title: Moxalactam versus cefazolin prophylaxis for vaginal hysterectomy.
abstract: Moxalactam is a newer beta-lactam antibiotic with increased activity and an extended antimicrobial spectrum. Three 1 gm doses were given to women scheduled for elective vaginal hysterectomy. This perioperative regimen was prospectively compared to identical doses of cefazolin, a first-generation cephalosporin of proved efficacy. The overall incidence of major postoperative infection in 193 women was less than 5% and there were no significant interregimen differences. The incidence of major infection was directly related to the type of procedure performed.
mesh_terms: D000290:Adnexa Uteri / Q000382:microbiology; D000328:Adult; D002437:Cefazolin / Q000627:therapeutic use*; D002481:Cellulitis / Q000517:prevention & control; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007045:Hysterectomy, Vaginal; D009070:Moxalactam / Q000627:therapeutic use*; D000292:Pelvic Inflammatory Disease / Q000517:prevention & control; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D014621:Vagina / Q000382:microbiology
chemical_list: D002437:Cefazolin; D009070:Moxalactam