Certain mouse strains are deficient in a kidney brush-border metallo-endopeptidase activity.
Preparations of microvilli from kidneys of BALB/c mice contain an alkaline metallo-endopeptidase, meprin (metallo-endopeptidase from renal tissue). Certain genealogically related inbred mice are markedly deficient in meprin activity. The meprin-deficient strains (CBA/J and C3H/HeJ) exhibit normal levels of other brush-border enzymes: alkaline phosphatase, aminopeptidase M and another proteinase, a phosphoramidon-sensitive neutral endopeptidase. Meprin deficiency cannot be attributed to a shift in pH optimum and is unlikely to be due to the presence of endogenous inhibitors.
D000818:Animals; D010450:Endopeptidases / Q000172:deficiency*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D008666:Metalloendopeptidases; D051379:Mice; D008807:Mice, Inbred BALB C / Q000378:metabolism; D008809:Mice, Inbred C3H / Q000378:metabolism; D008808:Mice, Inbred CBA / Q000378:metabolism; D008815:Mice, Inbred Strains / Q000378:metabolism*; D008871:Microvilli / Q000201:enzymology; D010447:Peptide Hydrolases / Q000378:metabolism
D010450:Endopeptidases; D010447:Peptide Hydrolases; D008666:Metalloendopeptidases