Deficiency of IgG subclasses in mothers of infants with group B streptococcal septicemia.
Serum IgG subclasses were studied in 19 mothers of infants with serious infections caused by group B streptococci (GBS) and compared with a control group of 20 mothers of healthy infants. 13 of 19 mothers showed decreased subclass levels: 10 of 19 low IgG2, 9 of 19 low IgG1 and 4 of 19 low IgG3. The levels of IgG1, IgG2 and IgG3 were significantly lower among mothers of GBS-infected infants than among the controls. Thus, there is indirect evidence that the infants were immunodeficient at birth.
D000328:Adult; D004406:Dysgammaglobulinemia / Q000151:congenital* / Q000276:immunology; D005260:Female; D006801:Humans; D017099:IgG Deficiency; D007074:Immunoglobulin G / Q000145:classification; D007231:Infant, Newborn; D013290:Streptococcal Infections / Q000235:genetics*; D013292:Streptococcus agalactiae
D007074:Immunoglobulin G