title: [Genetic analysis of the structure of the predisposition to diabetes mellitus. I. Genetic epidemiological approaches to an analysis of age-dependent multifactorial diseases].
abstract: The statistical methods for genetic analysis of multifactorial diseases (MFD) with variable age-at-onset are developed. It is emphasized that the index numbers used in the genetical-epidemiological studies, such as frequency of MFD in the population (qg--incidence) and that among family members (PR), should be independent on the demographic structure of both the population and the families. The mathematical grounds for the estimating methods as well as biological meaning for such index numbers are given. The approach suggested will be used later in analysis of the structure of predisposition to diabetes mellitus.
mesh_terms: D000367:Age Factors; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000235:genetics*; D004198:Disease Susceptibility; D004812:Epidemiologic Methods; D005821:Genetic Techniques; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D010641:Phenotype; D011336:Probability; D013223:Statistics as Topic
vernacular_title: Geneticheskiĭ analiz struktury predraspolozheniia k sakharnomu diabetu. Soobshchenie I. Genetiko-épidemiologicheskie podkhody k analizu vozrastzavisimyKh mul'tifaktorial'nykh zabolevaniĭ.