Mutagenesis of nitro-dibenzo-p-dioxins.
Two dioxins, 2-nitro-dibenzo-p-dioxin (I) and 2,3 dichloro-7-nitro-dibenzo-p-dioxin (II), were prepared by condensing 3,4 dichloro nitrobenzene with the dipotassium salts of catechol and 4,5-dichloro-catechol, respectively. Both compounds were very mutagenic for Salmonella typhimurium TA1538, but only weakly mutagenic for TA1537. Compound II, but not compound I, also induced a few (approximately 100 revertants at near toxic doses) point mutations in strain TA1535.
D004269:DNA, Bacterial / Q000096:biosynthesis; D004147:Dioxins / Q000633:toxicity*; D005798:Genes, Bacterial / Q000187:drug effects; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics
D004269:DNA, Bacterial; D004147:Dioxins; D009153:Mutagens; C038125:2-nitrodibenzo-4-dioxin; C038124:2,3-dichloro-7-nitrodibenzo-4-dioxin