[Electron microscope analysis of the transplacental effect of azathioprine on the pancreas of albino mouse embryos].
An electron microscopic investigation has been performed to study the transplantation effect of azathioprine (imuran) on the pancreas of the white mouse embryos. Azathioprine is administered to female mice at various time of pregnancy. The pancreas of 19-20-day-old embryos is studied. Azathioprine produces an unfavourable effect on the embryonal pancreacytes; it is manifested as some disorders in structure of organelles, appearance of the intracellular degeneration foci, disturbed maturation of the zymogen granules, premature secretion of zymogen into the acinar lumen during the prenatal period. In the insulocytes similar changes are observed in their organelles, as well as appearance of unusual in size alpha- and beta-granules. As a whole, the epithelium of the endocrine part of the gland is evidently more resistive to the preparation.
D000818:Animals; D001379:Azathioprine / Q000009:adverse effects*; D004622:Embryo, Mammalian; D005260:Female; D007515:Islets of Langerhans / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D010179:Pancreas / Q000187:drug effects / Q000648:ultrastructure*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D001379:Azathioprine
Ul'tramikroskopicheskiĭ analiz transplatsentarnogo deĭstviia azatioprina na podzheludochnuiu zhelezu émbrionov beloĭ myshi.