title: Increased oestrogen production and adrenal cortical hyperfunction in patients with pulmonary disease and clubbing of the fingers.
abstract: Raised serum oestradiol levels were demonstrated in men and postmenopausal women with pulmonary disease and clubbing of the fingers. The site of production is thought to be a hyperfunctioning adrenal cortex; this conclusion is supported by the finding of elevated adrenocortical responses to intramuscular injection of adrenocorticotrophic hormone.
mesh_terms: D000304:Adrenal Cortex Function Tests; D000308:Adrenocortical Hyperfunction / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D000368:Aged; D002283:Carcinoma, Bronchogenic / Q000097:blood / Q000150:complications; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood; D008297:Male; D008593:Menopause; D008875:Middle Aged; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000097:blood* / Q000150:complications; D011656:Pulmonary Emphysema / Q000097:blood
chemical_list: D004958:Estradiol; D000324:Adrenocorticotropic Hormone