[Activation of the blood kallikrein-kinin system in disseminated intravascular coagulation in rats. The significance of the pulmonary component and an attempt at correction with aspirin].
It has been shown that the development in animals of disseminated intravascular coagulation (DIC) caused by long-term intravenous infusion of thrombin was accompanied by appreciable activation of the kallikrein-kinin system, being characteristic of acute pathological processes. In the initial stages of the process development, prekallikrein and kallikrein inhibitor were observed to be secreted from the lungs to arterial blood. Further development of DIC led to the depletion of the reserves of the kinin system. Pretreatment with a single low dose of acetylsalicylic acid considerably reduced the total animals' lethality and postponed blood kinin system activation determined by the development of DIC.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology; D000818:Animals; D000933:Antifibrinolytic Agents / Q000494:pharmacology; D001241:Aspirin / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000494:pharmacology; D062366:para-Aminobenzoates
D000933:Antifibrinolytic Agents; D007705:Kinins; D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D007610:Kallikreins; D013917:Thrombin; D001241:Aspirin; D010129:4-Aminobenzoic Acid
Aktivatsiia kallikrein-kininovoĭ sistemy krovi pri disseminirovannom vnutrisosudistom svertyvanii u krys. Znachenie legochnogo komponenta i popytka korrektsii aspirinom.