Damage to the surface of the small intestinal villus: an objective scale of assessment of the effects of single and fractionated radiation doses.
Scanning electron microscopy has been used to compare damage to mouse small intestinal mucosa after irradiation with different doses of photons and neutrons. Various stages of the collapse of villous structure seen after radiation include the production of conical and rudimentary villi and a flattened mucosa. A scale is proposed to relate radiation to villous damage. Points from this scale are taken to produce comparative ratios for equivalent damage produced by different radiation conditions. RBE values are quoted for neutron. X and gamma radiation given as single or fractionated irradiation doses and as whole or partial body irradiation. The relationship between the stroma in intravillous pegs and that of the pericryptal compartment is explored.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D007413:Intestinal Mucosa / Q000528:radiation effects* / Q000648:ultrastructure; D007421:Intestine, Small / Q000528:radiation effects* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000528:radiation effects / Q000648:ultrastructure; D009502:Neutrons; D011829:Radiation Dosage; D013997:Time Factors; D014916:Whole-Body Irradiation