title: [New derivatives of benzopyran-4-one with analgesic, anti-inflammatory and antiplatelet clumping activity].
abstract: A series of 35 new derivatives of 3-benzylidene benzopyran-4-one carboxylic acid was synthesized; their antiinflammatory and analgesic activities were investigated and compared with those of acetylsalicylic acid, phenylbutazone, ketoprofene and glafenine. Among these compounds, four were found to be more potent than the references compounds in tests of antiinflammatory and analgesic activity. Seven compounds were tested on rat blood platelet aggregation induced by ADP. From these tests, HD-039, HD-041, HD-044 and HD-049 appear to be promising antiinflammatory, analgesic and anticlotting agents, although this original series shows little structural analogy with classical non-steroidal antiinflammatory agents.
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D001792:Blood Platelets / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones
vernacular_title: Nouveaux dérivés de la benzopyrannone-4, à activités analgésique, anti-inflammatoire et antiagrégante plaquettaire.