Activation of renin-angiotensin system in maintenance of high blood pressure in uncomplicated pheochromocytoma--a case report.
In a patient with an uncomplicated pheochromocytoma, we observed high basal value of plasma renin activity (PRA), 16.2 ng/ml/h, and a remarkable elevation in PRA from 18.2 to 90.4 ng/ml/h and concomitant blood pressure reduction following a single oral administration of 25 mg of captopril. The response was same as that observed in renovascular hypertensives, and disappeared during the period of alpha-, beta-blocker administration or after the surgery. Basal PRA also returned to low normal level. The renin-angiotensin (R-A) system probably had a role in the maintenance of high blood pressure. The mechanism of the activation of the R-A system was thought to be renal vasoconstriction due to excessive circulating catecholamines.
D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D010673:Pheochromocytoma / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D011392:Proline / Q000031:analogs & derivatives*; D012084:Renin-Angiotensin System / Q000187:drug effects*; D013268:Stimulation, Chemical
D011392:Proline; D002216:Captopril