Beating heart muscle in a skeletal muscle bed.
Minced cardiac muscle from newborn rats was transplanted into a skeletal muscle bed of nude mice. The implanted tissue regenerated into autonomously beating heart muscle, the donor origin of which was shown by immunohistochemistry and isozyme analysis. Host skeletal muscle regeneration was stimulated compared with controls without implanted tissue.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D016027:Heart Transplantation; D006352:Heart Ventricles; D009132:Muscles / Q000502:physiology*; D011674:Pulse; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration