[Effectiveness of the calcium antagonist nifedipine and the protease inhibitor with plasmin inactivating effect para-aminomethylbenzoic acid on stress-induced bronchial asthma].
In 15 asthmatics (7 females, 8 males, average age 23.3 years) the efficacy of the calcium antagonist nifedipine (Corinfar) and of PAMBA on the exercise-induced asthma was investigated. The patients underwent for 6 minutes a submaximal exercise (80 +/- 5% of the age-related maximum pulse rate) on the bicycle ergometer or by free running. Nifedipine exhibited a highly significant inhibition of the exercise-induced bronchial obstruction (p less than 0.001). Under the PAMBA-medication no significant differences could be stated in comparison to the exercise test without medicament (p greater than 0.5). A standardization of the exercise tests is to be aspired to.
D010129:4-Aminobenzoic Acid / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D062365:Aminobenzoates / Q000627:therapeutic use*; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D000933:Antifibrinolytic Agents; D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D009543:Nifedipine; D010129:4-Aminobenzoic Acid
Untersuchungen über die Wirksamkeit des Kalziumantagonisten Nifedipin und des Proteasen-Inhibitors mit plasmininaktivierender Wirkung Para-Aminomethylbenzoesäure auf das belastungsbedingte Asthma bronchiale.