Lactic acidosis and hypoglycemia: experimental evidence to show lactate prevents insulin induced seizures in rats.
A 52-year-old man with lactic acidosis and severe hypoglycemia was fully conscious and alert with a blood sugar of 8 mgs%. We believe normal level of consciousness was maintained due to the presence of hyperlactatemia. We show experimental evidence to suggest that lactate prevents the development of insulin-induced seizures in rats.
D000138:Acidosis / Q000150:complications*; D000818:Animals; D006801:Humans; D007003:Hypoglycemia / Q000150:complications*; D007328:Insulin / Q000009:adverse effects*; D007773:Lactates; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D007328:Insulin; D007773:Lactates