On the construction of functional maps in positron emission tomography.
A linear algorithm for the rapid calculation of local rate constants is proposed. The method is applicable to the three-compartment models currently used in the analysis of positron camera measurements with [11C]methionine, [11C]deoxyglucose, and [11C]glucose. The same technique can also be used for the regional measurement of local blood flow with the aid of a freely diffusible tracer. The algorithm was applied to measurements on humans with [11C]glucose. As a comparison, the same data were also analyzed with a standard nonlinear technique. Good agreement between the two methods was obtained.
D001921:Brain / Q000378:metabolism / Q000502:physiology; D002250:Carbon Radioisotopes; D003847:Deoxyglucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008715:Methionine / Q000378:metabolism; D014055:Tomography, Emission-Computed / Q000379:methods*
D002250:Carbon Radioisotopes; D003847:Deoxyglucose; D008715:Methionine; D005947:Glucose