[An experimental model of osteoarthritis. I. Induction and ultrastructural study].
Starting from Bentley's works [2], we elaborated an experimental model of arthrosis easy to use, providing reproducibility of effects and showing the same development as the human disease, but within a far shorter time. Papain injection induced a quick, high loss in proteoglycans. A rapid, localised chondrocyte reaction in the middle layer of the support area was noted. In this area, cells rapidly showed hyperactivity signs and a crown of microfibers taking the amyloid tissue-specific staining was seen around them. The building of such crowns might result from a discrepancy between collagen and proteoglycan secretion inducing a modification in their inter-relations. We also noticed binucleate cells, someones being in process of division, which might be the beginning of clones.
D000818:Animals; D002358:Cartilage, Articular / Q000648:ultrastructure*; D003545:Cysteine; D004195:Disease Models, Animal; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D010003:Osteoarthritis / Q000139:chemically induced / Q000473:pathology*; D010206:Papain; D011817:Rabbits; D013583:Synovial Membrane / Q000473:pathology; D013997:Time Factors
D010206:Papain; D003545:Cysteine
Etude d'un modèle expérimental d'arthrose. I.--Induction et étude ultrastructurale.