Relationship of 19-nor-deoxycorticosterone to other mineralocorticoids in low-renin hypertension.
A number of mineralocorticoids have been proposed as etiologic factors in low-renin hypertension. In this study, urinary free 19-nor-deoxycorticosterone (UF 19-nor-DOC) was compared to other mineralocorticoids--aldosterone, deoxycorticosterone (DOC), and 18-OH-DOC, in 11 low-renin hypertensive patients on a controlled diet in a metabolic unit. Results demonstrated that both UF 19-nor-DOC and tetrahydro-DOC (TH-DOC) excretion were elevated (2086 +/- 926, nl = 339-579 ng/day, and 18 +/- 7, nl = 5-15 mcg/day, respectively), and positively correlated (r = 0.95). Neither 18-OH-DOC nor aldosterone secretion rates were elevated, and neither of these hormones correlated with UF 19-nor-DOC, with exception of the supine plasma aldosterone (SPA) (r = 0.86). In conclusion, both UF 19-nor-DOC and TH-DOC were increased and positively correlated in the present series of hypertensives. This association is possibly indicative of a precursor-product relationship between DOC and 19-nor-DOC. 19-Nor-DOC, furthermore, correlated with supine plasma aldosterone (SPA), which could, in part, reflect their shared adrenocorticotropic hormone (ACTH) dependence.
D015070:18-Hydroxydesoxycorticosterone / Q000097:blood / Q000652:urine; D000328:Adult; D000450:Aldosterone / Q000097:blood / Q000652:urine; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000652:urine*; D008297:Male; D008875:Middle Aged; D008901:Mineralocorticoids / Q000652:urine*; D011187:Posture; D012083:Renin / Q000097:blood*
D015070:18-Hydroxydesoxycorticosterone; D008901:Mineralocorticoids; D003900:Desoxycorticosterone; C019026:19-nordeoxycorticosterone; D000450:Aldosterone; D005665:Furosemide; D012083:Renin