title: Chronoeffectiveness of indomethacin in four patients suffering from an evolutive osteoarthritis of hip or knee.
abstract: During a 4-week span 4 patients suffering from an evolutive osteoarthritis ingested 3 pills/day at fixed clock hours: 0800, 1200 and 2000. One of the weeks was devoted to a (placebo) control span. During the other weeks only one of the 3 ingested pills contained the daily dose of 50 mg indomethacin. This latter, when taken at 1200, had the maximum effect on self-rated pain (decrease of 60% of the 24-h mean, p less than 0.0005) and self-rated stiffness (decrease of 54% of M, p less than 0.005) as well as on mean oral temperature.
mesh_terms: D000368:Aged; D001831:Body Temperature; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D005260:Female; D006621:Hip Joint / Q000503:physiopathology; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007719:Knee Joint / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology; D010146:Pain / Q000503:physiopathology; D012647:Self-Assessment; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D007213:Indomethacin