title: An evaluation of Econazole, an antifungal agent, for use in quantitative cell culture experiments.
abstract: Econazole, an imidazole derivative with high antifungal activity, was tested for cytotoxicity using five sensitive tests of human cell function in vitro: colony forming efficiency, growth rate, cell cycle distribution of a permanent epithelioid cell line (T-1E), and attachment efficiency and urokinase production by early passage human embryonic kidney cells. None of these endpoints was detectably affected by 1 microgram/ml Econazole in serum containing medium. At 3 micrograms/ml, Econazole reduced slightly the growth rate of T-1E cells but did not detectably affect the other end points.
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D003470:Culture Media; D003584:Cytological Techniques; D004464:Econazole / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007668:Kidney / Q000196:embryology; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D003470:Culture Media; D007093:Imidazoles; D004464:Econazole; D014568:Urokinase-Type Plasminogen Activator