title: Quinine loading dose in cerebral malaria.
abstract: In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.
mesh_terms: D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D008433:Mathematics; D010963:Plasmodium falciparum; D011803:Quinine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood
chemical_list: D011803:Quinine