title: [Clinical experiences with carteolol in patients with essential hypertension].
abstract: Publications dealing with investigations made with 5-(3-tert-butylamino-2-hydroxy-propoxy)-3, 4-dihydro-2(1H)-quinolinone hydrochloride (carteolol hydrochloride, Endak, Endak mite) on patients with essential hypertension, are briefly reviewed. Four controlled studies are considered in greater depth. A comparative study with pindolol indicates that the beta-receptor blocker carteolol led to a significant reduction of the elevated blood pressure of patients with essential hypertension, as did pindolol. The antihypertensive effect of carteolol, however, was seen in a significantly higher number of patients than that of pindolol (p less than 0.05). A further controlled clinical study of carteolol, this time in comparison with diuretics, also demonstrated its satisfactory antihypertensive effect. It was found that carteolol displayed a significantly greater (p less than 0.05 and p less than 0.001) effectivity in reducing the blood pressure than did previously prescribed diuretics. In another test the antihypertensive effect was established by comparison with a placebo (p less than 0.001). Moreover, a study has been made of the effect of carteolol on the renin-aldosterone system. The results established that the hypotensive effect of carteolol is not associated with an inhibition of the renin-aldosterone system.
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002354:Carteolol / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology; D010869:Pindolol / Q000627:therapeutic use; D011412:Propanolamines / Q000627:therapeutic use*; D013997:Time Factors; D000092502:Renin Inhibitors
chemical_list: D002354:Carteolol; D000451:Mineralocorticoid Receptor Antagonists; D010869:Pindolol; D011412:Propanolamines; D000092502:Renin Inhibitors
vernacular_title: Klinische Erfahrungen mit Carteolol bei Patienten mit essentieller Hypertonie.