title: Nephrotoxicity of parenterally administered cyclosporine after orthotopic liver transplantation.
abstract: The frequency of nephrotoxicity in the absence of identifiable prerenal or postrenal causes within five days of operation in 27 liver transplant recipients was found to be 71% in those treated with i.v. cyclosporine alone, 37.5% with i.m. cyclosporine alone, and 16.7% with prednisolone and azathioprine. Renal failure following i.v. cyclosporine was characterized by an immediate fall in urine output and creatinine clearance with well-preserved tubular function--findings consistent with a reduction in renal blood flow or glomerular filtration rate, or both.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D003524:Cyclosporins; D003404:Creatinine