[Varicella-zoster virus infections in the immunosuppressed child. Treatment with Acyclovir and controls].
Sixty minutes intravenous infusions of Acyclovir were given at 5 to 10 mg/kg 3 times daily for 6 to 11 days in 20 immunodeficient children with varicella (9 cases) and herpes zoster (11 cases) in a controlled open study. Twelve patients had a life-threatening illness. All patients who received therapy before the first 4 days had a more rapid cessation of new vesicles formation and more rapid scarring. Fourteen controlled children had accelerated clearance of viral antigens from vesicles. In 19 cases, virus was no longer isolated after the 3rd day. Eighteen patients recovered within 6 to 10 days. No relapse of varicella zoster virus infections had been observed 1 to 18 months after the end of treatment. Two children with varicellous interstitial pneumonia died 8 and 32 days after the end of treatment. In 3 cases, zoster pains reappeared 8 days after Acyclovir therapy was stopped. The drug was well-tolerated, but control of renal functions is necessary.
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000956:Antigens, Viral / Q000032:analysis; D002644:Chickenpox / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007108:Immune Tolerance; D007263:Infusions, Parenteral; D007938:Leukemia / Q000150:complications; D008223:Lymphoma / Q000150:complications; D008297:Male; D009369:Neoplasms / Q000150:complications
D000956:Antigens, Viral; D000212:Acyclovir
Les infections à virus varicelle-zoster chez l'enfant immunodéprimé. Traitement par Acyclovir et contrôles.