[Combined antibacterial activity of clavulanic acid with amoxicillin and ampicillin against Gram-negative strains].
Clavulanic acid was tested for in vitro synergistic activity with Ampicillin and Amoxycillin against 41 Gram-negative strains beta-lactamase positive or negative. Clavulanic acid provides progressive inhibition of the beta-lactamases of many bacteria. The better protective effect of CA on AM or AMX is at concentration of 100 mcg. Some synergy was seen against E. coli, Klebsiella and Proteus. Enterobacter and Pseudomonas remained resistant to the combination of AMX and AM with clavulanic acid. We have seen no synergistic effect when non beta-lactamase producing organisms were tested. Although CA alone has a broad antibacterial spectrum, the degree of activity is generally rather poor.
D000658:Amoxicillin / Q000494:pharmacology*; D000667:Ampicillin / Q000494:pharmacology*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004347:Drug Interactions; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology; D011549:Pseudomonas / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis
D002969:Clavulanic Acids; D019818:Clavulanic Acid; D000667:Ampicillin; D000658:Amoxicillin; D001618:beta-Lactamases
Attività antibatterica combinata dell'acido clavulanico con amoxicillina e ampicillina nei confronti di ceppi Gram-negativi.