Localisation of human osteosarcoma by antitumour monoclonal antibody.
Immunoscintigraphy using radioisotope-labelled monoclonal antibody prepared against osteosarcoma 791T cells was used to detect a primary osteosarcoma. The eight-centimetre tumour was detected using rectilinear scintigraphy of 131I-labelled antibodies. Image enhancement was achieved by subtraction of blood-pool radioactivity labelled with technetium-99m. The ratio of tumour to non-tumour uptake of radioactivity (5:1) suggested that antibody targeting of therapeutic agents is feasible.
D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D005260:Female; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000601:surgery; D011877:Radionuclide Imaging; D013382:Subtraction Technique
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes