Expression of a transformation-related protein (p53) in the malignant stage of Friend virus-induced diseases.
Stage 1 (pre-malignant) and stage 2 (malignant) cells derived from mice infected with Friend murine leukemia virus or polycythemia-inducing Friend virus complex were examined and compared for the expression of a transformation-related cellular protein, p53. Stage 2 cells were found to express high levels of p53, whereas stage 1 cells did not express detectable levels of this protein. These results indicate that p53 may be a marker for transformed cells present in the second stage of diseases induced by Friend murine leukemia virus or polycythemia-inducing Friend virus complex.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D004900:Erythroblasts / Q000378:metabolism; D004920:Erythropoiesis; D005622:Friend murine leukemia virus / Q000502:physiology*; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood / Q000378:metabolism*; D007942:Leukemia, Experimental / Q000097:blood / Q000378:metabolism*; D051379:Mice; D010750:Phosphoproteins / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53
D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53