[Quantitative relationships between various representatives of gastrointestinal microflora of experimental animals (rats) in normal conditions and after immunosuppression with imuran].
The influence of imuran (an analog of nitrogen ioprin) on the quantitative relationship between lactobacilli, bifidobacteria, bacteroids and aerobic autoflora in different sections of the gastrointestinal tract of white rats was studied under experimental conditions. On days 7-14-30 after the introduction of imuran into the gastrointestinal tract dysbacteriosis developed; it was characterized by a decrease in the number of lactobacilli and asporogenic anaerobic microflora and an increase in the number of aerobic microorganisms. By days 60-90 the content of aerobic microbes in all sections of the gastrointestinal tract was still elevated, while the rapid restoration of the number of bacteroids took place. Therefore, immunosuppression therapy with imuran may give rise to autoinfectious complications caused by different representatives of infective microflora.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology*; D001439:Bacteroides / Q000187:drug effects*; D002175:Candida / Q000187:drug effects; D004064:Digestive System / Q000382:microbiology*; D004755:Enterobacteriaceae / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D007778:Lactobacillus / Q000187:drug effects*; D008828:Microbiological Techniques; D011511:Proteus / Q000187:drug effects; D051381:Rats; D013210:Staphylococcus / Q000187:drug effects
D001379:Azathioprine
Kolichestvennye vzaimootnosheniia otdel'nykh predstaviteleĭ mikroflory zheludochno-kishechnogo trakta éksperimental'nykh zhivotnykh (krys) v norme i pri immunosupressii imuranom.