Coeliac disease: alpha-1-antitrypsin contents in jejunal mucosa before and after gluten-free diet.
Biopsies of the jejunum from 10 patients suffering from coeliac disease were investigated by an immunohistochemical technique for alpha-I-antitrypsin. The biopsies obtained before treatment did not contain alpha-I-antitrypsin, but after a gluten-free diet alpha-I-antitrypsin was present in Paneth cells in the mucosal crypts. This finding suggests that the absence of alpha-I-antitrypsin in the jejunal mucosa might be a pathogenetic factor in coeliac disease.
D001284:Atrophy; D001706:Biopsy; D002446:Celiac Disease / Q000178:diet therapy / Q000473:pathology*; D005983:Glutens; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D007583:Jejunum / Q000473:pathology*; D008871:Microvilli / Q000648:ultrastructure; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D000515:alpha 1-Antitrypsin; D005983:Glutens