[Cross-reactivity of 3M KCl extracts of fetal tissue from various species in the macrophage electrophoresis mobility (MEM) test. I. Extracts from fetuses of mammals and one species of fowl].
Extracts were prepared by the 3M KCl method from fetal tissues of human, mouse, cattle, pig, sheep, cat, guinea pig, and chicken origin. Lymphocytes of tumor bearing mice and tumor patients reacted specifically in the MEM-test with antigenic components of the extracts. The cellular sensitization of the tumor-bearer was not correlated with the localization and the histologic type of the tumor. The cross-reacting oncofetal antigens obviously represent phylogenetically conserved structures.
D000818:Animals; D002415:Cats; D002417:Cattle; D002478:Cells, Cultured; D002642:Chick Embryo; D003429:Cross Reactions; D005260:Female; D005333:Fetus / Q000276:immunology*; D006168:Guinea Pigs; D006801:Humans; D007158:Immunologic Techniques; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009369:Neoplasms / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology; D011247:Pregnancy; D012756:Sheep; D013045:Species Specificity; D013552:Swine
Kreuzreaktivität von 3M KCl-Extrakten aus Fötalgewebe verschiedener Spezies im Makrophagen-Elektrophorese-Mobilitäts-(MEM-) Test.