Effectiveness of praziquantel against the South African strains of Schistosoma haematobium and S. mansoni.
A total of 137 Black children from two schools in Natal, infected with either Schistosoma haematobium or S. mansoni, or both, were treated with praziquantel (Biltricide; Bayer-Miles) at a dosage of 40 mg/kg body weight. Dramatic reductions in egg output occurred within a matter of days and high cure rates (greater than or equal to 97%) were obtained in both S. haematobium and S. mansoni infections. Side-effects were of short duration and not serious.
D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D005243:Feces / Q000469:parasitology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D010270:Parasite Egg Count; D011223:Praziquantel / Q000627:therapeutic use*; D012548:Schistosoma haematobium / Q000302:isolation & purification; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012552:Schistosomiasis / Q000188:drug therapy*; D013997:Time Factors; D014556:Urine / Q000469:parasitology
D007546:Isoquinolines; D011223:Praziquantel