title: A double-blind cross-over study of the effect of ketotifen in urticaria pigmentosa.
abstract: 10 adult patients with symptomatic urticaria pigmentosa were treated with ketotifen versus placebo in a double-blind cross-over study. A highly significant reduction of the daily symptom scores for pruritus and whealing was found with 2 mg ketotifen daily per os, and, compared to oral disodium cromoglycate, ketotifen was much more effective. Tiredness was the only side effect noted in 40% of the patients, and a transient worsening of symptoms was noted after discontinuation of the drug.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D014582:Urticaria Pigmentosa / Q000188:drug therapy*
chemical_list: D007665:Ketotifen