title: Cardiovascular and platelet effects in man of BW 245C, a stable mimic of epoprostenol (PGI2).
abstract: 1 BW 245C is a stable hydantoin prostaglandin analogue with a biological action similar to epoprostenol (PGI2). 2 Intravenous BW 245C (1,2 and 4 ng kg-1 min-1) produced a progressive increase in heart rate and pulse pressure in four healthy male volunteers. 3 These changes in heart rate and pulse pressure were accompanied by reduced ex vivo platelet aggregation to submaximal concentrations of ADP. 4 In man, BW 245C has a profile of action and potency similar to PGI2. However, it has a longer duration of action than PGI2.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D011464:Epoprostenol / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006827:Hydantoins / Q000494:pharmacology*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D006827:Hydantoins; D011453:Prostaglandins; D000244:Adenosine Diphosphate; C030669:BW 245C; D011464:Epoprostenol