Membranous glomerulopathy and nephrotic syndrome after captopril therapy.
Membranous glomerulopathy and proteinuria have occurred in patients receiving captopril for hypertension. In this case of captopril-associated nephrotic syndrome, a pretreatment biopsy specimen showed normal histologic appearance and glomerular ultrastructure. A posttreatment biopsy specimen showed membranous glomerulopathy. It seems likely that captopril caused the membraneous glomerulopathy.
D001706:Biopsy; D002216:Captopril / Q000009:adverse effects*; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000139:chemically induced*; D011392:Proline / Q000031:analogs & derivatives*; D011507:Proteinuria / Q000139:chemically induced
D011392:Proline; D002216:Captopril