[Effect of the time before fixation on the yield of chromosome aberrations in a culture of human lymphocytes exposed to gamma rays at different stages of the mitotic cycle].
A comparative study was made of the yield of chromosome aberrations in human lymphocyte culture exposed to 60Co-gamma-rays (2 Gy) at different mitotic cycle stages the cells being fixed after 52 and 60 hr. It was shown that with the latter fixation time (60 hr) the frequency of chromosome aberrations after irradiation in G1 stage was substantially lower than that with the former one (52 hr) and, vice versa, it was higher after irradiation in S and G2 stages. The authors discuss the probable causes of the distinctions observed.
D002869:Chromosome Aberrations; D003037:Cobalt Radioisotopes; D003584:Cytological Techniques; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008938:Mitosis; D013997:Time Factors
D003037:Cobalt Radioisotopes
Vliianie srokov fiksatsii na vykhod aberratsiĭ khromosom v kul'ture limfotsitov cheloveka pri gamma-obluchenii v razlichnykh stadiiakh mitoticheskogo tsikla.