A simple field kit for the determination of drug susceptibility in Plasmodium falciparum.
A field kit has been developed which greatly simplifies the performance of the 48-hour in vitro test for drug resistance in Plasmodium falciparum. The kit uses an easily reconstituted lyophilized culture medium, and requires only a fingerprick blood sample. In parallel tests with 13 isolates of P. falciparum in Haiti, the new technique had a success rate equal to that of the previously described method, with comparable results in terms of parasite susceptibility in vitro to chloroquine and pyrimethamine.
D002738:Chloroquine / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000494:pharmacology*; D011933:Reagent Kits, Diagnostic
D011933:Reagent Kits, Diagnostic; D002738:Chloroquine; D011739:Pyrimethamine