[In vitro activity of azthreonam on hospital Gram-negative bacilli. Results of a multicenter study].
This work reports a multicenter study of antibacterial activity of azthreonam, a new antibacterial agent of the monobactam group, on Gram negative rods. Enterobacteriaceae are very sensitive to azthreonam (modal MIC: 0,06 micrograms/ml); some strains have higher MIC greater than or equal to 8 micrograms/ml, particularly among Enterobacter, Serratia and Citrobacter. Azthreonam has a good activity on Pseudomonas aeruginosa: 90% of the strains are inhibited by 8 micrograms/ml or less. Acinetobacter are less sensitive with a modal MIC of 32 micrograms/ml. Haemophilus are inhibited by low concentrations, 0,06 to 0,12 micrograms/ml usually.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam; D001419:Bacteria / Q000187:drug effects*; D004755:Enterobacteriaceae / Q000187:drug effects; D005602:France; D006761:Hospitals; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D001398:Aztreonam
Activité in vitro de l'azthréonam sur les bacilles Gram négatifs hospitaliers. Résultats d'une étude multicentrique.