title: The sequence of the nucleotides at the alpha-sarcin cleavage site in rat 28 S ribosomal ribonucleic acid.
abstract: The sequence of the 521 nucleotides at the 3' end of a rat 28 S rRNA gene was determined. The region encompasses the site of cleavage of 28 S rRNA by the cytotoxin alpha-sarcin. The toxin hydrolyzes a phosphodiester bond on the 3' side of a guanine residue 393 nucleotides from the 3' end. The alpha-sarcin domain is composed of a purine-rich sequence of 14 highly conserved nucleotides.
mesh_terms: D000818:Animals; D001230:Aspergillus; D001483:Base Sequence; D004722:Endoribonucleases; D005656:Fungal Proteins / Q000494:pharmacology*; D008099:Liver; D008970:Molecular Weight; D012335:RNA, Ribosomal; D051381:Rats; D012270:Ribosomes; D012441:Saccharomyces cerevisiae; D013045:Species Specificity; D014981:Xenopus
chemical_list: D005656:Fungal Proteins; D012335:RNA, Ribosomal; C014801:alpha-sarcin; D004722:Endoribonucleases