A monoclonal antibody useful for the differential diagnosis between malignant lymphoma and nonhematopoietic neoplasms.
A monoclonal antibody designated as T29/33, which recognizes a major cell surface glycoprotein of hematopoietic cells, was tested as a possible tool to distinguish lymphoma from nonhematopoietic tumors having a similar morphologic appearance by light microscopy. Each of the 40 lymphomas studied by immunofluorescence and/or immunoperoxidase on frozen sections revealed the presence of the corresponding antigen, whereas 110 control tumors of various nonhematopoietic origins were negative. It was concluded that the T29/33 antibody may be of value in resolving the diagnostic problems presented by tumors in which the differential diagnosis is between non-Hodgkin's lymphoma and nonlymphoid tumors.
D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008223:Lymphoma / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000175:diagnosis; D011947:Receptors, Antigen, B-Cell / Q000276:immunology
D000911:Antibodies, Monoclonal; D006023:Glycoproteins; D011947:Receptors, Antigen, B-Cell