title: Ferritin (FER) in testicular germ cell tumours. An immunohistochemical study.
abstract: 189 orchidectomy specimens with germ cell tumours were studied for the presence of ferritin (FER) using the indirect immunoperoxidase technique. FER was demonstrated in 93% of seminomas and 90% of non-seminomas. Various epithelial cell types in embryonal carcinoma (EC), yolk sac tumours (YST) and teratoma (T) were FER positive. Carcinoma-in-situ (CIS) which was present in the seminiferous tubules adjacent to the tumours was positively stained for FER in 94% of the specimens whether the tumour was a seminoma or a non-seminoma indicating a functional relationship of CIS to seminomatous as well as to non-seminomatous germ cell tumours.
mesh_terms: D002278:Carcinoma in Situ / Q000032:analysis; D004407:Dysgerminoma / Q000032:analysis; D005293:Ferritins / Q000032:analysis*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008649:Mesonephroma / Q000032:analysis; D013724:Teratoma / Q000032:analysis; D013736:Testicular Neoplasms / Q000032:analysis*
chemical_list: D005293:Ferritins