Anti-IgM antibodies may regulate the humoral response to paternal HLA antigens in pregnant women.
Anti-IgM antibodies were detected in sera of pregnant women but not in non-pregnant women and men. Anti-IgM activity was associated negatively with presence of anti-HLA antibodies. This finding suggests possible immunoregulatory influence of anti-IgM on humoral response against major histocompatibility antigens in pregnancy. The possibility of a similar mechanism being responsible for enhancement of kidney graft survival due to blood transfusions is discussed.
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000917:Antibody Formation; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D011247:Pregnancy
D000888:Antibodies, Anti-Idiotypic; D006680:HLA Antigens; D007075:Immunoglobulin M