The role of catecholamines in the control of gastric acid secretion during insulin hypoglycaemia and modified sham feeding.
The modified sham feeding procedure has been advocated to replace the insulin test as the method of choice for the assessment of denervation after vagotomy. One of the reasons for this changing attitude is the assumption that insulin hypoglycaemia causes non-cholinergic stimulation of acid secretion, possibly mediated via the sympatho-adrenal system. This study has therefore compared the effects of these two different tests on acidity and release of catecholamines into the circulation in 7 duodenal ulcer patients 6 weeks after highly selective vagotomy. It was found that insulin, but not modified sham feeding, caused a marked increase in plasma adrenaline and noradrenaline concentrations whereas gastric acid secretion was of a similar magnitude in the two tests. The results suggest that the increased plasma catecholamine levels during insulin hypoglycaemia do not influence gastric acid secretion in duodenal ulcer patients.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000097:blood* / Q000601:surgery; D004837:Epinephrine / Q000097:blood*; D005260:Female; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D014629:Vagotomy, Proximal Gastric
D001786:Blood Glucose; D007328:Insulin; D009638:Norepinephrine; D004837:Epinephrine