A comparative study of atenolol and penbutolol in hypertensive patients.
In a randomized controlled, double-blind clinical trial with 45 patients with moderate hypertension atenolol 100 mg and penbutolol 40 mg were equally effective in lowering the blood pressure. During the 6 weeks of treatment there was no change in body weight and serious side-effects were not observed, but bradycardia occurred more frequently with atenolol than with penbutolol. Withdrawal of medication during the final week of the study did not cause any adverse reaction.
D000328:Adult; D001262:Atenolol / Q000627:therapeutic use*; D001794:Blood Pressure; D002986:Clinical Trials as Topic; D003971:Diastole; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010394:Penbutolol / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use*; D011674:Pulse; D013599:Systole
D011412:Propanolamines; D001262:Atenolol; D010394:Penbutolol