Maturation of transplantation antigens in Ambystoma mexicanum.
Both juvenile (14-16 week) and adult (18 month) Ambystoma mexicanum reject skin allografts from adult Ambystoma more speedily than they reject such grafts from juvenile axolotls. Donor-specific histocompatibility antigen, prepared from splenocytes, is more effective in inhibiting adult host splenocyte migration when the antigen is prepared from spleen cells from adult, rather than from juvenile Ambystoma. The thymus is fully developed in juvenile Ambystoma, suggesting that the delayed kinetics of rejection of juvenile allografts reflects immaturity in the expression of histocompatibility antigens to donor skin cells.
D000367:Age Factors; D000557:Ambystoma / Q000276:immunology*; D000558:Ambystoma mexicanum / Q000276:immunology*; D000818:Animals; D002464:Cell Migration Inhibition; D005260:Female; D006084:Graft Rejection; D006649:Histocompatibility Antigens; D008297:Male; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000254:growth & development / Q000276:immunology; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens