Urokinase therapy for thrombosis of tricuspid prosthetic valve.
A 16-month-old child was born with pulmonic stenosis and a hypoplastic right ventricle. After palliative procedures, the patient began having signs of tricuspid insufficiency and stenosis necessitating a tricuspid valve replacement. A St. Jude Medical valve was implanted. While the child was on aspirin therapy, thrombus formation resulted in valve dysfunction. This thrombus was successfully dissolved with urokinase infusion, and normal valve function was restored.
D001780:Blood Coagulation Tests; D010450:Endopeptidases / Q000627:therapeutic use*; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D013927:Thrombosis / Q000209:etiology / Q000628:therapy*; D014261:Tricuspid Valve; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator