[Effect of a glucose-insulin-potassium mixture on the cyclic and adenine nucleotide levels in the acute period of myocardial infarct].
The development of myocardial infarction was shown to be accompanied by a rise in blood cAMP, cGMP and AMP levels, cyclic nucleotides peaking within the first hours of the disease. The increase in plasma cAMP, associated with developing heart failure, was more persistent. The administration of GIP mixture during the acute phase of myocardial infarction was conducive to lowering the levels of cyclic nucleotides and AMP, and raising blood ATP and ADP values. Clinically, the effect of GIP was manifested in reduced ventricular arrhythmias and diminished signs of heart failure.
D000227:Adenine Nucleotides / Q000097:blood*; D000328:Adult; D000368:Aged; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D009712:Nucleotides, Cyclic / Q000097:blood*; D011188:Potassium / Q000008:administration & dosage*; D013997:Time Factors
D000227:Adenine Nucleotides; D007328:Insulin; D009712:Nucleotides, Cyclic; D005947:Glucose; D011188:Potassium
Vliianie gluikozo-insulino-kalievoĭ smesi na uroven' tsiklicheskikh i adenilovykh nukleotidov u bol'nykh v ostrom periode infarkta miokarda.