Ticlopidine hydrochloride: relationship between dose, kinetics, plasma concentration and effect on platelet function.
This is a review of the available data about the pharmacodynamic profile of ticlopidine in man in relation to its pharmacokinetic and metabolic characteristics. There is a rapid dose-dependent onset of effect on platelet function and a time-dependent effect on bleeding. The ticlopidine effect appears to be due to the direct action on circulating platelets. The contributions of a metabolite, a 2-keto derivative, is also discussed.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005343:Fibrinolytic Agents; D006801:Humans; D007700:Kinetics; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013876:Thiophenes / Q000097:blood / Q000494:pharmacology*; D013988:Ticlopidine; D013997:Time Factors
D005343:Fibrinolytic Agents; D013876:Thiophenes; D000244:Adenosine Diphosphate; D003094:Collagen; D013988:Ticlopidine