Restoration by insulin of the responsiveness of stimulated adipocytes to adenosine.
The stimulation of adipocyte-cyclase by isoproterenol decreases its sensitivity to adenosine, with, as a consequence, a decrease in its antilipolytic effect. The presence of insulin under conditions where its action on the phosphodiesterase activity is impaired, restores the responsiveness of adenylate-cyclase and of lipolysis to adenosine.
D000241:Adenosine / Q000494:pharmacology*; D000262:Adenylyl Cyclases / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects* / Q000201:enzymology; D000818:Animals; D007328:Insulin / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D010660:Phenylisopropyladenosine; D000262:Adenylyl Cyclases; D000241:Adenosine; D007545:Isoproterenol