title: [Sodium nitroprusside in hypothermic surgery under extracorporeal circulation].
abstract: Sodium nitroprusside (SNP) is a vasodilator widely used in heart surgery. Its effects before and after bypass at normal temperature have been reported. This prospective study compares 15 patients who received SNP with 5 controls. SNP's efficacy on the systemic arterial resistance index is demonstrated during cooling and rewarming. Vasoconstriction at the end of persistent hypothermia does not respond to SNP. No signs of toxicity, neither biological (metabolic acidosis) nor clinical (respiratory or cardiac problems) were observed. SNP lowers pulmonary artery resistance index during normothermia and pulsed cardiac output, but a rebound appears 45 minutes after SNP withdrawal. SNP is usefull for anaesthesia in heart surgery with hypothermia.
mesh_terms: D000328:Adult; D000368:Aged; D001160:Arterioles; D001026:Coronary Artery Bypass; D005112:Extracorporeal Circulation; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D006351:Heart Valves / Q000601:surgery; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000494:pharmacology*; D011446:Prospective Studies; D014655:Vascular Resistance / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D005292:Ferricyanides; D009599:Nitroprusside
vernacular_title: Le nitroprussiate de sodium chez l'opéré en hypothermie sous circulation extracorporelle.