Interaction of dietary vitamin C and vitamin E on guinea pig immune responses to mitogens.
Guinea pigs were fed semipurified diets with 0.2 g/kg vitamin C and either 0, 30 or 200 mg/kg all-rac-alpha-tocopheryl acetate or 10 mg/kg vitamin C and either 0, 30 or 200 mg/kg all-rac-alpha-tocopheryl acetate for 4 weeks. Animals were killed, and blastogenic responses of splenocytes to T- and B-cell mitogens were measured. Both T- and B-cell responses were significantly depressed in vitamin E-deficient guinea pigs when compared to responses from guinea pigs fed diets containing vitamin E. The two dietary levels of vitamin C examined did not affect the magnitude of these responses. The higher dietary vitamin C, however, increased the vitamin E content of the lung at all levels of vitamin E intake.
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D004032:Diet; D006168:Guinea Pigs; D008070:Lipopolysaccharides / Q000494:pharmacology; D008168:Lung / Q000378:metabolism; D008297:Male; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D014810:Vitamin E / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*
D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins; C028784:phytohemagglutinin-P; D003208:Concanavalin A; D014810:Vitamin E; D001205:Ascorbic Acid