[Effects of a diet with various polyunsaturated fatty acid contents on the secretion of prostaglandins and ATPase activity in the rat myocardium in total ischemia].
Experiments were made on the heart perfused according to Langendorf's method of adult Wistar and Okamoto-Aoki rats with hereditary arterial hypertension given the diets with varying content of polyunsaturated fatty acids (PUFA). It was demonstrated that under total heart ischemia, there was a maximal increase in the output of prostacycline and prostaglandin E (PGE) by the hearts of hypertensive rats given the diet enriched with linoleic acid. The rats given the PUFA deficient diet and the diet enriched with linoleic acid did not show any substantial changes in PG secretion by the ischemized heart. It was also disclosed that under normoxic perfusion, Na, K-ATPase activity in the heart of hypertensive rats was increased, being significantly inhibited during total heart ischemia. According to the authors, the differences in the changes in PG secretion and Na, K-ATPase activity might be related to a possible effect of lipid diet components and to variations in PUFA content in heart phospholipids.
D000818:Animals; D003327:Coronary Disease / Q000201:enzymology / Q000503:physiopathology*; D004041:Dietary Fats / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D011453:Prostaglandins; D000254:Sodium-Potassium-Exchanging ATPase
Vliianie diet s razlichnym soderzhaniem polinenasyshchennykh zhirnykh kislot na vydelenie prostaglandinov i aktivnost' ATF-az v tkani serdtsa krys pri total'noĭ ishemii organa.