title: Effect of different intraoperative fluid regimens on circulating metabolites and insulin during abdominal surgery.
abstract: The effects of infusion i.v. of 0.9% sodium chloride solution, Hartmann's and 5% dextrose solution on the concentrations of circulating metabolites and insulin were compared in patients undergoing cholecystectomy. Hartmann's solution had a similar effect on the metabolic response to 0.9% sodium chloride solution, but the use of 5% dextrose was associated with an exacerbation of the hyperglycaemic response to surgery. Plasma insulin concentrations increased significantly in the group receiving 5% dextrose showing that the usual suppression of insulin during abdominal surgery can be overcome by a strong glycaemic stimulus.
mesh_terms: D000328:Adult; D001769:Blood / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D002763:Cholecystectomy; D005260:Female; D005440:Fluid Therapy; D005947:Glucose / Q000008:administration & dosage; D005990:Glycerol / Q000097:blood; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000097:blood*; D007432:Intraoperative Period; D007552:Isotonic Solutions / Q000008:administration & dosage; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D011773:Pyruvates / Q000097:blood; D000077325:Ringer's Lactate; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007552:Isotonic Solutions; D007773:Lactates; D011773:Pyruvates; D000077325:Ringer's Lactate; D012965:Sodium Chloride; D005947:Glucose; D005990:Glycerol