The significance of the monocyte crossmatch in recipients of living-related HLA identical kidney grafts.
Monocytes and vascular endothelial cells (VEC) carry a "cell specific" antigen system that has been found to play an important role in the pathogenesis of rejection. In a preliminary study utilizing a standard crossmatch technique with the peripheral blood monocyte as target, recipients of HLA identical living-related grafts who had either pretransplant or who developed posttransplant anti-monocyte antibody, had a high incidence of early graft rejection. This larger study of recipients of HLA identical living-related grafts represents the results of 21 patients from 13 separate transplant centers in the United States. Results from this study seem to indicate a positive monocyte crossmatch represented a degree of sensitization toward donor monocyte antigens which lead to a poor clinical course.
D000954:Antigens, Surface / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004727:Endothelium / Q000276:immunology; D006084:Graft Rejection; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D009000:Monocytes / Q000276:immunology*
D000954:Antigens, Surface; D006680:HLA Antigens