[Comparative effects of an alpha 1 and beta 1-2 blocker (labetalol) and a beta-1 blocker (atenolol) in the hypertensive patient].
The effects of a single oral dose and of an 8 week treatment with labetalol--an alpha 1- and beta 1-2-adrenoceptor blocking agent--and with atenolol--a beta 1-adrenoceptor blocking agent--were compared in 52 hypertensives. A single oral dose of atenolol induced a marked bradycardia without decrease in blood pressure. On the contrary labetalol lowered blood pressure but not resting heart rate. After an 8 week treatment both drugs exhibited a similar antihypertensive effect. However labetalol did not decrease heart rate and plasma renin activity as markedly as atenolol did. It was concluded that the alpha 1 blocking properties of labetalol were of importance in the development of the antihypertensive properties that this drug exhibits after a single or multiple administrations.
D000328:Adult; D001262:Atenolol / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007741:Labetalol / Q000627:therapeutic use*; D008297:Male; D012083:Renin / Q000097:blood; D013997:Time Factors
D004983:Ethanolamines; D001262:Atenolol; D012083:Renin; D007741:Labetalol
Effets comparés d'un alpha 1- et beta 1-2-bloquant (labétalol) et d'un beta 1-bloquant (aténolol) chez l'hypertendu.