title: Immunoperoxidase localization of catechol-o-methyl transferase (COMT) in human breast cancer.
abstract: Immunoperoxidase reaction of appropriately fixed tissue with an antiserum to catechol-o-methyl transferase (COMT), as the primary step in the peroxidase-immunoglobulin bridge technique, has been utilized for the localization of COMT in biopsy specimens of human breast neoplasm and its metastases. Our immunocytochemical identification of a strong activity of COMT in all cases studied might have a diagnostic implication in breast cancer.
mesh_terms: D001940:Breast / Q000201:enzymology; D001943:Breast Neoplasms / Q000201:enzymology* / Q000556:secondary; D002394:Catechol O-Methyltransferase / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques
chemical_list: D002394:Catechol O-Methyltransferase