title: Antimicrobial therapy of travellers' diarrhoea.
abstract: Two trials were carried out to evaluate antimicrobial agents in the therapy of travellers' diarrhoea. In the first, 72 students were given 500 mg bicozamycin (BI), a poorly absorbable drug, q.i.d. for three days and 68 were given a placebo. In the second, 37 students were given trimethoprim/sulphamethoxazole (160 mg TMP-SMX 800 mg), 38 TMP (200 mg), and in 35 a placebo was given b.i.d. for five days. Diarrhoea lasted on average 28 hours in those receiving BI compared to 64 hours in the placebo group (p = 0.00009). Significant shortening of diarrhoea after taking BI was seen for all subjects with illness, as well as those with ETEC diarrhoea, shigellosis and for those with unknown causes of illness. A significant clinical response was also noted in all categories of diarrhoea for both TMP-SMX and TMP when compared to placebo group.
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004405:Dysentery, Bacillary / Q000188:drug therapy*; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014195:Travel; D014295:Trimethoprim / Q000008:administration & dosage
chemical_list: D000890:Anti-Infective Agents; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D014295:Trimethoprim; C024504:bicozamycin; D013420:Sulfamethoxazole