Murine neonate hemopoiesis following in utero total-body irradiation.
Irradiation (50-200 rad of cobalt-60 gamma rays) on day 10.5 of gestation in the mouse had the following residual effects on neonate and juvenile hemopoiesis: (a) greater damage observed in the day-15 juvenile than in the day-9 neonate; (b) greater fluctuation of peripheral blood hemogram indices from normal values in the day-15 animal than in the day-9 animal; (c) spleen cellularity affected more than bone marrow cellularity; (d) greater radiation injury reflected by bone marrow hemopoietic progenitor cells (erythroid: BFU-E and CFU-E; granulocyte-macrophage: GM-CFC; megakaryocyte: Meg-CFC), and (e) a more pronounced decrease in medulla- and spleen-erythropoietic activity with each increase in dose of irradiation.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D006410:Hematopoiesis / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011247:Pregnancy; D013154:Spleen / Q000528:radiation effects; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes