[Possibilities and value of immunofluorescence in the diagnosis of liver diseases].
The immunohistological investigation of liver tissue is at present regarded as method of choice for the differential diagnosis of the virus hepatitis. The quantity and distribution of various viral antigens of the hepatitis A, B and non-A/non-B furthermore allow statements concerning the prognosis. Moreover, they authoritatively influence etiopathogenetical and therapeutical concepts, also on account of the probably simultaneous proof of immunoglobulins and complement components. With the help of immunohistological methods also metabolic diseases (e.g. an alpha 1-antitrypsin deficiency) may clearly be diagnosed, when a diagnosis from the serum is not possible (among other post mortem). As an instance for scientific investigations the proof of complement in inclusion bodies of the liver cell and in so-called biliary thrombi are mentioned. Possibly in future the immunohistology is also mentioned for the early diagnosis of liver tumours.
D000914:Antibodies, Viral / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D006505:Hepatitis / Q000175:diagnosis; D006509:Hepatitis B / Q000175:diagnosis; D006525:Hepatitis, Viral, Human / Q000175:diagnosis; D006801:Humans; D007165:Immunosuppression Therapy; D007680:Kidney Neoplasms / Q000175:diagnosis; D008107:Liver Diseases / Q000175:diagnosis*; D011379:Prognosis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000914:Antibodies, Viral; D002272:Carcinoembryonic Antigen; D000515:alpha 1-Antitrypsin
Möglichkeiten und Stellenwert der Immunfluoreszenz in der Diagnostik von Leberkrankheiten.