Half-life time and control frequency of vitamin K-dependent Coagulation factors. Theoretical considerations on the place of factor VII in the control of oral anticoagulation therapy.
A short review about the place of coagulation factor VII in the initial phase of blood coagulation is given. A theoretical model describing the relationship between the half-life times of vitamin K-dependent coagulation factors and the control frequency of oral anti-coagulation therapy is presented. The constraints that control frequency imposes on the type of determination to be carried out are discussed.
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D002417:Cattle; D005164:Factor IX / Q000096:biosynthesis; D015949:Factor IXa; D005167:Factor VII / Q000032:analysis* / Q000096:biosynthesis / Q000502:physiology; D015942:Factor VIIa; D005170:Factor X / Q000096:biosynthesis / Q000502:physiology; D015951:Factor Xa; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D014812:Vitamin K / Q000097:blood*
D000925:Anticoagulants; D014812:Vitamin K; D005167:Factor VII; D005164:Factor IX; D005170:Factor X; D015942:Factor VIIa; D015949:Factor IXa; D015951:Factor Xa