Malaria parasites adopt host cell superoxide dismutase.
Aerobic organisms depend on superoxide dismutase to suppress the formation of dangerous species of activated oxygen. Intraerythrocytic stages of the malaria parasite exist within a highly aerobic environment and cause the generation of increased amounts of activated oxygen. Plasmodium berghei in mice was found to derive a substantial amount of superoxide dismutase activity from the host cell cytoplasm. Plasmodia isolated from mouse red cells contained mouse superoxide dismutase, whereas rat-derived parasites contained the rat enzyme. This is believed to be the first example of the acquisition of a host cell enzyme by an intracellular parasite.
D000818:Animals; D004912:Erythrocytes / Q000201:enzymology / Q000469:parasitology; D007526:Isoelectric Point; D008288:Malaria / Q000201:enzymology*; D051379:Mice; D010962:Plasmodium berghei / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000502:physiology*
D013482:Superoxide Dismutase