Colchicine in acute inflammation: stimulation of production of interleukin-1 and modulation of the acute phase serum amyloid A protein response.
The effects of colchicine on the acute phase serum amyloid A (SAA) response were studied in CBA/J mice to determine whether these effects are mediated via inhibition of interleukin-1 (IL-1) production. Prolonged pretreatment (72 h) with colchicine blunted the SAA response to stimulation with silver nitrate (AgNO3), while brief pretreatment (12 h) unexpected augmented SAA production. In a macrophage model, colchicine stimulated baseline production of IL-1 (SAA inducer and lymphocyte activating factor activities) and augmented lipopolysaccharide (LPS) induced IL-1 production. This indicates that colchicine does not inhibit amyloidosis via direct effects on early inducers of the acute phase SAA response.
D000682:Amyloid / Q000096:biosynthesis*; D000686:Amyloidosis / Q000276:immunology*; D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D005260:Female; D007249:Inflammation / Q000276:immunology*; D007375:Interleukin-1 / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D000685:Serum Amyloid A Protein / Q000096:biosynthesis*
D000682:Amyloid; D007375:Interleukin-1; D000685:Serum Amyloid A Protein; D003078:Colchicine