Potentiation of the actions of insulin by taurine.
Taurine was found to mediate several changes in myocardial metabolism. In the absence of insulin, only oxygen consumption was significantly elevated by taurine; however, in the presence of 2.5 U/L insulin the amino acid caused the stimulation of glycolysis and glycogenesis, as well as oxygen utilization. These effects of taurine were shown to be dependent on insulin concentration, suggesting a link between the two substances. Measurements of key metabolic intermediates revealed that taurine stimulated glycolysis by enhancing flux through phosphofructokinase. Similarly, it was shown that glycogenesis was promoted because of the increase in glycogen synthase I and decrease in phosphorylase alpha activity. Several possible mechanisms for the observed changes are discussed.
D000818:Animals; D004357:Drug Synergism; D006019:Glycolysis / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000494:pharmacology*
D007328:Insulin; D013654:Taurine