Inhibition of gastric acid secretion by intracerebroventricularly administered prostaglandin e2 in anaesthetized rats.
1 The effect of intracerebroventricularly (i.c.v) administered prostaglandin E2 (PGE2) on gastric acid secretion was studied in anaesthetized rats. 2 Intracerebroventricular injections of 1 and 3 micrograms of PGE2 inhibited gastric acid secretion induced by insulin, electrical vagal stimulation and acetylcholine in a dose-dependent manner. 3 Intravenous injections of 1,3 and 10 micrograms of PGE2 had no effect on insulin-stimulated gastric acid output. 4 The results indicate that upon i.c.v. administration PGE2 inhibits gastric acid secretion by acting centrally and not peripherally after leakage from the central nervous system.
D000109:Acetylcholine / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D015232:Dinoprostone; D004558:Electric Stimulation; D005744:Gastric Acid / Q000378:metabolism*; D007276:Injections, Intraventricular; D007328:Insulin / Q000494:pharmacology; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000502:physiology
D007328:Insulin; D011458:Prostaglandins E; D015232:Dinoprostone; D000109:Acetylcholine