Liver dysfunction in haemophilia A, B and other hereditary haemorrhagic disorders.
Seventy patients with Haemophilia A, B, von Willebrand's disease and Factor V deficiency had their liver functions studied. Twenty-five patients (36%) were found to have significant "transaminitis" (elevated SGPT/SGOT). Nine patients (13%) had positive Hepatitis B surface antigen (HBsAg). The incidence of Hepatitis B surface antibody (anti-HBs) in the study group was 74%. All patients were asymptomatic at the time of study. This asymptomatic liver dysfunction will require close monitoring for clinical significance.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005166:Factor V Deficiency / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006467:Hemophilia A / Q000276:immunology / Q000503:physiopathology*; D002836:Hemophilia B / Q000276:immunology / Q000503:physiopathology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014842:von Willebrand Diseases / Q000276:immunology / Q000503:physiopathology*
D006514:Hepatitis B Surface Antigens; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase