Failure of meningococcal vaccination to stop the transmission of meningococci in Nigerian schoolboys.
A combined group A and group C meningococcal polysaccharide vaccine was given to 438 Nigerian schoolboys shortly before an outbreak of group A meningococcal disease occurred in their school. Four months after vaccination the carriage rate of group A meningococci among vaccinated subjects (11%) was no different from that found among the controls (12%), although a good antibody response to both components of the vaccine was observed. One case of group A meningococcal disease was recorded amongst 438 vaccinated subjects while five cases occurred among 874 controls.
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D002353:Carrier State / Q000517:prevention & control*; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D009549:Nigeria; D011897:Random Allocation; D013997:Time Factors; D014611:Vaccination
D000907:Antibodies, Bacterial