Effect of abdominal operations on survival after septic challenge in normal rats.
We evaluated the effect of 60% small-bowel enterectomy that removed 75% of Peyer's patches, and the effects of lesser abdominal operations, on the survival of rats following inducement of peritonitis. We divided 286 female Fischer rats weighing 140 to 200 g into four experimental and two control groups. Following enterectomy, rats recovered for ten to 14 days before peritonitis was induced by intraperitoneal injection of 0.7 mL/100 g of body weight of a solution of 4% hemoglobin and Escherichia coli (10(9)/mL). At 48 hours after enterectomy, the survival rate was better than that in rats not operated on or anesthetized. Survival rates for rats having lesser intra-abdominal operations were significantly greater after peritonitis than the rates for controls, but were similar to rates for rats having enterectomies. Our results suggest that intra-abdominal operation of minimal or large magnitude is associated with improved survival from hemoglobin-E coli adjuvant peritonitis.
D000758:Anesthesia / Q000401:mortality; D000818:Animals; D004927:Escherichia coli Infections / Q000401:mortality*; D005260:Female; D007421:Intestine, Small / Q000276:immunology / Q000601:surgery*; D007813:Laparotomy / Q000401:mortality; D010538:Peritonitis / Q000276:immunology / Q000401:mortality*; D010581:Peyer's Patches / Q000276:immunology; D011183:Postoperative Complications / Q000401:mortality; D051381:Rats; D011916:Rats, Inbred F344