Interactions of analgesics with other drugs.
Antipyretic analgesics, such as salicylates, acetaminophen, and pyrazolones, are often given concomitantly with a variety of other drugs. Drug interactions that occur at the receptors are known as pharmacodynamic interactions; alterations in absorption (bioavailability), distribution (plasma protein-binding), and elimination (renal excretion, hepatic metabolism) are termed pharmacokinetic interactions. For example, antacids and food both delay the absorption of analgesics. Highly protein-bound drugs (such as phenylbutazone, phenytoin, or warfarin) can compete with the common binding sites of salicylates. Hepatic elimination of salicylates can be influenced by drugs such as beta-blockers and cimetidine. Clinically important interactions involving salicylates, acetaminophen, and other antipyretic analgesics are discussed.
D000082:Acetaminophen / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000378:metabolism; D000925:Anticoagulants / Q000009:adverse effects; D001798:Blood Proteins / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000009:adverse effects; D007408:Intestinal Absorption / Q000187:drug effects; D008727:Methotrexate / Q000009:adverse effects; D011485:Protein Binding / Q000187:drug effects; D012459:Salicylates / Q000009:adverse effects; D013453:Sulfonylurea Compounds / Q000009:adverse effects; D014528:Uricosuric Agents / Q000037:antagonists & inhibitors; D014556:Urine / Q000187:drug effects
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D001798:Blood Proteins; D007004:Hypoglycemic Agents; D012459:Salicylates; D013453:Sulfonylurea Compounds; D014528:Uricosuric Agents; D000082:Acetaminophen; D008727:Methotrexate