Brainstem auditory-evoked potentials and electrocochleography: comparison of different criteria for the detection of acoustic neuroma and other cerebello-pontine angle tumours.
Different means of identifying the presence of cerebello-pontine angle (CPA) tumours using brainstem auditory-evoked potentials (BAEP) were evaluated. The results from 33 ears affected by tumours were compared with BAEP from 50 normal ears and 23 ears affected by Menière's disease. Measurement of inter-aural latency differences correctly identified 97% of tumours from the normal group, but only 81% of tumours from the Menière group. Comparison of different interwave interval measures showed that the NI to NV interval was the best criterion and correctly identified 90% of the tumours from both the normal and the Menière groups. The use of transtympanic electrocochleography (ECochG) is discussed. Used alone, ECochG was of limited value in detecting CPA tumours except in five out of nine deaf ears where no BAEP were recorded but 'disconnection' action potentials were encountered. By combining BAEP and ECochG, the NI to NV interval could be identified with certainty. Combined BAEP and ECochG recordings were only undertaken when NI was unclear on BAEP recordings or when the ECochG was indicated clinically for the identification of endolymphatic hydrops. In this series, the combined use of BAEP and ECochG resulted in a tumour detection rate of 100% with a false positive rate of zero. The BAEP from the unaffected ear recorded from the ipsilateral and contralateral sides were compared. Significant NI to NV delay was noted, especially on recording from the contralateral side, when there was distortion of the brainstem due to a large tumour. The article concludes with an appendix of six illustrative case reports.
D000328:Adult; D000368:Aged; D001299:Audiometry; D001300:Audiometry, Evoked Response; D001933:Brain Stem / Q000502:physiology; D002528:Cerebellar Neoplasms / Q000175:diagnosis*; D002530:Cerebellopontine Angle; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed