Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus.
The effect of dimethyl sulphoxide and other cryoprotective compounds on the sensitivity of cells to polypeptide toxins and to poliovirus was tested. In the presence of these compounds, which all affect membrane fluidity, the cells were protected against the toxic proteins and against poliovirus. The large protection obtained was not due to reduced binding and endocytosis of the toxins. Apparently, the cryoprotective compounds interfere with the entry of toxins and of the poliovirus genome across the cell membrane.
D000036:Abrin / Q000494:pharmacology; D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004167:Diphtheria Toxin / Q000494:pharmacology; D004705:Endocytosis / Q000187:drug effects; D005559:Formamides / Q000494:pharmacology; D037102:Lectins / Q000494:pharmacology; D037121:Plant Lectins; D017955:Poliovirus / Q000502:physiology*; D054790:Ribosome Inactivating Proteins, Type 2; D012276:Ricin / Q000494:pharmacology; D014118:Toxins, Biological / Q000494:pharmacology*; D014508:Urea / Q000494:pharmacology
D000081:Acetamides; D004167:Diphtheria Toxin; D005559:Formamides; D037102:Lectins; D037121:Plant Lectins; D054790:Ribosome Inactivating Proteins, Type 2; D014118:Toxins, Biological; D000036:Abrin; C016004:modeccin; D014508:Urea; D012276:Ricin; D004121:Dimethyl Sulfoxide