Comparative side effects of imipramine, benztropine, or their combination in patients receiving fluphenazine decanoate.
Patients receiving fluphenazine decanoate who were switched from adjunctive benztropine to imipramine in a double-blind trial experienced marked exacerbations of extrapyramidal side effects. No substantial increase in anticholinergic side effects occurred, however, when imipramine was added to fluphenazine decanoate and benztropine.
D000328:Adult; D001590:Benztropine / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D005476:Fluphenazine / Q000031:analogs & derivatives; D006801:Humans; D007099:Imipramine / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014326:Tropanes / Q000009:adverse effects*
D014326:Tropanes; D001590:Benztropine; C011825:fluphenazine depot; D007099:Imipramine; D005476:Fluphenazine