[Participation of cyclic nucleotides in realizing the effect of ceruloplasmin during irradiation].
It was shown that a single intraperitoneal administration of human ceruloplasmin 60 min before irradiation (4.22, 5.28 and 7.20 Gy) increases the content of cyclic AMP and cyclic GMP in the thymus and spleen of rats 3 and 6 h following X-irradiation. Ceruloplasmin increases the cyclic AMP/cyclic GMP ratio in the above-mentioned rat organs in normal conditions and on radiation pathology.
D000818:Animals; D002570:Ceruloplasmin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000096:biosynthesis* / Q000502:physiology; D006152:Cyclic GMP / Q000096:biosynthesis* / Q000502:physiology; D008297:Male; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013268:Stimulation, Chemical; D013950:Thymus Gland / Q000378:metabolism
D011837:Radiation-Protective Agents; D000242:Cyclic AMP; D002570:Ceruloplasmin; D006152:Cyclic GMP
Uchastie tsiklicheskikh nukleotidov v realizatsii deĭstviia tseruloplazmina pri obluchenii.