[Action of doxorubicin on immunogenesis].
The effect of doxorubicin, carminomycin and rubomycin on some immunological reactions was studied comparatively on mice. It was shown that doxorubicin had an immunodepressant effect on the synthesis of antibodies and antibody-forming cells. By the character of its immunodepressant effect doxorubicin was similar to rubomycin. In a dose of 0.3 of the LD50 doxorubicin had no effect on the transplantation immunity in the system of "transplant versus host" and did not prolong the lifetime of the skin graft.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002360:Carubicin / Q000276:immunology; D003630:Daunorubicin / Q000276:immunology; D004317:Doxorubicin / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006084:Graft Rejection / Q000187:drug effects; D006087:Graft vs Host Reaction / Q000187:drug effects; D006388:Hemagglutinins / Q000032:analysis; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D016038:Skin Transplantation; D013997:Time Factors; D014181:Transplantation Immunology / Q000187:drug effects
D006388:Hemagglutinins; D004317:Doxorubicin; D002360:Carubicin; D003630:Daunorubicin
Deĭstvie doksorubitsina na immunogenez.