Platelet products and vascular PGI2 production.
The effects of products synthesized and/or secreted by activated platelets on production of PGI2 by human, rat and rabbit vascular rings were investigated. Of the platelet dense body constituents, 5HT stimulated PGI2 production by vascular tissue of all three species whereas ADP was active only on rat tissue. Of the lipids produced during platelet activation, PAF stimulated PGI2 production by vascular tissue of all three species, Lysophosphatidate was less active than PAF on rabbit and human tissue and inactive in rat tissue, and the TxA2-mimetic, U46619, was inactive on vascular tissue of all three species. It is concluded that there are species variations in the effects of agonists on vascular PGI2 production and that platelet-derived products other than platelet-derived growth factor and beta-thromboglobulin could modulate PGI2 production to regulate platelet activation in vivo.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism; D001013:Aorta, Thoracic / Q000378:metabolism; D001792:Blood Platelets / Q000502:physiology*; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D008246:Lysophospholipids; D008297:Male; D010712:Phosphatidic Acids / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013045:Species Specificity; D014469:Umbilical Arteries / Q000378:metabolism
D008246:Lysophospholipids; D010712:Phosphatidic Acids; D010972:Platelet Activating Factor; D011453:Prostaglandins; D012701:Serotonin; D000244:Adenosine Diphosphate; D011464:Epoprostenol