[Total IgE synthesis in diabetic children].
Antibodies (ICA and other organ-specific and non-organ-specific antibodies), HLA histocompatibility antigens and serum IgE levels were analysed in 27 diabetic children aged 2 to 14 years. The results obtained are as follows : 59% of examined subjects had ICA; the HLA-B8 incidence in our diabetic patients was significantly higher (p less than 0.0005) than in normal population; serum IgE levels were higher than +1 SD in 67% of patients; this percentage reaches 76% in diabetics with ICA and 86% in diabetics with ICA and HLA-B8. Enhancement of IgE production could be the consequence of a reduction in the number and/or function of suppressor T lymphocytes.
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis; D015795:HLA-B8 Antigen; D006649:Histocompatibility Antigens / Q000032:analysis; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007515:Islets of Langerhans / Q000276:immunology
D001323:Autoantibodies; D006680:HLA Antigens; D015795:HLA-B8 Antigen; D006649:Histocompatibility Antigens; D007073:Immunoglobulin E
Synthèse des IgE totales chez les enfants diabétiques.