Alcohol-induced euphoria enhanced by disulfiram and calcium carbimide.
In a double-blind study, subjects were treated with either disulfiram or calcium carbimide, inhibitors of acetaldehyde elimination, prior to consumption of low doses of alcohol. Self-rating scales, individual interviews, and observations by independent judges revealed that experimental subjects manifested enhanced changes in mood and euphoria compared to placebo control subjects.
D000079:Acetaldehyde / Q000097:blood; D000328:Adult; D003484:Cyanamide / Q000494:pharmacology*; D003486:Cyanides / Q000494:pharmacology*; D004221:Disulfiram / Q000494:pharmacology*; D004311:Double-Blind Method; D004357:Drug Synergism; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005059:Euphoria / Q000187:drug effects*; D006801:Humans; D008297:Male
D003486:Cyanides; D000431:Ethanol; D003484:Cyanamide; D000079:Acetaldehyde; D004221:Disulfiram