[A new diagnostic test for primary tumoral hyperaldosteronism].
Plasma aldosterone levels were measured during two tests of inhibition in 31 hypertensive patients (13 essential hypertension, 6 bilateral adrenal hyperplasia and 12 documented Conn adenomas) on normal salt diets after withdrawal of all therapy: 1--before and after intravenous infusion of 2 I normal saline in two hours; 2--before and three hours after administration of 1 mg/kg of Captopril. Plasma aldosterone levels greater than 360 pmol/I after salt loading, or greater than 748 pmol/I after Captopril is characteristic of primary tumoral hyperaldosteronism. Apart from the rapidity of the test, Captopril is well-tolerated, does not require acute volume expansion and can be carried out in all forms of hypertension, even in severe cases.
D000236:Adenoma / Q000175:diagnosis*; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis*; D000311:Adrenal Glands / Q000473:pathology; D000328:Adult; D000450:Aldosterone / Q000097:blood; D002216:Captopril; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000175:diagnosis*; D006965:Hyperplasia / Q000150:complications; D006973:Hypertension / Q000209:etiology; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*
D000450:Aldosterone; D011392:Proline; D002216:Captopril
Un nouveau test diagnostique de l'hyperaldostéronisme primaire tumoral.