title: Mass medication in reducing shipping fever-bovine respiratory disease complex in highly stressed calves.
abstract: One thousand and eighty-five newly received, stressed calves were used in studies to determine the effectiveness of certain mass medication procedures for reducing morbidity from shipping fever-bovine respiratory disease complex. In two experiments, im injections of oxytetracycline at 11 mg/kg body wt for 3 successive days reduced treatment days/calf purchased 21 (P less then .05) and 31% (P less than .05). Oral administration of 150 mg of sulfadimethoxine/kg body wt reduced treatment days/calf purchased 20 (P less than .05) and 54% (P less than .05) in the same two experiments. When sulfadimethoxine followed oxytetracycline on the third injection day an 81% reduction in treatment days/calf purchased was obtained, indicating an additive effect of the two drugs. The use of long acting oxytetracycline and sustained release sulfadimethoxine at the time of processing resulted in a 90% reduction in treatment days/calf purchased (P less than .01) and required only one handling of the calves for mass medication purposes.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002751:Chlortetracycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use; D010326:Pasteurella Infections / Q000188:drug therapy* / Q000662:veterinary*; D012766:Pasteurellosis, Pneumonic / Q000188:drug therapy*; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000662:veterinary*; D013412:Sulfadimethoxine / Q000627:therapeutic use; D014186:Transportation
chemical_list: D013412:Sulfadimethoxine; D002751:Chlortetracycline; D010118:Oxytetracycline