title: Suicidal destruction of cytochrome P-450 during oxidative drug metabolism.
mesh_terms: D000114:Acetylene / Q000494:pharmacology; D000475:Alkenes / Q000494:pharmacology; D000478:Alkylation; D000818:Animals; D001711:Biotransformation; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004347:Drug Interactions; D006418:Heme / Q000096:biosynthesis / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D010084:Oxidation-Reduction; D013379:Substrate Specificity
chemical_list: D000475:Alkenes; D065607:Cytochrome P-450 Enzyme Inhibitors; D007527:Isoenzymes; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D000114:Acetylene