Inhibitory effect of prostacyclin (PGI2) on neutropenia induced by intravenous injection of platelet-activating-factor (PAF) in the rabbit.
Intravenous injection into rabbits of 1-O-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (synthetic Platelet-Activating Factor (PAF)) or PAF derived from rabbit basophils caused acute thrombocytopenia and neutropenia which was consequent to the formation of intravascular polymorphonuclear neutrophil (PMN) aggregates and to their sequestration in the microvasculature, primarily of the lung. Infusion of prostacyclin (PGI2; 10 ng/Kg/min to 50 ng/Kg/min) inhibited in a dose-dependent manner PAF-induced thrombocytopenia and neutropenia as well as the sequestration of PMN in the pulmonary capillary network.
D000380:Agranulocytosis / Q000139:chemically induced*; D000818:Animals; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008297:Male; D009503:Neutropenia / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D010972:Platelet Activating Factor / Q000633:toxicity*; D011453:Prostaglandins / Q000494:pharmacology*; D011817:Rabbits
D010972:Platelet Activating Factor; D011453:Prostaglandins; D011464:Epoprostenol