[The role of prostacyclin(PGI2) in the regulation of blood pressure and aldosterone response to angiotensin II].
The pressor response to angiotensin II (A II) has been shown to be enhanced, and aldosterone production to be attenuated following administration of indomethacin (Ind), a cyclooxygenase inhibitor, pretreatment. Since PGI2 has been proposed to be a potent vasodepressor prostaglandins, with steroidogenic action, the present study was undertaken to evaluate the regulatory role of PGI2 in the blood pressure and aldosterone responses to A II. Ind was administered to suppress the production of endogenous prostaglandins (30 mg/kg. im. Ind-group) and PGI2 was given after Ind pretreatment (2 ng/kg/min. iv. Ind + PGI2 group) to conscious male rabbits (2.5 approximately 3.5 kg). Baseline blood pressure readings were similar in three groups (control, Ind-, and Ind + PGI2-group). The increment of blood pressure by A II infusion were significantly enhanced in the Ind-group (12.6 +/- 1.3 mmHg) compared with the control-group (8.6 +/- 1.5 mmHg). This enhancement was diminished by PGI2 infusion (7.0 +/- 2.3 mmHg). PGI2 infusion alone does not influence blood pressure in the dose of 0.5 approximately 4.0 ng/kg/min. Aldosterone response to A II was significantly attenuated in the Ind-group (1.5 +/- 1.2 ng/dl) compared with the control-group (7.5 +/- 3.1 ng/dl), but was restored in the Ind + PGI2-group (4.5 +/- 1.3 ng/dl). It is suggested that circulating PGI2 may play a role in the regulation of blood pressure by modulating the pressor response and the aldosterone response to A II.
D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D011464:Epoprostenol / Q000494:pharmacology*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D011460:Prostaglandins F / Q000097:blood; D011817:Rabbits; D012083:Renin / Q000097:blood
D011453:Prostaglandins; D011460:Prostaglandins F; D000804:Angiotensin II; D000450:Aldosterone; D011464:Epoprostenol; D012083:Renin; C100006:prostaglandin F1