title: A comparison of the effects of corticotropin releasing factor and sauvagine on food intake.
abstract: Corticotropin releasing factor (CRF) and sauvagine (SVG) when administered ICV both reduced spontaneous feeding as well as feeding induced by deprivation or the administration of ethylketocyclazocine (EKC). For spontaneous- and EKC-induced feeding, SVG produced a larger and longer-lasting suppressive effect than did CRF. Both peptides produced a conditioned taste aversion when paired with a novel saccharin taste. As the feeding effects, SVG produced a stronger aversion than CRF. These studies further establish the similarity between CRF and SVG and suggest that they may have a disruptive effect on feeding.
mesh_terms: D029845:Amphibian Proteins; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D003496:Cyclazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D016314:Ethylketocyclazocine; D005247:Feeding Behavior / Q000187:drug effects*; D005508:Food Deprivation; D008297:Male; D036361:Peptide Hormones; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D029845:Amphibian Proteins; D036361:Peptide Hormones; D010455:Peptides; D016314:Ethylketocyclazocine; C025727:sauvagine; D003346:Corticotropin-Releasing Hormone; D003496:Cyclazocine