Replication of Paget cells in mammary and extramammary Paget's disease.
Replication of Paget cells in mammary and extramammary Paget's disease was evaluated by autoradiography after incorporation of tritiated thymidine. Neoplastic cells proliferated in the deepest layers of the epidermis suggesting a topographical control of their multiplication similar to that of the normal epidermis.
D000328:Adult; D000368:Aged; D001345:Autoradiography; D001943:Breast Neoplasms / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D002455:Cell Division; D004727:Endothelium / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D008940:Mitotic Index; D010145:Paget Disease, Extramammary / Q000473:pathology*; D010144:Paget's Disease, Mammary / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000473:pathology