The eye in bone marrow transplantation. I. Clinical study.
A prospective study of 45 patients undergoing bone marrow transplantation included full ocular examination and pretransplant and posttransplant conjunctival biopsies. The major finding was the development of a severe keratoconjunctivitis sicca syndrome that developed in 20 of the 45 patients and closely correlated with the occurrence of acute graft-v-host disease (GVHD). An acute pseudomembranous conjunctivitis in the fulminant stage of acute GVHD developed in six patients. A further ten patients made up a retrospective assessment of bone marrow transplantation and confirmed these clinical findings.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D006087:Graft vs Host Reaction; D006801:Humans; D007637:Keratoconjunctivitis / Q000209:etiology*; D007938:Leukemia / Q000628:therapy; D008297:Male; D011183:Postoperative Complications; D011446:Prospective Studies