Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-11. Toxicity of metabolites of miocamycin: acute toxicity of Mb12 in rats.
Miocamycin (MOM) is a derivative of midecamycin and is metabolized into 4 main metabolites of Mb1, Mb2, Mb6 and Mb12. In the previous studies, LD50 values of Mb12 were 5,750 mg/kg in male mice and 4,950 mg/kg in female mice, respectively. The object of this study was to evaluate acute toxicity in male and female rats after single oral administration of Mb12. Observations were continued for 1 week after treatment. It is concluded that LD0 values of Mb12 were estimated more than 5,000 mg/kg.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000473:pathology; D005260:Female; D007928:Lethal Dose 50; D007933:Leucomycins / Q000378:metabolism / Q000633:toxicity*; D008168:Lung / Q000473:pathology; D008297:Male; D015644:Miocamycin; D051381:Rats; D011919:Rats, Inbred Strains
D000900:Anti-Bacterial Agents; D007933:Leucomycins; D015644:Miocamycin