Prevention of congenital malformations in infants of insulin-dependent diabetic mothers.
From April 1977 to April 1981, 420 deliveries of infants of insulin-dependent diabetic women were performed in our department. Of the infants delivered, 23 had congenital malformations (5.5%). The malformation rate was 1.4% for infants of 420 nondiabetic women. Strict metabolic control was begun after 8 wk gestation in 292 of the diabetic women who delivered 22 infants with congenital malformations (7.5%). Intensive treatment was begun before conception in 128 diabetic women planning pregnancy. There was only one malformation in infants of this group (0.8%), a significant reduction from the anomaly rate in the late registrants (X2 = 7.84; P less than 0.01). These observations indicate that reasonable metabolic control started before conception and continued during the first weeks of pregnancy can prevent malformations in infants of diabetic mothers.
D000013:Congenital Abnormalities / Q000453:epidemiology / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000628:therapy*; D003927:Diet, Diabetic; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000628:therapy*; D007231:Infant, Newborn; D007328:Insulin / Q000008:administration & dosage / Q000172:deficiency; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011254:Pregnancy in Diabetics / Q000628:therapy*; D011295:Prenatal Care / Q000379:methods
D007328:Insulin