Intestinal K99+ escherichia coli adhesion and absorption of colostral IgG1 in the newborn lamb: effect of fetal infusion of thyroid hormones.
Continuous infusion of thyroid hormones during the last 12 days of gestation in ovine fetuses was associated with: a reduction of the rate of appearance of blood IgG1 after colostrum feeding in the newborn lambs; an important reduction of the number of jejunal cells filled with IgG1, 12 hours post partum, suggesting a premature closure of the intestinal permeability to IgG1; and a significant reduction of the K99+ Escherichia coli adhesion on the intestinal villi. These results could partly explain relationships observed previously between perinatal thyroid function abnormalities and the occurrence of neonatal diseases.
D000268:Adhesiveness; D000818:Animals; D000831:Animals, Newborn; D003126:Colostrum / Q000276:immunology*; D004926:Escherichia coli / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects; D007074:Immunoglobulin G / Q000378:metabolism*; D007263:Infusions, Parenteral / Q000662:veterinary; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000382:microbiology*; D011247:Pregnancy; D012756:Sheep / Q000276:immunology*; D013974:Thyroxine / Q000008:administration & dosage / Q000494:pharmacology*; D014284:Triiodothyronine / Q000008:administration & dosage / Q000494:pharmacology*
D007074:Immunoglobulin G; D014284:Triiodothyronine; D013974:Thyroxine