The effect of troleandomycin and methylprednisolone alone and in combination on bronchial sensitivity to methacholine.
The effect singly and in combination of methylprednisolone and troleandomycin (TAO) on methacholine sensitivity was studied in eight mildly asthmatic patients who did not require regular bronchodilator therapy. Neither drug alone nor in combination significantly altered the bronchial reactivity to methacholine.
D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000009:adverse effects*; D008775:Methylprednisolone / Q000627:therapeutic use*; D010919:Placebos; D012129:Respiratory Function Tests; D014217:Troleandomycin / Q000627:therapeutic use*
D008688:Methacholine Compounds; D010919:Placebos; D016210:Methacholine Chloride; D014217:Troleandomycin; D008775:Methylprednisolone