Influence of cefaclor on immune response parameters.
The effect of cefaclor (CCl) and other orally applied antibiotics were examined on different parameters of the immune response. It could be shown that CCl enhances specific IgM response in a dose dependent profile. This is dependent on the application time relative to immunization because it reduces the reaction if given thereafter. IgG response is inhibited in low but not in higher doses. Cellular immune reaction in CCl treated animals evaluated with the footpad swelling test shows also a dose dependent profile but it is always enhanced compared with controls. The cortisone or cyclophosphamide induced immunosuppression is largely abrogated. Prostaglandin E2 (PGE2) production by macrophages and PGE2-sensitivity of lymphocytes are rather reduced if cell donors were treated with CCl. Interleukin 1 production is clearly stimulated. The enhanced survival rate of CCl treated animals observed in experimental infections with the primary resistant Candida species is explained by the concomitant inhibition of PGE2-production as an inhibitor of immune reactions and reduction of PGE2-sensitivity together with a stimulation of cellular immunity.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002433:Cefaclor / Q000494:pharmacology*; D002506:Cephalexin / Q000031:analogs & derivatives*; D003348:Cortisone / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D015232:Dinoprostone; D007111:Immunity, Cellular / Q000187:drug effects*; D007375:Interleukin-1 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011458:Prostaglandins E / Q000096:biosynthesis / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology; D013997:Time Factors
D007375:Interleukin-1; D011458:Prostaglandins E; D002433:Cefaclor; D003520:Cyclophosphamide; D015232:Dinoprostone; D002506:Cephalexin; D003348:Cortisone