Distribution of secretory component in non-cancerous human gastric mucosa.
Immunological detection of secretory component (SC) in non-cancerous human gastric mucosa was carried out by the peroxidase-anti-peroxidase (PAP) method using several fixatives. SC was detected in the generative zone or mucous neck of normal gastric mucosa without intestinal metaplasia (IM) and in absorptive cells of IM of the stomach. The deep part of complete type IM showed a larger amount of SC than the superficial part. These findings suggested that the appearance of SC in gastric mucosa would be relevant to the immunity of glandular epithelium. In addition, SC was also detected in pyloric gland cells in specimens fixed with cold 95% ethanol. From these results, SC was considered to be a normal constituent and one of the developmental proteins in the gastric mucosa.
D005753:Gastric Mucosa / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007128:Immunoglobulin Fragments / Q000032:analysis*; D007422:Intestines / Q000473:pathology; D008679:Metaplasia / Q000276:immunology; D012635:Secretory Component / Q000032:analysis*; D014018:Tissue Distribution
D007128:Immunoglobulin Fragments; D012635:Secretory Component