title: Simple screening techniques for the detection of hypercoagulation. A study of 53 children suffering from familial hypercholesterolemia type IIa.
abstract: A number of new screening techniques to detect the tendency to hypercoagulability in children with familial hypercholesterolemia is presented. The use of Thrombokinetics (TKG) and the introduction of a quotient as a new parameter are discussed. The new techniques are compared with the conventional methods. The link of an increased quotient with the activated stage of factor VII has been shown in a pilot study. For the definition of normal values there is a need of a normal pool which has been critically prepared.
mesh_terms: D000293:Adolescent; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000209:etiology; D001780:Blood Coagulation Tests / Q000295:instrumentation / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D003626:Data Display; D005167:Factor VII / Q000032:analysis; D015942:Factor VIIa; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications*; D008433:Mathematics; D008832:Microchemistry; D010314:Partial Thromboplastin Time; D010714:Phosphatidylethanolamines; D011933:Reagent Kits, Diagnostic
chemical_list: D010714:Phosphatidylethanolamines; D011933:Reagent Kits, Diagnostic; C045602:cephaloplastin reagent; D005167:Factor VII; D015942:Factor VIIa