[Maximal islet cell stimulation following partial duodenopancreatectomy and pancreatic duct occlusion].
Maximum islet cell stimulation with oral glucose loading and intravenous application of glucagon and tolbutamide was done in patients with partial duodenopancreatectomy and occlusion of the pancreatic duct (n = 9), in patients with total duodenopancreatectomy (n = 5) and in healthy test persons (n = 3) in order to test endocrine capacity of the residual pancreas. After partial duodenopancreatectomy and occlusion of the pancreatic duct a clear reduction of the endocrine capacity of the pancreas is found, which can be demonstrated with the statistically significant reduced secretion of insulin and c-peptide. Further deterioration of endocrine pancreatic function then does not take place in the later postoperative course. In patients with total duodenopancreatectomy residual islet cell function could not be demonstrated.
D000328:Adult; D004386:Duodenum / Q000601:surgery*; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010180:Pancreatectomy; D010182:Pancreatic Diseases / Q000601:surgery*; D010183:Pancreatic Ducts / Q000473:pathology*; D011184:Postoperative Period; D013268:Stimulation, Chemical; D014044:Tolbutamide / Q000494:pharmacology
D007328:Insulin; D005934:Glucagon; D014044:Tolbutamide; D005947:Glucose
Maximale Inselzellstimulation nach partieller Duodenopankreatektomie und Pankreasgangocclusion.