title: The direct perfusion of surgical wounds with local anaesthetic solution: an approach to postoperative pain?
abstract: A simple technique of wound perfusion with bupivacaine (Marcain) which provides sustained postoperative analgesia is described. No complications nor side effects related to toxicity, hypersensitivity, infection, or impaired wound healing were encountered. Postoperative pain was reduced and analgesic requirements were significantly lower in patients undergoing both intermittent (P less than 0.01) and continuous (P = 0.1) wound perfusion (Student t test). Perfusion with isotonic saline was also found to be effective. This may represent a true therapeutic effect attributable to the removal or dilution of pain mediating substances in the wound.
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000627:therapeutic use; D002045:Bupivacaine / Q000008:administration & dosage / Q000627:therapeutic use; D002763:Cholecystectomy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009892:Opium / Q000627:therapeutic use; D010149:Postoperative Pain / Q000628:therapy*; D010477:Perfusion / Q000379:methods; D010865:Pilot Projects; D011897:Random Allocation
chemical_list: D000779:Anesthetics, Local; D009892:Opium; D002045:Bupivacaine