Unusual T cell proliferations and neutropenia in rheumatoid arthritis: comparison with classical Felty's syndrome.
4 patients are described with rheumatoid arthritis, splenomegaly, neutropenia and an unusual proliferation of T cells in the blood and marrow. These patients are clinically similar to patients with classical Felty's syndrome but can be distinguished from them by staining blood and marrow mononuclear cells with a panel of monoclonal anti-T cell antibodies. The T cells from patients with T cell proliferations stain with UCHT1 (OKT3 equivalent) and UCHT4 (OKT8 equivalent but do not stain with a panel of OKT1-like antibodies. In 7 patients with classical Felty's syndrome there was no increase of UCHT4 cells in the blood and the large majority of T cells stained with OKT1-like antibodies. The marrows from the patients with T cell proliferations contain plentiful haemopoietic progenitor cells and it is probable that the T lymphocytes suppress their normal maturation. There was a poor response to splenectomy in 2 patients with T cell proliferations, and single cytotoxic drug therapy may be more appropriate when therapy is required. The literature is reviewed and it is suggested that the T cell proliferations may be secondary to the rheumatoid process.
D000328:Adult; D000380:Agranulocytosis / Q000209:etiology*; D000906:Antibodies / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000097:blood*; D002455:Cell Division; D005258:Felty Syndrome / Q000097:blood*; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology*; D010641:Phenotype; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*
D000906:Antibodies