title: [Treatment of duodenal ulcer with synthetic depot secretin - a double-blind study].
abstract: 63 inpatients with duodenal ulcer disease were treated with either depot-secretin or placebo. Two different secretin-regimens were used. In group I 18 patients were given secretin twice daily. 11 ulcers from a total of 19 ulcers healed within 3 weeks. In group II 23 patients were given secretin once daily. 21 out of 28 ulcers healed within 3 weeks. In the placebo-treated group 24 ulcers were observed in 22 patients. Of these 15 healed within 3 weeks. There was no statistical difference in the healing rate between the 3 groups. However, depot-secretin significantly improved typical symptoms. Analgetics were used less frequently. Serious side effects did not occur.
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D012633:Secretin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D012633:Secretin
vernacular_title: Die Behandlung des Ulcus duodeni mit synthetischem Depot-Sekretin - eine Doppelblindstudie.