Effects of aging on the in vitro response of human lymphocytes to interleukin-2.
Effects of aging on the in vitro responses of human peripheral blood lymphocytes (PBL) to interleukin-2 (IL-2, T-cell growth factor) were studied. Aged PBL showed a significantly lower response to phytohemagglutinin (PHA) than young PBL. On the other hand, proliferative responses to exogenous IL-2 showed by aged PBL were found to be in same extent as those of young PBL. In addition, cultured lymphoid cells propagated in IL-2 (CLC-IL-2) derived from both young and aged PBL showed a strong cytotoxic reactivity against the natural killer (NK) sensitive target K562.
D000328:Adult; D000368:Aged; D000375:Aging; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism
D007376:Interleukin-2; D010835:Phytohemagglutinins; D013936:Thymidine