Experimental chemotherapy of radiation injury with synthetic lysophospholipid analogs in mice.
Synthetic lysophospholipids represent a variety of analogs of the naturally occurring 2-lysophosphatidylcholine. Some of these compounds showed significant therapeutic effects on the survival of mice following radiation injury when administered after various doses of whole-body X irradiation. Such therapeutic effects were discernible even when the treatment was given 6 hr after irradiation, and both intravenous and oral application were effective. Intravenous application of 2 X 25 mg/kg lysophospholipid after whole-body X irradiation around the LD50 resulted in significantly higher numbers of surviving animals. The mode of action remains speculative.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007275:Injections, Intravenous; D008244:Lysophosphatidylcholines / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D011832:Radiation Injuries / Q000188:drug therapy*; D013997:Time Factors; D014916:Whole-Body Irradiation
D008244:Lysophosphatidylcholines