The effect of subtotal resection on the dose of radiation required to cure the rat rhabdomyosarcoma BA1112.
Dose response curves were established for local control of the rat rhabdomyosarcoma BA1112 for radiation alone and for radiation following a cytoreductive operation. Removal of one-half of the tumor prior to irradiation did not significantly alter the dose of radiation necessary to cure 50 per cent of the tumors. This experimental result confirms the theoretic predictions and suggests that, to be useful in combination with radiation, surgical treatment must remove in excess of 90 per cent of the tumor.
D000818:Animals; D002986:Clinical Trials as Topic; D004307:Dose-Response Relationship, Radiation; D009374:Neoplasms, Experimental / Q000532:radiotherapy / Q000601:surgery; D011879:Radiotherapy Dosage; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D012208:Rhabdomyosarcoma / Q000532:radiotherapy / Q000601:surgery*