Acquisition of host proteins by the tegument of Schistosoma mansoni recovered from rats.
Four-week-old Schistosoma mansoni collected from experimentally infected albino rats were shown by a fluorescent antibody technique to possess several serum proteins of host origin, including IgM, IgG, complement and red blood cell components. The capacity of these rat-derived worms to acquire and shed host proteins was also demonstrated in vitro with fluoresceinated antibody-labelled worms in the presence of xenogeneic molecules. The implications of these results are discussed in relation to the mechanisms of parasite evasion and "self-cure" phenomenon.
D000818:Animals; D005455:Fluorescent Antibody Technique; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology; D066298:In Vitro Techniques; D009115:Muridae / Q000276:immunology / Q000469:parasitology*; D011817:Rabbits; D051381:Rats; D012550:Schistosoma mansoni / Q000302:isolation & purification*; D012552:Schistosomiasis / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins