Effects of interleukin-1 (IL-1) and interleukin-2 (IL-2) on the in vivo growth and differentiation of progenitors of natural killer (NK) cells.
We evaluated the possible modulating activity of interleukin-1 (IL-1) and interleukin-2 (IL-2) on in vivo growth of mouse progenitors of Natural Killer (NK) cells. Our data show that both IL-1 and IL-2 are able to stimulate the maturation of NK reactivity of infant mice as well as the regeneration of NK reactivity of lethally irradiated and reconstituted bone marrow chimeras.
D000818:Animals; D002454:Cell Differentiation; D005260:Female; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D007375:Interleukin-1 / Q000502:physiology*; D007376:Interleukin-2 / Q000502:physiology*; D007694:Killer Cells, Natural / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D007375:Interleukin-1; D007376:Interleukin-2