S-100 protein in tumors of cartilage and bone. An immunohistochemical study.
Using the peroxidase-antiperoxidase (PAP) immunohistochemical method, S-100 protein was found in well-differentiated chondrocytes of chondroma, chondroblastoma, mesenchymal chondrosarcoma, and osteosarcoma. It was not detected in osteoma, osteoblastoma, giant cell tumor, and Ewing's tumor. The presence of S-100 protein in tumorous chondrocytes and chondroblasts suggests that this protein may be a marker of chondrocyte origin and should not be considered a specific marker for nerve tissue.
D000293:Adolescent; D001859:Bone Neoplasms / Q000032:analysis* / Q000601:surgery; D002648:Child; D002804:Chondroblastoma / Q000032:analysis; D002812:Chondroma / Q000032:analysis; D002813:Chondrosarcoma / Q000032:analysis; D005260:Female; D005266:Femoral Neoplasms / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D012516:Osteosarcoma / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis*
D009418:S100 Proteins