[Glial fibrillary acidic protein and central nervous system tumors. Immunohistochemical study of a series of 207 cases. 2: Medulloblastomas. Hemangioblastomas. Other tumors. Discussion].
The presence of glial fibrillary acidic protein (GFA) was tested in biopsy or autopsy specimens of 207 human central nervous system tumors. Samples were fixed, paraffin-embedded and GFA was detected using the peroxidase-antiperoxidase technique. The second part of this study dealt mainly with medulloblastomas and hemangioblastomas. Of the 17 cerebellar medulloblastomas, 15 contained less than 5% GFA positive cells. These were classified according to the Mannoji et al., 1981, criteria. Ten medulloblastomas contained type 1, 2 and 3 cells; 1 was composed of only type 1 cells, and 4 were composed of only type 3 cells. Of the 8 cerebellar or medullary hemangioblastomas, 3 contained only a few GFA positive cells which were, in two cases stroma cells and in another, astrocytes. GFA positive cells were found in 7 oligoastrocytomas, 3 gangliogliomas and 1 hamartoma of the hypothalamus. Similarly, a GFA positive astrocytic differentiation was found in a pineocytoma. In a case of tuberous sclerosis no GFA was found in the giant cells of cortical tubers. Nor was GFA observed in one intracerebral tumor of tuberous sclerosis. GFA was not found in 5 meningiomas, 4 oligodendrogliomas, 4 pituitary adenomas, 3 neurinomas of the VIII cranial nerve, 1 primary cerebellar malignant lymphoma, 1 familial lymphohistiocytosis with cerebellar involvement and 4 brain metastases. The authors also include diagnostic, histogenetic and nosological comments -about neuroglial tumors. The findings in the two parts of this study fail to establish a correlation between GFA positivity and histological grade of astrocytomas and glioblastomas.
D000328:Adult; D001932:Brain Neoplasms / Q000032:analysis*; D002528:Cerebellar Neoplasms / Q000032:analysis; D002648:Child; D005260:Female; D005904:Glial Fibrillary Acidic Protein; D006394:Hemangiosarcoma / Q000032:analysis* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000032:analysis*; D008297:Male; D008527:Medulloblastoma / Q000032:analysis* / Q000473:pathology
D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins
Protéine gliofibrillaire acide (GFA) et tumeurs nerveuses centrales. Etude immunohistochimique d'une série de 207 cas. IIe Partie: Médulloblastomes. Hémangioblastomes. Autres tumeurs. Discussion.