Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes.
Hepatic DNA damage was demonstrated by alkaline DNA unwinding/hydroxylapatite batch chromatography in male B6C3F1 mice treated with non-necrogenic doses of 1,2-dichloroethane, 1-bromo-2-chloroethane, and 1,2-dibromoethane. Intraperitoneal administration of 0.5 mmol/kg of 1-bromo-2-chloroethane and 1,2-dibromoethane produced similar levels of DNA damage. A 4-fold higher dose of 1,2-dichloroethane (2.0 mmol/kg) was required to produce a comparable effect.
D000818:Animals; D004247:DNA / Q000235:genetics*; D004980:Ethane / Q000031:analogs & derivatives* / Q000633:toxicity; D015946:Ethylene Dibromide / Q000633:toxicity*; D005025:Ethylene Dichlorides / Q000633:toxicity*; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens; D009929:Organ Size / Q000187:drug effects; D013329:Structure-Activity Relationship
D005025:Ethylene Dichlorides; D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated; D006846:Hydrocarbons, Halogenated; D009153:Mutagens; D015946:Ethylene Dibromide; C024565:ethylene dichloride; D004247:DNA; C039590:1-bromo-2-chloroethane; D004980:Ethane