Effects of exogenous inactive renin on blood pressure and adrenal secretion of aldosterone and cortisol in the canine puppy.
To determine whether plasma inactive renin, M.W. 56,000, has an effect on blood pressure, renal function, and adrenal hormones in the newborn, one microgram of purified human plasma inactive renin was infused in ten canine puppies. After 30 minutes, mean aortic blood pressure increased 9 mm Hg (p less than .02), and plasma renin activity (PRA) increased from 22 to 64 mg/ml/hr (p less than .001). Plasma cortisol increased from 3 to 9 microgram/dl after 60 minutes (p less than .05). There was an increase in sodium and potassium excretion (p less than .05), without a change in glomerular filtration rate. This data suggests that human exogenous plasma inactive renin. M.W. 56,000 may have a physiological function in the canine puppy.
D000311:Adrenal Glands / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D006854:Hydrocortisone / Q000378:metabolism*; D012083:Renin / Q000494:pharmacology*
D000450:Aldosterone; D012083:Renin; D006854:Hydrocortisone