[Intracellular and extracellular proteins binding androgenic hormones. Biochemical properties and clinical significance].
This paper has been designed to review some current concepts about biochemistry, pathophysiology and clinics of androgen-binding proteins, both TeBG and cellular receptors. Some important experimental models to clarify the interactions between androgens and target cells are mentioned. Further, major clinical applications in which binding parameters were or will be of great importance are discussed in details.
D015065:17-Hydroxycorticosteroids / Q000378:metabolism; D015068:17-Ketosteroids / Q000378:metabolism; D000727:Androgen-Binding Protein / Q000378:metabolism* / Q000502:physiology; D013734:Androgen-Insensitivity Syndrome / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D003613:Danazol / Q000494:pharmacology; D012734:Disorders of Sex Development / Q000378:metabolism; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism; D007248:Infertility, Male / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008297:Male; D008914:Minoxidil / Q000494:pharmacology; D011944:Receptors, Androgen / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D012738:Sex Hormone-Binding Globulin / Q000097:blood / Q000378:metabolism / Q000502:physiology; D013148:Spironolactone / Q000494:pharmacology
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000727:Androgen-Binding Protein; D002352:Carrier Proteins; D011944:Receptors, Androgen; D012738:Sex Hormone-Binding Globulin; D013148:Spironolactone; D008914:Minoxidil; D003613:Danazol
Le proteine intracellulari ed extracellulari leganti gli ormoni androgeni. Proprietà biochimiche e rilevanza clinica.