Variations of 1-deoxyglucose(1,5-anhydroglucitol) content in plasma from patients with insulin-dependent diabetes mellitus.
The concentration of 1-deoxyglucose(1,5-anhydroglucitol) in plasma from patients with insulin-dependent diabetes mellitus was measured by gas-liquid chromatography with an all-glass capillary column. Twenty-one plasma samples were obtained from 21 patients before insulin therapy, and 34 more from 13 patients receiving insulin therapy. 1-Deoxyglucose was generally not detectable in plasmas of diabetic patients before they received insulin; it was measurable in the patients who had received insulin, although its concentration was low compared with that of healthy subjects. We therefore suggest that the absence of 1-deoxyglucose in plasma is one of the markers of metabolic states of diabetes, perhaps reflecting a disturbed function of carbohydrate metabolism; its presence in plasma within a normal range may reflect the better control of diabetic patients.
D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002849:Chromatography, Gas; D003837:Deoxy Sugars / Q000097:blood*; D003847:Deoxyglucose / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male
D001786:Blood Glucose; D003837:Deoxy Sugars; D007328:Insulin; D003847:Deoxyglucose