[Relation between the binding of 3H-imipramine and the uptake of catecholamines in synaptosomal preparations of the rat brain after chronic treatment with imipramine].
After 3 weeks treatment with imipramine (7.5 mg/kg/ip), 5-hydroxytryptamine uptake in rat brain homogenates was not affected whereas noradrenaline uptake was lowered. This result could be explain by metabolism of imipramine producing desipramine.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins; D004298:Dopamine / Q000378:metabolism*; D007099:Imipramine / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D014018:Tissue Distribution
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D012701:Serotonin; D007099:Imipramine; D004298:Dopamine; D009638:Norepinephrine
Relation entre la fixation de l'3H-imipramine et le recaptage des catécholamines et de la sérotonine dans des préparations synaptosomales de cerveau de rat après un traitement chronique par l'imipramine.