Inhibitory action of serum from a Laron dwarf on normal cellular function.
Glucose uptake and O2 consumption of confluent glial cells grown in culture were measured in the presence of serum-free buffer and compared with those measured in the presence of serum from a normal volunteer, from an hGH-deficient dwarf and from a Laron dwarf. Cellular glucose uptake and respiration in the absence or presence of insulin or hGH are inhibited by Laron serum.
D001769:Blood; D002460:Cell Line; D004392:Dwarfism / Q000097:blood*; D005947:Glucose / Q000378:metabolism*; D013006:Growth Hormone / Q000172:deficiency / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects
D007328:Insulin; D013006:Growth Hormone; D005947:Glucose