The renin-angiotensin-aldosterone system in Cushing's syndrome and pheochromocytoma.
We investigated the status of the renin-angiotensin-aldosterone axis in 5 patients with Cushing's syndrome and 7 patients with pheochromocytoma. In most of the patients with Cushing's syndrome no significant abnormalities of the renin-angiotensin-aldosterone system could be detected. In 4 out of 7 patients with pheochromocytoma, plasma renin activity remained high after saline suppression and decreased into the normal range in all 4 patients after removal of pheochromocytoma. These results imply that the postulated mineralocorticoid excess was not present in the patients with Cushing's syndrome studied. In pheochromocytoma, high levels of plasma catecholamines contribute to a high renin state which may have pathophysiologic implications.
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000503:physiopathology* / Q000601:surgery; D000328:Adult; D002395:Catecholamines / Q000652:urine; D003480:Cushing Syndrome / Q000503:physiopathology*; D005260:Female; D005665:Furosemide; D006801:Humans; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000503:physiopathology* / Q000601:surgery; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System
D002395:Catecholamines; D005665:Furosemide; D012083:Renin