[Modulating action of interferon preparations on cellular reactions of antitumor immunity].
The study established an immunomodulating effect of preparations of human leukocytic interferon in spontaneous rosette-formation test (E--RFC) and leukocyte adherence inhibition reaction (LAI) which takes place both in healthy donors and patients with cervical carcinoma. In E--RFC test, administration of interferon preparations caused the E-rosette forming cell fraction to increase in donors. A similar but much lower effect was observed in the patient group. The effect of interferon produced by patients leukocytes was low. In LAI test, interferon treatment eliminated tumor antigen-induced inhibition in cases of cell-mediated immunity. However, it failed to materially affect the fraction of adhering cells in cases of negative reaction.
D000951:Antigens, Neoplasm / Q000276:immunology; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D007957:Leukocyte Adherence Inhibition Test; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
D000951:Antigens, Neoplasm; D007370:Interferon Type I
O moduliruiushchem deĭstvii preparatov interferona na kletochnye reaktsii protivoopukholevogo immuniteta.