Bone marrow transplantation for Niemann-Pick mice.
The Niemann-Pick mice which received bone marrow transplants showed a decreased accumulation of sphingomyelin and cholesterol quantitatively in their spleen. The sphingomyelin deposit in the bone marrow was also reduced histochemically. However, the neurological manifestations were not improved by the bone marrow graft.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D016026:Bone Marrow Transplantation; D002784:Cholesterol / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009542:Niemann-Pick Diseases / Q000378:metabolism / Q000628:therapy*; D013109:Sphingomyelins / Q000378:metabolism; D013154:Spleen / Q000378:metabolism
D013109:Sphingomyelins; D002784:Cholesterol