[Basic studies of cefmenoxime].
Blood levels and urinary excretion of cefmenoxime (CMX) in children of 8 to 13 years old who received 50 mg/kg of CMX by one shot intravenous injection or 1-hour drip infusion were evaluated. One shot intravenous injection (1) Blood levels--The mean blood levels in 2 cases by intravenous injection were 125.0 +/- 24.0, 56.8 +/- 10.0, 17.8 +/- 6.2, 2.2 +/- 0.7 and 0.4 +/- 0.2 micrograms/ml, after 1/2, 1, 2, 4 and 6 hours, respectively. The mean biological half-life was approximately 0.7 hour. (2) Urinary excretion--The average urinary excretion rate in 2 cases were 57.8, 63.9 and 64.1% after 2, 4 and 6 hours, respectively. 1-hour drip infusion (1) Blood levels--The mean blood levels in 2 cases by drip infusion were 115.5 +/- 0.5, 29.05 +/- 0.25, 5.0 +/- 0.8 and 1.15 +/- 0.45 micrograms/ml, immediately after the completion of infusion, after 1, 3 and 5 hours, respectively. The mean biological half-life after drip infusion was approximately 0.8 hour. (2) Urinary excretion--The average urinary excretion rate in 2 cases were 42.2, 55.5 and 56.5% after 2, 4 and 6 hours, respectively. On the basis of these results, it was concluded that CMX was excreted relatively rapidly in a massive dose of 50 mg/kg a time.
D000293:Adolescent; D000367:Age Factors; D015281:Cefmenoxime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D002648:Child; D005260:Female; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008297:Male
D015281:Cefmenoxime; D002439:Cefotaxime