[Evaluation of the effects of active rubella vaccination. Comparative studies of the evaluation of seroconversion using the ELISA technic and the hemagglutination inhibition test].
31 women were vaccinated with attenuated rubella-virus (RV) strains. According to the prevaccinal antibody status they were grouped as follows: I: HIT 1: less than 10, RV-specific IgG 1: less than 20; II: HIT 1: less than 10, RV-specific IgG 1: greater than 20; III: HIT 1: greater than or equal to 10, RV-specific IgG 1: greater than 30. The postvaccinal geometric mean titers for RV-ELISA-IgG were somewhat higher in group II compared to group I, eventually because of a weak booster effect based on low level prevaccinal RV-antibody titers--but the difference is not significant for 5%. The difference between RV-ELISA-IgG in group II and group I is significant. Within group II there is a low titer rise upon vaccination although elevated prevaccinal titers were already present. The quotient "RV-ELISA-IgG-titer: HIT-titer" is in the range of greater than or equal to 23:1 for the postvaccinal period (8-10 weeks after vaccination) compared to about 8:1 resp. in stationary sera of reconvalescent individuals. These quotients could be helpful for interpretation of suspicious elevated titers during pregnancy.
D000914:Antibodies, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D011247:Pregnancy; D012411:Rubella Vaccine / Q000494:pharmacology*; D012412:Rubella virus / Q000276:immunology*
D000914:Antibodies, Viral; D012411:Rubella Vaccine
Zur Beurteilung des Impferfolgs nach aktiver Röteln-Impfung. Vergleichende Untersuchung zur Bewertung der Serokonversion mittels ELISA-Technik und Hämagglutinationshemmtest.