[Effect of bacterial endotoxin on gastric emptying and on passive absorption of salicylate in the small intestine].
The salicylate content in blood plasma after its administration into the stomach and small intestine during experimental endotoxemia in mice has been measured. In early stages of intoxication gastric evacuation was fairly slow. Histamine increased, while its antagonist pyrilamine significantly reduced the observed disorder. In the last stages of intoxication, passive absorption in the small intestine increased. Administration of histamine, serotonin and ciproheptadine did not produce any essential effect on the salicylate transport across the intestinal wall.
D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D005746:Gastric Emptying; D006632:Histamine / Q000502:physiology; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000503:physiopathology; D008297:Male; D051379:Mice; D012701:Serotonin / Q000502:physiology; D012764:Shigella sonnei; D012980:Sodium Salicylate / Q000097:blood*
D004731:Endotoxins; D012701:Serotonin; D006632:Histamine; D012980:Sodium Salicylate
O vliianii bakterial'nogo éndotoksina na zheludochnuiu évakuatsiiu i passivnoe vsasyvanie salitsilata v tonkoĭ kishke.