[The HLA system and Itsenko-Cushing disease].
The determination of HLA antigens in 54 patients with Icenko-Cushing's disease demonstrated the high rate of AIO antigens (50.7%), B8 (27.3%) and B27 (26.2%) antigens. In the control group, the rate of the same antigens amounted to 17.8, 16.3 and 7.4%, respectively. Specific features were also revealed in the rate of individual HLA haplotypes. The rate of A X IO, B8; A X IO, B27 haplotypes occurring relatively rarely in normal subjects was high in patients with Icenko-Cushing's disease. The high rate of AIO, B8 and B27 antigens may attest to the high risk of the development of Icenko-Cushing's disease in subjects carrying these antigens.
D000328:Adult; D003480:Cushing Syndrome / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen
Sistema HLA i bolezn' Itsenko-Kushinga.