title: The induction of mutation and recombination following UV irradiation during meiosis in Saccharomyces cerevisiae.
abstract: Irradiation of yeast cultures with ultraviolet light at discrete stages during meiosis produces cyclic variations in sensitivity, i.e. cells are more sensitive to the lethal effects of UV light prior to entry into the meiotic DNA synthesis, and this corresponds to a peak of induction of point mutation. Cells become more resistant to both induced point mutation and lethality as they enter meiotic DNA synthesis, but become more sensitive again during spore formation. The induced level of intragenic recombination rises during the period of commitment to recombination to a level indistinguishable from the full meiotic level of spontaneous intragenic recombination. Induced reciprocal recombination remains above the spontaneous level up to the point of commitment to sporulation.
mesh_terms: D008540:Meiosis / Q000528:radiation effects*; D009154:Mutation / Q000528:radiation effects*; D011995:Recombination, Genetic / Q000528:radiation effects*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000528:radiation effects*; D013172:Spores, Fungal; D014466:Ultraviolet Rays