Chromosome studies in patients with T-CLL chronic lymphocytic leukemia and expansions of granular lymphocytes.
Chromosome analyses were carried out in eight patients with lymphoproliferative disorders of mature T and NK cells. Three cases were characterized by an abnormal expansion of granular lymphocytes (GL), one by a lymphoma of GL with leukemic spread, and four by an OKT4-T-CLL. In four patients cytogenetic studies were performed on bone marrow cells; in seven patients peripheral blood lymphocytes were examined by either direct preparations or PHA-stimulated cultures. Six patients displayed a normal karyotype. Two cases belonging to the OKT4-T-CLL group had a chromosome number ranging from 44 to 47, with multiple numerical and structural clonal anomalies. Clonal anomalies could be a feature of patients with the more aggressive clinical course.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002869:Chromosome Aberrations; D005260:Female; D006098:Granulocytes / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes
D000911:Antibodies, Monoclonal