Carbohydrate metabolism in porphyria cutanea tarda.
A study on carbohydrate metabolism (glycaemia and insulinaemia curves during the oral and the intravenous glucose tolerance tests) in 20 porphyria cutanea tarda patients revealed diabetes mellitus in 2 and impaired glucose tolerance in 1 patient, but the carbohydrate tolerance did not differ greatly from that of matched controls. The porphyria cutanea tarda patients, instead, had a significantly exaggerated insulin response, which was more marked in patients with liver disorders. It is proposed that the hyperinsulinism is secondary to the liver damage.
D000328:Adult; D000368:Aged; D050260:Carbohydrate Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007501:Iron / Q000097:blood; D050356:Lipid Metabolism; D008107:Liver Diseases / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011164:Porphyrias / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism*
D007328:Insulin; D007501:Iron; D005947:Glucose