Pathogenicity of the hyphae of Filobasidiella neoformans.
The pathogenicity of the purified hyphae of Filobasidiella neoformans was determined. The hyphal particles were inoculated into white Swiss female mice via the intracranial and intravenous route. Upon autopsy, infection was seen with as few as 25 hyphal elements. The brain, liver, and spleen were examined culturally and the brain examined histologically to prove the pathogenicity of the purified hyphae.
D000818:Animals; D001921:Brain / Q000382:microbiology; D003454:Cryptococcus / Q000472:pathogenicity*; D003455:Cryptococcus neoformans / Q000254:growth & development / Q000472:pathogenicity*; D005260:Female; D008099:Liver / Q000382:microbiology; D051379:Mice; D013154:Spleen / Q000382:microbiology