Immunomorphologic classification of spontaneous lymphoid cell neoplasms occurring in female BALB/c mice.
WIth the use of a recently proposed, combined immunomorphologic classification (Pattengale-Taylor, 1981) for murine lymphomas and related leukemias, 70 spontaneously occurring lymphoid cell neoplasms from female BALB/cStCrl mice were evaluated and classified and then compared to the earlier Dunn classification (Dunn, 1954). The predominant lesion (i.e., 60% total incidence) in female BALB/c mice [previously called "reticulum cell sarcomas (neoplasm)", type B, by Dunn] was a lymphoid cell neoplasm derived from follicular center cells (i.e., follicular center cell [FCC] lymphoma). The B-cell nature was further confirmed in the majority (76%) of these FCC lymphomas by means of immunoperoxidase techniques that demonstrated the presence of cytoplasmic immunoglobulin (Clg). Smaller percentages of B-lymphoblastic (10% total incidence) and B-immunoblastic (7% total incidence) lymphomas were also observed. In addition, FCC, B-lymphoblastic, and B-immunoblastic lymphomas occurred in female BALB/c mice over 20 months of age. In contrast, Clg-negative lymphoblastic lymphomas involving the anterior mediastinum (and presumably T-cell in origin) occurred with a bimodal incidence in both young (13% total incidence at a mean age less than 6 mo) and old (10% total incidence at a mean age greater than 21 mo) female mice.
D000818:Animals; D005260:Female; D007124:Immunoenzyme Techniques; D007942:Leukemia, Experimental / Q000145:classification / Q000276:immunology / Q000473:pathology*; D008223:Lymphoma / Q000145:classification / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000145:classification / Q000276:immunology / Q000473:pathology