Effect of whole body hyperthermia and BCNU on the development of radiation myelitis in the rat.
A radiant heat device was used to study the interaction of 41.8 degrees C whole body hyperthermia (WBH), radiation (40 Gy) and the lipophilic anti-neoplastic agent BCNU in the development of myelitis in the rat spinal cord. The addition of WBH and BCNU neither precipitated myelitis acutely nor shortened the latency before the onset of neurological signs in irradiated animals.
D000818:Animals; D002330:Carmustine / Q000009:adverse effects*; D005260:Female; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D009187:Myelitis / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000528:radiation effects*; D014965:X-Rays
D002330:Carmustine