[Effect of cadmium, zinc, lead and mercury on the enzyme activity in Saccharomyces cerevisiae in vitro].
The difference between cadmium, zinc, lead, and mercury in regard of their effects on the activity of the enzymes tested is very slight. Concentrations higher than 10(-5) M reduce significantly the activity of the enzymes, and concentrations of approximately 10(-3) M inhibit it completely. An increase of the activity cannot be detected. The addition of combinations of cadmium, zinc, and lead results in a summing up of the toxic effects, whereas the interaction between mercury and the other three heavy metals shows a cumulative effect, which is appointed nearly completely by the heavy metal more toxic. The findings suggest that under in-vitro conditions there exists a direct interaction between the heavy metals and the enzymes.
D002104:Cadmium / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism*; D007854:Lead / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008628:Mercury / Q000008:administration & dosage; D008670:Metals / Q000008:administration & dosage*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D015032:Zinc / Q000008:administration & dosage
D008670:Metals; D002104:Cadmium; D007854:Lead; D008291:Malate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D005969:Glutamate Dehydrogenase; D008628:Mercury; D015032:Zinc
Der Einfluss von Cadmium, Zink, Blei und Quecksilber auf die Enzymaktivität bei Saccharomyces cerevisiae in vitro.