Comparative study of different urokinase preparations.
Three different urokinase preparations were assayed for amidolytic and plasminogen activator activity. It was found that the preparation with the least amidolytic activity displayed a significantly greater plasminogen activator activity than the others. These results suggest that this particular preparation may be more effective clinically and that the use of assay systems for the comparison of urokinase preparations must be treated with caution.
D010450:Endopeptidases / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D009842:Oligopeptides; D010960:Plasminogen Activators / Q000378:metabolism*; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
D009842:Oligopeptides; C028190:5-oxo-prolyl-glycyl-arginine-4-nitroanilide; D010450:Endopeptidases; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator