title: Growth inhibitory effect of antibiotic tetaine on yeast and mycelial forms of Candida albicans.
abstract: The mycelial (M) form of Candida albicans is more sensitive to the action of the antibiotic tetaine than the yeast (Y) form. Tetaine, at low concentrations about 1 microgram/ml also inhibits Y-M transition. It causes severe deformation of cells, agglutination and inhibits septum formation in the yeast forms. Tetaine action is reversed by dipeptides in both forms and by tripeptides in M form. N-acetyl glucosamine is a powerful antagonist of tetaine action on both morphological forms. Tetaine action on mycelial forms is slightly antagonised by N-acetyl mannosamine and very powerfully by glutamine.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000606:Amino Sugars / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D004151:Dipeptides / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D000606:Amino Sugars; D000900:Anti-Bacterial Agents; D004151:Dipeptides; D010455:Peptides; C006674:bacilysin