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology*; D002648:Child; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008223:Lymphoma / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm
In-vitro-Behandlung von menschlichem Knochenmark zur Elimination von Tumorzellen: erste Erfahrungen mit dem zytotoxischen monoklonalen Anti-T-Zell-Antikörper LAU-A1.