Regulation of steroid-transforming enzymes by endogenous steroids.
The biosynthesis of C21, C19, and C18 steroids in adrenal, ovary, testis and foeto-placental unit is summarized and the properties of the enzymes involved are described, with particular reference to their substrate specificities and to the possible controlling effects of endogenous steroids. It is concluded that these may exert a considerable regulatory role in vivo in steroid hormone biosynthesis.
D000302:Adrenal Cortex / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D005260:Female; D005333:Fetus / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D008297:Male; D010053:Ovary / Q000201:enzymology / Q000378:metabolism; D010088:Oxidoreductases / Q000302:isolation & purification; D010920:Placenta / Q000201:enzymology / Q000378:metabolism; D011247:Pregnancy; D013250:Steroid Hydroxylases / Q000302:isolation & purification; D013251:Steroid Isomerases / Q000302:isolation & purification; D013256:Steroids / Q000096:biosynthesis / Q000502:physiology*; D013379:Substrate Specificity; D013737:Testis / Q000201:enzymology / Q000378:metabolism
D013256:Steroids; D010088:Oxidoreductases; D013250:Steroid Hydroxylases; D013251:Steroid Isomerases