Target antigens of transmission-blocking immunity on gametes of plasmodium falciparum.
Three proteins of apparent molecular weights on reducing SDS-PAGE of 255, 59, and 53 kilodaltons have been identified as the targets on gametes of P. falciparum malaria of two monoclonal antibodies (MAbs) that act synergistically to block transmission of the parasites to mosquitoes.
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000502:physiology*; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000032:analysis* / Q000276:immunology / Q000302:isolation & purification; D001667:Binding, Competitive; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology; D008288:Malaria / Q000276:immunology* / Q000469:parasitology / Q000635:transmission; D008297:Male; D008970:Molecular Weight; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity
D000911:Antibodies, Monoclonal; D000941:Antigens