A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites.
BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani.
D000818:Animals; D003433:Crosses, Genetic; D005796:Genes; D007113:Immunity, Innate; D007898:Leishmaniasis, Visceral / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D009163:Mycobacterium bovis; D012481:Salmonella Infections, Animal / Q000235:genetics* / Q000276:immunology; D012486:Salmonella typhimurium; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology