title: Failure of captopril to reverse the renal crisis of scleroderma.
abstract: Captopril, an oral inhibitor of angiotensin converting enzyme, has recently been described as causing a dramatic reversal of the renal crisis in scleroderma in 2 patients(1). We report here 2 patients with scleroderma, hypertension, and rapidly deteriorating renal function who were given captopril. Despite good blood pressure control, captopril had no effect on renal function, both patients requiring long-term haemodialysis.
mesh_terms: D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007674:Kidney Diseases / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy*
chemical_list: D011392:Proline; D002216:Captopril