Effects of concomitant pentazocine and tripelennamine on brain-stimulation reward.
Reinforcing thresholds for self-stimulation behavior to the medial forebrain bundle were determined in rats by means of a rate-free psychophysical method. The acute administration of either pentazocine or tripelennamine caused a small but significant lowering of the reward threshold. Combined administration of an ineffective dose of tripelennamine with various doses of pentazocine resulted in a potentiation of this lowering effect. These results suggest that the widespread abuse of the combination of pentazocine and tripelennamine may be due to a pharmacologic potentiation rather than just a summation of their two effects.
D000818:Animals; D007026:Hypothalamic Area, Lateral / Q000187:drug effects*; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects*; D010423:Pentazocine / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D012653:Self Stimulation / Q000187:drug effects*; D014309:Tripelennamine / Q000494:pharmacology*
D014309:Tripelennamine; D010423:Pentazocine