Carbamazepine versus diphenylhydantoin in the treatment of myotonia.
A double-blind controlled trial was performed on 6 patients affected with Steinert's disease in order to evaluate the efficacy of two different dosages of diphenylhydantoin (PHT, 200 and 300 mg/day) and carbamazepine (CBZ, 600 and 800 mg/day) on the myotonic afterdischarge. Both dosages of PHT and CBZ induced a significant improvement of myotonia. For PHT a trend towards decreased efficacy is pointed out at toxic or at high dosages.
D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000188:drug therapy*; D010672:Phenytoin / Q000097:blood / Q000627:therapeutic use*
D002220:Carbamazepine; D010672:Phenytoin