An association between cutaneous sensitivity to histamine and HLA phenotype.
Four hundred and twenty randomly chosen subjects from a normal population were HLA typed and tested for cutaneous sensitivity to histamine by prick testing with 5 concentrations of histamine (10(-3), 10(-2), 10(-1), 1, 10 mg X ml-1). Positive responses to 10(-1) mg X ml-1 histamine occurred in 41% of the subjects, and particularly those with HLA-B7 (55%) (p less than 0.005). It is concluded that genes within the major histocompatibility complex influence cutaneous responses to histamine.
D006680:HLA Antigens; D015235:HLA-B Antigens; D015793:HLA-B7 Antigen; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D010641:Phenotype; D012867:Skin / Q000187:drug effects* / Q000276:immunology; D012882:Skin Tests
D006680:HLA Antigens; D015235:HLA-B Antigens; C035015:HLA-B12 antigen; D015793:HLA-B7 Antigen; D006632:Histamine