title: [Effect of a live enteral dysentery vaccine from spontaneous Flexner mutant 2a 516m on the immunoglobulin-producing cell count in the large intestine mucosa in dysentery].
abstract: The influence of vaccinal therapy with live oral dysentery vaccine prepared from S. flexneri 2a 516M on the content of immunoglobulin-producing cells in the mucous membrane of the large intestine was studied. A considerable increase in the number of IgA- and IgM-synthetizing cells was shown to occur in the course of the infectious process in acute dysentery. In chronic dysentery the content of IgA- and IgM-synthetizing cells in patients was considerably lower than in a smooth course of acute dysentery. The use of the vaccine for the therapy of patients with chronic and especially acute dysentery resulted in a considerable rise in the number of plasma cells synthetizing IgA, IgM and IgG.
mesh_terms: D000293:Adolescent; D000328:Adult; D000921:Antibody-Producing Cells / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology / Q000627:therapeutic use*; D002452:Cell Count; D004341:Drug Evaluation; D004405:Dysentery, Bacillary / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000276:immunology*; D007420:Intestine, Large / Q000276:immunology*; D008875:Middle Aged; D009154:Mutation; D012763:Shigella flexneri / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D007136:Immunoglobulins
vernacular_title: Vliianie zhivoĭ dizenteriĭnoĭ enteral'noĭ vaktsiny iz spontannogo mutanta Fleksnera 2a 516m na soderzhanie immunoglobulinprodutsiruiushchikh kletok v slizistoĭ tolstoĭ kishke bol'nykh dizenterieĭ.