Feto-maternal relationships between vitamin D metabolites in Israeli Bedouins and Jews.
The major metabolites of vitamin D, 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, and 1,25-dihydroxyvitamin D were assayed in the blood of mothers at delivery and in the cord blood of their infants. Twelve Bedouin women and nine Jewish women were investigated; all lived in the Negev desert in Israel. All three vitamin D metabolites were significantly lower in cord than in maternal blood in both groups. Bedouin mothers and infants had significantly lower levels of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D than did Jewish mothers and infants. Concentrations of 1,25-dihydroxyvitamin D did not differ significantly between the ethnic groups and in both maternal groups were well above the normal range (Bedouins 83.6 pg/ml +/- 11.3; Jews 98.6 pg/ml +/- 12.3). Cord and maternal values for this metabolite were significantly correlated (r = 0.71, p less than 0.001).
D015650:24,25-Dihydroxyvitamin D 3; D000328:Adult; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000097:blood; D005006:Ethnicity; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007557:Israel; D007585:Jews; D011247:Pregnancy; D014807:Vitamin D / Q000097:blood / Q000378:metabolism*
D004100:Dihydroxycholecalciferols; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002112:Calcifediol