Iopamidol and meglumine diatrizoate: comparison of effects on patient discomfort during aortofemoral arteriography.
Iopamidol was compared with Renografin-60 (meglumine diatrizoate, Squibb) in a controlled, randomized double-blind study of 40 patients undergoing peripheral arteriography for arteriosclerotic occlusive disease to determine which agent caused less discomfort. Each patient was evaluated for objective signs of discomfort and subjective feelings of pain and heat. Monitoring was achieved by multiple physical examinations, chemical tests, electrocardiograms, and intra-arterial pressure recordings. It is concluded that iopamidol is safe and causes significantly less patient discomfort than Renografin-60.
D000792:Angiography / Q000379:methods*; D001161:Arteriosclerosis / Q000000981:diagnostic imaging*; D001794:Blood Pressure; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects*; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004311:Double-Blind Method; D004562:Electrocardiography; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007479:Iopamidol; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D010146:Pain / Q000139:chemically induced; D010808:Physical Examination
D003287:Contrast Media; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; D007479:Iopamidol