Dissolution studies of microencapsulated indomethacin; effect of method and medium on dissolution.
In vitro dissolution studies of microencapsulated indomethacin showed that the USP paddle method was superior to the USP basket method in that the drug release was higher and more uniform with the paddle. Simulated intestinal fluid (pH 7.2) was an appropriate medium to use for dissolution studies on prolonged-release microcapsules.
D001826:Body Fluids; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002621:Chemistry; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods; D007213:Indomethacin / Q000493:pharmacokinetics*; D008954:Models, Biological
D002214:Capsules; D003692:Delayed-Action Preparations; C013517:ethyl cellulose; D002482:Cellulose; D007213:Indomethacin