Possible association of donor blood group A with higher alloantibody responses after renal transplantation.
Donor-specific alloantibody responses were studied in 55 patients receiving their first cadaver kidney transplant, using 51Cr release assays for complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity against two types of donor targets: fibroblasts and lymphoid cells. When patients with pretransplant donor-specific antibody were excluded, the alloantibody responses were significantly more frequent in recipients of blood group A kidneys than in recipients of non-A (P = .004). The association was seen with both lymphocyte and fibroblast target cells, but was stronger when fibroblast targets were used. The association could not be explained adequately by differences in transfusion status or in graft survival between the A and non-A groups. The results suggest that certain types of alloantibody response against the graft are more vigorous in recipients of group A kidneys than in other recipients. Such responses may contribute to the tendency of group A patients to show poorer graft survival in some studies.
D000017:ABO Blood-Group System / Q000276:immunology*; D002102:Cadaver; D003601:Cytotoxicity Tests, Immunologic; D006084:Graft Rejection; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D016030:Kidney Transplantation; D014019:Tissue Donors; D014181:Transplantation Immunology
D000017:ABO Blood-Group System; D007518:Isoantibodies