Cytokines and the chronic inflammation of rheumatic disease. II. The presence of interleukin-2 in synovial fluids.
Sera and synovial fluids from patients with a variety of rheumatic diseases were assayed for interleukin-2 (IL-2) activity in a system utilizing the proliferative response of cultured human phytohaemagglutinin (PHA) T cell blasts. The synovial fluids from 14 rheumatoid arthritis, eight ankylosing spondylitis, three psoriatic arthritis and 11 osteoarthritis patients, all showed IL-2 activity. The amounts of IL-2 present in the fluids from different diseases were compared and ranged from 4.2 to 140.0 units/ml.
D001172:Arthritis, Rheumatoid / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000032:analysis*; D008213:Lymphocyte Activation; D010003:Osteoarthritis / Q000276:immunology; D012216:Rheumatic Diseases / Q000276:immunology*; D013167:Spondylitis, Ankylosing / Q000276:immunology; D013582:Synovial Fluid / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D007376:Interleukin-2; D013936:Thymidine