Neuronal and astrocytic differentiation in human neuroepithelial neoplasms. An immunohistochemical study.
Neuroepithelial neoplasms of childhood were examined immunohistochemically using antibodies against a neurofilament polypeptide and glial fibrillary acidic protein. Ninety-one cases, including 11 controls, were examined. Positively reacting cells, indicating neuronal and glial differentiation, were found in 59 of the 80 tumors. The study supports a neuroepithelial origin for medulloblastomas, central neuroblastomas, and primitive neuroectodermal tumors of childhood. The results also indicate that only a small number of the tumor cells differentiate along either neuronal or glial cell lines.
D001254:Astrocytoma / Q000378:metabolism / Q000648:ultrastructure*; D001932:Brain Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D002454:Cell Differentiation; D002648:Child; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008527:Medulloblastoma / Q000378:metabolism / Q000648:ultrastructure; D009447:Neuroblastoma / Q000378:metabolism / Q000648:ultrastructure; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000378:metabolism / Q000648:ultrastructure*; D010871:Pinealoma / Q000378:metabolism / Q000648:ultrastructure