title: Extradural versus intramuscular diamorphine. A controlled study of analgesic and adverse effects in the postoperative period.
abstract: The effects of diamorphine hydrochloride 0.1 mg/kg, given either extradurally or intramuscularly for postoperative analgesia were compared in two randomised double-blind studies involving 39 patients undergoing thoracotomy and major gynaecological surgery. Assessments were made at fixed intervals after the administration of diamorphine and consisted of the measurement of pain or analgesic effect. Segmental, sympathetic and any adverse effects were sought. There was no significant difference in the quality of analgesia between the two groups in either trial. Extradural diamorphine provided safe and effective analgesia of rapid onset, with no specific undesirable side-effects. In both studies, analgesia was more prolonged following extradural administration. The relative proportion of spinal binding may be increased after extradural administration and this may be reflected in the prolonged analgesia observed.
mesh_terms: D000328:Adult; D000368:Aged; D000698:Analgesia; D000767:Anesthesia, Epidural; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005836:Genitalia, Female / Q000601:surgery; D003932:Heroin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control*; D011897:Random Allocation; D013903:Thoracic Surgery; D013997:Time Factors
chemical_list: D003932:Heroin