Fasting and postprandial plasma glucagon and glucagon-like immunoreactivity are normal in obese Pima Indians.
Glucose, insulin (IRI), glucagon (IRG) and GLI were measured in plasma samples obtained from 32 subjects representing a wide range of body weight (body mass index = 21-49 kg/m2) after an overnight fast and for 6 hr following ingestion of a standard test meal. The 6 hr integrated postprandial response of each hormone was estimated for each subject from the area of the response curve above basal concentration. Both fasting (r = 0.72, p less than 0.0001) and postprandial (r = 0.45, p less than 0.01) IRI were significantly correlated with degree of obesity, as expected. However, the fasting and postprandial plasma glucagon and glucagon-like immunoreactivity levels were not related to obesity of the subject and were not different for the obese (BMI greater than 35, n = 16) and nonobese (BMI less than 30, n = 12) groups. Thus, there is no evidence for an abnormality in the response of these peptide hormones to a mixed meal in this obese population.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005215:Fasting; D005502:Food; D005934:Glucagon / Q000097:blood*; D004763:Glucagon-Like Peptides; D006801:Humans; D007198:Indians, North American; D007328:Insulin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D010455:Peptides / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D010455:Peptides; D004763:Glucagon-Like Peptides; C015236:glucagon-like-immunoreactivity; D005934:Glucagon