Contrast agent-induced thrombophlebitis following leg phlebography: meglumine loxaglate versus meglumine lothalamate.
A comparison was made of the incidence of venous thrombophlebitis resulting from the use of a high-osmolality contrast medium (Conray 60%, meglumine ioxaglate) and a low-osmolality contrast medium (Hexabrix 59%, meglumine iothalamate). In 30 patients with varicose veins, Conray was injected into one leg and Hexabrix into the other. The incidence of thrombophlebitis was then determined using the iodine-125 fibrinogen uptake test in a prospective, randomized, double-blind study. There was significantly less thrombophlebitis with Hexabrix than with Conray and the authors conclude that Hexabrix is safer for phlebography. Hexabrix is also stable in solution, only slightly more expensive than Conray, and one fifth the cost of metrizamide.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D005340:Fibrinogen; D006801:Humans; D007457:Iodine Radioisotopes; D007463:Iodobenzoates / Q000009:adverse effects*; D007482:Iothalamate Meglumine / Q000009:adverse effects*; D007485:Ioxaglic Acid; D007866:Leg / Q000098:blood supply / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D014283:Triiodobenzoic Acids / Q000009:adverse effects*; D014648:Varicose Veins / Q000150:complications / Q000000981:diagnostic imaging
D003287:Contrast Media; D007457:Iodine Radioisotopes; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D005340:Fibrinogen; D007482:Iothalamate Meglumine; D007485:Ioxaglic Acid