Effects of epidermal growth factor on deoxyribonucleic acid synthesis and stomach weight in hypophysectomized adult mice.
Epidermal growth factor (EGF) or saline was administered intraperitoneally to hypophysectomized adult male CD2F1 mice or intact controls at 0700 hr. Subgroups of mice were killed at 4, 8, or 12 hr after injection. EGF was shown to stimulate [3H]TdR incorporation into DNA into several organs as previously reported. The response to EGF was found to be enhanced in both hypophysectomized and fasted mice. Differences in [3H]TdR incorporation into DNA, corneal epithelium mitotic index, RNA in pancreas and kidney of hypophysectomized and intact mice are reported. EGF was shown to result in stomach enlargement due to increased luminal contents in both hypophysectomized and intact mice.
D000818:Animals; D004261:DNA Replication / Q000187:drug effects*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004947:Esophagus / Q000187:drug effects / Q000378:metabolism; D005215:Fasting; D005753:Gastric Mucosa / Q000378:metabolism; D007016:Hypophysectomy; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013270:Stomach / Q000187:drug effects*; D013997:Time Factors
D004815:Epidermal Growth Factor