Teratocarcinoma transplantation antigens are encoded in the H-2 region.
Evidence is presented for the existence of teratocarcinoma transplantation antigens (Gt) encoded within the H-2 complex and present also on adult tissues. It has not been possible to separate these Gt loci from H-2 by recombination, and Gt factors map to each end of the H-2 complex. Previous reports indicating separation of all Gt loci from H-2 are reinterpreted. One class of such apparent recombinants has been shown to result from the outgrowth of tumor variants in mice of resistant genotype.
D000818:Animals; D002460:Cell Line; D003433:Crosses, Genetic; D005455:Fluorescent Antibody Technique; D006183:H-2 Antigens / Q000235:genetics*; D006579:Heterozygote; D006649:Histocompatibility Antigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D016038:Skin Transplantation; D013045:Species Specificity; D013724:Teratoma / Q000276:immunology*; D014185:Transplantation, Isogeneic
D006183:H-2 Antigens; D006649:Histocompatibility Antigens