Effect of age and glucocorticoid administration on the proteolytic activity of gastric mucosa: a comparative study in the young rat, calf and piglet.
The proteolytic activity of gastric mucosa markedly increased from 2 to 4 wk of age in rats and from birth to 8 wk in pigs. In calves it was at adult level at birth, then decreased until d 14 and remained at a relatively low level up to d 56 of age. Early postnatal glucocorticoid injections increased (P less than .05) the proteolytic activity of gastric mucosa in rats, decreased (P less than .05) the abomasal proteolytic activity in calves and had no significant effect in pigs. The high levels of proteolytic activity observed in the rat at earlier ages after glucocorticoid treatment suggested a precocious maturation of the gastric mucosa. Injections of different doses of hydrocortisone acetate and dexamethasone to calves and rats indicated that proteolytic activity of gastric mucosa is only sensitive to high doses (i.e., nonphysiological) of glucocorticoids. The response of gastric mucosa to glucocorticoid injections depended on the animal's age; maximum response was obtained in the early postnatal period while minimal response was observed after weaning.
D000018:Abomasum; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002417:Cattle / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology*; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013552:Swine / Q000378:metabolism*
C021650:hydrocortisone acetate; D003907:Dexamethasone; D010447:Peptide Hydrolases; D006854:Hydrocortisone