title: Antineoplastic effect of the xanthine derivative Trental.
abstract: The xanthine derivative, Trental (pentoxifylline) was found to inhibit several human leukemic and lymphoma cell lines in tissue cultures. Optimal concentrations were less inhibitory for a normal B-lymphocyte cell line then for the neoplastic cell lines. In fact, small concentrations stimulated DNA synthesis in the normal cell line. Trental and beta-interferon appeared to be additive synergists at certain dosages. Possible mechanisms are discussed.
mesh_terms: D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D002051:Burkitt Lymphoma / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D002460:Cell Line; D003131:Combined Modality Therapy; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D007938:Leukemia / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D007945:Leukemia, Lymphoid / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013805:Theobromine / Q000031:analogs & derivatives*
chemical_list: D007370:Interferon Type I; D004247:DNA; D013805:Theobromine; D010431:Pentoxifylline