[Experimental minute gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine in dogs].
150 micrograms/day of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) was administered to a total of 8 dogs, (4 mongrels at age of 4 months and 4 beagles at age of 6 months) over a period of 8 months by Kurihara 's method. As a result of the administration, we found development of minute cancer as follows: In 3 animals, male beagle killed at 575th day, male mongrel at 1, 105th days and male mongrel at 1, 245th days, a total of 20 neoplasms of the stomach was found (18 early cancers and 2 advanced cancers). 13 of which being the minute cancer measuring less than 0.5 cm. There were 11 mucosal cancers and 2 submucosal cancers. When classified by the macroscopic pathological type, none was classified as the elevated type (I, IIa types), 5 lesions as the flat type (IIb type), and 8 lesions as the depression type (IIc type). Two lesions of submucosal cancer belonged to IIc type. When classified by the histological type, 2 were classified as papillary adenocarcinoma, 2 as well differentiated tubular adenocarcinoma, 1 as moderately differentiated tubular adenocarcinoma, 5 as poorly differentiated adenocarcinoma and 3 as signet-ring cell carcinoma.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced* / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D004285:Dogs; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives*; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D008769:Methylnitronitrosoguanidine; C013525:ENNG