title: [Molecular nature of the mutations in gene ADE2 in Saccharomyces cerevisiae yeasts. III. Determination of the correlation of the GC AT pairs in genes ADE1 and ADE2].
abstract: Lethal and mutagenic effects and the nature of mutations induced by decay of 32P incorporated into yeast cell DNA as 32P-deoxyguanosine monophosphate (32PdGMP) and 32P-thymidine monophosphate (32P-TMP), were studied. The lethal efficiency per 32P decay is independent of a labelled nucleotide incorporated into DNA. However, the mutagenic efficiency in ADE1, ADE2 genes per 32P decay is approximately 3 times greater for 32PdGMP than for 32P-TMP. This suggests that ADE1, ADE2 genes contain about 3 times more GC base pairs than AT pairs. Variations in a relative frequencies of GC leads to AT and AT leads to GC transitions were obtained depending upon a nucleotide labelled.
mesh_terms: D000227:Adenine Nucleotides / Q000235:genetics* / Q000528:radiation effects; D003597:Cytosine Nucleotides / Q000235:genetics* / Q000528:radiation effects; D004271:DNA, Fungal / Q000235:genetics / Q000528:radiation effects; D005796:Genes / Q000528:radiation effects; D006150:Guanine Nucleotides / Q000235:genetics* / Q000528:radiation effects; D009154:Mutation; D010761:Phosphorus Radioisotopes; D011336:Probability; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000528:radiation effects; D013942:Thymine Nucleotides / Q000235:genetics* / Q000528:radiation effects
chemical_list: D000227:Adenine Nucleotides; D003597:Cytosine Nucleotides; D004271:DNA, Fungal; D006150:Guanine Nucleotides; D010761:Phosphorus Radioisotopes; D013942:Thymine Nucleotides
vernacular_title: Izuchenie molekuliarnoĭ prirody mutatsiĭ v gene ADE2 u drozhzheĭ Saccharomyces cerevisiae. Soobshchenie III. Opredelenie sootnosheniia par GTs i AT v genakh ADE1 i ADE2.