Direct immunofluorescence in pyoderma gangrenosum.
Direct immunofluorescence was done in fifty-one cases of pyoderma gangrenosum. Biopsy specimens were taken from the peripheral erythematous zone of the lesion. In thirty-one cases (61%), there was positive immunofluorescence, with perivascular deposition of immune reactants being the most frequent pattern (twenty-seven cases). These findings support a vasculitic pathogenesis of pyoderma gangrenosum.
D005455:Fluorescent Antibody Technique; D006801:Humans; D011711:Pyoderma / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology; D012883:Skin Ulcer / Q000276:immunology* / Q000473:pathology