title: Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells.
abstract: Rat cells transformed by the highly oncogenic adenovirus 12 lack at least two cellular proteins which are present in cells transformed by the non-oncogenic adenovirus 5 and in untransformed cells. One protein has been identified as the heavy chain of the rat class I major histocompatibility complex. This finding may explain the difference in oncogenicity between adenoviral species.
mesh_terms: D000256:Adenoviridae; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002472:Cell Transformation, Viral; D004591:Electrophoresis, Polyacrylamide Gel; D006649:Histocompatibility Antigens / Q000032:analysis*; D008285:Major Histocompatibility Complex; D008565:Membrane Proteins / Q000032:analysis; D051379:Mice; D008970:Molecular Weight; D009858:Oncogenic Viruses; D014176:Protein Biosynthesis; D051381:Rats; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D006649:Histocompatibility Antigens; D008565:Membrane Proteins; D001613:beta 2-Microglobulin