The effect of interleukin 1(IL-1) containing supernatants on murine thymocyte maturation.
IL-1 containing supernatants were produced by E. coli lipopolysaccharide (LPS) stimulated adherent human mononuclear cells. Thymocytes from 4--6-week-old BALB/c mice were pretreated with IL-1 containing supernatants or control supernatants. IL-1 containing supernatant pretreated thymocytes when added to enriched splenic B cells increased the proliferative response of these cells after PWM activation. IL-1 pretreated thymocytes furthermore, increased the number of immunoglobulin secreting cells in the mouse splenocyte population, as compared to control supernatant pretreated thymocytes. These results indicate that IL-1 matures thymocytes into predominantly helper cells which augment B cell proliferation and antibody production.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D007375:Interleukin-1 / Q000502:physiology*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*
D007375:Interleukin-1