Poly(8-bromo-2'-deoxyadenylic acid): the syn/anti relationship.
The synthesis of a high-molecular-weight, putatively all-syn DNA analogue, poly(8-bromo-2'-deoxyadenylic acid), is described. The syn----anti transition was shown to be both salt and temperature dependent. Conditions were found which favored 'normal' Watson-Crick pairing and duplex formation with poly(dT).
D002942:Circular Dichroism; D004247:DNA / Q000138:chemical synthesis; D004277:DNA, Single-Stranded; D003839:Deoxyadenosines / Q000031:analogs & derivatives*; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D011061:Poly A; D011067:Poly dA-dT; D011089:Polydeoxyribonucleotides; D013237:Stereoisomerism
D004277:DNA, Single-Stranded; D003839:Deoxyadenosines; D011089:Polydeoxyribonucleotides; C042464:8-bromo-2'-deoxyadenosine; D011061:Poly A; D011067:Poly dA-dT; D004247:DNA; C042465:poly(8-bromo-2'-deoxyadenylic acid)