title: [Ventilation scintigraphy of the lung with 99mTc-DTPA or with 99mTc-sulfur colloid?].
abstract: Ventilation scintigraphy of the lung, obtained with sufficiently small 99mTc-labelled aerosol particles, provides an image of ventilation distribution that is acceptable in clinical routine. Whether 99mTc-DTPA or 99mTc-sulfur colloid is more suitable as a carrier was studied in 6 smokers and 8 non-smokers with chronic obstructive pulmonary disease. 99mTc-sulfur colloid was not absorbed by the bronchial mucosa and therefore appears to be an almost ideal agent. In contrast, 99mTc-DTPA was absorbed by the bronchial mucosa in all smoking patients more rapidly and inhomogenously than in non-smokers. The quantitative and qualitative comparison of the two dorsal ventilation scans taken both immediately after inhalation and 20 min later, showed in all 6 smoking patients after 20 min significant differences which influenced the diagnosis result. 99mTC-DTPA is therefore not recommended for use in ventilation lung scintigraphy, especially in smoking patients.
mesh_terms: D000293:Adolescent; D000336:Aerosols; D000368:Aged; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid / Q000008:administration & dosage*; D011877:Radionuclide Imaging; D012907:Smoking; D013455:Sulfur / Q000008:administration & dosage*; D013667:Technetium / Q000008:administration & dosage*; D016284:Technetium Tc 99m Pentetate; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D000336:Aerosols; D013671:Technetium Tc 99m Sulfur Colloid; D013455:Sulfur; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate
vernacular_title: Ventilationsszintigraphie der Lunge mit 99mTc-DTPA oder mit 99mTc-Schwefelkolloid?