Alternative explanation for excision repair deficiency caused by the polAex1 mutation.
An investigation of the mechanism of the polAex1 mutation in vitro suggested that the excision repair deficiency observed in vivo does not result from an inability of the enzyme to nick translate. The defect appears to reside in the inability of the enzyme to effectively generate a nick structure to serve as a substrate for DNA ligase.
D011088:DNA Ligases / Q000378:metabolism; D004260:DNA Repair; D004926:Escherichia coli / Q000235:genetics*; D009154:Mutation
D011088:DNA Ligases