A unique protein in normal human cerebrospinal fluid.
On analysis of cerebrospinal fluid (CSF) samples from normal volunteer donors by high-resolution zone electrophoresis on agarose gel, an electrophoretically homogeneous protein band consistently appeared in the gamma-globulin region. Application of immunofixation electrophoresis in attempts to identify the band with use of monospecific antibodies against individual human serum proteins and against heavy- and light-chain immunoglobulins as well as polyvalent antisera did not produce a positive immunoprecipitation reaction with the protein band. The serum samples from these subjects did not show similar bands. Therefore, we conclude that this protein band is a normally occurring protein that is unique to CSF.
D000328:Adult; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid; D001798:Blood Proteins / Q000302:isolation & purification; D002556:Cerebrospinal Fluid Proteins / Q000302:isolation & purification*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007158:Immunologic Techniques; D007938:Leukemia / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009423:Nervous System Neoplasms / Q000134:cerebrospinal fluid
D001798:Blood Proteins; D002556:Cerebrospinal Fluid Proteins