[Modification of the development of infant kidneys by homotransplantation to adult recipients. Hemodynamic and morphologic study on the minipig].
To study the development or absence of a compensatory hypertrophy and early maturity of suckling kidneys after allotransplantation into adult recipients, MLC histocompatible piglet kidneys of the minipig were transplanted en bloc into the binephrectomized mother. As a result, the significant higher renal perfusion pressure in the circulation of the sow in comparison with the lower arterial pressure in the piglet organism caused a autoregulatoric increase in the blood flow of the infantile kidneys following the transplantation. After 1-2 weeks, the transplants showed an abnormal weight increase attributable to the prematurity associated with glomerular and tubular hypertrophy as well as to rejection-induced or unspecific inflammatory infiltrations. The functional effectiveness of the pediatric grafts were limited especially by the body weight of the recipients and by the rapidly occurring deficit of nephrons in consequence of infection and/or rejection. As a survival period of 45 days was reached in one case, the recipient shows approximately physiological creatinine concentrations in serum.
D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection; D006439:Hemodynamics; D006984:Hypertrophy; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation; D009929:Organ Size; D012079:Renal Circulation; D013552:Swine; D013556:Swine, Miniature
D003404:Creatinine
Beeinflussung der Entwicklung von Säuglingsnieren durch Homotransplantation auf adulte Rezipienten. Hämodynamische und morphologische Studie am Minischwein.