[Inhibition of the growth of a syngeneic weakly immunogenic tumor in mice resulting from exposures affecting T lymphocyte activity].
Adult BALB/c mice were thymectomized, lethally irradiated and reconstituted with cells of syngeneic embryonic liver (B-mice). The growth of the syngeneic low-immunogenic tumor of spontaneous origin (Acatol) was strongly inhibited in B-mice as compared to that in intact recipients. The transplantation of the tumor to adult-thymectomized hosts 3 months after operation also resulted in marked retardation of tumor growth as compared to intact or sham-operated animals. The same effect was observed in mice preimmunized with spleen cells from tumor-bearers but not from intact donors. It is inferred that BALB/c mice possess strong non-specific factors of tumor resistance. However, they are actively suppressed by the mature immune system. Apparently, tumor cells, regardless of low immunogeneity are antigenic enough for the syngeneic host and induce a series of immune reactions, bringing about activation of T suppressors. It is assumed that attempts at immunizing a tumor host with autochthonous T suppressors might lead to a promising approach to cancer immunotherapy.
D000230:Adenocarcinoma / Q000276:immunology*; D000818:Animals; D007114:Immunization; D016031:Liver Transplantation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D013154:Spleen / Q000637:transplantation; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D013934:Thymectomy; D014181:Transplantation Immunology / Q000528:radiation effects; D014185:Transplantation, Isogeneic
Tormozhenie rosta singennoĭ slaboimmunogennoĭ opukholi u mysheĭ v rezul'tate vozdeĭstviĭ, vliiaiushchikh na aktivnost' T-limfotsitov.