Dose requirements of ICI 35,868 (propofol, 'Diprivan') in a new formulation for induction of anaesthesia.
In order to avoid Cremophor-related reactions and reduce the incidence of pain on injection, diisopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side-effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D005217:Fat Emulsions, Intravenous; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage* / Q000494:pharmacology; D015742:Propofol; D012119:Respiration / Q000187:drug effects
D000777:Anesthetics; D005217:Fat Emulsions, Intravenous; D010636:Phenols; D015742:Propofol