Successful human kidney preservation by intracellular electrolyte flush followed by cold storage for more than 48 hours.
Transplantation of cadaver kidneys after flushing with an ice-cold intracellular electrolyte solution is inhibited by arbitrary time limits on cold ischemia. During the 25-month interval ending March 22, 1982 we transplanted 7 kidneys preserved by this method and cold-stored for 48.2 to 61.4 hours. Of the recipients 86 per cent required dialysis within 1 week after transplantation, the mean serum creatinine nadir within 1 month was 2.1 mg./dl. and the graft survival at 1 month was 71 per cent. The 1-year actuarial cadaver graft survival was 69.2 plus or minus 18.1 per cent. Kidneys preserved by this simple method can be transplanted successfully after 48 hours of simple cold storage.
D003080:Cold Temperature; D004573:Electrolytes; D006801:Humans; D007424:Intracellular Fluid; D016030:Kidney Transplantation; D009926:Organ Preservation / Q000379:methods*; D013997:Time Factors; D014021:Tissue Preservation / Q000379:methods*
D004573:Electrolytes