Association of HLA-DR7 with both antibody to SSA(Ro) and disease susceptibility in blacks with systemic lupus erythematosus.
The relationship between HLA-DR antigens and various specific antinuclear antibodies was studied in 28 unselected black Americans with systemic lupus erythematosus (SLE). Anti-SSA(Ro) occurred with high frequency (61%) but was not associated with specific clinical features of SLE. HLA-DR7 was strongly associated with anti-SSA antibody; it was present in 13/17 patients with anti-SSA (76%) and 1/11 patients without it (9%). HLA-DR7 occurred in 14/28 of all SLE patients (50%) compared with 17% of 137 local controls (p corrected, less than 0.005). This association of HLA-DR7 with both susceptibility to SLE and a high frequency of anti-SSA antibody suggests a genetic link between the presence of anti-SSA antibody and susceptibility to SLE in the population studied.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D000941:Antigens / Q000276:immunology*; D001324:Autoantigens; D044383:Black People; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006684:HLA-DR Antigens; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D012306:Risk; D001741:Black or African American; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D000941:Antigens; D001324:Autoantigens; D005819:Genetic Markers; D006684:HLA-DR Antigens; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies