Changes in brain angiotensinogen during development of hypertension.
Angiotensinogen was measured in the brain and cerebrospinal fluid (CSF) of spontaneously hypertensive rat (SHR) and the normotensive Wistar-Kyoto strain at 4, 7 and 16 weeks of age. Levels of angiotensinogen were elevated in a number of areas of SHR, primarily in the 4 and 7 week old animals. CSF levels did not correlate with the brain levels. These results suggest that the regulation of the brain angiotensin system maybe altered during the development of hypertension.
D000808:Angiotensinogen / Q000378:metabolism*; D000809:Angiotensins / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism*; D006651:Histocytochemistry; D006973:Hypertension / Q000378:metabolism*; D007120:Immunochemistry; D007124:Immunoenzyme Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000809:Angiotensins; D000808:Angiotensinogen