title: The isolation and characterization of a mutant strain of Saccharomyces cerevisiae that requires a long chain base for growth and for synthesis of phosphosphingolipids.
abstract: A mutant of Saccharomyces cerevisiae has been obtained that shows an absolute growth requirement for long chain bases found in sphingolipids. In the absence of a long chain base, the cells are unable to synthesize the phosphoinositol-containing sphingolipids characteristic of yeast. These results suggest that one or more of the yeast sphingolipids plays a vital biological role.
mesh_terms: D002853:Chromatography, Liquid; D009154:Mutation; D010743:Phospholipids / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000302:isolation & purification; D013107:Sphingolipids / Q000096:biosynthesis*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D010743:Phospholipids; D013107:Sphingolipids; D013110:Sphingosine; C005682:safingol