The metabolic fate of double-labeled disulfiram.
The metabolic fate of disulfiram labeled with both 14C and 35S was studied in the rat. After administration of 50 mg of 14C, 35S-disulfiram dissolved in corn oil to rats by stomach tube, 95% of the radioactivity was recovered in urine, feces, and expired air at 144 hr. The major portion of the excreted radioactivity was in urine (75 +/- 6%). Feces and expired air contained 13 +/- 2% and 6 +/- 5% of the body organs or carcass. Pretreatment of rats with unlabeled disulfiram for 20 days prior to administration of 14C, 35S-disulfiram led to more rapid catabolism of the drug and more rapid excretion of radioactivity in the urine during the first 12 hr after dosing.
D000818:Animals; D001711:Biotransformation; D004048:Diethylamines / Q000652:urine; D004221:Disulfiram / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D007700:Kinetics; D008297:Male; D051381:Rats
D004048:Diethylamines; C034281:diethylamine; D004221:Disulfiram