Effect of cyclophosphamide on murine nephrotoxic nephritis.
We studied the effect of cyclophosphamide (CPM) on development of severe glomerular lesions in a model of murine nephrotoxic nephritis (NTN). CPM treatment (300 mg/kg) before initiation of the first phase on NTN showed no host antibody depositions along the glomerular basement membrane, as revealed by immunofluorescence; however, the histological study revealed no significant difference in the degree of renal damage between the control and the CPM-treated mice. Therefore, the severe glomerular lesions in murine NTN may be induced without antibody response to nephrotoxin, in the glomerulus.
D000818:Animals; D003176:Complement C3 / Q000276:immunology; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007668:Kidney / Q000648:ultrastructure*; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009393:Nephritis / Q000139:chemically induced / Q000473:pathology
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003520:Cyclophosphamide