Humoral and cellular immune mechanisms in children with spastic bronchitis.
Twenty children with spastic bronchitis were examined to determine T and B lymphocytes, serum immunoglobulins and the presence of antibodies against autologous lymphocytes. T lymphocytes and B lymphocytes with surface IgA were observed to decrease while B lymphocytes with surface IgG increased. Besides, the level of serum A immunoglobulins was elevated but antibodies against autologous lymphocytes were not detected. In 7 severe cases Levamisol was applied. The treatment appeared effective in 6 children. Clinical improvement was accompanied by substantial alterations in the behaviour of the examined elements of the immunological system, i.e. increase of T and B lymphocytes, increased concentration of serum IgM in 5 and IgA in 4 patients.
D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D001986:Bronchial Spasm / Q000150:complications / Q000276:immunology*; D001991:Bronchitis / Q000150:complications / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G