title: Conditionally lethal tubulin mutations of Aspergillus nidulans.
abstract: Conditionally lethal tubulin mutants are becoming an important tool for studying microtubule structure and function. In the filamentous fungus Aspergillus nidulans it has been possible to isolate heat-sensitive beta-tubulin mutations by isolating mutants resistant to the anti-microtubule agent benomyl and screening these mutants for heat sensitivity. It has also been possible to isolate alpha-tubulin mutations, new beta-tubulin mutations and mutations in other genes whose products are likely to interact with beta tubulin as revertants of heat-sensitive beta-tubulin mutations.
mesh_terms: D001233:Aspergillus nidulans / Q000235:genetics* / Q000378:metabolism; D006358:Hot Temperature; D008869:Microtubule-Associated Proteins; D008870:Microtubules; D009154:Mutation; D011506:Proteins / Q000378:metabolism; D013489:Suppression, Genetic; D014404:Tubulin / Q000235:genetics*
chemical_list: D008869:Microtubule-Associated Proteins; D011506:Proteins; D014404:Tubulin