Serum transcobalamin levels as an early indicator of bone marrow engraftment following transplantation.
Three B12 binding proteins, the transcobalamins TCI, TCII and TCIII, were determined serially in the serum of five patients who underwent bone marrow transplantation. The increase in TCII, followed by the increase in TCI, proved to be an early indicator of bone marrow regeneration, reaching a peak of up to twice its normal levels at least 5 d prior to the rise of the peripheral white blood cell count.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D001853:Bone Marrow / Q000378:metabolism / Q000502:physiology; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008297:Male; D012038:Regeneration; D013997:Time Factors; D014155:Transcobalamins / Q000378:metabolism*
D014155:Transcobalamins