[Effect of thiopental anesthesia on plasma renin, adrenaline and noradrenaline in neurosurgical operations with induced hypotension].
Excessive postoperative blood pressure reactions following surgery of cerebral aneurysms using sodium nitroprusside--induced hypotension can be avoided, if barbiturate-fentanyl-anaesthesia is employed instead of neuroleptanalgesia. Plasma renin activity (PRA), plasma concentration of adrenaline and noradrenaline were determined in 13 patients, undergoing surgery of cerebral aneurysms with induced hypotension (group I) and in 15 patients, who were operated on for brain tumors without hypotension (group II). The PRA was not increased in group II. The blood pressure was normal. In group I the PRA was significantly higher during and after the operation. In both groups adrenaline was not increased significantly. The noradrenaline concentration showed a significant increase in both groups, indicating a peripheral sympathetic stimulation. It is supposed that thiopentone inhibits the depletion of adrenaline and reduces the effect of increased PRA.
D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D001932:Brain Neoplasms / Q000601:surgery; D004837:Epinephrine / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007023:Hypotension, Controlled; D019635:Neurosurgical Procedures; D009638:Norepinephrine / Q000097:blood*; D012083:Renin / Q000097:blood*; D013874:Thiopental
D012083:Renin; D013874:Thiopental; D009638:Norepinephrine; D004837:Epinephrine
Der Einfluss von Thiopental-Narkosen auf Plasma-Renin, Adrenalin und Noradrenalin bei neurochirurgischen Operationen in Hypotension.