title: Some characteristics of steroid diabetes: a study in renal-transplant recipients receiving high-dose corticosteroid therapy.
abstract: Risk factors and course of steroid diabetes were investigated in 145 renal-transplant recipients who were given a high-dose steroid regimen. Persistent steroid diabetes developed in 25% of the patients and transient diabetes in another 22%. When antidiabetic therapy was required, insulin had to be given in 50%. The incidence of steroid diabetes correlated with steroid dose, age, body weight, and diabetes heredity but not with abnormal glucose tolerance or with another complication of steroid therapy, posterior-pole lenticular cataract. There was no association with HLA-A and B antigens. Thus, steroid diabetes is a frequent complication of high-dose corticosteroid therapy and is similar to type II diabetes. However, it often requires insulin therapy.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000367:Age Factors; D001835:Body Weight; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000235:genetics; D005951:Glucose Tolerance Test; D006801:Humans; D016030:Kidney Transplantation; D012306:Risk
chemical_list: D000305:Adrenal Cortex Hormones