Association of Gm allotypes with the occurrence of ankylosing spondylitis in HLA-B27-positive anterior uveitis.
We studied immunoglobulin Gm and Km allotypes in 54 patients with HLA-B27-positive anterior uveitis and in 204 healthy controls. No differences were noted between the two groups. Dividing the patients with anterior uveitis into those with ankylosing spondylitis (No. = 22) and those without it (No. = 32), produced interesting results. The Gm 1, 3, 17; 23; 5, 13, 21 phenotype was significantly (P = .007) increased in those within the ankylosing spondylitis and anterior uveitis group. Of these 22 patients, ten (45.5%) carried the Gm 1, 3, 17; 23; 5, 13, 21 phenotype compared to two of 32 (6.3%) in those with anterior uveitis alone and 33 of 204 (16.2%) normal controls. There were no significant differences between patients and controls in the frequencies of the other phenotypes tested.
D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007074:Immunoglobulin G / Q000235:genetics*; D008297:Male; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000235:genetics*; D014605:Uveitis / Q000150:complications / Q000235:genetics*
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G