title: The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study.
abstract: In a double-blind, randomized dose-response study, 75 women with benign breast disease were administered a written questionnaire in which they scored the severity of premenstrual syndrome (PMS) symptoms before and after two months of treatment with placebo or alpha-tocopherol (150, 300, or 600 IU/day). Controlling for age and pretreatment scores, alpha-tocopherol had a significantly greater effect than placebo, improving three of the four classes of PMS symptoms. These findings suggest that vitamin E supplementation may be of value in women with severe PMS symptoms.
mesh_terms: D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008599:Menstruation Disturbances / Q000188:drug therapy*; D008875:Middle Aged; D011293:Premenstrual Syndrome / Q000188:drug therapy; D013577:Syndrome; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D014810:Vitamin E