Infantile renal tumors associated with hypercalcemia. Characterization of intermediate-filament clusters.
Three cases of hypercalcemic infantile renal tumors were studied to identify the proteins related to their cytoplasmic 8- to 10-nm filament clusters. Immunofluorescence microscopy, using antibodies against vimentin, cytokeratin, and actin, led to the characterization of vimentin-positive filament clusters. We discuss the possibility of a mesenchymal origin for these tumors.
D003599:Cytoskeleton / Q000648:ultrastructure*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron