Glutathione peroxidase blockage inhibits prostaglandin biosynthesis in rat platelets and aorta.
In the present study we demonstrated that the compound 3-amino-1,2,4-triazole (AMT) is a strong inhibitor of erythrocyte glutathione peroxidase (GSH-Px) activity. Moreover, AMT inhibits arachidonic-induced malondialdehyde formation in platelet-rich plasma and prostacyclin-like activity generation in aorta rings. These results give new lines of evidence on the connection between GSH-Px activity and prostaglandin synthesis in rat platelets and arterial vessel wall.
D000640:Amitrole / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors*; D008297:Male; D008314:Malonates / Q000096:biosynthesis*; D008315:Malondialdehyde / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014230:Triazoles / Q000494:pharmacology*
D008314:Malonates; D014230:Triazoles; D008315:Malondialdehyde; D011464:Epoprostenol; D005979:Glutathione Peroxidase; D000640:Amitrole