[Activity of monocytes of subjects sensitized to Plasmodium falciparum: adherence and phagocytosis of merozoites in vitro. Role of cytophylic antibodies].
Peripheral blood monocytes from subjects immune to malaria are able to ingest more efficiently P. falciparum merozoites under in vitro conditions than those from non-immune subjects. Similar results were recorded when using monocytes from healthy controls preincubated with sera from immune individuals or IgG prepared from these sera. The phagocytic process does not seem to be strain specific. In the conditions of our assay, no phagocytosis of parasitized erythrocytes was observed. The main target of the IgG armed monocyte is the merozoite.
D000328:Adult; D000906:Antibodies / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008288:Malaria / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D010587:Phagocytosis; D010963:Plasmodium falciparum / Q000276:immunology*; D012397:Rosette Formation
D000906:Antibodies; D007074:Immunoglobulin G
Activité des monocytes de sujets sensibilisés vis-a-vis de Plasmodium falciparum: adhérence et phagocytose des mérozoites in vitro. Role des anticorps cytophiles.