title: [Prevention of preoperative infection with metronidazole].
abstract: We practiced a preoperative prophylaxis with 1.5g metronidazole daily starting three days before operation because of the increasing knowledge about the importance of anaerobic microorganisms, causing nosocomial infections. By this regime we saw a significant decrease of postoperative morbidity, detected by means of postoperative febrile temperatures and laparotomy wound abscesses. Bacteriological examinations before and after prophylaxis revealed a relatively high elimination of anaerobic isolates without influence on the aerobic and physiologic flora. In 66% of the cases with infections we isolate anaerobic strains. In cases of pelvic inflammatory diseases metronidazole is to be recommended both prophylactically and therapeutically. There is no resistance against metronidazole.
mesh_terms: D000038:Abscess / Q000382:microbiology / Q000517:prevention & control; D001431:Bacteriological Techniques; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D011247:Pregnancy; D011292:Premedication; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*; D014621:Vagina / Q000382:microbiology
chemical_list: D008795:Metronidazole
vernacular_title: Präoperative Infektionsprophylaxe mit Metronidazol.