Coronary artery bypass in hereditary factor XI deficiency.
Hereditary factor XI deficiency is a disorder of coagulation that has been associated with postoperative bleeding. Because cardiopulmonary bypass itself induces transient abnormalities in hemostasis, the patient with factor XI deficiency could be at increased risk for bleeding after cardiac surgical procedures. We report the successful management of a 61-year-old man with hereditary factor XI deficiency who had coronary artery bypass. Treatment with low-dose aspirin, begun 24 hours postoperatively for graft patency, was well tolerated. Once recognized and aggressively treated, factor XI deficiency does not appear to be a contraindication to potentially life-saving procedures like coronary revascularization.
D001803:Blood Transfusion; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000601:surgery*; D005173:Factor XI Deficiency / Q000097:blood / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010949:Plasma; D011184:Postoperative Period