title: Influence of the genotype of mice on the effect of interferon on phagocytic activity of macrophages.
abstract: The influence of genotype on interferon effect on phagocytic activity of unstimulated mouse peritoneal macrophages (MPM) was studied in in vitro experiments. Treatment of MPM from BALB/c and ICR mice with mouse fibroblast interferon (MuIFN-beta) enhanced the ingestion of non-opsonized Escherichia coli. This effect was dose-dependent and neutralized by anti-interferon globulin. MPM from C57B1/6 mice were not stimulated by the same treatment. Treatment of MPM with pH 2-sensitive immune interferon (MuIFN-gamma) depressed the ingestion independently on the genotype of mice.
mesh_terms: D000818:Animals; D004926:Escherichia coli / Q000378:metabolism; D005260:Female; D005838:Genotype; D007370:Interferon Type I / Q000235:genetics / Q000502:physiology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D010587:Phagocytosis; D013045:Species Specificity
chemical_list: D007370:Interferon Type I