title: Mouse mammary tumor virus DNA methylation: tissue-specific variation.
abstract: Mouse mammary tumor virus-specific DNA sequences endogenous to the BALB/c mouse are shown to exhibit variable levels of methylation in a tissue-specific manner. In DNA from both lactating mammary gland and spleen, MMTV-specific sequences were hypomethylated at specific HpaII and HhaI sites. These variably methylated sites were found in the terminal repetitive sequences of the endogenous viral genomes. The specific hypomethylation of a HpaII site in Mtv-9 is associated with expression of a 1.6 kb transcript in the lactating mammary gland.
mesh_terms: D044503:5-Methylcytosine; D000818:Animals; D001483:Base Sequence; D003596:Cytosine / Q000031:analogs & derivatives* / Q000032:analysis; D004262:DNA Restriction Enzymes; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D005260:Female; D005814:Genes, Viral; D007774:Lactation; D008321:Mammary Glands, Animal / Q000382:microbiology*; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D008745:Methylation; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D012367:RNA, Viral / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D013154:Spleen / Q000382:microbiology*; D014158:Transcription, Genetic
chemical_list: D004279:DNA, Viral; D012367:RNA, Viral; D044503:5-Methylcytosine; D003596:Cytosine; D004262:DNA Restriction Enzymes