Penetration of ceftazidime into serum, myometrium, endometrium, salpinges and subcutaneous tissue.
Thirty-one patients received an intravenous bolus injection of 2 g ceftazidime over 5 min at various times before abdominal or vaginal hysterectomy. Ceftazidime concentrations in myometrium, endometrium and salpinges reached 34% to 43% of the corresponding serum levels. Subcutaneous tissue concentrations were significantly lower. Tissue concentrations of 8 mg/l were maintained for at least 5 h.
D002442:Ceftazidime; D002511:Cephalosporins / Q000378:metabolism* / Q000627:therapeutic use; D004717:Endometrium / Q000378:metabolism*; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009215:Myometrium / Q000378:metabolism*; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control; D014018:Tissue Distribution
D002511:Cephalosporins; D002442:Ceftazidime