Immunity induced by inactivated poliovirus vaccine and excretion of virus.
Epidemiologic studies suggest that high levels of immunity induced by inactivated poliovirus vaccine could limit the spread of poliomyelitis in the community. Antibody induced by this vaccine had a marked effect on reducing pharyngeal virus excretion in children with poliovirus infection. Some reduction of fecal virus excretion was also observed, but high levels of serum antibody were required for this reduction.
D000914:Antibodies, Viral / Q000032:analysis; D002675:Child, Preschool; D005243:Feces / Q000382:microbiology; D006801:Humans; D007109:Immunity; D007223:Infant; D010614:Pharynx / Q000382:microbiology; D011051:Poliomyelitis / Q000276:immunology* / Q000635:transmission; D017955:Poliovirus / Q000302:isolation & purification; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology
D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated; D014613:Vaccines, Attenuated