title: Ultrastructural studies on the thymus gland after the administration of phenylhydrazine to bank voles (Clethrionomys glareolus).
abstract: The thymus glands of wild and laboratory reared bank voles (Clethrionomys glareolus) were examined for ultrastructural changes before and after the administration of low (20 mg/kg) and high (60 mg/kg) doses of phenylhydrazine (PhZ) given intraperitoneally on days 0, 1 and 3 of a dosing regime. Erythrocytes developed in focal aggregations in the subcapsular and outer cortical zones. There was a marked depletion of the subcapsular cortex following drug treatment that was reversed with time. A large number of granulocytes were visible in the cortex after PhZ, and mast cells developed in situ.
mesh_terms: D000818:Animals; D003411:Arvicolinae / Q000033:anatomy & histology*; D004912:Erythrocytes / Q000648:ultrastructure; D008407:Mast Cells / Q000648:ultrastructure; D008854:Microscopy, Electron; D010659:Phenylhydrazines / Q000494:pharmacology*; D013950:Thymus Gland / Q000648:ultrastructure*
chemical_list: D010659:Phenylhydrazines; C030299:phenylhydrazine