The radioenhancement effects of 5-thio-D-glucose and insulin in vivo on a hypoxic P388 murine leukemia.
A radioresistant in vivo tumor consisting of a partially hypoxic P388 murine leukemia growing intraperitoneally (IP) in B6D2F1 female mice was used to test the radioenhancement potential of 5-Thio-D-Glucose (5TDG) and insulin. Pretreated animals were exposed to increasing doses of whole body radiation (5, 10, 20 Gy) and harvested tumor cells were re-injected into new hosts. In this experiment little benefit was demonstrated with 5TDG or the combination of 5TDG and insulin + radiation. The median survival of animals receiving cells pre-treated with insulin and radiation was improved, but, in general, did not reach statistical significance by the log rank method.
D000818:Animals; D005260:Female; D005947:Glucose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000532:radiotherapy*; D051379:Mice; D009368:Neoplasm Transplantation; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
D007328:Insulin; D011838:Radiation-Sensitizing Agents; C003002:5-thio-D-glucose; D005947:Glucose