An open assessment of 0.1% dithranol in a 17% urea base ('Psoradrate' 0.1%) in the treatment of psoriasis of children.
An open study was carried out in 41 children with mild to moderate psoriasis to assess the effectiveness and tolerance of treatment with a 0.1% dithranol plus 17% urea preparation applied twice daily. Thirty-four patients completed 6-weeks' treatment and 8 of them continued for a further 4 to 6 weeks. The results showed considerable improvement in lesions and, in general, the preparation was well-tolerated and considered to be highly or very acceptable by the majority of the patients. Only 3 patients had to be withdrawn for treatment-related reasons which involved soreness or burning of the skin due to the dithranol.
D000287:Administration, Topical; D000293:Adolescent; D000873:Anthracenes / Q000008:administration & dosage*; D000875:Anthralin / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy*; D013997:Time Factors; D014508:Urea / Q000008:administration & dosage*
D000873:Anthracenes; D009824:Ointments; D014508:Urea; D000875:Anthralin