title: Mechanism of reduced maximum expiratory flow in methacholine-induced bronchoconstriction in dogs.
abstract: Airway sites of flow limitation ["choke points" (CP)] were identified during forced deflation in open-chest dogs before (C) and after (B) bronchoconstriction was produced by nebulizing a solution of methacholine chloride into their airways. CP were identified in two respective groups. In group I (n = 8) a retrograde catheter was used to locate CP and in the other a Pitot static tube (group II, n = 5), CP were identified at multiple lung volumes (VL) over the lower one-half of total lung capacity. Both groups showed similar findings at each condition. At B, corresponding values of maximum expiratory flow (Vmax) at each VL decreased to about 10% of those at C. Movement of CP relative to their original location varied at each VL and, especially at the lower VL, showed little peripheral movement. In group I, equal pressure points were also measured and were found to move peripherally at all the measured VL. In group II, cross-sectional area (A*) and airway compliance (K) at CP were estimated. During bronchoconstriction, A* decreased at the respective VL, and airways became less compliant. The reduction in Vmax could be explained in terms of changes in A* and K as described by wave-speed theory, and Vmax decreased because A* decreased. The decrease in A* was related in part to an increase in viscous pressure losses that reduced total pressure at CP and also in part to a change in the pressure-area behavior of bronchi at CP. Their relative effects on reducing A* and Vmax were examined.
mesh_terms: D000402:Airway Obstruction / Q000209:etiology; D000403:Airway Resistance; D000818:Animals; D001696:Biomechanical Phenomena; D001986:Bronchial Spasm / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D004285:Dogs; D005540:Forced Expiratory Flow Rates; D008176:Lung Volume Measurements; D008450:Maximal Midexpiratory Flow Rate; D016210:Methacholine Chloride; D008688:Methacholine Compounds
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride