Allogeneic segmental pancreas transplantation in diabetic dogs with and without occlusion of the pancreatic duct.
Currently the rate of complications in segmental pancreas transplantation is very high. Reasons for this come from technical failures and from the site of immunology. To prove the cause of technical complications, several methods were used for the allogeneic segmental pancreas transplantation in diabetic dogs. To influence the exocrine pancreas secretion in grafts, we applied the intraductal injection of Ethibloc and Neoprene and the intraperitoneal drainage. By all these approaches it was possible to ameliorate an experimental diabetes in the recipients. Clearly better results were achieved in the Ethibloc-injected and open-duct grafts. The longest function time was about 6 months. Main complications, especially in the Neoprene-injected group, were venous thrombosis, pancreatitis and graft rejection.
D000818:Animals; D001786:Blood Glucose; D003973:Diatrizoate; D004285:Dogs; D004338:Drug Combinations; D005227:Fatty Acids; D006084:Graft Rejection; D007328:Insulin / Q000097:blood; D009387:Neoprene / Q000008:administration & dosage / Q000009:adverse effects; D010179:Pancreas / Q000473:pathology; D016035:Pancreas Transplantation; D010182:Pancreatic Diseases / Q000503:physiopathology; D010183:Pancreatic Ducts / Q000502:physiology / Q000503:physiopathology*; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D011409:Propylene Glycols; D011506:Proteins / Q000008:administration & dosage; D015028:Zein
D001786:Blood Glucose; D004338:Drug Combinations; D005227:Fatty Acids; D007328:Insulin; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D015028:Zein; D009387:Neoprene; C020481:alcoholic prolamine solution