title: Sample sizes for the exact test of 'no interaction' in 2 X 2 X 2 tables.
abstract: The exact two-sided test of the hypothesis of 'no interaction' in a 2 X 2 X 2 table with fixed totals of rows X columns is considered. A method of approximating the power of the test, based on the limiting conditional distribution of a cell entry (Godambe and Harkness, 1975, Communications in Statistics 4, 699-709), is introduced and found to provide a close fit. This method can be utilized to calculate the sample sizes required to detect interaction effects with a pregiven power.
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology; D002986:Clinical Trials as Topic; D004812:Epidemiologic Methods; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D012306:Risk
chemical_list: D004967:Estrogens