Regulation of the coagulant activity and surface binding of high molecular weight kininogen.
Cleavage of the procofactor, high molecular weight kininogen, by kallikrein, is required for expression of it cofactor activity. Coagulant activity associated with the light chain of high molecular weight kininogen is destroyed by proteolysis by factor XIa. The heavy chain of high molecular weight kininogen augments the binding of the light chain to activating surfaces without itself expressing coagulant activity.
D001779:Blood Coagulation Factors / Q000378:metabolism*; D005172:Factor XI / Q000378:metabolism; D005174:Factor XII / Q000378:metabolism; D015956:Factor XIIa; D015945:Factor XIa; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism; D007704:Kininogens / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism; D011485:Protein Binding
D001779:Blood Coagulation Factors; D007704:Kininogens; D010446:Peptide Fragments; D005174:Factor XII; D005172:Factor XI; D007610:Kallikreins; D015945:Factor XIa; D015956:Factor XIIa