Protection against acute, ascending pyelonephritis caused by Escherichia coli in rats, using isolated capsular antigen conjugated to bovine serum albumin.
We found that isolated Escherichia coli K13 antigen conjugated to bovine serum albumin, in contrast to isolated, non-conjugated K13, was highly immunogenic and induced protection against acute pyelonephritis caused by E. coli O6K13H1 in rats.
D000208:Acute Disease; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface; D004927:Escherichia coli Infections / Q000276:immunology* / Q000517:prevention & control; D005260:Female; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011704:Pyelonephritis / Q000276:immunology* / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000276:immunology*
D000941:Antigens; D000942:Antigens, Bacterial; D000954:Antigens, Surface; C030659:K antigens; D011135:Polysaccharides, Bacterial; D012710:Serum Albumin, Bovine