[Role of a change in oxygen concentration in modifying in vitro reproductive cell death. 3. Modification of radiosensitivity by compounds reducing oxygen].
The data are discussed concerning the protection of cells in vitro by the oxygen reducing agents. The analysis has demonstrated that the protective effect of sulfites can only be related to hypoxia they create. Hypoxia also contributes considerably to the protective effect of thiols (maximum DMF approximately 3). However the protective effect of thiols cannot wholly be attributed to hypoxia. The oxygen--independent component of the protective effect of thiols (maximum DMF approximately 1.5) is conditioned by the metabolic changes increasing the enzymic repair of potential damages.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D000860:Hypoxia / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects* / Q000528:radiation effects; D011836:Radiation Tolerance; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013447:Sulfites / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D013447:Sulfites; D010100:Oxygen
Rol' izmeneniia kontsentratsii kisloroda pri modifikatsii reproduktivnoĭ gibeli kletok in vitro. Soobshchenie 3. Modifikatsiia radiochuvstvitel'nosti soedineniiami, vosstanavlivaiushchimi kislorod.