Kinetic evaluation of platelet monoamine oxidase following relaxation in chronic anxiety.
The effect of relaxation training, utilizing EMG biofeedback, on platelet monoamine oxidase (MAO) activity was examined in patients with a history of chronic anxiety. Anxiety scores and MAO activity were significantly lowered after 4 weeks of therapy. Kinetic studies, using phenylethylamine as substrate, indicated a significant increase of the Km constant while the Vmax showed no significant or consistent variation. It is thought that this phenomenon represents an adaptive response by the individual to maintain a homeostatic level of the biogenic amines.
D000328:Adult; D001008:Anxiety Disorders / Q000201:enzymology* / Q000628:therapy; D001676:Biofeedback, Psychology; D001792:Blood Platelets / Q000201:enzymology*; D002908:Chronic Disease; D004576:Electromyography; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D009126:Muscle Relaxation; D012064:Relaxation Therapy
D008995:Monoamine Oxidase