Bronchodilator effect of two inhaled H1-receptor antagonists, clemastine and chlorpheniramine, in wheezy school-children.
Chlorpheniramine, clemastine and a placebo have been compared for their ability to relieve bronchoconstriction in 14 childhood asthmatics between the ages of 6 and 14 years. Each attended on three separate occasions, inhaling a 2 ml solution containing either 4 mg of chlorpheniramine, 1 mg of clemastine or placebo under double-blind conditions. Lung function was assessed before and at intervals for 30 minutes after the inhalation by peak expiratory flow and spirometry. Each child then inhaled 5 mg of salbutamol in 2 ml of water and the lung function tests were repeated. A significant degree of bronchodilatation was seen 30 minutes after all three inhalations, but considerable coughing occurred after inhaling chlorpheniramine. Actual changes in raw data showed a significant improvement after clemastine between the 20 and 30 minute recordings and that at 30 minutes clemastine produced significantly greater bronchodilatation than placebo. Inhaled H1-receptor antagonists merit further investigation to delineate their role in childhood asthma.
D000420:Albuterol / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002744:Chlorpheniramine / Q000627:therapeutic use*; D002974:Clemastine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D011759:Pyrrolidines / Q000627:therapeutic use*
D011759:Pyrrolidines; D002744:Chlorpheniramine; D002974:Clemastine; D000420:Albuterol