Theoretical study on conformation-related activity of hypoglycemic sulfonylureas.
Theoretical conformational analysis has been carried out for different hypoglycemic sulfonylurea -Ca complexes. The formed complex has an hydrophobic external surface and a low amphiphilic character. Our results suggest that Calcium may effectively be transported across membranes of Langerhans B cells and that the different biological potencies of the drugs may be due in part to the shape of the different complexes.
D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D013453:Sulfonylurea Compounds / Q000494:pharmacology*
D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds