title: 24-36-Chromosome clones in human malignancies. Cytogenetic interrelationships, clinical significance and patient age.
abstract: The literature has been reviewed for cases of malignant disease showing cellular clones with 24-36 chromosomes. Such cases are characterized by aggressive disease. Together the clones with 24-36 chromosomes compose a remarkably consistent non-random cytogenetic pattern, which demonstrates that different chromosomes are of different value for cellular survival and clonal propagation. Considering that the tissues of origin are very different (various solid tumours and different leukaemias), the close mutual cytogenetic relationship between the clones indicates that the cytogenetic pattern is tissue non-specific. Karyotypic non-specificity of cells with very different phenotypes is an apparent contradiction, which raises important questions concerning the relation between karyotype and phenotype.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002999:Clone Cells; D005260:Female; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D011003:Ploidies