An unusual case of multiple malignancy in an adult.
An adult female is described who, during a clinical course of 25 years, presented malignant tumors of the rectum, breast, uterus and colon. Cytostatics were never administered. Lymphocyte subsets, a variety of lymphocyte and mononuclear cell stimulation assays with mitogens and antigens, DNA repair tests and activity of natural killer cells were normal. Serum leukocytic interleukin-1 activity was slightly elevated. Sister chromatid exchange frequency in peripheral lymphocytes was below the normal range. An explanation for the development of 4 primary malignant neoplasms was not found.
D001943:Breast Neoplasms; D003110:Colonic Neoplasms; D005260:Female; D006801:Humans; D007121:Immunocompetence; D007375:Interleukin-1 / Q000032:analysis; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000276:immunology; D012004:Rectal Neoplasms; D014594:Uterine Neoplasms
D007375:Interleukin-1