The mid-term effects of radiotherapy on T and B lymphocytes: an evaluation of cellular immunity with standard methods and monoclonal antibodies.
The mid-term effects of radiotherapy on T and B peripheral lymphocytes of 15 patients treated for various malignancies were evaluated. All patients had a significant impairment of lymphocyte functions, as measured by blastogenesis after stimulation with phytohemagglutinin and pokeweed mitogen. Such impairment lasted for 1 year after the completion of radiotherapy, when numerical variability of T and B subpopulations, observed during and after radiation treatment, was restored to initial values.
D001402:B-Lymphocytes / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000528:radiation effects; D007111:Immunity, Cellular / Q000528:radiation effects*; D008213:Lymphocyte Activation / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000528:radiation effects*
D011947:Receptors, Antigen, B-Cell