Oxolinic acid--trimethoprim combination: effects on DNA synthesis and on viability of Escherichia coli.
The synergistic bactericidal effect of the oxolinic acid-trimethoprim combination has been confirmed on an exponentially growing strain of Escherichia coli, and is paralleled by a synergistic inhibition of 14C-uracil incorporation into the bacterial DNA. These data provide experimental support for the postulate that the synergistic effect of quinolone-trimethoprim combinations, observed both in vitro and in vivo, is due to a complementary blockade of bacterial DNA synthesis.
D004269:DNA, Bacterial / Q000096:biosynthesis*; D004338:Drug Combinations; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D010093:Oxolinic Acid / Q000494:pharmacology*; D013997:Time Factors; D014295:Trimethoprim / Q000378:metabolism*
D004269:DNA, Bacterial; D004338:Drug Combinations; D014295:Trimethoprim; D010093:Oxolinic Acid