[Biopharmaceutical studies on phospholipid liposomes as carriers for the oral administration of insulin].
Insulin-loaded phospholipid liposomes containing 125I-insulin as an indicator were orally administered to mice. The activity distribution in the organism was followed as a function of the time elapsed after application. Biphasic evacuation of the stomach was followed by rapid absorption from the intestine, and the distribution in the blood and body periphery. Precipitation by trichloroacetic acid showed that 20-25% of the indicator were intact or macromolecularly bounded. Actual degradation processes manifest themselves in a rapid increase of the activity in the thyroid gland and the excreta. Furthermore, the effect of an increase in deoxycholate concentration on the inclusion was studied in vitro; it was found that insulin is largely released above a critical concentration coefficient.
D000818:Animals; D001702:Biopharmaceutics; D003840:Deoxycholic Acid; D007328:Insulin / Q000008:administration & dosage* / Q000378:metabolism; D007457:Iodine Radioisotopes; D008081:Liposomes / Q000008:administration & dosage; D051379:Mice; D010743:Phospholipids
D007328:Insulin; D007457:Iodine Radioisotopes; D008081:Liposomes; D010743:Phospholipids; D003840:Deoxycholic Acid
Biopharmazeutische Untersuchungen an Phospholipid-Liposomen als Träger zur oralen Applikation von Insulin.