Rapid action of Qinghaosu and related drugs on incorporation of [3H]isoleucine by Plasmodium falciparum in vitro.
Using the incorporation of [3H]isoleucine into acid-insoluble products as an index of protein-synthetic activity, it was shown that Qinghaosu and two related drugs had a rapid effect on this process in human erythrocytes infected with Plasmodium falciparum in vitro. Inhibition could be seen 1 hr or less after addition of the drugs at concentrations from 5 mumole/1. to 50 nmole/1. It is recommended that the effects of these drugs be studied in cell-free protein-synthetic systems.
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D000077549:Artemether; D037621:Artemisinins; D007532:Isoleucine / Q000378:metabolism*; D007700:Kinetics; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics*; D014176:Protein Biosynthesis / Q000187:drug effects*; D011714:Pyrans / Q000633:toxicity; D012717:Sesquiterpenes / Q000633:toxicity*; D014316:Tritium
D000962:Antimalarials; D037621:Artemisinins; D011714:Pyrans; D012717:Sesquiterpenes; D007532:Isoleucine; D014316:Tritium; C039060:artenimol; C031327:artemisinin; D000077549:Artemether